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the north american association of central cancer registries reported in the period from 1992 to 1997 more than 1.6 million females with the diagnosis of cancer . of these , 67,746 were ovarian cancers , 1563 ( or 2.3% ) of which occurred in patients younger than 25 .
close to 50% ( 780 cases ) were reported in women aged 20 to 24 , 481 cases in the 15- to 19-year - old group , and 302 cases in the neonates to the 14-year - old group.1 the three major types of ovarian tumors are epithelial , sex cord , and germ cell .
epithelial cell tumors represent the majority of all ovarian neoplasms ( 82%).conversely , germ cell tumors ( gcts ) are rare , comprising approximately 20% of all ovarian tumors , both benign and malignant .
the most commonly occurring gct is the dysgerminoma , which accounts for only 1 - 5% of all ovarian cancers.26 in the literature search using pubmed , midline search and google , some reports on the incidence of dysgerminoma in families were found .
i am presenting two cases of dysgerminomas diagnosed in two sisters aged 14 and 19 years .
the first patient is a 14-year - old saudi single female who presented at the emergency department with a prolonged history of pelvic and lower abdominal swelling associated with a dull pelvic pain and anorexia .
physical examination revealed huge abdomenopelvic mass with mild tenderness over pelvis and lower abdomen . on inspection ,
the patient was referred for ultrasound examination and the study ( not shown ) revealed a large mass measuring 1216 cm arising from the right adnexa with upward extension into the abdomen .
ultrasound examination of the abdomen showed bilateral dilatation of pelvicalyceal system and upper ureters consistent with bilateral hydrouretro - nephrosis .
magnetic resonance imaging ( mri ) of the pelvis ( figure 1 ) showed a large encapsulated mass arising from right adnexa with upward extension into abdominal cavity displacing and compressing both uterus and urinary bladder anteriorly and inferiorly .
the mass was non - homogeneous with predominantly intermediate signal intensity in proton density images , and contained multiple cystic spaces representing previous tumor hemorrhage .
two consequent saggital proton density mri of the pelvis showing a large mass arising from adnexa with upward extension into abdominal cavity .
the mass appears of intermediate signal intensity with multiple internal foci of high signal intensity .
mass effect on adjacent structures such as the uterus , urinary bladder and rectum is seen .
intravenous urography ( figure 2 ) showed bilateral laterally displaced and dilated ureters with bilateral hydronephrosis .
single film of ivp series showing lateral deviation of both pelvic ureters by a large pelvic mass with bilateral hydronephrosis .
the patient was operated on and the treatment consisted of simple right salpingo - oophorectomy followed by adjuvant radiotherapy and chemotherapy .
examination of the surgical specimen revealed pure dysgerminoma ( stage one a ) arising from the right ovary .
the follow - up of thirty months confirmed that the patient was in good health with normal ultrasound and laboratory results .
two years later , her sister presented at the age of 19 with lower abdominal mass , mild pain and dysmenorrhea .
physical examination showed a palpable mass in the lower abdomen and pelvis with mild tenderness .
the patient was referred to the radiology department where ultrasound , computerized tomography ( ct ) scan ( figures 3 and 4 ) and mri were done .
the imaging features of the mass were almost the same as in the first patient .
the patient was operated on and the mass was found to have arisen from the left ovary with no macroscopic invasion of surrounding structures .
two consequent contrast enhanced axial ct scan images of the pelvis showing irregular heterogeneously enhancing mass arising from left adnexa with upward extension .
two sagittally reconstructed ct scan images showing a large mass arising from the pelvis , displacing the urinary bladder and uterus anteriorly and inferiorly .
the mass appears isodense to the muscles and contains multiple areas of low densities representing cystic changes .
patients present with a unilateral , predominantly solid mass with varying degrees of necrosis and hemorrhage .
the patients are treated with unilateral salpingo - oophorectomy and chemotherapy.78 dysgerminomas are bilateral in 10 - 35% of cases .
they may have a 46xy karyotype with pure gonadal dysgenesis or androgen insensitivity syndrome , or they may have a 45x , 46xy karyotype with mixed gonadal dysgenesis.910 in patients with a known or suspected adnexal mass , ultrasound is highly accurate in the assessment of the location of the tumor ( e.g. , differentiation of uterine from adnexal masses ) and in distinguishing between a benign and malignant adnexal lesion .
the optimal use of ultrasound requires the analysis of morphologic features and doppler findings.1114 ovarian masses with septations greater than 3 mm , mural nodularity , and papillary projections suggest the diagnosis of malignant ovarian neoplasm.1517 the most significant feature is the presence of solid components within an ovarian mass,18 other features suggesting malignant etiology include vascular septations thicker than 3 mm , septal nodularity , and single or multiple enhancing solid components within a cystic mass.1920 necrosis within a solid lesion is also a strong indicator of malignancy . in our cases ,
many of these features such as solid components , central necrosis , heterogeneity , free fluid and central increased vscularity were present .
central color doppler flow within solid components of an ovarian mass has been shown to be an accurate predictor of malignancy.182122 brown and colleagues18 studied 211 adnexal masses , including 28 malignancies to determine the best discrimination between benignity and malignancy by gray - scale and doppler . a nonhyperechoic solid component within a mass , central blood flow on color doppler imaging , free intraperitoneal fluid , and septations within a mass had 93% sensitivity and 93% specificity for diagnosis of malignancy . in a setting of
sonographically indeterminate adnexal masses , mr imaging is used as a problem - solving tool .
the main advantage of mr imaging is that it can provide tissue characterization based on signal properties.23 for adequate evaluation of adnexal masses on mr imaging , t1-weighted and t2- weighted images are fundamental in the delineation of pelvic anatomy and tumor .
gadolinium - enhanced t1-weighted images help to characterize the internal architecture of cystic lesions and improve the detection of solid components.2425 mr imaging has been shown to be superior to doppler ultrasound and conventional ct in the diagnosis of malignant ovarian masses [ the estimated area under receiver operating characteristic curve ( auc ) was 0.78 for ultrasound , 0.87 for ct , and 0.91 for mr imaging].26 although ct has not traditionally been used in the characterization of an adnexal mass , studies have shown that the utility of thin - section multislice ct is equivalent to that of ultrasound .
ct characterization of adnexal mass relies on the depiction of morphologic features of enhancing mural nodularity or heterogeneity and necrosis within a solid lesion .
ancillary findings , such as ascites and peritoneal carcinomatosis on ultrasound , ct , or mr imaging are strong indicators of a malignant etiology for an adnexal mass . several cases of families with both males and females diagnosed with germ cell cancers have been documented .
the low incidence of ovarian germ cell cancers suggests that multiple occurrences in the same family may not be due to chance .
rather , it is possible that a gene that confers susceptibility to ovarian germ cell cancers , and possibly to germ cell tumors in males as well , is present in at least some of these families.27 the primary goal of radiologic assessment is the differentiation of malignant tumors from benign tumors , rather than determination of histologic subtype . sometimes , it is possible , however , to suggest the histologic subtype of an epithelial neoplasm based on particular imaging features .
i would like , in conclusion , to recommend an early diagnosis . with the availability of recent imaging techniques ,
a full radiological investigation could be done to search for metastasis , evaluate the adjacent organs , and give an early referral to the oncology center since the tumor is chemo - sensitive .
although rare , dysgerminomas are important irrespective of incidence because they affect women of reproductive age ( i.e. , < 45 years ) . 
 dysgerminomas make up two thirds of all malignant ovarian neoplasms in women younger than 20 years . 
 all dysgerminomas are considered malignant , but only one third of dysgerminomas behave aggressively . 
 their exact etiology has not been determined . 
 few reports are found in the review of the literature on the incidence of dysgerminoma and other germ cell tumors in families . 
 some of these reports focus on the genetic abnormalities associated with germ cell tumor and the responsible gene . 
 two cases of dysgerminomas diagnosed in two sisters aged 14 and 19 years old are presented here with their radiological studies .