Thromboelastogram During Total Knee Replacement
Thromboelastogram During Total Knee Replacement
Verify the changes in coagulation system during total knee replacement surgery with
 tranexamic acid single bolus infusion.
The study was set to reveal changes in the coagulation and fibrinolytic systems during total
 knee surgery and especially during tourniquet placement, tourniquet removal and
 revascularization of ischemic limb, after tranexamic acid single bolus infusion, and at post
 operative day 1.
Inclusion Criteria:

 -  Osteoarthrosis

 -  TKR operation elective

 -  ASA I-III

 Exclusion Criteria:

 -  TKR due to any reason but osteoarthrosis

 -  known coagulation problems

 -  platelets < 100,000/DcL

 -  Hb < 12 g%

 -  past thrombo-embolic event

 -  treatment with aspiring during last week

 -  treatment with NSAID's during last 48 hours

 -  malignancy

 -  known allergy to tranexamic acid

 -  general anesthesia