You will be presented with a collection of medical randomized controlled trial (RCT) reports addressing a shared clinical question -- for instance, the efficacy of a medical intervention on a disease or condition. Given the titles and abstracts of these reports, your task is to generate the conclusion of the systematic review article synthesizing the key findings. Your conclusion should be a few sentences long. In your response, include only the conclusion and no other text. The RCT reports are below.



Title 1:
TERT promoter mutations: a novel independent prognostic factor in primary glioblastomas.
Abstract 1:
BACKGROUND Activating somatic mutations in the promoter region of the telomerase reverse transcriptase gene ( TERT ) have been detected in several cancers . In this study we investigated the TERT promoter mutations and their impact on  patient survival in World Health Organization grade IV glioblastoma multiforme ( GBM ) . METHODS The TERT core promoter region containing the previously described mutations and a common functional polymorphism ( rs2853669 ) was sequenced in tumors and blood sample s from 192 GBM patients . O(6)-methylguanine-DNA methyltransferase ( MGMT ) promoter methylation status was assessed by pyrosequencing in 177 ( 92.2 % ) cases . Relevant clinical data were obtained from a prospect ively maintained electronic data base . RESULTS We detected specific ( -124 C > T and -146 C > T ) TERT promoter mutations in 143/178 ( 80.3 % ) primary GBM and 4/14 ( 28.6 % ) secondary GBM ( P < .001 ) . The presence of TERT mutations was associated with poor overall survival , and the effect was confined to the patients who did not carry the variant G-allele for the rs2853669 polymorphism . An exploratory analysis suggested that TERT mutations might be prognostic only in patients who had incomplete resections and no temozolomide chemotherapy . CONCLUSIONS In this study , specific TERT promoter mutations were markers of primary GBM and predicted patient survival in conjunction with a common functional polymorphism . The prognostic impact of TERT mutations was absent in patients with complete resections and temozolomide chemotherapy . If confirmed in additional studies , these findings may have clinical implication s , that is , TERT mutations appear to characterize tumors that require aggressive treatment


Title 2:
Telomerase Reverse Transcriptase (TERT) Gene Variations and Susceptibility of Colorectal Cancer.
Abstract 2:
AIM Colorectal cancer is the third most common cause of cancer-related mortality . Previous studies demonstrated increased telomerase activity in colorectal cancer tissue and suggested a prognostic value for patients with colorectal carcinoma .  Telomerase reverse transcriptase ( TERT ) , one of the main functional subunits of the telomerase , is an important factor in modulating telomerase activity , telomere length , and genomic stability . However , there are few studies that have addressed the association between genetic variation at TERT and the risk of colorectal cancer . METHOD We evaluated the influence of three common single-nucleotide polymorphisms ( SNPs ) of the TERT gene ( rs2853669 , rs2736100 , rs2736098 ) on  susceptibility to colorectal cancer in 104 patients and 135 controls in a Turkish population . RESULTS We observed that rs2736098 was significantly associated with increased risk of colorectal cancer ( OR = 2.53 ; 95 % CI = 1.26 - 5.10 ; p = 0.008 ) . On the other h and , rs2736100 and rs2853669 showed no association with colorectal cancer ( p ≥ 0.128 ) . CONCLUSION These findings are the first results of TERT allele distributions in the Turkish population and also provide increased underst and ing with respect to colorectal cancer etiology
Subsequent analyses also did not reveal any association between rs2853669 and overall cancer prognosis .
In conclusion , our findings suggest that rs2853669 could be important for assessing the prognostic value of TERTp mutations .