The Role of Gut Leakage Markers and Microbiota Signature in Coronary Artery Disease.
The Role of Gut Leakage Markers and Microbiota Signature in Coronary Artery Disease.
Define a signature of gut microbiota composition and related metabolites in patients with
 ST-elevation myocardial infarction, non ST-elevation myocardial infarction and chronic
 coronary disease (CAD).
A total of 200 patients, allocated to 50 patients with chronic coronary syndrome, 75 patients
 with non-ST elevation myocardial infarction and 75 patients with ST- elevation myocardial
 infarction will be included. Clinical information, blood samples and fecal samples will be
 collected. Fecal and blood samples will be collected once in patients With chronic disease
 and in patients with acute coronary syndrome; in the acute phase and after 3 months.
Inclusion Criteria:

 -  Coronary heart disease verified by coronary angiography

 Exclusion Criteria:

 -  Current infection requiring intravenous antibiotics

 -  Inflammatory bowel disease

 -  Renal failure with creatinine > 200µmol/L

 -  Hepatic impairment

 -  Pregnancy

 -  Previous bariatric surgery

 -  Colostomy

 -  Active malignant disease