You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["Outcome", "Participant", "Intervention"].

Please return the output as a JSON object of the format: {"Participant" : ["patients with COPD", ...], "Intervention" : ["Atenolol", ...], "Outcome" : ["blood pressure", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

MRI signal hyperintensities and failure to remit following antidepressant treatment . BACKGROUND MRI signal hyperintensities predict poor remission to antidepressant treatment . Previous studies using volumetrics in outpatient samples have relied on total lesion volume . The purpose of this study was to test whether remission from geriatric depression depends on lesion volume by region of interest ( ROI ) . METHOD Thirty-eight patients received baseline MRIs as part of a larger 12-week , randomized clinical trial comparing sertraline and nortriptyline in the treatment of late-life depression . MRIcro was used to quantify MRI-hyperintensity volume into total hyperintensity , deep white matter hyperintensity ( DWMH ) , and periventricular hyperintensity ( PVH ) volumes . High versus low total , DWMH , and PVH volumes were defined based on the highest quartile of their respective distributions . Remission from depression was defined as a 24-item Hamilton Rating Scale for Depression score ≤ 7 for two consecutive weeks . RESULTS Patients classified as having high DWMH were 7.14 times more likely not to remit following antidepressant treatment compared to patients classified as having low DWMH ( p=0.02 ) . Similar odds ratios were obtained for PVH ( OR=4.17 , p=0.16 ) and total volumes ( OR=5.00 , p=0.05 ) . Importantly , adjusting for age did not change the magnitude of these effects . LIMITATIONS A small and predominantly White sample . CONCLUSIONS This is the first study to test whether remission from geriatric depression depends on lesion volume by ROI in an outpatient sample . The pattern of remission rates and odds ratios was similar when patients were classified as having high DWMH , PVH or total volume suggesting that lesion location may not be critical .
{"Intervention": ["antidepressant treatment", "sertraline", "baseline MRIs", "nortriptyline"], "Outcome": ["and", "remission", ".", "failure to remit", "DWMH", "Hamilton Rating Scale for Depression score", "lesion volume by region of interest ( ROI )", "Remission from depression", "MRI signal hyperintensities", "total lesion volume", "PVH volumes", ", and"], "Participant": ["late-life depression", "Thirty-eight", "geriatric depression"]}