MRI Compatible and Long-term LFP Recordable Deep Brain Stimulation on PD Patients
MRI Compatible and Long-term LFP Recordable Deep Brain Stimulation on PD Patients
Deep Brain Stimulation represents the golden standard for surgical treatment of Parkinson's
 disease (PD), but it is not optimally effective for controlling every motor sign and adverse
 events are not so infrequent. Therefore,other approaches should be considered. New Approaches
 in MRI at 3T and long-term local field potential (LFP) recording are very important to target
 subthalamic nucleus (STN) and understand mechanisms of DBS on Parkinson Patients. This study
 aims at evaluating the safety and effectiveness of 3T MRI Compatible and LFP recordable deep
 brain stimulation on PD patients. The Chronically LFP recording using G106R is for two goals:
 1) Evaluate the performance of long-term recordable neural simulation. 2) Study long-term
 clinical and electrophysiology effects of deep brain stimulation on STN.
Inclusion Criteria:

 1. Age ≥18，≤75，idiopathic Parkinson's disease，both male and female

 2. MMSE score ≥24

 3. H-Y score ≥2.0 on the medicine off situation

 4. UPDRS-III score≥30 on the medicine off situation

 5. The duration of this disease ≥5 years

 6. Ability to provide informed consent as determined by preoperative neuropsychological
 assessment

 7. History of appropriate response to dopaminergic medication, with at least a 30%
 improvement in motor UPDRS with L-DOPA by history or in-clinic testing, for the PD
 patients

 8. Excellent responsiveness to levodopa

 9. ≥6h in medicine off state

 Exclusion Criteria:

 1. Lack of ability to provide informed consent as determined by preoperative
 neuropsychological assessment

 2. Otherwise not eligible for DBS surgery, for example known inability to undergo
 anesthesia

 3. Hydrocephalus，brain atrophy，cerebral infarction ，cerebralvascular diseases

 4. Patients who are unable to follow verbal instructions

 5. Other severe pathological chronic condition that might confound treatment effects or
 interpretation of the data