You will be shown the abstract of a medical clinical trial report. Your task is to extract all the findings from this report into a JSON array. Each finding should contain the following five elements:

- Intervention: The medical intervention being tested. This should be a text span copied from the input passage.
- Comparator: The baseline against which the intervention is being evaluated. This should be a text span copied from the input passage. If no comparator is reported, set to `null`.
- Outcome: The medical outcome whose effect is being measured. This should be a text span copied from the input passage.
- Effect: The effect of the intervention on the outcome, relative to the comparator. The effect should be one of the following three values: ("significantly increased", "significantly decreased", "no significant difference").
- Evidence: The evidence for the effect. This should be a text span copied from the input passage.

Please format your output as a JSON array. Each entry in the output should be an array containing the 5 elements listed above, in the following order: [<intervention>, <comparator>, <outcome>, <effect>, <evidence>].

For example, an output with two findings might read:
```
[["aspirin", "placebo", "headache severity", "significantly decreased", "Mean headache severity was significantly decreased in the aspirin group compared to the placebo group (p < 0.05)."], ["aspirin", "placebo", "weight loss", "no significant difference", "We did not observe any difference in weight loss between the group given aspirin relative to the control group"]]
```

There are 3 finding(s) in the abstract below. Please extract them. Output only the JSON array with these 3 findings. Do not include any additional text.

Abstract:
ABSTRACT.BACKGROUND: Liposome bupivacaine is a novel formulation of the local anesthetic bupivacaine, designed to provide prolonged postsurgical analgesia. This analysis examined pooled efficacy data as reflected in cumulative pain scores from 10 randomized, double-blind liposome bupivacaine clinical studies in which the study drug was administered via local wound infiltration.

ABSTRACT.METHODS: A total of 823 patients were exposed to liposome bupivacaine in 10 local wound infiltration studies at doses ranging from 66 mg to 532 mg in five surgical settings; 446 patients received bupivacaine HCl (dose: 75–200 mg) and 190 received placebo. Efficacy measures were assessed through 72 hours after surgery.

ABSTRACT.RESULTS: Overall, 45% of patients were male and 19% were ≥65 years of age. In the analysis of cumulative pain intensity scores through 72 hours, liposome bupivacaine was associated with lower pain scores than the comparator in 16 of 19 treatment arms assessed, achieving statistically significant differences compared with bupivacaine HCl (P < 0.05) in five of 17 treatment arms. These results were supported by results of other efficacy measures, including time to first use of opioid rescue medication, proportion of patients avoiding opioid rescue medication, total postsurgical consumption of opioid rescue medication, and patient/care provider satisfaction with postoperative analgesia. Local infiltration of liposome bupivacaine resulted in significant systemic plasma levels of bupivacaine, which could persist for 96 hours; systemic plasma levels of bupivacaine following administration of liposome bupivacaine were not correlated with local efficacy. Liposome bupivacaine and bupivacaine HCl were generally well tolerated.

ABSTRACT.CONCLUSION: Based on this integrated analysis of multiple efficacy measures, liposome bupivacaine appears to be a potentially useful therapeutic option for prolonged reduction of postsurgical pain in soft tissue and orthopedic surgeries.

Findings:
[["liposome bupivacaine", "bupivacaine HCl", "cumulative pain", "significantly decreased", "In the analysis of cumulative pain intensity scores through 72 hours, liposome bupivacaine was associated with lower pain scores than the comparator in 16 of 19 treatment arms assessed, achieving statistically significant differences compared with bupivacaine HCl (P \u003c 0.05) in five of 17 treatment arms"], ["liposome bupivacaine 266 mg ", "placebo", "\"satisfied\ufffd or \"extremely satisfied\ufffd with their postoperative analgesia at 24 hours after surgery", "significantly increased", "At 24 hours after surgery in this study, 95% of patients in the liposome bupivacaine 266 mg group were \"satisfied\" or \"extremely satisfied\" with their postoperative analgesia compared with 72% in the placebo group (P = 0.0007). "], ["liposome bupivacaine 266 mg ", "placebo", "\"satisfied\ufffd or \"extremely satisfied\ufffd with their postoperative analgesia at 72 hours after surgery", "significantly increased", "At 24 hours after surgery in this study, 95% of patients in the liposome bupivacaine 266 mg group were \"satisfied\" or \"extremely satisfied\" with their postoperative analgesia compared with 72% in the placebo group (P = 0.0007). At 72 hours after surgery, percentages were 95% and 73%, respectively (P = 0.0007)."]]