<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>dougmwne</author><text>The spike protein &amp;quot;springs&amp;quot; into an elongated configuration to help it latch onto a cell wall. Several of the vaccines have purposefully modified the protein used in the vaccine to keep it in it&amp;#x27;s unsprung form. The idea is that you want the antibody response to be focused on the unsprung protein so that you can prevent it from attaching and springing in the first place. From what I understand, the vaccine researchers have tested several variations of the spike protein in animal models to try to select one that will yield the best antibodies. The immune system is quite complex, but in theory it would be possible to design a protein that resulted in better antibodies than a wild infection. An analogy is it&amp;#x27;s like showing your immune system a lock and asking it to come up with a key that opens the lock. A different lock might produce a universal key that opens many locks.</text><parent_chain><item><author>anonymouse008</author><text>My intuitive and 0-observation question is how in the world can a reduced function protein give you a better immune response than the full-featured, infect anywhere there&amp;#x27;s an ACE receptor, c19 infection?&lt;p&gt;(&amp;#x27;A Request for Submissions&amp;#x27; I guess should be the title of this question)</text></item><item><author>glofish</author><text>Notable commentary:&lt;p&gt;&amp;gt; The findings of the authors suggest that infection and the development of an antibody response provides protection similar to or even better than currently used SARS-CoV-2 vaccines.&lt;p&gt;&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.thelancet.com&amp;#x2F;journals&amp;#x2F;lancet&amp;#x2F;article&amp;#x2F;PIIS0140-6736(21)00782-0&amp;#x2F;fulltext&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.thelancet.com&amp;#x2F;journals&amp;#x2F;lancet&amp;#x2F;article&amp;#x2F;PIIS0140-6...&lt;/a&gt;&lt;p&gt;In case you wanted to know - several hypotheses float around on what provides more protection an actual infection or the vaccine.</text></item></parent_chain></comment><story><title>Previous Covid-19 may cut risk of reinfection 84%</title><url>https://www.cidrap.umn.edu/news-perspective/2021/04/previous-covid-19-may-cut-risk-reinfection-84</url></story>
<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>sparker72678</author><text>Total load, and immune stimulation can be different between infection and vaccine, as unintuitive as that might be.&lt;p&gt;And many viruses, SARS-Cov-2 included, have immune response suppression effects that the vaccine does not.&lt;p&gt;More study is needed, both those are possibilities.</text><parent_chain><item><author>anonymouse008</author><text>My intuitive and 0-observation question is how in the world can a reduced function protein give you a better immune response than the full-featured, infect anywhere there&amp;#x27;s an ACE receptor, c19 infection?&lt;p&gt;(&amp;#x27;A Request for Submissions&amp;#x27; I guess should be the title of this question)</text></item><item><author>glofish</author><text>Notable commentary:&lt;p&gt;&amp;gt; The findings of the authors suggest that infection and the development of an antibody response provides protection similar to or even better than currently used SARS-CoV-2 vaccines.&lt;p&gt;&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.thelancet.com&amp;#x2F;journals&amp;#x2F;lancet&amp;#x2F;article&amp;#x2F;PIIS0140-6736(21)00782-0&amp;#x2F;fulltext&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.thelancet.com&amp;#x2F;journals&amp;#x2F;lancet&amp;#x2F;article&amp;#x2F;PIIS0140-6...&lt;/a&gt;&lt;p&gt;In case you wanted to know - several hypotheses float around on what provides more protection an actual infection or the vaccine.</text></item></parent_chain></comment><story><title>Previous Covid-19 may cut risk of reinfection 84%</title><url>https://www.cidrap.umn.edu/news-perspective/2021/04/previous-covid-19-may-cut-risk-reinfection-84</url></story>