Examining the Individual Response to a Restricted Sodium Diet in Hypertensive Patients
Examining the Individual Response to a Restricted Sodium Diet in Hypertensive Patients
Excessive dietary sodium intake is an independent risk factor for hypertension and
 cardiovascular disease. A vast array of efforts have tried to reduce sodium consumption based
 on evidence indicating a public health benefit. Yet this benefit has been questioned, mainly
 based on studies showing variability in individual responses to a sodium-restricted diet
 (SRD). The effects of an SRD on blood pressure vary, and adherence to an SRD is not optimal.
 The original Sodium Watchers Program (R01NR012967) was developed and implemented by Dr.
 Misook Chung (University of Kentucky). In this pilot study, the modified Sodium Watchers
 Program will propose improving adherence to an SRD through education and digital
 self-monitoring for daily sodium intake and blood pressure.

 In addition, few studies have examined individuals' metabolic responses to the SRD. In a
 secondary analysis, we further will examine genetic variants associated with salt sensitivity
 and whether such a genetic component is associated with sodium excretion and BP control.

 A total of 40 hypertensive patients will be randomly assigned to the intervention (n=20) or
 control group (n=20). The intervention group will receive 8-week education sessions remotely
 using a video conferencing program. All participants will collect a 24-hour urine specimen
 for sodium excretion and a total of 4.0ml of peripheral blood will be drawn for salt
 sensitivity during baseline visit. All participants will be asked to log their activities in
 real-time, including food intake and in-home BP monitoring using Fitbit and accompanied
 mobile app and BP monitor.
Inclusion Criteria:

 -  Systolic blood pressure of 120-159 mmHg or diastolic blood pressure of 80-99 mmHg,
 whether or not taking blood pressure medications.

 -  Smartphone with a data plan

 -  Valid email address

 -  Willing and able to participate in online study videoconferencing visits (Zoom)

 -  Reads and writes in English

 Exclusion Criteria:

 -  Participating in another related research study

 -  Cardiovascular disease event (e.g. stroke, myocardial infarction) in prior 6 months

 -  Active cancer

 -  Recent hospitalization due to psychiatric condition or event

 -  Pregnancy or breastfeeding - current or planned during the study period

 -  Documented dementia

 -  Prisoners

 -  Diabetes Diagnosis

 -  Heart Failure Diagnosis