Diagnosis of Cow's Milk Protein Allergy
Diagnosis of Cow's Milk Protein Allergy
The study will assess the diagnosis of cow's milk protein allergy (CMPA) among infant and
 children in assiut university children hospital using skin prick test and specific serum IgE
 as well as their management.
Food allergy is a reproducible specific immune response to exposure to a given food. Cow's
 milk protein allergy (CMPA) is clinically abnormal reaction to cow's milk protein (CMP) via
 immune mechanisms triggered by milk protein (Boyce etal.,2010).

 According to European academy for allergy and clinical immunology (EAACI) and the world
 allergy organization (wao) , a hypersensitivity reaction to cow's milk involving the immune
 system can be called as CMPA. There is difference between CMPA and non-allergic cow's milk
 intolerance (e.g lactose intolerance) which occurs as a result of lactase deficiency without
 involvement of the immune system (Venter etal.,2013).

 CMPA is categorized into immunoglobulin IgE mediated , non -IgE mediated ,or mixed CMPA
 (Sicherer etal.,2001).

 1.9% to 4.9% prevalence of CMPA among children with a peak in prevalence (2-3%) in the first
 year of life and prevalence of <1% in children aged >=6 years (koletzko etal.,2012).
Inclusion Criteria:

 -  - Exclusively breast feeding ,breast-fed infants with supplementary foods and
 non-breast fed infants with supplementary foods who complain from either frequent
 regurgitation, vomiting,diarrhea,constipation (with/without perianal rash) ,blood in
 stool or pallor.

 Exclusion Criteria:

 -  : Infant and child with gastrointestinal symptoms due to specific etiology.