You will be presented with the full text of a biomedical research paper. Please write an abstract for this paper. Your response should include the abstract and no additional text.

Paper text:
desmoid tumors are rare entities and belong to the group of fibromatoses , which arise from the connective tissue , fascia or aponeurosis of a muscle .  
even though desmoid tumors are benign lesions per definition , they show an infiltrative growth with destruction of surrounding structures and neighbouring organs , resulting in extensive morbidity .
the incidence is reported to be 2.4 bis 4.3 cases/1 million / year . in the majority desmoid tumors
are found intraabdominally and only a small amount of 715% are found in the head and neck area . as this tumor entity is rare , data giving evidence based recommendations for the optimal treatment algorithm for this disease
we report the case of a patient with a desmoid tumor of the right shoulder region that was diagnosed and treated interdisciplinary in the general surgery department for tumor resection , in our department for plastic surgical wound closure and in radio - oncology for adjuvant brachytherapy .
a 52-year old caucasian german male with no past medical history had observed a rapidly growing tumor of his right shoulder and slight soreness during a period of four weeks after having performed physical exercise for several weeks in a fitness studio .
an external magnet resonance imaging ( mri ) showed an 8x4x5.3 cm soft tissue tumor of the ventral shoulder below the deltoid muscle overlying the humerus head .
furthermore , the tumor had contact to the biceps muscle and the axillary perivascular sheath ( figure 1 ( fig .
resection was achieved without harming neuro - vascular structures but part of the deltoid muscle had to be excised .
after resection , the resulting wound cavity was too large to be closed by plain skin suture ( figure 2   a  c ( fig .
2 ) ) .   the final histology revealed an 8 cm mean diameter crude mass with elongated spindle - shaped cells , intertwined by a large amount of collagen - fibres .
the tumor expressed vimentin and actin but immuno - staining did not show pancytokeratin expression .
the s100 antigen , desmin and cd117 ( c - kit ) were negatively tested .
the patient underwent surgery for wound closure by a pedicle musculus latisimus dorsi flap from his right back and a sheet skin graft from his left thigh .
intraoperatively , region of radiation target area was marked by placing several metal surgical clips , as well as eight brachytherapy applicators ( plastic tubes ) which were implanted parallel using one cm interspacing between each tube ( figure 3 ( fig .
the applicators were fixed to the tumor bed with single sutures so that latero - lateral movement was blocked but longitudinal movement was kept free . after inserting the tubes through the skin they were fixed by special buttons , which were sutured to the skin to avoid longitudinal movements .
postoperatively , a multislice ct ( 1 mm slice thickness ) was performed in order to create a virtual model of anatomy and applicators .
based on this model , an individual volume optimized dose distribution was calculated by using the brachyvision software package ( varian , usa ) . after completing the fractionated image adapted brachytherapy treatment ( iabt ) the fixing buttons
were removed and the applicators could be extracted without any anaesthesia . during the postoperative course ,
because of the high risk of local recurrences in solitary surgery and the current tumor size of eight cm , radiation therapy ( rt ) was recommended in the interdisciplinary tumor board and brachytherapy was initiated with a total of 30 gy ( 2x2.5 gy in 8 days , no radiation on saturday and sunday ) two weeks after achievement of wound closure .
after completion of radiation , patient was treated by a physysiotherapist for the mobilization of the shoulder .
after 6 months a control mri was performed with no signs of a recurrent tumor .
the patient was very satisfied with the result of the muscle flap ( figure 5 ( fig .
the underlying cell differentiation contains spindle shaped cells , which are intertwined by collagen fibres .
the incidence is reported to be 2.4 bis 4.3 cases/1 million / year , whilst the majority of desmoid tumors are found intraabdominally and only 715% are found in the head and neck area .
when a surgeon is challenged by needing to treat the rare entity of a desmoid tumor , he needs to take the high risk of recurrence ( 2565% )   after surgery into account .  
the etiology of aggressive fibromatosis has not been sufficiently explained , but trauma , endocrine and genetic factors have been suggested to be causative .   in the presented case
this leads to the assumption , that the growth of the tumor could have been induced by this trauma to the muscle and its tendons .
diagnostics should be performed by ultrasound , mri or ct - scans . before any type of surgery is performed , the expansion of the tumor and its relation to functional structures and the neuro - vascular system need to be identified .
successful treatment of aggressive fibromatosis can be achieved by surgical excision , radiation and with pharmacological agents . in the current literature ,
radical surgical excision with tumor - free margins up to 3 cm is widely accepted and recommended , . however
, this often confronts the surgeon with the difficulty of having to sacrifice structures of functional or even vital importance .
if a complete resection can not be achieved because vital structures i.e. large blood vessels and vital organs are in danger , this fact consequently leads to local recurrence with a poor outcome .
further problems arise if a large wound cavity results , which can not be closed by direct skin suture .
nonetheless , radical excision should not be avoided , as sufficient wound closure can be provided by plastic surgery as shown in the present case .   in cases of incomplete resection ,
the role of adjuvant radiation or pharmacological treatment becomes even more important to limit the rate of recurrence and need to be discussed rationally in an interdisciplinary tumor board .  
there are studies , which emphasize the effectiveness of adjuvant radiation , , , , . however , a recent 24-year retrospective study demonstrated 3-year local control rates without significant differences after surgery , radiotherapy or a combination of both .
patients were selected for treatment branches according to the size of the tumor , the expansion of the tumor and the possibility of achieving margin free resection .
the actuarial 3-year local control rates ranged from 69.0% to 92.3% .   in a further retrospective study of 115 patients with desmoid tumors
described that the recurrence with rt alone can amount up to 32% in cases where surgery is not feasible due to gross disease .
patients treated with both surgery and rt showed a lower local recurrence of their tumor of 20% . yet in comparison the combination of surgery and rt did not prove to show different local control rates than in solitary rt .
additionally , in the case of positive resection margins , the combination of rt and surgery , did not show to be significantly associated with a lower rate of local control .
. demonstrated in a literature review that rt alone or surgery in combination with rt results in significantly better local control than just with solitary surgery . subdividing
the groups into cases with free and positive margins and cases with primary and recurrent tumors showed   that the best local control is achieved with rt or surgery with rt .
intraoperative radiotherapy was proven to be an effective treatment with low toxicity   and a total dose below 56 gy was recommended .
interstitial brachytherapy offers minimal normal tissue toxicity due to the steep dose fall - off of the sources and due to the intraoperative applicator placement the target tissue for postoperative radiotherapy can be defined optimally .
regarding total dose values , a national patterns of care study on radiotherapy of desmoid tumors   showed an over 80% cure rate in the adjuvant dose range of   3665 gy .
radiobiological modelling by the use of the linear - quadratic ( lq ) model allows the calculation of the biological equivalent dose ( bed ) of the used fractionation schedule   and results in a total bed of 46.5 gy on the reference isodose .
however , tissue volumes near to the applicators will be irradiated with higher dose ( for example the volume covered by the 200% isodose line with bed 93.0 gy ) .
the quality of the implant can be described by the dose non - homogeneity ratio ( dnr ) , which is the value of the 150% isodose volume divided by the covered volume of the 100% isodose line . in this case
pharmacological treatment of desmoids tumors offers further effective possibilities , if the biological properties and the patient 's characteristics are suitable .  
options are cytostatic chemotherapy , and non - cytotoxic agents such as hormonal , anti - inflammatory and biological agents .
unfortunately , also in the field of pharmacological treatment there is a lack of evidence due to non - sufficient patient numbers and missing prospective randomized studies .
this shows that it is more than ever necessary to establish treatment algorithms by inducing prospective multicenter studies  also in this rare entity .
the successful treatment of desmoid tumors requires an interdisciplinary approach . in cases of large tumors in need of wide excision
, a plastic surgeon needs to be consulted to ensure radical excision and sufficient wound closure .  
wound closure with viable tissue allows effective adjuvant radiation therapy . normal tissue sparing and effective
adjuvant therapy strategies are the implementation of perioperative image adapted brachytherapy techniques , as well pharmacological agents such as anti - estrogens ( i.e. tamoxifen ) and non - steroidal anti - inflammatory drugs ( nsaid ) .
there is a need for prospective randomized studies with larger numbers of patients to allow the development of standardized and evidence - based treatment algorithms .
written informed consent was obtained from the patient for publication of this case report and accompanying images .
a copy of the written consent is available for review by the editor - in - chief of this journal .
p. stollwerck recruited the patient , analyzed the data , performed the photography and wrote the manuscript .  
p. kujath and t. lange and t. bartscher performed the surgery , g. bohlen and g. kovcs performed image adapted brachytherapy as well they collected brachytherapy related radiobiology informations , f. stang reviewed the current literature , t. namdar and p. mailnder contributed in revising the manuscript .
written informed consent was obtained from the patient for publication of this case report and accompanying images .
a copy of the written consent is available for review by the editor - in - chief of this journal .
p. stollwerck recruited the patient , analyzed the data , performed the photography and wrote the manuscript .  
p. kujath and t. lange and t. bartscher performed the surgery , g. bohlen and g. kovcs performed image adapted brachytherapy as well they collected brachytherapy related radiobiology informations , f. stang reviewed the current literature , t. namdar and p. mailnder contributed in revising the manuscript .
desmoid tumors are non - metastatic mesenchymal tumors with an aggressive local growth . depending on the anatomic location , morbidity varies . 
 we report of a patient with a desmoid tumor of the right shoulder which was treated in our department by surgical excision , plastic - surgical wound closure and postoperative adjuvant radiation .