Comparing 2 Types of Pain Relief After Cesarean Delivery: Spinal Morphine and TAP Block
Comparing 2 Types of Pain Relief After Cesarean Delivery: Spinal Morphine and TAP Block
Summary Brief Summary Standard care for pain relief after cesarean delivery is spinal
 morphine. Spinal morphine may be unsuitable for patients having general anesthetic or prior
 morphine-related side effects and can be less effective in patients with morphine tolerance.
 An alternative is a TAP block where local anesthetic is deposited between the abdominal
 muscles consequently numbing the area and providing pain relief. The investigators believe a
 TAP block will provide equivalent pain relief to spinal morphine.
Detailed Description In North America, the standard of care is neuraxial morphine. This is an
 effective analgesic, but can still cause problems with nausea, vomiting and itching. Spinal
 morphine may be unsuitable for patients who have had morphine-related side effects in the
 past and can be less effective in patients with morphine tolerance. It is also poorly suited
 for patients who have had a general anesthetic, as anesthesiologists do not routinely access
 the spinal space purely for analgesia. It is only when they are using the spinal route for
 surgical anesthesia, that they will also deposit morphine to provide pain relief after
 surgery.

 The abdominal wall incision is an important contributor to pain following a cesarean
 delivery. The nerves supplying the anterior abdominal wall between the internal oblique and
 transversus abdominis muscles. By depositing local anesthetic solution between these muscles
 on each side, it is possible to block all these nerves and provide analgesia for the incision
 of the anterior abdominal wall. This is known as the transversus abdominis plane block or TAP
 block.

 Studies have shown the TAP block to be useful for midline laparotomies for open
 prostatectomies, bowel resection and as rescue analgesia for abdominal surgery. There are two
 studies which look specifically at TAP block after cesarean delivery but none of them have
 compared it directly the current standard.

 This study is a direct comparison of spinal morphine and TAP block. Obviously, adequate
 analgesia is of paramount importance to the patient and those caring for her. Studies to date
 indicate that the TAP block provides similar analgesia to spinal morphine in the early
 post-operative period. Therefore it would be a reasonable alternative for those patients who
 cannot have spinal morphine or who can not tolerate spinal morphine due to its side effects.

 The primary objective will be to investigate whether the tranversus abdominis plane block
 provides equivalent analgesia post-cesarean delivery, as intrathecal morphine.

 The secondary objective will be to determine whether there is a difference in post-operative
 abdominal scar pain, at three months post-surgery.

 This study will be a prospective, randomized, placebo-controlled, double blinded study.

 The study will involve two groups. Both groups will have spinal anesthesia for the surgery
 provided with 9-12 mg heavy bupivacaine and 10 mcg fentanyl.

 1. Control group: standard care plus a placebo block.

 2. Intervention group: no additional spinal medications will be given and an
 ultrasound-guided TAP Block will be given instead of the standard intrathecal morphine.

 Standard post-cesarean analgesia and PONV orders will be resumed post-delivery.
Inclusion Criteria:

 -  Elective cesarean delivery under spinal anesthesia patients.

 -  >28 weeks gestation

 -  ASA 1 and 2 classification of health

 -  Mothers presenting to the assessment unit with ruptured membranes or in early stages
 of labour for whom a vaginal birth was not planned and who are therefore in need of
 urgent cesarean delivery.

 -  Able to read and understand English,

 -  Only patients expected to deliver before midday will be approached for participation
 in the trial to facilitate post-operative data collection.

 Exclusion Criteria:

 -  Mothers in active labour

 -  ASA classification 3 or above

 -  Emergency cesarean delivery for fetal heart rate abnormalities

 -  Cesarean delivery under general anesthesia

 -  Maternal age <19

 -  BMI >40.

 -  Cesarean deliveries where a CSE is planned.

 -  Mothers with a history of drug allergy to morphine or to local anesthetics

 -  Mothers who are likely to deviate from standard postpartum analgesia protocol because
 of history of morphine tolerance or sensitivity.