Intravenous Lidocaine Randomized Comparative Effectiveness Trial
Intravenous Lidocaine Randomized Comparative Effectiveness Trial
This is a randomized, double-blind, emergency department based, comparative effectiveness
 study of two medication for acute abdominal pain: intravenous lidocaine and intravenous
 hydromorphone. Patients will be enrolled during an emergency department visit and followed
 throughout their emergency department course and then by telephone 7 days later.
Inclusion Criteria:Eligible patients are those who present to an ED for treatment of acute
 abdominal pain. Acute will be defined as pain for no more than seven days. At the time of
 enrollment, the ED treatment plan must include use of an intravenous opioid.

 Exclusion Criteria: Patients will be excluded from participation if they have cardiac
 conduction system impairment (QTc duration > 0.5s, QRS duration > 0.12s, or PR interval
 duration > 0.2s), known renal (CKD >2) or liver disease (Childs-Pugh B or greater), are
 hemodynamically unstable, as determined by the attending physician, are pregnant or
 breastfeeding, or have a known allergy to either medication. Patients will also be excluded
 if they have used prescription or illicit opioids within the previous week, or if they have
 a chronic pain disorder, defined as use of any analgesic medication on more days than not
 during the month preceding the acute episode of pain. Patients weighing < 60kg or > 120kg
 will be excluded.

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