Analgesic Efficacy of Intravenous Ibuprofen in Biliary Colic
Analgesic Efficacy of Intravenous Ibuprofen in Biliary Colic
The aim of this study is to assess the analgesic efficacy of intravenous ibuprofen given in
 the Emergency Department for the treatment of biliary colic. We hypothesize that intravenous
 ibuprofen will provide a clinically significant drop in self-reported patient pain level as
 measured by the visual analog scale.
It is estimated over 20 million people aged 20-74 have gallbladder disease, with biliary
 colic being a common and painful symptom in these patients. Likely due to the relatively
 recent approval of intravenous ibuprofen use for fever and pain in adults, no assessment of
 its analgesic efficacy for biliary colic currently exists in the literature.

 Utilizing a visual analog scale (VAS) for patient self-assessment of pain, this study will
 address this lack of evidence and identify intravenous ibuprofen's value as a novel analgesic
 in the treatment of biliary colic. Patients will be given a VAS at the time of study therapy
 administration, at 15-minute intervals during the first hour post-administration, and
 30-minute intervals in the second hour. Though NSAID's have been extensively studied in the
 management of this phenomenon, this study aims to help optimize pain treatment of patients
 presenting to the Emergency Department with biliary colic, and potentially pave the way for
 future analgesic treatment comparison studies.
Inclusion Criteria:

 -  Patients ages 18-55

 -  Present to ED with right upper quadrant (RUQ) abdominal pain

 -  Suspected diagnosis of biliary colic

 -  Negative pregnancy test for women of childbearing potential (complete POC testing
 form)

 -  No history of cholecystectomy

 Exclusion Criteria:

 -  Patient age < 18 or > 55

 -  Incarcerated

 -  Hemodynamic instability

 -  Inability to reliably self-report or communicate pain intensity and pain relief

 -  Taking Warfarin

 -  Cannot consent of are not competent to consent

 -  Hepatic, renal, cardiac failure

 -  NSAID or morphine allergy

 -  History congenital bleeding diathesis or platelet dysfunction

 -  Peptic ulcer diseases

 -  Are otherwise unsuitable for the study in the opinion of the
 investigator/sub-investigators