You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["Disease"].

Please return the output as a JSON object of the format: {"Disease" : ["COVID-19", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

The DCC protein and prognosis in colorectal cancer. BACKGROUND  Allelic loss of chromosome 18q predicts a poor outcome in patients with stage II colorectal cancer. Although the specific gene inactivated by this allelic loss has not been elucidated, the DCC (deleted in colorectal cancer) gene is a candidate. We investigated whether the expression of the DCC protein in tumor cells is a prognostic marker in colorectal carcinoma. METHODS  The expression of DCC was evaluated immunohistochemically in 132 paraffin-embedded samples from patients with curatively resected stage II and III colorectal carcinomas. The Cox proportional-hazards model was used to adjust for covariates including age, sex, tumor site, degree of tumor differentiation, and use of adjuvant therapy. RESULTS  The expression of DCC was a strong positive predictive factor for survival in both stage II and stage III colorectal carcinomas. In patients with stage II disease whose tumors expressed DCC, the five-year survival rate was 94. 3 percent, whereas in patients with DCC-negative tumors, the survival rate was 61. 6 percent (P < 0. 001). In patients with stage III disease, the respective survival rates were 59. 3 percent and 33. 2 percent (P = 0. 03). CONCLUSIONS  DCC is a prognostic marker in patients with stage II or stage III colorectal cancer. In stage II colorectal carcinomas, the absence of DCC identifies a subgroup of patients with lesions that behave like stage III cancers. These findings may thus have therapeutic implications in this group of patients
{"Disease": ["stage II or stage III colorectal cancer", "tumors", "stage II and III colorectal carcinomas", "tumor", "colorectal carcinoma", "stage II colorectal carcinomas", "stage III disease", "stage II colorectal cancer", "stage II and stage III colorectal carcinomas", "colorectal cancer", "stage III cancers", "DCC-negative tumors"]}