Gallstones and Concomitant Gastric Helicobacter Pylori Infection
Gallstones and Concomitant Gastric Helicobacter Pylori Infection
In this study, the presence of H.Pylori in the gallbladder mucosa of patients with
 symptomatic gallstones undergoing cholecystectomy was investigated. Concomitant H.Pylori
 infection of the gastric mucosa was also investigated to study the relationship of gastric
 H.Pylori infection to gallstones. It was hypothesized that H.Pylori infection of the gastric
 mucosa may have a role in the formation of gallstones.
Gallstone disease is one of the most common problems affecting the digestive tract where
 autopsy reports show a prevalence of 11-36% . The prevalence of gallstones is related to many
 factors including age, gender, and ethnic background. Women are three times more likely to
 develop gallstones than man and first-degree relatives have a two-fold increased prevalence .
 However, the etiology of gallstone formation beginning with the change in the composition of
 bile, leading to stones is not clear.

 The association between Helicobacter pylori (H.Pylori) and gallstones has been investigated
 but not clearly demonstrated. H.Pylori is a gram negative and micro-aerophilic microorganism
 that can cause chronic gastritis, gastric and duodenal ulcers, gastric adenocarcinoma and
 lymphoma of gastric mucosa-related lymphoid tissue (MALToma) . Relationship of H.Pylori with
 diseases of organs other than the stomach and duodenum has also been investigated and
 reported . H.Pylori have been detected in the gallbladder mucosa of patients with gallstones
 .

 In this study, the presence of H.Pylori in the gallbladder mucosa of patients with
 symptomatic gallstones undergoing cholecystectomy was investigated. Concomitant H.Pylori
 infection of the gastric mucosa was also investigated to study the relationship of gastric
 H.Pylori infection to gallstones. It was hypothesized that H.Pylori infection of the gastric
 mucosa may have a role in the formation of gallstones.
Inclusion Criteria:

 -  Patients with acute cholecystitis, cholangitis, biliary and hepatic tumors, Crohn's
 disease, and previous gastric surgery were not considered suitable for evaluation.

 Exclusion Criteria:

 -  Patients undergoing ERCP (endoscopic retrograde cholangio-pancreatography) and
 patients who have received H.Pylori eradication treatment in the last 6 month were
 also excluded from the study.