Evaluation of Symptom-specific Goal Achievement
Evaluation of Symptom-specific Goal Achievement
Lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) consists
 of a constellation of symptoms (including voiding, storage, and post-micturition). The impact
 of the LUTS on patients' health-related quality of life is substantial and multifaceted.
 Thus, the therapies aimed at treating BPH are concerned primarily with improving patients'
 symptoms, thereby improving quality of life. When multiple symptoms are present, the level of
 bother associated with individual symptoms varies and patients prioritize their treatment
 goals for symptom relief. A measure that addresses patients' most bothersome symptoms (MBS)
 and evaluation of symptom-specific goal achievements may lead to improved outcomes and
 patient satisfaction to the treatment. The objectives of this study were (1) to assess
 patient-reported MBS and symptom-specific goal achievements (PGA) with medical treatment in
 BPH patients, and (2) to identify factors that influence or have relation to the PGA.
Inclusion Criteria:

 -  males ≥50 years with LUTS secondary to BPH

 -  Moderate to severe LUTS : IPSS ≥ 8

 -  An enlarged prostate : TRUS ≥25 mL

 -  Decreased peak flow rate : Qmax ≤15mL/s (volume voided ≥ 120 mL)

 -  Having signed the informed consent to participate in the study.

 Exclusion Criteria:

 -  Post voided residual urine ≥ 200mL

 -  Patients performing catheterization

 -  Urinary tract infection patients

 -  Patients taking 5 alpha reductase inhibitor

 -  Known hypersensitivity to alfuzosin

 -  History of postural hypotension or syncope

 -  Hypertension patients treated with other alpha1-blockers

 -  Patients newly taking anticholinergic medication within 1 month

 -  Hepatic insufficiency (AST/ALT ≥ 2 times of normal range)

 -  Renal insufficiency (s-Cr ≥ 2mg/dL)

 -  Unstable angina pectoris

 -  Uninvestigated hematuria

 -  Serum PSA ≥ 4 ng/mL (biopsy proven no cancer patients can be included)

 -  Interstitial cystitis patients

 -  Severe concomitant condition threatening life.

 -  Patient who is unable to make voiding diary

 -  Bladder or prostate cancer patients

 -  Patients receiving prostate or bladder surgery