Clonal Mast Cell Disorders in Exercise-Induced Anaphylaxis
Clonal Mast Cell Disorders in Exercise-Induced Anaphylaxis
Anaphylaxis is a serious allergic reaction that develops rapidly and can cause death. Some
 patients experience anaphylaxis is association with exercise, a disorder called
 exercise-induced anaphylaxis. A subset of patients with unexplained anaphylaxis, especially
 those with hypotension during the anaphylactic episodes, have been shown to have abnormal,
 clonal populations of a certain cell type, mast cells, in the bone marrow. This has been
 described in at least one patient with exercise-induced anaphylaxis. The investigators would
 like review the findings in a group of patients with exercise-induced anaphylaxis who have
 undergone evaluation for the presence of abnormal, clonal mast cells.
Inclusion Criteria:

 -  Anaphylaxis in association with exercise on at least two occasions

 -  During anaphylactic reaction, the subject must have experienced one or more of the
 following: flushing, hypotension, lack of urticaria

 Exclusion Criteria:

 -  Pregnancy