Registry of Hypogonadism in Men
Registry of Hypogonadism in Men
The primary objective of the Registry of HYpogonadism in MEn (RHYME) is to establish and
 maintain a large, multi-national prospective registry of male patients who have been
 diagnosed with male hypogonadism (HG), also known as androgen deficiency or testosterone
 deficiency.
Inclusion Criteria:

 1. Male patients aged 18 years and older.

 2. Diagnosis of hypogonadism including Klinefelter's or late onset HG. Patients may have
 been diagnosed at any point in their lives. Documentation of the diagnosis of HG
 (including symptomatology and laboratory values including testosterone levels
 confirmed on two separate occasions) is required.

 3. Written informed consent.

 Exclusion Criteria:

 1. Any previous treatment with testosterone therapy.

 2. History of breast cancer, prostate cancer, or high-grade prostatic intraepithelial
 neoplasia.

 3. Prior radical prostatectomy.

 4. Life expectancy shorter than 24 months as judged by the Clinical Site investigator.

 5. Current major psychiatric disorders or drug or alcohol abuse, which will likely affect
 participation or compliance in the Registry, in the opinion of the Clinical Site
 Investigator.

 6. Gender dysphoria or sexual reassignment (e.g., transexualism).

 7. Patients actively enrolled in any interventional clinical trial.

 8. Planned relocation outside Clinical Site region within 24 months.