Bupropion For Reducing High-Risk Behaviors in Depressed Men Who Have Sex With Men (MSM)
Bupropion For Reducing High-Risk Behaviors in Depressed Men Who Have Sex With Men (MSM)
The primary purpose of this study was to test the whether high-risk, HIV-seronegative persons
 with mild-to-moderate depression would be more likely to adopt protective behavior change
 when provided with pharmacotherapy for their depression than when treated with placebo.
 High-risk behaviors include using illegal drugs and participating in unprotected sexual
 intercourse. The specific pharmacotherapy used in this study was the anti-depressant,
 bupropion. The subject population consisted of HIV negative men who have sex with men (MSM)
 with mild-to-moderate depression.
Depression in men is often masked by high-risk behaviors such as alcohol and drug abuse.
 Common symptoms among depressed men include feelings of hopelessness and helplessness,
 irritability, and anger. MSM are among those at highest for HIV acquisition due to high-risk
 behaviors, including unprotected sexual intercourse and drug abuse. Bupropion is an
 antidepressant medication commonly used to treat depression. The purpose of this study thus
 was whether bupropion could help MSM with mild-to-moderate depression reduce their high-risk
 behaviors.

 Participants in this trial were randomly assigned to receive either bupropion or placebo for
 6 months. Study visits lasting approximately 2 hours each occurred at Day 0, and at Months 4,
 6, and 9; included in these visits were physical examination, testing for HIV and sexually
 transmitted disease (STD), depression screening, and an interview-administered questionnaire
 inquiring into sexual activity and drug use. Shorter study visits, lasting 15 - 30 minutes
 each occurred at Day 15, and Months 1, 2, 4, 5, and 7, and included depression screening and
 physical exam.
Inclusion Criteria:

 -  Available for at least 9 months, or the duration of the study

 -  Willing to complete HIV testing and counseling

 -  History of HIV testing and counseling

 -  At high risk of HIV infection, indicated by more than one male sexual partner in the 3
 months prior to study entry

 -  Meets criteria for either (a) major depression or dysthymia within a mild-to-moderate
 level according to standard criteria DSM-IV, or (b) minor depression as defined by one
 or more of the following symptoms at any time and for any duration during the past 12
 months: significant weight loss or gain, or significant decrease or increase in
 appetite; poor sleep pattern; noticeable irritability or slowness; fatigue or lack of
 energy; inappropriate feelings of worthlessness or guilt; inability to concentrate;
 indecisiveness; and recurrent thoughts of death or suicide.

 Exclusion Criteria:

 -  HIV infected

 -  Sexual intercourse in the 3 months prior to study entry with only one partner, and in
 a monogamous relationship

 -  Currently enrolled in another study involving repeated HIV testing and counseling

 -  Receiving treatment for depression with antidepressant medication for any length of
 time within the year prior to study entry

 -  Currently in psychotherapy, psychoanalysis, or any other form of talk therapy for any
 reason

 -  Severe depression or at suicidal risk

 -  No evidence or prior history of depression

 -  Homicidal or other similar problem that, in the opinion of the investigator, may
 endanger study staff and participants

 -  Currently taking monoamine oxidase inhibitors (MAOIs). Participants may be allowed to
 enroll 14 days after discontinuing use of a MAOI.

 -  History of seizures

 -  History or current symptoms of bipolar disorder