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treatments for intratumoral hemorrhage in renal angiomyolipoma ( aml ) include nephron - sparing surgery , radical nephrectomy , and transcatheter arterial embolization .
superselective coil embolization is an effective , minimally invasive procedure for the treatment of intratumoral hemorrhage in aml from the perspectives of stopping bleeding and preserving the normal renal parenchyma .
however , it remains unknown which is the most appropriate embolization material to use when the hemodynamics of a ruptured aneurysm resemble those of a high - flow renal arteriovenous ( av ) fistula due to direct communication with the renal vein .
a 38-year - old woman developed acute , severe pain from the left neck to the lower back during exercise .
however , because her c - reactive protein level remained high and the back pain persisted she was referred to our hospital . upon admission , she described pain radiating from the left lower back to the shoulder and physical examination revealed a large , tender , palpable mass between the left subcostal region and the iliac crest .
her vital signs were as follows : blood pressure , 110/64 mm hg ; heart rate , 78 beats / min , and body temperature , 38.8c .
laboratory investigations showed white blood cell count , 7,100/l ; red blood cell count , 2.73  10/l ; hemoglobin , 8.5 g / dl ; platelet count , 280  10/l , and hematocrit , 25.9% .
contrast - enhanced ct showed a retroperitoneal mass ( 15  10  10 cm ) protruding from the left renal upper pole with fat attenuation suggesting aml ( fig .
an intratumoral hematoma measuring 7 cm in diameter was equally enhanced with the artery during the arterial phase of a dynamic study .
immediate left renal angiography revealed a tumor reaching from the left renal upper pole to the middle pole .
the arteries feeding the aml originated from the upper pole branches of the left renal artery and contained several aneurysms .
the outermost aneurysm had ruptured into the tumor , causing an intratumoral hematoma to form ( fig .
the blood flowed counter - clockwise within the intratumoral hematoma and moved from the hematoma to the left renal vein and inferior vena cava in a manner that hemodynamically resembled a high - flow renal av fistula ( fig .
, we placed 13 ( 3 of 5 mm  10 cm , 8 of 4 mm  8 cm , and 2 of 3 mm  8 cm ) guglielmi detachable coils ( gdc ; stryker , kalamazoo , mich .
, usa ) , five 3  2 mm pushable coils ( vortx 18 diamond shaped fibered platinum coils ; boston scientific corporation , boston , mass . ,
usa ) , and seven 3  2 mm pushable coils ( tornado ; cook medical inc . ,
usa ) in the ruptured aneurysm and feeding artery , and placed the coils as tightly as possible to stop extravasation .
left renal arteriography after embolization showed only minor leakage into the hematoma and no embolization of the normal renal parenchyma ( fig .
no further embolizations were performed because the minor leakage was too small for the embolization to be effective .
furthermore , since an arterial branch to the normal renal parenchyma was located close to the proximal embolization , additional embolization may have affected the normal renal parenchyma .
the ct numbers in the hematoma did not increase at any phase of a dynamic contrast study , suggesting the absence of leakage from the embolized aneurysm into the tumor .
the patient was discharged 10 days after embolization and her clinical course was uneventful . a 66-year - old woman developed low - grade fever that persisted for 10 days . despite taking medication prescribed by her local clinic ,
after 1 week the fever had increased to > 38c and left flank pain had developed , so she was referred to our hospital . upon admission , she described left flank pain and abdominal fullness .
her vital signs were as follows : blood pressure , 136/78 mm hg ; heart rate , 93 beats / min , and body temperature , 37.9c .
laboratory investigations showed white blood cell count , 12,000/l ; red blood cell count , 3.74  10/l ; hemoglobin , 11.1 g / dl ; platelet count , 344  10/l , and hematocrit , 37.4% .
abdominal three - dimensional ct angiography image showed a large left renal aml ( 12  11  9 cm ) containing a ruptured intratumoral aneurysm that was producing both an intratumoral hematoma ( fig .
2a ) and an av fistula with early venous return . left renal angiography confirmed the presence of a ruptured intratumoral aneurysm creating the av fistula ( fig .
as the av fistula was small , we placed 20 ( 10 of 3  2 mm , 4 of 4  2 mm , 5 of 5  2 mm , and 1 of 6  2 mm ) pushable coils ( tornado ; cook medical inc . ) in the ruptured aneurysm and tumor - feeding artery to stop the intratumoral bleeding and the av fistula formation .
an additional tumor - feeding artery was embolized with gelpart to reduce the tumor size . left renal angiography after embolization showed that the ruptured aneurysm and av fistula had been successfully embolized without embolization of the normal renal parenchyma ( fig . 2c ) .
a 38-year - old woman developed acute , severe pain from the left neck to the lower back during exercise .
however , because her c - reactive protein level remained high and the back pain persisted she was referred to our hospital . upon admission , she described pain radiating from the left lower back to the shoulder and physical examination revealed a large , tender , palpable mass between the left subcostal region and the iliac crest .
her vital signs were as follows : blood pressure , 110/64 mm hg ; heart rate , 78 beats / min , and body temperature , 38.8c .
laboratory investigations showed white blood cell count , 7,100/l ; red blood cell count , 2.73  10/l ; hemoglobin , 8.5 g / dl ; platelet count , 280  10/l , and hematocrit , 25.9% .
contrast - enhanced ct showed a retroperitoneal mass ( 15  10  10 cm ) protruding from the left renal upper pole with fat attenuation suggesting aml ( fig .
an intratumoral hematoma measuring 7 cm in diameter was equally enhanced with the artery during the arterial phase of a dynamic study .
immediate left renal angiography revealed a tumor reaching from the left renal upper pole to the middle pole .
the arteries feeding the aml originated from the upper pole branches of the left renal artery and contained several aneurysms .
the outermost aneurysm had ruptured into the tumor , causing an intratumoral hematoma to form ( fig .
the blood flowed counter - clockwise within the intratumoral hematoma and moved from the hematoma to the left renal vein and inferior vena cava in a manner that hemodynamically resembled a high - flow renal av fistula ( fig .
, we placed 13 ( 3 of 5 mm  10 cm , 8 of 4 mm  8 cm , and 2 of 3 mm  8 cm ) guglielmi detachable coils ( gdc ; stryker , kalamazoo , mich .
, usa ) , five 3  2 mm pushable coils ( vortx 18 diamond shaped fibered platinum coils ; boston scientific corporation , boston , mass . ,
usa ) , and seven 3  2 mm pushable coils ( tornado ; cook medical inc . ,
usa ) in the ruptured aneurysm and feeding artery , and placed the coils as tightly as possible to stop extravasation .
left renal arteriography after embolization showed only minor leakage into the hematoma and no embolization of the normal renal parenchyma ( fig .
no further embolizations were performed because the minor leakage was too small for the embolization to be effective .
furthermore , since an arterial branch to the normal renal parenchyma was located close to the proximal embolization , additional embolization may have affected the normal renal parenchyma .
the ct numbers in the hematoma did not increase at any phase of a dynamic contrast study , suggesting the absence of leakage from the embolized aneurysm into the tumor .
a 66-year - old woman developed low - grade fever that persisted for 10 days . despite taking medication prescribed by her local clinic ,
after 1 week the fever had increased to > 38c and left flank pain had developed , so she was referred to our hospital . upon admission , she described left flank pain and abdominal fullness .
her vital signs were as follows : blood pressure , 136/78 mm hg ; heart rate , 93 beats / min , and body temperature , 37.9c .
laboratory investigations showed white blood cell count , 12,000/l ; red blood cell count , 3.74  10/l ; hemoglobin , 11.1 g / dl ; platelet count , 344  10/l , and hematocrit , 37.4% .
abdominal three - dimensional ct angiography image showed a large left renal aml ( 12  11  9 cm ) containing a ruptured intratumoral aneurysm that was producing both an intratumoral hematoma ( fig .
2a ) and an av fistula with early venous return . left renal angiography confirmed the presence of a ruptured intratumoral aneurysm creating the av fistula ( fig .
as the av fistula was small , we placed 20 ( 10 of 3  2 mm , 4 of 4  2 mm , 5 of 5  2 mm , and 1 of 6  2 mm ) pushable coils ( tornado ; cook medical inc . ) in the ruptured aneurysm and tumor - feeding artery to stop the intratumoral bleeding and the av fistula formation .
an additional tumor - feeding artery was embolized with gelpart to reduce the tumor size . left renal angiography after embolization showed that the ruptured aneurysm and av fistula had been successfully embolized without embolization of the normal renal parenchyma ( fig . 2c ) .
renal amls are common benign neoplasms composed of fatty tissue , smooth muscle , and blood vessels .
although most amls are asymptomatic , 6880% of patients become symptomatic if the tumor reaches 4 cm in size .
the classic lenk 's triad of renal aml includes flank pain , a palpable tender mass , and signs of internal bleeding ( e.g. , hematuria ) .
aneurysms are most likely to rupture if they are 5 mm in size and the tumor is 4 cm in size . in the present report , case 1 was a 15  10  10 cm tumor with several 4- to 9-mm aneurysms , and case 2 was a 12  11  9 cm tumor with a 5-mm aneurysm . in both cases ,
one of the intratumoral aneurysms had ruptured and intratumoral arterial bleeding without extratumoral bleeding was evident .
patients with a ruptured aml often present with acute pain as a result of hemorrhage , and 20% are in hypovolemic shock at the time of initial presentation .
although the hemoglobin value was decreased in both patients presented here , neither were in hypovolemic shock because the hemorrhage was limited to the tumor and the blood was returned to the systemic blood flow either from the hematoma through the left renal vein ( case 1 ) or through direct communication with the left renal vein ( case 2 ) .
the aneurysms were selectively embolized by using a microcatheter and either a stack of detachable and pushable coils ( case 1 ) or pushable coils only ( case 2 ) . in both cases ,
the normal renal parenchyma was preserved by selectively embolizing the aneurysm ( case 1 ) or the aneurysm and tumor ( case 2 ) .
available embolization materials included polyvinyl alcohol foam powder ( pva ) with coils , pva with alcohol , alcohol with ethiodized oil , and sterile compressed sponge ( gelfoam , pfizer japan inc . ) .
the use of particle- or liquid - based embolization materials requires careful consideration because these materials can pass through the kidneys and tumor to the lungs .
pulmonary edema has been reported after embolization of a renal aml with alcohol and iodized oil .
furthermore , particle- or liquid - based embolization materials are not suitable for treating ruptured amls because of the presence of av fistula - like hemodynamics
. therefore , detachable and/or pushable coils are a more suitable option that allow compact , targeted embolization without the risk of causing pulmonary embolism . in conclusion ,
transcatheter arterial embolization is an effective first - choice therapy for the treatment of spontaneous intratumoral hemorrhage in aml in terms of rapid hemostasis , minimal invasiveness , and preservation of renal function .
therefore , it is preferable to open or laparoscopic approaches such as tumorectomy and nephrectomy . furthermore , careful observation of the hemodynamics of intratumoral ruptures is important before proceeding with transcatheter arterial embolization . in the case of ruptured tumor with av fistula
aneurysms within renal angiomyolipomas ( aml ) may rupture into the tumor or pararenal space . 
 transcatheter arterial embolization is the first - choice treatment to control bleeding . here 
 , we describe the use of coil embolization in two cases of spontaneous intratumoral hemorrhage with the hemodynamic characteristics of renal arteriovenous ( av ) fistula in renal aml . in case 1 , 
 renal angiography showed several intratumoral aneurysms , one of which had ruptured into the tumor , resulting in the formation of an intratumoral hematoma . 
 blood flow within the hematoma was rapid and the blood was immediately returned to the systemic circulation through the left renal vein . in case 2 , renal angiography showed that the rupture of an intratumoral aneurysm of a tumor - feeding artery had resulted in formation of an intratumoral hematoma and direct renal vein communication . 
 no extratumoral hemorrhage was observed in either case . 
 the hemodynamics of both hematomas resembled those of a high - flow renal av fistula . 
 the ruptured aneurysms were embolized with detachable and pushable coils ( case 1 ) or pushable coils only ( case 2 ) . to our knowledge , this is the first report of successful embolization of av fistula - like intratumoral hemorrhage in renal aml .