Generation of Anti-HCV Antibodies From Bone Marrow: Defining the Repertoire of Immune Response to HCV Quasispecies
Generation of Anti-HCV Antibodies From Bone Marrow: Defining the Repertoire of Immune Response to HCV Quasispecies
To generate a library of genes that reflect the entirety of antibody responses to hepatitis C
 virus (HCV) made during the 20-year course of HCV infection in a single patient (WH) whose
 viral quasispecies has been extensively characterized. In addition to characterizing the
 sequential events in antibody formation and their relationship to the changing pattern of
 viral quasispecies, we hope to identify neutralizing antibodies and the epitopes to which
 they are directed. Ultimately we seek to gain insight into the host mechanisms that suppress
 viral replication and to translate this to therapeutic and preventive modalities.
To generate a library of genes that reflect the entirety of antibody responses to hepatitis C
 virus (HCV) made during the 20-year course of HCV infection in a single patient (WH) whose
 viral quasispecies has been extensively characterized. In addition to characterizing the
 sequential events in antibody formation and their relationship to the changing pattern of
 viral quasispecies, we hope to identify neutralizing antibodies and the epitopes to which
 they are directed. Ultimately we seek to gain insight into the host mechanisms that suppress
 viral replication and to translate this to therapeutic and preventive modalities.
Persistent infection with mild hepatitis that is non-progressive.