Chinese FPD Registry
Chinese FPD Registry
The purpose of the Chinese Familial Parkinson's disease Registry (CFPDR) is to develop a
 database of patients with familial Parkinson's disease (PD) in China.
Parkinson's disease (PD) is the second most common disorder among degenerative neurological
 disease. Familial PD (FPD) has its unique clinical feature and genetic basis. We aim to
 establish a database of FPD,and characterize the clinical feature, genetic basis,
 environmental factors and their interactions FPD in China.

 Method:

 1. Clinical feature will be measured by scales and neurological tests.Standard scales
 includes: Unified Parkinson's Disease Rating Scale(UPDRS), Hoehn-Yahr stages, NMSS,
 MMSE, PDSS(Parkinson disease sleep scales),Rapid Eye Movement Sleep Behaviour Disorder
 Questionnaire(RBDQ-HK),ESS(Epworth Sleepiness Scale),Rome III functional constipation
 scale，SCOPA-AUT (the Scale for Outcomes in PD for Autonomic Symptoms)，PFS(Parkinson
 Fatigue Scale)，CH-RLSq，Hyposmia rating scale(HRS)HAMILT depression scale，the 39-item
 Parkinson's Disease Questionnaire(PDQ-39)，Freezing of gait scale(FOG)，dyskinesia related
 scales, Wearing-off scale(WO)

 2. Peripheral blood from patients and other members in family will be collected for
 familial PD genetic testing.

 3. The environmental factors are exploded by questionnaires including smoking,drinking,
 pesticide and heavy metals.
Inclusion Criteria:

 -  Clinical diagnosis of Parkinson's disease, and either family history of Parkinson's
 disease (first or second degree family member affected by Parkinson's disease) AND/OR
 Clinical diagnosis of Parkinson's disease and their parents are close relatives(First
 or second degree family member of an Index Case, affected or unaffected by Parkinson's
 disease).

 Exclusion Criteria:

 -  Lack of capacity to consent to participate in the project