Study of Inflammatory Role of Epstein-Barr Virus (EBV) in Atrophic and Erosive Forms of Oral Lichen Planus
Study of Inflammatory Role of Epstein-Barr Virus (EBV) in Atrophic and Erosive Forms of Oral Lichen Planus
Oral lichen planus (OLP) is a chronic inflammatory and relapsing. The average prevalence is 1
 to 4%. The clinics forms are many and symptoms are varied. The erosive form, painful and
 debilitating is characterized by erosive areas, ulcerated on an erythematous base with or
 without a keratinocyte lichenien network.

 The literature data moving towards an autoimmune origin, but the pathophysiological
 mechanisms of OLP remain unknown.

 This project represents the first part of a comprehensive project to examine the oral
 pathogenesis of different viruses (Herpes and papillomavirus HPV) and centered on
 Epstein-Barr Virus (EBV).
Inclusion Criteria:

 -  Patient ≥ 18 years

 -  Clinical and/or histological diagnosis of erosive or atrophic OLP

 -  No signs of severe dysplasia at the sampling

 Exclusion Criteria:

 o immunosuppressive or anti-inflammatory therapies at the inclusion