You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["Protein", "Chemical"].

Please return the output as a JSON object of the format: {"Chemical" : ["Dexamethasone", ...], "Protein" : ["BRCA-1", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Synthesis and selected immunological properties of substituted quino[3,2-b]benzo[1,4]thiazines.
A new type of azaphenothiazines - tetracyclic quino[3,2-b]benzo[1,4]thiazines, possessing common substituents (H, CH3, Cl, Br, F, CF3, SCH3) in positions 8-10 and pharmacophoric aminoalkyl substituents in position 6, were obtained from diquinodithiin and 2,2'-dichloro-3,3'-diquinolinyl disulfide in several-step syntheses. Sixty one compounds, grouped as the 6H, 6-dialkylaminoalkyl, 6-acylaminoalkyl and sulfonylaminoalkyl derivatives, were tested for cytotoxicity, their effects on phytohemagglutin A (PHA)-induced proliferative response of human peripheral blood mononuclear cells (PBMC) and lipopolysaccharide (LPS)-induced tumor necrosis factor alpha (TNF-α) production by these cells. The compounds exhibited differential inhibitory activities in these tests and significantly varied in terms of cytotoxicity. The most promising compounds were tested for growth inhibition of leukemia L-1210 cells, colon cancer SV-948 cells and epidermal carcinoma A-341 cells. The most active compounds exhibited anticancer activity against these cell lines comparable to that of cisplatin. The structure-activity relationship of the compounds were discussed.
{"Chemical": ["CF3", "SCH3", "aminoalkyl", "6-dialkylaminoalkyl", "diquinodithiin", "6-acylaminoalkyl", "Br", "F", "2,2\u0027-dichloro-3,3\u0027-diquinolinyl disulfide", "sulfonylaminoalkyl", "tetracyclic quino[3,2-b]benzo[1,4]thiazines", "quino[3,2-b]benzo[1,4]thiazines", "cisplatin", "Cl", "H", "CH3", "azaphenothiazines"], "Protein": ["PHA", "tumor necrosis factor alpha", "TNF-\u03b1", "phytohemagglutin A"]}