Effectiveness Of Single Doses Of Ibuprofen In Patients With Osteoarthritis Of The Knee
Effectiveness Of Single Doses Of Ibuprofen In Patients With Osteoarthritis Of The Knee
To demonstrate that new drugs work, many complex multidose studies are often required. The
 intent of this study is to use Ibuprofen as an example of a marketed pain relief drug to
 validate a simpler single dose model for future assessment of new pain drugs.
Inclusion criteria:

 -  Subjects diagnosed with primary Osteoarthritis of the knee.

 -  Have at least 3 months in symptom duration prior to screening visit.

 -  Regular user of a prescribed non-steroidal anti-inflammatory drug (NSAID) or selective
 cyclo-oxygenase II (COX2) inhibitor for management of knee pain.

 -  Pain walking on flat surface within specific interval prior to study start.

 Exclusion criteria:

 -  History of hypersensitivity to NSAIDS.

 -  Allergy to Ibuprofen.

 -  Use of assistive devices other than a cane or knee brace.

 -  History of specified diseases/illnesses.

 -  Abnormal blood tests pre-study.