Effect of Mouth Rinses in Oral Malodor
Effect of Mouth Rinses in Oral Malodor
Bad breath or halitosis is caused by specific gases originating from the mouth or the expired
 air. In most cases the pathology lies within the mouth and in this case receives the name
 pathologic halitosis of oral cause or oral malodor. The aim of this study is to evaluate the
 immediate (masking) and long term (therapeutic) effect of commercially available mouth rinses
 in the treatment of oral malodor. For this volunteers with oral malodor detected by
 organoleptic evaluation and confirmed by the increase level of sulphur compounds in their
 breath (VSC) will be asked to use a designated mouthwash. The breath parameters will be
 assessed at baseline and 15' after the first rinse (15 ml, during 1 minute) and over night at
 the end of a period of 3 weeks during which the volunteers rinsed twice a day (15 ml, 1
 minute) with the assigned mouthwash. The short and long term effect of a stannous
 fluoride/amine fluoride/zinc rinse; a chlorhexidine/cetylpyridinium chloride/zinc product and
 a negative control(fluoride rinse and/or water) will be compared.
Inclusion Criteria:

 -  Caucasian

 -  Age ≥ 18 years

 -  Organoleptic score of breath ≥ 2

 -  VSC readings (sum of H2S and CH3SH by OralChroma) ≥ 120 ppb*

 -  Intra-oral cause of bad breath

 -  Non-smokers

 -  Willing to participate and able to give written informed consent

 Exclusion Criteria:

 -  Ongoing dental treatment or any other medical treatment of the oral cavity

 -  Any known allergy to previously used oral hygiene products or any known allergy to any
 of the ingredients of the study products, which are used during the study

 -  Any pathological change of the oral mucosa

 -  Use of prohibited treatments / therapies and/or abuse of drugs, alcohol, etc

 -  Pregnancy or breastfeeding

 -  Active caries

 -  Acute sinusitis

 -  Severe oro-pharyngeal infections

 -  On medications which can cause malodour

 -  Reduced salivary flow due to pathological reasons (e.g. Sjögren syndrome)

 -  Situation considered not compatible with the study according to the investigator's
 opinion; the latter includes: patients eating very spicy food, persons under
 homeopathic therapy, patients who used antibiotics during the 2 months before the
 study, patients frequently using chewing gum, patients under corticosteroids or other
 serious medications.

 -  Patients unwilling to abstain from additional oral hygiene (only toothbrushing
 allowed) particularly mouthrinse, chewing gums, breath strips, etc