Evaluation of the Antihypertensive Effect of Hyzaar(R) and Cognitive Function of Hypertensive Patients (0954A-322)
Evaluation of the Antihypertensive Effect of Hyzaar(R) and Cognitive Function of Hypertensive Patients (0954A-322)
Evaluate the antihypertensive and neuroprotective effects of Hyzaar(R) in elderly subjects in
 comparison with Natrilix(TM).
Inclusion Criteria:

 -  ACEi or ARB naive or not taking ACEi or ARB concurrently for at least one month before
 the run-in period

 -  Be able to carry out his or her own daily activity

 -  - Be at least 50 years old at inclusion in the study Be diagnosed with mild to
 moderate hypertension, treated or untreated

 -  Literate

 -  Not taking any cognitive-enhanced agent at baseline

 -  Present with a memory complain ( spontaneous or informed by caregiver)

 Exclusion Criteria:

 -  Congestive heart failure with NYHA class >2

 -  Renal failure or renal insufficiency with serum creatinine >1.4mg/dl

 -  chronic severe liver disease with abnormal GPT and GOT >2 times of upper normal limits

 -  Diagnosed with major depression when entering the study

 -  Foreign language as his or her mother tongue so that the test results will not be
 reliable

 -  History of stroke or transient ischemic attack (stroke is defined as focal
 neurological sign progressing stepwise)

 -  Hypersensitive to the active ingredient and any other component of losartan potassium
 and indapamide tablets

 -  Major hearing loss/deafness and/or major visual impairment/blindness preventing from
 performing the tests

 -  Myocardial infarction within the past 6 months

 -  Single functioning kidney

 -  Anuria