Human Papilloma Virus DNA Self-Test
Human Papilloma Virus DNA Self-Test
HPV DNA testing by a clinician has been shown to be highly sensitive in detecting cervical
 disease. Can we prove that HPV self-testing will be sufficiently sensitive to detect disease
 in high risk population who for various reasons would not have routine pap smear screening?
Women between the ages of 18 years to post-menopausal with documented abnormal pap smear
 atypical squamous cells of undetermined significance and higher will be enrolled into the
 study. Patients will be taught how to collect vaginal samples with dacron swab and vaginal
 tampons by means of instructional video and manufacturer's instruction guide respectively.
 Physicians will perform pap smear and colposcopy. All samples will be sent to the University
 of Louisville lab for processing for HPV DNA detection by Hybrid capture 2 method.
Inclusion Criteria:

 Abnormal pap smear ASCUS or higher

 Age 18-postmenopausal

 Exclusion Criteria:

 Less than 18 years old

 Prior hysterectomy

 Pregnancy

 Use of corticosteroids

 HIV positive