You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["Outcome", "Participant", "Intervention"].

Please return the output as a JSON object of the format: {"Participant" : ["patients with COPD", ...], "Intervention" : ["Atenolol", ...], "Outcome" : ["blood pressure", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Clarithromycin reduces the severity of bronchial hyperresponsiveness in patients with asthma . A randomised double-blind placebo-controlled study was designed to evaluate the effects of a semisynthetic macrolide antibiotic , clarithromycin , on bronchial hyperresponsiveness to methacholine in patients with a diagnosis of asthma . Adult asthma patients undergoing treatment with budesonide 400 microg b.i.d . and salbutamol 200 microg p.r.n . less than twice weekly were studied . Arm A ( 16 males/six females , aged 48 +/- 16 yrs ) received clarithromycin 250 mg b.i.d . for 8 weeks , arm B ( eight males/12 females , aged 42 +/- 12 yrs ) clarithromycin 250 mg t.id . and arm C ( six males/15 females , aged 41 +/- 16 yrs ) placebo dextrose tablets . Bronchial hyperresponsiveness was quantified by measurement of the provocative dose of methacholine causing a 20 % fall in forced expiratory volume in one second ( PD20 ) . Median ( interquartile range ) PD20 in the three groups before and after treatment with clarithromycin were : arm A : 0.3 ( 0.1-1 ) and 1.3 ( 0.6-2 ) mg ; arm B : 0.4 ( 0.1-0.9 ) and 2 ( 2-2 ) mg ; and arm C : 0.4 ( 0.1-0.9 ) and 0.3 ( 0.1-0.6 ) mg , respectively . Serum free cortisol levels were determined and remained unchanged from baseline in the clarithromycin-treated patients . It is concluded that clarithromycin reduces the degree of bronchial hyperresponsiveness in patients with asthma .
{"Intervention": ["salbutamol", "Clarithromycin", "clarithromycin", "placebo-controlled", "methacholine", "placebo dextrose", "clarithromycin-treated", "semisynthetic macrolide antibiotic"], "Outcome": ["degree of bronchial hyperresponsiveness", "provocative dose of methacholine", "severity of bronchial hyperresponsiveness", "Bronchial hyperresponsiveness was quantified", "evaluate the effects", "Serum free cortisol levels", "20 % fall in forced expiratory volume in one second ( PD20 ) . Median ( interquartile range ) PD20"], "Participant": ["males/six females", "males/12 females", "16", "Adult", "42 +/- 12", "eight", "clarithromycin-treated", "48 +/- 16", "asthma"]}