Given an abstract from a research paper, your task is to identify and label relationships between chemical compounds and genes mentioned in the abstract.

The relationship type must be one of ['DOWNREGULATOR', 'SUBSTRATE', 'INDIRECT-REGULATOR', 'PART-OF', 'MODULATOR-ACTIVATOR', 'REGULATOR', 'INHIBITOR', 'COFACTOR', 'UPREGULATOR', 'ACTIVATOR', 'ANTAGONIST', 'NOT', 'INDIRECT-DOWNREGULATOR', 'SUBSTRATE_PRODUCT-OF', 'INDIRECT-UPREGULATOR', 'AGONIST', 'PRODUCT-OF', 'MODULATOR', 'DIRECT-REGULATOR', 'UNDEFINED', 'AGONIST-INHIBITOR', 'AGONIST-ACTIVATOR', 'MODULATOR-INHIBITOR'].

Please format your output as a JSON array. Each entry in the array should express a single relation, formatted as ["<Entity_A>", "<RELATION_A_B>", "<Entity_B>"]. If no relations can be found, please output an empty JSON array [].

Abstract:

Inhibitory effect of 1α,25-dihydroxyvitamin D₃ on excretion of JBP485 via organic anion transporters in rats. The aim of this study was to investigate the pharmacokinetic mechanism of interaction between JBP485 and 1α,25-dihydroxyvitamin D (3) [ 1,25 (OH) (2) D (3) ]. Rats were injected intraperitoneally with 0.64 nmol/kg/day 1,25 (OH) (2) D (3) in 1 ml/kg corn oil for 5 days. The plasma and urine concentrations of JBP485 after intravenous administration and the uptake of JBP485 in kidney slices in vitro were determined by liquid chromatography/tandem mass spectrometry. Quantitative polymerase chain reaction, western blotting, immunohistochemical analysis and immunofluorescence were used to determine the changes in the expression of organic anion transporter (Oat) 1 and Oat3 in rat kidney in response to 1,25 (OH) (2) D (3) treatment. The plasma concentrations and AUCs of JBP485 were significantly increased, while the renal clearance of JBP485 and uptake of JBP485 in kidney slices were significantly decreased after 1,25 (OH) (2) D (3) treatment. These results confirmed that 1,25 (OH) (2) D (3) inhibited renal excretion of JBP485. Moreover, 1,25 (OH) (2) D (3) decreased expression of Oat1 and Oat3 in rat kidney. Our results are novel in demonstrating an interaction between JBP485 and 1,25 (OH) (2) D (3) when they are co-administered. The mechanism of interaction between JBP485 and 1,25 (OH) (2) D (3) could be explained at least in part by inhibitory effect of 1,25 (OH) (2) D (3) on expression of Oats in rat kidney.
[["1,25 (OH) (2) D (3)", "INDIRECT-REGULATOR", "(Oat) 1"], ["1,25 (OH) (2) D (3)", "INDIRECT-REGULATOR", "organic anion transporter"], ["1\u03b1,25-dihydroxyvitamin D\u2083", "INDIRECT-REGULATOR", "organic anion transporters"], ["1,25 (OH) (2) D (3)", "INDIRECT-DOWNREGULATOR", "Oat1"], ["1,25 (OH) (2) D (3)", "INDIRECT-REGULATOR", "Oat3"], ["1,25 (OH) (2) D (3)", "INDIRECT-DOWNREGULATOR", "Oats"], ["1,25 (OH) (2) D (3)", "INDIRECT-DOWNREGULATOR", "Oat3"]]