Reperfusion With Cooling in Cerebral Acute Ischemia
Reperfusion With Cooling in Cerebral Acute Ischemia
The purpose of this study is to determine whether reducing a patients body temperature (mild
 hypothermia of 33 degrees Centigrade) will significantly reduce the risk of brain injury
 (notably reperfusion injury and hemorrhagic conversion) in patients that have suffered a
 significant interruption of blood flow to an area of brain (occlusion of large proximal
 cerebral artery) and have undergone successful removal of that interruption
 (revascularization).
Inclusion Criteria:

 -  Age 18-85 years old

 -  Symptoms consistent with an ischemic stroke with a large vessel occlusion (MCA,
 ICA-terminus) as determined by vascular imaging

 -  ASPECTS score of 5-7 on non-contrast CT of the brain

 -  Ability to undergo endovascular reperfusion therapy

 -  Must have no contraindications to general anesthesia

 -  A pre-treatment modified Rankin Score of 0 or 1

 -  Arterial puncture performed under 8 hours from symptom onset or last seen normal

 -  Immediate post reperfusion CT scan shows no hemorrhage

 Exclusion Criteria:

 -  Bleeding diathesis with a platelet count < 50,000 or INR > 1.5

 -  Involved in another clinical trial

 -  History of dementia

 -  End stage renal disease on hemodialysis

 -  History of ventricular dysrhythmias

 -  Life threatening medical condition precluding survival under 6 months

 -  Presence of an IVC filter

 -  Contrast dye allergy with history of anaphylaxis