Given an abstract from a research paper, your task is to identify and label relationships between chemical compounds and genes mentioned in the abstract.

The relationship type must be one of ['DOWNREGULATOR', 'SUBSTRATE', 'INDIRECT-REGULATOR', 'PART-OF', 'MODULATOR-ACTIVATOR', 'REGULATOR', 'INHIBITOR', 'COFACTOR', 'UPREGULATOR', 'ACTIVATOR', 'ANTAGONIST', 'NOT', 'INDIRECT-DOWNREGULATOR', 'SUBSTRATE_PRODUCT-OF', 'INDIRECT-UPREGULATOR', 'AGONIST', 'PRODUCT-OF', 'MODULATOR', 'DIRECT-REGULATOR', 'UNDEFINED', 'AGONIST-INHIBITOR', 'AGONIST-ACTIVATOR', 'MODULATOR-INHIBITOR'].

Please format your output as a JSON array. Each entry in the array should express a single relation, formatted as ["<Entity_A>", "<RELATION_A_B>", "<Entity_B>"]. If no relations can be found, please output an empty JSON array [].

Abstract:

Trace amine-associated receptor 1 displays species-dependent stereoselectivity for isomers of methamphetamine, amphetamine, and para-hydroxyamphetamine. The synthetic amines methamphetamine (METH), amphetamine (AMPH), and their metabolite para-hydroxyamphetamine (POHA) are chemically and structurally related to the catecholamine neurotransmitters and a small group of endogenous biogenic amines collectively referred to as the trace amines (TAs). Recently, it was reported that METH, AMPH, POHA, and the TAs para-tyramine (TYR) and beta-phenylethylamine (PEA) stimulate cAMP production in human embryonic kidney (HEK) -293 cells expressing rat trace amine-associated receptor 1 (rTAAR1). The discovery that METH and AMPH activate the rTAAR1 motivated us to study the effect of these drugs on the mouse TAAR1 (mTAAR1) and a human-rat chimera (hrChTAAR1). Furthermore, because S- (+) -isomers of METH and AMPH are reported to be more potent and efficacious in vivo than R- (-), we determined the enantiomeric selectivity of all three species of TAAR1. In response to METH, AMPH, or POHA exposure, the accumulation of cAMP by HEK-293 cells stably expressing different species of TAAR1 was concentration- and isomer-dependent. EC50 values for S- (+) -METH were 0.89, 0.92, and 4.44 microM for rTAAR1, mTAAR1, and h-rChTAAR1, respectively. PEA was a potent and full agonist at each species of TAAR1, whereas TYR was a full agonist for the rodent TAAR1s but was a partial agonist at h-rChTAAR1. Interestingly, both isomers of METH were full agonists at mTAAR1 and h-rChTAAR1, whereas both were partial agonists at rTAAR1. Taken together, these in vitro results suggest that, in vivo, TAAR1 could be a novel mediator of the effects of these drugs.
[["POHA", "REGULATOR", "rat trace amine-associated receptor 1"], ["PEA", "REGULATOR", "rat trace amine-associated receptor 1"], ["TYR", "AGONIST", "h-rChTAAR1"], ["METH", "ACTIVATOR", "TAAR1"], ["AMPH", "REGULATOR", "rTAAR1"], ["POHA", "REGULATOR", "TAAR1"], ["para-tyramine", "REGULATOR", "rat trace amine-associated receptor 1"], ["S- (+) -METH", "ACTIVATOR", "rTAAR1"], ["methamphetamine", "REGULATOR", "Trace amine-associated receptor 1"], ["PEA", "AGONIST-ACTIVATOR", "TAAR1"], ["S- (+) -METH", "ACTIVATOR", "h-rChTAAR1"], ["para-hydroxyamphetamine", "REGULATOR", "Trace amine-associated receptor 1"], ["METH", "AGONIST", "rTAAR1"], ["AMPH", "REGULATOR", "rat trace amine-associated receptor 1"], ["METH", "ACTIVATOR", "rTAAR1"], ["TYR", "REGULATOR", "rat trace amine-associated receptor 1"], ["TYR", "AGONIST-ACTIVATOR", "rodent TAAR1s"], ["AMPH", "ACTIVATOR", "rTAAR1"], ["amphetamine", "REGULATOR", "Trace amine-associated receptor 1"], ["METH", "AGONIST-ACTIVATOR", "h-rChTAAR1"], ["beta-phenylethylamine", "REGULATOR", "rTAAR1"], ["METH", "AGONIST-ACTIVATOR", "mTAAR1"], ["beta-phenylethylamine", "REGULATOR", "rat trace amine-associated receptor 1"], ["para-tyramine", "REGULATOR", "rTAAR1"], ["POHA", "REGULATOR", "rTAAR1"], ["PEA", "REGULATOR", "rTAAR1"], ["S- (+) -METH", "ACTIVATOR", "mTAAR1"], ["TYR", "REGULATOR", "rTAAR1"], ["AMPH", "ACTIVATOR", "TAAR1"], ["METH", "REGULATOR", "rTAAR1"], ["METH", "REGULATOR", "rat trace amine-associated receptor 1"], ["AMPH", "REGULATOR", "TAAR1"], ["METH", "REGULATOR", "TAAR1"]]