Effect of Treatment for Vitamin D Deficiency on Thyroid Function and Autoimmunity in Hashimoto's Thyroiditis.
Effect of Treatment for Vitamin D Deficiency on Thyroid Function and Autoimmunity in Hashimoto's Thyroiditis.
The objective of this study is to evaluate the effect of vitamin D supplementation on thyroid
 autoimmunity, thyroid function, and other metabolic and clinical variables associated with
 the thyroid axis in patients with Hashimoto's thyroiditis and vitamin D deficiency.
Inclusion Criteria:

 -  women between 18-45 years old (pre-menopausal stage)

 -  men between 18-60 years old

 -  BMI between 18.5-34.9 kg/ m2

 -  medical diagnosis of Hashimoto's thyroiditis

 -  treatment with levothyroxine (LT4) with stable dose (from four months from the start
 of the intervention)

 -  positive antithyroid antibody (peroxidase and/or thyroglobulin)

 -  serum 25 (OH) D levels <20 ng / ml.

 Exclusion Criteria:

 -  radioiodine, thyroidectomy, antithyroid treatment

 -  disease, condition or drug treatment that alters the immune system or
 hypothalamic-pituitary-thyroid axis or vitamin D metabolism.

 -  disorder of kidney, liver, or bone-metabolic function

 -  Graves disease, toxic nodular goiter, postpartum thyroiditis, coronary heart disease,
 epilepsy, cancer, Turner or Down syndrome, primary hyperparathyroidism

 -  vitamin D, calcium, complex B, omega-3 supplements

 -  pregnant or breastfeeding

 -  type 2 diabetes or dyslipidemia with drug treatment at unstable doses

 -  intense physical activity