A Diagnostic Experimental Study of Characteristic Sound Waves in Radial Artery of Early Pregnant Women
A Diagnostic Experimental Study of Characteristic Sound Waves in Radial Artery of Early Pregnant Women
Pulse diagnosis is an important method to judge the health status of patients in the process
 of diagnosis and treatment of traditional Chinese medicine. at present, the commonly used
 site of pulse diagnosis is the radial artery, which is divided into "cun", "guan" and "chi".
 Whether the diagnosis of pregnancy can be diagnosed by pulse diagnosis has been perplexing
 clinicians. In long-term clinical practice, it is found that slippery vein (slippery pulse)
 often occurs in the radial artery of pregnant women. Before the 13th week of pregnancy, it
 was called early pregnancy. During pregnancy, chorionic gonadotropin gradually increased,
 progesterone increased, humoral metabolism changed, blood volume increased, hemodilution and
 cardiac output increased. Other studies have shown that due to the effect of estrogen, the
 number of active levels of renin in plasma increased several times, and increased with the
 increase of pregnancy. This series of changes in pregnant women may be reflected in the
 pulse. During the clinical pulse examination, our team found that some pregnant women had no
 abnormality in pre-pregnancy examination such as B-ultrasound, and abnormal "astringent pulse
 (hesitant pulse)" in the ulna could be felt during pulse examination. Through follow-up, it
 was found that this kind of pregnant women may have miscarriage or stillbirth.

 Our team found that there are low-frequency sound waves in the radial artery, which carry the
 physiological and pathological information of the organs in the body, and developed a
 "acoustic pulse detection system". Previous projects have explored the abnormal sound waves
 of radial artery in patients with sequelae of cerebral infarction, stable coronary heart
 disease, chronic gastritis, neck-shoulder syndrome, liver cirrhosis and other diseases and
 achieved certain results.

 Therefore, in this study, the "acoustic pulse detection system" will be used to collect the
 sound waves in the radial artery of 76 healthy early pregnant women and 76 healthy
 non-pregnant women, and carry on the frequency spectrum analysis and wavelet analysis to
 extract the pulse features. and carry on the diagnostic test, calculate the sensitivity and
 specificity of the "acoustic pulse diagnosis detection system" in the diagnosis of pregnancy.
 This study will verify the efficacy of pulse diagnosis of traditional Chinese medicine in the
 diagnosis of pregnancy and lay a foundation for the diagnosis of abnormal pregnancy.

 It is assumed that there is a characteristic sound wave in the radial artery of early
 pregnant women, which has a specific distribution, plane and point, which is different from
 that of healthy non-pregnant women.
Inclusion Criteria:

 Test group:

 1. Pregnant women who have been diagnosed as early pregnancy by laboratory and ultrasound

 2. First-born singleton pregnancy, from 6 weeks to 13 weeks

 3. There were no pregnancy complications, the vital signs were stable, and the results of
 biochemical tests were normal.

 4. Patients with informed consent to accept this pulse collection

 Control group:

 1. The inclusion of relatively healthy people is those with negative diagnostic criteria
 for early pregnancy pregnant women;

 2. Patients with informed consent to accept this pulse collection;

 3. The vital signs were stable, the results of biochemical tests were normal, and there
 were no major diseases of brain, liver and kidney.

 Exclusion Criteria:

 Test group:

 1. Pregnant women with ovarian, fallopian tube, uterine diseases, hypertension and
 diabetes during pregnancy;

 2. Definitely diagnose patients with respiratory, cardiovascular, cerebrovascular, liver
 and kidney, blood, endocrine and other system diseases and severe infectious diseases;

 3. Those who have had a cesarean section; history of miscarriage

 4. Those who have a serious illness and sit for less than 10 minutes in a quiet state;

 5. Patients with mental illness, depression, and cognitive impairment;

 6. Fanguan pulse, oblique flying pulse, etc. who are not easy to collect pulse;

 7. Those who have incomplete information due to subjective or objective reasons that
 affect the result judgment;

 8. Patients with Parkinson's or other limb tremors;

 9. A person who has not signed an informed consent form.

 Control group:

 1. Those who have had a history of miscarriage or ectopic pregnancy;

 2. Patients with severe infectious diseases;

 3. Fanguan pulse, oblique flying pulse, etc. who are not easy to collect pulse;

 4. The incomplete information affects the judgment of the result due to subjective or
 objective reasons;

 5. Patients with Parkinson's or other limb tremors;

 6. Women in the ovulation period.