You have to answer a biomedical question in binary format, i.e. only yes and no are the only acceptable answer formats. A list of paragraphs is provided as context to help you answer the question.

Question: Are super enhancers structurally insulated in chromatin loops?

Context: Dissecting super-enhancer hierarchy based on chromatin interactions
Genetic ablation of hub enhancers results in profound defects in gene activation and local chromatin landscape.
We also demonstrate that the Wap super-enhancer, which is built on STAT5 and other common transcription factors, retains its exquisite mammary specificity when placed into globally permissive chromatin, suggesting a limited role of chromatin in controlling cell specificity.
Although there is evidence that chromatin neighbourhoods, formed by the zinc-finger protein CTCF, can sequester enhancers and their target genes, there is limited in vivo evidence for CTCF demarcating super-enhancers and preventing cross talk between distinct regulatory elements.
CTCF sites are porous borders, allowing a super-enhancer to activate a secondary target.
Transcription factors and chromatin-remodeling complexes are key determinants of embryonic stem cell (ESC) identity.
no