<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>inciampati</author><text>No, it&amp;#x27;s impossible for them to categorically show that it wasn&amp;#x27;t. However, they could make an extremely strong case if they completely documented all ongoing research activities in the lab before the beginning of the pandemic. This would involve total disclosure of the activity of every researcher, open access to all materials and the sequencing of all viral samples and cultures.&lt;p&gt;It is not feasible to do this probably. The WIV even claims to have completely consumed all biosamples related to RaTG13, which is the most-closely-related known virus to SARS-CoV-2. Supporting such an investigation is completely counter to their interests (speaking both of the institute and the CCP).&lt;p&gt;The overwhelming evidence is that SARS-CoV-2 emerged completely adapted to humans. This has been confirmed by the amazing lack of initial adaptation to the new human host. We only saw major changes in the spike resulting in a change in phenotype later in 2020. The proximal origins of the spike protein suggest a primate or human host. For this to happen, a natural origin in another species is astronomically improbable. It&amp;#x27;s the strongest evidence that we&amp;#x27;ll ever have as to the origins of the virus, and to this biologist it is completely indicative of what happened. We will only know the full truth if people speak out.</text><parent_chain><item><author>lostinquebec</author><text>I don&amp;#x27;t understand how this works, so forgive my ignorance.&lt;p&gt;Wouldn&amp;#x27;t the Wuhan lab be able to disprove this really easily? How often do they sequence viruses? Couldn&amp;#x27;t they show categorically that COVID-19 is not a descendant of a virus they were working with&amp;#x2F;on?</text></item><item><author>NineStarPoint</author><text>It’s worth noting that in both the Sverdlov case and in this one, world scientists are only being given access to the situation in an extremely controlled fashion. A primary reason we can’t say more on what happened in this case is the CCP’s tight control over access that could help clarify the situation.&lt;p&gt;Which will always look suspicious, whether it was actually a completely natural virus or not.</text></item><item><author>loveistheanswer</author><text>&amp;gt;I can say the vast majority of us are not qualified to answer the question either way though.&lt;p&gt;It&amp;#x27;s also worth noting that even the leading experts can get these things wrong, as was the case with the Sverdlovsk lab leak.&lt;p&gt;Soviet authorities covered it up by blaming local meat markets, and leading US experts concurred with them, only to reverse their conclusion 6 years later.&lt;p&gt;&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;en.m.wikipedia.org&amp;#x2F;wiki&amp;#x2F;Sverdlovsk_anthrax_leak#Accident&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;en.m.wikipedia.org&amp;#x2F;wiki&amp;#x2F;Sverdlovsk_anthrax_leak#Acci...&lt;/a&gt;</text></item><item><author>eightysixfour</author><text>I feel like people are doing a poor job distinguishing between &amp;quot;engineered&amp;quot; and &amp;quot;leaked.&amp;quot;&lt;p&gt;There is, from my understanding, reasonable evidence to conclude the virus was not engineered from the perspective of &amp;quot;we took genes from one virus and moved them to this virus,&amp;quot; but there&amp;#x27;s no evidence disproving the idea that it was the result of gain of function research.&lt;p&gt;My personal feeling is that these statements are true:&lt;p&gt;* The virus is unlikely to have been engineered (in the way I described above) and leaked.&lt;p&gt;* There is circumstantial evidence the virus was the result of gain of function research and it leaked.&lt;p&gt;* There is circumstantial evidence the virus was a natural research sample and it leaked.&lt;p&gt;* There is circumstantial evidence the virus was introduced by an animal&amp;#x2F;person who traveled to the wet market.&lt;p&gt;Some of these are more likely than others, and an individual&amp;#x27;s own calibration for what is likely or unlikely will probably come into play more than evidence in the short term and possibly long term as well. I can say the vast majority of us are not qualified to answer the question either way though.</text></item><item><author>loveistheanswer</author><text>Judging by the comments in this thread, it seems a lot of people are still unaware that:&lt;p&gt;1. Gain of function research primarily uses samples collected from nature, and seeks to stimulate their evolution in as natural a way as possible to learn how viruses evolve in nature. If such viruses were to escape the lab, they would appear &amp;quot;natural&amp;quot;&lt;p&gt;2. It&amp;#x27;s not xenophobic for people from the US to suggest the possibility of a lab leak, because the US was itself funding gain of function research on novel coronaviruses in the Wuhan BSL4 lab&lt;p&gt;3. Lab leaks happen more often than most people realize[1]&lt;p&gt;[1]&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.vox.com&amp;#x2F;future-perfect&amp;#x2F;2019&amp;#x2F;3&amp;#x2F;20&amp;#x2F;18260669&amp;#x2F;deadly-pathogens-escape-lab-smallpox-bird-flu&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.vox.com&amp;#x2F;future-perfect&amp;#x2F;2019&amp;#x2F;3&amp;#x2F;20&amp;#x2F;18260669&amp;#x2F;deadly...&lt;/a&gt;</text></item></parent_chain></comment><story><title>Scientists who say the lab-leak hypothesis for SARS-CoV-2 shouldn&apos;t be ruled out</title><url>https://www.technologyreview.com/2021/03/18/1021030/coronavirus-leak-wuhan-lab-scientists-conspiracy/</url></story>
<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>seoaeu</author><text>How would you know they provided a complete list of viruses they were working on? Couldn&amp;#x27;t they just leave off anything incriminating?</text><parent_chain><item><author>lostinquebec</author><text>I don&amp;#x27;t understand how this works, so forgive my ignorance.&lt;p&gt;Wouldn&amp;#x27;t the Wuhan lab be able to disprove this really easily? How often do they sequence viruses? Couldn&amp;#x27;t they show categorically that COVID-19 is not a descendant of a virus they were working with&amp;#x2F;on?</text></item><item><author>NineStarPoint</author><text>It’s worth noting that in both the Sverdlov case and in this one, world scientists are only being given access to the situation in an extremely controlled fashion. A primary reason we can’t say more on what happened in this case is the CCP’s tight control over access that could help clarify the situation.&lt;p&gt;Which will always look suspicious, whether it was actually a completely natural virus or not.</text></item><item><author>loveistheanswer</author><text>&amp;gt;I can say the vast majority of us are not qualified to answer the question either way though.&lt;p&gt;It&amp;#x27;s also worth noting that even the leading experts can get these things wrong, as was the case with the Sverdlovsk lab leak.&lt;p&gt;Soviet authorities covered it up by blaming local meat markets, and leading US experts concurred with them, only to reverse their conclusion 6 years later.&lt;p&gt;&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;en.m.wikipedia.org&amp;#x2F;wiki&amp;#x2F;Sverdlovsk_anthrax_leak#Accident&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;en.m.wikipedia.org&amp;#x2F;wiki&amp;#x2F;Sverdlovsk_anthrax_leak#Acci...&lt;/a&gt;</text></item><item><author>eightysixfour</author><text>I feel like people are doing a poor job distinguishing between &amp;quot;engineered&amp;quot; and &amp;quot;leaked.&amp;quot;&lt;p&gt;There is, from my understanding, reasonable evidence to conclude the virus was not engineered from the perspective of &amp;quot;we took genes from one virus and moved them to this virus,&amp;quot; but there&amp;#x27;s no evidence disproving the idea that it was the result of gain of function research.&lt;p&gt;My personal feeling is that these statements are true:&lt;p&gt;* The virus is unlikely to have been engineered (in the way I described above) and leaked.&lt;p&gt;* There is circumstantial evidence the virus was the result of gain of function research and it leaked.&lt;p&gt;* There is circumstantial evidence the virus was a natural research sample and it leaked.&lt;p&gt;* There is circumstantial evidence the virus was introduced by an animal&amp;#x2F;person who traveled to the wet market.&lt;p&gt;Some of these are more likely than others, and an individual&amp;#x27;s own calibration for what is likely or unlikely will probably come into play more than evidence in the short term and possibly long term as well. I can say the vast majority of us are not qualified to answer the question either way though.</text></item><item><author>loveistheanswer</author><text>Judging by the comments in this thread, it seems a lot of people are still unaware that:&lt;p&gt;1. Gain of function research primarily uses samples collected from nature, and seeks to stimulate their evolution in as natural a way as possible to learn how viruses evolve in nature. If such viruses were to escape the lab, they would appear &amp;quot;natural&amp;quot;&lt;p&gt;2. It&amp;#x27;s not xenophobic for people from the US to suggest the possibility of a lab leak, because the US was itself funding gain of function research on novel coronaviruses in the Wuhan BSL4 lab&lt;p&gt;3. Lab leaks happen more often than most people realize[1]&lt;p&gt;[1]&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.vox.com&amp;#x2F;future-perfect&amp;#x2F;2019&amp;#x2F;3&amp;#x2F;20&amp;#x2F;18260669&amp;#x2F;deadly-pathogens-escape-lab-smallpox-bird-flu&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.vox.com&amp;#x2F;future-perfect&amp;#x2F;2019&amp;#x2F;3&amp;#x2F;20&amp;#x2F;18260669&amp;#x2F;deadly...&lt;/a&gt;</text></item></parent_chain></comment><story><title>Scientists who say the lab-leak hypothesis for SARS-CoV-2 shouldn&apos;t be ruled out</title><url>https://www.technologyreview.com/2021/03/18/1021030/coronavirus-leak-wuhan-lab-scientists-conspiracy/</url></story>