PROADAPT-ovary/EWOC-2
PROADAPT-ovary/EWOC-2
PROADAPT is a standardized geriatric intervention that is currently being co-constructed
 during an exploratory phase on a multi-professional and multi-disciplinary basis after a
 systematic analysis of published data (Figure).

 It consists in: 1) before surgery: a prehabilitation of the patients including a nutritional,
 physical and educational preparation; 2) during the hospitalization for surgery: an
 optimisation of their treatments through a pharmaceutical conciliation, educational
 interventions, standardization of surgical procedures and enhanced rehabilitation after
 surgery; 3) bridging and post-discharge interventions for hospital-to-home transition.

 This intervention is based on a logic change model, constructed with literature data and
 validated by an expert group through a DELPHI method : the rehabilitation model.

 This intervention was designed to be implemented pragmatically in the centers according local
 habits and is currently being evaluated in several distinct hospital contexts under the name
 of "PROADAPT pilot study" in different tumor contexts thanks to a grant from the Regional
 Health Agency of Rhône-Alpes Auvergne region.

 PROADAPT intervention is planned to be evaluated in 4 tumor models inducing complex
 medico-surgical procedures considered at high risk of geriatric deconditioning. They have the
 same primary objectives in order to be evaluated into a meta-analysis. Results will be used
 to test the validity of the rehabilitation model. Therefore, it is a study reaching the goal
 of the population health intervention research.

 The purpose of the PROADAPT-ovary/EWOC-2 study is to evaluate the impact of PROADAPT on
 patient's post-surgical outcomes in patients ≥ 70 years old with an advanced ovarian cancer
 (AOC).
With the conjunction of increased life expectancy and the increasing incidence of cancer with
 aging, older patient represent an increasing proportion of cancer patients. Increasing age is
 also associated with increased risk of co-morbidities as well as a decline of functional
 reserve of multiple organ systems, eventually leading in the context of the disease-and/or
 the treatment-related stress to functional deconditioning or organ failure.

 Surgery or complex medico-surgical procedures can be considered as one proof-of principle of
 such risks, since major cancer surgery the older population is at higher risk of
 morbi-mortality and unplanned hospitalization for geriatric events1.

 In order to reduce complications after surgery, prehabilitation has often been considered,
 and 71% of the surgeons would accept a 4 weeks delay before surgery to improve patients'
 outcomes if shown to be beneficial2. However, the actual level of evidence depends on the
 interventions: high for pre-operative nutrition3, but low for physical exercise, due to
 heterogeneous programs with often bad adherence4. In addition, geriatric validated
 interventions, in order to prevent iatrogenic event, may be added in a multi-interventional
 model of intervention.
Inclusion Criteria:

 -  Woman ≥70 year old OR Woman ≥60 years with significant comorbid condition (modified
 Charlson index≥3) or disability (ADL score<6/6);

 -  Histologically or cytologically proven FIGO (International Federation of Gynecology
 and Obstetrics) stage III to IV epithelial ovarian cancer or peritoneal primary or
 fallopian tube. A cytological proof is accepted if associated with a ratio of
 CA125/CEA >25 and a radiological pelvic mass.

 -  Patient oriented towards a complex medical procedure defined by pelvic surgery
 preceded or not by antineoplastic treatment (neoadjuvant chemotherapy).

 -  Therapeutic decision validated in a multidisciplinary consultation meeting

 -  Life expectancy > 3 months.

 -  Written informed consent obtained.

 -  Covered by a Health System where applicable.

 Exclusion Criteria:

 -  Any other progressive malignant tumor interfering with the patient's prognosis.

 -  Patient whose validated therapeutic management does not include cytoreductive surgery.

 -  Patient unable to be regularly followed up for any reason (geographic, family, social,
 psychological).

 -  Patient unable to understand the questionnaires.

 -  Patient unable to follow and adhere to test procedures for geographic, social or
 psychological reasons.

 -  Patient placed under guardianship or curatorship.

 -  Patient deprived of liberty.

 -  Concurrent participation in another interventional drug trial.

 -  Patient already included in this study