You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["Outcome", "Participant", "Intervention"].

Please return the output as a JSON object of the format: {"Participant" : ["patients with COPD", ...], "Intervention" : ["Atenolol", ...], "Outcome" : ["blood pressure", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Six-month trial of on-demand rabeprazole 10 mg maintains symptom relief in patients with non-erosive reflux disease . BACKGROUND Compliance studies have shown that patients with reflux symptoms generally take their medication only when experiencing these symptoms . AIM To evaluate the efficacy of on-demand rabeprazole maintenance therapy in patients with non-erosive reflux disease . METHODS This multicentre , randomized , double-blind , placebo-controlled , withdrawal study compared 6 months of on-demand treatment with rabeprazole 10 mg vs. placebo . Adults with a history of reflux symptoms , a negative endoscopy , and > or = 3 days of moderate to very severe heartburn in the 7 days before enrollment ( N = 535 ) entered 4 weeks of open-label , acute treatment with rabeprazole 10 mg once daily . Patients with complete symptom relief then entered the on-demand phase . The primary end-point was discontinuation due to lack of heartburn control during the on-demand phase . RESULTS Eighty-three percent ( 432 of 523 ) of patients reported complete symptom relief at the end of the acute phase . During on-demand treatment , rates of discontinuation because of inadequate heartburn control were 20 % ( 28 of 139 ) for placebo vs. 6 % ( 16 of 279 ) for rabeprazole ( P < 0.00001 ) . Antacid use was twofold higher in the placebo group vs. the rabeprazole group ( P = 0.0009 ) . CONCLUSIONS Rabeprazole 10 mg once daily is highly effective in acute symptom relief and as on-demand long-term maintenance therapy in non-erosive reflux disease patients .
{"Intervention": ["Rabeprazole", "placebo", "placebo-controlled", "rabeprazole"], "Outcome": ["discontinuation due to lack of heartburn control during the on-demand phase", "rates of discontinuation because of inadequate heartburn control", "efficacy", "reflux disease", "effective", "Antacid use", "acute symptom relief", "symptom relief"], "Participant": ["non-erosive reflux disease", "Adults", "reflux", "heartburn", "patients with reflux symptoms"]}