<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>bird_monster</author><text>Sure, and that&amp;#x27;s great, but what about the scenarios in which I cannot walk to the park (during 600+ AQI wildfires, as an example), is the reason I&amp;#x27;d like the data on supplementation.</text><parent_chain><item><author>rossdavidh</author><text>There is a long history of taking pills of vitamins and minerals not being as good as getting it the way we evolved for.  We evolved to produce vitamin D by getting sunlight.  We are NOT evolved from nocturnal animals.  A vitamin D supplement might help, but a better idea is to take a walk in the park every day, while the sun is up.</text></item><item><author>shadowmore</author><text>I keep seeing data points like this, but does supplementing vitamin D work? Does it make sense to read things like this and conclude that taking a vitamin D supplement pill daily is a good idea?</text></item><item><author>macawfish</author><text>There is a whole body of research around the ways that vitamin D modulates inflammation, helps regulate calcium homeostasis and strengthens circadian rhythm.  Here is some relevant research:&lt;p&gt;- vitamin D is directly involved in regulating the renin-angiotensin system, including ACE2 expression. ( &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC3999581&amp;#x2F;&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC3999581&amp;#x2F;&lt;/a&gt; )&lt;p&gt;- vitamin D has been shown to have anti-inflammatory activity with respect to cytokines specifically involved in advanced COVID-19 cases ( &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC6164284&amp;#x2F;&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC6164284&amp;#x2F;&lt;/a&gt; )&lt;p&gt;- vitamin D and magnesium insufficiency both cause hypocalcemia, which has been connected to COVID-19 severity: ( &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.researchsquare.com&amp;#x2F;article&amp;#x2F;rs-17575&amp;#x2F;v1&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.researchsquare.com&amp;#x2F;article&amp;#x2F;rs-17575&amp;#x2F;v1&lt;/a&gt; )&lt;p&gt;- magnesium and vitamin K2 also modulate calcium homeostasis ( you can look this one up yourself I need to get off this phone )&lt;p&gt;^^^ this is a snippet from a letter I sent to the local health department. I sure hope someone read it!</text></item></parent_chain></comment><story><title>SARS-CoV-2 positivity rates associated with circulating Vitamin D levels</title><url>https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0239252</url></story>
<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>TheSpiceIsLife</author><text>Here in Tasmania, and given the tone of my skin, in order to get enough sun exposure to provide for my vitamin D requirements...&lt;p&gt;I will spend enough time in the sun to damage my skin and significantly increase the risk of melanoma.</text><parent_chain><item><author>rossdavidh</author><text>There is a long history of taking pills of vitamins and minerals not being as good as getting it the way we evolved for.  We evolved to produce vitamin D by getting sunlight.  We are NOT evolved from nocturnal animals.  A vitamin D supplement might help, but a better idea is to take a walk in the park every day, while the sun is up.</text></item><item><author>shadowmore</author><text>I keep seeing data points like this, but does supplementing vitamin D work? Does it make sense to read things like this and conclude that taking a vitamin D supplement pill daily is a good idea?</text></item><item><author>macawfish</author><text>There is a whole body of research around the ways that vitamin D modulates inflammation, helps regulate calcium homeostasis and strengthens circadian rhythm.  Here is some relevant research:&lt;p&gt;- vitamin D is directly involved in regulating the renin-angiotensin system, including ACE2 expression. ( &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC3999581&amp;#x2F;&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC3999581&amp;#x2F;&lt;/a&gt; )&lt;p&gt;- vitamin D has been shown to have anti-inflammatory activity with respect to cytokines specifically involved in advanced COVID-19 cases ( &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC6164284&amp;#x2F;&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC6164284&amp;#x2F;&lt;/a&gt; )&lt;p&gt;- vitamin D and magnesium insufficiency both cause hypocalcemia, which has been connected to COVID-19 severity: ( &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.researchsquare.com&amp;#x2F;article&amp;#x2F;rs-17575&amp;#x2F;v1&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.researchsquare.com&amp;#x2F;article&amp;#x2F;rs-17575&amp;#x2F;v1&lt;/a&gt; )&lt;p&gt;- magnesium and vitamin K2 also modulate calcium homeostasis ( you can look this one up yourself I need to get off this phone )&lt;p&gt;^^^ this is a snippet from a letter I sent to the local health department. I sure hope someone read it!</text></item></parent_chain></comment><story><title>SARS-CoV-2 positivity rates associated with circulating Vitamin D levels</title><url>https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0239252</url></story>