You will be shown inclusion or exclusion criteria for a clinical trial. Given these criteria, your task is to extract all unique entities of the following types: ["Observation", "Condition", "Procedure", "Drug", "Temporal", "Multiplier", "Qualifier", "Negation", "ReferencePoint", "Scope", "Value", "Mood", "Device", "Visit", "Measurement", "Person"].

Please return the output as a JSON object of the format: {"Condition" : ["breast cancer", ...], "Device" : ["ports", ...], "Drug" : ["Atenolol", ...], "Measurement" : ["blood pressure", ...], "Mood" : ["suspected", ...], "Multiplier" : ["more than two", ...], "Negation" : ["no", ...], "Observation" : ["history", ...], "Person" : ["male", ...], "Procedure" : ["surgery", ...], "Qualifier" : ["severe", ...], "ReferencePoint" : ["enrollment", ...], "Scope" : ["infection", ...], "Temporal" : ["one day", ...], "Value" : ["50%", ...], "Visit" : ["ICU", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Diagnosis of sickle cell disease 
Clinically significant disease defined as at least 1 painful episode per year averaged over the previous 3 years or a history of priapism, stroke, acute chest syndrome, avascular necrosis, multi-organ failure or the need for chronic narcotic medications for pain from sickle cell disease 
Must have failed a previous attempt at treatment with hydroxyurea defined as the inability to achieve a significant absolute increase in % fetal hemoglobin or the inability to tolerate hydroxyurea treatment due to severe side effects such as but not limited to myelosuppression, gastrointestinal symptoms, edema or hepatic enzyme elevations or have contraindications to hydroxyurea 
18 years of age or older 
Hematologic laboratory values as outlined in the protocol 
Non-hematologic laboratory values as outlined in the protocol 
Must agree not to donate blood or other bodily fluid while taking the study drug and for 28 days thereafter 
Women of child-bearing potential (WCBP) must have a negative serum pregnancy test 72 hours or less prior to starting treatment 
Women of child-bearing potential and men must agree to use 2 forms of adequate contraception prior to study entry and for the duration of study participation
{"Condition": ["pain", "sickle cell disease", "child-bearing potential", "avascular necrosis", "Clinically significant disease", "multi-organ failure", "painful episode", "priapism", "acute chest syndrome", "stroke"], "Device": [], "Drug": ["narcotic medications", "study drug"], "Measurement": ["serum pregnancy test"], "Mood": ["need for", "Diagnosis", "must agree to", "Must agree to"], "Multiplier": ["per year averaged over the previous 3 years at least 1", "chronic", "2 forms"], "Negation": ["not"], "Observation": ["history"], "Person": ["Women", "men", "age", "WCBP"], "Procedure": ["donate blood", "donate bodily fluid", "contraception", "treatment"], "Qualifier": ["adequate", "averaged over the previous 3 years", "chronic", "Clinically significant"], "ReferencePoint": ["taking the study drug", "starting treatment", "study entry", "study participation"], "Scope": ["Women of child-bearing potential", "while taking the study drug and for 28 days thereafter", "Women of child-bearing potential and men", "Women of child-bearing potential (WCBP)", "donate blood or other bodily fluid", "at least 1 painful episode per year averaged over the previous 3 years or a history of priapism, stroke, acute chest syndrome, avascular necrosis, multi-organ failure or the need for chronic narcotic medications for pain from sickle cell disease"], "Temporal": ["for the duration of study participation", "for 28 days thereafter", "72 hours or less prior to starting treatment", "the previous 3 years", "while taking the study drug", "prior to study entry"], "Value": ["18 years or older", "negative"], "Visit": []}