Spinal Cord Stimulation for the Treatment of Motor and Nonmotor Symptoms of Parkinson's Disease
Spinal Cord Stimulation for the Treatment of Motor and Nonmotor Symptoms of Parkinson's Disease
Although DBS improves patient's quality of life advanced Parkinson's patients (PD) by
 addressing the cardinal symptoms and reducing levodopa motor complications, symptoms still
 worsen over time. Postural problems, frequent falls, freezing of gait impairment and other
 locomotion difficulties still remain as important causes of disability and incapacity. Novel
 therapeutics approaches are needed to restore quality of life (QoL).

 This study aims to explore the effects of spinal cord stimulation in locomotion, falls and
 freezing of gait in advanced PD patients.

 Twenty PD patients will undergo thoracic spinal cord stimulation at high frequencies in a
 prospective study for six months.

 Changes in locomotion capacity and freezing of gait rating will be the primary out come.
 Secondary outcomes will be: QoL and common motor outcome measures in PD patients. Always
 comparing the status before, one, three and six months after stimulation was initiated. A
 double blind trial will be performed within three months of follow up (high X low frequency
 stimulation).
Background: Currently there are no available Parkinson's disease (PD) therapy can really stop
 disease progression. Although Deep Brain Stimulation (DBS) improves patient's quality of life
 by addressing the cardinal symptoms and reducing Levodopa motor complications, non motor
 symptoms still increasing over time. Gait problems as falls and freezing are important cause
 of disability and incapacity. Novel therapeutics approaches are needed to restore quality of
 life. Data from animal PD model suggest that spinal cord stimulation (SCS) can enhance
 locomotion in mice. Although clinical results, mostly from case reports, in PD patients are
 still conflicting, a few patients benefited from SCS in thoracic levels.

 Aim: Evaluated Spinal cord stimulation effects in locomotion, gait, freezing and falls in PD
 patient's.

 Method: 20 PD patients will undergo thoracic spinal cord stimulation with high frequency in a
 prospective study for six months. Gait and freezing evaluation will consists in: timed up and
 go test, timed up and go test with dual task, 20 m walk test, 20 m walk test with obstacle,
 freezing of gait scale and falls scale. PDQ 39 and Schwab and England scales will be used to
 measure quality of life. Unified Parkinson's Disease Rating Scale for motor symptoms and
 general evaluation. All tests will be done before surgery, after one week, one, three, six
 months. All patients will be stimulated with the same parameters: High frequencies and 90 mcs
 pulse width and the sensory threshold will be measured. At the third month the parameters of
 SCS will be changed and comparative tested for low frequency in a double blind trail.
Inclusion Criteria:

 1. Idiopathic PD

 2. Gait and locomotion problems as the main complain/symptom

 3. PD patients with or without DBS

 4. Hoehn and Yahr scale equal or more than 2.0

 Exclusion Criteria:

 1. Dementia

 2. Hoehn and Yahr scale more than 4

 3. Less than 5 years of Parkinson's disease symptoms

 4. General contraindications of surgery