Efficacy and Safety of Rivaroxaban in Acute Non-neoplastic Portal Vein Thrombosis in HCV
Efficacy and Safety of Rivaroxaban in Acute Non-neoplastic Portal Vein Thrombosis in HCV
Portal vein thrombosis (PVT) in patients with liver cirrhosis may be due to neoplastic growth
 or non-neoplastic causes.

 -  Treating PVT with anticoagulation in liver cirrhosis is difficult to be established but
 may be of great benefit in acute symptomatic PVT.

 -  The ultimate goal is complete recanalization of the portal vein without inducing major
 bleeding, abnormal liver function tests or increased mortality.
Out of 220 patients with chronic HCV who had undergone splenectomy due to hypersplenism in
 the period extending from May 2014 until August 2016; 36 participants (16.4%) were selected.
 They were presented with acute PVT. Also, the investigators enrolled 4 patients who were
 presented with PVT due to portal pyemia complicated infected thrombosed internal piles (n=1),
 appendicular abscess (n=1), ulcerative colitis (n=2).

 Control group It included 30 patients who had acute non-neoplastic PVT with the same
 inclusion criteria and were given symptomatic therapy for ascites, abdominal pain and
 followed synchronously with the study group.

 Laboratory investigations They included investigation preliminary to splenectomy as liver
 function tests, coagulation profile, renal function tests, complete blood count, reticulocyte
 count and bone marrow aspiration. For each patient, Child-Pugh (CTP) and MELD scores were
 calculated.

 Abdominal Ultrasonography (USG) Cirrhotic echo pattern, criteria of portal hypertension,
 ascites, HCC were excluded Color Doppler Sonography to confirm the diagnosis of PVT. Upper GI
 Endoscopy All the patients before splenectomy were exposed to upper GI endoscopy to detect
 the presence and grading of gastro-esophageal varices.

 Protocol of therapy Enoxaparin was initiated at a dose of 1mg/kg every 12 hours
 subcutaneously for 3 days then treatment was continued with rivaroxaban 10mg/12 hr.
 Rivaroxaban was started 2 hours before the next dose of enoxaparin.

 -  Follow up every week with a questionnaire about symptoms of bleeding (hematemesis,
 melena, epistaxis, gum bleeding, vaginal bleeding, subcutaneous bleeding), worsening or
 improvement of abdominal pain.

 -  Bedside ultrasonography for detection of thrombus resolution and presence or improvement
 of ascites every 2 weeks Laboratory follow-up which included serum creatinine, complete
 blood count, and liver function tests to detect if there any side effects of the therapy
 every 2 weeks.
Inclusion Criteria:

 -  Acute non-neoplastic portal vein thrombosis

 -  Compensated cirrhosis (Child class A-B)

 -  The onset of PVT is within 1 week.

 Exclusion Criteria:

 -  Decompensated liver disease

 -  Bleeding tendency or recent bleeding event as bleeding peptic ulcer or oesophageal
 varices

 -  Neoplastic invasion of the portal vein

 -  Renal impairment with the creatinine clearance ≤ 30 ml/min

 -  Pregnancy and breastfeeding

 -  Hypersensitivity to rivaroxaban

 -  Concomitant treatment with another anticoagulant

 -  Concomitant use of clopidogrel.