A Histomorphometric Analysis Following Sinus Augmentation Using Two Different Bone Graft Materials.
A Histomorphometric Analysis Following Sinus Augmentation Using Two Different Bone Graft Materials.
The purpose of this investigator-initiated study is to compare new bone formation through
 histomorphometric analysis following maxillary sinus augmentation using two different bone
 graft materials. A total of twenty, sinus augmentation via a lateral approach will be
 performed for subjects requiring sinus augmentation for implant placement and randomly
 divided into 2 groups. These subjects will receive one of two different bone graft materials:
 1) Anorganic bovine bone matrix- InterOss (Group A), 2) Anorganic bovine bone matrix- Bio-oss
 (Group B). At the time of implant placement (eight months after the sinus augmentation
 procedure), two bone biopsies will be collected from augmented site for the histomorphometric
 analysis. The percentage of vital bone will be measured and analyzed statistically, also the
 following will be measured: percentage of non-vital bone, percentage of non-bone material
 (xenograft), and the percentage of connective tissue.
Inclusion Criteria:

 1. Over 18 years old who are able to read and sign an informed consent form.

 2. Patient who has good oral hygiene (Full-mouth plaque score <25%).

 3. Subject would be available for study monitoring and follow-up visits.

 4. Patients with missing teeth in the maxillary posterior region who will require sinus
 augmentation for implant placement. The patients may be partially or completely
 edentulous.

 5. Patient is a candidate for delayed implant placement approximately 8 months following
 sinus grafting

 Exclusion Criteria:

 1. Alcohol, drug dependency.

 2. Signs or symptoms of chronic maxillary sinus disease.

 3. Current smoker.

 4. History of head and neck radiation treatment.

 5. Poor health, conditions like uncontrolled diabetes, uncontrolled hypertension or other
 uncontrolled systemic disease.

 6. Physical or psychological reason that might affect the surgical procedure or the
 subsequent prosthodontic treatment and/or required follow-up examinations.

 7. Also, subjects who are nursing or pregnant will be excluded from the study.