A Study to Evaluate the Effects of ABX-1431 on Patients With Functional Dyspepsia
A Study to Evaluate the Effects of ABX-1431 on Patients With Functional Dyspepsia
A Single-Dose Study to Evaluate the Effects of ABX-1431 on Gastric Accommodation and Nutrient
 Volume Tolerance in Patients with Functional Dyspepsia.
This is a single dose, randomized, placebo-controlled, two period crossover study. This study
 will assess the effects of ABX-1431 on gastric physiology in patients with functional
 dyspepsia, who have clinical evidence of impaired gastric accommodation with meals.

 All patients will undergo a screening visit for enrollment criteria. Eligible patients will
 be treated with a single dose of ABX-1431 HCl or placebo followed by IGP measurement,
 measured with a high resolution manometry probe during a nutrient volume tolerance test.
 After a washout period of at least one week, patients will undergo identical procedures with
 the other treatment.

 This study will enroll 12 functional dyspepsia (FD) patients.
Inclusion Criteria:

 -  Patient has functional dyspepsia, postprandial distress syndrome (PDS) subtype,
 defined by the Rome III criteria.

 -  Patient has evidence of impaired gastric accommodation.

 -  Patient's Rome III Questionnaire results indicates that the intensity of co-existing
 epigastric pain and/or epigastric burning may be present, but have the same or lesser
 intensity than the evaluations of postprandial fullness or early satiety (i.e.
 epigastric pain and burning are not the prominent symptoms of the patient's functional
 dyspepsia).

 -  Patient recall of symptoms of gastrointestinal reflux over the past 8 weeks has no
 more than 2 episodes per week of heartburn or regurgitation.

 -  Patient is a male or female between 18 and 65 years of age at the pre-study/screening
 visit.

 -  Patient has a Body Mass Index (BMI) >18 to ≤30 kg/m2 at the pre-study/screening visit.

 -  Patient is judged to have no unmanaged significant disease or disorder based on
 medical history, physical examination, vital sign measurements, and laboratory safety
 obtained at pre-study/screening, and within 36 hours prior to first administration of
 study drug.

 -  Patient has no clinically significant abnormality of ECG performed at pre
 study/screening, and prior to first administration of study drug.

 -  Patient is willing to undergo the nutrient volume tolerance tests.

 Exclusion Criteria:

 -  Patient is under the age of legal consent.

 -  Female patients who are pregnant or breastfeeding.

 -  Patient has a personal history of a clinically significant psychiatric disorder
 (including severe affective disorder, anxiety disorder, post-traumatic stress
 disorder, psychotic disorder or drug-induced psychoses).

 -  Patient has a first-degree family history of schizophrenia, severe affective disorder,
 severe anxiety disorder, or other psychosis.

 -  Patient is taking antidepressants including SSRIs, SNRIs, tricyclic antidepressants,
 or atypical antidepressant medications such as bupropion, mirtazapine, trazodone or
 agomelatine. Patients taking these or other types of medicine for anxiety are also
 excluded. Patients who have discontinued antidepressants more than 6 months ago may be
 enrolled at the discretion of the Investigator. Patients who are taking gabapentin or
 pregabalin or buspirone are also excluded.

 -  Patient is mentally or legally incapacitated, has significant emotional problems at
 the time of pre-study/screening visit or is expected to have potential for mental
 incapacitation during the conduct of the study.

 -  Patient has had any gastrointestinal surgery. Those having undergone a simple
 appendectomy more than 1 year prior to the pre-study/screening visit may participate.

 -  Patient has had any acute gastrointestinal illness in the past 3 months.

 -  Patient has laboratory tests at screening or within 36 hours of first administration
 of study drug outside of these limits: Aspartate transaminase (AST) >1.5 x upper limit
 of normal (ULN) or Alanine transaminase (ALT) >1.5 x ULN.

 -  Patient has an estimated creatinine clearance (CrCl) of ≤80 mL/min based on the
 Cockcroft-Gault equation. An actual creatinine clearance, as measured using a 24-hour
 urine collection, may be used in place of, or in conjunction with the Cockcraft-Gault
 calculation. Patients with an actual or calculated creatinine clearance that is in the
 range of 72-79 mL/min (i.e., within 10% of 80 mL/min) may be enrolled in the study at
 the discretion of the Investigator.

 -  Patient has an active or prior history of neurological disorder, including but not
 limited to seizure disorder, epilepsy, stroke, neurological disease, cognitive
 impairment, head trauma with prolonged loss of consciousness (>10 minutes), or
 migraine headaches.

 -  Patient has a history of clinically significant neoplastic disease, with the exception
 of adequately treated localized or in situ non-melanoma carcinoma of the skin (e.g.,
 basal cell carcinoma) or the cervix.

 -  Patient has a family history of long QT syndrome.

 -  Patient has a QTc interval of >450 msec (male patients) or >470 msec (female
 patients).