You are presented with a paragraph from a COVID-19 literature. Classify the topics of this piece of text by choosing from the following categories:

- Epidemic Forecasting: The content relates to predictions about the spread of COVID-19.
- Treatment: The paragraph discusses therapeutic methods or medication for COVID-19.
- Prevention: The content covers measures to prevent the spread of COVID-19.
- Mechanism: The paragraph explains the biological mechanisms of the virus.
- Case Report: The content is a report of a COVID-19 case.
- Transmission: The paragraph discusses how COVID-19 is transmitted.
- Diagnosis: The content is about diagnosing COVID-19 in individuals.

Your classification should be provided as an element within a JSON array. The array should be formatted with topics enclosed in double quotes and separated by commas, following the JSON format, for example: ["Topic1", "Topic2", ...]. Include all applicable topics within the array. Your output should be a valid JSON array, and no additional text should be included in your response.

Article:

Introduction: One-hundred and forty patients at Croydon University Hospital received continuous positive airway pressure (CPAP) on a specialist respiratory ward, as a bridge to invasive mechanical ventilation (IMV) or as a ceiling of care for COVID-19. This retrospective study aimed to outline service expansion, patient characteristics and explore risk factors in outcomes. Results: Mean age of patients on CPAP was 64 years (standard deviation 12). The median number of days from admission to CPAP initiation was 1 day (interquartile range (IQR) 0-3), and time before successful wean off CPAP was 4 days (IQR 2-6). Twenty-eight-day mortality was 64%. Thirty-four per cent of patients went onto require IMV, 24% improved off CPAP and 41% were palliated. The 28-day non-survivor group were of older age, had statistically significant higher admission creatinine and higher peak oxygen requirement. Age above 65 years was associated with higher mortality (odds ratio 5.9; 95% confidence interval 2.63-13.3). Conclusion: CPAP is a viable ceiling-of-treatment option in those unsuitable for ventilation, and may even avoid the need for ventilation in others. Duration on CPAP may be useful for service provision to predict resource allocation. The rapidity from admission to CPAP initiation highlights the need for early ceilings of care to be established.
["Treatment"]