Effects of Levothyroxine on Endothelial Function of Patients With Subclinical Hypothyroidism
Effects of Levothyroxine on Endothelial Function of Patients With Subclinical Hypothyroidism
Hypothyroidism is risk factor in atherosclerotic cardiovascular diseases, but there is a
 controversy in effect of subclinical hypothyroidism on cardiovascular diseases. We aim to
 estimate the relation between subclinical hypothyroidism and endothelial dysfunction and the
 effects of levothyroxine therapy on it. Patients with confirmed subclinical hypothyroidism by
 lab results will be randomized to two groups of treatment with one daily dose of 100 mg
 Levothyroxine or placebo. The flow-mediated dilation and intima media thickness are evaluated
 before and after the study.
Inclusion Criteria:

 -  age 18 to 65

 -  confirmed subclinical hypothyroidism

 Exclusion Criteria:

 -  receiving of other treatments for hypothyroidism

 -  patients with other major medical disorders

 -  smoking

 -  hyperlipidemia

 -  obesity