You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["HealthCareActivity", "InjuryOrPoisoning", "BodySubstance", "IntellectualProduct", "AnatomicalStructure", "SpatialConcept", "Chemical", "Bacterium", "MedicalDevice", "Organization", "BiomedicalOccupationOrDiscipline", "Finding", "BiologicFunction", "Virus", "ResearchActivity", "ClinicalAttribute", "PopulationGroup", "Eukaryote", "BodySystem", "Food", "ProfessionalOrOccupationalGroup"].

Please return the output as a JSON object of the format: {"Virus": ["HIV", ...], "Bacterium": ["MRSA", ...], "AnatomicalStructure": ["Lung", ...], "BodySystem": ["CNS", ...], "BodySubstance": ["Serum", ...], "Finding": ["Headache", ...], "InjuryOrPoisoning": ["Fracture", ...], "BiologicFunction": ["Death", ...], "HealthCareActivity": ["Biopsy", ...], "ResearchActivity": ["Clinical trial", ...], "MedicalDevice": ["Lenses", ...], "SpatialConcept": ["Camps", ...], "BiomedicalOccupationOrDiscipline": ["Forensic medicine", ...], "Organization": ["WHO", ...], "ProfessionalOrOccupationalGroup": ["Provider", ...], "PopulationGroup": ["Swimmers", ...], "Chemical": ["Gold", ...], "Food": ["Rice", ...], "IntellectualProduct": ["RPAM", ...], "ClinicalAttribute": ["Biomarker", ...], "Eukaryote": ["Dogs", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Inhibition of STEP61 ameliorates deficits in mouse and hiPSC -based schizophrenia models The brain - specific tyrosine phosphatase, STEP (STriatal-Enriched protein tyrosine Phosphatase) is an important regulator of synaptic function. STEP normally opposes synaptic strengthening by increasing N-methyl D-aspartate glutamate receptor (NMDAR) internalization through dephosphorylation of GluN2B and inactivation of the kinases extracellular signal-regulated kinase 1 / 2 and Fyn. Here we show that STEP61 is elevated in the cortex in the Nrg1(+/-) knockout mouse model of schizophrenia (SZ). Genetic reduction or pharmacological inhibition of STEP prevents the loss of NMDARs from synaptic membranes and reverses behavioral deficits in Nrg1(+/-) mice. STEP61 protein is also increased in cortical lysates from the central nervous system - specific ErbB2 / 4 mouse model of SZ, as well as in human induced pluripotent stem cell (hiPSC)-derived forebrain neurons and Ngn2 - induced excitatory neurons, from two independent SZ patient cohorts. In these selected SZ models, increased STEP61 protein levels likely reflect reduced ubiquitination and degradation. These convergent findings from mouse and hiPSC SZ models provide evidence for STEP61 dysfunction in SZ .Molecular Psychiatry advance online publication, 18 October 2016; doi:10.1038/mp.2016.163.
{"AnatomicalStructure": ["Ngn2", "excitatory neurons", "Nrg1(+/-)", "synaptic membranes", "cortex", "forebrain", "cortical", "human induced pluripotent stem cell", "hiPSC", "neurons", "brain"], "Bacterium": [], "BiologicFunction": ["dephosphorylation", "inactivation", "models", "synaptic function", "ubiquitination", "degradation", "mouse model", "SZ", "behavioral deficits", "knockout", "Inhibition", "schizophrenia"], "BiomedicalOccupationOrDiscipline": [], "BodySubstance": [], "BodySystem": ["central nervous system"], "Chemical": ["kinases", "STEP61 protein", "ErbB2", "NMDAR", "NMDARs", "tyrosine phosphatase", "N-methyl D-aspartate glutamate receptor", "2", "STEP", "4", "STEP61", "GluN2B", "Fyn", "extracellular signal-regulated kinase 1", "STriatal-Enriched protein tyrosine Phosphatase"], "ClinicalAttribute": [], "Eukaryote": ["mouse", "mice"], "Finding": ["findings"], "Food": [], "HealthCareActivity": ["reduction", "protein levels"], "InjuryOrPoisoning": [], "IntellectualProduct": [], "MedicalDevice": [], "Organization": [], "PopulationGroup": ["cohorts"], "ProfessionalOrOccupationalGroup": [], "ResearchActivity": [], "SpatialConcept": ["synaptic"], "Virus": []}