A Study of the Effect of Linaclotide on Abdominal Girth in Participants With IBS-C
A Study of the Effect of Linaclotide on Abdominal Girth in Participants With IBS-C
The objective of this trial is to determine the effect of linaclotide on abdominal girth in
 irritable bowel syndrome with constipation (IBS-C) participants with the baseline symptoms of
 abdominal bloating and an increased abdominal girth.
Inclusion Criteria:

 • Patient meets protocol criteria for diagnosis of IBS-C, abdominal pain, abdominal
 bloating and abdominal girth

 Exclusion Criteria:

 -  Patient has history of loose or watery stools

 -  Patient has both clinically significant findings and unexplained clinically
 significant alarm symptoms

 -  Patient has symptoms of or been diagnosed with a medical condition that may contribute
 to abdominal pain

 -  Patient has any protocol-excluded or clinically significant medical or surgical
 history that could confound the study assessments