Glycemic Fluctuations in Newly Diagnosed Growth Hormone-Secreting Pituitary Adenoma and Cushing Syndrome Subjects
Glycemic Fluctuations in Newly Diagnosed Growth Hormone-Secreting Pituitary Adenoma and Cushing Syndrome Subjects
Glucose fluctuations present not only in patients with diabetes mellitus but also in subjects
 with normal glucose tolerance or impaired glucose regulation. People with Growth
 Hormone-Secreting Pituitary Adenoma and Cushing Syndrome are at risk of impaired glucose
 metabolism. Glycemic variability is poorly studied in the nondiabetic individuals. The aim of
 the study is to investigate the characteristics of glucose fluctuations in the newly
 diagnosed Growth Hormone-Secreting Pituitary Adenoma and Cushing Syndrome individuals.
Glucose fluctuations present not only in patients with diabetes mellitus but also in subjects
 with normal glucose tolerance or impaired glucose regulation. Compared with traditional
 monitoring methods, continuous glucose monitoring system(CGMS) techniques provides a much
 more detailed understanding of shifting blood glucose levels throughout the day.It is
 considered reliable to evaluate glucose variability not only in patients with diabetes but
 also in nondiabetic individuals.

 People with Growth Hormone-Secreting Pituitary Adenoma and Cushing Syndrome are at risk of
 impaired glucose metabolism and developing diabetes mellitus.Some researchers have shown that
 15-30% Growth Hormone-Secreting Pituitary Adenoma are suffering from diabetes, 15-36%
 impaired glucose regulation. The rate of Cushing Syndrome individuals is 10-30% and 40-45%
 separately.

 Glycemic variability is poorly studied in the nondiabetic individuals and has not been
 studied in the newly diagnosed Growth Hormone-Secreting Pituitary Adenoma and Cushing
 Syndrome individuals. In this study CGM was used to dynamically monitor patients being newly
 diagnosed with Growth Hormone-Secreting Pituitary Adenoma and Cushing Syndrome.
Inclusion Criteria:

 -  •newly diagnosed GH-releasing pituitary adenoma

 -  •newly diagnosed Cushing Syndrome

 Exclusion Criteria:

 -  •history of diabetes mellitus and being treated with drugs

 -  •being treated with drugs which affect glucose metabolism in the lately 3 months

 -  •with other hormones affecting glucose metabolism secreted abnormally by pituitary

 -  •serious comorbidity like malignant tumour, severe hepatosis or nephropathy, serious
 hypertension(blood pressure> 180/110mmhg)

 -  •pregnant or breastfeeding women

 -  •patients allergic to patches or metal