Determinants of Onset and Progression of COPD in Young Adults
Determinants of Onset and Progression of COPD in Young Adults
COPD (Chronic Obstructive Pulmonary Disease) is a Public Health problem due to its impact in
 the patient's quality of life, high prevalence, growing incidence and socioeconomic
 implication. COPD natural history and first stages determinants are unknown. Knowing them
 will help to understand the natural history of the disease and to design interventions that
 can modify the prognosis of the disease.

 Study objectives: (1) To characterize an early COPD population from a multidimensional point
 of view including demographic, social, family and clinical data, lung function, exercise
 capacity, image, microbiology, quality of life, exacerbations, comorbidities and blood and
 sputum biomarkers. (2) To compare this patients with smoking subjects, with normal lung
 function, matched by age, sex and site. (3) To create an early COPD cohort to be followed in
 the future to understand the complete natural history of the disease.

 Methods: Design: multicenter cross-sectional study that will allow establishing a
 well-characterized cohort of early COPD patients for later follow-up. Recruitment will be
 done in Primary Care settings. Subjects: smokers (> 10 packs year) between 35-50 years old
 with a spirometry (normal or obstructive) done in the last year. Diagnosis of COPD will be
 based on the smoking history and a postbronchodilator test FEV1(Forced Expiratory Volume in
 the first second) / FVC(Forced Vital Capacity) < 70%. Age, sex and site matched 'healthy'
 smoker controls will be compared with the COPD cases. Variables that will be collected in the
 reference hospitals are: health questionnaires, lung function test, exercise capacity, blood
 and sputum samples, and low dose CT-scan. Statistical analysis: early COPD patient's
 characteristics will be described and then, will be compared, with control subjects through a
 conditional multiple logistic regression analysis.
**Inclusion Criteria:

 COPD case:

 -  Subjects between 35 and 50 years

 -  Post-bronchodilator spirometry with FEV1/FVC <70%

 -  Smoker or ex-smoker with total cumulative exposure > 10 pack-years

 Smoking control:

 -  Subjects between 35 and 50 years

 -  Post-bronchodilator spirometry with FEV1/FVC >=70%

 -  Smoker or ex-smoker with total cumulative exposure> 10 pack-years

 -  Exclusion Criteria:

 For cases:

 -  Chronic inflammatory diseases including autoimmune diseases under treatment.

 -  HIV

 -  Active cancer

 -  Cystic or saccular bronchiectasis

 -  Conditions that may interfere with follow-up: frequent change of residence,
 psychiatric disorders, dementia…

 For controls:

 -  Chronic inflammatory diseases including autoimmune diseases under treatment

 -  HIV

 -  Active cancer

 -  Chronic respiratory diseases:

 -  active tuberculosis

 -  interstitial lung diseases

 -  cystic or saccular bronchiectasis

 -  ever diagnosed asthma

 -  deficit of alpha1-antitrypsin

 -  Conditions that may interfere with follow-up: frequent change of residence,
 psychiatric disorders, dementia …