FAZA PET/MRI in CLI Patients Pre and Post Revascularization
FAZA PET/MRI in CLI Patients Pre and Post Revascularization
Peripheral artery disease is a worldwide problem, leading to high mortality and mobility.

 Critical limb ischemia (CLI) is associated with high risk of amputation with the subsequent
 decreased in life quality. Endovascular therapy is now considered the primary treatment
 option in these patients to improve the vascularity and prevent amputations.

 In recent years, development of molecular imaging tools are now become available. A recent
 radio tracer named 18F-Fluoroazomycin Arabinoside (FAZA) its an specific marker of hypoxia in
 the tissues and has been used in multiples studies. This tracer can be used in PET/MR scan
 providing a potentially power diagnostic tool in patients with CLI, allowing in one
 diagnostic study the evaluation of location and degree of hypoxia in the extremity tissues.
 This diagnostic tool may offer a better assessment pre and post standard of care endovascular
 treatment for the patients.

 Moreover, some of the patients treated with endovascular therapy may not have a favorable
 outcome, without a clear reason explaining this situation. We will try to find some predictor
 model in the FAZA PET/MR that can explain the different outcomes and may help clinicians
 choose the best treatment option in specific cases.

 Thirdly, post processing for optimization of the MR sequences in patients with CLI will be
 performed at the MR component of the PET. There would thus be great clinical interest in
 developing non-invasive tools that could provide more accurate diagnostic information
 compared to traditional tests for these patients population.
Inclusion Criteria:

 -  Age >= 18 years;

 -  Patients with clinical evidence of critical limb ischemia that are candidates for
 revascularization treatment;

 -  A negative urine or serum pregnancy test in women of child-bearing age;

 -  Ability to provide written informed consent to participate in the study.

 Exclusion Criteria:

 -  Contraindication for MR as per current institutional guidelines;

 -  Inability to lie supine for at least 30 minutes;

 -  Pregnant or breastfeeding;

 -  Unable or unwilling to provide informed consent;

 -  Impending amputation within 6 weeks of presentation;

 -  Previous metallic hardware in the lower limbs;

 -  Unable to have ethanol.