Menstrual Cycle on Injection Pain of Rocuronium
Menstrual Cycle on Injection Pain of Rocuronium
This study evaluates the effects of rocuronium injection pain to menstrual cycle phases.Half
 of participants will receive follicular phase, while the other half will receive luteal
 phase.
Menstrual period includes a spectrum of emotional and somatic symptoms observed in luteal
 phase of menstrual cycle, which are disappeared after menstruation.

 During menstrual cycle, fluctuation in sexual hormones results in attitude change and
 alteration in pain perception.

 Different studies reported some interactions between sex hormones and central nervous system,
 which might be linked to activity of serotonin and beta-endorphin in the brain.

 Pain perception differs during menstrual cycle.

 It has been recommended that estrogens might have an influence on somatic sensory process.

 Some studies reported a significant effect of pain sensitivity with higher levels of
 progesterone and some other studies reported similar patterns for pain perception.

 There are reports of more complaint of pain in luteal phase of menstruation, which is
 suggested as the reason for functional changes in women during menstrual cycle.
Inclusion Criteria:

 -  American Society of Anesthesiology Classification (ASA) I-II

 -  18-45 years

 -  Regular menstrual cycle

 Exclusion Criteria:

 -  Irregular menstrual cycles

 -  Patients receiving hormones or drugs affecting the ovulatory cycle

 -  Amenorrhea

 -  Pregnancy

 -  Climacteric patients