<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>base698</author><text>Most of the excess deaths are not covid but attributed from effects of lockdown (drug use, untreated cancers).</text><parent_chain><item><author>yojo</author><text>Excess deaths are widely considered to be “from Covid” right now. It is possible there’s something else going on, but as the parent said, the numbers you should care about when making a vaccine decision are the mortality rate of the vaccinated vs the unvaccinated.&lt;p&gt;Unvaccinated people are dying at a much higher rate. If your biggest concern is not dying, you should be vaccinated.</text></item><item><author>treeman79</author><text>Isn’t “unknown cause of death” skyrocketing?&lt;p&gt;&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;youtu.be&amp;#x2F;F74iqEJnb14&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;youtu.be&amp;#x2F;F74iqEJnb14&lt;/a&gt;&lt;p&gt;&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;thehill.com&amp;#x2F;changing-america&amp;#x2F;well-being&amp;#x2F;longevity&amp;#x2F;588738-huge-huge-numbers-death-rates-up-40-percent-over-pre&amp;#x2F;amp&amp;#x2F;&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;thehill.com&amp;#x2F;changing-america&amp;#x2F;well-being&amp;#x2F;longevity&amp;#x2F;58...&lt;/a&gt;</text></item><item><author>mabbo</author><text>But the thing is we ran a massive experiment on this called &amp;quot;The covid-19 pandemic&amp;quot;.&lt;p&gt;What we saw was no serious increase in mortality for the immunized, and a significant increase in mortality for the non-immunized.&lt;p&gt;Seems like the data from that experiment should be taken into consideration when deciding if the tradeoff is worthwhile, right?</text></item><item><author>lazyier</author><text>I donno.  Seems like white blood cells are kinda important.&lt;p&gt;We have a huge number of interactions with bacteria and viruses and all sorts of microorganisms. Hundreds? Thousands times a day?  Scratches in the kitchen while preparing food, for example, floods our body with stuff that white blood cells are required to deal with.&lt;p&gt;Giving up some of the ability to deal with those for a small reduction in the symptoms associated with a specific disease doesn&amp;#x27;t seem like a useful trade off.</text></item><item><author>mabbo</author><text>&amp;gt;  On the other hand, we report that after pre-exposure to mRNA-LNPs, the resistance of mice to heterologous infections with influenza virus increased while resistance to Candida albicans decreased.&lt;p&gt;It sounds to me as though the tradeoff being made here is: a slightly decreased immune response generally, but a better immune response to the thing you&amp;#x27;ve been immunized against. That seems to be a reasonable tradeoff if there&amp;#x27;s something really bad going around.&lt;p&gt;But as they say in the paper summary: more research is needed.&lt;p&gt;Also: this is purely in mice. They have zero data on whether this is true for humans.</text></item></parent_chain></comment><story><title>Pre-exposure to mRNA-LNP inhibits adaptive immune responses in mice</title><url>https://pubmed.ncbi.nlm.nih.gov/36054264/</url></story>
<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>code51</author><text>There are large crowds that took 2 doses in pandemic period (getting vaccinated properly back at the time) but not receiving boosters.&lt;p&gt;It would be easy to track:&lt;p&gt;- 2 dose, no other booster&lt;p&gt;- all boosters&lt;p&gt;- no vaccine&lt;p&gt;and readjust results considering age and other bias etc.&lt;p&gt;If all booster people have excess deaths, than &amp;quot;not from Covid&amp;quot; ?
If 2 dose people excess deaths &amp;lt; all boosted people, than something about vaccine?
No vaccine could be control.</text><parent_chain><item><author>yojo</author><text>Excess deaths are widely considered to be “from Covid” right now. It is possible there’s something else going on, but as the parent said, the numbers you should care about when making a vaccine decision are the mortality rate of the vaccinated vs the unvaccinated.&lt;p&gt;Unvaccinated people are dying at a much higher rate. If your biggest concern is not dying, you should be vaccinated.</text></item><item><author>treeman79</author><text>Isn’t “unknown cause of death” skyrocketing?&lt;p&gt;&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;youtu.be&amp;#x2F;F74iqEJnb14&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;youtu.be&amp;#x2F;F74iqEJnb14&lt;/a&gt;&lt;p&gt;&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;thehill.com&amp;#x2F;changing-america&amp;#x2F;well-being&amp;#x2F;longevity&amp;#x2F;588738-huge-huge-numbers-death-rates-up-40-percent-over-pre&amp;#x2F;amp&amp;#x2F;&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;thehill.com&amp;#x2F;changing-america&amp;#x2F;well-being&amp;#x2F;longevity&amp;#x2F;58...&lt;/a&gt;</text></item><item><author>mabbo</author><text>But the thing is we ran a massive experiment on this called &amp;quot;The covid-19 pandemic&amp;quot;.&lt;p&gt;What we saw was no serious increase in mortality for the immunized, and a significant increase in mortality for the non-immunized.&lt;p&gt;Seems like the data from that experiment should be taken into consideration when deciding if the tradeoff is worthwhile, right?</text></item><item><author>lazyier</author><text>I donno.  Seems like white blood cells are kinda important.&lt;p&gt;We have a huge number of interactions with bacteria and viruses and all sorts of microorganisms. Hundreds? Thousands times a day?  Scratches in the kitchen while preparing food, for example, floods our body with stuff that white blood cells are required to deal with.&lt;p&gt;Giving up some of the ability to deal with those for a small reduction in the symptoms associated with a specific disease doesn&amp;#x27;t seem like a useful trade off.</text></item><item><author>mabbo</author><text>&amp;gt;  On the other hand, we report that after pre-exposure to mRNA-LNPs, the resistance of mice to heterologous infections with influenza virus increased while resistance to Candida albicans decreased.&lt;p&gt;It sounds to me as though the tradeoff being made here is: a slightly decreased immune response generally, but a better immune response to the thing you&amp;#x27;ve been immunized against. That seems to be a reasonable tradeoff if there&amp;#x27;s something really bad going around.&lt;p&gt;But as they say in the paper summary: more research is needed.&lt;p&gt;Also: this is purely in mice. They have zero data on whether this is true for humans.</text></item></parent_chain></comment><story><title>Pre-exposure to mRNA-LNP inhibits adaptive immune responses in mice</title><url>https://pubmed.ncbi.nlm.nih.gov/36054264/</url></story>