Ph. II Temozolomide + O6-BG in Treatment of Pts w Temozolomide-Resistant Malignant Glioma
Ph. II Temozolomide + O6-BG in Treatment of Pts w Temozolomide-Resistant Malignant Glioma
Objectives:

 To define role of O6-Benzylguanine (BG) in restoring Temodar (temozolomide) sensitivity in
 patients with Temodar-resistant malignant glioma.

 To further define toxicity of combo therapy using Temodar + BG.
2 separate strata accrued independently of each other: Stratum 1-patients with Glioblastoma
 Multiforme (GBM). Stratum 2-patients with Anaplastic Glioma [anaplastic astrocytoma (AA),
 anaplastic oligodendroglioma (AO), anaplastic mixed (AA and AO)] .

 BG at 120mg/m2 administered intravenously over 1 hour followed immediately by 48-hour
 infusion at 30mg/m2/24hrs. Temozolomide 472mg/m2 administered orally, in fasting state,
 within 60 minutes of end of the 1-hour administration of BG infusion. Treatment cycles may be
 repeated every 28 days following dose of Temodar from previous cycle.

 Temodar has been well tolerated by both adults and children with most common toxicity being
 mild myelosuppression. Other, less likely, potential toxicities include nausea and vomiting,
 constipation, headache, alopecia, rash, burning sensation of skin, esophagitis, pain,
 diarrhea, lethargy, hepatotoxicity, anorexia, fatigue and hyperglycemia. Hypersensitivity
 reactions have not yet been noted with Temodar. As in the case with many anti-cancer drugs,
 Temodar may be carcinogenic. BG toxicities include agitation, lethargy, nausea, vomiting,
 rapid heart rate, elevated liver functions, & leukemia; but, not with BG as single agent.
 Transient lymphopenia has been seen with BG as single agent.
Inclusion Criteria:

 -  Patients have recurrent/progressive Malignant Glioma (MG). Stereotactic biopsy at time
 of recurrence/progression is only required if radiation-induced necrosis is suspected

 -  Patients have MG resistant to Temodar, which is defined as > or = to 25 percent
 increase in tumor growth on contrast enhanced MRI/CT within 8 weeks of last dose of
 Temodar

 -  Age > or = to 18 years

 -  Evidence of measurable enhancing disease on contrast-enhanced MRI, unless medically
 contraindicated.

 -  Interval of at least 2 weeks between prior surgical resection/ 4 weeks between prior
 radiotherapy/chemotherapy, and enrollment on protocol unless there is unequivocal
 evidence of tumor progression. However, patients treated with chemotherapy agents such
 as VP-16 who would normally be retreated after shorter intervals may be treated at
 usual starting time even if less than 4 weeks from last prior dose of chemotherapy

 -  Karnofsky performance score > or = to 60 percent

 -  Hematocrit > 29 percent, absolute neutrophil count (ANC) > 1,500 cells/microliter,
 platelets > 100,000 cells/microliter

 -  Serum creatinine <1.5 mg/dl, Blood Urea Nitrogen (BUN) <25 mg/dl, Serum Glutamic
 Oxaloacetic Transaminase (SGOT) & bilirubin <1.5 x upper limit of normal (ULN)

 -  For patients on corticosteroids, they must have been on stable dose for 1 week prior
 to entry, if clinically possible, and dose should not be escalated over entry dose
 level

 -  Signed informed consent approved by Institutional Review Board (IRB) prior to patient
 entry

 -  If sexually active, patients will take contraceptive measures for duration of
 treatments

 Exclusion criteria:

 -  Pregnancy

 -  Co-medication that may interfere with study results