You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["Outcome", "Participant", "Intervention"].

Please return the output as a JSON object of the format: {"Participant" : ["patients with COPD", ...], "Intervention" : ["Atenolol", ...], "Outcome" : ["blood pressure", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Variability of thrombolytic coronary reperfusion : an angiographic study of streptokinase and anistreplase . A total of 1,615 angiographic readings in 240 patients with acute myocardial infarction were analyzed from a randomized trial of intravenous anistreplase ( Eminase ) , also known as anisoylated plasminogen streptokinase activator complex ( APSAC ) , versus intracoronary streptokinase . Coronary arteriography was performed at baseline and at 15 , 30 , 45 , 60 , 75 , and 90 minutes after drug infusion . Coronary flow in the infarct-related artery was defined using the TIMI criteria . Some serial change in perfusion was noted in 25 % of the total patient population and in 49 % of all reperfusion patients . Complete loss of perfusion ( grade 2 or 3 to grade 0 or 1 ) occurred in 35 % of all reperfused patients . Half of these patients ultimately developed complete loss of perfusion at the study endpoint . All of these changes in flow were statistically more common for the circumflex coronary artery and early treatment ( less than 4 h ) , but did not differ for anistreplase or streptokinase . We conclude that frequent alterations in coronary blood flow occur early during reperfusion therapy and that these findings may explain reports with varying results of thrombolytic therapy . Any angiographic assessment of thrombolytic drug efficacy should take these variations as well as interobserver variability into account .
{"Intervention": ["intravenous anistreplase ( Eminase ) , also known as anisoylated plasminogen streptokinase activator complex ( APSAC )", "reperfusion therapy", "thrombolytic coronary reperfusion", "thrombolytic therapy", "anistreplase", "streptokinase", "thrombolytic drug"], "Outcome": ["Complete loss of perfusion", "loss of perfusion", "alterations in coronary blood flow", "serial change in perfusion"], "Participant": ["240", "acute myocardial infarction"]}