<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>dimask</author><text>&amp;gt; we don&amp;#x27;t see spouses getting PD or AD often&lt;p&gt;Actually it may seem so [1], though still there is not any conclusive evidence to support a transmission hypothesis really as all this could be due to increased stress and such factors. Also, brain surgeons&amp;#x27; increased risk of AD and more reports of associated risks with regard to contamination from brain operations [2] (similar to the article&amp;#x27;s ones) provide more indications that such a hypothesis is not completely implausible. Though also far from strongly supporting it or anything, as there is no proper experiment design with control groups etc to make better conclusions.&lt;p&gt;[1] &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC2945313&amp;#x2F;&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC2945313&amp;#x2F;&lt;/a&gt;
[2] &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.medicaldesignandoutsourcing.com&amp;#x2F;report-suggests-brain-surgeons-could-catch-alzheimers-disease&amp;#x2F;&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.medicaldesignandoutsourcing.com&amp;#x2F;report-suggests-...&lt;/a&gt;</text><parent_chain><item><author>caycep</author><text>There is a line of research into the &amp;quot;transmissible&amp;#x27; phenomena of a lot of these neurodegen dz.    Epidemiologically, it&amp;#x27;s probably not infectious from one person to another bc we don&amp;#x27;t see spouses getting PD or AD often.   But there&amp;#x27;s interesting phenomena - i.e. one of the Parkinson&amp;#x27;s stem cell implantation trials got a lot of press after the trial (which failed, didn&amp;#x27;t show benefit) bc after subjects passed several years later and got autopsied, they found clumps of parkinsonian proteins (lewy bodies) on the histology slides of the implanted stem cells.&lt;p&gt;Similarly, there&amp;#x27;s some papers w&amp;#x2F; mice w&amp;#x2F; knockout Parkinsonian genes getting parkinsonian features and lewy bodies when injected w&amp;#x2F; abnormal misfolded synuclein from another mouse.&lt;p&gt;What exactly to do w&amp;#x2F; this, no one is entirely sure yet.</text></item></parent_chain></comment><story><title>Alzheimer’s cases tied to no-longer-used medical procedure</title><url>https://www.statnews.com/2024/01/29/first-transmitted-alzheimers-disease-cases-growth-hormone-cadavers/</url></story>
<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>foota</author><text>I guess if your brain proteins are mixing with someone elses you normally have a bigger issue.</text><parent_chain><item><author>caycep</author><text>There is a line of research into the &amp;quot;transmissible&amp;#x27; phenomena of a lot of these neurodegen dz.    Epidemiologically, it&amp;#x27;s probably not infectious from one person to another bc we don&amp;#x27;t see spouses getting PD or AD often.   But there&amp;#x27;s interesting phenomena - i.e. one of the Parkinson&amp;#x27;s stem cell implantation trials got a lot of press after the trial (which failed, didn&amp;#x27;t show benefit) bc after subjects passed several years later and got autopsied, they found clumps of parkinsonian proteins (lewy bodies) on the histology slides of the implanted stem cells.&lt;p&gt;Similarly, there&amp;#x27;s some papers w&amp;#x2F; mice w&amp;#x2F; knockout Parkinsonian genes getting parkinsonian features and lewy bodies when injected w&amp;#x2F; abnormal misfolded synuclein from another mouse.&lt;p&gt;What exactly to do w&amp;#x2F; this, no one is entirely sure yet.</text></item></parent_chain></comment><story><title>Alzheimer’s cases tied to no-longer-used medical procedure</title><url>https://www.statnews.com/2024/01/29/first-transmitted-alzheimers-disease-cases-growth-hormone-cadavers/</url></story>