Comparison of BMD Measurement by DEXA to BeamMed Speed-of-Sound Measurement at Forearm in Patients With Gaucher Disease
Comparison of BMD Measurement by DEXA to BeamMed Speed-of-Sound Measurement at Forearm in Patients With Gaucher Disease
The purpose of this study is to compare the accuracy and comparability and secondarily to
 assess the values achieved by measurement of the forearm BMD by DXA and SOS by BeamMed,
 relative to standard DXA evaluations at the FN and LS.
Dual-energy X-ray absorptiometry (DXA) is the current gold standard for the clinical
 diagnosis of osteoporosis based on measurement of bone mineral density (BMD) [Baim et al,
 2006]. As DXA technology continues to evolve, new instruments and technologies are introduced
 [Shepherd et al, 2005], making it necessary to document how these advances compare to prior
 densitometers.

 The purpose of this study is to assess bone mineral density (BMD) comparability and precision
 using a standard Hologic DXA unit and the quantitative ultrasound-driven speed-of-sound (SOS)
 BeamMed technology. The physical and mechanical properties of bone that are measured by SOS
 are different than bone density measured by DXA and reflect bone strength and elasticity
 [Goossens et al, 2008]. The cohorts will be patients with Gaucher disease [Zimran & Elstein,
 2010] who currently are requested to undergo BMD evaluation only bi-annually [Mistry et al,
 2011], partly because of the radiation of DXA scans (admittedly low relative to standard
 X-rays and CT). Patients with Gaucher disease are at added risk for osteonecrosis and
 pathological fractures but to date no biomarker or technology has been able to predict which
 patients are imminently at risk. Because the option of disease-specific but very costly
 enzyme replacement therapy (ERT) [Barton et al, 1991] is predicating on the estimated risk of
 severe disease, predicting skeletal damage (especially osteonecrosis at the femoral neck, FN)
 because of osteopenia or osteoporosis has clinically relevant ramifications [Mistry et al,
 2011]. Additionally, it has been shown that there is a correlation between low BMD at the
 lumbar spine (LS) and anemia in patients with Gaucher disease [Khan et al, 2012], so that
 with correction of anemia with ERT it is hoped that there will be amelioration of BMD values,
 and this too would be worth performing at closer intervals.

 The least inconvenient and shortest evaluation for BMD is at the forearm. For approximately a
 year, all patients at the Gaucher disease have had DXA forearm evaluations when undergoing
 routine testing. It is the intention of this study to prospectively compare forearm SOS
 results [Olszynski et al, 2013] with those from the standard DXA equipment with the
 possibility of using SOS as a quantitative measure of bone integrity on a more regular basis.

 The strategy will be to measure forearm BMD by DXA and SOS by BeamMed for comparison of
 accuracy and comparability and secondarily to assess the values achieved at the forearm
 relative to standard DXA evaluations at the FN and LS.

 Patients who arrive at the Gaucher Clinic for routine monitoring that includes DXA evaluation
 of BMD at FN, LS, and forearm will be requested to consent to undergo SunBeam evaluation at
 the forearm as well. The same DXA hardware and software (Hologic, Bedford, MA) will be used
 for all examinations as have been employed by the Gaucher Clinic since August 2011.

 The SOS technology as developed by the BeamMed Company (originally, the Sunlight Ultrasound
 Technologies, Israel) is based on the physical property that ultrasound waves travel faster
 through bone than soft tissue. The bone sonometer measures the time that elapses between the
 axially transmitted sound generated as an inaudible high-frequency pulsed acoustic signal at
 a center frequency of 1.25 MHz and the first reception of a signal after it has traveled
 through the selected bone. This is recorded as the SOS in m/sec. The ultrasonic waves are
 transmitted and received by transducers embedded in the ultrasound probe. As the ultrasound
 wave travels, the speed, dispersion, and attenuation of the signal is influenced by the
 density, elasticity, and cohesiveness of the medium, so that the greater the density and
 elasticity of the medium, the faster the speed of propagation [Ashman et al, 1984].

 The device consists of a desktop main unit and 3 probes of different sizes. The small probe
 (1.4cm x 2.7cm x 11cm), 900-1000 KHz will be used for this study. Calibration is performed
 each day using a standardized calibrating plastic provided by the company. The SOS is
 determined as the mean of 3 scans that are found to be statistically similar (coefficient of
 variation below 1.2%), as calculated by the software provided with the device. Based on these
 3 readings, the 95th percentile of the measured SOS is determined and used for statistical
 analysis.
Inclusion Criteria:

 -  Age: >18

 -  Gaucher disease type 1

 -  Able to undergo a DEXA test

 Exclusion Criteria:

 -  Minors