Given an abstract from a research paper, your task is to identify and label relationships between chemical compounds and genes mentioned in the abstract.

The relationship type must be one of ['DOWNREGULATOR', 'SUBSTRATE', 'INDIRECT-REGULATOR', 'PART-OF', 'MODULATOR-ACTIVATOR', 'REGULATOR', 'INHIBITOR', 'COFACTOR', 'UPREGULATOR', 'ACTIVATOR', 'ANTAGONIST', 'NOT', 'INDIRECT-DOWNREGULATOR', 'SUBSTRATE_PRODUCT-OF', 'INDIRECT-UPREGULATOR', 'AGONIST', 'PRODUCT-OF', 'MODULATOR', 'DIRECT-REGULATOR', 'UNDEFINED', 'AGONIST-INHIBITOR', 'AGONIST-ACTIVATOR', 'MODULATOR-INHIBITOR'].

Please format your output as a JSON array. Each entry in the array should express a single relation, formatted as ["<Entity_A>", "<RELATION_A_B>", "<Entity_B>"]. If no relations can be found, please output an empty JSON array [].

Abstract:

Pre-steady-state currents in neutral amino acid transporters induced by photolysis of a new caged alanine derivative. Na+-Dependent transmembrane transport of small neutral amino acids, such as glutamine and alanine, is mediated, among others, by the neutral amino acid transporters of the solute carrier 1 [ SLC1, alanine serine cysteine transporter 1 (ASCT1), and ASCT2 ] and SLC38 families [ sodium-coupled neutral amino acid transporter 1 (SNAT1), SNAT2, and SNAT4 ]. Many mechanistic aspects of amino acid transport by these systems are not well-understood. Here, we describe a new photolabile alanine derivative based on protection of alanine with the 4-methoxy-7-nitroindolinyl (MNI) caging group, which we use for pre-steady-state kinetic analysis of alanine transport by ASCT2, SNAT1, and SNAT2. MNI-alanine has favorable photochemical properties and is stable in aqueous solution. It is also inert with respect to the transport systems studied. Photolytic release of free alanine results in the generation of significant transient current components in HEK293 cells expressing the ASCT2, SNAT1, and SNAT2 proteins. In ASCT2, these currents show biphasic decay with time constants, tau, in the 1-30 ms time range. They are fully inhibited in the absence of extracellular Na+, demonstrating that Na+ binding to the transporter is necessary for induction of the alanine-mediated current. For SNAT1, these transient currents differ in their time course (tau = 1.6 ms) from previously described pre-steady-state currents generated by applying steps in the membrane potential (tau approximately 4-5 ms), indicating that they are associated with a fast, previously undetected, electrogenic partial reaction in the SNAT1 transport cycle. The implications of these results for the mechanisms of transmembrane transport of alanine are discussed. The new caged alanine derivative will provide a useful tool for future, more detailed studies of neutral amino acid transport.
[["alanine", "SUBSTRATE", "ASCT2"], ["alanine", "SUBSTRATE", "sodium-coupled neutral amino acid transporter 1"], ["alanine", "SUBSTRATE", "solute carrier 1"], ["amino acids", "SUBSTRATE", "SLC38"], ["alanine", "SUBSTRATE", "SNAT4"], ["glutamine", "SUBSTRATE", "SLC38"], ["glutamine", "SUBSTRATE", "alanine serine cysteine transporter 1"], ["amino acids", "SUBSTRATE", "SNAT1"], ["amino acids", "SUBSTRATE", "alanine serine cysteine transporter 1"], ["4-methoxy-7-nitroindolinyl", "SUBSTRATE", "SNAT1"], ["alanine", "REGULATOR", "ASCT2"], ["amino acids", "SUBSTRATE", "neutral amino acid transporters"], ["glutamine", "SUBSTRATE", "neutral amino acid transporters"], ["alanine", "SUBSTRATE", "SNAT1"], ["amino acids", "SUBSTRATE", "SNAT4"], ["4-methoxy-7-nitroindolinyl", "SUBSTRATE", "ASCT2"], ["alanine", "SUBSTRATE", "neutral amino acid transporters"], ["glutamine", "SUBSTRATE", "ASCT1"], ["glutamine", "SUBSTRATE", "SLC1"], ["amino acids", "SUBSTRATE", "solute carrier 1"], ["glutamine", "SUBSTRATE", "sodium-coupled neutral amino acid transporter 1"], ["amino acids", "SUBSTRATE", "sodium-coupled neutral amino acid transporter 1"], ["glutamine", "SUBSTRATE", "SNAT1"], ["glutamine", "SUBSTRATE", "SNAT4"], ["glutamine", "SUBSTRATE", "SNAT2"], ["alanine", "SUBSTRATE", "alanine serine cysteine transporter 1"], ["alanine", "SUBSTRATE", "SLC1"], ["alanine", "SUBSTRATE", "ASCT1"], ["glutamine", "SUBSTRATE", "solute carrier 1"], ["4-methoxy-7-nitroindolinyl", "SUBSTRATE", "SNAT2"], ["glutamine", "SUBSTRATE", "ASCT2"], ["MNI", "SUBSTRATE", "SNAT1"], ["alanine", "REGULATOR", "neutral amino acid transporters"], ["MNI", "SUBSTRATE", "SNAT2"], ["alanine", "REGULATOR", "SNAT1"], ["amino acids", "SUBSTRATE", "ASCT1"], ["amino acids", "SUBSTRATE", "SNAT2"], ["amino acids", "SUBSTRATE", "SLC1"], ["amino acids", "SUBSTRATE", "ASCT2"], ["alanine", "REGULATOR", "SNAT2"], ["alanine", "SUBSTRATE", "SNAT2"], ["MNI", "SUBSTRATE", "ASCT2"]]