<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>rossdavidh</author><text>From the last link: &amp;quot;Conclusions: This study demonstrated that natural immunity confers longer lasting and stronger protection against infection, symptomatic disease and hospitalization caused by the Delta variant of SARS-CoV-2, compared to the BNT162b2 two-dose vaccine-induced immunity. Individuals who were both previously infected with SARS-CoV-2 and given a single dose of the vaccine gained additional protection against the Delta variant.&amp;quot;&lt;p&gt;Note the &amp;quot;longer lasting and stronger&amp;quot;.</text><parent_chain><item><author>oldgradstudent</author><text>&amp;gt; However, vaccines only target spike protein, while a previous infection will cause your body to produce antibodies for a much larger set of targets on the virus, which in practice leads to a more robust immunity. This is supported by data from Israel and some recent studies&lt;p&gt;No, it does not.&lt;p&gt;The data from Israel only supports the claim that immunity from infection is longer lasting than from the vaccine, which should not have been a surprise to anyone.&lt;p&gt;It does not support any specific mechanistic explanation.</text></item><item><author>bananabiscuit</author><text>The spike protein targeting antibodies produced by the vaccine do indeed target a wider range of spike mutations than the spike protein antibodies from previous infection. However, vaccines only target spike protein, while a previous infection will cause your body to produce antibodies for a much larger set of targets on the virus, which in practice leads to a more robust immunity. This is supported by data from Israel and some recent studies.&lt;p&gt;&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.israelnationalnews.com&amp;#x2F;News&amp;#x2F;News.aspx&amp;#x2F;309762&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.israelnationalnews.com&amp;#x2F;News&amp;#x2F;News.aspx&amp;#x2F;309762&lt;/a&gt;&lt;p&gt;&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.israelnationalnews.com&amp;#x2F;News&amp;#x2F;News.aspx&amp;#x2F;310963&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.israelnationalnews.com&amp;#x2F;News&amp;#x2F;News.aspx&amp;#x2F;310963&lt;/a&gt;&lt;p&gt;&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.medrxiv.org&amp;#x2F;content&amp;#x2F;10.1101&amp;#x2F;2021.08.24.21262415v1&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.medrxiv.org&amp;#x2F;content&amp;#x2F;10.1101&amp;#x2F;2021.08.24.21262415v...&lt;/a&gt;</text></item></parent_chain></comment><story><title>Immunity Generated from Covid-19 Vaccines Differs from an Infection</title><url>https://directorsblog.nih.gov/2021/06/22/how-immunity-generated-from-covid-19-vaccines-differs-from-an-infection/</url></story>
<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>lamontcg</author><text>Honestly I have yet to see any convincing scientific evidence that is free from confounding factors which suggests that there is waning immunity.&lt;p&gt;And there&amp;#x27;s reason to believe from HCoV-229E that immunity against coronaviruses is actually durable and that reinfection is due to mutation and immune escape.&lt;p&gt;&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;journals.plos.org&amp;#x2F;plospathogens&amp;#x2F;article?id=10.1371&amp;#x2F;journal.ppat.1009453&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;journals.plos.org&amp;#x2F;plospathogens&amp;#x2F;article?id=10.1371&amp;#x2F;j...&lt;/a&gt;</text><parent_chain><item><author>oldgradstudent</author><text>&amp;gt; However, vaccines only target spike protein, while a previous infection will cause your body to produce antibodies for a much larger set of targets on the virus, which in practice leads to a more robust immunity. This is supported by data from Israel and some recent studies&lt;p&gt;No, it does not.&lt;p&gt;The data from Israel only supports the claim that immunity from infection is longer lasting than from the vaccine, which should not have been a surprise to anyone.&lt;p&gt;It does not support any specific mechanistic explanation.</text></item><item><author>bananabiscuit</author><text>The spike protein targeting antibodies produced by the vaccine do indeed target a wider range of spike mutations than the spike protein antibodies from previous infection. However, vaccines only target spike protein, while a previous infection will cause your body to produce antibodies for a much larger set of targets on the virus, which in practice leads to a more robust immunity. This is supported by data from Israel and some recent studies.&lt;p&gt;&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.israelnationalnews.com&amp;#x2F;News&amp;#x2F;News.aspx&amp;#x2F;309762&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.israelnationalnews.com&amp;#x2F;News&amp;#x2F;News.aspx&amp;#x2F;309762&lt;/a&gt;&lt;p&gt;&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.israelnationalnews.com&amp;#x2F;News&amp;#x2F;News.aspx&amp;#x2F;310963&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.israelnationalnews.com&amp;#x2F;News&amp;#x2F;News.aspx&amp;#x2F;310963&lt;/a&gt;&lt;p&gt;&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.medrxiv.org&amp;#x2F;content&amp;#x2F;10.1101&amp;#x2F;2021.08.24.21262415v1&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.medrxiv.org&amp;#x2F;content&amp;#x2F;10.1101&amp;#x2F;2021.08.24.21262415v...&lt;/a&gt;</text></item></parent_chain></comment><story><title>Immunity Generated from Covid-19 Vaccines Differs from an Infection</title><url>https://directorsblog.nih.gov/2021/06/22/how-immunity-generated-from-covid-19-vaccines-differs-from-an-infection/</url></story>