Diagnostic Accuracy of Optical Coherence Tomography in Upper Urinary Tract Urothelial Carcinoma
Diagnostic Accuracy of Optical Coherence Tomography in Upper Urinary Tract Urothelial Carcinoma
The purpose of this study is to establish in vivo sensitivity and specificity of OCT in the
 diagnosis of Upper Urinary Tract Urothelial Carcinoma.
Minimal invasive endoscopic treatment for Upper Urinary Tract Urothelial Carcinoma (UUT-UC)
 has been accepted as a treatment option instead of radical nephroureterectomy for patients
 with low grade, low stage disease. For this reason, information on tumour stage and grade is
 important for a clinical decision. Until now,diagnostic ureterorenoscopy combined with
 histology/cytology is the gold standard. Unfortunately, histology/cytology is often
 inconclusive.

 Optical Coherence Tomography is a new high resolution imaging technique that has potential to
 provide the urologist real time per-operative information of grade and stage of the disease.

 In this study the investigators aim to establish in vivo sensitivity and specificity of OCT
 in the diagnosis of Upper Urinary Tract Urothelial Carcinoma. Secondary objectives are
 inter-observer variability of 1300 nm OCT in the diagnosis of UUT-UC and optical properties
 of cancerous and healthy ureter and collecting system tissue in vivo in humans.
Inclusion Criteria:

 -  Candidate for diagnostic or therapeutic ureterorenoscopy

 -  Signed informed consent

 Exclusion Criteria:

 -  No signed informed consent