Docetaxel, Cisplatin, and Erlotinib Hydrochloride in Treating Patients With Stage I-III Non-small Cell Lung Cancer Following Surgery
Docetaxel, Cisplatin, and Erlotinib Hydrochloride in Treating Patients With Stage I-III Non-small Cell Lung Cancer Following Surgery
This phase I trial studies docetaxel, cisplatin, and erlotinib hydrochloride in treating
 patients with stage I-III non-small cell lung cancer following surgery. Drugs used in
 chemotherapy, such as docetaxel and cisplatin, work in different ways to stop the growth of
 tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them
 from spreading. Erlotinib hydrochloride may stop the growth of tumor cells by blocking some
 of the enzymes needed for cell growth. Giving docetaxel, cisplatin, and erlotinib
 hydrochloride together may kill more tumor cells.
PRIMARY OBJECTIVES:

 I. To evaluate the safety/toxicity of neoadjuvant chemotherapy with cisplatin and docetaxel
 followed by maintenance therapy with the epidermal growth factor receptor (EGFR) inhibitor
 erlotinib (erlotinib hydrochloride) in patients with stage I-III non-small cell lung cancer
 (NSCLC) undergoing definitive treatment with surgery and/or radiation.

 II. To estimate the agreement in baseline to post-treatment changes of EGFR expression (i.e.,
 EGFR modulation) between buccal smears and bronchial tissue.

 SECONDARY OBJECTIVES:

 I. To evaluate the disease free survival of this therapeutic combination. II. To assess
 overall quality of life. III. To evaluate predictive biomarkers in early-stage NSCLC.

 OUTLINE:

 Patients receive docetaxel intravenously (IV) over 1 hour followed by cisplatin IV over 30-60
 minutes on day 1. Treatment repeats every 21 days for 3 courses in the absence of disease
 progression or unacceptable toxicity. Beginning within 90 days following definitive surgical
 resection, patients receive erlotinib hydrochloride orally (PO) daily for up to 1 year.

 After completion of study treatment, patients are followed up every 3 months for 1 year and
 then every 6 months for 4 years.
Inclusion Criteria:

 -  Patients must have histologically or cytologically confirmed diagnosis of stage I, II
 or III non-small cell lung cancer; tissue blocks or slides will be requested

 -  Patients must have surgically resectable disease and may not be treated with prior
 chemotherapy or radiation

 -  Patients must be able to tolerate systemic chemotherapy prior to surgical resection

 -  No acute intercurrent illness or infection

 -  Eastern Cooperative Oncology Group (ECOG) performance status 0-1

 -  Leukocytes >= 3,000/uL

 -  Absolute neutrophil count (ANC) >= 1,500/uL

 -  Platelets >= 100,000/uL

 -  Hemoglobin >= 8g/dL

 -  Creatinine within normal institutional limits OR creatinine clearance >= 60
 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal

 -  Bilirubin within normal institutional limits

 -  Alkaline phosphatase (alk phos) =< 2.5 x upper limit of normal (ULN); if alk phos >
 2.5 x ULN but =< 5 x ULN, patient is eligible if AST or ALT =< ULN

 -  Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< 1.5 x ULN; if
 AST or ALT > 1.5 x ULN but =< 5 x ULN, patient is eligible if alk phos is =< ULN

 -  Prior to study enrollment, all women of child-bearing potential must have a negative
 pregnancy test; women of child-bearing potential and men must agree to use adequate
 contraception (hormonal or barrier method of birth control; abstinence) prior to study
 entry, for the duration of study participation, and for 2 months after the completion
 of therapy; should a woman become pregnant or suspect she is pregnant while
 participating in this study, she should inform her treating physician immediately

 -  Patients with a history of non-melanoma skin cancer, or other malignancies treated 5
 years or more prior to the current tumor, from which the patient has remained
 continually disease-free, are eligible

 -  Ability to understand and the willingness to sign a written informed consent document

 Exclusion Criteria:

 -  Patients who have had prior chemotherapy or radiotherapy for lung cancer

 -  Patients may not be receiving any other investigational agents within 30 days of trial
 entry, including anti-EGFR drugs

 -  Patient has signs or symptoms of acute infection requiring systemic therapy

 -  Patient exhibits confusion, disorientation, or has a history of major psychiatric
 illness that may impair patient's understanding of the informed consent

 -  Uncontrolled intercurrent illness including, but not limited to, ongoing or active
 infection, symptomatic congestive heart failure (New York Heart Association Functional
 Classification class II or worse), unstable angina pectoris, serious or clinically
 significant cardiac arrhythmia, or psychiatric illness/social situations that would
 limit compliance with study requirements

 -  Patients refusing to sign the informed consent

 -  Patients with pre-existing peripheral neuropathy National Cancer Institute (NCI)
 Common Toxicity Criteria (CTC) grade 2 or worse

 -  Patients must not be pregnant or breast-feeding and all (male and female) must use a
 contraceptive method deemed acceptable by the investigator while receiving active
 treatment in the study and for up to two months following completion of therapy

 -  Patients with a history of severe hypersensitivity reaction to Taxotere and or
 polysorbate 80 must be excluded