You are presented with a paragraph from a COVID-19 literature. Classify the topics of this piece of text by choosing from the following categories:

- Epidemic Forecasting: The content relates to predictions about the spread of COVID-19.
- Treatment: The paragraph discusses therapeutic methods or medication for COVID-19.
- Prevention: The content covers measures to prevent the spread of COVID-19.
- Mechanism: The paragraph explains the biological mechanisms of the virus.
- Case Report: The content is a report of a COVID-19 case.
- Transmission: The paragraph discusses how COVID-19 is transmitted.
- Diagnosis: The content is about diagnosing COVID-19 in individuals.

Your classification should be provided as an element within a JSON array. The array should be formatted with topics enclosed in double quotes and separated by commas, following the JSON format, for example: ["Topic1", "Topic2", ...]. Include all applicable topics within the array. Your output should be a valid JSON array, and no additional text should be included in your response.

Article:

Background: The role of high-flow nasal cannula (HFNC) and CPAP in COVID-19 are controversial. The objective of the study was to evaluate the impact of the application of a non-invasive respiratory support (NIRS) algorithm on clinical outcomes in COVID-19 subjects with acute respiratory failure (ARF).Methods: We performed a single center prospective observational study of subjects with respiratory failure from COVID-19 managed with high-flow nasal cannula (HFNC) and CPAP+HFNC (combined therapy). The main outcome was the intubation rate, which defined failure of therapy. We also analyzed the role of the ROX index ([SpO2/FiO2]/respiratory rate) to predict the need for intubation.Results: From June to December 2020, 113 subjects with COVID-19 respiratory failure were admitted to our respiratory intermediate care unit (RICU). HFNC was applied in 65 subjects (57.52%) and combined therapy in 48 (42.47%). A total of 83 subjects (73.45%) were successfully treated with NIRS. The intubation rate was 26.54 %, and overall mortality was 14.15%. Mortality rate in intubated subjects was 55.2%. ROX index of 6.28 at 12 hours predicted NIRS failure, with 97.6% of sensitivity and 51.8% of specificity.Conclusions: Data from our cohort managed on RICU showed that combined NIRS are feasible with favorable outcomes. Further prospective studies are required.
["Treatment"]