Although the granulocyte nadirs were significantly lower at each 5-FU dose level with the concurrent GM-CSF schedule (eg, 490 mg/m2/d: median, 879/microL v3,286/microL; two-tailed P [P2] &lt; .001), dose-limiting granulocytopenia complicated &lt; or = 16% of cycles with 5-FU &lt; or = 560 mg/m2/d (99 cycles); &gt; or = grade 3 mucositis occurred in &lt; or = 20% of cycles.
C0333355
Inflammatory disease of mucous membrane