Analysis of CMV Infections in Patients With Brain Tumors or Brain Metastases During and After Radio(Chemo)Therapy
Analysis of CMV Infections in Patients With Brain Tumors or Brain Metastases During and After Radio(Chemo)Therapy
Radio(chemo)therapy is the standard therapy for both, brain tumors and brain metastases.
 Neurological decline is observed in these patients and tumor progression or radiotherapy side
 effects have been made responsible for this. However CMV encephalitis may also be a reason.
 Therefore the investigators aim to analyze the CMV status in patients during and after
 radio(chemo)therapy. It will be checked by CMV-DNA (PCR analysis) and CMV antibodies (IgG and
 IgM ELISA) in the blood of the patients. These findings will be correlated with changes in
 the brain, visualized by MRI. In addition a detailed immunophenotyping in the peripheral
 blood will be performed.
Inclusion Criteria:

 -  brain tumours (glioblastoma or anaplastic astrocytoma)

 -  brain metastases from diagnosed primary tumours

 -  legal age

 -  planned chemoradiation and adjuvant chemotherapy [metastases]

 -  planned chemoradiation and adjuvant chemotherapy with temodal (according to Stupp et.
 al.) [brain tumors]

 Exclusion Criteria:

 -  fertile patients who refuse effective contraception during study treatment

 -  persistent drug and/or alcohol abuse

 -  patients not able or willing to behave according to study protocol

 -  patients in care

 -  patients that are not able to speak German

 -  patients with claustrophobia

 -  patients with artificial joint or any metal parts in the body

 -  patients with pacemakers