You will be shown inclusion or exclusion criteria for a clinical trial. Given these criteria, your task is to extract all unique entities of the following types: ["Observation", "Condition", "Procedure", "Drug", "Temporal", "Multiplier", "Qualifier", "Negation", "ReferencePoint", "Scope", "Value", "Mood", "Device", "Visit", "Measurement", "Person"].

Please return the output as a JSON object of the format: {"Condition" : ["breast cancer", ...], "Device" : ["ports", ...], "Drug" : ["Atenolol", ...], "Measurement" : ["blood pressure", ...], "Mood" : ["suspected", ...], "Multiplier" : ["more than two", ...], "Negation" : ["no", ...], "Observation" : ["history", ...], "Person" : ["male", ...], "Procedure" : ["surgery", ...], "Qualifier" : ["severe", ...], "ReferencePoint" : ["enrollment", ...], "Scope" : ["infection", ...], "Temporal" : ["one day", ...], "Value" : ["50%", ...], "Visit" : ["ICU", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Patients will be excluded if they have had exposure to a total daily dose of MET 1000 mg bid for at least 2 weeks in the past 3 months;
Patients will be excluded if they could not tolerate MET during the recommended titration schedule outlined in the protocol;
Major neurological or medical illnesses that affect weight gain (e.g., unstable thyroid disease) or require a systemic medication that might impact weight or glucose regulation (e.g., diabetes mellitus [insulin], chronic renal failure [steroids]);
Fasting glucose = 126 mg/dL on 2 occasions during screening indicating need for prompt treatment;
If lab results are available in the last 6 months, then a serum creatinine =1.3 mg/dL on 2 occasions during screening and/or follow-up, indicating potential impairment of renal functioning;
Pregnant or breast feeding;
Children and caregivers who are unable to complete assessments for any reason;
{"Condition": ["not tolerate", "thyroid disease", "diabetes mellitus", "chronic renal failure"], "Device": [], "Drug": ["MET", "steroids", "insulin"], "Measurement": ["Fasting glucose", "serum creatinine"], "Mood": [], "Multiplier": ["1000 mg bid", "2 o", "2"], "Negation": [], "Observation": [], "Person": [], "Procedure": [], "Qualifier": ["unstable"], "ReferencePoint": [], "Scope": [], "Temporal": ["at least 2 weeks in the past 3 months"], "Value": ["=1.3 mg/dL", "= 126 mg/dL"], "Visit": []}