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Paper text:
as the most common form of dementia , alzheimer disease is characterized by progressive loss of memory and deterioration of cognitive functions . it is predicted that about 75.63 million people would suffer from dementia by 2030 .
accordingly , in the present study , the intended remedy was selected and an appropriate pharmacognostical and pharmaceutical evaluations were performed .
by searching through the traditional pharmaceutical manuscripts such as qarabadeen - e - salehi , qarabadeen - e - azam , qarabadeen - e - ghaderi and canon of medicine , a simple but proven compound remedy ( frankincense and black pepper ) was selected .
related pharmaceutical assessments such as weight variation , hardness , friability , and disintegration tests as well as pharmacognostical evaluations such as microscopic characterization , tlc , gc / ms , ft / ir fingerprints , and radical scavenging activity assessment ( dpph ) were performed .
the resulting formulation , as a floating tablet , included 60% of frankincense gum and 15% of black pepper along with appropriate pharmaceutical ingredients ( weight variation : 0.2190.004 g , hardness : 6.500.67 , friability : 0.45% , disintegration time > 30 min ) .
microscopic characterization demonstrated stone cells , calcium oxalate crystals , sclereids of endocarp and pitted cells of mesocarp of pepper fruits as well as oil drops of frankincense gum .
gc / ms analysis revealed acetyl acetate and trans - caryophyllene as the main constituent . moderate radical scavenging activity (
ic50 > 100 g / ml ) was calculated for the methanol extract of tablets .
carrying out and validating a gc method for standardization of the formulated tablet , and having the structure for the effectiveness of these medicinal herbs in alzheimer may be the horizon for a new alzheimer - targeted medicine .
background : as the most common form of dementia , alzheimer disease is characterized by progressive loss of memory and deterioration of cognitive functions . 
 it is predicted that about 75.63 million people would suffer from dementia by 2030 . 
 apart from conventional remedies , the application of herbal medicines is on the rise . 
 there are numerous natural medicaments reported in the traditional manuscript of persian medicine . 
 accordingly , in the present study , the intended remedy was selected and an appropriate pharmacognostical and pharmaceutical evaluations were performed.methods:by searching through the traditional pharmaceutical manuscripts such as qarabadeen - e - salehi , qarabadeen - e - azam , qarabadeen - e - ghaderi and canon of medicine , a simple but proven compound remedy ( frankincense and black pepper ) was selected . 
 a floating tablet was designed and formulated from those herbal components . 
 related pharmaceutical assessments such as weight variation , hardness , friability , and disintegration tests as well as pharmacognostical evaluations such as microscopic characterization , tlc , gc / ms , ft / ir fingerprints , and radical scavenging activity assessment ( dpph ) were performed.results:the resulting formulation , as a floating tablet , included 60% of frankincense gum and 15% of black pepper along with appropriate pharmaceutical ingredients ( weight variation : 0.2190.004 g , hardness : 6.500.67 , friability : 0.45% , disintegration time > 30 min ) . 
 microscopic characterization demonstrated stone cells , calcium oxalate crystals , sclereids of endocarp and pitted cells of mesocarp of pepper fruits as well as oil drops of frankincense gum . 
 tlc fingerprinting showed classes of secondary metabolites related to both components . 
 gc / ms analysis revealed acetyl acetate and trans - caryophyllene as the main constituent . 
 moderate radical scavenging activity ( ic50 > 100 g / ml ) was calculated for the methanol extract of tablets.conclusion:carrying out and validating a gc method for standardization of the formulated tablet , and having the structure for the effectiveness of these medicinal herbs in alzheimer may be the horizon for a new alzheimer - targeted medicine .