Bisphenol Role in the Pathogenesis of PCOS
Bisphenol Role in the Pathogenesis of PCOS
Polycystic ovary syndrome (PCOS) is the most common and the most heterogeneous endocrine
 disorder in premenopausal women. Its prevalence is estimated from 5 to 10% depending on the
 diagnosis' criteria .

 Apart from signs of hyperandrogenism such as acne, hirsutism and hair loss; women with PCOS
 usually present with menstrual irregularities and fertility problems ..
Bisphenol A is formed from acetone and phenol, it is used in production of epoxy resin,
 polyster resins and polyvarbonate resins. Epoxy resins are used in plastics, adhesives, and
 structural composites .

 Humans are at the end of the food chain, thus they are exposed to the highest doses of these
 compounds. EDs have been detected in human adipose tissue and biological fluids such as:
 serum, urine, milk and amniotic fluid .

 Additionally, it has been proven that BPA can also directly stimulate androgen synthesis in
 the ovarian theca-interstitial cells. A correlation between increased serum testosterone
 levels observed in women with PCOS with serum BPA concentrations has also been found .
Inclusion Criteria:

 -  Age group: 18-40

 -  Females

 -  Diagnosed a case of polycystic ovary syndrome

 Exclusion Criteria:

 -  • Female patients with other acute or chronic illness

 -  Cardiovascular disease

 -  Neoplasms

 -  Current smoking, diabetes mellitus,

 -  Renal impairment (serum creatinine 120 mol/liter), and hypertension (blood
 pressure 140/85 mm Hg).