Effects of Respiratory Muscle Training and Respiratory Exercise in Exercise Tolerance, Performing Daily Life Activities and Quality of Life of Patients With Chronic Obstructive Pulmonary Disease
Effects of Respiratory Muscle Training and Respiratory Exercise in Exercise Tolerance, Performing Daily Life Activities and Quality of Life of Patients With Chronic Obstructive Pulmonary Disease
In patients with chronic obstructive pulmonary disease (COPD) breaths at an abnormally high
 lung volume causes the inspiratory muscle to operate at non-optimal lengths, which reduce
 their maximal contractile forces. In addition, causes non thoraco abdominal synchronize,
 reduced inspiratory muscle strength and is associated with dyspnea and decreased exercise
 capacity. For these patients inspiratory muscle training (IMT) is a widely employed form of
 rehabilitation also targeting the respiratory muscle. In addition, patients often experience
 shortness of breath and a decline in exercise tolerance, resulting in disability in the
 performance of activities of daily living (ADL). The aims of this trial are to evaluate the
 effects of inspiratory muscle training associated with aerobic training on strength and
 endurance of inspiratory muscle, thoracic abdominal synchrony, exercise tolerance and quality
 of life patients with COPD. To compare the responses with the effects of aerobic training
 plus exercises of the trunk and upper limbs, and stretching of large muscle groups of the
 trunk. To compare difference in the perception of dyspnea during the ADL set (Borg Scale)
 with perception of dyspnea self-reported in the Medical Research Council (MRC), the London
 Chest Activity of Daily Living (LCADL) and the Pulmonary Functional Status and Dyspnea
 Questionnaire - Modified version (PFSDQ-M) before start the protocol. To investigate changes
 on perception of dyspnea (Borg scale), metabolic and ventilatory responses during a standard
 set of ADL tasks after a physical training and to evaluate and compare changes on perception
 of dyspnea. The hypothesis are that the ventilatory efficiency during the performance of ADL
 and the dyspnea reported from borg scale, the LCADL and the PFSDQ-M that quantifies the
 functional performance (change in activity levels) are improved during the IMT in conjunction
 with general exercise training in patients with COPD. The MIT increases the strength and
 endurance of inspiratory muscle, the exercise capacity and the quality of life compared to
 the general physical training. However, compared to the thorax abdominal synchronizes, higher
 modification is verified in the general physical training group with specific exercise to
 torso, limbs and stretching of the higher muscle group.
Methodology Sample Is a prospective longitudinal. Forty patients with COPD to moderate to
 very severe obstruction (ratio [FEV1/FVC] <70%) and FEV1 <80% predicted (RABE et al., 2008),
 age ranging from 50 to 80 years old, both sexes will be assessed and treated. All subjects
 carry out spirometry before and after bronchodilator (BD) under medical supervision.

 Experimental Procedure Patients with COPD will undergo a physical assessment of general and
 specific respiratory system and receive guidance on the tests and treatments proposed in this
 study. All of them will be instructed to maintain the medication prescribed.

 The evaluation will include the following tests: medical history, St George's Respiratory
 Questionnaire, Medical Research Council (MRC), assessing the strength and endurance of
 respiratory muscle, spirometry, maximal exercise testing endurance test of the lower limbs,
 the Six Minute Walk Test and plethysmography of inductance.

 Assessment of respiratory muscle strength The assessment of respiratory muscle strength will
 consist of measures of maximal inspiratory pressure (MIP) and maximal expiratory pressure
 (MEP), performed according to Black and Hyatt (1969). The measures will be carried out using
 a manometer scaled in cmH2O (Ger-Ar) fitted with an adapter nozzle, which contains a hole two
 millimeters in diameter to eliminate the pressures of facial muscles. The subjects carry out
 the measures in standing posture using a nose clip. The MIP will be measured by a maximal
 inspiration, preceded by a maximal expiration starting from residual volume, and MEP will be
 measured by a maximal expiration, preceded by a maximal inspiration based on the total lung
 capacity. The inspiratory and expiratory must be maintained for at least one second. Will be
 performed at least three and maximum five measures will be considered acceptable if there is
 a difference of 10% or less between them. The highest value will be used for statistical
 analysis. The patients will be allowed a one-minute rest between measurements.

 Assessment of respiratory muscle endurance Incremental and constant tests After measurements
 of MIP the endurance of the inspiratory muscles using the PowerBreathe® will be evaluate.

 The test starts with incremental 10cmH2O (which is the minimum load of the unit) and every
 two minutes there will be an increase 10cmH2O, and conducted a further minute before
 increasing the load. The biggest load you can sustain for at least one minute is the maximum
 that will be considered. The test will be held constant at 80% of the pressure in the
 incremental test, to determine the time limit for implementation, considering 30 minutes as
 the maximum time (FIZ et al., 1998; RAMIREZ-SARMIENTO et al., 2002).

 In both tests the breathing pattern will be free and the breathing frequency will be noted.
 Besides the pressure generated will be monitored by a manometer attached to PowerBreathe® .

 Six Minute Walk Test (6MWT) 6MWT will be performed on a track 30 meters long and 1.5 wide,
 with markings every 2 feet. Tests will be conducted in accordance with the standards of the
 ATS (2002). Every two minutes will be checked the oxygen saturation (SpO2), heart rate (HR),
 the sensation of dyspnea and fatigue of the lower limbs by Borg CR10 scale. These measures
 associated with the measurement of blood pressure (BP) will be checked before, immediately
 after the test and after six minutes. It will be two tests on the same day, at intervals of
 30 minutes, to avoid the effect of learning on test performance. It will be considered the
 greatest distance for statistical analysis.

 Maximum Exercise Testing To perform this test will be followed by the Standardization of
 techniques and equipment for exams exercise testing and spirometry (2003), and will be
 conducted in a room properly heated, keeping the temperature around 18 ° C and 22 ° C and
 relative humidity air between 50% and 70%.

 It will be performed by a cardiologist on a treadmill using modified Bruce protocol, which is
 a good option for those patients with low functional capacity, such as the elderly and people
 with respiratory and cardiovascular disease. This is a protocol in which both the speed and
 the incline of the treadmill are increased every three minutes and modified. The two earlier
 stages have lower velocities and inclination (SAMORA e VERSIANI, 2008; NEDER e NERY, 2003).

 In addition, to monitoring the continuous ECG tracing at rest and at each stage are checked
 the values of SpO2, dyspnea and fatigue of the lower limbs by Borg CR10 scale and BP.

 The criteria for interrupting the test are: elevated blood pressure (DBP) to 120 mmHg,
 sustained drop in systolic blood pressure (SBP), marked elevation of SBP 260mmHg up, reaching
 the maximum HR (HRmax) provided by age, fall in SpO2 below 80%, ECG abnormalities, the
 patient's request due to physical exhaustion, dyspnea disproportionate to the exercise
 intensity, pain in lower limbs, dizziness or chest discomfort; failure of monitoring systems
 and / or record.

 Test of endurance of the lower limbs This test will be conducted on a treadmill for up to 30
 minutes at an intensity of 80% of the speed and slope obtained at maximal exercise testing.

 Inductance plethysmography For this test it will use a system of respiratory inductive
 plethysmography (LifeShirt; Vivo Metrics; Ventura, CA), whose sensors are two electrical
 conductors sewn to a sleeveless vest, and stay in the region of the nipples and the umbilical
 region. There are three electrodes placed in predetermined areas and connected for a
 portable, battery, which records the SpO2, electrocardiogram (ECG) and body movements in
 three axes (CLARENBACH et al., 2005).

 This is a highly reliable instrument used to monitor the volume and time components of
 breathing pattern and thoracoabdominal configuration. It is based on changes in
 cross-sectional area that occur in the compartments of the chest and abdomen. The method is
 minimally invasive, requires no mouthpiece or nose clip (except for calibration), and there
 is therefore need for direct contact with air. The accuracy of plethysmography to provide
 tidal volume values is satisfactory and depends on an initial calibration and proper
 maintenance of the same body position. The equipment will be calibrated in advance the
 measures according to the instructions of the device in all subjects. In this study, the
 following variables will be analyzed by plethysmography, tidal volume (Vt), respiratory rate
 (RR), minute ventilation (VE), the ratio between time to reach peak inspiratory flow and
 inspiratory time (PIFT / Ti), flow mean inspiratory (Vt/Ti), percent rib cage contribution to
 tidal volume (%RC/Vt) and phase angle (PhAng) (CLARENBACH et al., 2005; PARREIRA et al,
 2005).

 These measures will be carried out at 90 degrees sitting and standing, resting and doing
 exercises with their arms, and walking, to see whether dyssynchrony occurs. The signal
 acquisition will total duration of 30 minutes.

 Perception of dyspnea assessed by different scales and questionnaires. It will perform a set
 of ADL tasks (making bed, taking shower, putting on clothes, brushing teeth and combing hair,
 lifting containers on a shelf at eye level and lifting and lowering containers on a shelf
 above the scapular waist) patients will evaluate by Borg scale for dyspnea and a portable
 system will be used to assess ventilator parameters, oxygen consumption, carbon dioxide
 production and heart rate during standardized: wake up and making bed, taking shower and
 washing one's back, putting on clothes, brushing teeth and combing hair, lifting and lowering
 containers on a shelf at eye level, lifting and lowering containers on a shelf above the
 scapular waist and hanging. No specific amount of time is stipulated; the patient is only
 instructed to complete the task. During the set of ADL a metabolic system (MedGraphics VO2000
 St. Paul MN, USA) is used. In addition, these patients will self-report the MRC, LCADL scale
 and PFSDQ-M, before the start of the protocol to investigate the difference and the
 correlation between these instruments.

 Training Program After testing and pre-experimental tests, subjects will be randomly divided
 into two groups. The treatment program will consist of sessions with duration of about 1 hour
 or 1 hour and 30 minutes depending on the training, three times per week on alternate days
 for 16 consecutive weeks, totaling 48 sessions.

 Before the beginning and end of the sessions will be verified measures of blood pressure
 (BP), SpO2, HR. Measures of HR, SpO2 and BP will be obtained during the session for
 monitoring.

 All patients will undergo a general physical training. In this training will be conducted
 stretches of upper and lower limbs, treadmill exercise with HR between 70-80% HR max obtained
 at maximum exercise test, which could be carried out continuously or with intervals, up to a
 maximum of 30 minutes, and resistance exercises to LL, using free weights, with progressive
 increases of ½ kg each month to reach 2 kg in the last month.

 A group will be associated with inspiratory muscle training (GTMI). The inspiratory muscle
 strength training will be done in the POWERbreathe ®, and the patient will breathe for two
 minutes, seven times with one minute rest between them, with 15% MIP, the first week, then,
 increased 5-10% to reach 60% of the initial MIP after four weeks. After the first month,
 every fifteen days the charge will be adjusted to 60% of the new value of MIP. The breathing
 pattern will remain free, but the patient will be instructed to release all the air, not to
 hyperventilate (HILL et al, 2007).

 In other group of patients will be associated a specific exercise program for mobility and
 biomechanics of the rib cage, called respiratory exercise group (GCR), as exercises of the
 trunk and upper limbs, and stretching of large muscle groups of the trunk.

 Upon completion of the protocol will all be assessed.
Inclusion Criteria:

 -  the patients with clinical diagnosis of COPD presenting FEV1/FVC < 70% and FEV1 < 80%
 predicted by pulmonary function observed and were classified as patients with moderate
 to very severe obstruction (RABE et al., 2008),

 -  clinically stable with no history infection or exacerbation of the respiratory
 symptoms or

 -  a change in medication for two months preceding the study.

 -  the patients were non oxygen dependent, smokers or former smokers.

 Exclusion Criteria:

 -  patients with clinical diagnosis of COPD presenting FEV1/FVC ≥ 70% FEV1 ≥ 80%
 predicted (RABE et al., 2008)

 -  who present respiratory, cardiac, rheumatic, musculoskeletal, orthopedic and
 neuromuscular disorders associated that may prevent them of the testing and
 intervention proposed,

 -  that are experiencing swelling in lower limbs,

 -  that change the type of medication during the study,

 -  uncontrolled hypertension patients,

 -  saturation below 90% at rest and

 -  did not agree to sign the formal consent form proposed.