Given an abstract from a research paper, your task is to identify and label relationships between chemical compounds and genes mentioned in the abstract.

The relationship type must be one of ['DOWNREGULATOR', 'SUBSTRATE', 'INDIRECT-REGULATOR', 'PART-OF', 'MODULATOR-ACTIVATOR', 'REGULATOR', 'INHIBITOR', 'COFACTOR', 'UPREGULATOR', 'ACTIVATOR', 'ANTAGONIST', 'NOT', 'INDIRECT-DOWNREGULATOR', 'SUBSTRATE_PRODUCT-OF', 'INDIRECT-UPREGULATOR', 'AGONIST', 'PRODUCT-OF', 'MODULATOR', 'DIRECT-REGULATOR', 'UNDEFINED', 'AGONIST-INHIBITOR', 'AGONIST-ACTIVATOR', 'MODULATOR-INHIBITOR'].

Please format your output as a JSON array. Each entry in the array should express a single relation, formatted as ["<Entity_A>", "<RELATION_A_B>", "<Entity_B>"]. If no relations can be found, please output an empty JSON array [].

Abstract:

Caffeic Acid Phenethyl Ester Suppresses Proliferation and Survival of TW2.6 Human Oral Cancer Cells via Inhibition of Akt Signaling. Caffeic acid phenethyl ester (CAPE) is a bioactive component extracted from honeybee hive propolis. Our observations indicated that CAPE treatment suppressed cell proliferation and colony formation of TW2.6 human oral squamous cell carcinoma (OSCC) cells dose-dependently. CAPE treatment decreased G1 phase cell population, increased G2/M phase cell population, and induced apoptosis in TW2.6 cells. Treatment with CAPE decreased protein abundance of Akt, Akt1, Akt2, Akt3, phospho-Akt Ser473, phospho-Akt Thr 308, GSK3β, FOXO1, FOXO3a, phospho-FOXO1 Thr24, phospho-FoxO3a Thr32, NF-κB, phospho-NF-κB Ser536, Rb, phospho-Rb Ser807/811, Skp2, and cyclin D1, but increased cell cycle inhibitor p27Kip. Overexpression of Akt1 or Akt2 in TW2.6 cells rescued growth inhibition caused by CAPE treatment. Co-treating TW2.6 cells with CAPE and 5-fluorouracil, a commonly used chemotherapeutic drug for oral cancers, exhibited additive cell proliferation inhibition. Our study suggested that administration of CAPE is a potential adjuvant therapy for patients with OSCC oral cancer.
[["CAPE", "INDIRECT-DOWNREGULATOR", "Akt"], ["CAPE", "NOT", "Akt2"], ["CAPE", "INDIRECT-DOWNREGULATOR", "FOXO3a"], ["CAPE", "INDIRECT-DOWNREGULATOR", "phospho-FoxO3a"], ["CAPE", "INDIRECT-DOWNREGULATOR", "phospho-Akt"], ["CAPE", "INDIRECT-DOWNREGULATOR", "NF-\u03baB"], ["Caffeic Acid Phenethyl Ester", "INDIRECT-DOWNREGULATOR", "Akt"], ["CAPE", "INDIRECT-DOWNREGULATOR", "Akt3"], ["CAPE", "INDIRECT-DOWNREGULATOR", "phospho-FOXO1"], ["CAPE", "INDIRECT-DOWNREGULATOR", "Rb"], ["CAPE", "INDIRECT-DOWNREGULATOR", "GSK3\u03b2"], ["CAPE", "INDIRECT-DOWNREGULATOR", "Akt2"], ["CAPE", "INDIRECT-UPREGULATOR", "p27Kip"], ["CAPE", "INDIRECT-DOWNREGULATOR", "FOXO1"], ["CAPE", "NOT", "Akt1"], ["CAPE", "INDIRECT-DOWNREGULATOR", "phospho-Rb"], ["CAPE", "INDIRECT-DOWNREGULATOR", "cyclin D1"], ["CAPE", "INDIRECT-DOWNREGULATOR", "Akt1"], ["CAPE", "INDIRECT-DOWNREGULATOR", "Skp2"], ["CAPE", "INDIRECT-DOWNREGULATOR", "phospho-NF-\u03baB"]]