Genetic Expression Alteration Affect on Lateral Neck Node Metastasis of Thyroid Papillary Microcarcinoma : Microarray Analysis
Genetic Expression Alteration Affect on Lateral Neck Node Metastasis of Thyroid Papillary Microcarcinoma : Microarray Analysis
In this study, the investigators look at the genetic expressional alteration which influenced
 on the early lateral neck node metastasis in thyroid papillary microcarcinoma.
Papillary thyroid carcinomas (PTCs) measuring 1.0 cm or less in diameter were defined as
 papillary thyroid microcarcinomas (PTMCs) by the World Health Organization (WHO), emphasizing
 on their benign behavior, probably of little clinical significance, which do not affect
 patients' survival. However, some reported that PTMCs may have aggressive behavior, can cause
 locoregional recurrences, cervical lymph node metastases, and even distant metastases. But
 till now, the characteristics of PTMCs with early lateral neck node metastasis were only
 reviewed and described by the clinicopathological parameters, and no analysis of PTMCs by the
 gene level is available. In these study, we investigate the genetic expressional alteration
 which influenced on the early lateral neck node metastasis in thyroid papillary
 microcarcinoma.
Inclusion Criteria:

 -  age≥20 years old

 -  Conventional type papillary thyroid microcarcinoma (0.5cm≤tumor size≤1.0cm)

 -  group 1: no lymph node metastasis /group 2: with lateral neck node metastasis

 Exclusion Criteria:

 -  tumor with capsular invasion (T3 tumor)

 -  distant metastasis

 -  combined underlying thyroiditis