Dynamic Profiles of Cytokine/Chemokine in Severe Acute Respiratory Syndrome
Dynamic Profiles of Cytokine/Chemokine in Severe Acute Respiratory Syndrome
Severe acute respiratory syndrome (SARS) is an emerging infectious disease caused by a novel
 coronavirus (SARS-CoV). The major clinical features of SARS include fever, dyspnea,
 lymphopenia, and a rapid progression of pulmonary infiltrates on chest radiologic images. The
 SARS-related deaths have resulted mainly from pulmonary complications, including progressive
 respiratory failure due to alveolar damage and acute respiratory distress syndrome (ARDS).
 Pathological changes in SARS suggest that SARS sequelae such as infiltration of PMN in lung
 tissue, multiple organ dysfunction and ARDS have been associated with cytokines and chemokine
 dysregulation. Some patients still manifested lung injury at a time when the viral load was
 falling also supports the immune nature of the lung damage. We therefore undertook an
 analysis of dynamic production of cytokine/chemokines in SARS patients with an initial normal
 chest radiograph in order to improve understanding of disease pathogenesis and improve
 patient management.
Inclusion Criteria:

 -  SARS group: Patients with SARS

 Exclusion Criteria:

 -  Hospital acquired pneumonia