Polycystic Ovary Syndrome (PCOS) - Effect Of Physical Exercise And Electroacupuncture
Polycystic Ovary Syndrome (PCOS) - Effect Of Physical Exercise And Electroacupuncture
Hypothesis:

 The overall hypothesis is that women with PCOS, both obese and non-obese, have larger
 adipocytes, altered metabolism and signs of inflammation in adipose tissue and that these
 changes are associated with high sympathetic nerve activity, hyperandrogenism
 hyperinsulinaemia, insulin resistance with progression to type II diabetes and cardiovascular
 disease (CVD) as well as psychological distress and reduced quality of life. Physical
 exercise and electro-acupuncture decrease high concentrations of androgens, induce regulare
 menstrual pattern, inhibits high sympathetic activity and restore the PCOS induced
 disturbances.
Primary outcome: Changes in androgen concentrations and menstrual pattern

 Secondary outcome: changes in sympathetic nerve activity, uterus peristalsis, ovarian
 morphology, adipose tissue related variables, insulin sensitivity, coagulation factors and
 health related quality of life and symptoms of anxiety and depression.
Inclusion Criteria:

 -  To get the diagnosis polycystic ovary syndrome (PCOS), ultrasonography should reveal
 at least 1 ovary with PCO according to the Rotterdam diagnostic criteria as well as
 one of the following two symptoms:

 1. Anovulation/oligoovulation defined as ≥ 35 days during the last year

 2. Clinical signs of hyperandrogenism (hirsutism, acne)

 Exclusion Criteria:

 -  Cardiovascular disease

 -  Diabetes mellitus

 -  Other endocrine disease (congenital adrenal hyperplasia, androgen producing tumour,
 Cushing's syndrome)

 -  Estrogen/gestagen treatment during the last 3 months

 -  Breast-feeding the last 6 months

 -  Antiandrogen treatment the last 3 months