Dextromethorphan to Treat Patients With Voice Spasms
Dextromethorphan to Treat Patients With Voice Spasms
This study will examine how dextromethorphan, a drug that alters reflexes of the larynx
 (voice box), might change voice symptoms in people with voice disorders due to uncontrolled
 laryngeal muscle spasms. These include abductor spasmodic dysphonia (breathy voice breaks),
 adductor spasmodic dysphonia (vowel breaks), muscular tension dysphonia (tight strained
 voice), and vocal tremor (tremulous voice). Dextromethorphan-one of a group of drugs called
 NMDA antagonists-has been used for years in over-the-counter cough suppressant medicines. In
 animal studies, the drug has blocked one of the reflexes in the larynx that may be associated
 with spasms in the laryngeal muscles. This study will compare the effects of
 dextromethorphan, lorazepam (a valium-type drug), and a placebo (inactive substance) in
 patients with the four types of voice disorders described above.

 Patients with spasmodic dysphonia, muscular tension dysphonia and vocal tremor may be
 eligible for this study. Individuals who smoke or use tobacco, who have vocal nodules or
 polyps, or who have a history of airway obstruction may not participate. Candidates will be
 screened with a medical history and physical examination, a questionnaire, voice recording
 (repeating sentences into a microphone), and nasolaryngoscopy (examination of the larynx with
 a tube advanced through the nose). For the nasolaryngoscopy, the inside of the nose is
 sprayed with a decongestant (to open the nasal passages) and possibly a local anesthetic. A
 small, flexible tube called a nasolaryngoscope is passed through the nose to look at the
 larynx during speech and other tasks, such as singing, whistling and prolonged vowels.

 Participants will be admitted to the NIH Clinical Center for each of three visits, which will
 last from the afternoon of one day to late afternoon of the following day. At each visit,
 patients will complete a questionnaire, baseline speech recording, and a test for sedation
 level. They will take three pills-either dextromethorphan, lorazepam, or placebo-one every 6
 hours. Vital signs will be checked every 6 hours and the level of sedation during waking
 hours will be monitored. One to three hours after taking the third pill, speech recording,
 questionnaire and test of sedation will be repeated to check for possible voice changes.
 Patients will be given a different pill at each visit.

 ...
Studies of spasmodic dysphonia (SD) have increasingly pointed to the possibility of a central
 sensori-motor control disorder. Sensori-motor processing has been found abnormal in both
 adductor and abductor spasmodic dysphonia based on reflex conditioning studies. These studies
 demonstrated an increased frequency of R2 muscle responses during rapid paired presentation
 of electrical stimuli to the superior laryngeal nerve in spasmodic dysphonia. Thus,
 uncontrolled R2 responses were hypothesized to be the basis for the uncontrolled muscle
 bursts in these patients. Selective suppression of late R2 laryngeal adductor responses by
 N-methyl-D-Aspartate (NMDA) blockade in cats was demonstrated by Ambalavanar et.al. In
 particular, dextromethorphan reduced the frequency of R2 responses from 95% to 25% (P =
 0.015). Dextromethorphan is a widely used antitussive agent that has been in use for over 30
 years. In a double-blind randomized crossover design, 3 groups of patients will receive be
 randomly assigned to one of 6 order cohorts. They will then receive either dextromethorphan
 at a 8 mg/kg/d dose divided in a Q6 hour dosing schedule with only 3 doses administered PO
 every 6 hours for 3 dosages, 04 mg/kg/d of lorazepam PO every 6 hours for 3 dosages or a
 placebo administrated in the same way during Phase A. After a minimum of a 1-week washout
 interval, the patients will be given either the other medication or placebo during Phase B
 and then the remaining medication or placebo during Phase C.

 Our hypothesis is that dextromethorphan, an NMDA receptor blocker, will reduce voice breaks
 in spasmodic dysphonia to a greater degree than lorazepam, which has similar sedating side
 effects, but does not affect NMDA receptors with a different mechanism. On the other hand,
 patients with other idiopathic voice disorders, muscular tension dysphonia and vocal tremor,
 are hypothesized not to have a similar benefit from dextromethorphan. During the double-blind
 randomized cross-over study, three groups will be included, 10 patients with adductor or
 abductor spasmodic dysphonia, 10 with muscular tension dysphonia and 10 with vocal tremor.
 The results will determine if dextromethorphan has potential as a treatment option for
 patients with adductor or abductor SD.
-  INCLUSION CRITERIA:

 Patients with Spasmodic Dysphonia will meet the following criteria:

 1. No structural abnormalities affecting the larynx such as vocal fold nodules, polyps,
 carcinoma, cysts, contact ulcers, inflammation (laryngitis).

 2. Symptoms of adductor or abductor spasmodic dysphonia present during speech and not
 apparent at rest,

 3. Symptoms of adductor or abductor spasmodic dysphonia less evident during whisper,
 singing or falsetto.

 4. Symptoms of adductor or abductor spasmodic dysphonia become worse with prolonged
 speaking, practice or anxiety.

 5. Reflexive and emotional aspects of voice function are unaffected, such as coughing and
 laughter or crying.

 Patients with Muscular Tension Dysphonia will meet the following criteria:

 1. Increased phonatory muscle tension in the paralaryngeal and suprahyoid muscles on
 palpation,

 2. Constant elevation of the larynx in the neck during speech.

 3. A consistent hypertonic laryngeal posture for phonation, either an open posterior
 glottic chink between the arytenoid cartilages on phonation, an anterior-posterior
 squeeze (pin hole posture) or ventricular hyperadduction.

 4. A normally appearing larynx.

 Patients with vocal tremor will have tremor isolated to the larynx without noticeable
 tremor of the head and pharynx. Tremor of the vocal folds should be evident during a
 prolonged vowel and also noticeable in the larynx during connected speech containing
 vowels.

 EXCLUSION CRITERIA:

 Subjects in all three groups will be without:

 1. Cardiac, pulmonary, neurological, psychiatric or speech and hearing problems as
 determined by medical history and examination by a physician and an EKG. Any patient
 with a history of airway obstruction will be excluded from the study.

 2. Reduction in the range of vocal fold movement during non-speech tasks such as
 whistling suggesting either paralysis or paresis, joint abnormality or neoplasm.

 3. No smokers or tobacco users will be included in the study.

 4. Exclude mucosal changes such as vocal nodules or polyps.

 5. Subjects with a history of a psychiatric disorder, under the care of a psychiatrist,
 or on medications for treatment of a psychiatric disorder will be excluded from study.
 Examples of psychiatric disorders to be excluded are: somatoform disorders, conversion
 disorders, currently under treatment for a major depression, or a history of
 schizophrenia or a bipolar disorder. However, a history of a previous episode of a
 minor reactive depression would not exclude a person from participation.

 6. Subjects taking carbonic anhydrase inhibitors, cimetidine, hydrochlorthiazide,
 nicotine, quinidine, ranitidine, sodium or calcium bicarbonate and triamterene must
 either discontinue these medications or be excluded from study.

 7. Subjects with grade 2 or higher hepatic or renal dysfunction will be excluded from
 study.

 8. Pregnant women will be excluded from the study as it is not known if the study drugs
 are harmful to the fetus. If a woman becomes pregnant during the study, she will be
 removed.