Bortezomib (Velcade) Post Allogenic Peripheral Blood Stem Cell Transplantation for Myeloma
Bortezomib (Velcade) Post Allogenic Peripheral Blood Stem Cell Transplantation for Myeloma
Primary Objective:

 1. To determine the antimyeloma effect of bortezomib after allogeneic transplantation for
 patients with multiple myeloma.

 Secondary Objective

 1. To determine the toxicity profile of bortezomib in patients with multiple myeloma
 undergoing allogeneic progenitor cell transplantation.
Bortezomib (velcade) is a new drug that works by blocking a structure in the cells called
 proteasome. This proteasome acts like a system that eliminates abnormal or old proteins from
 the cells. Cancer cells may be sensitive to drugs like bortezomib (velcade), because tumor
 cells have more abnormal proteins than normal cells. Bortezomib (velcade) enters the tumor
 cells and affects the way they divide. When cancer cells cannot divide, they die.

 You will have blood (about 2 tablespoons) and bone marrow testing done about every 2-3 months
 to determine your response and tolerance to treatment. To collect a bone marrow sample, an
 area of the hip or chest bone is numbed with anesthetic and a small amount of bone marrow is
 withdrawn through a large needle.

 You will receive bortezomib (velcade) as an infusion into a vein over 5-10 minutes twice a
 week for 2 weeks. You will then rest for 10 to 17 days. This 21-28 day period makes up 1
 cycle. You will complete up to a total of 4 cycles. Courses 2 and 3 might be given under
 supervision of your local physician however the principal investigator will do necessary
 treatment dose adjustments and new set of treatment orders will be provided to your
 physician. Treatment evaluations will be under the supervision of the principal investigator.

 You will have a physical exam and routine blood tests (about 2 tablespoons) before each dose
 of bortezomib (velcade). Blood (about 2 tablespoons) and urine tests to determine response to
 treatment will be performed once a month, as well as blood tests to look at side effects of
 treatment, will be performed at least once a week and more frequently if medically necessary.

 You will be taken off study if the disease gets worse or intolerable side effects occur. You
 will be called every 3 months for at least 1 year after the last dose of bortezomib (velcade)
 to see how you are doing.

 This is an investigational study. Bortezomib (velcade) is commercially available and
 indicated for the treatment of myeloma. A total of 28 patients will participate in this
 study. All will be enrolled at M. D. Anderson.
Inclusion Criteria:

 -  Patients with multiple myeloma at least 3 months post allogeneic transplant who either
 failed to achieve a complete remission or are relapsing.

 -  Allograft performed from a related donor who is HLA-compatible (5/6 or 6/6), or class
 I serologic match and class II molecular matched unrelated donor).

 -  Zubrod Points Scale (PS) < 2, life expectancy is not severely limited by concomitant
 illness.

 -  Patient willing and able to sign informed consent.

 -  Patients less than 70 years of age.

 Exclusion Criteria:

 -  Active Central Nervous System (CNS) disease.

 -  Uncontrolled acute or chronic Graft-versus-host disease (GVHD).