Patient -Ventilator Interaction in Chronic Respiratory Failure
Patient -Ventilator Interaction in Chronic Respiratory Failure
To evaluate a novel advanced physiological monitoring system to improve nocturnal
 non-invasive ventilation (NIV) in Neuromuscular disease (NMD), Chest wall disease (CWD),
 Chronic Obstructive Pulmonary Disease (COPD) and Obesity Hypoventilation Syndrome (OHS)
 patients. By enhancing sleep comfort, adherence to ventilation will increase which, in turn,
 will improve ventilatory failure, quality of life and reduce length of admission during
 initiation of therapy. We aim to incorporate this technology into routine clinical practice.
Inclusion Criteria:

 1. Patients over the age of 16 years.

 2. Patients with confirmed diagnosis of Duchenne Muscular dystrophy or Chronic
 Obstructive Pulmonary Disease or Obesity Hypoventilation Syndrome.

 3. Patients with evidence of nocturnal hypoventilation with an arterial carbon dioxide
 partial pressure of >6.0 kPa in the morning.

 4. Patients with evidence of hypercapnic respiratory failure with an arterial carbon
 dioxide partial pressure of >6.0 kPa during the day.

 5. No prior domiciliary ventilation.

 Exclusion Criteria:

 1. Patients with other co-morbidities e.g. cancer or cardiac failure.

 2. Patients with muscular weakness but an unconfirmed diagnosis of Duchenne Muscular
 Dystrophy, Obesity Hypoventilation Syndrome or Chronic Obstructive Pulmonary Disease.

 3. Patients who have had an acute illness within the last 4 weeks prior to starting
 assessment for ventilation.

 4. Patients who have an abnormal bleeding tendency (INR or APTTr >1.4 or platelets <100).

 5. Patients with a psychological, social or geographical situation that would impair
 compliance with the project.