Given an abstract from a research paper, your task is to identify and label relationships between chemical compounds and genes mentioned in the abstract.

The relationship type must be one of ['DOWNREGULATOR', 'SUBSTRATE', 'INDIRECT-REGULATOR', 'PART-OF', 'MODULATOR-ACTIVATOR', 'REGULATOR', 'INHIBITOR', 'COFACTOR', 'UPREGULATOR', 'ACTIVATOR', 'ANTAGONIST', 'NOT', 'INDIRECT-DOWNREGULATOR', 'SUBSTRATE_PRODUCT-OF', 'INDIRECT-UPREGULATOR', 'AGONIST', 'PRODUCT-OF', 'MODULATOR', 'DIRECT-REGULATOR', 'UNDEFINED', 'AGONIST-INHIBITOR', 'AGONIST-ACTIVATOR', 'MODULATOR-INHIBITOR'].

Please format your output as a JSON array. Each entry in the array should express a single relation, formatted as ["<Entity_A>", "<RELATION_A_B>", "<Entity_B>"]. If no relations can be found, please output an empty JSON array [].

Abstract:

Optimization of 5-hydroxytryptamines as dual function inhibitors targeting phospholipase A2 and leukotriene A4 hydrolase. Dual function inhibitors targeting phospholipase A (2) (PLA (2)) and leukotriene A (4) hydrolase (LTA (4) H) may balance the arachidonic acid (AA) metabolic network and be used as new anti-inflammatory drugs. In previous study, we discovered multi-target drugs towards the AA metabolic network, among which a dual-target inhibitor (JMC08-4) for human nonpancreatic secretory phospholipase A (2) (hnps-PLA (2)) and human leukotriene A (4) hydrolase (LTA (4) H-h) was found. Based on the structure of compound JMC08-4, new dual-target inhibitors were designed assisted by molecular docking. In this report, a series of 5-hydroxytryptamine compounds were synthesized; and most of these title compounds showed more potent inhibitory activity than compound JMC08-4 in the in   vitro bioassay against these two enzymes. The best one inhibited hnps-PLA (2) and LTA (4) H-h with IC (50) values of 9.2   ±   0.5   μM and 2.4   ±   1.4   μM, respectively.
[["arachidonic acid", "PRODUCT-OF", "LTA (4) H"], ["5-hydroxytryptamines", "INHIBITOR", "phospholipase A2"], ["JMC08 - 4", "INHIBITOR", "human leukotriene A (4) hydrolase"], ["5-hydroxytryptamines", "INHIBITOR", "leukotriene A4 hydrolase"], ["arachidonic acid", "PRODUCT-OF", "PLA (2"], ["JMC08 - 4", "INHIBITOR", "LTA (4) H-h"], ["arachidonic acid", "PRODUCT-OF", "leukotriene A (4) hydrolase"], ["JMC08 - 4", "INHIBITOR", "human nonpancreatic secretory phospholipase A (2"], ["JMC08 - 4", "INHIBITOR", "hnps-PLA (2"], ["arachidonic acid", "PRODUCT-OF", "phospholipase A (2"]]