Automated Adjustment of Oxygen on Patient With Acute COPD Exacerbation - FreeO2 HypHop
Automated Adjustment of Oxygen on Patient With Acute COPD Exacerbation - FreeO2 HypHop
The aim of this study is to evaluate if automated adjustment of oxygen (with FreeO2 device)
 can reduce the hospital length of stay for acute exacerbation of COPD with comparison of
 manual oxygen titration.
The aim of this study is to evaluate if automated adjustment of oxygen (with FreeO2 device)
 can reduce the hospital length of stay for acute exacerbation of COPD with comparison of
 manual oxygen titration.

 Patients with severe acute exacerbation of COPD requiring hospitalization will be included in
 this randomized controlled study and will be managed with either manual oxygen titration or
 automated oxygen titration (FreeO2 arm).

 The impact on the hospital length of stay will be evaluated.
Inclusion Criteria:

 -  COPD or suspected COPD ( Age>40, active or smoking history > 10pack/years), -

 -  Acute exacerbation (increasing dyspnea recently)

 -  One or more of the following criteria: increased sputum, modification of sputum
 purulence,increased dyspnea,

 -  Moderate oxygen therapy: Oxygen flow < 8 lpm (or FiO2 < 0.60) to maintain a SpO2 >or =
 92% (for long term oxygen therapy, the oxygen flow must be greater than baseline flow
 to maintain SpO2 > or = 92%)

 Exclusion Criteria:

 -  Patient refusal

 -  COPD exacerbation with diagnosis highly related to pulmonary embolism, cardiac
 pulmonary edema, pneumothorax or sedative overdose

 -  No SpO2 signal

 -  Encephalopathy score > 2

 -  Delirium

 -  Other respiratory support needed (intubation or NIV)

 -  Patient on withdrawal life support

 -  Advance neoplasia (palliative stage) or terminal respiratory distress

 -  Unavailability of FreeO2 device at the randomisation

 -  Non optimal patient collaboration