Clinical Efficacy of Crano-cure inTreatment of Urinary Tract Infection
Clinical Efficacy of Crano-cure inTreatment of Urinary Tract Infection
The main objectives of the study are; to determine the efficacy of test drug Crano-cure for
 the treatment of urinary tract infection, to compare the effectiveness of Polyherbal
 formulation Crano-cure vs. Standard allopathic. Antibacterial/ antibiotic (Ciprofloxacin 500
 mg) in treatment of UTI, to assess the safety of trial drug.

 Research literatures have revealed that Tribulus terrestris (Gokhro), Vaccinium macrocarpon
 (karonda), Cuminum cyminum (Zeera sufaid), Rheum emodi (Revand chini) and Piper cubeba (Kabab
 chini) are important therapeutic plants. Many pharmacological researches have been done on
 these plants. For instance, antioxidant, antiseptic, anti-microbial, anti-bacterial,
 anticancer etc. In the above claims and facts, the study is conducted to formulate and
 evaluate the polyherbal capsule and to find out the most effective combination having
 anti-bacterial activity.
A urinary tract infection (UTI) is the infection of kidney that affects urinary tract. It
 affects the urinary bladder (cystitis) and kidney (pyelonephritis). Symptoms of urinary
 bladder infection are painful urination, frequent micturation, and urinary incontinence.
 Symptoms of infection in kidney include pyrexia and lumber pain also in addition to symptoms
 of a lower urinary tract infection and rarely blood in the urine. In older age and in young
 adults, symptoms may be unclear or non-specific [1].

 Urinary tract infections are grouped into two types; complicated and uncomplicated. In
 uncomplicated cases of urinary tract infections, the function of urinary tract system does
 not disturb. In complicated UTI, the normal function of UT system disturbs [2].

 Uncomplicated UTI is usually caused by E. coli Staphylococcus saprophyticus Klebsiella
 pneumonia Proteus mirabilis Enterococcus spp. While complicated UTI is caused by Similar
 organisms which causes uncomplicated UTI Staphylococcus spp. Enterococcus spp. P. aeruginosa

 Current studies on the prevalence of urinary tract infections approximately one third
 population of the world has been suffering from this disease. This disease causes Pyuria,
 burning urination, heamaturia, pyrexia, Vaginal itching, Offensive" smell and turbid urine,
 urinate frequent, urgency to urinate and suprapubic pain or pain in pelvis. It is not
 life-threatening disease. Different antibacterial/ antibiotics are available such as
 Co-trimaxazole, amoxicillin, nitrofurantoin, trimethoprim, combination of trimethoprim and
 sulfamethoxazole and quinolone antibiotics is taken as a choice for the treatment of UTI [3].
 The antibacterial agents/ antibiotic available but they are limited in number, have adverse
 effects, resistance of bacteria to these agents and relapse of the UTI. In order to overcome
 the problem of less availability of drugs needed to treat urinary tract infection, with
 traditional medicine derived from medicinal plants. This encouraged the search for new and
 dynamic antibacterial agents from plant sources.
Inclusion Criteria:

 -  Age 15 to 60 years with symptomatic acute urinary tract infection.

 -  Willing to participate in the study

 -  Non-pregnant adult females.

 -  Clinical signs and symptoms of a UTI (e.g., dysuria, frequency, urgency to
 urinate, Burning sensations during urination, Hematuria, suprapubic pain) with
 onset of symptoms < 72 hours prior to study entry.

 -  One positive pre-treatment clean-catch midstream urine culture within 48 hours of
 enrollment in the study, defined as > 105 CFU/mL.

 -  Patients having all socioeconomic classes including lower, middle and higher.

 -  In-vitro susceptibility testing of the uropathogen to test and control drug.

 Exclusion Criteria:

 -  • Women who are pregnant, nursing, or not using a medically accepted, effective method
 of birth control. If an antimicrobial agent is to be studied for the treatment of UTI
 in pregnant women, this proposal should be justified, the risk/benefit expectations
 explained, and the issue presented to the division.

 -  Three or more episodes of acute uncomplicated UTI in the past 12 months.

 -  Patients with evidence of factors predisposing to the development of urinary
 tract infections, including calculi, stricture, primary renal disease (e.g.,
 polycystic renal disease), or neurogenic bladder.

 -  Patients with onset of symptoms 96 hours or more prior to entry.

 -  Patients with a temperature > 1010 F, flank pain, chills, or any other
 manifestations suggestive of upper urinary tract infection.

 -  Patients with known or suspected hypersensitivity to the test or control drug.

 -  Patients who received treatment with other antimicrobials within 48 hours prior
 to entry.

 -  Patient suffering in chronic illness Diabetes mellitus, chronic liver diseases