Airway Limitation Study: Study In Primary Care Centers Of Chronic Bronchitis In Long-Term Cigarette Smokers Of At Least 40 Years Of Age With Symptoms Of Cough And Shortness Of Breath
Airway Limitation Study: Study In Primary Care Centers Of Chronic Bronchitis In Long-Term Cigarette Smokers Of At Least 40 Years Of Age With Symptoms Of Cough And Shortness Of Breath
The study does not involve testing of a drug (no treatment intervention). The study will will
 use spirometry (breathing tests) in subjects of 40 years of age and older with a history of
 cigarette smoking with chronic bronchitis to check their disease status and whether or not
 they have COPD. Also, study subjects will be asked to complete a questionnaire (to answer a
 list of questions on paper).
Inclusion Criteria:

 - Male or female - ≥40 years of age - Current or previous cigarette smoker with a history
 of cigarette smoking of ≥10 pack/years - Self reported symptoms of chronic bronchitis where
 chronic bronchitis is defined as the presence of productive cough for at least 3 months in
 each of the successive 2 years - Completion of written informed consent prior to study
 participation - Subject must be able to read, comprehend, and record information in
 English.

 Exclusion Criteria:

 - Regular use (i.e., prescribed for use on a daily basis) of the following respiratory
 medications for the six months prior to the study visit: ipratropium, ipratropium/albuterol
 combinations, tiotropium, salmeterol, formoterol, inhaled corticosteroids, inhaled
 corticosteroid/long-acting beta-agonist combinations, theophyllines, oral beta-agonists. -
 Previous lung surgery, including, lung transplant, lung resection, lung volume reduction
 surgery, etc. - Current diagnosis of a significant lung condition other than chronic
 bronchitis, including, asthma, lung cancer, cystic fibrosis, pulmonary fibrosis,
 bronchiectasis, active tuberculosis, sarcoidosis, or alpha-1-antitrypsin deficiency. - Any
 medical or physical condition that would interfere with the adequate performance of
 spirometry. - Evaluation and/or treatment by a pulmonary specialist (e.g., pulmonologist or
 allergist) within 3 years of the study visit. - A spirometrically confirmed diagnosis of
 COPD. - Have, in the opinion of the investigator, evidence of current alcohol, illegal drug
 or solvent abuse. - Limited ability to provide a valid informed consent due to serious
 uncontrolled psychiatric disease, intellectual or cognitive deficiency, poor motivation or
 other relevant condition which in the opinion of the site principal investigator will
 interfere with the subject's participation in the study. - Pregnant females. -
 Participating investigator, sub-investigator, study coordinator, employee of the
 participating investigator or family members of the aforementioned site staffs.