A Study on Diagnosis and Treatment of End Stage Liver Disease Complicated With Infection (SESLDIR Study)
A Study on Diagnosis and Treatment of End Stage Liver Disease Complicated With Infection (SESLDIR Study)
The term of End Stage of Liver Disease (ESLD) was raised in 80's of 20 Century, but without a
 restrict definition. Infections are the cause and effect in occurrence and development of
 ESLD, which not only induce or exacerbate ESLD, but also are the most combined complication.
 Multi-resistant bacteria, multi-organ injury, selection of anti-microbes, supporting
 treatment, disorder of intestine microbiota, et al are dilemma in clinical practice.
 Appropriate and formal diagnosis and treatment of ESLD combined infection are imperious
 nowadays.
Inclusion Criteria:

 Decompensation of liver cirrhosis:

 1. ALB <35 g / L; A / G <1.0

 2. TBIL> 35μmol / L;

 3. ALT> 1 × ULN and / or AST> 1 × ULN

 4. PTA <60%

 5. Ascites or hepatic encephalopathy or esophageal variceal bleeding

 Acute-on-chronic liver failure:

 1. Chronic liver disease based on: chronic hepatitis or decompensated cirrhosis

 2. onset time: <4 weeks

 3. Hepatic encephalopathy: with or without

 4. Coagulation: PTA ≤ 40% or INR ≥ 1.5

 5. Jaundice: TBIL ≥ 171μmol / L or daily increase ≥ 17.1μmol / L

 Chronic liver failure:

 1. The basis of chronic liver disease: decompensated cirrhosis

 2. onset time: -

 3. Hepatic encephalopathy: with or without

 4. Coagulation: PTA ≤ 40% or INR ≥ 1.5 Jaundice: significantly higher

 Exclusion Criteria:

 -