<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>andreareina</author><text>It’s a half right sort of thing. Overdose is acutely toxic to the liver. Dosage guidelines are safe unless you’ have impaired liver function (been drinking?), &lt;i&gt;or&lt;/i&gt; you’re taking another drug that also has paracetamol (e.g. combo paracetamol&amp;#x2F;ibuprofen, painkillers for period cramps, etc). I’ve seen opiates compounded with paracetamol and I wouldn’t be surprised if it’s mostly to (try to) limit abuse.&lt;p&gt;Then again this is in contrast to NSAIDs like ibuprofen that can result in gastric bleeding even at the recommended dose.&lt;p&gt;I prefer paracetamol&amp;#x2F;acetaminophen for most uses but I’m pretty careful about how much and what else I’m taking.</text><parent_chain><item><author>SargeDebian</author><text>Do you have a source for that? It is the default painkiller in the Netherlands, and it&amp;#x27;s what GPs typically prescribe people that come to them with something that doesn&amp;#x27;t really need treatment, to the point that it&amp;#x27;s a meme.&lt;p&gt;I&amp;#x27;d be interested in hearing how they&amp;#x27;re wrong to that extent, on such scale.</text></item><item><author>midoridensha</author><text>[flagged]</text></item><item><author>jiggawatts</author><text>Reminds me of a conversation I had with someone in the pharmaceutical industry. He lamented that the box was by far the most expensive component for many of their products. Paracetamol is &lt;i&gt;cheap&lt;/i&gt;, glossy full-colour printing with embossing is not!</text></item></parent_chain></comment><story><title>No, you can’t manufacture that like Apple does (2014)</title><url>https://beneinstein.medium.com/no-you-cant-manufacture-that-like-apple-does-93bea02a3bbf</url></story>
<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>davidkuennen</author><text>Interesting. Anecdotally we (myself, friends and family) never get prescribed Paracetamol here in Germany. It&amp;#x27;s always Ibuprofen. I always felt it was obvious, given the supposedly side effects of it.</text><parent_chain><item><author>SargeDebian</author><text>Do you have a source for that? It is the default painkiller in the Netherlands, and it&amp;#x27;s what GPs typically prescribe people that come to them with something that doesn&amp;#x27;t really need treatment, to the point that it&amp;#x27;s a meme.&lt;p&gt;I&amp;#x27;d be interested in hearing how they&amp;#x27;re wrong to that extent, on such scale.</text></item><item><author>midoridensha</author><text>[flagged]</text></item><item><author>jiggawatts</author><text>Reminds me of a conversation I had with someone in the pharmaceutical industry. He lamented that the box was by far the most expensive component for many of their products. Paracetamol is &lt;i&gt;cheap&lt;/i&gt;, glossy full-colour printing with embossing is not!</text></item></parent_chain></comment><story><title>No, you can’t manufacture that like Apple does (2014)</title><url>https://beneinstein.medium.com/no-you-cant-manufacture-that-like-apple-does-93bea02a3bbf</url></story>