Effectiveness of Different Approaches for the Rehabilitation of Gait in Patients With Parkinson's Disease
Effectiveness of Different Approaches for the Rehabilitation of Gait in Patients With Parkinson's Disease
Evaluation of the effectiveness of three different approaches for the rehabilitation of gait
 in patients with PD within a multidisciplinary, intensive rehabilitation treatment (MIRT).
Gait disorders represent one of principal hallmark of Parkinson's disease (PD). Typically, PD
 patients demonstrate reduced stride length and walking speed during free ambulation, while
 double support duration and cadence rate are increased. Gait disorders are generally poorly
 responsive to dopaminergic treatments and are related to reduced quality of life and
 augmented risk of falls. Different rehabilitation techniques based on compensatory and
 learning strategies, which principally exploit the use of cues to bypass the defective basal
 ganglia and to ameliorate performance through practice, have been demonstrated to be
 effective in improving gait in patients with PD. Cueing techniques represent the central core
 for the rehabilitation of parkinsonian gait. In this context, it has been demonstrated that
 treadmill training can improve gait performance in PD patients. It probably acts as an
 external cue exerting a normalizing effect on the spatiotemporal gait parameters and leading
 to an enhanced gait rhythmicity and a reduced gait variability. The use of a treadmill with
 visual and auditory cues (treadmill-plus) seems to lead to a better improvement in gait
 parameters when compared to treadmill alone. Recently, the application of virtual reality
 (VR) has been introduced in the rehabilitation of PD. The use of VR is based on the
 interaction of the person with a virtual environment with the aim to promote motor learning
 through enhanced perceptions (visual, auditory, and haptic inputs).

 It has been widely demonstrated that a multidisciplinary, intensive, goal-based,
 motor-cognitive and aerobic treatment (MIRT), specifically designed for PD patients, provide
 parkinsonians with motor and functional benefits. Nevertheless, the contribution provided by
 treadmill, treadmill-plus and VR on gait parameters has not been previously addressed within
 MIRT.

 This study aims at investigating the superiority or the non-inferiority of these different
 devices in improving gait in PD patients in the context of MIRT.
Inclusion Criteria:

 -  Diagnosis of "probable" idiopathic Parkinson's disease according to Gelb et al (Gelb,
 1999);

 -  Mild to moderate stage of disease (stage 2-3) according to Hoehn & Yahr scale;

 -  Ability to walk on treadmill;

 -  Visual and hearing capacity sufficient to perceive the cues;

 -  No cognitive impairment (Mini-Mental State Examination score ≥ 26);

 -  Stable pharmacological treatment since 2 weeks before admission and during
 rehabilitation;

 Exclusion Criteria:

 -  Diagnosis of atypical or vascular Parkinsonism;

 -  Occurrence of cardiovascular, orthopaedic, peripheral nerves, musculoskeletal and
 vestibular disorders which could affect patient's locomotion or balance;

 -  Neuropsychiatric disturbances;

 -  Severe dyskinesia;

 -  Severe freezing of gait;