Polymorphisms in Inflammatory Cytokines Genes in Subjects With Obstructive Sleep Apnea
Polymorphisms in Inflammatory Cytokines Genes in Subjects With Obstructive Sleep Apnea
Obstructive sleep apnea is a common sleep disorder. It is known to be related with increased
 body mass, abdominal obesity, insulin resistance and hypertension. It is currently believed
 to be a feature of the metabolic syndrome. Other features of the metabolic syndrome-such as
 insulin resistace were found related to inflammation and inflammatory cytokines. Several
 polymorphisms in the genes that encode interleukin 6,inteleukin 10 and TNF-alpha have
 significant influence on the amounts of cytokine production. we thus hypothesize that
 polymorphisms related to increased pruduction are more common in subjects with OSA than in
 matched controls
Patients attending a sleep apnea clinic for evluation will be recruited. Patients found
 positive for OSA will be compared to the patients with a negative study for OSA for the
 prevalence of polymorphisms in genes of inflammatory cytokines and cytokine levels
Inclusion Criteria:

 -  Patients attending the sleep apnea clinic for evaluation

 Exclusion Criteria:

 -  patients known to have inflammatory conditions