Growth and Weight Gain in ELBW Infants Fed an Exclusively Human Milk Based Diet With Prolacta®
Growth and Weight Gain in ELBW Infants Fed an Exclusively Human Milk Based Diet With Prolacta®
Preterm infants are susceptible to postnatal growth restriction. Breast milk is the
 recommended source of nutrition for preterm infants. As preterm infants have enhanced
 nutritional requirements, multicomponent fortifiers are added to breast milk in order to
 establish adequate growth.

 Due to the various benefits of human milk feds to preterm infants, a human milk fortifier
 based on donor milk (Prolact+6 H2MF® Prolacta, City of Industry, California) has been
 developed. With this study, the investigators want to evaluate the effect of human milk
 fortification on weight gain in extremely low birth weight infants (ELBW, <1000g birth
 weight) in comparison to bovine fortification.
Preterm infants are susceptible to postnatal growth restriction. Breast milk is the
 recommended source of nutrition for preterm infants. Many positive short-term health effects
 like prevention necrotizing enterocolitis , effects on gut development and immunological
 issues are associated with breast milk feedings.

 The composition of breast milk usually meets the nutritional demands of term infants. As
 preterm infants have enhanced nutritional requirements, multicomponent fortifiers are added
 to breast milk in order to establish adequate growth and proper neurodevelopmental outcome.

 Due to the various benefits of human milk feds to preterm infants, a human milk fortifier
 based on donor milk (Prolact+6 H2MF® Prolacta, City of Industry, California) has been
 developed. This human milk fortifier contains more energy and protein than bovine milk
 fortifiers. So far, accurate data on growth and weight gain under an exclusive diet with
 human milk and the human milk fortifier Prolact+6H2MF®are missing. With this study, the
 investigators want to evaluate the impact of a human milk based fortifier on weight gain in
 extremely low birth weight infants (ELBW, <1000g birth weight) in comparison to bovine milk
 based fortifier.
Inclusion Criteria:

 -  Preterm infants with a birth weight <1000 g

 Exclusion Criteria:

 -  Congenital heart disease

 -  Major congenital birth defects

 -  Major inborn error of metabolism