Step-down of Inhaled Corticosteroids (ICS) in Non-eosinophilic Asthmatics
Step-down of Inhaled Corticosteroids (ICS) in Non-eosinophilic Asthmatics
There is growing evidence that non-eosinophilic asthmatics are less sensitive to inhaled
 corticosteroids (ICS) than eosinophilic asthmatics.

 As non-eosinophilic asthmatic patients are treated by ICS according to international
 guidelines for asthma, the investigators would like to investigate whether stepping-down of
 ICS in these patients may be safe. Indeed, the investigators can reasonably expect that a
 progressive cessation of ICS is possible in some of these patients without any clinical
 worsening.
For patients whose asthma is not controlled at the beginning of the study, a step-up of the
 treatment is planned to the step 4 of Global Initiative for Asthma (GINA). This step-up will
 last for 3 months and will permit to ensure that these patients achieve the best possible
 level of asthma control. A progressive step-down of the inhaled corticosteroids (ICS) will
 then be achieved.

 For patients whose asthma is controlled at the beginning of the study, a progressive
 step-down of the ICS will be directly achieved.

 The progressive step-down of the ICS dose will be undertaken every 3 months according to the
 dose levels defined by GINA guidelines (from high to low daily dose) until a complete
 cessation of the ICS for 6 months. Other associated asthma treatment of asthma will be kept
 unchanged.

 At each quarterly visit, a clinical composite outcome will be measured, for each patient.
 This composite outcome includes the score of asthma control questionnaire (ACQ) and the
 number of exacerbations. This outcome will determine at each visit if patients continue the
 study (success criterion) or stop the study (failure criterion). The success criterion is
 defined in the section "Current Primary Outcome"
Inclusion Criteria:

 -  At least 18 years of age

 -  Physician-diagnosed asthma based on the presence of typical symptoms (wheezing,
 breathlessness, chest tightness, cough)

 -  Asthma confirmed by:

 -  Forced expiratory volume in 1 second (FEV1) increase of at least 12% and 200 mL
 after inhalation of 400 mcg salbutamol

 -  And/or a provocative concentration of methacholine causing a 20% fall in FEV1
 (PC20M) less than 16 mg/ml

 -  Sputum eosinophils rate less than 3%

 -  Absolute blood eosinophils count less than 400 per mm3

 -  Treatment with a stable dose of inhaled corticosteroid (ICS) for the previous three
 months

 Exclusion Criteria:

 -  High risk of asthma-related death, defined by:

 -  Near-fatal asthma history, requiring a stay in an intensive care unit

 -  Current using or recent discontinuation (four weeks) of oral corticosteroids
 (OCS)

 -  Treatment with omalizumab

 -  Pregnant women