GSK372475 PK Study in Healthy Volunteers
GSK372475 PK Study in Healthy Volunteers
This study will consist of 4 parallel cohorts of healthy volunteers (elderly male, elderly
 female, young male and young female). Subjects will receive either GSK372475 1.5mg or placebo
 for 28 days.
Inclusion Criteria:

 -  Healthy as determined by a responsible physician, based on a medical evaluation
 including medical and psychiatric history (including family history), full physical
 examination, laboratory tests and cardiac monitoring.

 -  Male or female between 18 and 45 years of age (young healthy population) and >65 years
 old (elderly population).

 -  A female subject is eligible to participate if she is of:

 -  Non-childbearing potential defined as pre-menopausal females with a documented tubal
 ligation or hysterectomy; or postmenopausal defined as 12 months of spontaneous
 amenorrhea

 -  Child-bearing potential and agrees to use of specific contraception methods. Use of
 oral contraception is permitted.

 -  BMI within the range 19 - 29 kg/m2 (inclusive).

 -  Capable of giving written informed consent, which includes compliance with the
 requirements and restrictions listed in the consent form.

 -  QTcB or QTcF < 450 msec; or QTc < 480 msec in subjects with Bundle Branch Block.

 -  Able to swallow and retain oral medication

 Exclusion Criteria:

 -  A subject will not be eligible for inclusion in this study if any of the following
 criteria apply:

 -  Evidence or history of clinically significant hematological, renal, endocrine,
 pulmonary, gastrointestinal, cardiovascular or other heart disease, glaucoma,
 diabetes, hepatic, neurologic (e.g. including but not limited to seizures, stroke,
 cerebrovascular disease or other brain conditions), or allergic disease (except for
 untreated, asymptomatic, seasonal allergies at time of dosing).

 -  Psychiatric illness currently or within the past year, or any lifetime history of
 bipolar disorder, major depressive disorder, anxiety disorder, schizophrenia or other
 psychotic disorder, or substance abuse or dependence (except past history of nicotine
 abuse/dependence).

 -  Subjects who, in the investigator's judgment, pose a suicidal or homicidal risk, or
 any subject with a history of suicidal or homicidal attempts or behaviour.

 -  The subject has a positive pre-study drug/alcohol screen. A minimum list of drugs that
 will be screened for include amphetamines, barbiturates, cocaine, opiates,
 cannabinoids and benzodiazepines.

 -  A positive pre-study Hepatitis B surface antigen or positive Hepatitis C antibody
 result within 3 months of screening (with the exception of phase I hepatic impairment
 studies, oncology studies, hepatitis, hepatic fibrosis, or HIV studies).

 -  A positive test for HIV antibody.

 -  History of regular alcohol consumption within 6 months of the study defined as:

 -  an average weekly intake of greater than 21 units or an average daily intake of
 greater than 3 units (males), or defined as an average weekly intake of greater than
 14 units or an average daily intake of greater than 2 units (females). One unit is
 equivalent to a half-pint (220mL) of beer or 1 (25ml) measure of spirits or 1 glass
 (125ml) of wine.

 -  The subject has participated in a clinical trial and has received an investigational
 product within the following time period prior to the first dosing day in the current
 study: 60 days i.e. 5 half-lives.

 -  Exposure to more than four new chemical entities within 12 months prior to the first
 dosing day.

 -  Use of prescription or non-prescription drugs, including vitamins, herbal and dietary
 supplements (including St John's Wort) within 7 days (or 14 days if the drug is a
 potential enzyme inducer) or 5 half-lives (whichever is longer) prior to the first
 dose of study medication, unless in the opinion of the Investigator and GSK Medical
 Monitor the medication will not interfere with the study procedures or compromise
 subject safety.

 -  History of sensitivity to any of the study medications, or components thereof or a
 history of drug or other allergy that, in the opinion of the investigator or GSK
 Medical Monitor, contraindicates their participation.

 -  Where participation in the study would result in donation of blood or blood products
 in excess of 500 mL within a 56 day period.

 -  Pregnant females as determined by positive serum or urine hCG test at screening or
 prior to dosing.

 -  Lactating females.

 -  Administration of a monoamine oxidase inhibitor (MAOI) within 30 days prior to Study
 Day 1, or anticipated use within 12 weeks following the last dose of study drug.

 -  Unwillingness or inability to follow the procedures outlined in the protocol.

 -  History of sensitivity to heparin or heparin-induced thrombocytopenia.

 -  Consumption of grapefruit juice or grapefruit or cruciferous vegetables (e.g.
 broccoli, Brussels sprouts, cabbage, cauliflower, chard, kale, mustard greens,
 rutabagas and turnips) and charbroiled foods within 7 days prior to first dose of
 study medication until follow-up.

 -  Controlled or uncontrolled hypertension, or systolic blood pressure ≥140 mmHg or
 diastolic blood pressure ≥90 mmHg at screening or prior to the first dose of study
 medication.