Pharmacodynamics Of Product Octreotide Acetate Lar 30 Mg, Imported And Distributed By The Laboratory Chemical Pharmaceutical Bergamo Ltda., Compared To Product Sandostatin LAR ® (Octreotide Acetate LAR) 30 MG Manufactured By Novartis Biosciences S / A.
Pharmacodynamics Of Product Octreotide Acetate Lar 30 Mg, Imported And Distributed By The Laboratory Chemical Pharmaceutical Bergamo Ltda., Compared To Product Sandostatin LAR ® (Octreotide Acetate LAR) 30 MG Manufactured By Novartis Biosciences S / A.
Check the pharmacodynamics of the drug octreotide acetate LAR 30 mg imported and distributed
 by Chemical Laboratory Pharmaceutical Bergamo Ltda. compared to the drug Sandostatin LAR ®
 (octreotide acetate 30 mg) manufactured by Novartis Biociências S / A, using as activity
 analysis of growth hormone (GH) and growth factor insulin-like 1 (IGF-1 ) after a single dose
 of the drug in patients with acromegaly
Secondly, it will be observed safety (tolerability) in clinical patients by comparing the
 clinical and laboratory parameters before and after the study and the incidence of adverse
 events after a single dose
Inclusion Criteria:

 - Accept the Terms of Consent;

 -  be aged over 18, regardless of sex;

 -  Patients with acromegaly who presented GH levels ≥ 2.5 ng / mL or no suppression of GH
 levels to less than 1 ng / mL after tolerance test glucose and IGF-I levels for age
 and sex;

 -  Patients undergoing hypophysectomy followed by radiotherapy or not and to keep níves
 increased GH and IGF-I;

 -  Patients waiting hypophysectomy with increased levels of GH and IGF-I

 Exclusion Criteria:

 -  Have participated in any experimental study or have ingested any drug trial within six
 months prior to the start of the study;

 -  Have made use of medications that influence the results, regular 4 weeks prior to the
 start of the study or having used any medication a week before the start of the study;

 -  Have been treated with somastostatina analog or dopamine agonist in the last 2 months;

 -  Present history of myocardial infarction, angina and / or heart failure;

 -  Patients who present calculation of the gallbladder and have not undergone
 cholecystectomy;

 -  Pregnant women and nursing;

 -  Patients who have allergies to medicine;

 -  Patients with a history of acute pancreatitis;

 -  Patient with altered levels of amylase