Radical Versus Simple Hysterectomy and Pelvic Node Dissection With Low-risk Early Stage Cervical Cancer
Radical Versus Simple Hysterectomy and Pelvic Node Dissection With Low-risk Early Stage Cervical Cancer
The reason this study is being done is to see if a simple hysterectomy is as good as a
 radical hysterectomy in preventing cancer of the cervix from returning, and whether, because
 less tissue surrounding the uterus is removed during surgery, there are fewer side-effects
 after the surgery and in the long-term.
At this time, it is not clear which of these approaches best balances the desire to prevent
 cancer of the cervix from returning with the risks of side effects after surgery and in the
 long-term.
Inclusion Criteria:

 -  Histologically confirmed adenocarcinoma, squamous, or adenosquamous cancer of the
 cervix. Diagnosis has been made by LEEP, cone or cervical biopsy and has been reviewed
 and confirmed by the local reference gynecological pathologist.

 -  Patient has been classified as low-risk early-stage cervical cancer. These patients
 include:

 • FIGO Stage IA2 [FIGO Annual Report, 2009], defined as:

 o evidence of disease by microscopy;

 -  for patients who underwent a LEEP or cone:

 -  histologic evidence of depth of stromal invasion > 3.0 and ≤ 5.0 mm based on the
 local reference pathologist's measurement of the LEEP or cone specimen;

 -  histologic evidence of lateral extension that is ≤ 7.0 mm based on the local
 reference pathologist's measurement of the LEEP or cone specimen; and

 -  negative margins (patients with positive margins are considered IB1, see below)

 -  for patients who underwent a cervical biopsy only:

 -  radiologic evidence of less than 50% stromal invasion based on pelvic MRI

 • FIGO Stage IB1 [FIGO Annual Report, 2009] with favorable (low risk) features,
 defined as:

 -  measured stromal invasion and lateral extension that meet the criteria for IA2
 (see above) but with positive margins;

 -  evidence of disease by clinical exam; lesion must clinically measure ≤ 20 mm

 -  evidence of disease by microscopy;

 -  for patients who underwent a LEEP or cone:

 -  histologic evidence of depth of stromal invasion between 5.1-10 mm and/or lateral
 extension between 7.1-20.0 mm based on the local reference pathologist's
 measurement of the LEEP or cone specimen

 -  for patients who underwent a cervical biopsy only:

 -  radiologic evidence of less than 50% stromal invasion based on pelvic MRI

 -  lateral extension ≤ 20 mm based on clinical exam or radiologic imaging.

 In addition to above criteria on maximal stromal invasion of ≤ 10 mm, the lesion must be no
 larger than 20 mm in any dimension by any assessment method (MRI, clinical or histological
 exam). To ensure patients meet this criterion, investigators may need to sum the lesion
 measurements from biopsy and other methods that evaluate it in the same plane.

 Patients are eligible irrespective of the presence or absence of lymph-vascular space
 involvement (LVSI).

 -  Physical examination, recto-vaginal examination and visualization of the cervix by
 speculum or colposcopic examination have been done after the initial diagnostic
 procedure (LEEP, cone or biopsy) and prior to randomization.

 -  Chest x-ray or CT scan of chest AND pelvic MRI* done after initial diagnostic
 procedure (LEEP, cone or biopsy) and prior to randomization.

 The CT should be a 16 slice (or higher) helical scanner. Oral and intravenous contrasts are
 preferred (unless there is a contraindication to the use of contrast) with scan obtained in
 the portal phase at a slice thickness of 5mm or lower Pelvic MRI should be performed on a
 1.5 or 3 Tesla magnet with pelvic phased-array coils. The MR pulse sequences will consist
 of T1 gradient echo in the axial plane at 5 mm slice thickness and fast spin echo in the
 axial, sagittal, and coronal planes at 4 mm slice thickness. The short axis (perpendicular
 to the tumour's long axis) with a 3 mm slice thickness is required in the best plane to
 show the maximum thickness of stromal invasion. Use of an anti-peristaltic agent is
 mandatory while intravenous use of gadolinium or diffusion-weighted imaging (DWI) is
 optional.

 * Note: pelvic MRI is optional if the patient has stage IA2 disease and underwent a LEEP or
 cone.

 -  After consideration of a patient's medical history, physical examination and
 laboratory testing, patients must be suitable candidates for surgery as defined by the
 attending physician / investigator.

 -  Patients must have no desire to preserve fertility.

 -  Patients fluent in English or French must be willing to complete the Quality of Life
 Questionnaire. The baseline assessments must be completed within 6 weeks prior to
 randomization. Inability (illiteracy in English or French, loss of sight, or other
 equivalent reason) to complete the questionnaires will not make the patient ineligible
 for the study. However, ability but unwillingness to complete the questionnaires will
 make the patient ineligible. As additional GCIG groups join the study, more
 translations of some of the questionnaires may be added.

 Patients fluent in English or French who reside in Canada and the United Kingdom must agree
 to participate in the economic evaluation component of this trial and complete the Health
 Economics Questionnaire. Similarly, patients fluent in English or French accrued from other
 GCIG groups who are participating in the economic evaluation must be willing to complete
 the Health Economics Questionnaires.

 -  Patient consent must be appropriately obtained in accordance with applicable local and
 regulatory requirements. Each patient must sign a consent form prior to enrolment in
 the trial to document their willingness to participate.

 -  Patients must be accessible for treatment and follow-up. Investigators must assure
 themselves the patients randomized on this trial will be available for complete
 documentation of the treatment, adverse events, and follow-up.

 -  Surgery is to be done within 20 weeks of initial diagnosis (NO EXCEPTIONS). The
 20-week period includes time required for diagnosis, referral, diagnostic staging,
 randomization and scheduling of the surgical procedure.

 -  Patients must be ≥ 18 years old.

 Exclusion Criteria:

 -  Patients with FIGO 1A1 disease [FIGO Annual Report, 2009].

 -  History of other malignancies, except: adequately treated non-melanoma skin cancer,
 curatively treated in-situ cancer of the cervix, or other solid tumours, Hodgkin's
 lymphoma or non-Hodgkin's lymphoma curatively treated with no evidence of disease for
 > 5 years.

 -  Patients with evidence of lymph node metastasis on preoperative imaging or histology.

 -  Patients who have had or will receive neoadjuvant chemotherapy.

 -  Patients who are pregnant.