Interaction of Otolith Stimulation and Carotid Baroreflex in Humans
Interaction of Otolith Stimulation and Carotid Baroreflex in Humans
It is well documented that a few days stay in space induces a change in the vestibular-ocular
 reflex reflecting a reinterpretation of sensory inputs following the disappearance of
 gravity. If the change of eye reflexes actually the result of a reinterpretation of sensory
 input, the investigators should also expect to see an alteration of the
 vestibular-cardiovascular reflexes. The modification of these reflexes may modulate the
 carotid baroreflex and thus participate in the post-flight cardiovascular deconditioning.

 The first objective of this project is to study the carotid baroreflex under different supine
 (dorsal, ventral and lateral) inducing different otolith stimulation in normal-gravity.
Inclusion Criteria:

 -  Healthy volunteers, male and / or female aged 18-30 years

 -  subject affiliated to a social security scheme, agreeing to participate in the study
 and who provided informed consent.

 Exclusion Criteria:

 -  who participated in a clinical trial within less than the period of exclusion from
 this project

 -  with a past or present history of heart disease, vascular, neurological, respiratory,
 rheumatological, metabolic or otologic.

 -  pregnant women (dosage beta HCG)

 -  having taken any medication heart, vascular, neurological, respiratory,
 rheumatological, metabolic or might interfere on vestibular test results during the
 two years preceding the experiment.

 -  smoking or smoking more than 5 cigarettes / day, 1 cigarette / day or 1 pipe / day