A Pilot Study Into Health Pre and Post Treatment With Intravenous Aminophylline and Hydrocortisone in Severe Asthmatics
A Pilot Study Into Health Pre and Post Treatment With Intravenous Aminophylline and Hydrocortisone in Severe Asthmatics
This study focuses on severe asthmatics and their asthma symptoms. 40% of asthma patients
 continue to experience symptoms and up to 5% of these have difficult-to-control asthma
 despite continually improving treatments. Severe asthmatics experience clinically-significant
 worse health-related quality of life than those than those with less severe asthma. Poorer
 health-related quality of life can be as a consequence of frequent, severe symptoms, which
 prevent the patient from continuing a normal, active lifestyle. The Royal Brompton Hospital
 uses the treatment regimen of intravenous (IV) Aminophylline and IV Hydrocortisone which
 appears to improve symptoms and reduce exacerbations. At present there is anecdotal evidence
 to support these assumptions. The objective of this study is to determine whether there is
 any objective evidence of improvement, in particular looking at lung function, symptoms and
 cardiovascular function.
The participant will be involved in this project for approximately 3 - 4 weeks, depending on
 how long they usually come into hospital for, for clinical treatment. For 1 week they will
 wear a physical activity monitor before the first course of Aminophylline and Hydrocortisone,
 during the treatment, and for 1 more week post treatment. This monitor records how active the
 participants are and is a small monitor worn on the upper arm.

 Both study visits will happen while the patients are already in hospital, on admission and on
 discharge and will take approximately 2-3 hours to complete.

 Both study visits include:

 • 3 types of breathing tests: Impulse oscillometry in the asthma laboratory, which means they
 will breath through a mouth piece in and out at a comfortable, steady rate.

 Exhaled nitric oxide which measures gas produced by cells in the lungs. This is a
 comfortable, steady blow into a handheld machine.

 Spirometry which involves filling the lungs and blowing out hard into a machine.

 -  A blood test - Full Blood Count (FBC) including eosinophils, glucose, fibrinogen,
 C-Reactive Protein (CRP), total Immunoglobulin-E (IgE), citrate coagulation and platelet
 aggregation.

 -  3 short questionnaires which ask about symptoms, control of asthma, and how the patient
 feels asthma affects them.

 -  A 6 Minute Walk Test which involves walking up and down a ward corridor for 6 minutes to
 see distance covered in 6 minutes.

 -  Cardiovascular test:

 Arterial stiffness which is a series of blood pressures on the leg, arm and neck.

 Some of these tests will be performed as part of their usual hospital care. These include
 blood test, 6 Minute Walk Test, and spirometry.

 Blood samples will be done routinely as part of normal care. Blood will only be collected if
 they do not have a clinical blood test before the administration of IV Aminophylline and IV
 Hydrocortisone and after the final dose. The clinical trial is observing patients on a
 clinical treatment. All decisions regarding the treatment dose and duration will be made by
 the clinical team. All samples will go to the standard accredited hospital routine laboratory
 on the trial site. No samples will be stored, moved off site or leave the UK.
Inclusion Criteria:

 1. Age 18-65 years

 2. Diagnosis of severe asthma

 3. Confirmed therapy adherence via serum Prednisolone and cortisol levels

 Exclusion Criteria:

 1. Mild and moderate asthma

 2. Community acquired pneumonia

 3. Acute porphyria

 4. Pregnant and breast feeding women

 5. Patients hypersensitive to ethylenediamine or allergic to the theophyllines, caffeine
 and/or theorbromine.

 6. Patient with known hypersensitivity to components and in systemic fungal infection

 7. Patients that are being administered live attenuated vaccines.