Deep Brain Stimulation in Patients With LUTS
Deep Brain Stimulation in Patients With LUTS
Deep brain stimulation (DBS) is a neurosurgical procedure using a device that improves motor
 symptoms of specific neurological and movement disorders such as Parkinson's disease or
 Essential Tremor. As part of the patient's care, the DBS is implanted when symptoms cannot be
 satisfactorily controlled with medications or conventional therapies. Lower urinary tract
 symptoms are common in patients who have underlying neurological or movement disorders and
 control over lower urinary tract function is poorly understood. In this study investigators
 are evaluating the effects of DBS on lower urinary tract function.
Deep brain stimulation (DBS) is a neurosurgical procedure that improves motor symptoms of
 specific neurological and movement disorders such as Parkinson's disease or Essential Tremor.
 DBS is implanted when symptoms cannot be satisfactorily controlled with medications or
 conventional therapies. After insertion of deep electrodes, electrical stimulation will be
 delivered to modulate specific neurons in certain areas of the brain. Despite, the known
 motor effects for DBS, its nonmotor effects on other organs such as the urinary tract and
 bladder function remains unclear. Lower urinary tract symptoms such as frequency, urgency,
 urinary incontinence, or incomplete bladder emptying are common in patients who have
 underlying neurological or movement disorders. In addition, central neural control over lower
 urinary tract function is still poorly understand. In this trial investigators plan to
 evaluate the effects of Deep Brain Stimulators (DBS) on lower urinary tract function. This
 trial is designed to test the hypothesis that DBS improves objective and subjective symptoms
 of lower urinary tract function in specific patient populations. The investigators plan to
 test this hypothesis by using validated patient reported outcome questionnaires and
 urodynamic testing (both are part of routine care for neurogenic bladder) before and after
 DBS implantation. In addition, this trial will shed some light in understanding higher neural
 control of bladder and potentially identify target areas for future intervention.
Inclusion Criteria:

 -  Patients who are a candidate for Deep Brain Stimulation (DBS) as standard care for
 neurologic symptoms and have a moderate or greater urinary bother American Urological
 Association Symptom Score (AUASS≥8)

 Exclusion Criteria:

 -  Pregnant, breastfeeding mothers and all individuals younger than 18 years of age will
 be excluded. Patients with history of urinary diversion or augmentation cystoplasty
 will also be excluded.