You will be shown inclusion or exclusion criteria for a clinical trial. Given these criteria, your task is to extract all unique entities of the following types: ["Observation", "Condition", "Procedure", "Drug", "Temporal", "Multiplier", "Qualifier", "Negation", "ReferencePoint", "Scope", "Value", "Mood", "Device", "Visit", "Measurement", "Person"].

Please return the output as a JSON object of the format: {"Condition" : ["breast cancer", ...], "Device" : ["ports", ...], "Drug" : ["Atenolol", ...], "Measurement" : ["blood pressure", ...], "Mood" : ["suspected", ...], "Multiplier" : ["more than two", ...], "Negation" : ["no", ...], "Observation" : ["history", ...], "Person" : ["male", ...], "Procedure" : ["surgery", ...], "Qualifier" : ["severe", ...], "ReferencePoint" : ["enrollment", ...], "Scope" : ["infection", ...], "Temporal" : ["one day", ...], "Value" : ["50%", ...], "Visit" : ["ICU", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

The patients signed the written informed consent
The patients present with operable unilateral invasive breast cancers without distant metastasis(stage I, II, and III)
The breast tumor's positive ER/PR rate is <1%, and positive ER-beta1 rate is =10% by IHC.
The patients have no history of neoadjuvant hormone therapy.
The patients have normal cardiac functions by echocardiography.
The patients' ECOG scores are =0-2.
Female patient who is = 18yrs, and = 65yrs.
The patients are non-pregnant, and disposed to practice contraception during the whole trial.
The patients underwent neoadjuvant chemotherapy plus surgery or directly modified radical mastectomy or breast-conserving surgery (plus sentinel lymph node biopsy or axillary lymph node dissection) after diagnosis of breast cancer.
The patients underwent chemotherapy, radiation therapy or targeted therapy(herceptin) after surgery according to the 2013 NCCN guideline.
The results of patients' blood tests are as follows:
{"Condition": ["breast cancers", "breast tumor", "distant metastasis", "normal cardiac functions"], "Device": [], "Drug": ["herceptin"], "Measurement": ["ECOG scores", "positive ER-beta1 rate", "positive ER/PR rate", "stage"], "Mood": [], "Multiplier": [], "Negation": ["no history", "without"], "Observation": [], "Person": ["Female"], "Procedure": ["neoadjuvant chemotherapy", "echocardiography", "axillary lymph node dissection", "sentinel lymph node biopsy", "surgery", "chemotherapy", "IHC", "radical mastectomy", "breast-conserving surgery", "neoadjuvant hormone therapy", "radiation therapy", "targeted therapy"], "Qualifier": ["2013 NCCN guideline", "operable", "invasive", "unilateral", "directly modified"], "ReferencePoint": ["diagnosis of breast cancer", "surgery"], "Scope": ["neoadjuvant chemotherapy plus surgery", "= 18yrs, and = 65yrs", "positive ER/PR rate is \u003c1%, and positive ER-beta1 rate is =10%", "chemotherapy, radiation therapy or targeted therapy(herceptin)", "neoadjuvant chemotherapy plus surgery or directly modified radical mastectomy or breast-conserving surgery (plus sentinel lymph node biopsy or axillary lymph node dissection)", "without distant metastasis"], "Temporal": ["after surgery", "after diagnosis of breast cancer"], "Value": ["I, II, and III", "= 18yrs", "=0-2", "\u003c1%", "=10%", "= 65yrs"], "Visit": []}