Molecular Epidemiology of Acute Myelogenous Leukemia
Molecular Epidemiology of Acute Myelogenous Leukemia
Little is known about the epidemiologic risk factors associated with the development of acute
 myelogenous leukemia (AML), and less is known about the role that genetic susceptibility
 plays in the development of AML. We propose to conduct a population-based study to
 investigate genetic susceptibility in adult AML patients, both de novo and treatment-related
 in a well-defined geographical area. Using a case-control design, we will prospectively
 enroll 400 patients from Texas and 800 healthy controls. Controls will be recruited using
 random digit dialing, and will be matched to the cases by age, gender, and ethnicity.
 Epidemiological and demographic information will be obtained through personal interviews, and
 will be integrated with clinical information, cytogenetic data, and genotypic markers. Blood
 specimens will be collected on all participants, who will be genotyped for markers associated
 with activation and detoxification of chemical carcinogens, including chemotherapy drugs.
 Polymorphisms in genes such as cytochrome p450 (CYP2E1), glutathione S-transferases (GSTT1,
 GSTM1, GSTP1), epoxide hydrolase (HYL1), NADPH-quinone oxidoreductase (NQO1), and
 myeloperoxidase (MPO) will be analyzed.

 This study will provide insight into the role that these susceptibility markers, along with
 clinical epidemiological, and cytogenetic factors, play in the identification of people at
 risk of developing AML. Understanding how genetic predisposition and exogenous exposures
 interact to determine AML susceptibility will allow the development of prevention strategies
 in the future.
INFORMED CONSENTS FOR AML PATIENTS:

 For this study, participant will be asked to complete a personal interview. During the
 interview, participant will be asked questions about participant's demographics (age, sex,
 etc.), any chemicals participant may have been exposed to, participant's medical history,
 family history of cancer, participant's diet, and participant's smoking and alcohol use
 histories. It should take around 50 minutes to complete the interview.

 Participant will also have around 1 tablespoon of blood drawn for special tests. These tests
 will look for any biologic factors associated with AML.

 The interview and the blood draw may be done during a regularly scheduled visit to M. D.
 Anderson, or may be scheduled at the time and place of participant's convenience.

 Participant may be contacted at home by phone so that researchers can collect information
 about any changes in participant's health status.

 This is an investigational study. Up to 1,200 participants will take part in this study.

 INFORMED CONSENT FOR CONTROL SUBJECTS:

 For this study, participant will be asked to complete a personal interview. During the
 interview, participant will be asked questions about participant's demographics (age, sex,
 etc.), any chemicals participant may have been exposed to, participant's medical history,
 family history of cancer, participant's diet, and participant's smoking and alcohol use
 histories. It should take around 50 minutes to complete the interview.

 Participant will also have around 1 tablespoon of blood drawn for special tests. These tests
 will look for any biologic factors associated with AML. The interview and blood draw will be
 scheduled at the time and place of participant's convenience.

 This is an investigational study. Up to 1,200 participants will take part in this study.
Inclusion Criteria:

 1. A histologically confirmed diagnosis of AML (patients only)

 2. Aged 18 or older

 3. Resident of Texas

 4. Willing and able to provide written informed consent and authorization

 5. Willing to donate 10mL of blood and complete a personal interview

 Exclusion Criteria:

 1. Under 18 years of age

 2. History of invasive cancer, excluding non-melanoma skin cancer (controls only)