Acute Effects of Cinacalcet on Arterial Stiffness and Ventricular Function in Hemodialysis Patients
Acute Effects of Cinacalcet on Arterial Stiffness and Ventricular Function in Hemodialysis Patients
The primary objective is to determine whether reduction of serum calcium concentration by
 cinacalcet leads to reduction of mean blood pressure adjusted c-fPWV. The secondary
 objectives are to study the effects of calcium reduction on 1) carotid-radial PWV (c-rPWV),
 2) common carotid artery (CCA) biomechanics, 3) pulse wave profile and cardiac function.
Inclusion Criteria:

 -  chronic (> 3 months) hemodialysis population of > 18 years old

 -  PTH > 300 ng/L

 -  corrected Ca > 2.10 mmol/L

 -  stable hypertensive drugs (> 1 month)

 -  stable doses of phosphate binders and dialysis calcium concentration

 -  palpable femoral pulse

 -  systolic BP of 90-180 mmHg

 -  expected survival of > 6 months

 Exclusion Criteria:

 -  hemodialysis > 3 years

 -  acute infection

 -  history of myocardial infarction or stroke within the past 3 months

 -  inability to consent

 -  intolerance to cinacalcet

 -  inadequate birth control