You will be shown the abstract of a medical clinical trial report. Your task is to extract all the findings from this report into a JSON array. Each finding should contain the following five elements:

- Intervention: The medical intervention being tested. This should be a text span copied from the input passage.
- Comparator: The baseline against which the intervention is being evaluated. This should be a text span copied from the input passage. If no comparator is reported, set to `null`.
- Outcome: The medical outcome whose effect is being measured. This should be a text span copied from the input passage.
- Effect: The effect of the intervention on the outcome, relative to the comparator. The effect should be one of the following three values: ("significantly increased", "significantly decreased", "no significant difference").
- Evidence: The evidence for the effect. This should be a text span copied from the input passage.

Please format your output as a JSON array. Each entry in the output should be an array containing the 5 elements listed above, in the following order: [<intervention>, <comparator>, <outcome>, <effect>, <evidence>].

For example, an output with two findings might read:
```
[["aspirin", "placebo", "headache severity", "significantly decreased", "Mean headache severity was significantly decreased in the aspirin group compared to the placebo group (p < 0.05)."], ["aspirin", "placebo", "weight loss", "no significant difference", "We did not observe any difference in weight loss between the group given aspirin relative to the control group"]]
```

There are 6 finding(s) in the abstract below. Please extract them. Output only the JSON array with these 6 findings. Do not include any additional text.

Abstract:
ABSTRACT.OBJECTIVE: Statins treatment may modify the levels of zinc and selenium, minerals that can improve vascular function and reduce oxidative damage and inflammation in atherosclerotic patients. This study aimed to evaluate the effects of rosuvastatin, alone or associated with zinc and selenium supplementation, on lipid profile, antioxidant enzymes and mineral status in coronary artery disease patients.

ABSTRACT.MATERIAL AND METHODS: A double-blind randomized clinical trial was performed in which patients (n = 76) were treated with 10 mg rosuvastatin over 4 months associated or not with zinc (30 mg/d) and selenium (150 μg/d) supplementation. The following parameters were analyzed before and after the intervention: anthropometric measurements, lipid profile, high sensitivity C-reactive protein (hs-CRP), electronegative low density lipoprotein (LDL(-)) concentrations, activities of glutathione peroxidase (GPx), superoxide dismutase (SOD), zinc and selenium concentrations in blood plasma and erythocytes. Significance was determined using an α of 5% (two-tailed).

ABSTRACT.RESULTS: We found that rosuvastatin therapy was efficient in reducing total cholesterol, LDL-cholesterol, non-HDL cholesterol, triglycerides, and hs-CRP independently of mineral supplementation. Neither treatment was associated with significant changes in LDL(-). Similarly, the antioxidant enzymes GPx and SOD activity were unchanged by treatments. Neither treatment was associated with significant differences in concentrations of zinc or selenium in blood plasma and erythocytes of studied groups.

ABSTRACT.CONCLUSION: Rosuvastatin treatment did not affect zinc and selenium levels in coronary artery disease patients. The zinc and selenium supplementation at doses used in this study did not change lipid profile or SOD and GPx activity in patients receiving rosuvastatin. Further studies should be focused on testing alternative doses and supplements in different populations to contribute for a consensus on the ideal choice of antioxidants to be used as possible complementary therapies in atherosclerotic patients.

ABSTRACT.TRIAL REGISTRATION: ClinicalTrials.gov NCT01547377


Findings:
[["10 mg rosuvastatin over 4 months with zinc (30 mg/d) and selenium (150 I\u03021\u20444g/d) supplementation.", "10 mg rosuvastatin over 4 months", "glutathione peroxidase (GPx) and superoxide dismutase (SOD) levels", "no significant difference", "Similarly, the activities of the antioxidant enzymes GPx and SOD were unchanged by treatments (P \u003e 0.42) and were similar in both groups (P \u003e 0.33)."], ["10 mg rosuvastatin over 4 months with zinc (30 mg/d) and selenium (150 I\u03021\u20444g/d) supplementation.", "10 mg rosuvastatin over 4 months", "glutathione peroxidase (GPx) and superoxide dismutase (SOD) levels", "no significant difference", "Similarly, the antioxidant enzymes GPx and SOD activity were unchanged by treatments."], ["10 mg rosuvastatin over 4 months with zinc (30 mg/d) and selenium (150 I\u03021\u20444g/d) supplementation.", "10 mg rosuvastatin over 4 months", "total cholesterol, LDL-c, and non-HDL-c levels", "no significant difference", "Significant decreases in total cholesterol, LDL-c, and non-HDL-c levels were observed for all patients, regardless of group; however, there were no differences between the rosuvastatin + mineral-supplemented and rosuvastatin + placebo groups (P \u003e 0.21)."], ["10 mg rosuvastatin over 4 months with zinc (30 mg/d) and selenium (150 I\u03021\u20444g/d) supplementation.", "10 mg rosuvastatin over 4 months", "Triglycerides concentrations", "no significant difference", "Triglycerides concentrations dropped noticeably in both groups, though this pattern was significant only for the placebo group (P = 0.034); despite this, differences between the two groups were not significant (P = 0.76)."], ["10 mg rosuvastatin over 4 months with zinc (30 mg/d) supplementation.", "10 mg rosuvastatin over 4 months with selenium (150 I\u03021\u20444g/d) supplementation.", "concentrations of zinc and selenium of studied groups.", "no significant difference", "Neither treatment was associated with significant differences in concentrations of zinc (plasma: P \u003e 0.14; erythrocyte: P \u003e 0.14) or selenium (plasma: P \u003e 0.63; erythrocyte: P \u003e 0.07) of studied groups."], ["10 mg rosuvastatin over 4 months with zinc (30 mg/d) supplementation.", "10 mg rosuvastatin over 4 months with selenium (150 I\u03021\u20444g/d) supplementation.", "concentrations of zinc and selenium of studied groups.", "no significant difference", "Neither treatment was associated with significant differences in concentrations of zinc or selenium in blood plasma and erythocytes of studied groups."]]