Systemic Zinc Sulphate in Treatment of Recurrent Aphthous Ulcerations:A Doubleblind, Placebo Controled Study
Systemic Zinc Sulphate in Treatment of Recurrent Aphthous Ulcerations:A Doubleblind, Placebo Controled Study
Recurrent aphthous stomatitis (RAS) is one of the most common of oral mucosa diseases that
 affects approximately 20% of the general population. Despite the fact that clinical,
 pathologic and therapeutic feature of the disease has been comprehensively studied, the
 pathophysiology of aphthous ulcers remains incompletely understood.

 Zinc is a potent catalyst of wound healing and zinc deficiency may be a common cause of
 delayed tissue repair. Use of zinc sulfate in promotion wound healing and preservation of
 epithelial integrity advocated its possible use in the treatment or prevention of recurrent
 oral ulcers.

 The purpose of the present study was to determine of systemic zinc sulphate in the treatment
 of recurrent aphthous stomatitis.
Recurrent aphthous stomatitis (RAS) is a chronic inflammatory disease of man characterized by
 painful ulceration recurring with varying frequency. The pathophysiology of aphthous ulcers
 remains partly understood. The primary disorder appears to be the result of activation of the
 cell-mediated immune system. Aphthous ulcers may have abnormalities in cell communication and
 epithelial integrity. The diagnosis of aphthous ulcers is primarily clinical. Aphthous ulcers
 occur on areas of nonkeratinized mucosa of the mouth particularly the buccal mucosa, the
 labial mucosa, the floor of the mouth, the ventral surface of the tongue, and the soft
 palate. The treatment of recurrent aphthous stomatitis (RAS) still remains unclear and is
 based mainly on experimental data. The purpose of therapy include the management of pain and
 functional injury by suppressing inflammatory responses, in addition to reducing the
 frequency of recurrences or keeping away from the onset of new ulcers .Zinc has been
 identified as an important factor in repair of tissue.After considerable searching zinc was
 recognized as the beneficial impurity and a effective factor in healing .The goal of this
 study is to present the efficiency of dietary zinc supplements in the rate of Recurrent
 aphthous stomatitis healing.
Inclusion Criteria:

 1. A history of Recurrent aphthous stomatitis

 2. Patients who had symptoms such as burning sensation, pain

 3. Patients not on any immunosuppressive or immunomodulatory treatment .

 4. Patients of both sexes over 10 years with recurrent aphthous stomatitis

 5. Patients who gave written informed consent

 6. Patients who were willing for evaluation after therapy and every 1 month up to 5months

 Exclusion Criteria:

 1. Participants demonstrating drug consumption in the 7 past months

 2. pregnancy or lactation

 3. Any kind of localized or systemic disease, especially ulcerative colitis , chorn
 disease and Bechet's syndrome

 4. Smokers

 5. patients receiving immunosuppressive treatments or any kind of systemic or local drugs
 especially systemic antibiotics (in past 2 weeks ) and oral antihistamines( in past
 month ) were either eliminated or asked to discontinue their treatment for a minimum
 of one month before entering the investigation.