Point of Care Susceptibility Testing in Primary Care
Point of Care Susceptibility Testing in Primary Care
The purpose of this study is to determine whether point-of-care susceptibility testing
 improve correct choice of antibiotics, clinical and microbiological outcome in patients with
 uncomplicated urinary tract infection in general practice compared to point-of-care urine
 culture.
700-900 patients with symptoms of uncomplicated urinary tract infection, consecutively
 contacting their GP, randomized to either point of care test (POCT) urine culture and
 empirical treatment or POCT urine culture and susceptibility testing and targeted treatment.
 Patients are included until 440 with verified positive cultures are included. The two groups
 are compared with regard to correct choice of antibiotics, clinical remission and
 microbiological cure rates.
Inclusion Criteria:

 -  Female adult patients

 -  18 years or older

 -  Presenting at their GP with dysuria

 -  Frequency or urgency, which have been present for 7 days or less and where the GP
 suspects uncomplicated UTI.

 -  Patients should be able to deliver a mid-stream urine sample, to provide informed
 consent and be willing and able to fill out a symptom diary.

 Exclusion Criteria:

 -  Negative dipstick analysis

 -  Complicated urinary tract infection

 -  Known pregnancy

 -  Severe systemic symptoms, high fever, flank pain

 -  Recent bladder surgery (within past 4 weeks)

 -  Urinary tract abnormalities

 -  Serious systemic disease

 -  Life-threatening cancer

 -  Insulin dependent diabetes

 -  Long-term corticosteroid treatment

 -  Other conditions with compromised immunity

 -  Former participation in the study

 -  Patients presenting on a Friday (since the POCT must be read after 24 hours)