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spontaneous esophageal perforation ( boerhaave 's syndrome ) was first described by hermann boerhaave in 1724 ; it can easily prove fatal if the diagnosis is delayed more than 24 h after onset , although the mortality has improved recently .
it has been reported that chest x - ray , endoscopic examination , enhanced esophagography and computed tomography scan were available for rapid and precise diagnosis . however , treatment is often delayed because its diagnosis is confused .
the reason might be that the chief complaints , represented by chest pain , chest discomfort , fever , back pain or abdominal pain , are manifold in addition to the rarity of the disease . in cases diagnosed rapidly ,
such cases often combine septic shock and the indication for surgery is still disputable taking into consideration the patient 's tolerance and surgical stress .
we present a case of spontaneous esophageal perforation in a 68-year - old man treated with emergent surgery 96 h after onset who was discharged in good health 86 days after emergent surgery .
we successfully treated the patient using thoracic drainage and jejunostomy , and report this case with reference to the literature .
the patient was a 68-year - old man who vomited after consuming alcohol , followed shortly thereafter by epigastralgia .
vital signs were as follows : blood pressure 160/100 mm hg , pulse rate 105 beats/ min , respiratory rate 32 breaths / min , body temperature 38.3c and spo2 95% ( by mask at 3 l / min ) .
blood and laboratory data were as follows : white blood cell count 5,900/l , red blood cell count 411  10/l , hemoglobin 12.3 g / dl , neutrophils 81.7% , platelets 9.7  10/l , total protein 6.1 g / dl , albumin 2.4 g / dl , blood urea nitrogen 34 mg / dl , creatinine 1.2 mg / dl , creatine phosphokinase 111
iu / l , total bilirubin 0.6 mg / dl , na 142 meq / l , cl 108 meq / l , k 4.2 meq / l , c - reactive protein 40.2 mg / dl , and procalcitonin 12.5 ng / ml . chest x - ray showed left pleural effusion and cardiomegaly ( fig .
1b ) , but his general condition deteriorated and the patient was diagnosed with sepsis .
a 5-cm - long perforation was identified at the left side of the lower esophagus .
the left thoracic cavity was rinsed with 10 l of saline , and thoracic drainage was performed with chest tubes .
orally administered contrast medium was seen from the perforated esophagus as a fistula on postoperative day 20 ( pod20 ) ( fig .
the lesion of esophageal perforation was covered with regenerated epithelium on endoscopic observation on pod72 .
peroral intake was started on pod76 and the patient was discharged from hospital on pod86 .
recent numerous advances in surgical and nutritional techniques , powerful and selective antibiotics , and better postoperative intensive care have all contributed to significant improvements in the mortality and morbidity associated with esophageal perforation . however , standard or personalized treatment is now controversial because of the variety of disease seriousness .
delayed diagnosis has been considered as one of the reasons why disease seriousness varies because the onset is nonspecific , with symptoms such as vomiting and severe chest or epigastric pain .
sepsis due to mediastinitis or pyothorax progresses rapidly and the mortality rate doubles if diagnosis is delayed beyond 24 h . in the present case ,
the patient complained of severe epigastric pain and dyspnea , and chest x - ray showed left pleural effusion and cardiomegaly .
therefore heart failure was initially suspected and drainage was delayed . in determining treatment , the general condition of the patient , the degree of contamination and the state of the esophagus around the perforation represent the most important factors .
a consensus has been reached that esophageal perforation should be repaired and thoracic and mediastinal drainage should be performed when diagnosis is achieved within 24 h [ 4 , 5 , 6 , 7 , 8 ] .
in contrast , the treatment for cases diagnosed more than 24 h after onset has not reached a consensus . to date , cases with esophagectomy or simple adequate drainage have been reported .
postoperative leakage reportedly occurs in 83% of such cases treated over 24 h after onset . in our case ,
the patient developed septic shock and perforation extending to the thoracic cavity , so we selected surgical drainage and feeding jejunostomy for postoperative enteral nutrition .
in addition to drainage , enteral nutrition reportedly enhances the immune function of the intestinal mucosal barrier against fatal infection [ 10 , 11 ] and has been linked to protection from sepsis or multi - organ failure [ 12 , 13 ] .
therefore , the authors believe that adequate drainage and early enteral nutrition in cases such as the present one could be minimally invasive while providing great benefit for spontaneous esophageal perforation with delayed diagnosis , except that it took a longer period until oral intake could be started . in conclusion , it is unnecessary to say that rapid and precise diagnosis is important , and minimal invasive and adequate treatment based on the patient 's condition can rescue in situations of spontaneous esophageal perforation .
spontaneous esophageal perforation is relatively uncommon , but carries a high mortality rate if diagnosis or treatment is delayed . 
 we report the case of a 68-year - old man with spontaneous esophageal perforation who was successfully treated over 96 h after onset by thoracic drainage and jejunostomy for enteral nutrition . 
 he vomited after drinking alcohol , soon followed by epigastralgia . 
 heart failure was suspected on admission to another hospital . 
 spontaneous esophageal perforation was diagnosed 48 h after admission . 
 chest tube drainage was performed , but his general condition deteriorated and he was transferred to our hospital . 
 emergent surgery was performed and esophageal perforation combined with pyothorax and mediastinitis was identified on the left side of the lower esophagus . 
 the left thoracic cavity was rinsed and thoracic drainage was performed . 
 feeding jejunostomy was performed for postoperative enteral nutrition . 
 effective drainage and sufficient nutrition management appear extremely valuable in treating spontaneous esophageal perforation .