LYS228 PK, Clinical Response, Safety and Tolerability in Patients With Complicated Urinary Tract Infection (cUTI)
LYS228 PK, Clinical Response, Safety and Tolerability in Patients With Complicated Urinary Tract Infection (cUTI)
The purpose of the study is to evaluate whether LYS228 can be developed for the treatment of
 complicated urinary tract infections
Inclusion Criteria:

 -  Male and female patients 18 to 85 years of age with suspected and/or bacteriologically
 documented complicated UTI judges by the investigator to be serious (required patient
 to be hospitalized for treatment with intravenous antibiotics)

 Exclusion Criteria:

 -  Urine Gram stain that demonstrated that a Gram-positive organism was present, or if
 urine culture results were available, demonstrated Gram- positive organisms were
 present at ≥10E5 CFU/mL

 -  Urine culture result available at enrollment and demonstrating more than 2 different
 species of microorganisms regardless of the colony count

 -  Urine culture result available demonstrating fungal UTI with colony count >10E3 CFU/mL

 -  Patient had received prior antibiotics within 72 hours before the initiation of study
 therapy

 -  Patients with estimated glomerular filtration rate < 30mL/min calculated based in
 study qualified formula