Effect of Carotid Artery Stent on Evoked Cerebral Blood Oxygenation and Neurocognitive Functioning
Effect of Carotid Artery Stent on Evoked Cerebral Blood Oxygenation and Neurocognitive Functioning
Cerebral hemodynamic compromise from internal carotid artery stenosis may be a cause of
 vascular cognitive impairment that is amenable to treatment by revascularization. The effect
 of carotid artery stent on evoked cerebral blood oxygenation and neurocognitive functioning
 will be evaluated by functional near-infrared spectroscopy. Carotid artery stent could
 benefit cerebral blood oxygenation after stent and improving neurocognitive functioning after
 6 months.
Patients with high grade internal carotid artery stenosis intended to carotid artery stent
 are brought to this study. Global cognitive function and evoked cerebral blood oxygenation
 are evaluated before and after stent, followed up at 6 months later. Mini-Mental State
 Examination(MMSE) and Montreal Cognitive Assessment (MoCA) are used for the global cognitive
 test. Evoked cerebral blood oxygenation is evaluated using functional near-infrared
 spectroscopy(fNIRS) through performing mental task( N-back task, Go/no go task, and verbal
 fluency task ). All the patients from different centers are conducted the test at the only
 main center by one doctor. The parameter of fNIRS and score of cognitive test of each patient
 are compared before and after stent.
Inclusion Criteria:

 1. 35-80 years old

 2. Severe carotid stenosis (MRA or CTA confirmed stenosis rate of 70% - 99%, NASCET
 standard)

 3. Asymptomatic or mild stroke (NIHSS ≤ 3) or TIA

 4. Agree to participate in the clinical trial and sign the informed consent

 Exclusion Criteria:

 1. Severe stenosis or occlusion of vertebrobasilar artery and other intracranial arteries
 (70% - 99%)

 2. Left ventricular ejection fraction < 50% or heart failure

 3. Other types of dementia have been diagnosed

 4. Severe depression, mental illness, epilepsy

 5. Not cooperating with cognitive task evaluation