Somatropin Treatment in Patients With SHOX Deficiency and Turner Syndrome
Somatropin Treatment in Patients With SHOX Deficiency and Turner Syndrome
This clinical trial will compare the mean first year height velocity of somatropin-treated
 prepubertal patients with SHOX deficiency with the height velocity of a control group of
 untreated prepubertal patients with SHOX deficiency. Both groups will be compared to a
 somatropin-treated group of girls with Turner syndrome. After the second year patients in the
 control group have the option to receive treatment as well. All patients will optionally be
 treated until they achieved adult height.
Inclusion Criteria:

 -  Turner Syndrome or SHOX disorder

 -  SHOX: bone age greater than 10 years for boys, greater than 8 years for girls, Turner:
 bone age greater than 9 years

 -  Height below 3rd percentile or height below 10th percentile and growth velocity below
 25th percentile

 -  Prepubertal: For girls, Tanner stage 1, for boys Tanner stage 1 and testicular volume
 no more than 2 mL

 Exclusion Criteria:

 -  GH deficiency or known insensitivity

 -  Evidence of tumor activity

 -  Diabetes mellitus or history of impaired glucose tolerance

 -  Any severe illness known to interfere growth