Relationship Between Normal-weight Central Obesity and Obstructive Sleep Apnea
Relationship Between Normal-weight Central Obesity and Obstructive Sleep Apnea
Comparison of the prevalence of obstructive sleep apnea (OSA), measured by polysomnography in
 normal weight patients with central obesity by body mass index (BMI) and waist hip ratio
 (WHR), with normal weight patients without central obesity by BMI and WHR.

 Evaluation of arterial stiffness and vascular age in normal weight patients with central
 obesity and in normal weight patients without central obesity.

 Determination of the exercise response characteristics in OSA patients.
Body composition (the distribution of adipose tissue) appears to be a risk factor for the
 prevalence of obstructive form of sleep apnea. The investigators expect a higher prevalence
 of this serious sleep pathology in normal weight patients with central obesity than in normal
 weight patient without central obesity. In normal weight patients with central obesity also
 endothelial dysfunctions, abnormal exercise response to dynamic load and abnormal circadian
 patterns of blood pressure and heart rate can be expected. There are theoretical assumptions
 for this hypothesis but relevant studies on sufficiently large samples of patients have not
 been done. The investigators will also compare the lipid profile in normal weight patients
 with central obesity with those of normal weight patients without central obesity.
Inclusion Criteria central obesity group:

 -  BMI 18.5 - 24.9 kg/m2 for both men and women

 -  WHR more than 0.9 for men and 0.85 for women

 -  no history of myocardial infarction, stroke, atrial fibrillation, previous diagnosis
 of OSA or its treatment.

 Inclusion Criteria without central obesity group:

 -  BMI 18.5 - 24.9 kg/m2 for men and women

 -  WHR selected from the lowest tertile of WHR distribution for both men and women

 Exclusion Criteria:

 -  acute infection

 -  known diagnosis of chronic renal or cardiac failure

 -  taking drugs that affect sleep (stimulants, hypnotics, antidepressants,
 antipsychotics, anxiolytics, antihistamines, corticosteroids, theophylline,
 anti-parkinsonic drugs, anticonvulsants, morphine-type analgetics)