Efficacy of Panobinostat in Patients With Relapsed and Bortezomib-refractory Multiple Myeloma
Efficacy of Panobinostat in Patients With Relapsed and Bortezomib-refractory Multiple Myeloma
This study is designed to assess the effectiveness of the combination of Panobinostat plus
 Bortezomib and Dexamethasone in patients with relapsed and bortezomib refractory Multiple
 Myeloma.
This is a phase II, two stage, single arm, open label, multi-center study of oral PAN in
 combination with BTZ/Dex in patients with relapsed and refractory multiple myeloma, who are
 bortezomib-refractory and have received at least 2 prior lines of therapy. Patients must have
 been exposed to an iMID (lenalidomide or thalidomide) and progressed on or within 60 days of
 their last BTZ-containing line of therapy.
Inclusion Criteria:

 1. Patient has a previous diagnosis of multiple myeloma, based on IMWG 2003 definitions.
 All three of the following criteria must have been met:

 -  Monoclonal immunoglobulin (M component) on electrophoresis, and on immunofixation
 on serum or on total 24 hour urine

 -  Bone marrow (clonal) plasma cells ≥ 10% or biopsy proven plasmacytoma

 -  Related organ or tissue impairment (CRAB symptoms: anemia, hypercalcemia, lytic
 bone lesions, renal insufficiency, hyperviscosity, amyloidosis or recurrent
 infections)

 2. Patient must have relapsed and refractory MM and must require treatment for the
 relapsed disease

 3. Patients must have received at least 2 prior lines of therapy which include an IMiD
 (thalidomide or lenalidomide)

 4. Patient must be refractory to the last bortezomib containing line of therapy given in
 the relapsed and refractory setting defined as:

 -  having progressed on or within 60 days of the last bortezomib-containing line of
 therapy

 5. Patient has measurable disease on M protein at study screening defined by at least one
 of the following measurements as per thresholds clarified in IMWG 2003 disease
 definitions (Kyle, et al 2003):

 -  Serum M-protein ≥ 1 g/dL (≥ 10 g/L)

 -  Urine M-protein ≥ 200 mg/24 h

 6. Patients treated with local radiotherapy with or without concomitant exposure to
 steroids for pain control or management of cord/nerve root compression, are eligible.
 Two weeks must have lapsed since last date of radiotherapy, which is recommended to be
 a limited field. Patients who require concurrent radiotherapy should have entry to the
 protocol deferred until the radiotherapy is completed and 2 weeks have passed since
 the last date of therapy

 7. Patient's age is ≥ 18 years at time of signing the informed consent

 8. Patient has an Eastern Cooperative Oncology Group (ECOG) performance status (PS) of ≤
 2

 9. Patient has the following laboratory values within 3 weeks before starting study drug
 (lab tests may be repeated, as clinically indicated, to obtain acceptable values
 before screen fail is concluded but supportive therapies are not to be administered
 within the week prior to screening tests for absolute neutrophil count or platelet
 counts)

 -  Absolute neutrophil count (ANC) ≥ 1.0 x 109 /L

 -  Platelet count ≥ 70 x 109 /L

 -  Serum potassium, magnesium, phosphorus, within normal limits (WNL) for
 institution

 -  Total calcium (corrected for serum albumin) or ionized calcium ≥ LLN, and not
 higher than CTCAE grade 1 in case of elevated value

 Note: Potassium, calcium, magnesium, and/or phosphorus supplements may be given to
 correct values that are < LLN:

 -  AST/SGOT and ALT/SGPT ≤ 2.5 x ULN

 -  Serum total bilirubin ≤ 1.5 ULN (or ≤ 3.0 x ULN if patient has Gilbert syndrome)

 -  Serum creatinine levels ≤ 2.5 x ULN, or calculated creatinine clearance ≥ 40
 ml/min

 10. Patient has provided written informed consent prior to any screening procedures

 11. Patient is able to swallow capsules

 12. Patient must be able to adhere to the study visit schedule and other protocol
 requirements

 13. Women of childbearing potential (WOCBP) must have a negative serum pregnancy test at
 within 7 days prior to start of study treatment

 Exclusion Criteria:

 1. Primary refractory disease (patients that never reached at least an MR for over 60
 days under any prior therapy)

 2. Patients who have a history of prior MM treatment with a DAC inhibitor including
 panobinostat

 3. Patients who have had prior allogeneic stem cell transplantation and show evidence of
 active graft-versus-host disease that requires immunosuppressive therapy

 4. Peripheral neuropathy ≥ CTCAE grade 2

 5. Patients who will need valproic acid for any medical condition during the study or
 within 5 days prior to the first administration of study drug / treatment or who
 cannot be switch to safely to alternative anti-epileptic medication

 6. Patients who have impaired cardiac function including any of the following:

 -  Congenital long QT syndrome, complete left bundle branch block or use of a
 permanent cardiac pacemaker, history or presence of ventricular tachyarrhythmias,
 clinically significant resting bradycardia (< 50 beats per minute). Right bundle
 branch block + left anterior hemiblock (bifascicular block)

 -  QTcF > 450 msec on screening ECG

 -  Presence of unstable atrial fibrillation. Patients with stable atrial
 fibrillation are allowed in the study provided they do not meet other cardiac or
 prohibited drug exclusion criteria

 -  Previous history of angina pectoris or acute MI within 6 months

 -  Congestive heart failure (New York Heart Association functional classification
 III-IV)

 -  Patient has any other clinically significant cardiovascular disease (e.g.
 uncontrolled hypertension)

 7. Patient has an impairment of gastrointestinal (GI) function or GI disease that may
 significantly alter the absorption of panobinostat (e.g., ulcerative disease,
 uncontrolled nausea, vomiting, malabsorption syndrome, obstruction, or significant
 small bowel resection)

 8. Patient has unresolved diarrhea ≥ CTCAE grade 2

 9. Patients who have any other concurrent severe and/or uncontrolled medical condition(s)
 including, but not limited to: uncontrolled diabetes mellitus, active or uncontrolled
 infection, chronic obstructive or chronic restrictive pulmonary disease (e.g. dyspnea
 at rest from any cause), symptomatic thyroid dysfunction, significant bleeding
 tendency, that could cause unacceptable safety risks or compromise compliance with the
 protocol

 10. Patients who are using medications that have a known relative risk of prolonging the
 QT interval or of inducing Torsade de Pointes, where such treatment cannot be
 discontinued or switched to a different medication prior to starting study drug

 11. Women who are pregnant or breast feeding

 12. Patients with evidence of another malignancy not in remission or history of such a
 malignancy within the last 5 years (except for treated basal or squamous cell
 carcinoma, or in situ cancer of the cervix)

 13. Patients who have received prior to starting study treatment either radiation therapy
 to > 30% of marrow-bearing bone within 4 weeks; myelotoxic chemotherapy within 4
 weeks; or immunotherapy within 8 weeks; or who have not yet recovered from side
 effects of such therapies

 14. Patients with any significant history of non-compliance to medical regimens or
 unwilling or unable to comply with the instructions given to him/her by the study
 staff

 15. Use of chemo-, biologic or immunologic therapy and/or other investigational agents
 while the patient is on study treatment.

 16. Patient taking any anti-cancer therapy concomitantly (bisphosphonates are permitted
 only if commenced prior to the start of screening period)