Diagnosis of Cow's Milk Protein Allergy Among Infants and Children in Assuit University Children Hospital
Diagnosis of Cow's Milk Protein Allergy Among Infants and Children in Assuit University Children Hospital
The study will assess the diagnosis of Cow's milk protein allergy (CMPA) among infant and
 children in Assiut University Children Hospital using skin prick test and specific serum IgE
Food allergy is a reproducible specific immune response to the exposure to a given food.
 Cow's milk protein allergy (CMPA) is a clinically abnormal reaction to cow's milk protein
 (CMP) via immune mechanisms triggered by milk protein (Boyce etal., 2010) .

 According to the European Academy for Allergy and Clinical Immunology (EAACI) and the World
 Allergy Organization (WAO), a hypersensitivity reaction to cow's milk involving the immune
 system can be called as CMPA.There is difference between CMPA and non-allergic cow's milk
 intolerance (e.glactose intolerance) which occurs as a result of lactase deficiency without
 involvement of the immune system (Venter etal ., 2013) .

 CMPA is categorized into immunoglobulin IgE mediated, non-IgE mediated, or mixed
 CMPA(Sichereretal ., 2001) .

 1.9% to 4.9% prevalence of CMPA among children with a peak in prevalence (2-3%) in the first
 year of life and prevalence of <1% in children aged ≥6 years(Koletzkoetal ., 2012) .
Inclusion Criteria:

 1. age : from first day of life - 2 years

 2. exclusively breast feeding,breast-fed infants with supplementary foods and
 non-breast-fed infants with supplementary foods who complain from either
 frequentregurgitation,vomiting,diarrhea,constipation)with/without perianal
 rash),bloodin stool or pallor.

 Exclusion Criteria:

 -  Infant and child with gastrointestinal symptoms due to specific aetiology .