CT Pancreas Perfusion
CT Pancreas Perfusion
1. Pancreatic CT perfusion with a biofeedback breathing belt worn by the participant, and
 using novel post-processing techniques, is a reliable method which can be used to
 differentiate between pancreatic cancer, chronic pancreatitis, and autoimmune
 pancreatitis.

 2. Pancreatic CT perfusion can be used to monitor patients undergoing decompression
 treatment (endoscopic retrograde cholangiopancreatography with stent placement) for
 painful chronic pancreatitis, and the change in the pancreatic perfusion parameters
 correlate with the change in the pain parameters (pain scale and analgesic use).

 3. Pancreatic CT perfusion parameters can be calculated using surrogate scan data sets at
 specific time points to replace the continuous scanning.
Inclusion Criteria:

 1. a. Suspected pancreatic adenocarcinoma, age 35 to 99 years.

 2. a. Chronic pancreatitis with chronic pain, age 18 to 99 years. Must be a confirmed
 diagnosis by either CT, endoscopic ultrasound (EUS), or endoscopic retrograde
 cholangiopancreatography (ERCP).

 2b. To undergo endoscopic or surgical decompression with 0 to 10 days of first study visit
 CT perfusion scan.

 2c. To answer pain questionnaire before first CT perfusion scan.

 2d. To return within three weeks to three months after decompression treatment for another
 CT perfusion scan and complete the second pain questionnaire.

 3a. Autoimmune pancreatitis, age 18 to 99 years either with diffuse or focal swelling of
 the pancreas confirmed by CT, MRI, or EUS or

 3b. Irregular narrowing of the pancreatic duct on ERCP and either elevated serum
 immunoglobulin G4 (IgG4), or histological confirmation.

 Exclusion Criteria:

 1a. Pancreatic ductal adenocarcinoma tumors with vascular involvement but without vascular
 occlusion.

 1. b. Pancreatic ductal adenocarcinoma tumors less than 2 cm in size.

 2. a. Chronic pancreatitis with diffuse and extensive pancreatic calcification.

 3. a. Autoimmune pancreatitis with a prior pancreas surgery or steroid treatment for
 autoimmune pancreatitis .

 Any Cohort:

 4. Pregnant.

 5. Prior iodine contrast reactions.

 6. Iodine allergy.

 7. Decreased kidney function being a serum creatinine greater than 1.5mg/dl.

 8. Any contraindication to having a CT scan with iodine contrast.