Risk Factors of Incidence of Type 2 Diabetes and Cardiovascular Diseases---Shanghai Baoshan Study
Risk Factors of Incidence of Type 2 Diabetes and Cardiovascular Diseases---Shanghai Baoshan Study
Objective: Recruit 3 cohorts with 1000-1200 subjects each: people with normal glucose
 metabolism, impaired glucose regulation (IGR), and with Type 2 diabetes. To study the risk
 factors in development of type 2 diabetes.
Methods:

 We aim to perform a two-step blood glucose survey in 2008-2009 in a population selected from
 a single urban community of Shanghai. The Institutional Review Board of the Rui-Jin Hospital
 approved the study protocol. Informed consent will be obtained from each participant.

 1. In the first step, we first invited all registered permanent residents aged 40 or above
 by local poster advertisement and by mail to participate in a screening examination,
 during which we collected information on lifestyle, medical history and the use of
 medications using a questionnaire, and performed anthropometrical measurements and
 fasting glucose measurement. The first step of diabetes screening finished in June,
 2008.

 2. In the second step, after exclusion of subjects with self-reported diabetes, we
 classified the screened subjects into 3 groups according to their fasting plasma glucose
 concentration of 7.0 mmol/L or above, 5.0 to 6.9 mmol/L or below 5.0 mmol/L. We selected
 randomly a sample from these 3 subgroups for further investigation including a 75-g oral
 glucose tolerance test (OGTT) and blood and urine sampling and other vascular functional
 measurements. Our selection was based on a ratio of 1:1.2:1.44, because of the concern
 that by knowing the results of fasting plasma glucose test, subjects with lower glucose
 levels might have a lower participation rate than those with higher glucose
 concentrations. Nevertheless, this ratio was arbitrarily chosen. Finally, 1000 Type 2
 diabetic patients, 1200 subjects with IGR and 1440 subjects with normal glucose
 metabolism were selected as target population of this study by random sampling for
 further blood and urine sampling.

 3. Biomarkers and genetic risk factors will be evaluated in the study subjects.
Inclusion Criteria:

 -  aged above 40 years

 Exclusion Criteria: