A Multi-component Intervention to Improve Medication Adherence in People With Depressive Disorders
A Multi-component Intervention to Improve Medication Adherence in People With Depressive Disorders
Objective: The study of medication adherence in depression (MAPDep study) aims to evaluate
 the effectiveness and cost-effectiveness of a multi-component strategy to enhance
 patient-centered care to improve adherence toward medications in patients with depression,
 formed by an educational intervention to psychiatrists and/or a collaborative care
 intervention group to patients and relatives plus a reminder system through the use of a
 mobile APP.

 Methods: The objective will be assessed under an open multicenter, clinical controlled trial
 with random allocation by clusters to one of three interventions or to usual care (control
 arm). In group 1 only patients and family members receive intervention, in group 2 only
 psychiatrists receive intervention, and group 3 is a combined intervention for patients and
 psychiatrists. The main measure will be the change in medication adherence rate. Secondary
 endpoints are depression, emotional distress, health-related quality of life, physical
 functioning, patients' knowledge about their medications, provider beliefs regarding
 patient-centeredness, and healthcare resource utilization.
Inclusion Criteria:

 -  Patients:

 -  Patients with diagnosis of depressive disorder (major depressive disorder MDD
 and/or dysthymia) under pharmacological treatment

 -  Regular users of mobile phones

 -  Patients who have consulted their psychiatrist about their depression at least
 once in the previous 6 months

 -  Health professionals:

 Psychiatrists have no intention of moving from their practice during the study period.

 Exclusion criteria:

 • Patient:

 -  Patients with history of current bipolar disorder and/or any psychotic disorder

 -  Insufficient language skills

 -  Pregnancy