Given an abstract from a research paper, your task is to identify and label relationships between chemical compounds and genes mentioned in the abstract.

The relationship type must be one of ['DOWNREGULATOR', 'SUBSTRATE', 'INDIRECT-REGULATOR', 'PART-OF', 'MODULATOR-ACTIVATOR', 'REGULATOR', 'INHIBITOR', 'COFACTOR', 'UPREGULATOR', 'ACTIVATOR', 'ANTAGONIST', 'NOT', 'INDIRECT-DOWNREGULATOR', 'SUBSTRATE_PRODUCT-OF', 'INDIRECT-UPREGULATOR', 'AGONIST', 'PRODUCT-OF', 'MODULATOR', 'DIRECT-REGULATOR', 'UNDEFINED', 'AGONIST-INHIBITOR', 'AGONIST-ACTIVATOR', 'MODULATOR-INHIBITOR'].

Please format your output as a JSON array. Each entry in the array should express a single relation, formatted as ["<Entity_A>", "<RELATION_A_B>", "<Entity_B>"]. If no relations can be found, please output an empty JSON array [].

Abstract:

Peptide and non-peptide agonists and antagonists for the vasopressin and oxytocin V1a, V1b, V2 and OT receptors: research tools and potential therapeutic agents. Oxytocin (OT) and vasopressin (AVP) mediate their biological actions by acting on four known receptors: The OT (uterine) and the AVP V (1a) (vasopressor), V (1b) (pituitary), V (2) (renal) receptors and a fifth putative AVP V (1c) ? (vasodilating) receptor. This presentation will summarize some highlights of the recent progress, in the design and synthesis of selective peptide agonists, antagonists, radioiodinated ligands, fluorescent ligands and bivalent ligands for these receptors. Here we present published and unpublished pharmacological data on the most widely used agonists, antagonists and labelled ligands. The pharmacological properties of promising new selective OT antagonists and V (1b) agonists are also presented. This review should serve as a useful guide for the selection of the most appropriate ligand for a given study. The current status of non-peptide OT and AVP antagonists and agonists is also summarized. The relative merits of peptide and non-peptide AVP and OT agonists and antagonists as: (1) research tools and (2) therapeutic agents will be evaluated. Many of the receptor selective peptide agonists and antagonists from this and other laboratories are far more widely used as pharmacological tools for studies on the peripheral and central effects of OT and AVP than their non-peptide counterparts. In addition to OT and to a lesser extent AVP (pitressin), a number of OT and AVP analogues; such as carbetocin (OT agonist) dDAVP (desmopressin, V (2) agonist), terlipressin (V (1a) agonist), felypressin (V (1a) agonist) and atosiban (Tractocile OT antagonist) are also in clinical use. Despite much early promise, no non-peptide V (1a) or OT antagonists are currently in clinical trials. While a number of orally active non-peptide V (2) antagonists (Vaptans); notably, Tolvaptan, Lixivaptan and Satavaptan, are currently in Phase III clinical trials; to date, only the mixed V (2) /V (1a), antagonist Conivaptan (Vaprisol), has been approved by the US FDA for clinical use (by i.v. administration), for the treatment of euvolemic and hypervolemic hyponatremia in hospitalized patients. Promising new non-peptide V (1b) and OT antagonists, as well as non-peptide V (2) and OT agonists are now in pre-clinical development.
[["atosiban", "ANTAGONIST", "OT"], ["AVP", "REGULATOR", "V (1c"], ["AVP", "REGULATOR", "V (2"], ["Tractocile", "ANTAGONIST", "OT"], ["vasopressin", "REGULATOR", "V (1a"], ["vasopressin", "REGULATOR", "V (2"], ["felypressin", "AGONIST", "V (1a"], ["Tolvaptan", "ANTAGONIST", "V (2"], ["carbetocin", "AGONIST", "OT"], ["Satavaptan", "ANTAGONIST", "V (2"], ["vasopressin", "REGULATOR", "V (1b"], ["terlipressin", "AGONIST", "V (1a"], ["desmopressin", "AGONIST", "V (2"], ["AVP", "REGULATOR", "V (1a"], ["Lixivaptan", "ANTAGONIST", "V (2"], ["AVP", "REGULATOR", "V (1b"], ["vasopressin", "REGULATOR", "V (1c"]]