You will be presented with the full text of a biomedical research paper. Please write an abstract for this paper. Your response should include the abstract and no additional text.

Paper text:
isolation of the cmv virus or detection of its proteins or nucleic acid in any body fluid or tissue specimen is defined as  cmv infection  .
a 10-year - old girl was admitted frequently for vomiting and colicky watery diarrhea starting one month after renal transplantation from a non - relative living donor .
anti cmv igm titer was negative before and after transplantation . on colonoscopy large aphthous like lesions
cmv pcr of the lesion was strongly positive ( > 2000 copies / ml ) .
usually cmv infected patients present with renal dysfunction after renal transplantation but other organ involvements must not be ignored .
cytomegalovirus ( cmv ) infection is one of the most important causes of morbidity and mortality in kidney transplant recipients .
it is diagnosed by a combination of clinical symptoms of the gastrointestinal tract , finding of microscopic mucosal lesions on endoscopy and demonstrating cmv infection .
the endoscopic lesions range from exudates , patchy erythema , mucosal erosions and edema , to deep ulcers and pseudo tumors .
isolation of the cmv virus or detection of its proteins or nucleic acid in body fluids or tissue specimens is defined as  cmv infection  .
cmv infects epithelial and mesenchymal cells , destructs the cells and causes ulcers on the epithelial layers of different organs including intestine and colon .
reported cases are referred mainly to adults with predisposing conditions like diabetes mellitus and there are rarely reports on cmv colitis in children after kidney transplantation .
we report a 10-year - old girl who experienced cmv colitis after receiving a kidney from a cmv negative live donor to alert kidney transplant teams to have this infection in mind , despite being rare , although important .
one month after renal transplantation from a non - relative living donor , at age of 10 years , the patient was hospitalized due to vomiting and colicky watery diarrhea .
she was receiving cyclosporine ( 5mg / kg / day ) , prednisolone ( 0.7mg / kg / day ) and mycophenolate mofetil ( mmf ) ( 1200mg / m / day ) as immunosuppressive therapies .
three months later , she was admitted again for vomiting , abdominal pain , watery - non bloody diarrhea and low grade fever .
physical examination showed fever ( oral temperature 38.5c ) , blood pressure 100/75mmhg , pulse rate 85/min .
initial laboratory investigations showed : hemoglobin 11.5 g / dl , wbc 27200/mm ( neutrophils : 92% ) , platelets 325000/mm ) .
serum creatinine , blood urea nitrogen ( bun ) and liver function tests were normal ( cr 0.7 mg / dl , bun 17mg / dl , ast 32iu / l , alt 52iu / l , total bilirubin 1.8 mg / dl ) .
anti cmv igg titer before and after transplantation was ( 7 iu / ml and 15 iu / ml respectively ) .
anti cmv igm titer was negative before transplantation and did not change significantly after transplantation .
both in recipient and donor , urine and serum cmv pcr testing were negative after transplantation .
stool examinations ( 3 times ) revealed many white blood cells ( 100% neutrophils ) and no red blood cells .
on colonoscopy large aphthous like lesions were detected in all segments of the colon ( fig .
endoscopic appearance of aphthous like lesions of colon in the patient histopathologic examination showed acute inflammation and inclusion bodies ( fig .
cmv pcr of the colon lesions was strongly positive ( > 2000 copies / ml ) .
after 3 weeks , gancyclovir was changed to valganciclovir ( 15 mg / kg / day , po ) and continued for another 3 months .
histopathologic evaluation of aphthous lesions of colon demonstrated acute inflammation and characteristic cytomegalovirus ( cmv ) inclusion bodies also , azathioprine ( 2.5mg / kg / day ) was substituted for mmf .
renal function tests remained stable throughout the treatment course ( serum creatinine 0.6mg / dl ) .
in reported case it was seen that a kidney transplanted patient presents only with intestinal signs and symptoms of cmv infection .
it is more fashionable that cmv infected patients present with renal dysfunction in addition to other organ involvement after renal transplantation .
our case is the first pediatric report  as far as we know  of cmv colitis in renal transplantation . in kidney transplant recipients especially those who are on therapy with immunosuppressive drugs like mmf
we should consider polymerase chain reaction ( pcr ) examination of colon specimens in addition to serologic tests to diagnose cmv gastrointestinal disease in suspicious cases . in cmv infected graft recipients , anorexia , abdominal pain ,
watery non - bloody diarrhea and vomiting may progress to gi bleeding and pseudo - obstruction in severe cases .
cmv manifests during the first 2 - 5 months after solid organ transplantation , when the immunosuppressive drugs are given in the maximum doses .
knowledge about cmv gastrointestinal disease in the pediatric kidney transplant patients is limited . in our patient antibodies of cmv
this may be due to decreased antibody production in severe acute cmv infection or decreased immune response by mmf .
bueno et al reported sixteen episodes of cmv disease without serious morbidity in 10 of 41 children undergoing intestinal transplantation .
lortholary et al reported a case of primary cmv infection associated with the onset of ulcerative colitis .
the patient 's main symptoms were bloody diarrhea and fever . in a survey , reported by blanche
et al , the most common viral infection in organ transplant recipients older than 5 years was cmv infection .
however , prescribing mmf , high doses of methyprednisolone ( solumedrol ) and also tacrolimus are associated with increased risk of cmv infection .
having considered all facts mentioned above , we could not identify any specific source for cmv infection in our patient .
severe clinical infections are seen in patients receiving mmf , prednisolone and cyclosporine . in one study , patients receiving mmf had higher risk for cmv infection compared to patients receiving azathioprine and placebo . in recent years , cmv infection in hospitalized patients , despite receiving prophylaxis , the incidence of cmv infection is increasing .
if not received prophylaxis , the patient must be monitored closely for symptoms and signs to reduce morbidity and mortality .
although cmv infected patients usually present with renal dysfunction after renal transplantation , other organ involvements must not be ignored , as here reported patient presented only intestinal signs and symptoms of cmv infection .
backgroundcytomegalovirus is an important infection in kidney transplantation . 
 isolation of the cmv virus or detection of its proteins or nucleic acid in any body fluid or tissue specimen is defined as  cmv infection.case presentationa 10-year - old girl was admitted frequently for vomiting and colicky watery diarrhea starting one month after renal transplantation from a non - relative living donor . 
 cr , bun , serum electrolytes and also liver function tests were normal . 
 anti cmv igm titer was negative before and after transplantation . on colonoscopy large aphthous like lesions 
 were detected in the colon . 
 cmv pcr of the lesion was strongly positive ( > 2000 copies / ml ) . 
 the patient received ganciclovir.conclusionusually cmv infected patients present with renal dysfunction after renal transplantation but other organ involvements must not be ignored . 
 we report a patient presenting only with intestinal signs and symptoms of cmv infection .