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Paper text:
one hundred years ago , most western countries also experienced a high incidence of gastric cancer but mysteriously the incidence began to decline to where in many countries it has become an uncommon disease . in the early 20th century
gastric cancer was the number one cause of cancer in many countries ( e.g. , the united states , england , and germany ) leading to considerable interest in finding the cause . in the late 1800 's it
was recognized that there was a relationship between gastric cancer and achlorhydria ( atrophic gastritis ) and in the first half of the 20th century research focused on and confirmed the strong association between gastric cancer and atrophic gastritis .
numerous epidemiology studies on gastritis were done   and hypotheses were developed including how gastric cancer developed as part of the progression of the histologic damage .
the major breakthrough occurred in the early 1980 's when warren and marshall   cultured helicobacter pylori and proved that it caused gastritis .
they also speculated that , if h. pylori caused gastritis , it was also likely etiologically involved in the gastritis - associated diseases , peptic ulcer and gastric adenocarcinoma .
the world health organization declared h. pylori to be a class i ( definite ) human carcinogen . in 2014
the world health organization published a new monograph entitled " helicobacter pylori eradication as a strategy for preventing gastric cancer " describing the recent and ongoing epidemiologic studies regarding h. pylori eradication and gastric cancer . probably the most important recent change in thinking and management of h. pylori occurred in 2013 when the japanese government approved a test and treat strategy to find and eliminate h. pylori in order to eliminate gastric cancer in japan .
we now understand that cure of the infection will stop the progression of gastric damage but it will not completely reverse the accumulated risk of developing gastric cancer .
thus , the new japanese gastric cancer program also includes a secondary cancer prevention program utilizing endoscopic surveillance to find and remove early gastric cancers that appear despite h. pylori eradication .
h. pylori infection is classified as a " necessary but insufficient cause " of gastric cancer .
that is the same classification used for other infectious agents that are etiologically involved in carcinogenesis such as human papilloma virus ( cervical cancer ) , hepatitis b and c ( liver cancer ) and the epstein - barr virus ( also known as human herpesvirus 4 ) with causes burkitt 's lymphoma and nasopharyngeal carcinoma .
the " not sufficient " means that presence of one of these infections does not guarantee that the infected person will develop cancer but the specific type of associated cancer will not develop without the infection .
there are other less common causes of gastric cancer besides h. pylori ( e.g. , epstein - barr virus , primary genetic abnormalities ) such that eradication of h. pylori will not completely eliminate gastric cancer .
however , because h. pylori infection is responsible for more than 95% of gastric cancers , its eradication will make gastric cancer a truly rare disease .
thus , the decision of the japanese government to eliminate h. pylori was based on the premise that doing so would virtually eliminate the problems associated with the present high burden of gastric cancer .
the natural history of h. pylori gastritis is one of progressive histologic damage ultimately leading to atrophic gastritis and gastric atrophy .
gastric cancer is an inflammation - associated cancer   and the link to gastric cancer is through atrophic gastritis .
an individual 's risk can be stratified based on the extent and severity of the gastric damage .
a population 's risk can be estimated based on the average rate of development of atrophic changes .
the progression to atrophic gastritis is influenced by the virulence of the infecting h. pylori strain , environmental factors particularly diet , and host genetics .
dietary factors play an important role such that the gastric cancer environment is typically one where diets are seasonal ( e.g. , lack of fresh fruits and vegetables in winter ) and salt is commonly used as a food preservative .
for example , a change of diet to include one where refrigeration largely replaces salt in food preservation and fresh fruits and vegetables are available year around can result in rapid decline in the incidence of gastric cancer ( e.g. , by 60% in japan between 1965 and 1995 ) . in western countries
where the incidence of gastric cancer has fallen from the most common malignancy to an uncommon cancer has been associated both with a change in diet and improvements in sanitation resulting in a progressive decline in the prevalence of h. pylori infection .
h. pylori infections are typically acquired in childhood and remain active throughout an individual 's life .
improvements in standards of living and sanitation as has occurred in korea following world war ii resulted in a decline in transmission in families and thus a lower prevalence in each new birth cohort . this natural decline in prevalence of the infection requires many generations to reach sufficiently low levels to affect the incidence of gastric cancer .
the rate of disappearance can be accelerated by programs designed to identify and treat active infections as is being done in japan . however ,
if all h. pylori infections were eliminated today it would not immediately eliminate gastric cancer because those with irreversible damage would still have some remaining risk of developing cancer .
this is most easily visualized using a gastric cancer risk assessment tool such as the olga histologic staging system ( fig .
this system scores gastric cancer risk on a 5 point scale ( from 0 to 4 ) with 0 being no risk to 4 representing very high risk .
the natural history of h. pylori infection is for the cancer risk stage to increase over time ( i.e. , this is responsible for the age - related increase in gastric cancer ) ( fig .
. h. pylori eradication will stop the progression of damage and prevent further increases in risk which then stabilizes or declines ( fig .
cancer prevention in high risk countries such as korea requires that a program of h. pylori detection and eradication be combined with an estimation of cancer risk at the time of h. pylori eradication ( e.g. , histology , serum pepsinogen testing , or a combination of both ) ( fig .
the most common h. pylori strain infecting koreans is highly virulent and the korean diet tends to be of high salt content such that h. pylori infection frequently results in atrophic gastritis reflecting in the high rate of gastric one solution would be to follow japan 's lead and search out and eradicate h. pylori infections . because h. pylori - induced atrophic gastritis is common , a program to identify and perform surveillance on those with a significant gastric cancer risk should also be considered .
the current secondary cancer prevention program of annual or every 2 year endoscopy or radiology to detect cancer can be modified to include from for include primary prevention .
those in the current programs with no h. pylori infection or with non - atrophic gastritis receive little or no benefit ( fig .
4 )   and those at higher risk of cancer continue to experience the expected age - related increase in cancer risk despite surveillance . probably more than one - half of those currently enrolled in secondary cancer prevention programs fall into the " no possible benefit " category ( fig .
4 ) . the resources currently utilized for secondary gastric cancer prevention could possibly be better utilized by converting current secondary prevention programs into surveillance of the high risk group who have continuing risk despite h. pylori eradication ( fig .
the currently approved regimen ( a triple therapy consisting of a proton pump inhibitor , amoxicillin , and clarithromycin ) has proven to be relatively ineffective because of the high rate of clarithromycin resistance .
this therapy is considered obsolete in most countries but as it is often the only one approved by the government insurance , doctors have a dilemma .
while this is potentially available in korea it is rarely done and are there are few data about country - wide or even regional antibiotic resistance patterns . in the united states
we have moved toward four drugs combinations ( e.g. , 14 day therapy with a proton pump inhibitor , clarithromycin , metronidazole , and amoxicillin or concomitant therapy which is effective except in the presence of clarithromycin - metronidazole dual resistance ) or the combination of a bismuth , tetracycline , metronidazole and a proton pump inhibitor which is generally effective despite metronidazole resistance provided it is given a full dose and for 14 days . in asia
the combination of a high dose proton pump inhibitor and amoxicillin such as 20 mg of rabeprazole and 500 to 750 mg of amoxicillin every 6 hours for 14 days appears effective .
an organized program to identify the resistance patterns in korea and define regimens that are highly effective is clearly needed .
human experimentation with empiric therapies without susceptibility testing is an extremely inefficient method of discovery of effective therapies and should be strongly discouraged .
the guidelines for management of h. pylori have varied somewhat over time and between regions .
it is important to recognize that in most instances these " indications " were not designed as being indications to treat the infection but rather were indications to test for h. pylori .
this was based on the premise that h. pylori was a very common disease ( i.e. , at least one - half of the world 's population is infected ) and as most would not develop a clinical outcome , testing should be focused on those in whom a definite benefit was likely .
nonetheless , it was recommended that whenever the infection was diagnosed , the patient be treated unless there were compelling reasons not to .
the recognition that h. pylori eradication would also essentially eliminate gastric cancer caused a rethinking of whom to test .
it is important to recognize that the natural history of the infection is to cause progressive damage such that the presence of non - atrophic changes is likely only a stage in the infection but one in which h. pylori eradication is almost certain to prevent gastric cancer . in populations where
atrophic gastritis and gastric cancer is common , population wide screening and treatment is indicated .
korea , china , japan have such populations , high risk populations exist even in low gastric cancer incidence countries and are also potential targets for a test and treat strategy along with targeted secondary cancer prevention .
most gastric cancers result from an infectious disease caused by the common human bacterial pathogen , h. pylori
. gastric cancer can be prevented and virtually eliminated by elimination of the cause ( i.e. , h. pylori eradication ) .
the current focus is on how to implement a test and treat program for high gastric cancer risk populations . in korea
there are probably 30 million h. pylori infected individuals a proportion of whom already are at high risk and would likely benefit most if h. pylori eradication was followed by a secondary cancer prevention program utilizing endoscopic surveillance .
the majority of korean 's have not yet progressed beyond non - atrophic gastritis and only require h. pylori eradication to eliminate or greatly reduce their gastric cancer risk .
the advantage of h. pylori therapy is that cure is a one - off such that the benefits are permanent .
however it is yet unclear how to accomplish this goal in the most efficiently and cost - effective manner .
however , there is no reason to delay in approaching the goal of making korea an h. pylori and gastric cancer free country .
most gastric cancers are caused by infection with the common human bacterial pathogen , helicobacter pylori . 
 it is now accepted that gastric cancer can be prevented and virtually eliminated by h. pylori eradication and this knowledge was responsible for country - wide h. pylori eradication combined with secondary cancer prevention for those with residual risk that was introduced in japan in 2013 . 
 korea is a high h. pylori prevalence and high gastric cancer incidence country and a good candidate for a gastric cancer elimination program . 
 the presence of an h. pylori infection is now considered as an indication for treatment of the infection 
 . however , antimicrobial drug resistance is common among h. pylori in korea making effective therapy problematic . 
 country - wide studies of the local and regional antimicrobial resistance patterns are needed to choose the most appropriate therapies . 
 h. pylori and gastric cancer eradication can be both efficient and cost effective making it possible and practical to make korea h. pylori and gastric cancer free . 
 there is no reason to delay .