You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["Outcome", "Participant", "Intervention"].

Please return the output as a JSON object of the format: {"Participant" : ["patients with COPD", ...], "Intervention" : ["Atenolol", ...], "Outcome" : ["blood pressure", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Four-year outcomes from adolescent alcohol and drug treatment . OBJECTIVE Knowledge of treatment response for alcohol and drug problems among adults is mounting ; less is known about long-term outcome for adolescents who receive treatment for alcohol and drug problems . The current study examined youth substance involvement over 4 years ( using five waves of data collection ) following treatment for alcohol and drug abuse . METHOD A cohort of youth ( N = 162 , 60 % male ) treated during adolescence ( mean age = 16 years ) was followed into young adulthood , a period associated with stabilization of alcohol use patterns and elevated risk for life problems secondary to both alcohol and drug use . Participants ( 14-18 years old ) were consecutive admissions to inpatient adolescent alcohol and drug treatment centers in San Diego that were abstinence focused and based on the 12-step approach . RESULTS Alcohol and other drug use were reduced during the 4 years posttreatment , with the exception of nicotine . The greatest prevalence reduction occurred for stimulants ; modest changes were evident in alcohol and marijuana use . Nicotine was the most commonly used substance throughout the 4 years after treatment . Several distinct substance involvement trajectories were evident during the 4 years following treatment . CONCLUSIONS Alcohol and drug use patterns during the 4 years following treatment highlight both changes and diversity in substance involvement as youth make the transitions from middle to late adolescence and into young adulthood . Findings demonstrate the importance of identifying transitional periods and the need for alternative intervention strategies that may help the progression of this population into young adulthood .
{"Intervention": ["treatment for alcohol and drug abuse", "adolescent alcohol and drug treatment", "treatment for alcohol and drug problems"], "Outcome": ["Alcohol and other drug use", "prevalence reduction"], "Participant": ["adolescence", "alcohol and drug problems", "14-18 years old", "16 years )", "youth", "adolescent", "162", "young adulthood", "adolescents"]}