History of Hepatitis C in Volunteer Blood Donors
History of Hepatitis C in Volunteer Blood Donors
Hepatitis C is a disease of the liver caused by the Hepatitis C Virus (HCV). Patients with
 hepatitis C may feel well and show no signs or symptoms of being ill. However, researchers
 would like to study the long-term effects of this disease.

 Volunteer blood donors diagnosed with chronic hepatitis C viral (HCV) and various levels of
 liver enzyme activity will be offered a complete medical evaluation and liver biopsy. The
 tests will enable researchers to provide the patients with an idea of how severe their liver
 disease is. The virus and patient will be studied in order to understand why patients with
 hepatitis C develop different levels of liver damage.
A selected sample of volunteer blood donors with chronic hepatitis C viral (HCV) infection
 and various levels of serum aminotransferase activity will be offered a complete medical
 evaluation and liver biopsy to determine the severity of their liver disease. Various
 virological and host factors will be studied in an attempt to determine why patients with HCV
 infection develop differing degrees of liver disease.
Patients with chronic hepatitis C.

 Age 18 to 70 years, male or female.

 HCV infection indicated by the presence of anti-HCV (by ELISA and recombinant immunoblot
 assay [RIBA]).

 Written informed consent.

 Women must not be pregnant.

 Patients must not have significant systemic illnesses other than liver disease, including
 congestive heart failure, renal failure, uncontrolled diabetes mellitus.

 Patients must not have antiviral or immunosuppressive therapy within the last 6 months.

 Patients must not have HIV infection.

 Patients must not have contraindications to liver biopsy (mainly clotting abnormality
 (coumadin therapy, platelet count less than 50,000/cubic millimeter, prothrombin time more
 than 4 seconds beyond control)).