You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["HealthCareActivity", "InjuryOrPoisoning", "BodySubstance", "IntellectualProduct", "AnatomicalStructure", "SpatialConcept", "Chemical", "Bacterium", "MedicalDevice", "Organization", "BiomedicalOccupationOrDiscipline", "Finding", "BiologicFunction", "Virus", "ResearchActivity", "ClinicalAttribute", "PopulationGroup", "Eukaryote", "BodySystem", "Food", "ProfessionalOrOccupationalGroup"].

Please return the output as a JSON object of the format: {"Virus": ["HIV", ...], "Bacterium": ["MRSA", ...], "AnatomicalStructure": ["Lung", ...], "BodySystem": ["CNS", ...], "BodySubstance": ["Serum", ...], "Finding": ["Headache", ...], "InjuryOrPoisoning": ["Fracture", ...], "BiologicFunction": ["Death", ...], "HealthCareActivity": ["Biopsy", ...], "ResearchActivity": ["Clinical trial", ...], "MedicalDevice": ["Lenses", ...], "SpatialConcept": ["Camps", ...], "BiomedicalOccupationOrDiscipline": ["Forensic medicine", ...], "Organization": ["WHO", ...], "ProfessionalOrOccupationalGroup": ["Provider", ...], "PopulationGroup": ["Swimmers", ...], "Chemical": ["Gold", ...], "Food": ["Rice", ...], "IntellectualProduct": ["RPAM", ...], "ClinicalAttribute": ["Biomarker", ...], "Eukaryote": ["Dogs", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Evaluation of the VIDAS Anti-HCV Assay for Detection of Hepatitis C Virus Infection Anti-hepatitis C virus antibody (anti-HCV) assays are recommended for screening HCV -infected persons. The VIDAS Anti-HCV Assay (bioMérieux, France), based on the enzyme-linked fluorescence test principle, was recently introduced in Korea. We evaluated the clinical performance of the VIDAS assay. One hundred HCV-positive and 1,002 HCV-negative blood samples confirmed by Architect anti-HCV (Abbott Laboratories, USA) and COBAS TaqMan HCV real-time PCR (Roche Diagnostics, USA) or the Procleix Ultrio Plus Assay (Gen-Probe Incorporated, USA) were obtained from the Human Serum Bank (HSB) and tested by VIDAS. In case of discrepant results, we conducted a recombinant immunoblot assay (RIBA). The agreement rates for known HCV-positive and HCV-negative samples between the VIDAS assay and the HSB testing were 100% (95% confidence interval [CI]: 96.4-100%) and 99.5% (95% CI: 98.8-99.8%), respectively. One of the five discrepant samples was positive for Core 2+ and NS3-2 2+ reactivity, two samples were negative, and the other two were indeterminate regarding NS4 2+ reactivity in RIBA. We observed a significant but weak positive correlation between the titers of VIDAS and Architect assays (r=0.315, P<0.001). The VIDAS anti-HCV assay, developed on the VIDAS automated immunoassay platform based on the ready-to-use, single-sample test concept may be useful in small-to-medium-sized laboratories. It showed good agreement with Architect anti-HCV and COBAS PCR assays and is therefore useful for detection of HCV infection. Weakly test-positive (ambiguous) samples require additional testing by another anti-HCV, RIBA, or HCV RNA assay.
{"AnatomicalStructure": [], "Bacterium": [], "BiologicFunction": ["Hepatitis C Virus Infection", "HCV infection"], "BiomedicalOccupationOrDiscipline": [], "BodySubstance": ["samples", "blood samples"], "BodySystem": [], "Chemical": ["Anti-hepatitis C virus antibody", "anti-HCV", "NS4 2+", "NS3-2 2+", "Core 2+"], "ClinicalAttribute": [], "Eukaryote": [], "Finding": ["HCV-positive", "negative", "discrepant", "positive", "HCV-negative", "Weakly test-positive (ambiguous)", "discrepant results"], "Food": [], "HealthCareActivity": ["automated immunoassay platform", "assays", "Architect assays", "VIDAS anti-HCV assay", "VIDAS assay", "RIBA", "Detection", "screening", "HCV RNA assay", "Architect anti-HCV", "Evaluation", "recombinant immunoblot assay", "enzyme-linked fluorescence test", "VIDAS Anti-HCV Assay", "Procleix Ultrio Plus Assay"], "InjuryOrPoisoning": [], "IntellectualProduct": [], "MedicalDevice": [], "Organization": ["Roche Diagnostics", "laboratories"], "PopulationGroup": ["HCV -infected persons"], "ProfessionalOrOccupationalGroup": [], "ResearchActivity": ["COBAS PCR assays", "COBAS TaqMan HCV real-time PCR"], "SpatialConcept": ["Korea", "France", "USA"], "Virus": ["HCV"]}