Lowering Blood Pressure by Changing Lifestyle
Lowering Blood Pressure by Changing Lifestyle
Introduction: High blood pressure is an independent risk factor of cardiovascular disease
 (CVD) and is a major cause of disability and death. Managing a healthy lifestyle has been
 shown to reduce blood pressure and improve health outcomes. We aim to investigate the
 effectiveness of a lifestyle modification intervention program for lowering blood pressure in
 a rural area of Bangladesh.

 Methods and analysis: A single-centre cluster randomized controlled trial (RCT). The study
 will be conducted for six months, a total of 300 participants of age 30 to 75 years with 150
 adults in each of the intervention and the control arms. The intervention arm will involve
 the delivery of a blended learning education program on lifestyle changes for the management
 of high blood pressure. The education program comprises evidence-based information with
 pictures, fact sheets, and published literature about the effects of high blood pressure on
 CVD development, increased physical activity and the role of a healthy diet in blood pressure
 management. The control group involves providing information booklets and general advice at
 the baseline data collection point. The primary outcome will be the absolute difference in
 clinic systolic and diastolic blood pressure. Secondary outcomes include the difference in
 the percentage of people adopting regular exercise habits, cessation of smoking and reducing
 sodium chloride intake, health literacy of all participants, the perceived barriers and
 enablers to adopt behaviour changes by collecting qualitative data. Analyses will include
 analysis of covariance to report the mean difference in blood pressure between the control
 and the intervention group and the difference in change in blood pressure due to the
 intervention.
High blood pressure is a fundamental cause of cardiovascular disease (CVD) and a major cause
 of disability and death. Raised blood pressure accounts for as many as 10.4 million deaths
 per year globally. The prevalence of high blood pressure has increased from 87.0 million in
 1999-2000 to 108.2 million in 2015-2016. Of the 1.5 million worldwide annual deaths, 9.4% has
 been attributed to high blood pressure. Modifiable risk factors such as smoking, unhealthy
 diet and physical inactivity are shared and established risk factors for CVDs. Lifestyle
 changes such as smoking cessation, diet alteration including a reduction in dietary sodium
 intake and increased physical activity can improve health outcomes by decreasing or slowing
 complications associated with high blood pressure and other CVDs.

 Development and subsequent evaluation of effectiveness for any intervention targeting high
 blood pressure should include core components comprising baseline participant assessment,
 educational interventions for participants to acquire adequate knowledge about the etiology
 and risk factors of hypertension, and modification of lifestyle factors such as participating
 in regular physical activity, consuming a healthy diet and smoking cessation. Despite the
 high prevalence of high blood pressure in low-income and middle-income countries, there are
 relatively few data on intervention programs from low-income and middle-income countries
 (LMICs). Studies also report that a significant proportion of people with high blood pressure
 are undiagnosed or do not meet targets to control blood pressure both in developed and in
 LMICs. Among people with known high blood pressure, less than one-third of people are able to
 control their high blood pressure with appropriate treatment. Lifestyle modification programs
 have been shown to be effective in controlling blood pressure in LMICs.

 Bangladesh, a low-income country in South East Asia, is currently confronting an increasing
 burden of chronic diseases, including high blood pressure. Islam et al. conducted a
 cross-sectional study among adults age ≥30 years in a rural district in Bangladesh that
 reported the knowledge, attitudes and practice of diabetes and common eye diseases, and found
 overall knowledge was below average. The study also reported the prevalence and risk factors
 associated with known and undiagnosed diabetes, and self-reported known high blood pressure
 and newly diagnosed high blood pressure. The study identified that 40% of adults had high
 blood pressure, of which 82% were previously undiagnosed. Almost 60% of those with high blood
 pressure also had diabetes.

 Recently, a community-based cluster randomized controlled trial was conducted in rural
 communities in Bangladesh, Pakistan and Sri Lanka. This multicomponent intervention program
 was conducted for 24 months in 2645 adults with hypertension defined as blood pressure
 greater than or equal to 140/90 mm Hg. The study reported a statistically significant mean
 reduction of systolic blood pressure of 5.2 mm Hg from the baseline mean blood pressure 146.7
 mm Hg compared to the usual care in which the reduction was 3.9 mm Hg. Relatively small
 reductions of 2 mm Hg in SBP and DBP have been reported to lower the risk of stroke by 14%
 and 17%, respectively, and the risk of coronary artery disease by 9% and 6%, respectively.
 The intervention program included home visits by government community health workers for
 blood-pressure monitoring and counselling and the training of physicians. A possible
 limitation of this intervention program maybe that home visits by trained community health
 workers for blood pressure monitoring and counselling may not be a sustainable and
 cost-saving approach due to the shortage of qualified workforce and the budget constraints in
 low- middle-income countries. Application of blended learning education programs to educate
 patients in managing blood pressure by changing lifestyle and participation in intervention
 programs as volunteers coordinated by volunteer leaders may be a sustainable approach for
 lowering blood pressure in the community setting. The goal of this pilot study is to compare
 a multicomponent intervention program to evaluate its effectiveness for lowering blood
 pressure among adults with high blood pressure in a rural district in Bangladesh.

 Health literacy is a complex and combined perception comprising a range of attributes
 including available resources of health-related information, and an individuals'
 intellectual, emotional, social and personal skills. Health literacy empowers people with
 skills to improve their health and well-being. Evidence indicates that deficits in health
 literacy are associated with poorer health outcomes and higher health-related costs at both
 individual and system levels. Improved health literacy had been reported to be associated
 with reductions in risk behaviours for chronic disease. However, an extended and often
 asymptomatic onset and a need for ongoing management, these conditions present people with a
 sharp and upward learning curve about risks, treatments and self-care. Self-care, especially
 in resource-limited settings, an essential dimension of treatment, depends on the ability of
 systems and providers to teach and patients to learn effective self-management skills. At the
 individual level, good health literacy is the foundation of successful management and
 prevention of chronic disease. Health literacy assessment can be used to improve community
 participation in health, health service planning, public health education, and policy
 development. In the past decade, much research on the impact of health literacy on health
 outcomes has been conducted across the globe; however, health literacy tools in rural areas
 of Bangladesh have not been developed or tested. The European Health Literacy Survey (HLS-
 Q12) questionnaire has been used to assess health literacy; however, its usefulness to
 measure health literacy in rural Bangladesh has not been investigated.
Inclusion Criteria:

 -  Participants with clinic blood pressure more than or equal to 130/80 mm Hg who are not
 taking medication

 -  Participants with controlled blood pressure defined as < 130/80 using
 anti-hypertensive medication for a minimum of six weeks.

 -  Participants live in Banshgram Union only

 Exclusion Criteria:

 -  Aged > 75 years of age

 -  Pregnant women

 -  People who have advanced CVDs or are any serious condition that restricts their
 participation in the study

 -  Participants will be withdrawn from the study if they are unwilling to continue their
 participation and withdraw their consent, or any women participants who become
 pregnant during the study.