Alcohol Self-reporting During Pregnancy. AUTOQUEST Study.
Alcohol Self-reporting During Pregnancy. AUTOQUEST Study.
The effects of alcohol consumption during pregnancy have been known for decades. However,
 alcohol consumption in pregnant women remains today a public health problem and its
 identification is primordial. During pregnancy, standardized self-reports such as T-ACE would
 help identify early women with high-risk alcohol consumption. T-ACE appears to be one of the
 most used during pregnancy but its diagnostic value is not objectively known.

 To evaluate the diagnostic value of T-ACE self-report in the detection of high-risk alcohol
 consumption during pregnancy, by comparison with the dosage of a biomarker in blood.

 Material and methods Multicentric diagnostic prospective study of 2425 pregnant women
 followed in 3 hospitals of North of France. The self-report will be offered to all women
 during their prenatal consultation in these 3 maternity clinics. When they returned their
 self-report to the medical practitioner, a unique blood test of phosphatidylethanol will be
 proposed to them for a period of one year. Made after informed consent, this dosage will be
 used as a gold standard of an alcohol consumption during the previous three weeks to
 establish the diagnostic value of T-ACE. An alcohol consumption will be considered " at high
 risk " if blood phosphatidylethanol is ≥ 20 µg/L.

 With a predictable 25% rejection rate and a positive 4% T-ACE frequency, the inclusion of
 2425 patients should permit to estimate sensitivity, specificity, positive predictive value
 (PPV) and negative predictive value (NPV) of T-ACE with a satisfactory 95% confidence
 interval in this population.

 The evidence of a link between positive T-ACE and real high-risk alcohol consumption in
 pregnant women would objectively validate the use of this self-report during pregnancy.

 The T-ACE within the self-report (self-administered questionnaire) set up in these 3
 maternity hospitals in the North of France is already a reference thanks to its several
 advantages to better identify psychosocial risk situations and especially high-risk alcohol
 consumption during pregnancy than medical history. If T-ACE appeared to be a sensitive and
 specific method for identifying high-risk alcohol use during pregnancy, it could be
 generalized in the follow-up of pregnant women in our country.
Inclusion Criteria:

 -  pregnant woman over 18 years old, presenting in one of the three maternities of the
 study for her prenatal care

 -  and having returned her self-report

 -  and having given her written consent

 -  no exclusion criteria

 Exclusion Criteria:

 -  woman under 18 years old

 -  or not pregnant

 -  or not having returned her self-report

 -  or woman who refused to participate in the study (absence of written consent)