AGARIC Case Control Study
AGARIC Case Control Study
The aim of the study is to establish the existence of a relationship between the dietary
 intake of polyunsaturated fatty acids (PUFA) and the risk of colorectal cancer in humans,
 using 2 reliable and complementary biomarkers: the fatty acid-composition of lipids of the
 abdominal subcutaneous adipose tissue and the fatty acid composition of erythrocyte
 phospholipids.
Inclusion Criteria:

 CASES

 -  Patients aged ≥ 45 years

 -  with a first recently-diagnosed colorectal cancer

 -  due to undergo elective surgical resection with curative intent (in practice, stage I,
 II, III or IV if there was only one hepatic nodule that was resected with curative
 intent) in one of the 5 following digestive surgery units: CHU de Dijon, CHU de Nancy,
 CHU de Strasbourg, CHU de Reims et CHU and Besançon.

 -  who have given their informed consent

 CONTROLS

 -  Patients aged ≥ 45 years

 -  due to undergo surgery for a benign abdominal disease (sigmoid diverticulitis,
 appendectomy, hiatal hernia …)

 -  matched for abdominal site with cases for age (± 3 years), sex and hospital

 -  Who have given their informed consent

 Exclusion Criteria:

 CASES

 -  pre-operative anticancer treatment (chemo or radiotherapy)

 -  existence of visceral metastases except a single hepatic nodule resected with curative
 intent

 -  familial adenomatous polyposis and HNPCC syndrome (when suspected: inclusion after
 complementary tumor phenotype study: screening for microsatellite instability and/or
 immunohistochemistry study of the expression of DNA mismatch repair proteins.

 -  known inflammatory disease of the intestine (ulcerative colitis, Crohn's disease)

 -  personal history (recent or not) of colorectal cancer

 -  emergency treatment for the presenting complication (perforation, occlusion…)

 -  significant modification in dietary habits during the previous three months

 -  other evolving neoplastic disease

 -  psychic state incompatible with understanding the modalities and the aims of the study
 (notably patients under guardianship)

 -  pregnant or breast-feeding women

 CONTROLS

 -  personal history of cancer or adenomatous colorectal polyps,

 -  emergency intervention

 -  known inflammatory disease of the intestine (ulcerative colitis, Crohn's disease)

 -  personal history (recent or not) of colorectal cancer

 -  emergency treatment for the presenting complication (perforation, occlusion…)

 -  significant modification in dietary habits during the previous three months

 -  evolving neoplastic disease

 -  psychic state incompatible with understanding the modalities and the aims of the study
 (notably patients under guardianship)

 -  pregnant or breast-feeding women