Identifying Risk Factors for Developing AKI in Sepsis
Identifying Risk Factors for Developing AKI in Sepsis
A study to evaluate the prevalence of Acute Kidney Injury (AKI) in patients with Diabetic
 Ketoacidosis (DKA) and sepsis using data collected prospectively to a patient registry. The
 primary objective is to compare the prevalence of AKI in sepsis and DKA in different age
 groups in children and investigate the difference in the prevalence of hyperchloremia in the
 two groups.Secondary objectives are Compare the prevalence of AKI in sepsis and DKA in
 different age groups in children and investigate the difference in the prevalence of
 hyperchloremia in the two groups.
It is a descriptive study to report the prevalence ofAcute Kidney Injury ( AKI) in the two
 cohorts of sepsis and Diabetic Ketoacidosis ( DKA). In addition we aim to evaluate the
 relation with hyperchloremia. In both groups, attempts will be made to evaluate the
 association of risk factors such as severity of dehydration/shock and hyperchloremia with AKI
 in the two groups.

 Data will be analysed using SPSS software. Categorical variables will be analysed using
 Chi-square test and if appropriate, multiple logistic regression analysis. Continuous
 variable will be analysed with Student's T test and if possible, by linear regression
 modelling. The differences between the two groups may analysed using Analysis of Variance
 (ANOVA).

 The study will collect anonymous data from 2015 to 2020 from the Paediatric Intensive Care
 Audit Network (PICANet) database for a tertiary PICU servicing the pediatric population of
 Wales.This data is submitted prospectively for audit of clinical outcomes of children
 admitted for paediatric intensive care in the United Kingdom. The study was reviewed by the
 Institutional Research and Development department and was given exemption for ethics
 committee review as it does not involve direct patient contact and the data is anonymous.
 Approval was obtained from the relevant database manager, institutional information
 governance department as well as the Health Care Research Wales.
Inclusion Criteria

 -  Children under 16 years and admitted to PCCU or wards in the past 5 years

 -  Diagnosis of DKA or Sepsis/severe bacterial infection/septic shock

 DKA - defined as per the British Society for Paediatric Endocrinology and Diabetes (BSPED)
 guidance. Sepsis is defined based on the International Pediatric Sepsis Consensus
 Conference guidance (2005)

 8.3. Exclusion Criteria

 -  Any patients identified as above but not able to obtain case notes for any reason.

 -  Patients with pre-existing kidney conditions

 -  Patients with inborn errors of metabolism