The Effects of Ankle Foot Orthoses on Gait Efficiency in Children With Acute Lymphoblastic Leukemia and Foot Drop
The Effects of Ankle Foot Orthoses on Gait Efficiency in Children With Acute Lymphoblastic Leukemia and Foot Drop
This study is designed to see if children with acute lymphoblastic leukemia who have
 developed foot drop during treatment for their leukemia consume less oxygen when walking with
 or without an ankle brace designed to support their foot during walking. In this study
 children with foot drop are asked to walk for six minutes with and without brace on their
 ankle. During each walk, the amount of oxygen used is measured. The child wears a face mask
 which is attached to a device that records how much oxygen they use. The amount of oxygen
 used during the walk with the brace on will be compared to the amount of oxygen used with the
 brace off.
1. This study will determine the impact of Ankle Foot Orthoses (AFO) wear on gait
 efficiency in children with ALL and Chemotherapy-Induced Peripheral Neuropathy (CIPN).

 2. The study hypothesizes that children with CIPN will have lower net oxygen consumption
 during the six minute walk test while wearing AFO as compared to their net oxygen
 consumption during a six minute walk test while not wearing AFO.

 3. The study will assess whether gait efficiency while using an AFO persists after one
 month of use.

 4. The study will hypothesize that the benefits of AFO use on gait efficiency persist after
 one month of wear.
Inclusion Criteria:

 1. Research participant is diagnosed with childhood ALL and currently being treated on
 the TOTAL XVI protocol at St. Jude Children's Research Hospital (SJCRH)

 2. Research participant is from 6 to 18 years of age at the time of the scheduled
 evaluation

 3. Research participant has chemotherapy-induced peripheral neuropathy resulting in foot
 drop

 4. Research participant will be receiving AFO

 5. Research participant has a hemoglobin level greater than 8 g/dL and a platelet count
 above 50 x 109/L

 Exclusion Criteria:

 1. Participant has Down Syndrome or other known congenital developmental delays

 2. Participant has a platelet count lower than 50 x 109/L and a hemoglobin level less
 than 8 g/dL

 3. Participant has a lower extremity amputation, congenital deformity of the lower limb
 or an acute fracture of the lower limb

 4. Participant has symptomatic osteonecrosis in the lower extremities