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worldwide postpartum infection is estimated to occur in 6% of all deliveries 2 and cause 510% of all maternal deaths 3 .
it is a serious , rapidly progressive , and life - threatening condition . despite preventive efforts , antibiotic and early treatment intervention , severe complications can occur primary caused by the pyogenic exotoxin a , which is responsible for fever , toxic shock syndrome , and multiple tissue injury 3 .
a 34-year - old woman , gravida 4 , para 3 , was presented to the obstetric department for labor induction , because of suspected macrosomic fetus at the 39th gestational week .
her medical history was unremarkable ; apart from periodic depression , whiplash and overweight ( bmi 34 ) .
she entered the active phase of labor 6  h after amniotomy exhibiting clear amnion fluid .
oxytocin was used to augment the labor for 4  h. she gave spontaneous birth to a male infant weighting 4230  g with apgar score of 7 and 10 at 1 and 5  min , respectively .
approximately 24  h postpartum , the patient was readmitted to the hospital complaining of pain and chills .
physical examination revealed hypotension ( 96/72  mmhg ) , tachycardia ( 112 ) , fever , oliguria , generalized abdominal tenderness , especially in both lower quadrants with guarding , peritoneal signs , and an enlarged uterus that reached the umbilicus .
after culture samples were collected , intravenous antibiotic therapy with metronidazole and cefuroxime was initiated .
laboratory exams revealed elevated crp and creatinine , normal white blood cell counts , hemoglobin , and platelets .
an abdominal ct - scan with intravenous contrast demonstrated an enlarged uterus and ascites ( 36  h postpartum , 8  h after readmission ) ( fig.1a ) . due to circulatory instability during the ct scan
, the patient was transferred to the intensive care unit ( icu ) for supportive care .
after circulatory stabilization , the patient was taken to the operation theater ( 38  h postpartum , 12  h after readmission ) for manual exploration of the uterus due to progressive elevation of crp and leucocytosis .
this procedure did not reveal any retained placental tissue nor any signs of uncontrolled hemorrhage .
the antibiotic therapy was changed to intravenous broad - spectrum meropenem and metronidazole . during icu readmission the patient developed fulminate circulatory shock , despite fluid resuscitation and heavy vasopressor therapy .
cardiac arrest occurred , but one cycle of basic cardiopulmonary resuscitation combined with 1  mg of intravenous adrenaline , brought the patient back to sinus rhythm .
a skilled cardiologist performed transthoracic echocardiography ( tte ) , revealing both right and left ventricular heart failure with a lowered ejection fraction , estimated less than 20% .
the patient was transferred to the highly specialized thoracic intensive care unit ( ticu ) ( 38  h postpartum and 15  h after readmission ) , here , she was connected to invasive cardiopulmonary support ( cps ) for 3  days .
the cardiac failure reversed and the kidney function slowly improved . both urine sample and culture from vagina on the date of readmission revealed group a streptococcus
one  week later , the patient returned to the regional icu in a stable condition , intubated , and sedated .
after arrival , she became circulatory unstable again , her temperature increased to above 42c , and she needed active cooling , induced by continuous venous hemodiafiltration ( cvvhdf ) . a new ct scan raised suspicion of necrosis in the uterus , which in turn was suspected to be the result of a thrombosis in the right uterine artery ( fig.1b ) .
the uterus was necrotic and enlarged ( 21    16    13  cm ) .
several septic thromboemboli were present in uterine artery .  despite intensive care management and adequate resuscitative efforts , the need of respiratory assistance and dialysis continued the days following hysterectomy .
clinical examination revealed altered consciousness , paralysis of all four extremities with absent of tendon reflexes , but preserved eye movements and oculus reflex .
mri - scan , eeg ( electroencephalography ) , and lumbar puncture were performed , but no obvious explanation for the condition was found by these procedures .
the patient fulfilled the clinical criteria of severe critical illness polyneuropathy ( cip ) 5 .
she was transferred to a highly specialized department for neurorehabilitation and is still patient at the center ( 4  months postpartum )
as sterile techniques and antibiotic treatment became standard , the morbidity and mortality from streptococcal puerperal infections declined . since 1980 , only small epidemics were reported 6 . during the past decade ,
a more virulent and aggressive group of gas has been seen and has now posed a global public health problem .
the prevalence of peripartum gas infections is 0.18% of total births and 1.4% of all women with puerperal fever 7 .
several bacteria can cause puerperal sepsis ; gas , group b streptococcus ( gbs ) , staphylococci , mycoplasma , chlamydia , clostridium difficile , coliform bacteria , and bacteria associated with polymicrobial vaginosis .
postpartum women have a 20-fold increase in incidence of gas and gbs compare to nonpregnant women 8 .
pregnancy is a highly immunomodulated state that permits implantation and development of the immunologically distinct fetus , thereby resulting in a vulnerable genital tract , more accessible for infection .
the translocation from vagina can be caused by maternal colonization or nosocomial exposure at parturition .
bacteria can also enter through cesarean section incision or result from a distal infection ( i.e. , pharyngitis ) traveling through maternal bloodstream .
the diagnosis of gas as cause of puerperal sepsis was , in this case , demonstrated by the isolation of gas from both urine sample and culture from vagina .
later , minor somatic complaints can quickly progress to septic shock , as effects of the exotoxin a manifestation .
fever , abdominal pain , and heavily vaginal bleeding are common symptoms of the gas infection .
unexplained systemic symptoms in the early postpartum period should result in detailed anamnesis and physical examination .
rapidly initiated treatment with antibiotic immediate after collecting cultures is crucial and usually produces a cure .
gas and exotoxin a produce rapid skin and soft tissue necrosis , fever , septic shock , and multiple organ failure with mortality rate up to 50% 3 .
gas produced toxins allow the necrosis of tissue and the local clotting of blood vessels produces a life - threatening situation , where gas are protected against the action of antibiotics and the toxin continues destruction producing widespread organ failure .
this patient presented with a severe gas infection and streptococcal toxic shock syndrome in the postpartum period .
the presence of the above indicates that gas is sequestered in an endometrial site large enough both to be untreatable by antibiotics and to release enough toxin into the vasculary system to produce septic shock .
as soon as gas is suspected and the patient fulfills the sepsis criteria , admission to the icu should be considered .
focus on multiorgan dysfunction , including early tte , is essential . illustrated in this case , fast admission to the ticu gives the opportunity of cps and is crucial and lifesaving .
but as also illustrated , early hysterectomy or other aggressive surgery can be necessary to stop the organ damage .
our case report illustrates that puerperal infection with gas can present with few unspecific symptoms and rapidly progress to a life - threatening condition .
therefore , we suggest that gas infection should be on the list of differential diagnosis for all postpartum women with unexplained systemic symptoms .
key clinical messagepuerperal infection with group a streptococcus ( gas ) can present with few symptoms and rapidly progress to a life - threatening condition . 
 often , the infection can be treated with antibiotics . 
 delay in diagnosis increases risk of sepsis , multiorgan failure , and death . 
 gas infection is a differential diagnose for all postpartum women with unexplained symptoms .