<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>0cVlTeIATBs</author><text>&amp;quot;Goldman Sachs asks in biotech research report: ‘Is curing patients a sustainable business model?’&amp;quot;&lt;p&gt;&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.cnbc.com&amp;#x2F;2018&amp;#x2F;04&amp;#x2F;11&amp;#x2F;goldman-asks-is-curing-patients-a-sustainable-business-model.html&quot; rel=&quot;nofollow noreferrer&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.cnbc.com&amp;#x2F;2018&amp;#x2F;04&amp;#x2F;11&amp;#x2F;goldman-asks-is-curing-patie...&lt;/a&gt;</text><parent_chain><item><author>hrkfmud50k</author><text>&amp;gt; After a single application, this strain persists in the mouth indefinitely, hedging out cavity-causing bacteria&lt;p&gt;&amp;gt; but the developing company declined to go to market, and instead pivoted to selling once-daily probiotic mouthwash.&lt;p&gt;sounds like they preferred to sell a recurring subscription vs a one-time sale</text></item><item><author>rudyfink</author><text>Why do you think the company never took it to market past testing?&lt;p&gt;And thank you for looking into this. I recall reading about experiments on the modified bacteria years ago, but then I forgot about it.  Until I read your page, I had not realized it died on the vine.</text></item><item><author>akrolsmir</author><text>Oh wow -- totally didn&amp;#x27;t expect one of our grant proposals to be trending on HN! I&amp;#x27;m Austin, cofounder at Manifund; we just launched our regranting program last week (&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;forum.effectivealtruism.org&amp;#x2F;posts&amp;#x2F;RMXctNAksBgXgoszY&amp;#x2F;announcing-manifund-regrants&quot; rel=&quot;nofollow noreferrer&quot;&gt;https:&amp;#x2F;&amp;#x2F;forum.effectivealtruism.org&amp;#x2F;posts&amp;#x2F;RMXctNAksBgXgoszY&amp;#x2F;...&lt;/a&gt;) and are currently looking out for cool grants (like this one!) to fund.&lt;p&gt;Happy to answer any questions!</text></item></parent_chain></comment><story><title>Recreate the cavity-preventing GMO bacteria BCS3-L1 from precursor</title><url>https://manifund.org/projects/recreate-the-cavity-preventing-gmo-bacteria-bcs3-l1-from-precursor-</url></story>
<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>autoexec</author><text>Here&amp;#x27;s hoping that someday someone who cares more about promoting health than padding wallets will take this idea and use it to bring the masses something they can apply once at a low price.</text><parent_chain><item><author>hrkfmud50k</author><text>&amp;gt; After a single application, this strain persists in the mouth indefinitely, hedging out cavity-causing bacteria&lt;p&gt;&amp;gt; but the developing company declined to go to market, and instead pivoted to selling once-daily probiotic mouthwash.&lt;p&gt;sounds like they preferred to sell a recurring subscription vs a one-time sale</text></item><item><author>rudyfink</author><text>Why do you think the company never took it to market past testing?&lt;p&gt;And thank you for looking into this. I recall reading about experiments on the modified bacteria years ago, but then I forgot about it.  Until I read your page, I had not realized it died on the vine.</text></item><item><author>akrolsmir</author><text>Oh wow -- totally didn&amp;#x27;t expect one of our grant proposals to be trending on HN! I&amp;#x27;m Austin, cofounder at Manifund; we just launched our regranting program last week (&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;forum.effectivealtruism.org&amp;#x2F;posts&amp;#x2F;RMXctNAksBgXgoszY&amp;#x2F;announcing-manifund-regrants&quot; rel=&quot;nofollow noreferrer&quot;&gt;https:&amp;#x2F;&amp;#x2F;forum.effectivealtruism.org&amp;#x2F;posts&amp;#x2F;RMXctNAksBgXgoszY&amp;#x2F;...&lt;/a&gt;) and are currently looking out for cool grants (like this one!) to fund.&lt;p&gt;Happy to answer any questions!</text></item></parent_chain></comment><story><title>Recreate the cavity-preventing GMO bacteria BCS3-L1 from precursor</title><url>https://manifund.org/projects/recreate-the-cavity-preventing-gmo-bacteria-bcs3-l1-from-precursor-</url></story>