Feasibility, Safety and Efficacy of Remote Ischemic Preconditioning for Symptomatic Intracranial Arterial Stenosis in Octogenarians
Feasibility, Safety and Efficacy of Remote Ischemic Preconditioning for Symptomatic Intracranial Arterial Stenosis in Octogenarians
Making a limb transiently ischemic induces ischemic tolerance in distant organs such as the
 heart. This study aims to evaluate the feasibility, safety and initial efficacy of using
 briefly repetitive bilateral limb ischemic preconditioning (BLIPC) to protect the brain in
 octogenarians with symptomatic intracranial arterial stenosis.
Inclusion Criteria:

 1. age between 80 to 95 years old

 2. Trial of Org 10172 in Acute Stroke Treatment-1 (TOAST-1) subtype

 3. National Institutes of Health Stroke Scale (NIHSS) score 0-15, and Modified Rankin
 Scale (mRS) score 0-4

 4. ABCD2 score between 6 to 7

 5. stable vital signs, normal hepatic and renal functions

 6. no hemorrhagic tendencies

 Exclusion Criteria:

 1. within 72 hrs of intra-artery or intravenous thrombolysis

 2. intracranial hemorrhage or large area of cerebral infarction (more than 1/3 middle
 cerebral artery perfusion territory)

 3. any soft tissue, orthopedic, or vascular injury, wounds or fractures in extremities
 which may pose a contraindication for application of the preconditioning cuffs

 4. acute myocardial infarction

 5. systolic blood pressure more than 200 mmHg after drug control

 6. peripheral blood vessel disease

 7. hematologic disease

 8. severe hepatic and renal dysfunction

 9. severe or unstable concomitant disease

 10. cannot tolerate BLIPC or without informed consent