<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>CapstanRoller</author><text>&amp;gt;I feel great and my brain seems to be functioning as well as when I was in my 20’s&lt;p&gt;&amp;gt;but my untreated ADHD seems to be getting worse.&lt;p&gt;I had very similar results after taking ketamine for treatment-resistant depression. It eliminated all my compulsive tendencies for getting cheap dopamine hits (food, doomscrolling, etc), reset my tolerance to everything (caffeine, ADHD meds, alcohol), and made my ADHD worse while improving throughput and ability to Get Shit Done.&lt;p&gt;I wonder if they affect the same parts of the brain in a roundabout way? Ketamine is also used to treat addiction (opioids, primarily).&lt;p&gt;Do you experience any anhedonia while using Mounjaro? Did your overall pleasure response get blunted?</text><parent_chain><item><author>jmpman</author><text>I’ve been on Mounjaro since August. Down almost 60lbs, and it’s been a life changer. Have I had some gastrointestinal issues, sure, but expected. I feel great and my brain seems to be functioning as well as when I was in my 20’s. Now, when I go to the bar with friends, I end up having maybe 2 beers and although enjoyable, I don’t feel that light switch turning on which encourages me to drink more. Can I force myself to keep drinking, say if my good friends are in town and we’re going out all night? Sure, but there’s some reward center that’s no longer lighting up. I just get drunker, but it’s not more pleasurable. I was never a big drinker at home by myself. Maybe a glass of wine or two with dinner if my in-laws are coming over. Now I’ve literally had zero drinks at home by myself. Seems to have started changing about 3 month in.&lt;p&gt;Work also seems more interesting, but my untreated ADHD seems to be getting worse.</text></item></parent_chain></comment><story><title>Ozempic drug supresses desire to smoke, drink and more?</title><url>https://www.theatlantic.com/health/archive/2023/05/ozempic-addictive-behavior-drinking-smoking/674098/</url></story>
<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>helsinkiandrew</author><text>&amp;gt;  but there’s some reward center that’s no longer lighting up.&lt;p&gt;Do you find other pleasures (non food and drink) as enjoyable? Interesting to hear if it’s selective or dampens everything.</text><parent_chain><item><author>jmpman</author><text>I’ve been on Mounjaro since August. Down almost 60lbs, and it’s been a life changer. Have I had some gastrointestinal issues, sure, but expected. I feel great and my brain seems to be functioning as well as when I was in my 20’s. Now, when I go to the bar with friends, I end up having maybe 2 beers and although enjoyable, I don’t feel that light switch turning on which encourages me to drink more. Can I force myself to keep drinking, say if my good friends are in town and we’re going out all night? Sure, but there’s some reward center that’s no longer lighting up. I just get drunker, but it’s not more pleasurable. I was never a big drinker at home by myself. Maybe a glass of wine or two with dinner if my in-laws are coming over. Now I’ve literally had zero drinks at home by myself. Seems to have started changing about 3 month in.&lt;p&gt;Work also seems more interesting, but my untreated ADHD seems to be getting worse.</text></item></parent_chain></comment><story><title>Ozempic drug supresses desire to smoke, drink and more?</title><url>https://www.theatlantic.com/health/archive/2023/05/ozempic-addictive-behavior-drinking-smoking/674098/</url></story>