Autologous Neo-Bladder Construct in Non-Neurogenic Overactive Bladder and Urge Predominant Incontinence
Autologous Neo-Bladder Construct in Non-Neurogenic Overactive Bladder and Urge Predominant Incontinence
Subjects with non-neurogenic over-active bladder will be enrolled. The hypothesis is that
 augmentation cystoplasty using an autologous neo-bladder construct will increase functional
 capacity and thereby reduce the number of micturition episodes per day in subjects with
 non-neurogenic over active bladder and urge predominant incontinence.
Subjects with non-neurogenic over-active bladder and urge predominant incontinence who are
 intolerant to medical therapy or have persistence of symptoms despite medical therapy and
 require augmentation cystoplasty will be enrolled. The hypothesis is that augmentation
 cystoplasty using an autologous neo-bladder construct will increase functional capacity and
 thereby reduce the number of micturition episodes per day in subjects with non-neurogenic
 over active bladder and urge predominant incontinence.
Inclusion Criteria:

 -  History of non-neurogenic overactive bladder for at least 12 months prior to study
 entry

 -  Intolerance to medical therapy or persistence of symptoms despite medical therapy

 Exclusion Criteria:

 -  Subjects with stress incontinence or mixed incontinence where the predominant
 component is stress incontinence

 -  Use of Botulinum Toxin A injections into the bladder within the previous 6 months

 -  Presence of a neuromodulator

 -  Using catheterization as a way to control incontinence

 -  History of bladder cancer