You will be presented with a collection of medical randomized controlled trial (RCT) reports addressing a shared clinical question -- for instance, the efficacy of a medical intervention on a disease or condition. Given the titles and abstracts of these reports, your task is to generate the conclusion of the systematic review article synthesizing the key findings. Your conclusion should be a few sentences long. In your response, include only the conclusion and no other text. The RCT reports are below.



Title 1:
Improvement in glucose tolerance due to Momordica charantia (karela).
Abstract 1:
The effect of karela ( Momordica charantia ) , a fruit indigenous to South America and Asia , on glucose and insulin concentrations was studied in nine non-insulin-dependent diabetics and six non-diabetic laboratory rats . A water-soluble extract of the fruits significantly reduced blood glucose concentrations during a 50 g oral glucose tolerance test in the diabetics and after force-feeding in the rats . Fried karela fruits consumed as a daily supplement to the diet produced a small but significant improvement in glucose tolerance . Improvement in glucose tolerance was not associated with an increase in serum insulin responses . These results show that karela improves glucose tolerance in diabetes . Doctors supervising Asian diabetics should be aware of the fruit 's hypoglycaemic properties


Title 2:
Phytochemical determination and extraction of Momordica charantia fruit and its hypoglycemic potentiation of oral hypoglycemic drugs in diabetes mellitus (NIDDM).
Abstract 2:
Momordica charantia ( MC ) fruit was subjected to phytochemical and pharmacological interaction studies with oral hypoglycemis in NIDDM patients . Phytochemical , chromatographical analysis and extraction of methanolic MC fruit soft ( semi-solid form ) in CCl4 + C6H6 solvent system yielded 15 diverse chemical constituents -- alkaloids , glycosides , aglycone , tannin , sterol , phenol and protein . The CCl4 + C6H6 MC soft extract was used orally in a dose of 200 mg twice daily ( BD ) for pharmacological interactions with two diversely acting oral hypoglycemic agents--1 ) metformin BD and 2 ) glibenclamide BD in 15 patients of either sex ( 52 - 65 years of age ) of NIDDM . It was observed that with CCl4 + C6H6 MC soft extract plus half doses of metformin or glibenclamide or both in combination caused hypoglycemia greater than that caused by full doses used in the study with 7 days treatment . Conclusively the extract acts in synergism with oral hypoglycemics and potentiates their hypoglycemia in NIDDM


Title 3:
Effect of Momordica charantia (Karolla) extracts on fasting and postprandial serum glucose levels in NIDDM patients.
Abstract 3:
Effect of Momordica charantia , a bitter vegetable popularly known as Karolla , on fasting and post pr and ial ( 2 hours after 75 gm oral glucose intake ) serum glucose levels were studied in 100 cases of moderate non-insulin dependent diabetic subjects . Drinking of the aqueous homogenized suspension of the vegetable pulp led to significant reduction ( p < 0.001 ) of both fasting and post-pr and ial serum glucose levels . This hypoglycaemic action was observed in 86 ( 86 % ) cases . Five cases ( 5 % ) showed lowering of fasting serum glucose only
There were no documentations of death from any cause , morbidity , ( health-related ) quality of life and costs .
AUTHORS ' CONCLUSIONS There is insufficient evidence to recommend momordica charantia for type 2 diabetes mellitus .