Treatment of Indolent Systemic Mastocytosis With PA101
Treatment of Indolent Systemic Mastocytosis With PA101
This is a randomized, placebo- and active-controlled, 2-period crossover, 2 cohort study in
 adult patients with indolent systemic mastocytosis (ISM).

 The purpose of the study is to determine the efficacy and safety profile of PA101 delivered
 via eFlow high efficiency nebulizer in patients with ISM who are symptomatic despite using
 standard treatments.
The symptom scores for determining eligibility will be established during the 2-week Run-in
 Period using eDiary and the eligible patients will be randomly allocated in a 2:1 ratio to
 one of two treatment cohorts at the baseline visit.

 In Cohort 1 (n=24), patients will receive inhaled 40 mg PA101 three times daily and inhaled
 placebo three times daily via eFlow for 6 weeks each in a double-blind, 2-period crossover
 fashion with a 4-week washout period between the treatment periods.

 In Cohort 2 (n=12), patients will receive inhaled 40 mg PA101 three times daily via eFlow and
 oral cromolyn sodium 200 mg four times daily for 6 weeks each in an open label, 2-period
 crossover fashion with a 4-week washout period between the treatment periods.

 Patients will be allowed to use the same daily doses of pre-randomization H1 and H2
 antihistamines as well as the same daily doses of any other allowed medications during each
 treatment period.

 Visits during each treatment period will occur at the baseline Visit, and at the end of Weeks
 1, 2, 4, and 6.

 Blood and urine samples will be collected to test for various biomarkers. In a subset of
 patients, additional clinical assessments of the skin will be performed and blood samples
 will be collected for pharmacokinetic assessments. Clinical safety assessments will be
 performed in all patients at the start and end of each treatment period.
Inclusion Criteria:

 -  Diagnosis of indolent systemic mastocytosis (ISM) according to the WHO criteria and
 the consensus proposal (2001)

 -  Experiencing at least one predefined qualifying symptom in at least two organ systems
 within 3 months of Screening despite the use of H1 and/or H2 antihistamines and other
 anti-mediator therapy

 -  Experiencing symptoms with a severity score of at least 4 for at least 7 out of 14
 days during the Run-in period with at least one predefined qualifying symptom each
 from at least two organ systems, despite the use of H1 and/or H2 antihistamines and/or
 other anti-mediator therapy

 -  Willing and able to use an eDiary device daily for the duration of the study

 -  Completed at least 5 eDiary reports during each of two consecutive weeks of the Run-in
 period

 -  Willing and able to provide written informed consent prior to any study procedures

 Exclusion Criteria:

 -  Advanced systemic mastocytosis (i.e., aggressive systemic mastocytosis [ASM], mast
 cell leukemia [MCL], or systemic mastocytosis with an associated clonal hematologic
 non-mast cell lineage disease [SM-AHNMD] )

 -  Current or recent history of clinically significant cardiovascular, hematological,
 renal, neurologic, hepatic, endocrine, psychiatric, malignant, or other illnesses that
 could put the patient at risk or compromise the quality of the study data as
 determined by the Investigator

 -  Use of oral cromolyn sodium within 6 weeks of Screening

 -  History of systemic corticosteroid, immunosuppressive, or anti-IgE monoclonal antibody
 therapy (e.g., omalizumab) within 6 months of Screening

 -  History of anaphylaxis requiring systemic treatment (i.e., corticosteroid or
 epinephrine) within 12 months of Screening

 -  Upper or lower respiratory tract infection within 4 weeks of Screening

 -  History of malignancy within the last 5 years, except basal cell carcinoma or cervix
 carcinoma in situ

 -  Major surgery within 6 months of Screening

 -  Current or recent history (within 12 months) of excessive use or abuse of alcohol

 -  Current or recent history (within 12 months) of abusing legal drugs or use of illegal
 drugs or substances

 -  Pregnant or breastfeeding females, or if of child-bearing potential unwilling to
 practice acceptable means of birth control or abstinence during the study

 -  Participation in any other investigational drug study within 4 weeks of Screening

 -  History of hypersensitivity or intolerance to aerosol medications or cromolyn sodium