<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>seesawtron</author><text>A controversial topic .. there is an effect called mito-hormesis .. when you do excercise there are small amount of free radicals leaked that activates kinases and inhibits phosphatades and overall increase phosphorylation in the cell. Through this and other pathways, some genes are expressed which are supposed to increase survival, so overall there is a window of free raficals concentration. If you get below it (total blockade) you will prevent the hormesis (beneficial) effect, but if you get above it, you can get all the free radical related diseases e.g neurodegenerative diseases.&lt;p&gt;[0] &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;doi.org&amp;#x2F;10.1038&amp;#x2F;nm.3624&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;doi.org&amp;#x2F;10.1038&amp;#x2F;nm.3624&lt;/a&gt;</text><parent_chain></parent_chain></comment><story><title>Antioxidants prevent health-promoting effects of physical exercise (2009) [pdf]</title><url>https://www.pnas.org/content/pnas/106/21/8665.full.pdf</url></story>
<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>ketamine__</author><text>&amp;gt; Taken together, these previously published findings tentatively suggest that fruits and vegetables may exert health-promoting effects
despite their antioxidant content and possibly due to other bio-active compounds. However, it should be noted that the current study applied comparably high doses of oral antioxidants, which have been tested in healthy young men only.</text><parent_chain></parent_chain></comment><story><title>Antioxidants prevent health-promoting effects of physical exercise (2009) [pdf]</title><url>https://www.pnas.org/content/pnas/106/21/8665.full.pdf</url></story>