The Change of the Tetanus Antibody Titer After Single Injection of Td and Simultaneous Injection of TIG With Td
The Change of the Tetanus Antibody Titer After Single Injection of Td and Simultaneous Injection of TIG With Td
The investigators want to determine whether TIG influences the formation of tetanus antibody
 after simultaneous tetanus vaccination according to age and the time-interval of the last
 tetanus vaccination.
When an injured patient visits the ED, unnecessary injection of tetanus immunoglobulin (TIG)
 may cause side effects and also increase the medical expense.5 Further, the opportunity of
 assessing a rising tetanus antibody titer may be missed after simultaneous injection of
 tetanus-diphtheria vaccine (Td) and TIG. According to age, the elevation of the tetanus
 antibody titer after tetanus prophylaxis might be not equivalent because of different levels
 of basal immunity and the time-interval of the last tetanus vaccination. Therefore, we wanted
 to determine whether TIG influences the formation of tetanus antibody after simultaneous
 tetanus vaccination according to age and the time-interval of the last tetanus vaccination.
Inclusion Criteria:

 -  healthy adult volunteers

 Exclusion Criteria:

 -  immunocompromised

 -  febrile

 -  allergy to the vaccine constituents

 -  previous tetanus immunization within 5 years

 -  medical and non-medical employees