<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>baddox</author><text>Even if you assume that ending age-related disease is the best cause, you also have to estimate the likelihood of them actually being successful and weight your recommendations by that likelihood.</text><parent_chain><item><author>reasonattlm</author><text>Clearly the SENS Research Foundation, as a 501c3 charity that gives you the 80&amp;#x2F;20 win for a good expectation value for your dollars to do the most good in speeding up progress towards ending age-related disease. If you want to do better than the SRF at assigning dollars to speeding up progress towards ending age-related disease, you&amp;#x27;re going to have to spend some years reading research and making connections. (I wish more people would, actually, no such thing as too much help here).&lt;p&gt;Age-related disease kills ~100,000 people every day, and causes horrible day to day suffering for hundreds of millions of others. Nothing else comes even close as a single presently addressable cause of terrible things in the world, and lack of money is the greatest obstacle to progress towards meaningful treatments that address the root causes of aging and thus all age-related disease.</text></item></parent_chain></comment><story><title>The Greatest Good: What is the best charitable cause in the world?</title><url>http://www.theatlantic.com/business/archive/2015/06/what-is-the-greatest-good/395768?single_page=true</url></story>
<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>bhouston</author><text>SENS Research Foundation is made for relatively wealthy people who already have money and health who want to live longer.  Do they have any successes or measures of efficiency?  It seems like science fiction pie in the sky research by a small group of true believers.</text><parent_chain><item><author>reasonattlm</author><text>Clearly the SENS Research Foundation, as a 501c3 charity that gives you the 80&amp;#x2F;20 win for a good expectation value for your dollars to do the most good in speeding up progress towards ending age-related disease. If you want to do better than the SRF at assigning dollars to speeding up progress towards ending age-related disease, you&amp;#x27;re going to have to spend some years reading research and making connections. (I wish more people would, actually, no such thing as too much help here).&lt;p&gt;Age-related disease kills ~100,000 people every day, and causes horrible day to day suffering for hundreds of millions of others. Nothing else comes even close as a single presently addressable cause of terrible things in the world, and lack of money is the greatest obstacle to progress towards meaningful treatments that address the root causes of aging and thus all age-related disease.</text></item></parent_chain></comment><story><title>The Greatest Good: What is the best charitable cause in the world?</title><url>http://www.theatlantic.com/business/archive/2015/06/what-is-the-greatest-good/395768?single_page=true</url></story>