You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["RNA", "CellLine", "Protein", "DNA", "CellType"].

Please return the output as a JSON object of the format: {"DNA" : ["TAL1", ...], "RNA": ["mRNAs", ...], "CellLine": ["T cells", ...], "CellType": ["monocytes", ...], "Protein": ["IL-2", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Glucocorticoid receptors in lymphocytes in anorexia nervosa. OBJECTIVE: The aim was to explore the down-regulation of the glucocorticoid receptors during hypercortisolaemia in anorexia nervosa. DESIGN: Urine and plasma samples were obtained for cortisol determination and blood lymphocytes were isolated for receptor binding studies. PATIENTS: Sixteen anorexic patients, aged 16-27 years, with a mean + /-SEM body mass index of 14. 2 + /-2. 0 (ranging from 11. 1 to 17. 4), and 15 normal women were studied. Six patients were reinvestigated after a significant weight gain. MEASUREMENTS: The binding capacity and affinity of the glucocorticoid receptors were measured with dexamethasone as ligand on lymphocytes. RESULTS: In patients, both total and free plasma cortisol concentrations were higher than in the normal women, as was their urinary free cortisol; the number of glucocorticoid receptors per cell (Ro) and the binding affinity (Kd) for dexamethasone were, however, not significantly different (Ro: 7687 + /-1750 vs 7347 + /-1285 sites / cell; Kd: 7. 7 + /-2. 4 vs 7. 4 + /-1. 7 nM at 24 degrees C). After weight gain (14 + /-2 to 16 + /-2 kg / m2), receptor numbers were 8421 + /-2126 (pre) and 9011 + /-500 (post) sites / cell, which are not significantly different (P greater than 0. 2); the Kd was unchanged (9. 3 + /-2. 6 vs 9. 2 + /-2. 4 nM). CONCLUSIONS Hypercortisolaemia does not down-regulate the lymphocyte glucocorticoid receptors in anorexia nervosa and a post-receptor defect might be involved in peripheral tissue resistance to the effects of glucocorticoid hormones in undernutrition.
{"CellLine": [], "CellType": ["blood lymphocytes", "lymphocytes"], "DNA": [], "Protein": ["the glucocorticoid receptors", "Glucocorticoid receptors", "glucocorticoid receptors"], "RNA": []}