Prospective Randomized Study: Assessment of PRF Efficacy in Prevention of Jaw Osteonecrosis After Tooth Extraction
Prospective Randomized Study: Assessment of PRF Efficacy in Prevention of Jaw Osteonecrosis After Tooth Extraction
This prospective study will include patients taking or having taken bisphosphonates and
 needing dental extractions.

 The aim of this study is to validate the contribution of PRF (Platelet Rich Fibrin) in tooth
 extraction sites.

 In the test group (PRF) and in the control group (no PRF), we use the same atraumatic
 extraction protocol associated with the same antibiotic procedure.
Dental extractions are the main cause of jaw osteonecrosis in patients taking oral or iv
 bisphosphonates.

 This prospective randomized study will include a cohort of 100 patients treated with
 bisphosphonates (for benign or malignant conditions) and requiring dental extractions
 (non-retainable teeth for infectious, traumatic or parodontal reasons). 50 patients will
 benefit of PRF placement in the tooth extraction site (group 1) while 50 patients do not
 (group 2).

 The rest of the procedure will be the same in the 2 arms. In the literature, studies suggest
 a benefit from a long term antibiotherapy before and after tooth extraction. Extraction
 procedure should be the least traumatic as possible.

 The main objective of our study is to assess, after tooth extraction, the contribution of PRF
 in the prevention of jaw osteonecrosis induced by bisphosphonates.

 A follow-up period of one year after extraction is indicated.
Inclusion Criteria:

 -  patients taking bisphosphonates whatever the indication, the type, the administration
 and the duration of treatment (we include patients taking or having taken
 bisphosphonates, even several years ago)

 -  And who need tooth extraction (not recoverable in conservative dentistry and
 symptomatic tooth: dental and periodontal infections, symptomatic traumatic tooth
 fracture).

 Exclusion Criteria:

 -  pregnant women

 -  younger than 50 years old

 -  jaw's radiotherapy

 -  history of jaw osteonecrosis

 -  jaw metastasis from an other cancer