Satisfaction & Efficacy of Compression Using Surgical Gloves in Chemo-induced Peripheral Neuropathies
Satisfaction & Efficacy of Compression Using Surgical Gloves in Chemo-induced Peripheral Neuropathies
Evaluation of Satisfaction & Efficacy of Compression Using Surgical Gloves in Peripheral
 Neuropathies Due to Chemotherapy
Peripheral neuropathy (PN) is an adverse event of numerous chemotherapy agents commonly used,
 including taxanes (paclitaxel, docetaxel) and platinum-based treatments (oxaliplatine,
 cisplatine, carboplatine).

 Taxanes are widely used in breast cancer. Docetaxel and paclitaxel became indispensable
 during the last decade in metastatic and early stage breast cancer treatment. For
 platinum-based chemotherapies, oxaliplatine is one of the main molecules used in digestive
 oncology, particularly in colorectal cancer.

 The limiting toxicities of taxanes and platinum-based treatments which can lead to the
 therapeutic scheme modification (therefore to a potential diminution of efficacy and
 eventually to treatment stop) are mainly hematologic (neutropenia) and neurological, the most
 frequent neuro-toxicity event being a PN associated or not to neuropathic pains. The PN
 induced by chemotherapy can occur prematurely during the treatment course, persist between
 the treatments' cycles and last a long time after the end of cycles, with an impact on
 patients' quality of life. Symptoms are mainly sensitive, including pain, paresthesia and
 hands / foot numbness. These symptoms, as the hematologic toxicity, represent a major
 limiting factor for the treatment.

 According to the ASCO recommendations, there is no effective prophylactic method against the
 chemo-induced PN. In a retrospective study, the chilled gloves used for preventing the nail
 lesions during chemotherapy may reduce the incidence of docetaxel-induced PN. Recently, the
 surgical gloves efficacy against paclitaxel-induced PN has been evaluated prospectively in
 women presenting a metastatic or early stage breast cancer, with a percentage of grade >=2 NP
 significantly lower for the hand protected by surgical gloves than the control hand without
 glove (compression-induced vasoconstriction responsible for a blood flow reduction in the
 hands and therefore for the local exposure to chemotherapy agents) and a good tolerance.

 Chilled gloves, which use the same principle of vasoconstriction through cold, are also used
 in the current practice for preventing the PN occurrence. However, contrary to surgical
 gloves, they can be not well tolerated since the very first cycles (intolerance to cold
 sensation).

 The objective of this study is to evaluate the medium and long term efficacy of compression
 induced by surgical gloves against the PN development in two frequent indications in
 oncology, patients treated with paclitaxel (breast cancer) or oxaliplatine (colorectal
 cancer) and patients' satisfaction.
Inclusion Criteria:

 -  Age >= 18 years old

 -  Breast cancer requiring a treatment by paclitaxel or colorectal cancer requiring a
 treatment by oxaliplatine

 -  At least 8 chemotherapy cycles planned

 -  Able to understand, read and write French language

 -  Covered by a social insurance

 -  Dated and signed informed consent

 Exclusion Criteria:

 -  Pre-existing neuropathy or history of neuropathy

 -  Psychological, family, sociological or georgraphical condition that may potentially
 compromise the adherence to study protocol and follow up

 -  Cohort 1: Patients presenting a Raynaud's syndrome (contra-indication to cold
 temperatures)

 -  Participation to clinical trial which may interfere with the evaluation of the main
 endpoints.

 -  Pregnant or breastfeeding women