Given an abstract from a research paper, your task is to identify and label relationships between chemical compounds and genes mentioned in the abstract.

The relationship type must be one of ['DOWNREGULATOR', 'SUBSTRATE', 'INDIRECT-REGULATOR', 'PART-OF', 'MODULATOR-ACTIVATOR', 'REGULATOR', 'INHIBITOR', 'COFACTOR', 'UPREGULATOR', 'ACTIVATOR', 'ANTAGONIST', 'NOT', 'INDIRECT-DOWNREGULATOR', 'SUBSTRATE_PRODUCT-OF', 'INDIRECT-UPREGULATOR', 'AGONIST', 'PRODUCT-OF', 'MODULATOR', 'DIRECT-REGULATOR', 'UNDEFINED', 'AGONIST-INHIBITOR', 'AGONIST-ACTIVATOR', 'MODULATOR-INHIBITOR'].

Please format your output as a JSON array. Each entry in the array should express a single relation, formatted as ["<Entity_A>", "<RELATION_A_B>", "<Entity_B>"]. If no relations can be found, please output an empty JSON array [].

Abstract:

Amantadine induces c-fos in rat striatum: reversal with dopamine D1 and NMDA receptor antagonists. Amantadine (1-aminoadamantane) induced Fos expression in the central, dorsal-medial and ventral-medial part of the striatum. The distribution pattern of Fos induced by amantadine was more similar to those seen with dopaminomimetics than with N-methyl-D-aspartate (NMDA) receptor antagonists. Pretreatment with the dopamine D1 receptor antagonist, SCH23390, and the NMDA receptor antagonist, MK-801, blocked amantadine induction of Fos in the striatum. However, amantadine induction of Fos in the striatum was unaffected by the dopamine D2 receptor antagonist, sulpiride. These results suggest that amantadine induction of Fos in the rat striatum is related to dopamine D1 and NMDA receptors.
[["amantadine", "INDIRECT-UPREGULATOR", "Fos"], ["MK-801", "INDIRECT-DOWNREGULATOR", "Fos"], ["1-aminoadamantane", "INDIRECT-UPREGULATOR", "Fos"], ["Amantadine", "INDIRECT-UPREGULATOR", "Fos"], ["SCH23390", "ANTAGONIST", "dopamine D1 receptor"], ["Amantadine", "INDIRECT-UPREGULATOR", "c-fos"], ["sulpiride", "NOT", "Fos"], ["MK-801", "ANTAGONIST", "NMDA receptor"], ["SCH23390", "INDIRECT-DOWNREGULATOR", "Fos"], ["amantadine", "INDIRECT-REGULATOR", "NMDA receptors"], ["sulpiride", "ANTAGONIST", "dopamine D2 receptor"]]