Prospective Evaluation of Patients With Uterine Cervical Cancer in Brazilian Health Institutions - The EVITA I Study
Prospective Evaluation of Patients With Uterine Cervical Cancer in Brazilian Health Institutions - The EVITA I Study
The primary objective of this study is to describe the socio-demographic, clinical
 pathological, quality of life and treatment characteristics of patients diagnosed with CC in
 Brazil.
The primary objective of this study is to describe the socio-demographic, clinical
 pathological, quality of life and treatment characteristics of patients diagnosed with cervix
 cancer (CC) in Brazil. Other specific objectives are:

 -  To describe socio-demographic characteristics: age at diagnosis, education, family
 income, race, occupation, personal health habits - e.g.oral contraceptive use ever/never
 and duration; smoking never/ever/current/duration , ever drinking), sexual history,
 insurance coverage (private, public), institution (private, public, philanthropic),
 obstetric history, comorbidities, performance status, human papillomavirus vaccination
 or not

 -  To describe the screening for CC: access, type, frequency and results.

 -  To describe clinical pathological characteristics of CC: histology (adeno x squamous x
 adenosquamous x neuroendocrine x other) , International Federation of Gynecology and
 Obstetrics (FIGO) stage, pathological stage, exams for staging, date of diagnosis, site
 of metastasis.

 -  To describe treatment characteristics of CC: date of surgery, type of surgery; date and
 duration of radiotherapy, type of radiotherapy; date, type and lines of systemic therapy
 (chemotherapy, monoclonal antibodies),

 -  To describe treatment safety (grade 3-4 AEs, death due to treatment toxicity,
 discontinuation due to AE). In addition adverse events of special interest will be
 described (details on Safety section).

 -  To describe the outcomes: follow-up exams and date of visits, persistent disease,
 recurrence, progression times in metastatic disease, complications (e.g.
 hydronephrosis/nephrostomy/ GI perforations and both GI & genitourinary fistulae.),
 death due CC and death from any cause.
Inclusion Criteria:

 -  Histologic confirmed invasive cervical cancer

 -  Diagnosis of FIGO stages

 -  Stage 1B to 2A high risk

 -  2B-4B or recurrent disease

 -  Patients ≥18 years old

 Exclusion Criteria:

 1. Non-invasive uterine carcinoma;

 2. Pregnancy;

 3. synchronous tumor or second primary tumor in the past 5 years (except thyreoid ancer
 or non-melanoma skin cancer).