<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>erentz</author><text>&amp;gt; this pill will turn you into Bradley Cooper in Limitless&lt;p&gt;That’s quite a sales pitch! Propranolol worked for me for occasional use for stage fright scenarios. It was an amazing feeling the first couple of times to be able to go into those situations without the anxiety. But far from the Limitless example, for me a couple of hours after taking it I would slow down mentally and a few hours after taking it I would be exhausted and absolutely done for the day.</text><parent_chain><item><author>ransom1538</author><text>If you are out there and suffer daily &amp;#x27;stage fright&amp;#x27; or serious social anxiety - propranolol is the drug for you.  That weird fear that sweeps over you before a conversation - just doesn&amp;#x27;t happen.  Need to talk in front of 50 people in 25 minutes? No problem. If you are crippled by social anxiety - this pill will turn you into Bradley Cooper in Limitless.</text></item><item><author>petercooper</author><text>As someone who has used propranolol on and off over the past few years, the thing that intrigues me here is that propranolol works well in this instance &lt;i&gt;due to crossing the blood&amp;#x2F;brain barrier&lt;/i&gt; as opposed to other beta blockers that do not.&lt;p&gt;The use of beta blockers in anxiety is commonly associated with reducing the effects of stress on heart rate and blood pressure, not necessarily on affecting the brain directly which appears to be happening here. That is, beta blockers are usually a &lt;i&gt;band aid&lt;/i&gt; rather than a fix, so this discovery is exciting.&lt;p&gt;(As an aside, if you suffer from unusual levels of physical response to certain stimuli while intellectually remaining calm or indifferent, propranolol may be worth investigating for you as it has helped me a lot. At your own risk, of course.)</text></item></parent_chain></comment><story><title>Single-dose propranolol tied to ‘selective erasure’ of anxiety disorders</title><url>https://www.mdedge.com/psychiatry/article/191908/anxiety-disorders/single-dose-propranolol-tied-selective-erasure-anxiety</url></story>
<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>IAmGraydon</author><text>Maybe I’m an outlier, but it had absolutely no effect on me for public speaking or social situations. I was prescribed a lot of it, tried for years and even still have some sitting around. I envy those who get the effects you describe.</text><parent_chain><item><author>ransom1538</author><text>If you are out there and suffer daily &amp;#x27;stage fright&amp;#x27; or serious social anxiety - propranolol is the drug for you.  That weird fear that sweeps over you before a conversation - just doesn&amp;#x27;t happen.  Need to talk in front of 50 people in 25 minutes? No problem. If you are crippled by social anxiety - this pill will turn you into Bradley Cooper in Limitless.</text></item><item><author>petercooper</author><text>As someone who has used propranolol on and off over the past few years, the thing that intrigues me here is that propranolol works well in this instance &lt;i&gt;due to crossing the blood&amp;#x2F;brain barrier&lt;/i&gt; as opposed to other beta blockers that do not.&lt;p&gt;The use of beta blockers in anxiety is commonly associated with reducing the effects of stress on heart rate and blood pressure, not necessarily on affecting the brain directly which appears to be happening here. That is, beta blockers are usually a &lt;i&gt;band aid&lt;/i&gt; rather than a fix, so this discovery is exciting.&lt;p&gt;(As an aside, if you suffer from unusual levels of physical response to certain stimuli while intellectually remaining calm or indifferent, propranolol may be worth investigating for you as it has helped me a lot. At your own risk, of course.)</text></item></parent_chain></comment><story><title>Single-dose propranolol tied to ‘selective erasure’ of anxiety disorders</title><url>https://www.mdedge.com/psychiatry/article/191908/anxiety-disorders/single-dose-propranolol-tied-selective-erasure-anxiety</url></story>