You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["RNA", "CellLine", "Protein", "DNA", "CellType"].

Please return the output as a JSON object of the format: {"DNA" : ["TAL1", ...], "RNA": ["mRNAs", ...], "CellLine": ["T cells", ...], "CellType": ["monocytes", ...], "Protein": ["IL-2", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Human immunodeficiency virus type 1 Nef protein inhibits NF-kappa B induction in human T cells. Human immunodeficiency virus type 1 (HIV-1) can establish a persistent and latent infection in CD4 + T lymphocytes (W. C. Greene, N. Engl. J. Med. 324: 308-317, 1991; S. M. Schnittman, M. C. Psallidopoulos, H. C. Lane, L. Thompson, M. Baseler, F. Massari, C. H. Fox, N. P. Salzman, and A. S. Fauci, Science 245: 305-308, 1989). Production of HIV-1 from latently infected cells requires host cell activation by T-cell mitogens (T. Folks, D. M. Powell, M. M. Lightfoote, S. Benn, M. A. Martin, and A. S. Fauci, Science 231: 600-602, 1986; D. Zagury, J. Bernard, R. Leonard, R. Cheynier, M. Feldman, P. S. Sarin, and R. C. Gallo, Science 231: 850-853, 1986). This activation is mediated by the host transcription factor NF-kappa B [ G. Nabel and D. Baltimore, Nature (London) 326: 711-717, 1987 ]. We report here that the HIV-1-encoded Nef protein inhibits the induction of NF-kappa B DNA-binding activity by T-cell mitogens. However, Nef does not affect the DNA-binding activity of other transcription factors implicated in HIV-1 regulation, including SP-1, USF, URS, and NF-AT. Additionally, Nef inhibits the induction of HIV-1-and interleukin 2-directed gene expression, and the effect on HIV-1 transcription depends on an intact NF-kappa B-binding site. These results indicate that defective recruitment of NF-kappa B may underlie Nef 's negative transcriptional effects on the HIV-1 and interleukin 2 promoters. Further evidence suggests that Nef inhibits NF-kappa B induction by interfering with a signal derived from the T-cell receptor complex.
{"CellLine": [], "CellType": ["CD4 + T lymphocytes", "human T cells"], "DNA": ["HIV - 1 and interleukin 2 promoters", "NF - kappa B - binding site"], "Protein": ["Human immunodeficiency virus type 1 Nef protein", "T - cell receptor complex", "NF - AT", "T -  cell", "HIV - 1", "Nef", "T - cell mitogens", "HIV - 1 - encoded Nef protein", "USF", "URS", "NF - kappa B", "SP - 1", "host transcription factor", "Human immunodeficiency virus type 1 (HIV - 1)", "transcription factors"], "RNA": []}