Myo-inositol Versus Clomiphene Citrate in PCOS
Myo-inositol Versus Clomiphene Citrate in PCOS
Specific aim: To compare inositol and the golden standard first line treatment of ovulation
 induction, namely clomiphene citrate.
Inclusion Criteria:

 -  Rotterdam criteria for PCOS (cf. the recent ESHRE guidelines): at least 2 out of 3
 criteria should be fulfilled: irregular cycle (shorter than 21 days or longer than 35
 days); clinical (modified Ferriman-Gallwey score ≥ 6) or biochemical signs (elevated
 free testosterone) of hyperandrogenism (www.eshre.eu/Guidelines-and-
 Legal/Guidelines/Polycystic-Ovary-Syndrome.aspx); PCO ovaries on ultrasound
 (www.eshre.eu/Guidelines-and- Legal/Guidelines/Polycystic-Ovary-Syndrome.aspx):
 multiple small cysts (≥ 20 per ovary and/or an ovarian volume ≥ 10 ml, measured with a
 probe >8 MHz) in both ovaries.

 -  A first treatment cycle, possibly combined with intra uterine insemination (IUI) and
 this for (one of) the following reasons: mild male factor (as defined by each local
 center) endometriosis AFS score 1 or 2

 -  Use of own or donor sperm.

 Exclusion Criteria:

 -  Tubal factors

 -  Uterine factors

 -  Endometriosis AFS score 3 or 4

 -  Moderate to severe male factor (as defined by each local center)

 -  BMI > 35