Study of Motor Slowing in Parkinson's Disease by a Computerized Mental Chronometry Paradigm
Study of Motor Slowing in Parkinson's Disease by a Computerized Mental Chronometry Paradigm
Action slowing has been demonstrated in many diseases. Parkinson's disease (PD) and
 Huntington's disease (HD) are two neurodegenerative diseases affecting the basal ganglia,
 particularly the medial globus pallidus, and the clinical expression of these two diseases is
 characterized by a combination of motor and cognitive disorders, but with two opposing
 patterns of dysfunction. Action slowing has been demonstrated in both of these diseases and
 has been extensively studied in Parkinson's disease, suggesting a perceptive-cognitive
 origin. Far fewer studies have been conducted in Huntington's disease. However, all of these
 studies were performed with different methodologies in small cohorts and the value of the
 proposed study is to use a validated and standardized computerized mental chronometry
 paradigm, providing a better understanding of the mechanisms of action slowing in these two
 diseases and to more clearly define a disease-specific profile.
Inclusion Criteria:

 -  Agreeing to participate in the study

 -  French mother tongue

 -  MMSE > 20/30

 -  Specific to the MP and MH:

 -  Parkinson's disease:

 -  defined by the criteria of the UKPDSBB

 -  stage 1 , 2 or 3 Hoehn and Yahr (ON)

 -  age of onset of the disease known

 -  brain MRI performed during follow-up

 -  Huntington disease :

 -  genetically defined (CAG > 35)

 -  weaning neuroleptic ( Tercian® and Solian® : 2 days; Haldol® : 5 days ;
 Tiapridal® and Xenazine : 1 day ; Zyprexa® : 4 days)

 -  Early stage : Fahn and Shoulson I and II is a CFT score between 7 and 13

 Exclusion Criteria:

 -  Illiteracy, writing or reading difficulties

 -  Visual perceptual auditory deficit or preventing reading, drawing, writing or
 understanding instructions

 -  Visual hallucinations

 -  Significant history may sound on cognition (unbalanced thyroid dysfunction, ischemic
 heart disease or embolic unstabilized or symptomatic, progressive neoplasia, chronic
 alcoholism weaned or not)

 -  Current or previous neurological diseases other than MH or MP: ischemic cerebral
 vascular accident or bleeding, head injuries (loss of higher knowledge in 15 minutes),
 epilepsy requiring treatment.

 -  Psychiatric disorders depression unless treated (stable treatment for 1 month)

 -  Psychotropic treatment (except anxiolytic, antidepressant steady since 1 month)

 -  Inability to achieve an autonomous operation without technical assistance over a
 distance of 20 meters.

 -  Inability to stand without technical assistance for 30 seconds.