You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["HealthCareActivity", "InjuryOrPoisoning", "BodySubstance", "IntellectualProduct", "AnatomicalStructure", "SpatialConcept", "Chemical", "Bacterium", "MedicalDevice", "Organization", "BiomedicalOccupationOrDiscipline", "Finding", "BiologicFunction", "Virus", "ResearchActivity", "ClinicalAttribute", "PopulationGroup", "Eukaryote", "BodySystem", "Food", "ProfessionalOrOccupationalGroup"].

Please return the output as a JSON object of the format: {"Virus": ["HIV", ...], "Bacterium": ["MRSA", ...], "AnatomicalStructure": ["Lung", ...], "BodySystem": ["CNS", ...], "BodySubstance": ["Serum", ...], "Finding": ["Headache", ...], "InjuryOrPoisoning": ["Fracture", ...], "BiologicFunction": ["Death", ...], "HealthCareActivity": ["Biopsy", ...], "ResearchActivity": ["Clinical trial", ...], "MedicalDevice": ["Lenses", ...], "SpatialConcept": ["Camps", ...], "BiomedicalOccupationOrDiscipline": ["Forensic medicine", ...], "Organization": ["WHO", ...], "ProfessionalOrOccupationalGroup": ["Provider", ...], "PopulationGroup": ["Swimmers", ...], "Chemical": ["Gold", ...], "Food": ["Rice", ...], "IntellectualProduct": ["RPAM", ...], "ClinicalAttribute": ["Biomarker", ...], "Eukaryote": ["Dogs", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

The Daniel K. Inouye College of Pharmacy Scripts: Poha Berry (Physalis peruviana) with Potential Anti-inflammatory and Cancer Prevention Activities The Daniel K. Inouye College of Pharmacy, during a historic event in Spring 2016, graduated the first two students in the Pacific region to earn a PhD in pharmaceutical sciences at the University of Hawai'i at Hilo. The college offers PhD programs in these five disciplines: Cancer Biology, Medicinal Chemistry, Pharmaceutics, Pharmacognosy, and Pharmacology. One of the Pharmacognosy dissertations focused on plant-derived natural products with potential anti-inflammatory and cancer chemopreventive activities. Physalis peruviana (Pp) L. originated in tropical South America. It has become naturalized and is found readily on the Island of Hawai'i. The edible fruits are commonly known as cape gooseberry or poha in Hawai'i. In part of our study, three new withanolides, physaperuvin G (1), physaperuvins I-J (2-3), along with four known withanolides, namely, 4β-hydroxywithanolide E (4), withaperuvin C (5), and physalactone (6), coagulin (7) were isolated from the aerial parts of P. peruviana. In addition, two known compounds, phyperunolide F (8), and withanolide S (9), were isolated and identified from the poha berry fruits. The structures and absolute stereochemistry of new compounds from poha were elucidated by several spectroscopy methods: Nuclear Magnetic Resonance (NMR) spectroscopy, X-ray diffraction, and mass spectrometry analyses. All isolated poha compounds (aerial parts and fruits) were evaluated for their anti-inflammatory activity with lipopolysaccharide (LPS)-activated murine macrophage RAW 264.7 cells, and tumor necrosis factor alpha (TNF-α)-activated nuclear factor-kappa B (NF-κB) with transfected human embryonic kidney cells 293. Most of the isolated natural compounds showed activity with these assays. Additional studies were performed with models of colon cancer. Specifically, 4β-hydroxywithanolide E (4HWE) inhibited the growth of colon cancer monolayer and spheroid cultures. The compound induced cell cycle arrest at low concentrations and apoptosis at higher concentrations. These data suggest the ingestion of poha berries may have some effect on the prevalence of colon cancer. Additionally, poha isolates compounds were evaluated for their growth inhibitory effects with U251MG glioblastoma and MDA-MB-231 breast cancer cells that harbor aberrantly-active signal transducer and activation of transcription 3 (STAT3), compared to normal NIH-3T3 mouse fibroblasts. This work has led to the filing of three provisional patents with the University of Hawai'i Office of Technology Transfer and Economic Development.
{"AnatomicalStructure": ["human embryonic kidney cells 293", "spheroid", "NIH-3T3 mouse fibroblasts", "macrophage RAW 264.7 cells"], "Bacterium": [], "BiologicFunction": ["cell cycle arrest", "cancer", "apoptosis", "U251MG glioblastoma", "MDA-MB-231 breast cancer cells", "growth inhibitory effects", "colon cancer", "ingestion", "growth"], "BiomedicalOccupationOrDiscipline": ["pharmaceutical sciences", "Cancer Biology", "Pharmacognosy", "Pharmacology", "Medicinal Chemistry"], "BodySubstance": [], "BodySystem": [], "Chemical": ["withanolides", "phyperunolide F", "physaperuvin G", "physaperuvins I-J", "natural products", "isolates compounds", "withanolide S", "tumor necrosis factor alpha", "natural compounds", "4\u03b2-hydroxywithanolide E", "LPS", "nuclear factor-kappa B", "compound", "coagulin", "compounds", "signal transducer and activation of transcription 3 (STAT3)", "NF-\u03baB", "physalactone", "withaperuvin C", "4HWE", "TNF-\u03b1", "lipopolysaccharide"], "ClinicalAttribute": [], "Eukaryote": ["Physalis peruviana", "Pp", "plant-derived", "poha", "cape gooseberry", "murine", "P. peruviana", "aerial parts"], "Finding": [], "Food": ["Poha Berry", "fruits", "poha", "poha berries", "edible", "poha berry fruits"], "HealthCareActivity": ["X-ray diffraction", "mass spectrometry", "assays", "Nuclear Magnetic Resonance (NMR) spectroscopy", "Cancer Prevention", "monolayer", "cultures"], "InjuryOrPoisoning": [], "IntellectualProduct": ["The Daniel K. Inouye College of Pharmacy Scripts", "provisional patents", "models", "dissertations", "PhD"], "MedicalDevice": [], "Organization": ["college", "University of Hawai\u0027i", "University of Hawai\u0027i Office of Technology Transfer and Economic Development", "The Daniel K. Inouye College of Pharmacy"], "PopulationGroup": ["graduated", "students"], "ProfessionalOrOccupationalGroup": [], "ResearchActivity": ["analyses", "Pharmaceutics"], "SpatialConcept": ["Pacific region", "Hilo", "Island of Hawai\u0027i", "Hawai\u0027i", "structures", "South America", "absolute stereochemistry"], "Virus": []}