<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>vikramkr</author><text>Here&amp;#x27;s the original publication. The paper is actually more focused on the 3d engineered brain model and is titled &amp;quot;A 3d human brain-like tissue model of herpes-induced Alzheimer&amp;#x27;s disease&amp;quot;:&lt;p&gt;&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;advances.sciencemag.org&amp;#x2F;content&amp;#x2F;6&amp;#x2F;19&amp;#x2F;eaay8828&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;advances.sciencemag.org&amp;#x2F;content&amp;#x2F;6&amp;#x2F;19&amp;#x2F;eaay8828&lt;/a&gt;&lt;p&gt;The publication actually seems to highlight the demonstration of the 3d brain Alzheimers model as more of what the accomplishment of the paper is (as compared to a demonstration of a herpes&amp;#x2F;Alzheimers link). Studying Alzheimer&amp;#x27;s is really difficult because the mouse models etc that we have today are particularly poor for this disease case, which means we can barely rely on any preclinical work done in these models in determing whether or not a drug is going to work in clinical trials. Better models to study Alzheimer&amp;#x27;s will be very important in fighting the disease. For more publications on the 3d model, here is what the paper cited in its methods section for how they made the brain-like structures:&lt;p&gt;&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.sciencedirect.com&amp;#x2F;science&amp;#x2F;article&amp;#x2F;pii&amp;#x2F;S2213671116301412&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.sciencedirect.com&amp;#x2F;science&amp;#x2F;article&amp;#x2F;pii&amp;#x2F;S221367111...&lt;/a&gt;&lt;p&gt;&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.nature.com&amp;#x2F;articles&amp;#x2F;nprot.2015.091&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.nature.com&amp;#x2F;articles&amp;#x2F;nprot.2015.091&lt;/a&gt;</text><parent_chain></parent_chain></comment><story><title>Using human brain tissue in lab, researchers show herpes link to Alzheimer’s</title><url>https://www.statnews.com/2020/05/06/researchers-show-herpes-link-to-alzheimers/</url></story>
<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>weiming</author><text>HSV always seemed particularly poorly understood in the society to me, e.g. with many people getting it as children due to careless parents&amp;#x2F;extended family, and the benign branding of &amp;quot;cold sore&amp;quot; as if it is related to a cold. Given that the vaccine for 1 or 2 has proved to be extremely challenging, always wondered if the public simply being more well-informed on this topic could help reduce the incidence in the population.&lt;p&gt;Asymptomatic shedding of HSV has to be considered, too. &lt;i&gt;&amp;quot;Transmission commonly occurs from contact with an infected partner who does not have visible lesions and who may not know that he or she is infected. In persons with asymptomatic HSV-2 infections, genital HSV shedding occurs on 10.2% of days, compared to 20.1% of days among those with symptomatic infections.&amp;quot;&lt;/i&gt; (&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.cdc.gov&amp;#x2F;std&amp;#x2F;herpes&amp;#x2F;stdfact-herpes-detailed.htm&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.cdc.gov&amp;#x2F;std&amp;#x2F;herpes&amp;#x2F;stdfact-herpes-detailed.htm&lt;/a&gt;)</text><parent_chain></parent_chain></comment><story><title>Using human brain tissue in lab, researchers show herpes link to Alzheimer’s</title><url>https://www.statnews.com/2020/05/06/researchers-show-herpes-link-to-alzheimers/</url></story>