Cytokines and Acute Phase Reactants as Markers of Pulmonary Tuberculosis Treatment
Cytokines and Acute Phase Reactants as Markers of Pulmonary Tuberculosis Treatment
Tuberculosis is a highly prevalent chronic infectious disease caused by Mycobacterium
 tuberculosis. Cytokines are important biological mediators that regulate immune and
 inflammatory responses against the bacilli, witch include the acute phase response. Besides
 this, it becomes essential to determine markers of healing lesions, once this is currently
 carried out based on the clinical, radiological, and negative bacterioscopy.
Tuberculosis is a highly prevalent chronic infectious disease caused by Mycobacterium
 tuberculosis. Cytokines are important biological mediators that regulate immune and
 inflammatory responses against the bacilli, witch include the acute phase response. Besides
 this, it becomes essential to determine markers of healing lesions, once this is currently
 carried out based on the clinical, radiological, and negative bacterioscopy. The propose of
 this work was to evaluate the production of IFN- γ in cell supernatants of peripheral blood
 mononuclear cells (PBMC) culture, TNF-α, IL-10 and TGF-b in cell supernatants of monocytes
 (MO) culture and biochemical (total proteins, albumin, globulin, α-1-acid glycoprotein and
 C-reactive protein) and hematological (VHS) serum parameters before and after 3 and 6 months
 of therapy
Inclusion Criteria:

 -  diagnosis of Mycobacterium tuberculosis infection

 Exclusion Criteria:

 -  all other granulomatous or neoplastic diseases