<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>layer8</author><text>Cache invalidation, probably.</text><parent_chain><item><author>aftergibson</author><text>What&amp;#x27;s the 3rd way?</text></item><item><author>findthewords</author><text>There are three ways to flush acute glutamate buildup from the brain:&lt;p&gt;1. Exercise. The brain can direct glutamate to be used as an energy source to dispose of excess amounts. Glutamate naturally flows by diffusion from areas of high concentration (in blood vessel wall cells) through the blood vessel wall into the circulating bloodstream, where the concentration is lower.&lt;p&gt;2. Eat a tuna sandwich or drink an energy drink. Vitamin B6 is a a coenzyme in the synthesis of the inhibitory neurotransmitter GABA from glutamate. Thinking  jobs is also coincident with rising popularity of energy drinks from 2000s onwards.&lt;p&gt;The Economist is most likely regurgitating Nature:&lt;p&gt;11 August 2022
Why thinking hard makes us feel tired
&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.nature.com&amp;#x2F;articles&amp;#x2F;d41586-022-02161-5&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.nature.com&amp;#x2F;articles&amp;#x2F;d41586-022-02161-5&lt;/a&gt;</text></item></parent_chain></comment><story><title>Thinking hard makes the brain tired</title><url>https://www.economist.com/science-and-technology/2022/08/11/how-thinking-hard-makes-the-brain-tired</url></story>
<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>latortuga</author><text>It&amp;#x27;s gotta be sleep, right?</text><parent_chain><item><author>aftergibson</author><text>What&amp;#x27;s the 3rd way?</text></item><item><author>findthewords</author><text>There are three ways to flush acute glutamate buildup from the brain:&lt;p&gt;1. Exercise. The brain can direct glutamate to be used as an energy source to dispose of excess amounts. Glutamate naturally flows by diffusion from areas of high concentration (in blood vessel wall cells) through the blood vessel wall into the circulating bloodstream, where the concentration is lower.&lt;p&gt;2. Eat a tuna sandwich or drink an energy drink. Vitamin B6 is a a coenzyme in the synthesis of the inhibitory neurotransmitter GABA from glutamate. Thinking  jobs is also coincident with rising popularity of energy drinks from 2000s onwards.&lt;p&gt;The Economist is most likely regurgitating Nature:&lt;p&gt;11 August 2022
Why thinking hard makes us feel tired
&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.nature.com&amp;#x2F;articles&amp;#x2F;d41586-022-02161-5&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.nature.com&amp;#x2F;articles&amp;#x2F;d41586-022-02161-5&lt;/a&gt;</text></item></parent_chain></comment><story><title>Thinking hard makes the brain tired</title><url>https://www.economist.com/science-and-technology/2022/08/11/how-thinking-hard-makes-the-brain-tired</url></story>