Allergic Versus Non Allergic Hypersensitivity Drug Reaction (BdDAllergo)
Allergic Versus Non Allergic Hypersensitivity Drug Reaction (BdDAllergo)
The creation of a database containing the medical data of patients followed in allergology at
 the University Hospital of Grenoble will permit to study allergic versus non-allergic
 hypersensitivity drug reaction as well as the risk of cross-reactions between medicinal drugs
 belonging to the same pharmacological class.

 The main objectives of the study are to estimate and to compare the proportion of allergic
 hypersensitivity drug reaction and the proportion of non allergic hypersensitivity drug
 reaction, and to characterize these two types of hypersensitivity drug reaction on clinical,
 biological and chronological aspects.

 In a second time, ancillary study will be conducted in order to :

 -  identify drugs that potentially induced histamine-liberation in patients diagnosed with
 non allergic hypersensitivity drug reaction

 -  investigate the risk of cross-reactions between drugs belonging to the same
 pharmacotherapeutic class in patients diagnosed with allergic hypersensitivity drug
 reaction.
This study is an observational cohort study conducted at University Hospital of Grenoble. It
 include retrospectively and prospectively the patients followed in the allergology department
 for the realization of immunoallergological test after suspicion of hypersensitivity drug
 reaction. The data are collected in a database from medical consultation reports that are
 systematically reported to the pharmacovigilance regional center. An anonymization number is
 assigned for each patient included in the study.The data collected include patient's personal
 and family medical history, a clinical, biological and chronological description of the
 hypersensitivity reaction, the results of the immunoallergologic skin tests as well as the
 final diagnosis.
Inclusion Criteria:

 -  Cases where a non-iatrogenic cause was finally identified

 Exclusion Criteria:

 -  For the estimation and comparison of the proportions, the patients who haven't carried
 out all their immunoallergologic tests investigations at the University Hospital of
 Grenoble are not included (this concerns patient who have realized only oral
 rechallenge test at hospital)

 -  To realize the comparative analysis of allergic versus non-allergic hypersensitivity
 drug reaction : cases that are insufficiently documented on clinical, biological and /
 or chronological aspects are excluded. This concerns especially patients who realize
 immunoallergologic tests investigations after a skin reaction that occurred "in
 childhood".