Characteristics of Abdominal Fluid in Patients With Diverticulitis Hinchey III or IV
Characteristics of Abdominal Fluid in Patients With Diverticulitis Hinchey III or IV
Perforated diverticulitis of the colon can be complicated by peritonitis, either purulent or
 fecal. Both are life threatening conditions requiring emergency surgery. The background in
 terms of reasons for inflammation (diverticulitis) and perforation to develop is unknown. In
 this study we focus on specific changes associated with inflammation, both in tissues and of
 fecal and mucosal microbiota.
A prospective study of abdominal fluid, periferal blood, tissues as well as feces in Patients
 (perforated diverticulitis with peritonitis undergoing emergency surgery, Group I), and in
 Controls (patients operated due to colorectal cancer, Group II; patients with mild
 diverticulitis not needing surgery, Group III).

 Immune acitvity in abdominal fluid and periferal blood by immunoassay of 92 individual
 proteins. mRNA expression of 96 specific genes in tissue samples. Quatification of bacterial
 diversity in feces and colon mucosa.
Inclusion Criteria:

 -  Signs of perforated diverticulitis with peritonitis and decision to perform emergency
 surgery (Group I)

 -  Signs of acute diverticulitis and no decision of emergency surgery (Group II)

 -  Patients with colorectal cancer planned for elective surgery (Group III)

 Exclusion Criteria:

 -  No surgery performed (Group I and III)

 -  Withdrawn consent (any group)