Two Different Surgical Methods of Blepharospasm
Two Different Surgical Methods of Blepharospasm
1. Background: Blepharospasm refers to orbital and periorbital orbicularis muscle
 spontaneous spasmodic contraction. Continuous spasm can be long or short, the
 performance of non spasm will strongly closed repeatedly. At present, the pathogenesis
 of blepharospasm is not clear, in addition, there is no particularly effective
 treatment.

 2. Purpose：compare two different surgical methods, observe the improvement of symptoms and
 prognosis of patients with blepharospasm.

 3. Scientific hypothesis: At present, the pathogenesis of blepharospasm is not clear, but
 clinical patients with blepharospasm showed bilateral eyelid twitching, eyes open
 difficulties and the symptoms are worse when tension, anxiety, insomnia, light
 stimulation and wind outside stimulation. At the same time, in the clinic，the
 investigators found that facial nerve and trigeminal nerve combing can improve the
 clinical symptoms of the patients. Therefore, the investigators speculated that over
 activity were related to clinical symptoms and corneal reflex pathway of blepharospasm
 patients.

 4. Research content: the blepharospasm patients were randomly divided into two groups,
 prospective comparative analysis of two different surgical methods for the treatment of
 blepharospasm. One group of patients were performed facial nerve combing and
 microvascular decompression, the other group of patients were performed facial nerve,
 trigeminal nerve combing with microvascular decompression, to observation of
 postoperative clinical improvement of two groups of patients.

 5. Expected results:To define a surgical method for the treatment of blepharospasm, and to
 promote the use of the academic and clinical practice.
Background: Blepharospasm refers to orbital and periorbital orbicularis muscle spontaneous
 spasmodic contraction. Continuous spasm can be long or short, the performance of non spasm
 will strongly closed repeatedly. At present, the pathogenesis of blepharospasm is not clear,
 in addition, there is no particularly effective treatment.

 Purpose：compare two different surgical methods, observe the improvement of symptoms and
 prognosis of patients with blepharospasm.

 Scientific hypothesis: At present, the pathogenesis of blepharospasm is not clear, but
 clinical patients with blepharospasm showed bilateral eyelid twitching, eyes open
 difficulties and the symptoms are worse when tension, anxiety, insomnia, light stimulation
 and wind outside stimulation. At the same time, in the clinic，the investigators found that
 facial nerve and trigeminal nerve combing can improve the clinical symptoms of the patients.
 Therefore, the investigators speculated that over activity were related to clinical symptoms
 and corneal reflex pathway of blepharospasm patients.

 Research content: the blepharospasm patients were randomly divided into two groups,
 prospective comparative analysis of two different surgical methods for the treatment of
 blepharospasm. One group of patients were performed facial nerve combing and microvascular
 decompression, the other group of patients were performed facial nerve, trigeminal nerve
 combing with microvascular decompression, to observation of postoperative clinical
 improvement of two groups of patients.

 Expected results:To define a surgical method for the treatment of blepharospasm, and to
 promote the use of the academic and clinical practice.
Inclusion Criteria:

 1. Patients with bilateral blepharospasm

 2. Clinical symptoms more than 1 years.

 3. Patients who are willing to undergo surgery.

 4. Preoperative patients who had not been treated with botulinum toxin.

 Exclusion Criteria:

 1. Patients with serious heart and lung dysfunction can not tolerate surgery.

 2. The clinical symptoms of the patients less than 1 years.

 3. Patients who received local botulinum toxin treatment for a long time.

 4. Patients with severe mental disorders.