$(2 + 1)(2^2 + 1^2)(2^4 + 1^4) = 3 \cdot 5 \cdot 17 = \boxed{255}$
The answer is: 255
Below is a math problem. Provide a detailed, step-by-step solution.

### Problem:
Evaluate $(2 + 1)(2^2 + 1^2)(2^4 + 1^4)$.

### Answer:
