The Effect of Intensive Multifactorial Therapy on Endothelial Function in Newly Diagnosed Type 2 Diabetes
The Effect of Intensive Multifactorial Therapy on Endothelial Function in Newly Diagnosed Type 2 Diabetes
The endothelial dysfunction is the early event in atherosclerosis. The investigator previous
 study showed that impaired endothelial function exist in newly diagnosed type 2 diabetes. The
 investigators hypothesize that intensive multifactorial therapy including intensive blood
 control and intensive hypertension control as well as intensive blood lipids control of 1
 year can improve vascular endothelial function. Moreover, the improvement of endothelial
 function maintains after 5 years or 10 years of intensive multifactorial therapy, called
 "Metabolic Memorial Effect of improvement of endothelial function".
-  We select 1000 patients with newly diagnosed type 2 diabetes. They are divided into two
 groups, respectively (Intensive multifactorial therapy and conventional multifactorial
 therapy groups). After those therapy for one year, a 10 years of follow up study will be
 performed. During this period, we take them together intensive education, and take
 conventional multifactorial therapy for both of two groups.

 -  At the beginning (0 year),the end of intensive multifactorial therapy (1 year), 5 years
 and 10 years, we will measure the endothelium-dependent arterial dilation, endothelium
 related cytokines such as ET-1, vWF,as well as blood glucose, HbA1c for all of
 individuals.

 -  We will compare the endothelial function,endothelium related cytokines such as ET-1,
 vWF,as well as blood glucose, HbA1c between intensive therapy group and conventional
 therapy group at different time points.
Inclusion Criteria:

 -  Newly diagnosed type 2 diabetes,

 -  Age: 40 >= age <=70 year old,

 Exclusion Criteria:

 -  Type 1 diabetes,

 -  Mitochondrial diabetes

 -  Patients with clinical detectable angiopathy,

 -  Body Mass Index (BMI) > 30 Kg/m2,

 -  Age < 40, or > 70 years old,

 -  Malignant neoplasms, renal or liver diseases,

 -  Smokers

 -  Known diabetes