<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>colechristensen</author><text>There are negative side effects from consuming the mushrooms which you don&amp;#x27;t get from purified psilocybin.&lt;p&gt;Dosage is important. There isn&amp;#x27;t a way to test for potency which would ensure a reliable dose.&lt;p&gt;Argument fallacies:&lt;p&gt;* your anecdotal positive experiences&lt;p&gt;* suggesting superiority because something is &amp;quot;from nature&amp;quot;&lt;p&gt;* referring to &amp;quot;mistakes from the past&amp;quot; without naming any&lt;p&gt;* suggesting superiority that &amp;quot;has been (done) for thousands of years&amp;quot;&lt;p&gt;Think about why these kinds of arguments are made on different topics which you disagree with and then rethink why you are making them here.</text><parent_chain><item><author>mikeg8</author><text>&amp;gt; &amp;quot;It&amp;#x27;s unfeasible and way too expensive to extract psilocybin from magic mushrooms and the best chemical synthesis methods require expensive and difficult to source starting substrates...”&lt;p&gt;This is one of those situations where I feel like we (humans) are approaching it all wrong. Why over complicate it by trying to “extract” the psilocybin instead of treating it like marijuana and growing the mushrooms in highly controlled settings and then testing for potency?!&lt;p&gt;As someone who’s recently had very positive experiences with both large&amp;#x2F;small doses of magic mushrooms, it’s disheartening to see us remake the mistakes of the past by trying to over-engineer something from nature. IMO, the optimum approach would be to have humility and simply be stewards of this wonderful gift. There is no reason That psilocybin shouldn’t be administered in its most common form, as it has been for thousands of years, other than it would be harder to profit off of.</text></item></parent_chain></comment><story><title>Psilocybin Produced in Yeast</title><url>https://phys.org/news/2020-04-psychedelic-compound-magic-mushrooms-yeast.html</url></story>
<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>arpa</author><text>Hey, drug on wars still exists in the world. You can get excessive jail time just for having some (regardless of quantity) marijuana on you - and that is in &amp;quot;western&amp;quot; country. It was not so long ago that &amp;quot;marijuana had no possible medical application&amp;quot; and was scheduled as a class A drug in UK (and I think, still is). There is a lot of stigma, and decades of bad science, propaganda, and manufactured hatred run deep. Research is difficult, if at all possible because excessively harsh legislation. And who benefits?.. criminal cartels and enforcement agencies. This is also why scientists go such extreme lengths to create psychoactive mimics (&amp;quot;legal highs&amp;quot;) - so they can research the stuff that is at least similar without going to jail. It&amp;#x27;s a fucked up world, my friend.&lt;p&gt;It&amp;#x27;s not the scientists&amp;#x27; approach that is wrong, it&amp;#x27;s the legislators...</text><parent_chain><item><author>mikeg8</author><text>&amp;gt; &amp;quot;It&amp;#x27;s unfeasible and way too expensive to extract psilocybin from magic mushrooms and the best chemical synthesis methods require expensive and difficult to source starting substrates...”&lt;p&gt;This is one of those situations where I feel like we (humans) are approaching it all wrong. Why over complicate it by trying to “extract” the psilocybin instead of treating it like marijuana and growing the mushrooms in highly controlled settings and then testing for potency?!&lt;p&gt;As someone who’s recently had very positive experiences with both large&amp;#x2F;small doses of magic mushrooms, it’s disheartening to see us remake the mistakes of the past by trying to over-engineer something from nature. IMO, the optimum approach would be to have humility and simply be stewards of this wonderful gift. There is no reason That psilocybin shouldn’t be administered in its most common form, as it has been for thousands of years, other than it would be harder to profit off of.</text></item></parent_chain></comment><story><title>Psilocybin Produced in Yeast</title><url>https://phys.org/news/2020-04-psychedelic-compound-magic-mushrooms-yeast.html</url></story>