Intervention to Promote Changes of Healthy Lifestyle (Physical Activity and Nutrition) During Gestation
Intervention to Promote Changes of Healthy Lifestyle (Physical Activity and Nutrition) During Gestation
The purpose of this study are:

 -  Assess the impact of an intervention to the adoption of healthy lifestyles among
 pregnant women at high risk of gestational diabetes mellitus on:

 -  weight gain in pregnancy

 -  the levels of maternal and fetal adipokines and

 -  glycemic control maternal and fetal.

 -  Determine whether the adoption of healthy lifestyles in pregnancy is associated with
 epigenetic changes that influence the levels of adipokines and glucose regulation during
 pregnancy and in newborns.
Inclusion Criteria:

 -  be aged ≥ 18 years,

 -  have a pre-pregnancy BMI ≥ 25 kg/m2,

 -  be at risk of developing a gestational diabetes mellitus (a history of gestational
 diabetes mellitus or glucose 1 hour post-50g > 7.1 mmol/L.

 Exclusion Criteria:

 -  Pre-pregnancy diabetes detected in the first trimester (A1c > 6.5%, fasting glucose >
 7.0 mmol/L, random blood glucose> 11.1 mmol/L, glucose > 10.3 mmol/L 1 hour post-50g)

 -  twin pregnancy

 -  taking medications that can affect blood sugar or weight,

 -  practice ≥ 150 minutes of physical activity per week

 -  against formal-indication for physical activity.