You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["Outcome", "Participant", "Intervention"].

Please return the output as a JSON object of the format: {"Participant" : ["patients with COPD", ...], "Intervention" : ["Atenolol", ...], "Outcome" : ["blood pressure", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Lack of effect of food on the steady state pharmacokinetics of BMS-181101 , an antidepressant , in healthy subjects . The effect of food on the pharmacokinetics of BMS-181101 , a new anti-depressant under development , was investigated in 12 healthy male volunteers at steady state . Each subject received a 15 mg oral dose of BMS-181101 twice a day ( q 12 h ) for 11 days and a morning dose of BMS-181101 on day 12 . Six subjects were randomly assigned to receive BMS-181101 under fasted conditions from days 1 to 6 and then crossed over to fed conditions from days 7 to 12 . The other six subjects received the reverse conditions , fed for days 1-6 and fasted for days 7-12 . Serial blood samples were collected up to 12 h on days 6 and 12 following the administration of the morning dose . In addition , trough blood samples were collected on days 4 , 5 , 10 , and 11 prior to the morning dose . Plasma samples were analyzed for intact BMS-181101 using a validated high-performance liquid chromatography method with an electrochemical detector . BMS-181101 was well tolerated both with and without ingestion of food . The statistical evaluation of the Cmin values indicated that steady state of BMS-181101 was achieved by the fourth day of dosing regardless of whether the subject was fasted or fed . When BMS-181101 was administered with food , Cmax was reduced by about 25 % and tmax was prolonged by 1 h. However , AUCtau , t1/2 , and time to attain steady state of BMS-181101 were not altered by ingestion of food . In summary , BMS-181101 can be given with food without adversely impacting the safety or pharmacokinetic profiles of the drug .
{"Intervention": ["BMS-181101", "food"], "Outcome": ["AUCtau", "effect of food on the pharmacokinetics of BMS-181101", "of BMS-181101", "Cmin values", "t1/2", "tolerated", "intact BMS-181101", "was reduced", "Plasma samples", "was prolonged", "trough blood samples", ", and", "safety", "steady state pharmacokinetics of BMS-181101", "Cmax", "time to attain steady state", "pharmacokinetic profiles", "steady state", "Serial blood samples", "tmax", ","], "Participant": ["Six", "male", "12", "healthy"]}