You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["Outcome", "Participant", "Intervention"].

Please return the output as a JSON object of the format: {"Participant" : ["patients with COPD", ...], "Intervention" : ["Atenolol", ...], "Outcome" : ["blood pressure", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Combined administration of nitric oxide gas and iloprost during cardiopulmonary bypass reduces platelet dysfunction : a pilot clinical study . BACKGROUND Thrombocytopenia and platelet dysfunction are major mechanisms of cardiopulmonary bypass-induced postoperative hemorrhage . This study evaluated the effects of low amounts of nitric oxide , iloprost ( prostacyclin analog ) , and their combination administered directly into the oxygenator on platelet function , platelet-leukocyte interactions , and postoperative blood loss in patients undergoing coronary artery bypass grafting . METHODS Blood samples from 41 patients randomized to the control , nitric oxide ( 20 ppm ) , iloprost ( 2 ng x kg -1 x min -1 ) , or nitric oxide plus iloprost groups were collected during cardiopulmonary bypass . Platelets and leukocytes were enumerated . Platelet membrane glycoprotein Ib and glycoprotein IIb/IIIa , P-selectin , platelet-derived microparticles , leukocyte CD11b/CD18 ( Mac-1 ) , and platelet-leukocyte aggregate were quantified by means of flow cytometry . Collagen and thrombin receptor-activating peptide-induced platelet aggregation in whole blood was analyzed by means of aggregometry . RESULTS Both nitric oxide or iloprost attenuated cardiopulmonary bypass-induced thrombocytopenia , reduction of glycoprotein Ib and glycoprotein IIb levels , translocation of P-selectin , microparticle formation , Mac-1 upregulation , and suppression of collagen-induced aggregation . Nitric oxide plus iloprost was significantly more effective in preventing thrombocytopenia , microparticle formation , and P-selectin translocation . Moreover , this treatment preserved thrombin receptor-activating peptide-induced aggregation , which was not rescued by single treatments . Both nitric oxide and nitric oxide plus iloprost attenuated postoperative blood loss . CONCLUSIONS Nitric oxide plus iloprost reduced the deleterious effects of cardiopulmonary bypass , such as thrombocytopenia , platelet activation , platelet-leukocyte aggregate formation , and suppression of platelet aggregative responses . The reduced postoperative bleeding observed with this treatment suggests that this is a new and clinically feasible therapeutic option for patients subjected to cardiopulmonary bypass .
{"Intervention": ["nitric oxide , iloprost ( prostacyclin analog )", "nitric oxide gas and iloprost", "nitric oxide plus iloprost", "nitric oxide", "iloprost"], "Outcome": ["platelet-leukocyte aggregate", "Platelet membrane glycoprotein Ib", "glycoprotein Ib", "P-selectin", "Mac-1 upregulation", "collagen-induced aggregation .", "P-selectin translocation", "glycoprotein IIb levels", "glycoprotein IIb/IIIa , P-selectin , platelet-derived microparticles , leukocyte CD11b/CD18 ( Mac-1 )", "thrombocytopenia", "blood loss .", "platelet-leukocyte aggregate formation", "platelet aggregative responses", "microparticle formation", "platelet activation"], "Participant": ["41", "cardiopulmonary bypass", "coronary artery bypass"]}