Combination Chemotherapy and Rituximab in Treating Patients With Newly Diagnosed AIDS-Related B-Cell Non-Hodgkin's Lymphoma
Combination Chemotherapy and Rituximab in Treating Patients With Newly Diagnosed AIDS-Related B-Cell Non-Hodgkin's Lymphoma
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer
 cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies,
 such as rituximab, can block cancer growth in different ways. Some find cancer cells and help
 kill them or carry cancer-killing substances to them. Others interfere with the ability of
 cancer cells to grow and spread. Giving combination chemotherapy together with rituximab may
 kill more cancer cells.

 PURPOSE: This phase II trial is studying how well giving combination chemotherapy together
 with rituximab works in treating patients with newly diagnosed AIDS-related B-cell
 non-Hodgkin's lymphoma.
OBJECTIVES:

 Primary

 -  Determine the complete response rate (complete response and complete response
 unconfirmed) in patients with newly diagnosed, AIDS-related B-cell non-Hodgkin's
 lymphoma treated with doxorubicin hydrochloride liposome, rituximab, cyclophosphamide,
 vincristine, and prednisone (DR-COP).

 -  Determine the duration of response (relapse-free survival) in patients treated with this
 regimen.

 -  Determine the median survival time of patients treated with this regimen.

 -  Determine rate of bacterial, fungal, and opportunistic infections in patients treated
 with this regimen.

 Secondary

 -  Determine, preliminarily, the relationship between MDR-1 expression in tumor tissue and
 response to therapy in patients treated with this regimen.

 -  Determine, preliminarily, any relationship between response and survival and BCL-2
 expression in tumor tissue in patients treated with this regimen.

 -  Determine any relationship between development of bacterial, fungal, and/or
 opportunistic infections and baseline CD4 lymphocyte count, HIV-1 RNA level, and
 quantitative immunoglobulin levels, or changes in quantitative immunoglobulin levels
 over time in patients treated with this regimen.

 -  Compare the results of positron emission tomography (PET) scanning with traditional CT
 scans in predicting response to therapy in these patients.

 -  Examine the relationship between chemotherapeutic drug levels and receipt of specific
 antiretroviral and/or anti-infective medications in these patients.

 -  Examine the mortality and the causes of death in patients treated with this regimen.

 -  Determine event-free survival at 1 year.

 OUTLINE: This is a nonrandomized, multicenter study.

 Patients receive doxorubicin hydrochloride liposome IV over 90 minutes, rituximab IV over 5-7
 hours, cyclophosphamide IV over 1 hour, and vincristine IV over 1-2 minutes on day 1 and oral
 prednisone on days 1-5. Patients also receive filgrastim (G-CSF), sargramostim (GM-CSF), or
 pegfilgrastim beginning on day 3 and continuing until blood counts recover. Treatment repeats
 every 21-28 days for up to 8 courses in the absence of disease progression or unacceptable
 toxicity.

 Patients undergo laboratory/biomarker studies at baseline and after every 2 courses of
 chemotherapy. Tissue is examined by immunohistochemistry for BCL-2, Ki67, and MDR-1, along
 with other markers.

 After completion of study treatment, patients are followed periodically for 3 years.

 PROJECTED ACCRUAL: A total of 44 patients will be accrued for this study.
DISEASE CHARACTERISTICS:

 -  Histologically or cytologically confirmed AIDS-related B-cell non-Hodgkin's lymphoma
 (NHL), including any of the following subtypes:

 -  Grade III follicular large cell lymphoma

 -  Diffuse large B-cell lymphoma

 -  Immunoblastic lymphoma

 -  Plasmablastic lymphoma

 -  Primary effusion lymphoma

 -  Previously untreated disease

 -  Any stage disease

 -  CD20 positive disease

 -  Must have documented HIV infection

 -  Documentation may be by serology (enzyme-linked immunosorbent assay, western
 blot), culture, or quantitative polymerase chain reaction or branched DNA assays

 -  Prior documentation of HIV seropositivity allowed

 -  Measurable or nonmeasurable disease

 -  Currently receiving effective highly active anti-retroviral therapy

 -  No primary CNS lymphoma, including parenchymal brain or spinal cord lymphoma

 -  No presence of leptomeningeal disease (positive cerebrospinal fluid for lymphoma) or
 presence of metastatic disease to brain, in terms of any mass lesion

 PATIENT CHARACTERISTICS:

 -  ECOG performance status (PS) 0-2 OR Karnofsky PS 50-100%

 -  Life expectancy ≥ 2 months

 -  Absolute granulocyte (neutrophil) count ≥ 1,000/mm³ (unless secondary to lymphomatous
 involvement of bone marrow)

 -  Platelet count ≥ 75,000/mm³ (unless secondary to lymphomatous involvement of bone
 marrow or due to HIV-related thrombocytopenia)

 -  Bilirubin ≤ 2.0 mg/dL (unless elevated secondary to lymphomatous involvement of liver
 or biliary system or due to other HIV medications [e.g., indinavir, tenofavir, or
 atazanavir])

 -  SGOT ≤ 5 times upper limit of normal

 -  Creatinine ≤ 2.0 mg/dL OR creatinine clearance ≥ 60 mL/min (unless secondary to renal
 involvement by lymphoma)

 -  LVEF normal by MUGA or echocardiogram

 -  Not pregnant or nursing

 -  Negative pregnancy test

 -  Fertile patients must use effective contraception during and for 6 months after
 completion of study treatment

 -  No other malignancy, except nonmelanoma skin cancer, carcinoma in situ of the cervix,
 or Kaposi's sarcoma that does not require systemic therapy

 -  No serious, ongoing, nonmalignant disease or infection that would preclude study
 compliance, in the opinion of the investigator

 -  No history of cutaneous or mucocutaneous reactions, or diseases in the past, due to
 any cause, severe enough to cause hospitalization or an inability to eat or drink for
 ≥ 2 days

 -  No acute, intercurrent infection that would preclude study treatment

 -  Patients with Mycobacterium avium are eligible

 -  No cardiovascular problems, including any of the following:

 -  Myocardial infarction within the past 6 months

 -  New York Heart Association class II-IV heart failure

 -  Uncontrolled angina

 -  Severe uncontrolled ventricular arrhythmias

 -  Clinically significant pericardial disease

 -  ECG evidence of acute ischemic or active conduction system abnormalities.

 -  No shortness of breath at rest

 -  Arterial PO_2 ≥ 70 or pulse oximeter-derived O_2 saturation ≥ 94% on room air (unless
 due to lymphomatous involvement of the lungs)

 -  Able to comply with study and provide adequate informed consent

 PRIOR CONCURRENT THERAPY:

 -  See Disease Characteristics

 -  At least 4 weeks since prior major surgery (except diagnostic surgery)

 -  At least 12 months since prior rituximab unless it was only given for indications
 other than the treatment of aggressive lymphoma

 -  No prior cytotoxic chemotherapy or radiotherapy for this lymphoma

 -  Concurrent radiotherapy, with or without steroids, for emergency conditions
 secondary to lymphoma (i.e., CNS tumor or cord compression) allowed

 -  No zidovudine or zidovudine-containing regimen (including Combivir® or Trizivir®)
 during and for 2 months after completion of chemotherapy

 -  Concurrent erythropoietin or filgrastim (G-CSF) allowed

 -  Growth factor therapy must be discontinued ≥ 24 hours prior to study entry