Early Diagnosis of Neonatal Sepsis
Early Diagnosis of Neonatal Sepsis
Sepsis is defined as a systemic inflammatory response syndrome (SIRS) associated with
 infection diagnosed either on microbiologic cultures or strong clinical evidence of an
 infection.
Sepsis is defined as a systemic inflammatory response syndrome (SIRS) associated with
 infection diagnosed either on microbiologic cultures or strong clinical evidence of an
 infection..Worldwide, neonatal sepsis is responsible for 4 million deaths annually and 99% of
 them occur in developing countries.. . morbidity associated with sepsis includes
 sensorineural hearing loss, visual disturbances, seizures, and neurodevelopmental issues..
 Blood culture is considered as gold standard for diagnosis of sepsis. The ideal diagnostic
 test should be inexpensive, have quick results Hematologic scoring system(HSS) of Rodwell et
 al. includes the following: a) White blood cell and platelet count b) White blood
 differential count c) Nucleated red blood cell count (to correct WBC count) d) Assessment of
 neutrophil morphology for degenerative changes. A modified HSS(modified hematological scoring
 system) was developed by removing the repetitive parameters, adding a new parameter -
 nucleated RBC.
Inclusion Criteria:

 -  Newborns with history of prolonged rupture of membranes, maternal intrapartum fever or
 non specific signs of sepsis namely; neonatal fever or hypothermia , poor feeding
 ,lethargy, irritability, depressed neonatal reflexes ,respiratory distress including
 apnea or cyanosis,hypoxia,poor capillary
 perfusion,bradycardia,hypotension,pallor,edema,vomiting,diarrhea,abdominal distention,
 bulging anterior fontanelle,coma,seizures,unexplained jaundice, reduced suckling,
 bleeding problems,hypoglycemia,hyperglycemia or metabolic acidosis were included in
 the study

 Exclusion Criteria:

 -  All the newborn babies with history of delayed cry, meconium aspiration, congenital
 anomaly, history of antibiotics administration prior to admission to the baby or
 mother, intrapartum and neonatal death in sibling with similar presentation will be
 excluded