Research of Diagnostic Value for BMJ Infants
Research of Diagnostic Value for BMJ Infants
Breast milk jaundice (BMJ) is the main cause of neonatal hyperbilirubinemia. Excessive serum
 unconjugated bilirubin level will not only cause the interruption or early termination of
 breastfeeding, but also cause kernicterus. Which can cause long-term dysfunction in infants.
 But for a long time, BMJ diagnosis has relied on clinical exclusive methods, lack of
 objective and reliable laboratory indicators. Which leads to misdiag. This project is a
 single-center, prospective nested case-control study. It is planned to establish a neonatal
 BMJ cohort. According to the admission criteria, 100 cases of early-onset BMJ and late-onset
 BMJ will be completed, and 100 healthy controls collected during the same period. , Compare
 the detection results of fecal miRNA and intestinal flora of the two groups of BMJ children
 and healthy controls, draw the ROC curve of the joint diagnosis, conduct research on the
 combined diagnostic value of fecal miRNA and intestinal flora analysis, and try to find the
 feasibility and practical value of diagnostic markers for feces in infants with BMJ.
This project is a single-center, prospective nested case-control study to investigate
 feasibility and practical value of diagnostic markers in infants with BMJ.

 According to the admission criteria, 100 cases of early-onset BMJ, 100 late-onset BMJ and 100
 healthy controls will be selected. Their feces, peripheral venous blood and mothers' breast
 milk were collected for further testing. Compare the detection results of fecal miRNA and
 intestinal flora of the two groups of BMJ children and healthy controls, draw the ROC curve
 of the joint diagnosis, conduct research on the combined diagnostic value of fecal miRNA and
 intestinal flora analysis.

 This study is to find the objective and reliable laboratory indicators to diagnose BMJ.
Inclusion Criteria:

 -  All the following conditions must be met

 1. Term newborns admitted to hospital with "neonatal hyperbilirubinemia"

 2. Exclusive breastfeeding or mainly breastfeeding

 3. Exclude perinatal infection, G-6P-D deficiency, homoimmune hemolysis,
 polycythemia, scalp hematoma, intracranial hemorrhage, cholestasis, hypoglycemia,
 hypothyroidism, hypothermia, neonatal asphyxia, fetus Pathological jaundice
 factors such as delayed stool excretion.

 Exclusion Criteria:

 -  As long as any one of the following conditions should be excluded

 1. During the follow-up period, breastfeeding was terminated or the daily milk
 powder intake exceeded 200 ml.

 2. Other pathological jaundice was diagnosed during the follow-up period.

 3. Take probiotics during the sampling period.

 4. The guardian asked to withdraw from the study halfway.