Beneficial Effects of Grape Seed Proanthocyanidin Extrat on Progression of Atherosclerotic Plaques in Clinical Use
Beneficial Effects of Grape Seed Proanthocyanidin Extrat on Progression of Atherosclerotic Plaques in Clinical Use
The purpose of this study is to investigate the antiatherogenic effect of GSPE in clinical
 use
Atherosclerotic plaques indicate the occurrence of ischemia events and how to deal with it is
 a difficult task for clinical physicians. Grape seed proanthocyanidin extrat (GSPE) has been
 reported to exert an antiatherogenic effect by inducing regression of atherosclerotic plaques
 in animal experimental studies. In this study, the antiatherogenic effect of GSPE has been
 investigated in clinical use.
Inclusion Criteria:

 -  (1) carotid ultrasound examination: presence of carotid plaque or abnormal CIMT of
 between 0.9 and 1.2mm; (2) lipid profile: LDL≦3.12mmol/L, TC≦5.2mmol/L; (3) no
 lipid-lowering treatment within the past 6 months.

 Exclusion Criteria:

 -  severe cardiomyopathy, acute coronary syndrome, hepatic dysfunction, end-stage renal
 failure (serum creatinine ≥117mmol/L), prior carotid endarterectomy, and/or patients
 who did not agree to participate in the present study.