Mechanism of Aphasia and Recovery of Language After the Injury of Geschwind's Territory: a Study Based on the Brain Network Analysis
Mechanism of Aphasia and Recovery of Language After the Injury of Geschwind's Territory: a Study Based on the Brain Network Analysis
At present, functional imaging studies have suggested that the Geschwind's territory (the
 inferior parietal lobe) is an important language area. It is the hub for semantics and
 phonetic language processing. However, the type and mechanism of aphasia after injury of
 Geschwind's territory and the subsequent recovery of language are still unclear. In our study
 based on brain injury model of brain arteriovenous malformation (BAVMs) resection,
 investigators found that the incidence of aphasia was higher after the injury of Geschwind's
 territory than after injury of the classical language area, and the type of aphasia was
 complicated, while the recovery rate of language disorder was high during follow-up.
 Investigators hypothesized that the type of aphasia may be associated with the type of brain
 connectivity damaged, and that reorganization of brain connections and brain network promote
 the recovery of language function. In this study, we aim to investigate the types of aphasia
 and their corresponding brain network changes after the resection of BAVMs located in the
 Geschwind's territory. Investigators will evaluate language function and collect
 multimodality images of the patients before resection of the lesions, as well as 7 days, 3
 months and 6 months afterwards. In addition, the anatomical brain connectivity and brain
 network will also be analyzed. Our research will not only be a meaningful exploration for
 mechanisms of human language function damage and reorganization, but will also provide an
 important basis for the protection of brain function in neurosurgery.
Inclusion Criteria:

 1. Signed the informed consent form;

 2. The dominant hand is the right hand (evaluated by the Edinburgh hand scale);

 3. BAVM located in the left inferior parietal lobe

 4. No history of rupture and bleeding and neurosurgical treatment

 Exclusion Criteria:

 1. There are implants in the body (cardiac pacemaker, artificial femoral head, etc.);

 2. The dominant hand is unclear;

 3. Illiterate or other patients who can not cooperate well with cognitive function tests;

 4. The history of bleeding in BAVM patients within one month;

 5. History of neurosurgical treatment.