Tobacco Dependence in Alcoholism Treatment (Nicotine Patch/Naltrexone)
Tobacco Dependence in Alcoholism Treatment (Nicotine Patch/Naltrexone)
The purpose of this study is to determine the effectiveness of naltrexone (Revia) or matched
 placebo combined with nicotine patch (Nicotrol) or placebo patch using a 2x2 design in
 reducing drinking and smoking in patients with both nicotine and alcohol dependence.
Eligible individuals will be randomly assigned to a 12-week trial of a fixed daily dose of
 either naltrexone (Revia) and nicotine replacement patch or placebos. All individuals will
 receive weekly coping skills and smoking-cessation behavioral therapy. Followup interviews
 will be conducted 3 and 6 months after treatment to determine smoking and drinking status and
 persistence of any dependence symptoms.
Inclusion Criteria:

 -  Meets criteria for alcohol dependence and nicotine dependence.

 -  Expresses a desire to cut down or stop drinking and smoking.

 Exclusion Criteria:

 -  Currently meets criteria for dependence on substances other than alcohol and nicotine.

 -  Any history of opiate dependence or evidence of current opiate use.

 -  Significant medical disorders that will increase potential risk or interfere with
 study participation.

 -  Liver function tests more than 3 times normal or elevated bilirubin.

 -  Females who are pregnant, nursing, or not using a reliable method of birth control.

 -  Meets criteria for a major psychiatric disorder and is in need of or currently
 undergoing drug therapy.

 -  Inability to understand and/or comply with the provisions of the protocol and consent
 form.

 -  Treatment with an investigational drug during the previous month.

 -  Chronic treatment with any narcotic-containing medications during the previous month.

 -  Sensitivity to drug as evidenced by adverse drug experiences especially with narcotic-
 containing analgesics or opioid antagonists.

 -  Current treatment with disulfiram (Antabuse) or nicotine replacement therapy.

 -  More than 6 weeks of abstinence.