Kisspeptin Influence on Glucose Homeostasis
Kisspeptin Influence on Glucose Homeostasis
This study examines how a naturally occurring peptide called kisspeptin might regulate blood
 sugar and insulin levels.
Inclusion/Exclusion Criteria:

 History:

 -  normal pubertal development

 -  stable weight for previous three months

 -  no active illicit drug use,

 -  no history of a medication reaction requiring emergency medical care,

 -  no difficulty with blood draws.

 Physical examination:

 • systolic BP < 140 mm Hg, diastolic < 90 mm Hg,

 Laboratory studies: (per MGH reference ranges)

 -  normal hemoglobin, unless hypogonadal then no lower than 0.5 gm/dL below the lower
 limit of the reference range for normal women (as men and women with hypogonadism have
 lower hemoglobin levels off of treatment)

 -  hemoglobin A1C < 6.5%

 -  BUN, creatinine not elevated

 -  AST, ALT < 3x upper limit of normal

 -  negative serum pregnancy test (for all women)

 -  no hyperlipidemia by fasting lipid panel

 Additional Criteria by Study Population

 Healthy Men:

 -  normal body mass index (BMI between 18.5-25)

 -  no history of chronic disease, except well controlled thyroid disease

 -  no recent use of prescription medications which interfere with metabolism or
 reproduction. Use of levothyroxine or seasonal allergy medications is acceptable.

 -  no history of diabetes in a first degree relative.

 Healthy Women:

 -  normal body mass index (BMI between 18.5-25)

 -  no history of chronic disease, except well controlled thyroid disease,

 -  no recent use of prescription medications which interfere with metabolism or
 reproduction. Use of levothyroxine or seasonal allergy medications is acceptable.

 -  no history of diabetes in a first degree relative,

 -  no use of contraceptive pills, patches or vaginal rings within last 4 weeks.

 -  regular menstrual cycles

 Postmenopausal Women:

 -  body mass index (BMI between 18.5-30)

 -  no history of chronic disease except thyroid disease, and osteoporosis,

 -  no recent use of prescription medications which interfere with metabolism or
 reproduction. Use of levothyroxine, osteoporosis medications or seasonal allergy
 medications is acceptable,

 -  no history of diabetes in a first degree relative,

 -  normal activate protein C resistance screen,

 -  if applicable, able to undergo appropriate washout from hormone therapy.

 Men and Women with Impaired Glucose Tolerance (IGT):

 -  diagnosis of impaired glucose tolerance by oral glucose tolerance test,

 -  all medical conditions well-controlled.

 Men and Women with Hypogonadism

 -  diagnosis of hypogonadism,

 -  all other medical conditions well-controlled,

 -  if applicable, able to undergo appropriate washout from hormone therapy.