You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["RNA", "CellLine", "Protein", "DNA", "CellType"].

Please return the output as a JSON object of the format: {"DNA" : ["TAL1", ...], "RNA": ["mRNAs", ...], "CellLine": ["T cells", ...], "CellType": ["monocytes", ...], "Protein": ["IL-2", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Interleukin-4 inhibits the lipopolysaccharide-induced expression of c-jun and c-fos messenger RNA and activator protein-1 binding activity in human monocytes. We studied the effect of interleukin-4 (IL-4) on the lipopolysaccharide (LPS) induction of two immediate early genes c-fos and c-jun. These genes encode proteins that form the dimeric complex activator protein-1 (AP-1), which is active as a transcriptional factor. Maximal accumulation of either c-fos and c-jun messenger RNA (mRNA) occurred 30 minutes after LPS addition. When cells were treated with IL-4 for 5 hours before LPS activation, both the c-fos and the c-jun mRNA expression was decreased. The inhibition of c-fos and c-jun expression by IL-4 in LPS-treated cells was shown to be due to a lower transcription rate of the c-fos and c-jun genes. IL-4 did not affect the stability of the c-fos and c-jun transcripts. Finally, using electrophoretic mobility shift assays, evidence was obtained that IL-4 inhibits LPS-induced expression of AP-1 protein. These data indicate that IL-4 suppresses the induction of transcription factors in human activated monocytes.
{"CellLine": [], "CellType": ["human activated monocytes", "LPS - treated cells", "monocytes", "human monocytes"], "DNA": ["c - jun", "c - fos and c - jun genes", "c - fos", "c - jun genes"], "Protein": ["IL - 4", "c - fos", "AP - 1 protein", "the dimeric complex activator protein - 1 (AP - 1)", "transcription factors", "interleukin - 4 (IL - 4)", "transcriptional factor", "activator protein - 1", "interleukin - 4", "dimeric complex", "AP - 1", "Interleukin - 4", "c - jun transcripts"], "RNA": ["two immediate early genes c - fos and c - jun", "the c - fos and c - jun genes", "both the c - fos and the c - jun mRNA", "c - fos and c - jun messenger RNA", "c - fos and c - jun", "c - fos and the c - jun", "These genes", "c - jun and c - fos messenger RNA"]}