Effect of Obstructive Sleep Apnea Syndrome on Insulin Sensitivity and Cardiovascular Risk in PCOS Adolescents
Effect of Obstructive Sleep Apnea Syndrome on Insulin Sensitivity and Cardiovascular Risk in PCOS Adolescents
Polycystic ovary syndrome (PCOS) is one of the most common disease caused by hormonal
 imbalance and is also associated with overweight and obesity. It affects 5-10% of adolescent
 girls and women capable of having children. Polycystic ovary syndrome is associated with
 missed menstrual periods, hormonal imbalance, being overweight, and with a form of diabetes.
 Girls with polycystic ovary syndrome may have a breathing problem known as "sleep apnea."
 Sleep apnea may cause a person to stop breathing for short periods of time while sleeping.
 People with polycystic ovary syndrome are thirty times more likely to develop sleep apnea
 than those who do not have PCOS. If sleep apnea is not treated, it may lead to daytime
 sleepiness, poor school performance, high blood pressure, heart disease and diabetes. The
 purpose of this study is to understand how insulin function is affected in presence of sleep
 apnea in girls with polycystic ovary syndrome between 13-21 years of age as compared to girls
 with PCOS without sleep apnea. Insulin is one of the hormones made in your body to convert
 food into energy. In people with increase weight body cannot use insulin properly. The
 investigators also want to see if insulin action is also affected by sleep apnea.
See above.
Inclusion Criteria:

 -  Female.

 -  Ages 13-21

 -  PCOS

 -  BMI >95%ile (Obese group) or <85%ile (Lean group)

 -  Controls: ages 18-21, regular menses, BMI <85%ile

 Exclusion Criteria:

 -  Breastfeeding.

 -  Pregnant.

 -  Use of any steroid preparations (including hormonal contraception), medications known
 to alter insulin secretion and/or action within 3 month (including Metformin)