You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["HealthCareActivity", "InjuryOrPoisoning", "BodySubstance", "IntellectualProduct", "AnatomicalStructure", "SpatialConcept", "Chemical", "Bacterium", "MedicalDevice", "Organization", "BiomedicalOccupationOrDiscipline", "Finding", "BiologicFunction", "Virus", "ResearchActivity", "ClinicalAttribute", "PopulationGroup", "Eukaryote", "BodySystem", "Food", "ProfessionalOrOccupationalGroup"].

Please return the output as a JSON object of the format: {"Virus": ["HIV", ...], "Bacterium": ["MRSA", ...], "AnatomicalStructure": ["Lung", ...], "BodySystem": ["CNS", ...], "BodySubstance": ["Serum", ...], "Finding": ["Headache", ...], "InjuryOrPoisoning": ["Fracture", ...], "BiologicFunction": ["Death", ...], "HealthCareActivity": ["Biopsy", ...], "ResearchActivity": ["Clinical trial", ...], "MedicalDevice": ["Lenses", ...], "SpatialConcept": ["Camps", ...], "BiomedicalOccupationOrDiscipline": ["Forensic medicine", ...], "Organization": ["WHO", ...], "ProfessionalOrOccupationalGroup": ["Provider", ...], "PopulationGroup": ["Swimmers", ...], "Chemical": ["Gold", ...], "Food": ["Rice", ...], "IntellectualProduct": ["RPAM", ...], "ClinicalAttribute": ["Biomarker", ...], "Eukaryote": ["Dogs", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Thymosin β4: Roles in Development, Repair, and Engineering of the Cardiovascular System The burden of cardiovascular disease is a growing worldwide issue that demands attention. While many clinical trials are ongoing to test therapies for treating the heart after myocardial infarction (MI) and heart failure, there are few options doctors able to currently give patients to repair the heart. This eventually leads to decreased ventricular contractility and increased systemic disease, including vascular disorders that could result in stroke. Small peptides such as thymosin β4 (Tβ4) are upregulated in the cardiovascular niche during fetal development and after injuries such as MI, providing increased neovasculogenesis and paracrine signals for endogenous stem cell recruitment to aid in wound repair. New research is looking into the effects of in vivo administration of Tβ4 through injections and coatings on implants, as well as its effect on cell differentiation. Results so far demonstrate Tβ4 administration leads to robust increases in angiogenesis and wound healing in the heart after MI and the brain after stroke, and can differentiate adult stem cells toward the cardiac lineage for implantation to the heart to increase contractility and survival. Future work, some of which is currently in clinical trials, will demonstrate the in vivo effect of these therapies on human patients, with the goal of helping the millions of people worldwide affected by cardiovascular disease.
{"AnatomicalStructure": ["heart", "endogenous stem cell", "adult stem cells", "brain", "cardiac"], "Bacterium": [], "BiologicFunction": ["paracrine signals", "wound healing", "heart failure", "systemic disease", "Repair", "wound repair", "cell differentiation", "ventricular contractility", "vascular disorders", "cardiovascular disease", "neovasculogenesis", "contractility", "myocardial infarction", "fetal development", "angiogenesis", "stroke", "MI"], "BiomedicalOccupationOrDiscipline": [], "BodySubstance": [], "BodySystem": ["Cardiovascular System"], "Chemical": ["peptides", "Thymosin \u03b24", "coatings", "T\u03b24", "thymosin \u03b24"], "ClinicalAttribute": [], "Eukaryote": ["human"], "Finding": [], "Food": [], "HealthCareActivity": ["therapies", "administration", "injections", "repair the heart", "implantation"], "InjuryOrPoisoning": ["injuries"], "IntellectualProduct": ["goal"], "MedicalDevice": ["implants"], "Organization": [], "PopulationGroup": ["people"], "ProfessionalOrOccupationalGroup": ["doctors"], "ResearchActivity": ["clinical trials", "research"], "SpatialConcept": ["niche", "in vivo", "cardiovascular"], "Virus": []}