A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Co-administration of ABT-493 and ABT-530 With and Without Ribavirin in Subjects With HCV Genotype 1, 4, 5, and 6 Infection
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Co-administration of ABT-493 and ABT-530 With and Without Ribavirin in Subjects With HCV Genotype 1, 4, 5, and 6 Infection
The purpose of this Phase 2, open-label, 2-part, multicenter study was to evaluate the
 efficacy, safety, and pharmacokinetics of co-administration of ABT-493 and ABT-530 with and
 without ribavirin (RBV) at different doses in chronic Hepatitis C virus (HCV) Genotype 1
 (GT1), Genotype 4 (GT4), Genotype 5 (GT5), and Genotype 6 (GT6) infection with compensated
 cirrhosis (GT1 only) or without cirrhosis (GT1, GT4, GT5, or GT6). Although RBV was initially
 planned in the protocol, it was not administered in any of the study arms.
This study consisted of two independent parts: Part 1 was conducted first followed by Part 2.
 Part 1 enrolled participants who received ABT-493 and ABT-530 for 12 weeks; Part 2 enrolled
 participants who received ABT-493 and ABT-530 for 8 or 12 weeks. Participants who completed
 or prematurely discontinued the treatment period were followed for 24 weeks to monitor HCV
 RNA to evaluate efficacy and the emergence and persistence of viral variants.
Inclusion Criteria:

 1. Male or female between 18 and 70 years of age, inclusive, at time of screening

 2. Screening laboratory result indicating hepatitis C virus (HCV) GT1 (Study Parts 1 and
 2) or GT4, GT5, or GT6 (Study Part 2) infection

 3. Chronic HCV infection defined as one of the following:

 -  Positive for anti-HCV antibody (Ab) or HCV RNA at least 6 months before
 screening, and positive for HCV RNA and anti-HCV Ab at the time of screening or

 -  Positive for anti-HCV Ab and HCV RNA at the time of screening with a liver biopsy
 consistent with chronic HCV infection (or a liver biopsy performed prior to
 enrollment with evidence of chronic HCV infection)

 4. Participant had to meet one of the following criteria:

 -  Treatment-naïve: participant had never received treatment for HCV infection

 -  Treatment-experienced: pegylated-interferon alpha-2a or alpha-2b and ribavirin
 (PR)-null responder (for Study Part 1) or PR-experienced (on-treatment failure or
 prior relapse) (for Study Part 2)

 5. Documented absence of cirrhosis (in Study Part 1 and in corresponding arms of Study
 Part 2), or compensated cirrhosis (in corresponding arms of Study Part 2, GT1 only),
 per local standard

 Exclusion Criteria:

 1. History of severe, life-threatening or other significant sensitivity to any drug

 2. Female who is pregnant, planning to become pregnant during the study or breastfeeding;
 or male whose partner is pregnant or planning to become pregnant during the study

 3. Recent (within 6 months prior to study drug administration) history of drug or alcohol
 abuse that could preclude adherence to the protocol in the opinion of the investigator

 4. Positive test result at Screening for hepatitis B surface antigen (HBsAg) or
 anti-human immunodeficiency virus antibody (HIV Ab)

 5. Hepatitis C virus (HCV) genotype performed during screening indicating co-infection
 with more than one HCV genotype

 6. Any cause of liver disease other than chronic HCV infection

 7. Participants with plasma HCV RNA load ≤ 10,000 international units (IU)/mL or
 unquantifiable or undetectable HCV RNA at screening

 8. Previous use of an HCV direct-acting antiviral agent (DAA)

 9. Consideration by the investigator, for any reason, that the participant was an
 unsuitable candidate to receive ABT-493, ABT-530, or RBV (RBV for cirrhotic subjects
 only)

 10. For participants in Study Part 2 who were enrolling with compensated cirrhosis: past
 clinical evidence of Child-Pugh B or C Classification (score of > 6) or clinical
 history of liver decompensation, including ascites (noted on physical exam), bleeding
 varices, use of beta-blockers for portal hypertension or ascites, or hepatic
 encephalopathy