Percutaneous Nephrostomy Versus Stent In Sepsis Trial
Percutaneous Nephrostomy Versus Stent In Sepsis Trial
Randomized control trial to compare the efficacy and safety of percutaneous nephrostomy with
 retrograde ureteric stenting for emergency renal decompression in cases of obstruction and
 sepsis associated with ureteric calculi.
The obstructed kidney in the setting of urosepsis is a urological emergency. Stone
 manipulation in the setting of active, untreated infection with concomitant urinary tract
 obstruction can lead to life-threatening sepsis. Therefore, urgent decompression of the
 collecting system is warranted.

 There are two options for urgent decompression of an obstructed collecting system:

 1. Image-guided percutaneous nephrostomy tube placement

 2. Cystoscopic retrograde placement of a ureteric stent

 This strategy allows drainage of infected urine and penetration of antibiotics to the
 affected renal unit. Definitive stone manipulation should be delayed until the infection is
 cleared following an appropriate course of antimicrobial therapy.

 Both the European Association of Urology (EAU) and the American Urological Association (AUA)
 provide guidelines for management of an obstructed kidney. Both organisations provide
 evidence-based statements of the highest recommendation that urgent decompression of the
 kidney is mandated in the setting of sepsis. However, neither organisation recommend one
 decompression modality over the other. There is a lack of high quality up-to-date evidence to
 support a consensus view that one method of decompression is superior to the other.

 This study aims to determine the most effective method of renal decompression in cases of
 obstruction and sepsis associated with ureteric calculi.
Inclusion Criteria:

 -  Ureteric calculus with proximal hydronephrosis confirmed on CT KUB

 -  White cell count >12,000mm3 and/or temperature >38C

 Exclusion Criteria:

 -  Uncorrected coagulopathy

 -  Urethral or ureteric stricture disease

 -  Urinary diversion

 -  Pregnancy