Ketogenic Diet for Obesity Hypoventilation Syndrome
Ketogenic Diet for Obesity Hypoventilation Syndrome
Obesity hypoventilation syndrome (OHS) is a condition that occurs in small percentage of
 obese people that causes high carbon dioxide and low oxygen levels in the blood. OHS is
 associated with respiratory failure, pulmonary hypertension, and death. The cause of OHS is
 unclear. Since not all obese people develop OHS, it is believed that hormone imbalances can
 contribute to the breathing problem.

 Some diets can change the body's hormones. For example, low-carbohydrate, high fat
 "ketogenic" diets (KD) may decrease insulin and glucose levels and increase sensitivity to
 other hormones. The investigators hypothesize that a KD will improve breathing in OHS
 patients, even in the absence of weight loss.
Obesity hypoventilation syndrome (OHS) is a condition that occurs in small percentage of
 obese people, that leads to high carbon dioxide levels and low oxygen levels in the blood.
 OHS is associated with respiratory failure, pulmonary hypertension, hospital admissions, and
 death. Unfortunately, there is no treatment for OHS besides massive weight loss which often
 requires bariatric surgery.

 In this study, the investigators are examining whether switching from a regular diet to a
 ketogenic diet will improve breathing, oxygen, and carbon dioxide levels in OHS patients.
 After a few days-weeks on KD, hormone changes are known to occur and the investigators are
 examining whether these hormonal changes could stimulate breathing.

 This is a pilot study to examine the effects of a 12 day KD on OHS. The outcomes of the study
 include blood oxygen, carbon dioxide levels, plasma levels of hormones such as insulin,
 leptin, sleep studies, body composition a, weight, and metabolic rate.
Inclusion Criteria:

 -  Obesity (BMI≥30 kg/m2)

 -  Hypercapnia (PaCO2>45 or PvCO2>50) on blood gas, OR a sleep study with
 end-tidal/transcutaneous CO2 monitoring showing an awake CO2 level >50

 -  Participants without blood gas data may also have suspected OHS on the basis of serum
 bicarbonate >=28 mEq/L

 -  Lack of an alternative pulmonary diagnosis that adequately explains hypercapnia. Note
 that a documented pulmonary diagnosis (e.g. chronic obstructive pulmonary disease
 (COPD) or asthma) per se will not necessarily exclude subjects, since OHS is often
 misdiagnosed as obstructive lung disease. Functional or radiographic data must
 corroborate the presence of the alternate diagnosis.

 -  Subjects must have had a sleep study and clinical evaluation for sleep apnea. Most
 subjects with OHS are expected to have concomitant obstructive sleep apnea (OSA). This
 information is necessary to determine whether continuous positive airway pressure
 (CPAP)/noninvasive ventilation (NIV) will be used on the research sleep studies.

 Exclusion Criteria:

 -  Concomitant participation in another weight loss or diet program

 -  Patients with diabetes taking Sodium-glucose Cotransporter-2 (SGLT2) inhibitors (due
 to risk of diabetic ketoacidosis)

 -  Patients with type 1 diabetes

 -  Any patients with a history of diabetic ketoacidosis

 -  Patients with incomplete sleep apnea diagnosis or management (i.e. those still
 acclimating to CPAP, or pending therapeutic decisions about OSA management)

 -  Known or suspected abuse of narcotics or alcohol

 -  Liver cirrhosis

 -  Uncontrolled gout

 -  History of chronic renal insufficiency requiring dialysis

 -  Females who are pregnant, breast-feeding, or intending to become pregnant

 -  Food allergies or diet restrictions that research nutritionists cannot accommodate

 FOLLOW THIS LINK TO SEE IF YOU QUALIFY:

 https://mrprcbcw.hosts.jhmi.edu/redcap/surveys/?s=RYX7DELK9Y