Infectivity of Norovirus in Shellfish Treated With High Hydrostatic Pressure Processing-Human Challenge Study
Infectivity of Norovirus in Shellfish Treated With High Hydrostatic Pressure Processing-Human Challenge Study
Norwalk virus and related "Norwalk-like viruses" are the most common cause of outbreaks of
 stomach sickness (nausea, vomiting, diarrhea) in older children and adults in the United
 States. These viruses are sometimes found in drinking water, ice, shellfish and in other
 foods. They can be spread easily from contact with water, food, objects or hands that have
 even small amounts of feces from someone who was sick.

 The purpose of this research study is to the effectiveness of high hydrostatic pressures
 processing (HPP) treatment on norovirus infected shellfish. Norwalk virus can survive in
 shellfish and still be able to cause sickness. HPP inactivates microorganisms living both on
 the surface and on the interior of the food. The goal of the study is to determine whether
 HPP treatment on oysters spiked with norovirus will reduce infection rates in people
 consuming raw infected oysters.
Inclusion Criteria:

 -  Normal healthy volunteer

 -  Age must be between 18 and 50 years of age

 Exclusion Criteria:

 -  Have a job in which you handle food

 -  Are a health care worker with direct patient contact

 -  Work in a child care, elderly care center or if you live with young children or anyone
 who has a weak immune system

 -  Are not willing or able to wash your hands every time after you go to the bathroom, or
 before and after you prepare or handle food throughout the whole study

 -  Are anemic

 -  Are not willing to give us permission to store and use your data and samples