Study on 30 Outpatients With Chronic Migraine Treated With Well-Being Therapy or With a Control Therapy
Study on 30 Outpatients With Chronic Migraine Treated With Well-Being Therapy or With a Control Therapy
Chronic migraine is a disabling type of migraine and is often resistant to treatment.
 Non-pharmacological interventions have been investigated as potential treatment although,
 unfortunately, the literature on their efficacy is poor and showed mixed results. Well-Being
 Therapy (WBT) is a brief psychotherapy which has shown efficacy in decreasing the relapse
 rates of depression in adults, in generalized anxiety disorder and in cyclothymia. It can be
 implemented to empower psychological well-being. The aim of the present study is to test the
 efficacy of WBT in a sample of patients with chronic migraine to verify if it reduces the
 disability due to migraine and distress, it increases the psychological well-being as well as
 the level of euthymia.
Chronic migraine is a disabling type of migraine and is often resistant to treatment.
 Non-pharmacological interventions have been investigated as potential treatment although,
 unfortunately, the literature on their efficacy is poor and showed mixed results. The
 psychological interventions tested up to now are the Acceptance and Commitment Therapy and
 the Mindfulness. Well-Being Therapy (WBT) is a brief psychotherapy which has been manualized
 in 2016 and has shown efficacy in randomized clinical trials. It showed to be effective in
 decreasing the relapse rates of depression in adults, it showed to be effective in
 generalized anxiety disorder and in cyclothymia. Thus, psychological well-being can be
 implemented and empowered via a specific psychotherapy and this implementation might produce
 a protecting effect, thus favoring prevention. The aim of the present study is to test the
 efficacy of WBT in a sample of patients with chronic migraine. First the efficacy of WBT will
 be verified in terms of disability due to migraine. Then, the efficacy of WBT will be
 measured in terms of psychological well-being, euthymia, and distress. For this purpose, 30
 chromic migraine outpatients will be enrolled in a randomized, controlled, open clinical
 study.
Inclusion criteria:

 1. able and interested in participating to the present research project, as proved by
 signed Informed consent;

 2. 18-65 years of age;

 3. Italian mother tongue;

 4. diagnosis of chronic migraine according to the International Classification of
 Headache Disorders. Thus, presenting specific features (i.e., unilateral and pulsating
 pain of moderate or severe intensity, which is aggravated or precipitated by routine
 physical activities and is combined with nausea and/or vomiting, photophobia, and
 phonophobia) and migraine headache on ≥ 15 days per month;

 5. headache chronicity for a minimum of 1 year and pattern of headache symptoms stable
 for a period of at least 6 months;

 6. no pharmacological therapy or dietary supplements use for chronic migraine OR
 pharmacological therapy/dietary supplement use for chronic migraine stable since at
 least 3 months;

 7. psychotropic medication allowed only if stable since at least three months.

 Exclusion criteria:

 1. diagnosis of medication overuse headache;

 2. co-occurrence of psychiatric disorder(s) according to the Diagnostic and Statistical
 Manual of mental disorders (DSM) 5th edition as diagnosed via the MINI International
 Neuropsychiatric Interview;

 3. co-occurrence of chronic unstable medical conditions;

 4. being pregnant or lactating;

 5. under exogeneous hormones treatment (i.e., hormonal contraceptives, postmenopausal
 hormone therapy);

 6. any other condition that, according to the Investigators' opinion, may alter the
 ability of the patient to follow study procedures.