Safety and Immunogenicity of 3 Lots of GSK Biologicals' HBV-MPL Vaccine and Engerix™-B in Healthy Volunteers ≥ 15y
Safety and Immunogenicity of 3 Lots of GSK Biologicals' HBV-MPL Vaccine and Engerix™-B in Healthy Volunteers ≥ 15y
This study was conducted to evaluate the lot-to-lot consistency of three lots of HBV-MPL
 vaccine and to compare their safety and immunogenicity with that of Engerix™-B.
At the time of conduct of this study, the sponsor GlaxoSmithKline was known by its former
 name SmithKline Beecham
Inclusion Criteria:

 -  A male or female aged ≥ 15 years at the time of the first vaccination. In Centre 103
 (Germany) and Centre 1 (Netherlands), only subjects ≥ 18 years will be enrolled.

 -  Free of obvious health problems as established by medical history and clinical
 examination before entering into the study.

 -  Written informed consent obtained from the subject and/or from the parent or guardian
 of the subject.

 -  If the subject was a female, she was of non-childbearing potential, if of childbearing
 potential, she was abstinent or used adequate contraceptive precautions for one month
 prior to enrollment and up to two months after the last vaccination

 Exclusion Criteria:

 -  Use of any investigational or non-registered drug or vaccine other than the study
 vaccine (s) during the study period or within 30 days preceding the first dose of
 study vaccine.

 -  Planned administration/ administration of a vaccine not foreseen by the study protocol
 during the period starting from 30 days before each dose of vaccine and ending 30 days
 after.

 -  Previous vaccination against hepatitis B.

 -  History of non-response to previous hepatitis B vaccination.

 -  Known exposure to hepatitis B within the past 6 weeks.

 -  History of hepatitis B infection.

 -  Confirmed human immunodeficiency virus (HIV) infection.

 -  A family history of congenital or hereditary immunodeficiency.

 -  History of allergic disease or reactions likely to be exacerbated by any component of
 the vaccine.

 -  Acute disease at the time of enrollment.

 -  Hepatomegaly, right upper quadrant abdominal pain or tenderness.

 -  Administration of immunoglobulins and/or any blood products within the three months
 preceding the first dose of study vaccine or planned administration/ administration
 during the study period.

 -  Pregnant or lactating female