Early TIPS With Polytetrafluoroethylene (PTFE) Covered Stents for Acute Variceal Bleeding in Patients With Advanced Cirrhosis
Early TIPS With Polytetrafluoroethylene (PTFE) Covered Stents for Acute Variceal Bleeding in Patients With Advanced Cirrhosis
The purpose of this study is to determine whether early use of transjugular intrahepatic
 portosystemic shunt (TIPS) with Polytetrafluoroethylene (PTFE) covered stents is able to
 prolong the survival in patients with advanced cirrhosis and acute variceal bleeding.
Inclusion Criteria:

 -  History of cirrhosis (clinical or by liver biopsy)

 -  Admission due to acute bleeding from oesophageal or gastric (GOV1 or GOV2) varices

 -  Child-Pugh Class C (Child-Pugh score less than or equal to 13) or Child-Pugh class B

 -  Signed written informed consent

 Exclusion Criteria:

 -  Patients not fulfilling inclusion criteria

 -  Pregnancy or breast-feeding

 -  Confirmed hepatocellular carcinoma

 -  Creatinine greater than 3 mg/dl

 -  Terminal hepatic failure (Child-Pugh score greater than 13)

 -  Previous treatment with TIPS or combined pharmacological and endoscopic treatment to
 prevent rebleeding

 -  Fundal or ectopic gastric variceal bleeding (IGV1 or IGV2)

 -  Complete portal vein thrombosis or portal cavernoma

 -  Congestive heart failure New York Heart Association (NYHA) greater than III or medical
 history of pulmonary hypertension

 -  Spontaneous recurrent hepatic encephalopathy