Effect of Olivomed (Olive Extract) on Endothelial, Cardiac and Vascular Function
Effect of Olivomed (Olive Extract) on Endothelial, Cardiac and Vascular Function
Olive extracts are considered to have antioxidant properties. The investigators will study
 the effect of olive extracts containing hydroxytyrosol on endothelial, cardiac and vascular
 function in patients with coronary artery disease .
30 patients with stable angiographically documented coronary artery disease will be
 randomized to receive olive extracts with high concentration of hydroxytyrosol (10 mg po
 twice per day included in Olivomed capsules) or placebo for three months and then they will
 be switched off to the alternate treatment (placebo or Olivomed capsules) for another 3
 months
Inclusion Criteria:

 1. Age <70 years

 2. Stable coronary heart disease

 3. Patients with acute coronary syndrome who have undergone percutaneous coronary
 intervention (PCI) or coronary artery bypass grafting (CABG), 2 months must have
 passed since the incident

 4. High LDL levels, low HDL, high triglycerides

 Exclusion Criteria:

 1. Age> 70 years

 2. Patient with diabetes

 3. Patient with hypertension

 4. Patient with liver disease

 5. Patient with thyroid disease

 6. Patient with active malignancy

 7. Patient with a disease that affects inflammatory markers (rheumatic diseases, etc.)

 8. Patient with chronic renal failure (creatinine> 2 mg / dl)

 9. Patient treated chronically with corticosteroids

 10. Patient who has joined a weight loss program or any dietary intervention or intensive
 exercise programme within the previous 2 months or consumes multivitamin preparations
 with antioxidant properties.