Three-dimensional Study on the Structural Destruction of Pelvic Anatomy in Cervical Cancer
Three-dimensional Study on the Structural Destruction of Pelvic Anatomy in Cervical Cancer
Cervical cancer is one of the most prevalent malignancies in female .To the younger patients,
 radical hysterectomy which is a standard operation during the earlier and middle therapy
 stage as well as more effective technique like radiotherapy and chemotherapy give them a
 longer life expectancy. However, the operation destroys patients' normal pelvic anatomy,
 nutrient supplements and internal secretion so that postoperative pelvic floor functional
 dysfunction has a destructive effect for their life. There are tremendous studies on clinical
 symptoms while few on anatomical changes and the relationship between pelvic floor symptoms
 and the dysfunction. Two-dimensional Magnetic Resonance Imaging(MRI), transperineal
 ultrasonography， Urodynamic examination and anorectal manometry are frequently used in the
 fine-structure varies and pelvic floor function. Now three-dimensional MRI has more
 advantages in fine change of Pelvic anatomical and space position，as well as clearly showing
 the relationships between the change and space with the pelvic floor function. Based on an
 eight-year-study on three-dimensional MRI, we can analyze the postoperational anatomical
 changes and the relationship between the changes and the dysfunction by combined anatomic
 parameters which are measured on static-dynamic three- dimensional model with clinical
 symptoms, transperineal ultrasonography,urodynamic examination and anorectal manometry. We
 expect our study could provide scientific basis for on protective and repaired measures of
 pelvic floor.
Inclusion Criteria： ①Patients diagnosed as FIGO stage IA2、IB1、IIA1 cervical cancer ;
 ②Patients diagnosed as FIGO stage IB2、IIA2 cervical cancer, eligible for RH after
 neoadjuvant chemotherapy; ③Patients diagnosed as FIGO stage IIA endometrial carcinoma;
 ④Patients didn't have pelvic organ prolapse and urinary incontinence; ⑤Ability to hold
 Valsalva for dynamic MRI; ⑥Patients aged 20-70 years; ⑦Patients undergone RH surgery;
 ⑧Informed consent was signed.

 Exclusion Criteria：

 ①With MRI or urodynamic examination contraindication; ②Previously undergone POP or SUI
 surgery; ③BMI>30 With serious postoperative complications.