Impact of Chemotherapy and Regenerative Markers of Liver Regeneration After Liver Resection for Liver Metastases
Impact of Chemotherapy and Regenerative Markers of Liver Regeneration After Liver Resection for Liver Metastases
Liver is special organ, which can regenerate. On that ability there are many treatment
 modalities, where liver resection is performed, especially in cancer patients with liver
 metastases. Liver regeneration provides an opportunity for these patients to undergo multiple
 treatment regimes and liver resections to achieve curability. There are many factors that
 impair liver regeneration. One of these factors is chemotherapy. Literature data on impact of
 chemotherapy to liver regeneration is ambiguous. Therefore we aim to research impact of
 chemotherapy to liver regeneration.
Liver is the largest parenchymal organ responsible for over 500 different functions in human
 body, which are detoxification of various toxins, drugs, synthesis of proteins and enzymes,
 coagulation factors. Liver is special organ, which can regenerate. If 75% of liver is removed
 it can regenerate to its normal size. Liver volume is very important to liver function, if
 there is volume insufficiency it could lead to liver failure in addition to other factors
 that impair liver regeneration. On that regenerative ability there are many treatment
 modalities, when liver resection is performed, especially in cancer patients with liver
 metastases. Modern treatment modalities are based on combination of different treatments,
 surgical and chemotherapeutic. On the other hand, side effects of chemotherapy should not be
 discarded, which can increase patient morbidity and mortality. Thus, liver regeneration
 provides an opportunity for these patients to undergo multiple treatment regimes and liver
 resections to achieve curability. Literature data on impact of chemotherapy to liver
 regeneration is ambiguous. Therefore we aim to research impact of chemotherapy to liver
 regeneration.
Inclusion Criteria:

 • Patients with liver lesions, who are eligible for liver resection

 Exclusion Criteria:

 -  Pregnant women

 -  Liver resection is not performed