<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>culi</author><text>I think a very interesting field of inquiry into oral microbiota is a broad evolutionary approach. There was a study published in Nature Genetics[0] showing big changes in oral microbiota corresponding with Neolithic and Industrial dietary change. Modern oral microbiota are markedly less diverse than historic populations and the, much more developed, study of the gut microbiome shows us that very microbial diversity very often corresponds with usually-commensal microbes becoming pathogenic. It seems that cariogenic bacteria became dominant, apparently during the Industrial Revolution.[0] But we know that pre-Neolithic hominins very rarely had caries.[1] Despite affecting anywhere between 60-90% of schoolchildren in industrialized nations, less than 3% of P. robustus specimens examined had dental caries.[1]&lt;p&gt;What&amp;#x27;s MOST fascinating to me is that this dance isn&amp;#x27;t just our mouths vs the microbiomes. There&amp;#x27;s now considerable evidence that it is more likely to be the host response to the bacteria that leads to the tissue changes noted in gingivitis and periodontitis[2]&lt;p&gt;[0] &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC3996550&amp;#x2F;&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC3996550&amp;#x2F;&lt;/a&gt;&lt;p&gt;[1] &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.sciencedirect.com&amp;#x2F;science&amp;#x2F;article&amp;#x2F;abs&amp;#x2F;pii&amp;#x2F;000399699090185D?via%3Dihub&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.sciencedirect.com&amp;#x2F;science&amp;#x2F;article&amp;#x2F;abs&amp;#x2F;pii&amp;#x2F;000399...&lt;/a&gt;&lt;p&gt;[2] &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC3692012&amp;#x2F;&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC3692012&amp;#x2F;&lt;/a&gt;</text><parent_chain><item><author>bmau5</author><text>The evolutionary adaptations oral bacteria have developed to coexist are fascinating. Another example is the known gum disease-causing species, P. gingivalis, can suppress our adaptive immunity [1].&lt;p&gt;This finding underscores the importance of taking preventative approaches to prevent attachment of biofilm producers (and why daily hygiene is so important), and finding more approaches to biofilm destabilization, like incorporating arginine into diets and possibly oral care products [2].&lt;p&gt;Source: founder of an oral microbiome testing company [3].&lt;p&gt;[1] &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC5122233&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC5122233&lt;/a&gt;&lt;p&gt;[2] &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;journals.plos.org&amp;#x2F;plosone&amp;#x2F;article?id=10.1371&amp;#x2F;journal.pone.0121835&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;journals.plos.org&amp;#x2F;plosone&amp;#x2F;article?id=10.1371&amp;#x2F;journal...&lt;/a&gt;&lt;p&gt;[3] &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.bristlehealth.com&amp;#x2F;&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.bristlehealth.com&amp;#x2F;&lt;/a&gt;</text></item></parent_chain></comment><story><title>Microbes that cause cavities can form superorganisms able to ‘crawl’</title><url>https://penntoday.upenn.edu/news/microbes-cause-cavities-can-form-superorganisms-able-crawl-and-spread-teeth</url></story>
<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>thelittleone</author><text>A fascinating field of inquiry. Digestive systems and their inhabitants have evolved over millions of years.&lt;p&gt;I recently shifted my mindset to feed not just for me, but also for the ~2kg of microbiota [1] inhabiting my digestive system. Has been great for my health.&lt;p&gt;[1] &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.racgp.org.au&amp;#x2F;afp&amp;#x2F;2017&amp;#x2F;april&amp;#x2F;the-gut-microbiome&amp;#x2F;&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.racgp.org.au&amp;#x2F;afp&amp;#x2F;2017&amp;#x2F;april&amp;#x2F;the-gut-microbiome&amp;#x2F;&lt;/a&gt;</text><parent_chain><item><author>bmau5</author><text>The evolutionary adaptations oral bacteria have developed to coexist are fascinating. Another example is the known gum disease-causing species, P. gingivalis, can suppress our adaptive immunity [1].&lt;p&gt;This finding underscores the importance of taking preventative approaches to prevent attachment of biofilm producers (and why daily hygiene is so important), and finding more approaches to biofilm destabilization, like incorporating arginine into diets and possibly oral care products [2].&lt;p&gt;Source: founder of an oral microbiome testing company [3].&lt;p&gt;[1] &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC5122233&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC5122233&lt;/a&gt;&lt;p&gt;[2] &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;journals.plos.org&amp;#x2F;plosone&amp;#x2F;article?id=10.1371&amp;#x2F;journal.pone.0121835&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;journals.plos.org&amp;#x2F;plosone&amp;#x2F;article?id=10.1371&amp;#x2F;journal...&lt;/a&gt;&lt;p&gt;[3] &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.bristlehealth.com&amp;#x2F;&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.bristlehealth.com&amp;#x2F;&lt;/a&gt;</text></item></parent_chain></comment><story><title>Microbes that cause cavities can form superorganisms able to ‘crawl’</title><url>https://penntoday.upenn.edu/news/microbes-cause-cavities-can-form-superorganisms-able-crawl-and-spread-teeth</url></story>