You are presented with a paragraph from a COVID-19 literature. Classify the topics of this piece of text by choosing from the following categories:

- Epidemic Forecasting: The content relates to predictions about the spread of COVID-19.
- Treatment: The paragraph discusses therapeutic methods or medication for COVID-19.
- Prevention: The content covers measures to prevent the spread of COVID-19.
- Mechanism: The paragraph explains the biological mechanisms of the virus.
- Case Report: The content is a report of a COVID-19 case.
- Transmission: The paragraph discusses how COVID-19 is transmitted.
- Diagnosis: The content is about diagnosing COVID-19 in individuals.

Your classification should be provided as an element within a JSON array. The array should be formatted with topics enclosed in double quotes and separated by commas, following the JSON format, for example: ["Topic1", "Topic2", ...]. Include all applicable topics within the array. Your output should be a valid JSON array, and no additional text should be included in your response.

Article:

Introduction: The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged as a novel viral agent that quickly spread worldwide. SARS-CoV-2 is responsible for the human coronavirus disease 2019 (COVID-19) which has claimed hundreds of thousands of lives and had an immeasurable toll on the economy. Currently, most clinical cases are identified by qualitative molecular testing. However, the need for quantitative assessment is gaining traction.Areas covered: In this review, the current state and future perspective of SARS-CoV-2 viral load quantification is presented.Expert opinion: Viral load quantification is a critical measure that informs clinicians of treatment response, actionable viral load levels, and guidance on patient management. Additionally, for pathogens with epidemiological consequences, viral load can provide information to guide infection control measures and policies. While qualitative detection is sufficient to identify cases and initiate containment and mitigation measures in the vast majority of COVID-19 cases, in certain situations, SARS-CoV-2 quantification is needed to assess viral load trending. However, there are obstacles to quantification, including variability in respiratory specimen collection and the lack of commutable reference material. At the same time, the need for quantification for clinical and epidemiological management is growing, especially concerning individuals with prolonged RNA shedding.
["Diagnosis"]