Outcomes of Transrenal Artery Perfusion Versus Transrenal Vein Perfusion Using LifePort for Deceased Donor Kidney Transplantation
Outcomes of Transrenal Artery Perfusion Versus Transrenal Vein Perfusion Using LifePort for Deceased Donor Kidney Transplantation
The main objective of this study is to compare the outcomes of transrenal artery perfusion
 versus transrenal vein perfusion using LifePort for deceased donor kidney transplantation.
 Patients registered in the National Dialysis and Transplant Registry awaiting deceased donor
 kidney transplantation were included. Delayed graft function (DGF) or primary nonfunction
 (PNF) may occur after deceased donor kidney transplantation. Compared with static cold
 storage, the application of LifePort can significantly reduce the incidence of DGF and PNF in
 deceased donor kidney transplantation. Transrenal artery perfusion is currently the
 mainstream but confronts multiple renal arteries, resulted in prolonged cold ischemia time.
 Transrenal vein perfusion is expected to be a solution. However, whether the clinical
 outcomes of transrenal vein perfusion is inferior to transrenal artery perfusion remains
 unknown. In this study, values of urine volume and creatinine, incidence and duration of DGF,
 and incidence of PNF within 1 week after surgery are recorded and compared between the
 transrenal artery perfusion group and the transrenal vein perfusion group. Monthly eGFR and
 creatinine values, the incidence of acute rejection within 1 year after transplantation and
 1-year graft and patient survival are also recorded and compared.
Inclusion Criteria:

 1. Adult recipients older than 18 years;

 2. Patients diagnosed with end-stage renal diseases and volunteered to register in the
 Transplant and Dialysis Registry of China awaiting for deceased donor kidney
 transplantation;

 3. First single kidney transplantation;

 4. The recipients can understand the purpose and risk of deceased kidney transplantation
 and sign informed consent;

 5. Ethics committee approved.

 Exclusion Criteria:

 1. Patients less than 18 years old, or more than 65 years old;

 2. Patients who receive multiple organ transplants;

 3. Diagnosed with malignancy or had a history of malignancy in the past 5 years;

 4. non-kidney transplantation history.