Improving Scientific Rigor of Renal Clinical Endpoints for Sickle Cell Anemia
Improving Scientific Rigor of Renal Clinical Endpoints for Sickle Cell Anemia
The investigators will attempt to develop a more accurate equation to estimate eGFR in
 pediatric and adult sickle cell patients
200 pediatric and 200 adult SCA participants will undergo mGFR using iohexol at baseline and
 at one year. On the same day, participants will undergo clinical and laboratory variables
 important for developing an eGFR equation. From baseline data, the investigators will perform
 a training and validation cohort of biologically relevant predictor variables to develop a
 novel equation. Then the investigators will compare the novel SCA eGFR equation to the
 established eGFR equation. From one year data, the investigators will determine the
 longitudinal concordance between pediatric and adult novel and standard eGFR equations with
 mGFR and variables that may alter longitudinal inferences.

 In a subset of 30 adult participants, the investigators will also evaluate the correlation
 between mGFR using iohexol and a novel measure of mGFR that is more time efficient
Inclusion Criteria:

 -  SCA patients (HbSS and SB0 thalassemia)

 -  Age: 5.0-50.0 at enrollment

 Exclusion Criteria:

 -  Recent SCA complication associated with hospitalization (within 30 days) or ED visit
 (within 14 days)

 -  Current AKI defined as >0.3mg/g increase in SCr from prior visit

 -  Known history of anaphylaxis with contrast agent or known pregnancy