A Retrospective Study of the Relationship Between White Matter Hyperintensities(WMHs) Within the Cholinergic Pathways and the Cognition of PD Patients After Bilateral STN DBS
A Retrospective Study of the Relationship Between White Matter Hyperintensities(WMHs) Within the Cholinergic Pathways and the Cognition of PD Patients After Bilateral STN DBS
To retrospectively investigate the relationship between the Cholinergic Pathways
 Hyperintensities Scale (CHIPS) score and the change of cognitive status of Parkinson's
 disease (PD) patients after bilateral subthalamic nucleus deep brain stimulation (STN DBS).
In this observational study, we will retrospectively analyze 38 PD patients who received
 bilateral STN DBS in the First Affiliated Hospital of Sun Yat-sen University during the year
 of 2008-2012. All patients will be evaluated by Unified Parkinson's Disease Rating Scale part
 III(UPDRSIII) before and after operation. Mini-Mental State Examination (MMSE), Montreal
 Cognitive Assessment(MoCA) in the on medication condition pre-operation and on stimulation on
 medication condition post-operation. The follow-up time points are one week pre-operation and
 6, 12, 24 months post-operation. Before operation, white matter hyperintensities（WMHs）in the
 cholinergic pathways will be determined on a 3.0 Tesla MRI, using the visual rating scale of
 Cholinergic Pathways Hyperintensities Scale (CHIPS). A correlation analysis will be conducted
 to investigate the relationship between CHIPS score and the change of cognitive status of PD
 patients after bilateral STN DBS retrospectively.
Inclusion Criteria:

 -  Clinical diagnosis of Parkinson's disease according to United Kingdom Parkinson's
 Disease Brain Bank Criteria

 -  Experience bilateral STN DBS surgery in the First Affiliated Hospital, Sun Yat-sen
 University, China.

 -  Preoperative 3.0 Tesla MRI scanning.

 Exclusion Criteria:

 -  Loss to follow-up

 -  Participation in other clinical trials