You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["Chemical"].

Please return the output as a JSON object of the format: {"Chemical": ["Arsenic", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Galectin-3 Deficiency Accelerates High-Fat Diet Induced Obesity and Amplifies Inflammation in Adipose Tissue and Pancreatic Islets. Obesity-induced diabetes is associated with low-grade inflammation in adipose tissue and macrophage infiltration of islets. We show that ablation of Galectin-3, a galactoside-binding lectin, accelerates high-fat diet-induced obesity and diabetes. Obese LGALS3(-/-) mice have increased body weight, amount of total visceral adipose tissue, fasting blood glucose and insulin levels, HOMA-IR and markers of systemic inflammation compared to diet-matched WT animals. Obese LGALS3(-/-) visceral adipose tissue exhibited increased incidence of Type-1 T and NKT lymphocytes and pro-inflammatory CD11c+CD11b macrophages and decreased CD4+CD25+FoxP3+ Tregs and M2 macrophages. Pronounced mononuclear cell infiltrate, increased expression of NLRP3 inflammasome and IL-1β in macrophages and increased accumulation of advanced glycation endproducts (AGE) and receptor for AGE (RAGE) expression were present in pancreatic islets of obese LGALS3(-/-) animals accompanied with elevated phosphorilated NFκB p65 and mature Caspase-1 protein expression in pancreatic and visceral adipose tissue. In vitro stimulation of LGALS3(-/-) peritoneal macrophages with lypopolysaccharide (LPS) and saturated fatty acid palmitate caused increased Caspase-1 dependent IL-1β production and increased phosphorilation of NFκB p65 compared to WT cells. Transfection of LGALS3(-/-) macrophages with NLRP3 siRNA attenuated IL-1β production in response to palmitate and LPS plus palmitate. Obtained results suggest important protective roles for Gal-3 in obesity-induced inflammation and diabetes.
{"Chemical": ["glucose", "palmitate"]}