<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>pfdietz</author><text>I believe one of the effects of measles infection is that sort of wiping of immune memory.  It&amp;#x27;s one of the things that makes childhood measles so nasty.&lt;p&gt;&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.nature.com&amp;#x2F;articles&amp;#x2F;d41586-019-03324-7&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.nature.com&amp;#x2F;articles&amp;#x2F;d41586-019-03324-7&lt;/a&gt;</text><parent_chain><item><author>jokowueu</author><text>This is a bit offtopic . Is it possible to wipe that memory? Sounds like it would resolve all Autoimmune disease</text></item><item><author>russdill</author><text>The number of things your immune system knows about is absolutely enormous and grows everyday. Vaccinations are a tiny drop in the bucket</text></item><item><author>p1mrx</author><text>It seems that mRNA vaccines are becoming like antivirus software updates: inject the whole &amp;quot;database&amp;quot; and your body scans for currently-known threats.  Does the immune system have a capacity limit?&lt;p&gt;I wonder if the technology will reach a point where we can print mRNA on demand.  Could we build a database of bacteriophage viruses that target various strains of bacteria, and use custom-printed mRNA to produce the correct virus when someone has a bacterial infection?</text></item></parent_chain></comment><story><title>Universal flu vaccine against all known subtypes takes promising first steps</title><url>https://www.science.org/doi/10.1126/science.abm0271</url></story>
<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>alphazard</author><text>Many autoimmune diseases don&amp;#x27;t appear to be caused by immune memory, at least alone.  There is evidence for cyclic inflammation by the innate immune system and also latent inflammation from gut bacteria and their outputs.&lt;p&gt;What you are describing (bone marrow radiation) has been used to treat Multiple Sclerosis.  But diets (which radically change gut bacteria) have also been used to treat MS.  So it&amp;#x27;s complicated, and it&amp;#x27;s possible for what is currently considered a single disease to be a common symptomatology for different root causes.</text><parent_chain><item><author>jokowueu</author><text>This is a bit offtopic . Is it possible to wipe that memory? Sounds like it would resolve all Autoimmune disease</text></item><item><author>russdill</author><text>The number of things your immune system knows about is absolutely enormous and grows everyday. Vaccinations are a tiny drop in the bucket</text></item><item><author>p1mrx</author><text>It seems that mRNA vaccines are becoming like antivirus software updates: inject the whole &amp;quot;database&amp;quot; and your body scans for currently-known threats.  Does the immune system have a capacity limit?&lt;p&gt;I wonder if the technology will reach a point where we can print mRNA on demand.  Could we build a database of bacteriophage viruses that target various strains of bacteria, and use custom-printed mRNA to produce the correct virus when someone has a bacterial infection?</text></item></parent_chain></comment><story><title>Universal flu vaccine against all known subtypes takes promising first steps</title><url>https://www.science.org/doi/10.1126/science.abm0271</url></story>