Real World Study of End-stage Liver Disease in China
Real World Study of End-stage Liver Disease in China
The aims of this study are exploring the current situation of end-stage liver disease in
 China, and the optimization of diagnosis and treatment. Liver cirrhosis often accompanied by
 a series of complications. Therefore, it is necessary to standardize the diagnosis and
 treatment of liver cirrhosis and its complications. End-stage liver disease mainly refers to
 the late stage of liver disease caused by various chronic liver damage. Its main feature is
 that liver function can not meet the physiological needs of human body. This study is a
 single-center, prospective and observational real-world study aimed at investigating and
 analyzing the current diagnosis and treatment of liver cirrhosis and end-stage liver disease
 in China.
The aims of this study are exploring the current situation of end-stage liver disease in
 China, and the optimization of diagnosis and treatment. Liver cirrhosis includes cirrhosis
 caused by hepatitis, alcoholic cirrhosis, non-alcoholic cirrhosis and schistosomiasis
 cirrhosis. Liver cirrhosis often accompanied by a series of complications, including portal
 hypertension and gastrointestinal bleeding, ascites and related infections, hepatorenal
 syndrome, hepatic encephalopathy, portal vein thrombosis, etc. Therefore, it is necessary to
 standardize the diagnosis and treatment of liver cirrhosis and its complications, but there
 are still disputes about most of the complications in various editions of the guidelines. In
 order to formulate the best empirical treatment plan, it is indispensable to master the
 epidemiological situation of cirrhosis in different places. However, there is a lack of
 support from large clinical data from China. End-stage liver disease mainly refers to the
 late stage of liver disease caused by various chronic liver damage. Its main feature is that
 liver function can not meet the physiological needs of human body. It covers the final stages
 of various chronic liver diseases, mainly manifested as severe impairment and decompensation
 of liver function, including chronic and acute liver failure, acute decompensation of
 cirrhosis, chronic liver failure and hepatocellular carcinoma. The concept of end-stage liver
 disease was first put forward in the 1980s and has not been strictly defined yet. However,
 due to the complications of end-stage liver disease, such as infection related to liver
 failure and portal hypertension, septic shock, hepatic encephalopathy, and serious decline in
 quality of life, and the one-year survival rate of most patients is less than 90%, it is
 necessary to put forward this concept. Therefore, there is still a need for large sample data
 to define end-stage liver disease and formulate evidence-based treatment plans.

 The aim of this study is to explore the efficacy, safety and economic benefits of different
 treatment options for patients with cirrhosis and complications and end-stage liver disease
 in the real world of China. To investigate the epidemiological rates of cirrhosis and
 end-stage liver disease, and to provide evidence-based medical evidence for the treatment and
 follow-up of cirrhosis and end-stage liver disease in China in the future.

 This study is a single-center, prospective and observational real-world study aimed at
 investigating and analyzing the current diagnosis and treatment of end-stage liver disease in
 China, exploring the situation of end-stage liver disease in China, exploring the treatment
 options for patients with end-stage liver disease that can effectively improve their
 prognosis, and seeking high-quality evidence-based medical treatment for cirrhosis and
 reducing the mortality of end-stage liver disease.
Inclusion Criteria:

 1. Informed consent of patients.

 2. Diagnosis of any of the following diseases: acute decompensation of cirrhosis, chronic
 and acute liver failure, chronic liver failure and hepatocellular carcinoma (stage
 III-IV)

 Exclusion Criteria:

 1. HIV antibody positive and AIDS patients

 2. Serious psychiatric history, especially depression. Severe mental illness is defined
 as major depression or psychosis, suicide attempts, hospitalization due to mental
 illness or a period of disability due to mental illness.

 3. Patients with serious diseases of heart, lung, kidney, brain, blood and other
 important organs.

 4. Patients with other malignant tumors (excluding those cured).

 5. Pregnant, lactating women or women of childbearing age who are ready to conceive.