Use of Antibiotic Irrigation to Decrease Wound Infections in Pediatric Perforated Appendicitis
Use of Antibiotic Irrigation to Decrease Wound Infections in Pediatric Perforated Appendicitis
The proposed study will investigate whether antibiotic irrigation using a
 gentamicin/clindamycin solution during laparoscopic appendectomy is superior in preventing
 postoperative wound infections and IAA in perforated appendicitis compared to suction without
 irrigation. This will be the first prospective study to compare these two options in
 pediatric PA.
This study is for pediatric patients who are having an appendectomy and have a perforated
 appendix. The purpose of this study is to see whether antibiotic irrigation using gentamicin,
 clindamycin and suction during the surgery works better when compared to suction alone when
 cleaning the stomach cavity.

 Arm A patients will have their abdomen irrigated with the antibiotics, gentamycin and
 clindamycin, and then the wound will be suctioned out. Arm B patients will not have the
 antibiotic irrigation but will have their wound suctioned.
Inclusion Criteria:

 1. Male or female, age 18 years or younger

 2. Scheduled to undergo laparoscopic appendectomy

 3. Preoperative or intra-operative diagnosis of perforated appendicitis (PA).

 4. Willingness to undergo treatments, provide written informed consent, and participate
 in follow-up.

 Exclusion Criteria:

 1. Male or female older than 18 years of age

 2. Declined to undergo laparoscopic appendectomy

 3. Not willing to provide written informed consent or undergo randomization of treatment

 4. Pregnancy