I've observed that when React's profiling mode is enabled, updating the profiling fields [here](https://github.com/facebook/react/blob/1d25aa5787d4e19704c049c3cfa985d3b5190e0d/packages/react-reconciler/src/ReactProfilerTimer.js#L46) and [here](https://github.com/facebook/react/blob/1d25aa5787d4e19704c049c3cfa985d3b5190e0d/packages/react-reconciler/src/ReactProfilerTimer.js#L69-L71) during the _render_ phase seems to cause a significant deopt in [`getHostSibling`](https://github.com/facebook/react/blob/1d25aa5787d4e19704c049c3cfa985d3b5190e0d/packages/react-reconciler/src/ReactFiberCommitWork.js#L858-L898) during the _commit_ phase for Chrome only. (Neither Safari nor Firefox seem to be affected by this.)

I have created a repro case with inline annotations here:
https://github.com/bvaughn/react-profiling-v8-deopt-repro#about-this-repro-case

(Note that the above repo is private. Please tag me here if you need access.)
current: Fiber,
  pendingProps: any,
  expirationTime: ExpirationTime,
): Fiber {
  let workInProgress = current.alternate;
  if (workInProgress === null) {
    
    
    
    
    
    workInProgress = createFiber(
      current.tag,
      pendingProps,
      current.key,
      current.mode,
    );
    workInProgress.elementType = current.elementType;
    workInProgress.type = current.type;
    workInProgress.stateNode = current.stateNode;
    if (__DEV__) {
      
      workInProgress._debugID = current._debugID;
      workInProgress._debugSource = current._debugSource;
      workInProgress._debugOwner = current._debugOwner;
    }