Comparison of PET and Proton MRS Imaging to Evaluate Pediatric Brain Tumor Activity
Comparison of PET and Proton MRS Imaging to Evaluate Pediatric Brain Tumor Activity
This study in children and young adults will compare two types of imaging, positron emission
 tomography ([(18)F]-DG PET) and proton magnetic resonance spectroscopy ((1)H-MRSI), to
 determine activity of a brain tumor or abnormal tissue in the brain following treatment for a
 brain tumor. Children with brain tumors are generally followed with magnetic resonance
 imaging (MRI) scans to evaluate response to treatment. However, because MRI only provides
 information on the structure of the brain, it may difficult to tell if an abnormal finding is
 due to tumor, swelling, scar tissue, or dead tissue. (1)H-MRSI and [(18)F]-DG PET, on the
 other hand, provide information on the metabolic activity of brain lesions. These two methods
 will be compared and evaluated for their ability to provide important additional information
 on childhood brain tumors.

 Patients between 1 and 21 years of age with a brain tumor or brain tissue abnormality
 following treatment for a brain tumor may be eligible for this study. Candidates will be
 screened with a medical history and physical examination, pregnancy test in women who are
 able to become pregnant, and a blood test for glucose.

 Participants will undergo the following procedures:

 (1)H-MRSI - This test is similar to MRI and is done in the same scanning machine. In MRI,
 scans of the brain are obtained by applying a strong magnetic field and then collecting the
 signals released from water after the magnetic field is changed. Pictures of the brain are
 then obtained by computer analysis of these signals. In (1)H-MRSI, the computer blocks the
 signal from water to get information on brain chemicals that can indicate whether an
 abnormality is tumor or dead tissue. Both MRI and MRI and (1)H-MRSI are done in this study.

 For these tests, the child lies on a stretcher that moves into the scanner - a narrow metal
 cylinder with a strong magnetic field. The child's head is placed in a headrest to prevent
 movement during the scan. He or she will hear loud thumping noises caused by the electrical
 switching of the magnetic field. A contrast agent is given through an intravenous (IV)
 catheter (plastic tube placed in an arm vein) or through a central line if one is in place.
 The contrast material brightens the images to provide a clearer picture of abnormalities.
 Children who have difficulty holding still or being in a scanning machine are given
 medications by an anesthesiologist to make them sleep through the procedure. Children who are
 awake during the procedure can communicate with the MRI technician at all times and ask to be
 removed from the scanner at any time. The MRI and (1)H-MRSI take 1-1/2 to 2 hours to
 complete.

 [(18)F]-DG PET - For this test, [(18)F]-DG (a radioactive form of glucose) is injected into
 the patient's arm vein through a catheter, followed by the PET scan, similar to a very open
 MRI scan without the noise. The PET scan tells how active the patient's tumor is by tracking
 the radioactive glucose. All cells use glucose, but cells with increased metabolism, such as
 cancer cells, use more glucose than normal cells. After the glucose injection, the patient
 lies quietly in a darkened room for 30 minutes, after which he or she is asked to urinate to
 help reduce the dose of radiation to the bladder. Then, the scan begins. When the scan is
 finished (after about 1 hour), the child is asked to urinate again and then every 3 to 4
 hours for the rest of the day.

 Patients remain in the study for 2 years unless they withdraw, become pregnant, or require
 sedation but can no longer use an anesthetic. MRI and 1H-MRSI scans may be repeated every few
 months during the study period, if necessary. Only one PET scan is done each year.
Background:

 -  Children with brain tumors are generally followed for response or progression by imaging
 studies, such as CT or MRI.

 -  While these imaging studies help delineate the anatomical location and extent of a tumor
 within the CNS, they give no information regarding the biologic or metabolic activity of
 the lesion.

 -  Proton Nuclear Magnetic Resonance Spectroscopic Imaging ((1)H-MRSI) is a non-invasive
 method of detecting and measuring cellular metabolites in vivo, providing biochemical
 information in conjunction with the spatial information obtained by MRI.

 -  Positron Emission Tomography (PET) is a technique that also provides data on metabolic
 activity of brain lesions.

 -  A comparison of these two methods in determining a lesion s metabolic activity has not
 been reported in children with brain tumors.

 Objective:

 -To compare (1)H-MRSI and [(18)F-]-FDG PET scanning percentage (%) of agreement between
 supratentorial and infratentorial tumors, and between brainstem and cerebellum intratentorial
 tumors.

 Eligibility:

 -  Age: greater than or equal to 1 year and less than to 21 years

 -  Patients must have a brain tumor that is measurable or evaluable on standard MRI or CT.

 Design:

 -  Patients referred for this study will have both (1)H-MRSI and (18)F-FDG PET imaging
 performed within 2 weeks of each other at the NCI

 -  Patients will remain on study for 5 years or until one of the off-study criteria have
 been met (whichever occurs first)
-  INCLUSION CRITERIA:

 1. Age: greater than or equal to 1 years and less than or equal to 21 years.

 2. Radiographic diagnosis: Patients must have a brain tumor (including, but not
 limited to high grade gliomas, low-grade gliomas, primitive neuroectodermal
 tumors, ependymomas) or residual abnormality (e.g. post-operatively or
 post-radiation) that is measurable or evaluable on standard MRI or CT.

 3. All patients or their legal guardians (if the patient is less than 18 years of
 age) must sign a document of informed consent indicating their awareness of the
 investigational nature and the risks of this study.

 4. Prior treatment: Patients will be eligible regardless of prior treatment.
 Therefore, patients who are newly diagnosed, post-operative, post-radiation or
 post-chemotherapy are eligible.

 EXCLUSION CRITERIA:

 1. Patients under age 18 years who weigh greater than 70 kg are excluded because they
 would exceed the standard allowable dosimetry for pediatric patients (i.e. Effective
 Dose greater than 0.5 REM/year). In addition, patients who weigh greater than 136 kg
 are excluded, as this is the maximum weight allowable on PET scanner tables.

 2. Pregnant or breastfeeding women

 3. Any patient who is unable (either because of physical or psychological factors) to
 undergo imaging studies without sedation but is not considered an anesthesia
 candidate.

 4. Any patient with a metallic MRI incompatible implant, including cardiac pacemakers,
 neural pacemakers, aneurysmal clips, shrapnel, cochlear implants or ferrous surgical
 clips.

 5. Any patient with a history of a severe reaction (CTC v.4 Grade greater than or equal
 to 2) to Gadolinium or other contrast agents.

 6. Any patient with Diabetes mellitus or steroid-induced hyperglycemia (fasting glucose
 greater than 150) because this may interfere with the interpretation of the
 [(18)F]-FDG PET scan.

 7. Any patient with permanent braces, permanent retainers or nonferrous implant that, in
 the judgment of the Principal Investigator, would interfere with obtaining
 spectroscopy in the area of the tumor.