Dilantin Levels With Continuous Delivery of Enteral Feedings - A Pilot Study
Dilantin Levels With Continuous Delivery of Enteral Feedings - A Pilot Study
It is unclear how enteral nutrition via a feeding tube should be given when a patient is
 receiving enteral Dilantin. Some caregivers hold the feedings for one hour before and one
 hour after the Dilantin dose to insure adequate absorption of the medication and some
 caregivers think that the feedings do not need to be interrupted.

 Hypothesis: Dilantin levels will remain therapeutic when enteral nutrition is given
 continuously during the administration of enteral Dilantin.

 The objective of this study is to determine Dilantin levels when enteral feedings are given
 by the continuous method. Thirty patients will be studied. When Dilantin levels are in the
 therapeutic range for 2 consecutive days on interrupted feedings (baseline), the patient will
 be switched to continuous feedings uninterrupted for the medication, for 7 days. Dilantin
 levels will be checked daily and if the levels become subtherapeutic an intravenous (IV)
 bolus of Dilantin will be given and the enteral dose will be increased (doses determined by
 primary caregiver). Serum albumin will be measured at baseline and at the beginning and end
 of each week, in order to calculate free Dilantin.
Rationale: It is unclear how enteral nutrition via feeding tube should be given when a
 patient is receiving enteral Dilantin. Some caregivers hold the feedings for one hour before
 and one hour after the Dilantin dose to insure adequate absorption of the medication and some
 caregivers think that the feedings do not need to be interrupted. Both methods are used in
 this institution, although the interrupted method is recommended by the Clinical Nutrition
 Service. Interrupting the feedings has the obvious disadvantage that the patient receives
 less hours of feeding and requires more nursing intervention.

 Key Objectives: To determine the change in Dilantin levels when enteral feedings are given by
 the continuous method.

 Study Population: 30 patients already on Dilantin for seizure prophylaxis who are already
 receiving enteral nutrition by the interrupted method and have stable, therapeutic Dilantin
 levels.

 Major Inclusion Criteria:

 1. on Dilantin for seizure prophylaxis (dose determined by primary caregiver) with
 therapeutic Dilantin levels

 2. receiving enteral nutrition by the interrupted method at goal feeding rate;

 3. age >18

 4. feeding tube in proper position, no restriction as to type of feeding tube (nasogastric,
 nasoduodenal, gastrostomy, jejunostomy), but both Dilantin and enteral feeding must be
 given through the same tube.

 Major Exclusion Criteria:

 1. history of seizures

 2. albumin infusions necessary during study period

 3. anticipation that feedings will need to be held for more than 4 hours at a time

 4. Patients that do not maintain stable Dilantin levels (< 25% variability) with the
 interrupted method of feeding; 5) inability to obtain consent from patient or
 spokesperson.

 Allocation to Groups: all patients will be switched from baseline method of feeding
 (interrupted) to continuous feeding.

 Procedures: When Dilantin levels are in the therapeutic range for 2 consecutive days on
 interrupted feedings (baseline), the patient will be switched to continuous feedings
 uninterrupted for the medication, for 7 days. Dilantin levels will be checked daily and if
 the levels become subtherapeutic an IV bolus of Dilantin will be given and the enteral dose
 will be increased (doses determined by primary caregiver). Serum albumin will be measured at
 baseline and at the beginning and end of each week, in order to calculate free Dilantin.

 Risks and Discomforts:

 1. subtherapeutic Dilantin levels, but these will be closely followed;

 2. seizures, patient will be discontinued if this occurs;

 3. venipuncture for 10 Dilantin levels and 3 serum albumin determinations (minimum blood
 for each test is 0.4 cc).

 Confidentiality: Subjects will be identified only by initials and study number.
Inclusion Criteria:

 1. On Dilantin for seizure prophylaxis (dose determined by primary caregiver) with
 therapeutic Dilantin levels

 2. Receiving enteral nutrition by the interrupted method at goal feeding rate

 3. Age >18

 4. Feeding tube in proper position, no restriction as to type of feeding tube
 (nasogastric, nasoduodenal, gastrostomy, jejunostomy), but both Dilantin and enteral
 feeding must be given through the same tube

 Exclusion Criteria:

 1. History of seizures

 2. Albumin infusions necessary during study period

 3. Anticipation that feedings will need to be held for more than 4 hours at a time

 4. Patients that do not maintain stable Dilantin levels (< 25% variability) with the
 interrupted method of feeding

 5. Inability to obtain consent from patient or spokesperson