Study to Evaluate the Efficacy of 2LEBV® and 2LXFS® on Asthenia in Patients With an Epstein-Barr Virus Infection
Study to Evaluate the Efficacy of 2LEBV® and 2LXFS® on Asthenia in Patients With an Epstein-Barr Virus Infection
Worldwide, 95% of adults are infected with Epstein-Barr Virus (EBV). These infections may
 cause different diseases. In most cases, EBV infection is asymptomatic because of a highly
 effective host immune response. Some individuals develop infectious mononucleosis (a
 self-limiting lymphoproliferative disorder in adolescents and young adults that is considered
 to be the primary infection), while others develop chronic fatigue syndrome, EBV-associated
 lymphoid, or epithelial malignancies.

 Today, there is no available treatment to treat and destroy EBV. The treatment is essentially
 symptomatic (treatment of the symptoms and not of the virus itself) with analgesics for pain
 for example.

 The studied drugs are 2LEBV® and 2LXFS®, from Labo'Life company, and the treatment schema is
 the same for the two drugs: it consists in taking the content of one capsule per day,
 sequentially, according to capsules' numerical order: 1 through 10. When capsule number 10 is
 taken, capsule 1 of the next blister should be taken on the next day to continue the
 treatment.

 The duration of treatment will be of 6 months of continuous intake of the content of 1
 capsule/day.

 The aim of this study is to provide additional information on effectiveness on the 2LEBV® and
 2LXFS®in the treatment of EBV chronic and acute infections, and in particular to demonstrate
 their effectiveness versus placebo in the reduction of asthenia and other symptoms in EBV
 infection.
Pré-Inclusion Criteria:

 -  Patients, male or female, aged 12 years and older,

 -  Patient with fatigue for 1 month or more,

 -  Patient with at least two other symptoms among the following: Long-lasting exhaustion
 even after light exertion, subfebrile state, fever, loss of appetite, nausea, angina,
 conjunctivis, sensitive cervical or axillary lymph nodes, erythematous and swollen
 tonsil, headaches, sore throat, myalgia, muscular weakness, arthralgia, splenomegaly,
 visual disorders, memory disorders, attention deficit disorders, sleep disorders,
 gastrointestinal disorders, breathing disorders, cardiovascular disorders.

 -  Patient (and/or parents if necessary) agrees to perform serology for the study,

 -  Patient (and/or parents if necessary) agrees to perform lymphocyte typing for the
 study during the pre-inclusion visit,

 -  Patients (and/or parents if necessary) having the faculties to understand and respect
 the constraints of the study,

 -  Signature of the Informed Consent Form by the patient (and/or parents if necessary).

 Inclusion Criteria:

 - Patient who have a positive serology for EBV (IgG and/or IgM positive).

 Exclusion Criteria:

 -  Patient who have received any treatment with the 2LEBV® or 2LXFS®,

 -  Patients who have received any homeopathic treatment in the previous 2 months prior to
 the study,

 -  Patients under immunosuppressive treatment,

 -  Patient undergoing treatment for psychiatric disorders,

 -  Patients having received immunotherapy or micro-immunotherapy during the last 3
 months,

 -  Patients with known lactose intolerance,

 -  Pregnant or breastfeeding women,

 -  Patients who participated in a clinical study in the previous 2-months period,

 -  Patients (and/or parents of patients if necessary) who are not sufficiently motivated
 to engage on the total study follow-up period, or likely to travel or to move before
 the end of the study,

 -  Patients with severe immunodeficiency disease requiring long term treatment (*) or
 patients under chemotherapy or radiotherapy,

 -  Patients under homeopathic or phytotherapy treatment,

 -  Patients addicted to or using recreational drugs,

 -  Patient under guardianship and/or curatorship, (*) important renal or respiratory
 insufficiency, transplanted or grafted patients, HIV/AIDS, terminal cancer.