You will be shown inclusion or exclusion criteria for a clinical trial. Given these criteria, your task is to extract all unique entities of the following types: ["Observation", "Condition", "Procedure", "Drug", "Temporal", "Multiplier", "Qualifier", "Negation", "ReferencePoint", "Scope", "Value", "Mood", "Device", "Visit", "Measurement", "Person"].

Please return the output as a JSON object of the format: {"Condition" : ["breast cancer", ...], "Device" : ["ports", ...], "Drug" : ["Atenolol", ...], "Measurement" : ["blood pressure", ...], "Mood" : ["suspected", ...], "Multiplier" : ["more than two", ...], "Negation" : ["no", ...], "Observation" : ["history", ...], "Person" : ["male", ...], "Procedure" : ["surgery", ...], "Qualifier" : ["severe", ...], "ReferencePoint" : ["enrollment", ...], "Scope" : ["infection", ...], "Temporal" : ["one day", ...], "Value" : ["50%", ...], "Visit" : ["ICU", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

1. Males and females age ≥18 years in second relapse or refractory. 
2. Males and females age ≥60 years in first relapse or refractory. 
3. Must have baseline bone marrow sample taken. 
4. Morphologically documented primary AML or AML secondary to myelodysplastic syndrome (MDS with ≥20% bone marrow or peripheral blasts), as defined by the World Health Organization (WHO) criteria, confirmed by pathology review at treating institution. 
5. Able to swallow the liquid study drug. 
6. ECOG performance status of 0 to 2 
7. In the absence of rapidly progressing disease, the interval from prior treatment to time of AC220 administration will be at least 2 weeks for cytotoxic agents or at least 5 half-lives for noncytotoxic agents. The use of chemotherapeutic or antileukemic agents other than hydroxyurea is not permitted during the study with the possible exception of intrathecal (IT) therapy at the discretion of the Investigator and with the agreement of the Sponsor. 
8. Persistent chronic clinically significant non-hematological toxicities from prior treatment must be ≤Grade 1. 
9. Prior therapy with FLT3 inhibitors is permitted, except previous treatment with AC220. 
10. Serum creatinine ≤1.5 × ULN and glomerular filtration rate (GFR) > 30 mL/min 
11. Serum potassium, magnesium, and calcium levels should be at least within institutional normal limits. 
12. Total serum bilirubin ≤1.5 × ULN 
13. Serum aspartate transaminase (AST) and/or alanine transaminase (ALT) ≤2.5 × ULN 
14. Females of childbearing potential must have a negative pregnancy test (urine β-hCG). 
15. Females of childbearing potential and sexually mature males must agree to use a medically accepted method of contraception throughout the study. 
16. Written informed consent must be provided.
{"Condition": ["myelodysplastic syndrome", "AML", "refractory", "childbearing potential", "MDS", "relapse", "toxicities"], "Device": [], "Drug": ["FLT3 inhibitors", "AC220"], "Measurement": ["bone marrow", "peripheral blasts", "alanine transaminase (ALT)", "Serum creatinine", "Serum calcium", "Total serum bilirubin", "Serum potassium", "glomerular filtration rate (GFR)", "pregnancy test", "ECOG performance status", "Serum aspartate transaminase (AST)", "Serum magnesium"], "Mood": ["permitted"], "Multiplier": ["first", "second"], "Negation": ["except"], "Observation": [], "Person": ["Females", "age", "females", "Males"], "Procedure": ["World Health Organization (WHO) criteria", "treatment", "pathology review", "urine \u03b2-hCG", "bone marrow sample", "therapy"], "Qualifier": ["from prior treatment", "Morphologically documented", "clinically significant", "\u2264Grade 1", "non-hematological", "primary"], "ReferencePoint": [], "Scope": ["Serum potassium, magnesium, and calcium", "relapse or refractory", "Females of childbearing potential", "bone marrow or peripheral blasts"], "Temporal": ["prior", "baseline"], "Value": ["\u22642.5 \u00d7 ULN", "\u003e 30 mL/min", "negative", "\u226518 years", "\u22641.5 \u00d7 ULN", "at least within institutional normal limits", "\u2264Grade 1", "\u226560 years", "0 to 2", "\u226520%"], "Visit": []}