Benefit of Pharyngeal and Oesophageal pH-impedance of Patients With High Suspicion of Laryngopharyngeal Reflux
Benefit of Pharyngeal and Oesophageal pH-impedance of Patients With High Suspicion of Laryngopharyngeal Reflux
Laryngopharyngeal reflux (LPR) is the retrograde movement of gastric contents into the
 larynx, pharynx and upper aerodigestive tract. The symptoms and manifestations are very
 changeable and non specific. Pharyngeal and Oesophageal pH-impedance may help to detect these
 reflux and to identify patients with abnormal LPR.

 To compare and describe the results of pharyngeal and oesophageal pH-impedance of patients
 with high suspicion of laryngopharyngeal reflux, with the results of healthy patients.
This is a monocentric, prospective descriptive study. Patients will be recruited in
 otolaryngology and gastroenterology departments of Bordeaux teaching hospital. A first
 clinical, endoscopic and pH-impedance evaluation will be made, after at least 15 days of
 interruption of any proton pump inhibitors (PPI). After 8 weeks' treatment by double PPI
 doses (esomeprazole 40 mg bid), another clinical and pH-impedance evaluation will be
 realized. The characteristics of the patients who respond to the treatment will be compared
 to non responders. The subjects will also have an initial laryngoscopy, an oesophageal
 manometry allowing the location of the lower sphincter of the oesophagus and the upper
 sphincter of the oesophagus for positioning the catheters.
Inclusion Criteria:

 -  age : 18 to 80 years old.

 -  Written consent

 -  Laryngopharyngeal symptoms (dysphonia, and/or globus and/or sensation, and/or
 pharyngeal pain, and/or cough) for 3 months at least.

 -  No PPI for at least 15 days

 -  Social security affiliation

 Exclusion Criteria:

 -  Sinusitis or chronic rhinitis (in the previous year)

 -  Laryngeal trauma, tracheotomy or pharyngolaryngeal surgery

 -  pregnancy or absence of efficacy contraception

 -  breast feeding

 -  history of gastrointestinal pathology, diabetes, neurological condition

 -  cardio-vascular history requiring the taking of Plavix

 -  esomeprazole contraindication or intolerance