Transurethral Ventral Wall of Urethra-preserving Enucleation of Prostate
Transurethral Ventral Wall of Urethra-preserving Enucleation of Prostate
In this study, the investigators designed a randomized and double-blind prospective trial to
 evaluate the efficiency and safety of the investigators new approach-transurethral ventral
 wall of urethra-preserving enucleation of prostate in comparison with TURP for the
 hyperplasia weighing more than 45 g.
Although in recent dozen of years, laser operation and other safer minimally invasive
 surgeries have been well-developed, transurethral resection of the prostate (TURP) is still
 the gold standard for the surgical treatment of benign prostatic hyperplasia, despite of its
 various complications, and not suitable for the hyperplasia over 80 g which should be
 resected under open surgery. In this study, we design a randomized and double-blind
 prospective trial to evaluate the efficiency and safety of our new approach-transurethral
 ventral wall of urethra-preserving enucleation of prostate in comparison with TURP for the
 hyperplasia weighing more than 45 g.Urodynamic examination [maximum flow rate (QMax),
 detrusor pressure, and so on], transrectal color Doppler ultrasonography for the prostate,
 blood routine, blood electrolyte, prostate specific antigen (PSA), International Prostate
 Symptom Score (IPSS), the quality of life (Qol), blood loss during operation, and the weight
 of resected prostate were studied before and after the operation.
Inclusion Criteria:

 -  BPH was diagnosed by DRE, Ultrasonography, CT or MR

 -  IPSS:>15

 -  Qmax:≤10ml/s and volume of bladder >200ml

 -  The weight of prostate >45g

 Exclusion Criteria:

 -  Patient with other aggravating malignant tumor

 -  Total-PSA>20ng/ml, or 4<total-PSA<20ng/ml but the value of Free-PSA/total-PSA<0.16

 -  The maximum press of detrusor muscle <15cmH2O

 -  Patient with urethral stricture

 -  Patient with urinary infection

 -  Patient with Nervous System Disease

 -  Patient with surgical contraindication, such as severe cardiac or lung disease,
 diaphragmatic hernias, and so on