China Angioplasty & Stenting for Symptomatic Intracranial Severe Stenosis
China Angioplasty & Stenting for Symptomatic Intracranial Severe Stenosis
Patients with symptomatic stenosis of intradural arteries are at high risk for subsequent
 stroke. Since the SAMMPRIS trial, stenting is no longer recommended as primary treatment,
 however, the results of this trial, its inclusion criteria and its center selection received
 significant criticism and did not appear to reflect our experience, neither regarding natural
 history, nor treatment complications rate. As ICAS is the most common cause for stroke in
 Asian countries, we are hereby proposing a refined prospective randomized multicenter study
 in an Asian population with strictly defined patient and participating center inclusion
 criteria.

 The China Angioplasty & Stenting for Symptomatic Intracranial Severe Stenosis (CASSISS)
 trial, is an ongoing, government-funded, prospective, multicenter randomized trial. It
 recruits patients with recent TIA or stroke caused by 70-99% stenosis of a major intracranial
 artery. Patients with previous stroke related to perforator ischemia will not be included.
 Only high-volume center with a proven track record will enroll patients as determined by a
 lead-in phase. Patients will be randomized (1:1) to best medical therapy alone or medical
 therapy plus stenting. Primary endpoints are any stroke or death within 30 days after
 enrollment or after any revascularization procedure of the qualifying lesion during
 follow-up, or stroke in the territory of the symptomatic intracranial artery beyond 30 days
 The CASSISS trial will be conducted in 8 sites in China with core imaging lab review at a
 North American site and aims to have a sample size of 380 subjects (stenting, 190; medical
 therapy, 190). Recruitment is expected to be finished by Dec, 2016. Patients will be followed
 for at least three years. The trial is scheduled to complete in 2019. In the proposed trial,
 certain shortcomings of SAMMPRIS including patient and participating center selection will be
 addressed. The present manuscript outlines the rationale and design of the study. We estimate
 that this trial will allow for a critical reappraisal of the role of intracranial stenting
 for selected patients in high volume centers.
Although SAMMPRIS trial has had an impact on the current treatment of intracranial
 atherosclerotic (ICAS), criticism regarding to its design were still raised and remained
 unsettled. In light of SAMMPRIS, medical therapy could not be good as it was; neither
 stenting for ICAD need to be abolished, but rather its role needs to be redefined by future
 prospective trials. Moreover, China is a developing country, and has the world's largest
 population. Since 2010, stroke has been the leading cause of death in China and confers a
 huge burden and effort on patients and health professionals. Compared with western countries,
 ICAS is the most common vascular lesion in patients with cerebro-vascular disease, and is an
 important cause of ischemic stroke and future recurrent events in China. However, its
 treatment strategy and long-term result has not been well determined. The health burden in
 China and ethnic difference of ICAS incidence as well as the willingness to continue clinical
 trials, support the need for ongoing CASSISS in China.

 Pre-CASSISS registry trial:

 A registration pilot trial was performed prior to CASSISS. It aimed to test the credentialing
 of interventionists and participating centers. From July 2013 to Mar 2014, 12 candidates were
 involved in a competitive registration study of recruiting 100 consecutive patients. The
 patients received stenting using Wingspan at each site. As for the candidate centers, the
 following aspects will be considered: stenting experiences, peri-operative complications, and
 the volume of stenting cases. Those met the following criteria were not involved into the
 subsequent randomization trial: 1) each center performed more than 5 procedures; 2) clinical
 results demonstrated the complication rates were more than 15% (stroke or death). At last, 4
 sites were excluded and the remaining 8 were certified and invited for the final
 randomization trial.
Inclusion criteria：

 1. eligible patients aged between 30-80 years; intracranial arterial stenosis related to
 the following non-atherosclerotic factors will be not be considered: arterial
 dissection, moya-moya disease; vasculitic disease; herpes zoster, varicella zoster or
 other viral vasculopathy; neurosyphilis; any other intracranial infection; any
 intracranial stenosis associated with cerebrospinal fluid pleocytosis;
 radiation-induced vasculopathy; fibromuscular dysplasia; sickle cell disease;
 neurofibromatosis; benign angiopathy of central nervous system; postpartum angiopathy;
 suspected vasospastic process, and suspected recanalized embolus;

 2. Symptomatic ICAS: presented with TIA or stroke within the past 12 months attributed to
 70%-99% stenosis of a major intracranial artery (internal carotid artery, MCA [M1],
 vertebral artery, or basilar artery);

 3. Degree of stenosis: 70%-99%; stenosis degree must be confirmed by catheter angiography
 for enrollment in the trial;

 4. There might be remote infarctions on MRI scan, which could be accounted by the
 occlusion of the terminal cortical branches or hemodynamic compromise (perforator
 occlusion excluded). Infarction due to perforators occlusion is defined as basal
 ganglia or brainstem/thalamus infarction related with MCA or BA stenosis;

 5. Expected ability to deliver the stent to the lesion;

 6. All the patients should be performed with stenting beyond a duration of 3 weeks from
 the latest ischemic symptom onset;

 7. No recent infarctions identified on MRI (indicated as high signals on DWI series) upon
 enrollment;

 8. No massive cerebral infarction (>1/2 MCA territory), intracranial hemorrhage, epidural
 or sub-dural hemorrhage, and intracranial brain tumor on CT or MRI scan;

 9. mRS scale score of <=2;

 10. Target vessel reference diameter must be measured to be 2.00 mm to 4.50 mm; target
 area of stenosis is <=14 mm in length;

 11. No childbearing potential or has a negative pregnancy test within the past 1 week
 prior to study procedure; female patients had normal menses in the last 18 months;

 12. Patient is willing and able to return for all follow-up visits required by the
 protocol;

 13. Patients understand the purpose and requirements of the study and have signed informed
 consent form.

 Exclusion criteria:

 1. Refractory to general anesthesia; patients were not able to be overcome by
 pre-treatment with medical therapy.

 2. Any condition that precludes proper angiographic assessment.

 3. Tandem extracranial or intracranial stenosis (70%-99%) or occlusion that is proximal
 or distal to the target intracranial lesion.

 4. Bilateral intracranial VA stenosis of 70%-99% and uncertainty about which lesion is
 symptomatic (e.g., if patient has pon, midbrain, temporal and occipital symptoms).

 5. Presence of a previously placed intravascular stent or graft in the ipsilateral
 distribution within 30 days.

 6. Previous treatment of target lesion with a stent, angioplasty, or other mechanical
 device, or plan to perform staged angioplasty followed by stenting of target lesion.

 7. Severe vascular tortuosity or anatomy that would preclude the safe introduction of a
 guiding catheter, guiding sheath or stent placement.

 8. Plan to perform concomitant angioplasty or stenting of an extracranial. vessel tandem
 to an ipsilateral intracranial stenosis.

 9. Presence of intraluminal thrombus proximal to or at the target lesion.

 10. Any aneurysm proximal to or distal to intracranial stenotic artery.

 11. Intracranial tumors or any intracranial vascular malformations.

 12. Computed tomographic or angiographic evidence of severe calcification at target
 lesion.

 13. Thrombolytic therapy within 24 hours before enrollment.

 14. Evolving stroke or progressive neurologic signs within 24 hours before enrollment.

 15. Stroke of sufficient size (>5cm on CT or MRI) to place patient at risk of hemorrhagic
 transformation during the procedure; hemorrhagic transformation of an ischemic stroke
 within the past 15 days.

 16. Previous spontaneous intracerebral (parenchymal) or other intracranial (subarachnoid,
 subdural, or epidural) hemorrhage within 30 days.

 17. Untreated chronic subdural hematoma >5 mm in thickness.

 18. Other cardiac sources of emboli such as left ventricular aneurysms, intracardiac
 filling defect, cardiomyopathy, aortic or mitral prosthetic heart valve, calcified
 aortic stenosis, endocarditis, mitral stenosis, atrial septal defect, atrial septal
 aneurysm, left atrial myxoma.

 19. Myocardial infarction within previous 30 days.

 20. Chronic atrial fibrillation; any episode of paroxysmal atrial fibrillation within the
 past 6 months, or history of paroxysmal atrial fibrillation requiring chronic
 anticoagulation.

 21. Intolerance or allergic reaction to any of the medical therapy, including aspirin,
 clopidogrel, heparin, and local or general anesthetics.

 22. History of life-threatening allergy to contrast medium. If not life-threatening and
 can be effectively pre-treated, patient can be enrolled at physicians' discretion.

 23. Recent gastro-intestinal bleed that would interfere with anti-platelet therapy.

 24. Active bleeding diathesis or coagulopathy; active peptic ulcer disease, major systemic
 hemorrhage within 30 days, active bleeding diathesis, platelets count <125,000,
 hematocrit <30, Hgb <10 g/dl, uncorrected INR >1.5, bleeding time >1 minute beyond
 upper limit normal, or heparin-associated thrombocytopenia that increases the risk of
 bleeding, uncontrolled severe hypertension (systolic BP>180 mm hg or diastolic BP>115
 mm hg), severe liver impairment (AST or ALT >3 times normal, cirrhosis), creatinine
 >265.2μmol/l (unless on dialysis)

 25. Major surgery (including open femoral, aortic, or carotid surgery) within previous 30
 days or planned in the next 90 days after enrollment.

 26. Indication for warfarin or heparin beyond enrollment (note: exceptions allowed for use
 of systemic heparin during stenting procedure or subcutaneous heparin for deep venous
 thrombosis prophylaxis while hospitalized).

 27. Inability to understand and cooperate with study procedures or sign informed consent

 28. Severe dementia or psychiatric problems that prevent the patients from following an
 outpatient program reliably.

 29. Pregnancy or of childbearing potential and unwilling to use contraception for the
 duration of this study

 30. Actively participating in another drug or device trial that has not completed the
 required protocol follow-up period.