Clinic Trial to Evaluate the Safety and Immunogenicity of Combined Immunization of sIPV and DTaP
Clinic Trial to Evaluate the Safety and Immunogenicity of Combined Immunization of sIPV and DTaP
Eligible,healthy infants will be recruited and divided into 3 groups:(1)combined immunization
 of sIPV and DTaP group, (2) sIPV group and (3) DTaP group. After completing the two basic
 vaccine EPI procedures, the immunogenicity and safety of the combined immunization group and
 the individual vaccination groups will be compared and analyzed.
It is recommended by China Food and Drug Administration (CFDA) that studies on simultaneous
 immunization of Sabin-IPV and DTaP be carried out as soon as possible, and the immunogenicity
 and safety studies should also be conducted. Currently in China the vaccination schedules of
 sIPV and DTaP overlap at infants' 3rd and 4th months of age. In order to avoid the
 vaccination time conflict and explore the possibility of simultaneous vaccination, we design
 this clinical study of simultaneous vaccination of the two vaccines.

 To be specific, the subjects were divided into 3 groups. Group 1 : sIPV (1st, 2nd, and 3rd
 doses) and DTaP (1st, 2nd, and 3rd doses) were simultaneously inoculated at 3,4,5 months old
 ; Group 2 : received 1 dose of sIPV at 3,4,5 months old ; Group 3 : received 1 dose of DTaP
 at 3,4,5 months old . Blood sample would be collected both before vaccination and 28-40 days
 after the 3rd dose of vaccination. Neutralization antibody would also be detected to evaluate
 the seroprotection rates and antibody geometric mean concentrations. The safety of both
 immunization schedule will be monitored as well.
Inclusion Criteria:

 -  subjects aged 3 months old at the date of recruitment;

 -  with informed consent signed by parent(s) or guardians;

 -  parent(s) or guardians are able to attend all planned clinical appointments and obey
 and follow all study instructions;

 -  subjects have not been vaccinated with IPV vaccine, OPV vaccine, DTP vaccine and
 related vaccines;

 Exclusion Criteria:

 -  subject who has a medical history with Hypersensitiveness, eclampsia, epilepsy,
 cerebropathia and neurological illness;

 -  allergic to any ingredient of vaccine or with allergy history to any vaccine;

 -  subjects with immunodeficency or suspected impairment of immunologic function (e.g.
 caused by HIV), or subjects are in the process of immunosuppressor therapy(Taking
 orally injecting of steroid hormone);

 -  administration of immunoglobulins within 30 days prior to this study;

 -  acute febrile disease(temperature ≥ 37.0°C) or infectious disease;

 -  have a clearly diagnosed history of thrombocytopenia or other coagulopathy, may cause
 contraindications for subcutaneous injection;

 -  any serious chronic illness, acute infectious diseases, or respiratory diseases;

 -  severe cardiovascular disease, liver and kidney diseases or diabetes mellitus with
 complications;

 -  any kind of infectious, purulent, or allergic skin diseases;

 -  any other factor that makes the investigator determines the subject is unsuitable for
 this study.