Evaluation of Repetitive Transcranial Magnetic Stimulation as an Adjunct to Modified Constraint Induced Movement Therapy in Improving Upper Limb Function in Children With Hemiparetic Cerebral Palsy Aged 5 - 18 Years
Evaluation of Repetitive Transcranial Magnetic Stimulation as an Adjunct to Modified Constraint Induced Movement Therapy in Improving Upper Limb Function in Children With Hemiparetic Cerebral Palsy Aged 5 - 18 Years
The investigators aim to evaluate efficacy of TMS as an adjunct to CIMT, assess its safety
 and tolerability and study cortical excitability with help of TMS which are both
 rehabilitative therapies for hemiplegic cerebral palsy.
Cerebral palsy is the most common motor disability of childhood and Hemiparetic cerebral
 palsy accounts for about one third of cases. Improving spasticity and upper limb function in
 these children can lead to better functional outcome and quality of life. TMS is an upcoming
 rehabilitative modality which has shown promising results in western studies. It has benefits
 of being non-invasive and has shown to have additive effect when used with CIMT which is
 standard of care in hemiparetic CP. However, randomized controlled clinical trials comparing
 it with CIMT alone in hemiparetic CP are very few, none from India so far. The dose, type and
 duration of TMS and its feasibility in resource limited set up needs to be investigated in
 children .Therefore, the investigators aim to evaluate efficacy of TMS as an adjunct to CIMT,
 assess its safety and tolerability and study cortical excitability with help of TMS.
Inclusion Criteria:

 -  • Age 5 - 18 years

 -  Hemiparetic Cerebral Palsy (perinatal brain injury)

 -  Intelligence Quotient >70 (Binet Kamat Test/Malin's Intelligence Scale for
 Children)

 -  Modified Ashworth scoring 1-3 for affected limb

 -  Can sit independently or with support (GMFCS stage : 1-4 and Manual Ability
 Classification System stage: 1-3)

 -  Preserved vision and hearing (with or without correction)

 Exclusion Criteria:

 -  • Uncontrolled epilepsy as defined by seizure frequency >1/month for preceding 3
 months

 -  Severe concurrent illness or disease not associated with CP or unstable medical
 conditions like pneumonia

 -  Genetic or syndromic associations

 -  Children diagnosed with Autistic Spectrum Disorders

 -  Modified Ashworth Scale Score more than 3 at shoulder/elbow/wrist

 -  Contractures of affected limb

 -  Severe movement disorder like dystonia, choreo-athetosis or ballismus interfering
 with purposeful limb movement

 -  Any congenital brain malformation detected on conventional MRI brain

 -  Recent surgery/cast/splint in affected limb

 -  Botulinum toxin/phenol block in affected limb in past 6 months or planned to
 receive in study period

 -  Those receiving tone modifying agents within two weeks before enrolment
 (Tizanidine, baclofen, benzodiazepines, dantrolene)

 -  mCIMT received in last 6 months

 -  Any contraindications for TMS - implanted electronic device and non-removable
 metallic objects near coil e.g. Pacemaker, cochlear implant