You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["HealthCareActivity", "InjuryOrPoisoning", "BodySubstance", "IntellectualProduct", "AnatomicalStructure", "SpatialConcept", "Chemical", "Bacterium", "MedicalDevice", "Organization", "BiomedicalOccupationOrDiscipline", "Finding", "BiologicFunction", "Virus", "ResearchActivity", "ClinicalAttribute", "PopulationGroup", "Eukaryote", "BodySystem", "Food", "ProfessionalOrOccupationalGroup"].

Please return the output as a JSON object of the format: {"Virus": ["HIV", ...], "Bacterium": ["MRSA", ...], "AnatomicalStructure": ["Lung", ...], "BodySystem": ["CNS", ...], "BodySubstance": ["Serum", ...], "Finding": ["Headache", ...], "InjuryOrPoisoning": ["Fracture", ...], "BiologicFunction": ["Death", ...], "HealthCareActivity": ["Biopsy", ...], "ResearchActivity": ["Clinical trial", ...], "MedicalDevice": ["Lenses", ...], "SpatialConcept": ["Camps", ...], "BiomedicalOccupationOrDiscipline": ["Forensic medicine", ...], "Organization": ["WHO", ...], "ProfessionalOrOccupationalGroup": ["Provider", ...], "PopulationGroup": ["Swimmers", ...], "Chemical": ["Gold", ...], "Food": ["Rice", ...], "IntellectualProduct": ["RPAM", ...], "ClinicalAttribute": ["Biomarker", ...], "Eukaryote": ["Dogs", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Effects of regular water - and land-based exercise on physical function after 5 years: A long-term study on the well-being of older Japanese adults To investigate the effects of 5 years of physical exercise on functional parameters among older Japanese adults who carried out water - or land-based exercise. We retrospectively investigated data from 5707 medical examinations and enrolled 77 older adults into the study. Eligible participants had to be aged ≥60 years, and engaged in water-based exercise (n = 38) or a combination of water - and land-based exercise (n = 39) for at least 80% of their total exercise time for over 5 years at our fitness center. In statistical analysis, a two-way repeated-measures analysis of variance was carried out to examine the effects over time and by exercise type, and the changes in each parameter over 5 years were also compared between the two groups. We found significant main effects and an interaction between time and exercise type for gait speed, with an early decline in the combined exercise group, as well as significant main effects of time, showing a functional decline in grip strength, one-leg standing time and step/height ratio in both exercise types at the 5- year follow up. The 5- year changes in each parameter did not differ between the two groups despite the frequency of exercise, even though we found a negative correlation between changes in one-leg standing time and total amount of water-based exercise. Contrary to expectations, these results suggest that regular engagement in water-based exercise, even combined with land-based exercise, might have poor long-term benefits for maintaining physical performance in older adults. Geriatr Gerontol Int 2017; ••: ••-••.
{"AnatomicalStructure": [], "Bacterium": [], "BiologicFunction": [], "BiomedicalOccupationOrDiscipline": [], "BodySubstance": [], "BodySystem": [], "Chemical": [], "ClinicalAttribute": [], "Eukaryote": [], "Finding": ["exercise type", "functional decline", "step/height", "physical function", "exercise types", "negative", "examine", "found", "frequency of exercise"], "Food": [], "HealthCareActivity": ["follow up", "enrolled", "medical examinations"], "InjuryOrPoisoning": [], "IntellectualProduct": [], "MedicalDevice": [], "Organization": ["fitness center"], "PopulationGroup": ["older adults", "older Japanese", "participants", "adults"], "ProfessionalOrOccupationalGroup": [], "ResearchActivity": ["study", "long-term study"], "SpatialConcept": ["one-leg standing"], "Virus": []}