Debulking and Chemotherapy With or Without Intraperitoneal Chemotherapy to Treat Peritoneal Carcinomatosis
Debulking and Chemotherapy With or Without Intraperitoneal Chemotherapy to Treat Peritoneal Carcinomatosis
This study will determine which of the two following treatment regimens provides greater
 benefit to patients with peritoneal carcinomatosis (gastrointestinal cancer that has spread
 throughout the abdomen):

 -  Surgical removal of tumors plus heated chemotherapy during surgery, followed by one dose
 of chemotherapy 7 to 12 days after surgery, followed 3 weeks later by 4 months of
 chemotherapy; or

 -  Surgical removal of tumors followed by 4 months of chemotherapy, starting 1 month after
 surgery.

 Patients 18 years of age and older with peritoneal carcinomatosis may be eligible for this
 study. Candidates are screened with a medical history, physical examination, and blood tests;
 chest X-ray and computed tomography (CT) scans; review of pathology slides; electrocardiogram
 (EKG), bone scan, and brain magnetic resonance imaging (MRI), as needed; and laparotomy.
 Laparatomy is a surgical procedure in which an incision is made in the abdomen to look at the
 amount and location of tumors in the abdominal cavity. Patients whose surgery reveals that
 the tumors cannot be removed are taken off study. Those eligible for the study have their
 tumors removed during this screening laparotomy as part of the study procedure, as follows:

 All participants undergo laparotomy and removal of as much tumor as possible, as described
 above. Patients are then randomly assigned to one of two treatment groups:

 -  Group 1 - During laparotomy, after tumor removal, patients receive continuous
 hyperthermic peritoneal perfusion (CHPP) with the anti-cancer drug cisplatin. For CHPP,
 the cisplatin solution is heated and delivered to the abdomen through a catheter
 (plastic tube), washed through the abdomen for 90 minutes, and then drained out of the
 body through another catheter. At the close of surgery, a small catheter, called a
 Tenckhoff catheter, is left in the abdomen and brought out through the skin. Between
 days 7 and 12 after surgery, one dose of fluorouracil and paclitaxel chemotherapy is
 delivered through this catheter. The catheter is removed following complete recovery
 from surgery and the patient is discharged from the hospital. Four to 6 weeks after the
 surgery, patients have CT scans of the chest, pelvis, and abdomen, and then begin
 intravenous (IV, through a vein) chemotherapy with oxaliplatin, 5-fluorouracil (5-FU),
 and leucovorin. The chemotherapy is given in 4-week courses as follows: oxaliplatin on
 day 1, infused over 2 hours through a vein in the arm or neck; leucovorin on days 1 and
 2, infused over 2 hours, followed by 5-fluorouracil over 22 hours; leucovorin and 5-FU
 repeated two weeks later on days 15 and 16. This regimen is repeated two weeks later.
 Between each week of chemotherapy is a week break. A course of chemotherapy consists of
 28 days (two weeks of chemotherapy and two 1-week breaks). Patients may receive up to
 four courses (total of 16 weeks) unless their disease progresses or they cannot tolerate
 further doses. Doses of the chemotherapy can be reduced if the side effects are too
 severe.

 -  Group 2 - Patients follow the same procedure as those in Group 1 for laparotomy, CT
 imaging, and IV chemotherapy with oxaliplatin, 5-fluorouracil, and leucovorin. They do
 not receive CHPP or chemotherapy into the abdomen.

 All patients undergo repeat imaging tests six weeks after surgery and at the conclusion of
 the intravenous (IV) chemotherapy. They return for a physical examination and CT scans every
 three months for the first year, every four months for the next two years, and then every six
 months for up to five years after treatment. They are also asked to complete quality of life
 questionnaires before and after surgery, at the completion of chemotherapy, and at every
 follow-up visit.
Patients with low-grade gastrointestinal adenocarcinoma and peritoneal carcinomatosis will
 undergo laparotomy and tumor debulking. Patients will be randomized at completion of tumor
 debulking to receive continuous hyperthermic peritoneal perfusion (HIPEC,formerly CHPP) with
 250 mg/m^2 cisplatin and an intraperitoneal dwell of 5-fluorouracil 800 mg/m^2 and paclitaxel
 125 mg/m^2 once between postoperative day 7 and 12. All patients will receive systemic
 oxaliplatin, leucovorin and infusional 5-FU, every other week of every four weeks starting 4
 to 6 weeks after operation and continuing for four cycles. The major endpoint is time to
 intraperitoneal tumor progression and survival in patients stratified based on history of
 previous treatment with systemic chemotherapy (yes vs. no), history of prior debulking
 surgery; and ability to optimally vs. suboptimally debulk intraperitoneal tumor burden.
-  INCLUSION CRITERIA:

 1. The patient must have histologically or cytologically proven peritoneal
 carcinomatosis from low-grade mucinous adenocarcinoma of the gastrointestinal
 tract. Patients with no tissue for examination may undergo percutaneous needle
 aspiration under computed tomography (CT) or ultrasound guidance as clinically
 indicated or a laparotomy with biopsy if a tumor grade cannot be determined on
 other available material.

 2. Radiologic workup must demonstrate that there is no imageable disease outside of
 the peritoneal cavity.

 3. Radiologic workup or prior abdominal exploration must show abnormalities
 consistent with disease which can be debulked to a residual size of less than 1
 cm in diameter per tumor deposit in the judgement of the investigators.

 4. Patients must have an Eastern Cooperative Oncology Group (ECOG) performance
 status of less than or equal to 2 on study entry and on the day prior to planned
 treatment.

 5. Patients must have a minimum expected duration of survival of greater than 16
 weeks.

 6. Patients must have recovered from any severe toxicity from all prior
 chemotherapy, immunotherapy or radiotherapy except as outlined in appendix 1 of
 the protocol and be at least 30 days past the date of their last treatment.

 7. Patients must have a serum aspartate aminotransferase (AST) and alanine
 aminotransferase (ALT) within 5 times the upper limit of normal and a total serum
 bilirubin of less than 3 times the upper limit of normal, both of which define
 the upper limit of grade 2 treatment related toxicities..

 8. Patients must have a absolute neutrophil count (ANC) greater than
 1,500/microliter.

 9. Patients must be age greater than or equal to 18 years.

 EXCLUSION CRITERIA:

 1. Patients will be excluded if they have concomitant medical problems that would place
 them at unacceptable risk for a major surgical procedure.

 1. Patients at increased risk for coronary artery disease or cardiac dysfunction
 (e.g. age greater than 65, and a history of hypertension, first degree relative
 with atherosclerotic coronary artery evaluation and will not be eligible if they
 demonstrate significant irreversible ischemia on a stress thallium study or an
 ejection fraction of less than 40%.

 2. Patients who have shortness of breath with minimal exertion or who are at risk
 for pulmonary disease (e.g., chronic smokers) will undergo pulmonary function
 testing and will not be eligible if their forced expiratory volume 1 (FEV1) is
 less than 1.2 liters or their maximum voluntary ventilation is less than 50% of
 expected.

 2. Patients who have a neurological toxicity of Grade 3 or greater will be excluded
 because of the potential neurotoxicity associated with platinum and paclitaxel
 therapy.

 3. Patients will be ineligible if they have a serum creatinine of greater than 1.5 mg/dL
 unless the measured creatinine clearance is greater than 60mL/min/1.73m^2.

 4. Patients will be ineligible if platelets are less than 75, 000/mm^3.

 5. Patients who have failed previous intraperitoneal chemotherapy will be ineligible.

 6. Pregnant women or women who are breast-feeding will be ineligible.

 7. Patients less than 30 kg will be ineligible.

 8. Patients who have undergone two or more operative procedures to debulk disease, have
 received 2 or more regimens of systemic chemotherapy, or any previous continuous
 hyperthermic peritoneal perfusion (CHPP) therapy will be excluded from study.