Experimental Therapeutics in Essential Tremor Using Cerebellar Transcranial Direct Current Stimulation
Experimental Therapeutics in Essential Tremor Using Cerebellar Transcranial Direct Current Stimulation
The purpose of this study is to determine whether transcranial cathodal direct current
 stimulation (tDCS) delivered over the cerebellum can improve essential tremor.
Inclusion Criteria:

 -  Age ≥ 18 years and ≤ 65 years

 -  Important essential tremor (bilateral postural and/or action tremor since more than
 one year)

 -  Normal physical and neurological examination, except for essential tremor

 -  Insufficient efficiency of usual essential tremor's treatment

 -  No treatment altering the cortical excitability

 -  Agreement to use a medically acceptable method of contraception throughout the study
 for female of childbearing potential

 -  mini-mental status score >24

 Exclusion Criteria:

 -  Age < 18 years and > 65 years

 -  Current neurological or psychiatric illness other than essential tremor

 -  Individual who is on medication which is known to lower seizure threshold

 -  Previous history of seizure, loss of conciousness or current active epilepsy

 -  Contraindication for MRI or TMS study

 -  Intake of antiepileptic medications for essential tremor (barbiturates, gabapentine,
 topiramate, clonazepam), within the 7 days preceeding the first visit

 -  alcohol intake within the 24 hours preceeding the first visit

 -  Pregnancy, breast feeding women and women who are of childbearing age and not
 practicing adequate birth control

 -  Individual who have MMS ≤ 24/30 or patients legally protected or inability to provide
 an informed consent

 -  Simultaneous participation in another clinical trial

 -  Patients who are not enrolled at social security