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deceased donors ( dds ) with the brain death due to head injury are the major source of organs for transplantation .
recent studies mention incidence of post - head injury disseminated intravascular coagulation ( dic ) ranging from 24% to 50% .
many centers hesitate in accepting organs from donors with dic due to increased risk of primary graft non - function and/or high chances of morbidity / mortality . in india , about 61% of stage v chronic kidney disease ( ckd ) patients are not on any form of renal replacement therapy and only 2% are prepared for renal transplantation .
there is a wide gap between the demand and supply of organs for patients with end organ failure and potential chances of getting a deceased donor ( dd ) organ in the present scenario are dismal . to reduce this disparity ,
an additional approach that could be considered is accepting dd with head injury with disseminated intravascular coagulation ( dic ) for organ donation since , dd with traumatic head injury are the most common source of dd organ transplantation .
whether to consider a dd with dic is controversial since some studies have shown increased incidence of primary non - function in transplanted kidneys while others have shown good long - term outcome , but initial delayed graft function .
we present two successful renal transplants ( rtx ) from a brain - dead dd with head injury with extensive dic and deranged renal function .
a 19-year - old male patient with head injury following a road traffic accident was brought in emergency to a private trauma care hospital . on admission
, he was found to be comatose , had fractured right tibia and left femur . on day of admission , his renal function and liver function tests were normal with serum creatinine ( scr ) , 1.40 mg / dl .
however , he had deranged coagulation profile with activated partial thromboplastin time : 32.7 s , ( control : 27.9 s ) , prothrombin time : 20 s ( control : 10.6 s ) and international normalized ratio was 1.89 .
his hemoglobin was 7.21 g / dl , total leukocyte count 1.52  10/l and platelet count was 2.08  10/ l . he had hypotension and fall in hemoglobin level ; hence , he was transfused 4 units of whole blood and started on vasopressors dopamine at 10 g / kg / min and noradrenaline at 10 g/ min .
blood pressure was maintained around 110 - 120 systolic and 80 - 90 mm of hg diastolic . on 2 day
, he developed extensive petechiae and purpura all over the body and oozing of blood through wounds hence 6 units of fresh frozen plasma were transfused .
however , he further deteriorated with increase in purpuric spots , further derangement in coagulation profile , decreasing platelet count and hemoglobin level , low serum fibrinogen level and d - dimer > 4000 ng / ml suggestive of extensive dic .
patient was declared brain - dead by neurophysician and neurosurgeon at the interval of 6 h. ultrasonography of the abdomen showed normal sized kidneys .
the relatives were explained about organ donation . since , they agreed he was shifted to our institute .
his renal function was deranged with scr , 3.57 mg / dl and blood urea 92 mg / dl .
his hemoglobin had dropped to 7.3 g/ dl and platelet count was 5.5  10/l .
both kidneys were harvested and transplanted in two recipients with favorable complement - dependent lymphocytotoxicity cross - match .
laboratory parameters of donor recipient 1-was a 25-year - old male on maintenance hemodialysis for , 55 months .
he received induction therapy with rabbit anti - thymocyte globulin ( r - atg ) 1.5 mg / kg and 3 doses of methyl prednisolone 500 mg/ day .
his hematological , coagulation and renal function profile remained within normal range throughout the post - operative period and follow - up period of 1 month .
scr normalized on 5 post - operative day to 1.22 mg/ dl and he was discharged on 7 post - operative day with scr , 1.18 mg / dl on maintenance immunosuppression of tacrolimus 0.08 mg / day , mycophenolate sodium 720 mg twice daily and prednisolone , 20 mg / day . there was no evidence of graft dysfunction throughout the follow - up period of 1 month .
she received the same induction and maintenance immunosuppression therapy as recipient 1 . on first post - operative day
however , it recovered gradually and normalized on 4 post - operative day without any treatment .
coagulation profile performed performed on 1 and 4 post - operative day was normal and there was no evidence of bleeding diathesis .
she was discharged on 12 post - operative day with scr of 0.87 mg / dl with same maintenance immunosuppression as that of recipient 1 . demographic profile and laboratory parameters of both recipients
tacrolimus level of both transplant recipients in immediate post - transplant period and throughout the follow - up period of 1 month was maintained in the range of 7 - 10 ng / ml .
dic is common in dd with head injury with incidence of 59% in open head trauma , 43% in combined open and closed head trauma and 37% in closed head trauma .
mechanisms responsible for dic are activation of the coagulation cascade through release of brain tissue thromboplastin , inflammatory cytokines , tissue factor activation and exposure of phospholipids to circulating blood .
dic causes occlusion of small and medium sized vessels due to the formation of fibrin thrombi . many centers still hesitate to accept organs from dd with dic due to reported incidence of primary non - function . in one study
, fibrin thrombi present in renal biopsy at 1 h post - transplant was not present in biopsy done at 7 days and 6months post - transplant .
recipients of grafts with donor thrombi were more likely to exhibit delayed graft function ; however , graft function and survival at 1 and 2 years post - transplant was good suggesting that the presence of donor microvascular thrombosis does nt nt portend poor outcome in rtx .
some studies suggest that the presence of good renal function and renal biopsy is necessary prior to transplantation to exclude renal cortical necrosis due to microvascular thrombosis in dic , but other reports negate this view .
pre - transplant renal biopsy is not a good method to guide organ allocation in cases of donor dic because of false positive and false negative results and also inability of renal biopsy to predict reversibility of fibrin thrombi by glomerular fibrinolytic system after transplantation .
one study reported increased incidence of post - transplant thrombocytopenia in recipients of kidney from dic positive donors .
it also noted that there was increased incidence of delayed graft function in recipients who had post - transplant thrombocytopenia , but long - term graft survival was good .
recipient thrombocytopenia may be an early sign of intrarenal clotting due to dic ; thus , may contribute to delayed graft function or slow graft function .
there are some case reports , which showed that even presence of severe dic with thrombotic microangiopathy on renal biopsy and renal function impairment in dd is not a reason for excluding organ from dic positive donor .
we selected this donor for organ donation because of his young age and since , there was no any major illness in the past ; also he had good urine output prior to transplant .
one of our recipients developed transient thrombocytopenia , but there was no clinical or laboratory evidence of dic and also there was no evidence of delayed graft function or slow graft functions in either recipient .
to conclude , a carefully selected dd with head injury and dic even with deranged renal function may not be a contraindication for organ donation if other risk factors for primary non - function are excluded .
deceased donors ( dds ) with the brain death due to head injury are the major source of organs for transplantation . 
 the incidence of post - head injury disseminated intravascular coagulation ( dic ) ranges from 24% to 50% . 
 many centers do not accept organs from donors with dic due to increased risk of primary graft non - function and/or high chances of morbidity / mortality . 
 we performed two successful renal transplants from a dd with head injury with dic and deranged renal function . 
 one of the recipients developed transient thrombocytopenia , but there was no evidence of dic or delayed graft functions in either of the recipients . over a follow - up of 1 month , both are doing well with stable graft function and hematological profile . 
 thus , a carefully selected dd with severe dic even with deranged renal function is not a contraindication for organ donation if other risk factors for primary non - function are excluded . 
 this approach will also help in overcoming organ shortage .