Clinical Analysis of the Patients With Cavitary Pulmonary TB and Endobronchial TB in the PPM-UUH Cohort
Clinical Analysis of the Patients With Cavitary Pulmonary TB and Endobronchial TB in the PPM-UUH Cohort
This study is a retrospective cohort study. The purpose of this study is to investigate
 clinical features of the patients with the cavitary pulmonary tuberculosis (TB) and
 endobronchial TB from the patients who have been registered in this hospital for treatment
 and follow-up, as part of the "PPM Project (Private-Public Mix project) for Korean National
 Tuberculosis Control" introduced in Korea since 2007.
Cavitary pulmonary tuberculosis (TB) is known to remain its Infectivity for a longer period
 of time than the non-cavitary pulmonary TB, which is usually almost inactivated its
 infectivity within two weeks after the administration of the anti - TB drugs.

 However, there are few studies on this, so it is not known how long the infectivity persists,
 whether there is a correlation with the number of cavities or the size of the cavities
 between persistence of infectivity.

 Meanwhile, endobronchial TB is known also to be highly infectious, unlike simple pulmonary
 TB.

 It is not known how long infectivity can persist after the administration of anti-TB
 medication, and whether there is any difference in persistence of infectivity regarding the
 clinical characteristics of endobronchial TB.

 In this study, investigators will analyze the retrospective data analysis of UUH-PPM Cohort,
 a cohort of PPM project patients in the Ulsan University Hospital (UUH).

 The PPM project is a "Private-Public Mix project" for the eradication of tuberculosis from
 Korea, which the Korean government and private medical institutions have been conducting
 since 2007.
A. Cavitary Pulmonary TB Group

 Inclusion Criteria:

 1. Aged 18 years and older

 2. The patient who has the cavitary pulmonary TB

 Exclusion Criteria:

 1. Age < 18 years

 2. Any Malignant patient

 3. Patients with bacterial or viral or fungal pneumonia based on the judgment of the
 attending physician

 4. Patients who had a history of any pulmonary cystic lesion such as infected bulla,
 bullous emphysema

 5. Patients who were diagnosed with pulmonary fungal infection or previous its history or
 any documented culture of the fungus from a bronchial sample including sputum

 6. Patients who were diagnosed with bronchiectasis

 7. Patients who were diagnosed with NTM-PD (non-tuberculous mycobacterial pulmonary
 disease) or any documented culture of NTM from a bronchial sample including sputum

 8. Patients who were diagnosed with connective tissue disease such as Wegener's
 granulomatosis, SLE

 9. Patients who were diagnosed with TB destroyed lung

 10. Patients who were diagnosed with congenital lung disease such as Congenital Cystic
 Adenomatoid Malformation (CCAM), pulmonary sequestration

 11. Patients who were diagnosed with interstitial lung disease such as
 Lymphangioleiomyomatosis (LAM), idiopathic pulmonary fibrosis (IPF)

 12. Patients who were diagnosed with culture-negative pulmonary TB

 13. Patients who did not take anti-TB medication more than twice a week on average

 14. Patients who were diagnosed with sarcoidosis

 15. Patients who were diagnosed with paragonimiasis

 16. Patients who were diagnosed with pulmonary thromboembolism due to excluding pulmonary
 infarction

 17. The patient who did not consent

 18. Patients who were diagnosed with MDR/XDR TB through AFB culture

 B. Endobronchial TB Group

 Inclusion Criteria:

 1. Aged 18 years and older

 2. The patient who has the endobronchial TB through bronchoscopy

 Exclusion Criteria:

 1. Age < 18 years

 2. Patient who was not consented