Live Kidney Donor Study -Renal Function Study
Live Kidney Donor Study -Renal Function Study
Kidney transplantation from living donors has been shown to carry many benefits over deceased
 donor transplantation. Because of benefits such as shorter waiting times and improved outcome
 for transplant recipients, living kidney donation accounts for an increasing number of kidney
 transplants nationwide. Most published studies about living kidney donation demonstrate that
 the procedure is safe, but they also emphasize concerns that long-term data on live donor
 outcomes are insufficient. In particular, data concerning the extent of renal function
 decline after donation are inadequate. This study will measure glomerular filtration rate
 (GFR) in previous living donors and aims to more accurately describe renal function after
 kidney donation.
Previous studies poorly describe renal function after kidney donation. Most published studies
 of renal function after donation are based on predictive equations, which were not designed
 for living kidney donors. One concern is that use of these equations may underestimate
 glomerular filtration rate (GFR) following donation. Systematic underestimation of GFR may
 cause previous kidney donors to be inaccurately categorized as having chronic kidney disease
 (CKD).

 While data for the entire kidney donor population are insufficient, there is even less
 available information about renal function after donation in black renal donors. In the
 general population, the incidence of end stage renal disease is higher among blacks compared
 to whites. Whether this pattern carries over to the black renal donor population is unclear.

 The primary objectives of this study are to more accurately measure current GFR; evaluate the
 change in GFR before and after donation; compare measured GFR in donors matched by race, age,
 sex, time from donation, presence of hypertension, and presence of obesity; and evaluate
 differences between predictive equations and measured GFR.

 This is an observational study to look at the long term outcomes in living kidney donors.
 Participants in this study will also be participants in DAIT RELIVE-04. As a part of this
 study, participants will have a brief medical history taken and a glomerular filtration rate
 test performed.
Inclusion Criteria:

 -  Underwent unilateral donor nephrectomy between 5 and 50 years ago; but no later than
 June 30, 2005 at Mayo Clinic or University of Minnesota

 -  Alive at the time of study recruitment

 -  Underwent GFR measurement before and early after donor nephrectomy (Mayo Clinic
 participants only)

 -  Underwent GFR measurement late after donor nephrectomy and 3 or more years prior to
 the invitation to participate in this study (UMN participants only)

 -  Self reported black race (UAB participants only)

 -  Negative serum pregnancy test (Total Beta Human Chorionic Gonadotropin (HCG) <5) for
 women of child-bearing potential

 Exclusion Criteria:

 -  Less than 5 years out from time of kidney donation

 -  Inability to contact donor

 -  Inability or unwillingness to provide informed consent

 -  Iodine or iodinated contrast allergy.

 -  Pregnant or breast feeding women