Given an abstract from a research paper, your task is to identify and label relationships between chemical compounds and genes mentioned in the abstract.

The relationship type must be one of ['DOWNREGULATOR', 'SUBSTRATE', 'INDIRECT-REGULATOR', 'PART-OF', 'MODULATOR-ACTIVATOR', 'REGULATOR', 'INHIBITOR', 'COFACTOR', 'UPREGULATOR', 'ACTIVATOR', 'ANTAGONIST', 'NOT', 'INDIRECT-DOWNREGULATOR', 'SUBSTRATE_PRODUCT-OF', 'INDIRECT-UPREGULATOR', 'AGONIST', 'PRODUCT-OF', 'MODULATOR', 'DIRECT-REGULATOR', 'UNDEFINED', 'AGONIST-INHIBITOR', 'AGONIST-ACTIVATOR', 'MODULATOR-INHIBITOR'].

Please format your output as a JSON array. Each entry in the array should express a single relation, formatted as ["<Entity_A>", "<RELATION_A_B>", "<Entity_B>"]. If no relations can be found, please output an empty JSON array [].

Abstract:

Phorbol esters and norepinephrine destabilize alpha 1B-adrenergic receptor mRNA in vascular smooth muscle cells. The mechanism by which norepinephrine (NE) down-regulates alpha 1B-adrenergic receptor (alpha-AR) mRNA was studied in rabbit aortic smooth muscle cells. NE, phorbol esters, and bradykinin each decreased alpha-AR mRNA levels by 70-80%. The protein kinase C inhibitor (+) -1- (5-isoquinolinesulfonyl) -2-methylpiperazine dihydrochloride (H-7) abolished the effects of phorbol esters and NE and decreased basal mRNA levels by 52 + /- 3%. Neither ryanodine nor EGTA inhibited down-regulation of alpha-AR mRNA by NE. Actinomycin D caused alpha-AR mRNA level to decrease with a half-life of 3.2 + /- 0.4 h and blocked the effect of H-7 to decrease basal alpha-AR mRNA level. Both NE and phorbol esters increased the rate of alpha-AR mRNA degradation. In NE-desensitized cells, phorbol esters and bradykinin each caused the expected down-regulation of alpha-AR mRNA. The protein phosphatase inhibitor okadaic acid prolonged the normally transient effect of NE for at least 24 h. We conclude that protein kinase C exerts two opposing effects on alpha-AR mRNA levels, 1) a decrease in the stability of the mRNA that requires the sustained phosphorylation of a protein kinase C substrate and 2) a permissive effect on alpha-AR gene transcription.
[["NE", "INDIRECT-DOWNREGULATOR", "alpha 1B-adrenergic receptor"], ["norepinephrine", "INDIRECT-DOWNREGULATOR", "alpha-AR"], ["NE", "INDIRECT-DOWNREGULATOR", "alpha-AR"], ["phorbol esters", "INDIRECT-DOWNREGULATOR", "alpha-AR"], ["EGTA", "INDIRECT-UPREGULATOR", "alpha-AR"], ["H-7", "INDIRECT-REGULATOR", "alpha-AR"], ["H-7", "INHIBITOR", "protein kinase C"], ["Actinomycin D", "INDIRECT-DOWNREGULATOR", "alpha-AR"], ["okadaic acid", "INHIBITOR", "protein phosphatase"], ["ryanodine", "INDIRECT-UPREGULATOR", "alpha-AR"], ["+) -1- (5-isoquinolinesulfonyl) -2-methylpiperazine dihydrochloride", "INHIBITOR", "protein kinase C"], ["norepinephrine", "INDIRECT-DOWNREGULATOR", "alpha 1B-adrenergic receptor"]]