You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["HealthCareActivity", "InjuryOrPoisoning", "BodySubstance", "IntellectualProduct", "AnatomicalStructure", "SpatialConcept", "Chemical", "Bacterium", "MedicalDevice", "Organization", "BiomedicalOccupationOrDiscipline", "Finding", "BiologicFunction", "Virus", "ResearchActivity", "ClinicalAttribute", "PopulationGroup", "Eukaryote", "BodySystem", "Food", "ProfessionalOrOccupationalGroup"].

Please return the output as a JSON object of the format: {"Virus": ["HIV", ...], "Bacterium": ["MRSA", ...], "AnatomicalStructure": ["Lung", ...], "BodySystem": ["CNS", ...], "BodySubstance": ["Serum", ...], "Finding": ["Headache", ...], "InjuryOrPoisoning": ["Fracture", ...], "BiologicFunction": ["Death", ...], "HealthCareActivity": ["Biopsy", ...], "ResearchActivity": ["Clinical trial", ...], "MedicalDevice": ["Lenses", ...], "SpatialConcept": ["Camps", ...], "BiomedicalOccupationOrDiscipline": ["Forensic medicine", ...], "Organization": ["WHO", ...], "ProfessionalOrOccupationalGroup": ["Provider", ...], "PopulationGroup": ["Swimmers", ...], "Chemical": ["Gold", ...], "Food": ["Rice", ...], "IntellectualProduct": ["RPAM", ...], "ClinicalAttribute": ["Biomarker", ...], "Eukaryote": ["Dogs", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Results of a Multicenter, Randomized, Controlled Trial of a Hydrogen Peroxide -based Kit versus a Benzoyl Peroxide -based Kit in Mild-to-moderate Acne Objective:To evaluate the efficacy and tolerability of a novel hydrogen peroxide -based regimen versus a benzoyl peroxide -based regimen in mild-to-moderate acne. Methods: In this eight- week multicenter study, patients were randomized to either a hydrogen peroxide -based or a benzoyl peroxide -based regimen .The primary outcome measure of clinical response was assessed using the Global Acne Grading System (GAGS) at baseline ,four weeks, and eight weeks. At Week 8, a patient self-satisfaction questionnaire was administered. Investigators were also queried at that time regarding assessment of tolerability and cosmetic acceptability. Tolerability was also measured at each visit. Results: Both treatment regimens were associated with improvement of GAGS score at Week 8 compared to baseline (p<0.0001). GAGS score did not differ significantly between the two regimens over the same period (p=0.7765). No significant adverse events were reported or observed in either treatment arm. Both patients and investigators found both regimens to be similarly effective and cosmetically acceptable. Conclusion: A novel hydrogen peroxide -based regimen was shown to be comparable in efficacy, safety, and cosmetic acceptability to a benzoyl peroxide -based regimen in the treatment of mild-to-moderate acne.
{"AnatomicalStructure": [], "Bacterium": [], "BiologicFunction": ["Acne", "acne"], "BiomedicalOccupationOrDiscipline": [], "BodySubstance": [], "BodySystem": [], "Chemical": ["Hydrogen Peroxide", "hydrogen peroxide", "Benzoyl Peroxide", "benzoyl peroxide"], "ClinicalAttribute": [], "Eukaryote": [], "Finding": ["clinical response", "No significant adverse events"], "Food": [], "HealthCareActivity": ["Global Acne Grading System", "reported", "regimen", "treatment regimens", "assessment", "GAGS", "regimens", "treatment", "visit", "evaluate"], "InjuryOrPoisoning": [], "IntellectualProduct": ["self-satisfaction questionnaire", "Controlled Trial", "Methods", "queried"], "MedicalDevice": ["Kit"], "Organization": [], "PopulationGroup": [], "ProfessionalOrOccupationalGroup": ["investigators", "Investigators"], "ResearchActivity": ["Tolerability", "Randomized", "randomized", "tolerability", "Multicenter", "treatment arm", "multicenter study"], "SpatialConcept": [], "Virus": []}