Mineral and Bone Disorders Outcomes in Stage 5D of Chronic Kidney Disease
Mineral and Bone Disorders Outcomes in Stage 5D of Chronic Kidney Disease
The MBD-5D is a prospective observational study with a case-cohort and a cohort design.
 Eligible patients are receiving hemodialysis and have secondary hyperparathyroidism. The
 study's three goals are (1) to record the patients' characteristics, and variation in the
 patterns of their treatment; (2) to analyze factors associated with variation in those
 medical practice patterns; and (3) to identify practice patterns and other factors that
 affect hospitalization, mortality, and other patient-level outcomes.
The MBD-5D is a 3-year prospective observational study with a case-cohort and a cohort
 design. Eligible patients comprise all patients who are receiving hemodialysis at the
 participating facilities, and who also have secondary hyperparathyroidism(2HPT). The study
 has 3 goals: to record the characteristics of those patients and variation in the patterns of
 their treatment; to analyze factors associated with variation in those medical practice
 patterns; and to identify the practice patterns and other factors that affect
 hospitalization, mortality, and other patient-level outcomes. In the case-cohort study, the
 outcomes are relatively infrequent events (all-cause and cardiovascular mortality). The
 cohort study includes a randomly selected sample of 40% of all study participants; and the
 outcomes are hospitalization, parathyroid interventions, bone fracture, MBD management
 status, etc. Explanatory variables comprise medications and other factors likely to be
 associated with outcomes of dialysis and of 2HPT, and facility-level practice patterns.
Inclusion Criteria:

 -  patients receiving hemodialysis

 -  patients whose intact PTH concentration is at least 180 pg/mL (106 pg/mL for whole
 PTH) OR patients who are receiving intravenous active vitamin D sterols or oral active
 vitamin D sterols (falecalcitriol)

 Exclusion Criteria:

 -  patients have been undergoing hemodialysis for less than 3 months