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pyoderma gangrenosum ( pg ) is a rare inflammatory disease of the skin often associated with systemic inflammatory disease or immunodeficiency .
although rare , it is known to occur following trauma or operative procedures . to date nine cases
we report a delayed presentation of pg in a patient undergoing mitral valve replacement who was discharged home on postoperative day seven with a normal healing incision and presented two days later with a necrotic - appearing lesion which was later diagnosed as pg .
his prior medical history included repair of a cleft palate and a heart murmur . on admission ,
echocardiogram revealed severe mitral regurgitation with a flail and ruptured posterior mitral leaflet , a patent foramen ovale , pulmonary hypertension , and a markedly dilated left atrium without any vegetations .
mitral valve repair and closure of patent foramen ovale were undertaken via a median sternotomy utilizing a short skin incision .
his recovery was uneventful , and he was discharged home on postoperative day seven with a normal healing incision .
physical examination revealed a stable but alarmingly swollen sternal wound with necrotic margins along the entire length ( fig .
the patient was afebrile and hemodynamically stable but was admitted with a presumed wound infection and was started on intravenous vancomycin and cefepime .
laboratory work demonstrated a normal white blood cell count of 8.7 , elevated c - reactive protein of 8.8  mg / dl ( normal : 0.01.0 ) , and an elevated erythrocyte sedimentation rate of 44  mm / h ( normal : 013 ) . the following day , his two chest tube sites demonstrated similar lesions .
the wounds failed to improve , and after three days of antibiotics , the sternal wound was opened at the bedside and negative pressure wound therapy was initiated .
similar lesions blossomed at the sites of previous internal jugular line and subcutaneous heparin injection . on hospital day five , the patient was taken to the operating room for debridement .
interestingly , the wound demonstrated minimal purulence , a healing sternum , and persistent superficial necrosis .
all sternal wound cultures remained negative ; however , the chest tube wound grew methicillin - resistant staphylococcus aureus . due to the lack of response to debridement and antibiotics ,
an 8-mm punch biopsy demonstrated granulation tissue with detached acute inflammatory exudate and marked reactive change ( fig .
a diagnosis of pyoderma gangrenosum was made , and the patient was started on oral prednisone 80  mg daily .
prednisone was slowly tapered starting ten days after initiation , and the patient was discharged home on a tapering dose of oral steroids .
the diagnosis of pg in a postoperative setting is difficult as the wound may mimic an infection .
in fact , a recent case report shows a death resulting from pg when the disease involved the saphenous vein graft . to date ,
all ten case reports of pg after cardiac surgery have occurred in the initial week postoperatively ( table 1 ) .
what makes our case unique is the delayed presentation ( postoperative day nine ) , just 2 days after he was discharged with a seemingly normal healing wound .
the clinical challenge in pg involves ( 1 ) making a prompt diagnosis and ( 2 ) choosing the appropriate treatment .
pg in the postoperative period should be considered when the characteristic ulcerative lesions are seen diffusely in all surgical wounds and show minimal improvement with antibiotic treatment or debridement .
this was the case in our patient , who presented with necrotic lesions not only all along on his sternotomy wound , but also involving his chest tube sites and his central venous catheter site .
these did not show any improvement after a course of antibiotics nor after debridement in the operating room . once suspected , prompt dermatology consultation and skin biopsy aids in confirming the diagnosis .
the second challenge is selecting the appropriate treatment as there is no established standard . in previous reports of pg after cardiac surgery ,
treatments with prednisone , cyclosporine a , or a combination of both have been successful .
our patient was treated with a course of oral prednisone alone and showed rapid and marked improvement .
although the pathology of pg is not infectious , the lesions compromise the skin barrier significantly , and pg is known to be associated with an underlying immuno - deficient state . in our patient , antibiotics were administered for a presumed wound infection .
in fact , one of the wounds from our patient grew methicillin - resistant staphylococcus aureus . while there is no evidence to initiate antibiotics , we do recommend coverage for super - infection
in conclusion , pg is a rare complication after cardiac surgery , yet an important entity to recognize as prompt diagnosis is necessary to initiate appropriate treatment .
while all other reported cases have occurred within the first week of postoperative period , our case demonstrates that pg can present in a delayed fashion .
pg should be suspected when ulcerative lesions appear acutely and diffusely in all surgical wounds and respond minimally to debridement and antibiotic treatment .
dh was involved in study design and writing.key learning pointspyoderma gangrenosum can occur following cardiac surgery and can mimic wound infection.making the clinical distinction between pyoderma gangrenosum and wound infection is very important as the treatment is different . pyoderma gangrenosum can occur following cardiac surgery and can mimic wound infection.making the clinical distinction between pyoderma gangrenosum and wound infection is very important as the treatment is different .
pyoderma gangrenosum can occur following cardiac surgery and can mimic wound infection . making the clinical distinction between pyoderma gangrenosum and wound
introductionpyoderma gangrenosum ( pg ) is a rare , ulcerative inflammatory skin pathology frequently associated with systemic inflammatory disease . while rare after surgery , recognition of this disease in the post - surgical setting is important as it can mimic wound infection . 
 there have been ten case reports to date of pg occurring immediately after cardiac surgery , with all of them presenting within the first week post-operatively.presentation of casewe herein present a delayed and dramatic presentation of pg nine days after mitral valve replacement and repair of patent foramen ovale , two days after being discharged with a seemingly normal healing wound . 
 diagnosis of this disease in the postoperative period requires high suspicion when the characteristic ulcerative lesions are seen diffusely in all surgical wounds and show minimal improvement with antibiotic treatment or debridement.discussion/conclusionour case highlights the importance of recognizing this disease in the postoperative period , even in a delayed presentation and initially limited to one of the surgical sites . 
 this case calls for an awareness of this disease entity amongst cardiac surgeons as well as intensivists .