Local Infiltration Analgesia in Total Knee Arthroplasty
Local Infiltration Analgesia in Total Knee Arthroplasty
40 patients ASA I-III, undergoing total knee arthroplasty were randomly assigned, into one of
 two groups, namely group LIA (n=20), where local infiltration analgesia would be administered
 intraoperatively; and group sham LIA (n=20), where sham injections of normal saline would be
 administered. All patients received a standardized multimodal approach, including pregabalin,
 adductor canal peripheral nervous blockade, spinal anaesthesia, paracetamol, and PCA with
 morphine. Morphine consumption during the first 24 hours postoperatively was measured and
 additionally the investigators recorded: Time of morphine first dose administration, NRS
 scores in static and dynamic conditions in 6 hours, 12 hours, 18 hours and 24 hours
 postoperatively, complications, patient satisfaction and duration of hospitalization.
Inclusion Criteria:

 -  Physical status according to American Society of Anesthesiologists (ASA) I-III

 -  Patients scheduled for total knee arthroplasty

 Exclusion Criteria:

 -  Contraindication for central and/or peripheral nervous blockade

 -  Reoperation on previous total knee arthroplasty

 -  History of allergic or other adverse reactions on the agents used in the study

 -  Chronic opioid or gabapentinoid use

 -  Serious psychiatric, mental and cognitive disorders

 -  Language barrier

 -  Difficulty in understanding or using a patient controlled analgesia device