<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>r930</author><text>My speculation, as with others, is that Alzheimer&amp;#x27;s disease (as well as many other slow progressing diseases) is just a metabolic disease, inline with the &amp;quot;type 3 diabetes&amp;quot; comments.&lt;p&gt;Look into supporting mitochondria health [0] and the glymphatic system [1]: good diet (with fasting), light to moderate exercise, sleep and wake at the same time each day for circadian rhythm training, reduce unnecessary stress.&lt;p&gt;Once the basics have been implemented, some supplements could help to further support cell function if needed: Longevity supplements that Dr David Sinclair takes [2], boosting cellular glutathione stores, with NACET, glycine, selenium [3]&lt;p&gt;[0] &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC4684129&amp;#x2F;&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC4684129&amp;#x2F;&lt;/a&gt;
[1] &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC7698404&amp;#x2F;&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC7698404&amp;#x2F;&lt;/a&gt;
[2] &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;novoslabs.com&amp;#x2F;best-anti-aging-supplements-that-harvard-scientist-david-sinclair-takes&amp;#x2F;&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;novoslabs.com&amp;#x2F;best-anti-aging-supplements-that-harva...&lt;/a&gt;
[3] &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC7889054&amp;#x2F;&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC7889054&amp;#x2F;&lt;/a&gt;</text><parent_chain><item><author>kyaghmour</author><text>As someone who has a close relative diagnosed with this disease, I&amp;#x27;m always on the lookout for new information. So this is interesting.&lt;p&gt;One area I&amp;#x27;m particularly interested in is the correlation to diabetes. It&amp;#x27;s a factor that I found being mentioned here and there in some references. In the immediate case that interests me, there&amp;#x27;s a 20+ year history of type 2 diabetes and a recent scan showed severe bilateral hypocampal atrophy. When googling for a link between the two I found this:
&amp;quot;Lower insulin secretion was significantly associated with HPGA (hippocampal and parahippocampal gyrus atrophy) in patients with type 2 diabetes mellitus. The results of this study support the hypothesis that insulin‐signaling abnormalities are involved in the pathophysiology of Alzheimer’s disease.&amp;quot;
&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC8504906&amp;#x2F;&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC8504906&amp;#x2F;&lt;/a&gt;&lt;p&gt;Yet, the mechanism of this, if indeed there&amp;#x27;s causality (not just correlation) does not seem to be known.</text></item></parent_chain></comment><story><title>What causes Alzheimer&apos;s? Scientists are rethinking the answer</title><url>https://www.quantamagazine.org/what-causes-alzheimers-scientists-are-rethinking-the-answer-20221208/</url></story>
<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>lucidrains</author><text>in some medical circles, alzheimers is referred to as &amp;quot;type 3 diabetes&amp;quot;</text><parent_chain><item><author>kyaghmour</author><text>As someone who has a close relative diagnosed with this disease, I&amp;#x27;m always on the lookout for new information. So this is interesting.&lt;p&gt;One area I&amp;#x27;m particularly interested in is the correlation to diabetes. It&amp;#x27;s a factor that I found being mentioned here and there in some references. In the immediate case that interests me, there&amp;#x27;s a 20+ year history of type 2 diabetes and a recent scan showed severe bilateral hypocampal atrophy. When googling for a link between the two I found this:
&amp;quot;Lower insulin secretion was significantly associated with HPGA (hippocampal and parahippocampal gyrus atrophy) in patients with type 2 diabetes mellitus. The results of this study support the hypothesis that insulin‐signaling abnormalities are involved in the pathophysiology of Alzheimer’s disease.&amp;quot;
&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC8504906&amp;#x2F;&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC8504906&amp;#x2F;&lt;/a&gt;&lt;p&gt;Yet, the mechanism of this, if indeed there&amp;#x27;s causality (not just correlation) does not seem to be known.</text></item></parent_chain></comment><story><title>What causes Alzheimer&apos;s? Scientists are rethinking the answer</title><url>https://www.quantamagazine.org/what-causes-alzheimers-scientists-are-rethinking-the-answer-20221208/</url></story>