Natural History of Liver Cirrhosis Diagnosed by Transient Elastography in HIV/HCV-coinfected Patients
Natural History of Liver Cirrhosis Diagnosed by Transient Elastography in HIV/HCV-coinfected Patients
Prospective multicenter cohort recruiting consecutive patients from 7 hospitals in Andalusia,
 southern Spain, according to following criteria: 1) HIV infection, 2) Chronic active HCV
 infection, 3) Older than 18 years, 4) New diagnosis of liver cirrhosis on the basis of a
 liver stiffness above 14 kiloPascals, 5) No previous or concomitant decompensation of liver
 disease. Patients are prospectively followed-up according to a uniform protocol of care.
 Epidemiological, clinical and laboratory variables are periodically recorded. The primary
 outcomes are the emergence of a liver decompensation (including hepatocellular carcinoma),
 liver transplant or death. The predictors of these outcomes are analyzed.
Inclusion Criteria:

 -  HIV Infection

 -  HCV chronic active infection (positive serum RNA HCV at inclusion)

 -  New diagnosis of cirrhosis on the basis of a liver stiffness equal or greater than 14
 kiloPascals.

 -  No previous or concomitant decompensation of liver disease

 Exclusion Criteria:

 -