Transit Time and Bacterial Overgrowth Using SmartPill Capsule
Transit Time and Bacterial Overgrowth Using SmartPill Capsule
The primary purpose of this exploratory study is to measure orocecal transit time using the
 SmartPill ambulant capsule technology and to compare this with the lactulose hydrogen breath
 test. Additionally, the ability of the SmartPill GI Monitoring System to discriminate between
 healthy human subjects and patients with small bowel bacterial overgrowth will be explored
 using analyses of both pH and pressure patterns within the stomach and small intestine. The
 study will be performed in both normal subjects and patients with and without small bowel
 bacterial overgrowth.
Small bowel bacterial overgrowth (SBBO), an increasingly recognized malabsorptive condition
 caused by the excessive growth of bacteria in the small bowel, results in a spectrum of
 symptoms such as diarrhea, bloating abdominal discomfort and weight loss. Multiple factors
 both internal and external to the individual prevent excessive small bowel bacterial
 colonization and determine the types of bacteria present. The most important factors within
 the individual are normal small bowel motility, which prevents attachment of ingested
 organisms, and gastric acid, which destroys many organisms before they reach the small
 intestine. The determination of small bowel motility is problematic due to limitations of the
 tests available (e.g., hydrogen breath test, scintigraphy and manometry).

 The SmartPill capsule is a recently developed novel device that, following its ingestion, can
 measure pH, pressure and temperature as it moves through the gastrointestinal tract. These
 recordings can be used to measure gastrointestinal transit and, potentially, other aspects of
 gastrointestinal motility/function. Previous studies using this device have demonstrated the
 ability of the SmartPill to measure the gastric residence time using the duration of acidic
 pH recording with good correlation between the gastric residence time of the SmartPill
 capsule and conventional gastric emptying scintigraphy.
Inclusion Criteria for Healthy Subjects:

 1. Mentally competent and able to give informed consent.

 2. Healthy males and females between 18-70 years of age with no current or previous
 chronic gastrointestinal symptoms.

 Inclusion Criteria for Symptomatic Subjects:

 1. Males and females between 18-70 years of age with symptoms suggestive of small bowel
 bacterial overgrowth (e.g., diarrhea, bloating, abdominal discomfort) for at least 3
 months during the previous 12 months (need not be consecutive) who recently underwent
 an evaluation for small bowel bacterial overgrowth by either hydrogen breath testing
 or culture of small bowel aspirate.

 2. Ability to stop laxatives and prokinetic and narcotic analgesic agents 3 days prior to
 the study and during the study period.

 3. Ability to stop proton pump inhibitors 7 days prior to the study and histamine type-2
 receptor antagonists (H_2RAs) for 3 days prior to the study and during the study
 period.

 Exclusion Criteria:

 1. Subjects who are unable or unwilling to give informed consent or return for all
 required study visits.

 2. Prior gastrointestinal surgery which has altered the anatomy of the esophagus, stomach
 or small/large intestine (exceptions include appendectomy, cholecystectomy and
 fundoplication).

 3. Hypersensitivity to rifaximin.

 4. Use of any medications in the previous week that could alter gastrointestinal motor
 function.

 5. Body Mass Index (BMI) > 38.

 6. Previous history of bezoars.

 7. Any abdominal surgery within the past 3 months.

 8. Known or history of inflammatory bowel disease.

 9. History of diverticulitis, diverticular stricture, and other intestinal strictures.

 10. Tobacco use within eight hours prior to capsule ingestion and during the initial 8
 hour recording on the first day.

 11. Alcohol use within eight hours prior to capsule ingestion and throughout the entire
 monitoring period (up to 5 days).

 12. Females of childbearing age who are not practicing birth control and/or are pregnant
 or lactating (A urine pregnancy test will be performed on female subjects prior to
 capsule ingestion).

 13. Cardiovascular, endocrine, renal or other chronic disease likely to affect motility.

 14. Use of medical devices such as pacemakers, infusion pumps, or insulin pumps.