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polyvinyl pyrrolidone(pvp k 30 ) and dimethyle sulfoxide ( dmso ) were purchased from himedia and merck respectively .
all the other reagents were of analytical grade and purchased from loba chem . and himedia .
rpm the prepared drug solution was injected drop wise into water containing pvp k 30(0.05%,0.1%,0.2%,0.4%w / v ) immediately , particles precipitated from the antisolvent and a milk - like suspension formed which was than filtered and dried .
powder dissolution study was carried out by using usp apparatus ii(paddle)(model : tdt-08l , make : electrolab , india ) , dissolution media was 900 ml of 0.1 n hcl at a temperature of 370.5 c at 50 rpm .
4ml of dissolution medium was withdrawn at regular time intervals ( 5,10,15,30,45,60,90minutes ) and filtered and 4ml of 0.1n hcl was added to jar .
absorbance of the resultant solution was measured by ultra violet spectrophotometer ( model : uv- 1800 make : shimadzu ) at 307.8 nm using 0.1n naoh as a blank .
particle size was measured by dynamic light scattering technique using particle size analyser ( model : nanos90 make : malvern , usa ) .
x - ray diffraction analysis was carried out for pure drug and prepared nanocrystals using x - ray diffractometer ( model : d2 phaser make : bruker , usa ) .
polyvinyl pyrrolidone(pvp k 30 ) and dimethyle sulfoxide ( dmso ) were purchased from himedia and merck respectively .
all the other reagents were of analytical grade and purchased from loba chem . and himedia .
rpm the prepared drug solution was injected drop wise into water containing pvp k 30(0.05%,0.1%,0.2%,0.4%w / v ) immediately , particles precipitated from the antisolvent and a milk - like suspension formed which was than filtered and dried .
powder dissolution study was carried out by using usp apparatus ii(paddle)(model : tdt-08l , make : electrolab , india ) , dissolution media was 900 ml of 0.1 n hcl at a temperature of 370.5 c at 50 rpm .
4ml of dissolution medium was withdrawn at regular time intervals ( 5,10,15,30,45,60,90minutes ) and filtered and 4ml of 0.1n hcl was added to jar .
absorbance of the resultant solution was measured by ultra violet spectrophotometer ( model : uv- 1800 make : shimadzu ) at 307.8 nm using 0.1n naoh as a blank .
particle size was measured by dynamic light scattering technique using particle size analyser ( model : nanos90 make : malvern , usa ) .
x - ray diffraction analysis was carried out for pure drug and prepared nanocrystals using x - ray diffractometer ( model : d2 phaser make : bruker , usa ) .
albendazole nanocrystals was prepared using different concentration of pvp k 30 and characterized with respect to particle size , in vitro dissolution and x - ray diffraction pattern .
results of particle size and % drug release at 30 minute ( q30 min ) and 60 minute ( q60 min ) for unmilled drug and different batches of albendazole nanocrystals were described in table 1 .
dissolution profile and xrd pattern of unmilled drug and prepared albendazole nanocrystals were shown in figures 1 and 2 respectively . particle size and % drug release at 30 minute ( q30 min ) and 60 minute ( q60 min ) for unmilled drug and different batches of albendazole nanocrystals dissolution profile of unmilled drug and different batches of albendazole nanocrystals xrd pattern of unmilled drug and albendazole nanocrystals ( pvp k 30 ( 0.4% ) )
nanocrystals produced using pvp k 30 showed high dissolution rate as compared to unmilled drug .
enhancement of dissolution rate observed with increase in pvp k 30 concentration may be attributed to reduction in particle size and improvement in wetting of particles .
comparison of x - ray diffraction pattern of unmilled drug and nanocrystals indicate that for nanocrystals reduction in peak intensity takes place but peak position remains the same
albendazole , a bcs class ii drug , has poor dissolution characteristic . in order to enhance dissolution nanocrystals 
 were prepared by antisolvent precipitation process using pvp k-30(0.05%,0.1%,0.2%,0.4% ) as stabilizer . 
 the process was optimized in terms of concentration of stabilizer(pvp k 30 ) in order to enhance dissolution and obtain stable particles with a small mean particle size . 
 nanocrystals were characterized with respect to particle size , in vitro dissolution and x - ray diffraction pattern . 
 decrease in particle size of nanocrystals was observed with increase in concentration of stabilizer . 
 dissolution of nanocrystals also improved with increase in concentration of pvp k-30 . 
 crystalline state evaluation before and following particle size reduction was conducted through xrd to denote any possible transformation to an amorphous state during process .