Novel Classification of Adult-onset Diabetes and Its Association With Common Microvascular Complications in Upper Egypt
Novel Classification of Adult-onset Diabetes and Its Association With Common Microvascular Complications in Upper Egypt
Aim of our work:

 First aim: Classify patients with adult-onset diabetes according to the novel classification
 into new subgroups, depending on multiple variables related clinically to those patients.

 Second aim: To identify the association between the new classification subgroups and the
 presence of common microvascular complications (retinopathy, nephropathy, and neuropathy),
 which can help in the early prediction of these complications and their early management.
We will conduct an observational cross-sectional study and cluster analysis for patients from
 different Diabetes clinics and tertiary centres located in different governorates in Upper
 Egypt. Our participants in this study will be divided into two groups:

 1. The first group will be as a prospective group, All necessary examinations and
 investigations will be performed for every patient of this group during their clinic
 visit at the time of registration to this study.

 2. The second group will be the retrospective group. Data for those patients will be
 collected from electronic records and/or paper records in collaboration with different
 diabetes centres and clinics scattered in Upper Egypt governorates. We will collect
 clinical and lab data as much as we can. All available data for this group at end of
 this study will be used in the clustering of this group.

 Then we will use the above data from both groups to classify diabetic patients to the new
 clusters and to find the association between those clusters and the incidence of
 microvascular complications.
Inclusion Criteria:

 -  Adult-onset DM type 2 diagnosed patients according to current ADA recommendations,
 aged <18 years old and within 3 years from the time of diagnosis.

 Exclusion Criteria:

 -  1- Patients diagnosed with Gestational DM or rare types of diabetes like monogenic
 diabetes types, such as maturity-onset diabetes of the young (MODY), diabetes
 secondary to steroid use, cystic fibrosis, hemochromatosis, and pancreatic diabetes
 according to ADA criteria.

 2- Patients diagnosed with non-diabetic kidney diseases, such as chronic
 glomerulonephritis, vasculitis, polycystic kidney disease, and renal cancer or
 patients with a transplanted kidney were excluded from the analysis for diabetic
 kidney disease.

 3- Patients diagnosed with retinopathy due to non-diabetic causes or diagnosed with
 neuropathy due to non-diabetic causes will be excluded from the analysis for diabetic
 retinopathy and neuropathy, respectively.