<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>ljm</author><text>I appreciate the concern but, honestly, it&amp;#x27;s exhausting to keep fielding &amp;#x27;have you tried...&amp;#x27;, &amp;#x27;have you looked into...&amp;#x27;, &amp;#x27;have you explored...&amp;#x27; questions.&lt;p&gt;I get that it comes from a good place, but I&amp;#x27;m sharing my experience, not asking for advice.&lt;p&gt;The best help you and others can offer is to just listen, instead of offering another solution.&lt;p&gt;There are two replies to me in the &amp;#x27;have you tried&amp;#x27; vein. I&amp;#x27;m not aiming it at you specifically, just trying to stop a pattern.</text><parent_chain><item><author>lost-found</author><text>You ever look into ketamine for treating depression?&lt;p&gt;Self medicated this past weekend and had some major breakthroughs with my long time depression&amp;#x2F;suicidal intrusive thoughts. Nice thing is you don’t have to stay on it unlike other antidepressants—I would never do a medication that you have to constantly take.</text></item><item><author>ljm</author><text>This was one of the factors that made me think twice about going back on anti-depressants, until I made peace with the fact that my ability to orgasm wasn&amp;#x27;t going to pull me out of the hole I was in. It&amp;#x27;s a shitty choice but the desire to not be suicidal forces your hand.&lt;p&gt;It&amp;#x27;s literally like flipping a switch. One day, the plumbing works. The next day, it doesn&amp;#x27;t. Many times I&amp;#x27;d just give up, out of boredom.&lt;p&gt;The side-effects are clearly stated but to use myself as an example, I vastly underestimated just how strong they would be.&lt;p&gt;That said, if you&amp;#x27;re dealing with the big black dog as it were, don&amp;#x27;t use it as a reason to avoid anti-depressants if you really need them. Keep your doctor up to date about the side-effects so they can adjust your prescription. And don&amp;#x27;t be shy just because you&amp;#x27;re talking about your private parts.&lt;p&gt;And make sure you have a therapist too.</text></item></parent_chain></comment><story><title>Post-SSRI sexual dysfunction</title><url>https://rxisk.org/post-ssri-sexual-dysfunction-pssd/</url></story>
<instructions>Your goal is to analyze the following comment and estimate how highly it will be upvoted by the Hacker News community.</instructions><comment><author>cwkoss</author><text>Ketamine can be pretty rough on the bladder and kidneys.  Please read up on the risks.  It is definitely dangerous to take recreational doses several times per week - it seems that low&amp;#x2F;moderate doses every week or two avoids most of the problems while still providing therapeutic effects, but definitely keep an eye on the health of those systems, ideally with letting your doctor know so they can help.&lt;p&gt;Many of users on &amp;#x2F;r&amp;#x2F;researchchemicals using either ket or novel analogs at recreational doses regularly for both fun and depression relief end up with bladder issues after over-consuming for a period - so while it&amp;#x27;s a promising depression treatment, I&amp;#x27;d recommend caution around dosage and frequency and titrating to find your minimum effective dose.</text><parent_chain><item><author>lost-found</author><text>You ever look into ketamine for treating depression?&lt;p&gt;Self medicated this past weekend and had some major breakthroughs with my long time depression&amp;#x2F;suicidal intrusive thoughts. Nice thing is you don’t have to stay on it unlike other antidepressants—I would never do a medication that you have to constantly take.</text></item><item><author>ljm</author><text>This was one of the factors that made me think twice about going back on anti-depressants, until I made peace with the fact that my ability to orgasm wasn&amp;#x27;t going to pull me out of the hole I was in. It&amp;#x27;s a shitty choice but the desire to not be suicidal forces your hand.&lt;p&gt;It&amp;#x27;s literally like flipping a switch. One day, the plumbing works. The next day, it doesn&amp;#x27;t. Many times I&amp;#x27;d just give up, out of boredom.&lt;p&gt;The side-effects are clearly stated but to use myself as an example, I vastly underestimated just how strong they would be.&lt;p&gt;That said, if you&amp;#x27;re dealing with the big black dog as it were, don&amp;#x27;t use it as a reason to avoid anti-depressants if you really need them. Keep your doctor up to date about the side-effects so they can adjust your prescription. And don&amp;#x27;t be shy just because you&amp;#x27;re talking about your private parts.&lt;p&gt;And make sure you have a therapist too.</text></item></parent_chain></comment><story><title>Post-SSRI sexual dysfunction</title><url>https://rxisk.org/post-ssri-sexual-dysfunction-pssd/</url></story>