Randomized Trial Between Weekly and 5 Day 3 Weekly Cisplatin for Cervical Cancer
Randomized Trial Between Weekly and 5 Day 3 Weekly Cisplatin for Cervical Cancer
The primary aim of this research protocol is to compare if there is a difference in
 progression free survival between weekly versus 5-day 3 weekly cisplatin based chemotherapy
 regimen in women with locally advanced cervical cancer. The secondary aims are to compare
 quality of life assessment of patients and their carers as well as toxicity profiles both
 acute and late.
Inclusion Criteria:

 -  stage IB2-IVA , histological proven cervical carcinoma

 -  no previous diagnosis of carcinoma

 -  no prior history of chemotherapy or radiotherapy

 -  ECOG less than or equal to 2

 -  Above 21 years old

 -  medically fit for radical concurrent Cisplatin based chemotherapy and radiotherapy

 -  Hemoglobin >10g/dL

 -  Adequate hematological, renal and hepatic function according to all of the following
 laboratory values:

 -  Absolute neutrophil count ≥ 1.5 ×109/l

 -  Platelets ≥ 100 ×109/l

 -  Serum creatinine ≤ 1.5 times upper limit of laboratory normal

 -  Total serum bilirubin ≤ 1.5 times upper limit of laboratory normal

 -  ASAT(AST) or ALAT(ALT) ≤ 2.5 times upper limit of laboratory normal

 -  Alkaline phosphatase of ≤ 2.5 times upper limit of laboratory normal

 Exclusion Criteria:

 -  Age below 21

 -  Presence of known HIV infection, chronic hepatitis B or hepatitis C infection

 -  Psychological, familial, sociological, or geographical condition that would preclude
 study participation

 -  Prior (within the last 3 years) or simultaneous malignancies (other then cutaneous
 basal cell carcinoma or non-invasive tumors)

 -  Patients with the following histologies are excluded: small cell, carcinoid, glassy
 cell, clear cell and adenoid cystic.

 -  Life expectancy < 6 months

 -  Patients with insulin dependent diabetes

 -  Prior tumor-directed surgery

 -  Previous systemic chemotherapy or pelvic radiation therapy

 -  As radiation and cytotoxic agents are contraindicated in pregnancy, pregnant women are
 ineligible and those of childbearing potential should use contraception