Evaluation of Thyroid Function in Patients With Chronic Kidney Disease
Evaluation of Thyroid Function in Patients With Chronic Kidney Disease
A higher prevalence of thyroid disease has been associated with chronic kidney disease (CKD),
 and subclinical hypothyroidism seems to be the most common dysfunction. The aim is to
 evaluate thyroid function and autoimmunity in patients with CKD stages 3, 4 and 5.
 Cross-sectional study to be carried out on patients with stages 3 and 4 in a Nephrology
 outpatient clinic. Thyroid function is evaluated by measuring thyroid stimulating hormone
 (TSH), free thyroxine, free triiodothyronine and antithyroperoxidase antibodies (TPOAb)
 levels.
Cross-sectional study to be carried out on patients with stages 3, 4 and 5 in a Nephrology
 outpatient clinic. Thyroid function is evaluated by measuring thyroid stimulating hormone
 (TSH), free thyroxine, free triiodothyronine and antithyroperoxidase antibodies (TPOAb)
 levels. Free Thyroxine (FT4) will be measured by liquid chromatography tandem mass
 spectrometry and electrochemiluminescence immunoassay in order to compare methods in this
 population.

 The glomerular filtration rate was estimated (eGFR) by the Chronic Kidney Disease
 Epidemiology Collaboration formula (CKD-EPI), and the CKD stages were defined according to
 the Kidney Disease Improving Global Outcomes directives (KDIGO).
Inclusion Criteria:Patients over 18 years old with CKD stages 3 and 4 were included in the
 study.

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 Exclusion Criteria: 1) acute systemic inflammatory disease; 2) pituitary disease in the
 past or present; 3) regular treatment with amiodarone, lithium, interferon,
 immunosuppressive drugs and glucocorticoids; 4) previously diagnosed hypothyroidism and
 undergoing levothyroxine replacement.

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