Risk Factors of Individuals With Coronary Artery Disease
Risk Factors of Individuals With Coronary Artery Disease
It would be useful to study coronary arteriovenous difference of various markers in patients
 who are undergoing coronary angiography for suspected coronary artery disease. Environmental
 and genetic factors may play a role in the progression of coronary artery disease. The goal
 of this project is to establish a series of cross-sectional / case-control studies to
 evaluate risk factors of coronary artery disease in China.
This study is designed to investigate the epidemiologic, genetic, laboratory and clinical
 characterization of individuals with coronary artery disease. The study group will consist of
 consecutive patients who are undergoing coronary angiography for suspected coronary artery
 disease. The diagnosis of coronary artery disease will be confirmed by coronary angiography
 performed with the Judkins technique using a quantitative coronary angiographic system.
 Coronary artery disease will be considered to be present if there is a diameter stenosis of
 at least 50% in at least one of the three major epicardial coronary arteries. The number of
 diseased vessels will be determined and a classification of 1-, 2-, and 3-vessel disease will
 be used. Coronary artery segments will be defined according to the Coronary Artery Surgery
 Study classification. Blood samples from vein and coronary artery will be collected. We will
 study coronary arteriovenous difference of various markers. Urinary samples will be obtained
 the day of coronary angiography. We will explore the environmental (including family history,
 life style, diet, physical activity, neuropsychological functioning，plasma levels of
 oxidative stress factors, angiogenic factors, and inflammatory markers, etc.) and genetic
 (including oxidative stress factors and inflammatory factors, etc.) risk factors. We will
 study the association between various environmental risk factors with the clinical
 characterization and correlation between the genetic polymorphisms and the presence of
 coronary artery disease.
Inclusion Criteria:

 -  This is a study only of Chinese.

 -  Subjects will be allowed to participate if they self-identify as Chinese.

 -  The age range of the participants will be between 18 and 89 years.

 -  The study group will consist of consecutive patients who are undergoing coronary
 angiography for suspected coronary artery disease.

 Exclusion Criteria: