Effects of Melatonin in PCOS Women
Effects of Melatonin in PCOS Women
The aim of our study is to investigate the effects of a treatment with melatonin on clinical,
 endocrine and metabolic features in women affected by PCOS. The study group included 40
 patients treatend with 2 mg of melatonin daily for six months. Menstrual pattern,
 anthropometric parameters, hirsutism score, ultrasound ovarian volume and antral follicular
 count, an oral glucose tollerance test and hormonal assays are evaluated before and after
 therapy.
Inclusion Criteria:

 -  women with PCOS in accordance with Rotterdam criteria

 Exclusion Criteria:

 -  pregnancy

 -  past history of cardiovascular diseases

 -  diabetes mellitus (or impaired glucose tolerance as determined by a standard 75 gr
 oral glucose tolerance test)

 -  hypertension

 -  significant liver or renal impairment

 -  other hormonal dysfunction (hypothalamic, pituitary, thiroidal or adrenal)

 -  neoplasms