Non-invasive Ventilation Versus Continuous Positive Airway Pressure in Cardiogenic Pulmonary Edema
Non-invasive Ventilation Versus Continuous Positive Airway Pressure in Cardiogenic Pulmonary Edema
The aim of the present study was to demonstrate that an Non-Invasive Ventilation (NIV)
 performs better than a Continuous Positive Airway Pressure (CPAP) in the management of
 Cardiogenic Pulmonary Edema (CPE) within an Intensive Care Unit (ICU) setting.
Continuous Positive Airway Pressure (CPAP) and Non-Invasive Ventilation (NIV), has played a
 decisive role in the treatment of Acute Respiratory Failure (ARF) secondary to Cardiogenic
 Pulmonary Edema (CPE). The use of either CPAP or NIV has resulted in greater clinical
 improvements than the ones that have been previously obtained by using a standard medical
 therapy. Although there is a strong indication for NIV in hypercapnic patients, the situation
 whether NIV is superior to CPAP remains unclear, and hence, both have been recommended.

 NIV and CPAP have both been successfully used in patients admitted to an Intensive Care Unit
 (ICU) suffering from CPE. However, few trials have been published on the ICU scenario. In
 addition, Acute Coronary Syndrome (ACS) has been considered to be an exclusion criterion in
 several trials.

 At the time of the onset of CPE, either in the Emergency Department (ED) or in the ward, all
 participants received a standard medical therapy (oxygen through a Venturi mask, morphine,
 intravenous nitroglycerin if their systolic blood pressure >160 mmHg, together with loop
 diuretics), all at the discretion of the attending physician. In the absence of a clinical
 improvement [dyspnea, respiratory rate >25rpm, transcutaneous arterial oxygen saturation
 (SaO2) <90%], the participant was admitted to the ICU and assigned to the NIV group or the
 CPAP group, regardless of the treatment that they had received in the ED. The participants
 that were admitted to the ICU at the onset of CPE were randomised without a trial of medical
 treatment. The assignment of each group was performed by opening a sealed envelope following
 a prior randomisation by using a computerised system.

 Statistical. A comparative analysis was conducted by using the Student's t-test or the
 Mann-Whitney test for a comparison of the quantitative variables for the parametric and
 non-parametric characteristics, respectively. For the qualitative variables, the
 investigators used the Chi-Square statistic or Fisher's exact test. A statistical
 significance was reached if P<0.05. The cumulative probability of survival was compared by
 using a Kaplan-Meier estimation of survival and a Log-Rank Test to compare both of the
 groups.
Inclusion Criteria:

 -  Participants suffering from CPE, defined as having the presence of dyspnea,
 respiratory rate >25 breaths/minute, the use of accessory respiratory muscles,
 cyanosis, cold sweats, bilateral crackles and/or wheezing on pulmonary auscultation,
 hypoxaemia, hypertension, and a predominance of bilateral pulmonary infiltrates upon a
 chest radiography (if available).

 -  The potential causes of CPE have been understood to be Acute Coronary Syndrome (ACS)
 with or without a persistent ST-segment elevation, hypertensive emergency,
 valvulopathy, acute arrhythmia, endocarditis, or decompensation due to a chronic heart
 failure.

 Exclusion Criteria:

 -  The exclusion criteria were: a refused consent, the patient's inability to cooperate,
 severe encephalopathy (Glasgow Coma Score <10)

 -  Anatomical difficulty when adjusting the face mask, non-cardiogenic Acute Respiratory
 Failure (pneumonia, blunt chest trauma, or chronic obstructive pulmonary disease)

 -  Respiratory or cardiac arrest on admission, together with the need for an immediate
 intubation.

 -  Specific cardiac contraindications were also considered, including: cardiogenic shock
 on admission established by systolic blood pressure (SBP) <90 mmHg, or a dependence on
 vasoactive drugs (norepinephrine >0.5 µg/kg/min).