On Preparing a List of Random treatment Assigns
This paper presents the foundations of a computer oriented approach for preparing a list of random treatment assignments to be adopted in randomised controlled trials. Software is presented which can be applied in the earliest stage of clinical trials and bioequivalence assays. This allocation of patients to treatment in clinical trials ensures exactly equal treatment numbers. The investigation of the randomness properties of an assignment leads to the concept of a 'strong randomised list'. The new approach introduced in this note is based on thresholds and produces a strong randomised list of treatment assignments.