You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["Outcome", "Participant", "Intervention"].

Please return the output as a JSON object of the format: {"Participant" : ["patients with COPD", ...], "Intervention" : ["Atenolol", ...], "Outcome" : ["blood pressure", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Outpatient management of asthma with regular nebulized beta agonists : comparison of bitolterol mesylate and isoproterenol . Nebulized bitolterol solution and isoproterenol solution were compared when used on a regular basis , 2.5 mg three times a day for 1 month by patients with chronic asthma . In this multicenter , double-blind trial ; 130 nonsteroid-dependent patients were randomized to receive one of the two treatments concomitantly with their regular asthma medications . On study days , at the beginning of the study and after 2 and 4 weeks , treatments were given in the office or laboratory and patients were monitored with pulmonary function tests for eight hours . Both medications induced rapid bronchodilation that had a longer duration after bitolterol . The incidence of tremor was similar with the two medications . Tachycardia and palpitations were more frequent following isoproterenol . Bitolterol has a much longer duration of action and should be considered as a suitable bronchodilator for regular nebulizer treatment of chronic asthma .
{"Intervention": ["bitolterol mesylate", "isoproterenol solution", "isoproterenol", "Nebulized bitolterol solution", "Bitolterol"], "Outcome": ["incidence of tremor", "pulmonary function tests", "Tachycardia and palpitations", "rapid bronchodilation", "duration", "duration of action"], "Participant": ["Outpatient management of asthma", "130", "patients with chronic asthma ."]}