Currently it is possible to stupidly lose mempool data by calling the rpc "savemempool" before the previous stored mempool has been read and processed to the memory mempool.

I haven't looked at the code yet, but at minimum one ugly solution would be to have a global g_is_mempool_read_finished (or something of the short) that starts false and gets sets to true once the reading is reading processing of mempool.dat is successfully finished. The rpc savemempool checks this global on the start and returns a an error while it remains false.

if (block.GetBlockTime() > nAdjustedTime + MAX_FUTURE_BLOCK_TIME)
        return state.Invalid(false, REJECT_INVALID, "time-too-new", "block timestamp too far in the future");
    
    
    if((block.nVersion < 2 && nHeight >= consensusParams.BIP34Height) ||
       (block.nVersion < 3 && nHeight >= consensusParams.BIP66Height) ||
       (block.nVersion < 4 && nHeight >= consensusParams.BIP65Height))
            return state.Invalid(false, REJECT_OBSOLETE, strprintf("bad-version(0x%08x)", block.nVersion),
                                 strprintf("rejected nVersion=0x%08x block", block.nVersion));
    return true;
}
/** NOTE: This function is not currently invoked by ConnectBlock(), so we
 *  should consider upgrade issues if we change which consensus rules are
 *  enforced in this function (eg by adding a new consensus rule). See comment
 *  in ConnectBlock().
 *  Note that -reindex-chainstate skips the validation that happens here!
 */
static bool ContextualCheckBlock(const CBlock& block, CValidationState& state, const Consensus::Params& consensusParams, const CBlockIndex* pindexPrev)
{
    const int nHeight = pindexPrev == nullptr ? 0 : pindexPrev->nHeight + 1;
    
    int nLockTimeFlags = 0;
    if (VersionBitsState(pindexPrev, consensusParams, Consensus::DEPLOYMENT_CSV, versionbitscache) == ThresholdState::ACTIVE) {
        nLockTimeFlags |= LOCKTIME_MEDIAN_TIME_PAST;
    }
    int64_t nLockTimeCutoff = (nLockTimeFlags & LOCKTIME_MEDIAN_TIME_PAST)
                              ? pindexPrev->GetMedianTimePast()
                              : block.GetBlockTime();
    
    for (const auto& tx : block.vtx) {