<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>dr_coffee</author><text>The cell&amp;#x27;s ability to mechanically sense it&amp;#x27;s surroundings is fascinating. There is an old paper from 2006 in Cell that was similar to this study in that it showed onencould direct stem cell differentiation down different lineages purely by growing the cells on different stiffness substrates. Definitely worth a read of you are interested in this topic:&lt;p&gt;&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;m&amp;#x2F;pubmed&amp;#x2F;16923388&amp;#x2F;&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;m&amp;#x2F;pubmed&amp;#x2F;16923388&amp;#x2F;&lt;/a&gt;</text><parent_chain></parent_chain></comment><story><title>Scientists reverse aging process in rat brain stem cells</title><url>https://medicalxpress.com/news/2019-08-scientists-reverse-aging-rat-brain.html</url></story>
<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>ilaksh</author><text>Did they reverse the aging process, or just trick the cells into thinking they were in a less stiff environment?&lt;p&gt;Does disabling Piezo1 have any side effects?  I am guessing there is a reason for it.  Might be more applicable in severe MS than aging.</text><parent_chain></parent_chain></comment><story><title>Scientists reverse aging process in rat brain stem cells</title><url>https://medicalxpress.com/news/2019-08-scientists-reverse-aging-rat-brain.html</url></story>