Hypotonia and Neurofibromatosis Type 1 (NF1) Glioma
Hypotonia and Neurofibromatosis Type 1 (NF1) Glioma
Currently, optic pathway gliomas (OPG) are detected based on abnormal findings made during
 annual ophthalmologic exams. However, because these exams are annual, it is possible for
 healthcare providers to miss the point at which a child's vision begins to decline
 (potentially indicating an OPG). If at-risk children are screened for hypotonia early in
 life, those children who are hypotonic may undergo magnetic resonance imaging (MRI) to
 evaluate for OPG before they are showing ophthalmologic symptoms. This would enable
 healthcare providers to discover vision loss earlier and treat symptomatic OPGs earlier,
 thereby allowing us a better chance of preventing further vision loss in children with OPGs.
Inclusion Criteria:

 -  Patient must be seen at the St. Louis Children's Hospital NF Clinic

 -  Diagnosis of NF1

 -  Between 1 and 7 years of age, inclusive

 -  Diagnosed with hypotonia

 -  Legally authorized representative/guardian must be able to understand and willing to
 sign an IRB-approved informed consent document

 -  Must have an MRI scan ordered by a treating physician

 Exclusion Criteria:

 -  Normal tone on clinical exam

 -  Known allergy to gadolinium or the sedative, propofol, used during MRI

 -  Poor kidney function defined as a known renal disease or elevated BUN and creatine

 -  Requiring intubation for anesthesia