The Use of Capsaicin Challenge for Diagnosis, Monitoring and Follow-up of Chronic Cough.
The Use of Capsaicin Challenge for Diagnosis, Monitoring and Follow-up of Chronic Cough.
The purpose of this study is to determine whether the capsaicin challenge can improve the
 diagnosis, treatment, monitoring and follow-up in patients with chronic cough.
Capsaicin is administrated in incremental concentrations with two inhalations of normal
 saline solution. Patients are instructed to exhale to functional residual capacity and than
 to inhale through the mouthpiece for 1 second (single breath inhalation). The number of
 coughs in the first 10 seconds after each inhalation is counted. C2; the concentration of
 which the patient responded by 2 coughs, C5;the concentration of which the patient responded
 by 5 coughs. The challenge ends at C5.
Inclusion Criteria:

 -  Patients with persisting cough for more than 3 months, without known respiratory or
 lung diseases

 Exclusion Criteria:

 -  Diagnosis of respiratory or lung diseases of any kind