A Study of TG103 in Subjects With Type 2 Diabetes
A Study of TG103 in Subjects With Type 2 Diabetes
The main purpose of this study is to assess the safety and tolerability of multiple ascending
 doses of TG103 in subjects with type 2 diabetes.
This study is a randomized, double-blind, placebo-controlled, multicenter, dose-escalating
 study to characterize the safety (including the anti-drug antibodies(ADA)), tolerability
 pharmacokinetics (PK) and pharmacodynamic parameters（PD）of TG103. The study will consist of 3
 periods: an approximately 2-week lead-in period, followed by a 12-week treatment period, and
 a 3-week safety follow-up period. Three dose groups (7.5mg, 15mg and 22.5mg) of subjects will
 be enrolled and dosed sequentially; 12
Inclusion Criteria:

 -  1. Subjects who fully understand the test content and possible adverse reactions and
 voluntarily participate in the trial and sign the informed consent form;

 -  2.Age: 18 to 75 years of age inclusive; no gender limitation;

 -  3. Weight：body mass index (BMI) within the range of 18.5-35 kg/m2 (inclusive), BMI =
 weight (kg) / height 2 (m2);

 -  4. Patients have diagnosed with type 2 diabetes ≤ 3 years according to the World
 Health Organization (WHO1999) classification; and not on medication or without a
 history of regular medication for more than 1 week in the 3 months prior to screening
 (subjects with a history of medication only include those with a history of oral
 medication and a history of short-term intensive insulin therapy (≤ 2 weeks));

 -  5. 7.0% ≤ HbA1c ≤ 10.0%;

 -  6. Subjects of childbearing potential must use reliable methods of contraception from
 the date of signing an informed consent to at least 3 months after the last dose;

 -  7. The subject has the ability to communicate properly with the researcher and willing
 to fully comply with the research protocol.

 Exclusion Criteria:

 -  1. Fasting plasma glucose ≥13.9mmol/L or a history of severe hypoglycemia (blood sugar
 below 2.2mmol/L);

 -  2. Systolic blood pressure ≥160 mmHg or diastolic blood pressure ≥100 mmHg during
 screening;

 -  3. During the screening period, the white blood cell count fall outside the reference
 range by 10%, or hemoglobin<100g / L;

 -  4. Have one or more positive tests in Hepatitis B surface antigen, hepatitis C virus
 antibody, anti-human immunodeficiency virus antibody or anti- Treponema
 pallidum-specific antibody;

 -  5. Aspartate aminotransferase(AST) or Alanine aminotransferase (ALT) > 2.5x upper
 limit of normal (ULN), or triglyceride > 5.7mmol/L or eGFR<60 mL/（min*1.73 m2）during
 the screening period;

 -  6. Hypercortisolism, polycystic ovary syndrome, abnormal thyroid function (those who
 need to be given medication or who have not reached clinical stability after treatment
 and whose medication still needs to be adjusted), etc. or other diseases that may
 affect blood glucose metabolism.

 -  7. Have a personal or family history of medullary thyroid carcinoma (MTC) or type 2
 multiple endocrine neoplasia, or other genetic diseases that are susceptible to
 medullary cancer; personal or family history of medullary thyroid carcinoma (MTC) or
 type 2 multiple endocrine neoplasia, or other genetic diseases that are susceptible to
 medullary cancer;

 -  8. Acute complications of diabetes (including diabetic ketoacidosis, hyperosmolar
 nonketotic diabetic coma, lactic acidosis and hypoglycemia coma);

 -  9. Proliferative diabetic retinopathy, foot ulcers/gangrene, and manifestations of
 peripheral neuropathy with obvious symptoms (e.g., gastroparesis, urinary retention,
 intestinal obstruction, urinary incontinence, and painful peripheral neuropathy);

 -  10. Lost more than 400 ml of blood due to blood donation or other reasons within 3
 months before the screening period;

 -  11. During 3 months prior to screening through the entire study period, subjects used
 or plan to use drugs that may affect blood glucose metabolism or directly reduce
 gastrointestinal motility (e.g., anticholinergic drugs, antispasmodic, 5-HT3
 antagonists, dopamine antagonists, and opioids), or oral and intramuscular injections
 of systemic corticosteroids, or inhalation or intranasal use of potent steroidal drugs
 with high systemic absorption; subjects regularly used thiazide diuretics within the 3
 months prior to screening (Continuous medication > 1 week), or will use high doses of
 thiazide diuretics during the study period (hydrochlorothiazide>100 mg/d,
 chlorothiazide> 2 g/d, indapamide> 5 mg/d, chlorthalidone> 100 mg/d);

 -  12. During the screening period, subjects with second degree or third degree
 atrioventricular block (except for subjects who use the pacemaker), long QT syndrome
 or prolonged QTc interval (male>450ms, female>470ms), or those with significant
 clinical symptoms of ischemic heart disease; or those with other heart diseases that
 are judged by the investigator to be unsuitable for entry into the study;

 -  13. Any of the following cardiovascular and cerebrovascular events within half a year
 before screening: unstable angina pectoris requiring hospitalization, myocardial
 infarction, coronary artery bypass grafting, percutaneous coronary intervention
 (diagnostic angiography is allowed), moderate to severe congestive heart failure (NYHA
 grade III or IV), atrial or ventricular arrhythmia requiring hospitalization (such as
 atrial fibrillation and ventricular tachycardia). Subjects with pacemaker or
 defibrillator implantation, transient ischemic attack or cerebrovascular accident
 (e.g. stroke), or those with coronary artery bypass grafting or revascularization
 planned during the study period;

 -  14. Have chronic or acute pancreatitis ( or have a history of chronic pancreatitis or
 acute pancreatitis) or severe gastrointestinal disease, such as confirmed reflux
 esophagitis or gallbladder disease, or any impact on gastric emptying (such as gastric
 bypass surgery, pyloric stenosis, except for appendectomy) or gastrointestinal
 diseases that may be aggravated by GLP-1 analogues; for patients with a history of
 gallbladder stones (gallstone removal or lithotripsy) and/or cholecystectomy, if there
 are no further sequelae, the entering of the study will be determined by researchers
 after assessing the risk;

 -  15.Have a history of severe respiratory, blood system, and central nervous system
 (e.g. epilepsy) diseases; or have a history of malignant tumors or mental illnesses
 (such as depression, anxiety, etc.); or have other medical conditions that may
 endanger the safety of the subject and the investigator believes it is not suitable
 for inclusion;

 -  16. Have had undergone major surgery within 3 months before screening, or had ongoing
 severe or acute infection within 4 weeks before screening;

 -  17. Have a serious history of drug or food allergy, or may be allergic to the
 investigational product according to the judgment of the researcher;

 -  18. Have taken prescription or over-the-counter medications for weight loss (e.g.,
 orlistat, sibutramine, rimonabant, phenylpropanolamine, or chlorambucil) within 3
 months prior to screening; or have undergone surgery that can cause weight
 instability; or have had a significant change in weight (>10% change);

 -  19. Average alcohol intake is more than 21 units of alcohol (male)/14 units of alcohol
 (female) per week (1 unit ≈ 360mL beer, or 45mL spirits with 40% alcohol content, or
 150mL wine) within the 3 months prior to screening;

 -  20. Regularly consumption of caffeine is more than 600 mg of per day within the 3
 months prior to screening (1 cup of coffee contains about 100 mg of caffeine, 1 cup of
 tea contains about 30 mg of caffeine, and 1 can of cola contains about 20 mg of
 caffeine);

 -  21. Smoke more than 20 cigarettes per day within 3 months prior to screening;

 -  22. Have skin abnormalities (such as: dermatitis) within a radius of 2cm of the
 administration site;

 -  23.Participated in other clinical trial involving an investigational product within 3
 months before the screening and the time of the last dose of the study drug is less
 than 3 months before the screening of this trial; or subjects withdrawn from the
 previous study due to an adverse event; or plan to participate other clinical trial
 during the study period;

 -  24. Pregnant (blood pregnancy test positive in screening period) and lactating female;

 -  25. Not suitable for this study in the researcher's opinion.