<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>sitharus</author><text>Anti-androgens and GnRH agonists like Spironolactone, Cyproterone Acetate, Goserelin Acetate, Bicalutamide to name a few. Also to a lesser extent 5α-reductase inhibitors like finasteride (Propecia) which only suppress the more potent dihydrotestosterone.&lt;p&gt;All of these work by suppressing androgen production (mostly testosterone and dihydrotestosterone), this will suppress most of the male libido. While they don&amp;#x27;t remove the ability to get an erection if you try, they will prevent the hormonal lead-up that would normally lead to one. You&amp;#x27;ll likely stop thinking about sex entirely, there won&amp;#x27;t be much of a drive. GnRH agonists like Goserelin Acetate (zolodex) are highly effective, spironolactone is very weak and a potent diuretic.&lt;p&gt;On the downside... an adult human body expects to have a dominant sex hormone, either testosterone or oestrogen, and a lot of things hang off this. For one, initial breast growth is inhibited by testosterone, so you will likely develop gynecomastia (unwanted breast development). Your body hair will reduce, though facial hair is mostly unaffected, and your skin will become softer. Long term you are at increased risk of developing osteoporosis, and your testes and genitals will shrink. Sperm count and viability will reduce, though for some people this is recoverable.&lt;p&gt;It will halt any male pattern baldness though.&lt;p&gt;Most of these drugs are used for treatment of prostate and testicular cancer, so their effects are well known.</text><parent_chain><item><author>faeyanpiraat</author><text>Do you happen to know any drug or supplement which helps Preventing an erection?&lt;p&gt;(Serious question)</text></item><item><author>Traubenfuchs</author><text>Sildenafil (Viagra) is old and busted. Tadalafil (Cyalis) has a longer duration of action and less side effects (17 vs 4 hours half life) due to a lesser reduction of PDEs besides the targeted PDE5.&lt;p&gt;Additionally, studies show that daily tadalafil is much better in managing or even “curing“ ED.&lt;p&gt;Want a little extra boost? Consume 6g of L-Citrullin a day. One of the few proven, freely and cheaply available substances that improve erections. L-Citrulline gets converted to L-Arginin and is better that L-Arginin supplementation.&lt;p&gt;If you want to increase the half life, consume pomegranate juice.&lt;p&gt;Warning, L-Citrullin and PDE5 inhibitors potentiate each other.&lt;p&gt;Need even more arguments? Daily PDE5 inhibitors are cardioprotective and cardioregenerative.&lt;p&gt;Studies used 5mg Tadalafil daily, I am on 20 -why not?&lt;p&gt;&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC7261690&amp;#x2F;&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC7261690&amp;#x2F;&lt;/a&gt;</text></item></parent_chain></comment><story><title>Suicides among Swedish men decreased after Viagra became more affordable</title><url>https://sapienjournal.org/suicides-among-swedish-men-decreased-after-viagra-became-more-affordable/</url></story>
<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>AdrianB1</author><text>There is a widely circulated rumor that in the Romanian army they used to put a small quantity of bromide (sodium or potassium? don&amp;#x27;t know) in the evening tea; it is not supposed to prevent an erection, but total lack of sexual desire. This was 30-40 years ago, I was not able to find any official documents related to that, but any men over 50 years old is telling that story.</text><parent_chain><item><author>faeyanpiraat</author><text>Do you happen to know any drug or supplement which helps Preventing an erection?&lt;p&gt;(Serious question)</text></item><item><author>Traubenfuchs</author><text>Sildenafil (Viagra) is old and busted. Tadalafil (Cyalis) has a longer duration of action and less side effects (17 vs 4 hours half life) due to a lesser reduction of PDEs besides the targeted PDE5.&lt;p&gt;Additionally, studies show that daily tadalafil is much better in managing or even “curing“ ED.&lt;p&gt;Want a little extra boost? Consume 6g of L-Citrullin a day. One of the few proven, freely and cheaply available substances that improve erections. L-Citrulline gets converted to L-Arginin and is better that L-Arginin supplementation.&lt;p&gt;If you want to increase the half life, consume pomegranate juice.&lt;p&gt;Warning, L-Citrullin and PDE5 inhibitors potentiate each other.&lt;p&gt;Need even more arguments? Daily PDE5 inhibitors are cardioprotective and cardioregenerative.&lt;p&gt;Studies used 5mg Tadalafil daily, I am on 20 -why not?&lt;p&gt;&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC7261690&amp;#x2F;&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.ncbi.nlm.nih.gov&amp;#x2F;pmc&amp;#x2F;articles&amp;#x2F;PMC7261690&amp;#x2F;&lt;/a&gt;</text></item></parent_chain></comment><story><title>Suicides among Swedish men decreased after Viagra became more affordable</title><url>https://sapienjournal.org/suicides-among-swedish-men-decreased-after-viagra-became-more-affordable/</url></story>