You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["Outcome", "Participant", "Intervention"].

Please return the output as a JSON object of the format: {"Participant" : ["patients with COPD", ...], "Intervention" : ["Atenolol", ...], "Outcome" : ["blood pressure", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

MF101 , a selective estrogen receptor beta modulator for the treatment of menopausal hot flushes : a phase II clinical trial . OBJECTIVE To determine the optimal dose , safety , and efficacy of an estrogen receptor beta selective Chinese herbal extract , menopausal formula 101 ( MF101 ) , for treating hot flushes . METHODS A randomized , blinded trial in 217 postmenopausal women with hot flushes randomized to 5 or 10 g/day of MF101 or placebo for 12 weeks . RESULTS The effects of 5 g/day of MF101 did not differ from those of placebo . After 12 weeks , the mean percent decrease in frequency of hot flushes in the 10 g/day group was 12.9 % greater than that in the placebo group ( P = 0.15 ) , the median percent decrease was 11.7 % greater than that in the placebo group ( P = 0.05 ) , and the proportion of women with at least a 50 % reduction in hot flushes was 16.2 % greater than that in the placebo group ( P = 0.03 ) . CONCLUSIONS Treatment with 10 g/day of MF101 reduces the frequency of hot flushes . Trials with higher doses are planned .
{"Intervention": ["placebo", "estrogen receptor beta selective Chinese herbal extract", "MF101", "menopausal formula 101", "MF101 , a selective estrogen receptor"], "Outcome": ["proportion of women with at least a 50 % reduction in hot flushes", "mean percent decrease in frequency of hot flushes"], "Participant": ["women", "217", "postmenopausal", "hot flushes"]}