Org 24448 to Treat Major Depression
Org 24448 to Treat Major Depression
This study will evaluate the effectiveness of the experimental drug, Org 24448, for
 short-term treatment of depression. It will examine the effects of the drug on symptoms, such
 as low mood and persistent sadness, poor sleep and appetite, poor motivation and lack of
 enjoyment of things people normally enjoy, negative thinking, and feeling slowed down or
 having trouble concentrating. It will also assess whether the drug improves cognitive
 function, especially memory.

 Patient with major depression who do not have a serious, unstable medical illness and who are
 21 to 55 years of age may be eligible for this study. Candidates are screened with a
 psychiatric and medical history, diagnostic interview, physical examination,
 electrocardiogram, blood tests and, for women, a pregnancy test.

 Participants are tapered off anti-depression drugs (and any other medications not allowed on
 the study) over a 3-week period and then begin a 2-week drug-free period. During these 2
 weeks they have an electroencephalogram (EEG) with light stimulation, and those whose EEG
 indicates a seizure disorder are excluded from the study. Also at the beginning of the
 drug-free period they begin taking a placebo ("sugar pill") twice a day. After 2 weeks on
 placebo, some patients begin treatment with Org 24448, while others remain on placebo. They
 continue the medication for 8 weeks, during which time they have a weekly check of vital
 signs, blood and urine tests, and rating scales for depression and anxiety. Level of
 functioning is evaluated twice during the study. After 8 weeks of treatment, patients have a
 physical exam, electrocardiogram (ECG), EEG, blood tests, and begin to come off the study
 drug, tapering the medication over a week.

 In addition to the above procedures, some patients undergo the following tests during the
 2-week drug-free period and again toward the end of the 8-week medication phase:

 -  Neuropsychological testing, including measurements of cognitive abilities such as
 memory, attention, problem-solving, and language skills.

 -  Positron emission tomography (PET): This nuclear medicine test provides information
 about different brain regions. The patient lies on a table in the PET scanner (similar
 to a computed tomography (CT) scanner), with a mask placed over his or her face that
 helps keep the head still. A sugar fluid with a radioactive material attached to it is
 injected into a catheter (plastic tube) that has been inserted into a vein in the
 patient's arm. The scanner detects ...
Depression is a devastating illness that is estimated to affect 12% to 17% of the population
 at some point during the lifetime of an individual. Despite the availability of a wide range
 of antidepressant drugs, 30% to 40% of patients with major depression fail to respond to
 first-line antidepressant (e.g., selective serotonin reuptake inhibitors (SSRIs)) treatment,
 despite adequate dosage, duration, and compliance. Thus there is a clear need to develop
 novel and improved therapeutics for major depression. Current pathophysiological theories
 regarding the neurobiology of depression include alterations in intracellular signaling
 cascades, and impairments of cellular plasticity and resilience. There is recent evidence
 suggesting that promoting growth factors such as brain derived neurotrophic factor (BDNF) may
 provide a mechanism for the treatment of depression. New information indicating modulation of
 glutamate receptors in the actions of antidepressant treatments suggests a novel approach to
 develop a new class of antidepressants. Studies have shown that the biarylpropylsulfonamide
 AMPA (2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl) propanoic acid) receptor potentiators
 (LY392098 and LY451616) have antidepressant effects in animal models of depression. Several
 studies have demonstrated that AMPA receptor activation can increase expression of BDNF both
 in vitro and in vivo. Thus, one possible new approach for the treatment of depression is to
 use an AMPA receptor potentiator.

 In this study we propose to compare the ampakine receptor potentiator Org 24448 to placebo
 for the treatment of Major Depression. Inpatients and outpatients (primarily outpatients),
 ages 21 to 70, with a diagnosis of Major Depression (without psychotic features), will be
 randomized to double-blind treatment to either Org 24448 or placebo for a period of 8 weeks.
 Acute efficacy will be determined by demonstrating a greater response rate using specified
 criteria. Approximately 90 patients with acute major depression will be enrolled in the study
 in order to reach the goal of randomizing 70 patients in the controlled trial.
INCLUSION CRITERIA:

 1. Male or female subjects, 21 to 70 years of age.

 2. Female subjects who are not of childbearing potential (i.e., surgically sterile,
 postmenopausal for at least one year) or must be using a medically accepted means of
 contraception. Women using oral contraceptive medication for birth control must also
 be using a barrier contraceptive. Women of childbearing potential must also have a
 negative serum Beta-HCG (human chorionic gonadotropin) at pre-study.

 3. Subjects must fulfill DSM-IV criteria for Major Depression (296.3) without psychotic
 features, based on clinical assessment and confirmed by a structured diagnostic
 interview, the Structured Clinical Interview for DSM-IV TR Axis I Disorders, SCID-P.

 4. Subjects have a history of at least one previous episode of depression prior to the
 current episode.

 5. Subjects must have an initial score of greater than or equal to 32 on the Inventory of
 Depressive Symptoms, Clinician version (IDS-C) at Visit 1 and Visit 2.

 6. Subjects must not have greater than a 25% decrease in the IDS-C total scores during
 washout (between Visits 1 and 2).

 7. Each subject must have a level of understanding sufficient to agree to all tests and
 examinations required by the protocol and must sign an informed consent document.

 8. Current major depressive episode of at least 4 weeks duration.

 9. Subjects who have not responded to adequate previous trials of at least one
 antidepressant as determined by the Antidepressant Treatment History Form (ATHF)
 criteria (score greater than or equal to 3). Additionally, patients who have not
 completed antidepressants trials of adequate dose and duration due to intolerance to
 therapy may be induced if they have demonstrated intolerance to greater than or equal
 to 3 antidepressant medications in the current or a previous episode, and did not meet
 ATHF criteria for a single adequate treatment trial in the current episode. 3
 intolerant trials would count as an adequate failed trial. If this criteria has not
 been met, the Principal Investigator may allow for a four-week prospective trial of a
 standard antidepressant (at the patients' and clinicians' discretion) for potential
 participants who have not responded to at least one adequate trial for the current
 episode per inclusion criteria.

 EXCLUSION CRITERIA:

 10. Presence of psychotic features or a diagnosis of Schizophrenia or any other psychotic
 disorder or bipolar disorder as defined in the Diagnostic and Statistical Manual,
 Version IV (DSM-IV).

 11. Subjects with a diagnosis of Obsessive Compulsive Disorder as defined in the DSM-IV.

 12. Subjects reporting Borderline or Antisocial Personality disorders. Other Axis II
 disorders do not qualify one for exclusion from the study.

 13. Subjects with a history of DSM-IV drug or alcohol dependency or abuse (except for
 nicotine or caffeine) within the preceding 3 months.

 14. Female subjects who are either pregnant or nursing.

 15. Serious, unstable illnesses including hepatic, renal, gastroenterologic, respiratory,
 cardiovascular (including ischemic heart disease), endocrinologic, neurologic,
 immunologic, or hematologic disease.

 16. Subjects with a history of neutropenia or medication-induced blood dyscrasia.

 17. Clinically significant abnormal findings of laboratory parameters, physical
 examination, EEG, or ECG.

 18. Subjects with a lifetime history of autism, mental retardation, pervasive
 developmental disorders, or Tourette's syndrome.

 19. Subjects with uncorrected hypothyroidism or hyperthyroidism.

 20. Subjects with one or more seizures without a clear and resolved etiology.

 21. Treatment with a reversible monoamine oxidase inhibitor (MAOI) within 2 weeks prior to
 Visit 2.

 22. Treatment with fluoxetine within 4 weeks prior to Visit 2.

 23. Treatment with clozapine or electroconvulsive therapy (ECT) within 3 months prior to
 study Visit 2.

 24. Judged clinically to be at serious suicidal or homicidal risk.

 25. Participation in a clinical trial of another investigational drug within 1 month prior
 to study entry (visit 1).

 26. Patients starting hormonal treatment (e.g., estrogen) in the last 3 months prior to
 visit 1.

 27. Patients undergoing current nonpharmacologic antidepressant treatments, such as light
 therapy and psychotherapy.

 28. Patients will be excluded who have previously failed greater than or equal to 3
 lifetime adequate antidepressant trials by ATHF criteria (Sackeim 2001).

 29. Patients with any evidence of a seizure disorder as assessed by an EEG with photic
 stimulation.

 ADDITIONAL INCLUSION AND EXCLUSION CRITERIA FOR PET SCANS ONLY: THIRTY SUBJECTS WITH MAJOR
 DEPRESSIVE DISORDER WILL PARTICIPATE IN THE IMAGING COMPONENT OF THIS STUDY.

 INCLUSION:

 1. Subjects who are ages 21-70.

 2. Subjects with an early age of onset (before age 40).

 3. Subjects who either meet melancholic subtype criteria and/or have a first degree
 relative with bipolar disorder.

 4. Negative pregnancy test within 24 hours of positron emission tomography (PET) in women
 of childbearing potential.

 EXCLUSION:

 1. Subjects will have been off psychotropic drugs (including zolpidem) for at least 3
 weeks (8 weeks for fluoxetine) prior to PET.

 2. Subjects with a history of lifetime DSM-IV substance dependence (except for nicotine
 or caffeine).

 3. Subjects with substance abuse within 12 months (except for nicotine or caffeine).

 4. Subjects with a current or lifetime history of hypertension or diabetes.

 5. Subjects who have reached the annual research radiation exposure limit.