Treatment of Mild to Moderate Joint Pain in Patients With Chronic Plaque Psoriasis Receiving Efalizumab
Treatment of Mild to Moderate Joint Pain in Patients With Chronic Plaque Psoriasis Receiving Efalizumab
The purpose of this study is to evaluate tolerability and effectiveness of conventional
 treatment for mild to moderate arthritic or arthralgic symptoms while subjects are being
 treated with efalizumab for psoriasis.
The study objective is to demonstrate that mild to moderate arthritis or arthralgia may be
 controlled using conventional therapy while being treated with efalizumab, without loss of
 efficacy.
Inclusion Criteria:

 -  Females cannot become pregnant while participating in study.

 -  Have a history of plaque psoriasis for at least 6 months.

 -  Receiving or about to receive efalizumab for the treatment of chronic plaque
 psoriasis.

 -  Have mild to moderate arthritis or arthralgia occurring while on treatment with
 efalizumab or untreated mild to moderate arthritis or arthralgia present at the time
 of initiating treatment with efalizumab.

 Exclusion Criteria:

 -  Previous systemic treatment with biologics other than efalizumab, within 3 months.

 -  Treatment with any systemic corticosteroids or intra-articular corticosteroid
 injection, cyclosporine or methotrexate within 28 days.

 -  Any previous treatment with chlorambucil or cyclophosphamide.

 -  Have active tuberculosis or are currently receiving treatment or prophylactic therapy
 for tuberculosis.

 -  Have other serious disorders; such as, congestive heart failure, prior or current
 history of blood dyscrasia, or central nervous system demyelinating disorders.

 -  Has a sensitivity, intolerance, or history of gastrointestinal bleeding associated
 with diclofenac, indomethacin, and/or ibuprofen.