Negative Pressure Wound Therapy -PREVENA in Prevention of Infections After Total Knee Arthroplasty (TKA)
Negative Pressure Wound Therapy -PREVENA in Prevention of Infections After Total Knee Arthroplasty (TKA)
This trial is a prospective, single center, unblinded, randomized, controlled study to assess
 the safety and efficacy of negative pressure wound therapy in preventing infections after TKA
 surgery . The study will enroll 316 patients that will undergo TKA. patients will be
 randomized to the treatment group and undergo the study intervention - (NPWT) The
 intervention will take place at the end of the surgery. The Patients that are randomized to
 the control group will receive standard treatment. Both groups will be assessed at two weeks
 and six weeks. period.
Inclusion Criteria:

 -  Ages: 18 to 80

 -  Males- not involved in active military duty.

 -  Females-non child bearing potential, or females of child-bearing potential who have a
 negative pregnancy test (hCG urine) within 72 hours of informed consent.

 Exclusion Criteria:

 -  Active systemic or local infection.

 -  History of malignancy, radiotherapy, or chemotherapy for malignancy (except BCC of the
 skin)

 -  Active autoimmune disease.

 -  Any past or present immunosuppressive treatment.

 -  Current treatment with chemotherapeutic agents

 -  History of metabolic bone disease (primary or secondary).

 -  Chronic renal insufficiency (defined by 50% increase of normal levels).