Protocol: Mental Practice Combined With Physical Practice of Gait in Parkinson's Disease.
Protocol: Mental Practice Combined With Physical Practice of Gait in Parkinson's Disease.
Among the impairments associated with Parkinson's disease (PD), gait disturbance is one of
 the most injurious to the independence in daily living activities and the quality of life of
 people living with Parkinson's disease (PPD). Despite a considerable amount of research,
 there is no consensus about the most efficient physiotherapeutic approach to improve gait
 disturbance. Mental practice (MP) is considered an efficient strategy to improve the motor
 performance of healthy individuals and people with stroke. However, there is little evidence
 about its therapeutic results as a tool to improve gait performance in PPD. Thus, the aim of
 this study is to investigate the effects of mental gait practice associated with physical
 practice (PP) to improve the gait performance of PPD.
Background: Among the impairments associated with Parkinson's disease (PD), gait disturbance
 is one of the most injurious to the independence in daily living activities and the quality
 of life of people living with Parkinson's disease (PPD). Despite a considerable amount of
 research, there is no consensus about the most efficient physiotherapeutic approach to
 improve gait disturbance. Mental practice (MP) is considered an efficient strategy to improve
 the motor performance of healthy individuals and people with stroke. However, there is little
 evidence about its therapeutic results as a tool to improve gait performance in PPD.

 Objectives: To investigate the effects of mental gait practice associated with physical
 practice to improve the gait performance of people living with Parkinson's Disease.

 Design: Parallel, prospective, double-blind, multicentre randomized clinical trial.

 Setting: Brazilian Parkinson Association.

 Participants: Onde hundred and forty four people living with Parkinson's disease in stages
 2-3 disease evolution according to Hoehn and Yahr Classification.

 Interventions: The participants will be randomly allocated in an experimental group (EG), and
 a control group (CG). Both groups will perform 10 individual training sessions, two
 individual sessions per week, for five weeks. Every session will be guided by a
 physiotherapist. The training sessions consist of four blocks of MP intercalated with four
 blocks of PP of gait in single-task (ST) and dual-task (DT) conditions. The only difference
 between the groups will be the content of mental practice blocks: the EG will perform mental
 practice of gait (GMP) while the CG will perform non-gait mental practice (nGMP).

 Randomization: Participants will be randomized by ClinStat software into one of two groups:
 Experimental Group (EG), which will perform the GMP; and Control Group (CG), which will
 perform the nGMP.

 Statistical analysis: The training effects for each primary and secondary outcome measure
 will be analyzed for the two training conditions (i.e., control and experimental) at the four
 assessment time points (i.e., 7 days pre-intervention and post-completion, and at 30 and
 60-day follow-up) using a mixed-design ANOVA with training as the between-group factor and
 the assessment time point as the within-group factor. The effect sizes (ES) will be
 calculated for all comparisons at alpha = 0.05. A Tukey HSD post-hoc test will be used for
 multiple comparisons and p-values below 5 % will be considered as statistically significant.
Inclusion Criteria:

 -  diagnosis of Parkinson's disease according to the United Kingdom Brain Bank criteria;

 -  in stage 2-3 of the disease evolution according to the Hoehn and Yahr;

 -  treated with levodopa or its synergists;

 -  capable to walk independently indoors without aid;

 -  referring 5 years of education or more.

 Exclusion Criteria:

 -  presence of other neurological (excluding PD), orthopedic or cardiopulmonary problems;

 -  visual and auditory deficiency uncorrected;

 -  dementia [assessed by Montreal Cognitive Assessment (MoCA), cut-off 26];

 -  depression [according to the Geriatric Depression Scale (GDS-15), cut-off 6];

 -  declined imagery capacity [according to the Revised Movement Imagery Questionnaire
 (MIQ-R) cut-off 10].