You will be presented with the full text of a biomedical research paper. Please write an abstract for this paper. Your response should include the abstract and no additional text.

Paper text:
well validated antibodies are crucial to enable scientists to make progress in a wide range of life science disciplines ranging from neuroscience to tissue engineering to plant science . evidence of validation is important as it allows scientists to choose antibodies that are fit for their experiments and avoid wasting time optimising antibodies that are unsuitable .
validation data also provides reviewers a guide as to whether the antibodies used in a manuscript are likely to give reliable results , something which helps to ensure experimental reproducibility , a topical issue in today s life sciences .
validating an antibody is a complicated process that can involve many different approaches ( 
 bordeaux 
 et al . , 2010 ; 
 howat 
 et al . , 2014 )
historically antibody validation commonly involved the now controversial antigen pre - adsorption test ( 
 holmseth 
 et al . , 2012 ) , while current studies may make use of knockout or knockdown tissue to demonstrate specificity .
there are also large scale approaches , capable of validating many antibodies simultaneously ( 
 holm 
 et al . , 2012 )
. however , there is no simple experiment that can validate an antibody for all possible applications and samples .
for example , validating an antibody for western blotting using a human cell line , does not guarantee the antibody will be suitable in immunohistochemistry using tissue from a rat .
instead antibody validation is a gradual process which involves testing the antibody for specific applications and species / tissues of interest , ideally using a number of approaches .
our aim is to encourage publishing of all independent studies , both positive and negative , which increase understanding of how antibodies perform .
these can range from large studies involving hundreds of antibodies , or the use of many tissues or cell lines , to small single figure studies focusing on an individual antibody in a specific setting .
the main criteria are ; the research group performing the validation should be independent from the company who supply the antibody , the experiments have been sufficiently repeated and the results are accurately and fully reported .
it is also crucial that the materials and methods provide enough detail to allow the experiments to be reproduced , something which is often not the case with studies using antibodies ( 
 helsby 
 et al . , 2013 ) . a key part of ensuring reproducibility is to make sure the antibodies can be identified by including their supplying company name and code and a resource identifier issued by the research identification initiative ( 
 http://scicrunch.com/resources ) . the instructions to authors ( 
 box 1 ) and guidelines for reviewers have been tailored to facilitate the aim of encouraging a broad range of papers , with a focus on reproducibility and accurate reporting , rather than perceived impact
extract from the instructions to authors 
 the antibody validation article collection aims to provide a platform for antibody validation studies and enhance the reliability and reproducibility of antibodies in scientific research .
referees reviewing validation studies will not focus on novelty and impact , but rather on whether the study is scientifically sound and provides all relevant information . 


f1000research accepts a variety of validation studies , which will be published as research notes : 

 new antibodies ; either against a new target or a new antibody raised against an existing target . 


new applications for existing antibodies ; either in a new biological system or a new application tested within an existing / previously tested biological system . 


existing antibody applied to a new biological system ; new organism / tissue / cell type . 


validations of previously tested antibodies that are carried out in more depth than before , in one or more applications . 


the antibody validation article collection aims to provide a platform for antibody validation studies and enhance the reliability and reproducibility of antibodies in scientific research .
referees reviewing validation studies will not focus on novelty and impact , but rather on whether the study is scientifically sound and provides all relevant information . 
 

f1000research accepts a variety of validation studies , which will be published as research notes : 
 
 new antibodies ; either against a new target or a new antibody raised against an existing target . 
 

new applications for existing antibodies ; either in a new biological system or a new application tested within an existing / previously tested biological system . 
 

existing antibody applied to a new biological system ; new organism / tissue / cell type . 
 

validations of previously tested antibodies that are carried out in more depth than before , in one or more applications . 
 

this broad approach should encourage a wide range of studies , many of which may never be published without this initiative and we hope that as the collection grows it will become a valuable resource for the thousands of researchers who use antibodies .
well validated antibodies are crucial to progress in a wide range of life science disciplines , but validating an antibody is a complex and ongoing process . 
 antibody validation is often carried out as preliminary work to a larger study so the validation data may go unpublished and needless duplication of efforts can occur . 
 this collection of articles in 
 f1000research provides a home for papers describing antibody validation studies . 
 our goal is to encourage publishing of all independent studies , both positive and negative , which increase understanding of how antibodies perform . 
 these could range from large studies with thousands of antibodies to small single figure studies which validate an individual antibody for a specific purpose . 
 opinion or correspondence articles considering any aspect of antibody validation are also welcome . here 
 , we provide an introduction to the collection which we hope will grow and become a valuable resource for the many thousands of researchers who use antibodies .