Age-related Clonal Haematopoiesis in an HIV Evaluation Cohort (ARCHIVE)
Age-related Clonal Haematopoiesis in an HIV Evaluation Cohort (ARCHIVE)
The ARCHIVE study is an observational longitudinal cohort study of people with and without
 HIV who are over the age of 55. The duration of the study is planned for 10 years, with study
 visits every 1-2 years. The objectives of the study are to evaluate genomic and other factors
 associated with aging, stratified by HIV status.
Inclusion Criteria:

 -  Men and women aged >55

 -  For participants without HIV: an HIV negative test within 12 months prior to
 enrolment. If no HIV-negative test result is available within 12 months prior to
 enrolment, then participants will be tested for HIV as part of standard of care, if
 indicated by the guidelines for HIV testing published by the Australasian Society for
 HIV, Viral Hepatitis and Sexual Health Medicine14. This study will not conduct HIV
 testing; therefore, any participants without HIV being considered for participation in
 the study will need to have had a standard of care HIV negative test within the past
 12 months. Some subjects at on-going risk for HIV are recommended to have periodic HIV
 testing and may be due for such testing as part of standard of care, at the time of
 enrolment into the study.

 -  Willing and able to provide written informed consent and willingness to participate in
 and comply with a longitudinal cohort study including 1) consent to providing blood
 samples for full blood count, inflammatory marker testing and genomics analysis 2)
 consent to linking their data to national and state-wide data registries (including
 consent to providing personally identifying information); and 3) consent to
 participate in future follow-up studies

 Exclusion Criteria:

 - Unwilling or unable to provide consent to participate