Tiotropium Induced Bronchodilation in Lung CT Scored Emphysema
Tiotropium Induced Bronchodilation in Lung CT Scored Emphysema
To evaluate if tiotropium (Spiriva)induced bronchodilation of inspiratory capacity in
 patients with moderate to severe copd subjected to metronome paced hyperventilation induced
 dynamic hyperinflation is dependent upon the extent of underlying emphysema as determined by
 high resolution-thin section CT lung.
We will analyze post hoc, data that was previously published: Gelb AF et al.Chest
 2006;131:690-695. We have shown that tiotropium increases resting inspiratory capacity
 thereby providing lung volume protection against metronome paced hyperventilation induced
 dynamic hyperinflation. End point will be to correlate increase in tiotropium induced FEV
 1(L) and inspiratory capacity with extent of underlying emphysema as scored by lung CT ( Gelb
 AF et al:Chest 1996; 109: 353-359)in 29 patients with COPD. We will also correlate the
 decrease in inspiratory capacity following metronome paced hyperventilation induced dynamic
 hyperinflation with extent of lung CT scored emphysema.
Inclusion Criteria

 -  moderate to severe copd

 Exclusion Criteria

 -  unable to tolerate tiotropium

 -  unable to perform metronome paced hyperventilation induced dynamic hyperinflation