You will be shown inclusion or exclusion criteria for a clinical trial. Given these criteria, your task is to extract all unique entities of the following types: ["Observation", "Condition", "Procedure", "Drug", "Temporal", "Multiplier", "Qualifier", "Negation", "ReferencePoint", "Scope", "Value", "Mood", "Device", "Visit", "Measurement", "Person"].

Please return the output as a JSON object of the format: {"Condition" : ["breast cancer", ...], "Device" : ["ports", ...], "Drug" : ["Atenolol", ...], "Measurement" : ["blood pressure", ...], "Mood" : ["suspected", ...], "Multiplier" : ["more than two", ...], "Negation" : ["no", ...], "Observation" : ["history", ...], "Person" : ["male", ...], "Procedure" : ["surgery", ...], "Qualifier" : ["severe", ...], "ReferencePoint" : ["enrollment", ...], "Scope" : ["infection", ...], "Temporal" : ["one day", ...], "Value" : ["50%", ...], "Visit" : ["ICU", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

History of sensitivity to study medications or any of their excipients
RA cohort: Previous intolerance to MTX
Current treatment with antiplatelet therapy
Absolute indication for anti-platelet therapy
Need for chronic oral anticoagulant therapy
Severe hepatic impairment (eg, ascites and/or clinical signs of coagulopathy)
Renal failure (eGFR <30 or requiring dialysis)
A known bleeding diathesis, hemostatic or coagulation disorder, or prior major bleeding
Prior stroke
Active pathological bleeding
History of intracranial haemorrhage
Life expectancy <12 months based on investigator's judgement
Patients considered to be at risk of bradycardic events (e.g., known sick sinus syndrome or second or third degree atrioventricular [AV)] block) unless already treated with a permanent pacemaker
Anemia (hematocrit < 27%)
Platelet count < 100,000/ml
Concomitant use of strong CYP 3A inhibitors or inducers
History of thrombocytopenia or neutropenia
Pregnant or nursing women, or females with a positive pregnancy test at screening
Females of child bearing potential not using acceptable method of birth control prior to or during study
Concern for inability of the patient to comply with study procedures and/or follow up (eg, alcohol or drug abuse)
{"Condition": ["third degree atrioventricular [AV)] block", "pathological bleeding", "ascites", "sick sinus syndrome", "Pregnant", "stroke", "neutropenia", "major bleeding", "child bearing potential", "Renal failure", "sensitivity", "drug abuse", "bleeding diathesis", "nursing", "RA", "se) ", "Anemia", "thrombocytopenia", "tic or coa r, or pr", "ird de ventricular [AV)] block) unless alr", "Severe hepatic impairment", "coagulopathy", "intolerance", "intracranial haemorrhage", "bradycardic events", "coagulation disorder"], "Device": ["permanent pacemaker"], "Drug": ["MTX", "strong CYP 3A inhibitors", "nhibitors or y of thr", "study medications"], "Measurement": ["eGFR", "hematocrit", "pregnancy test", "Platelet count", "Life expectancy"], "Mood": ["clinical signs of", "Concern for", "requiring", "at risk of", "Absolute indication for", "Need for"], "Multiplier": [], "Negation": ["unless", "not"], "Observation": ["method of birth control", "History", "tient to y procedures a hol or dr", "tient to y procedures and/or follow up ("], "Person": ["Females", "women", "females"], "Procedure": ["dialysis", "chronic oral anticoagulant therapy", "anti-platelet therapy", "antiplatelet therapy"], "Qualifier": ["acceptable"], "ReferencePoint": ["screening"], "Scope": ["ascites and/or clinical signs of coagulopathy", "inability of the patient to comply with study procedures and/or follow up", "eGFR \u003c30 or requiring dialysis", "alcohol or drug abuse", "hematocrit \u003c 27%", "Pregnant or nursing women", "females with a positive pregnancy test at screening", "prior to or during study", "sick sinus syndrome or second or third degree atrioventricular [AV)] block", "thrombocytopenia or neutropenia"], "Temporal": ["Current", "Prior", "prior", "Active", "at screening", "during study", " study\n inabi"], "Value": ["\u003c 100,000/ml", "\u003c 27%", "\u003c30", "positive", "\u003c12 months"], "Visit": []}