Vaccine for Recurrent Urinary Tract Infections in Women
Vaccine for Recurrent Urinary Tract Infections in Women
The purpose of this study is determine whether a vaginal mucosal vaccine given to women with
 a history of recurrent urinary tract infections can reduce the number of infections occurring
 in a six-month study period, as compared to placebo treatment.
Recurrent urinary tract infections (UTIs) affect approximately 10% of women in the United
 States. Since antibiotic prophylaxis is not always effective, alternate treatments need to be
 developed. One such treatment would be immunization with a vaccine containing bacteria known
 to cause these infections. The objective of the study is to immunize susceptible women with
 inactivated bacteria contained in a vaginal suppository and to monitor the rates of
 reinfection compared to a group of women treated with placebo suppositories. Each group of
 patients will receive a total of six suppositories in the first four-months of the six-month
 study during which all UTIs and side effects will be recorded. The infection rates between
 vaccine- and placebo-treated women will be statistically analyzed to determine vaccine
 efficacy.
Inclusion Criteria:

 -  Three or more urinary tract infections in the previous year

 Exclusion Criteria:

 -  Neurogenic bladder

 -  Interstitial cystitis

 -  Urinary diversion

 -  Kidney stones

 -  Indwelling catheter