Tolerability of Metoprolol-Succinate-ER and Carvedilol in COPD
Tolerability of Metoprolol-Succinate-ER and Carvedilol in COPD
Use of beta-blockers has proven beneficial in patients with hypertension, heart failure, and
 in people who have suffered a heart attack. The use in patients who have Chronic Obstructive
 Pulmonary Disease (COPD) and reactive airway disease, however, has been limited due to
 possible side effects such as worsening of lung function or increasing airway spasms and
 asthma attacks. The purpose of this study is to find out if patients with COPD can tolerate
 being on a beta-blocker at doses recommended for the treatment of heart disease conditions.
 This study also seeks to find out if a selective beta-1 receptor beta-blocker is better than
 a non-selective beta-blocker in patients with mild to moderate COPD.
Inclusion Criteria:

 -  40 years of age or older

 -  Mild to moderate COPD as defined by the American Thoracic Society

 -  Current treatment with a beta-blocker for either hypertension, myocardial infarction,
 or congestive heart failure.

 Exclusion Criteria:

 -  Recent (within 30 days) COPD exacerbation or requirement for oral steroid therapy
 within the last 6 months

 -  Any history of ventilator support requirement for COPD

 -  Patients with asthma or reactive airway disease (RAD) defined as obstructive lung
 disease with a >15% improvement in FEV1 with beta-agonist therapy

 -  Relative or absolute contraindication to beta-blocker therapy

 -  Exposure to any investigational drugs within the previous 30 days

 -  Patients with any concurrent disease or condition, which in the judgment of the
 investigator would make the patient inappropriate for participation in the study were
 excluded from this study