The Additive Anti-inflammatory Effect of Simvastatin in Combination With Inhaled Corticosteroids in Asthma
The Additive Anti-inflammatory Effect of Simvastatin in Combination With Inhaled Corticosteroids in Asthma
We hypothesize that simvastatin in combination with ICS might have synergistic
 anti-inflammatory effects on airway inflammation in asthmatic patients
To determine the additive effect of simvastatin on airway inflammation in ICS-treated
 patients with persistent asthma by measuring eosinophil counts in induced sputum
Inclusion Criteria:

 -  He or she has FEV1 > 60% of predicted

 -  He or she requires less than 1000 mcg daily of beclomethasone or equivalent

 Exclusion Criteria:

 -  He or she had previous history of renal disease or serum creatinine more than 2 mg/dL

 -  He or she had previous history of liver disease

 -  She is pregnant or during lactation

 -  He or she has already received statins or is allergic to statins or has developed
 myositis.

 -  He or she has an asthma exacerbation and requires treatment with oral corticosteroids
 during the 3 months prior to the commencement of study entry.