Refining a Biobehavioral Intervention to Enhance Recovery Following Hematopoietic Stem Cell Transplantation
Refining a Biobehavioral Intervention to Enhance Recovery Following Hematopoietic Stem Cell Transplantation
The goal of this project is to refine and evaluate the feasibility of a brief, behavioral
 intervention to improve the recovery following hematopoietic stem cell transplantation
 (HSCT). Cancer patients who were treated with HSCT will learn behavioral techniques to
 improve sleep and increase daytime activity with the goal of alleviating insomnia, fatigue,
 and depression after HSCT. If the intervention is feasible and acceptable to patients, a
 future study will test the effects in a larger trial, with the long-term goal of improving
 the care and quality of life of cancer survivors recovering from HSCT.
Details of the assessment strategy:

 Patient-reported outcomes:

 Participants will complete self-report measures prior to HSCT and 9 (mid-intervention) and 18
 weeks (post-intervention) post-HSCT. The sleep disturbance, fatigue, and depression modules
 of the NIH Patient Reported Outcomes Measurement Information System (PROMIS) will be the
 primary outcomes. The investigators will compare performance with more established
 instruments the investigation team has previously used: Insomnia Severity Index (ISI),
 Fatigue Symptom Inventory (FSI), and the Inventory of Depression and Anxiety Symptoms (IDAS)
 depression subscale.

 Actigraphy:

 The Actiwatch-2 (Philips Respironics), a wrist-worn actigraphy device, will be used to
 objectively quantify circadian rest-activity patterns over a continuous 7-day period using
 1-minute sampling epochs at three time points: prior to HSCT and 9 (mid-intervention) and 18
 weeks (post-intervention) post-HSCT. The following indices will be calculated: mesor (mean
 activity level), amplitude (rhythm height), acrophase (time of day the rhythm peaks), and
 R-squared (robustness of the rhythm). Participants will complete a concurrent nightly sleep
 log, and traditional sleep parameters will be calculated from both the logs and actigraphy,
 including total sleep time (TST), sleep onset latency (SOL), wake time after sleep onset
 (WASO), and sleep efficiency (SE). For daytime activity, calibration thresholds will be used
 to aggregate activity data into steps and minutes spent in sedentary, light, moderate, and
 vigorous activity
Inclusion Criteria:

 -  Adults 18 years of age or older undergoing hematopoietic stem cell transplantation
 (HSCT) at the University of Wisconsin Carbone Cancer Center (UWCCC)

 -  Autologous transplant recipients with multiple myeloma or lymphoma (both Hodgkin's and
 Non-Hodgkin's types) receiving standard conditioning regimens

 -  Allogeneic transplant recipients undergoing fully ablative transplants

 -  Participants who develop treatment complications or disease recurrence after being
 enrolled in the study may continue to participate if they are able to do so

 Exclusion Criteria:

 -  Autologous transplant recipients receiving non-standard regimens

 -  Autologous transplant recipients with diagnoses other than multiple myeloma or
 lymphoma

 -  Allogeneic transplant recipients receiving reduced intensity regimens