Study of Myocardial Deformation Parameters in Patients With Hypertrophic Cardiomyopathy
Study of Myocardial Deformation Parameters in Patients With Hypertrophic Cardiomyopathy
The purpose of the study is to investigate the potential correlations of global longitudinal
 strain and peak left atrial strain, measured by speckle tracking echocardiography with the
 severity of hypertrophic cardiomyopathy and the risk for arrhythmias.

 Specifically the investigational questions are:

 1. Is there a correlation between myocardial deformation parameters of the left heart
 chambers with other important ultrasound parameters (eg maximal wall thickness, presence
 of subaortic obstruction, etc.) in patients with hypertrophic cardiomyopathy?

 2. Is there a correlation between myocardial deformation parameters of the left heart
 chambers and the symptomatology or functional capacity of patients with hypertrophic
 cardiomyopathy?

 3. Is there a correlation between the myocardial deformation parameters of the left heart
 chambers and the exercise capacity, as evidenced by the cardiopulmonary exercise test,
 in patients with hypertrophic cardiomyopathy?

 4. Is there a correlation between myocardial deformation parameters of the left heart
 chambers with the risk of ventricular or supraventricular arrhythmias in patients with
 hypertrophic cardiomyopathy?

 5. Is there a correlation between myocardial deformation parameters of the left heart
 chambers and risk factors for sudden death?
Myocardial deformation parameters of the left heart chambers are of particular clinical
 importance because of their possible association with the severity of HCM and the presence of
 arrhythmias. However,current literature appears conflicting.

 This is a prospective cohort study aiming to examine the echocardiographic parameters of
 myocardial deformation, estimated by the "speckle tracking" method, and their correlation
 with clinical presentation and symptomatology, other imaging parameters, exercise capacity,
 arrhythmias (ventricular or supraventricular) and risk factors for sudden death in patients
 with hypertrophic cardiomyopathy.

 Although, similar efforts have been made in international literature, they are scarce and
 their results contradictory. The present study is the first to be performed in a Greek
 population, a fact that is particularly important given the genetic heterogeneity of the
 disease.
Inclusion Criteria:

 -Patients with diagnosed hypertrophic cardiomyopathy

 Exclusion Criteria:

 -  Concomitant severe valvular heart disease

 -  Prior myocardial infarction

 -  History of atrial fibrillation