The Functional Magnetic Resonance Imaging Study on the Processing of Acute Pain and Cognition Among Perimenopause Women
The Functional Magnetic Resonance Imaging Study on the Processing of Acute Pain and Cognition Among Perimenopause Women
There lacks effective early screen system for the migraine-susceptible women during the
 peri-menopause period. The processing of acute pain and cognition as well as the underling
 functional magnetic resonance imaging (fMRI) features are suitable for screening
 pain-susceptible individual. However, there is no study on this issue among the large sample
 peri-menopause women. The investigators thus designed the current trial to investigate the
 processing of acute pain and cognition as well as the underling featured functional magnetic
 resonance imaging (fMRI).The investigators will combine pain behavior,cognitive task, fMRI
 analysis, psychophysiological interaction (PPI) and suitable statistical package to
 investigate the relationship between the above mentioned features and the occurrence of
 migraine and then test the efficacy of these features in predicting migraine development. The
 investigators will then try to establish the screening system for migraine-susceptible
 individuals in peri-menopause women.
Although the prevalence of migraine is very high during peri-menopause period, there exist
 significant individual differences in whether developing migraine among this population.
 However, there still lacks effective early screen system for the migraine- susceptible women
 during the peri-menopause period. Individual acute pain processing and its interaction with
 cognition as well as the underling featured functional magnetic resonance imaging (fMRI) are
 suitable for screening pain-susceptible individual. Actually, the featured acute pain
 processing and its interaction with cognition as well as fMRI alterations were reported in
 two previous small sample trials among pre-menopause population, however, there is no similar
 study on large sample peri-menopause women. The investigators previously reported abnormal
 acute pain processing and decreased cognition in the experimental peri-menopause rats as well
 as peri-menopause women with migraine. The investigators thus raised the current hypothesis
 that the acute pain processing and its interaction with cognition as well as the underling
 featured functional magnetic resonance imaging (fMRI) are usable for screening
 migraine-susceptible individuals among peri-menopause women. In the current project, The
 investigators will combine pain behavior,cognitive task, fMRI analysis, psychophysiological
 interaction (PPI) and suitable statistical package to investigated the relationship between
 the above mentioned features and the occurrence of migraine and then test the efficacy of
 these features in predicting migraine development. The investigators will then try to
 establish the screening system for migraine-susceptible individuals in peri-menopause women.
Inclusion Criteria:

 -  25 years old or above

 -  Healthy women

 Exclusion Criteria:

 -  Those with history of present illness

 -  Past history of significant neurological and psychiatric disorders or MRI
 contraindication