Persistence of Immune Response After Vaccination With Influenza Vaccine
Persistence of Immune Response After Vaccination With Influenza Vaccine
This clinical study will be performed in subjects aged 12-60 years old enrolled in
 NCT01310374 who received 2010 seasonal influenza vaccine to evaluate the persistence of the
 immune response of influenza vaccine up to 24 months after vaccination.
Subjects were previously vaccinated at 12 to 60 years of age with 2010 seasonal influenza
 vaccine.The persistence phase starts 24 months after the primary vaccination and blood
 samples will be taken at 6, 12, 18 and 24 months after primary vaccination. Subjects whose
 antibody titer less than 1:40 at 6 months after primary vaccination will receive a booster
 dose of influenza vaccine.
Inclusion Criteria:

 -  aged 12-60 years old

 -  male or non-pregnant female

 -  volunteers received 2010 seasonal influenza vaccine

 -  clinically healthy as determined by: medical history inquiring and physical
 examination

 -  provide written informed consents before joining the trial

 Exclusion Criteria:

 -  without history of 2010 seasonal influenza vaccine administration,

 -  allergic to any ingredient of vaccine,

 -  autoimmune disease or immunodeficiency,

 -  severe adverse reaction after vaccination, such as allergies, hives, breathing
 difficulties, angioedema or abdominal pain,

 -  severe acute and chronic diseases

 -  axillary temperature over 37.0℃ at the time of vaccination.