You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["HealthCareActivity", "InjuryOrPoisoning", "BodySubstance", "IntellectualProduct", "AnatomicalStructure", "SpatialConcept", "Chemical", "Bacterium", "MedicalDevice", "Organization", "BiomedicalOccupationOrDiscipline", "Finding", "BiologicFunction", "Virus", "ResearchActivity", "ClinicalAttribute", "PopulationGroup", "Eukaryote", "BodySystem", "Food", "ProfessionalOrOccupationalGroup"].

Please return the output as a JSON object of the format: {"Virus": ["HIV", ...], "Bacterium": ["MRSA", ...], "AnatomicalStructure": ["Lung", ...], "BodySystem": ["CNS", ...], "BodySubstance": ["Serum", ...], "Finding": ["Headache", ...], "InjuryOrPoisoning": ["Fracture", ...], "BiologicFunction": ["Death", ...], "HealthCareActivity": ["Biopsy", ...], "ResearchActivity": ["Clinical trial", ...], "MedicalDevice": ["Lenses", ...], "SpatialConcept": ["Camps", ...], "BiomedicalOccupationOrDiscipline": ["Forensic medicine", ...], "Organization": ["WHO", ...], "ProfessionalOrOccupationalGroup": ["Provider", ...], "PopulationGroup": ["Swimmers", ...], "Chemical": ["Gold", ...], "Food": ["Rice", ...], "IntellectualProduct": ["RPAM", ...], "ClinicalAttribute": ["Biomarker", ...], "Eukaryote": ["Dogs", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Targeting brain and peripheral plasticity of the lipidome in acute kainic acid - induced epileptic seizures in mice via quantitative mass spectrometry Epilepsy is a highly common chronic neurological disorder, manifested in many different types, affecting ~1% of the worldwide human population. The molecular mechanisms of epileptogenesis have not yet been clarified, and pharmacoresistance exhibited by 30-40% of epilepsy patients remains a major obstacle in medical care. Growing evidence indicates a role of lipid signalling pathways in epileptogenesis, thus lipid signals emerge as potential biomarkers for the onset and evolving course of the epileptic disorder, as well as potential therapeutic agents and targets. For this purpose, we applied a lipidomic strategy to unravel lipid alterations in brain regions, periphery tissues and plasma that are specific for acute epileptic seizures in mice at 1h after seizure induction by systemic kainic acid injection as compared to vehicle controls. Specifically, levels of (i) selected phospholipids and sphingomyelins, (ii) the endocannabinoids anandamide (AEA) and 2-arachidonoyl glycerol (2-AG), and the endocannabinoid -related compounds oleoylethanolamide (OEA) and palmitoylethanolamide (PEA), (iii) arachidonic acid (AA), (iv) selected eicosanoids, and (v) fatty acyl content of lipidome were determined in pulverized tissues from six brain regions of kainic acid induced epileptic seizure models and vehicle controls: hypothalamus, hippocampus, thalamus, striatum, cerebellum and cerebral cortex, and from peripheral organs, such as heart and lungs, and in plasma. Alterations in lipid levels after acute epileptic seizures as compared to non-seizure controls were found to be brain region - and periphery tissue - specific, including specific plasma lipid correlates, highlighting their value as marker candidates in translational research studies, and/or drug discovery and response monitoring.
{"AnatomicalStructure": ["tissues", "heart", "thalamus", "periphery tissue", "hypothalamus", "striatum", "cerebral cortex", "organs", "hippocampus", "cerebellum", "periphery tissues", "brain", "lungs"], "Bacterium": [], "BiologicFunction": ["chronic neurological disorder", "Epilepsy", "signals", "epileptic seizures", "epileptogenesis", "molecular mechanisms", "peripheral plasticity", "epilepsy", "epileptic seizure", "epileptic disorder", "seizure", "signalling pathways"], "BiomedicalOccupationOrDiscipline": [], "BodySubstance": ["plasma"], "BodySystem": [], "Chemical": ["oleoylethanolamide", "2-AG", "2-arachidonoyl glycerol", "endocannabinoid", "arachidonic acid", "phospholipids", "eicosanoids", "anandamide", "endocannabinoids", "sphingomyelins", "OEA", "PEA", "kainic acid", "lipid", "lipidomic", "therapeutic agents", "AA", "compounds", "AEA", "lipidome", "palmitoylethanolamide", "fatty acyl"], "ClinicalAttribute": ["biomarkers", "marker candidates"], "Eukaryote": ["mice", "human"], "Finding": [], "Food": [], "HealthCareActivity": ["care", "response monitoring", "quantitative mass spectrometry"], "InjuryOrPoisoning": [], "IntellectualProduct": [], "MedicalDevice": [], "Organization": [], "PopulationGroup": ["population"], "ProfessionalOrOccupationalGroup": [], "ResearchActivity": ["drug discovery", "research studies", "systemic", "pulverized", "injection", "strategy"], "SpatialConcept": ["brain region", "brain regions", "peripheral"], "Virus": []}