Clinical Study of Albumin-bound Paclitaxel Plus Nedaplatin in Cervical Cancer
Clinical Study of Albumin-bound Paclitaxel Plus Nedaplatin in Cervical Cancer
Using albumin-bound paclitaxel and nedaplatin in the advanced or recurrent metastasis
 cervical cancer, to evaluate the efficacy and toxic reaction.
Albumin-bound paclitaxel is a novel, solvent-free, albumin-bound nanoparticle form of
 paclitaxel designed to avoid problems associated with solvents used in Taxol. And
 albumin-bound paclitaxel was characterized with high tolerated doses with greater efficacy,
 and with greater concentration in tumor tissue compared with normal tissues. This is a single
 center, non-randomized, open-label Phase II clinical study to investigate the efficacy and
 tolerability of albumin-bound paclitaxel plus nedaplatin in patients with advanced, recurrent
 metastatic cervical cancer. About 30 patients will receive 175-200 mg/m2 albumin-bound
 paclitaxel, d 1 combined with 80- 100 mg/m2 nedaplatin, d 2, every 3 weeks. At least 2 cycles
 will be completed for each patient, for whom responded to the treatment, 4-6 cycles will be
 completed.
Inclusion Criteria:

 -  Cervical cancer, advanced or recurrent metastasis

 -  Measurable and assessible tumor lesions

 -  Used ordinary paclitaxel or platinum drugs, more than 28 days

 -  Aged 18-70

 -  KPS score> 60 points, expected to survive more than 3 months

 -  Normal bone marrow function

 -  The function of liver and kidney had no obvious damage

 -  Normal function of vital organs

 -  No brain metastases

 -  Patients or their agents to sign informed consent

 -  Compliance, and can be followed up regularly

 Exclusion Criteria:

 -  Brain metastases

 -  Serious complications

 -  Acute inflammatory response

 -  Combined with other tumor

 -  Pregnancy or breast-feeding women

 -  Vertebral metastasis with nerve compression symptoms

 -  Large volume of pleural effusion, pericardial effusion

 -  Other malignancy within five years

 -  Drug allergy

 -  Other chemotherapy contraindications

 -  The possibility of pregnancy, and not willing to contraception

 -  No measurement of lesion

 -  Mental illness which is difficult to control