Follow-up Visit of High Risk Infants
Follow-up Visit of High Risk Infants
The NICHD Neonatal Research Network's Follow-Up study is a multi-center cohort in which
 surviving extremely low birth-weight infants born in participating network centers receive
 neurodevelopmental, neurosensory and functional assessments at 22-26 months corrected age
 (Infants born prior to July 1, 2012 were seen at 18-22 months corrected age). Data regarding
 pregnancy and neonatal outcome are collected prospectively. The goal is to identify potential
 maternal and neonatal risk factors that may affect infant neurodevelopment.
The NICHD Neonatal Research Network's Follow-Up study is a multi-center cohort study in which
 surviving extremely low birth-weight infants undergo neurodevelopmental, neurosensory and
 functional assessments at 22-26 months corrected age (Infants born prior to July 1, 2012 were
 seen at 18-22 month corrected age). The goal of the study is to identify potential maternal
 and neonatal risk factors that may affect infant neurodevelopment, including:

 -  Evaluating development of motor skills, cognitive skills, language and behavior

 -  Determining mortality and the prevalence of specific medical conditions

 -  Assessing the relationship between growth and neurodevelopmental outcome

 -  Assessing the relationship between the socioeconomic status and developmental outcome

 -  Assessing the use of special support services and early intervention programs by this
 population

 -  Evaluating the need for follow-up at school age.

 The scheduled evaluations collect: demographic information; socioeconomic status; medical
 history; medications; medical equipment required; growth data; a detailed neurologic
 examination; Bayley Scales of Infant Development (mental, motor, infant behavior); Child
 Behavior Checklist.

 A sub-study will assess a reference group comprised of a limited number of healthy term
 infants born in Network centers to meet the following three aims: 1) to avoid potential
 ascertainment biases due to examiner expectations when only extremely preterm or other
 high-risk infants are assessed 2) in the absence of well-developed norms for the Bayley
 Scales, to define thresholds for impairment based on data for a representative sample of
 healthy children born at term in our centers and concurrently assessed by the same examiners
 as for our high-risk infants; and 3) to help identify and address when "drift" occurs over
 time in conducting and scoring Bayley assessments.
-  Infants inborn at NRN centers

 -  <27 weeks gestational age

 -  Infants enrolled in one or more additional NICHD NRN Follow-up studies. For infants
 that do not meet the inclusion criteria above, inclusion and exclusion criteria are
 determined by the criteria for the additional trial(s). In these cases, infants that
 are larger than 1,000 grams and/or older than 27 weeks may be included in the FU
 Study.

 Note: These inclusion criteria were changed as of 1/1/2008. Prior to this date, infants
 with birth weights between 401 and 1500 grams who were admitted to NRN NICUs within 14 days
 of birth were included in the database.