Intensive Insulin for Severe/Moderate Hypertriglyceridemia Pancreatitis.
Intensive Insulin for Severe/Moderate Hypertriglyceridemia Pancreatitis.
The aim of this study is to investigate the therapeutic efficacy of intensive insulin in
 patients with hypertriglyceridemia induced moderate/severe acute pancreatitis on the course
 and outcome of disease.
Hypertriglyceridemia-induced acute pancreatitis occurs in about 1-4% of the cases. It is the
 third leading cause of pancreatitis after biliary and alcoholic etiology.
 Hypertriglyceridemia can be caused by primary causes, lipid metabolism disorders and
 secondary causes.

 Hyperlipidemic pancreatitis can be provoked when triglyceride levels (TGL) exceed 11.3 mmol/l
 (1,000 mg/dl). Except for standard symptomatic treatment, plasmapheresis and insulin have
 been performed to rapidly reduce TGL and chylomicron levels in the blood.The therapeutic
 efficacy of intensive insulin, standard insulin, and plasmapheresis in patients with
 hypertriglyceridemia induced moderate/severe acute pancreatitis on the course and outcome of
 disease.After acceptance patients will be randomized by random envelope in the 3 groups:
 Group A: intensive insulin (glycemic control 4.4-6.1mmol/L), Group B: standard insulin
 (glycemic control 7.8-10.0 mmol/L), and Group C: plasmapheresis.
Inclusion Criteria:

 -  Diagnosis of hypertriglyceridemia induced acute pancreatitis (AP): Typical pain
 increase in serum lipase or amylase with serum TG> 1,000 mg/dL (11.3mmol/L) or serum
 was milky with serum TG> 500 mg/dL(5.65 mmol/L)

 -  Onset of abdominal pain within <=48h before admission

 -  moderate severe or severe Acute Pancreatitis according to Atlanta criteria

 -  except for other AP causes, such as cholelithiasis, alcohol, drugs and so on

 Exclusion Criteria:

 -  other etiologies other than hyperlipidemia leading to AP

 -  at the same time combined with other etiologies of AP

 -  appear difficult to reverse respiratory failure, severe systemic circulatory failure,
 coma and other the endangered symptoms, patients expected to die within 24hours

 -  disseminated intravascular coagulation, or patients with severe active bleeding

 -  without informed consent, the patient refused to plasma replacement, and other
 circumstances may bring significant bias.