Ventriculo-arterial Coupling in Cirrhotics
Ventriculo-arterial Coupling in Cirrhotics
Cirrhotic in intensive care unit have a very specific haemodynamic status. Cardiovascular
 abnormalities in advanced liver cirrhosis are characterized by a hyperdynamic circulation
 featuring increased heart rate and high cardiac output, concomitant with decreased systemic
 vascular resistance. As liver cirrhosis progresses, cardiac dysfunction, known as cirrhotic
 cardiomyopathy, is associated with prognosis of these patients.

 Specifically, diastolic dysfunction has been more emphasized for estimating clinical outcome
 in cirrhotic patients, whereas systolic dysfunction has limited prognostic implications in
 hepatorenal syndrome patients.

 However, in most cirrhotic patients, cardiac dysfunction is latent and only manifests under
 stressful conditions because reduced ventricular contractility in these patients is masked by
 pronounced arterial vasodilation and increased arterial compliance. Therefore, a
 load-dependent index such as left ventricular ejection fraction is insensitive to detect
 systolic cardiac impairment in the resting state in cirrhotic patients. Hence, a more
 appropriate index is required to evaluate the integration of the ventricular and arterial
 systems in cirrhotic cardiovascular disorders.

 Interaction between the left ventricle and the arterial system has been explained on the
 basis of end-systolic pressure-volume relation. Left ventricular end-systolic elastance
 (Ees), as quantified by the ratio of end-systolic pressure to end-systolic volume, is an
 index of the load-independent ventricular contractile state. Given this pressure-volume
 relationship, effective arterial elastance (Ea) can be calculated by the ratio of
 end-systolic pressure to stroke volume, indicating a net measure of arterial load. The ratio
 of these values (Ea/Ees), designated ventriculo-arterial coupling (VAC), represents the
 integrated interaction of the ventricular and arterial systems.

 We can evaluate it with non-invasive echocardiographic method.

 We analyse VAC among cirrhotic patients admitted in intensive care unit, with non-invasive
 echographic method thanks to records made from August 2018 to April 2019.

 Hypothesis: VAC decrease from the baseline value when mean arterial pressure is improved.
Inclusion Criteria:

 -  Liver cirrhotic patients (any cause, any level)

 -  With acute decompensation

 -  Admitted in intensive care unit in Croix Rousse Hospital, Lyon, France

 -  Who receive NOREPINEPHRINE as hemodynamic therapy

 -  Blood pressure monitoring thanks to an arterial line (radial, humeral or femoral)

 -  Urinary catheter, suprapubic catheter or any comparable device to monitor urine
 output.

 -  The patient did not object to take part of the study.

 Exclusion Criteria:

 -  Acute hemorrhage (Clinical definition or hemoglobin lower than 70g/L at admission)

 -  Patient requiring kidney replacement therapy

 -  Patient requiring invasive mechanical ventilation

 -  Any pathology that makes non-invasive ventriculo arterial coupling assessment
 impossible (non-sinus rhythm, severe valvular disease)

 -  Patient who objects to take part of the study