Interactive Stepping Exercise on Memory
Interactive Stepping Exercise on Memory
This is a randomized controlled trail. A total of 28 individuals with aMCI will be randomly
 assigned to either the ISE group or control group. The ISE intervention conducts three times
 a week for 16 weeks. Outcomes are measured at baseline and after intervention. The primary
 outcomes are the Chinese version verbal learning test (CVVLT), selective reminding test
 (SRT), and logic memory test (Wechsler Memory Scale). The secondary outcomes are Montreal
 Cognitive Assessment (MoCA) for cognitive function, and trail making test Part A & B (TMT-A &
 B), Stroop test, and 25-item Executive Interview (C-EXIT 25) for executive function.
Inclusion Criteria:

 -  Age≥50 years

 -  Complained of memory impairment

 -  Chinese Version Verbal Learning Test 10-minute delays ≤ 6 words

 -  MMSE score≥24 and CDR score=0.5

 -  Activities of daily living are intact

 -  DSM-IV criteria for the diagnosis of dementia is not met

 Exclusion Criteria:

 -  Any significant neurologic disease other than suspected incipient Alzheimer's disease

 -  Psychotic features, contraindication of exercise... which could lead to difficulty
 complying with the protocol