<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>ch4s3</author><text>&amp;gt; mRNA is a new, unknown technology&lt;p&gt;This is untrue, researchers have been testing various mRNA therapies on people for 30 years, with it being first done in vitro in 1990 then in vivo in 1992 [1]. Lipid nano particles were first used around the same time.&lt;p&gt;&amp;gt; the vaccine was rushed faster to public access than any other vaccine before&lt;p&gt;This is only true if you ignore the development of the mRNA vaccine platform for flu, rabies, and zika that predated the pandemic by years. The novel development here was swapping in new protein encoding. If you look at this as a continuation of that process, then it&amp;#x27;s only a little faster than normal, and a lot of that was due to the FDA switching sequential steps in the process to be parallel.&lt;p&gt;&amp;gt; We have absolutely no idea if there are any long term side effects of these vaccines.&lt;p&gt;This isn&amp;#x27;t a meaningful claim for 2 key reasons. There has never been a vaccine that had serious side effects that did show up shortly after vaccination[2]. The history of mRNA treatments began as an experiment in gene therapy, but has largely ben abandoned because the effects never lasted long enough. As of 2020 this is an ongoing area of research[3]. No one has figure out how to stabilize mRNA so that it has long lasting effects.&lt;p&gt;&amp;gt; Both candidates Biden and Harris&lt;p&gt;They&amp;#x27;re both craven, ignorant politicians, who cares what they said when the other guy was in power.&lt;p&gt;[1] &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.nature.com&amp;#x2F;articles&amp;#x2F;nrd.2017.243&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.nature.com&amp;#x2F;articles&amp;#x2F;nrd.2017.243&lt;/a&gt;&lt;p&gt;[2] &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.cdc.gov&amp;#x2F;vaccinesafety&amp;#x2F;concerns&amp;#x2F;concerns-history.html&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.cdc.gov&amp;#x2F;vaccinesafety&amp;#x2F;concerns&amp;#x2F;concerns-history....&lt;/a&gt;&lt;p&gt;[3] &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC7076378&amp;#x2F;&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC7076378&amp;#x2F;&lt;/a&gt;&lt;p&gt;[edit] All that said, I am no pro mandate but seriously you should all voluntarily go get vaccinated IMHO.</text><parent_chain><item><author>SirensOfTitan</author><text>To preface: I got the vaccine months ago (as soon as I had access), I&amp;#x27;m a big believer in vaccines.&lt;p&gt;With that being said, this policy doesn&amp;#x27;t sit well with me. None of the currently available vaccines in the US are FDA approved. Of course, a lot of people have received those vaccines, but I also don&amp;#x27;t necessarily fault individuals for feeling hesitant (the nuance here is that I think people ought to get the vaccine).  mRNA is a new, unknown technology, and the vaccine was rushed faster to public access than any other vaccine before. We have absolutely no idea if there are any long term side effects of these vaccines.&lt;p&gt;Both candidates Biden and Harris expressed the need for full trials and transparency in regard to the vaccine &lt;i&gt;before&lt;/i&gt; they were in office, then changed their tune after (see: &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;twitter.com&amp;#x2F;pbhushan1&amp;#x2F;status&amp;#x2F;1416969060890210305&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;twitter.com&amp;#x2F;pbhushan1&amp;#x2F;status&amp;#x2F;1416969060890210305&lt;/a&gt;).  Biden says:&lt;p&gt;&amp;gt; When we finally do, God willing, get a vaccine, Who’s going to take the shot? Who’s going to take the shot? You going to be the first one to say, “Put me — sign me up, they now say it’s OK”?&lt;p&gt;If the vaccine is as effective as it seems, then this decision feels positively nanny state to me. It takes away an individual&amp;#x27;s agency to inform themselves of the risks on both sides and make an informed decision.</text></item></parent_chain></comment><story><title>NYC to mandate proof of vaccination for many indoor settings</title><url>https://nypost.com/2021/08/03/nyc-to-mandate-proof-of-vaccination-for-many-indoor-settings/</url></story>
<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>TomVDB</author><text>&amp;gt; None of the currently available vaccines in the US are FDA approved.&lt;p&gt;On one hand, I can&amp;#x27;t wait for the Pfizer vaccine to be fully FDA approved in September. On the other, everybody who uses that argument today will simply forget about it and move goalposts.</text><parent_chain><item><author>SirensOfTitan</author><text>To preface: I got the vaccine months ago (as soon as I had access), I&amp;#x27;m a big believer in vaccines.&lt;p&gt;With that being said, this policy doesn&amp;#x27;t sit well with me. None of the currently available vaccines in the US are FDA approved. Of course, a lot of people have received those vaccines, but I also don&amp;#x27;t necessarily fault individuals for feeling hesitant (the nuance here is that I think people ought to get the vaccine).  mRNA is a new, unknown technology, and the vaccine was rushed faster to public access than any other vaccine before. We have absolutely no idea if there are any long term side effects of these vaccines.&lt;p&gt;Both candidates Biden and Harris expressed the need for full trials and transparency in regard to the vaccine &lt;i&gt;before&lt;/i&gt; they were in office, then changed their tune after (see: &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;twitter.com&amp;#x2F;pbhushan1&amp;#x2F;status&amp;#x2F;1416969060890210305&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;twitter.com&amp;#x2F;pbhushan1&amp;#x2F;status&amp;#x2F;1416969060890210305&lt;/a&gt;).  Biden says:&lt;p&gt;&amp;gt; When we finally do, God willing, get a vaccine, Who’s going to take the shot? Who’s going to take the shot? You going to be the first one to say, “Put me — sign me up, they now say it’s OK”?&lt;p&gt;If the vaccine is as effective as it seems, then this decision feels positively nanny state to me. It takes away an individual&amp;#x27;s agency to inform themselves of the risks on both sides and make an informed decision.</text></item></parent_chain></comment><story><title>NYC to mandate proof of vaccination for many indoor settings</title><url>https://nypost.com/2021/08/03/nyc-to-mandate-proof-of-vaccination-for-many-indoor-settings/</url></story>