Finding Correlations Between Asthma Exacerbation, Physiological Measurements and Environmental Factors
Finding Correlations Between Asthma Exacerbation, Physiological Measurements and Environmental Factors
To identify asthma-related physiological changes observed by wearable devices in real-world
 conditions by monitor multiple sensing modalities (e.g., heart rate (HR), heart rate
 variability (HRV), activity level, spirometry, coughing sounds) in order to find reliable
 signatures of impending asthma exacerbation and systematically explore any challenges on the
 use of wearable technologies.
The study aims to identify asthma-related physiological changes observed by wearable devices
 in real-world conditions. The investigators aim to monitor multiple sensing modalities (e.g.,
 heart rate (HR), heart rate variability (HRV), activity level, spirometry, coughing sounds)
 in order to find reliable signatures of impending asthma exacerbation and systematically
 explore any challenges on the use of wearable technologies. A variety of off-the-shelf
 devices as well as the prototype HET platform developed by the NCSU ASSIST center will be
 used for data collection.

 The investigators plan to engage adolescents (ages 14-18) for a period of up to four months
 of monitoring. They will be asked to wear the wrist monitoring device for at least 8 hours
 daily and chest monitoring devices for at least 12 hours a week, to take daily measurements
 using a spirometer, and answer weekly questionnaires online and virtual interviews (at
 1-week,1-month and 3-months) about their asthma control and experiences with the devices.

 Wearable devices are increasingly popular with young people and are capable of providing
 dynamically calculated up-to-the-minute measurements of a number of physiologic parameters,
 including heart rate, heart rate variability, respiratory rate, activity levels, and cough.
 The cough sounds the investigators hope to capture during a forced-cough recording and while
 sleeping can be used as biomarkers for early detection of exacerbation. These changes could
 be used to predict an asthma exacerbation, and provide the wearer with instant feedback
 allowing the user to intervene early and prevent progression to more severe symptoms. Young
 adults are likely to adopt wearable technologies to facilitate chronic disease management,
 making this an ideal age group to examine the utility of wearable devices to detect early
 physiologic predictors of an impending exacerbation.
Inclusion Criteria:

 -  Adolescents (14-18 years old) with asthma will be included.

 -  Participants will have to be diagnosed with persistent asthma (as characterized in
 their UNC health record) that is poorly controlled since this is the focus of the
 study. They will be identified as eligible for inclusion by the UNC Coordinator
 partner. However, they should not have any other lung disease other than asthma. They
 should not be taking any oral steroids every day to control their asthma. They should
 not need to use their asthma rescue medication multiple times a day to help with their
 asthma symptoms. They should not have experienced wheezing brought on when performing
 a lung function test.

 -  Participants should have Wireless Internet access at their homes

 -  Individuals with COVID-19 symptoms will be automatically excluded due to their
 clinical screening prior to their clinic visit. However, if a participant contracts
 COVID-19 during the study, they will be encouraged to continue participating since all
 interactions will be remote after the first clinical screening.

 -  Adolescents should be able to use a iOS device (provided by the researchers) and the
 devices (with assistance from parents when appropriate) for data collection efforts.
 They cannot participate in this study if they don't feel comfortable with operating
 the multiple devices including the iOS device. The iOS device can only be used for the
 purposes of this study. The iOS device will be restricted by enabling Parental Control
 Settings accessible only to the researchers.

 -  The participation of an adolescent may be terminated by the investigator if they do
 not follow the guidelines for the study, including using the devices as instructed or
 participating in the interviews and weekly surveys. Also, the monthly renewal for the
 participation of the study (up to 4 months) will be decided by the investigators on a
 month-by-month basis given that the participant also agrees to continue in the study.

 -  Individuals with physical challenges are allowed to be incidentally included as long
 as they satisfy all the previous criteria.

 Exclusion Criteria:

 -  none listed