Hemodynamic Effects of Normobaric Hypoxia During Exercise in Patients With Pulmonary Hypertension
Hemodynamic Effects of Normobaric Hypoxia During Exercise in Patients With Pulmonary Hypertension
To study hemodynamic effects of acute normobaric hypoxia during exercise in patients with
 pulmonary hypertension in a single-center randomized controlled trial.
Inclusion Criteria:

 -  Informed consent as documented by signature (Appendix Informed Consent Form)

 -  PH class I (PAH) or IV (CTEPH) diagnosed according to guidelines: mean pulmonary
 artery pressure >20 mmHg, pulmonary vascular resistance ≥3 wood units, pulmonary
 arterial wedge pressure ≤15 mmHg during baseline measures at the diagnostic
 right-heart catheterization

 Exclusion Criteria:

 -  resting partial pressure of oxygen <8 kilopascal at Zürich altitude on ambient air

 -  exposure to an altitude >1000 m for ≥3 nights during the last 2 weeks before the study

 -  inability to follow the procedures of the study

 -  patients who take nitrates

 -  other clinically significant concomitant end-stage disease (e.g., renal failure,
 hepatic dysfunction)