Evaluation of Efficacy of Ophthalmic Solution in Induced Allergic Conjunctivitis
Evaluation of Efficacy of Ophthalmic Solution in Induced Allergic Conjunctivitis
The purpose of this study is to establish the efficacy of R89674 0.25% ophthalmic solution
 compared with placebo in alleviating the signs and symptoms of conjunctival allergen
 challenge-induced allergic conjunctivitis
Inclusion Criteria:

 history of ocular allergies and a positive skin test reaction to cat hair, cat dander,
 grasses, ragweed, and/or trees within the past 24 months; calculated best-corrected visual
 acuity of 0.6 logMar or better in each eye; positive bilateral conjunctival allergy
 challenge reaction

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 Exclusion Criteria:

 narrow angle glaucoma, clinically significant blepharitis, follicular conjunctivitis,
 iritis, pterygium or diagnosis of dry eye; ocular surgical intervention within 3 months;
 history of refractive surgery within 6 months; known history of retinal detachment,
 diabetic retinopathy, or progressive retinal disease; presence of active ocular infection
 positive history of an ocular herpetic infection; preauricular lymphadenopath; manifest
 signs or symptoms of clinically active allergic conjunctivitis