Bone Healing During Ninlaro Exposure
Bone Healing During Ninlaro Exposure
The primary purpose of this study is to investigate if treatment with Ixazomib in multiple
 myeloma (MM) can strengthen the bones, thus making it resilient to future fractures. Ixazomib
 will be given at a time point when the disease is in a stable phase, decreasing the
 likelihood that the potential bone anabolic effect will be abrogated by catabolic effect of
 active MM. In order to be included in the study, the patient must have treatment demanding
 MM, and the disease must have been brought into at least partial remission with chemotherapy
 before inclusion. Moreover, the patient must have pathological bone structure on low dose CT
 due to the pre-existing disease.
The primary purpose of this study is to investigate if treatment with Ixazomib in multiple
 myeloma (MM) can strengthen the bones, thus making it resilient to future fractures. Ixazomib
 will be given at a time point when the disease is in a stable phase, decreasing the
 likelihood that the potential bone anabolic effect will be abrogated by catabolic effect of
 active MM. In order to be included in the study, the patient must have treatment demanding
 MM, and the disease must have been brought into at least partial remission with chemotherapy
 before inclusion. Moreover, the patient must have pathological bone structure on low dose CT
 due to the pre-existing disease.
Inclusion Criteria:

 -  Symptomatic Multiple Myeloma according to the IMWG criteria.

 -  Detectable osteolysis on low dose CT (at least 5 mm in size).

 -  Stable disease, defined as no signs of progressive disease for three months without
 anti myeloma treatment.

 -  Achieved, partial response or better, during last line of therapy.

 -  Signed informed consent.

 -  Age ≥ 18 years.

 -  Remaining life expectancy ≥ 6 months.

 -  ECOG performance status 0-2.

 Female patients who

 -  Are postmenopausal for at least 1 year before the screening visit, OR

 -  Are surgically sterile, OR

 -  If they are of childbearing potential, agree to practice 2 effective methods of
 contraception, simultaneously, from the time of signing the informed consent form
 through 90 days after the last dose of study drug, OR

 -  Agree to practice true abstinence when this is in line with the preferred and usual
 lifestyle of the subject. (Periodic abstinence (eg, calendar, ovulation,
 symptothermal, post-ovulation methods) and withdrawal are not acceptable methods of
 contraception).

 Male patients, even if surgically sterilized (i.e., status post-vasectomy), must agree to
 one of the following

 -  Agree to practice effective barrier contraception during the entire study treatment
 period and through 90 days after the last dose of study drug, OR

 -  Agree to practice true abstinence when this is in line with the preferred and usual
 lifestyle of the subject. (Periodic abstinence (eg, calendar, ovulation,
 symptothermal, post-ovulation methods) and withdrawal are not acceptable methods of
 contraception).

 Exclusion Criteria:

 -  Treatment with Denosumab within the last 4 weeks.

 -  Known concurrent malignancy (last five years), excluding skin cancer.

 -  Known hypersensitivity to Ixazomib.

 -  Central nervous system involvement.

 -  Ongoing or active systemic infection, active hepatitis B or C virus infection, or
 known human immunodeficiency virus (HIV) positive Pregnant or lactating women

 -  Absolute neutrophil count < 1,000mm3 without growth factor support.

 -  Platelet count < 75,000/mm3. Platelet transfusions to help patients meet eligibility
 criteria are not allowed within 3 days before inclusion -Total bilirubin > 1.5 x the
 upper limit of the normal range.

 -  Alanine aminotransferase > 3 x upper limit of the normal range.

 -  Calculated creatinine clearance < 30 mL/min (using the Cockcroft-Gault equation).

 -  Total bilirubin > 1.5 the upper limit of the normal range (ULN).

 -  Radiotherapy within 14 days before inclusion.

 -  Major surgery within 14 days before inclusion.

 -  Evidence of current uncontrolled cardiovascular conditions, including uncontrolled
 hypertension, uncontrolled cardiac arrhythmias, uncontrolled congestive heart failure,
 unstable angina, or myocardial infarction within the past 6 months.

 -  Systemic treatment with strong CYP3A inducers (rifampin, rifapentine, rifabutin,
 carbamazepine, phenytoin, phenobarbital) or use of St. John's wort.

 -  Peripheral neuropathy grade 1 with pain or grade 2.

 -  Participation in other clinical trials, including those with other investigational
 agents not included in this trial, within 30 days of the start of this trial and
 throughout its.

 -  Known GI disease or GI procedure that could interfere with the oral absorption or
 tolerance of Ixazomibzomib including difficulty swallowing.

 -  Infection requiring systemic antibiotic therapy or other serious infection within 14
 days before study enrollment.