Prospective Study of Quality of Life in Non-small Cell Lung Cancer (NSCLC) Patients Treated With/Without Postoperative Radiotherapy
Prospective Study of Quality of Life in Non-small Cell Lung Cancer (NSCLC) Patients Treated With/Without Postoperative Radiotherapy
The patients from 12 centers were included into the study. pN2 patients received PORT, pN1
 patients did not. PORT was 3D-planned and consisted in 54-56 Gy in 27-28 fractions. One month
 after surgery, all patients completed EORTC QLQ C-30 questionnaires and had pulmonary
 function tests (PFT); cardiopulmonary symptoms were assessed by modified LENT-SOM score. Two
 years after, all patients free of disease repeated the same examinations. Changes in QLQ,
 LENT-SOM score and the results of PFT were compared for patients receiving and not PORT.
Inclusion Criteria:

 -  complete resection by lobectomy, bi-lobectomy or pneumonectomy of NSCLC,

 -  pN1 or pN2 disease,

 -  signed informed consent for participation in the study,

 -  Karnofsky Performance Status (KPS) higher than 70%.

 Exclusion Criteria:

 -  presence of distant metastases,

 -  N2 diagnosed before surgery in imaging and/or mediastinoscopy,

 -  previous radiotherapy to the chest,

 -  no or inadequate mediastinal nodal dissection ,

 -  FEV1 after surgery lower than 1.0 liter,

 -  any active infectious process (including fistula formation) in the chest