Comparative Study Between Tadalafil Versus Tamsulosin as a Medical Expulsive Therapy for Lower Ureteric Stones
Comparative Study Between Tadalafil Versus Tamsulosin as a Medical Expulsive Therapy for Lower Ureteric Stones
The aim of the work is to compare the efficacy of tadalafil and tamsulosin as a medical
 expulsive therapy for lower ureteric stones
Gradually increasing incidence rate of kidney stone is a significant concern of medical
 world. Genetics and/or life style accelerate the kidney stone formation (Urolithiasis).
 Sometimes, it is stuck up in ureter especially distal ureter; hence called as lower ureteral
 stone (LUS) and causes intense flank pain beside urinary obstruction.

 The ureter contains α adrenergic receptors along its entire length with the highest
 concentration in the distal ureter.

 There has been a steep rise in minimally invasive procedures but medical expulsive therapy
 (MET) is still regarded as an established treatment option for the management of distal
 ureteric stones.

 Stone location, size, number, ureteric spasm, mucosal oedema or inflammation, and ureteric
 anatomy are the factors affecting passage of ureteric stones.

 Drugs that expel stones might act by relaxing ureteral smooth muscle through inhibition of
 calcium channel pumps or α-1 receptor blockade. Tamsulosin is one of the most commonly used
 α-blockers.

 Phosphodiesterase inhibitors (PDEi) are a class of drugs that inhibit the breakdown of cAMP
 and cGMP, enhancing smooth muscle relaxation. Therefore, PDEi may be able to decrease
 ureteral spasm and facilitate stone passage. Tadalafil is a selective PDE5i and because of
 its smooth muscle relaxation property, tadalafil received the US Food and Drug Administration
 approval for lower urinary tract symptoms with benign prostatic hyperplasia and erectile
 dysfunction.

 Monotherapy with tadalafil or tamsulosin similarly improved lower urinary tract symptoms had
 already been demonstrated .

 With demonstration of in vitro effects of phosphodiesterase-5 inhibitor (PDE5i) as tadalafil
 on isolated human ureteral smooth muscle, interest in use of PDE5i as MET has increased.
Inclusion Criteria:

 -  Patients aged ≥18 years

 -  Patient have a distal ureteric stone of 5-9 mm in greatest dimension

 -  Patient diagnosed by ultrasonography of the kidney, ureter, and bladder , X-ray KUB
 and noncontrast computed tomography scan.

 Exclusion Criteria:

 -  Pregnant or lactating mothers.

 -  Patients have UTI.

 -  Patients have severe hydroureteronephrosis.

 -  Patients have multiple ureteric stones.

 -  Patients have solitary kidney.

 -  Patients have acute or chronic renal failure.

 -  Patients have previous therapies for the stone.

 -  Patients with history of open surgery/endoscopic interventions.

 -  Patients have ureteric strictures.

 -  Patients take concomitant treatment with calcium antagonists, β-blockers,
 corticosteroids or nitrates.