Given an abstract from a research paper, your task is to identify and label relationships between chemical compounds and genes mentioned in the abstract.

The relationship type must be one of ['DOWNREGULATOR', 'SUBSTRATE', 'INDIRECT-REGULATOR', 'PART-OF', 'MODULATOR-ACTIVATOR', 'REGULATOR', 'INHIBITOR', 'COFACTOR', 'UPREGULATOR', 'ACTIVATOR', 'ANTAGONIST', 'NOT', 'INDIRECT-DOWNREGULATOR', 'SUBSTRATE_PRODUCT-OF', 'INDIRECT-UPREGULATOR', 'AGONIST', 'PRODUCT-OF', 'MODULATOR', 'DIRECT-REGULATOR', 'UNDEFINED', 'AGONIST-INHIBITOR', 'AGONIST-ACTIVATOR', 'MODULATOR-INHIBITOR'].

Please format your output as a JSON array. Each entry in the array should express a single relation, formatted as ["<Entity_A>", "<RELATION_A_B>", "<Entity_B>"]. If no relations can be found, please output an empty JSON array [].

Abstract:

Effectors of the activation of human [Glu1]plasminogen by human tissue plasminogen activator. The activation of human [Glu1]plasminogen [ (Glu1]Pg) by human recombinant (rec) two-chain tissue plasminogen activator (t-PA) is inhibited by Cl-, at physiological concentrations, and stimulated by epsilon-aminocaproic acid (EACA), as well as fibrin (ogen). Chloride functions as a result of its binding to [Glu1]Pg, with a Ki of approximately 9.0 mM, thereby rendering [Glu1]Pg a less effective substrate for two-chain rec-t-PA. EACA stimulates the activation in Cl- (-) containing solutions, with a Ka of approximately 4.0 mM, primarily by reversal of the Cl- (-) inhibitory effect. Fibrinogen appears to exert its stimulatory properties mainly through effects on the enzyme, two-chain rec-t-PA, with a Ka of approximately 3.7 microM in activation systems containing physiological levels of Cl-. Analysis of the results of this paper reveals that normal plasma components, Cl- and fibrinogen, exert major regulatory roles on the ability of [Glu1]Pg to be activated by two-chain rec-t-PA, in in vitro systems. The presence of Cl- inhibits the stimulation of [Glu1]Pg activation that would normally occur in the presence of fibrinogen, a result of possible importance to the observation that some degree of systemic fibrinogenolysis accompanies therapeutic use of tissue plasminogen activator.
[["epsilon-aminocaproic acid", "ACTIVATOR", "(Glu1]Pg"], ["EACA", "ACTIVATOR", "human [Glu1]plasminogen"], ["Cl-", "INHIBITOR", "human [Glu1]plasminogen"], ["Cl-", "INHIBITOR", "(Glu1]Pg"], ["Cl-", "INHIBITOR", "tissue plasminogen activator"], ["Chloride", "DIRECT-REGULATOR", "[Glu1]Pg"], ["Cl-", "INHIBITOR", "[Glu1]Pg"], ["EACA", "ACTIVATOR", "t-PA"], ["EACA", "ACTIVATOR", "tissue plasminogen activator"], ["EACA", "ACTIVATOR", "(Glu1]Pg"], ["epsilon-aminocaproic acid", "ACTIVATOR", "tissue plasminogen activator"], ["Cl-", "INHIBITOR", "t-PA"], ["Cl-", "REGULATOR", "[Glu1]Pg"], ["epsilon-aminocaproic acid", "ACTIVATOR", "t-PA"], ["epsilon-aminocaproic acid", "ACTIVATOR", "human [Glu1]plasminogen"]]