A Study in Ovarian, Non-Small Cell Lung, Prostate, Colorectal, Gastroesophageal Cancers, and Squamous Cell Carcinoma of the Head and Neck
A Study in Ovarian, Non-Small Cell Lung, Prostate, Colorectal, Gastroesophageal Cancers, and Squamous Cell Carcinoma of the Head and Neck
The purpose of the study is to estimate the rate of response for patients with ovarian,
 non-small cell lung, prostate, colorectal, gastroesophageal, and head and neck cancers who
 are administered LY2523355.
Inclusion Criteria:

 -  Diagnosis of ovarian, non-small cell lung, prostate, colorectal, gastroesophageal
 cancer (adenocarcinoma of the esophageal cancer, stomach, or gastroesophageal
 junction), or squamous cell cancer of the head and neck

 -  Have measurable disease defined by Response Evaluation Criteria in Solid Tumors
 (RECIST) 1.1 guidelines (except prostate cancer participants)

 -  Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1

 -  Are willing to follow study procedures for the duration of the study

 -  Are willing to use an approved contraceptive method during treatment and for 3 months
 after discontinuation of study treatment

 Exclusion Criteria:

 -  Have a serious preexisting medical condition that would preclude participation in the
 study

 -  Are pregnant or lactating

 -  Have received treatment within 28 days of first dose of LY2523355 with a drug that has
 not received regulatory approval for any indication

 -  Have symptomatic, untreated, or uncontrolled central nervous system (CNS) metastases

 -  Have a second active primary malignancy or a history of a second malignancy requiring
 cytotoxic therapy

 -  Have QTc interval greater than 470 millisecond (msec) or intraventricular conduction
 delay (IVCD) with QRS greater than 120 msec on screening electrocardiogram (ECG)

 -  Have active symptomatic fungal, bacterial, and/or known viral infection including
 active human immunodeficiency virus (HIV) or viral (A, B, C) hepatitis

 -  Participants with pneumonia, evidence of obstructive pneumonitis, other respiratory
 infections, or infection from other sources are to be excluded