Measuring Response to Depression Treatment
Measuring Response to Depression Treatment
The primary goal of this study is to compare a new symptoms rating questionnaire, called the
 Vancouver Semi-Structured Interview for Depression (V-SID), to the traditionally used
 questionnaires. The investigators predict that the V-SID will be more sensitive to patients'
 improvement than are traditional questionnaires.
Depression is sometimes associated with difficulties in thinking skills. Recent evidence
 suggests that in those people who have thinking difficulties, effective treatment and
 improvement of depression can also result in improved thinking skills. Therefore, a test of
 thinking skills is included in this study.

 This study will also evaluate three other potential indicators of treatment response:
 cortisol, cytokines, and grip strength.
Inclusion Criteria:

 -  Major depressive episode, diagnosed using the Mini-International Neuropsychiatric
 Interview (MINI)

 -  Depression not currently effectively treated

 -  Age 19 to 65 years

 Exclusion Criteria:

 -  Co-morbid Axis I disorders (co-morbid anxiety symptoms, including generalized anxiety
 or panic attacks, are not exclusionary if they are present in the context of a primary
 mood disorder)