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Paper text:
endoscopic band ligation ( ebl ) has been widely used for the treatment of gastrointestinal hemorrhage , such as that caused by varices , ulcers , and invasive endoscopic procedures .
it is advantageous for treating gastrointestinal perforations because it can be performed immediately after diagnosis and the required devices are commonly available in endoscopy units .
perforation is a rare complication of endoscopic retrograde cholangiopancreatography ( ercp ) , occurring in approximately 1% of cases ; however , the associated mortality rate is as high as 7.6% .
recently , several endoscopic closure techniques , such as the use of endoclips , endoloops , fibrin glue , and band ligation , have been introduced for perforation repair .
however , endoscopic methods have limitations if the perforation size is larger than 1.0 cm .
to overcome this limitation , techniques that involve the use of multiple endoclips and endoloops were introduced .
we report a case of successful repair of a 2.0-cm duodenal wall perforation , which was caused by an endoscopic tip during ercp , by performing double ebl and using an endoclip .
a 93-year - old woman presented to the emergency department with upper abdominal pain that began 5 days prior .
initial blood pressure , heart rate , respiratory rate , and body temperature were 140/90 mm hg , 115 beats per minute , 20 cycles per minute , and 38.5c , respectively . during physical examination , tenderness was noted in the right upper quadrant of the abdomen .
laboratory data were as follows : white blood cell count , 29,710 cells/l ; hemoglobin level , 9.9 g / dl ; platelet count , 163,000/ml ; aspartate aminotransferase , 341 iu / l ; alanine aminotransferase , 186 iu / l ; -glutamyltransferase , 586 iu / l ; alkaline phosphatase , 212 iu / l ; total bilirubin , 1.70 mg / dl ; and high - sensitivity c - reactive protein , 5.67 mg / dl .
abdominal computed tomography scan showed common bile duct dilatation with multiple stones in the bile duct and gallbladder .
acute cholangitis and acute cholecystitis due to gallstones were diagnosed , and ercp was performed .
while inserting the lateral endoscope from the duodenal bulb to the second portion of the duodenum , the existence of a perforation at the descending limb of the duodenum was suspected .
we immediately switched to a forward endoscope that had a transparent band apparatus and attempted to confirm the presence of the perforation at the suspected site .
a 2.0-cm oval - shaped perforation at the lateral duodenal wall was found , and peritoneal structures such as the mesenteries were observed in some areas of the perforation . a diagnosis of ercp - related perforation of the lateral duodenal wall was made , and repair of the perforation orifice with ebl was planned .
however , single band ligation is considered to be ineffective for the repair of a 2.0-cm perforation ; hence , double band ligation was attempted .
the first ebl was performed at the proximal edge of the perforation orifice , and two - thirds of the perforated site were repaired along with the adjacent normal duodenal structures . a second ebl was performed that included the contents covered by the first ligation .
considering the possibility of the existence of a residual perforation , an endoclip was applied at the distal end of the perforation . the diagnosis and repair of the perforation
although free air was not present , an air shadow was observed near the right kidney and retroperitoneal space on plain abdomen radiography performed after the procedure ( fig .
the patient complained of abdominal pain accompanied by persistent right upper quadrant tenderness , and treatment comprising the administration of analgesics , antibiotics , and intravenous fluids and bowel rest was initiated .
stay , abdominal pain and fever subsided , and other laboratory tests results were within the normal limits ( fig .
various endoscopic repair methods for iatrogenic perforations have been introduced because of the increase in the number of endoscopic procedures performed .
ebl , which was formerly indicated only for the management of gastrointestinal bleeding , is now widely used for perforation repair . in some cases ,
endoscopic clipping is impossible or insufficient owing to the size and location of the perforation , and in such cases ebl alone or in combination with endoclipping is performed . in general
, perforations are divided into three subtypes depending on the size : small , < 1 cm ; large , between 1 and 3 cm ; and giant , > 3 cm .
the biggest advantages of ebl are that it can be easily performed for perforations that are 1 to 2 cm in size regardless of the perforation site or angle and it can be performed immediately after the perforation is diagnosed .
multiple cases of successful endoscopic repair of esophageal perforations smaller than 1.0 or 1 to 2 cm in size in the stomach , duodenum , and colon have been reported recently .
the success rate for ebl is higher when it is performed in the colon , second to fourth duodenal portions , and small bowel than when it is performed in the stomach and duodenal bulb due to its thin bowel wall structure and thickness .
perforations associated with ercp are classified into four subtypes depending on the clinical severity , pathogenesis , anatomic position , and the need for surgery .
type i ( lateral and medial wall ) perforations caused by the endoscope tip require immediate surgery due to the clinical severity .
however , with rapid developments in endoscopic treatment methods and devices in recent years , products and techniques such as fibrin glue , endoloops , endoclips , over - the - scope clipping devices , purse - string sutures , and open - pore film drainage   have been introduced for treating type i perforations .
the frequency of surgical or nonsurgical repair depends on the perforation type . for type i perforations ,
81% are repaired surgically , whereas 79% of type ii ( perivaterian ) and 100% of type iii ( guide - wire associated ) or type iv ( retroperitoneal air alone ) perforations are repaired non - surgically . in this case , a better clinical course was achieved by immediate clinical suspicion of type i perforation , concurrent diagnosis and treatment with the use of a forward endoscope , and minimization of air and fluid leakage into the abdominal cavity .
complete ligation was achieved by double band ligation and endoclipping at the distal site although the perforation size was larger than the typical perforation size indication for ebl . because a better prognosis can be achieved with prompt repair ,
it is highly recommended to make a diagnosis by immediately switching to a forward endoscope with a band and transparent cap whenever perforation is suspected . when the endoscope band is applied to the forward endoscope
in addition , the endoscope band has the advantage that is readily available in endoscopy units and hence can be widely used for hemostasis . in this case , we performed ebl for a 2-cm perforation .
complete repair of a perforation larger than 2 cm can be achieved if ebl is started from the lateral edge and the length of perforation is shortened by applying additional ebls or hemoclipping sequentially to create a 
 in conclusion , when type i duodenal perforation is suspected during ercp , immediately switching to a forward endoscope with an endoscope band can aid in prompt diagnosis and repair of the perforation .
ebl could be used for large perforations by starting the repair from the lateral edge of the perforation site and applying additional band ligation or endoclipping if complete repair can not be achieved with single band ligation .
endoscopic closure techniques have been introduced for the repair of duodenal wall perforations that occur during endoscopic retrograde cholangiopancreatography ( ercp ) . 
 we report a case of successful repair of a large duodenal wall perforation by using double endoscopic band ligation ( ebl ) and an endoclip . 
 lateral duodenal wall perforation occurred during ercp in a 93-year - old woman with acute calculous cholangitis . 
 we switched to a forward endoscope that had a transparent band apparatus . 
 a 2.0-cm oval - shaped perforation was found at the lateral duodenal wall . 
 we repaired the perforation by sequentially performing double ebl and endoclipping . 
 the first ebl was performed at the proximal edge of the perforation orifice , and two - thirds of the perforation were repaired . 
 the second ebl , which also included the contents covered under the first ebl , repaired the defect almost completely . 
 finally , to account for the possible presence of a residual perforation , an endoclip was applied at the distal end of the perforation . 
 the detection and closure of the perforation were completed within 10 minutes . 
 we suggest that double ebl is an effective method for closure .