Study of Blood Clotting After Transcatheter Atrial Septal Defect Closure
Study of Blood Clotting After Transcatheter Atrial Septal Defect Closure
The purpose of this study is to evaluate blood clots after Percutaneous ASD Closure in
 different age, sexuality and defective diameter; evaluating the relationship of blood
 clotting with Occluder, injury of intima and inflammation;comparation of the effect and
 safety between different anticoagulation after Percutaneous ASD Repair; explore propose an
 optimal anticoagulation plan.
Atrial septal defect (ASD) is a common clinical congenital heart disease. It is estimated
 that the congenital heart disease increase in children by about 15 million annual in China ,
 of which ASD accounted for 10% to 15%. Secundum ASD is the most common clinical type of ASD,
 of which about 70% is suited to tanscatheter close.With the cardiac catheterization advancing
 and the devices developing in recent years ,the method has gradually replaced open-chest
 surgical repair to the person with Secundum ASD. At present, the most widely used device is
 Amplatzer occluder. With the wide ues of the occlur,there has gradually emerged occluder
 thrombosis after closure.there are much different methods to antiplatelet and
 anticoagulation，not only in China but also in the world.so we perfom the study to evaluating
 the blood clotting after Percutaneous ASD Closure in different age, sexuality and defective
 diameter; evaluating the relationship of blood clotting with Occluder, injury of intima and
 inflammation;comparation of the effect and safety between different anticoagulation after
 Percutaneous ASD Repair; explore propose an optimal anticoagulation plan.
Inclusion Criteria:

 -  Age≥3 years

 -  Diameter of defect≥5mm and increasing volume load of right heart

 -  ≤36 mm secondary left to right shunt

 -  The distance between defective edge and coronaria venosus sinus, inferior caval vein,
 superior vena and pulmonary vein≥ 5 mm, between artrial-ventricular valve≥7 mm

 -  The diameter of defect>Occluder

 -  No other cardiac anomalies need surgery intervention

 Exclusion Criteria:

 -  Hypertension

 -  Coronary artery disease

 -  Diabetes

 -  Atrial fibrillation and oral contraceptive medication

 -  Aspro, clopidogrel and warfarin in 2 weeks.