By contrast, early-onset vincristine-induced peripheral neuropathy was characterised by upregulation of genes involved in cell cycle and proliferation, including AURKA (3&#183;31 times; p=1&#183;04&#215;10(-2)) and MKI67 (3&#183;66 times; p=1&#183;82&#215;10(-3)), and the presence of SNPs in genes involved in these processes-eg, GLI1 (rs2228224 [0&#183;13, 0&#183;02-0&#183;97, p=1&#183;18&#215;10(-2)] and rs2242578 [0&#183;14, 0&#183;02-1&#183;12, p=3&#183;00&#215;10(-2)]).
C4721453
Peripheral Nervous System Diseases