Adjuvant Chemoradiation With Weekly Oxaliplatin in Resected Head and Neck Cancer
Adjuvant Chemoradiation With Weekly Oxaliplatin in Resected Head and Neck Cancer
Oxaliplatin-containing regimens have been safely and successfully used in combination with
 concurrent radiation in treatment of solid tumors such as rectal and esophageal cancers. The
 Lyon R0-04 phase II trial utilized the combination of Oxaliplatin, infusional 5-fluorouracil
 (5-FU) and radiation in the treatment of rectal cancer. The trial showed a combined
 preoperative chemoradiotherapy and Oxaliplatin-containing regimen is well tolerated with no
 increase surgical toxicity. The good response rate observed warrants its use in further
 clinical trials.

 The combination of oxaliplatin, 5-FU, and radiation also have been used in a Phase I/II trial
 in esophageal cancer. In this particular trial, eligibility included therapeutically naïve
 esophageal cancer subjects with clinical disease stages II to IV. Initial doses and schedules
 for cycle 1 consisted of Oxaliplatin 85 mg/m2 on days 1, 15, and 29; continuous infusion of
 5-FU 180 mg/m2 for 24 hours for 35 days; and radiation therapy (RT) 1.8 Gy in 28 fractions
 starting on day 8. At completion of cycle 1, eligible subjects could undergo an operation or
 begin cycle 2 without RT. Postoperative subjects were eligible for cycle 2. Stage IV subjects
 were allowed three cycles in the absence of disease progression. 38 subjects were treated (22
 stage IV, 16 stage II-III). 38 eligible subjects received therapy: 22 non-invasively staged
 as IV and 16 non-invasively staged as IV and 16 non-invasively staged as II and III. 36
 subjects completed cycle 1, 29 subjects started cycle 2, and 24 subjects completed cycle 2.
 The combined-modality therapy was well tolerated, but dose limiting toxicity (DLT) prevented
 Oxaliplatin and 5-FU escalation. No grade 4 hematologic toxicity was noted. Eleven grade 3
 and two grade 4 clinical toxicities were noted in eight subjects. After cycle 1, 29 subjects
 (81%) had no cancer in the esophageal mucosa. 13 subjects underwent an operation with intent
 to resect the esophagus and 5 subjects (38%) exhibited pathologic complete responses. There
 was no surgical mortality. Only 1 subject developed post-operative tracheoesphageal fistula.
 The results of these trials described above indicated that combination of oxaliplatin and
 radiation is safe and efficacious and dose not compromise surgical wound healing, repair and
 clinical outcome.
Adjuvant treatment of resected head and neck cancers The incidence of locoregional failures
 and distant metastasis is high after primary resection of squamous cell carcinoma of the head
 and neck (HNSCC), especially in patients with unfavorable prognostic factors such as residual
 disease, histological evidence of extracapsular spread, and/or multiple neck nodes. RT is
 indicated as an adjuvant therapy to surgery. In the past 2 decades, RT was mainly delivered
 post-operatively, and the therapeutic gain with this combination is now well documented.
 Despite an overall 2-year freedom of recurrance of approximately of 70-75%, survival rates
 are usually poor in the whole HNSCC patient population, and they usually do not exceed 30 to
 35% at 5 years. The incidence of metastases in locally advanced but resectable head and neck
 cancer can reach 15 to 20%. The role of systemic chemotherapy has been tested in clinical
 trials to determine if the addition of chemotherapy can decrease locoregional and distant
 failure and improve survival.

 Oxaliplatin and radiation in solid tumors Oxalipaltin-containing regimens have been safely
 and successfully used in combination with concurrent radiation in treatment of solid tumors
 such as rectal and esophageal cancers. Results of previous trials indicated that combination
 of oxaliplatin and radiation is safe and efficacious and dose not compromise surgical wound
 healing, repair and clinical outcome.

 Oxaliplatin and radiation in head and neck cancer Oxaliplatin and radiation has been used in
 a randomized phase II study comparing standard radiation with or without weekly oxaliplatin
 in the treatment of locally advanced nasopharyngeal carcinoma. Radiation was administered at
 70-74 Gy to the primary tumor site, 60-64 Gy to the involved areas of the neck and 50 Gy to
 the uninvolved area of the neck. Chemotherapy with oxaliplatin at 70 mg/m2 was given weekly
 for 6 courses with standard radiation in the investigational arm. Interim results concurrent
 radiation with weekly oxaliplatin resulted in a higher complete response in the primary tumor
 site and in the cervical lymph nodes. There was no difference in the incidences of dry mouth,
 stomatitis, skin reaction, peripheral neuropathy or hematological toxicities between the 2
 treatment arms. Patients receiving the concurrent radiation and oxaliplatin treatment did
 experience more gastrointestinal toxicities mostly nausea and vomiting. The only grade 3
 toxicities are thrombocytopenia (5.1%), nausea/vomiting (12.8%) and skin reaction (25.6%).

 Microscopically involved margins, involvement of two or more nodes, extracapusular spread,
 presence of perineural involvement, and vascular embolisms are associated with an
 approximately 25% to 30% probability of developing locoregional failure. The addition of
 cisplatin to radiation reduces the locoregional failure and distant metastasis. We propose to
 investigate the toxicities of using weekly oxaliplatin with radiation in the treatment of
 high risk resected head and neck patients since oxaliplatin has a better side effects
 profile. The high risk factors will be the same criteria utilized in both RTOG 9501 and EORTC
 22931. They include microscopically involved margins, involvement of two or more nodes,
 extracapusular spread, presence of perineural involvement, vascular embolisms, and oral
 cavity or oropharyngeal carcinoma with lymph nodes metastasis at level IV or V.
Inclusion Criteria:

 -  All subjects must have histologically or cytologically confirmed diagnosis of squamous
 cell carcinoma of the head and neck region. Primary tumor sites include: oral cavity,
 pharynx (oropharynx, hypopharynx), or larynx (supraglottis, glottis subglottis).
 Nasopharynx primary will be excluded.

 -  The resected tumor must have one or more of the following high risk features:
 histologic extracapsular nodal extension involvement of ≥ 2 regional lymph nodes,
 mucosal margin of resection with invasive cancer (limited to microscopic detection
 only), tumor with perineural invasion, tumor with lymphovascular invasion, oral cavity
 and oropharynx carcinomas with positive lymph nodes metastasis at level IV or V.

 -  Radiation must begin within 28 to 56 days after surgical resection.

 -  All subjects must be 18 years of age or older.

 -  Subjects must have a Zubrod performance of 0-2.

 Exclusion Criteria:

 -  Subjects must not have distant metastatic disease (M1).

 -  Subjects must NOT have prior therapy with oxaliplatin.

 -  Subjects with any evidence of active or uncontrolled infection, recent myocardial
 infection, unstable angina, or life-threatening arrhythmia are not eligible.

 -  Patients with severe psychiatric disorder are not eligible.

 -  No other prior malignancy is allowed except for adequately treated basal cell or
 squamous cell carcinoma, in situ cervical cancer, or adequately treated Stage I and II
 cancer from which the patient is in complete remission, or any other malignancy from
 which the patient has been disease-free for 5 years.