Predictors of Drug Hypersensitivity in HIV Infected Subjects
Predictors of Drug Hypersensitivity in HIV Infected Subjects
A case-control study to look at hypersensitive and tolerant individuals matched for HLA
 genetic predisposition, when considering predictors of drug hypersensitivity.The study aims
 to identify the immunological factors increasing the risk of drug reactions in HIV positive
 individuals.
1. To determine in a case control study clinical parameters associated with drug HSR to
 abacavir, nevirapine and efavirenz in HIV infected subjects.

 2. To measure functional and numerical differences in DC populations and responses to TLR
 ligands in patients with HSR and tolerant subjects sharing genetic markers for
 susceptibility to HSR.

 3. Identify the role of different DC populations in the development of abacavir reaction by
 mixing and depletion studies in sensitized subjects and in in vitro assays for abacavir
 hypersensitivity.

 4. To measure T cell parameters including T cell viability in culture, and expression of
 fas and fasL on blood mononuclear cells in HIV infected controls and HSR patients.

 5. To measure blood T cell populations including drug reactive T cells and T regulatory
 cells in tolerant and reactive subjects with genetic susceptibility to Abacavir and
 Nevirapine HSR.
Inclusion Criteria:

 -  HIV infected patients on treatment with the drugs Efavirenz, Nevirapine, or Abacavir.

 -  Age over 18 Cases are those who have had a hypersensitivity reaction, and controls are
 those who have had no reaction