You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["HealthCareActivity", "InjuryOrPoisoning", "BodySubstance", "IntellectualProduct", "AnatomicalStructure", "SpatialConcept", "Chemical", "Bacterium", "MedicalDevice", "Organization", "BiomedicalOccupationOrDiscipline", "Finding", "BiologicFunction", "Virus", "ResearchActivity", "ClinicalAttribute", "PopulationGroup", "Eukaryote", "BodySystem", "Food", "ProfessionalOrOccupationalGroup"].

Please return the output as a JSON object of the format: {"Virus": ["HIV", ...], "Bacterium": ["MRSA", ...], "AnatomicalStructure": ["Lung", ...], "BodySystem": ["CNS", ...], "BodySubstance": ["Serum", ...], "Finding": ["Headache", ...], "InjuryOrPoisoning": ["Fracture", ...], "BiologicFunction": ["Death", ...], "HealthCareActivity": ["Biopsy", ...], "ResearchActivity": ["Clinical trial", ...], "MedicalDevice": ["Lenses", ...], "SpatialConcept": ["Camps", ...], "BiomedicalOccupationOrDiscipline": ["Forensic medicine", ...], "Organization": ["WHO", ...], "ProfessionalOrOccupationalGroup": ["Provider", ...], "PopulationGroup": ["Swimmers", ...], "Chemical": ["Gold", ...], "Food": ["Rice", ...], "IntellectualProduct": ["RPAM", ...], "ClinicalAttribute": ["Biomarker", ...], "Eukaryote": ["Dogs", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

HOST IMMUNE RECOGNITION OF THE EPIDEMIC CYSTIC FIBROSIS PATHOGEN BURKHOLDERIA DOLOSA Burkholderia dolosa caused an outbreak in the cystic fibrosis (CF) clinic at Boston Children's Hospital from 1998 to 2005 and led to the infection of over 40 patients, many of whom died due to complications from infection by this organism. To assess whether B. dolosa significantly contributes to disease or is recognized by the host immune response, mice were infected with a sequenced outbreak B. dolosa strain, AU0158, and responses compared to the well-studied CF pathogen, Pseudomonas aeruginosa In parallel, mice were also infected with a polar flagellin mutant of B. dolosa to examine the role of flagella in B. dolosa lung colonization. The results showed a higher persistence in the host by B. dolosa strains and yet neutrophil recruitment and cytokine production were lower compared to P. aeruginosa The ability of host immune cells to recognize B. dolosa was then assessed and B. dolosa induced a robust cytokine response in cultured cells and this effect was dependent on the flagella only when bacteria were dead. Together, these results suggest that B. dolosa can be recognized by host cells in vitro but may avoid or suppress the host immune response in vivo through unknown mechanisms. B. dolosa was then compared to other Burkholderia species and found to induce similar levels of cytokine production despite being internalized by macrophages more than B. cenocepacia strains. These data suggest that B. dolosa AU0158 may act differently with host cells and is it recognized differently by immune systems compared other Burkholderia strains or species.
{"AnatomicalStructure": ["flagella", "lung", "host cells", "macrophages", "cultured cells", "flagellin", "neutrophil", "immune cells"], "Bacterium": ["Pseudomonas aeruginosa", "AU0158", "B. cenocepacia strains", "B. dolosa AU0158", "B. dolosa", "Burkholderia species", "BURKHOLDERIA DOLOSA", "organism", "B. dolosa strain", "bacteria", "Burkholderia strains", "P. aeruginosa", "B. dolosa strains", "Burkholderia dolosa"], "BiologicFunction": ["infection", "cystic fibrosis", "died", "disease", "immune response", "CYSTIC FIBROSIS", "complications", "CF", "persistence", "mutant", "dead", "IMMUNE RECOGNITION"], "BiomedicalOccupationOrDiscipline": [], "BodySubstance": [], "BodySystem": ["immune systems"], "Chemical": ["cytokine"], "ClinicalAttribute": [], "Eukaryote": ["mice"], "Finding": ["infected", "colonization"], "Food": [], "HealthCareActivity": [], "InjuryOrPoisoning": [], "IntellectualProduct": ["species"], "MedicalDevice": [], "Organization": ["Boston Children\u0027s Hospital"], "PopulationGroup": [], "ProfessionalOrOccupationalGroup": [], "ResearchActivity": [], "SpatialConcept": ["in vivo"], "Virus": []}