Clomiphene Citrate for Treatment of Acromegaly
Clomiphene Citrate for Treatment of Acromegaly
To assess the impact of clomiphene citrate on serum insulin like growth factor 1 and
 testosterone levels in male acromegalic patients not controlled by surgery, radiotherapy
 and/or medical treatments (somatostatin analogues, dopamine agonists and/or growth hormone
 receptor antagonist)
Acromegaly, a disease caused by a growth hormone secreting pituitary adenoma, results in
 reduced life span. Despite the many modalities available to treat this disease,as surgery,
 medical treatment and radiotherapy, uncontrolled disease persists in a significant portion of
 patients

 Oral estrogens, alone or in combination with somatostatin receptor analogues, have been shown
 to control acromegaly in women. Selective estrogen receptor modulators (SERMs) resulted in
 similar effects in both genders. Clomiphene citrate, a SERM that increases luteinizing
 hormone and follicle stimulating hormone secretion, improves hypogonadism and fertility
 outcomes.

 The aim of this study is to assess the impact of clomiphene citrate on serum insulin like
 growth factor 1 and testosterone levels in male acromegalic patients not controlled by
 surgery, radiotherapy and/or medical treatment.

 In this prospective, open label, single center trial, sixteen male patients were studied.
 Clomiphene citrate (50 mg/day) was added to previous medical treatment for 3 months and
 hormonal assessment was performed prior to and during the intervention. Hormones included:
 growth hormone, insulin like growth factor, total testosterone, follicle stimulating hormone,
 luteinizing hormone and prostate-specific antigen.
Inclusion Criteria:

 -  patients with active acromegaly on regular use of a stable dose of Octreotide-LAR
 and/or cabergoline for at least one year,

 -  Insulin like growth factor 1 above the reference range during the last year of
 follow-up and

 -  testosterone levels within or below the third inferior tertile of normality.

 Exclusion Criteria:

 -  radiotherapy in the last 10 years, previous venous embolism (including family
 members),

 -  previous prostatic cancer or symptomatic benign hypertrophy,

 -  triglyceride levels above 400 mg/dL,

 -  renal failure defined by estimative of renal filtration below 30 ml/min,

 -  liver disease defined by hepatic enzymes 3 times above normal limit,

 -  active oncologic disease in the last 10 years and previous cardiac or cerebrovascular
 disease.