A Study To Observe Safety And Blood Concentrations Of PF-04995274 During And Following the Administration of Multiple Doses Of PF-04995274 In Healthy Adult And Healthy Elderly Volunteers.
A Study To Observe Safety And Blood Concentrations Of PF-04995274 During And Following the Administration of Multiple Doses Of PF-04995274 In Healthy Adult And Healthy Elderly Volunteers.
This study is designed to observe the safety and blood concentrations of PF-04995274 during
 and following the administration of multiple doses of PF-04995274 for a duration of 14 days,
 in healthy adult and healthy elderly.
To examine the safety and pharmacokinetics of PF-04995274 in healthy adult and healthy
 elderly subjects after multiple doses.
Inclusion Criteria:

 -  For Healthy adult volunteers: healthy male and/or female subjects of non child bearing
 potential between the ages of 18 and 55 years, inclusive. (Healthy is defined as no
 clinically relevant abnormalities identified by a detailed medical history, full
 physical examination, including blood pressure and heart rate measurement, 12 lead ECG
 and clinical laboratory tests.)

 -  For Healthy Elderly volunteers: healthy male and/or female subjects of non child
 bearing potential between the ages of 65 and 85 years, inclusive. Subjects must be in
 reasonably good health as determined by the investigator based on a detailed medical
 history, full physical examination (including blood pressure and pulse rate
 measurement), 12 lead ECG and clinical laboratory tests. Subjects with mild, chronic,
 stable disease (eg, controlled hypertension, non-insulin dependent diabetes,
 osteoarthritis) may be enrolled if deemed medically prudent by the investigator. In
 order to ensure an age range relevant to the Alzheimer's Disease (AD) population, no
 more than 30% of subjects enrolled in any cohort may be less than 70 years of age.

 Exclusion Criteria:

 -  Evidence or history of clinically significant hematological, renal, endocrine,
 pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or
 allergic disease (including drug allergies, but excluding untreated, asymptomatic,
 seasonal allergies at time of dosing).