Association of Tumour Grade and Sex Steroid Receptor as a Prognostic Index in Breast Cancer
Association of Tumour Grade and Sex Steroid Receptor as a Prognostic Index in Breast Cancer
Null hypothesis: Histological grade of tumour bears no relation with the status of sex
 hormone receptors.

 Alternate hypothesis: Both the histological grade of tumour and expression of sex steroid
 receptors are directly related to each other The investigators aim to;

 1. see the relationship of sex steroid receptors with the histological grade of breast
 cancer.

 2. evaluate the efficacy of steroid receptors as a prognostic factor
Breast cancer accounts for the largest number of deaths amongst the female population
 worldwide. It is now considered as a systemic disease even if diagnosed at an initial stage,
 as the clinical behaviour cannot be accurately predicted. Due to this reason, it is subjected
 to new dimensions of research every day. The aggressiveness of the cancer is directly
 proportional to the histopathological grade at the time of diagnosis. This is true with
 reference to the clinical stage at the time of presentation, the probability to metastasize
 and potential to recur. The idea of steroids receptor expression by the tumour is not new,
 and to evaluate their status prior to the induction of hormone therapy is a must.

 The sex steroids, which are produced intratumorally, include estrogen, progesterone, and
 androgens. They act on their specific receptors present on the cell surface, within the
 cytoplasm and at the nuclear membrane. It is a measurement of these receptors that decide the
 potential of an individual to respond to different types of hormones like estrogen receptor
 blockers and aromatase inhibitors. Do the histological grade of tumour bears some relation
 with the status of these receptors and can investigators predict and rely just on the
 cellular behaviour of tumour for the purpose of prognosis is still under investigation. This
 study is designed to see the relationship between the histopathological grade of the tumour
 with the expression of sex steroid receptors. It will also try to evaluate whether these
 receptors bear some prognostic value or not.
Inclusion Criteria:

 -  All patients diagnosed with breast cancer irrespective of age, gender and clinical
 stage

 Exclusion Criteria:

 -  Any patient who lost to follow up