Dose Ranging Study of RPL554 in Chronic Obstructive Pulmonary Disease (COPD) Patients
Dose Ranging Study of RPL554 in Chronic Obstructive Pulmonary Disease (COPD) Patients
The study investigates the effect of 4 weeks of twice daily treatment of four different doses
 of RPL554 (a phosphodiesterase [PDE]3/4 inhibitor) or placebo in patients with moderate to
 severe chronic obstructive pulmonary disease (COPD). Patients will be equally allocated to
 one of the five treatment options.
RPL554 is a dual inhibitor of PDE3 and PDE4 which are known to have a role in modulating the
 inflammatory airway response in respiratory diseases, including COPD. PDE3 inhibitors act as
 bronchodilators whilst PDE4 inhibitors have anti-inflammatory properties and there is also
 evidence to suggest that combined inhibition of PDE3 and PDE4 can have additive or
 synergistic anti-inflammatory and bronchodilator effects. PDE4 inhibitors (administered
 orally) have, however been associated with unfavorable gastrointestinal side effects such as
 nausea, emesis, diarrhea, abdominal pain, loss of appetite and weight loss. Dual PDE3/PDE4
 inhibitors (administered by inhalation) have exhibited both bronchodilator and
 anti-inflammatory actions, with a more favorable side effect profile. It is plausible that
 increased efficacy with reduced side effects may be achievable with administration of a dual
 PDE3/4 inhibitor by the inhaled route compared to orally administered PDE3 or PDE4
 inhibitors.

 The purpose of this study is to investigate the dose response of RPL554 in patients with COPD
 over 4 weeks. This length of time should allow for study of the bronchodilator response,
 measured predominantly by the peak forced expiratory volume in one second (FEV1), and the
 anti-inflammatory response, as measured predominantly by trough FEV1.
Inclusion Criteria:

 -  Provide informed consent

 -  Male or female aged 40 to 75 years

 -  Meeting specified contraception requirements

 -  12-lead electrocardiogram with heart rate 50-90 beats per minute, QT interval
 corrected using Fridericia's formula (QTcF) ≤450 msec (males) or ≤470 msec (females),
 QRS interval ≤120 msec, PR interval ≤200 msec and no clinically significant
 abnormalities

 -  Capable of complying with all study restrictions and procedures, including ability to
 use the study nebulizer correctly.

 -  Body mass index (BMI) 18 to 35 kg/m2 and minimum weight 45 kg.

 -  COPD diagnosis with symptoms compatible with COPD for at least 1 year

 -  Clinically stable COPD in the previous 4 weeks

 -  Ability to perform acceptable and reproducible spirometry.

 -  Post-bronchodilator spirometry at screening must demonstrate FEV1/forced vital
 capacity (FVC) ratio of ≤0.70 and FEV1 must be ≥40 % to ≤80% of predicted normal

 -  Chest X-ray (posterior-anterior) at screening, or chest X-ray, magnetic resonance
 imaging (MRI) or computed tomography (CT) scan in the last 12 months, showing no
 abnormalities which are both clinically significant and unrelated to COPD.

 -  Meet the concomitant medication restrictions and be expected to do so for the rest of
 the study.

 -  Current and former smokers with a smoking history of ≥10 pack years.

 -  Capable of withdrawing long acting bronchodilators until the end of the treatment
 period, and short acting bronchodilators for 8 hours prior to administration of study
 medication.

 Exclusion Criteria:

 -  A history of life-threatening COPD including Intensive Care Unit admission and
 requiring intubation.

 -  COPD exacerbation requiring oral steroids in the previous 3 months

 -  A history of one or more hospitalizations for COPD in the previous 6 months

 -  Lower respiratory tract infection treated with antibiotics in the previous 3 months

 -  Evidence of cor pulmonale or clinically significant pulmonary hypertension.

 -  Patients with a current diagnosis of asthma, active tuberculosis, lung cancer,
 bronchiectasis, sarcoidosis, lung fibrosis, interstitial lung diseases, sleep apnea,
 known alpha-1 antitrypsin deficiency or other active pulmonary diseases.

 -  Previous lung resection or lung reduction surgery.

 -  Oral therapies for COPD (e.g. oral steroids, theophylline, and roflumilast) in the
 previous 3 months and throughout the study.

 -  Pulmonary rehabilitation, unless such treatment has been stable from 4 weeks prior to
 Visit 1) and remains stable during the trial.

 -  A history of, or reason to believe a subject has, drug or alcohol abuse in the
 previous 3 years.

 -  Received an experimental drug within 30 days or five half-lives of the first dose

 -  Prior exposure to RPL554.

 -  Women who are pregnant or breast-feeding.

 -  Patients with a history of current uncontrolled disease that the Investigator believes
 are clinically significant.

 -  myocardial infarction in the previous 6 month; congestive heart failure, a history of
 unstable or uncontrolled hypertension, or has been diagnosed with hypertension in last
 3 months.

 -  Use of oral beta blockers.

 -  Major surgery (requiring general anesthesia) in the previous 6 weeks, lack of full
 recovery from surgery at screening, or planned surgery through the end of the study.

 -  History of malignancy of any organ system within 5 years, with the exception of
 localized skin cancers (basal or squamous cell).

 -  Clinically significant abnormal values for safety laboratory tests

 -  Significant non-compliance in previous investigational studies or with prescribed
 medications.

 -  Requirement for oxygen therapy, even on an occasional basis.

 -  Known hypersensitivity to RPL554 or its excipients/components.

 -  Abnormal clinically significant 12 lead Holter findings,

 -  Any other reason that the Investigator considers makes the subject unsuitable to
 participate.