ObinutuzuMab AtezOlizumab and VenetocLax in RichTer transfOrmation
ObinutuzuMab AtezOlizumab and VenetocLax in RichTer transfOrmation
This study is a multicenter, open-label, uncontrolled, phase II trial aimed to establish the
 safety and tolerability of venetoclax, atezolizumab and obinutuzumab combination in Richter
 Transformation of CLL.
This study is a multicenter, open-label, uncontrolled, phase II trial. Initial safety run
 phase is designed to establish the safety and tolerability of venetoclax, atezolizumab and
 obinutuzumab combination.

 There is no dose-finding step. The doses of obinutuzumab and atezolizumab in lymphomas were
 previously clearly established in combination (Till BG et al. Blood 2015).

 It has also been shown that in a balance between efficacy and toxicity, the recommended dose
 of venetoclax single-agent in Follicular Lymphoma (FL) and DLBCL was 800 mg daily (Davids MS
 et al. JCO 2017 ). The investigators chose the lower dose level (400 mg) for this study, also
 corresponding to the registered one for patients with CLL, in association with two other
 drugs. Nine patients having achieved 9 weeks (=3 cycles) of treatment (6 doses of
 obinutuzumab, 3 doses of atezolizumab, 7 weeks of venetoclax) or having discontinued
 treatment within the first 9 weeks of treatment will be enrolled in this cohort for safety
 profile. If one of these 9 patients prematurely discontinue at least one of study drugs for a
 reason other than safety (e.g. for disease progression), he/she will be replaced.

 All AEs occurring during the course of the study will be captured, regardless of their
 intensity / grading. Grading of AEs will be completed according to the National Cancer
 Institute (NCI) Common Terminology Criteria for Adverse Events (CTC-AE), version 4.0. Based
 on known safety profile of the 3 drugs, some adverse events of special interest will be
 assessed. During the initial safety run phase, all haematological toxicities and
 immune-related toxicities whatever the grade, and grade ≥ 2 for other toxicities will be
 monitored and, in this case, safety review meeting will be organized with Independent Data
 Monitoring Committee (IDMC) members. In case of more than 3 non-infective and non-hematologic
 grade ≥4 adverse events in the initial safety run cohort that according to the experience of
 the investigators are considered related to the combination treatment, inclusions will be
 stopped and IDMC members will evaluate the possibility of an early enrollment termination.

 The treatment schedule applied to the initial safety run cohort will be employed for the
 remaining patients.

 The 9 patients from the safety run will be included in the efficacy analysis. A response
 evaluation according with Lugano criteria for aggressive lymphomas (Cheson et al. JCO 2014)
 will be performed at the end of the sixth cycle to define treatment efficacy and, in case of
 achievement of 16 responses, treatment will be considered successful.

 The planned enrollment for this study is 28 patients.

 Patients will receive 35 cycles of treatment:

 -  From cycle 1 to cycle 8 patients will receive a combination of obinutuzumab,
 atezolizumab and venetoclax

 -  From cycle 9 to cycle 18 patients will receive atezolizumab and venetoclax

 -  From cycle 19 to cycle 35 patients will receive venetoclax monotherapy.
Inclusion Criteria:

 1. Ability to understand and the willingness to sign a written informed consent document

 2. Signed Informed Consent

 3. Confirmed diagnosis of chronic lymphocytic leukemia or small lymphocytic lymphoma as
 IW-CLL 2008 criteria (Hallek et al, 2008) with biopsy proven transformation to diffuse
 large B cell lymphoma (DLBCL), consistent with Richter's Syndrome

 4. Age greater than or equal to 18 years

 5. ECOG performance status <= 2

 6. Patients must meet the following hematologic criteria at screening, unless they have
 significant bone marrow involvement of their malignancy confirmed on biopsy:

 -  Absolute neutrophil count >=1000 cells/mm3 (1.0 x 10^9/L).

 -  Platelet count >= 50,000 cells/mm3 (50 x 10^9/L) within 7 days of screening

 -  Total hemoglobin > 9 g/dL (without transfusion support, unless anemia is due to
 marrow involvement of CLL)

 7. Subject must have adequate coagulation, renal, and hepatic function, per laboratory
 reference range at screening as follows:

 -  Activated partial thromboplastin time (aPTT) and International normalized ratio
 (INR) > 1.5 x ULN for patients not receiving therapeutic anticoagulation;

 -  Creatinine <= 1.5 x ULN or creatinine clearance >= 50 mL/min based on
 Cockcroft-Gault formula;

 -  Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) <= 2.5 × ULN;

 -  Bilirubin <= 1.5 × ULN;

 8. Subjects with Gilbert's Syndrome or resolving autoimmunohemolytic anemia may have a
 bilirubin up to 3.0 × ULN and are still eligible

 9. Negative pregnancy tests as verified by the investigator prior to starting any
 treatment.

 Exclusion Criteria:

 1. Prior treatment for Richter transformation.

 2. Prior treatment with obinutuzumab anti PD-1 or PDL-1 antibodies.

 3. Prior treatment with venetoclax.

 4. Hypersensitivity to obinutuzumab, venetoclax or atezolizumab or their formulation
 excipients.

 5. Patients with the Hodgkin variant transformation of CLL.

 6. Prolymphocytic transformation.

 7. Patients with a previous history of indolent B cell malignancies other than CLL.

 8. History of other malignancy other than CLL and Richter syndrome that could affect
 compliance with the protocol or interpretation of results with the exception of:

 1. Patients with curatively treated basal or squamous cell carcinoma or stage 1
 melanoma of the skin or in situ carcinoma of the cervix

 2. Patients with a malignancy that has been treated with surgery alone with curative
 intent. Individuals in documented remission without treatment for > 2 years prior
 to enrollment may be included at the discretion of the Sponsor-Investigator.

 3. Low-risk prostate cancer on active surveillance.

 9. Evidence of significant, uncontrolled concomitant diseases that could affect
 compliance with the protocol or interpretation of results or that could increase risk
 to the patient, including renal disease that would preclude chemotherapy
 administration or pulmonary disease (including obstructive pulmonary disease and
 history of bronchospasm).

 10. Known active bacterial, viral, fungal, mycobacterial, parasitic, or other infection
 (excluding fungal infections of nail beds) at study enrollment, or any major episode
 of infection requiring treatment with IV antibiotics or hospitalization (relating to
 the completion of the course of antibiotics) within 4 weeks prior to Cycle1, Day1.

 11. Clinically significant history of liver disease, including autoimmune hepatitis,
 current alcohol abuse, or cirrhosis.

 12. Presence of positive PCR for hepatitis B, hepatitis C or positive hepatitis B surface
 antigen.

 13. Patients with uncontrolled autoimmune hemolytic anemia or immune thrombocytopenia.

 14. History of active autoimmune disease.

 15. History of idiopathic pulmonary fibrosis, organizing pneumonia (e.g., bronchiolitis
 obliterans), drug-induced pneumonitis, idiopathic pneumonitis, or evidence of active
 pneumonitis per chest CT scan at screening. History of radiation pneumonitis in the
 radiation field (fibrosis) is allowed.

 16. Concurrent systemic immunosuppressant therapy within 28 days of the first dose of
 study drug.

 17. Corticosteroids are allowed, but must be dosed at prednisone 30 mg (or equivalent) or
 lower prior to the start of chemotherapy.

 18. Vaccinated with live, attenuated vaccines within 4 weeks of first dose of study drug.

 19. Known bleeding disorders (eg, von Willebrand's disease) or hemophilia.

 20. Requires anticoagulation with vitamin K antagonists (e.g. phenprocoumon, warfarin)

 21. History of human immunodeficiency virus (HIV) or active hepatitis C virus (HCV) or
 active hepatitis B virus (HBV).

 22. Major surgery within 4 weeks of first dose of study drug.

 23. Any life-threatening illness, medical condition, or organ system dysfunction that, in
 the investigator's opinion, could compromise the subject's safety or put the study
 outcomes at undue risk.

 24. Patients with infections requiring IV treatment (Grade 3 or 4) within the last 2
 months prior to enrolment.