You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["HealthCareActivity", "InjuryOrPoisoning", "BodySubstance", "IntellectualProduct", "AnatomicalStructure", "SpatialConcept", "Chemical", "Bacterium", "MedicalDevice", "Organization", "BiomedicalOccupationOrDiscipline", "Finding", "BiologicFunction", "Virus", "ResearchActivity", "ClinicalAttribute", "PopulationGroup", "Eukaryote", "BodySystem", "Food", "ProfessionalOrOccupationalGroup"].

Please return the output as a JSON object of the format: {"Virus": ["HIV", ...], "Bacterium": ["MRSA", ...], "AnatomicalStructure": ["Lung", ...], "BodySystem": ["CNS", ...], "BodySubstance": ["Serum", ...], "Finding": ["Headache", ...], "InjuryOrPoisoning": ["Fracture", ...], "BiologicFunction": ["Death", ...], "HealthCareActivity": ["Biopsy", ...], "ResearchActivity": ["Clinical trial", ...], "MedicalDevice": ["Lenses", ...], "SpatialConcept": ["Camps", ...], "BiomedicalOccupationOrDiscipline": ["Forensic medicine", ...], "Organization": ["WHO", ...], "ProfessionalOrOccupationalGroup": ["Provider", ...], "PopulationGroup": ["Swimmers", ...], "Chemical": ["Gold", ...], "Food": ["Rice", ...], "IntellectualProduct": ["RPAM", ...], "ClinicalAttribute": ["Biomarker", ...], "Eukaryote": ["Dogs", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Effects of argan oil on the mitochondrial function, antioxidant system and the activity of NADPH - generating enzymes in acrylamide treated rat brain Argan oil (AO) is rich in minor compounds such as polyphenols and tocopherols which are powerful antioxidants. Acrylamide (ACR) has been classified as a neurotoxic agent in animals and humans. Mitochondrial oxidative stress and dysfunction is one of the most probable molecular mechanisms of neurodegenerative diseases. Female Sprague Dawley rats were exposed to ACR (50mg/kg i.p. three times a week), AO (6ml/kg,o.p, per day) or together for 30days. The activities of cytosolic enzymes such as xanthine oxidase (XO), glucose 6-phosphate dehydrogenase (G6PDH), glutathione-S-transferase (GST), mitochondrial oxidative stress, oxidative phosphorylation (OXPHOS) and tricarboxylic acid cycle (TCA) enzymes, mitochondrial metabolic function, adenosine triphosphate (ATP) level and acetylcholinesterase (AChE) activity were assessed in rat brain. Cytosolic and mitochondrial antioxidant enzymes were significantly diminished in the brains of rats treated with ACR compared to those in control. Besides, ACR treatment resulted in a significant reduction in brain ATP level, mitochondrial metabolic function, OXPHOS and TCA enzymes. Administration of AO restored both the cytosolic and mitochondrial oxidative stress by normalizing nicotinamide adenine dinucleotide phosphate (NADPH) generating enzymes. In addition, improved mitochondrial function primarily enhancing nicotinamide adenine dinucleotide (NADH) generated enzymes activities and ATP level in the mitochondria. The reason for AO's obvious beneficial effects in this study may be due to synergistic effects of its different bioactive compounds which is especially effective on mitochondria. Modulation of the brain mitochondrial functions and antioxidant systems by AO may lead to the development of new mitochondria - targeted antioxidants in the future.
{"AnatomicalStructure": ["Mitochondrial", "mitochondria", "Cytosolic", "mitochondrial", "cytosolic", "brains", "brain"], "Bacterium": [], "BiologicFunction": ["tricarboxylic acid cycle", "acetylcholinesterase (AChE) activity", "OXPHOS", "neurodegenerative diseases", "enzymes activities", "TCA", "metabolic function", "mitochondrial function", "targeted", "mitochondrial functions", "oxidative phosphorylation", "activity", "oxidative stress"], "BiomedicalOccupationOrDiscipline": [], "BodySubstance": [], "BodySystem": ["antioxidant system", "antioxidant systems"], "Chemical": ["NADPH", "enzymes", "antioxidant enzymes", "AO\u0027s", "nicotinamide adenine dinucleotide", "GST", "Acrylamide", "glutathione-S-transferase", "NADH", "acrylamide", "ATP", "AO", "Argan oil", "antioxidants", "xanthine oxidase", "XO", "adenosine triphosphate", "tocopherols", "nicotinamide adenine dinucleotide phosphate", "compounds", "G6PDH", "ACR", "polyphenols", "glucose 6-phosphate dehydrogenase", "argan oil"], "ClinicalAttribute": [], "Eukaryote": ["animals", "rat", "rats", "humans", "Sprague Dawley rats"], "Finding": ["improved", "dysfunction"], "Food": [], "HealthCareActivity": ["treatment", "Administration", "treated", "treated with"], "InjuryOrPoisoning": [], "IntellectualProduct": ["classified"], "MedicalDevice": [], "Organization": [], "PopulationGroup": [], "ProfessionalOrOccupationalGroup": [], "ResearchActivity": ["study", "normalizing"], "SpatialConcept": ["Modulation"], "Virus": []}