GENETIC SUSCEPTIBILITY FACTOR AS A PREDICTOR OF TYPE 2 DIABETES REMISSION AND WEIGHT LOSS AFTER BARIATRIC SURGERY
GENETIC SUSCEPTIBILITY FACTOR AS A PREDICTOR OF TYPE 2 DIABETES REMISSION AND WEIGHT LOSS AFTER BARIATRIC SURGERY
Obesity is directly related to an increased risk of diabetes mellitus, hypertension,
 dyslipidemia, cardiovascular disease, and overall mortality. Weight loss is effective in
 decreasing these risks and to reduce disease severity. Bariatric surgery is an effective
 therapy for sustained weight loss and type 2 diabetes (T2D) remission in most of the morbidly
 obese patients. But there is also a significant number of individuals with an inappropriate
 response to bariatric surgery. Two recent retrospective studies assessed the role of genetic
 load as a predictor of this response, but the results are still unelucidated. The aim of this
 study is to assess whether a selection of genetic variants may allow us to identify
 individuals who will have a satisfactory response after bariatric surgery in terms of weight
 loss and T2D remission.
A retrospective case-control study of 100 women who underwent bariatric surgery (Roux-en-Y
 laparoscopic gastric bypass): 50 pacients who were diabetic before surgery: 15 cases with
 less than 40% of the excess weight loss (EWL) and 35 cases with more than 75% EWL, matched
 with 50 non diabetic controles: 15 patients with less than 40%EWL and 35 with more than
 75%EWL after one year. All individuals were analyzed with a genetic score from Nutri inCode.
 The predictive ability was analyzed by discrimination (area under the ROC curve), sensitivity
 and specificity and a score was calculated.
Inclusion Criteria:

 -  women who underwent a gastric bypass with a minimum of 1 year follow-up,

 -  aged between 18 and 60 years,

 -  stable weight in the previous 6 months,

 -  have signed the informed consent.

 Exclusion Criteria:

 -  male,

 -  with mobility problems that constrain a marked inactivity,

 -  with pathology that limits the practice of within normal limits (chronic obstructive
 pulmonary cardiac cerebral vascular-disease, illness, accident sequel, etc ),

 -  undergoing different surgical techniques to gastric bypass,

 -  with severe psychiatric disorders or eating disorder.