Postoperative Hypofractionated Intensity-modulated Radiation Therapy in Cervical Cancer
Postoperative Hypofractionated Intensity-modulated Radiation Therapy in Cervical Cancer
To investigate the acute toxicities, late toxicities, and treatment results when the early
 cervical cancer patients are treated by hypofractionated intensity-modulated radiotherapy
 (2.5 Gy X 16 fractions, once a day) after radical hysterectomy.
Inclusion Criteria:

 -  histologically confirmed cervical cancer

 -  radical hysterectomy and pelvic lymph node dissection was done

 -  histologically indicated adjuvant radiotherapy ( more than one as below)

 1. tumor size ≥4 cm

 2. positive lymphovascular invasion

 3. more than half stromal invasion depth

 -  ECOG performance status 0 or 1

 -  Bone marrow function: granulocyte ≥1.0 x 1000/µl, platelet ≥30 x 1000/µl, hemoglobin
 ≥10 g/dl

 Exclusion Criteria:

 -  positive pelvic lymph node metastasis

 -  positive distant metastasis (including retroperitoneal lymph node metastasis)

 -  positive tumor involvement on resection margin

 -  positive parametrial invasion

 -  previous history of pelvic radiotherapy

 -  more than 3 months after radical surgery for cervical cancer

 -  neoadjuvant chemotherapy was done

 -  previous history of other carcinoma except for thyroid cancer, skin cancer, in situ
 carcinoma on cervix