You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["HealthCareActivity", "InjuryOrPoisoning", "BodySubstance", "IntellectualProduct", "AnatomicalStructure", "SpatialConcept", "Chemical", "Bacterium", "MedicalDevice", "Organization", "BiomedicalOccupationOrDiscipline", "Finding", "BiologicFunction", "Virus", "ResearchActivity", "ClinicalAttribute", "PopulationGroup", "Eukaryote", "BodySystem", "Food", "ProfessionalOrOccupationalGroup"].

Please return the output as a JSON object of the format: {"Virus": ["HIV", ...], "Bacterium": ["MRSA", ...], "AnatomicalStructure": ["Lung", ...], "BodySystem": ["CNS", ...], "BodySubstance": ["Serum", ...], "Finding": ["Headache", ...], "InjuryOrPoisoning": ["Fracture", ...], "BiologicFunction": ["Death", ...], "HealthCareActivity": ["Biopsy", ...], "ResearchActivity": ["Clinical trial", ...], "MedicalDevice": ["Lenses", ...], "SpatialConcept": ["Camps", ...], "BiomedicalOccupationOrDiscipline": ["Forensic medicine", ...], "Organization": ["WHO", ...], "ProfessionalOrOccupationalGroup": ["Provider", ...], "PopulationGroup": ["Swimmers", ...], "Chemical": ["Gold", ...], "Food": ["Rice", ...], "IntellectualProduct": ["RPAM", ...], "ClinicalAttribute": ["Biomarker", ...], "Eukaryote": ["Dogs", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Physicochemical characterization of chitosan - hyaluronan -coated solid lipid nanoparticles for the targeted delivery of paclitaxel: a proof-of-concept study in breast cancer cells To investigate the potential of modified solid lipid nanoparticles (SLN) for the delivery of paclitaxel (PAX). SLN loaded with PAX were prepared via modified high-pressure hot homogenization. Formulation parameters were optimized to obtain a high-quality delivery system. SLN cores were coated, layer-by-layer, with a chitosan and hyaluronan (HA) shell. Selectivity toward HA receptors was tested in a breast cancer cell line, MCF-7. Stable and reproducible nano-sized and negatively charged nanoparticles resulted. Findings reveal that chitosan - HA -coated SLN facilitated the targeting, cellular uptake and the time-/dose-controlled delivery and release of PAX, enhancing intrinsic chemotherapeutic activities. SLN are suitable carrier candidates for nano-oncology given their localized, and potent cytotoxic potential overcoming multidrug-resistant cancer cells.
{"AnatomicalStructure": ["breast cancer cell line", "breast cancer cells", "MCF-7"], "Bacterium": [], "BiologicFunction": ["cellular uptake", "multidrug-resistant cancer cells"], "BiomedicalOccupationOrDiscipline": ["nano-oncology"], "BodySubstance": [], "BodySystem": [], "Chemical": ["HA", "paclitaxel", "cytotoxic potential", "hyaluronan", "SLN loaded with PAX", "receptors", "PAX", "chitosan"], "ClinicalAttribute": [], "Eukaryote": [], "Finding": ["overcoming"], "Food": [], "HealthCareActivity": ["high-pressure hot homogenization", "delivery"], "InjuryOrPoisoning": [], "IntellectualProduct": [], "MedicalDevice": ["lipid nanoparticles", "SLN", "solid lipid nanoparticles", "high-quality delivery system", "carrier candidates"], "Organization": [], "PopulationGroup": [], "ProfessionalOrOccupationalGroup": [], "ResearchActivity": ["proof-of-concept study", "Formulation parameters"], "SpatialConcept": [], "Virus": []}