You will be shown an abstract from a biomedical research paper. Given this abstract, your task is to extract all unique entities of the following types: ["HealthCareActivity", "InjuryOrPoisoning", "BodySubstance", "IntellectualProduct", "AnatomicalStructure", "SpatialConcept", "Chemical", "Bacterium", "MedicalDevice", "Organization", "BiomedicalOccupationOrDiscipline", "Finding", "BiologicFunction", "Virus", "ResearchActivity", "ClinicalAttribute", "PopulationGroup", "Eukaryote", "BodySystem", "Food", "ProfessionalOrOccupationalGroup"].

Please return the output as a JSON object of the format: {"Virus": ["HIV", ...], "Bacterium": ["MRSA", ...], "AnatomicalStructure": ["Lung", ...], "BodySystem": ["CNS", ...], "BodySubstance": ["Serum", ...], "Finding": ["Headache", ...], "InjuryOrPoisoning": ["Fracture", ...], "BiologicFunction": ["Death", ...], "HealthCareActivity": ["Biopsy", ...], "ResearchActivity": ["Clinical trial", ...], "MedicalDevice": ["Lenses", ...], "SpatialConcept": ["Camps", ...], "BiomedicalOccupationOrDiscipline": ["Forensic medicine", ...], "Organization": ["WHO", ...], "ProfessionalOrOccupationalGroup": ["Provider", ...], "PopulationGroup": ["Swimmers", ...], "Chemical": ["Gold", ...], "Food": ["Rice", ...], "IntellectualProduct": ["RPAM", ...], "ClinicalAttribute": ["Biomarker", ...], "Eukaryote": ["Dogs", ...]}. The keys should be entity types and values should be lists of extracted entities belonging to the corresponding type. If you cannot find entities belonging to a specific type, the value should be [].

Only output the JSON object and do not include any additional text.

Abstract:

Cross-Species Rhesus Cytomegalovirus Infection of Cynomolgus Macaques Cytomegaloviruses (CMV) are highly species-specific due to millennia of co-evolution and adaptation to their host, with no successful experimental cross- species infection in primates reported to date. Accordingly, full genome phylogenetic analysis of multiple new CMV field isolates derived from two closely related nonhuman primate species, Indian-origin rhesus macaques (RM) and Mauritian -origin cynomolgus macaques (MCM), revealed distinct and tight lineage clustering according to the species of origin, with MCM CMV isolates mirroring the limited genetic diversity of their primate host that underwent a population bottleneck 400 years ago. Despite the ability of Rhesus CMV (RhCMV) laboratory strain 68-1 to replicate efficiently in MCM fibroblasts and potently inhibit antigen presentation to MCM T cells in vitro, RhCMV 68-1 failed to productively infect MCM in vivo, even in the absence of host CD8+ T and NK cells. In contrast, RhCMV clone 68-1.2, genetically repaired to express the homologues of the HCMV anti-apoptosis gene UL36 and epithelial cell tropism genes UL128 and UL130 absent in 68-1, efficiently infected MCM as evidenced by the induction of transgene -specific T cells and virus shedding. Recombinant variants of RhCMV 68-1 and 68-1.2 revealed that expression of either UL36 or UL128 together with UL130 enabled productive MCM infection, indicating that multiple layers of cross- species restriction operate even between closely related hosts. Cumulatively, these results implicate cell tropism and evasion of apoptosis as critical determinants of CMV transmission across primate species barriers, and extend the macaque model of human CMV infection and immunology to MCM, a nonhuman primate species with uniquely simplified host immunogenetics.
{"AnatomicalStructure": ["clone", "laboratory strain", "fibroblasts", "CD8+ T", "homologues", "NK cells", "genome", "T cells", "transgene"], "Bacterium": [], "BiologicFunction": ["anti-apoptosis", "infection", "Cytomegalovirus Infection", "express", "apoptosis", "cell tropism", "inhibit antigen presentation", "co-evolution", "expression", "infect", "virus shedding", "induction", "transmission", "infected", "epithelial cell tropism", "adaptation"], "BiomedicalOccupationOrDiscipline": ["immunology", "immunogenetics"], "BodySubstance": [], "BodySystem": [], "Chemical": ["UL128", "gene UL36", "Recombinant variants", "isolates", "UL36", "UL130", "genes UL128"], "ClinicalAttribute": [], "Eukaryote": ["primates", "cynomolgus macaques", "nonhuman primate", "Rhesus", "Cynomolgus Macaques", "RM", "human", "macaque", "rhesus macaques", "MCM", "primate"], "Finding": ["species of origin", "Indian-origin"], "Food": [], "HealthCareActivity": ["repaired"], "InjuryOrPoisoning": [], "IntellectualProduct": ["species", "model"], "MedicalDevice": [], "Organization": [], "PopulationGroup": ["MCM"], "ProfessionalOrOccupationalGroup": [], "ResearchActivity": ["phylogenetic analysis"], "SpatialConcept": ["Mauritian", "in vivo"], "Virus": ["CMV", "Cytomegaloviruses", "HCMV", "RhCMV"]}