You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["HealthCareActivity", "InjuryOrPoisoning", "BodySubstance", "IntellectualProduct", "AnatomicalStructure", "SpatialConcept", "Chemical", "Bacterium", "MedicalDevice", "Organization", "BiomedicalOccupationOrDiscipline", "Finding", "BiologicFunction", "Virus", "ResearchActivity", "ClinicalAttribute", "PopulationGroup", "Eukaryote", "BodySystem", "Food", "ProfessionalOrOccupationalGroup"].

Please return the output as a JSON object of the format: {"Virus": ["HIV", ...], "Bacterium": ["MRSA", ...], "AnatomicalStructure": ["Lung", ...], "BodySystem": ["CNS", ...], "BodySubstance": ["Serum", ...], "Finding": ["Headache", ...], "InjuryOrPoisoning": ["Fracture", ...], "BiologicFunction": ["Death", ...], "HealthCareActivity": ["Biopsy", ...], "ResearchActivity": ["Clinical trial", ...], "MedicalDevice": ["Lenses", ...], "SpatialConcept": ["Camps", ...], "BiomedicalOccupationOrDiscipline": ["Forensic medicine", ...], "Organization": ["WHO", ...], "ProfessionalOrOccupationalGroup": ["Provider", ...], "PopulationGroup": ["Swimmers", ...], "Chemical": ["Gold", ...], "Food": ["Rice", ...], "IntellectualProduct": ["RPAM", ...], "ClinicalAttribute": ["Biomarker", ...], "Eukaryote": ["Dogs", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Doxifluridine - conjugated 2-5A analog shows strong RNase L activation ability and tumor suppressive effect RNase L is activated by 2',5'-oligoadenylates (2-5A) at subnanomolar levels to cleave single-stranded RNA. We previously reported the hypothesis that the introduction of an 8-methyladenosine residue at the 2'- terminus of the 2-5A tetramer shifts the 2-5A binding site of RNase L. In this study, we synthesized various 5'- modified 2-5A analog s with 8-methyladenosine at the 2'- terminus. The doxifluridine - conjugated 8-methyladenosine - substituted 2-5A analog was significantly more effective as an activator of RNase L than the parent 5'- monophophorylated 2-5A tetramer and showed a tumor suppressive effect against human cervical cancer cells.
{"AnatomicalStructure": ["cells"], "Bacterium": [], "BiologicFunction": ["tumor suppressive", "cervical cancer", "monophophorylated"], "BiomedicalOccupationOrDiscipline": [], "BodySubstance": [], "BodySystem": [], "Chemical": ["binding site", "doxifluridine", "RNase L", "Doxifluridine", "analog", "8-methyladenosine", "2-5A tetramer", "2-5A", "single-stranded RNA", "2\u0027,5\u0027-oligoadenylates"], "ClinicalAttribute": [], "Eukaryote": ["human"], "Finding": [], "Food": [], "HealthCareActivity": [], "InjuryOrPoisoning": [], "IntellectualProduct": ["reported"], "MedicalDevice": [], "Organization": [], "PopulationGroup": [], "ProfessionalOrOccupationalGroup": [], "ResearchActivity": ["study"], "SpatialConcept": ["cleave", "terminus", "conjugated"], "Virus": []}