Safety, Tolerability, and Pharmacokinetics of SAB-185 in Ambulatory Participants With COVID-19
Safety, Tolerability, and Pharmacokinetics of SAB-185 in Ambulatory Participants With COVID-19
: Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute
 respiratory syndrome coronavirus 2 (SARS-CoV-2). SAB Biotherapeutics has developed SAB-185,
 an Anti-SARS-CoV-2 Human Immunoglobulin Intravenous (transchromosomic [Tc] bovine-derived),
 as a potential therapeutic to treat COVID-19. This study will evaluate the safety,
 immunogenicity, and pharmacokinetics of SAB-185 in ambulatory participants with COVID-19.
Inclusion Criteria:

 Subjects must meet all of the following criteria for inclusion:

 1. 18-60 years of age

 2. Positive for presence of SARS-CoV-2 on NP or OP swab by FDA-authorized RT-PCR test
 within seven days prior to infusion

 3. At least one current symptom of COVID-19, onset within seven days prior to infusion:

 -  Fever or chills

 -  Cough

 -  Shortness of breath or difficulty breathing

 -  Fatigue

 -  Muscle or body aches

 -  Headache

 -  New loss of taste or smell

 -  Sore throat

 -  Congestion or runny nose

 -  Nausea or vomiting

 -  Diarrhea

 4. Able to understand the study and comply with all study procedures

 5. Agrees not to participate in any other trial of an investigational product during the
 study period

 6. Willing and able to provide written informed consent prior to the start of any study
 related activities

 7. If female, meets at least one of the following reproductive risk criteria

 -  Post-menopausal for at least 12 months

 -  Use of one or more of the following highly effective contraceptive methods for at
 least 90 days following the last dose of study product: combined estrogen and
 progestogen containing or progestogen-only hormonal contraception, intrauterine
 device (IUD), intrauterine hormone-releasing system, surgical bilateral tubal
 occlusion

 -  Vasectomized sole sexual partner who has received medical assessment of the
 surgical success

 8. Male and female subjects agree to sexual abstinence (refraining from heterosexual
 intercourse for at least 90 days following the last dose of study product) if not
 using birth control or condoms for males.

 Exclusion Criteria:

 Subjects who meet any of the criteria of severe or higher COVID-19 will be excluded from
 the study:

 -  Dyspnea at rest

 -  Respiratory rate > 30 breaths per minute

 -  SpO2 ≤ 93% on room air

 -  Heart rate ≥ 125 beats per minute

 -  Respiratory distress or respiratory failure.

 -  Evidence of critical illness

 1. Female subjects with positive pregnancy test, breastfeeding, or planning to
 become pregnant/breastfeed during the study period.

 2. Hospitalization or need for hospitalization for any cause

 3. Treatment or participation in another clinical trial of any other investigational
 agent within 30 days prior to enrollment.

 4. Use of other drugs that, in the opinion of the investigator, could complicate
 analysis of SAB-185.

 5. Subjects with the following risk factors:

 -  Compromised immune system including confirmed diagnosis of current cancer under
 treatment, inherited deficiencies of the immune system, immune suppressing medication,
 or other conditions causing leukopenia or neutropenia

 -  Known autoimmune condition requiring therapy more intensive than intermittent
 non-steroidal anti-inflammatories in the prior 6 months (for example: rheumatoid
 arthritis, lupus, inflammatory bowel disease)

 -  Chronic respiratory disease including COPD, emphysema, cystic fibrosis, pulmonary
 hypertension, or other chronic condition that requires the routine use of supplemental
 oxygen

 -  Chronic asthma requiring the use of oral steroids or hospitalization in the last six
 months

 -  Renal failure or renal insufficiency requiring dialysis

 -  Congestive heart failure or significant atherosclerotic disease (coronary artery
 disease or peripheral vascular disease) 6. Receipt of pooled immunoglobulin or plasma
 in past 30 days 7. Any other underlying medical (cardiac, liver, renal, neurological,
 respiratory) or psychiatric condition that in the view of the investigator would
 preclude use of SAB-185 8. Known IgA deficiency or previous allergic reaction to
 intravenous immunoglobin (IVIG)/subcutaneous immunoglobin (SCIG) 9. Positive for
 hepatitis B virus surface antigen, hepatitis C virus antibody, or HIV antibody by
 medical history 10. History of allergy, anaphylaxis, or severe reaction to beef
 products (including milk and gelatin).