Radiolabeled Monoclonal Antibody in Treating Patients With Glioblastoma Multiforme or Anaplastic Astrocytoma
Radiolabeled Monoclonal Antibody in Treating Patients With Glioblastoma Multiforme or Anaplastic Astrocytoma
RATIONALE: Radiolabeled monoclonal antibodies can locate tumor cells and deliver
 tumor-killing substances to them without harming normal cells. This may be an effective
 treatment for some types of brain tumors.

 PURPOSE: Phase II trial to study the effectiveness of radiolabeled monoclonal antibody in
 treating patients who have glioblastoma multiforme or anaplastic astrocytoma.
OBJECTIVES:

 -  Determine the median time to disease progression in patients with newly diagnosed
 unresectable glioblastoma multiforme (GBM), recurrent GBM, or recurrent anaplastic
 astrocytoma treated with interstitial iodine I 131 monoclonal antibody TNT-1/B.

 -  Determine the median survival time of these patients treated with this regimen.

 -  Determine the safety of this regimen in terms of neurotoxicity, renal, hepatic,
 hematologic, and biochemical profiles in these patients.

 -  Confirm the maximum tolerated dose of this regimen in these patients.

 -  Optimize the drug delivery of this regimen in these patients.

 -  Assess the response of these patients in terms of MRI measured gadolinium enhanced tumor
 volume and gadolinium enhanced tumor area at 8 and 12 weeks following the last dose of
 study drug.

 OUTLINE: This is a multicenter study.

 Patients undergo stereotactic implantation of 2 interstitial catheters into the tumor bed.
 One day later, patients receive iodine I 131 monoclonal antibody TNT-1/B interstitially over
 approximately 24 hours. At selected centers, up to 3 additional groups of 3 patients each
 will receive study drug up to 48 hours. Catheters are removed 1 day after completion of the
 infusion. A gadolinium enhanced MRI is performed during week 8. Patients with partial
 response, minimal response, or stable disease repeat the above treatments during week 9.
 Patients with complete response, progressive disease, or unacceptable toxicity receive no
 additional treatment.

 Patients are followed every month until disease progression. All patients regardless of
 disease progression or retreatment are followed at 36 weeks.

 PROJECTED ACCRUAL: A total of 60 patients (20 patients with newly diagnosed unresectable
 glioblastoma multiforme [GBM]; 20 patients with recurrent GBM; and 20 patients with recurrent
 anaplastic astrocytoma) will be accrued for this study.
DISEASE CHARACTERISTICS:

 -  Histologically confirmed newly diagnosed unresectable glioblastoma multiforme (GBM),
 recurrent GBM, or recurrent anaplastic astrocytoma (AA)

 -  MRI scan documenting gadolinium enhanced tumor volume of at least 5 cm3, but no
 greater than 60 cm^3

 -  Recurrent GBM and AA must be documented by MRI after the most recent treatment
 and before any planned surgical debulking

 -  At least 5 days since prior surgical debulking

 -  No planned resection of newly diagnosed GBM before or during study

 -  No bilateral noncontiguous gadolinium enhancing tumors

 -  No satellite lesions greater than 1.5 cm from anticipated location of interstitial
 catheter tip

 -  No more than 2 satellite lesions

 PATIENT CHARACTERISTICS:

 Age:

 -  18 and over

 Performance status:

 -  Karnofsky 60-100%

 Life expectancy:

 -  Not specified

 Hematopoietic:

 -  Platelet count at least 100,000/mm^3

 -  Absolute neutrophil count at least 1,500/mm^3

 -  WBC at least 3,000/mm^3

 Hepatic:

 -  Hepatitis B surface antigen negative

 -  Bilirubin no greater than 2.5 times upper limit of normal (ULN)

 -  SGOT and SGPT no greater than 3 times ULN

 -  Alkaline phosphatase no greater than 3 times ULN

 -  Lactic dehydrogenase no greater than 3 times ULN

 -  Prothrombin time no greater than 1.5 times ULN

 Renal:

 -  Creatinine clearance at least 50 mL/min

 Cardiovascular:

 -  No significant unstable cardiovascular disease

 -  No New York Heart Association class III/IV heart disease

 -  No evidence of myocardial infarction within the past 3 months

 Other:

 -  Not pregnant

 -  Negative pregnancy test

 -  Fertile patients must use effective contraception

 -  Human antichimeric antibody (HACA) titer no greater than 48 ng/mL

 -  No anatomical or physiological considerations that would preclude study participation

 -  No active autoimmune disease, active infection, or traumatic injury requiring
 treatment

 -  HIV negative

 PRIOR CONCURRENT THERAPY:

 Biologic therapy:

 -  Not specified

 Chemotherapy:

 -  At least 4 weeks since prior intravenous chemotherapy or Gliadel wafers

 Endocrine therapy:

 -  Not specified

 Radiotherapy:

 -  At least 8 weeks since prior external beam or gamma knife radiotherapy

 Surgery:

 -  See Disease Characteristics

 Other:

 -  At least 30 days since prior investigational treatment