Examining Effects of Tysabri on Cognitive Fatigue Using fMRI
Examining Effects of Tysabri on Cognitive Fatigue Using fMRI
The purpose of this research study is to investigate the effectiveness of Tysabri on
 cognitive fatigue in persons with Relapsing-Remitting Multiple Sclerosis (RRMS). Cognitive
 fatigue is the kind of fatigue that occurs after intense mental concentration as after a
 session of problem solving.
The researchers aim is to investigate the effects of Tysabri on cognitive fatigue and on
 specific brain areas that have been shown to underlie cognitive fatigue in individuals with
 RRMS. The researchers will investigate the effects on the cognitive fatigue that develops
 during the performance of a demanding task and also on how cognitive fatigue changes as a
 function of duration of treatment.
Inclusion Criteria:

 -  Age between 18-64

 -  Diagnosed with Relapsing-Remitting Multiple Sclerosis or a healthy volunteer

 -  If diagnosed with MS: has been newly prescribed Tysabri, but has not yet started
 taking the medication

 -  Can read and speak English fluently

 Exclusion Criteria:

 -  History of head injury, stroke, seizures, or any other significant neurological event
 other than MS

 -  Flare up of MS symptoms within the past month

 -  History of significant psychiatric illness (for example, bipolar disorder,
 schizophrenia, or psychosis) or a current diagnosis of Major Depressive Disorder

 -  Pacemaker or other implanted electrical device, brain stimulator, aneurysm clip (metal
 clips on the wall of a large artery), metallic prostheses (including metal pins and
 rods, heart valves, and internal hearing aids [cochlear implants]), permanent
 eyeliner, implanted delivery pumps, or shrapnel fragments

 -  Left-handed.

 -  Not able to have an MRI