THE ASSOCIATION BETWEEN FATTY LIVER (NAFLD) DISEASE AND PCOS
THE ASSOCIATION BETWEEN FATTY LIVER (NAFLD) DISEASE AND PCOS
Since both pathologies (PCOS and NAFLD) involve disturbed carbohydrate economy, which revolve
 around insulin resistance, it is tempting to examine the specific "liver profile" of women
 with PCOD. Furthermore, it would be of great importance if lean women who suffer from PCOD
 would be revealed to shere cardiovascular risks with their more overweight peers.

 Patients - women who will be diagnosed with PCOD following their initial referal to our
 fertility clinic. Controls - normal ovulatory women who approached our fertility clinic due
 to either unexplained or male factor infertility.

 Workup - history for menstrual pattern; Clinical evaluation for features of hyperandrogenism;
 ultrasonographic documentation of ovarian morphology; follicular phase hormonal profile for
 validation of the diagnosis and for ruling out other pathologies which may cause anovulation.

 Liver profiling - The following blood tests will be used for the biochemical profiling:
 fasting glucose and insulin, CRP, HDL-cholesterol, triglycerides, AST, ALT, GGT, LDH,
 alkaline phosphatase, total bilirubin, direct bilirubin, ferritin, HBA1C and micro albumin
 ratio.

 FibroScan® will be used to measure liver stiffness.
Workup - history for menstrual pattern; Clinical evaluation for features of
 hyperandrogenism; ultrasonographic documentation of ovarian morphology; follicular phase
 hormonal profile for validation of the diagnosis and for ruling out other pathologies which
 may cause anovulation.

 Liver profiling - The following blood tests will be used for the biochemical profiling:
 fasting glucose and insulin, CRP, HDL-cholesterol, triglycerides, AST, ALT, GGT, LDH,
 alkaline phosphatase, total bilirubin, direct bilirubin, ferritin, HBA1C and micro albumin
 ratio.

 FibroScan® will be used to measure liver stiffness, as previously described