You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["RNA", "CellLine", "Protein", "DNA", "CellType"].

Please return the output as a JSON object of the format: {"DNA" : ["TAL1", ...], "RNA": ["mRNAs", ...], "CellLine": ["T cells", ...], "CellType": ["monocytes", ...], "Protein": ["IL-2", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

The lymphotoxin promoter is stimulated by HTLV-I tax activation of NF-kappa B in human T-cell lines. The HTLV-I transcriptional activator tax was used to gain insight into the mechanism of lymphotoxin (LT; TNF-beta) gene induction. Tax-expressing cell lines produce LT biologic activity. An LT promoter (LT-293) CAT construct that contained an NF-kappa B site was active in the LT-producing C81-66-45 cell line, which contains defective HTLV-I but expresses tax. The observation that a mutated LT-kappa B construct (M1-CAT) was inactive in C81-66-45, confirmed the importance of NF-kappa B in LT gene expression. Tax was transfected into HTLV-I-negative human T-cell lines. Jurkat T cells stably expressing tax contained elevated levels of NF-kappa B that directly bound to the LT-kappa B site. Tax co-transfected with reporter constructs into Jurkat cells maximally activated HTLV-I-LTR-CAT and kappa B-fos-CAT and also activated LT-293 to a lesser extent. In JM T cells, tax induced LT-293 activity by two-to four-fold, though there was no induction of M1-CAT. The increase in LT-293 CAT activity mirrored the increase in LT biologic activity seen under these conditions. These studies, the first to demonstrate induction of LT promoter activity over basal levels, indicate that HTLV-I tax causes low-level activation of both endogenous LT and the LT promoter, at least in part through activation of NF-kappa B.
{"CellLine": ["C81 - 66 - 45", "Tax - expressing cell lines", "Jurkat T cells", "LT - producing C81 - 66 - 45 cell line", "Jurkat cells", "human T - cell lines", "HTLV - I - negative human T - cell lines", "JM T cells"], "CellType": [], "DNA": ["mutated LT - kappa B construct", "LT - 293", "lymphotoxin (LT ; TNF - beta) gene", "reporter constructs", "M1 - CAT", "LT promoter", "lymphotoxin promoter", "NF - kappa B site", "LT promoter (LT - 293) CAT construct", "LT - kappa B site"], "Protein": ["LT", "HTLV - I - LTR - CAT", "lymphotoxin", "HTLV - I transcriptional activator tax", "M1 - CAT", "CAT", "TNF - beta", "Tax", "NF - kappa B", "tax", "HTLV - I tax", "kappa B - fos - CAT"], "RNA": []}