You will be presented with a collection of medical randomized controlled trial (RCT) reports addressing a shared clinical question -- for instance, the efficacy of a medical intervention on a disease or condition. Given the titles and abstracts of these reports, your task is to generate the conclusion of the systematic review article synthesizing the key findings. Your conclusion should be a few sentences long. In your response, include only the conclusion and no other text. The RCT reports are below.



Title 1:
Samarium-153-EDTMP bone uptake rate and its relation to therapeutic effect.
Abstract 1:
OBJECTIVE To evaluate the measurement of Samarium-153 ethylenediaminetetramethylene phosphonic acid ( (153)Sm-EDTMP ) bone uptake rate using whole-body scintigraphy and analyze the relationship between bone uptake rate and therapeutic effect . METHODS Sixty-six patients with painful bony metastases from prostate ( n = 15 ) , lung ( n = 20 ) , breast ( n= 18 ) , nasopharyngeal carcinoma ( NPC ) ( n=5 ) , colon ( n=2 ) , kidney ( n=2 ) and unknown cause ( n=4 ) carcinoma were examined with whole-body scintigraphy 10 min and 5 h post administration of (153)Sm-EDTMP .  Bone uptake rate was then calculated . ( 1 ) Complete response ( CR ) : disappearance of > 2 metastases , Karnofsky Performance Score ( KPS ) increase > 20 , moderate or complete remission of bone pain 7 d post injection of (153)Sm-EDTMP . ( 2 ) Partial response ( PR ) : disappearance of 1 - 2 metastases , KPS increase 10 - 20 , moderate remission of bone pain in 3 wk . ( 3 ) Non-response ( NR ) : no disappearance or shrinkage of metastases , KPS increase < 10 , no or slight remission of bone pain . RESULTS The range of bone uptake rate in 66 patients was 31 .9 % - 86.6 % ( mean = 56 . 0 % ) . The bone uptake rate in the CR group ( 17 cases , 25.7 % ) , PR group ( 24 cases , 36.4 % ) , and NR group ( 25 cases , 37.9 % ) was 52.4 % - 86.6 % ( mean = 68.7 % ) , 43.7 % - 70.4 % ( mean = 58.3 % ) , and 31.9%- 51 .5 % ( mean = 41 . 0 % ) respectively . Statistical analysis showed that there was a significant difference between the CR and PR groups ( t = 4.258 , P = 0.001 ) as well as between PR and NR groups ( t = 8.48,P = 0.001 ) . CONCLUSIONS Using a simple and reliable whole-body scintigraphic technique to calculate prospect ively the bone uptake rate , we have , for the first time in China , reported the relationship between bone uptake rate and therapeutic effect . This allows nuclear medicine physicians to calculate a safe and effective dose of (153)Sm-EDTMPin individual patients to palliate bone cancer pain without myelotoxicity
Although the data are limited , radioisotopes seem to reduce pain with a rapid onset of action and duration of response of 1 to 3 months .
The evidence that bisphosphonates or denosumab reduce or prevent pain in patients with NSCLC and bone metastases or that they have an influence on QoL is very weak .
Radioisotopes can be used to reduce diffuse pain , although there is no high-level evidence supporting such use