You will be presented with the full text of a biomedical research paper. Please write an abstract for this paper. Your response should include the abstract and no additional text.

Paper text:
 chemical attack is becoming a real threat worldwide . in 2013 , two deadly chemical exposures occurred in different countries .
there were deaths of 23 children in bihar , india from accidental poisoning with the farmgrade organophosphate ( op ) pesticide monocrotophos , with many more hospitalized . in syria , about 1,400 civilians died from the weaponsgrade nerve gas sarin attacks . over a decade ago tokyo civilians were exposed to the labgrade sarin gas on the subway . 
while exposure to op pesticides and nerve agents can result in severe detriment on the victimized population , including death in many cases , there is limited information on human exposure , especially the neurotoxicity sequelae after acute poisoning and the longterm constellation of signs and symptoms after initial exposure .
this study utilized a social media tool to compare the toxidrome of three lethal chemical exposures worldwide and attempted to differentiate a pesticide exposure that has more muscarinic effects from nerve agent that predominates with nicotinic toxicity .
 analysis of mass exposures is now feasible by using a novel tool  social media .
videos are available on the internet that allows each incident to be observed , categorized , and archived in digital format .
analysis of the rare videos of three distinct op poisoning incidents uncovered a set of clinical fingerprints that indicate a specific group of cholinergic toxicants as lethal threat agents for humans .
 comparative toxidrome data might help optimize early detection toward creating better antidote therapies for chemical poisonings , improve preparedness for chemical attacks , and display the need for longterm medical followup for victims of nerve agent attacks .
such toxidrome analysis may help developing a triage system for longterm monitoring of victims in case of mass attacks .
 chemical attack is becoming a real threat worldwide . in 2013 , two deadly chemical exposures occurred in different countries .
there were deaths of 23 children in bihar , india from accidental poisoning with the farmgrade organophosphate ( op ) pesticide monocrotophos , with many more hospitalized . in syria , about 1,400 civilians died from the weaponsgrade nerve gas sarin attacks . over a decade ago tokyo civilians were exposed to the labgrade sarin gas on the subway .
 while exposure to op pesticides and nerve agents can result in severe detriment on the victimized population , including death in many cases , there is limited information on human exposure , especially the neurotoxicity sequelae after acute poisoning and the longterm constellation of signs and symptoms after initial exposure .
this study utilized a social media tool to compare the toxidrome of three lethal chemical exposures worldwide and attempted to differentiate a pesticide exposure that has more muscarinic effects from nerve agent that predominates with nicotinic toxicity .
 analysis of mass exposures is now feasible by using a novel tool  social media .
videos are available on the internet that allows each incident to be observed , categorized , and archived in digital format .
analysis of the rare videos of three distinct op poisoning incidents uncovered a set of clinical fingerprints that indicate a specific group of cholinergic toxicants as lethal threat agents for humans .
 comparative toxidrome data might help optimize early detection toward creating better antidote therapies for chemical poisonings , improve preparedness for chemical attacks , and display the need for longterm medical followup for victims of nerve agent attacks .
such toxidrome analysis may help developing a triage system for longterm monitoring of victims in case of mass attacks .
we performed a search on the videosharing website youtube ( google , mountain view , ca ; http://www.youtube.com ) and other online news portals for videos available as of july 2014 .
in addition to video searches , comments and news items were searched for additional information regarding the victim and incident . due to the public nature of the websites ,
youtube videos were collected for each of the three events ( india , syria , tokyo ) , using key word searches on the internet .
key words included : pesticide , nerve agent , organophosphate , sarin , chemical exposure , syria , tokyo , india , chemical exposure .
the videos were downloaded and watched as described previously.1 each video was assigned an identifier and information on each victim ( estimated age , gender , and symptoms ) was recorded in a spreadsheet .
there were a total of 38 videos collected : 22 from syria , 8 from tokyo , and 8 from india .
the indian case was covered widely in press and social media . on 16 july 2013 ,
at least 23 students died and dozens more fell ill at a primary school in the village of dharmashati gandaman in the saran district of the indian state of bihar after eating a midday meal contaminated with pesticide.1 , 17 , 18 official investigations stated that the cooking oil had been placed in a container that was previously used to store insecticides .
a forensic report confirmed the cooking oil contained " very toxic " levels of monocrotophos , an agricultural op pesticide .
the amount consumed was not estimated , but victims had approximately the same serving of lunch from the same contaminated pot . within 30 min after eating the meal , the children complained of stomach pain and soon after were taken ill with vomiting , diarrhea , and body jerks .
the syrian case had the most youtube hits , perhaps due to the demographics of the event .
it happened on august 21 , 2013 ; cell phones were available and popular and videos were relatively easy to record .
there were probably fewer hits in india because the incident was food poisoning in a school that not only caused delayed effects , but was initially presumed  normal 
in addition , while cell phones were readily available in 2013 , camera phones would not be a norm for children or school administration in bihar , india .
the only video access would have been if a person had a video recorder , or a news crew was nearby .
image searches on google were also utilized to find still pictures of the attacks to identify symptoms .
the pictures were also given a unique identifier and recorded in a spreadsheet with corresponding victim information such as estimated age , gender , and symptoms .
it was visually checked by the investigators that many of the pictures were obtained from the videos previously collected , and therefore the duplicative information was not included in the overall analysis .
news reports of each incidence , along with published literature ( primary , secondary , and tertiary ) were also collected and documented to determine additional details about each individual incident of nerve agent exposure .
after the data were compiled into a spreadsheet , each symptom was tallied by incident .
severe symptoms included : respiratory depression , seizure activity , unconsciousness , convulsions , and hypersecretion .
moderate symptoms included : fasciculations , miosis , vomiting , and any eye pain or blurred vision reported verbally in the videos .
mild symptoms included : weakness or limpness of the body , excessive sweating , coughing , headache , and screaming , crying , or any visibly upset or distressed state .
victims who had no noticeable signs of life or considered dead were excluded from the symptomatic analysis . for each op chemical exposure , a pie graph was created to determine the respective percentage of severe , moderate , and mild symptoms .
these graphs were then used , along with the published literature , to draw conclusions from the data collected .

 figure 
 2 shows representative images and descriptions of symptoms observed after pesticide and nerve agent poisoning of the victims .
table 
 1 shows the comparative analysis of the data documented from each of the three different incidents .
the age range seen in the tokyo videos was from mostly young to middleaged adults , probably due to the fact that the time of the event occurred during the commute to work .
no children were observed in the tokyo case . the indian case had the least variability in age , ranging from 5 to 12 years , which was expected as this occurred at a primary school .
victims were approximately the same age and probably had similar maximum exposures of pesticide mixed with lunch food of similar servings .
in contrast to tokyo and syria , the indian victims were accidently exposed to monocrotophos , a pesticides used in agriculture , as compared with intentional terrorist attacks of nerve agents in the other two cases .
comparative signs and symptoms of organophosphate and nerve agent poisonings in humans in three separate incidents worldwide . respiratory depression later on by ambulance low plasma cholinesterase decreased psychomotor performance increased sister chromatid exchanges ( genetic effects ) tonic clonic seizures seizure / muscle convulsions cognitive dysfunction from the analysis of the videos and collected data ( figure 
 2 ) , syria had the largest percentage of severe symptoms , which corresponds with the large number of deaths ( 1,400 ) .
syria was followed by tokyo , with 46% severe symptoms , but in tokyo there was also a notable percentage of mild symptoms ( 32% ) .
india had over 50% mild symptoms , but a notable number of either moderate or severe cases .
a chart was created to depict a sidebyside comparison of each incident ( figure 
 3 ) .
tokyo had the most resources for advanced treatment , which may account for the limited number of lives lost .
tokyo is also a large metropolitan city , with easy and fast access to healthcare and medications , whereas the events in syria and india were in more rural areas that required travel to seek medical attention .
percent of severity of symptoms observed in the three distinct human organophosphate poisoning incidents worldwide .
the outcomes from this study attest that the toxidrome can be predictable based on the agent ( pesticide vs. nerve agent ) and exposure ( ingestion vs. inhalation ) .
the pilot toxidrome observed from these videos show the constellation of signs and symptoms that are distinctly different in each of the three incidents .
ops are different from nerve agents and the route was ingestion , while the syrian nerve gas attacks were , as noted , military with higher concentrations / dose delivered vs. tokyo with many socalled exposed getting minimal to no exposure . these factors , as well as healthcare resources , impacted morbidity and mortality in the three cases .
the novel research application of social media brings a useful tool to bear on these exposures .
the findings from observing the videos of the syrian and tokyo attacks can be used as a model for the indian pesticide poisoning .
lessons learned from the two larger cases with more severe symptomology can be applied to smaller pesticide cases such as what occurred in india .
this is important because , although the indian cases resulted in the majority of victims with mild symptoms , they are more at risk for severe delayed neurological effects.8 , 9 , 10 because many survivors in india are young , longterm followup in this group is feasible .
tokyo and syria can be used as a model for the toxidrome crisis of the indian incident because all the compounds fall into the chemical classification of ops , and most ops are irreversible ache inhibitors ; thus , acting much like chemical weapons such as soman , vx , and sarin.1 in the indian videos , the severe symptoms such as convulsions , seizures , and respiratory depression were less frequent .
this is probably due the fact that a longer time elapsed between diagnosis and treatment , compared with the events recorded in tokyo and syria .
it is also likely that such symptoms did occur in the indian children who died and possibly others who survived , but whose symptoms were not videotaped because it happened in a remote village . like a previous study,4 this study has some caveats , such as limited authenticity or validation of the videos , lack of medical orientation of the videos cited , lack of background control data , and incomplete medical information of the victims .
nevertheless , the abundance of information helps to validate the information in a way similar to  crowd wisdom ,  in which quantity and diversity compensate for quality.4 nevertheless , this pilot study may set the stage for a largescale , multinational social media study on nerve agent toxidrome , treatment efficacy , and followup on longterm effects of survivors . in all three incidents ,
atropine is a highly recommended treatment , but this requires intravenous access and must be administered by a medical professional in a healthcare setting .
this is not always feasible during mass chemical attacks.11 the quick access to antidote autoinjectors would allow faster administration of the drug and decrease mortality.12 currently , atropine and 2pam autoinjectors are only available to military personnel in the united states . allowing such access to populations at risk of a chemical attack should increase survival rates and allow for more time for victims to seek medical attention .
adequate stocks of better antidotes that can provide neurological protection would be beneficial in populations of people who are at risk for op exposure . the need for quick diagnosis of a specific toxidrome and access to these medications is also an area in need of improvement .
when severe symptoms such as seizure activity ensue , it is a concern that longterm damage or development of neurological dysfunction could result in victims after the acute symptoms subside . due to neuronal damage by cholinergic crisis
, there is a greater likelihood for chronic neurological and neuropsychiatric complications in the future .
perhaps an even more alarming fact is that those exposed people who may not have shown acute symptoms of op poisoning , could be more sensitive to longterm neurotoxic effects.1 this is consistent with the notion that longterm toxicity from op exposure may be underreported and more prevalent in cases of mild exposure , such as the indian case .
such symptoms could be attributed to a different origin , when in fact it is a result of op exposure .
these concerns illustrate the importance of chronic followup data on the harm of op poisoning given the limited effectiveness of current antidote treatments .
animal models are important in the understanding of some of the neurotoxic effects that may be experienced short and longterm in humans.13 , 14 the longterm effects of op exposure first seen after the tokyo attack arose from nonache inhibition , because ops have secondary targets.15 glutamate is an excitatory neurotransmitter in the brain responsible for critical functions such as cognition , memory , and learning.16 when glutamate is in excess , it can cause excitotoxic neurotoxicity and massive neuronal synaptic damage leading to longterm neuropsychiatric dysfunction.16 excess glutamate is a caused by superfluous activation of cholinergic receptors in the brain .
seizures are initially triggered by excess cholinergic hyperactivation , but are continued by persistent glutamatergic transmission within the brain synapses .
effective control of seizures is critical for survival as well as preventing neuronal damage or longterm neurological dysfunction . in conclusion , with the vast availability of social media , chemical attacks can be well documented and accessed worldwide .
the videos can be used as a research tool to draw conclusions about the victimized population as a whole . by analyzing three separate op attacks
, we were able to compare the toxidrome from each and use a largescale deconstruction as a model for comparison and drawing conclusions . by possibly utilizing the indian case as a future population for longterm followup and development of chronic toxicity
, we can better categorize the delayed neurotoxicity of op exposure in survivors , as well as increase preparedness should another attack occur .
these incidents underscore the need for better antidotes and followup of victims for neurological or longterm symptoms .
here we utilized social media to compare the toxidrome of three lethal chemical exposures worldwide . 
 youtube videos were the main source from which the data were collected , but published reports and news were also utilized to fill in some gaps . 
 all videos were organized in a database detailing symptoms and severity of each victim , along with demographics such as approximate age and gender . 
 each symptom was rated as mild , moderate , or severe and corresponding pie graphs for each incident were compared . 
 the videos displayed symptoms ranging from mild to severe cholinergic toxicity and lifethreatening convulsions . 
 social media may represent an important resource in developing a viable approach to the early detection and identification of chemical exposure , reinforce our preparedness for better antidotes , longterm follow up , and training about deadly chemical nerve agent attacks .