You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["Outcome", "Participant", "Intervention"].

Please return the output as a JSON object of the format: {"Participant" : ["patients with COPD", ...], "Intervention" : ["Atenolol", ...], "Outcome" : ["blood pressure", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

High-dose pyridoxine and magnesium administration in children with autistic disorder : an absence of salutary effects in a double-blind , placebo-controlled study . Several reports have described salutary effects such as decreased physical aggression and improved social responsiveness being associated with the administration of high doses of pyridoxine and magnesium ( HDPM ) in open-labeled and controlled studies of patients with autism . Despite this fact , this intervention remains controversial . A 10-week double-blind , placebo-controlled trial was undertaken to examine both the efficacy and safety of HDPM in autism . Twelve patients were enrolled , and 10 patients ( mean age 6 years 3 months ) were able to complete the study . HDPM at an average dose of 638.9 mg of pyridoxine and 216.3 mg of magnesium oxide was ineffective in ameliorating autistic behaviors as assessed by the Children 's Psychiatric Rating Scale ( CPRS ) , the Clinical Global Impression Scale , and the NIMH Global Obsessive Compulsive Scale . Furthermore , no clinically significant side effects were noted during HDPM administration . A trend for a transient change on the CPRS was found that was possibly due to a placebo response . This study raises doubts about the clinical effectiveness of HDPM in autistic disorder .
{"Intervention": ["magnesium oxide", "High-dose pyridoxine and magnesium administration", "pyridoxine", "HDPM", "pyridoxine and magnesium ( HDPM )"], "Outcome": ["NIMH Global Obsessive Compulsive Scale", "the Clinical Global Impression Scale", "Children \u0027s Psychiatric Rating Scale ( CPRS )", "ameliorating autistic behaviors"], "Participant": ["Twelve", "10", "autistic disorder", "autism", "children", "6 years 3 months"]}