Angiotensin-Converting Enzyme Polymorphism and Acute Renal Failure (ECAREA)
Angiotensin-Converting Enzyme Polymorphism and Acute Renal Failure (ECAREA)
Associations between angiotensin-converting enzyme gene polymorphism and occurrence and
 outcome of ARDS, and with respiratory complications post cardiopulmonary bypass have already
 been demonstrated. Based on physiological effects of angiotensin II, we hypothesized that the
 I allele of the angiotensin-converting enzyme Insertion/Deletion polymorphism may be
 associated with a higher risk of acute renal failure in critically ill patients.
Associations between angiotensin-converting enzyme gene polymorphism and occurrence and
 outcome of ARDS, and with respiratory complications post cardiopulmonary bypass have already
 been demonstrated. Based on physiological effects of angiotensin II, we hypothesized that the
 I allele of the angiotensin-converting enzyme Insertion/Deletion polymorphism may be
 associated with a higher risk of acute renal failure in critically ill patients.
Inclusion Criteria:

 -  Age > 18 yrs

 -  ICU stay > 48 hours

 Exclusion Criteria:

 -  Age < 18 yrs

 -  Creatinine > 180 µmol/L

 -  Absence of consent