Mesotherapy Versus Systemic Therapyin Treatment of Migraine Headache
Mesotherapy Versus Systemic Therapyin Treatment of Migraine Headache
Introduction:Migraine is a prevalent disabling primary headache disorder which is classified
 in two major types; migraine without aura and migraine with aura. The aim of this study was
 to compare the efficiency of mesotherapy with systemic therapy in pain controlin patients
 with headache related tomigraine without aura.

 Methods: We conducted this prospective parallel randomized controlled trial with the patients
 admitted to the emergency department with headache related to migraine without aura. One
 group was treated with mesotherapy, and the control group with intravenous dexketoprofen.
 Changes in pain intensity at 30th minute, 60th minute, 120th minute and 24th hours after
 treatment using Visual Analogue Scale (VAS), need to use analgesic drug within 24
 hours,re-admission with same complaint to emergency department (ED) within 72 hours, and
 adverse effect rate of the methods were compared between groups.
Inclusion Criteria:

 -  18 years and older age, and (2)

 -  Admission to Emergency Department (ED) with headache related to the migraine without
 aura.

 Exclusion Criteria:

 -  Taking analgesic drugs before admission,

 -  Having VAS score of lower than 4 on admission,

 -  Having diabetes mellitus,

 -  Body mass index>30 kg/m2,

 -  Pregnancy,

 -  Lactation,

 -  Having active bleeding or bleeding disorder,

 -  Having active or recurrent gastrointestinal hemorrhage or ulcer, or history of these
 conditions,

 -  Having a serious or life-threatening condition (stroke, intracranial hemorrhage, heart
 attack, cardiac tamponade, pneumothorax, hemothorax, flail chest, etc.).