Study of Fluzone® Quadrivalent, Fluzone® Intradermal Quadrivalent, and Fluzone® High-Dose, Influenza Vaccines in Adults
Study of Fluzone® Quadrivalent, Fluzone® Intradermal Quadrivalent, and Fluzone® High-Dose, Influenza Vaccines in Adults
The aim of the study is to evaluate the safety and immunogenicity of the 2015-2016
 formulations of Fluzone Quadrivalent and Fluzone Intradermal Quadrivalent vaccines in adults
 18 to < 65 years of age, and of the 2015-2016 formulations of Fluzone Quadrivalent and
 Fluzone High-Dose vaccines in adults ≥ 65 years of age.

 Primary Objective:

 - To describe the safety of the 2015-2016 formulations of Fluzone Quadrivalent and Fluzone
 Intradermal Quadrivalent vaccines in adults 18 to < 65 years of age and the safety of the
 2015-2016 formulations of Fluzone Quadrivalent and Fluzone High-Dose vaccines in adults ≥ 65
 years of age.

 Observational Objectives:

 -  To describe the immunogenicity of the 2015-2016 formulations of Fluzone Quadrivalent and
 Fluzone Intradermal Quadrivalent vaccines in adults 18 to < 65 years of age and the
 immunogenicity of the 2015-2016 formulations of Fluzone Quadrivalent and Fluzone
 High-Dose vaccines in adults ≥ 65 years of age.

 -  To evaluate the compliance, in terms of immunogenicity, of each study vaccine (Fluzone
 Quadrivalent, Fluzone Intradermal Quadrivalent, and Fluzone High-Dose) in the applicable
 age group with the historical requirements of the Committee for Human Medicinal Products
 (CHMP) Note for Guidance (NfG) Committee for Propriety Medicinal Products (CPMP) - CHMP
 NfG CPMP/BWP/214/96.
Adults age 18 to < 65 years will be randomly assigned to receive either Fluzone Quadrivalent
 or Fluzone Intradermal Quadrivalent vaccine and adults age ≥ 65 years will be randomly
 assigned to receive either Fluzone Quadrivalent or Fluzone High-Dose vaccine. All subjects
 will receive a single dose of their randomly assigned vaccine.

 They will be followed from Visit 1 to Visit 2 for evaluation of safety outcomes. Solicited
 adverse reactions will be collected for 7 days after vaccination. Unsolicited non-serious
 adverse events (AEs) and serious adverse events (SAEs) will be collected from Visit 1 to
 Visit 2.
Inclusion Criteria:

 -  Subject is ≥ 18 years of age on the day of inclusion

 -  Informed consent form has been signed and dated

 -  Able to attend all scheduled visits and to comply with all trial procedures.

 Exclusion Criteria:

 -  History of serious adverse reaction to any influenza vaccine

 -  Receipt of any vaccine within 30 days before receiving study vaccine, or plans to
 receive another vaccine before Visit 2

 -  Participation in another interventional clinical trial investigating a vaccine, drug,
 medical device, or medical procedure in the 30 days preceding the first study
 vaccination or during the course of the study, unless no intervention for the other
 study occurred within the 30 days prior to the first study vaccination and none are
 planned before the subject would complete safety surveillance for the present study

 -  Thrombocytopenia, which may be a contraindication for intramuscular vaccination, at
 the discretion of the Investigator

 -  Prior vaccination with any 2015-2016 formulation of influenza vaccine

 -  Known systemic hypersensitivity to eggs, chicken proteins, or any of the vaccine
 components, or a history of a life-threatening reaction to Fluzone Quadrivalent,
 Fluzone Intradermal Quadrivalent, or Fluzone High-Dose vaccine or to a vaccine
 containing any of the same substances (the complete list of vaccine components is
 included in the Prescribing Information)

 -  Receipt of immune globulins, blood, or blood-derived products in the past 3 months

 -  Bleeding disorder or receipt of anticoagulants in the 3 weeks preceding inclusion,
 which may be a contraindication for intramuscular vaccination, at the discretion of
 the Investigator

 -  Subject is pregnant, or lactating, or of childbearing potential (to be considered of
 non-childbearing potential, a female must be post-menopausal for at least 1 year,
 surgically sterile, or using an effective method of contraception or abstinence from
 at least 4 weeks prior to vaccination and until at least 4 weeks after vaccination)

 -  Any condition that in the opinion of the Investigator would pose a health risk to the
 subject if enrolled or could interfere with the evaluation of the vaccine

 -  Personal history of Guillain-Barré syndrome

 -  Known or suspected congenital or acquired immunodeficiency; or receipt of
 immunosuppressive therapy, such as anti-cancer chemotherapy or radiation therapy,
 within the preceding 6 months; or long-term systemic corticosteroid therapy
 (prednisone or equivalent for more than 2 consecutive weeks within the past 3 months)

 -  Chronic illness that, in the opinion of the Investigator, is at a stage where it might
 interfere with trial conduct or completion

 -  Seropositivity for human immunodeficiency virus, hepatitis B, or hepatitis C, as
 reported by the subject.

 -  Deprived of freedom by an administrative or court order, or in an emergency setting,
 or hospitalized involuntarily

 -  Current alcohol or drug addiction that, in the opinion of the Investigator, might
 interfere with the ability to comply with trial procedures

 -  Moderate or severe acute illness/infection (according to Investigator judgment) or
 febrile illness (temperature ≥ 100.4°F) on the day of vaccination. A prospective
 subject should not be included in the study until the condition has resolved or the
 febrile event has subsided

 -  Identified as an Investigator or employee of an Investigator or study center with
 direct involvement in the proposed study, or identified as an immediate family member
 (i.e., parent, spouse, natural or adopted child) of an Investigator or employee with
 direct involvement in the proposed study.