You will be shown inclusion or exclusion criteria for a clinical trial. Given these criteria, your task is to extract all unique entities of the following types: ["Observation", "Condition", "Procedure", "Drug", "Temporal", "Multiplier", "Qualifier", "Negation", "ReferencePoint", "Scope", "Value", "Mood", "Device", "Visit", "Measurement", "Person"].

Please return the output as a JSON object of the format: {"Condition" : ["breast cancer", ...], "Device" : ["ports", ...], "Drug" : ["Atenolol", ...], "Measurement" : ["blood pressure", ...], "Mood" : ["suspected", ...], "Multiplier" : ["more than two", ...], "Negation" : ["no", ...], "Observation" : ["history", ...], "Person" : ["male", ...], "Procedure" : ["surgery", ...], "Qualifier" : ["severe", ...], "ReferencePoint" : ["enrollment", ...], "Scope" : ["infection", ...], "Temporal" : ["one day", ...], "Value" : ["50%", ...], "Visit" : ["ICU", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Use of investigational drugs either within 5 half-lives of enrollment, or within 30 days, or until the expected pharmacodynamic effect has returned to baseline, whichever is longer.
Major surgery in the last 3 months prior to baseline or planned major surgery or cardiac intervention during the study.
Cancer or other significant co-morbidities implying that the patient's condition is unstable.
Comorbidities that can be associated with elevated natriuretic peptide (NP) levels: renal insufficiency, (eGFR < 25 ml/min/1.73 m² calculated according to MDRD formula), recent (less than 3 months) cerebral trauma or recent (less than 3 months) cerebrovascular incident, novel diagnosis or acute exacerbation of COPD within the last 3 months.
Patients who are primarily managed and regularly followed-up by a cardiologist for their HF
Highly frail patients whose estimated lifespan due to comorbidities by the judgement of the investigator is less than 6 months.
{"Condition": ["acute exacerbation of COPD", "cerebrovascular incident", "cerebral trauma", "Comorbidities", "Cancer", "co-morbidities", "renal insufficiency"], "Device": [], "Drug": [], "Measurement": ["riuretic peptide (N els: r", "NP", "eGFR"], "Mood": [], "Multiplier": [], "Negation": [], "Observation": ["lifespan"], "Person": [], "Procedure": ["Major surgery"], "Qualifier": [], "ReferencePoint": ["baseline or planned major surgery or cardiac intervention during the stud"], "Scope": ["renal insufficiency, (eGFR \u003c 25 ml/min/1.73 m\u00b2 calculated according to MDRD formula), recent (less than 3 months) cerebral trauma or recent (less than 3 months) cerebrovascular incident, novel diagnosis or acute exacerbation of COPD within the last 3 months"], "Temporal": ["less than 3 months", "less than 6 months", "last 3 months", "last 3 months prior to baseline or planned major surgery or cardiac intervention during the study"], "Value": ["\u003c 25 ml/min/1.73 m\u00b2", "elevated"], "Visit": []}