Chinese PD-GBA Registry
Chinese PD-GBA Registry
The purpose of the Chinese Parkinson's disease with GBA variants Registry (CPD-GBAR) is to
 develop a database of patients of Parkinson's disease with Glucocerebrosidase (GBA) gene
 variants in mainland China.
Parkinson's disease (PD) is the second most common disorder among neurodegenerative diseases.
 GBA gene variants such as L444P can influence the risk of developing PD and these variants
 have the greatest impact on PD susceptibility among all the PD related gene variants yet
 discovered. The investigators aim to establish a database of PD with GBA variants and
 characterize the clinical manifestation of these patients in mainland China.

 Method:

 1. Peripheral blood from patients has been tested to have GBA gene variants.

 2. Clinical manifestation will be measured by scales and neurological tests. Standard
 scales include: Unified Parkinson's Disease Rating Scale(UPDRS), Hoehn-Yahr stages,
 Non-Motor Symptoms Scale (NMSS), mini-mental state examination (MMSE), Parkinson disease
 sleep scales (PDSS), Rapid Eye Movement Sleep Behaviour Disorder Questionnaire(RBDQ-HK),
 Epworth Sleepiness Scale (ESS), Rome III functional constipation scale, the Scale for
 Outcomes in PD for Autonomic Symptoms (SCOPA-AUT), Parkinson Fatigue Scale (PFS),
 Cambridge-Hopkins Restless Legs Syndrome questionnaire (CHRLSq), Hyposmia rating
 scale(HRS), Hamilton depression scale, the 39-item Parkinson's Disease
 Questionnaire(PDQ-39), Freezing of gait scale(FOG), dyskinesia related scales,
 Wearing-off scale(WO).

 3. The investigators will also exam the blood biomarkers of PD such as uric acid and
 peripheral inflammatory markers.
Inclusion Criteria:

 -  Patients diagnosed with PD by the United Kingdom Parkinson's Disease Society Brain
 Bank clinical diagnostic criteria or other standard criteria; PD patients detected
 with GBA gene variants.

 Exclusion Criteria:

 -