Effects of Proteins Fraction Derived From Milk on Osteoporosis Prevention
Effects of Proteins Fraction Derived From Milk on Osteoporosis Prevention
Osteoporosis is defined as a systemic skeletal disease characterised by low bone mass and
 microarchitectural deterioration of bone tissue, with a consequent increase in bone fragility
 and susceptibility to fracture. Osteoporosis is a serious public health problem that is
 responsible for approximately 3 million women with osteoporosis in France, with approximately
 150,000 cases per year occurring in vertebral fractures, of which only one third would be
 diagnosed and 50,000 hip fractures (causing death in 20% of cases). The frequency of the
 disease increases with age, particularly among women: 10% among women aged 60 years and 20%
 among women aged 65 and 40% among women aged 75. At menopause, oestrogen deficiency causes
 alterations of the immune system, decreased bone formation, microarchitectural deterioration
 and a decrease in bone mass. Various factors may contribute to this decrease in bone density
 such as diet, lifestyle, or the genetic background.

 According to prospective studies, an overexpression of 135% of hip fractures is expected at
 European level in 50 years. Therefore, it is interesting to develop new prevention approaches
 aimed at maintaining the healthy aging population. Nutritional researches can consider
 setting up a real prevention.

 Studies suggest that specific milk protein fraction contain factors able to promote bone
 formation, inhibit bone resorption in vitro. In animal model, they showed that the specific
 fraction prevents bone loss in aged ovariectomised rats by reducing bone resorption.
 Furthermore, in human volunteers, a supplementation with the specific milk protein fraction
 maintains balanced bone remodelling and increase bone mineral density. For example, in
 healthy postmenopausal women, it has been reported that a mean rate of gain of lumbar BMD in
 the MPF group (1.21%) was significantly higher than in placebo group (-0.66%; p<0.05).

 The objective of this study is to assess the efficacy of daily consumption of the milk
 proteins fraction on bone mineral density improvement in healthy postmenopausal women.
Inclusion Criteria:

 -  Caucasian Female

 -  Natural or surgical menopause between 1 and 5 years

 -  Aged between 50 to 65 years

 -  BMI between 19 and 30 kg/m²

 Exclusion Criteria:

 -  Medications: oral steroidal anti-inflammatory, anti-osteoporotic treatment, hormone
 replacement therapy

 -  Low bone mineral density (T-score<-3

 -  Diseases affecting bone metabolism(Paget's disease, Cushing's disease, thyroid
 disease...)

 -  Intolerance or allergy to milk proteins and allergy to soy or soy lecithin

 -  Heavy smoking

 -  Excessive alcohol drinking

 -  Intensive sports practice according to the investigator