Given an abstract from a research paper, your task is to identify and label relationships between chemical compounds and genes mentioned in the abstract.

The relationship type must be one of ['DOWNREGULATOR', 'SUBSTRATE', 'INDIRECT-REGULATOR', 'PART-OF', 'MODULATOR-ACTIVATOR', 'REGULATOR', 'INHIBITOR', 'COFACTOR', 'UPREGULATOR', 'ACTIVATOR', 'ANTAGONIST', 'NOT', 'INDIRECT-DOWNREGULATOR', 'SUBSTRATE_PRODUCT-OF', 'INDIRECT-UPREGULATOR', 'AGONIST', 'PRODUCT-OF', 'MODULATOR', 'DIRECT-REGULATOR', 'UNDEFINED', 'AGONIST-INHIBITOR', 'AGONIST-ACTIVATOR', 'MODULATOR-INHIBITOR'].

Please format your output as a JSON array. Each entry in the array should express a single relation, formatted as ["<Entity_A>", "<RELATION_A_B>", "<Entity_B>"]. If no relations can be found, please output an empty JSON array [].

Abstract:

Gemcitabine and Pemetrexed disodium in treating breast cancer. Pemetrexed disodium (Alimta, LY231514) is a novel, multitargeted antifolate that inhibits thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyl transferase. This agent is broadly active in a wide variety of solid tumors, including breast cancer. Pemetrexed disodium has also shown clinically relevant activity in combination with gemcitabine (Gemzar). This combination is being evaluated for the treatment of metastatic breast cancer.
[["Alimta", "INHIBITOR", "glycinamide ribonucleotide formyl transferase"], ["Pemetrexed disodium", "INHIBITOR", "dihydrofolate reductase"], ["Pemetrexed disodium", "INHIBITOR", "glycinamide ribonucleotide formyl transferase"], ["Alimta", "INHIBITOR", "thymidylate synthase"], ["LY231514", "INHIBITOR", "thymidylate synthase"], ["LY231514", "INHIBITOR", "glycinamide ribonucleotide formyl transferase"], ["Pemetrexed disodium", "INHIBITOR", "thymidylate synthase"], ["LY231514", "INHIBITOR", "dihydrofolate reductase"], ["Alimta", "INHIBITOR", "dihydrofolate reductase"]]