<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>irthomasthomas</author><text>Metformin.&lt;p&gt;Research in humans suggests that metformin can impact mortality. A meta-analysis published in 2017 that included 53 different studies concluded that metformin reduces all-cause mortality and diseases of aging, independent of its effect on diabetes.&lt;p&gt;Also, combinations of Metformin, rapamycin and resveratrol, and NMNs.&lt;p&gt;Davis Sinclaire is probably the leading expert on those, now. He is professor of genetics at Harvard.&lt;p&gt;&lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;youtube.com&amp;#x2F;watch?v=bRWT7hVgwuM&quot;&gt;https:&amp;#x2F;&amp;#x2F;youtube.com&amp;#x2F;watch?v=bRWT7hVgwuM&lt;/a&gt;</text><parent_chain><item><author>safety1st</author><text>So in the science of fitness, there&amp;#x27;s a lot of woo, but there are a few really clear wins. One such example in weight lifting is supplementing creatine. It&amp;#x27;s well researched, fairly inexpensive, the performance improvements are significant and well documented, and it&amp;#x27;s very safe with side effects being mild and rare. Once you&amp;#x27;re actually doing the exercise and nutrition part more or less right, it&amp;#x27;s hard to argue against supplementing creatine. It&amp;#x27;s used by the vast majority of professional bodybuilders and most experienced weight lifters.&lt;p&gt;Is there anything similar in the science of anti-aging? Where (A) The body of research is large, well established, and mostly uncontroversial; (B) The benefits and safety profile are good; (C) The majority of people who are serious about this stuff use it&amp;#x2F;take it&amp;#x2F;do it.</text></item><item><author>tysam_and</author><text>Anti-aging is a hard problem, Rapamycin is most certainly not the most powerful anti-aging drug from my best understanding, it just targets 1 of 7 or 8 critical areas that are implicated in the aging formula.&lt;p&gt;If you want to start down the rabbithole (SENS talks can be trusted and are good, well-backed by science, etc etc. Have been derailed by some drama recently, but still, they&amp;#x27;ve really done a lot) then you can start by going to the rejuvenation roadmap: &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.lifespan.io&amp;#x2F;road-maps&amp;#x2F;the-rejuvenation-roadmap&amp;#x2F;&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.lifespan.io&amp;#x2F;road-maps&amp;#x2F;the-rejuvenation-roadmap&amp;#x2F;&lt;/a&gt;&lt;p&gt;A little further (Aubrey de Grey, from SENS originally): &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.ted.com&amp;#x2F;talks&amp;#x2F;aubrey_de_grey_a_roadmap_to_end_aging?language=tt&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.ted.com&amp;#x2F;talks&amp;#x2F;aubrey_de_grey_a_roadmap_to_end_ag...&lt;/a&gt;&lt;p&gt;If you want to lose 4-5+ hours (minimum -- think TVTropes level of rabbithole addiction here), then here is your next free joyride. It&amp;#x27;s a fun one, I&amp;#x27;ve been pretty interested in it as it&amp;#x27;s continued to have developed. Have fun reading the saga: &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.reddit.com&amp;#x2F;r&amp;#x2F;sleephackers&amp;#x2F;comments&amp;#x2F;ohfetn&amp;#x2F;turnbuckle_longecity_mitochondrial_fissionfusion&amp;#x2F;&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.reddit.com&amp;#x2F;r&amp;#x2F;sleephackers&amp;#x2F;comments&amp;#x2F;ohfetn&amp;#x2F;turnbu...&lt;/a&gt;</text></item></parent_chain></comment><story><title>Rapamycin: The unlucky history of an anti-aging drug</title><url>https://bigthink.com/health/unlucky-history-rapamycin-anti-aging/</url></story>
<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>xiphias2</author><text>By far the most important thing in anti aging that checks all boxes is excercise and getting nutrition right (no excess fat).&lt;p&gt;Most of the interesting stuff happens when you focus on just A part: Yamanaka factors are both super powerful, established as reversing the probably most important hallmark of aging and super dangerous (causes cancer) at the same time.&lt;p&gt;What&amp;#x27;s promising is the pace of research: in 20 years there&amp;#x27;s a good chance to have real safe anti-aging available, but we still need to survive until then.</text><parent_chain><item><author>safety1st</author><text>So in the science of fitness, there&amp;#x27;s a lot of woo, but there are a few really clear wins. One such example in weight lifting is supplementing creatine. It&amp;#x27;s well researched, fairly inexpensive, the performance improvements are significant and well documented, and it&amp;#x27;s very safe with side effects being mild and rare. Once you&amp;#x27;re actually doing the exercise and nutrition part more or less right, it&amp;#x27;s hard to argue against supplementing creatine. It&amp;#x27;s used by the vast majority of professional bodybuilders and most experienced weight lifters.&lt;p&gt;Is there anything similar in the science of anti-aging? Where (A) The body of research is large, well established, and mostly uncontroversial; (B) The benefits and safety profile are good; (C) The majority of people who are serious about this stuff use it&amp;#x2F;take it&amp;#x2F;do it.</text></item><item><author>tysam_and</author><text>Anti-aging is a hard problem, Rapamycin is most certainly not the most powerful anti-aging drug from my best understanding, it just targets 1 of 7 or 8 critical areas that are implicated in the aging formula.&lt;p&gt;If you want to start down the rabbithole (SENS talks can be trusted and are good, well-backed by science, etc etc. Have been derailed by some drama recently, but still, they&amp;#x27;ve really done a lot) then you can start by going to the rejuvenation roadmap: &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.lifespan.io&amp;#x2F;road-maps&amp;#x2F;the-rejuvenation-roadmap&amp;#x2F;&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.lifespan.io&amp;#x2F;road-maps&amp;#x2F;the-rejuvenation-roadmap&amp;#x2F;&lt;/a&gt;&lt;p&gt;A little further (Aubrey de Grey, from SENS originally): &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.ted.com&amp;#x2F;talks&amp;#x2F;aubrey_de_grey_a_roadmap_to_end_aging?language=tt&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.ted.com&amp;#x2F;talks&amp;#x2F;aubrey_de_grey_a_roadmap_to_end_ag...&lt;/a&gt;&lt;p&gt;If you want to lose 4-5+ hours (minimum -- think TVTropes level of rabbithole addiction here), then here is your next free joyride. It&amp;#x27;s a fun one, I&amp;#x27;ve been pretty interested in it as it&amp;#x27;s continued to have developed. Have fun reading the saga: &lt;a href=&quot;https:&amp;#x2F;&amp;#x2F;www.reddit.com&amp;#x2F;r&amp;#x2F;sleephackers&amp;#x2F;comments&amp;#x2F;ohfetn&amp;#x2F;turnbuckle_longecity_mitochondrial_fissionfusion&amp;#x2F;&quot; rel=&quot;nofollow&quot;&gt;https:&amp;#x2F;&amp;#x2F;www.reddit.com&amp;#x2F;r&amp;#x2F;sleephackers&amp;#x2F;comments&amp;#x2F;ohfetn&amp;#x2F;turnbu...&lt;/a&gt;</text></item></parent_chain></comment><story><title>Rapamycin: The unlucky history of an anti-aging drug</title><url>https://bigthink.com/health/unlucky-history-rapamycin-anti-aging/</url></story>