Surgical Outcome and Differences on Histopathology in Patients With Alcoholic & Non Alcoholic Chronic Pancreatitis
Surgical Outcome and Differences on Histopathology in Patients With Alcoholic & Non Alcoholic Chronic Pancreatitis
Numerous treatment modalities have been proposed to treat pain in alcoholic and non-alcoholic
 chronic pancreatitis such as analgesic medication, inhibition of gastric acid production,
 enzyme substitution, somatostatin analogues, nerve blockade,reduction of oxidative stress and
 endoscopic pancreatic duct stenting, but none of these concepts have shown long lasting
 benefits as surgery in clinical studies.Comparison of surgical outcome in non-alcoholic
 chronic pancreatitis and alcoholic chronic pancreatitis has limited data and differences on
 the basis of outcome in between alcoholic and non-alcoholic chronic pancreatitis are not
 available in literature.

 Although it is well known that pain is the main symptom of chronic pancreatitis, it has until
 now been assessed in very common and varying categories. Pain, however, is only one aspect of
 the large variety of sensitive facets of daily life. In addition to an improvement in pain
 symptoms and the preservation of pancreatic exocrine and endocrine function and other
 parameters, occupational rehabilitation of these mostly young patients and quality of life
 also should be considered in the evaluation of surgical outcome in alcoholic and
 non-alcoholic chronic pancreatitis.

 In this prospective study, we intend to find out if there are any differences in the surgical
 outcome on the above mentioned parameters in alcoholic and non-alcoholic chronic
 pancreatitis.We also plan to see if there are differences in the histopathology in these two
 disease settings.
Inclusion Criteria:

 Diagnosis of chronic pancreatitis confirmed by at least 2 of the following:

 1. Typical Chronic epigastric abdominal pain

 2. Elevation of serum Amylase>3 times upper limit normal or

 3. Fecal elastase less than 200ug/g stool.

 4. Confirmatory findings on cross-sectional imaging:

 1. Changes in size, shape and contour of pancreas

 2. Dilatation of main pancreatic duct

 3. Calcification

 4. Pseudocyst

 5. Pancreatic duct stricture

 5. Patients who fulfill the criteria for surgical intervention

 Exclusion Criteria:

 -  Not agreeing for surgical management

 -  On going acute pancreatitis

 -  Postop alcohol intake

 -  Pregnancy.

 -  Chronic pancreatitis with Malignancy