You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["HealthCareActivity", "InjuryOrPoisoning", "BodySubstance", "IntellectualProduct", "AnatomicalStructure", "SpatialConcept", "Chemical", "Bacterium", "MedicalDevice", "Organization", "BiomedicalOccupationOrDiscipline", "Finding", "BiologicFunction", "Virus", "ResearchActivity", "ClinicalAttribute", "PopulationGroup", "Eukaryote", "BodySystem", "Food", "ProfessionalOrOccupationalGroup"].

Please return the output as a JSON object of the format: {"Virus": ["HIV", ...], "Bacterium": ["MRSA", ...], "AnatomicalStructure": ["Lung", ...], "BodySystem": ["CNS", ...], "BodySubstance": ["Serum", ...], "Finding": ["Headache", ...], "InjuryOrPoisoning": ["Fracture", ...], "BiologicFunction": ["Death", ...], "HealthCareActivity": ["Biopsy", ...], "ResearchActivity": ["Clinical trial", ...], "MedicalDevice": ["Lenses", ...], "SpatialConcept": ["Camps", ...], "BiomedicalOccupationOrDiscipline": ["Forensic medicine", ...], "Organization": ["WHO", ...], "ProfessionalOrOccupationalGroup": ["Provider", ...], "PopulationGroup": ["Swimmers", ...], "Chemical": ["Gold", ...], "Food": ["Rice", ...], "IntellectualProduct": ["RPAM", ...], "ClinicalAttribute": ["Biomarker", ...], "Eukaryote": ["Dogs", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Endoscopic endonasal surgery for remission of Cushing's Disease caused by ectopic intracavernous macroadenoma: case report and literature review Complete surgical resection of an ACTH-secreting pituitary adenoma is the gold standard of treatment of Cushing's Disease. Ectopic location of these adenomas is an extremely rare condition that may compromise the diagnosis and surgical success. We present the first case of an ectopic intracavernous ACTH-secreting macroadenoma totally resected with endoscopic endonasal surgery (EES). A 36 year old female presented with Cushing syndrome. Increased ACTH, serum cortisol and free urine cortisol levels were identified, however the pituitary MRI failed to reveal a pituitary tumor; instead, a parasellar lesion in the left cavernous sinus (CS) was noticed. Inferior petrosal sinus sampling demonstrated a significant central -to- peripheral and lateralized left-sided ACTH gradient. The patient underwent EES. No tumor was found in the sella, however, the left CS was widely explored and a tumor was found lateral to the paraclival segment of the carotid artery. There were no complications following EES. Pathology confirmed the diagnosis of an ACTH-secreting adenoma. During the immediately postoperative course serum cortisol levels dropped below 5 mcg/dl. Postoperative MRI demonstrated complete tumor resection. At 20 months follow-up, the patient remains in clinical and biochemical remission of Cushing's Disease. Only 12 cases of ectopic intracavernous ACTH-secreting adenomas have been reported to date and all were microadenomas. The presence of an ectopic ACTH-secreting macroadenoma in the CS represents a surgical challenge. EES is the ideal approach for complete resection of ectopic intracavernous adenomas allowing for a wide exploration of the CS with no surgical complications.
{"AnatomicalStructure": ["sella", "carotid artery"], "Bacterium": [], "BiologicFunction": ["macroadenoma", "ACTH-secreting adenomas", "ACTH-secreting macroadenoma", "pituitary tumor", "tumor", "microadenomas", "ACTH-secreting pituitary adenoma", "adenomas", "complications", "ACTH-secreting adenoma", "Cushing\u0027s Disease", "Cushing syndrome"], "BiomedicalOccupationOrDiscipline": ["Pathology"], "BodySubstance": [], "BodySystem": [], "Chemical": ["ACTH", "serum cortisol"], "ClinicalAttribute": [], "Eukaryote": [], "Finding": ["no", "parasellar lesion", "remission", "No tumor", "diagnosis"], "Food": [], "HealthCareActivity": ["EES", "MRI", "surgery", "Inferior petrosal sinus sampling", "surgical", "exploration", "resection", "follow-up", "tumor resection", "endoscopic", "treatment", "pituitary MRI", "surgical resection", "Endoscopic"], "InjuryOrPoisoning": [], "IntellectualProduct": ["case report", "literature review"], "MedicalDevice": [], "Organization": [], "PopulationGroup": [], "ProfessionalOrOccupationalGroup": [], "ResearchActivity": [], "SpatialConcept": ["endonasal", "CS", "peripheral", "location", "cavernous sinus", "Ectopic", "lateral", "ectopic", "central"], "Virus": []}