Efficacy of PTX+IFN Alpha+ RBV on Hepatitis C Virus Coinfected HIV Patients
Efficacy of PTX+IFN Alpha+ RBV on Hepatitis C Virus Coinfected HIV Patients
Current Hepatitis C virus (HCV) treatment consists of the combination of interferon alpha 2a
 (IFN-alpha 2a) plus ribavirin (RBV) and it provides sustained virologic responses (SVR) on 54
 to 56% on HCV monoinfected patients and this response is even lower on HIV-HCV coinfected
 patients. A previous study on HCV monoinfected patients showed that the addition of
 pentoxyfylline (PTX) to a treatment scheme based on interferon-alfa and ribavirin increased
 SVR on 25%, although it is not known if the same effect is to be obtained in HCV-HIV
 coinfected patients.

 On the other hand, other factors such as host genetics, have proved to influence treatment
 response on HCV infected patients. The best described genetic factor so far is the
 interleukin 28B (IL28B) polymorphism rs12979860, where a cytosine-cytosine (CC) genotype
 provides an almost twice increase on SVR than the rest of the genotypes.

 Therefore, this is a randomized, double blind study to assess the efficacy of pentoxyfylline
 addition to a treatment scheme based on interferon-alfa and ribavirin in chronic HCV genotype
 1, co-infected HIV-1 positive subjects, considering the IL28B polymorphism rs12979860.

 HIV-HCV coinfected subjects currently receiving Highly active antiretroviral therapy (HAART),
 with at least 8 months on undetectable HIV viral load and T helper cells count of 200 or
 higher will be included. Patients will be randomized on one of two groups:

 -  Group A: IFN alpha 2a + RBV + PTX

 -  Group B: IFN alpha 2a + RBV + placebo

 Patients will be followed for primary outcome during 72 (for rapid responders) or 96 weeks
 (for non rapid responses). Outcome measures will be the following:

 -  SVR rate 24 weeks after the end of treatment

 -  Grade of Hepatic fibrosis from baseline to the end of treatment, measured by transient
 elastography and the AST to platelet ratio index (APRI index)

 -  IL28B rs12979860 genotype

 The study hypothesis is that the addition of PTX to a treatment scheme based on IFN-alfa2a
 and RBV in chronic HCV genotype 1, co-infected HIV-1 positive subjects will improve SVR rate
 and fibrosis progression irrespectively of IL28B rs12979860 genotype.
Inclusion Criteria:

 -  HIV/HCV coinfected patients

 -  18 to 65 years old

 -  currently receiving HAART

 -  non-pregnant women

 -  HIV infection controlled as: undetectable viral load (<40 copies/mL) for at least 8
 months and T helper cells count of 200 cells/μL or above

 -  no contraindications to IFN alpha2a, RBV or PTX treatment

 -  sign informed consent form

 -  laboratory parameters within acceptable ranges

 Exclusion Criteria:

 -  Women that present a positive pregnancy test during the study

 -  Patients that for any reason no longer wish to receive IFN alpha2a, RBV or PTX
 treatment

 -  Serious adverse events that prevent to continue IFN alpha2a, RBV or PTX treatment;
 such as severe neutropenia, severe thrombocytopenia or severe anemia

 -  Presence of an opportunistic infection or malignancy that requires treatment with
 drugs interacting with IFN alpha2a, RBV or PTX

 -  Patients that fail to adhere to treatment