Given an abstract from a research paper, your task is to identify and label relationships between chemical compounds and genes mentioned in the abstract.

The relationship type must be one of ['DOWNREGULATOR', 'SUBSTRATE', 'INDIRECT-REGULATOR', 'PART-OF', 'MODULATOR-ACTIVATOR', 'REGULATOR', 'INHIBITOR', 'COFACTOR', 'UPREGULATOR', 'ACTIVATOR', 'ANTAGONIST', 'NOT', 'INDIRECT-DOWNREGULATOR', 'SUBSTRATE_PRODUCT-OF', 'INDIRECT-UPREGULATOR', 'AGONIST', 'PRODUCT-OF', 'MODULATOR', 'DIRECT-REGULATOR', 'UNDEFINED', 'AGONIST-INHIBITOR', 'AGONIST-ACTIVATOR', 'MODULATOR-INHIBITOR'].

Please format your output as a JSON array. Each entry in the array should express a single relation, formatted as ["<Entity_A>", "<RELATION_A_B>", "<Entity_B>"]. If no relations can be found, please output an empty JSON array [].

Abstract:

Functional characterization of alpha-adrenoceptors mediating pupillary dilation in rats. Previously, we reported that the alpha (1A) -adrenoceptor, but not the alpha (1D) -adrenoceptor, mediates pupillary dilation elicited by sympathetic nerve stimulation in rats. This study was undertaken to further characterize the alpha-adrenoceptor subtypes mediating pupillary dilation in response to both neural and agonist activation. Pupillary dilator response curves were generated by intravenous injection of norepinephrine in pentobarbital-anesthetized rats. Involvement of alpha (1) -adrenoceptors was established as mydriatic responses were inhibited by systemic administration of nonselective alpha-adrenoceptor antagonists, phentolamine (0.3-3 mg/kg) and phenoxybenzamine (0.03-0.3 mg/kg), as well as by the selective alpha (1) -adrenoceptor antagonist, prazosin (0.3 mg/kg). The alpha (2) -adrenoceptor antagonist, rauwolscine (0.5 mg/kg), was without antagonistic effects. alpha (1A) -Adrenoceptor selective antagonists, 2- ([2,6-dimethoxyphenoxyethyl]aminomethyl) -1,4-benzodioxane (WB-4101; 0.1-1 mg/kg) and 5-methylurapidil (0.1-1 mg/kg), the alpha (1B) -adrenoceptor selective antagonist, 4-amino-2-[4-[1- (benzyloxycarbonyl) -2 (S) - [ [ (1,1-dimethylethyl) amino]carbonyl]-piperazinyl]-6,7-dimethoxyquinazoline (L-765314; 0.3-1 mg/kg), as well as the alpha (1D) -adrenoceptor selective antagonist, 8-[2-[4- (2-methoxyphenyl) -1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione (BMY-7378; 1 mg/kg), were used to delineate the adrenoceptor subtypes involved. Mydriatic responses to norepinephrine were significantly antagonized by intravenous administration of both WB-4101 and 5-methylurapidil, but neither by L-765314 nor by BMY-7378. L-765314 (0.3-3 mg/kg, i.v.) was also ineffective in inhibiting the mydriasis evoked by cervical sympathetic nerve stimulation. These results suggest that alpha (1B) -adrenoceptors do not mediate sympathetic mydriasis in rats, and that the alpha (1A) -adrenoceptor is the exclusive subtype mediating mydriatic responses in this species.
[["4-amino-2-[4-[1- (benzyloxycarbonyl) -2 (S) - [ [ (1,1-dimethylethyl) amino]carbonyl]-piperazinyl]-6,7-dimethoxyquinazoline", "ANTAGONIST", "alpha (1B) -adrenoceptor"], ["5-methylurapidil", "ANTAGONIST", "alpha (1A) -Adrenoceptor"], ["WB-4101", "ANTAGONIST", "alpha (1A) -Adrenoceptor"], ["L-765314", "ANTAGONIST", "alpha (1B) -adrenoceptor"], ["2- ([2,6-dimethoxyphenoxyethyl]aminomethyl) -1,4-benzodioxane", "ANTAGONIST", "alpha (1A) -Adrenoceptor"], ["rauwolscine", "ANTAGONIST", "alpha (2) -adrenoceptor"], ["phentolamine", "ANTAGONIST", "alpha-adrenoceptor"], ["phenoxybenzamine", "ANTAGONIST", "alpha-adrenoceptor"], ["BMY-7378", "ANTAGONIST", "alpha (1D) -adrenoceptor"], ["8-[2-[4- (2-methoxyphenyl) -1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione", "ANTAGONIST", "alpha (1D) -adrenoceptor"], ["prazosin", "ANTAGONIST", "alpha (1) -adrenoceptor"]]