The βIG-H3 Protein: a New Marker in PANCreatic Adenocarcinoma (BIGHPANC)
The βIG-H3 Protein: a New Marker in PANCreatic Adenocarcinoma (BIGHPANC)
The primary objective of this trial is to evaluate the correlation between the intensity of
 the protein big-h3 expression at tumoural microenvironment and the TNM/UICC staging (from I
 to IV) of pancreatic adenocarcinoma lesion.
The pancreatic adenocarcinoma is the most common pancreatic cancer. Currently, it represents
 the fourth cause of death by cancer in France. The diagnosis is often realized when the
 disease is at an advanced stage because of its delayed clinical expression. Only 20% of the
 patients are diagnosed at a stage enabling a tumour resection.

 Scientists discovered a protein playing a key role: the βig-h3 protein. In mouse models, this
 protein is present in several stages of the tumorigenesis. A mutation of the gene Kras leads
 to the development of PANin (Pancreatic Intraepithelial Neoplasia) type precancerous lesions.
 The βig-h3 protein is early and highly expressed in the stroma around these lesions and in
 the pancreatic adenocarcinoma stroma. Moreover, studies showed that protein neutralization
 leads to a tumour size reduction by increasing the CD8+anti-tumor activity.

 This protein is detected in the blood serum of patients suffering from a pancreatic
 adenocarcinoma. So, this protein which is secreted by the extracellular matrix could be a
 predictive marker for the pancreatic adenocarcinoma.

 In this prospective, multicentric non-interventional study, it is anticipated to recruit 80
 patients (20 per TNM/UICC stage).

 Included patients will undergo two samples: A blood sample (5 ml) and a tumour sample
 (surgical exeresis piece or tumour tissue obtained for the initial diagnosis). In case of
 relapse, new samples will be performed.
Inclusion Criteria:

 -  Age ≥ 18 years at the day of consenting to the study

 -  Patient with a potential pancreatic adenocarcinoma whatever the TNM/UICC stage

 -  Systematic treatment not initiated

 -  Signed and dated informed consent document.

 Exclusion Criteria:

 -  Pregnant or breastfeeding woman

 -  Geographical, social or psychiatric reason preventing the patient from completing the
 study follow-up