A Study to Determine the Efficacy of Topically Applied MTC896 Gel in Subjects With Acne Vulgaris
A Study to Determine the Efficacy of Topically Applied MTC896 Gel in Subjects With Acne Vulgaris
This study is designed to investigate the efficacy, safety and tolerability of MTC896 Gel in
 subjects with acne. In this study, MTC896 Gel will be applied at 3 concentrations, twice
 daily (bid) for 12 weeks and compared against a vehicle control.
Inclusion Criteria:

 1. Is a male or nonpregnant, non-lactating, non-breastfeeding female, 16 to 65 years of
 age, inclusive, at the time of screening;

 2. Has provided written informed consent/assent (which includes consent for photographs,
 if applicable, to be taken at Baseline and end-of-treatment/end-of-study [EOT/EOS]
 visits);

 3. Has been diagnosed with mild-to-severe acne vulgaris defined as:

 -  At least 20 inflammatory lesions,

 -  At least 20 noninflammatory lesions,

 -  ≤ 2 nodular lesions, and

 -  Investigator Global Assessment of 2 or greater;

 4. Is willing to comply with the requirements of the protocol;

 5. If female and of child-bearing potential or premenarcheal, has a negative urine
 pregnancy test at Screening and Baseline / Day 1 and is willing to use effective
 contraception during the study and for 30 days after the last study medication
 application. Females are considered to be of childbearing potential unless surgically
 sterilized (hysterectomy, bilateral oophorectomy, tubal ligation), diagnosed as
 infertile, or are postmenopausal for at least 1 year; (Acceptable methods of birth
 control are defined as: abstinence, oral contraceptives, contraceptive
 patches/implants, Depo-Provera®, double barrier methods (e.g. condom and spermicide)
 or an intrauterine device (IUD). Birth control method must have been stable/unchanged
 for 12 weeks prior to Baseline and must remain unchanged during study participation);

 6. If male, has been vasectomized or agrees to use an accepted method of birth control
 with female partner during study participation and for 30 days after the last study
 medication application;

 7. Is in good health and free from any disease which, in the opinion of the Investigator,
 would put the subject at risk if participating in the study;

 8. Is free of any systemic or dermatologic disorder, which, in the opinion of the
 Investigator, will interfere with the study results or increase the risk of adverse
 events;

 9. Is willing to abstain from using any facial treatment products on the face during the
 study (continued use of make-up is permitted but may not be changed within 2 weeks
 prior to the study period or during the entire study period);

 10. Is willing to avoid sun exposure and to protect the face with a hat/visor; sunscreen
 use is recommended/allowed when sun exposure cannot be avoided;

 11. If male, must agree to shave the treatment area and must agree not to alter his
 routine shaving regimen for the duration of the study;

 12. Is willing to refrain from using any treatments, other than the study medication,
 including antibiotics, for acne present on the face. Topical acne treatments that do
 not have significant or measurable systemic absorption (e.g. benzoyl peroxide,
 salicylic acid) are allowed for treatment of acne of the back, shoulders, and chest
 only.

 Exclusion Criteria:

 1. People who would otherwise qualify for the study, but are living in the same household
 as a study subject, are not allowed to participate in the study;

 2. Pregnant or lactating or plan to become pregnant within 1 month (30 days) of study
 completion;

 3. Known allergy/sensitivity to any of the study medication components;

 4. Any skin condition which may interfere with the evaluation of safety or of acne
 vulgaris (e.g. rosacea, seborrheic dermatitis, perioral dermatitis,
 corticosteroid-induced acne or folliculitis);

 5. Excessive facial hair that would interfere with diagnosis or assessment of acne
 vulgaris;

 6. Excessive sun exposure, in the opinion of the Investigator, or use of tanning booths;

 7. Active cystic acne or acne conglobata, acne fulminans, and secondary acne;

 8. Screening clinical chemistry or hematology laboratory value that is considered
 clinically significant, in the opinion of the Investigator;

 9. Participation in an investigational drug study within 30 days prior to Screening;

 10. Is a poor medical risk because of other systemic diseases or active uncontrolled
 infections, in the opinion of the Investigator;

 11. Any other condition which, in the judgment of the Investigator, would put the subject
 at unacceptable risk for participation in the study;

 12. Within 9 months (270 days) prior to Baseline and throughout the study:

 - Oral retinoid use (e.g. isotretinoin);

 13. Within 6 months (180 days) prior to Baseline and throughout the study:

 - Treatment with Vitamin A supplements greater than 10,000 units/day;

 14. Within 3 months (90 days) prior to Baseline and throughout the study:

 -  Use of androgen receptor blockers (such as spironolactone or flutamide);

 -  Initiation of treatment with hormonal therapy or dose change to hormonal therapy;

 -  Dose and frequency of use of any hormonal therapy started more than 3 months (90
 days) prior to Baseline must remain unchanged throughout the study;

 -  Hormonal therapies include, but are not limited to, testosterone, anabolic
 steroids, birth control pills;

 15. Within 8 weeks (56 days) prior to Baseline and throughout the study:

 - Facial procedures (chemical or laser peel, microdermabrasion, etc.);

 16. Within 4 weeks (28 days) prior to Baseline and throughout the study:

 -  Treatment with systemic corticosteroids (including intranasal and inhaled
 corticosteroids);

 -  Treatment with systemic antibiotics or systemic anti-acne drugs or systemic
 anti-inflammatory drugs; Note: Non-steroidal anti-inflammatory drugs (NSAIDs) and
 aspirin use on an as-needed basis and if not used consecutively for >14 days
 prior to Baseline is acceptable and does not require washout. Low dose (81 mg)
 aspirin taken daily is acceptable.

 -  Prescription topical retinoid use on the face (e.g. tretinoin, tazarotene,
 adapalene);

 -  Antifungals, antiretrovirals and antibiotics included in the CYP 3A4 and CYP 3A5;

 17. Within 2 weeks (14 days) prior to Baseline and throughout the study:

 -  Treatment with topical prescription antibiotics (e.g. dapsone, clindamycin,
 erythromycin, or sulfacetamide);

 -  Treatment with over-the-counter (OTC) topical medications for the treatment of
 acne vulgaris including benzoyl peroxide, topical anti-inflammatory medications,
 corticosteroids, α-hydroxy/glycolic acid on the face;

 18. Within 1 day prior to Baseline and throughout the study:

 -  Grapefruit juice which is included in the CYP 3A4 and CYP 3A5.