Impact of Lung Flute Therapy on Asthma
Impact of Lung Flute Therapy on Asthma
We hypothesized that the ability of the Lung Flute to enhance mucus clearance from the lower
 airways could be used to improve asthma control, if the device is used on a chronic basis.
 The primary end point of the study is the comparison of Asthma Control Test (ACT) - a
 validated questionnaire for asthma control and exhaled NO before, during and after using the
 lung flute. Several secondary end points were assessed for efficacy and safety, including
 health status, spirometric lung function, "stepping down" controller therapy and daily
 albuterol use.
This is a 3 month open label study. We plan to enroll 48 subjects with asthma at the Buffalo
 General Medical Center Allergy Clinic or the office of Dr. James Cumella. Inclusion criteria
 includes: at least 12 years of age, diagnosis of asthma and no current or previous history of
 smoking. Exclusion criteria includes: exacerbation of asthma or hospitalization for asthma
 within 8 weeks prior to enrollment, predominant chronic obstructive pulmonary disease (COPD)
 and bronchiectasis by clinical and/or radiological assessment, history of cough syncope,
 pregnant or nursing women, and inability to comply with study procedures.
Inclusion Criteria:

 -  at least 12 years of age

 -  diagnosis of asthma and no current or previous history of smoking.

 Exclusion Criteria:

 -  exacerbation of asthma or hospitalization for asthma within 8 weeks prior to
 enrollment

 -  predominant COPD and bronchiectasis by clinical and/or radiological assessment

 -  history of cough syncope

 -  pregnant or nursing women

 -  not fluent in English

 -  inability to comply with study procedures.