Aggressive Fluid Hydration for the Prevention of Post-ERCP Pancreatitis
Aggressive Fluid Hydration for the Prevention of Post-ERCP Pancreatitis
Aggressive hydration with lactated Ringer's solution (LRS) has been shown in a preliminary
 research to reduce the incidence of post-endoscopic retrograde cholangiopancreatography
 (ERCP) pancreatitis. This randomized, controlled trial was designed to assess the effect of
 peri-procedural aggressive intravenous hydration with LRS on the incidence of post ERCP
 pancreatitis.
Patients underwent first-time ERCP were randomly assigned (1:1) to receive either LRS at a
 rate of 150 ml/hr starting 2 hours prior to procedure, and continued during and after
 procedure to complete 24 hours (aggressive hydration) or LRS at a rate calculated by the
 Holliday-Segar method given peri-procedurally as described earlier (standard hydration).
 Visual analog scale, serum amylase, lipase, C-reactive protein (CRP), and urine analysis were
 assessed prior to procedure and 24 hours after. The primary endpoint was post ERCP
 pancreatitis defined as new or increased epigastric pain persisting for ≥24 hours, elevation
 of amylase or lipase >3 times the upper limit of normal.
Inclusion Criteria:

 -  patients at age between 18-65 years old undergoing first time ERCP

 Exclusion Criteria:

 -  Ongoing acute pancreatitis

 -  Chronic pancreaittis

 -  Prior sphincterotomy

 -  Ongoing hypotension including those with sepsis

 -  Cardiac insufficiency (CI, >NYHA Class II heart failure)

 -  Renal insufficiency (RI, creatinine clearance <40mL/min)

 -  Severe liver dysfunction (albumin < 3mg/dL)

 -  Respiratory insufficiency (defined as oxygen saturation < 90%)

 -  Pregnancy

 -  Hyponatremia (Na+ levels < 130mEq/L))

 -  Hypernatremia (Na+ levels > 150mEq/L)