Conduction System Pacing International Registry (CONSPIRE Registry)
Conduction System Pacing International Registry (CONSPIRE Registry)
The purpose of this registry study is to collect information about routine clinical practices
 with device implantation to treat bradycardia and cardiac systolic dysfunction (heart rhythm
 disorders) across global centers of excellence in cardiac pacing. In particular, this study
 will examine the use of conduction system pacing (CSP) in clinical practice. Information
 collected in the registry will help researchers better characterize strengths and limitations
 of current technology and treatments.
During this past decade, there has been a dramatic surge in interest in new physiologic
 pacing strategies which engage and take advantage of the intrinsic cardiac conduction system.
 These approaches include His bundle pacing (HBP) as well as approaches which seek to pace the
 proximal left conduction system (LCS), including left bundle branch area pacing (LBBAP) or
 pacing in the region of the left posterior fascicle. Left ventricular septal pacing (LVS) has
 also been proposed as another means to avoid dyssynchrony with early data suggestive of
 comparable electrical synchronization as biventricular pacing. These approaches utilize
 approved pacing systems and leads which are delivered to new targets in the His-Purkinje
 system or LV endocardial fibers. Despite the growing interest in HBP, LCS, and LVS, the
 majority of data are from disparate cohort studies and there has been a lack of uniformity in
 assembling data or analyzing and interpreting outcomes.

 The goal of the Conduction System Pacing International Registry (CONSPIRE) is to
 systematically and prospectively collect data across multiple centers of excellence on the
 early implementation of permanent conduction system pacing devices in order to characterize
 strengths and limitations of current technology. The study will evaluate patient selection,
 intraprocedural characteristics, and clinical outcomes among patients receiving conduction
 system pacing (CSP) as part of their routine clinical care.
Inclusion Criteria:

 -  Meets American College of Cardiology (ACC)/American Heart Association (AHA)/Heart
 Rhythm Society (HRS) guidelines for bradycardia, or

 -  Meets ACC/AHA/HRS guidelines for cardiac resynchronization therapy (CRT).

 Exclusion Criteria:

 -  Age < 18 years

 -  Inability of patient capacity to provide consent for themselves either due to medical
 or psychiatric comorbidity

 -  Pregnancy

 -  Difficulty with follow-up