Home Stimulation for Brain-Asphyxiated Infants
Home Stimulation for Brain-Asphyxiated Infants
This study examines the potential benefits of a home stimulation program to treat infants who
 have suffered from brain asphyxiation (lack of oxygen). The program involves one year of
 stimulatory activities. Progress will be evaluated through neurological and behavioral exams.
Although the incidence of brain injury in infants is only 2 to 5 per 1000 births, the legal
 and medical costs, the developmental delays, and the impact on the family are profound.
 Twenty to 30% of survivors of brain injury have some long-term neurologic sequelae.

 This randomized controlled trial will enroll 120 term and near-term neonates with a history
 of asphyxia to 1-year of a standard follow-up program (provided by the Los Angeles Regional
 Centers) or a home-based intervention program (Utah State University's Developmental
 Curriculum and Monitoring System, CAMS). The experimental intervention will include
 individualized cognitive/neuromotor stimulation given by the child's parents under the
 guidance of public health nurses. Following the intervention, measures will be used to
 determine functional capacity (Bayley II scale and neurologic examination), behavioral
 outcomes (HOME and NCAST by developmental specialists), and maternal outcomes (including
 parent-infant interaction and perceived stress). Infants will be assessed after the 1-year
 intervention by psychologists and physicians masked to the intervention. Functional MRI brain
 studies will be conducted at discharge and 18 months of age at UCLA to assess qualitative and
 quantitative sensorimotor representation. Secondary outcomes include care stress and social
 support as reported by parents, and demographics and medical factors obtained from the
 hospital records.
Inclusion Criteria

 All of the following criteria must be met:

 -  Gestation age (GA) at birth >= 28 weeks

 -  Discharged to home care with parent or other guardian who has legal authority to give
 informed consent

 -  Greater than 10th percentile for GA at birth using the scales according to Lubchenco,
 Hansman, and Boyd from Pediatrics 1966 volume 37 and Battaglia and Lubchenco in the
 Journal of Pediatrics 1967 volume 71

 -  Jewelry in pierced body parts can be removed

 -  Mothers > 17 years old

 -  Recruited within 60 days of EDC (estimated date of conception)

 Two or more of the following must be met:

 -  Intrapartum distress as determined by placental abruption, thick meconium staining of
 amniotic fluid, sustained fetal bradycardia of heart rate < 100 beats/min, or late or
 absent heart rate variability

 -  Profound metabolic or mixed academia as determined by umbilical artery pH < 7.0, base
 deficit of > 10 mEq/L or pH < 7.1 and base excess greater than 14 mmol/L within 72
 hours of birth, Apgar score < 5 at 5 minutes or beyond, or need for positive pressure
 ventilation resuscitation for > 1 min after birth

 -  Neonatal neurological manifestations such as seizures during hospital stay, lethargy,
 hypotonia or hypertonia, stupor, flaccidity, or decerebration

 -  Multiple organ system dysfunction

 -  Abnormal EEG, CT scan, or MRI consistent with hypoxic or ischemic brain insult

 Exclusion Criteria:

 -  Infants of substance abusing mothers (ISAM)

 -  Intrauterine growth retardation (IUGR)

 -  Infants requiring extracorporeal membrane oxygenation (ECMO) in the neonatal period

 -  Hearing or visual impairment

 -  Congenital cyanotic heart disease with cyanosis and requiring PGE infusion. Children
 with minimum cardiac structural anomalies (e.g., PDA or VSD or peripheral pulmonary
 stenosis) will not be excluded from the study.

 -  Congenital abnormalities of the central nervous system such as congenital
 hydrocephalus

 -  Grade IV intraventicular hemorrhage requiring ventriculo-peritoneal shunt (VP shunt)

 -  Trisomy 13, 18, or 21, or Fragile X

 -  Metabolic encephalopathy from inborn errors of metabolism (e.g. PKU, OTC)

 -  Metal or wire mesh implants, pacemaker implants, cochlear implants, orthopedic
 surgical wires or implants

 -  Status epilepticus

 -  Ventilator dependent at discharge

 -  Infectious meningitis

 -  Encephalitis with radiological evidence of severe cortical or severe hemispheric
 destruction

 -  Silastic catheters, broviacs, or Hickman port home TPA

 -  Infants who may not be available for the duration of the study

 -  Any infant who in the opinion of investigator has no potential to benefit from the
 intervention (e.g., children with prenatal herpes meningitis, severe cortical
 destruction, mother does not follow up with the intervention or with the follow-up
 appointments)