You will be shown inclusion or exclusion criteria for a clinical trial. Given these criteria, your task is to extract all unique entities of the following types: ["Observation", "Condition", "Procedure", "Drug", "Temporal", "Multiplier", "Qualifier", "Negation", "ReferencePoint", "Scope", "Value", "Mood", "Device", "Visit", "Measurement", "Person"].

Please return the output as a JSON object of the format: {"Condition" : ["breast cancer", ...], "Device" : ["ports", ...], "Drug" : ["Atenolol", ...], "Measurement" : ["blood pressure", ...], "Mood" : ["suspected", ...], "Multiplier" : ["more than two", ...], "Negation" : ["no", ...], "Observation" : ["history", ...], "Person" : ["male", ...], "Procedure" : ["surgery", ...], "Qualifier" : ["severe", ...], "ReferencePoint" : ["enrollment", ...], "Scope" : ["infection", ...], "Temporal" : ["one day", ...], "Value" : ["50%", ...], "Visit" : ["ICU", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

History of organic brain disease
DSM-IV diagnosis of Alcohol or Substance Dependence within the last six months (except nicotine) or DSM-5 diagnosis of Substance Use Disorder in the last six months (except nicotine)
DSM-IV diagnosis of Alcohol or Substance Abuse within the last one month (except nicotine) or DSM-5 diagnosis of Substance Use Disorder in the last six months (except nicotine)
Pregnancy or lactation
Severe liver dysfunction (LFT 3X upper limit of normal)
Previous known hypersensitivity to tetracyclines
Current treatment with tetracycline or derivative
Treatment with oral contraceptives (unless a second form of birth control is used and documented)
Treatment with cholestyramine or colestipol
Treatment with Urinary alkalinizers (e.g., sodium lactate, potassium citrate)
Treatment with warfarin
Treatment with bupropion, varenicline, or nicotine replacement products in the month prior to study inclusion
Less than two months treatment of adjunctive medications AND less than one month on same dose: beta blockers, antidepressants, mood stabilizers, antianxiety medications.
Medical condition whose pathology or treatment would significantly increase the risk associated with the proposed protocol.
History of head injury, seizures, or stroke
Positive urine toxicology screen for substances of non-therapeutic use prior to craving assessments
{"Condition": ["lcohol ependence", "Substance Abuse", "hypersensitivity", "liver dysfunction", "lactation", "Substance Dependence", "organic brain disease", "seizures", "cohol o use w", "head injury", "Substance Use Disorder", "Pregnancy", "stroke", "Medical condition"], "Device": [], "Drug": ["ycline or de tive\nTreat", "beta blockers", "antianxiety medications", "cholestyramine", "colestipol", "nicotine replacement products", "sodium lactate", "Urinary alkalinizers", "varenicline", "mood stabilizers", "bupropion", "nicotine", "tetracyclines", "antidepressants", "warfarin", "potassium citrate", "oral contraceptives", "tetracycline", "adjunctive medications"], "Measurement": ["urine toxicology screen", "LFT"], "Mood": [], "Multiplier": ["same dose", "Less than two months", "less than one month"], "Negation": ["unless", "except"], "Observation": ["History of", "History", "birth control"], "Person": [], "Procedure": ["treatment", "Treatment"], "Qualifier": ["DSM-5", "would significantly increase the risk associated with the proposed protocol", "Severe", "substances of non-therapeutic use", "second form", "DSM-IV"], "ReferencePoint": ["craving assessments", "study inclusion"], "Scope": ["tetracycline or derivative", "head injury, seizures, or stroke", "beta blockers, antidepressants, mood stabilizers, antianxiety medications", "bupropion, varenicline, or nicotine replacement products", "cholestyramine or colestipol", "LFT 3X upper limit of normal", "DSM-5 diagnosis of Substance Use Disorder in the last six months (except nicotine)", "Alcohol or Substance Abuse", "Alcohol or Substance Dependence", "sodium lactate, potassium citrate"], "Temporal": ["Previous", "Current", "in the last six months", "prior to craving assessments", "in the month prior to study inclusion", "within the last one month", "within the last six months"], "Value": ["Positive", "3X upper limit of normal"], "Visit": []}