We demonstrate that the mechanical hyperalgesia induced by intradermal injection of BK can be blocked by the kappa-opioid agonist trans-3,4-dichloro-N-methyl-N[2-(-pyrrolidinyl)cyclo-hexyl] benzeneacetamide (U50,488H) and by the delta-opioid agonist (D-Pen2,5)-enkephalin (DPDPE), as well as the mu-opioid agonist Tyr-D-Ala-Gly-NMe-Phe-Gly-ol(DAMGO).
C2936719
Mechanical Allodynia