Febrile Urinary Tract Infection Randomized Short Treatment Trial
Febrile Urinary Tract Infection Randomized Short Treatment Trial
The purpose of this study is to determine whether a 7-day duration of antibiotic treatment of
 febrile urinary tract infection (FUTI) is non inferior to 14-day standard duration of
 treatment in unselected population presenting at primary care or emergency department.
In the last decades hospitalization rates of patients with acute pyelonephritis (AP) or FUTI
 has decreased from almost 100% to 10-30%. The outpatient management of patients with FUTI has
 become popular as well as oral antimicrobial treatment regiments and shortening of treatment
 duration. However, as such approaches are only discovered in otherwise young health
 non-pregnant women, the best management of FUTI in the elderly, men and patients with
 co-morbidity remains elusive. Bases on personal perception of the attending physician
 antibiotic treatment, duration varies approximately between 7-14 days. Facing the aging of
 the general population, it is urgent to better define the optimal treatment for AP or FUTI in
 an unselected population and to identify those at risk for treatment failure or poor outcome
 to guide and optimize individual patient management and to prevent on the one hand
 unnecessary long treatment duration and hospital admission and on the other hand unsafe short
 duration or unsafe outpatient management.

 In this study the efficacy and safety of a 7-day antimicrobial regimen compared to a 14-day
 antimicrobial regimen will be evaluated in an unselected population presenting with FUTI at
 primary care or emergency department. In addition a clinical and/or biomarker based scoring
 system of disease severity will be derived to predict those at risk for treatment failure or
 poor outcome.
Inclusion Criteria:

 -  Competent patient aged 18 years or above

 -  One or more symptom(s) suggestive of urinary tract infection (dysuria, frequency or
 urgency*; perineal or suprapubic pain; costo-vertebral tenderness or flank pain)

 -  Fever (ear or rectal temp of 38.2 oC or higher, or axillary temp of 38 oC or higher),
 or history of feeling feverish with shivering or rigors in the past 24 hours

 -  Positive urine nitrate test and/or leucocyturia as depicted by positive leukocyte
 esterase test or microscopy

 Exclusion Criteria:

 -  Known allergy to fluoroquinolones

 -  Female patients who are pregnant or lactating

 -  Patients with known polycystic kidney disease

 -  Patients on permanent renal replacement therapy (hemodialysis or peritoneal dialysis)

 -  Patients with history of kidney transplantation

 -  Residence outside country of enrolment

 -  Inability to speak or read Dutch

 -  Isolated causal uropathogen resistant to ciprofloxacin

 -  Renal abscess

 -  Chronic bacterial prostatitis

 -  Suspicion or evidence of any metastatic infectious foci