HoLEP Prior to Radiation Therapy for Patients With LUTS/Retention and Concurrent Prostate Cancer
HoLEP Prior to Radiation Therapy for Patients With LUTS/Retention and Concurrent Prostate Cancer
To determine if holmium laser enucleation of the prostate (HoLEP) for the treatment of lower
 urinary tract symptoms (LUTS) and/or urinary retention alters the treatment course for
 patients concurrently diagnosed with prostate cancer.
The investigators propose a prospective trial to investigate pre-radiation holmium laser
 enucleation (HoLEP) in men with bothersome lower urinary tract symptoms (LUTS) and prostate
 cancer who have elected for radiation therapy as the primary treatment modality for their
 prostate cancer. The investigators hypothesize that pre-radiation HoLEP may decrease their
 overall LUTS and may decrease their need for subsequent radiation therapy. The goal with this
 study is to better understand the overlap between prostate cancer and LUTS, as well as
 determine if primary surgical treatment for the LUTS with HoLEP can also serve as a possible
 treatment modality for concurrent prostate cancer. This information may provide further
 information to inform future standard of care practices for patients with prostate cancer.
Inclusion Criteria:

 -  Patients must be 18 years of age or older

 -  Patients must have bothersome lower urinary tract symptoms (LUTS), defined by American
 Urological Association Symptom Score (AUA SS) of greater than or equal to 15 and/or as
 defined by a post-void residual of greater than or equal to 350mL and/or as defined by
 catheter dependence

 -  Patients must be diagnosed with prostate cancer by pathological tissue analysis

 -  Patients must have elected for radiation with androgen deprivation therapy as the
 primary treatment modality for their prostate cancer

 Exclusion Criteria:

 -  Patients who are under 18 years of age are not eligible

 -  Patients who have a diagnosis of bladder cancer are not eligible.

 -  Patients with prior treatment for prostate cancer are not eligible.

 -  Patients with any type of prior prostate surgery (minimally invasive, endoscopic, or
 otherwise) including prior transurethral resection of the prostate (but excluding
 prior prostate biopsy) are ineligible.

 -  Patients with known metastatic prostate cancer are ineligible

 -  Patients who are enrolled in other surgical or international trials at the time of
 this study are not eligible