You are provided with the abstract of a scientific paper and the abstracts of the papers it references. Your task is to write a Related Work section for the main paper. This section should concisely summarize and integrate the key points from the cited abstracts, reflecting how they relate to the main paper's contributions and context. In your summary, use numerical citation markers like [1], [2], etc., to refer to the corresponding papers.

Main Abstract:
The Moran process is a randomised algorithm that models the spread of genetic mutations through graphs. If the graph is connected, the process eventually reaches "fixation", where every vertex is a mutant, or "extinction", where no vertex is a mutant. Our main result is an almost-tight bound on the expected running time of the algorithm. For all epsilon > 0, we show that the expected running time on an n-vertex graph is o(n^(3+epsilon)). In fact, we show that it is at most n^3 * exp(O((log log n)^3)) and that there is a family of graphs where it is Omega(n^3). In the course of proving our main result, we also establish a phase transition in the probability of fixation, depending on the fitness parameter r of the mutation. We show that no similar phase transition occurs for digraphs, where it is already known that the expected running time can also be exponential. Finally, we give an improved FPRAS for approximating the probability of fixation. Its running time is independent of the size of the graph when the maximum degree is bounded.

Cited Abstract(s):
[1]: We consider the classic Moran process modeling the spread of genetic mutations, as extended to structured populations by (Nature, 2005). In this process, individuals are the vertices of a connected graph G. Initially, there is a single mutant vertex, chosen uniformly at random. In each step, a random vertex is selected for reproduction with a probability proportional to its fitness: mutants have fitness r > 1, while non-mutants have fitness 1. The vertex chosen to reproduce places a copy of itself to a uniformly random neighbor in G, replacing the individual that was there. The process ends when the mutation either reaches fixation (i.e., all vertices are mutants), or gets extinct. The principal quantity of interest is the probability with which each of the two outcomes occurs. A problem that has received significant attention recently concerns the existence of families of graphs, called strong amplifiers of selection, for which the fixation probability tends to 1 as the order n of the graph increases, and the existence of strong suppressors of selection, for which this probability tends to 0. For the case of directed graphs, it is known that both strong amplifiers and suppressors exist. For the case of undirected graphs, however, the problem has remained open, and the general belief has been that neither strong amplifiers nor suppressors exist. In this paper we disprove this belief, by providing the first examples of such graphs. The strong amplifier we present has fixation probability 1 − ˜ O(n^ −1 3), and the strong suppressor has fixation probability ˜O(n^−1 4). Both graph constructions are surprisingly simple. We also prove a general upper bound of 1 − ˜Ω(n^−1 3) on the fixation probability of any undirected graph. Hence, our strong amplifier is existentially optimal.

[2]: A fuel pin hold-down and spacing apparatus for use in nuclear reactors is disclosed. Fuel pins forming a hexagonal array are spaced apart from each other and held-down at their lower end, securely attached at two places along their length to one of a plurality of vertically disposed parallel plates arranged in horizontally spaced rows. These plates are in turn spaced apart from each other and held together by a combination of spacing and fastening means. The arrangement of this invention provides a strong vibration free hold-down mechanism while avoiding a large pressure drop to the flow of coolant fluid. This apparatus is particularly useful in connection with liquid cooled reactors such as liquid met al cooled fast breeder reactors.

[3]: The Moran process, as studied by Lieberman, Hauert, and Nowak, is a randomised algorithm modelling the spread of genetic mutations in populations. The algorithm runs on an underlying graph where individuals correspond to vertices. Initially, one vertex (chosen uniformly at random) possesses a mutation, with fitness r > 1. All other individuals have fitness 1. During each step of the algorithm, an individual is chosen with probability proportional to its fitness, and its state (mutant or nonmutant) is passed on to an out-neighbour which is chosen uniformly at random. If the underlying graph is strongly connected, then the algorithm will eventually reach fixation, in which all individuals are mutants, or extinction, in which no individuals are mutants. An infinite family of directed graphs is said to be strongly amplifying if, for every r > 1, the extinction probability tends to 0 as the number of vertices increases. A formal definition is provided in the article. Strong amplification is a rather surprising property—it means that in such graphs, the fixation probability of a uniformly placed initial mutant tends to 1 even though the initial mutant only has a fixed selective advantage of r > 1 (independently of n). The name “strongly amplifying” comes from the fact that this selective advantage is “amplified.” Strong amplifiers have received quite a bit of attention, and proposed two potentially strongly amplifying families—superstars and metafunnels. Heuristic arguments have been published, arguing that there are infinite families of superstars that are strongly amplifying. The same has been claimed for metafunnels. In this article, we give the first rigorous proof that there is an infinite family of directed graphs that is strongly amplifying. We call the graphs in the family “megastars.” When the algorithm is run on an n-vertex graph in this family, starting with a uniformly chosen mutant, the extinction probability is roughly n − 1 2 (up to logarithmic factors). We prove that all infinite families of superstars and metafunnels have larger extinction probabilities (as a function of n). Finally, we prove that our analysis of megastars is fairly tight—there is no infinite family of megastars such that the Moran algorithm gives a smaller extinction probability (up to logarithmic factors). Also, we provide a counterexample which clarifies the literature concerning the isothermal theorem of
In , we alluded to the fact that the problem of finding the strongest possible amplifier had essentially been solved. Any directed graph has extinction probability @math [2] , which is tight up to a polylogarithmic factor [3] , and any undirected graph has extinction probability @math , which is tight up to a constant factor [2] . In fact, the results of [2] generalise to sparse graphs; any @math -edge undirected graph has extinction probability @math , which is also tight up to a constant factor. (See also Giakkoupis [1] for a lower bound of @math in the dense undirected setting, which is proved to be tight to within a factor of @math .)