r-tPA Thrombolytic Therapy in Combination With Remote Ischemic Conditioning for Acute Ischemic Stroke Recovery
r-tPA Thrombolytic Therapy in Combination With Remote Ischemic Conditioning for Acute Ischemic Stroke Recovery
to detect the efficiency and safety of intravenous rtPA combined with RIPC in acute ischemic
 stroke patients
Remote ischemic post-conditioning, which consists of several brief cycles of intermittent
 ischemia-reperfusion of the arm or leg, may potentially confer a powerful systemic protection
 against prolonged ischemia in a distant organ. Numerous reports have confirmed it strongest
 endogenous neuroprotection against brain injury after stroke. Ren et al demonstrated that
 remote ischemic post-conditioning (RIPC) performed in the hind limbs can not only
 significantly reduce the stroke volume within 3 hours in rat model, but also ameliorate the
 outcome of the behavioral test. A long-term repeated RIPC therapy can also help improving
 neurological functions. A combination of RIPC and tPA can help with neuroprotection which
 improves the neurological functions. Thus, it is meaningful to transform these basic
 experimental results to the clinical treatment. In the RECAST-1 trial, RIC has shown it
 safety and efficiency in AIS patients without tPA. However, there is no further explanation
 for the patients with IVT. Thus, in this study, we aim to demonstrate the efficiency and
 safety of RIPC in AIS patients performed rt-PA within 4.5 hours.
Inclusion Criteria:

 -  Male or female, age≥18;

 -  Clinical sign and symptoms consistent with the diagnosis of an acute ischemic stroke,
 onset of stroke symptoms within 4.5 h before initiation of intravenous rt-PA
 thrombolytic therapy;

 -  Baseline National Institutes of Health Stroke Scale (NIHSS) score of 4-15 (assessed
 before intravenous alteplase), mRS ≤1 before onset of stroke symptom;

 -  No contraindication for MRI.

 -  Informed consent obtained

 Exclusion Criteria:

 -  Cardioembolism；

 -  Contraindication for remote ischemic conditioning: severe soft tissue injury,
 fracture, or peripheral vascular disease in the upper limbs;

 -  Life expectancy < 1 year;

 -  Pregnant or breast-feeding women;

 -  Unwilling to be followed up or poor compliance for treatment; (5) Patients being
 enrolled or having been enrolled in other clinical trial within 3 months prior to this
 clinical trial.