<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>CompelTechnic</author><text>Do the mood-changing effects of the TRT medication have any resemblance to the mood-changing effects of exercise?&lt;p&gt;I often notice that in the days during&amp;#x2F;following good exercise, I not only feel happier, but also more &amp;quot;virile&amp;quot; for lack of a better word, and also more aggressive. I partially attribute this to testosterone increasing.&lt;p&gt;Do you have any particular opinions on global trends in sperm count reduction?
&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.scientificamerican.com&amp;#x2F;article&amp;#x2F;sperm-count-dropping-in-western-world&amp;#x2F;&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.scientificamerican.com&amp;#x2F;article&amp;#x2F;sperm-count-dropp...&lt;/a&gt;</text><parent_chain><item><author>throwawaytrt</author><text>(throw away because some employers know my actual)&lt;p&gt;I have been on TRT for several years as a result of a damaged pituitary from a tumor that was removed.
I have played with the dosages alongside my doctor, and definitely found that (to a certain extent) it really has an effect on my mood.&lt;p&gt;From personal experience, I don&amp;#x27;t know if it would call it an anti-depressent, but it seems to stifle anxiety at the right doses.&lt;p&gt;Some people say it&amp;#x27;s a &amp;quot;confidence drug&amp;quot; but my opinion is it performs more like an anti-anxiety drug.&lt;p&gt;I can have a terrible week of work with little sleep, bump my dose a bit and I calm down - as long as the dose is not high enough to put my estrogen (e2) levels out of whack.&lt;p&gt;Dosage and duration are extremely important. If you mess either up it can make you moody and full of anxiety.&lt;p&gt;Many doctors today are incredibly unskilled and uneducated regarding hormones. I know many doctors perscribe trt in one shot per two weeks, and even one shot per month. I had to go through four doctors to find my current who is a specialist and very well educated.&lt;p&gt;With a half life of about 6 days, test-c should be administered at MINIMUM weekly. Ideally bi-weekly. Dosage should be enough to get you in the 600-1000ng&amp;#x2F;dl range.&lt;p&gt;You also need to carefully observe the hormones that coorelate closely with testosterone, like e2. If that goes to high (aka high converter) your mood will be worse.&lt;p&gt;Some people will also see a rise in hematocrit which thickens the blood and can be a risk factor for a number of things. I do not have this issue as my hematocrit is very stable on or off trt.&lt;p&gt;My blood pressure has actually dropped on TRT.&lt;p&gt;If you can do the balancing act it is overall very good.&lt;p&gt;-- Feel free to ask me anything about TRT and it&amp;#x27;s effects on mood, hormones, etc. I will try to answer. I have been researching it for years.</text></item></parent_chain></comment><story><title>Testosterone Treatment and Alleviation of Depressive Symptoms in Men</title><url>https://jamanetwork.com/journals/jamapsychiatry/article-abstract/2712976?widget=personalizedcontent&amp;previousarticle=2712974</url></story>
<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>Florin_Andrei</author><text>Aren&amp;#x27;t there ways to also control the level of e2? I thought the conversion pathway is susceptible to various suppressors.</text><parent_chain><item><author>throwawaytrt</author><text>(throw away because some employers know my actual)&lt;p&gt;I have been on TRT for several years as a result of a damaged pituitary from a tumor that was removed.
I have played with the dosages alongside my doctor, and definitely found that (to a certain extent) it really has an effect on my mood.&lt;p&gt;From personal experience, I don&amp;#x27;t know if it would call it an anti-depressent, but it seems to stifle anxiety at the right doses.&lt;p&gt;Some people say it&amp;#x27;s a &amp;quot;confidence drug&amp;quot; but my opinion is it performs more like an anti-anxiety drug.&lt;p&gt;I can have a terrible week of work with little sleep, bump my dose a bit and I calm down - as long as the dose is not high enough to put my estrogen (e2) levels out of whack.&lt;p&gt;Dosage and duration are extremely important. If you mess either up it can make you moody and full of anxiety.&lt;p&gt;Many doctors today are incredibly unskilled and uneducated regarding hormones. I know many doctors perscribe trt in one shot per two weeks, and even one shot per month. I had to go through four doctors to find my current who is a specialist and very well educated.&lt;p&gt;With a half life of about 6 days, test-c should be administered at MINIMUM weekly. Ideally bi-weekly. Dosage should be enough to get you in the 600-1000ng&amp;#x2F;dl range.&lt;p&gt;You also need to carefully observe the hormones that coorelate closely with testosterone, like e2. If that goes to high (aka high converter) your mood will be worse.&lt;p&gt;Some people will also see a rise in hematocrit which thickens the blood and can be a risk factor for a number of things. I do not have this issue as my hematocrit is very stable on or off trt.&lt;p&gt;My blood pressure has actually dropped on TRT.&lt;p&gt;If you can do the balancing act it is overall very good.&lt;p&gt;-- Feel free to ask me anything about TRT and it&amp;#x27;s effects on mood, hormones, etc. I will try to answer. I have been researching it for years.</text></item></parent_chain></comment><story><title>Testosterone Treatment and Alleviation of Depressive Symptoms in Men</title><url>https://jamanetwork.com/journals/jamapsychiatry/article-abstract/2712976?widget=personalizedcontent&amp;previousarticle=2712974</url></story>