Effectiveness Study of Ketoconazole and Betamethasone to Treat Fungal Infection and Dermatophytosis
Effectiveness Study of Ketoconazole and Betamethasone to Treat Fungal Infection and Dermatophytosis
To evaluate the no-inferiority of the ketoconazole20mg/g and betamethasone dipropionate 0.64
 mg/g association (Candicort®) cream versus clotrimazole 10mg and dexamethasone acetate 0.443
 mg/g association (Baycuten N®) cream, general relief of signs and symptoms (erythema,
 maceration, peeling, blistering / papules / pustules, itching and burning / stinging) 06 (±
 1) days after onset treatment.
Candicort® presents formulation with agents that act both etiological agent of superficial
 mycosis, with coverage for dermatophytes and more frequent yeast; as inflammation generated
 by the infectious process or prior to it, in cases of secondary fungal infection in wet or
 potentially infected eczema fungal dermatitis (atopic dermatitis, seborrhoeic dermatitis,
 intertrigo, dyshidrosis, contact dermatitis).

 The active ingredients ketoconazole and betamethasone act, respectively, on the etiologic
 agent of the infection and the inflammation generated by the process, and the association of
 both showed a positive therapeutic response in dermatitis with confirmed secondary infections
 or potential yeast (analysis carried out in association with sulfate neomycin, aimed to cover
 bacterial infections together).

 160 participants that meet all the inclusion criteria and are not classified in any of the
 exclusion criteria will be randomly allocated to one of two treatment groups(Candicort® or
 Baycuten N®) of the study.
Inclusion Criteria:

 -  Ability to understand and consent to participate in this clinical research, expressed
 by signing the Informed Consent Form (ICF);

 -  Participants with moderate or severe clinical diagnosis of superficial mycoses caused
 by Candida ssp or following fungal /dermatophytosis infections: inflammatory tinea
 corporis inflammatory (except face), inflammatory tinea cruris and inflammatory tinea
 pedis, with confirmation through direct mycological examination. In moderate or severe
 superficial mycosis that present at least moderate erythema and itching signs and
 slight peeling according to the evaluation by the four-point category scale (0=absent,
 1-mild, 2-moderate, 3-severe);

 Exclusion Criteria:

 -  Any observational finding (clinical/ physical evaluation) that is interpreted by the
 investigator as a risk to the research participant's participation in the clinical
 trial;

 -  Known hypersensitivity to the drug components used during the study;

 -  Use of prohibited drugs and treatment prohibited in the last 90 days;

 -  Immune impairment, according to investigator assessment;

 -  Vulvovaginal candidiasis diagnostics, balanopreputial, nail, chronic mucocutaneous or
 oral;

 -  Diagnosis of chickenpox, rosacea, herpes simplex or zoster, skin tuberculosis or skin
 syphilis, systemic fungal infection;

 -  Participants who, though they have studied diagnosis of fungal infections requiring
 systemic treatment according to the severity of injury and according to the opinion of
 the investigator;

 -  Participants that have skin lesions with clinical signs of bacterial infection;

 -  Participants who, according to investigator assessment, require systemic antibiotic
 treatment;

 -  Participants that are in any treatment , in the opinion of the investigator, may
 affect the results of the study;

 -  Participants diagnosed with HIV;

 -  Participants diagnosed with Diabetes Mellitus;

 -  Participants with a history of smallpox vaccine reaction;

 -  Women in gestation period or who are breastfeeding;

 -  Female participants who are in the reproductive age and do not agree to use acceptable
 methods of contraception (oral contraceptives, injectable contraceptives, intrauterine
 device (IUD), hormonal implants, barrier methods, hormonal patch and tubal ligation);
 except surgically sterile (bilateral oophorectomy or hysterectomy), the menopausal for
 at least one year and participants who declare to perform sexual practices on a not to
 reproductive way;

 -  Participant who participated in clinical in the last twelve months, unless the
 investigator considers that there may be direct benefit to thereof;

 -  Participant has some kinship of second degree or bond with employees or employees of
 Sponsor and Research Center.