OTX015 displayed higher antiproliferative effects compared to its analog JQ1, with GI50 values of approximately 0.2 &#181;M. In addition, C-MYC and CDKN1A mRNA levels increased transiently after 4 h-exposure to OTX015, while BRD2, SESN3, HEXIM-1, HIST2H2BE, and HIST1H2BK were rapidly upregulated and sustained after 24 h. Studies in three additional GBM cell lines supported the antiproliferative effects of OTX015.
C1621958
Glioblastoma Multiforme