<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>guyt00</author><text>Problems with this terrible title:&lt;p&gt;1. In vitro petri dish testing is a million light years away from showing a compound works in humans.&lt;p&gt;2. This is a particularly bad problem in brain diseases as getting your compound to cross the blood-brain barrier in correct therapeutic quantities is extremely difficult.&lt;p&gt;3. We have lots of direct antibodies that kill beta amyloid in vivo that are very advanced in human trials. The problem now is that they often cause micro-damage when removing various forms of amyloid protein or have been shown to be administered far too late when the damage is already done.&lt;p&gt;4. It&amp;#x27;s still not clear that beta amyloid is even the main causal agent of Alzheimers!&lt;p&gt;In general, if you see someone touting a low effort, pre-clinical study as major medical breakthrough, start hitting the downvote button. I&amp;#x27;m disappointed this even got to the main page.</text><parent_chain></parent_chain></comment><story><title>Marijuana Compound Removes Toxic Alzheimer’s Protein from the Brain</title><url>https://futurism.com/marijuana-compound-removes-toxic-alzheimers-protein-from-the-brain/</url></story>
<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>chillingeffect</author><text>article is a value-added summary of:
&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.sciencedaily.com&amp;#x2F;releases&amp;#x2F;2016&amp;#x2F;06&amp;#x2F;160629095609.htm&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.sciencedaily.com&amp;#x2F;releases&amp;#x2F;2016&amp;#x2F;06&amp;#x2F;160629095609.h...&lt;/a&gt;&lt;p&gt;which is based on this press release:
&lt;a href=&quot;http:&amp;#x2F;&amp;#x2F;www.salk.edu&amp;#x2F;news-release&amp;#x2F;cannabinoids-remove-plaque-forming-alzheimers-proteins-from-brain-cells&amp;#x2F;&quot; rel=&quot;nofollow&quot;&gt;http:&amp;#x2F;&amp;#x2F;www.salk.edu&amp;#x2F;news-release&amp;#x2F;cannabinoids-remove-plaque-...&lt;/a&gt;&lt;p&gt;original paper here:
&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.nature.com&amp;#x2F;articles&amp;#x2F;npjamd201612&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.nature.com&amp;#x2F;articles&amp;#x2F;npjamd201612&lt;/a&gt;
&amp;quot;Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids&amp;quot;&lt;p&gt;original paper:
&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.nature.com&amp;#x2F;articles&amp;#x2F;npjamd201612.pdf&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.nature.com&amp;#x2F;articles&amp;#x2F;npjamd201612.pdf&lt;/a&gt;</text><parent_chain></parent_chain></comment><story><title>Marijuana Compound Removes Toxic Alzheimer’s Protein from the Brain</title><url>https://futurism.com/marijuana-compound-removes-toxic-alzheimers-protein-from-the-brain/</url></story>