<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>dumbneurologist</author><text>I am a neurologist. this is actually the exact opposite of what you &lt;i&gt;should&lt;/i&gt; care about, which is &amp;quot;does it work to treat ___&amp;quot;&lt;p&gt;In this trial, and 99% of other trials, there is no mechanism provided by the study, only a measurement of causality (which is the same thing as effectiveness).&lt;p&gt;The authors may think they know based on other, prior, basic science research (as they are postulating here), but it does not affect the conclusions of the trial ( whether they do or don&amp;#x27;t (or even if they are wrong).&lt;p&gt;Obviously it&amp;#x27;s intellectually satisfying to understand WHY, but it&amp;#x27;s not as important as &amp;quot;is it true?&amp;quot;</text><parent_chain><item><author>mrguyorama</author><text>&amp;gt;Because curcumin&amp;#x27;s anti-inflammatory properties may protect the brain from neurodegeneration&lt;p&gt;My very first question was: Please provide a possible physiological pathway for this. I&amp;#x27;m so glad it was answered in the very first sentence. So many of these &amp;quot;Superfood does X&amp;quot; studies are just trials with 10 people over a month, with no explanation as to __how__ it could possibly happen. It significantly increases the skepticism I have whenever something like this comes up&lt;p&gt;I also did not know Turmeric had anti-inflammatory properties. I guess I have reading to do.&lt;p&gt;Also interesting that they used (what seems to be) a name brand supplement instead of Turmeric</text></item></parent_chain></comment><story><title>Curry spice turmeric boosts memory by nearly 30%, eases depression, study finds</title><url>https://ac.els-cdn.com/S1064748117305110/1-s2.0-S1064748117305110-main.pdf?_tid=55b0e2e0-013c-11e8-b35b-00000aab0f01&amp;acdnat=1516822117_7ded3d2cd7f5c27fedf6a8992e549857</url></story>
<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>sp332</author><text>Here&amp;#x27;s a little more detail &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;news.uci.edu&amp;#x2F;2014&amp;#x2F;09&amp;#x2F;10&amp;#x2F;brain-inflammation-dramatically-disrupts-memory-retrieval-networks-uci-study-finds&amp;#x2F;&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;news.uci.edu&amp;#x2F;2014&amp;#x2F;09&amp;#x2F;10&amp;#x2F;brain-inflammation-dramatica...&lt;/a&gt; and a lot more detail &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;experts.illinois.edu&amp;#x2F;en&amp;#x2F;publications&amp;#x2F;interleukin-6-facilitates-lipopolysaccharide-induced-disruption-i&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;experts.illinois.edu&amp;#x2F;en&amp;#x2F;publications&amp;#x2F;interleukin-6-f...&lt;/a&gt;</text><parent_chain><item><author>mrguyorama</author><text>&amp;gt;Because curcumin&amp;#x27;s anti-inflammatory properties may protect the brain from neurodegeneration&lt;p&gt;My very first question was: Please provide a possible physiological pathway for this. I&amp;#x27;m so glad it was answered in the very first sentence. So many of these &amp;quot;Superfood does X&amp;quot; studies are just trials with 10 people over a month, with no explanation as to __how__ it could possibly happen. It significantly increases the skepticism I have whenever something like this comes up&lt;p&gt;I also did not know Turmeric had anti-inflammatory properties. I guess I have reading to do.&lt;p&gt;Also interesting that they used (what seems to be) a name brand supplement instead of Turmeric</text></item></parent_chain></comment><story><title>Curry spice turmeric boosts memory by nearly 30%, eases depression, study finds</title><url>https://ac.els-cdn.com/S1064748117305110/1-s2.0-S1064748117305110-main.pdf?_tid=55b0e2e0-013c-11e8-b35b-00000aab0f01&amp;acdnat=1516822117_7ded3d2cd7f5c27fedf6a8992e549857</url></story>