Curcumin and Nanocurcumin in Oral Aphthous Ulcer
Curcumin and Nanocurcumin in Oral Aphthous Ulcer
Recurrent aphthous ulcer is a painful inflammatory lesion with a high prevalence. Since the
 etiology is not clear, several strategies have been proposed to reduce pain and severity of
 its symptoms. Today, curcumin is considered as an herbal medicine with anti-inflammatory
 properties. Treatment or control of various inflammatory diseases has been proposed, but its
 low solubility in water has reduced bioavailability, while the use of nanoparticle
 pharmaceutical techniques has been able to solve these problems. Therefore, the aim of the
 present study was to evaluate the clinical efficacy of a new topical curcumin gel with
 nano-technology and compare it with 2% curcumin gel in patients with recurrent aphthous
 ulcers.

 This randomized clinical trial was performed on 48 patients assigned to two groups
 (nano-curcumin gel) and (curcumin gel). Before treatment, the size of the wound and VAS were
 measured. After intervention, the two variables were measured again on the fourth and seventh
 days , then the amount of improvement was quantitatively and qualitatively compared in the
 two groups and a significant level of less than 0.05 was considered.
Inclusion Criteria:

 -  Patients with minor and recurrent aphthous ulcer lesions within 48 hours and Aphthous
 like Lesions

 Exclusion Criteria:

 -  Wounds are in inaccessible areas (such as posterior palate). If a person suffers from
 systemic disease (through questioning the patient) Patients with turmeric allergy and
 any type of gel used in this study. Pregnant or lactating women .. accompany with
 other mucosal lesions. Do not take any other medicine while taking intervention Major
 or herpeti form of aphthous ulcer