Motor-Sparing Peripheral Nerve Blockade Facilitates Mobility Post Total Knee Arthroplasty: A Randomized Controlled Trial
Motor-Sparing Peripheral Nerve Blockade Facilitates Mobility Post Total Knee Arthroplasty: A Randomized Controlled Trial
The primary aim of this pilot study will be to develop a clinically meaningful,
 patient-centric, and pragmatic protocol to evaluate the comparative effectiveness of
 different strategies for achievement of the ideal balance between analgesia and functional
 mobility following total knee arthroplasty (TKA).
Pain management for total knee replacement (TKR) patients has evolved rapidly over the
 previous decade. The most recent advances in anesthesia include peripheral nerve blockade,
 which offers the promise of earlier postoperative mobilization in addition to effective pain
 relief. The rapidity with which these advancements have been adopted seems to have outpaced
 the science to support them. The result has been the institution of countless combinations of
 perioperative pain management strategies in centers nationwide with little standardization,
 consistency, or objective evidence. The extent to which these various strategies achieve safe
 and effective perioperative pain control or functional preservation remains poorly defined.
 This prospective randomized control trial will aim to identify meaningful patient-centric
 outcome measures, differentiate from among three perioperative TKR anesthetic and analgesic
 strategies, and provide a template for interdisciplinary collaboration among orthopedic
 surgeons, anesthesiologists, physical therapists, and patients. With the knowledge gained
 further study will continue to refine the most optimal early pain control protocol.

 All primary TKR patients undergoing surgery at the Medical University of South Carolina who
 are able to receive spinal anesthesia will be randomized prior to surgery to one of three
 forms of lower limb nerve blockade: 1) Continuous femoral nerve catheter plus single
 injection sciatic nerve block, 2) Adductor canal catheter plus selective tibial nerve block,
 3) Adductor canal catheter alone. All patients will receive additional standardized pain
 medications as well as early mobilization with physical therapy. The primary outcome measure
 will be postoperative visual analog pain scale (VAS), with secondary measures to include
 validated patient-reported outcome measures, objective functional measures (timed-up-and-go
 (TUG), patient satisfaction scores, length of stay, discharge disposition, and complications.
 The investigators plan to enroll approximately 90 patients. This will allow us to reach our
 randomization goal of at least 75 patients while taking into account withdrawals. The 75
 patients will be randomized into the three treatment three treatment arms over a 6-month
 recruitment period, with a 3 month follow-up for patient reported outcome and satisfaction
 data. A focus group will facilitate patient engagement and provide information for generation
 of a preference survey to guide future study design.
Inclusion Criteria:

 -  Males and Females 18 years of age or older

 -  Undergoing elective primary total knee arthroplasty

 -  Patient is willing and able to give consent and participate

 Exclusion Criteria:

 -  Inability to receive spinal anesthesia or peripheral nerve block

 -  Non-ambulatory patients

 -  Non- English speaking patients

 -  Vulnerable populations including prisoners