You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["RNA", "CellLine", "Protein", "DNA", "CellType"].

Please return the output as a JSON object of the format: {"DNA" : ["TAL1", ...], "RNA": ["mRNAs", ...], "CellLine": ["T cells", ...], "CellType": ["monocytes", ...], "Protein": ["IL-2", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

The Epstein-Barr virus nuclear antigen 2 interacts with an EBNA2 responsive cis-element of the terminal protein 1 gene promoter. The Epstein-Barr virus protein EBNA2 acts as a transcriptional activator of cellular and viral genes and plays a crucial role in the immortalization of human primary B-cells by EBV. We have shown previously that EBNA2 transactivates the promoters of the latent membrane antigens LMP, TP1 and TP2. The promoter of the TP1 gene was chosen as a model system to study the molecular mechanism of EBNA2 mediated transactivation. To identify an EBNA2 dependent cis-acting element, various TP1 promoter-reporter gene constructs were transfected in the absence and presence of an EBNA2 expression vector into the established B-cell line BL41-P3HR1. We were able to delineate an 81 bp EBNA2 responsive region between-258 and-177 relative to the TP1 RNA start site. The element worked in either orientation and could mediate EBNA2 dependent transactivation on a heterologous promoter. Electrophoretic mobility shift assays revealed three specific protein-DNA complexes formed with sequences of the EBNA2 responsive element. Two of these were not cell type specific, but the third was detected only in EBNA2 positive cell extracts. Gel-shift analysis in the presence of EBNA2 specific monoclonal antibodies revealed that EBNA2 is a component of the third complex. Thus, these experiments demonstrate that EBNA2 interacts with an EBNA2 responsive cis-element of the TP1 promoter
{"CellLine": ["B - cell line BL41 - P3HR1"], "CellType": ["human primary B - cells"], "DNA": ["cellular and viral genes", "heterologous promoter", "EBNA2 responsive cis - element", "TP1 RNA start site", "EBNA2 expression vector", "TP1", "EBNA2 responsive element", "EBNA2 dependent cis - acting element", "81 bp EBNA2 responsive region", "TP1 gene", "promoter", "TP1 promoter - reporter gene constructs", "terminal protein 1 gene promoter", "TP1 promoter"], "Protein": ["Epstein - Barr virus nuclear antigen 2", "EBNA2", "Epstein - Barr virus", "TP1", "transcriptional activator", "EBNA2 specific monoclonal antibodies", "LMP", "TP2", "latent membrane antigens", "Epstein - Barr virus protein EBNA2", "protein - DNA complexes"], "RNA": []}