Help in the Emergency Room to Detect Organ Dysfunction
Help in the Emergency Room to Detect Organ Dysfunction
The purpose of this prospective, non-interventional clinical study is to assess the clinical
 validity of a number of markers (including Heparin Binding Protein (HBP), Procalcitonin
 (PCT), C-reactive protein (CRP), White cell count (WCC) and lactate) for indicating the
 presence of organ dysfunction, or outcome, of patients with organ dysfunctions following
 emergency department admission or hospitalization. Secondary objectives are to identify novel
 putative biomarkers and to identify risk factors for negative long-term effects of acute
 critical illness The HBP assay is an enzyme-linked immunosorbent assay (ELISA) for the
 quantitative determination of Heparin Binding Protein in human plasma.
Inclusion Criteria:

 i) ≥18 years of age ii) 1 or more of the following criteria: Saturation<90% without oxygen
 or <93% with oxygen or reported saturation<90%, Respiratory frequency >25/min, Altered
 mental awareness, Heart rate >120/min, Systolic blood pressure <100 mm Hg. iv) informed
 consent.

 Exclusion Criteria:

 None