You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["Outcome", "Participant", "Intervention"].

Please return the output as a JSON object of the format: {"Participant" : ["patients with COPD", ...], "Intervention" : ["Atenolol", ...], "Outcome" : ["blood pressure", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Reversal of skeletal effects of endocrine treatments in the Intergroup Exemestane Study . The adjuvant use of aromatase inhibitors in breast cancer is associated with adverse effects on bone health . We previously reported a decline in bone mineral density ( BMD ) following the switch from tamoxifen to exemestane in the Intergroup Exemestane Study ( IES ) . Here we report effects of endocrine treatment withdrawal on BMD , bone turnover markers ( BTM ) and fracture rates . 4,724 patients took part in IES , and 206 patients were included in a bone sub-study . BMD and BTM were assessed pre-randomization , during and after the end of treatment ( EOT ) . To evaluate treatment withdrawal effects , 12- and 24-month post EOT BMD results are available for 122 and 126 patients , respectively . Similar patient numbers had BTM measured post EOT . Following treatment withdrawal , the differences in BMD observed between the two endocrine strategies were partially reversed . At 24 months from EOT , spine BMD increased by 1.53 % ( 95 % CI 0.63-2.43 ; p = 0.001 ) after stopping exemestane and fell by 1.93 % ( 95 % CI -2.91 to 0.95 ; p = 0.0002 ) following tamoxifen withdrawal . A similar pattern of changes was observed at the hip . At 2 years post EOT , BMD changes from baseline were similar with both treatment strategies . Corresponding inverse changes in BTM were seen , with an increase following tamoxifen withdrawal and a reduction after exemestane . A higher number of fractures occurred during exemestane treatment , but fracture rates were similar after treatment withdrawal . With the switch strategy used in IES , the on treatment adverse bone effects of exemestane are reversed . Ongoing monitoring of BMD is therefore not routinely required .
{"Intervention": ["exemestane", "tamoxifen", "aromatase inhibitors", "endocrine treatment"], "Outcome": ["effects", "fracture rates", "adverse bone effects", "number of fractures occurred", "inverse changes in BTM", "spine BMD", "BMD changes"], "Participant": ["206", "4,724"]}