You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["Outcome", "Participant", "Intervention"].

Please return the output as a JSON object of the format: {"Participant" : ["patients with COPD", ...], "Intervention" : ["Atenolol", ...], "Outcome" : ["blood pressure", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

A prospective randomized trial of topical pimecrolimus for cetuximab-associated acnelike eruption . BACKGROUND Clinical trials addressing the acneiform rash associated with epidermal growth factor receptor inhibitors are lacking . OBJECTIVE We evaluated the ability of topical pimecrolimus to reduce the severity of cetuximab-related facial rash . METHODS In all , 24 patients with metastatic colorectal cancer with cetuximab facial rash received twice daily pimecrolimus application for 5 weeks to half of the face . At baseline , week 2 , and week 5 , a dermatologist performed facial lesion counts , patients reported perceived severity of rash-related symptoms , and standardized facial photographs were obtained for blinded evaluation of global rash severity . RESULTS Treatment sides had greater decrease in lesion counts than observation sides of face at weeks 2 ( P < .001 ) and 5 ( P = .02 ) . However , there were no significant differences in patients ' assessment of symptoms and in review of facial photographs for rash severity between treatment and observation sides . LIMITATIONS This study was not placebo controlled . CONCLUSIONS Pimecrolimus application did not translate into clinically meaningful benefit for patients with cetuximab-related facial rash .
{"Intervention": ["Pimecrolimus", "pimecrolimus"], "Outcome": ["lesion counts", "rash severity"], "Participant": ["24", "metastatic colorectal cancer with cetuximab facial rash", "cetuximab-related facial rash .", "cetuximab-associated acnelike eruption", "cetuximab-related facial rash"]}