<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>heymijo</author><text>I suggest reading the current wisdom from Dr. Les Dethlefson, human microbiota researcher at Stanford&amp;#x27;s Relman lab [0].&lt;p&gt;In the link he addresses the difference between addressing an acute condition with probiotics versus long-term maintenance of health. Your question seems to land somewhere in the middle. So see what he has to say and please remember, this is far from settled science!&lt;p&gt;[0] &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;humanmicrobiota.weebly.com&amp;#x2F;prebiotics--probiotics.html&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;humanmicrobiota.weebly.com&amp;#x2F;prebiotics--probiotics.ht...&lt;/a&gt;</text><parent_chain><item><author>Semirhage</author><text>What I want to know is what to do about it by way of probiotic therapy or buffering agents and such. Efficacy of probiotics in practice seems mixed, so what exactly is the takeaway here for the practically minded person who sometimes takes anti-inflammatory medications?</text></item></parent_chain></comment><story><title>Gut microbes are vulnerable to wide range of drugs</title><url>https://www.nature.com/articles/d41586-018-02780-x</url></story>
<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>forgotmypw</author><text>I think that the best thing one can do for their microbiome is to stop trying to kill germs in everything around us. Also, when a dog wants to kiss you, accept it. They are good at maintaining theirs.&lt;p&gt;Look at the ingredients on all the products you use. Unless it&amp;#x27;s Dr. Bronner&amp;#x27;s soap or something similar, chances it&amp;#x27;s harmful to both humans and microbes. Just stop using and stop buying that shit!&lt;p&gt;Sterility is good for the operating table, but not for everyday life.</text><parent_chain><item><author>Semirhage</author><text>What I want to know is what to do about it by way of probiotic therapy or buffering agents and such. Efficacy of probiotics in practice seems mixed, so what exactly is the takeaway here for the practically minded person who sometimes takes anti-inflammatory medications?</text></item></parent_chain></comment><story><title>Gut microbes are vulnerable to wide range of drugs</title><url>https://www.nature.com/articles/d41586-018-02780-x</url></story>