Amiloride Solution and Tobramycin Solution for Inhalation for the Eradication of Burkholderia Dolosa in Patients With Cystic Fibrosis
Amiloride Solution and Tobramycin Solution for Inhalation for the Eradication of Burkholderia Dolosa in Patients With Cystic Fibrosis
The purpose of this research study is to determine if multiple doses of two inhaled drugs
 will help Cystic Fibrosis patients whose lungs are infected with a bacteria called
 Burkholderia dolosa. The names of these drugs are tobramycin solution for inhalation and
 amiloride solution for inhalation. Currently, treating patients with Burkholderia dolosa
 infections is challenging because the bacteria is resistant to antibiotics. Therefore,
 researchers are looking for drugs which, when taken with an antibiotic, will help the
 antibiotic to work more effectively.
Inclusion Criteria:

 -  Diagnosis of Cystic Fibrosis

 -  Two positive cultures for Burkholderia dolosa lung infection

 Exclusion Criteria:

 -  Positive pregnancy test or currently breast feeding (if applicable)

 -  Known sensitivity to Amiloride