The Effects of Dragon Fruit Consumption on Vascular Function.
The Effects of Dragon Fruit Consumption on Vascular Function.
Native to South America and South East Asia, the dragon fruit (pitaya) has become
 increasingly popular world-wide due to their vivid hue and bizarre structure. More
 importantly, their high levels of bioactive phytochemical betalains has sparked considerable
 scientific interest. Recent findings from in vitro and in vivo animal studies tentatively
 suggest that betalains may have ameliorative effects on vascular function. This will be a
 first randomised controlled trial aimed to explore the impact of dragon fruit consumption on
 blood pressure and other vascular parameters in healthy individuals. The study will feature a
 randomised, double-blinded, placebo-controlled and crossover design with flow-mediated
 dilatation (FMD) as primary outcome along with blood pressure and arterial stiffness as
 secondary outcomes. Cardiovascular biomarkers as well as relevant metabolites will also be
 determined from blood and urine samples collected from participants.
Inclusion Criteria:

 1. Healthy men and women aged 18-40 years old

 2. Subjects are willing to maintain their normal eating/drinking habits and exercise
 habits to avoid changes in body.

 weight over the duration of the study.

 3. Are able to understand the nature of the study.

 4. Able to give signed written informed consent.

 5. Signed informed consent form.

 Exclusion Criteria:

 1. Medical history of cardiovascular disease including coronary artery disease,
 cerebrovascular disease and peripheral artery disease.

 2. Hypertensive, as defined as SBP superior or equal to 140 mmHg.

 3. Obese participants, defined as BMI superior or equal to 30.

 4. Medical history of diabetes mellitus, metabolic syndrome, terminal renal failure or
 malignancies.

 5. Abnormal heart rhythm (lower or higher than 60-100 bpm).

 6. Allergies to berries or other significant food allergy.

 7. Subjects under medication that can affect the cardiovascular system or on
 vitamin/dietary supplements.

 8. Subjects who have lost more than 10% of their weight in the past 6 months or are
 currently in a diet

 9. Subjects who reported participant in another study within one month before the study
 start.

 10. Subjects who smoke an irregular amount of cigarettes per day.

 11. pregnant women or planning to become pregnant in the next 6 months.

 12. Any reason or condition that in the judgment of the clinical investigator(s) may put
 the subject at unacceptable risk or that may preclude the subject from understanding
 or complying with the study's requirements.