Collection of Additional Data Followed the Study IFM 2013-04
Collection of Additional Data Followed the Study IFM 2013-04
Collection of retrospective additional data (survival, biological, disease response data)
 following the study IFM 2013-04.
Patients newly diagnosed with symptomatic Multiple Myeloma (MM) patient

 1. - 18 ≤ age < 66 years

 2. - Eastern Cooperative Oncology Group Performance Status of 0, 1 or 2

 3. - Patients must be eligible for Autologous Stem Cell Transplantation

 4. - Patients must have measurable disease by serum M-protein ≥ 10 g/L and/or urine
 M-protein ≥200mg/day

 5. - Female patients of child-bearing potential (FCBP):

 -  Must agree to have medically supervised pregnancy tests prior to starting study
 and every 21 days, including 4 weeks after the end of study treatment. This
 applies even if the patient practices complete and continued sexual abstinence.

 -  Must agree to use and be able to comply with effective contraception without
 interruption, 28 days prior to starting study drug, during the study therapy
 (including during periods of dose interruptions), and for 28 days after
 discontinuation of study therapy.

 6. - Male Patients:

 -  Must agree to use a condom during sexual contact with a FCBP, throughout study
 drug therapy, during any dose interruption and for one week after discontinuation
 of study therapy

 -  Must agree to not donate semen during study drug therapy and for one week after
 discontinuation of study therapy

 7. - All patients must:

 -  Agree to abstain from donating blood while taking study drug therapy and for one
 week after discontinuation of study drug therapy

 -  Agree not to share study medication with another person.

 8. - Patients must be capable of giving informed consent

 9. - Patients must be affiliated with French social security system

 Exclusion Criteria:

 1. - Asymptomatic Multiple myeloma

 2. - Non-secretory Multiple myeloma

 3. - Proven AL-amyloidosis

 4. - Age ≥ 66 years old

 5. - Prior or current systemic therapy for Multiple myeloma, including steroids (except
 for emergency use of a 4-day block of dexamethasone before randomization, maximum
 total dose allowed 160 mg)

 6. - Radiation therapy in the 2 weeks preceding randomization

 7. - National Cancer Institute grade ≥ 2 peripheral neuropathy

 8. - Haemoglobin < 8g/dL

 9. - Absolute neutrophil count < 1,000 cells / µL, platelet count < 50,000 cells / µL

 10. - Creatinine level > 170 µmol/L or requiring dialysis.

 11. - Bilirubin, transaminases or GamaGT > 3 UNL (upper normal limit)

 12. - Positive HIV serology, evidence of active Hepatitis B and C infection

 13. - Severe active infection

 14. - Inability to comply with an anti-thrombotic treatment regimen

 15. - A personal medical history of severe psychiatric disease

 16. - Uncontrolled diabetes contraindicating the use of high-dose dexamethasone

 17. - Non-controlled or severe cardiovascular disease (including a myocardial infarction
 in the 6 months prior to recruitment)

 18. - A personal medical history of cancer unless the patient has been without relapse
 after treatment discontinuation > or = 5 years (except for basocellular skin cancer or
 in situ cervical cancer)

 19. - Use of any investigational drug in the 30 days preceding randomization 22 - Pregnant
 or lactating women. 23 - Adults under juridical protection 24 - Known or suspected
 hypersensitivity to any of the study therapies or excipients 25 - Necessity of
 vaccination for yellow fever or with any other live vaccines