Cerebrovascular EveNts in Patients Undergoing TranscathetER Aortic Valve Implantation With Balloon-expandable Valves Versus Self-expandable Valves.
Cerebrovascular EveNts in Patients Undergoing TranscathetER Aortic Valve Implantation With Balloon-expandable Valves Versus Self-expandable Valves.
The aim of this collaborative analysis is to evaluate stroke rates and mortality in patients
 undergoing TAVI with the self-expandable MCV prosthesis compared to the balloon-expandable ES
 valve. In the absence of large randomized controlled trials, we will conduct a large
 collaborative patient-pooled meta-analysis on 30-day stroke and mortality in patients
 undergoing primary transfemoral TAVI with either MCV or ES valve.
The main aim of this patient-pooled analyses is to compare stroke rates and mortality in
 patients undergoing TAVI with the self-expandable MCV prosthesis compared to the
 balloon-expandable ES valve. However, this collaboration may also be used to compare various
 outcomes.

 Studies were included if they complied with the following requirements: original prospective
 studies, including patients with aortic valve stenosis treated with transfemoral TAVI of
 native valves and reporting of 30 day stroke outcomes according to VARC criteria or other
 specified corresponding criteria . Moreover, to be included studies had to report both the
 use of self-expandable MCV prosthesis and the balloon-expandable ES valve in more than 50
 patients in each arm to ensure experience in use of the valves. Studies were excluded if they
 only addressed patients undergoing valve-in-valve and re-do procedures or bicuspid valves or
 included the same study population. Principal Investigators of these studies were approached
 for collaboration.
Inclusion Criteria:

 -  patients undergoing transfemoral transcatheter aortic valve procedures

 Exclusion Criteria:

 -  valve-in-valve procedures, other acces routes than transfemoral