Cavitation Ultrasound in Treatment of Patients With PCOS
Cavitation Ultrasound in Treatment of Patients With PCOS
The aim of the current work was to compare the efficacy of cavitation ultrasound, metformin
 or combination of both in obese women with polycystic ovary syndrome (PCOS) regarding
 clinical pregnancy rate, ovulation rate, insulin resistance, serum testosterone level, lipid
 profile.
Polycystic ovary syndrome (PCOS) affects 5 to 10% of women of childbearing age and is the
 most common cause of anovulatory infertility. Common clinical manifestations include
 menstrual irregularities and signs of androgen excess such as hirsutism, acne, and alopecia.
 Metformin, a biguanide, is the most widely used drug for the treatment of type 2 diabetes
 worldwide. Its primary action is to inhibit hepatic glucose production, but it also increases
 the sensitivity of peripheral tissues to insulin. The increase in insulin sensitivity, which
 contributes to the efficacy of metformin in the treatment of diabetes, has also been shown in
 non diabetic women with the polycystic ovary syndrome.In women with PCOS, long-term treatment
 with metformin may increase ovulation, improve menstrual cyclicity, and reduce serum androgen
 levels; the use of metformin may also improve hirsutism. If published data on the effects of
 metformin in the prevention of diabetes can be extrapolated to women with the PCOS, then the
 drug may actually retard progression to glucose intolerance in affected women, as reported in
 a small, retrospective study. Ultrasonic vibrations spread in the form of a wave in medium
 such as a liquid or a solid. When the particles of an elastic medium are under ultrasonic
 vibration, they act continuously in only one direction. The lipolytic range of ultrasounds is
 30-70 Kilohertz (KHz), and the best effects are obtained in a range between30-35 KHz. The
 depth of the treatment in the tissues is generally2-3 cm, to avoid muscles involvement.
 Biological effects of ultrasounds on adipocytes are: micro-mechanical, thermal,
 micro-streaming and cavitation. Cavitation ultrasound means that ultrasounds produce an
 alternation of decompression and compression waves in a fluid media which progressively
 increase the tension of the adipocyte until it implodes and frees the emulsified fat. The aim
 of the current work was to compare the efficacy of cavitation ultrasound, metformin or
 combination of both in obese women with polycystic ovary syndrome (PCOS) regarding clinical
 pregnancy rate, ovulation rate, insulin resistance, serum testosterone level, lipid profile.
Inclusion Criteria:

 -  Obese infertile polycystic ovarian syndrome (PCOS) women

 Exclusion Criteria:

 -  Women 40 years or older

 -  Women using fertility treatments, oral contraceptives or other confounding medications
 during the last 3 months

 -  Smokers or with history of general diseases like cardiovascular, liver, kidney or
 respiratory disease, diabetes, uncontrolled hypertension, or malignancy