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retrospective review of records was done from hospital database , which included all patients presented to uvea clinic at a tertiary ophthalmic care center between january and december 2012 .
the patients were classified according to current international uveitis study group ( iusg ) classification based on the localization of intraocular inflammation .
various defining descriptors based on clinical onset , duration and course were included based on iusg study .
ocular findings were analyzed in each case by external examination , slit - lamp biomicroscopy , applanation tonometry , and indirect ophthalmoscopy with scleral depression after maximum pupillary dilatation .
total cases seen in this study was 343 ; male ( 209):female ( 134 ) . maximum patients ( 69.6% ) were in the age group of 2029 years . in 2005 , the total cases seen were 308 . in this study ,
anterior uveitis was seen in ( n = 142 ) followed by intermediate uveitis ( n = 81 ) , posterior uveitis ( n = 56 ) , and panuveitis ( n = 64 ) [ table 1 ] . comparison of present study in 2012 with similar study in 2005 in anterior uveitis in 2012 , human leukocyte antigen ( hla ) b27 associated acute anterior uveitis were seen in 58 cases ( 40.84% ) , and idiopathic anterior uveitis was seen in 36 cases ( 25.35% ) . fuchs uveitis syndrome ( fus ) was seen in 19 cases ( 13.38% ) , herpetic anterior uveitis was seen in 15 cases ( 10.56% ) .
comparative data of various etiologies of anterior uveitis in intermediate uveitis in 2012 , idiopathic cases were found to be in 41 cases ( 50.61% ) , tuberculosis ( tb ) related etiology was identified in 17 cases ( 20.98% ) and sarcoid was seen in 19 cases ( 23.24% ) .
comparative data of intermediate uveitis in two studies in posterior uveitis in 2012 , tb - related posterior uveitis was seen in 21 cases ( 37.5% ) , toxoplasma retino - choroiditis was seen in 8 cases ( 14.28% ) and idiopathic choroiditis was found in 7 cases ( 12.50% ) .
comparative data of posterior uveitis in two studies in panuveitis cases in this study showed vogt koyanagi harada s ( vkh ) disease in 10 cases ( 15.62% ) , sympathetic ophthalmia in 14 cases ( 21.87% ) , and tb related panuveitis in 19 cases ( 29.68% ) .
comparison of tb - related uveitis on anatomical classification ( iusg ) is shown in table 6 .
comparative data of panuveitis in two studies comparison of tb related uveitis on the basis of anatomical classification ( iusg )
uveitis is complex intraocular inflammatory disease result from several etiological entities . changing patterns over time
have been reported in studies from the same or different region of the country at different period of time .
when we compared the results of this study with 2005 data , we recognized an increase of hla - b27 associated acute anterior uveitis in 2012 and a sharp decrease in the idiopathic anterior uveitis .
this may be explained by improved diagnostic accuracy as well as hla - b27 estimation in the referral laboratory in our cohort of patients .
herpetic involvement showed increasing trend along with fus in our patients when compared to the 2005 study .
fus was also seen mostly in young patients . in intermediate uveitis , pars planitis , which is idiopathic ,
was seen around 50.61% in 2012 , a drop from the 77.5% in the 2005 data .
this may again be attributed to improved diagnostic accuracy through the newer modalities of investigations , helping in more conclusive inference on the etiology .
tb and sarcoid related intermediate uveitis showed increasing trend in 2012 . in posterior uveitis , infectious uveitis such as tb and toxoplasmosis showed a remarkable trend . while tb cases increased , toxoplasmosis cases decreased in this study . in panuveitis , vkh cases showed a slight decrease trend in 2012 compared to 2005 while there was a sharp increase in sympathetic ophthalmia in 2012 ( 21.87% , n = 14 ) compared to 2005 ( 3.22% , n = 1 ) in all the varieties of uveitis , tb - related uveitis was a significant observation in 2012 as compared to 2005 . the upsurge in intraocular tb in this study in comparison to 2005 was also seen in the studies done by other researcher from india and these trend of increase in infectious uveitis
toxoplasma retinochoroiditis showed an interesting decreasing trend in this study compared to 2005 . in the study of 2005 ,
toxoplasma retinochoroidits was seen in 40.21% and was the most common cause of posterior uveitis and also overall , the most common reason of infectious uveitis . in this study ,
the differential diagnosis of uveitis has changed with time . in european countries , tb and syphilis
were regarded as the main cause of uveitis in the first half of 20 century .
thereafter , a decrease of tb and syphilis as a cause of uveitis was reported in studies from europe in general and finland in particular during mid-1970 s .
again , in india , the resurgence of tb and other infectious uveitis such as parasitic uveitis was seen in the recent study by rathinam and namperumalsamy in the south indian population .
what was true in rathinam and namperumalsamy study was also true in the study by biswas et al . and singh et al .
from different zones of india where infectious uveitis was seen around 30% of all uveitis . in this study , there were two isolated index cases of anterior chamber live parasites causing anterior uveitis , and they were diagnosed as dirofilaria and thelazia , respectively .
we , thus , described the causes in both the studies in a same population of the country .
this can lead the investigators in the right direction to know the current scenario of hospital - based uveitis cases in the northeast indian population and direct means to improve the health condition in the suffering people .
uveitis incorporates innumerable conditions , all of which are characterized by inflammation of the uveal tract . 
 study of etiological factors in uveitis in the population often give important disease - specific indications and changing pattern in subsequent studies are important to know further newer occurrences of various disease prevalence . 
 awareness of regional variation in disease configuration is essential to develop a region specific list of differential diagnoses and also for comparison with different sub - population of the country and the world . 
 we report the changing pattern of uveitis in a tertiary institute in the northeast india and found that tubercular uveitis had increased in hospital - based study .