As of #11466 we no longer have any logic to prevent a user from opening a wallet twice in two instances simultaneously. Not only could this break BDB (without the -privdb=false option, which I have really no idea why we even have a tuneable option for that), but we certainly don't have logic to handle such a case gracefully. It was noted in the original PR's description, but somehow was never followed up on before merge.
else
        LogPrintf("Validating signatures for all blocks.\n");
    if (gArgs.IsArgSet("-minimumchainwork")) {
        const std::string minChainWorkStr = gArgs.GetArg("-minimumchainwork", "");
        if (!IsHexNumber(minChainWorkStr)) {
            return InitError(strprintf("Invalid non-hex (%s) minimum chain work value specified", minChainWorkStr));
        }
        nMinimumChainWork = UintToArith256(uint256S(minChainWorkStr));
    } else {
        nMinimumChainWork = UintToArith256(chainparams.GetConsensus().nMinimumChainWork);
    }
    LogPrintf("Setting nMinimumChainWork=%s\n", nMinimumChainWork.GetHex());
    if (nMinimumChainWork < UintToArith256(chainparams.GetConsensus().nMinimumChainWork)) {
        LogPrintf("Warning: nMinimumChainWork set below default value of %s\n", chainparams.GetConsensus().nMinimumChainWork.GetHex());
    }
    
    int64_t nMempoolSizeMax = gArgs.GetArg("-maxmempool", DEFAULT_MAX_MEMPOOL_SIZE) * 1000000;
    int64_t nMempoolSizeMin = gArgs.GetArg("-limitdescendantsize", DEFAULT_DESCENDANT_SIZE_LIMIT) * 1000 * 40;
    if (nMempoolSizeMax < 0 || nMempoolSizeMax < nMempoolSizeMin)
        return InitError(strprintf(_("-maxmempool must be at least %d MB"), std::ceil(nMempoolSizeMin / 1000000.0)));
    
    
    if (gArgs.IsArgSet("-incrementalrelayfee"))
    {
        CAmount n = 0;
        if (!ParseMoney(gArgs.GetArg("-incrementalrelayfee", ""), n))
            return InitError(AmountErrMsg("incrementalrelayfee", gArgs.GetArg("-incrementalrelayfee", "")));
        incrementalRelayFee = CFeeRate(n);
    }