You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["Outcome", "Participant", "Intervention"].

Please return the output as a JSON object of the format: {"Participant" : ["patients with COPD", ...], "Intervention" : ["Atenolol", ...], "Outcome" : ["blood pressure", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

The tolerability of lactated Ringer 's solution and BSS plus for ocular irrigation with and without the Morgan therapeutic lens . OBJECTIVE To evaluate two solutions , lactated Ringer 's ( LR ) and a balanced salt solution ( BSS Plus , Alcon Laboratories , Ft. Worth , TX ) , compared with normal saline solution ( NSS ) , for ocular irrigation in healthy adult volunteers with and without the Morgan therapeutic lens ( MTL ) . METHODS This was a prospective , double-blind , randomized study of healthy volunteers who were at least 18 years of age . Exclusion criteria included the use of analgesics within four hours of the study . A complete ophthalmologic examination was performed at baseline and at the completion of the study . Following randomization and prior to any intervention , baseline discomfort scores were obtained by means of a verbally administered , horizontal , 100-mm , unnumbered analog discomfort scale . Both eyes of each volunteer were irrigated simultaneously for 15 minutes , with additional discomfort scores being recorded every 5 minutes using the same 100-mm , unnumbered analog discomfort scale . A global evaluation to assess the method of irrigation and the solutions used for irrigation was completed by both the physician blinded to the treatment groups and the volunteers . The volunteers were continuously monitored for any adverse effects resulting from the irrigation solutions or MTL . RESULTS Sixty-three volunteers were recruited into the study , with 61 entered in the final analysis . Age and gender were balanced within each group . There was no significant difference in discomfort scores between the two groups ; however , all discomfort scores decreased over time ( p = 0.008 ) . A lens-solution interaction was identified , with LR being the most tolerated when administered with the MTL . A statistically higher ocular pH difference was seen between the pre- and postirrigation readings for the control eye in volunteers irrigated with MTL ( p = 0.046 ) . Analysis of the global evaluations for each group revealed no difference in the distributions of physician and volunteer scores . No adverse event was reported in either group . CONCLUSION There does not appear to be any difference in discomfort scores between the ocular irrigation fluids when used without the MTL . Overall , the use of the MTL appears well tolerated by healthy , adult volunteers . However , there does appear to be a significant lens-solution effect on volunteers ' discomfort scores , with LR having significantly lower discomfort scores when used for ocular irrigation with the MTL . The authors conclude that the use of the MTL for ocular irrigation is well tolerated and recommend using LR as the irrigation solution for maximal patient comfort .
{"Intervention": ["lactated Ringer \u0027s ( LR ) and a balanced salt solution", "eyes of each volunteer were irrigated simultaneously for 15 minutes", "saline solution ( NSS )", "lactated Ringer \u0027s solution", "BSS plus"], "Outcome": ["unnumbered analog discomfort scale .", "lens-solution effect", "adverse event", "adverse effects", "physician and volunteer scores .", "tolerated", "discomfort scores", "ocular pH difference"], "Participant": ["healthy adult volunteers with and without the Morgan therapeutic lens ( MTL ) ."]}