AVAD: Asthma With Small Airways Dysfunction
AVAD: Asthma With Small Airways Dysfunction
The aim of the study is to describe asthma phenotype with small airways dysfunction, in a
 multiparametric manner, with clinical, biological, morphological and genetic elements
 compared with asthma with proximal airways obstruction.

 The objective of this study is also to complete the clinical, immunobiological and
 morphological analysis of asthma with small airways dysfunction.
General Inclusion Criteria:

 -  man or woman

 -  age ≥ 18 years

 -  asthma

 -  inform consent signed

 -  affiliated to health insurance

 Specific inclusion criteria : asthma with proximal airways obstruction GROUP

 -  Maximal Voluntary Ventilation (MMV)<80%

 -  MMV / Forced Vital Capacity (FVC)≤70%

 -  Carbon Monoxide Transfer Coefficient (KcO)>80%

 Specific inclusion criteria : asthma with small airways dysfunction GROUP

 -  Maximal Voluntary Ventilation (MMV)≥80%

 -  MMV / Vital Capacity(VC)>70%

 -  Carbon Monoxide Transfer Coefficient (KcO)>80%

 General Exclusion Criteria:

 -  pregnant woman or breastfeeding

 -  patient participating to other biomedical research

 -  patient who have participated to other biomedical research within the past 3 months

 -  patient refusing to sign the inform consent

 Specific exclusion criteria :

 -  Patient who stopped smoking since less than 12 months

 -  Pathological state related to obstructive distal airway damage

 -  Broncho-pulmonary infectious disease within the past 4 weeks

 -  Solid tumor curated by chemotherapy or chest radiotherapy

 -  Chronic respiratory disease

 -  Asthma exacerbation within the past 3 months

 -  Oral or systemic corticotherapy within the past 3 months