2-Chlorodeoxyadenosine and Cytarabine in Patients With Idiopathic Hypereosinophilic Syndrome (HES)
2-Chlorodeoxyadenosine and Cytarabine in Patients With Idiopathic Hypereosinophilic Syndrome (HES)
Primary Objectives:

 1. To determine the response rate, progression-free survival (PFS) and overall survival of
 patients who receive 2-CdA + Ara-C.

 2. To examine if there is any clonality in the cytokine expression of helper T cells or
 cytokine receptor expression of eosinophils.

 3. To determine the effect of 2-CdA on accumulation of Ara-C triphosphate in eosinophils.
Before the study begins, patients will have a physical exam, blood tests, and urine tests.
 Women will have a pregnancy test. A bone marrow sample will be taken. This is done with a
 large needle. Heart tests and an MRI scan of the brain will be done if there is a suspicion
 of disease in the heart or central nervous system.

 Patients in this study must have a catheter (thin tube) placed in a vein in the arm or under
 the collarbone. This tube will be left in place throughout the study. 2-CdA (Cladribine) will
 be given through the catheter 24 hours a day on days 2 to 6. Ara-C (Cytarabine) will be given
 through the catheter over 2 hours on days 1, 3, 4, 5, and 6. Starting on day 9, patients will
 inject G-CSF under their skin once a day; G-CSF helps blood counts return to normal.
 Treatment will be given on an inpatient or outpatient basis. The first course is normally
 done inpatient.

 During the study, patients will have blood tests daily during the first week and every other
 day after that. Bone marrow samples will be taken on days 14, 21, and 28. Further bone marrow
 samples may be necessary to evaluate response. Heart tests and MRI scans of the brain may be
 done.

 This is an investigational study. G-CSF, 2-CdA, and Cytarabine are approved by the FDA for
 treatment of cancer. Up to 40 patients will take part in this study. Patients will be treated
 at M. D. Anderson or other centers. A total of 40 people will take part in this study. About
 1 patient every 3 months will be enrolled at M. D. Anderson.
Inclusion Criteria:

 1. Patient must have diagnosis of idiopathic HES, defined as (1) no recent history of
 allergic reaction or parasitic infection; (2) sustained (> 6 months) hypereosinophilia
 (1,500/mm^3); and (3) signs or symptoms of organ involvement.

 2. Age less than 76 years old.

 3. Patient is not pregnant.

 4. Zubrod performance status < 3.

 5. Life expectancy is not severely limited by concomitant illness.

 6. Serum creatinine < 2 mg/dL.

 7. Serum bilirubin < 2 times upper limit of normal (2 mg/dL).

 8. Alanine aminotransferase (SGPT) < 2 times upper limit of normal (112 IU/L).

 9. Participant has completed the informed consent process, understands the
 investigational nature of the study, agrees to participate, and has signed the
 informed consent.

 Exclusion Criteria:

 1. Evidence of chronic active hepatitis or cirrhosis, and > 1 month from prior episode of
 hepatitis.

 2. Presence of an active infection.

 3. HIV positive.

 4. Has eosinophilic leukemia (defined by presence of clonal cytogenetic abnormalities).

 5. Recent history of parasite infection.

 6. Recent history of allergic reaction.