The Effect of Weight Loss on Serum Mannose-Binding Lectin(MBL) Levels
The Effect of Weight Loss on Serum Mannose-Binding Lectin(MBL) Levels
High levels of mannose-binding lectin (MBL), an activator of a part of the immune system
 called the complement system, have been associated with increased mortality and risk of early
 signs of kidney damage in patients with type 2 diabetes. The effect of weight loss and
 changes in insulin resistance on MBL levels have been poorly elucidated.

 This study includes 36 nondiabetic obese subjects, who will receive a very low- calorie diet
 (VLCD) of 800 kcal/day for 8 weeks.

 Fasting blood samples will be obtained at baseline and after 8 weeks of VLCD and
 concentrations of MBL, glucose and insulin will be measured. Insulin resistance is assessed
 using the HOMA-IR method.
Inclusion Criteria:

 -  Obese

 Exclusion Criteria:

 -  Diabetes

 -  Other severe disease