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the application of fibrinolytic therapy in acute myocardial infarction is generally practiced to reduce the associated morbidities ; however , there are rare reports of pulmonary hemorrhage attributed to the use of fibrinolytic therapy throughout the literature . in this case report
, we present a 45-year - old man who developed pulmonary hemorrhage after administration of streptokinase for the treatment of acute myocardial infarction .
a 45-year - old male with no history of ischemic heart disease presented to the emergency department 45 min after the onset of retro - sternal chest pain which radiated to the left arm and accompanied with cold sweating .
his past medical history was only indicative of cocaine and tobacco abuse for several years .
initial physical examination demonstrated a blood pressure of 145/90 mmhg , heart rate of 94/min , respiratory rate of 18/min , oral temperature of 37.4c and oxygen saturation 95% while he was breathing ambient air .
the electrocardiography revealed sinus rhythm and elevated st segment in v1-v4 leads and depressed st segment in ii , iii , avf , v5 and v6 leads , well - suited with the diagnosis of acute antroseptal myocardial infarction .
the patient was immediately transferred to the intensive care unit for cardiac monitoring and thrombolytic therapy .
an intravenous infusion of 1.5 million units of streptokinase over 50 min , followed by heparin at 900 u / h and one 325 mg tablet of aspirin and one 75 mg tablet of clopidogrel were administered .
the blood urea nitrogen level was 16 mg / dl and the creatinine level was 1.3 mg / dl .
u / l ( reference range : 8 - 40 ) , the aspartate aminotransferase level 180 u / l ( reference range : 8 - 30 ) , the alkaline phosphatase level 130 u / l ( reference range : 35 - 125 ) , total bilirubin level 0.8 mg / dl ( reference range : 0.2 - 1.2 mg / dl ) , the albumin level 4.4/dl ( reference range : 3.7 - 5.5 ) , and the total protein level 7.3 g / dl ( reference range : 6.0 - 8.0 ) . the white blood cell count was 11,000/mm , the hematocrit was 45.9% and the platelet count was 218,000/mm . also , creatinine kinase myocardial bound / creatinine kinase equal to 597/8932 u / l and elevated troponin - i level equal to 29 ng / ml were recognized .
after 8 hours of admission , the patient gradually developed shortness of breath , hypoxemia and fever ( 38.5c ) and after 3 h later , cough and hemoptysis developed .
finally , endotracheal intubation and mechanical ventilation was necessitated when hypoxemia ( sao2= 78% ) and symptoms of respiratory distress were present with a respiratory rate of 40/min .
laboratory tests showed a fall in the hemoglobin level from 15.8 to 12 g / dl within 20 h , and to 9 g / dl within 48 h ; so two units of packed cell were administered .
activated partial thromboplastin time was 99 s. in addition , he received four units of fresh frozen plasma and eight units of cryoglobulin with the purpose of pulmonary hemorrhage control .
the lab tests of admission time showed normal coagulation , liver and kidney functions tests .
, the patient remained febrile ( 39.0c ) with constant and moderate hemoptysis . due to the increased blood urea nitrogen and creatinine during the 72 h after admission , bed - side hemodialysis according to the nephrology consult
bronchoscopy on the 3 day showed no lesion in the bronchial tree and broncho - alveolar lavage was positive for hemosiderin laden macrophages ( 90% ) and negative for acid fast bacillus .
computerized tomography of the chest on the 3 day revealed diffuse alveolar infiltrates [ figure 1 ] .
the results of anti - glomerular basement membrane antibody , antinuclear antibodies , anti - double - stranded deoxyribonucleic acid antibody , peripheral antineutrophil cytoplasmic antibodies ( p - anca ) , and cytoplasmic anca were all negative . computed tomography of the chest taken 3 days after the onset of hemoptysis , revealing diffuse alveolar infiltrates .
patchy consolidations are also seen in horizontal views ( a and b ) coronal views , ( c and d ) horizontal views the patient was intubated for 9 days with no significant improvement in his condition and in the 10 hospital day his blood pressure was not detected and cardiac rhythm became asystole ; in spite of cardiopulmonary resuscitation for 60 min he remained pulseless and eventually expired .
thrombolytic therapy with streptokinase is generally used in acute myocardial infarction and has obviously diminished morbidity and mortality from this condition . however , it can cause a variety of hemorrhagic and immunological complications .
pulmonary hemorrhage is an uncommon but a potentially life - threatening complication of thrombolytic therapy and should be regarded as one of the differential diagnoses of pulmonary infiltrates or dropping hemoglobin after thrombolytic therapy for acute myocardial infarction with no apparent bleeding site .
hemoptysis , acute anemia and new radiographic infiltrates are considered as the triad of the diagnosis .
pulmonary hemorrhage is usually diagnosed within 12 h to 5 days after initiating the thrombolytic therapy .
some predisposing factors include pneumonia , heart failure and chronic obstructive pulmonary disease that might be related to the development of the pulmonary hemorrhage .
a case report of immune - mediated diffuse pulmonary hemorrhage following streptokinase administration for acute myocardial infarction in a patient with pulmonary infection and concomitant cutaneous infection suggested that infections may predispose patients to developing pulmonary hemorrhage .
it is noteworthy that cocaine use has been connected with both acute and chronic cardiovascular diseases which comprise acute myocardial infarction as one the acute manifestations .
the occurrence of alveolar hemorrhage in our patient after thrombolytic therapy might be associated with the coexisting cocaine and tobacco abuse .
we report a 45-year - old man with antroseptal myocardial infarction who developed bilateral basal alveolar infiltrates after initiating the fibrinolytic therapy . 
 although thrombolytic therapy with streptokinase is generally used in the course of acute myocardial infarction and has diminished morbidity and mortality , pulmonary hemorrhage is an uncommon , but a potentially life - threatening complication that should be regarded as one of the differential diagnoses of pulmonary infiltrates or dropping hemoglobin with no apparent bleeding site .