Role of the Environment and Endocrine Disruptors in Child Cryptorchidism
Role of the Environment and Endocrine Disruptors in Child Cryptorchidism
Cryptorchidism is the most frequent congenital defect of the male newborn. It requires
 surgery in childhood, increases the risk of fertility disorders and cancer. As a major public
 health objective, it's the subject of numerous recommendations. Its frequency is increasing
 in some countries faster than a single genetic cause could not explain it. It may occurs in a
 geographic cluster. The cause of cryptorchidism involves genetic, hormonal and environmental
 factors. Animal studies suggest that endocrine disruptors interfere with fetal testicular
 migration. The aim of the study is to find out if some environmental exposition may be
 associated with cryptorchidism.
Cryptorchidism is the most frequent congenital defect of the male newborn. It requires
 surgery in childhood, increases the risk of fertility disorders and cancer. As a major public
 health objective, it's the subject of numerous recommendations. Its frequency is increasing
 in some countries faster than a single genetic cause could not explain it. It may occurs in a
 geographic cluster. The cause of cryptorchidism involves genetic, hormonal and environmental
 factors. Animal studies suggest that endocrine disruptors interfere with fetal testicular
 migration. The aim of the study is to find out if some environmental exposition may be
 associated with cryptorchidism.
Inclusion criteria:

 - Parents of male children from the neonatal period to 18 years of age (during surgery)
 with cryptorchidism

 Exclusion criteria:

 -  Parents of children without endocrine disease. (adrenal, hypothalamic-pituitary,
 phosphocalcic, thyroid, diabetes, etc.)

 -  Parents of children without an associated genital or urinary defect (hypospadias,
 micropenis, renal and bladder abnormalities)

 -  Testicular Ectopia (testis outside of normal migration path)

 -  Anorchidism and evanescent testicles, united or bilateral

 -  Abnormalities of the abdominal wall (laparoschisis, omphalocele, Prune Belly)

 -  Cryptorchidism integrating in the context of a polymalformative syndrome, including
 neurological.