Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trial
Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trial
This phase Ib trial determines if samples from a patient's cancer can be tested to find
 combinations of drugs that provide clinical benefit for the kind of cancer the patient has.
 This study is also being done to understand why cancer drugs can stop working and how
 different cancers in different people respond to different types of therapy.
PRIMARY OBJECTIVE:

 I. To determine the feasibility of implementing an individualized treatment strategy for
 advanced solid tumor and hematological malignancies based upon a comprehensive assessment of
 tumor and patient characteristics.

 SECONDARY OBJECTIVES:

 I. To describe the tolerability of implementing an individualized treatment strategy,
 particularly by measuring unanticipated toxicity associated with the administration of
 different combinations of two therapeutic agents given to an individual participant.

 II. To assess the duration of treatment for participants receiving Serial Measurements of
 Molecular and Architectural Responses to Therapy (SMMART)-PRIME Therapy #1.

 III. To determine overall survival of participants with advanced solid tumors and
 hematological malignancies.

 IV. To determine the time to decline in a participant's ability to perform activities of
 daily living.

 EXPLORATORY OBJECTIVES:

 I. To measure quality of life among enrolled participants. II. To evaluate immune-mediated
 tumor response among participants receiving an immunomodulatory study drug.

 III. To determine the rates of response and benefit to SMMART-PRIME Therapy #1, as an
 individualized treatment strategy for participants with advanced solid tumor and
 hematological malignancies.

 IV. To determine the progression-free and disease-free survival of participants with advanced
 solid tumors and hematological malignancies.

 OUTLINE:

 TUMOR BIOPSY: Patients undergo collection of tissue samples. Clinical analytics are performed
 on the samples and analyzed by a clinical tumor board to recommend a treatment option based
 on those analytics. The findings from these Clinical Study Analytics are intended to provide
 the basis for selection of two drugs that, when administered in combination, provide an
 optimal and individualized treatment approach. This may or may not include a SMMART-PRIME
 treatment. The decision to initiate any SMMART-PRIME Therapy ultimately resides with the
 treating physician in conjunction with the study participant.

 SMMART-PRIME TREATMENT: Patients receive a combination of 2 drugs (Drug A and Drug B,
 selected from interventions below). Doses will be escalated within individual patients over
 time. As described in detail below, escalation will occur on a monthly basis and is
 anticipated to occur as follows: first month -- 100% Food and Drug Administration (FDA)
 approved dose Drug A + 25% FDA approved dose Drug B; second month -- 100% dose Drug A + 50%
 dose Drug B; third month -- 100% dose Drug A + 100% dose Drug B. All dose-escalations will be
 reviewed and approved by an independent consultant outside of Oregon Health & Science
 University (OHSU).

 Treatment will continue for up to the end of 6 treatment cycles (cycle length is between
 21-28 days) in the absence of disease progression or unacceptable toxicity. Patients whose
 treatment is discontinued as a result of excess toxicity or lack of efficacy may switch to a
 different combination of drugs. Beyond six cycles, participants will be considered
 off-protocol directed treatment, and will move into long term follow-up.

 After completion of study treatment, patients are followed for up to 5 years.
Key Inclusion Criteria:

 -  Ability to understand and the willingness to sign a written informed consent document

 -  Participants, both men and women, must agree to use an adequate method of
 contraception prior to study entry, for the duration of study participation, and for 4
 months after completion of study

 -  Women of childbearing potential must have a negative serum or urine pregnancy test
 within 14 days prior to start of study drug administration

 -  Patients must have a histologically or cytologically-confirmed metastatic solid tumor
 or hematological malignancy that has progressed as follows:

 -  Patients with a solid tumor must have metastatic disease and have progressed on
 at least 1 line of established therapy that is known to provide clinical benefit,
 or for whom no standard curative therapy exists. Participants with newly
 diagnosed, unresectable, locally-advanced or metastatic pancreatic adenocarcinoma
 and are beginning first-line treatment with a course of chemotherapy are eligible
 OR

 -  Participants must have a hematological malignancy that is advanced, relapsed, or
 refractory to at least 1 line of established therapy that is known to provide
 clinical for the treatment of their disease. Hematological disease included in
 this study are as follows:

 -  Acute myelogenous leukemia (AML), or

 -  Myelodysplastic syndrome (MDS), or

 -  MDS/myeloproliferative neoplasms (MDS/MPN), or

 -  Primary myelofibrosis (PMF)

 -  Acute lymphoblastic leukemia (ALL)

 -  Chronic myelogenous leukemia (CML)

 -  Non-Hodgkin lymphoma (NHL) or Hodgkin's disease (HD)

 -  Chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL)

 -  Multiple myeloma (MM)

 -  Participants with a metastatic solid tumor or advanced hematological malignancy whom,
 due to medical issues cannot receive standard therapy shown to prolong survival, will
 be eligible, if other eligibility criteria are met

 -  Patients with a metastatic solid tumor or advanced hematological malignancy that
 actively refuse chemotherapy that is considered standard treatment for their
 cancer, despite being informed by the investigator about the treatment options,
 are eligible for this study on a case-by-case basis (in consultation with the
 principal investigator [PI]). Potential participants actively refusing
 chemotherapy must have had progression or refractory disease prior to starting
 study treatment, and their refusal must be documented

 -  Participants must have measurable disease:

 -  Patients with solid tumors must have measurable disease as defined by Response
 Evaluation Criteria in Solid Tumors (RECIST) version (v) 1.1. At least one lesion
 that can be accurately measured in at least one dimension (longest diameter to be
 recorded for non-nodal lesions and short axis for nodal lesions) as >= 20 mm with
 conventional techniques or as >= 10 mm with spiral computed tomography (CT) scan,
 per RECIST (v1.1)

 -  Note: Participants with lesions on a bone scan that are considered distinctly
 metastatic will also be included

 -  Patients with lymphoma must have at least one non-irradiated tumor mass > 15 mm
 (long axis of lymph node) or > 10 mm (short axis of lymph node or extranodal
 lesions) on spiral CT-scan

 -  Patients with CLL must have presence of radiographically measurable
 lymphadenopathy (defined as the presence of >= 1 nodal lesion that measures >=
 2.0 cm in the longest diameter [LD] and >= 1.0 cm in the longest perpendicular
 diameter [LPD] as assessed by CT or magnetic resonance imaging [MRI])

 -  Patients with MM must have at least one of the following: serum monoclonal
 component > 1 g/dL (IgG), or > 0.5 g/dL (IgA), or Bence-Jones (BJ) proteinuria >
 200 mg/24 hour, or measurable plasmacytoma (not previously irradiated)

 -  Participants with a hematological malignancy must have their bone marrow biopsy and
 aspirate reviewed at Oregon Health & Science University (OHSU)

 -  Participants with a solid tumor must have lesions meeting the above criteria also and
 must be amenable to biopsy procedures performed per institutional standards

 -  Participants must not currently be receiving any other investigational agents

 -  Participants must have Eastern Cooperative Oncology Group (ECOG) performance status =<
 2 and a physician assessed life expectancy of >= 6 months

 -  Absolute neutrophil count (ANC) >= 1,500/mcL (at time of registration and within 4
 weeks prior to initiating on-protocol treatment)

 -  Waived for those with hematological malignancy; and may be waived on a
 case-by-case basis for patient populations recognized to have normal baseline
 values below this level

 -  Platelets >= 100,000/mcL (at time of registration and within 4 weeks prior to
 initiating on-protocol treatment)

 -  Waived for those with hematological malignancy

 -  Hemoglobin >= 9 g/dL or >= 5.6 mmol/L (at time of registration and within 4 weeks
 prior to initiating on-protocol treatment)

 -  Waived for those with hematological malignancy

 -  Creatinine =< 1.5 x upper limit of normal (ULN) OR measured or calculated creatinine
 clearance (glomerular filtration rate [GFR] can also be used in place of creatinine or
 creatinine clearance [CrCl]) >= 60 mL/min/1.73 m^2 for participants with creatinine
 levels > 1 x institutional ULN (at time of registration and within 4 weeks prior to
 initiating on-protocol treatment)

 -  Waived for those with hematological malignancy; and may be waived on a
 case-by-case basis for patient populations recognized to have normal baseline
 values below this level

 -  Total bilirubin =< 1.5 x ULN OR direct bilirubin =< ULN for participants with total
 bilirubin levels > 1.5 x ULN (at time of registration and within 4 weeks prior to
 initiating on-protocol treatment)

 -  Creatinine clearance should be calculated per institutional standard. For
 participants with a baseline calculated creatinine clearance below normal
 institutional laboratory values, a measured baseline creatinine clearance should
 be determined. Individuals with higher values felt to be consistent with inborn
 errors of metabolism will be considered on a case-by-case basis

 -  Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT]) and
 alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 3 x
 ULN (at time of registration and within 4 weeks prior to initiating on-protocol
 treatment)

 -  International normalized ratio (INR) or prothrombin time (PT) =< 1.5 x ULN unless
 participant is receiving anticoagulant therapy as long as PT or partial thromboplastin
 time (PTT) is within therapeutic range of intended use of anticoagulants (at time of
 registration and within 4 weeks prior to initiating on-protocol treatment)

 -  Activated partial thromboplastin time (aPTT) or PTT =< 1.5 x ULN unless participant is
 receiving anticoagulant therapy as long as PT or PTT is within therapeutic range of
 intended use of anticoagulants (at time of registration and within 4 weeks prior to
 initiating on-protocol treatment)

 -  Body mass index (BMI) > > 16.0 and < 35.0 kg/m^2 (at time of registration and within 4
 weeks prior to initiating on-protocol treatment)

 -  Participants with a BMI of >= 30.0 will use ideal body weight indices in
 calculating the delivery of agents that are dosed based upon body surface area
 (i.e., mg agent/meter squared) or weight (i.e., mg agent/kg body weight)

 -  Any prior therapy, radiotherapy (except palliative radiation therapy of 30 Gy or
 less), or major surgery must have been completed >= 4 weeks prior to start of study
 treatment. All adverse events due to prior therapy must have resolved to a grade 1 or
 better (except alopecia and lymphopenia for all disease cohorts, and hematologic
 toxicity for those with a hematological malignancy) by start of treatment. Palliative
 radiation therapy must have been completed at least 2 weeks prior to start of
 treatment. The radiotherapy must not be to a lesion that is included as measurable
 disease

 -  Additional cancer-specific inclusion criteria must also be met

 Key Exclusion Criteria:

 -  Participants with metastases to the central nervous system that are considered
 uncontrolled and/or were diagnosed within the past 4 weeks of screening for this study

 -  Participants cannot have an active malignancy of another cancer. Those with a history
 of prior malignancy will be considered on a case-by-case basis. Guiding examples for
 those who can be enrolled include: individuals who have been disease free for > 5
 years; individuals who are considered to have a high likelihood of being cured (e.g.,
 prior history of stage 1 rectal cancer and currently otherwise disease free);
 adequately treated localized non-melanomatous skin cancer

 -  Participants cannot be on other forms of anti-cancer therapy at the same time, except
 as described within this protocol. There must be at least a washout period that
 accounts for 5 half-lives (or >= 21 days, whichever is longer) of last therapy

 -  Participants with prostate cancer (PCa) will continue treatment with androgen
 deprivation therapy, either by prior castration or treatment with luteinizing
 hormone-releasing hormone (LHRH) antagonists or agonists, as is standard practice

 -  Participants with breast cancer (BCa) who are HER2 positive may continue to
 receive anti-HER2 therapy per standard practice guidelines, while participants
 who are hormone receptor positive may continue to receive hormone therapy per
 standard practice guidelines

 -  Participants with a hematological malignancy may continue to receive hydroxyurea
 or other hypomethylating agent for two cycles of SMMART-PRIME therapy, as
 described in this protocol

 -  Uncontrolled intercurrent illness including, but not limited to, symptomatic
 congestive heart failure, unstable angina pectoris, serious cardiac arrhythmia,
 myocardial infarction within 6 months prior to enrollment, New York Heart Association
 (NYHA) class III or IV heart failure

 -  Chronic graft versus host disease (GVHD) or on immunosuppressive therapy for the
 control of GVHD

 -  Participants with uncontrolled infection will not be enrolled until infection is
 treated

 -  Participant is seropositive with human immunodeficiency virus (HIV) or has active
 infection with hepatitis B virus (HBV) or hepatitis C virus (HCV)

 -  HIV-infected patients on effective anti-retroviral therapy with undetectable
 viral load within 6 months are eligible for this trial

 -  For patients with evidence of chronic HBV infection, the HBV viral load must be
 undetectable on suppressive therapy, if indicated

 -  Individuals with a history of HCV infection must have been treated and cured. For
 patients with HCV infection who are currently on treatment, they are eligible if
 they have an undetectable HCV viral load

 -  Participants with medical conditions, inclusive of psychiatric, that in the opinion of
 the investigators would jeopardize the patient or the study will be excluded

 -  Participants that are pregnant or breast feeding

 -  ON-TREATMENT: Individuals that have medical and/or psychiatric conditions that in the
 opinion of investigators would jeopardize participant safety or study integrity if
 they were to receive on-study treatment will not proceed further treatment and will be
 removed from study

 -  ON-TREATMENT: If performance status is ECOG > 2

 -  ON-TREATMENT: History of allergic reaction to a recommended study agent or its
 excipients

 -  Additional cancer-specific exclusion criteria requirements