Urine and Serum Concentrations of Pregnancy-Associated Compounds During Gestation
Urine and Serum Concentrations of Pregnancy-Associated Compounds During Gestation
Investigators will collect serum and urine specimens from pregnant patients along the full
 pregnancy continuum, assay each specimen for selected placental proteins, and examine the
 relationships between concentrations of the proteins and gestational age as determined by
 ultrasound.
Investigators will collect serum and urine specimens from pregnant patients along with
 ultrasound results and information about factors that may affect the concentrations of
 proteins or the estimation of gestational age. Investigators will obtain data across the full
 pregnancy continuum but we will over sample patients within five gestational weeks before and
 after the 10 week mark.

 Investigators will assay each specimen for selected placental proteins (Human placental
 lactogen (HPL), Schwangerschaftsprotein 1 (SP1), Pregnancy-associated plasma protein A
 (PAPP-A), A Disintegrin and Metalloproteinase 12 (ADAM12), and Human chorionic gonadotropin
 (HGC)) and any other proteins of interest identified prior to running assays and will examine
 the relationships between concentrations of the proteins and gestational age as determined by
 ultrasound.

 The goal is to identify at least one compound and a concentration threshold for that compound
 that can be used for differentiating pregnancies of less than 10 weeks in duration from later
 pregnancies.
Inclusion Criteria:

 -  Has an intrauterine pregnancy confirmed by ultrasound

 -  Not known to have pregnancy-induced hypertension (preeclampsia) or diabetes

 -  Not known to have a nonviable pregnancy, a multiple pregnancy, a pregnancy with a
 chromosomal or fetal abnormality, or a pregnancy with growth restriction

 -  Not currently taking anticoagulants

 -  Not currently having clinically significant vaginal bleeding, unusual pelvic pain, or
 other symptom suggestive of a pregnancy complication

 -  No use of assisted reproductive technology to conceive the current pregnancy

 -  Not previously enrolled in this study

 Exclusion Criteria:

 -  Does not meet inclusion criteria