<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>skosuri</author><text>Our lab is working on ways to screen large libraries of designed proteins for engineered orthogonally interacting libraries. The thought would this would be a start of a modular resuasable library for molecular self-assembly.  If you are interested, we&amp;#x27;re definitely hiring!</text><parent_chain><item><author>kanzure</author><text>One of the startups that fizzled out was Nanorex, which is where Nanoengineer was made. Thankfully they were open to releasing the source code and version control repository when they decided to shutdown. The results of that are here: &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;github.com&amp;#x2F;kanzure&amp;#x2F;nanoengineer&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;github.com&amp;#x2F;kanzure&amp;#x2F;nanoengineer&lt;/a&gt;&lt;p&gt;I think everyone is stuck wondering how to make the tooltips from the tooltips paper: &lt;a href=&quot;http:&amp;#x2F;&amp;#x2F;diyhpl.us&amp;#x2F;~bryan&amp;#x2F;papers2&amp;#x2F;nanotech&amp;#x2F;Optimal%20tooltip%20trajectories%20in%20a%20hydrogen%20abstraction%20tool%20recharge%20reaction%20sequence%20for%20positionally%20controlled%20diamond%20mechanosynthesis.pdf&quot; rel=&quot;nofollow&quot;&gt;http:&amp;#x2F;&amp;#x2F;diyhpl.us&amp;#x2F;~bryan&amp;#x2F;papers2&amp;#x2F;nanotech&amp;#x2F;Optimal%20tooltip%2...&lt;/a&gt;&lt;p&gt;All of that was motivated by goals of making nanofactories like shown in this eye candy video: &lt;a href=&quot;http:&amp;#x2F;&amp;#x2F;www.youtube.com&amp;#x2F;watch?v=vEYN18d7gHg&quot; rel=&quot;nofollow&quot;&gt;http:&amp;#x2F;&amp;#x2F;www.youtube.com&amp;#x2F;watch?v=vEYN18d7gHg&lt;/a&gt;&lt;p&gt;Because positional, precise molecular manufacturing still doesn&amp;#x27;t exist, I have been increasingly interested in using DNA synthesis (using phosphoramidite chemistry) to combinatorially build proteins that lock together in pre-defined shape based on ligand-specific binding affinities between the blocks. The Nanosystems book left out a lot of biology that can be hijacked to help out goals like these.&lt;p&gt;Long-term we might be able to coerce enzymes into creating molecular machines anyway: &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;groups.google.com&amp;#x2F;group&amp;#x2F;enzymaticsynthesis&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;groups.google.com&amp;#x2F;group&amp;#x2F;enzymaticsynthesis&lt;/a&gt;</text></item></parent_chain></comment><story><title>Nobody’s Talking About Nanotech Anymore</title><url>http://time.com/4068125/nanotech-sector/</url></story>
<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>adrianN</author><text>As I see it, proteins are our best bet of making custom nanomachines. They&amp;#x27;re proven to work. The hard part is understanding protein folding and predicting protein function from the amino acid sequence.</text><parent_chain><item><author>kanzure</author><text>One of the startups that fizzled out was Nanorex, which is where Nanoengineer was made. Thankfully they were open to releasing the source code and version control repository when they decided to shutdown. The results of that are here: &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;github.com&amp;#x2F;kanzure&amp;#x2F;nanoengineer&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;github.com&amp;#x2F;kanzure&amp;#x2F;nanoengineer&lt;/a&gt;&lt;p&gt;I think everyone is stuck wondering how to make the tooltips from the tooltips paper: &lt;a href=&quot;http:&amp;#x2F;&amp;#x2F;diyhpl.us&amp;#x2F;~bryan&amp;#x2F;papers2&amp;#x2F;nanotech&amp;#x2F;Optimal%20tooltip%20trajectories%20in%20a%20hydrogen%20abstraction%20tool%20recharge%20reaction%20sequence%20for%20positionally%20controlled%20diamond%20mechanosynthesis.pdf&quot; rel=&quot;nofollow&quot;&gt;http:&amp;#x2F;&amp;#x2F;diyhpl.us&amp;#x2F;~bryan&amp;#x2F;papers2&amp;#x2F;nanotech&amp;#x2F;Optimal%20tooltip%2...&lt;/a&gt;&lt;p&gt;All of that was motivated by goals of making nanofactories like shown in this eye candy video: &lt;a href=&quot;http:&amp;#x2F;&amp;#x2F;www.youtube.com&amp;#x2F;watch?v=vEYN18d7gHg&quot; rel=&quot;nofollow&quot;&gt;http:&amp;#x2F;&amp;#x2F;www.youtube.com&amp;#x2F;watch?v=vEYN18d7gHg&lt;/a&gt;&lt;p&gt;Because positional, precise molecular manufacturing still doesn&amp;#x27;t exist, I have been increasingly interested in using DNA synthesis (using phosphoramidite chemistry) to combinatorially build proteins that lock together in pre-defined shape based on ligand-specific binding affinities between the blocks. The Nanosystems book left out a lot of biology that can be hijacked to help out goals like these.&lt;p&gt;Long-term we might be able to coerce enzymes into creating molecular machines anyway: &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;groups.google.com&amp;#x2F;group&amp;#x2F;enzymaticsynthesis&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;groups.google.com&amp;#x2F;group&amp;#x2F;enzymaticsynthesis&lt;/a&gt;</text></item></parent_chain></comment><story><title>Nobody’s Talking About Nanotech Anymore</title><url>http://time.com/4068125/nanotech-sector/</url></story>