You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["Chemical"].

Please return the output as a JSON object of the format: {"Chemical": ["Arsenic", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Strong Parent-of-Origin Effects in the Association of KCNQ1 Variants with Type 2 Diabetes Mellitus in American Indians. Parent-of-origin effects were observed in an Icelandic population for several genetic variants associated with type 2 diabetes, including those in KLF14 (rs4731702), MOB2 (rs2334499) and KCNQ1 (rs2237892, rs231362). We analyzed parent-of-origin effects for these variants, along with two others in KCNQ1 identified in previous genome-wide association studies (rs2237895, rs2299620), in 7351 Pima Indians from 4549 nuclear families; 34% of participants had diabetes. In a subset of 287 normoglycemic individuals, acute insulin secretion was measured by an intravenous glucose tolerance test. Statistically significant (P<0.05) parent-of-origin effects were seen for association with type 2 diabetes for all variants. The strongest effect was seen at rs2299620 in KCNQ1: the C allele was associated with increased diabetes when maternally-derived (odds ratio=1.92, P=4.1x10(-12)), but not when paternally-derived (odds ratio=0.93, P=0.47; P=9.9x10(-6) for difference in maternal and paternal effects). A maternally-derived C allele was also associated with a 28% decrease in insulin secretion (P=0.002). This study confirms parent-of-origin effects in the association with type 2 diabetes for variants in KLF14, MOB2 and KCNQ1. In Pima Indians the effect of maternally-derived KCNQ1 variants appears to be mediated through decreased insulin secretion, and is particularly strong, accounting for 4% of the variance in liability to diabetes.
{"Chemical": ["glucose"]}