Target Volume in Noninvasive Positive Pressure Ventilation
Target Volume in Noninvasive Positive Pressure Ventilation
Patients with OHS are efficiently managed with long term home-based nocturnal noninvasive
 positive pressure ventilation (NIPPV). Several NIPPV devices offer the feature of
 automatically adjusting pressure support (and/or respiratory back-up rate) on the basis of a
 pre-determined "ideal tidal volume" or "ideal ventilation". However algorithms used to
 achieve these ideal targets are different among different commercialized devices and the
 relative efficacy from an algorithm compared to another remains unknown. The main objective
 is this study is to compare two commercialized NIPPV that have this option
RESMED Stellar-150 (IVAPS mode)versus PHILIPS-RESPIRONICS A30 (AVAPS-mode).
Inclusion Criteria:

 -  Patient with Obesity hypoventilation Syndrome (BMI≥ 30 kg/m2 and diurnal PaCO2 ≥
 45mmHg at diagnosis after exclusion of others causes of hypoventilation)

 -  18 to 75 years old

 -  In stable state but treated by nocturnal NIPPV for more than 3 months and adherent to
 NIPPV (above 4h/night).

 Exclusion Criteria:

 -  patient treated with additional long term Oxygen therapy

 -  Patient previously treated by AVAPS mode or IVAPS mode