Temozolomide and O6-benzylguanine in Treating Patients With Newly Diagnosed, Recurrent, or Progressive Anaplastic Glioma
Temozolomide and O6-benzylguanine in Treating Patients With Newly Diagnosed, Recurrent, or Progressive Anaplastic Glioma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so
 they stop growing or die. Combining more than one drug may kill more tumor cells.

 PURPOSE: Phase I trial to study the effectiveness of combining temozolomide and
 O6-benzylguanine in treating patients who have newly diagnosed, recurrent, or progressive
 anaplastic glioma.
OBJECTIVES:

 -  Determine the dose of O6-benzylguanine (O6-BG) effective in producing complete
 suppression of tumor O6-alkylguanine-DNA alkyltransferase activity in patients with
 newly diagnosed (closed to accrual 12/19/2000) or recurrent or progressive cerebral
 anaplastic glioma.

 -  Determine the maximum tolerated dose of temozolomide administered after O6-BG in these
 patients.

 -  Determine the toxicity of this regimen in these patients.

 -  Determine the anti-tumor response in patients treated with this regimen.

 OUTLINE: This is a dose-escalation, multicenter study.

 -  Part I: Patients receive escalating doses of O6-benzylguanine (O6-BG) IV continuously
 for 49 hours until the dose that produces the target depletion of tumor
 O6-alkylguanine-DNA alkyltransferase (AGT) is determined. Patients undergo a craniotomy
 after completion of the O6-BG infusion. (closed to accrual 12/19/2000)

 -  Part II: After determination of the O6-BG dose in Part I, patients with recurrent
 malignant gliomas receive O6-BG IV continuously for 49 hours beginning on day 1.
 Patients also receive oral temozolomide on day 1. Treatment repeats every 28 days in the
 absence of disease progression or unacceptable toxicity.

 Cohorts of 3-6 patients receive escalating doses of temozolomide until the maximum tolerated
 dose (MTD) is determined. The MTD is defined as the dose at which no more than 1 of 6
 patients experiences dose-limiting toxicity.

 PROJECTED ACCRUAL: Approximately 20-30 patients (with 14 patients participating in Part II)
 will be accrued for this study.
DISEASE CHARACTERISTICS:

 -  Part I:

 -  Histologically confirmed, newly diagnosed glioblastoma multiforme or anaplastic
 astrocytoma (closed to accrual 12/19/2000)

 -  Parts I and II:

 -  Histologically confirmed astrocytic, oligodendroglial, or mixed glial tumor

 -  Grade III or higher

 -  Recurrent or progressive after radiotherapy

 -  Evaluable residual disease by contrast-enhanced MRI or CT scan

 PATIENT CHARACTERISTICS:

 Age:

 -  18 and over

 Performance status:

 -  Karnofsky 60-100%

 Life expectancy:

 -  Not specified

 Hematopoietic:

 -  Granulocyte count at least 1,500/mm3

 -  Platelet count at least 100,000/mm3

 Hepatic:

 -  SGOT no greater than 2.5 times upper limit of normal

 -  Bilirubin normal

 Renal:

 -  Creatinine no greater than 1.5 mg/dL OR

 -  Creatinine clearance greater than 60 mL/min

 -  BUN no greater than 25 mg/dL

 Other:

 -  Not pregnant or nursing

 -  Negative pregnancy test

 -  Fertile patients must use effective contraception during and for 2 months after study

 PRIOR CONCURRENT THERAPY:

 Biologic therapy:

 -  At least 6 weeks since prior biologic therapy and recovered

 Chemotherapy:

 -  At least 2 weeks since prior chemotherapy (including but not limited to topotecan) and
 recovered

 -  Patients in trials with one of the following treatment combinations are allowed
 to enroll 6 weeks after receiving carmustine (BCNU):

 -  BCNU on day 1

 -  BCNU on day 1 and topotecan on days 1, 8, 15, 22, 29, and 36

 -  BCNU on day 1 and irinotecan on days 1, 8, 15, and 22

 Endocrine therapy:

 -  Patients on corticosteroids must be on a stable dose for at least 2 weeks before study

 -  At least 6 weeks since other prior endocrine therapy and recovered

 Radiotherapy:

 -  See Disease Characteristics

 -  At least 6 weeks since prior radiotherapy and recovered

 Surgery:

 -  Not specified