<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>peter422</author><text>The vaccines did not skip any safety tests, they just compressed the schedule because millions of people were dying of a preventable disease.&lt;p&gt;At this point hundreds of millions of people have taken the various vaccines.  There clearly are no major short or medium term effects (other than the reported, rare side effects).&lt;p&gt;Also you can literally read all the documents provided to the FDA concerning the efficacy and safety of the vaccines.  There isn&amp;#x27;t a giant conspiracy, all the original studies and data are in the open.</text><parent_chain><item><author>throwkeep</author><text>There are valid concerns and a difficult risk benefit analysis for some cohorts, I think. What are your thoughts on this? Put yourself in her shoes:&lt;p&gt;&amp;quot;I held off on a COVID vaccine because I wanted to wait for data with positive signals for both pregnancy in the short term and long-run fertility. I’m trying to get pregnant, and those are the two things I care about most.&lt;p&gt;Vaccine data is so politicized that it’s actually somewhat difficult to find full studies, results discussions or data sets as a layman, because every search term redirects you to “yes, get vaccinated right now, your concerns are merely ignorance”&lt;p&gt;The other study that concerns me shows that the vaccine’s lipid nanoparticles— which carry the RNA instructions for the spike protein — move beyond the deltoid muscle they’re injected into and accumulate in other tissues, and seem to accumulate in ovarian tissue preferentially.&lt;p&gt;That study looked at a &lt;i&gt;very&lt;/i&gt; small sample, but given what we &lt;i&gt;think&lt;/i&gt; we know about the spike protein — it likely causes some degree of tissue damage on its own, independent of the virus — it’s something that definitely demands further study&lt;p&gt;Anyway, I feel like I need to come clean at this point. For a long time I was avoiding the vaccine because I wanted to hold out for more data. Now I’m actively choosing not to get it because what I’ve seen is providing the opposite of a positive safety signal for my purposes.&lt;p&gt;It’s &lt;i&gt;really&lt;/i&gt; important that I clarify I’m not at a high risk of exposure. I generally don’t work or even socialize outside my home. Lockdown life frankly doesn’t look that different from my preferred lifestyle. If I were a high exposure risk I would think about this differently&lt;p&gt;I’m in the process of getting a prescription for prophylactic ivermectin, which has also become extremely politicized — to the point of becoming a censored topic on some platforms. I’m not giving advice, here. I’m not making broader efficacy claims. I’m just trying to be honest&lt;p&gt;COVID is no joke. You do not want to get COVID. “Long COVID” symptoms should concern you even if you don’t think an infection would kill you. But the vaccines are very new and skipped a great deal of otherwise required safety testing, and some of this data is really worrisome.&amp;quot;&lt;p&gt;&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;mobile.twitter.com&amp;#x2F;webdevMason&amp;#x2F;status&amp;#x2F;1405649896212819975&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;mobile.twitter.com&amp;#x2F;webdevMason&amp;#x2F;status&amp;#x2F;14056498962128...&lt;/a&gt;</text></item><item><author>JohnJamesRambo</author><text>I wish I could get people that are avoiding the COVID vaccine “because we don’t know what the long term effects are” to realize that we have real data showing that there are long term effects from getting full blown COVID.  You don’t want a tiny piece of mRNA but you want the whole organism reproducing in your body?  The whole genome and all the proteins made?</text></item></parent_chain></comment><story><title>Brain imaging before and after Covid-19 in UK Biobank</title><url>https://www.medrxiv.org/content/10.1101/2021.06.11.21258690v1</url></story>
<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>xwolfi</author><text>You&amp;#x27;re right in a way but I think these people are still a tad wrong. It&amp;#x27;s not that everyone deny there can be side effects, on pregnancy or otherwise. It&amp;#x27;s that if nobody does the sacrifice, and everybody has his little thing he wants to protect (you want to get pregnant, I want to keep on working, my wife wants to be there for our kid, our parents have diabetes, etc etc) then nobody gets the vaccine.&lt;p&gt;Get it, whatever it cost you, because it&amp;#x27;s your duty.</text><parent_chain><item><author>throwkeep</author><text>There are valid concerns and a difficult risk benefit analysis for some cohorts, I think. What are your thoughts on this? Put yourself in her shoes:&lt;p&gt;&amp;quot;I held off on a COVID vaccine because I wanted to wait for data with positive signals for both pregnancy in the short term and long-run fertility. I’m trying to get pregnant, and those are the two things I care about most.&lt;p&gt;Vaccine data is so politicized that it’s actually somewhat difficult to find full studies, results discussions or data sets as a layman, because every search term redirects you to “yes, get vaccinated right now, your concerns are merely ignorance”&lt;p&gt;The other study that concerns me shows that the vaccine’s lipid nanoparticles— which carry the RNA instructions for the spike protein — move beyond the deltoid muscle they’re injected into and accumulate in other tissues, and seem to accumulate in ovarian tissue preferentially.&lt;p&gt;That study looked at a &lt;i&gt;very&lt;/i&gt; small sample, but given what we &lt;i&gt;think&lt;/i&gt; we know about the spike protein — it likely causes some degree of tissue damage on its own, independent of the virus — it’s something that definitely demands further study&lt;p&gt;Anyway, I feel like I need to come clean at this point. For a long time I was avoiding the vaccine because I wanted to hold out for more data. Now I’m actively choosing not to get it because what I’ve seen is providing the opposite of a positive safety signal for my purposes.&lt;p&gt;It’s &lt;i&gt;really&lt;/i&gt; important that I clarify I’m not at a high risk of exposure. I generally don’t work or even socialize outside my home. Lockdown life frankly doesn’t look that different from my preferred lifestyle. If I were a high exposure risk I would think about this differently&lt;p&gt;I’m in the process of getting a prescription for prophylactic ivermectin, which has also become extremely politicized — to the point of becoming a censored topic on some platforms. I’m not giving advice, here. I’m not making broader efficacy claims. I’m just trying to be honest&lt;p&gt;COVID is no joke. You do not want to get COVID. “Long COVID” symptoms should concern you even if you don’t think an infection would kill you. But the vaccines are very new and skipped a great deal of otherwise required safety testing, and some of this data is really worrisome.&amp;quot;&lt;p&gt;&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;mobile.twitter.com&amp;#x2F;webdevMason&amp;#x2F;status&amp;#x2F;1405649896212819975&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;mobile.twitter.com&amp;#x2F;webdevMason&amp;#x2F;status&amp;#x2F;14056498962128...&lt;/a&gt;</text></item><item><author>JohnJamesRambo</author><text>I wish I could get people that are avoiding the COVID vaccine “because we don’t know what the long term effects are” to realize that we have real data showing that there are long term effects from getting full blown COVID.  You don’t want a tiny piece of mRNA but you want the whole organism reproducing in your body?  The whole genome and all the proteins made?</text></item></parent_chain></comment><story><title>Brain imaging before and after Covid-19 in UK Biobank</title><url>https://www.medrxiv.org/content/10.1101/2021.06.11.21258690v1</url></story>