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Paper text:
recently , it has been suggested that infection with helicobacter pylori may have a pathogenic role in diabetes mellitus.13 however , there is no definite evidence regarding the role of h. pylori infection that may cause insulin resistance . in the present study
, we aimed to elucidate whether h. pylori deteriorates glycemic control in subjects with diabetes mellitus .
to do so , we retrospectively investigated the effect of eradication therapy on h. pylori and how it might affect glycemic control in japanese subjects with type 2 diabetes .
the study included a total of 72 subjects with type 2 diabetes who received eradication therapy for h. pylori during 6 years from 2006 to 2011 .
they included 55 male and 17 female subjects , aged 63.7 [ standard error ( se ) 1.1 ] years , and we checked a1c levels regularly in our division . at first , the subjects were pathologically diagnosed with h. pylori infection by upper gastrointestinal endoscopy .
the eradication therapy for h. pylori was performed using oral administration of amoxicillin 1500 mg / day , clarithromycin 800 mg / day with lansoprazole 60 mg / day ( n = 65 ) or omeprazole 40 mg / day ( n = 2 ) , or rabeprazole 40 mg/ day ( n = 5 ) for 7 days .
the eradication was evaluated by urea breath test and the subjects who failed to eradicate h. pylori were excluded . the blood glycosylated hemoglobin ( a1c )
levels were evaluated 3 months before ( 3 m ) the eradication therapy , as well as 3 months ( 3 m ) and 6 months ( 6 m ) after .
the subjects had been treated with sulfonylureas ( 58.3% ) , alpha - glucosidase inhibitors ( 19.4% ) , biguanides ( 18.1% ) , dipeptidyl pep - tidase-4 inhibitors ( 9.7% ) , glinides ( 4.2% ) and thiazo - lidinedione ( 1.4% ) , or with insulin ( 11.1.% ) ; 27.8% of subjects did not receive any medications .
an unpaired t - test was used to compare a1c levels before and after the eradication .
statistical analysis was performed with spss - ii ( spss inc , chicago , il , usa ) for windows ( microsoft corporation , redmond , wa ) .
the a1c levels before and after the eradication therapy for h. pylori did not show any significant changes in subjects with type 2 diabetes { 6.9 [ 0.1]% ( 3 m ) to 7.0 [ 0.1]% ( 3 m ) ; p = 0.3 , 7.0 [ 0.1 ] ( 6 m ) ; p = 0.3 } ( fig .
scatter plotting also revealed that the a1c levels of each subject had not been changed during the study period ( fig .
infection with h. pylori has been recently suggested to be associated with an increased rate of diabetes mellitus.2 a previous report found that h. pylori infection might be associated with insulin - dependent diabetes mellitus.1 a case report from japan has also suggested that the eradication of h. pylori may result in the amelioration of insulin resistance in a patient with type b insulin resistance , ( ie , insulin receptor autoantibodies).3 however , another case report from japan indicated that the eradication of h. pylori might trigger the onset of type 1 diabetes.4 although our study is limited by the fact that it is a retrospective analysis from one center with a small number of subjects , the present findings suggest that eradication therapy for h. pylori does not , at least profoundly , affect glycemic control in japanese subjects with type 2 diabetes .
further investigation is needed to determine whether autoantibodies against insulin or islet cells possibly triggered by h. pylori infection might be an irreversible process .
the eradication therapy for h. pylori does not seem to affect glycemic control in japanese subjects with type 2 diabetes .
since infection with helicobacter pylori has been suggested to play a pathogenic role in diabetes mellitus , we investigated whether eradication therapy for h. pylori might affect glycemic control in japanese subjects with type 2 diabetes . 
 a total of 72 subjects ( 55 males , 17 females ; aged 63.7 years ) with type 2 diabetes who received eradication therapy for h. pylori were included . 
 the change of their blood glycosylated hemoglobin ( a1c ) levels 3 months before ( 3 m ) the h. pylori eradication , as well as 3 months ( 3 m ) and 6 months ( 6 m ) after were evaluated . 
 their a1c levels did not show any significant change after therapy { 6.9 [ 0.1]% ( 3 m ) to 7.0 [ 0.1]% ( 3 m ) ; p = 0.3 , 7.0 [ 0.1 ] ( 6 m ) ; p = 0.3}. our findings suggest that the eradication therapy for h. pylori does not , at least profoundly , affect glycemic control in japanese subjects with type 2 diabetes .