Phase II Proof of Concept Study in Uncomplicated UTI
Phase II Proof of Concept Study in Uncomplicated UTI
A study of the efficacy and safety of MPC-SHRC for the relief of symptoms associated with
 uncomplicated urinary tract infections.
Inclusion Criteria:

 -  Non-pregnant, nonlactating woman with moderate to severe symptoms of urinary tract
 infection

 -  On adequate birth control

 -  Normal ECG

 Exclusion Criteria:

 -  Participated in any other trial within 30 days of visit 1

 -  Known or suspected allergy to investigational drug

 -  Narrow angle glaucoma

 -  Recovering from chicken pox or flu-like symptoms

 -  History of peptic ulcer, gastrointestinal bleeding, gastrointestinal surgery, or
 gastrointestinal dysfunction which could interfere with drug absorption

 -  Taken any drugs for within past 24 hours for symptoms associated with uncomplicated
 urinary tract infections

 -  Currently taking prohibited drugs

 -  Taken an antibiotic within 7 days of Visit 1

 -  Are ineligible to receive an antibiotic

 -  History of urinary retention

 -  History of interstitial cystitis

 -  History of impaired renal function

 -  History of impaired hepatic function

 -  Diagnosis or suspicion of complicated urinary tract infection or systemic infection

 -  History of substance abuse