Retrospective Study of the Relationship Between Human Papillomavirus Genotype and Cervical Epithelial Lesions
Retrospective Study of the Relationship Between Human Papillomavirus Genotype and Cervical Epithelial Lesions
Human papillomavirus (HPV) infection plays a key role in the carcinogenesis of cervical
 cancer and pre-invasive lesions. There are hundred types of HPV, including high risk and low
 risk types, and it is proved the close association between the cervical cancer and high risk
 HPV. While HPV 16 and 18 are known to be the leading two genotypes detected in women with
 cervical neoplasm worldwide, there is considerable difference in the other prevalent high
 risk genotypes in different geographic areas. It is important to establish the local database
 about the cervical intraepithelial lesions and the related prevalent HPV genotypes. The
 investigators designed a retrospective study which included total 784 patients managed at our
 hospital from January 1, 2000 to December 31, 2007. The present study was to investigate the
 HPV genotypes in the Taiwanese female patients with abnormal cervical cytology and analyses
 the association between HPV types and cervical pre-invasive lesions. It could provide the
 guide for the clinicians in the management of patients with abnormal cytological change of
 Pap smear.
Inclusion Criteria:

 -  Healthy volunteers

 -  People infected with HPV type 16 but without CIN lesions

 -  Patients with CIN lesions

 -  Patients with cervical cancer from National Taiwan University Hospital

 -  Informed consent is obtained, and the protocols are reviewed and approved by the
 appropriate Investigative Review Boards.

 Exclusion Criteria:

 -  None