Dexamethasone for Postoperative Nausea and Vomiting
Dexamethasone for Postoperative Nausea and Vomiting
The investigators want to test the efficacy of these anesthetic antiemetic measures
 collectively with or without ondansetron or dexamethasone, in the prevention of postoperative
 nausea and vomiting (PONV) in patients undergoing laparoscopic cholecystectomy.
More than half of the patients undergoing laparoscopic cholecystectomy will have
 postoperative nausea and vomiting (PONV). PONV is related to surgical, anesthetic and patient
 factors.

 We want to test the efficacy of these anesthetic antiemetic measures collectively with or
 without ondansetron or dexamethasone, in the prevention of PONV in patients undergoing
 laparoscopic cholecystectomy.

 Three groups to be studied : (Group O) will receive 4 mg ondansetron, (Group D) will receive
 8 mg dexamethasone and (Group P) will receive normal saline .
Inclusion Criteria:

 -  (ASA) grade I and II, aged (18-70 years) who are scheduled for elective laparoscopic
 cholecystectomy under general anesthesia at the department of Anesthesia and Intensive
 Care, University of Jordan, Amman, Jordan between November 2007 and March 2008

 Exclusion Criteria:

 -  All patients who received antiemetics or cortisone within 48 hr before surgery or
 those who required opioids before and after surgeries

 -  Pregnant, breast feeding ladies

 -  Any patient with BMI (Body Mass Index) > 34 kg/m²

 -  Patient with gastrointestinal, hepatic, renal, mental or psychiatric illnesses or
 those with history of motion sickness were also excluded from the study protocol