COPD in Obese Patients
COPD in Obese Patients
The study included 176 patients with COPD. The first group included 88 normal weight patients
 with COPD: 71 men and 17 women, mean age 62.40 ± 8.83 years. The second group included 88
 patients with COPD and obesity: 64 men and 24 women, mean age 62.94 ± 5.96 years. We assessed
 the frequency of COPD exacerbations in last 12 months, the severity of symptoms such as
 dyspnea, sputum production, fatigue. Spirometry, six-minute walk test and analysis of body
 tissue type composition were performed. BODE index was calculated. Levels of leptin,
 adiponectin, interleukins-4,6,8,10, interferon-γ, c-reactive protein (CRP), tumor necrosis
 factor receptor 1 (TNF-R1), tumor necrosis factor receptor 2 (TNF-R2), tumor necrosis factor
 alpha (TNF-α) were measured in blood serum.
Inclusion Criteria:

 -  COPD diagnosis, informed consent for voluntary participation in the study

 Exclusion Criteria:

 -  patient participation in any interventional study,

 -  COPD exacerbation,

 -  concomitant lung diseases, such as confirmed or suspected malignant lung disease or
 other respiratory disease, such as interstitial pulmonary fibrosis, tuberculosis,
 sarcoidosis, bronchial asthma, bronchiectasis,

 -  concomitant diseases of other organs and systems, such as acute cardiovascular
 diseases, chronic kidney diseases and liver failure.