We could use:
https://github.com/mozilla/pdf.js/blob/c3d08580627471432a6ad0b2fdb948df64126afa/src/display/api.js#L929

and look at bit 4.

The following pdf:
https://orimi.com/pdf-test.pdf
is not editable in neither Acrobat nor Edge nor Foxit and nor Okular.
return this._pagesRotation;
  }
  /**
   * @param {number} rotation - The rotation of the pages (0, 90, 180, 270).
   */
  set pagesRotation(rotation) {
    if (!isValidRotation(rotation)) {
      throw new Error("Invalid pages rotation angle.");
    }
    if (!this.pdfDocument) {
      return;
    }
    
    rotation %= 360;
    if (rotation < 0) {
      rotation += 360;
    }
    if (this._pagesRotation === rotation) {
      return; 
    }
    this._pagesRotation = rotation;
    const pageNumber = this._currentPageNumber;
    const updateArgs = { rotation };