Fiber-rich Foods to Treat Obesity and Prevent Colon Cancer
Fiber-rich Foods to Treat Obesity and Prevent Colon Cancer
The study will target a population at high risk for colorectal cancer, overweight and obese
 participants with a history of a colon polyp in the past 3 years to test whether a
 high-legume, high-fiber diet will simultaneously increase weight loss and suppress intestinal
 biomarkers of cancer risk compared to a control diet (healthy American). In addition, it will
 explore potential mechanisms through which the high-legume intervention diet facilitates
 weight loss and intestinal health.
The goal of the research is to conduct a clinical trial featuring study-provided
 pre-portioned entrées (2 entrées per day months 1-3, 1 entrée per day months 4-6) and
 strategic nutritional instruction to guide participants to integrate legumes into a healthy
 high-fiber diet pattern. The research will target a population at high risk for colorectal
 cancer, overweight and obese participants with a history of a colon polyp in the past 3
 years, to test whether a high-legume, high-fiber diet will simultaneously increase weight
 loss and suppress intestinal biomarkers of cancer risk compared to a control diet (healthy
 American). In addition, it will explore potential mechanisms through which the high-legume
 intervention diet facilitates weight loss and intestinal health.
Inclusion Criteria:

 -  free-living adults 40-75 yrs. old

 -  BMI 25-40 kg/m2

 -  colonoscopy within 3 years that found ≥1 adenoma >0.5 cm

 -  English speaking,

 -  ambulatory, able to pick up food, participate in clinical exams and laboratory tests -
 able to provide informed consent

 Exclusion Criteria:

 -  serious medical condition (e.g., cancer, heart disease, kidney disease, diabetes,)

 -  history of CRC, bowel resection, polyposis syndrome, or inflammatory bowel disease

 -  smoked regularly in the past year

 -  dietary restrictions substantially limiting compliance (e.g., must be willing to be
 randomized to either diet)

 -  planning on substantially changing usual exercise behavior in the next 6 mos

 -  regular use of medication that may alter inflammation markers, insulin, glucose, or
 gut function (e.g., non-steroidal anti-inflammatory drugs, antibiotics, insulin,
 steroids)

 -  pregnant women, breast feeding women, or women planning pregnancy within the year of
 active study participation