Enhanced Liver Function in Non-alcoholic Obese Fatty Liver Patients by Low Level Laser Therapy
Enhanced Liver Function in Non-alcoholic Obese Fatty Liver Patients by Low Level Laser Therapy
Non-alcoholic fatty liver disease is excessive fat build-up in the liver with insulin
 resistance due to causes other than alcohol use.The obesity epidemic is closely associated
 with the rising prevalence and severity of nonalcoholic fatty liver disease.Currently, the
 only treatment modality for patients with fatty liver disease is weight loss and exercise
 which is challenging for most patients. Therefore, a huge need exists for an alternative
 approach to reducing alanine transaminase (ALT) & aspartate aminotransferase (AST) levels for
 these patients. Low level laser light therapy (LLLT) offers a simple, non-invasive, safe,
 effective and side-effect free alternative to achieving this goal, through LLLT's proven
 ability to effect weight loss, body circumference reduction and lipid profile modification
Non-alcoholic fatty liver disease (NAFLD) is a very common disorder and refers to a group of
 conditions where there is accumulation of excess fat in the liver of people who drink little
 or no alcohol. The most common form of NAFLD is a non serious condition called fatty liver.

 NAFLD is part of the metabolic syndrome characterized by diabetes, or pre-diabetes (insulin
 resistance), being overweight or obese, elevated blood lipids such as cholesterol and
 triglycerides, as well as high blood pressure. A few studies have suggested that weight loss
 may be associated with regression of fat within the liver. Therefore, the most important
 recommendations for people with fatty liver are to lose weight if they are overweight or
 obese, increase their physical activity, follow a balanced diet and unnecessary medications.

 Several studies have investigated low-level laser therapy (LLLT) or light-emitting diode
 (LED) therapy and have made advances in the understanding of the underlying mechanisms LLLT
 in biological systems. Few studies explain the effect of low level laser therapy on liver
 enzymes and non alcoholic fatty liver risk factors (as obesity).So, our goal was to perform a
 randomized controlled trial to investigate the effects of the LLLT on lipid profile, body
 weight and liver enzymes
Inclusion Criteria:

 -  • Sixty non-alcoholic fatty liver patients aged from 60-75 y

 -  Body mass index (BMI) ranged from 30 to 34.9 kg/m2

 -  Elevated triglyceride & LDL levels

 -  Higher Risk Waist Circumference Measurements (Men: 40 or more inches or 102
 centimeters or more/ Women: 35 or more inches or 89 centimeters or more)

 -  Elevated aminoalanine transaminase (ALT) level, defined as 20 or more
 Unites/Liter (U/L) above the normal gender-specific ALT levels: males: ALT ≥ 60
 U/L; females: ALT ≥ 50 U/L

 -  Review of subject's pre-existing medical records to confirm the current diagnosis
 of nonalcoholic fatty liver according to the following criteria:

 -  ALT elevated on two separate determinations

 -  Abdominal ultrasound showing fatty liver

 -  Blood work that excludes other potential etiologies of liver disease

 -  Subject agrees to maintain his or her diet regimen throughout study participation

 Exclusion Criteria:

 -  • History of cardiovascular disease or events including, but not limited to, coronary
 artery disease, valvular heart disease, cardiac arrhythmias, congestive heart failure,
 myocardial infarction, stroke, transient ischemic attack, or peripheral vascular
 disease

 -  Cardiac surgeries or procedures, including but not limited to, coronary artery
 bypass surgery or stent placement, heart transplantation, pacemaker insertion or
 implantation of a defibrillator

 -  An implanted device in the target area to receive low level laser light therapy
 (e.g. pain pump, lap band, penile inflation device, ventriculo-peritoneal shunts,
 etc.)

 -  Known photosensitivity disorder

 -  Current active cancer or within one year of cancer treatment or remission

 -  Excessive alcohol consumption defined as 14 or more alcoholic drinks per week

 -  Serious mental health illness that in the opinion of the investigator would
 preclude the subject from study participation

 -  Active infection, wound or other external trauma to the target area to receive
 the laser therapy

 -  Developmental disability or cognitive impairment that in the opinion of the
 investigator would preclude adequate comprehension of the informed consent form
 and/or ability to record the necessary study measurements

 -  Participation in a clinical study or other type of research in the past 30 days