You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["HealthCareActivity", "InjuryOrPoisoning", "BodySubstance", "IntellectualProduct", "AnatomicalStructure", "SpatialConcept", "Chemical", "Bacterium", "MedicalDevice", "Organization", "BiomedicalOccupationOrDiscipline", "Finding", "BiologicFunction", "Virus", "ResearchActivity", "ClinicalAttribute", "PopulationGroup", "Eukaryote", "BodySystem", "Food", "ProfessionalOrOccupationalGroup"].

Please return the output as a JSON object of the format: {"Virus": ["HIV", ...], "Bacterium": ["MRSA", ...], "AnatomicalStructure": ["Lung", ...], "BodySystem": ["CNS", ...], "BodySubstance": ["Serum", ...], "Finding": ["Headache", ...], "InjuryOrPoisoning": ["Fracture", ...], "BiologicFunction": ["Death", ...], "HealthCareActivity": ["Biopsy", ...], "ResearchActivity": ["Clinical trial", ...], "MedicalDevice": ["Lenses", ...], "SpatialConcept": ["Camps", ...], "BiomedicalOccupationOrDiscipline": ["Forensic medicine", ...], "Organization": ["WHO", ...], "ProfessionalOrOccupationalGroup": ["Provider", ...], "PopulationGroup": ["Swimmers", ...], "Chemical": ["Gold", ...], "Food": ["Rice", ...], "IntellectualProduct": ["RPAM", ...], "ClinicalAttribute": ["Biomarker", ...], "Eukaryote": ["Dogs", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Panitumumab -Associated Encephalopathy after Accidental Intra-arterial Application through Dislocated Central Venous Access Device Acute central nervous system (CNS) toxicity and immune -related side effects are increasingly recognized with the use of monoclonal antibodies for cancer therapy. Here, we report a patient who developed of acute-onset encephalopathy and coma, which began shortly after administration of panitumumab for the treatment of metastatic colorectal cancer. Echocardiography revealed that the drug had been infused into the left cardiac ventricle via a dislocated central venous line. Diffusion-weighted magnetic resonance imaging disclosed multiple cortical hyperintensities, which were preferentially located in the frontal lobes. While the neurological condition improved within a few days, the patient died 4 weeks later. It seems likely that the administration of the antibody via the intra-arterial route contributed to the development of this condition. Toxic encephalopathy may be a hitherto unrecognized complication of panitumumab treatment and should be taken into consideration in patients developing CNS symptoms undergoing this therapy.
{"AnatomicalStructure": ["left cardiac ventricle", "frontal lobes"], "Bacterium": [], "BiologicFunction": ["metastatic colorectal cancer", "Encephalopathy", "died", "complication", "neurological condition", "coma", "condition", "side effects"], "BiomedicalOccupationOrDiscipline": [], "BodySubstance": [], "BodySystem": ["central nervous system", "CNS"], "Chemical": ["monoclonal antibodies", "antibody", "Panitumumab", "drug", "panitumumab"], "ClinicalAttribute": [], "Eukaryote": [], "Finding": ["symptoms", "cortical hyperintensities", "acute-onset encephalopathy"], "Food": [], "HealthCareActivity": ["cancer therapy", "Application", "Diffusion-weighted magnetic resonance imaging", "treatment", "therapy", "Echocardiography"], "InjuryOrPoisoning": ["Toxic encephalopathy", "toxicity"], "IntellectualProduct": [], "MedicalDevice": ["Dislocated Central Venous Access Device", "dislocated central venous line"], "Organization": [], "PopulationGroup": [], "ProfessionalOrOccupationalGroup": [], "ResearchActivity": [], "SpatialConcept": [], "Virus": []}