Evaluating an Emergency Department Observation Syncope Protocol for Older Adults
Evaluating an Emergency Department Observation Syncope Protocol for Older Adults
Syncope, defined as a transient loss of consciousness, accounts for over 700,000 annual U.S.
 emergency department visits and may herald a life-threatening condition in older adults
 (age≥60 years). Existing risk prediction instruments cannot reliably identify who among such
 older patients can safely be discharged home from an emergency department. As a result, the
 majority of older patients without a clear cause for syncope are hospitalized for diagnostic
 evaluation. However, current admission practices are characterized by low diagnostic yield,
 do not clearly improve outcomes, and account for over $2.4 billion in annual hospital costs.
 Most admitted patients are discharged within 48 hours, and approximately 50% of patients do
 not have an identified cause of syncope after their hospitalization.

 The implementation of an expedited and standardized Emergency Department Observation Syncope
 Protocol (EDOSP) may safely reduce hospitalization of older patients with syncope. The
 investigators propose a pilot randomized trial to implement and evaluate EDOSP at two
 emergency departments. This study has the following exploratory Specific Aims:

 1. To compare admission rates and length-of-stay associated with EDOSP to standard care.

 2. To compare serious outcomes rates associated with EDOSP to standard care.

 3. To compare quality-of-life associated with EDOSP to standard care.

 4. To compare the incremental costs and cost-effectiveness of EDOSP to standard care.

 Over a one-year period, 120 intermediate-risk older adults who present with syncope at the
 two study sites will be randomized to 1 of 2 arms: 1.) intervention arm: expedited and
 standardized EDOSP care; or 2.) control arm: routine care consisting of admission from the
 emergency department.

 If this pilot trial suggests that EDOSP can safely reduce admissions, then the investigators
 will plan a larger study powered to evaluate clinical, quality-of-life, and economic
 outcomes. A successful EDOSP intervention would have important clinical policy implications
 and improve the emergency department care of older adults with syncope.
Inclusion Criteria:

 -  Age≥60 years

 -  A complaint of syncope or near-syncope (Syncope is defined as a sudden, transient loss
 of consciousness. Near-syncope is defined as a sensation of imminent loss of
 consciousness, without actual syncope.)

 -  Intermediate risk of adverse outcome (see Table)

 -  Patient speaks either English or Spanish as a primary language.

 Exclusion Criteria:

 -  Syncope mimics (intoxication, weakness or dizziness with syncope/ near-syncope,
 hypoglycemia, and cardiac arrest)

 -  New or baseline cognitive impairment or dementia)

 -  Inability to provide follow-up information (e.g. homeless or resides outside of U.S.)

 -  Inability to speak Spanish or English

 -  Low- and high-risk patients (see Table).

 Risk Stratification Guidelines:

 -  High Risk

 -  Serious condition identified in ED

 -  History of ventricular arrhythmia

 -  Cardiac Device with dysfunction

 -  Presentation consistent with acute coronary ischemia

 Intermediate Risk

 -  No High Risk features

 -  Presentation not consistent with orthostatic or vasovagal syncope

 Low Risk

 -  Presentation consistent with orthostatic or vasovagal syncope