You will be shown inclusion or exclusion criteria for a clinical trial. Given these criteria, your task is to extract all unique entities of the following types: ["Observation", "Condition", "Procedure", "Drug", "Temporal", "Multiplier", "Qualifier", "Negation", "ReferencePoint", "Scope", "Value", "Mood", "Device", "Visit", "Measurement", "Person"].

Please return the output as a JSON object of the format: {"Condition" : ["breast cancer", ...], "Device" : ["ports", ...], "Drug" : ["Atenolol", ...], "Measurement" : ["blood pressure", ...], "Mood" : ["suspected", ...], "Multiplier" : ["more than two", ...], "Negation" : ["no", ...], "Observation" : ["history", ...], "Person" : ["male", ...], "Procedure" : ["surgery", ...], "Qualifier" : ["severe", ...], "ReferencePoint" : ["enrollment", ...], "Scope" : ["infection", ...], "Temporal" : ["one day", ...], "Value" : ["50%", ...], "Visit" : ["ICU", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Subject must have a diagnosis of COPD based on the American Thoracic Society (ATS)/ European Respiratory Society (ERS) criteria. 
Male or female subjects, aged >=40 years. Females must be of Non Child Bearing Potential. The definition of Non Child Bearing Potential is as following: Females, regardless of their age, with functioning ovaries and who have a current documented tubal ligation or hysterectomy, or females who are post-menopausal. 
Have diagnosed COPD stage III or IV according to GOLD criteria: a baseline post-bronchodilator Forced Expiratory Volume, measured at 1 second (FEV1) <50% of predicted normal and a baseline post- bronchodilator FEV1/Inspiratory Vital Capacity (IVC) ratio <70%. 
Have experienced at least 2 moderate or severe COPD exacerbations leading to medical consultation (requiring oral corticosteroids or increasing dosage of oral corticosteroids and/or antibiotics or hospitalization) within the 12 months preceding Visit 1. 
Have stable COPD medication within 4 weeks prior to Visit 1 (no new medication added and no dosage changes in medication). 
Current or ex-smokers with a smoking history of at least 10 pack years (number of pack years = [number of cigarettes per day / 20] x number of years smoked, e.g., 20 cigarettes per day for 10 years, or 10 cigarettes per day for 20 years). 
Are currently managed at home (outpatients), are ambulatory and able to travel to the clinic. Subjects can be treated with all relevant COPD medication. This includes vaccines, inhaled short-acting beta-2-agonists as needed, short-acting or long-acting anticholinergics (tiotropium), systemic beta-2-agonists, theophylline, mucolytics, antioxidants, beta-1-agonists (for cardiovascular indication), non-invasive ventilation, long term oxygen therapy and can have Cor Pulmonale. 
A signed and dated written informed consent is obtained prior to participation. 
Able to comply with the requirements of the protocol and be available for study visits over 52 weeks.
{"Condition": ["functioning ovaries", "smokers", "hysterectomy", "ambulatory", "non-invasive ventilation", "COPD exacerbations", "tubal ligation", "cardiovascular indication", "Child Bearing Potential", "post-menopausal", "COPD", "Cor Pulmonale"], "Device": [], "Drug": ["beta-1-agonists", "vaccines", "antibiotics", "short-acting", "mucolytics", "systemic beta-2-agonists", "COPD medication", "tiotropium", "oxygen", "antioxidants", "oral corticosteroids", "theophylline", "long-acting anticholinergics", "inhaled short-acting beta-2-agonists"], "Measurement": ["FEV1/Inspiratory Vital Capacity (IVC) ratio", "American Thoracic Society (ATS)/ European Respiratory Society (ERS) criteria", "Forced Expiratory Volume, measured at 1 second (FEV1)", "smoking history", "GOLD criteria"], "Mood": [], "Multiplier": ["at least 2", "long term"], "Negation": ["Non", "ex"], "Observation": ["able to travel to the clinic", "written informed consent", "outpatients", "Able to comply with the requirements of the protocol", "managed at home", "available for study visits"], "Person": ["Male", "aged", "female", "females", "Females"], "Procedure": ["oxygen therapy", "managed"], "Qualifier": ["severe", "moderate", "increasing dosage", "stable"], "ReferencePoint": [], "Scope": ["moderate or severe", "Current or ex", "females who are post-menopausal", "Non Child Bearing Potential", "Females, regardless of their age, with functioning ovaries and who have a current documented tubal ligation or hysterectomy, or females who are post-menopausal", "number of pack years = [number of cigarettes per day / 20] x number of years smoked, e.g., 20 cigarettes per day for 10 years, or 10 cigarettes per day for 20 years", "oral corticosteroids or increasing dosage of oral corticosteroids and/or antibiotics or hospitalization", "COPD medication. This includes vaccines, inhaled short-acting beta-2-agonists as needed, short-acting or long-acting anticholinergics (tiotropium), systemic beta-2-agonists, theophylline, mucolytics, antioxidants", "Females, regardless of their age, with functioning ovaries and who have a current documented tubal ligation or hysterectomy"], "Temporal": ["Current", "prior to participation", "over 52 weeks", "within the 12 months preceding Visit 1", "post-bronchodilator", "post- bronchodilator", "within 4 weeks prior to Visit 1"], "Value": ["stage III or IV", "\u003e=40 years", "10 pack years", "\u003c50% of predicted normal", "\u003c70%"], "Visit": ["outpatients", "at home", "study visits", "hospitalization"]}