Non-Inferiority Study to Compare the Effectiveness of the Seldinger Over-the-Wire Technique and the Modified Seldinger Technique
Non-Inferiority Study to Compare the Effectiveness of the Seldinger Over-the-Wire Technique and the Modified Seldinger Technique
Peripherally inserted central venous catheter lines (PICC-line) are successfully used since
 many years in patients who need long-term frequent IV therapy. The PICC placement is
 performed under fluoroscopy The study objective is to compare the effectiveness and safety of
 the Seldinger wire technique (over-the-wire) using a 145 cm guidewire with the modified
 Seldinger technique using a 70 cm guidewire.
The referral of patients with indication to PICC-line implantation at the institute of
 diagnostic and interventional radiology occurs through different departments of the
 University Hospital Jena. The patients are registered for radiological treatment and checked
 again by a radiologist if a PICC-line implantation is indicated. If this is the case, the
 radiologist conducts an informed consent discussion with the patient about possible
 complications and risks during intervention and informs him also about a possible study
 participation. After signature of the written informed consent, the patient is included. He
 can, at any time, withdraw his consent. On the intervention day, the patient is randomly
 assigned to one of the two study arms through envelope (145 cm vs 70 cm). The intervention
 time is documented. After intervention, the patient is transferred back to the ward or sent
 home. The examination of the puncture site before discharge is performed by a ward physician
 or by the family doctor.

 Within 2 weeks after PICC-line implantation, the treating physician is contacted and
 questioned about possible complications (catheter occlusion, haematoma, infection of the
 puncture site, arm vein thrombosis, pain, etc.), that are then thoroughly documented.
Inclusion Criteria:

 -  female, male

 -  adults ≥ 18 years

 -  medical indication for Power-PICC-Line catheter implantation because of chemotherapy
 or parenertal nutrition

 -  in- and outpatients

 Exclusion Criteria:

 -  age < 18 years

 -  systemic infection

 -  local infection of the interventional location

 -  known allergy to used material

 -  general contraindication of Power-PICC-Line catheter implantation