Endothelial Function Study Before Cardiovascular Surgery
Endothelial Function Study Before Cardiovascular Surgery
The aim of this clinical trial is to evaluate the effect of chronic obstructive pulmonary
 disease (COPD) and/or obstructive sleep apnea syndrome (OSAS) on the endothelial function,
 before cardiovascular surgery, compared to non COPD non OSAS patients undergoing also a
 cardiovascular surgery, by an observational physiological study.

 An interim analysis will be performed when 100 patients will be included.
Secondary objectives of this clinical trial :

 -  To evaluate the effect of COPD and/or OSAS on the systemic inflammation,
 insulin-resistance and oxydative stress, in comparison with non COPD non OSAS patients.

 -  To evaluate the effect of COPD and/or OSAS on the inflammation and oxydative stress of
 the adipose tissue, in comparison with non COPD non OSAS patients.

 -  To validate the STOP-BANG questionnaire in patients undergoing a cardiovascular surgery
Inclusion Criteria:

 -  Men or women between 18 and 80 years old

 -  Patient with planned coronary artery bypass graft surgery

 -  Patient with planned peripheral vascular surgery

 -  Patient with aortic surgery

 Exclusion Criteria:

 -  Patient with aortic or mitral valvular replacement

 -  Patient with emergency peripheral valvular surgery

 -  Patient with emergency coronary artery bypass graft surgery

 -  Patient with evolutive malignancy disease

 -  Pregnant or lactating women

 -  Patient with inadvisable bronchodilator (used for functional respiratory) exploration