Epidemiology Study on Insulin-like Growth Factor-1 in Children With Idiopathic Short Stature (EPIGROW Study)
Epidemiology Study on Insulin-like Growth Factor-1 in Children With Idiopathic Short Stature (EPIGROW Study)
The purpose of the protocol is to describe the distribution of IGF-1 deficiency in the
 studied population of Idiopathic Short Children without Growth Hormone Deficiency or any
 other identified cause of short stature and not treated with recombinant Growth Hormone or
 IGF-1
Inclusion Criteria:

 -  Short children, height ≤ -2.5 SDS

 -  Age ≥ 2 years

 -  With at least one normal or elevated peak GH response to a stimulatory test (peak GH ≥
 7 ng/mL) at the time of the study and/or at a given time-point during the last 12
 months

 -  Pre-pubertal

 -  Signed Informed Consent, including agreement to have blood samples taken for hormonal
 measurement and genetic analysis, by both parents or by Legally Acceptable
 Representatives when applicable and the child when applicable

 Exclusion Criteria:

 -  The following identified causes of short stature:

 -  GH-deficient short stature

 -  Other endocrine causes (hypothyroidism, Cushing's syndrome, parathyroid or vitamin D
 disorders, hypogonadism)

 -  Identified syndromes with genetic abnormalities (including Turner, Noonan and
 Russell-Silver syndromes)

 -  Chronic diseases including malnutrition, coeliac disease, chronic inflammation,
 muscular dystrophy, thalassaemia, blood disorders, severe liver or kidney disease and
 severe cyanotic heart disease

 -  Chronic diseases requiring treatment with chronically administered corticosteroids

 -  Skeletal dysplasia

 -  Psychosocial short stature

 -  Patients having received irradiation, including total body irradiation

 -  Patients currently on GH or IGF-1 therapy or having received GH or IGF-1 therapy in
 the last 12 months

 -  Patients likely to require GH, IGF-1 or chronic corticosteroid treatment during the
 study

 -  Any mental condition that prevents both parents or Legally Acceptable Representatives
 and the child when applicable from understanding the nature, scope and possible
 consequences of the study, or any evidence of an uncooperative attitude