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Paper text:
aav2/8 was produced by transient transfection and purification from culture supernatant by peg precipitation and cesium chloride ultracentrifugation .
virus was quantified by qpcr against cmv sequences and functionally validated in vitro to confirm gene expression prior to use in vivo .
antibody concentration in the serum was determined using an elisa specific for either total human igg or human igg against hiv - gp120 .
humanized mice expressing antibodies were produced by adoptive transfer of expanded hupbmcs into mice previously transduced with aav vectors .
hiv challenge was carried out via ip or iv injection and blood was sampled weekly to determine the ratio of cd4 to cd8 cells by flow cytometry .
despite tremendous efforts , development of an effective vaccine against hiv has proved an elusive goal . recently 
 , however , numerous antibodies have been identified that are capable of neutralizing the vast majority of circulating hiv strains15 . 
 these antibodies all exhibit an unusually high level of somatic mutation6 , presumably due to extensive affinity maturation over the course of continuous exposure to an evolving antigen7 . 
 while substantial effort has focused on the design of immunogens capable of eliciting antibodies de novo that would target similar epitopes810 , it remains uncertain whether a conventional vaccine will be able to elicit analogs of the existing broadly neutralizing antibodies . as an alternative to immunization , vector - mediated gene transfer could be used to engineer secretion of the existing broadly neutralizing antibodies into the circulation . 
 here we describe a practical implementation of this approach , vectored immunoprophylaxis ( vip ) , which in mice induces lifelong expression of these monoclonal antibodies at high concentrations from a single intramuscular injection . 
 this is achieved using a specialized adeno - associated virus ( aav ) vector optimized for the production of full - length antibody from muscle tissue . 
 we show that humanized mice receiving vip appear to be fully protected from hiv infection even when challenged intravenously with very high doses of replication - competent virus . 
 our results suggest that successful translation of this approach to humans may produce effective prophylaxis against hiv .