Nurse Smoking Cessation of Patients With Chronic Obstructive Pulmonary Disease (COPD) With Nicotine Replacement Therapy (NRT) and Behavioral Support
Nurse Smoking Cessation of Patients With Chronic Obstructive Pulmonary Disease (COPD) With Nicotine Replacement Therapy (NRT) and Behavioral Support
This is a smoking cessation study with COPD patients where the researchers wanted to evaluate
 if nicotine sublingual tablets or placebo combined with low or high individual support could
 increase ½ and 1 year quit rates.
Placebo, controlled, randomized, double-blind trial with 400-1000 smoking COPD patients with
 FEV-1 < 90 % predicted normal with the use of nicotine sublingual nicotine tablets or placebo
 for 12 weeks combined with individual clinic visits with low or high intensity conducted by
 trained nurses in several centres in pulmonary clinics in Denmark. Outcome was smoking
 cessation and smoking reduction after ½ and 1 year as self declared smoking status confirmed
 by carbon monoxide in expired air< 10 ppm. Secondary outcomes were change in body-weight,
 quality of life (SF-36 and SGRQ), symptoms, lung function, adverse events.
Inclusion Criteria:

 -  COPD patients (FEV1/FVC<70% and FEV1<90 % predicted)

 -  Smoking 1 cigarette daily or more

 -  Willing to follow the protocol

 Exclusion Criteria:

 -  Used NRT or bupropion the last week

 -  Not able or willing to adhere to the protocol

 -  Estimated survival < 1 year