Effects of Heart Imaging Radiation on DNA Double-Stranded Breaks in Blood Lymphocytes and Hair Follicle Cells
Effects of Heart Imaging Radiation on DNA Double-Stranded Breaks in Blood Lymphocytes and Hair Follicle Cells
Purpose

 1. To investigate the effects of cardiac imaging radiation on the induction of DNA
 double-strand breaks by enumerating gamma-H2AX foci in blood lymphocytes and plucked
 hair follicle cells.

 2. To estimate whether the use of breast shields in cardiac computed tomographic
 angiography (CCTA) limits the effective radiation exposure of breast tissue.
The primary objective of the study is to analyze blood and hair samples from patients
 undergoing cardiac imaging to estimate radiation exposure levels as well as their biological
 effects (i.e. to determine the degree of genotoxicity by measuring the amounts of DNA
 double-strand breaks).

 The secondary objective is to investigate whether the use of in-plane breast shielding in
 female patients undergoing CT angiography (CCTA) limits the radiation exposure of breast
 tissue and subsequent DNA damage in blood lymphocytes and hair follicle cells.
Inclusion Criteria:

 -  Adult male and female adult subjects (age greater than 18 years)

 -  Referred for cardiac computed tomography angiography (CCTA), myocardial perfusion
 scintigraphy (MPS), or diagnostic invasive coronary angiography (ICA).

 Exclusion Criteria:

 -  Female patients that identify themselves as pregnant or have a positive pregnancy test
 prior to cardiac imaging.

 -  History (present or past) of leukemia or lymphoma.

 -  History of radiation therapy

 -  X-ray examination or scintigraphy within the last 72 hours.

 -  History of coronary revascularization (coronary artery bypass grafting or percutaneous
 coronary intervention)

 -  Patients undergoing percutaneous coronary intervention at completion of diagnostic
 left heart catheterization