Use of Prokinetics in Early Enteral Feeding in Preterm Infants
Use of Prokinetics in Early Enteral Feeding in Preterm Infants
Objective of this study are:

 1) To determine if medication help extreme preterm infants to tolerate feeding better by
 reaching full feeding earlier.2) Out of two medication; which one is better for efficacy 1)
 Erythromycin 2) Metoclopramide. Infants who meet inclusion criteria would be entered to study
 after parental consent. Infant would be blinded to care givers. Infants will be randomized to
 receive one of three medication for 7-14 days. If infants fail on one medication they will be
 allowed to crossover to other medication. Infant would be allowed to treat like other
 infants. Blindness can be broken if deem necessary by attending neonatologist.
Inclusion Critera:

 1. Weight below 1250 grams

 2. Age less than 14 days

 3. Feeding intolerance; If feeding residual more than 30% on q3 hr feeding; 5 times out of
 8 times, feeding residual more than 20% on q4 hr feeding 4 feeding out of 6 feeding or
 failure to advance feeding of more than 20ml/kg in 72 hrs.

 Exclusion Criteria

 1. GI malformation or perforation

 2. Genetic disorder

 3. Parents can't read English. After consent, if infants meet inclusion criteria, he would
 be allowed to receive one of the following three medication. 1) Erythromycin at
 1mg/kg/dose q8 hr 2) Metoclopramide 0.1mg/kg/dose q8 hrs and Placebo. If infant fails to
 get better, he would be crossover to one of the remaining two.
Inclusion Criteria:

 1. Weight below 1250 grams

 2. Age less than 14 days

 3. Feeding intolerance; If feeding residual more than 30% on q3 hr feeding; 5 times out
 of 8 times, feeding residual more than 20% on q4 hr feeding 4 feeding out of 6 feeding
 or failure to advance feeding of more than 20ml/kg in 72 hrs.

 Exclusion Criteria

 1. GI malformation or perforation

 2. Genetic disorder

 3. Parents can't read English. After consent, if infants meet inclusion criteria, he
 would be allowed to receive one of the following three medication. 1) Erythromycin at
 1mg/kg/dose q8 hr 2) Metoclopramide 0.1mg/kg/dose q8 hrs and Placebo. If infant fails
 to get better, he would be crossover to one of the remaining two.