You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["HealthCareActivity", "InjuryOrPoisoning", "BodySubstance", "IntellectualProduct", "AnatomicalStructure", "SpatialConcept", "Chemical", "Bacterium", "MedicalDevice", "Organization", "BiomedicalOccupationOrDiscipline", "Finding", "BiologicFunction", "Virus", "ResearchActivity", "ClinicalAttribute", "PopulationGroup", "Eukaryote", "BodySystem", "Food", "ProfessionalOrOccupationalGroup"].

Please return the output as a JSON object of the format: {"Virus": ["HIV", ...], "Bacterium": ["MRSA", ...], "AnatomicalStructure": ["Lung", ...], "BodySystem": ["CNS", ...], "BodySubstance": ["Serum", ...], "Finding": ["Headache", ...], "InjuryOrPoisoning": ["Fracture", ...], "BiologicFunction": ["Death", ...], "HealthCareActivity": ["Biopsy", ...], "ResearchActivity": ["Clinical trial", ...], "MedicalDevice": ["Lenses", ...], "SpatialConcept": ["Camps", ...], "BiomedicalOccupationOrDiscipline": ["Forensic medicine", ...], "Organization": ["WHO", ...], "ProfessionalOrOccupationalGroup": ["Provider", ...], "PopulationGroup": ["Swimmers", ...], "Chemical": ["Gold", ...], "Food": ["Rice", ...], "IntellectualProduct": ["RPAM", ...], "ClinicalAttribute": ["Biomarker", ...], "Eukaryote": ["Dogs", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

TLR9 Deficiency Leads to Accelerated Renal Disease and Myeloid Lineage Abnormalities in Pristane -Induced Murine Lupus Systemic lupus erythematosus (SLE) is a chronic, life-threatening autoimmune disorder, leading to multiple organ pathologies and kidney destruction. Analyses of numerous murine models of spontaneous SLE have revealed a critical role for endosomal TLRs in the production of autoantibodies and development of other clinical disease manifestations. Nevertheless, the corresponding TLR9 - deficient autoimmune -prone strains consistently develop more severe disease pathology. Injection of BALB/c mice with 2,6,10,14-tetramethylpentadecane (TMPD), commonly known as pristane, also results in the development of SLE-like disease. We now show that Tlr9(-/-) BALB/c mice injected i.p. with TMPD develop more severe autoimmunity than do their TLR -sufficient cohorts. Early indications include an increased accumulation of TLR7 - expressing Ly6C(hi) inflammatory monocytes at the site of injection, upregulation of IFN -regulated gene expression in the peritoneal cavity, and an increased production of myeloid lineage precursors (common myeloid progenitors and granulocyte myeloid precursors) in the bone marrow. TMPD - injected Tlr9(-/-) BALB/c mice develop higher autoantibody titers against RNA, neutrophil cytoplasmic Ags, and myeloperoxidase than do TMPD - injected wild-type BALB/c mice. The TMP - injected Tlr9(-/-) mice, and not the wild-type mice, also develop a marked increase in glomerular IgG deposition and infiltrating granulocytes, much more severe glomerulonephritis, and a reduced lifespan. Collectively, the data point to a major role for TLR7 in the response to self-antigens in this model of experimental autoimmunity. Therefore, the BALB/c pristane model recapitulates other TLR7 -driven spontaneous models of SLE and is negatively regulated by TLR9.
{"AnatomicalStructure": ["Myeloid Lineage", "TLR9", "organ", "monocytes", "bone marrow", "granulocyte", "myeloid precursors", "granulocytes", "endosomal", "common myeloid progenitors", "TLR7", "neutrophil", "Tlr9(-/-)", "cytoplasmic", "myeloid lineage precursors", "kidney"], "Bacterium": [], "BiologicFunction": ["upregulation", "Systemic lupus erythematosus", "Lupus", "SLE-like disease", "models", "expressing", "autoimmune", "glomerulonephritis", "disease", "autoimmune disorder", "autoimmunity", "gene expression", "SLE)", "Renal Disease", "SLE", "model"], "BiomedicalOccupationOrDiscipline": ["pathology", "pathologies"], "BodySubstance": [], "BodySystem": [], "Chemical": ["RNA", "TLRs", "IFN", "2,6,10,14-tetramethylpentadecane", "myeloperoxidase", "glomerular IgG", "autoantibody", "self-antigens", "pristane", "autoantibodies", "Pristane", "Ly6C(hi)", "TMPD", "Ags", "TMP", "TLR"], "ClinicalAttribute": [], "Eukaryote": ["BALB/c", "wild-type mice", "mice", "wild-type BALB/c mice", "Murine", "murine", "BALB/c mice"], "Finding": ["Abnormalities", "accumulation", "negatively", "life-threatening"], "Food": [], "HealthCareActivity": ["injected", "Injection", "injected i.p."], "InjuryOrPoisoning": [], "IntellectualProduct": [], "MedicalDevice": [], "Organization": [], "PopulationGroup": [], "ProfessionalOrOccupationalGroup": [], "ResearchActivity": [], "SpatialConcept": ["site of injection", "peritoneal cavity"], "Virus": []}