You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["Chemical"].

Please return the output as a JSON object of the format: {"Chemical": ["Arsenic", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Decreased expression of hepatic low-density lipoprotein related protein 1 in hypothyroidism: a novel mechanism of atherogenic dyslipidemia in hypothyroidism. Background: The atherogenic effects of hypothyroidism on lipid metabolism could result, in part, from the reduced clearance of remnant lipoproteins. In this study, we investigated the expression of hepatic low-density lipoprotein receptor-related protein 1 (LRP1), a receptor for remnant lipoproteins, in hypothyroidism and the effect of triiodothyronine (T3) treatment on hepatic LRP1 expression. Methods: C57BL/6 mice were fed a normal diet (control group) or a low iodine diet supplemented with 0.15 % propylthiouracil (PTU/LI group) for 4 weeks. Mice in PTU/LI group were injected intraperitoneally with T3 (0, 30, and 150 μg/kg of body weight) for 7 days. HepG2 cells were incubated in fetal bovine serum (FBS) or charcoal-stripped FBS (CSS) with various concentrations of T3. The expression and function of LRP1 in liver samples and cells were analyzed. Results: Hypothyroidism was successfully induced in PTU/LI group mice. Hepatic LRP1 protein expression was lower in the PTU/LI group than the control group. T3 treatment up-regulated hepatic LRP1 protein expression in PTU/LI group mice. LRP1 expression in HepG2 cells was reduced after incubation in media containing CSS, which mimics hypothyroidism in vitro, and was recovered by T3 treatment. The protein expression of LRP1 in HepG2 cells was increased by T3 treatment in a dose-dependent manner up to 2.0 nM T3. However, LRP1 mRNA transcription was not affected by hypothyroidism conditions or T3 treatment, either in liver samples or HepG2 cells. T3 treatment on HepG2 cells increased cellular uptake of lipid-conjugated apolipoprotein E through LRP1. Conclusions: Our data demonstrate that hepatic LRP1 expression and function decrease in hypothyroidism and are regulated by thyroid hormone. These results suggest that in hypothyroidism, decreased expression of hepatic LRP1 may be associated with reduced clearance of circulating remnant lipoproteins.
{"Chemical": ["propylthiouracil", "thyroid hormone", "iodine", "PTU", "triiodothyronine"]}