Distribution of Smooth Muscle In Dartos In The Non Conspicuous Penis
Distribution of Smooth Muscle In Dartos In The Non Conspicuous Penis
Non-conspicuous penis (congenital megaprepuce, occult penis) is a symptomatic malformation
 that includes phimosis and excessively baggy, urine-filled prepuce with alteration of the
 appearance of the penis. A redundant and enlarged foreskin is the main feature of this
 entity.This congenital anomaly is difficult to diagnose and may have association with other
 pathologies such as buried penis.

 Currently, part of the megaprepuce skin is used to correct the defect. A recent study shows
 that patients with this pathology and hypospadias present mostly defects in the muscle
 dartos. The investigators do not know the physiological bases of the megaprepuce, neither the
 clinical and aesthetics implications of this abnormal tissue for the patient, and how this
 affects the postoperative evolution. With the present study the investigators intended to
 answer these questions and to open paths for future research in this area.
After informed consent, patients will be labeled with a research record number other than the
 identity document or the number of the attention. The urologist who perform the correction of
 the megaprepuce, will take a segment of the dartos and send it for histopathological
 analysis: staining with hematoxylin-eosin, smooth muscle actin marker, associated with the
 research record number. Same procedure will be performed with the controls and hypospadias
 group. Only the principal investigator will know the assignment of medical record and their
 respective group (congenital megaprepuce, hypospadias or controls). The samples will be sent
 to pathology without any clinical data, and they will be analyzed by two pathologists, both
 blind.
Inclusion Criteria:

 -  Male patients scheduled for correction of congenital megaprepuce

 -  Male patients scheduled for correction of hypospadias

 -  Male patients scheduled for circumcision for non-medical reasons.

 Exclusion Criteria:

 -  Patients with a history of hypospadias correction.