Influence of Adiponutrin in Chronic Liver Disease
Influence of Adiponutrin in Chronic Liver Disease
Increasing evidence attests the influence of multiple metabolic genetic risk factors in the
 progression of alcoholic liver disease. Deleterious pathways involved in metabolism such as
 lipid peroxidation and cytokines have been implicated in promoting inflammation leading to
 fibrosis increase and liver injury progression. The aim of this study was to assess the role
 of rs738409 single nucleotide polymorphism in the PNPLA3 gene in alcoholic liver disease
 patients.
ALD patients:

 Inclusion Criteria:

 -  Excess alcohol intake

 -  Abnormal alanine aminotransferase (ALT) and aspartate aminotransferase (AST) or a
 suspicion of cirrhosis related to ALD

 -  Caucasian ethnicity

 Exclusion Criteria:

 -  Presence of any other chronic liver disease

 -  Co-infection with human immunodeficiency virus

 Controls:

 Inclusion Criteria:

 -  Caucasian ethnicity

 Exclusion Criteria:

 -  Presence of a disease