The Treatment of Hepatocirrhosis and Portal Hypertension
The Treatment of Hepatocirrhosis and Portal Hypertension
This study compare the efficiency of partial splenic embolization +endoscopical therapy with
 endoscopical therapy alone in gastroesophageal variceal haemorrhage accompanied with
 splenomegaly or hypersplenism of hepatocirrhosis and portal hypertension treatment.
Endoscopic therapy is the mature treatment of gastroesophageal variceal haemorrhage and PSE
 is an effective method for treatment of the hypersplenism and portal hypertension. Existing
 researches show that endoscopic therapy + PSE is more effective than endoscopic therapy alone
 in prevention of esophageal varices bleeding recurrence in the patients with liver cirrhosis.
 However, there is few articles which proved long-term effectiveness of endoscopic therapy +
 PSE, it needs further research on this issue. This study compares the efficiency of partial
 splenic embolization +endoscopic therapy with endoscopic therapy alone in the treatment of
 gastroesophageal variceal haemorrhage accompanied with splenomegaly or hypersplenism in the
 patients with hepatocirrhosis and portal hypertension.
Inclusion Criteria:

 -  At the risk of gastroesophageal variceal hemorrhage; Acute gastroesophageal variceal
 hemorrhage;Haematemesis and/or melena result in gastroesophageal variceal haemorrhage
 of liver cirrhosis in the past.

 -  Splenomegaly or hypersplenism acting as thrombocytopenia (PLT < 75000 cells/mm^3).

 -  Consent form must be signed by patients or their guardians before entering the test.

 Exclusion Criteria:

 -  History of liver surgery or spleen surgery and liver cancer.

 -  Existence of gastrointestinal endoscopic therapy contraindication;Hemorrhagic shock
 has not be corrected;Hepatic encephalopathy.

 -  Sinus bradycardia, bronchial asthma, chronic obstructive pulmonary disease, heart
 failure, low blood pressure, atrioventricular block, insulin dependent diabetes,
 peripheral vascular disease, liver function Child - Pugh class C.

 -  Pregnant women and nursing mothers.