Comparison of the Efficacy of Intravenous Paracetamol and Ibuprofen in the Treatment of Fever Due to Upper Respiratory Tract Infection
Comparison of the Efficacy of Intravenous Paracetamol and Ibuprofen in the Treatment of Fever Due to Upper Respiratory Tract Infection
Currently, paracetamol, ibuprofen and nonsteroidal antiinflammatory drugs are widely used by
 emergency physicians in Turkey for the treatment of fever . The objective of the study is
 compare the efficacy of intravenous ibuprofen and paracetamol in the treatment of patients
 with upper respiratory tract infections presenting with fever in the emergency department
This is the randomized double blinded clinical trial to compare the efficacy of these two
 drugs in this clinical setting. A randomized clinical trial was conducted in the Emergency
 Department (ED) of Pamukkale University Medical Faculty Hospital Study personnel (emergency
 physicians and emergency service nurses) were trained before the study. When intravenous
 drugs (Paracetamol and İbuprofen) was being recommended, an eligibility checklist was
 completed by the attending physician. patients who presented to the emergency department with
 upper respiratory tract infection and had a temperature above 38.0 ° C were measured by a
 fever gauge included into the study First Group: 1000 mg of paracetamol ( parol 10mg/ml
 solution Mefar, Turkey) intravenous (IV) was given 100 patients

 Second Group:

 Ibuprofen 400 mg ( intrafen 400mg/4ml solution -Gen ilaç san., Turkey) intravenous (IV) was
 given 100 patients which determined to be applied as a group. Drug packs prepared in 150 ml
 serum physiology were numbered by an independent nurse, who not involved in the study
 Randomization was achieved by using computer software to generate random numbers. During the
 intervention, participants were monitored by an oxygen saturation (SpO2) monitor, an
 automatic sphygmomanometer (blood pressure), and a rhythm monitor (heart rate and rhythms).
 Patients in both groups received two types of medication in a similarmanner, thus ensuring
 double blind.
Inclusion Criteria:

 -  Patients who have fever for less than five days

 -  At least 1 upper respiratory tract infection (URTI) symptom according URTI questionare

 Exclusion Criteria:

 -  Patients use anti-pyretic last 4 hours

 -  To be Pregnancy and breast-feeding Patients of childbearing age who are not using a
 birth control method

 -  Patients with an allergy trait (paracetamol and Ibuprofen) Illiterates

 -  Hemodynamically unstable patients

 -  Patients with renal transplantation

 -  Patients with glucose 6 phosphate dehydrogenase (G6PD) deficiency

 -  Patients with non-controlled hypertension

 -  Patients with a history of cerebrovascular disease

 -  Patients with severe liver, kidney,pulmonary and cardiac heart failure

 -  Patients use antibiotics last 7 days

 -  Patients with Wolff-Parkinson-White syndrome or accompanying arrhythmias associated
 with conductive stimulus delivery in the heart

 -  Patients with vision problems