Simvastatin and Metformin Therapy in PCOS Women. Prospective Randomised Trial.
Simvastatin and Metformin Therapy in PCOS Women. Prospective Randomised Trial.
The purpose of this study is to compare effects of statins (simvastatin) and metformin on
 clinical (menstrual cycle, excessive hair, skin problems), endocrine (androgens), metabolic
 (lipids, markers of systemic inflammation), and endothelial function parameters in women with
 polycystic ovary syndrome (PCOS).
Inclusion Criteria:

 -  PCO - ESHRE/ASRM criteria:oligomenorrhea (<8 spontaneus menses per year) and
 hyperandrogenism(hirsutism or acne) or hyperandrogenemia(testosterone > 70 ng/ml)
 normal prolactin, TSH, 17-OH progesterone no evidence of androgen producing
 malignancy, Cushing's syndrome or acromegaly age 18-40 reliable use of birth control
 pill for at least 3 months and no plans of pregnancy

 Exclusion Criteria:

 -  elevated creatinine kinase above 2 times upper limit of normal or liver enzymes
 (transaminase) above 2 times of upper limit of normal use of any following
 medications: cyclosporine, fibrates niacin,antifungal agents, macrolide antibiotics
 use of oral contraceptives and other steroid hormones 3 months prior to the study