I've observed that when React's profiling mode is enabled, updating the profiling fields [here](https://github.com/facebook/react/blob/1d25aa5787d4e19704c049c3cfa985d3b5190e0d/packages/react-reconciler/src/ReactProfilerTimer.js#L46) and [here](https://github.com/facebook/react/blob/1d25aa5787d4e19704c049c3cfa985d3b5190e0d/packages/react-reconciler/src/ReactProfilerTimer.js#L69-L71) during the _render_ phase seems to cause a significant deopt in [`getHostSibling`](https://github.com/facebook/react/blob/1d25aa5787d4e19704c049c3cfa985d3b5190e0d/packages/react-reconciler/src/ReactFiberCommitWork.js#L858-L898) during the _commit_ phase for Chrome only. (Neither Safari nor Firefox seem to be affected by this.)

I have created a repro case with inline annotations here:
https://github.com/bvaughn/react-profiling-v8-deopt-repro#about-this-repro-case

(Note that the above repo is private. Please tag me here if you need access.)
target.child = source.child;
  target.sibling = source.sibling;
  target.index = source.index;
  target.ref = source.ref;
  target.pendingProps = source.pendingProps;
  target.memoizedProps = source.memoizedProps;
  target.updateQueue = source.updateQueue;
  target.memoizedState = source.memoizedState;
  target.firstContextDependency = source.firstContextDependency;
  target.mode = source.mode;
  target.effectTag = source.effectTag;
  target.nextEffect = source.nextEffect;
  target.firstEffect = source.firstEffect;
  target.lastEffect = source.lastEffect;
  target.expirationTime = source.expirationTime;
  target.childExpirationTime = source.childExpirationTime;
  target.alternate = source.alternate;
  if (enableProfilerTimer) {
    target.actualDuration = source.actualDuration;
    target.actualStartTime = source.actualStartTime;
    target.selfBaseDuration = source.selfBaseDuration;
    target.treeBaseDuration = source.treeBaseDuration;
  }
  target._debugID = source._debugID;
  target._debugSource = source._debugSource;
  target._debugOwner = source._debugOwner;
  target._debugIsCurrentlyTiming = source._debugIsCurrentlyTiming;
  return target;
}