<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>A_D_E_P_T</author><text>Of course it&amp;#x27;s possible to use this sort of therapy to prevent disease, by knocking out single genes associated with the development of disease.&lt;p&gt;It&amp;#x27;s just as possible to silence single genes that, when silenced, may elicit substantial positive effects in healthy adults.  Part of George Church&amp;#x27;s list, by no means comprehensive, is:&lt;p&gt;MSTN -&amp;#x2F;- Lean muscle growth&lt;p&gt;SCN9A -&amp;#x2F;- Insensitivity to pain&lt;p&gt;ABCC11 -&amp;#x2F;- Low Odor production&lt;p&gt;CCR5, FUT2 -&amp;#x2F;- Virus resistance&lt;p&gt;PCSK9 -&amp;#x2F;- Low coronary disease&lt;p&gt;SLC30A8 -&amp;#x2F;+ Low T2 Diabetes&lt;p&gt;There are many others. Knocking out ACTN3, for instance, might remodel skeletal muscle for better endurance performance, and certain athletes don&amp;#x27;t express the gene.</text><parent_chain></parent_chain></comment><story><title>An epigenetic editor to silence genes</title><url>https://www.science.org/doi/10.1126/science.adq3334</url></story>
<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>ProjectArcturis</author><text>Very impressive work. Just in mice so far but this looks very promising for Huntington&amp;#x27;s in particular.</text><parent_chain></parent_chain></comment><story><title>An epigenetic editor to silence genes</title><url>https://www.science.org/doi/10.1126/science.adq3334</url></story>