Taurine Supplementation and Training Effects on Energy Metabolism, Inflammation and Oxidative Stress in Obese Women
Taurine Supplementation and Training Effects on Energy Metabolism, Inflammation and Oxidative Stress in Obese Women
Taurine supplementation researches have increased due to its antioxidant and
 anti-inflammatory actions, and its ability to modulate lipid metabolism by stimulating the
 expression of proteins that regulates mitochondrial biogenesis and increases respiratory
 function (PGC-1α and PPAR) and irisin release when associated to exercise. Since obesity can
 induce metabolic disorders including abnormal production of adipokines and activation of
 pro-inflammatory signaling pathways also mitochondrial metabolism dysfunction in the adipose
 tissue, the use of taurine would be a new strategy for obesity prevention and treatment.
 Moreover, the association of taurine and exercise could improve exercise effects, promote
 higher energy expenditure and increase mitochondrial respiration, consequently resulting in
 weight loss. Therefore, the present investigation aims to evaluate the effects of the
 association of taurine supplementation and a combined exercise training protocol (aerobic and
 strength) on resting energy expenditure, weight, body composition, blood markers of
 inflammation and oxidative stress, telomeres length, and mitochondrial function and the
 expression of genes that regulates energy metabolism and lipid oxidation in the white adipose
 tissue in obese women.
A double-blind placebo-controlled study was conducted with 24 obese women (32.9±6.3 years).
 Capsules of taurine (3 grams) (GTau) or placebo (GP) were daily supplemented 2 hours before
 training. The training program was composed of aerobic and strength exercises during one
 hour, 3 times a week, for an 8-week period (intensity of 80% heart rate). The taurine
 supplemented group received only taurine capsules (3g/day) during 8 weeks. Measurement of
 weight, hip and waist circumference, and body composition (by Deuterium oxide) were performed
 before and after the intervention. Resting energy expenditure and nutrients oxidation were
 assessed by calorimetry.

 In order to check the effects of the intervention, abdominal tissue biopsy will be performed
 for white adipose tissue analysis, evaluation of mitochondrial function and quantification of
 the expression of genes related to energy metabolism and lipid oxidation and taurine pathway;
 blood collection will be done for quantification of taurine levels, inflammatory (IL-10,
 IL-15, IL-6, IL-1, TNF-α, and CRP), adipokines (adiponectin, adipsin, resistin, fetuin and
 leptin) and oxidative stress (GPx, SOD and MDA) markers. Also, evaluation of telomere length
 was performed. Body composition was evaluated by deuterium oxide method, weight, waist and
 hip circumference were accessed. All the measurements were performed before and after the
 intervention period.
Inclusion Criteria:

 -  Body Mass Index of 30 to 40 kg / m²

 -  Sedentary

 -  No associated co morbidity

 Exclusion Criteria:

 -  Women who have a medical impediment to the practice of physical exercise

 -  Women that have undergone bariatric surgery

 -  Menopause, cancer or any metabolic disease

 -  Smokers

 -  Alcoholics

 -  Insulin-dependent diabetes