You will be shown inclusion or exclusion criteria for a clinical trial. Given these criteria, your task is to extract all unique entities of the following types: ["Observation", "Condition", "Procedure", "Drug", "Temporal", "Multiplier", "Qualifier", "Negation", "ReferencePoint", "Scope", "Value", "Mood", "Device", "Visit", "Measurement", "Person"].

Please return the output as a JSON object of the format: {"Condition" : ["breast cancer", ...], "Device" : ["ports", ...], "Drug" : ["Atenolol", ...], "Measurement" : ["blood pressure", ...], "Mood" : ["suspected", ...], "Multiplier" : ["more than two", ...], "Negation" : ["no", ...], "Observation" : ["history", ...], "Person" : ["male", ...], "Procedure" : ["surgery", ...], "Qualifier" : ["severe", ...], "ReferencePoint" : ["enrollment", ...], "Scope" : ["infection", ...], "Temporal" : ["one day", ...], "Value" : ["50%", ...], "Visit" : ["ICU", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

1. Patients over the age of 85 years except at the discretion of the Investigator and with agreement of the Sponsor. 
2. Diagnosis of acute promyelocytic leukemia 
3. Diagnosis of chronic myelogenous leukemia (CML) in blast crisis 
4. AML in relapse or refractory after 3 or more previous lines of chemotherapy (and/or HSCT) treatment 
5. AML or antecedent MDS secondary to prior chemotherapy 
6. Persistent clinically significant non-hematological toxicity that is Grade >1 by NCI CTCAE v4 from prior chemotherapy 
7. Patients who have had HSCT and are within 100 days of transplant and/or are still taking immunosuppressive drugs and/or have clinically significant graft-versus-host disease requiring treatment and/or have >Grade 1 persistent non hematological toxicity related to the transplant 
8. Clinically active central nervous system (CNS) leukemia. Patients with CNS leukemia, which is controlled, but who are still receiving IT therapy at study entry may be considered eligible and continue receive IT therapy at the discretion of the Investigator and with agreement of the Sponsor. 
9. Patients who have previously received AC220 
10. Disseminated intravascular coagulation (DIC) (diagnosis by laboratory or clinical assessment) 
11. Major surgery within 4 weeks prior to enrollment in the study 
12. Radiation therapy within 4 weeks prior to, or concurrent with study 
13. Use of concomitant drugs that prolong QT/QTc interval and/or are CYP3A4 inhibitors are prohibited with the exception of antibiotics, antifungals, and other antimicrobials that are used as standard of care to prevent or treat infections and other such drugs that are considered absolutely essential for the care of the patient. 
14. Uncontrolled or significant cardiovascular disease 
15. Women who are pregnant, lactating, or unwilling to use contraception if of childbearing potential 
16. Men who are unwilling to use contraception if their partners are of childbearing potential 
17. Active, uncontrolled infection 
18. Human immunodeficiency virus positivity 
19. Active hepatitis B or C or other active liver disease 
20. History of cancer, except Stage 1 cervix or nonmelanotic skin cancer, with the possible exception of patients in complete remission
{"Condition": ["central nervous system (CNS) leukemia", "hepatitis B", "prolong QT/QTc interval", "contraception", "lactating", "graft-versus-host disease", "infection", "Human immunodeficiency virus", "cancer", "AML", "childbearing potential", "MDS", "toxicity", "Disseminated intravascular coagulation (DIC)", "hepatitis C", "skin cancer", "blast crisis", "HSCT", "cardiovascular disease", "acute promyelocytic leukemia", "liver disease", "chronic myelogenous leukemia (CML)", "pregnant", "chemotherapy"], "Device": [], "Drug": ["antibiotics", "AC220", "CYP3A4 inhibitors", "antifungals", "drugs that prolong QT/QTc interval", "immunosuppressive drugs", "antimicrobials", "contraception"], "Measurement": ["Human immunodeficiency virus", "NCI CTCAE v4"], "Mood": ["unwilling", "requiring"], "Multiplier": ["3 or more", "persistent"], "Negation": ["with the exception of", "except"], "Observation": ["History", "their partners are of childbearing potential"], "Person": ["Men", "age"], "Procedure": ["Radiation therapy", "transplant", "Major surgery", "chemotherapy", "lines of chemotherapy", "treatment"], "Qualifier": ["\u003eGrade 1", "Uncontrolled", "persistent", "Grade \u003e1 by NCI CTCAE v4", "significant", "clinically significant", "non hematological", "Stage 1 cervix", "refractory", "in relapse", "that prolong QT/QTc interval", "non-hematological", "nonmelanotic", "uncontrolled"], "ReferencePoint": ["transplant", "enrollment", "study"], "Scope": ["hepatitis B or C", "AML or antecedent MDS", "antibiotics, antifungals, and other antimicrobials", "Uncontrolled or significant", "drugs that prolong QT/QTc interval and/or are CYP3A4 inhibitors", "within 4 weeks prior to, or concurrent with study", "in relapse or refractory"], "Temporal": ["still", "have had", "prior", "Active", "within 4 weeks prior to study", "antecedent", "after 3 or more previous lines of chemotherapy", "within 4 weeks prior to enrollment", "active", "concurrent with study", "within 100 days of transplant", "previous"], "Value": ["Grade \u003e1", "over the age of 85 years", "positivity"], "Visit": []}