You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["Outcome", "Participant", "Intervention"].

Please return the output as a JSON object of the format: {"Participant" : ["patients with COPD", ...], "Intervention" : ["Atenolol", ...], "Outcome" : ["blood pressure", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Dose-response characteristics during long-term inhalation of nitric oxide in patients with severe acute respiratory distress syndrome : a prospective , randomized , controlled study . Inhaled nitric oxide ( NO ) improves systemic oxygenation ( PaO2/FIO2 ) in adult patients with acute respiratory distress syndrome ( ARDS ) . However , individual response varies , and previous trials demonstrated no outcome benefit . This prospective , randomized study in 40 ARDS patients analyzed dose-response ( DR ) characteristics during long-term inhaled NO . Patients were randomized for conventional therapy ( control ) or continuous treatment with 10 parts per million ( ppm ) inhaled NO until weaning was initiated . We measured DR curves of PaO2/FIO2 versus the inhaled NO dose at regular intervals . Before treatment ( Day 0 ) , peak improvement in PaO2/FIO2 was achieved at 10 ppm for both control and NO-treated patients . After 4 days , the DR curve of the NO-treated patients was left shifted with a peak response at 1 ppm . At higher doses ( 10 and 100 ppm ) , oxygenation deteriorated , and the response to inhaled NO disappeared in several patients . This effect was not observed in the control group . There was no effect of inhaled NO on duration of mechanical ventilation or stay at the intensive care unit . In conclusion , long-term inhaled NO with constant doses of 10 ppm leads to enhanced sensitivity after several days and does do not allow reduction of ventilation parameters . Hence , previous trials on therapy with inhaled NO in ARDS should be carefully interpreted , as they used constant NO concentrations , which may have become overdoses leading to deterioration of oxygenation after several days .
{"Intervention": ["continuous treatment with 10 parts per million ( ppm ) inhaled NO", "nitric oxide ( NO )", "NO-treated", "conventional therapy ( control )", "nitric oxide", "NO"], "Outcome": ["mechanical ventilation or stay at the intensive care unit", "DR curve of the NO-treated patients", "dose-response ( DR ) characteristics", "PaO2/FIO2", "oxygenation deteriorated", "oxygenation", "DR curves of PaO2/FIO2 versus the inhaled NO dose"], "Participant": ["acute respiratory distress syndrome ( ARDS )", "severe acute respiratory distress syndrome", "adult", "40", "ARDS"]}