Ekvasis of Atorvastatin (Antorcin®) Treatment in Patients With Acute Cardiovascular Events
Ekvasis of Atorvastatin (Antorcin®) Treatment in Patients With Acute Cardiovascular Events
In western societies hypercholesterolemia is one of the major and independent factors that
 predispose to cardiovascular disease and death from them. According to the clinical study
 ATTICA, conducted during the years 2001-2002, in which randomized 1514 men and 1528 women,
 rates of hypercholesterolemia observed in a sample of urban population was 39% for men and
 37% women . The prevalence in the corresponding U.S. epidemiological study NIANES was 52% for
 men and 49% women. The relationship between cholesterol, lipid-lowering therapy and risk of
 cardiovascular disease appears to be quite clear in the secondary prevention trials, the 4S
 (Scandinavian Simvastatin Survival Study), CARE (Cholesterol And Recurrent Events) and LIPID
 (Long-term Intervention with Pravastatin in Ischemic Disease) which showed the benefits of
 lowering LDL cholesterol in patients with coronary artery disease. Despite these remarkable
 results, studies were secondary prevention as a major shortcoming, the lack of patients with
 acute coronary events. This gap came to cover the study MIRACL (Myocardial Ischemia Reduction
 with Aggressive Cholesterol Lowering). In MIRACL study , atorvastatin 80 mg was evaluated in
 3,086 patients (atorvastatin n = 1.538, placebo n = 1.548), acute coronary syndrome
 (myocardial infarction without Q-wave or unstable angina). Treatment was initiated during the
 acute phase after hospital admission and lasted for a period of 16 weeks. Treatment with
 atorvastatin 80 mg / day increased the latency of the combined primary endpoint, defined as
 death from any cause, nonfatal myocardial infarction, resuscitated cardiac arrest, or angina
 with objective evidence of myocardial ischemia requiring admission to hospital, indicating a
 risk reduction of 16% (p = 0,048). This was mainly due to a 26% reduction in
 re-hospitalization for angina with objective evidence of myocardial ischemia. The other
 secondary endpoints were not statistically significant by themselves (total: placebo: 22.2%,
 Atorvastatin: 22.4%).

 Statins by reducing coronary syndromes, it appears that contribute to reducing the incidence
 of cardiovascular diseases. This is exactly what was observed in 4S, in which the incidence
 of chronic heart failure (CHF) during follow-up was 10.3% for those who received placebo and
 8.3% in the simvastatin group, a finding which translates 19% reduction in heart failure (P
 <0,015) nationwide with the appearance episode (event) CV.
Determination of cardiovascular risk

 If the assessment of cardiovascular risk remains incomplete, can identify indicators that
 measure risk:

 1. Framingham Risk Score: Includes age, sex, total and HDL-CHOL, and levels of blood
 pressure (can underestimate the risk in some patients).

 2. PROCAM Risk Score: also includes triglycerides, fasting glucose tolerance and family
 history.

 3. Reynolds Risk Score: Includes family history and levels of hsCRP.

 4. Greek Score (www.hearts.org / greece). People with low risk The Framingham Risk Score
 shows <10% chance of cardiovascular disease over the next 10 years. Dealing mainly with
 healthy dietary intervention or drugs when the levels of LDL-CHOL> 190 mg / dL or
 atherogenic index (T-CHOL/HDL-CHOL)> 6.

 Medication is necessary in individuals with familial hypercholesterolemia to reduce the LDL
 CHOL <100 mg / dL. For this reason, a careful family history taking physical examination. The
 Reynolds Risk Score may reclassify their low-risk patients at higher risk individuals.

 Persons moderate risk This group includes mostly middle-aged people. The Framingham Risk
 Score shows 10-19% chance of cardiovascular disease over the next 10 years. However, a
 positive family history and high hsCRP (if available) can modify the level of risk. These
 people need to change my lifestyle for 3 months, but may then be necessary pharmacological
 lipid-lowering therapy in people with at least two major risk factors and levels of LDL-CHOL>
 130 mg / dL. The administration of lipid-lowering therapy in people with levels of LDL-CHOL
 100-129 mg / dL is recommended for people with multiple cardiometabolic risk factors
 (visceral obesity, prediabetes, hypertension, etc.). The increase of atheromatic index (> 5)
 and the presence of high (> 2 mg / L) levels of CRP (if available) are also indications for
 lipid lowering regardless of the levels of LDL-CHOL.

 Major risk factors: age> 45 years (men),> 55 years (women), positive family history of
 premature cardiovascular disease [in the presence of major vascular events in first degree
 relatives <55 years (men), <65 years (women)], hypertension , HDL-CHOL <40 mg / dL, smoking.

 Individuals at high risk The Framingham Risk Score shows> 20% chance of cardiovascular
 disease over the next 10 years. At-risk individuals include:

 A. Individuals with documented atherosclerotic disease (coronary artery disease, stroke, a
 significant degree of carotid stenosis, peripheral arterial disease, intermittent
 claudication, or aneurysm of the abdominal aorta).

 B. All type II diabetic patients and patients with type I diabetes individuals older than 40
 years.

 C. People with chronic kidney disease with glomerular filtration (GFR) <60 mL/min/1, 73 m2.

 In these individuals need intensive lifestyle modification and direct administration lipid
 lowering medication such as statins.

 According to the above that one epidemiological study nature that has the purpose of
 observing and recording the progress of patients after their exit from a cardiology clinic or
 hospital unit because the acid after a cardiovascular event has clinical relevance.
 Compliance with medical instructions, achieving treatment goals for lipids by the addition of
 atorvastatin and personalized medicine practice are open field study. So this will be the
 subject of this study in order to highlight the clinical significance of atorvastatin in
 achieving the objectives of lipids (mainly LDL-CHOL) in blood plasma of "sensitive" of this
 group of patients in the Greek population, as possible representative (qualitatively and
 quantitatively)sample.

 Dyslipidemia

 The lipids of the human body is cholesterol (useful for the synthesis of cell membranes,
 hormones adrenal and gonads, and is a component of bile, the liver secretes) and
 triglycerides (serve as fuel and energy storage in adipose tissue ). The dyslipidemias are
 disorders (quantitative or qualitative) of the metabolism of lipoprotein particles (LDL,
 chylomicrons, HDL, VLDL) that transport lipids in the body.

 Categories dyslipidemias - Primary dyslipidemias

 The most significant primary lipid disorders are:

 1. Chylomicronemia (congenital or acquired): ↑ TRG → risk of acute pancreatitis.

 2. Familial Hypercholesterolemia a Homozygous (1/1.000.000 people): ↑ LDL CHOL b
 heterozygous (1/500 people): ↑ LDL CHOL.

 3. Mixed hyperlipidaemia Familial mixed (1/300 people): ↑ LDL-CHOL, ↑ TRG, ↓ HDL-CHOL.

 4. Familial hypertriglyceridemia (1/2.000 people): ↑ TRG.

 5. Familial decrease in HDL CHOL: ↓ HDL CHOL. Typically in patients with primary
 dyslipidemia needed medication. - Secondary dyslipidemias

 In patients with abnormal lipid parameters of must exclude secondary dyslipidemias, ie
 disorders of lipid metabolism caused by diseases or drugs:

 1. Diabetes

 2. Hypothyroidism

 3. Obstructive liver disease

 4. Chronic kidney disease nephrotic syndrome-

 5. Obesity

 6. Alcohol abuse

 7. Medications that cause dyslipidemia a progestin b Anabolic Steroids c Corticosteroids D.
 Diuretics in large doses e b-blockers f Antiretroviral Drugs Interferon g h. Retinoids
 Estrogen i tamoxifen. In patients with secondary dyslipidemia required treatment of
 primary disease. Determination cohort for screening (Table 1)

 -  Men over 40 and post-menopausal women

 -  People with atherosclerotic disease regardless of age or clinical findings
 suggestive of dyslipidemia

 -  Patients with diabetes regardless of age

 -  Patients with chronic kidney disease (eGFR <60 mL/min/1, 73 m2 or the presence of
 albuminuria)

 -  People with a family history of premature coronary heart disease

 -  People with hypertension

 -  People with chronic inflammatory diseases (lupus erythematosus, rheumatoid
 arthritis, psoriasis or acquired immunodeficiency syndrome)

 -  Adults who smoke

 -  adult with sexual dysfunction

 -  Overweight and obese subjects with BMI> 27 kg/m2

 -  Relatives of people with inherited lipid disorders

 -  Children with a family history of hyperlipidemia or cardiovascular disease or other
 risk factors.

 Statins - Atorvastatin

 The cornerstone of treatment of dyslipidemia are statins.

 Before initiation of lipid lowering requires the identification of lipid parameters {total
 cholesterol, triglycerides, HDL cholesterol and calculated LDL cholesterol [from the equation
 LDL-CHOL = total cholesterol - (triglycerides / 5 + HDL cholesterol)]} after fasting 12 - 14
 hours, while the determination of glucose levels of TSH (to exclude underlying
 hypothyroidism) and transaminases (AST / ALT) and CPK to control the undesirable effects.
 Repeat determination of these parameters in patients who achieved their goals of treatment 2
 times a year or when changing the therapeutic regimen. Repeat laboratory tests (lipid control
 effectiveness and liver enzymes and CPK for security control) after 12 weeks: a reason to
 discontinue treatment if ALT> 3 times the upper normal range or CPK> 5 times the upper normal
 range or in patients with myalgias. It should be noted that not necessitate interruption of
 treatment with statins or deferral of treatment in individuals with small increases in
 transaminases or CPK, while in these patients should be seeking other underlying causes of
 elevated liver and muscle enzymes. The choice of drug and dosage depend on the percentage
 change in HDL-CHOL necessary to achieve the objectives. Statins are usually the evening
 before bedtime the night. The lipid-lowering therapy is therapy for life, and most
 importantly, the patient adherence to treatment. It should be noted that doubling the dose of
 a statin results in additional reduction of HDL-CHOL (LDL) cholesterol by 6%.

 The main goal of treatment is to reduce HDL-CHOL

 The non HDL-CHOL (= T-CHOL - HDL-CHOL), proposed as a secondary target of lipid lowering
 mainly in people with high triglycerides. The target for the non HDL-CHOL is 30 mg / dL
 higher than the target for the HDL-CHOL. The decrease in triglycerides (<150 mg / dL) and
 increased HDL-CHOL (> 40 mg / dL for men and> 50 mg / dL for women) is considered desirable
 targets mainly lipid lowering in diabetic patients and in patients with cardiometabolic risk
 factors. Has also been suggested as a target of treatment to reduce the atheromatous index
 (T-CHOL/HDL-CHOL <4).

 Atorvastatin is indicated as an adjunct to diet to reduce elevated total cholesterol,
 LDL-cholesterol, apolipoprotein B and triglycerides in adults, adolescents and children aged
 10 years and older with primary hypercholesterolaemia, including heterozygous familial
 hypercholesterolaemia combined (mixed) hyperlipidemia (type IIa and IIv by Fredrickson), when
 response to diet and other nonpharmacological measures is inadequate.

 Atorvastatin is also indicated to reduce total cholesterol and LDL - cholesterol in adults
 with homozygous familial hypercholesterolemia as an adjunct to other lipid-lowering
 treatments (eg LDL apheresis) or if such treatments are unavailable.

 Is also used to prevent cardiovascular events in adult patients who are thought to have a
 high risk for a first cardiovascular event, as an adjunct to correction of other risk
 factors.

 Atorvastatin is a selective, competitive inhibitor of HMG-CoA reductase, the enzyme
 responsible for the conversion of 3-hydroxy-3-methyl-glutaryl-coenzyme A to mevalonate, a
 precursor of sterols, including cholesterol. The triglycerides and cholesterol in the liver
 are incorporated into very low density lipoproteins (VLDL) and released into the plasma for
 delivery to peripheral tissues. The low density lipoprotein (LDL) is formed from VLDL and is
 catabolized primarily through receptor high affinity to LDL (LDL receptor).

 Atorvastatin lowers cholesterol levels and lipoprotein plasma inhibiting HMG-CoA reductase
 and then the biosynthesis of cholesterol in the liver and increase the number of LDL
 receptors on the surface of liver cells which uptake and catabolism of LDL. Atorvastatin
 reduces LDL production and the number of particles of LDL. H atorvastatin causes profound and
 sustained increase of LDL receptor activity, in combination with a beneficial change in the
 quality of the circulating particles of LDL. Atorvastatin effectively reduces LDL-C in
 patients with homozygous familial hypercholesterolemia, a group of patients who do not
 usually respond to lipid-lowering medicines.

 Atorvastatin in a dose-response study, was shown to reduce the concentration of T-CHOL (30% -
 46%), the LDL-CHOL (41% - 61%), apolipoprotein B (34% - 50%) and triglycerides (14% - 33%)
 while producing variable increases HDL-CHOL and apolipoprotein A1. These results are so
 consistent in patients with heterozygous familial hypercholesterolaemia, non-familial forms
 of hypercholesterolemia and mixed hyperlipidemia, including patients with
 noninsulin-dependent diabetes mellitus.

 It has been found that the decrease of the values of total cholesterol, LDL-CHOL and
 apolipoprotein B reduces the risk of cardiovascular events and mortality thereof.
Inclusion Criteria:

 -  Outpatients (External Ambulatory) Patients.

 -  Male or female patients

 -  18 to 99 years

 -  Patients with Hypercholesterolemia

 -  Patients with and without treatment with statin

 -  Patients enrolled in any of the study sites with acute cardiovascular event

 -  Patients discharged with study medication (Antorcin ®)

 -  Patients who have agreed and signed the consent form for the recording and processing
 of their personal data.

 Exclusion Criteria:

 -  Patients under 18 and over 99 years.

 -  Women in pregnancy or lactation period

 -  Patients enrolled in any of the study sites for any reason other than an acute
 cardiovascular event

 -  Patients who discharged and take another statin drug formulation other than the study
 drug formulation (Antorcin ®)

 -  Patients who have not consented and signed the consent form for the recording and
 processing of their personal data.