Given an abstract from a research paper, your task is to identify and label relationships between chemical compounds and genes mentioned in the abstract.

The relationship type must be one of ['DOWNREGULATOR', 'SUBSTRATE', 'INDIRECT-REGULATOR', 'PART-OF', 'MODULATOR-ACTIVATOR', 'REGULATOR', 'INHIBITOR', 'COFACTOR', 'UPREGULATOR', 'ACTIVATOR', 'ANTAGONIST', 'NOT', 'INDIRECT-DOWNREGULATOR', 'SUBSTRATE_PRODUCT-OF', 'INDIRECT-UPREGULATOR', 'AGONIST', 'PRODUCT-OF', 'MODULATOR', 'DIRECT-REGULATOR', 'UNDEFINED', 'AGONIST-INHIBITOR', 'AGONIST-ACTIVATOR', 'MODULATOR-INHIBITOR'].

Please format your output as a JSON array. Each entry in the array should express a single relation, formatted as ["<Entity_A>", "<RELATION_A_B>", "<Entity_B>"]. If no relations can be found, please output an empty JSON array [].

Abstract:

Anti-inflammatory effects of trans-1,3-diphenyl-2,3-epoxypropane-1-one mediated by suppression of inflammatory mediators in LPS-stimulated RAW 264.7 macrophages. To assess the potential therapeutic properties of trans-1,3-diphenyl-2,3-epoxypropane-1-one (DPEP), its anti-inflammatory effects were investigated in lipopolysaccharide (LPS) -stimulated mouse macrophage (RAW 264.7) cells. DPEP induced dose-dependent reduction of the protein levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) and concomitant reduction in the production of NO and prostaglandin E (2) (PGE (2)). Additionally, DPEP suppressed the production of inflammatory cytokines, including tumor necrosis factor-α (TNF-α), interleukin (IL) -1β, and IL-6. We investigated the mechanism by which DPEP inhibits NO and PGE (2) by examining the level of nuclear factor-κB (NF-κB) activation within the mitogen-activated protein kinase (MAPK) pathway, which is an inflammation-induced signaling pathway in RAW 264.7 cells. DPEP inhibited LPS-induced phosphorylation of ERK, JNK, and p38. Furthermore, DPEP inhibited the LPS-induced phosphorylation of inhibitor κB (IκB) -α and NF-κB p50. Taken together, the results of this study demonstrate that DPEP inhibits LPS-stimulated inflammation by blocking the NF-κB and MAPK pathways in macrophages.
[["DPEP", "INHIBITOR", "inhibitor \u03baB (I\u03baB) -\u03b1"], ["DPEP", "INHIBITOR", "p50"], ["DPEP", "INDIRECT-DOWNREGULATOR", "inducible nitric oxide synthase"], ["DPEP", "INDIRECT-DOWNREGULATOR", "iNOS"], ["DPEP", "INDIRECT-DOWNREGULATOR", "IL-6"], ["DPEP", "INHIBITOR", "p38"], ["DPEP", "INDIRECT-DOWNREGULATOR", "COX-2"], ["DPEP", "INHIBITOR", "NF-\u03baB"], ["DPEP", "INDIRECT-DOWNREGULATOR", "cyclooxygenase-2"], ["DPEP", "INDIRECT-DOWNREGULATOR", "cytokines"], ["DPEP", "INHIBITOR", "MAPK"], ["DPEP", "INHIBITOR", "ERK"], ["DPEP", "INDIRECT-DOWNREGULATOR", "interleukin (IL) -1\u03b2"], ["DPEP", "INDIRECT-DOWNREGULATOR", "TNF-\u03b1"], ["DPEP", "INDIRECT-DOWNREGULATOR", "tumor necrosis factor-\u03b1"], ["DPEP", "INHIBITOR", "JNK"]]