Effects of Parathyroidectomy on Cardiovascular Risk Factors in Primary Hyperparathyroidism
Effects of Parathyroidectomy on Cardiovascular Risk Factors in Primary Hyperparathyroidism
Primary hyperparathyroidism (PHPT) is associated with increased cardiovascular morbidity. The
 benefit of surgical treatment in this respect is unclear.

 This study was performed to evaluate the impact of parathyroidectomy (PTX) on cardiovascular
 risk profile.
Patients with primary hyperparathyroidism (PHPT) have been shown to have an increased
 morbidity and mortality mainly due to cardiovascular disease. The precise mechanism of
 cardiovascular disease in PHPT is not well understood and probably multifactorial. Functional
 or structural alterations of vascular endothelial and smooth muscle cells may impair the
 vascular reactivity and lead to accelerated atherogenesis. Several cardiovascular risk
 factors such as obesity, hypertension, insulin resistance and hyperlipidemia are more
 prevalent in PHPT compared with controls.Patients with severe form of PHPT had a greater
 probability of metabolic syndrome (MS) and insulin resistance than patients with mild PHPT
 and eucalcemic subjects. Although the excess in cardiovascular mortality is significantly and
 independently related to serum calcium, the connection between the biochemical disturbances
 and the cardiovascular disorders in PHPT patients is not necessarily a cause-and-effect
 relationship. Indeed, the impact of surgical cure of hyperparathyroidism on cardiovascular
 risk factors and mortality is controversial. Some studies suggest that hypertension,
 dyslipidemia, and derangement of glucose metabolism improve after removal of overactive
 parathyroid tissue. Others have shown that cardiovascular risk markers remained unaltered
 after parathyroidectomy (PTX).

 The aim of this study was to evaluate whether successful PTX is associated with decreased
 cardiovascular risk. We investigated indices of metabolic syndrome and insulin resistance as
 well as various cardiovascular risk factors in patients with manifest PHPT before and one
 year after successful PTX.
Inclusion Criteria:

 -  Patients with primary hyperparthyroidism

 Exclusion Criteria:

 -  Individuals with known diabetes mellitus,coronary heart disease, stroke