Natural History of Hypereosinophilia and Hypereosinophilic Syndromes
Natural History of Hypereosinophilia and Hypereosinophilic Syndromes
Unexplained chronic hypereosinophilia (HE) and hypereosinophilic syndromes (HES) are
 heterogeneous regarding the organ involvements (heart, lungs, skin, .. or none), the
 evolutionary profiles, the response to treatments.

 Underlying mechanisms are largely unknown and may associate genetic predisposing factors
 (germinal ? somatic?), environmental factors (alimentation, tobacco use, hormones,
 infections, ..) The COHESion study aims to study all clinical and biological characteristics
 of HE/HES patients and their evolutionary profiles, with a focus on genetic factors and the
 mechanisms supporting transitory or persistant chronic HE/HES (in absence of any well
 identified extrinsic trigger like drugs, parasitosis, ..)
There is currently no data on the natural history of unexplained chronic hypereosinophilia
 (HE) and hypereosinophilic syndromes (HES). Clinical practice shows that HE/SHE patients can
 present 4 evolutionary profiles:

 A. a single flare-up of their disease, with favourable evolution spontaneously or under
 corticosteroid therapy, without further recurrence B. recurrent flare-ups with a variable
 free interval of several months to several years, with or without persistent eosinophilia
 between flare-ups C. a chronic disease requiring the continuation of a substantive treatment
 D. chronic asymptomatic HE for years: the mechanisms involved in the occurrence of possible
 organ damage are unknown

 The primary objective of the study is to describe the frequency of the different clinical
 manifestations during the diagnostic and follow-up of the hypereosinophilic syndrome (HES).
 The primary endpoint is the frequency of the different clinical manifestations and/or organs
 damage related to eosinophilia.
Inclusion Criteria:

 -  Men or Women of any age :

 -  With the diagnosis criteria of hyperosinophlia OR hypereosinophilic syndrome OR
 specific organ eosinophilic disease according to the consensus conference of the
 International Cooperative Working Group on Eosinophil Disorders (ICOG-EO)

 -  With an AEC > 1500/mm3 or organ damage related to the presence of eosinophils in the
 tissues or organs whatever the context (idiopathic, clonal or reactive, including
 drug-related, parasitic or allergic)

 -  HES diagnosis since 2005/01/01

 -  Patients socially insured

 -  Patient who agreed to participate to the study, its proceedings and duration.

 Exclusion Criteria:

 -  Known HIV infection

 -  Not socially insured

 -  Person unable to receive a enlighten information

 -  Person who refuse to sign the consent

 -  Persons deprived of their liberty

 -  Persons benefiting from a system of legal protection (tutelage / guardianship)