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a 32-year - old korean woman found that she had visual loss in her right eye when she woke up in the morning and was referred to our clinic for acute crao 16 hours after symptom occurrence .
eight years prior , she had presented with itching and tender violaceous erythematous non - elevated patches with central necrotic vesicle on the dorsum of both the lower legs and feet ( fig .
1a and 1b ) the lesions were improved by colchicines 0.6 mg / day , hydroxyzine , and methylprednisolone 4 to 8 mg / day .
1c ) . a segmental limb pressure test with a bidirectional doppler test showed normal blood pressures in all four extremities
she was intermittently treated with pentoxifylline and mupirocin ointment for skin lesions for three years .
she was in good medical condition except for the skin lesions and had no experience of smoking .
she had one son and no history of spontaneous abortion . at presentation , her visual acuity was hand motion in the right eye and 20 / 20 in the left eye .
fundus examination of the right eye showed whitish edematous retina , a cherry - red spot , and narrowing and segmentation of retinal arteries suggesting acute crao ( fig .
2a ) laboratory test results , including rheumatological tests such as anti - nuclear antibody ; anti - ro and anti - la antibodies ; anti - neutrophil cytoplasmic antibody ; anti - dna antibodies ; rheumatoid factor ; cryoglobulin ; antithrombin activity ; protein c and s activity ; d - dimer ; anti - beta2-glycoprotein ; anticardiolipin antibody ; lupus anticoagulant ; prothrombin gene mutation ; factor v leiden gene mutation ; and homocysteine , were all within normal limits except for slightly elevated c - reactive protein ( 0.62 mg / dl ) and fibrinogen ( 425 mg / dl ) .
the serology tests were positive for hepatitis b antigen while other serology tests were normal .
she consented to receive intra - arterial thrombolysis after being informed of the possible risks and benefits of the intervention .
cerebral angiography showed severe focal vasospasm of the right internal carotid artery as soon as the catheter was placed ( fig .
3a ) , which was subsequently relieved by continuous intra - arterial infusion of nimodipine 5 mg .
selective angiography of the origin of the right ophthalmic artery showed no definite thrombus or steno - occlusive lesion within the ophthalmic artery ( fig .
the ophthalmic artery was infused with a fibrinolytic agent ( 500,000 units of urokinase ) until the maximal dose of fibrinolytics was reached as based on our protocol , but there was no visual improvement during the procedure .
seven hours after intra - arterial thrombolysis , retinal arterial perfusion on fundus fluorescein angiography ( ffa ) did not improve ( arm to retina time , 29 seconds ; arteriovenous transit time : about 4 minutes ) ( fig .
ffa three days after intra - arterial thrombolysis showed nearly complete restoration of retinal arterial perfusion ( arm to retina time , 17 seconds ; arteriovenous transit time , about 30 seconds ) with the exception of the macular area ( no reflow phenomenon ) .
six weeks after thrombolysis , her visual acuity remained hand motion and fundus photography showed severe retinal atrophy in the macula and disc pallor ( fig . 2c ) .
the patient in our case was in the extremely low risk group for crao in that she was very young and without any known risk factors such as diabetes , hypertension , renal disease , ischemic heart disease , cerebrovascular accidents , or smoking . according to a population - based study , crao occurs more often in older persons , with a mean age of 61.9 , but is relatively rare in young patients .
approximately 75% of cases of retinal arterial obstruction ( rao ) in patients over the age of 40 have findings suggestive of emboli originating from the carotid arteries
. however , young patients with rao rarely have artheromatous vascular diseases , but rather have more diverse etiologic factors . according to studies on rao in young patients ,
one or more systemic or ocular findings were identified in 85% and 91% of patients under the ages of 30 and 40 , respectively .
therefore , it is reasonable to conclude that lv was associated with the pathogenic mechanism of crao in our case , as lv is known to cause occlusion of the dermal vessels by intravascular fibrin , segmental hyalinization , and endothelial proliferation . to date , the pathogenesis of lv has not been fully elucidated .
lv has been reported to be associated with hypercoagulable disorders and/or autoimmune diseases , such as hyperhomocysteinemia , activated protein c resistance , factor v leiden mutation , elevated fibrinopeptide a levels , anticardiolipin antibodies , or defective release of tissue plasminogen activator [ 15 - 19 ] . to our knowledge , there have been no crao cases reported to be associated with lv . as crao
can be appropriately considered as a form of cerebrovascular lesion , our case may also be considered a variant of sneddon 's syndrome , which is characterized by generalized livedo reticularis and cerebrovascular lesion
. there have been 5 case reports of crao in sneddon 's syndrome , of which 3 were male and 2 were female , with an average age of 34.6 years ( range , 18 to 50 years ) [ 5 - 9 ] . among them , antiphospholipid antibody was tested in 4 cases , out of which 3 were positive and 1 was negative [ 5 - 9 ] .
antiphospholipid antibodies have been found in up to 80% of individuals with sneddon 's syndrome .
although there were no differences in clinical manifestations between the antibody - positive and negative groups , only the antiphospholipid antibody - positive patients could fulfill the diagnostic criteria for antiphospholipid antibody syndrome .
therefore , our case is the second case of crao in sneddon 's syndrome not associated with antiphospholipid antibodies . in comparison
with previously reported retinal artery occlusion in patients with sneddon 's syndrome , our case is distinguishable by the presence of skin ulceration and the lack of history of cerebrovascular accidents [ 5 - 8 ] as well as the absence of antiphospholipid antibodies . in conclusion , acute crao can occur in association with lv in middle - aged female patients and may be an atypical manifestation of sneddon 's syndrome .
livedoid vasculopathy ( lv ) is characterized by a long history of ulceration of the feet and legs and histopathology indicating a thrombotic process . 
 we report a case of acute central retinal artery occlusion in a 32-year - old woman who had lv . 
 she showed no discernible laboratory abnormalities such as antiphospholipid antibodies and no history of cerebrovascular accidents . 
 attempted intra - arterial thrombolysis showed no effect in restoring retinal arterial perfusion or vision . the central retinal artery occlusion accompanied by lv in this case 
 could be regarded as a variant form of sneddon 's syndrome , which is characterized by livedo reticularis and cerebrovascular accidents .