Effects of Proton Pump Inhibitors on Kidney Transplant Recipients
Effects of Proton Pump Inhibitors on Kidney Transplant Recipients
Use of proton pump inhibitors (PPIs) is quite common among renal transplant recipients and
 reduced kidney functions and hypomagnesemia with the use of PPIs have been reported. In this
 study, investigation of the effects of PPI use on the outcome of kidney transplant recipients
 is aimed.
Use of proton pump inhibitors (PPIs) is frequent among renal transplant recipients due to the
 common use of glucocorticoids in immunosuppresive regimens after transplantation. Reduced
 kidney functions and hypomagnesemia with the use of PPIs have been reported in various
 patient populations. However, few studies examined the effects of PPIs on kidney transplant
 recipients. Therefore, the aim of this study is to investigate the effects of PPI and/or
 histamine H2 receptor antagonist use on serum magnesium levels, allograft functions and
 survival in kidney transplant recipients.
Inclusion Criteria:

 -  Kidney transplant recipients who used only proton pump inhibitors and did not use
 histamine H2 receptor antagonists (Only PPI).

 -  Kidney transplant recipients who used histamine H2 receptor antagonists and did not
 use proton pump inhibitors (Only H2RA).

 -  Kidney transplant recipients who used both proton pump inhibitors and histamine H2
 receptor antagonists (PPI and H2RA).

 -  Kidney transplant recipients who used neither proton pump inhibitors nor histamine H2
 receptor antagonists (No Acid Suppressive Treatment).

 Exclusion Criteria:

 -  Patients who are unwilling or unable to consent.