A Study to Assess Current Standard Malaria Treatment Guidelines in the Republic of the Sudan
A Study to Assess Current Standard Malaria Treatment Guidelines in the Republic of the Sudan
This is a randomized controlled trial to assess the efficacy and safety of the national
 malaria treatment guidelines, asses the efficacy and safety of artesunate and sulphadoxine -
 pyrimethamine (AS+SP) for treatment in uncomplicated P. falciparum and P. vivax malaria and
 the hematologic effect of 14 days routine primaquine based radical cure in patients suffering
 from a P. vivax or mixed infection.
Inclusion Criteria:

 -  Age ≥ 12 months

 -  P. vivax or P. falciparum mono-infection or P. vivax / P. falciparum mixed infection

 -  Presence of axillary temperature ≥ 37.5°C or history of fever during the past 24 hrs

 -  Able to tolerate oral medication

 -  Able and willing to comply with the study protocol for the duration of the study

 -  Informed consent from the patient or from a parent or guardian in the case of children

 Exclusion Criteria:

 -  Bodyweight ≤5kg

 -  Presence of general danger signs in children aged under 5 years or signs of severe
 malaria in any patient according to the definitions of WHO

 -  Presence of severe malnutrition

 -  Acute anaemia <8g/dL

 -  Regular medication, which may interfere with antimalarial pharmacokinetics

 -  History of hypersensitivity reactions or contraindications to any of the drug(s)
 tested or used as alternative treatment(s)

 -  A positive pregnancy test or lactating.