SpareBrain - Mechanisms and Prevention of Secondary Brain Injury in Subarachnoid Haemorrhage
SpareBrain - Mechanisms and Prevention of Secondary Brain Injury in Subarachnoid Haemorrhage
Subarachnoidal hemorrhage (SAH) is a cause of long-term disability and death. Annually about
 1000 people in Finland suffer from SAH, their average age being under 50 years. SAH has a
 mortality rate of 12 % acutely and 40 % of patients die within a month from admission to
 hospital. In addition, 30 % of the surviving patients remain with neurological deficits. Most
 survivors of the primary insult suffer from secondary injury during the first 2-3 weeks from
 the insult.

 Despite the advances in neurosurgical and -radiological techniques and intensive care, the
 mortality and morbidity rates in SAH have not changed in recent years. There is still only
 limited understanding of the mechanisms of secondary insults causing brain injury after SAH.

 In this study the investigators are aiming to clarify the timescale and mechanisms
 contributing to the secondary insults. The investigators also explore usability of novel
 biomarkers to guide treatment of the patients suffering from SAH.
Subarachnoidal hemorrhage (SAH) is a cause of long-term disability and death. Annually about
 1000 people in Finland suffer from SAH, their average age being under 50 years. SAH has a
 mortality rate of 12 % acutely and 40 % of patients die within a month from admission to
 hospital. In addition, 30 % of the surviving patients remain with neurological deficits. Most
 survivors of the primary insult suffer from secondary injury during the first 2-3 weeks from
 the insult.

 Despite the advances in neurosurgical and -radiological techniques and intensive care, the
 mortality and morbidity rates in SAH have not changed in recent years. There is still only
 limited understanding of the mechanisms of secondary insults causing brain injury after SAH.

 In this study the investigators are aiming to clarify the timescale and mechanisms
 contributing to the secondary insults. The investigators also explore usability of novel
 biomarkers to guide treatment of the patients suffering from SAH.
Inclusion Criteria:

 -  aneurysmal subarachnoid haemorrhage

 Exclusion Criteria:

 -  age under 18 years

 -  pregnant

 -  moribund patient