Differences of Small Airways Function Between Chronic Obstructive Pulmonary Disease(COPD) and Asthma-copd Overlap(ACO)
Differences of Small Airways Function Between Chronic Obstructive Pulmonary Disease(COPD) and Asthma-copd Overlap(ACO)
The purpose of this study is to research the differences of small airways function between
 subjects with diagnosis of chronic obstructive pulmonary disease(COPD) and asthma-COPD
 overlap(ACO).The assessment of quality of life is also carried out through questionnaires.
This is a randomized,open-label study to research the differences of small airways function
 between simple chronic obstructive pulmonary disease(COPD) and asthma-COPD
 overlap(ACO).Assessment of small airways is conducted at baseline,including forced expired
 volume in one second(FEV1),forced vital capacity(FVC),peak expiratory flow(PEF),maximum
 expiratory flow rate at 75% of vital capacity(MEF75),maximum expiratory flow rate at 50% of
 vital capacity(MEF50),maximum expiratory flow rate at 25% of vital capacity(MEF25),impulse
 oscillometry,diffusion function,residual volume(RV) and total lung
 capacity(TLC).Budesonide(160ug) and formoterol(4.5ug) bid will be given to both
 groups(chronic obstructive pulmonary disease and asthma-COPD overlap) for 3 months.Quality of
 life is assessed through questionnaires including modified Medical Research Council dyspnoea
 scale(mMRC),St George's Respiratory Questionnaire(SGRQ) and chronic obstructive pulmonary
 disease assessment test(CAT).All of the patients will have a follow-up visit after 3 months'
 treatment.
Inclusion Criteria:

 -  Male or female patients 18 to 80 years-old.

 -  A diagnosis of chronic obstructive pulmonary disease according to the Global
 Initiative for Chronic Obstructive Disease(GOLD 2018) guidelines are recruited to the
 chronic obstructive pulmonary disease group.A diagnosis of asthma-chronic obstructive
 pulmonary disease overlap according to Global Initiative for Chronic Obstructive
 Disease(GOLD 2018),Global Initiative for Asthma(GINA 2018) and Spanish COPD
 Guidelines(GesEPOC 2017) are recruited to the asthma-chronic obstructive pulmonary
 disease overlap group.

 -  Willing and able to provide written informed consent.

 -  Willing and able to attend all study visits and adhere to all study assessments and
 procedures.

 Exclusion Criteria:

 -  Severe comorbidities including unstable cardiac or pulmonary disease or any other
 medical conditions including unstable ischemic heart disease,unstable cardiac
 arrhythmia or heart failure,life threatening arrhythmias,etc.

 -  Recent history of chronic obstructive pulmonary disease exacerbation requiring
 hospitalization or need for increased treatments for chronic obstructive pulmonary
 disease within 6 weeks.