You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["Outcome", "Participant", "Intervention"].

Please return the output as a JSON object of the format: {"Participant" : ["patients with COPD", ...], "Intervention" : ["Atenolol", ...], "Outcome" : ["blood pressure", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Hepatic cytoprotective effect of ischemic and anesthetic preconditioning before liver resection when using intermittent vascular inflow occlusion : a randomized clinical trial . BACKGROUND Ischemic preconditioning ( IPC ) and anesthetic preconditioning ( APC ) have been reported to attenuate ischemia-reperfusion ( IR ) injury after liver resection under continuous inflow occlusion . This study evaluates whether these strategies enhance hepatic protection of remnant liver against IR after liver resection with intermittent clamping ( INT ) . METHODS A total of 106 patients without underlying liver disease and submitted to liver resection using INT were randomized into 3 groups : IPC ( 10 minutes of inflow occlusion followed by 10 minutes of reperfusion before liver transection ) , APC ( sevoflurane administration for 20 minutes before liver transection ) , and INT ( no preconditioning ) . Patients were also stratified according to the extent of the hepatectomy . Cytoprotection was evaluated by comparing hepatocyte and endothelial dysfunction markers , apoptosis , histologic lesions , and postoperative outcome . RESULTS No differences were observed in preoperative chemotherapy and steatosis , total warm ischemia time , operative time , or blood loss . Kinetics of transaminases ( aspartate aminotransferase , P = .137 ; alanine aminotransferase , P = .616 ) , bilirubin ( P = .980 ) , and hyaluronic acid increase ( P = .514 ) revealed no differences . Significant apoptosis was present in 40 % of patients , mild-to-moderate leukocyte infiltration and steatosis in 45 % and 55 % , respectively , and mild sinusoidal congestion in 65 % , with a similar distribution in the 3 groups . When patients were stratified by major versus minor resections , no differences were observed in any of the variables studied . Postoperative clinical outcomes were also similar . CONCLUSION These results suggest that these protocols of IPC and APC used in this study do not provide better cytoprotection from IR when INT is used .
{"Intervention": ["ischemic", "anesthetic preconditioning", "APC", "IPC ( 10 minutes of inflow occlusion followed by 10 minutes of reperfusion before liver transection )", "IPC", "INT", "intermittent clamping ( INT )", "anesthetic preconditioning ( APC )", "INT ( no preconditioning )", "APC ( sevoflurane administration for 20 minutes before liver transection )", "Ischemic preconditioning ( IPC )"], "Outcome": ["mild-to-moderate leukocyte infiltration and steatosis", "Significant apoptosis", "comparing hepatocyte and endothelial dysfunction markers , apoptosis , histologic lesions , and postoperative outcome", "mild sinusoidal congestion", "Cytoprotection", "bilirubin", "hyaluronic acid", "preoperative chemotherapy and steatosis , total warm ischemia time , operative time , or blood loss", "Kinetics of transaminases"], "Participant": ["liver disease", "106 patients", "liver resection with intermittent clamping ( INT )"]}