The Assessment of Copper Parameters in Wilson Disease Participants on Standard of Care Treatment
The Assessment of Copper Parameters in Wilson Disease Participants on Standard of Care Treatment
This was a 24-month study to assess copper parameters in participants with Wilson disease
 (WD) treated with standard of care (SoC) medications.

 After providing informed consent, participants meeting all inclusion and no exclusion
 criteria were enrolled into the study as outpatients. The participants' routine clinic visits
 were scheduled according to the standard clinical practice at the study center and at the
 discretion of the treating physician at approximate 6-month intervals.

 At the time of enrollment, participants were receiving SoC medications for the treatment of
 WD, which could include penicillamine, trientine, zinc, or a combination of a copper chelator
 and zinc. If treatment was interrupted or stopped during the course of the study,
 participants continued in the study and biological samples and clinical data were continued
 to be collected for the full 24-month study period. Dosing with SoC agents was individualized
 and managed by the treating physician at the study center according to standard clinical
 practice at the site.
Inclusion Criteria:

 -  Willing and able to give informed consent for participation in the study.

 -  Male or female participants, aged 18 years or older as of signing the informed consent
 form.

 -  Receiving SoC medications (penicillamine, trientine, zinc, or copper chelators with
 zinc) for the treatment of WD at the time of enrollment and for no more than 60 months
 prior to enrollment.

 -  Able to understand and willing to comply with study procedures and requirements, as
 judged by the Investigator.

 -  Established diagnosis of WD.

 -  Adequate venous access to allow for collection of blood samples.

 Exclusion Criteria:

 -  Major systemic disease or other illness that would, in the opinion of the
 Investigator, compromise participant safety or interfere with the collection or
 interpretation of study results.

 -  In the opinion of the Investigator, the participant was likely to be non-compliant or
 uncooperative during the study.