Effects of THW and rhTSH in Glomerular Filtration Rate During RIT
Effects of THW and rhTSH in Glomerular Filtration Rate During RIT
To observe the influence of thyroid hormone withdrawal and of recombinant human TSH during
 radioiodine therapy in renal function.
Radioiodine therapy in thyroid carcinoma is a procedure performed for over six decades, and
 there is a vast literature in respect of its value in the complementary treatment of this
 neoplasia. This procedure also promotes a reliable follow-up based on sequential
 thyroglobulin dosages and makes possible to reduce the disease recurrence rate. One of the
 main aspects of the patients preparation before receiving the radioiodine consists in
 promoting stimulation for an effective uptake of the radioiodine, obtained either by
 endogenously TSH level elevation after post-surgical thyroid hormone withdrawal, or
 exogenously after use of recombinant human TSH. This last alternative does not demand
 suspension of thyroid hormone reposition after total thyroidectomy. Although not fully
 comprehended, it is known that hypothyroidism results in renal function hazard, which is
 reverted after hormonal reposition. It is also known that renal function modifies the
 radioiodine residence time and that the longer this time, the greater the patient's radiation
 exposure will be, and consequently with undesired irradiation of healthy tissues and organs.
 So theoretically stimulating the patient with recombinant human TSH could avoid the transient
 deficient renal function, promoting a lower radioiodine residence time and consequently
 lowering radiation exposure in this therapy.

 This project aims to evaluate the effects of the different stimulation, endogenous and
 exogenous, over renal function by glomerular filtration rate determined by 51Cr-EDTA. This
 will be a controlled and randomized study in which 44 patients that has clinical indication
 of remnant ablative radioiodine treatment will be prepared by either one of the TSH
 stimulation procedures. Additionally radiation dosimetry calculus will be done to analyze the
 levels of the patient's radiation exposure associated with each of the uptake stimulation
 procedures for radioiodine therapy.
Inclusion Criteria:

 -  Normal Renal Function

 Exclusion Criteria:

 -  Abnormal Renal Function

 -  Renal metastasis