You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["RNA", "CellLine", "Protein", "DNA", "CellType"].

Please return the output as a JSON object of the format: {"DNA" : ["TAL1", ...], "RNA": ["mRNAs", ...], "CellLine": ["T cells", ...], "CellType": ["monocytes", ...], "Protein": ["IL-2", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Specific depletion of the B-cell population induced by aberrant expression of human interferon regulatory factor 1 gene in transgenic mice. Interferons (IFNs) are well known both as antiviral proteins and as potent regulators of cell growth and differentiation. In fact, IFNs inhibit growth of various normal and transformed cell types. Previously, a nuclear factor, IRF-1 (interferon regulatory factor 1), which binds to type I IFN and some IFN-inducible gene promoters, was identified and cloned. Since the IRF-1 gene is both virus and IFN inducible, an intriguing issue is raised as to whether the IRF-1 gene is functioning in IFN-mediated regulation of cell growth and differentiation. In this study, we generated transgenic mice carrying the human IRF-1 gene linked to the human immunoglobulin heavy-chain enhancer. In the transgenic mice, all the lymphoid tissues examined showed a dramatic reduction in the number of B lymphocytes (B cells). Preparation and analysis of bone marrow cells from the chimeric mice indicated that the bone marrow is the effective site for specific depletion of the B-cell population. In fact, transgenic bone marrow cells cocultured with a bone marrow-derived stromal cell line revealed an altered B-cell maturation pattern.
{"CellLine": ["bone marrow - derived stromal cell line", "transgenic bone marrow cells", "B - cell population"], "CellType": ["B lymphocytes", "normal", "transformed cell types", "B - cell population", "B cells", "bone marrow cells", "B - cell"], "DNA": ["human IRF - 1 gene", "IFN - inducible gene promoters", "human interferon regulatory factor 1 gene", "IRF - 1 gene", "human immunoglobulin heavy - chain enhancer", "the IRF - 1 gene", "the human IRF - 1 gene", "type I IFN"], "Protein": ["Interferons", "IRF - 1", "IFN", "IRF - 1 (interferon regulatory factor 1)", "human immunoglobulin heavy - chain", "interferon regulatory factor 1", "human interferon regulatory factor 1", "IFNs", "nuclear factor", "antiviral proteins"], "RNA": []}