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enuresis , often called bedwetting or sleep wetting , is a common problem in children after the age of five and may lead to symptoms such as infection , incontinence and frequent urination ( 1 ) .
primary nocturnal enuresis is a common problem among school - aged children ( 2 ) .
this problem refers to the state in which a child after the age of five has no control of his / her urine for six continuous months and it can not be attributed to any organic factors or drug use ( 3 , 4 ) . in the international classification of diseases and related health problems-10 revision ( icd-10 ) involuntary urination at night more than twice a month in children under seven and once a month in children above seven and in dsm - iv - tr more than twice per week for three months is accepted as primary nocturnal enuresis ( 5 , 6 ) .
so far a clear explanation for enuresis has not been proposed yet several factors such as reduced bladder capacity , delays in development , nocturnal polyuria , sleep disorders , snoring at night , psychological issues etc .
most children with primary nocturnal enuresis have significant signs of stress and mental problems and most of the symptoms are anxiety disorders ( 10 - 12 ) .
( 13 ) ( 2014 ) showed that 60% of patients with enuresis disorder had at least one mental factor .
anxiety disorders are very common and are involved in about 5% - 10% of children and adolescents ( 14 - 17 ) .
given that bed - wetting is a common problem in school - age children and studies regarding the relationship between generalized anxiety disorder and primary nocturnal enuresis have not been performed in iran thus this study aimed to investigate the relationship between generalized anxiety disorder and primary nocturnal enuresis .
this study was a case - control study that was performed on 180 children aged between 7 and 17 years old with primary nocturnal enuresis as the patient group and 180 healthy children as the control group .
the participants were selected from patients referred to amir kabir hospital of arak , iran during year 2014 . in this study
, we tried to match demographic characteristics such as age , gender , number on children in the family , presence of parents in the family and etc .
anxiety was measured by a questionnaire to detect anxiety disorders in children ( scared ) and the score was recorded with the approval of a psychiatrist based on dsm iv 
inclusion criteria were the diagnosis of primary nocturnal enuresis based on the book by nelson and approval of a specialist in pediatric urinary tract .
exclusion criteria were having underlying psychological problems , mental retardation , using tranquilizers or anti - epileptic drugs , all underlying structural problems in kidney and urinary tract and parasitic diseases .
also , anybody who was not willing to continue to participate in the study was excluded from the study .
armonk , ny : ibm corp . ) , and interpreted by chi - square and odds ratio method .
informed consent was obtained from parents of all children and children over 12 years were also informed about the purpose of the study .
use of the information was anonymous and patients were coded by numbers in the questionnaire . in addition , parents were able to end their participations at any time of the study .
the helsinki ethics statements and ethical statement of research ethics committee of arak university of medical sciences were considered at all stages of the research .
inclusion criteria were the diagnosis of primary nocturnal enuresis based on the book by nelson and approval of a specialist in pediatric urinary tract .
exclusion criteria were having underlying psychological problems , mental retardation , using tranquilizers or anti - epileptic drugs , all underlying structural problems in kidney and urinary tract and parasitic diseases .
also , anybody who was not willing to continue to participate in the study was excluded from the study .
armonk , ny : ibm corp . ) , and interpreted by chi - square and odds ratio method .
informed consent was obtained from parents of all children and children over 12 years were also informed about the purpose of the study .
use of the information was anonymous and patients were coded by numbers in the questionnaire . in addition , parents were able to end their participations at any time of the study . the helsinki ethics statements and ethical statement of research ethics committee of arak university of medical sciences were considered at all stages of the research .
after receiving demographic information and trying to synchronize the data , we asked the parents to answer the questions . based on the obtained scores these results
were obtained : in the case of gad , 46 of participates scored 9 and higher so the prevalence of the mentioned disease in the patient group was 12.8% .
( % ) or mean  sd . in the case of history of anxiety ,
12.2% of fathers and 28.9% of mothers stated a history of anxiety in their own life .
however , these ratios were lower in the control group . referring to these data , the history of anxiety in mothers was significant ( p = 0.0001 ) but in fathers the differences were not significant ( p = 0.19 ) ( table 2 ) .
in this study the history of anxiety in mothers of the patient group was significantly higher than that of the control group and also regarding the gained scores in gad , a clear relationship between gad and primary nocturnal enuresis was recorded .
since no similar studies were found , accurate comparison with other studies was not possible so to compare the results ; studies with similar titles are discussed below .
logan et al . in 2014 showed that among 216 patients with urinary dysfunction , about 60% had at least one mental problem ( 13 ) . in another study on psychological profile of women with urinary dysfunction performed by fan
, it was shown that people with urinary dysfunction were more likely to have depression and anxiety than the control group ( 14 ) . in 2012 , wolfe - christensen et al .
( 19 ) performed a survey on  psychosocial problems in children referred to urology clinics  and reported that in total 15.2% of children had serious psychosocial and social problems .
however , children with functional urinary tract disorders and primary nocturnal enuresis had a greater risk of mental problems and with increasing mental - social problems the severity of urology disease also increased .
it was shown that psychosocial and stress during the sensitive time of learning for voluntary urination may cause primary nocturnal enuresis . in another study by eapen
( 20 ) nocturnal enuresis was found to be very common in school - aged children and it was recommended for all children to be carefully evaluated for psychological damage . in conclusion the results obtained from this study show that there was a clear significant difference between the two control and patient groups for all subgroups of anxiety disorders such as gad and their relationship with primary nocturnal enuresis .
the strength point of this study could be that this complication was studied for the first time in iran and can guide further studies in the future .
lack of cooperation of some parents for inclusion was one of the major limitations in this and similar studies .
we recommend further researches to be performed in other geographical areas with larger sample sizes to accept or reject the results of this study .
backgroundnocturnal enuresis , often called bedwetting or sleep wetting , is a common problem in children after the age of five and may lead to symptoms such as infection , incontinence and frequent urination . 
 this problem refers to a state in which children after the age of five have no control of their urine for six continuous months and it can not be attributed to any organic factors or drug use.objectivesin this study we aimed to study generalized anxiety disorder as one of the possible causes of primary nocturnal enuresis.materials and methodsin this case - control study 180 children with primary nocturnal enuresis and same number of healthy children with a mean age of 7 - 17 years old with the same demographic characteristics were selected . 
 the study took place at amir kabir hospital of arak , iran during year 2014 . 
 after collecting the information , diagnosis was verified based on the diagnostic and statistical manual of mental disorders ( dsm ) iv - tr criteria . 
 results were analyzed using the spss software ( ibm corp . released 2011 . 
 ibm spss statistics for windows , version 20.0 . 
 armonk , ny : ibm corp.).resultsfrequency of generalized anxiety disorder , panic disorder , school phobia , social anxiety , separation anxiety , history of anxiety in mother , history of primary nocturnal enuresis in parent s family and body mass index had a significant difference between the two groups ( p = 0.005).conclusionswith the results obtained from this study we could say that there was a clear significant difference between the two control and patient groups for all subgroups of anxiety disorders such as generalized anxiety disorder and their relationship with primary nocturnal enuresis . 
 given the higher prevalence of generalized anxiety disorder , panic disorder , school phobia , social anxiety , separation anxiety and comparison with healthy children , it is recommended for all children with primary nocturnal enuresis to be investigated and treated for generalized anxiety disorder .