Genetic Basis of Mitral Valve Prolapse
Genetic Basis of Mitral Valve Prolapse
The investigators have successfully identified two novel genetic loci for MVP on chromosomes
 11 and 13 and are searching for altered genes in these regions. This requires recruiting
 large families who may have MVP linked to these or other chromosomes; and obtaining DNA
 samples from 1,000-1,500 individually affected patients to study the relation between DNA
 markers throughout the genome and MVP. It is our expectation that the results of this study
 will lead to the discovery of gene(s) responsible for MVP. This will lead to improved
 understanding of the disease and, in turn, improved ability to treat and prevent progression
 in genetically susceptible individuals.
This is a genome-wide association study.
Inclusion Criteria:

 -  Mitral valve prolapse

 Exclusion Criteria:

 -  Other mitral valve diseases