Cellulose Sulfate and HIV Transmission Among Women
Cellulose Sulfate and HIV Transmission Among Women
The purpose of the study is to determine the effect of cellulose sulfate on the transmission
 of HIV to women via vaginal intercourse. The secondary objectives are the effect on the
 transmission of gonorrhea and chlamydia via the same route.

 The study hypothesis is that there will be no effect.
Despite the availability of an effective HIV prevention method, i.e. the condom, the epidemic
 continues growing. There is thus an urgent need for additional HIV prevention methods. One of
 the possibilities is the use of microbicides, i.e. chemical products which may be used in the
 vagina or rectum with the potential to prevent HIV infection.

 Cellulose sulfate is an HIV entry inhibitor with an in vitro effect on N. gonorrhoeae (NG)
 and C. trachomatis (CT) and other sexually transmitted organisms.

 The study assess its effect on the vaginal transmission of HIV, NG and CT among women at high
 risk of heterosexual STI infection (defined as having had more than two partners in the last
 three months and an average of three sexual acts per week).

 The study is randomized, triple-blinded, placebo controlled.
Inclusion Criteria:

 -  at least 18 years old

 -  an average of at least three vaginal sex acts per week, at least three different
 partners in the last three months, expecting to continue this behavior

 -  HIV negative

 -  willing and able to comply with the protocol

 Exclusion Criteria:

 -  pregnancy

 -  allergy to latex or spermicides

 -  intravenous drug user