The Trans-cutaneous Effects on Physiological Tremor Entertainment During tACS
The Trans-cutaneous Effects on Physiological Tremor Entertainment During tACS
Transcranial alternating current stimulation (tACS) is a noninvasive neuromodulation method
 that works by passing alternating electric current between electrodes where at least one of
 them is attached to the head. This has been shown to have effects on the motor system,
 cognition and behavior. The exact mechanism by which tACS causes such effects is not fully
 understood. Some studies suggests a contribution from the stimulated peripheral nerves
 present in the scalp rather than direct brain effects. To test this hypothesis two arms will
 be done. First, 12 subjects (arm 1) will be stimulated using focused 4x1 montage with
 gel-filled cup-electrodes over the motor cortex and the effects will be compared between
 anesthetized and non-anesthetized scalp. The effects of anesthetizing the scalp will be
 tested on three different stimulation amplitudes off (0 mA), low (0.5 mA) and high (2.5 mA).
 Then, 10 subjects (arm 2) will be stimulated over the contralateral arm to exclude any direct
 brain stimulation effects and to test if peripheral nerve stimulation can entrain the tremor.
 Three outcome measurements will be measured during the experiments which are: tremor
 entrainment, sensation intensity and sensation threshold.
Inclusion Criteria:

 -  Above 18

 -  Signed informed consents

 Exclusion Criteria:

 -  Pregnancy

 -  History of Epilepsy

 -  Family history of Epilepsy