Early Limb Rehabilitation Therapy Within 48 h of Acute Stroke Onset(ERTAS)
Early Limb Rehabilitation Therapy Within 48 h of Acute Stroke Onset(ERTAS)
This study aimed to evaluate effectiveness of initial limb rehabilitation compare therapy
 took place within 48h with therapy took place after 48h for patients with stroke (modified
 Rankin Scale Score 3-4).
Early rehabilitation after stroke is thought to contribute to the effects of stroke-unit
 care. However, time of initial rehabilitation therapy is poorly defined and not underpinned
 by strong evidence in patients with stroke (modified Rankin Scale Score 3-4). The
 investigators do this parallel-group, single-blind, randomized controlled trial in shengjing
 hospital of China Medical University. Participants (aged≥18 years) with ischaemic or
 haemorrhagic stroke, first or recurrent, who meet physiological criteria are randomly
 assigned (1:1), to receive usual stroke therapy. Treatment with recombinant tissue
 plasminogen activator is allowed. Randomisation is stratified by study site and stroke
 severity. The primary outcome was a outcome 3 months after stroke, defined as a modified
 Rankin Scale score of 3-4. The investigators do analysis on an intention-to-treat basis.
Inclusion Criteria:

 1. Patients were diagnosed acute stroke within 24h onset. Head CT or MRI scans were
 confirmed the diagnosed.

 2. The age was from 18 to 75 years old.

 3. Temperature ≤38.0℃，Pulse rate 60-100bpm，Respiratory rate≤24 bpm，systolic blood
 pressure≤220mmHg.

 4. Glasgow score: 9-14.

 5. Acute Physiology and Chronic Health Evaluation(APACHE Ⅱ)score: ≤17.

 6. National Institutes of Health Stroke Scale (NIHSS)score: <16. (Upper and lower
 extremity motor function item score<8).

 7. Modified Rankin Scale score:3-4.

 8. There were no serious diseases before, such as heart, liver, kidney and lung diseases.

 9. Patients themselves or their nominated representative sign the informed consent form.

 Exclusion Criteria:

 1. There were unstable vital sign. There were serious organic dysfunction (heart, liver,
 kidney or lung).

 2. Patients with transient ischemic attack.

 3. Patients with subarachnoid haemorrhage.

 4. Patients with haemorrhage were documented immediate surgery.

 5. Pregnancy patients with stroke.

 6. During the course of the project, major diseases took place (such as, myocardial
 infarction, gastrointestinal bleeding, respiratory failure, pulmonary embolism, deep
 vein thrombosis).