Study In Adolescent And Adult Subjects 12 Years Of Age And Older With Seasonal Allergic Rhinitis To Assess Onset of Action
Study In Adolescent And Adult Subjects 12 Years Of Age And Older With Seasonal Allergic Rhinitis To Assess Onset of Action
Allergic rhinitis is an inflammatory disorder of the upper airway that occurs following
 allergen exposure. The focus of this study, seasonal allergic rhinitis (SAR), is one type of
 allergic rhinitis that is triggered by the pollen from trees, grasses, and weeds. Commonly
 referred to as "hay fever", it is characterized by sneezing, nasal congestion and pruritus,
 rhinorrhea, and pruritic, watery, red eyes. The purpose of this study is to evaluate the
 onset of action of an investigational nasal spray, GW685698X aqueous nasal spray, versus
 vehicle placebo nasal spray in the treatment of seasonal allergic rhinitis caused by ragweed
 following a single dose of treatment in controlled pollen concentrations in an allergen
 challenge chamber.
Randomized, Double Blind, Placebo-Controlled, Single-Dose, Parallel-Group Study to Evaluate
 the Onset of Action of a Single Dose of Intranasal GW685698X Aqueous Nasal Spray 100 mcg in
 Adolescent and Adult Subjects (=12 years of age) With Seasonal Allergic Rhinitis Exposed to
 Ragweed Pollen in an Allergen Challenge Chamber
Inclusion criteria:

 -  Informed consent

 -  Outpatient

 -  Females must use appropriate contraception

 -  Diagnosis of seasonal allergic rhinitis

 -  Able to comply with study procedures

 -  Literate

 Exclusion criteria:

 -  Significant concomitant medical condition

 -  Use of corticosteroids, allergy medications, or tobacco

 -  Clinically significant abnormal ECG

 -  Laboratory abnormality

 -  Positive pregnancy test

 -  Allergy to any component of investigational product