Given an abstract from a research paper, your task is to identify and label relationships between chemical compounds and genes mentioned in the abstract.

The relationship type must be one of ['DOWNREGULATOR', 'SUBSTRATE', 'INDIRECT-REGULATOR', 'PART-OF', 'MODULATOR-ACTIVATOR', 'REGULATOR', 'INHIBITOR', 'COFACTOR', 'UPREGULATOR', 'ACTIVATOR', 'ANTAGONIST', 'NOT', 'INDIRECT-DOWNREGULATOR', 'SUBSTRATE_PRODUCT-OF', 'INDIRECT-UPREGULATOR', 'AGONIST', 'PRODUCT-OF', 'MODULATOR', 'DIRECT-REGULATOR', 'UNDEFINED', 'AGONIST-INHIBITOR', 'AGONIST-ACTIVATOR', 'MODULATOR-INHIBITOR'].

Please format your output as a JSON array. Each entry in the array should express a single relation, formatted as ["<Entity_A>", "<RELATION_A_B>", "<Entity_B>"]. If no relations can be found, please output an empty JSON array [].

Abstract:

tert-Butylcarbamate-Containing Histone Deacetylase Inhibitors: Apoptosis Induction, Cytodifferentiation, and Antiproliferative Activities in Cancer Cells. Herein we report novel pyrrole- and benzene-based hydroxamates (8, 10) and 2'-aminoanilides (9, 11) bearing the tert-butylcarbamate group at the CAP moiety as histone deacetylase (HDAC) inhibitors. Compounds 8   b and 10   c selectively inhibited HDAC6 at the nanomolar level, whereas the other hydroxamates effected an increase in acetyl-α-tubulin levels in human acute myeloid leukemia U937 cells. In the same cell line, compounds 8   b and 10   c elicited 18.4 and 21.4% apoptosis, respectively (SAHA: 16.9%), and the pyrrole anilide 9   c displayed the highest cytodifferentiating effect (90.9%). In tests against a wide range of various cancer cell lines to determine its antiproliferative effects, compound 10   c exhibited growth inhibition from sub-micromolar (neuroblastoma LAN-5 and SH-SY5Y cells, chronic myeloid leukemia K562 cells) to low-micromolar (lung H1299 and A549, colon HCT116 and HT29 cancer cells) concentrations. In HT29 cells, 10   c increased histone H3 acetylation, and decreased the colony-forming potential of the cancer cells by up to 60%.
[["tert-butylcarbamate", "INHIBITOR", "histone deacetylase"], ["hydroxamates", "INHIBITOR", "histone deacetylase"], ["2\u0027-aminoanilides", "INHIBITOR", "HDAC"], ["2\u0027-aminoanilides", "INHIBITOR", "histone deacetylase"], ["tert-butylcarbamate", "INHIBITOR", "HDAC"], ["hydroxamates", "INHIBITOR", "HDAC"], ["hydroxamates", "INDIRECT-UPREGULATOR", "acetyl-\u03b1-tubulin"]]