You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["Brand", "UnapprovedDrug", "Drug", "DrugGroup"].

Please return the output as a JSON object of the format: {"Brand" : ["Aspirin", ...], "DrugGroup": ["Salicyclate", ...], "Drug": ["Phenobarbital", ...], "UnapprovedDrug": ["Heroin", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Although specific drug interaction studies have not been conducted with ALPHAGAN P, the possibility of an additive or potentiating effect with CNS depressants (alcohol, barbiturates, opiates, sedatives, or anesthetics) should be considered. Alpha-agonists, as a class, may reduce pulse and blood pressure. Caution in using concomitant drugs such as beta-blockers (ophthalmic and systemic), anti-hypertensives and/or cardiac glycosides is advised. Tricyclic antidepressants have been reported to blunt the hypotensive effect of systemic clonidine.It is not known whether the concurrent use of these agents with ALPHAGAN P in humans can lead to resulting interference with the IOP lowering effect. No data on the level of circulating catecholamines after ALPHAGAN P administration are available. Caution, however, is advised in patients taking tricyclic antidepressants which can affect the metabolism and uptake of circulating amines.
{"Brand": ["ALPHAGAN P"], "Drug": ["clonidine", "alcohol"], "DrugGroup": ["opiates", "CNS depressants", "cardiac glycosides", "tricyclic antidepressants", "Tricyclic antidepressants", "sedatives", "Alpha-agonists", "barbiturates", "anesthetics", "beta-blockers", "anti-hypertensives"], "UnapprovedDrug": []}