Induced Hypertension for Acute Ischemic Stroke
Induced Hypertension for Acute Ischemic Stroke
The ultimate goal of this multicenter, phase II study is to increase blood pressure until
 either a neurologic response is seen or a target mean arterial pressure of 30% above baseline
 is achieved. IV fluids, IV phenylephrine and/or IV norepinephrine are used to rapidly raise
 mean arterial pressure in a controlled manner as serial assessments of neurologic function
 are performed.
This is a multicenter, pilot clinical trial. The primary outcome variables will be the
 presence or absence of improvement in NIHSS during treatment with induced hypertension and
 the number of adverse events. The secondary outcome variables will be final infarct size on
 MRI at 1 month and Barthel Index and Modified Rankin Scale at 3 months.

 All patients fulfilling the inclusion and exclusion criteria and who are willing to
 participate will receive intervention to induce hypertension, including intravenous saline,
 phenylephrine (neosynephrine) or levophed, and possibly oral midodrine. Blood pressure will
 be increased to a maximum mean arterial pressure (MAP) that is 30% above the baseline MAP as
 measured in the emergency department. The acute phase of the study will last for 3-5 days
 (for responders) and all patients will be followed up at 1 and 3 months post stroke onset.
 All patients will undergo neurologic, cognitive, and physical examinations as well as serial
 MRI studies with diffusion and perfusion-weighted imaging.

 Primary hypotheses will be measured using the National Institutes of Health Stroke Scale
 (NIHSS) and MRI. Improvement following induced hypertension will be measured by comparing
 NIHSS performed at multiple time points throughout the study. The ability to predict
 diffusion-perfusion mismatch will be determined by comparing MRI #1 and MRI #2. NIHSS and MRI
 will also be compared to determine if NIHSS correlates with reperfusion area on MRI.

 The secondary hypothesis of improved long-term outcome will be measured using the Barthel
 Index, the modified Rankin Scale, and MRI/Flair at 1 and 3 months post stroke symptom onset.
Inclusion Criteria:

 -  Patients with acute ischemic stroke in whom treatment can be initiated within 12 hours
 of a clearly defined symptom onset. (If the patient awakens with a deficit, time of
 onset is considered the time the patient was last seen functioning normally.)

 -  Age older then 18 years of age.

 -  Measurable neurologic deficit other than isolated facial weakness, sensory loss or
 ataxia. NIHSS must be > 4 points.

 -  Head CT showing no evidence of intracranial hemorrhage or mass lesion which might
 increase the risk of bleeding.

 -  Absence of ischemic changes on EKG (i.e. > than 1mm ST segment elevation or depression
 in at least two contiguous leads, new T waves inversion in two leads).

 -  No contraindication to MRI studies, including allergy to gadolinium.

 Exclusion Criteria:

 -  History of unstable angina, any recent angina (defined as chest pain) in the past 3
 months, recent myocardial infarction (less then 3 months), any history of ventricular
 arrhythmia, presence of left ventricular bundle branch block on EKG.

 -  History of severe and symptomatic cardiac valvular disease.

 -  History of congestive heart failure, dilated cardiomyopathy, hypertrophic obstructive
 cardiomyopathy, or known ejection fraction < 25%.

 -  Systolic blood pressure greater > 200 mm Hg or MAP > 120 mm HG when patient is
 initially monitored.

 -  Serum creatinine greater then 2 mg/dl.

 -  History of symptomatic peripheral vascular disease or Raynaud's syndrome.

 -  Suspected seizure at the onset of stroke.

 -  Treatment with IV tPA or other thrombolytic agent.

 -  Massive stroke (> 2/3 MCA territory) or any amount of midline shift due to cerebral
 edema on head CT.

 -  Pregnancy

 -  Current use of MAO inhibitors, tricyclic antidepressant medications, or cyclopropane
 or halothane anesthetic agents.

 -  Coma.

 -  Allergies or known contraindications to the use of IV phenylephrine, IV
 norepinephrine, sodium metabisulfite, or oral midodrine.

 -  Hemorrhage on initial MRI or CT or other structural lesion that might raise the risk
 of intracranial bleeding.

 -  Thrombocytopenia (plt < 100 k), PTT > 100 sec, INR > 3.0 at time of treatment.

 -  Participation in other investigational trial within 30 days.

 -  Moderate to severe baseline disability (pre-stroke Rankin score of > 3), severe or
 terminal concurrent medical illness with expected survival of < 3 months, or other
 concurrent medical or psychiatric condition which may limit neurologic assessment or
 patient follow-up in the opinion of the investigator.

 -  Requirement for anticoagulation with IV heparin or warfarin in the first 48 hours
 after enrollment.

 -  Inability or unwillingness of subject or legal guardian/representative to give written
 informed consent.

 -  Toxicology screen positive for cocaine.

 -  Intubated at time of enrollment.

 -  Mesenteric or peripheral vascular thrombosis.

 -  Profound hypoxia or hypercarbia as defined as a PaO2 level less than 50 or a PaCO2
 level of greater than 60.

 -  Norepinephrine Exclusion Criteria- The patient will not receive Norepinephrine if the
 patient has any of the following: lack of sufficient vascular access (central line or
 peripheral line greater than 18 gauge is sufficient), hypersensitivity to
 norepinephrine products, severe hypertension as in 4.2.4 above, tachycardia defined as
 HR >100 for 10 minutes sustained, myocardial infarction, pulmonary edema, peripheral
 ischemia, or ventricular arrhythmias.