Central Hypothyroidism and Cardiovascular Risk
Central Hypothyroidism and Cardiovascular Risk
Retrospective trial of 300 patients with pituitary insufficiency treated in Department of
 Medica Endocrinology, Rigshospitalet, Copenhagen University concerning levothyroxine (T4)
 replacement and cardiovascular risk factors. The hypothesis is that subtle central
 hypothyroidism is associated with adverse cardiac risk factors, such as body composition and
 serum lipids, and that improved T4 replacement will eliminate this increased risk,
 independently of other pituitary hormone replacements.
Retrospective trial of 300 patients with pituitary insufficiency treated in Department of
 Medical Endocrinology, Rigshospitalet, Copenhagen University concerning levothyroxine (T4)
 replacement and cardiovascular risk profile. The patient files are recruited among
 hypopituitary patients treated with growth hormone from the period 1993 to 2008. The trial is
 a retrospective assessment of data already collected for routine purposes and thus an audit
 of daily clinical practice. All information on the patients is obtained from the paper and
 electronic files existing in the department and no new measurements are foreseen.
Inclusion Criteria:

 -  All patients with pituitary hypopituitarism

 Exclusion Criteria:

 -  Unavailability of data