RISK FACTORS OF GALL BLADDER STONE
RISK FACTORS OF GALL BLADDER STONE
Gallbladder disease is a significant health burden in the developed world and its prevalence
 has risen by more than 20% in the past three decades In the United States, 20-25 million
 individuals are affected by gallbladder disease, resulting in an average annual treatment
 cost of $6.2 billion Obesity, diet, rapid weight loss, metabolic syndrome, and conditions
 such as cirrhosis, Crohn's disease, irritable bowel syndrome, and gallbladder stasis increase
 the risk of gallstone formation Surgical removal of the gallbladder, cholecystectomy, is the
 most recommended treatment for gallbladder disease; however, the procedure increases the risk
 of non-alcoholic fatty liver disease, cirrhosis and metabolic effects
Gallbladder disease is a significant health burden in the developed world and its prevalence
 has risen by more than 20% in the past three decades .

 In the United States, 20-25 million individuals are affected by gallbladder disease,
 resulting in an average annual treatment cost of $6.2 billion Obesity, diet, rapid weight
 loss, metabolic syndrome, and conditions such as cirrhosis, Crohn's disease, irritable bowel
 syndrome, and gallbladder stasis increase the risk of gallstone formation .

 Surgical removal of the gallbladder, cholecystectomy, is the most recommended treatment for
 gallbladder disease; however, the procedure increases the risk of non-alcoholic fatty liver
 disease, cirrhosis and metabolic effects .

 Oral dissolution therapy using ursodeoxycholic acid is currently one of the leading
 non-invasive alternative treatments for gallstones. Ursodeoxycholic acid dissolves small
 cholesterol gallstones by decreasing hepatic secretion of cholesterol and lowering the
 chances of unsaturated gallbladder bile formation Although oral dissolution therapy has
 proven to be a safe alternative to cholecystectomy, it has a gallstone recurrence rate of
 50%-70% at 12 years post-treatment .

 The high incidence rate and treatment cost associated with gallbladder disease have
 encouraged the search for preventative strategies. In approximately 75% of cases, impaired
 gallbladder motility results from the accumulation of cholesterol gallstones. Therefore,
 agents that reduce lipid concentrations or improve gallbladder motility may reduce the need
 for surgical interventions and/or the use of potentially harmful pharmaceutical products .
Inclusion Criteria:

 Adult patients who have gall bladder stone(s)

 Exclusion Criteria:

 Child -