Carboplatin, Paclitaxel, and Bevacizumab With or Without Erlotinib Hydrochloride in Treating Non-Smokers With Advanced Non-Small Cell Lung Cancer
Carboplatin, Paclitaxel, and Bevacizumab With or Without Erlotinib Hydrochloride in Treating Non-Smokers With Advanced Non-Small Cell Lung Cancer
This randomized phase II trial studies how well carboplatin, paclitaxel, and bevacizumab work
 with or without erlotinib hydrochloride in treating non-smokers with advanced non-small cell
 lung cancer. Drugs used in chemotherapy, such as carboplatin and paclitaxel, work in
 different ways to stop the growth of tumor cells, either by killing the cells or by stopping
 them from dividing. Monoclonal antibodies, such as bevacizumab, can block tumor growth in
 different ways. Some block the ability of tumor cells to grow and spread. Others find tumor
 cells and help kill them or carry tumor-killing substances to them. Erlotinib hydrochloride
 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and
 by blocking blood flow to the tumor. It is not yet known whether giving combination
 chemotherapy together with bevacizumab is more effective with or without erlotinib
 hydrochloride in treating patients with non-small cell lung cancer.
PRIMARY OBJECTIVES:

 I. To evaluate the progression-free survival (PFS) of non-smokers with advanced non-small
 cell lung cancer (NSCLC) randomized to standard of care (either carboplatin/paclitaxel with
 or without bevacizumab), or standard of care plus erlotinib hydrochloride.

 SECONDARY OBJECTIVES:

 I. To evaluate the overall survival from day of randomization. II. To evaluate response rate.
 III. To evaluate relative toxicity. IV. To determine the frequency of epidermal growth factor
 receptor (EGFR) and Kras mutations in non-smokers with NSCLC and correlate mutation status
 with response rate and progression free survival.

 V. To obtain blood and tissue specimens for further marker-based exploratory analyses
 regarding EGFR inhibitors.

 VI. To evaluate EGFR positivity by fluorescence in situ hybridization (FISH) as a predictor
 of improved PFS in patients treated with erlotinib hydrochloride.

 OUTLINE: This is a multicenter study. Patients are stratified according to gender and
 eligibility for bevacizumab therapy (ineligible vs eligible and willing to receive
 bevacizumab vs eligible and not willing to receive bevacizumab). Patients are randomized to 1
 of 2 treatment arms.

 ARM I: Patients receive paclitaxel intravenously (IV) over 3 hours and carboplatin IV over 30
 minutes (with or without bevacizumab IV over 30-90 minutes) on day 1. Patients also receive
 placebo orally (PO) once daily (QD) on days 1-21. Treatment repeats every 21 days for 6
 courses in the absence of disease progression or unacceptable toxicity. After completion of 6
 courses, patients with stable or responding disease may continue to receive placebo (with or
 without bevacizumab) as above in the absence of disease progression or unacceptable toxicity.

 ARM II: Patients receive paclitaxel and carboplatin (with or without bevacizumab) as in arm
 I. Patients also receive erlotinib hydrochloride PO QD on days 1-21. Treatment repeats every
 21 days for 6 courses in the absence of disease progression or unacceptable toxicity. After
 completion of 6 courses, patients with stable or responding disease may continue to receive
 erlotinib hydrochloride (with or without bevacizumab) as above in the absence of disease
 progression or unacceptable toxicity.

 Blood and tissue samples are collected for correlative laboratory studies.

 After completion of study treatment, patients are followed up periodically for 5 years.
Inclusion Criteria:

 -  Measurable disease as defined by Response Criteria In Solid Tumors (RECIST) criteria

 -  Baseline measurements and evaluations of all sites of disease must be obtained =< 4
 weeks (28 days) prior to randomization

 -  Eastern Cooperative Oncology Group (ECOG) performance status between 0-1

 -  No prior chemotherapy for lung cancer; prior chemotherapy for an unrelated condition
 is allowed if completed > 3 years prior to date of randomization

 -  Histological or cytologic evidence of non-small cell lung cancer

 -  Patients must not have any additional active, invasive malignancies requiring therapy

 -  Patients must have smoked less than or equal to 100 cigarettes in their lifetime

 -  Stage IV or IIIB (with pleural or pericardial effusion or multifocal pleural
 involvement) or recurrence after prior curative resection or definitive radiation

 -  Prior radiation therapy (RT) is allowed, provided RT has ended at least 2 weeks (14
 days) prior to date of randomization; patients must have recovered from any adverse
 events related to the RT (except alopecia and grade 1 neuropathy); no previous
 irradiation to the only site of measurable disease, unless that site has had
 subsequent evidence of pathologic or radiologic progression

 -  Absolute neutrophil count (ANC) >= 1500/mm^3

 -  Platelet count >= 100,000/mm^3

 -  Bilirubin =< 1.5 mg/dl

 -  Creatinine =< 2.0 mg/dl

 -  Serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvate
 transaminase (SGPT) =< 3 X institutional upper limit of normal (ULN)

 -  Women must not be pregnant or breast-feeding due to unknown interaction between
 erlotinib and the developing fetus or newborns potentially exposed to erlotinib by
 ingestion of lactated milk; all females of childbearing potential must have a blood
 test within 2 weeks prior to randomization to rule out pregnancy

 -  Women of childbearing potential and sexually active males must be strongly advised to
 use an accepted and effective method of contraception

 -  Patients must not have clinically significant ongoing or active infection, symptomatic
 congestive heart failure, unstable angina pectoris, symptomatic or uncontrolled
 cardiac arrhythmia, or psychiatric illness/social situations that would limit
 compliance with study requirements

 -  Patient must meet the following criteria:

 -  Non-squamous histology

 -  No antecedent hemoptysis

 -  International normalized ratio (INR) =< 3 within 4 weeks (28 days) prior to
 randomization

 -  Patients may be on a stable regimen of therapeutic anticoagulation or may be receiving
 prophylactic anticoagulation of venous access devices, provided that coagulation
 studies met entry criteria; caution must be exercised for patients requiring
 anticoagulation, including treatment with low dose heparin or low molecular weight
 heparin for deep vein thrombosis (DVT) prophylaxis while on study due to an increased
 risk of bleeding with bevacizumab

 -  No history of untreated brain metastases NOTE: Recent data (PASSPORT, ATLAS, AIRES)
 suggest that bevacizumab can be given in patients with treated brain metastases;
 investigators can use their discretion in deciding whether to use bevacizumab in
 patients who fulfill these criteria

 -  Urine dipstick must be =< 0-1+ within 4 weeks (28 days) of randomization. If urine
 dipstick is > 1+ then the Urine Protein Creatinine (UPC) ratio must be calculated

 -  Patients must have no history of thrombotic or hemorrhagic disorders

 -  Patients with history of hypertension must be well-controlled (blood pressure [BP] =<
 150/90 within 4 weeks [28 days] of randomization) and on a stable regimen of
 anti-hypertensive therapy (within 4 weeks of randomization)

 -  Patients must not have serious non-healing wound ulcer, bone fracture, or major
 surgical procedure within 28 days prior to randomization

 -  Patients with a known history of myocardial infarction or other evidence of arterial
 thrombotic disease (angina) will be allowed on study only if they have had no evidence
 of active disease for at least 6 months prior to randomization

 -  Patients must not have a history of abdominal fistula, gastrointestinal perforation or
 intra-abdominal abscess within 6 months prior to randomization

 -  Patients must not have significant vascular disease (e.g., aortic aneurysm, requiring
 surgical repair or recent peripheral arterial thrombosis) within 6 months prior to
 randomization

 -  Patients must not have clinically significant cardiovascular disease including:

 -  History of cerebral vascular accident (CVA) within 6 months

 -  New York Heart Association grade II or greater congestive heart failure

 -  Serious and inadequately controlled cardiac arrhythmia

 -  Clinically significant peripheral vascular disease (symptomatic with intermittent
 claudications or < 6 months from a bypass operation)