Effect of Normobaric Hypoxia and Hyperoxia in Patients With Pulmonary Hypertension
Effect of Normobaric Hypoxia and Hyperoxia in Patients With Pulmonary Hypertension
Pulmonary Hypertension (PH) is a severe disease with a bad prognosis. However, thanks to
 extensive research in this field, there are more and better treatment options that allow
 patients to participate in recreational activities at moderate altitude or bring up the
 question of air-travel.

 Still very few is known about the effects hypoxic conditions have on PH patients. The aim of
 this study is to investigate the effects of hypoxia in comparison to normoxia and hyperoxia
 on pulmonary hemodynamics in patients with pulmonary hypertension during routine right heart
 catheterisation. We aim to get insight into the pathophysiology of pulmonary hemodynamics
 under hypoxic conditions in comparison to normoxia and hyperoxia in patients with pulmonary
 arterial and chronic thromboembolic pulmonary hypertension compared with control patients,
 that are scheduled for right heart catheterisation due to dyspnea but have no PH.
Inclusion Criteria:

 -  clinically indicated right heart catheterisation

 -  diagnosis of pulmonary arterial hypertension or chronic thromboembolic pulmonary
 hypertension or control without pulmonary hypertension

 Exclusion Criteria:

 -  hemodynamically unstable

 -  partial pressure of Oxygen < 7.3kPa

 -  no informed consent

 -  pulmonary hypertension due to left heart disease, chronic lung disease or
 miscellaneous (Groups II, III and V) according to Galié ERJ 2015