You have to answer a biomedical question in binary format, i.e. only yes and no are the only acceptable answer formats. A list of paragraphs is provided as context to help you answer the question.

Question: Is CREB a key memory protein?

Context: Human cyclic AMP response element binding protein (CREB) transcription factor which plays a crucial role in memory
The activated CREB is implicated in the regulation of development, protection, learning, memory and plasticity in the nerve system.
A mouse genetic study showed that cAMP-responsive element-binding protein (CREB)-mediated transcription is required for the formation of social recognition memory.
Transcription factor cAMP response element-binding protein (CREB) plays a critical role in memory formation.
It is well known that molecules like cAMP response element binding (CREB) and binding protein (CBP) play a crucial role in memory consolidation.
CREB SUMOylation by the E3 ligase PIAS1 enhances spatial memory.
Therefore, CREB phosphorylation may be responsible for signal transduction during the early phase of long-term memory formation, whereas CREB SUMOylation sustains long-term memory
yes