Tolerability/Safety and Efficacy of Inhaled AZD4818 in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
Tolerability/Safety and Efficacy of Inhaled AZD4818 in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
The purpose of this study is to see if treatment with AZD4818 for four weeks is tolerable,
 safe and effective in treating COPD and, if so, how it compares with placebo.
Inclusion Criteria:

 -  Clinical diagnosis of COPD, with symptoms for more than 1 year

 -  Current or ex-smokers with a smoking history of at least 10 pack-years (1 pack-year=20
 cigarettes/day for 1 year)

 -  Lung function (FEV1) 40 to 80% of the predicted normal value after using a short
 acting bronchodilator

 Exclusion Criteria:

 -  Clinical suspicion of active tuberculosis

 -  Any current clinically significant respiratory tract disorder other than COPD

 -  History of current clinically relevant arrhythmia, heart block, ECG abnormalities, or
 unstable angina