<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>GolfPopper</author><text>Sucralose and aspartame are both reliable migraine triggers for me, and have been at least since my early 20s. Stevia and monkfruit are fine. The only other even semi-consistent migraine trigger for me is alcohol.&lt;p&gt;I&amp;#x27;ve successfully avoided migraines for years by carefully avoiding sucralose and aspartame (and drinking little to no alcohol), but even a small serving of something &amp;quot;sugar-free&amp;quot; and within a few hours I&amp;#x27;ll get a crippling migraine. In college, I spent a while testing, and the link between both sucralose and aspartame and my migraines was perfectly reliable.&lt;p&gt;Alcohol in general has been harder to nail down. A single beer won&amp;#x27;t normally trigger a migraine, while sometimes a single glass of wine or small cocktail will. If I drank to excess it was hard to tell the difference between a hangover and a migraine; I wasn&amp;#x27;t that invested in social alcohol consumption, so I&amp;#x27;ve mostly just been a teetotaler since college. Absinthe uniquely reliably gives me an acephalgic migraine with aura around 12 hours after drinking.&lt;p&gt;Edited to add: I&amp;#x27;ve just stayed away from ace-K and sugar-alcohols as a precaution. I&amp;#x27;m past the point in my life where I have any real interest in risking crippling migraines for the sake of personal curiosity.</text><parent_chain></parent_chain></comment><story><title>Too much serendipity</title><url>https://www.lesswrong.com/posts/oA23zoEjPnzqfHiCt/there-is-way-too-much-serendipity</url></story>
<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>johngossman</author><text>I recently learned that anesthesia is the same. Not only has no anesthesia ever been developed except through &amp;quot;serendipity.&amp;quot; Not only that, but anesthesia that works for humans also effect a wide range of things including plants and bacteria. But why is an active area of research. There are even speculations that there may be quantum effects involved. Biology and chemistry are insanely complex.</text><parent_chain></parent_chain></comment><story><title>Too much serendipity</title><url>https://www.lesswrong.com/posts/oA23zoEjPnzqfHiCt/there-is-way-too-much-serendipity</url></story>