Chinese ET Registry (CETR)
Chinese ET Registry (CETR)
The purpose of the Chinese Essential Tremor Registry (CETR) is to develop a database of
 patients with Essential tremor in China.
Essential tremor (ET) is one of the most common movement disorders and affects approximately
 1% of the population worldwide. Twin and family history studies show a high heritability for
 essential tremor. The molecular genetic determinants of essential tremor are unknown. Some
 mutations have been found in ET families but have not been validated in others. The
 pathophysiological basis of ET remains unknown. In 2017, a task force of the International
 Parkinson and Movement Disorder Society proposed a new formal definition of essential tremor
 as a syndrome of isolated tremor of both upper limbs with a duration of at least 3 years,
 with or without tremor in other locations, such as head, larynx (voice tremor), or lower
 limbs. Defining essential tremor as a syndrome and not as a single disease, while
 concomitantly narrowing its phenotypic scope to increase its homogeneity, recognizes that
 there are multiple possible causes, which may facilitate progress in understanding the
 pathogenesis. Investigators aim to establish a database of longitudinal recruited ET cohort,
 and characterize the clinical feature, genetic basis, environmental factors and their
 interactions among different ET subtypes in China, identify natural history of a
 highly-presentative Chinese ET cohort and to discern major milestones in the disease process
 which indicates disease progression.

 Data were collected at baseline. Information about detailed disease history, level of
 education, significant chronic comorbidities, physical examination, medication history,
 family history, living habits and toxic exposure history, which include smoking, drinking
 tea, alcoholic consumption, drinking coffee, exposure to pesticide or occupational solvent,
 history of carbon monoxide poisoning and recurrent head trauma will be recorded at baseline.
 For each evaluation, the same questionnaires will be conducted. A standardized neurological
 assessment according to the recommendation of Consensus on the construction of clinical
 database of Parkinson's disease and movement disorders in China.

 The Essential Tremor Rating Assessment Scale (TETRAS) includes both performance and
 Activities of Daily Living (ADL) subscales. It is conducted for the clinical measurement of
 ET severity and tremor's impact on ADL. The non-motor symptoms are evaluated by Non-motor
 Symptom Scale (NMSS).Functional constipation was diagnosed by the Rome III diagnostic
 criteria. Excessive daytime sleepiness was evaluated by Epworth Sleepiness Scale (ESS).
 Probable rapid eye movement sleep behavior disorder (p-RBD) was diagnosed by rapid eye
 movement sleep behavior questionnaire-Hongkong (RBDQ-HK). Restless leg syndrome (RLS) was
 diagnosed with the Cambridge Hopkins Restless Leg syndrome questionnaire (CH-RLSq). Cognitive
 assessment was used the previously validated scale, Mini Mental State Examination (MMSE).
 Olfaction test was carried out by Hyposmia Rating Scale (HRS), a proportion of patients was
 also ascertained by Sniffin's Sticks. Depression was diagnosed by Hamilton Depression Scale
 (HAMD).DNA samples extracted from peripheral blood and all the ET patients will be examed by
 Whole Exome Sequencing or Whole-genome sequencing. All the participants are scanned by
 structural MRI to exclude obvious intracranial lesions and other metabolic disorders, etc.
Inclusion Criteria:

 -  Patients diagnosed with ET by the Consensus Statement on the Classification of
 Tremors,From the Task Force on Tremor of the International Parkinson and Movement
 Disorder Society.

 Exclusion Criteria:

 -  Lack of capacity to consent to participate in the project.