Evaluation of COPD (Chronic Obstructive Pulmonary Disease) to Longitudinally Identify Predictive Surrogate Endpoints
Evaluation of COPD (Chronic Obstructive Pulmonary Disease) to Longitudinally Identify Predictive Surrogate Endpoints
This is a 3 year longitudinal study to identify novel endpoints and compare these with
 standard measures such as forced expiratory volume in 1 second (FEV1) for their ability to
 measure and predict COPD (Chronic Obstructive Pulmonary Disease) severity and its progression
 over time. Control subjects (smokers and never smokers) will be recruited as comparators with
 the COPD subjects.
Inclusion criteria:

 -  COPD Subjects

 -  A COPD subject will be eligible for inclusion in this study only if all of the
 following criteria apply:

 -  Male or female subjects, aged 40-75 years inclusive

 -  A baseline (post-bronchodilator) FEV1 <80% of predicted normal and a baseline
 (post-bronchodilator) FEV1/FVC ratio 70%

 -  Current or ex-smokers with a smoking history of at least 10 pack-years (number of pack
 years = (number of cigarettes per day / 20) x number of years smoked e.g., 20
 cigarettes per day for 10 years, or 10 cigarettes per day for 20 years).

 -  A signed and dated written informed consent is obtained prior to participation

 -  Able to comply with the requirements of the protocol and be available for study visits
 over 3 years

 Control Subjects - Current/Ex Smokers

 -  A control subject will be eligible for inclusion in this study only if all of the
 following criteria apply:

 -  Male or female subjects, aged 40-75 years inclusive, who are free from significant
 disease as determined by history, physical examination and screening investigations

 -  Baseline (post-bronchodilator) FEV1 >85% of predicted normal. FEV1/FVC ratio >70%

 -  Current or ex-smokers with a smoking history of at least 10 pack-years (number of pack
 years = (number of cigarettes per day / 20) x number of years smoked e.g., 20
 cigarettes per day for 10 years, or 10 cigarettes per day for 20 years).

 -  A signed and dated written informed consent is obtained prior to participation.

 -  Able to comply with the requirements of the protocol and be available for study visits
 over 3 years

 Control Subjects - Non-smokers

 -  A non-smoking control subject will be eligible for inclusion in this study only if all
 of the following criteria apply:

 -  Male or female subjects, aged 40-75 years inclusive, who are free from significant
 disease as determined by history, physical examination and screening investigations

 -  Baseline (post-bronchodilator) FEV1 >85% of predicted normal. FEV1/FVC ratio >70%

 -  Non-smokers with a smoking history of < 1 pack-year (number of pack years = (number of
 cigarettes per day / 20) x number of years smoked).

 -  A signed and dated written informed consent is obtained prior to participation.

 -  Able to comply with the requirements of the protocol and be available for study visits
 over 3 years

 Exclusion Criteria:

 COPD Subjects

 -  A COPD subject will not be eligible for inclusion in this study if any of the
 following criteria apply:

 -  Known respiratory disorders, or disorders identified at screening/visit 1 (including
 identification on the first CT scan), other than COPD (e.g.: lung cancer, sarcoidosis,
 tuberculosis, lung fibrosis, cystic fibrosis)

 -  Known history of significant inflammatory disease, other than COPD (e.g. rheumatoid
 arthritis and Lupus)

 -  Known to be severely alpha-1-antitrypsin deficient (PI SZ or ZZ)

 -  Having undergone lung surgery (e.g. lung reduction, lung transplant)

 -  Have cancer or have had cancer in the 5 years prior to study entry

 -  Serious, uncontrolled disease (including serious psychological disorders) likely to
 interfere with the study or impact on subject safety

 -  Is enrolled in a long term blinded drug study (subjects in open label studies may be
 considered and subjects in short blinded studies (approx less than 12 weeks may be
 considered following consultation with sponsor) or a study where there is significant
 radiation exposure (e.g.: CT scans)

 -  Have, in the opinion of the investigator, evidence of alcohol, drug or solvent abuse

 -  Have received a blood transfusion in the 4 weeks prior to study start

 -  Has experienced a moderate or severe exacerbation (requiring oral corticosteroid,
 antibiotics or hospitalisation) within the last 4 weeks. All courses of oral
 corticosteroids and antibiotics must be completed at least 2 weeks before study start

 -  Is on long term oral corticosteroids (long term is considered use for more than 3
 consecutive months)

 -  Unable to walk

 -  Subject is a participating investigator, sub-investigator, study co-ordinator, or
 employee of a participating investigator, or is an immediate family member of the
 aforementioned.

 Control Subjects

 -  A control subject will not be eligible for inclusion in this study if any of the
 following criteria apply:

 -  Known respiratory disorders, or disorders identified at screening/visit 1 including
 identification on the first CT scan (e.g.: COPD, asthma, lung cancer, sarcoidosis,
 tuberculosis, lung fibrosis)

 -  Known history of significant inflammatory disease (eg rheumatoid arthritis and Lupus)

 -  Known to be severely alpha-1-antitrypsin deficient (PI SZ or ZZ)

 -  Having undergone lung surgery (e.g. lung reduction, lung transplant)

 -  Have cancer or have had cancer in the 5 years prior to study entry

 -  Serious, uncontrolled disease (including serious psychological disorders) likely to
 interfere with the study

 -  Is enrolled in a long term blinded drug study (subjects in open label studies may be
 considered and subjects in short blinded studies (approx less than 12 weeks may be
 considered following consultation with sponsor) or a study where there is significant
 radiation exposure (e.g.: CT scans)

 -  Have, in the opinion of the investigator, evidence of alcohol, drug or solvent abuse.

 -  Have received a blood transfusion in the 4 weeks prior to study start

 -  Is on long term oral corticosteroids (long term is considered use for more than 3
 consecutive months)

 -  Subject is a participating investigator, sub-investigator, study co-ordinator, or
 employee of a participating investigator, or is an immediate family member of the
 aforementioned.