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Paper text:
in 2014 , a group of ap laboratory management experts convened as an advisory board for industry .
the group realized the expansive potential to improve ap laboratory management practices and rapidly assumed a new independent identity from that of an advocacy group ; this new group called itself the initiative for anatomic pathology laboratory patient safety ( iaplps ) .
the group consisted of highly involved internationally recognized experts in ap laboratory organization , including pathologists , a laboratory administrator , and a pathology assistant .
their first position statement was published in march 2014 , calling for an international effort to secure safe , reliable processing of all patient specimens for diagnosis .
members of this group pooled the experiences of their respective institutions to identify and rank a comprehensive list of steps that they perceived to represent patient risk within the ap laboratory workflow .
all 47 metrics were subject to discussion before members reached a consensus on relative risk .
individual members were electronically surveyed with regard to grading each metric as too high , intermediate , or low risk for likelihood of adverse patient outcome .
however , a group of intermediate - risk measures was not distinguishable , thus leading to a final separation consisting of only high and low risk categories .
globally harmonized practices and processes within the ap laboratory helped to generate this set of metrics .
this list is different from q - probes criteria or other checklists because it consists of workflow activities that influence risk to patient care and not only standard quality and efficiency .
the list specifically focuses on safety threats in the ap laboratory and does not include potential patient safety threats from pathologist interpretative errors because professional training and remediation better address these risks .
the scope also excludes preanalytic processes not directly controlled within the ap laboratory , such as specimen handling in the surgical or operating suite .
pathologist interpretation and ap laboratory specimen sourcing remain important issues for future investigation but are not within the scope of this research project .
the list in figure 1 consists of the final set of 47 metrics generated by members of the iaplps .
the 3 categories of ap laboratory processing are preanalytic , analytic , and postanalytic ; together , these categories contain 10 independent subprocesses .
figure 1 identifies 26 of 47 metrics as high risk ( shown in red ) and 21 as low risk ( in black ) . 

figure 1list of the anatomic pathology laboratory workflow metrics surveyed as being high risk and low risk for adverse patient outcomes . within each category ,
the metrics are listed ( alphabetically ) , and all 47 process metrics are listed numerically according to the entire workflow sequence .
list of the anatomic pathology laboratory workflow metrics surveyed as being high risk and low risk for adverse patient outcomes . within each category ,
the metrics are listed ( alphabetically ) , and all 47 process metrics are listed numerically according to the entire workflow sequence
. exhaustive discussion of this grading led us to realize that in extraordinarily rare circumstances , almost any step in the ap laboratory could lead to an adverse patient event .
for example , although typographical discrepancies in the final report usually only pose a minor threat to misdiagnosis , the remote possibility exists that mislabeling can result in a serious medical misdiagnosis .
however , although some metrics raise potential severe patient safety concerns , in most instances , even in riskier steps , laboratory professionals avoided actual adverse events by means of early detection . 

figure 1 indicates that we identified high and low risk processes in all 3 phases .
based on this list , the preanalytic phase had 9 possible deficiencies for safety in workflow , of which 4 were designated as high risk .
three metrics listed in the accessioning process were classified as high risk , and 3 others were considered to present low risk to patient care .
an example of a high risk scenario is when an inadequate amount of fixative jeopardizes the specimen integrity and results in the need for another biopsy .
some low risk process deficiencies listed have mild consequences , requiring only remedial efforts for resolution , such as correct pathologist case assignment .
other deficiencies , such as mislabeling errors , may be resolved immediately further down the stepwise sequence with limited consequences .
however , most of the metrics listed in this article are capable of generating an adverse patient outcome if not properly addressed .
the histotechnology committee affiliated with cap and the national society for histotechnology ( nsh ) has recently updated a guidance document called the practical guide to specimen handling in surgical pathology .
this committee reports to the council on scientific affairs and currently contains 14 members , of which 6 are cap fellows and 8 are certified histotechnologists and american society for clinical pathology ( ascp ) certified .
the purpose of the committee is to provide technical information for the improvement of laboratory processes . the specimen handling guideline publication not only identifies process deficiencies but also provides literature to support the entire workflow .
the publication also discusses patient safety issues , with the intention to bring about awareness of the practical guide to specimen handling .
it is an extensive report of the types of errors in workflow that can occur in the ap laboratory , which could compromise the quality of the specimen .
strict criteria for specimen procurement transfer are described in the guide , stating that all containers for specimen material should be rigid , impermeable , unbreakable , and nonreactive to fixative solutions .
also reported are the fixative programs for tissue processing , with references to peer - reviewed manuscripts and to proper waste - management documents .
however , its content is extensive and is not limited to processes with direct impact on patient care , unlike our metrics list , which focuses on high - risk issues . 

figure 1 suggests that the lengthy analytic phase contains multiple processes associated with the potential for high risk to patients . features such as processing , staining , and coverslipping specifically contain high risk metrics .
similar to those in the preanalytic phase , most metrics in the analytic phase have the potential to lead to misdiagnosis , if not carefully designed and monitored .
possible solutions to reduce error include advanced automation using individual slide - staining technology and coverslipping , to avoid any cross - contamination among specimens .
the potential for error associated with the processing subgroup can be readily addressed with implementation of best practices .
specifically , adhering to proper sequence timing ( ie , incorporating tissue type specifications ) and performing maintenance of fresh stock reagents will greatly minimize risk . as highlighted in the final phase of the ap laboratory workflow , the postanalytic phase contains 2 distinct subprocesses . within these ,
6 of the 9 metrics are high risk , indicating that some are closely associated with patient safety .
the first process was the pathologist sign - out and the second was grouping of intraoperative procedures associated with frozen sections .
similar to the previous phases , some metrics listed under pathologist sign - out can be corrected with use of automated equipment .
for example , the metric of dictation case mismatch can be resolved if the pathologist report is electronically integrated with audio - file compatibility , thus synchronizing the report with the dictation .
some metrics listed in figure 1 may have established , relatively simple solutions , but others continue to present challenges , which calls for a worldwide effort to compile error data before construction of best practices .
management of the ap laboratory requires a dedicated effort from health care staff and pathologists , to avoid diagnostic error and patient mismanagement .
the challenge is to obtain measureable quality improvements in specimen workflow , reducing risk of adverse outcomes in patient care .
the metrics list generated in this study is a comprehensive tool for standardizing collection of quality metrics , derived from pooled experience and expertise .
the metrics list , in combination with collection of error data , allows a comprehensive approach to initiate an engaged collaborative dialogue and to reduce risk of adverse outcomes from the ap laboratory workflow .
ultimately , doing this will require support and participation from patient care areas outside the laboratory , particularly those submitting tissue specimens .
surgical suites and other sites , such as gastrointestinal endoscopic and gynecologic clinics , would need to be involved .
implicit in such a scenario is the direct support of health care facility officers , patient safety officers , and other stakeholders , possibly even including patients .
the key objective of the iaplps in publishing this list of 47 metrics is to increase data collection regarding workflow deficiencies . in the past few decades since the release of the iom report
, several individual laboratories in the academic and private sectors have published their collection of error data . however , to our knowledge , only our report contains a list of error metrics composed by a team of global experts from 6 different countries .
the metrics listed herein are universal and more comprehensive than those represented in the q - probes survey , as well as being inclusive of intraoperative - procedure components .
this list of metrics also requires a proactive style of management for improvement of the ap laboratory workflow systems . because specimen procurement is the beginning of the workflow , it is essential for harmonious cooperation to take place during that step among nonlaboratory health care professionals and institutional administrators
also , the metrics include risks with pathologist interpretation that continue to remind pathologists to integrate with the ap laboratory workflow before receipt of diagnostics slides . in the past ,
individual laboratories have attempted to borrow management practices from other fields , such as the lean principles . some have utilized the concept of lean production methods to streamline and quantitate error data into measurable metrics within the ap laboratory with positive results .
also , not all laboratories have the resources to approach all 47 metrics at once ; more data would be beneficial in selecting solutions that are high in priority but low in cost .
grading of the metrics into higher and lower risk allows prioritization for lower initial cost expenditures .
the set of metrics that we present herein will provide a framework from which management can collect data and justify the cost of implementing quality improvement systems .
many of the metrics listed herein are more readily resolved with the installation of advanced technology , such as barcode readers , specimen - tracking instruments , computerized organizational systems , or advanced automated staining systems . however , in some instances , simple solutions are just as effective .
for example in a recent report from the department of dermatology at duke university medical center , misplacement of patient biopsy specimens was identified as a major problem within the workflow .
requiring attachment of a sticker to each specimen container , along with the initials of the person who had performed the specimen - retrieval procedure , reduced the error rate from 5.79 to 3.53 per 1000 cases .
thus , by increasing traceable individual accountability , the laboratory achieved dramatic improvement in an area of critical risk to patient safety .
the iaplps group hopes that the list of metrics provided in this article will streamline attempts to create effective interinstitutional best practices for ap laboratories .
our goal is to stimulate interest in widespread use of these metrics to encourage standardized , revolutionary safety - management approaches in the laboratory .
the initial collaboration of authors began as a corporate advisory board , in which ventana medical systems inc , a member of the roche group , compensated the members for their attendance .
subsequently , the authors formed the initiative for anatomic pathology laboratory patient ( iaplps ) and creation of these metrics , and any other continued autonomous effort is voluntary and uncompensated .
background : anatomic pathology laboratory workflow consists of 3 major specimen handling processes . among the workflow 
 are preanalytic , analytic , and postanalytic phases that contain multistep subprocesses with great impact on patient care . 
 a worldwide representation of experts came together to create a system of metrics , as a basis for laboratories worldwide , to help them evaluate and improve specimen handling to reduce patient safety risk . 
 
 method : members of the initiative for anatomic pathology laboratory patient safety ( iaplps ) pooled their extensive expertise to generate a list of metrics highlighting processes with high and low risk for adverse patient outcomes . 
 
 results : our group developed a universal , comprehensive list of 47 metrics for patient specimen handling in the anatomic pathology laboratory . 
 steps within the specimen workflow sequence are categorized as high or low risk . in general , steps associated with the potential for specimen misidentification correspond to the high - risk grouping and merit greater focus within quality management systems . 
 primarily workflow measures related to operational efficiency can be considered low risk . 
 
 conclusion : our group intends to advance the widespread use of these metrics in anatomic pathology laboratories to reduce patient safety risk and improve patient care with development of best practices and interlaboratory error reporting programs .