Ipilimumab and Nivolumab in Recurrent Extensive Stage Small Cell Lung Cancer After Receiving Platinum-based Chemotherapy
Ipilimumab and Nivolumab in Recurrent Extensive Stage Small Cell Lung Cancer After Receiving Platinum-based Chemotherapy
This is a pilot study of patients who previously received platinum chemotherapy with
 recurrent SCLC to evaluate the change in the ratio of intratumoral Teff/Treg cells and
 clinical benefit of treatment with nivolumab and ipilimumab.
The primary objective of this study is t assess whether the change in the ratio of effector T
 cells (Teff) to regulatory T cells (Treg), i.e. CD8 positive/FoxP3 expressing CD4 T cells,
 between pre- and on- treatment biopsies, will predict clinical response in patients with
 recurrent SCLC treated with combination therapy with nivolumab and ipilimumab.

 Secondary objectives of the study include: to determine the objective response rate per
 RECIST 1.1 and immune-related response criteria, duration of response, progression free
 survival, and overall survival with nivolumab and ipilimumab in patients with recurrent SCLC;
 to evaluate changes in the tumor immune microenvironment and blood after treatment with
 ipilimumab and nivolumab; and to evaluate circulating tumor DNA (ctDNA) as a marker for
 response to therapy.
Inclusion:

 -  Patients with an active autoimmune disease requiring systemic treatment within the
 past 3 months, or a syndrome that requires systemic steroids greater than
 dexamethasone 2 mg daily (or equivalent) or immunosuppressive agents within the past 3
 months will be ineligible. Patients with a documented history of severe autoimmune
 disease but have been off of steroids and immunosuppressive agents for greater than 3
 months, or only require intermittent steroid bursts may be eligible following
 discussion and approval from the Principal Investigator. Subjects with vitiligo or
 resolved childhood asthma/atopy would be an exception to this rule. Subjects who
 require intermittent use of inhaled steroids or local steroid injections would not be
 excluded from the study. Subjects with hypothyroidism stable on hormone replacement,
 or psoriasis not requiring systemic therapy (within the past 3 years) or Type 1
 diabetes on stable insulin will not be excluded from the study

 -  Histologically or cytologically documented Extensive Stage Small Cell Lung Cancer with
 documented disease progression after at least one prior systemic regimen, including
 one platinum-based regimen, with progression of disease on or after their most recent
 therapy. Patients previously diagnosed with limited stage Small Cell Lung Cancer
 treated with concurrent chemoradiation with a platinum doublet now diagnosed with
 recurrent extensive disease are eligible.

 -  ECOG performance status of 0 to 2

 -  Measurable disease with at least one tumor site amenable to biopsy

 -  Patients may have untreated asymptomatic Central Nervous System (CNS) metastases or
 treated CNS metastases if they are not currently receiving corticosteroids greater
 than dexamethasone 2 mg daily or equivalent for 7 days prior to the first dose of
 study drug. Patients should have completed stereotactic radiation or whole-brain
 radiation at least 2 weeks prior to Cycle 1, Day 1

 Exclusion:

 -  Patients with an active autoimmune disease requiring systemic treatment within the
 past 3 months or a documented history of clinically severe autoimmune disease, or a
 syndrome that requires systemic steroids > dexamethasone 2 mg daily (or equivalent
 dose of other corticosteroids) or other immunosuppressive agents.

 -  Treatment with systemic immunosuppressive medications including but not limited to,
 dexamethasone at doses > 2 mg or equivalent dose of other corticosteroids,
 cyclophosphamide, tacrolimus, sirolimus, azathioprine, methotrexate, thalidomide, and
 antitumor necrosis factor (anti-TNF) agents within 2 weeks prior to initiation of
 trial therapy. Inhaled or topically applied steroids, and acute and chronic
 standard-dose NSAIDs are permitted. Replacement steroids are also permitted.

 -  Prior treatment with anti-CTLA4 antibodies. Prior anti-PD1 or anti-PDL1 therapy is
 allowed.

 -  Symptomatic untreated CNS metastases. Patients with asymptomatic CNS metastases are
 eligible. Patients with symptomatic brain metastases are eligible, provided they meet
 all of the following criteria:

 -  Completed stereotactic radiosurgery or whole- brain radiation at least 2 weeks
 prior to Cycle 1, Day 1.

 -  No evidence of interim progression between the completion of CNS-directed therapy
 and the start of trial therapy.

 -  No ongoing requirement for steroids greater than dexamethasone 2 mg daily (or
 equivalent dose of other corticosteroids) as therapy for CNS disease;
 anticonvulsants at a stable dose are allowed.

 -  History of leptomeningeal carcinomatosis.

 -  Interstitial lung disease that is symptomatic or may interfere with the detection or
 management of suspected drug-related pulmonary toxicity.

 -  Any systemic anti-cancer chemotherapy, within 21 days prior to initiation of study
 treatment.

 -  Treatment with any other investigational agent or participation in another clinical
 trial with therapeutic intent within 21 days prior to enrollment.

 -  Uncontrolled intercurrent illness including, but not limited to, symptomatic
 congestive heart failure, unstable angina pectoris, or psychiatric illness/social
 situations that would limit compliance with study requirements.

 -  Major surgery or traumatic injury within 4 weeks of starting study drug.

 -  - Women who are pregnant or lactating.

 -  - Known infection with HIV, HBV or HCV. Patients with prior exposure to hepatitis, but
 no evidence of active or chronic infection, may be eligible.

 -  - Evidence of end-organ damage as defined by the following laboratory results obtained
 within 14 days prior to the first study treatment:

 -  ANC <1,000 cells/µL (without granulocyte colony-stimulating factor support within
 2 weeks prior to Cycle 1, Day 1).

 -  Platelet count <75,000/µL (without transfusion within 2 weeks prior to Cycle 1,
 Day 1).

 -  Hemoglobin <8.0 g/dL (Patients may be transfused to meet this criterion).

 -  AST and ALT ≥2.5 x ULN, with the following exceptions: Patients with documented
 liver metastases: AST and/or ALT≥5 x ULN. o Serum bilirubin ≥1.5 x ULN (Patients
 with known Gilbert disease who have serum bilirubin level ≤ 3 x ULN may be
 enrolled).

 -  INR and aPTT ≥1.5 x ULN (This applies only to patients who are not receiving
 therapeutic anticoagulation; patients receiving therapeutic anticoagulation
 should be on a stable dose).