Brain MRI Imaging in Patients With SARS-Cov2 (COVID-19) Infection With or Without Anosmia
Brain MRI Imaging in Patients With SARS-Cov2 (COVID-19) Infection With or Without Anosmia
To date there is no brain imaging and olfactory data available in COVID-19 positive patients
 with anosmia. By describing the pathophysiological characteristics underlying the olfactory
 symptoms and clinical characteristics of COVID-19 infection, the study investigators wish to
 compare the MRI aspects obtained in COVID-19 patients with and without anosmia, in the
 absence of other underlying neurological disorders.
Brain mapping of COVID-19 patients with or without anosmia will allow better understanding of
 the mechanisms leading to the onset of these symptoms and will provide a pathophysiological
 basis for the therapeutic interventions to improve the clinical prognosis of affected
 patients.

 The study investigators hypothesize that in COVID-19 patients witch anosmia the brain mapping
 objectified by an MRI examination is modified and that there are functional abnormalities in
 the brain in these patients.
Inclusion Criteria:

 -  Consecutive adult patients consulting the CAREB or hospitalized at the Nîmes teaching
 hospital due to COVID-19 infection (fever, persistent cough, tiredness, shortness of
 breath, diarrhea, abdominal pain, chest pain, sore throat, loss of smell or taste)

 -  COVID-19 confirmed by RT-PCR and / or chest CT or clinical characteristics (i.e an
 epidemic history and 2 clinical manifestations or at least 3 clinical manifestations)

 -  The patient must have given their free and informed consent and signed the consent
 form

 -  The patient must be a member or beneficiary of a health insurance plan "with anosmia"
 group:

 -  scoring < 30 on a VAS 0-100 for olfactory ability

 -  Responding "yes" to question "have you lost your sense of smell in the last few days?"

 -  Negative result to olfactory test with n-Butanol diluted to 1/1000. "without anosmia"
 group:

 -  scoring < 80 on a VAS 0-100 for olfactory ability

 -  Responding "no" to question "have you lost your sense of smell in the last few days?"

 -  Positive result to olfactory test with n-Butanol diluted to 1/16000.

 Exclusion Criteria:

 -  Patient suffering from serious medical problems or hospitalized in an intensive care
 unit for invasive ventilation or severe dyspnea.

 -  Patient with neurological (motor, sensitive or cognitive), neuropsychiatric or
 vascular disorders.

 -  Patient with a contraindication to MRI (pace maker, claustrophobic patient, metallic
 heart valve, etc.).

 -  Patient with a history of rhinological pathology or a sense of smell problem.

 -  Patient with known neurological, psychiatric or neuroradiological manifestation.The
 subject is participating in a category 1 interventional study, or is in a period of
 exclusion determined by a previous study

 -  The subject is unable to express consent

 -  It is impossible to give the subject informed information

 -  The patient is under safeguard of justice or state guardianship

 -  Patient is pregnant, parturient or breastfeeding