You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["HealthCareActivity", "InjuryOrPoisoning", "BodySubstance", "IntellectualProduct", "AnatomicalStructure", "SpatialConcept", "Chemical", "Bacterium", "MedicalDevice", "Organization", "BiomedicalOccupationOrDiscipline", "Finding", "BiologicFunction", "Virus", "ResearchActivity", "ClinicalAttribute", "PopulationGroup", "Eukaryote", "BodySystem", "Food", "ProfessionalOrOccupationalGroup"].

Please return the output as a JSON object of the format: {"Virus": ["HIV", ...], "Bacterium": ["MRSA", ...], "AnatomicalStructure": ["Lung", ...], "BodySystem": ["CNS", ...], "BodySubstance": ["Serum", ...], "Finding": ["Headache", ...], "InjuryOrPoisoning": ["Fracture", ...], "BiologicFunction": ["Death", ...], "HealthCareActivity": ["Biopsy", ...], "ResearchActivity": ["Clinical trial", ...], "MedicalDevice": ["Lenses", ...], "SpatialConcept": ["Camps", ...], "BiomedicalOccupationOrDiscipline": ["Forensic medicine", ...], "Organization": ["WHO", ...], "ProfessionalOrOccupationalGroup": ["Provider", ...], "PopulationGroup": ["Swimmers", ...], "Chemical": ["Gold", ...], "Food": ["Rice", ...], "IntellectualProduct": ["RPAM", ...], "ClinicalAttribute": ["Biomarker", ...], "Eukaryote": ["Dogs", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Involvement of intracellular Zn(2+) signaling in LTP at perforant pathway - CA1 pyramidal cell synapse Physiological significance of synaptic Zn(2+) signaling was examined at perforant pathway - CA1 pyramidal cell synapses. In vivo long-term potentiation (LTP) at perforant pathway - CA1 pyramidal cell synapses was induced using a recording electrode attached to a microdialysis probe and the recording region was locally perfused with artificial cerebrospinal fluid (ACSF) via the microdialysis probe. Perforant pathway LTP was not attenuated under perfusion with CaEDTA (10 mM), an extracellular Zn(2+) chelator, but attenuated under perfusion with ZnAF-2DA (50 μM), an intracellular Zn(2+) chelator, suggesting that intracellular Zn(2+) signaling is required for perforant pathway LTP. Even in rat brain slices bathed in CaEDTA in ACSF, intracellular Zn(2+) level, which was measured with intracellular ZnAF-2, was increased in the stratum lacunosum-moleculare where perforant pathway - CA1 pyramidal cell synapses were contained after tetanic stimulation. These results suggest that intracellular Zn(2+) signaling, which originates in internal stores/ proteins, is involved in LTP at perforant pathway - CA1 pyramidal cell synapses. Because the influx of extracellular Zn(2+), which originates in presynaptic Zn(2+) release, is involved in LTP at Schaffer collateral - CA1 pyramidal cell synapses, synapse -dependent Zn(2+) dynamics may be involved in plasticity of postsynaptic CA1 pyramidal cells.
{"AnatomicalStructure": ["intracellular", "CA1 pyramidal cell synapse", "Perforant pathway", "CA1 pyramidal cell synapses", "CA1 pyramidal cells", "Schaffer collateral", "perforant pathway", "rat brain slices", "extracellular"], "Bacterium": [], "BiologicFunction": ["presynaptic Zn(2+) release", "signaling", "plasticity", "LTP", "synaptic Zn(2+) signaling", "long-term potentiation", "influx"], "BiomedicalOccupationOrDiscipline": [], "BodySubstance": [], "BodySystem": [], "Chemical": ["ZnAF-2DA", "Zn(2+)", "artificial cerebrospinal fluid", "CaEDTA", "ACSF", "proteins", "ZnAF-2"], "ClinicalAttribute": [], "Eukaryote": [], "Finding": [], "Food": [], "HealthCareActivity": ["tetanic stimulation", "perfusion", "microdialysis", "perfused"], "InjuryOrPoisoning": [], "IntellectualProduct": [], "MedicalDevice": ["probe", "electrode"], "Organization": [], "PopulationGroup": [], "ProfessionalOrOccupationalGroup": [], "ResearchActivity": [], "SpatialConcept": ["In vivo", "synapse"], "Virus": []}