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Paper text:
according to the world drug report 2011 , drug abuse especially use of opium is a major health problem in iran , because it causes the death of about 91 persons in one million 1564 year old iranian people . in 2009 ,
opium addiction was the primary diagnosis for nearly 83% of iranian clients seeking treatment programs ( 1 ) .
estimates show that at least 1.2 million people in iran are dependent to drug ( 2 ) .
this huge number of drug users apparently should receive appropriate treatment programs . in terms of the public health approach to the problem
thus , harm reduction with a focus on methadone maintenance treatment as an effective treatment for opioid would become a priority ( 3 ) . however , retention time in some treatment program is not favorable ( 4 ) . in a study ,
the average relapse rate during six months after treatment admission in maragheh ( iran ) was 64% indicating the necessity for developing complementary relapse prevention treatments ( rpt ) ( 5 ) .
the relapse prevention proposed by marlatt and gordon based on cognitive - behavioral treatment is an influential treatment programs for drug dependence ( 6 ) . in this treatment approach , after identifying high risk situations leading to drug use and relapse , appropriate interventions are designed and prepared by therapists .
this educational treatment improves efficacy of the mmt program because it provides patients with an opportunity to develop skills and strategies that help them coping effectively with high risk situations related to drug use and realize and manage relapse warning signs ( 7 ) .
the purpose of this paper is to evaluate the effectiveness of a relapse prevention cognitive - behavioral model , based on marlatt approach in the treatment of individuals with opioid use disorder participating in mmt program at the outpatient clinic of the iranian national center for addiction studies ( incas ) .
as the study was an interventional study , a sample of 92 total patients participating in mmt program at incas was randomly allocated to either 
also , a written consent was given to all participants prior to participating in the study .
the inclusion criteria consisted of participating on mmt for at least one month and not suffering from serious physical or mental illnesses such as active suicidal or homicidal ideation , frank delusions or overt aggressive and threatening behaviors .
however , since most of the clients were male , we recruited only male clients to our study for the sake of statistical purposes .
relapse criteria were defined as not showing - up for mmt , confirmation of return to drug use for at least five continuous days and positive urinary morphine test ( random urine testing was a rule at the clinic ) . however , there were patients who had discontinued their program due to other reasons such as moving to another clinic or program .
socio - demographic information , history of drug taking , treatment history , as well as some high risk behaviors related to addiction were collected through a short questionnaire . besides , farsi version of idts was used to identify high risk situations resulting in drug use and drug relapse .
the questionnaire covers 8 types of drug taking situations including unpleasant emotions ( ten items ) , physical discomfort ( five items ) , pleasant emotions ( five items ) , testing personal control ( five items ) , urges and temptations to use ( five items ) , conflict with others ( ten items ) , social pressure to use ( five items ) , and pleasant times with others ( five items ) .
the scoring ranges were from 0 to3 , i.e. never , rarely , frequently , and almost always , respectively ( 8) . in order to prevent responses under the influence of drugs or drug withdrawal that could result in suspected unreliability and invalidity , we applied the one month delay rule for recruiting on intervention program . further , r to evaluate clients confidence levels across high risk situations , the drug taking confidence questionnaire ( dtcq-8 ) was utilized ( 9 ) . to assess the influence of intervention on relapse in both the intervention and control group , the mantel haenszel statistical test was used
this test is used because the effect of the intervention variable on relapse is influenced by covariates that can be controlled .
also , the probability of relapse in that regression was modeled as a binary response ( 1=relapse , 0=no relapse ) in a linear logistic regression to determine the predictors of relapse .
it was based on a logic model because we evaluated high risk situations for each patient .
both one therapist and one facilitator involved in the intervention were trained for at least 10 hours . in each session ,
one of the researchers was used to inspect the therapists work according to the group therapy checklist .
each session , which lasted 90 minutes , was dedicated to a specific topic including introduce intervention and members of group , managing emotions , thought of using substances , craving and urge as well as social pressure for drug use , relapse , anger , in addition to refusal skills problem solving , communication skills and building a recovery support system .
in addition , at the end of each session , patients were given a reminder sheet that outlined the elements of the session topic and relevant skills . also , they did some homework .
as improvement of self - efficacy is a major component of rpt ( 9 ) , specific attention to this topic was made in almost every session .
self - presentation of success case stories by clients from outside the group as social modeling was part of the practice .
it was based on a logic model because we evaluated high risk situations for each patient .
both one therapist and one facilitator involved in the intervention were trained for at least 10 hours . in each session ,
one of the researchers was used to inspect the therapists work according to the group therapy checklist .
each session , which lasted 90 minutes , was dedicated to a specific topic including introduce intervention and members of group , managing emotions , thought of using substances , craving and urge as well as social pressure for drug use , relapse , anger , in addition to refusal skills problem solving , communication skills and building a recovery support system .
in addition , at the end of each session , patients were given a reminder sheet that outlined the elements of the session topic and relevant skills . also , they did some homework .
as improvement of self - efficacy is a major component of rpt ( 9 ) , specific attention to this topic was made in almost every session .
self - presentation of success case stories by clients from outside the group as social modeling was part of the practice .
about 59% of patients had some drug injection experience prior to recruitment in the treatment program .
the mean drug use span among participants was 14.2 ( sd=9.4 ) years and the average age of starting addiction was 21.86 ( sd=7.1 ) years old .
this means that there is no difference between those variables for intervention influence on relapse risk probability ( p0/05 ) .
the effect of some variables including level of education , employment status , marital status , self efficacy , social support , and alcohol were heterogeneous . 

the odd ratio of the variable of intervention program in 30 days , 90 days , and 195 days after the intervention , ( i.e. the follow - up period ) were 0.48 , 0.31 , and 0.13 respectively .
this revealed that on average , the probability of relapse among individuals in the intervention group was lower than patients in control group ( table 1 ) .
result of logistic regression for the impact of intervention probability of relapse among illiterate patients , ones with primary and secondary education , were respectively about 1.03 and 2.12 times more than those that had at least a diploma and higher .
relapse risk for unemployed participants was 3.97 times more than people in full - time jobs .
additionally , risks of relapse among participants who were single and married were about 1.36 and 1.76 times more than divorced and speared ones .
furthermore , depriving from social support increased risk of relapse among patient about 1.98 times .
moreover , risk of relapse for participants not having enough self - efficacy as well as those with low self - efficacy were respectively around 3.93 and 3.05 times more than that of enough or high self - efficacy .
besides , the probability of relapse among patients that consumed alcohol was nearly 1.48 less than others ( table 2 ) .
this study was designed to evaluate the effect of cbt - based relapse prevention on patients already on mmt . according to our findings , the role of the cognitive  behavioral treatment program is genuinely effective because this relapse prevention program resulted in longer retention on mmt .
this result is consistent with some published studies showing that rpt is a successful approach to reduce substance use and to be particularly effective in maintaining on retention program over long term follow up periods ( 1215 ) .
longer retention on mmt provides harm reduction benefits , including social and physical health , and quality of life in patients .
higher level of self efficacy was an indicator for better retention on treatment in our study .
while more studies are in conformity with our findings ( 1619 ) , the relationship between self - efficacy and improved outcomes is ambiguous in other studies ( 20 ) . as indicated elsewhere , we put a greater emphasis on self - efficacy in our trial by continuing the topic in consecutive sessions and by presenting successful patients as role models to our clients .
the risk of relapse was higher for patients with lower levels of education as compared to the group with higher education levels .
this finding supported some previous research that had concluded low education levels had been associated with poor treatment outcome ( 2124 ) .
as skills training was a core segment of our intervention , clients with lower education might have found it more difficult to participate in the training and assimilated less of the material .
this foreseeable result is compatible with various previous studies ( 2527 ) . yet , our finding is in contrast with other studies proposing that being employed had a negative correlation with retention in treatment ( 2830 ) .
contrary to some of the findings reported in the literature , probability of relapse was higher among single and married patients as compared with separated or divorced individuals within the present study .
this finding is in contrast with many former studies that have shown better treatment outcome for married individuals ( 3032 ) .
one explanation for this finding is that married and single patients may have some difficulties in relationships with family members because of drug abuse resulting in obtaining lower support ; therefore , they are more subject to relapse during treatment . in the present study , significantly a lower level of social support
this finding confirmed that social support plays an effectual role in longer treatment time that is consistent with other studies ( 3338 ) .
another study indicated that deprivation from social support at the start of treatment could hinder completion of the 21-day treatment program ( 39 ) .
our finding is in contrast to some other studies that failed to confirm social support as a predictor for successful treatment .
one study showed that stronger connections to family before treatment had a negative effect on the treatment result ( 40 ) .
a rather unexpected result , however , was the negative correlation between alcohol consumption and the risk of relapse .
some earlier studies demonstrated a negative correlation between alcohol use and retention time ( 4142 ) .
one study demonstrated that use of alcohol was not related to relapse ( 43 ) .
one conjecture claims that alcohol use may be justified as an alternative to reduce cravings and drug use .
we conducted this study among patients attending in incas and these findings can not be extrapolated to all opioid - dependent patients .
first , this study applied rpt based on the crustal roots of drug use among patients .
secondly , patients were followed - up for a long time to determine the effect of training intervention more accurately .
our study demonstrated relapse prevention treatment has a significant role in decreasing relapse among opioid 
, this study advocates serious focus on increases in social support and self - efficacy . this is beneficial not only in terms of health cognitive - behavior change , but also perception of social support associated with behavior change .
we suggest relapse prevention services can be introduced as a complementary therapy , facilitating more successful treatments in mmt programs .
ethical issues ( including plagiarism , informed consent , misconduct , data fabrication and/or falsification , double publication and/or submission , redundancy , etc ) have been completely observed by the authors .
background : to evaluate the effectiveness of a relapse prevention cognitive - behavioral model , based on marlatt treatment approach , in opioid - dependent patients participating in the methadone maintenance treatment ( mmt ) in iran.methods:the study consisted of 92 individuals treated with methadone in iranian national center of addiction studies ( incas ) . 
 participants were randomized into two groups : educational intervention group ( n=46 ) and control group ( n=46 ) . 
 the intervention was comprised of 10 weekly 90 minute sessions , done during a period of 2.5 months based on the most high risk situations determined using inventory drug taking situation instrument . 
 relapse was defined as not showing up for mmt , drug use for at least 5 continuous days , and a positive urinary morphine test.results:while , only 36.4% of the intervention group relapsed into drug use , 63.6% of the control group relapsed . 
 the result of the logistic regressions showed that the odd ratio of the variable of intervention program for the entire follow up period was 0.43 ( p<0.01 ) . 
 further , the odd ratio of this variable in one month , three months , and 195 days after the therapy were 0.48 ( p<.03 ) , 0.31 ( p<.02 ) , and 0.13 ( p<.02 ) respectively that revealed that on average , the probability of relapse among individuals in the intervention group was lower than patients in control groupconclusion : relapse prevention model based on marlatt treatment approach has an effective role in decreasing relapse rate . 
 this model can be introduced as a complementary therapy in patients treated with methadone maintenance .