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tumors of the smooth muscle are rare in the head and neck region especially the buccal mucosa due to the scarcity of this tissue in this region and thus are frequently seen in the gastrointestinal and female genital tract because of the preponderance of smooth muscle at these sites . in the head and neck region , these tumors are believed to arise from the tunica media of the blood vessels .
clinically , they are very aggressive , and the prognosis is poor . in the oral cavity
most of the cases are seen in the mandible , maxilla , tongue , cheek , hard and soft palate , floor of the mouth and lip .
a 35-year - old female presented with difficulty in opening the mouth since past 1 month . on clinical examination an ulcerative lesion on the left buccal mucosa adjacent to the maxillary left third molar was observed .
the lesion was non - tender and firm in consistency , measuring about 1  1 cm in dimension , with inflamed surrounding margins .
an axial computed tomography scan showed an iso - dense mass in the right buccal mucosal region causing the swelling [ figure 1 ] .
excisional biopsy was done under local anesthesia , and the formalin fixed specimen was processed for histopathological examination .
the cells showed cellular and nuclear pleomorphism , increased mitotic figures , and prominent nucleoli .
single and multinucleated giant cells containing dark eosinophilic cytoplasm in a myxomatous connective tissue were also observed .
immunohistochemical staining showed strong positivity for vimentin [ figure 3 ] , smooth muscle actin ( sma ) [ figure 4 ] , and high proliferative index displayed by ki-67 [ figure 5 ] .
these immunohistochemical findings satisfy the criteria for leiomyosarcoma . due to loss of follow - up further treatment of the patient
an axial computed tomography scan showing an iso - dense mass in the right buccal mucosal region causing facial swelling photomicrograph showing interlacing fascicles and bundles of spindle cells ( h and e , 100 ) photomicrograph showing immunopositivity for vimentin ( original magnification 400 ) photomicrograph showing immunopositivity for smooth muscle actin ( original magnification 400 ) photomicrograph displaying proliferative activity by ki-67 ( 200 )
the literature review of primary leiomyosarcoma of the oral cavity in past 20 years retrieved is listed in table 1 .
the most frequent site was mandible accounting for 20 cases , followed by maxilla 15 cases , 10 cases in tongue and 9 cases in buccal mucosa , 2 each in lip , floor of the mouth , hard palate , soft palate and maxillary sinus .
out of 63 patients , 33 patients were male ( 56% ) and 30 were female ( 44% ) [ figure 6 ] .
prognostically , 28 cases were alive with no disease during the follow - up period which ranged from 6 months to 120 months .
twenty - one patients died of this disease during the follow - up period which ranged from 1 month to 37 months .
information was not available for nine patients who were lost during the follow - up and remaining three cases died of other causes .
data of primary oral lms from the english literature graph showing sex distribution of primary oral leiomyosarcomas soft tissue sarcomas are relatively rare neoplasms that may arise in any anatomic region .
occurrence in the head and neck accounts for less than 1% of all malignant tumors in this site .
only 3 - 10% of leiomyosarcoma ( lms ) cases arise in the head and neck [ figure 7 ] .
smooth muscles is sparse in the head and neck region and are mainly found in the walls of blood vessels , erector pili musculature of the skin , circumvallate papillae and myoepithelial cells of the salivary glands .
clinically most often lms presents as a nodular painless , well circumscribed mass , adherent firmly to the surrounding tissues which sometimes may be ulcerated as was in our presented case .
histologically lms typically displays spindle cells with abundant cytoplasm and centrally placed blunt ended cigar shaped nuclei of varying sizes .
microscopic criteria for well differentiated lms include : ( i ) a pattern of interlacing bundles of smooth muscle cells , ( ii ) a high mitotic rate , ( iii ) pleomorphism , and ( iv ) bizarre cell forms .
immunopositivity for vimentin , sma , and muscle specific actin msa has been demonstrated in lms .
the tumor should be immunonegative for s-100 and cytokeratins these histopathological features along with immunohistochemical profiles aids in differentiating lms from other similar spindle cell malignancies like malignant fibrous histiocytoma , fibrosarcoma , etc .
graph showing sites of occurrence of primary oral leiomyosarcomas differential diagnosis and immunohistochemical profile of similar spindle cell tumors oral lms tend to metastasize to the cervical nodes and lungs , and therefore when lms is identified , it is necessary to determine whether the lesion is primary or secondary .
the likelihood of distant metastasis is related to histologic grade and tumor size ; the risk is highest for large , high grade lesions . because of its similarity to other sarcomas composed of spindle cells like fibrosarcoma , neurogenic sarcoma and malignant fibrous histiocytoma , use of special stains and immunohistochemistry becomes of utmost importance for early diagnosis and prompt management of the cases .
early wide surgical excision with radical neck dissection for lymph node metastasis remains the mainstay of treatment .
overall the prognosis of lms is poor and hence early diagnosis is the key to the management .
oral lms are rare lesions of the head and neck with aggressive behavior and poor prognosis in most of the cases .
early and accurate diagnosis followed by radical treatment is of utmost importance for improving the prognosis of these tumors .
leiomyosarcoma ( lms ) is an uncommon malignant spindle cell tumor of the head and neck region . 
 the occurrence is particularly rare in the buccal mucosa of the oral cavity . 
 it is a rapidly growing tumor with aggressive behavior and poor prognosis . 
 method : this article presents a rare case of primary leimyosarcoma of the buccal mucosa in a 35 year old female and retrospective analysis of primary oral lms published in the english literature since past 20 years is done . 
 diagnosis was confirmed by immunohistochemistry profile showing positivity for vimentin , smooth muscle actin ( sma ) , high proliferative index displayed by ki-67 , focal positivity for pan - ck and negativity for s-100 . 
 conclusion : based on the presence of malignant spindle cells showing positivity for vimentin and sma , a diagnosis of leiomyosarcoma was made .