Cobalamin Status in Young Children With Developmental Delay
Cobalamin Status in Young Children With Developmental Delay
During fetal life and infancy, an adequate cobalamin status is important for normal growth
 and central nervous system development. During the last years we have detected cobalamin
 deficiency in a number of infants admitted to the Pediatric Department with various symptoms,
 including neurological symptoms and feeding problems. Cobalamin treatment is given to the
 infants with biochemical cobalamin deficiency, and leads to loss of symptoms and in improved
 physical condition.

 In this study we want to establish the prevalence of cobalamin deficiency in infants with
 developmental delay and regression and other vague neurological symptoms. Cobalamin status
 will be investigated in all children aged 8 months and younger, admitted to the Pediatric
 Department with these symptoms. In a randomised intervention trial we will evaluate the
 effect of cobalamin supplementation in children with these symptoms and metabolic evidence of
 impaired cobalamin status.

 Study hypothesis: Cobalamin treatment given to the infants with biochemical cobalamin
 deficiency, will lead to loss of symptoms and in improved physical condition.
Inclusion Criteria:

 -  Children below 8 months of age

 -  Clinical diagnosis or symptoms: developmental delay and regression and other vague
 neurological symptoms

 Exclusion Criteria:

 -  Children with syndromic disease