Given an abstract from a research paper, your task is to identify and label relationships between chemical compounds and genes mentioned in the abstract.

The relationship type must be one of ['DOWNREGULATOR', 'SUBSTRATE', 'INDIRECT-REGULATOR', 'PART-OF', 'MODULATOR-ACTIVATOR', 'REGULATOR', 'INHIBITOR', 'COFACTOR', 'UPREGULATOR', 'ACTIVATOR', 'ANTAGONIST', 'NOT', 'INDIRECT-DOWNREGULATOR', 'SUBSTRATE_PRODUCT-OF', 'INDIRECT-UPREGULATOR', 'AGONIST', 'PRODUCT-OF', 'MODULATOR', 'DIRECT-REGULATOR', 'UNDEFINED', 'AGONIST-INHIBITOR', 'AGONIST-ACTIVATOR', 'MODULATOR-INHIBITOR'].

Please format your output as a JSON array. Each entry in the array should express a single relation, formatted as ["<Entity_A>", "<RELATION_A_B>", "<Entity_B>"]. If no relations can be found, please output an empty JSON array [].

Abstract:

Pirfenidone inhibits TGF-beta expression in malignant glioma cells. Due to its immunosuppressive properties, the cytokine transforming growth factor (TGF) -beta has become a promising target in the experimental treatment of human malignant gliomas. Here, we report that the antifibrotic drug 5-methyl-1-phenyl-2- (1H) -pyridone (pirfenidone, PFD) elicits growth-inhibitory effects and reduces TGF-beta2 protein levels in human glioma cell lines. This reduction in TGF-beta2 is biologically relevant since PFD treatment reduces the growth inhibition of TGF-beta-sensitive CCL-64 cells mediated by conditioned media of glioma cells. The downregulation of TGF-beta is mediated at multiple levels. PFD leads to a reduction of TGF-beta2 mRNA levels and of the mature TGF-beta2 protein due to decreased expression and direct inhibition of the TGF-beta pro-protein convertase furin. In addition, PFD reduces the protein levels of the matrix metalloproteinase (MMP) -11, a TGF-beta target gene and furin substrate involved in carcinogenesis. These data define PFD or PFD-related agents as promising agents for human cancers associated with enhanced TGF-beta activity.
[["PFD", "INDIRECT-DOWNREGULATOR", "TGF-beta2"], ["pirfenidone", "INDIRECT-DOWNREGULATOR", "TGF-beta2"], ["5-methyl-1-phenyl-2- (1H) -pyridone", "INDIRECT-DOWNREGULATOR", "TGF-beta2"], ["Pirfenidone", "INDIRECT-DOWNREGULATOR", "TGF-beta"], ["PFD", "INHIBITOR", "pro-protein convertase"], ["PFD", "INDIRECT-DOWNREGULATOR", "matrix metalloproteinase (MMP) -11"], ["PFD", "INHIBITOR", "TGF-beta"], ["PFD", "REGULATOR", "TGF-beta"], ["PFD", "INHIBITOR", "furin"]]