Caffeine in Children With Obstructive Sleep Apnea, Dose Response Study
Caffeine in Children With Obstructive Sleep Apnea, Dose Response Study
The aim of this study is to evaluate whether a smaller dose of caffeine sodium benzoate 10
 mg/kg IV is as effective as 20 mg/kg IV in decreasing the number of children who develop post
 extubation adverse upper airway respiratory events compared to placebo.
Institutional approval and written informed consent from parents or guardians of healthy
 children, with obstructive sleep apnea (OSA) and/or with increased end-tidal C02 (sleep
 related hypoventilation, obstructive hypoventilation or sustained alveolar hypoventilation),
 confirmed with sleep study, scheduled for elective outpatient or inpatient
 adeno-tonsillectomy at our hospital, will be obtained. The study will be prospective,
 randomized, double blinded and placebo controlled. A computer generated randomization list
 will be used, and the study will be registered with clinical.trials.gov. Written child assent
 will be obtained from children 7 years and older. Copies of a flyer and an explanation of the
 study will be provided at the office of all the pediatric ENT surgeons who practice at the
 Memorial Hermann Hospital OR. The investigators will communicate with the nurses at the
 surgeons' office and ask them to give the flyer with an explanation of the study to the
 parents and children on the day they schedule the surgery. The flyer with an explanation of
 study will be sent to IRB for review and approval. A research assistant will invite parents
 or guardians in the DSU unit, anesthesia clinic or on the floor to allow their children to be
 part of the study. Children with OSA and/or increased end tidal C02 (sleep related
 hypoventilation, obstructive hypoventilation or sustained alveolar hypoventilation), 2-12
 years of age, and both genders will be eligible to be part of the study. OSA and its severity
 will be diagnosed by a preoperative polysomnography. Children with compromised
 cardiovascular, pulmonary or renal function, those with congenital syndromes, sickle cell
 disease, history of seizures and those receiving theophylline will be excluded.
Inclusion Criteria:

 -  Children with OSA and/or increased end tidal C02 (sleep related hypoventilation,
 obstructive hypoventilation or sustained alveolar hypoventilation), 2-12 years of age,
 and both genders will be eligible to be part of the study. OSA and its severity will
 be diagnosed by a preoperative polysomnography.

 Exclusion Criteria:

 -  Children with compromised cardiovascular, pulmonary or renal function, those with
 congenital syndromes, sickle cell disease, history of seizures and those receiving
 theophylline will be excluded.