You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["HealthCareActivity", "InjuryOrPoisoning", "BodySubstance", "IntellectualProduct", "AnatomicalStructure", "SpatialConcept", "Chemical", "Bacterium", "MedicalDevice", "Organization", "BiomedicalOccupationOrDiscipline", "Finding", "BiologicFunction", "Virus", "ResearchActivity", "ClinicalAttribute", "PopulationGroup", "Eukaryote", "BodySystem", "Food", "ProfessionalOrOccupationalGroup"].

Please return the output as a JSON object of the format: {"Virus": ["HIV", ...], "Bacterium": ["MRSA", ...], "AnatomicalStructure": ["Lung", ...], "BodySystem": ["CNS", ...], "BodySubstance": ["Serum", ...], "Finding": ["Headache", ...], "InjuryOrPoisoning": ["Fracture", ...], "BiologicFunction": ["Death", ...], "HealthCareActivity": ["Biopsy", ...], "ResearchActivity": ["Clinical trial", ...], "MedicalDevice": ["Lenses", ...], "SpatialConcept": ["Camps", ...], "BiomedicalOccupationOrDiscipline": ["Forensic medicine", ...], "Organization": ["WHO", ...], "ProfessionalOrOccupationalGroup": ["Provider", ...], "PopulationGroup": ["Swimmers", ...], "Chemical": ["Gold", ...], "Food": ["Rice", ...], "IntellectualProduct": ["RPAM", ...], "ClinicalAttribute": ["Biomarker", ...], "Eukaryote": ["Dogs", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Peptide -Mediated Interference of PB2 - eIF4G1 Interaction Inhibits Influenza A Viruses ' Replication in Vitro and in Vivo Influenza viruses are obligate parasites that hijack the host cellular system. Previous results have shown that the influenza virus PB2 subunit confers a dependence of host eukaryotic translation initiation factor 4-γ 1 (eIF4G1) for viral mRNA translation. Here, we demonstrated that peptide -mediated interference of the PB2 - eIF4G1 interaction inhibited virus replication in vitro and in vivo. Remarkably, intranasal administration of the peptide provided 100% protection against lethal challenges of influenza A viruses in BALB/c mice, including H1N1, H5N1, and H7N9 influenza virus subtypes. Mapping of the PB2 protein indicated that the eIF4G1 binding sites resided within the PB2 cap - binding domain. Virtual docking analysis suggested that the inhibitory peptide associated with the conserved amino acid residues that were essential to PB2 cap-binding activity. Overall, our results identified the PB2 - eIF4G1 interactive site as a druggable target for influenza therapeutics.
{"AnatomicalStructure": [], "Bacterium": [], "BiologicFunction": ["Replication", "hijack the host cellular system", "virus replication", "Interaction", "binding domain", "influenza", "viral mRNA translation", "interaction"], "BiomedicalOccupationOrDiscipline": [], "BodySubstance": [], "BodySystem": [], "Chemical": ["amino acid residues", "influenza virus PB2", "PB2", "peptide", "druggable", "eIF4G1", "Peptide", "PB2 protein", "PB2 cap", "interactive site", "binding sites", "host eukaryotic translation initiation factor 4-\u03b3 1"], "ClinicalAttribute": [], "Eukaryote": ["obligate parasites", "BALB/c mice"], "Finding": ["lethal"], "Food": [], "HealthCareActivity": ["therapeutics", "cap-binding activity", "intranasal administration", "challenges"], "InjuryOrPoisoning": [], "IntellectualProduct": ["Virtual docking analysis"], "MedicalDevice": [], "Organization": [], "PopulationGroup": [], "ProfessionalOrOccupationalGroup": [], "ResearchActivity": ["Mapping"], "SpatialConcept": [], "Virus": ["H1N1", "Influenza viruses", "Influenza A Viruses", "H5N1", "H7N9 influenza virus subtypes", "influenza A viruses"]}