You will be shown inclusion or exclusion criteria for a clinical trial. Given these criteria, your task is to extract all unique entities of the following types: ["Observation", "Condition", "Procedure", "Drug", "Temporal", "Multiplier", "Qualifier", "Negation", "ReferencePoint", "Scope", "Value", "Mood", "Device", "Visit", "Measurement", "Person"].

Please return the output as a JSON object of the format: {"Condition" : ["breast cancer", ...], "Device" : ["ports", ...], "Drug" : ["Atenolol", ...], "Measurement" : ["blood pressure", ...], "Mood" : ["suspected", ...], "Multiplier" : ["more than two", ...], "Negation" : ["no", ...], "Observation" : ["history", ...], "Person" : ["male", ...], "Procedure" : ["surgery", ...], "Qualifier" : ["severe", ...], "ReferencePoint" : ["enrollment", ...], "Scope" : ["infection", ...], "Temporal" : ["one day", ...], "Value" : ["50%", ...], "Visit" : ["ICU", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Type of subject: outpatient. 
Informed consent: Subjects must give their signed and dated written informed consent to participate. 
Gender: Male or female. Female subjects must be post-menopausal or using a highly effective method for avoidance of pregnancy. The decision to include or exclude women of childbearing potential may be made at the discretion of the investigator in accordance with local practice in relation to adequate contraception. 
Age: >=40 and <=80 years of age at Screening (Visit 1). 
Tobacco use: Subjects with a current or prior history of >=10 pack-years of cigarette smoking at screening (Visit 1). Previous smokers are defined as those who have stopped smoking for at least 6 months prior to Visit 1. 
Airflow Obstruction: 
Subjects with a measured post-albuterol/salbutamol forced expiratory volume in 1 second (FEV1)/(forced vital capacity)FVC ratio of <=0.70 at Screening (Visit 1). 
Subjects with a measured post-albuterol/salbutamol FEV1 >=50 and <=70% of predicted normal values calculated using NHANES III reference equations [Hankinson, 1999; Hankinson, 2010] at Screening (Visit 1). 
Post-bronchodilator spirometry will be performed approximately 15 minutes after the subject has self-administered 4 inhalations (i.e., total 400mcg) of albuterol/salbutamol via a metered dose inhaler (MDI )with a valved-holding chamber. The FEV1/FVC ratio and FEV1 percent predicted values will be calculated. 
Symptoms of COPD: Subjects must score 2 or higher on the modified Medical Research Council Dyspnea scale (Visit 1) 
Cardiovascular disease: 
For patients >= 40 years of age: any one of the following: 
Established (i.e. by clinical signs or imaging studies) coronary artery disease (CAD) Established (i.e. by clinical signs or imaging studies) peripheral vascular disease (PVD) Previous stroke Previous MI Diabetes mellitus with target organ disease OR 
For patients >=60 years of age: any 2 of the following: 
Being treated for hypercholesterolemia Being treated for hypertension Being treated for diabetes mellitus Being treated for peripheral vascular disease
{"Condition": ["target organ disease", "peripheral vascular disease", "Previous smokers", "Diabetes mellitus", "diabetes mellitus", "hypercholesterolemia", "Symptoms of COPD", "peripheral vascular disease (PVD)", "coronary artery disease (CAD)", "hypertension", "stroke", "MI"], "Device": [], "Drug": ["bronchodilator", "salbutamol", "albuterol"], "Measurement": ["modified Medical Research Council Dyspnea scale", "FEV1", "forced expiratory volume in 1 second (FEV1)/(forced vital capacity)FVC ratio"], "Mood": [], "Multiplier": ["400mcg", "4", "\u003e=10 pack-years"], "Negation": [], "Observation": ["cigarette smoking", "Established", "stopped smoking", "history", "clinical signs"], "Person": ["Age", "age", "Male", "female"], "Procedure": ["metered dose inhaler (MDI )", "inhalations", "spirometry", "imaging studies", "treated for hypertension", "treated for diabetes mellitus", "treated for peripheral vascular disease", "treated for hypercholesterolemia"], "Qualifier": ["Post-bronchodilator", "with a valved-holding chamber", "post-albuterol/salbutamol", "using NHANES III reference equations", "self-administered"], "ReferencePoint": ["albuterol/salbutamol", "bronchodilator", "Screening", "Visit 1"], "Scope": ["current or prior", "albuterol/salbutamol", "clinical signs or imaging studies", "stopped smoking for at least 6 months prior to Visit 1"], "Temporal": ["current", "Post-bronchodilator", "Previous", "prior", "post-albuterol/salbutamol", "at screening", "for at least 6 months prior to Visit 1", "approximately 15 minutes after", "at Screening"], "Value": ["\u003e=40 and \u003c=80 years", "\u003e=50 and \u003c=70% of predicted normal values", "\u003e= 40 years", "\u003e=60 years", "score 2 or higher", "\u003c=0.70"], "Visit": ["outpatient"]}