Efficacy, Safety, and Tolerability of Ancrod in Patients With Sudden Hearing Loss
Efficacy, Safety, and Tolerability of Ancrod in Patients With Sudden Hearing Loss
The purpose of this study is to determine whether ancrod is effective and safe in the
 treatment of sudden sensorineural hearing loss (SSHL).
Inclusion Criteria:

 -  Unilateral idiopathic sudden sensorineural hearing loss ≥30 dB

 -  Symmetric hearing prior to onset of SSHL

 -  Enrollment has to be accomplished within 7 days after SSHL onset

 Exclusion Criteria:

 -  Bilateral SSHL

 -  Incomplete recovery after previous SSHL

 -  Previously existing, known retrocochlear hearing loss

 -  Any history of any ear operation or local inflammatory disease in the past one year

 -  History of blunt or penetrating ear trauma, head trauma, barotrauma, or acoustic
 trauma immediately preceding SSHL

 -  History of Meniere's disease, autoimmune hearing loss, radiation-induced hearing loss,
 endolymphatic hydrops.

 -  Treatment with steroids for any reason within the preceding 30 days.

 -  Body weight > 140 kg