Severe LH Suppressed Patients After Administration of a GnRH Antagonist
Severe LH Suppressed Patients After Administration of a GnRH Antagonist
The ideal stimulation protocol for ovarian stimulation is under constant debate, as we gain
 more pharmacological control over the patient hormonal milieu. Specifically, the debate
 focuses around the ideal LH levels. The concept of an "LH window" was suggested.

 The need for a threshold level of LH is clearly demonstrated in hypogonado-tropic
 hypogonadism patients, but also in cycling patients receiving high doses of GnRH antagonist.
 The Ganirelix dose finding study demonstrated very low implantation rates in the high dose
 groups (1 mg, 2 mg).

 The stimulation dynamics in these patients were remarkable for very low E2 and LH levels on
 the day of hCG. In fact, a functional state of hypogonadotropic hypogonadism is achieved,
 explaining the poor clinical results (1.5% implantation rate under 2 mg Ganirelix). The same
 protocol was repeated with added Luveris resulting in excellent pregnancy rates.

 The recommended daily dose of GnRH antagonist is 0.25 mg which on the average provides a
 protection from premature LH surge, with moderate suppression of LH. Therefore, most patients
 do not need supplemented LH after the antagonist is initiated.

 However, there is a subgroup of patients who hyper-respond to the antagonist (in 0.25 mg
 dose) with a sharp decrease in LH. This explains contradictory findings in the available
 studies. The basic assumption in the background of this proposal is that there is a wide
 range of pituitary responses to GnRH antagonist. Obeying a bell-shape curve, most women have
 an average response, however, some hypo-respond might ovulate prematurely, and others
 hyper-respond. In the latter cases, pituitary response will behave as if exposed to a higher
 dose.

 How to identify an exposure to a presumed higher dose?

 Below is a figure from the original paper. A close look indicates that the immediate response
 to all Ganirelix doses are similar in terms of LH drop, however, the big difference lies in
 the pituitary recovery 24 hours post Ganirelix dose.

 While small doses allow for a quick recovery to almost pre-treatment LH levels, high doses
 result in incomplete recovery. Hence, it is reasonable to speculate that the high response to
 0.25 mg dose will lead to slow or incomplete recovery of LH levels 24 hours post the initial
 dose.

 It is estimated that about 15% of patients are antagonist hyper-responders. Efforts to
 individualize patient protocol must target this group as candidates for supplemented LH. This
 estimate is similar to study findings: Huirne et al Human Reproduction 2005, 20: 359.
Inclusion Criteria:

 -  1. The patient is eligible for IVF and will be treated according to the Summary of
 Product Characteristics (SmPC) and routine practice in participating centres.

 2. The patient must be willing and able to comply with the protocol for the duration
 of the study.

 3. The patient has given written informed consent with the understanding that the
 consent may be withdrawn by her at any time without prejudice for her future medical
 care.

 4. Must be hyper-responder to antagonist according definition

 Exclusion Criteria:

 1. Ovarian, uterine or mammary cancer.

 2. Tumours of the hypothalamus and pituitary gland.

 3. Uterine myoma requiring treatment.

 4. Ovarian enlargement or cyst of unknown aetiology.

 5. A clinically significant systemic disease.

 6. Abnormal gynaecological bleeding of undetermined origin.

 7. Known allergy or hypersensitivity to human gonadotrophin preparations.

 8. Entered previously into this study or simultaneous participation in another clinical
 study.

 9. Age > 39 yrs,

 10. BMI > 32 kg/m2,

 11. Patient with no cycles: PCOS or an anovulatory patient. -