Comparison of Cervical Cancer Screening Tests in HIV-infected Women in Lusaka, Zambia
Comparison of Cervical Cancer Screening Tests in HIV-infected Women in Lusaka, Zambia
This study will compare the test performance characteristics of visual inspection with acetic
 acid (VIA), Xpert HPV, and OncoE6 in HIV-infected women, to inform the possible inclusion of
 these molecular tests in future cervical cancer screening
This is a cross-sectional study taking place at cervical cancer prevention clinics in Lusaka,
 Zambia to determine the test performance characteristics (sensitivity, specificity, positive
 predictive value, and negative predictive value) of (1) visual inspection with acetic acid,
 (2) Xpert HPV, and (3) OncoE6 for the detection of CIN2+ among HIV-infected women. All
 cervical screening tests will be evaluated against a gold standard of histopathology obtained
 from cervical biopsies.
Inclusion Criteria:

 -  Women 18 years and older.

 -  Women with documented HIV-infection in their medical record or by on-site testing
 through voluntary counseling and testing.

 -  Women willing to undergo pelvic examination and cervical cancer screening.

 -  Women willing to provide written, informed consent.

 Exclusion Criteria:

 -  Pregnancy