You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["Outcome", "Participant", "Intervention"].

Please return the output as a JSON object of the format: {"Participant" : ["patients with COPD", ...], "Intervention" : ["Atenolol", ...], "Outcome" : ["blood pressure", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Comparison of different long-term asthma treatments in subjects with mild-to-moderate asthma . In order to compare the efficacy of different asthma treatment in subjects with mild-to-moderate asthma , three groups of 11 patients were treated with nedocromil sodium ( NS ) , beclomethasone dipropionate ( BDP ) and beclomethasone dipropionate plus salmeterol ( BDP + S ) in an open , randomized study . Symptom score , peak expiratory flow ( PEF ) maximal amplitude , forced expiratory volume in one second ( FEV1 ) , and methacholine reactivity were measured at the baseline and at intervals of 3 months up to 12 months . After 3 months , symptoms reduced significantly in all treatment groups , while PEF variability improved in BDP and BDP + S groups ; FEV1 and bronchial responsiveness to methacholine were significantly improved in comparison with baseline value in the BDP + S group only . No significant difference was observed after 6 and 12 months of treatment in PEF variability , FEV1 or bronchial hyperreactivity in the NS group compared with baseline values , while a significant difference was observed in symptom score . BDP group showed a significant improvement in FEV1 and bronchial reactivity to methacholine after 6 and 12 months of treatment . In the BDP + S group , the improvement in symptoms and pulmonary function persisted until the end of the study . In conclusion , the combination of beclomethasone dipropionate and salmeterol improved pulmonary function and bronchial reactivity earlier than beclomethasone dipropionate alone , while nedocromil sodium improved symptoms but not pulmonary function . Assuming that bronchial reactivity could be an indirect measurement of airway inflammation , overtreatment of asthma in relationship with the classification of asthma severity of the International Guidelines could improve both airway inflammation and the prognosis of airway obstruction .
{"Intervention": ["salmeterol", "beclomethasone dipropionate ( BDP )", "nedocromil sodium ( NS )", "beclomethasone dipropionate"], "Outcome": ["FEV1", "and", "bronchial reactivity", "symptoms", "pulmonary function", "PEF variability", "bronchial hyperreactivity"], "Participant": ["subjects with mild-to-moderate asthma .", "subjects with mild-to-moderate asthma , three groups of 11 patients"]}