Time-restricted Feeding for Treating Polycystic Ovary Syndrome (PCOS)
Time-restricted Feeding for Treating Polycystic Ovary Syndrome (PCOS)
Intermittent fasting is an increasingly popular diet pattern of alternating eating and
 dieting.One particular form of intermittent fasting is the so-called time-restricted feeding
 (TRF). TRF allows for ad libitum feeding within a large window of time each day, and does not
 require any calorie counting. There is growing evidence that it can lose weight, reduce
 insulin resistance and improve cardiometabolic health. Polycystic ovary syndrome (PCOS) is
 the most common reproductive endocrine and metabolic disease affecting women of childbearing
 age. PCOS shows anovulation or oligoovulation, hyperandrogenemia and ovarian polycystic
 changes. Insulin resistance and obesity are common features of PCOS. Whether the TRF impacts
 women with PCOS is still unknown due to the paucity of data in this area. To explore the
 effects of TRF on the endocrine and metabolic profile in overweight women with PCOS, a 6-week
 single-arm trial, divided into 2 consecutive periods: (1) 1-week baseline period; and (2)
 5-week TRF period, will be implemented.
Inclusion Criteria:

 Age ≥ 18 years; BMI≥24kg/m2; Anovulation; Rott-PCOS.

 Exclusion Criteria:

 Taking weight loss or regulate hormone secretion medications in recent 6 months; The body
 weight fluctuated more than 5% in the past 3 months; Preparation for pregnancy, having been
 in pregnancy or lactation; Perimenopausal; Night-shift workers; Fasting more than 16 hours
 a day; Hypotension; Patients with other diseases (such as congenital adrenal hyperplasia,
 Cushing syndrome, androgen-secreting tumors, hyperprolactinemia, diabetes, thyroid
 diseases, severe serious cardiovascular, gastrointestinal, kidney or liver diseases);
 Alcohol intake more than 100g per week; Smoking within 3 months; Engaging in high-intensity
 exercise.