You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["RNA", "CellLine", "Protein", "DNA", "CellType"].

Please return the output as a JSON object of the format: {"DNA" : ["TAL1", ...], "RNA": ["mRNAs", ...], "CellLine": ["T cells", ...], "CellType": ["monocytes", ...], "Protein": ["IL-2", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Transactivation of the human immunodeficiency virus promoter by human herpesvirus 6 (HHV-6) strains GS and Z-29 in primary human T lymphocytes and identification of transactivating HHV-6 (GS) gene fragments. Human herpesvirus 6 (HHV-6) can activate the human immunodeficiency virus (HIV) promoter and accelerate cytopathic effects in HIV-infected human T cells. This study examines the regions of the HIV promoter required for HHV-6 transactivation in a heterogeneous population of primary human T lymphocytes with or without antigenic stimulation. Two different strains of HHV-6, GS and Z29, transactivated the HIV promoter. The GS strain transactivated the promoter in both stimulated and resting T cells, while the Z29 strain increased HIV promoter activity only in stimulated T cells. Three DNA clones containing HHV-6 (GS) genomic fragments transactivated the HIV promoter in cotransfected T cells. A 21. 4-kb DNA clone, pZVB70, showed the highest transactivating ability, while two other DNA fragments, pZVB10 (6. 2 kb) and pZVH14 (8. 7 kb), showed lower activity. One of these clones, pZVH14, activated the HIV promoter construct containing a mutation in the NF kappa B site. However, this mutated NF kappa B promoter was not transactivated during HHV-6 (GS) infection or after cotransfection with pZVB70 or pZVB10. These data indicate that the NF kappa B sites of the HIV promoter are essential for its transactivation during HHV-6 (GS) infection. By increasing HIV promoter activity in primary T lymphocytes, HHV-6 may consequently increase HIV replication, leading to an increase in the cytopathic effect on coinfected human T cells.
{"CellLine": ["cotransfected T cells"], "CellType": ["primary human T lymphocytes", "lymphocytes", "coinfected human T cells", "stimulated T cells", "primary T lymphocytes", "T cells", "HIV - infected human T cells"], "DNA": ["HIV promoter construct", "HHV - 6 (GS) genomic fragments", "pZVH14", "pZVB70", "DNA fragments", "pZVB10", "transactivating HHV - 6 (GS) gene fragments", "human immunodeficiency virus promoter", "promoter", "mutated NF kappa B promoter", "GS", "NF kappa B site", "NF kappa B sites", "human immunodeficiency virus (HIV) promoter", "HIV promoter", "21 . 4 - kb DNA clone"], "Protein": [], "RNA": []}