You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["HealthCareActivity", "InjuryOrPoisoning", "BodySubstance", "IntellectualProduct", "AnatomicalStructure", "SpatialConcept", "Chemical", "Bacterium", "MedicalDevice", "Organization", "BiomedicalOccupationOrDiscipline", "Finding", "BiologicFunction", "Virus", "ResearchActivity", "ClinicalAttribute", "PopulationGroup", "Eukaryote", "BodySystem", "Food", "ProfessionalOrOccupationalGroup"].

Please return the output as a JSON object of the format: {"Virus": ["HIV", ...], "Bacterium": ["MRSA", ...], "AnatomicalStructure": ["Lung", ...], "BodySystem": ["CNS", ...], "BodySubstance": ["Serum", ...], "Finding": ["Headache", ...], "InjuryOrPoisoning": ["Fracture", ...], "BiologicFunction": ["Death", ...], "HealthCareActivity": ["Biopsy", ...], "ResearchActivity": ["Clinical trial", ...], "MedicalDevice": ["Lenses", ...], "SpatialConcept": ["Camps", ...], "BiomedicalOccupationOrDiscipline": ["Forensic medicine", ...], "Organization": ["WHO", ...], "ProfessionalOrOccupationalGroup": ["Provider", ...], "PopulationGroup": ["Swimmers", ...], "Chemical": ["Gold", ...], "Food": ["Rice", ...], "IntellectualProduct": ["RPAM", ...], "ClinicalAttribute": ["Biomarker", ...], "Eukaryote": ["Dogs", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Association between XRCC1 and ERCC1 single-nucleotide polymorphisms and the efficacy of concurrent radiochemotherapy in patients with esophageal squamous cell carcinoma The aim of the present study was to investigate the association between single-nucleotide polymorphisms (SNPs) in X-ray repair cross-complementing 1-399 (XRCC1-399) or excision repair cross-complementation group 1-118 (ERCC1-118) and the short-term efficacy of radiochemotherapy, tumor metastasis and relapse, as well as the survival time in patients with esophageal squamous cell carcinoma (ESCC). TaqMan probe-based quantitative polymerase chain reaction (qPCR) was conducted to examine the levels of XRCC1-399 and ERCC1-118 SNPs in the peripheral blood of 50 patients with pathologically confirmed ESCC. In addition, the associations between different genotypes and short-term therapeutic efficacy [the complete remission (CR) rate], tumor metastasis and relapse, as well as the survival time following concurrent radiochemotherapy, were determined. A total of 50 ESCC patients who received concurrent radiochemotherapy were enrolled. It was found that the short-term therapeutic efficacy (CR rate) was higher in the group of patients carrying the homozygous mutation of XRCC1-399 (A / A genotype) than in the group of patients without the XRCC1-399 mutation (G / G genotype). In addition, the CR rate was significantly increased in patients carrying one or two ERCC1-118 C alleles (C / C or C / T genotype) compared with patients lacking the C allele (T / T genotype). The differences were statistically significant (A / A vs. G / G, P=0.014; T T vs. C / T + C / C, P=0.040). During the follow-up period, the group of patients carrying the homozygous mutation of XRCC1-399 (A / A genotype) exhibited a markedly reduced risk of metastasis and relapse compared with the group of patients carrying non-mutated XRCC1-399 (G / G genotype; P=0.031). By contrast, ERCC1-118 SNP was not associated with the risk of metastasis and recurrence (P>0.05). The combined results of univariate and multivariate Cox regression analysis showed that the SNP in ERCC1-118 was closely associated with survival time. The mean survival time was significantly prolonged in patients carrying 1 or 2 C alleles (C / C or C / T genotype) compared with patients lacking the C allele (T / T genotype) [T / T vs. C / C, HR =12.96, 95% confidence interval (CI)=3.08-54.61, P<0.001; T T vs. C / T + C / C, HR =11.71, 95% CI =3.06-44.83, P<0.001]. However, XRCC1-399 SNP had no effect on survival time (P>0.05). XRCCl-399 SNP was associated with the short-term therapeutic efficacy (the CR rate) and tumor metastasis / relapse in ESCC patients who received the docetaxel plus cisplatin (TP) regimen -based concurrent radiochemotherapy. By contrast, ERCC1-118 SNP was significantly associated with the short-term therapeutic efficacy (the CR rate) and survival time in ESCC patients who received TP regimen -based concurrent radiochemotherapy.
{"AnatomicalStructure": ["ERCC1", "excision repair cross-complementation group 1-118", "alleles", "allele", "X-ray repair cross-complementing 1-399", "XRCC1", "ERCC1-118", "XRCC1-399", "XRCCl-399"], "Bacterium": [], "BiologicFunction": ["homozygous mutation", "mutation", "metastasis", "tumor metastasis", "ESCC", "esophageal squamous cell carcinoma"], "BiomedicalOccupationOrDiscipline": [], "BodySubstance": ["peripheral blood"], "BodySystem": [], "Chemical": ["G", "T", "C", "A"], "ClinicalAttribute": ["survival time"], "Eukaryote": [], "Finding": ["follow-up period", "examine", "CR", "complete remission", "confirmed"], "Food": [], "HealthCareActivity": ["docetaxel plus cisplatin (TP) regimen", "TP regimen", "concurrent radiochemotherapy", "radiochemotherapy"], "InjuryOrPoisoning": [], "IntellectualProduct": ["multivariate Cox regression analysis"], "MedicalDevice": [], "Organization": [], "PopulationGroup": [], "ProfessionalOrOccupationalGroup": [], "ResearchActivity": ["TaqMan probe-based quantitative polymerase chain reaction", "qPCR"], "SpatialConcept": ["single-nucleotide polymorphisms", "SNP", "SNPs"], "Virus": []}