The Relationship Between Arsenic Methylation Capability and Blood Metals in Children With Developmental Delays
The Relationship Between Arsenic Methylation Capability and Blood Metals in Children With Developmental Delays
The purpose of this study is to explore the relationship between arsenic methylation and
 blood metals in children with developmental delays and its correlation with health related
 quality of life.
The investigators recruited children with developmental delays and children with normal
 development from Shin-Kong Ho-Su Memorial Hospital as controls. Information obtained from the
 interview included socioeconomic and basic demographic characteristics as well as children
 function, health condition, and quality of life. On the other hand, blood and urine samples
 of the participants were collected for the analysis of arsenic methylation related enzymes
 using polymerase chain reaction and restriction fragment length polymorphism. 2 ml blood were
 digested for the determination of mercury, lead and arsenic. The relationship between arsenic
 methylation and blood metals in children with developmental delays and its correlation with
 health related quality of were analyzed.
Study group:

 Inclusion Criteria:

 -  children with developmental delays obtained written informed consent from parents

 Exclusion Criteria:

 -  parents refused for participation of their children to the intervention failed to
 obtain the written informed consent from parents

 Control group:

 Inclusion Criteria:

 -  children with normal development obtained written informed consent from parents

 Exclusion Criteria:

 -  parents refused for participation of their children to the intervention failed to
 obtain the written informed consent from parents