Evaluation of Post Hospital Administration of Celecoxib Following Minimally Invasive Knee Replacement Surgery
Evaluation of Post Hospital Administration of Celecoxib Following Minimally Invasive Knee Replacement Surgery
This study will evaluate the benefits of continuing celecoxib through six weeks of total knee
 arthroplasty recovery. This is a randomized, double blind study with a group of approximately
 130 primary total knee patients. All patients will receive celecoxib throughout their
 hospitalization as per current minimally invasive total knee arthroplasty protocol. At the
 time of hospital discharge, participating patients will be randomly placed on either
 celecoxib 200mg twice a day or a placebo twice a day.

 This study will determine if the continued use of celecoxib for six weeks after total knee
 arthroplasty hospitalization will further decrease narcotic consumption, improve knee range
 of motion, improve ambulatory ability, and improve patient satisfaction over patients
 receiving celecoxib only during the acute hospitalization.
Inclusion Criteria:

 -  having undergone a minimally invasive total knee by select surgeon

 -  voluntarily enrolled

 -  independent community ambulators

 -  only patients being discharged directly home

 Exclusion Criteria:

 -  celecoxib allergy or intolerence

 -  Renal insufficiency (defined as serum creatine level >1.5 mg/dL or BUN level >22mg/dL

 -  History of bleeding gastic or duodenal ulceration

 -  New York Heart Association Class III or IV Congestive Heart Failure

 -  Previous myocardial infarction or cerebralvascular event

 -  Severe inflammatory bowel disease

 -  Known coagulation abnormality or hepatic disease

 -  Chronic coumadin administration

 -  Refusal by primary or cardiac physician