Surgical Treatment of Intra-spinal Canal Tumors Via Trans-Quadrant Channel
Surgical Treatment of Intra-spinal Canal Tumors Via Trans-Quadrant Channel
Intra-spinal canal tumors are the general term of primary tumors from spinal cord or various
 tissues in the spinal canal and adjacent to the spinal cord, while the metastatic tumors are
 those from other sites other than spinal canal. Intra-spinal canal tumor is one of the most
 common diseases in neurosurgery, and surgery is the most effective treatment. Conventional
 open surgery is required to remove the posterior structures of the spine, which would lead to
 fracture of the posterior tension band, soft tissue injury, spine instability, and even spine
 deformity. So it is very important to protect and rebuild the posterior tension band for the
 stability of the spine. The team of Dr. John P. Kostuik from the Department of Orthopedics
 and Neurosurgery, the Johns Hopkins University, firstly introduced minimally invasive surgery
 for cervical and lumbar degenerative disease. However it has not been applied to the
 treatment of intra-spinal canal tumors. To date, the microsurgery of intra-spinal tumor
 through the trans-Quadrant channel pathway has not been widely performed in clinical
 practice. The investigators performed the microsurgery of intra-spinal canal tumor through
 the trans-Quadrant pathway in some patients previously and succeeded in the surgical
 treatments. The investigators analyzed the clinical data retrospectively, including surgical
 incision length, the volume of bleeding during operation, post-operative drainage volume,
 post-operative out-of-bed time point, post-operative length of stay in hospital, and
 post-operative visual analog pain (VAP) score. The group of patients using microsurgical
 technique through trans-Quadrant channel pathway showed better outcome compared with the
 group of patients using conventional open surgery. This innovation of microsurgery showed
 fewer traumas and bleeding, more rapid recovery, better prognosis and more safety in
 practice. Since there are some limitations to the retrospective study, it is necessary to
 design a prospective randomized controlled trial of the treatment of intra-spinal canal
 tumors using microsurgical technique through trans-Quadrant channel pathway.
This study is the prospective randomized controlled clinical trial.

 1. Patient Recruitment: Patients who meets the diagnostic criteria of intra-spinal canal
 tumor and has surgical indications from May 2016 to June 2018 in the department of
 neurosurgery of our hospital could be recruited.

 2. Screening: Demographic characteristics, such as gender, age, history of diseases
 (including but not limited in diabetes, heart disease, smoking history, and operation
 history, etc.), related laboratory tests (blood routing test, liver and kidney
 functions, electrolytes, blood coagulation function, and ECG, etc.) before entering
 either group.

 3. Grouping: Patients who meets the diagnostic criteria and does not meet the exclusion
 criteria would be assigned into the experimental group and control group randomly. The
 informed consent forms should be signed before grouping.

 4. Surgery: Patients in the experimental group will receive operation using microsurgical
 techniques through trans-Quadrant channel pathway. Patients in the control group will
 receive conventional open surgery.

 5. Post-operative Observation and Follow-up: Clinical data will be collected after surgery
 and during follow-up. The time points include the 1st day, 7th day, 30th day, 90th day,
 and 180th day after surgery.

 6. Statistical Analysis: Statisticians are blinded to the clinical data and grouping. The
 software SPSS (V. 16.0) will be used in statistics.
Inclusion Criteria:

 -  The patient should meet the diagnostic criteria of intra-spinal canal tumors and the
 indications for surgery. Meanwhile, the length of tumor should no more than 5 cm, and
 the cross-sectional area should be less than 2/3 of the respective area of the spinal
 canal.

 -  The patient was never be treated with any spinal surgery.

 -  There was no cognitive impairment before onset of diseases or other diseases which can
 cause cognitive dysfunction.

 -  The patient should sign the informed consent forms.

 Exclusion Criteria:

 -  The patient is diagnozed as non intra-spinal canal tumors, spinal degenerative
 diseases, or other spinal diseases.

 -  The patient received spinal surgery previously.

 -  The patient suffered from serious heart, lung, liver, or kidney insufficiency.

 -  The patient has other spinal and spinal cord diseases rather than intra-spinal canal
 tumor, such as disc herniation, vertebral fractures.

 -  The patient has severe diabetes, coronary heart disease, coagulation disorders,
 difficult to correct before operation, or cannot tolerate surgery.

 -  The patient has other surgical contraindications.

 -  The patient is pregnant or breast-feeding.

 -  The patient is unable to sign the informed consent voluntarily.