Meal Stimulating After Roux-en Y Gastric Bypass
Meal Stimulating After Roux-en Y Gastric Bypass
In many studies, gastric bypass surgery led to total remission of type 2 diabetes (T2DM) as
 early as 1 - 2 days after surgery before any real weight loss has occurred. This suggests
 that the remission of the T2DM is due to the direct effect of the operation, more than the
 secondary effect of the weight loss. The reasons for the major effect on the glucose
 metabolism after gastric bypass surgery are still unaccounted for.

 The aim of this project will be to unveil some of the mechanisms that explain the effect of
 gastric bypass surgery on the glucose metabolism. Further more to find a better way of
 testing patients that have just undergone gastric bypass surgery. It is not possible to test
 patients who have just undergone gastric bypass surgery with normal oral glucose tolerance
 test (OGTT) and a normal meal, because patients can only take in fluid and a normal OGTT will
 often lead to dumping. Instead we will try to modify these tests - OGTT with lower glucose
 level and meal-testing with a protein drink.

 The hypothesis of the study is that the investigators can see changes in different hormones
 and adipokines before and after surgery, even with modified OGTT and meal testing. The
 project will consist of clinical trials on patients without T2DM that will undergo gastric
 bypass surgery. The studies will take place before and within the first week after surgery.
 The investigators will measure different hormones and adipokines after OGTT and a meal with a
 protein drink. The investigators expect to see significant changes in some of the analyses
 after the operation in patients undergoing gastric bypass.
Inclusion Criteria:

 -  Obese with BMI> 40 undergoing gastric bypass surgery OR

 -  Obese with BMI > 35 with complications of their obesity in form of high blood pressure
 or other related complications undergoing gastric bypass surgery

 -  Age between 20-60 years

 Exclusion Criteria:

 -  Age > 60

 -  Diabetes

 -  Psychiatric illness

 -  Mentally challenged

 -  Addiction

 -  Serious cardiac or lung diseases

 -  Diseases in the abdomen

 -  Other serious illness