Growth Hormone Treatment of Women With Turner Syndrome
Growth Hormone Treatment of Women With Turner Syndrome
Growth hormone treatment is used in girls with Turner syndrome to increase final height. The
 aim of this study is to evaluate the effect of growth hormone treatment on body composition
 and heart function in adult women with Turner syndrome. The hypothesis is that the fat mass
 will decrease and lean body mass will increase. There is only very limited documentation of
 the effect on the heart in this study population.
This study is a randomised, double-blinded, controlled clinical trial to evaluate the effect
 of growth hormone (GH) treatment on adult women with Turner syndrome. The endpoints will be
 changes in body composition and heart function evaluated by echocardiography (ECHO) and
 positron emission tomography (PET).

 Phase one: 6 months of GH or placebo treatment. Phase two: "open label" all participants are
 treated with GH for 12 months. At baseline, healthy controls will be examined, but will not
 receive any treatment
Inclusion Criteria:

 -  Turner syndrome

 -  Age 20-40

 Exclusion Criteria:

 -  Symptomatic heart disease

 -  Anti hypertensive treatment

 -  Untreated thyroid disease

 -  Adipositas (BMI > 35)

 -  Treatment with glucocorticoids

 -  Pregnancy