Treatment Of Bone Cyst With Bone Marrow Mesenchymal Cell Transplantation
Treatment Of Bone Cyst With Bone Marrow Mesenchymal Cell Transplantation
There are two types of bone cysts, unicameral and aneurismal. These cysts happen to anyone,
 but they are most commonly seen in children and young adults while their bones are still
 growing. Living with a bone cyst and determining treatment options depend on the type of
 cyst.

 Non-surgical treatments for unicameral bone cysts involves repeated X-rays in individuals who
 do not experience any symptoms.

 Surgical removal of a unicameral bone cyst is needed if it becomes especially painful, or the
 area of the bone starts to thin out. The investigators aim to assess the clinical efficacy
 and side effects of mesenchymal stem cells seeded on bone matrix in repairing bone cyst.
Bone cysts are benign lesions usually discovered in children from age of 5 to 15 years.
 Treatment options include observation, corticosteroid injection and surgery. Sometimes the
 risk of surgery is comparable to the likelihood of fracture without treatment. In orthopedic
 surgery, bone chips , various types of ceramics, natural and synthetized bone mineral
 hydroxyapatite and tricalcium phosphate, as well as numerous polymers and co-polymers of
 alfa-hydroxy acids are used to perform as an osteoconductive and rarely osteoinductive factor
 to help bone formation.Some evidence demonstrated that bone marrow mesenchymal stem cells
 deposited on the surface of this constructs enhance its osteogenic differentiation. In this
 study the investigators seeds cultured bone marrow derived mesenchymal stem cells on bone
 matrix, to evaluate its therapeutic potential in repairing unicameral or aneurysmal bone
 cyst.This composite is placed in the bone cyst after its curettage during a
 surgery.Post-operation assessment is done by X-Ray examination and MRI at 1, 2, 6, and 12
 months after treatment.
Inclusion Criteria:

 -  Bone cyst diagnosed with MRI, CT-scan, or X-Ray

 -  Intact cyst wall with high risk for fracture

 -  Cysts with minimum diameter of 6mm

 -  Diagnostic test performed on cyst fluid

 -  Provided written consent form

 Exclusion Criteria:

 -  Patients with diagnosis of cancer

 -  Patients enrolled in other clinical trial