Investigation and Study on the Status of Endovascular Therapy in Acute Ischemic Stroke Ischemic Stroke
Investigation and Study on the Status of Endovascular Therapy in Acute Ischemic Stroke Ischemic Stroke
This study aims to build a database for patients with acute ischemic stroke who receive
 endovascular therapy and analyze the current situation, effectiveness, safety and
 cost-effectiveness of endovascular therapy for acute ischemic stroke in China.
Study design is a registry, prospective, multicenter study of acute ischemic stroke patients
 with endovascular treatment. A database will be established including age, gender, smoking
 history, blood pressure, blood glucose, previous history (such as coronary heart disease,
 atrial fibrillation, hypertension, diabetes, stroke history, etc.), history of antiplatelet
 drugs, onset to treatment time, National Institute of Health Stroke Scale (NIHSS) score
 before treatment.

 Indications for endovascular therapy refer to the current guidelines. All patients will
 receive endovascular therapy, including direct endovascular therapy or intravenous
 thrombolysis with endovascular therapy. The effectiveness, safety and cost-effectiveness of
 endovascular therapy for acute ischemic stroke will be analyzed.

 This study will enroll up at least 1,000 patients in 70 centers in China. The primary end
 point are proportion of patients with good prognosis after 90 days and intracranial
 hemorrhage transformation type after 24 hours.
Inclusion Criteria:

 1. Clinical signs and symptoms consistent with the diagnosis of an acute ischemic stroke

 2. Age ≥18 years

 3. NIHSS ≥ 6

 4. ICA or MCA-M1 or MCA-M2 occlusion as evidenced by MRA or 4D-CTA

 5. Ethrombectomy can be initiated (femoral puncture) within 6 hours after onset or
 between 6 and 24 hours after time last know well if conform to the imaging inclusion
 criteria: Target Mismatch Profile on CT perfusion or MR perfusion: ischemic core
 volume is ≤ 70 ml, mismatch ratio is ≥ 1.8, penumbra volume is ≥ 15 ml.

 Exclusion Criteria:

 1. Large area cerebral infarction of anterior circulation on early CT image (more than
 1/3 of cerebral hemisphere)

 2. Blood glucose <2.7mmol/L or >22.2mmol/L

 3. Other serious, advanced, or terminal illness (investigator judgment) or life
 expectancy is less than 90 days

 4. Pregnant