<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>woeirua</author><text>You should take these findings with a big grain of salt. Remember we don&amp;#x27;t yet even have a causal model of Alzheimer&amp;#x27;s and dementia. Amyloid plaques are strongly associated with Alzheimer&amp;#x27;s but it&amp;#x27;s not clear if they&amp;#x27;re the actual cause or if they&amp;#x27;re just a residual indicator that something else has already gone wrong in the brain.  As a counterpoint to the amyloid hypothesis, we also see amyloid build ups in patients suffering from sleep apnea, and yet they don&amp;#x27;t show the hallmark signs of dementia or Alzheimers [1].&lt;p&gt;[1] &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.sciencedaily.com&amp;#x2F;releases&amp;#x2F;2020&amp;#x2F;09&amp;#x2F;200928103416.htm&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.sciencedaily.com&amp;#x2F;releases&amp;#x2F;2020&amp;#x2F;09&amp;#x2F;200928103416.h...&lt;/a&gt;</text><parent_chain></parent_chain></comment><story><title>Biomarker of Alzheimer&apos;s found to be regulated by sleep cycles</title><url>https://newatlas.com/medical/biomarker-alzheimers-protein-sleep-cycles-rhythm/</url></story>
<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>bluedevil2k</author><text>I&amp;#x27;m curious if sleep aids, whether it&amp;#x27;s OTC like melatonin or Rx like trazodone and Ambien, can help this situation.  Is it just the sleep that&amp;#x27;s beneficial or is it &amp;quot;natural&amp;quot; sleep (that term doesn&amp;#x27;t mean anything, but you get the point of it)?  In other words, should people who have difficulty sleeping look to aids as a way of staving off dementia later in life.</text><parent_chain></parent_chain></comment><story><title>Biomarker of Alzheimer&apos;s found to be regulated by sleep cycles</title><url>https://newatlas.com/medical/biomarker-alzheimers-protein-sleep-cycles-rhythm/</url></story>