The Relationship Between Clotting Factor VIII and Bleeding Adverse Reactions in Patients Under the Therapies of Thrombolysis, Anticoagulation and Anti-platelet
The Relationship Between Clotting Factor VIII and Bleeding Adverse Reactions in Patients Under the Therapies of Thrombolysis, Anticoagulation and Anti-platelet
The purpose of this study is to determine whether Plasma Factor VIII Levels are related to
 the treatment of bleeding in ischemic stroke（IS）.
Clear cerebral infarction patients during hospitalization, treatment process, discharge and
 hemorrhage occurs, the stages F VIII level change and its correlation with bleeding adverse
 reactions. Analysis F VIII whether belong to hemorrhage occurs independent risk factors of
 adverse drug reactions,as well as the feasibility of predicting bleeding occurred adverse
 reaction index.
Inclusion Criteria:

 -  Guidelines prepared by the diagnostic criteria(according to the diagnostic criteria of
 the Fourth National Stroke Conference prepared,have been more than one times skull CT
 and/or MRI)was confirmed for ischemic stroke,and requires the use of antithrombotic
 therapy(including thrombolysis, anticoagulation, antiplatelet) patients

 -  Willing and able to comply with the study protocol and visits planned

 Exclusion Criteria:

 -  At the same time the presence of other active malignancy.

 -  There is known brain metastases or leptomeningeal metastases

 -  Systemic active infection ( ie infection leads to body temperature ≥38 ℃)

 -  The last 4 weeks there is a need drainage ascites, pleural effusion or pericardial
 fluid .

 -  Clinically significant obstruction , pulmonary fibrosis , kidney failure , liver
 failure and other diseases.

 -  Uncontrolled diabetes.

 -  Severe / unstable angina, New York Heart Association (NYHA) class III or IV symptoms
 of congestive heart failure

 -  there is other reason (not the antithrombotic drugs) caused by bleeding.

 -  The presence of an autoimmune disease or a history of organ transplant patients
 require immunosuppressive therapy

 -  Psychiatric presence may increase the risks associated with study participation or
 study drug , or may interfere with the interpretation of study results

 -  Pregnant and lactating women

 -  Bleeding disorders may exist on admission

 -  The researchers added that the study is not appropriate to the circumstances