Effect of the Plantago Ovata Husk on the Lipid Profile of Patients With Hypercholesterolemia
Effect of the Plantago Ovata Husk on the Lipid Profile of Patients With Hypercholesterolemia
The hypothesis of this study is that soluble fibre may contribute to a reduction of the low
 density lipoprotein cholesterol (LDL-c), and the combined effect with a statin may achieve an
 optimisation of the cholesterol-lowering effects in adults with several cardiovascular risk
 factors.
It has been demonstrated that high concentrations of cholesterol and low density lipoprotein
 cholesterol (LDL, high risk cholesterol) are the major risk factors for heart disease,
 myocardial infarction and angina pectoris. Moreover, these conditions represent the major
 cause of death in the Western world.

 Of the measures established to reduce blood cholesterol levels, the introduction of
 consumption of dietary fibre is a novelty. The term dietary fibre defines a variety of
 substances that are found in plants and are resistant to digestion by human gastrointestinal
 enzymes.

 The studies performed up until now to determine the effects of fibre on blood lipids have
 demonstrated that consumption of soluble fibre can reduce cholesterol.
Inclusion Criteria:

 -  Levels of LDL-c between >130 mg/dl and <189 mg/dl

 -  Presence at least 1 of the cardiovascular risk factor defined as:

 -  age above 45 years in men and 55 years in women

 -  smoker

 -  high blood pressure

 -  HDL-c < 40 mg/dl in men and <46 mg/dl in women

 -  family background of early heart disease

 -  Patients who have given informed consent

 -  Patients who will be capable of following diet guidelines

 Exclusion Criteria:

 -  Triglycerides >350 mg/dl

 -  History of cardiovascular disease

 -  treatment with statins prior to the beginning of the trial and who have not
 dropped out at least 2 months before the beginning of the study

 -  Diabetes mellitus