You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["RNA", "CellLine", "Protein", "DNA", "CellType"].

Please return the output as a JSON object of the format: {"DNA" : ["TAL1", ...], "RNA": ["mRNAs", ...], "CellLine": ["T cells", ...], "CellType": ["monocytes", ...], "Protein": ["IL-2", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Expression levels of the thyrotropin receptor gene in autoimmune thyroid disease: coregulation with parameters of thyroid function and inverse relation to major histocompatibility complex classes I and II. Using a human TSH receptor (TSH-R) cDNA probe, we investigated TSH-R transcript levels in 13 human thyroid fragments by Northern blot analysis; 7 Graves 'disease, 2 Hashimoto's disease, 3 endemic goiter, and 1 healthy thyroid gland were studied. TSH-R expression levels were variable, but displayed a close correlation to the expression of thyroid peroxidase (r = 0. 703; P < 0. 05), thyroglobulin (r = 0. 817; P < 0. 01), and the nuclear oncogene c-fos (r = 0. 935; P < 0. 001), but not c-myc. Overall, TSH-R transcript levels were low or absent in those thyroids in which expression of the major histocompatibility complex class I or II (MHC I or II) was high, thus establishing an inverse relation (MHC I, r =-0. 791; P < 0. 01; MHC II, r =-0. 784; P < 0. 01). In situ hybridization showed that apart from lymphocytes, thyroid cells themselves were the source of MHC II transcripts. gamma-Interferon expression was only detectable in 1 Hashimoto 's goiter. Our findings suggest that next to lymphocyte infiltration, active regulatory events in the thyrocyte are responsible for the inverse relation between functional parameters (TSH-R, thyroid peroxidase, thyroglobulin, and c-fos) and immunological markers (MHC I and II).
{"CellLine": [], "CellType": ["thyrocyte", "lymphocytes", "thyroid cells"], "DNA": ["nuclear oncogene c - fos", "thyrotropin receptor gene", "human TSH receptor (TSH - R) cDNA probe"], "Protein": ["major histocompatibility complex class I or II", "gamma - Interferon", "major histocompatibility complex classes I and II", "c - myc", "the major histocompatibility complex class I or II (MHC I or II)", "human TSH receptor", "TSH - R", "MHC II transcripts", "immunological markers (MHC I and II)", "thyroid peroxidase", "MHC I or II", "MHC I and II", "MHC I", "thyroglobulin", "MHC II"], "RNA": []}