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recently , there has been a resurgence of tuberculosis ( tb ) in developing and developed countries although mostly due to the increasing prevalence of hiv24 ) .
tuberculosis infection involving the spine may be classified as pott 's spine and pott 's paraplegia , nonosseous spinal tuberculoma ( extradural , intradural extramedullary , intramedullary ) , tuberculous arachnoiditis ( myeloradiculopathy ) , and spinal meningitis6 ) . among these ,
nonosseous spinal tuberculoma is extremely rare13 ) . from dastur 's review4 ) , 64% of tuberculomas are extradural , 8% are intramedullary , and 1% are intradural extramedullary ; the rest ( 27% ) of the lesions involve the arachnoid without dural involvement .
intradural extramedullary tuberculoma of the spinal cord(ietsc ) is a rare modality of tb and it is usually associated with the concurrent tuberculous meningitis . since compton and dorsch1 ) reported an intradural extramedullary tuberculoma case in 1984 , there have been 24 cases reported in the english literature13,15,20,22 ) . even in countries where tb is endemic ,
although the paradoxical response to antituberculous therapy is suspected of one of the liable pathogenesis , the cause is unclear11 ) .
we would like to report a case of intradural extramedullary tuberculoma considered as a long - term sequela .
a 45-year - old man presented with aggravated gait disturbance one month ago affecting his lower extremity .
the paresthesia and loss of proprioception were so evident in the lower extremity that he could not stand alone and walk around .
however , he did not complain of fever , sweating , and neck stiffness . in the past medical history ,
the patient suffered from pulmonary tuberculosis five years ago and had been treated with four - drug therapy for nine months .
although he had the mild paresthesia in the lower extremity several months after anti - tb medications at that time , the evaluation of spinal involvement was not performed .
magnetic resonance ( mr ) imaging revealed the t3 - 7 intradural extramedullary plaque - shaped mass with the dark signal intensity on t2-weighted images , isosignal on t1-weighted images , and heterogeneous enhancement on gadolinium - enhanced images .
the lesion had the broader base on the dorsal - inner dural layer in the thoracic spine and demonstrated the guttering appearance in the direction to the dorsal surface of spinal cord .
there was a stalk - like connection between the intradural mass and the most compressed spinal cord ( fig .
1 ) . computed tomograms ( ct ) showed the stippled dot of calcification in the stalk - like portion of mass on the t5 - 6 disc level ( fig .
the initial differential diagnoses were given of en plaque meningioma , subdural hematoma with a hidden vascular malformation , and possibly intradural extramedullary tuberculoma .
given the radiologic findings , indolent course of symptom , and the past medical history , a long - term sequela of tuberculoma should be considered as a diagnosis .
the evidence of a progressive pulmonary tb was not found on the x - ray and ct in the chest , which designated old calcified scars in the right upper lung field .
acid - fast bacilli ( afb ) of sputum stain and culture were all negative for mycobacterium tuberculosis .
the analysis of cerebrospinal fluid ( csf ) did not indicate specific findings ( protein 46.3 , glucose 73 , rbc 13 , wbc 3 , poly 0% , lymph 0% ) .
therefore , the lesion was suspected of a chronic inactive fibrotic scar with calcification . during the operation
there was a clear dissection plane between the mass and the spinal cord except in the stalk portion of the mass .
the stalk was firmly connected with the pial surface and showed the hard consistency due to calcification .
the fibrotic mass was removed with the spinal cord detached completely from the stalk portion of the mass .
however , motor evoked potentials had not been detected during surgery due to technical problems .
pathologic analysis reported the chronic granulomatous inflammation with caseous necrosis , suspicious for tuberculosis ( fig .
one month after the surgery , he did not complain the gait abnormality and urinary difficulty any more .
tuberculosis is diagnosed definitely by identifying the causative organism(mycobacterium tuberculosis ) in a clinical sample . when this is not possible
, a probable diagnosis may be made using imaging , a tuberculin skin test ( mantoux test ) , a molecular diagnostic test like polymerase chain reaction ( pcr ) assays for the detection of bacterial dna , or a serologic test such as interferon gamma release assay ( igra ) .
all the evidences such as the past medial history , results of afb stain and culture in csf and sputum , radiological findings , and pathological results suggested that the diagnosis was the chronic sequela of tuberculoma without infectivity . according to previous reports , intradural extramedullary tuberculomas are usually associated with tb meningitis12,14 ) .
this disease seems to also affect young people more commonly and is associated with subacute spinal cord compression with motor and sensory findings that correspond to the level of the lesion . for the review of literatures ,
it is interesting to note that all the intradural extramedullary tuberculoma cases except two1,15 ) were identified after antituberculosis therapy was initiated .
the nature of this lesion remains in doubt , but previous reports postulated that the pathophysiology is a result of immunological reaction .
narita et al.18 ) reported a paradoxical worsening in up to 36% of patients with tuberculosis and aids following an antiretroviral therapy .
the most likely explanation is interplay between the host 's immune responses and the direct effects of mycobacterial products13 ) .
after chemotherapy controls active tb , host - immunosuppression due to tb resolves , and then hypersensitivity to the protein derivatives of mycobacteria causes a paradoxical immune response11 ) .
other possible pathophysiology of calcified tuberculomas was a long - term residual sequel of tuberculosis meningitis9 ) . even though anti - tb medication was not initiated , there were two reports with this intradural extramedullary tuberculoma1,15 ) although the insidious nature and the gradual progression of the intradural tuberculoma often result in delayed diagnosis6 ) , medical therapy still remains the mainstay of the treatment for tuberculomas , while it would seem most reasonable that localized lesions exhibiting pressure symptoms would be treated surgically . in our case , the patient had symptoms several months after anti - tb medications , but he did not undergo further spinal evaluation such as mr imaging at that time because he was followed up in a small public clinic . as his symptoms were mainly insidious sensory symptoms , he could have maintained his work .
the cause of progressive thoracic myelopathy occurring five years later was likely to be a mechanical cord compression by a dynamic motion .
one of the possible explanations of a good outcome is that main symptom was related to the mechanical compression by the old scar tissue without inflammatory changes .
another possible cause was that the symptom was not motor weakness but sensory dysfunction indicating the involvement of the dorsal column of spinal cord .
three previous cases10,16,23 ) of poor outcome were mainly motor symptoms for more than one month .
the third possible cause was the presence of clear dissection plane which enabled to be separated from the spinal cord .
given the recent increasing incidence of tuberculosis , the clinician should be aware of its many manifestations , including extrapulmonary disease .
although an intradural extramedullary tuberculoma is a rare entity , it should be included in the differential diagnosis of subacute or chronic spinal cord compression in a relatively young patient with the history of pulmonary tb or tuberculous meningitis .
it is also noticed that a paradoxical reaction may occur after the initiation of anti - tb medication .
although medical therapy remains the mainstay of the treatment for tuberculomas , surgical resection will enhance the possibility for a successful outcome if myelopathic symptoms occur .
intradural extramedullary tuberculoma should be considered in the differential diagnosis of subacute or chronic spinal cord compression in a relatively young patient with the history of pulmonary tb or tb meningitis
. a fibrotic mass , which resulted from the long - term sequel of tuberculosis , can be resected .
depending on patient 's clinical symptoms and the degree of adhesion to the spinal cord , a favorable outcome can be anticipated .
a 45-year old man , who had tuberculosis five years ago presented with paresthesia , decreased proprioception , and gait disturbance in the lower extremity which were aggravated for a month . 
 magnetic resonance imaging revealed the t3 - 7 intradural extramedullary fibrotic mass with dark signal intensity on t2-weighted images . 
 the yellowish material in the thick fibrous mass was confirmed as caseous necrosis . 
 two days after the operation , the symptoms improved . 
 although quite rare , intradural extramedullary tuberculoma should be considered as a chronic sequel of the previous medical history of pulmonary tuberculosis or tuberculous meningitis .