Role of CCL2 in Alcoholic Liver Diseases
Role of CCL2 in Alcoholic Liver Diseases
Immune dysregulations, including cytokines and chemokines secretions occurs in alcoholic
 liver disease. Serum levels and liver expression of CCL2 are increased in patients with
 alcoholic hepatitis but the role of this chemokine in the pathogenesis of alcoholic liver
 disease is nevertheless unknown. The aim of the study is to analyze plasma level and liver
 expression of CCL2 and their relation with liver disease severity and inflammatory infiltrate
 in our cohort of alcoholic patients. We studied also the association between -2518 CCL2
 polymorphism and the severity of alcoholic liver disease.
ALD patients

 Inclusion Criteria:

 -  Excess alcohol intake

 -  Abnormality of liver biopsy compatible with alcoholic aetiology

 -  Caucasian ethnicity

 Exclusion Criteria:

 -  Presence of any other chronic liver disease

 -  co-infection with HIV Controls Inclusion criteria

 -  Caucasian ethnicity

 -  presence of a disease