Study of Antithrombotic Treatment After IntraCerebral Haemorrhage
Study of Antithrombotic Treatment After IntraCerebral Haemorrhage
The study evaluates the effects of antithrombotic drugs (anticoagulant drugs or antiplatelet
 drugs) for prevention of ischaemic events in patients With recent intracerebral haemorrhage.
Patients with spontaneous ICH have an increased risk of recurrent ICH and they also have an
 increased risk of ischaemic diseases. Around 40-50% of patients use, or have an indication,
 for antithrombotic drugs at the time of ICH. However, little is known about the benefits and
 harms of using antithrombotic drugs for prevention of ischaemic events in patients who have
 had an ICH.

 There are only observational studies addressing this question. Because of the lack of
 randomised-controlled trials and the inconclusive findings of the observational studies,
 guidelines have variably endorsed both starting and avoiding antithrombotic drugs after ICH.

 The investigators therefore want to study the effect and safety of using antithrombotic drugs
 after ICH. Furthermore, since findings on MRI can be biomarkers for subsequent bleeding,
 there will also be performed a sub-study of the association between such findings on MRI and
 risk of recurrent ICH during treatment with antithrombotic drugs.

 Patients with ICH during the last 6 months and with an indication for antithrombotic drugs
 will be included. Patients with vascular disease and indication for antiplatelet drugs will
 be randomised to antiplatelet treatment vs. no antithrombotic treatment. Patients with atrial
 fibrillation and indication for anticoagulant treatment will be randomised to anticoagulant
 treatment vs. no anticoagulant treatment. The follow up period is 2 years, and the primary
 effect variable is new ICH. The investigators will also assess new intracranial haemorrhage,
 extracranial haemorrhage and ischemic events, and functional and cognitive outcome.
Inclusion Criteria:

 -  Patient age ≥18 years.

 -  Spontaneous, primary ICH, of ≥1 day, but not more than 180 days after onset of
 qualifying ICH, i.e.:

 -  No preceding traumatic brain injury, based on history from the patient/witness of
 spontaneous symptom onset, and brain imaging appearances consistent of
 spontaneous ICH (i.e. any brain/bone/soft tissue appearances of trauma must have
 occurred secondary to a spontaneous ICH)

 -  No 'secondary' or underlying structural cause (e.g. haemorrhagic transformation
 of an ischaemic stroke, aneurysm, tumour, arteriovenous malformation, or
 intracerebral venous thrombosis)

 -  Patient have indication for antithrombotic (i.e. anticoagulant or antiplatelet) drug
 for the prevention of ischaemic events, either antiplatelet drugs (for patients with
 vascular disease), or anticoagulant drug for patients with atrial fibrillation.

 -  Consent to randomisation from the patient (or personal / legal / professional
 representative if the patient does not have mental capacity).

 -  MRI (or CT) is performed before randomisation.

 Exclusion Criteria:

 -  Clear indication for antiplatelet or anticoagulant treatment (e.g. prosthetic heart
 valves).

 -  Contraindications to the antithrombotic drug that will be administered.

 -  Patient is pregnant, breastfeeding, or of childbearing age and not taking
 contraception.

 -  For patients examined with MRI: Contraindication for brain MRI

 -  Malignancy with life expectancy less than 2 years