Persona MC Retained PCL vs. Persona MC Sacrificed PCL vs. NexGen PS
Persona MC Retained PCL vs. Persona MC Sacrificed PCL vs. NexGen PS
This study compares and evaluates differences in movement analysis, patient-reported outcome
 and radiological assesment between patients undergoing total knee arthroplasty with use of
 either Zimmer Biomet NexGen and Zimmer Biomet PERSONA
Osteoarthritis causes the joints to become painful and stiff. Osteoarthritis of the knee is a
 common condition that is expected to be a lot more frequent in the next two decades. As a
 consequence, an increase of total knee replacement surgery is predicted. Total knee
 replacement surgery is offered when knee pain and stiffness caused by osteoarthritis can no
 longer be managed and these symptoms significantly impact on an individual's normal
 activities of daily living. Most total knee replacements are successful but up to 34% of all
 patients have poor functional outcomes following surgery. This leaves affected people at a
 greater risk of reduced physical activity and thus impacts longer-term general health. Poor
 outcomes are therefore of importance to patients and have a considerable financial and
 service-provision impact on National Health Service (NHS) care. While patient-related
 characteristics and their relationship to patient outcomes have been identified, few studies
 have been undertaken to determine how kinematic outcomes (how the prosthetic knee moves) are
 related to functional outcome and patient satisfaction. The kinematic outcome of a total knee
 replacement is hypothesised to relate to both the structural design (shape) of the implant
 and the surgical procedure itself. To date, no studies have investigated the kinematic
 outcomes of different total knee replacement prosthesis designs through a range of typical
 activities of everyday mobility (functional outcomes). Whilst it is known that long term
 success of total knee replacement depends largely upon correct alignment of the prosthesis
 components during surgery, no studies have looked at the anatomical alignments of the
 osteoarthritic knee prior to undergoing surgery (using Computerised Tomography (CT)
 scanning). The aim of the study is to examine relationships between movement analysis
 (kinematic and functional outcomes), patient reported outcome measures (PROMS) and CT
 measurement, both pre- and post-operatively, between two knee prosthesis including one that
 has been designed to improve functional outcomes.
Inclusion Criteria:

 1. Listed for a primary total knee replacement (TKR) at the Orthopaedic and
 Rehabilitation Department Medical University of Warsaw

 2. Indication for the TKR is primary osteoarthritis of the knee joint involving one or
 more compartments

 3. Aged 18 or over

 4. Patient willing to provide full informed consent to the trial

 Exclusion Criteria:

 1. Listed for a single-stage bilateral TKR procedure

 2. Severe symptoms in the contralateral knee so as to require staged bilateral knee
 replacements within 6 months of the primary procedure

 3. Fixed flexion deformity of 15 degrees or greater who will require excessive resection
 of the distal femur

 4. Clinically assessed uncorrectable varus/valgus deformity of 15 degrees or greater

 5. Any co-morbidity which, in the opinion of the investigator, is severe enough to
 present an unacceptable risk to the patient's safety

 6. Inflammatory arthritis

 7. Previous septic arthritis in the affected knee joint

 8. Previous surgery to the collateral ligaments of the affected knee

 9. A contralateral total knee replacement that has been implanted less than one year from
 the date of consultation

 10. A contralateral total knee replacement that is severely painful

 11. Patients on warfarin or novel oral anticoagulants (NOACs)

 12. Will not be resident in the catchment area for at least 6 months post-surgery

 13. Undertaking the surgery as a private patient

 14. Patients who, in the opinion of the clinical staff, do not have capacity to consent

 15. Patients who are pregnant

 16. Unable to understand written and spoken Polish