Light-emitting Diodes (LED) Phototherapy for Hyperbilirubinemia of Term Newborn
Light-emitting Diodes (LED) Phototherapy for Hyperbilirubinemia of Term Newborn
Phototherapy is almost (beside exchange transfusion) the unique treatment for
 hyperbilirubinemia of the newborn. Its efficacy to decrease bilirubin level (because the
 light interacts with bilirubin at the skin level to transform it in water soluble products
 eliminated in urine and stools without liver metabolism) relies on the irradiance dispensed
 at the skin level by the device (in the 430-490nm range) and on the exposed surface of the
 baby. In the past years, technology of phototherapy devices moved from fluorescent lamps to
 LED, improving the amount of light energy emitted but on a smaller surface. The purpose of
 the study is to compare the efficacy of three ramps of phototherapy, one equipped with
 fluorescent tubes and two with LED (in a different technological settings) in the treatment
 of term (35 GW or more) healthy newborn suffering hyperbilirubinemia after 2days of life.
Term and healthy newborns on maternity wards in SAINT-ANTOINE hospital are checked everyday
 for jaundice with bilirubinometer JM-103®. If indicated (nomogram included in patient
 charts), a plasmatic bilirubin level is performed. If the baby is two days old or more with a
 bilirubin level indicating standard phototherapy (by opposition to intensive phototherapy),
 the parents are informed of the research protocol and after obtention of parental consent,
 the baby is included. The newborn is admitted in the neonatology unit and randomised in one
 of the three phototherapy devices group. Plasmatic bilirubin levels are checked at 6,12 and
 24 and 48 hours of phototherapy. At 12 hours of phototherapy, a biological checking is
 performed to address the etiology of the jaundice. The next plasmatic bilirubin level is
 performed at 72h after inclusion. During phototherapy treatment the baby is continuously
 monitored. Phototherapy is stopped when bilirubin level is below 200µmol/l. If the bilirubin
 level is increasing under one of this ramps or does not decrease at H24, the baby will be
 immediately move on intensive phototherapy and participation at the research protocol
 interrupted. Twenty four hours after the end of phototherapy treatment, plasmatic bilirubin
 level is checked to confirm the end of jaundice and statement is made for jaundice origin.
 The total duration of participation of a baby at this study is 72 hours.
Inclusion Criteria:

 -  Newborns in the hospital SAINT ANTOINE maternity wards

 -  Gestational age of 35w or more

 -  Healthy (no hypoxemia, no hypotonia, no abnormalities of thermic regulation, no
 infection or dehydration)

 -  No foeto-maternal incompatibility in rhesus or kell group

 -  With bilirubin level at 48h of 220µmoles/l or more if born at 38W or more or of
 200µmoles/l or more if born between 35 and 38 W

 -  Parental information done and signed consent obtained

 -  Parents affiliated to social security

 Exclusion Criteria:

 -  Conjugated bilirubin level at 25µmol/l or more

 -  Total bilirubin level over 300µmol/l indicating "intensive phototherapy"

 -  Baby treated by phototherapy in the days before inclusion

 -  Severe haemolytic disease with anemia below 14g/land or hyperbilirubinemia before 48h
 of life), rhesus or kell incompatibility

 -  Parents who could not understand the information or sign the consent.