Heart Attack Research Program: Platelet Sub-Study (HARP)
Heart Attack Research Program: Platelet Sub-Study (HARP)
This prospective observational cohort study, will investigate the platelet phenotype,
 platelet genetic composition, and role of platelets as effector cells in women and men with
 myocardial infarction (MINOCA or MI-CAD) and controls. This study, which will take place at
 NYU and Bellevue Medical Center, and participating external sites. May have concurrent
 enrollment with the HARP Main Imaging (NCT02914483). Additionally, a sex, group of age and
 race matched disease controls 'CATH-NOCA' composed of women and men with stable angina
 referred for cardiac catheterization, will be enrolled. Blood obtained during the initial
 catheterization and 2 months post-MI will be utilized for platelet testing.
Inclusion Criteria:

 -  Acute ischemic symptoms compatible with diagnosis of MI, such as chest pain or anginal
 equivalent symptoms at rest or new onset exertional anginal equivalent symptoms

 -  Objective evidence of MI (either or both of the following):

 -  Elevation of troponin to above the laboratory upper limit of normal (ULN)

 -  ST segment elevation of ≥1mm on 2 contiguous ECG leads

 -  Willing to provide informed consent and comply with all aspects of the protocol

 -  Administration of aspirin at least 1 hour before cardiac catheterization

 -  Administration of thienopyridine (e.g., clopidogrel, ticagrelor) at least 1 hour
 before cardiac catheterization

 -  Women and men with ≥50% of any major epicardial vessel on invasive angiography may
 participate

 Exclusion Criteria:

 -  Recent use of vasospastic agents, such as cocaine, triptans, or ergot alkaloids (≤1
 month)

 -  Alternate explanation for troponin elevation, such as hypertensive urgency, acute
 exacerbation of heart failure, chronic elevation due to kidney disease, pulmonary
 embolism, cardiac trauma

 -  Pregnancy

 -  Thrombolytic therapy for STEMI (qualifying event)

 -  Use of any of the following medications:

 -  Platelet antagonists (except aspirin and thienopyridines) within 7 days

 -  NSAIDs (e.g., ibuprofen, naproxen) within 3 days.

 -  Thrombocytopenia (platelet count <100,000)

 -  Thrombocytosis (platelet count >500,000)

 -  Anemia (hemoglobin <9 mg/dl)

 -  Hemorrhagic diathesis