Phase II Study of Proton Radiation Therapy for Neuroblastoma
Phase II Study of Proton Radiation Therapy for Neuroblastoma
This research study is evaluating a therapy called proton beam radiation therapy (PBRT) as a
 possible treatment for neuroblastoma.

 Neuroblastoma most commonly occurs in and around the adrenal glands, which are located at the
 top of the kidneys. However, it can also occur in other areas where groups of nerve cells
 exist, such as other areas of the abdomen, neck and near the spine.

 Conventional radiation therapy with photons is used as standard treatment for many patients
 with neuroblastic tumors. In this research study, the investigators are looking at another
 type of radiation called proton radiation which is known to spare surrounding tissues and
 organs from unnecessary radiation. Proton radiation delivers radiation to the area requiring
 radiation. This may reduce side effects that patients would normally experience with standard
 radiation therapy or other means of delivering proton radiation therapy.

 In this research study, the investigators are evaluating the effectiveness of using proton
 radiation delivered to reduce side effects associated with radiation treatment. The
 investigators will also be assessing the late side effects experienced by participants in
 each treatment group.
Proton radiation will be delivered daily for 3-4 weeks, depending on the dose prescribed by
 study doctor. Treatment is delivered (Monday - Friday) for 5 days (no weekends or holidays).
 Each treatment the participant will lie on a table for 30-45 minutes.

 The radiation therapy will be outpatient at Massachusetts General Hospital.

 During radiation therapy, the participant will have the following weekly assessments and
 procedures:

 -  Physical Exam

 -  Assess for any side effects

 -  Routine blood tests (weekly or at least every other week)

 Post-treatment Follow Up Visit (s):

 The participant will be asked to return to the clinic 3-6 months after their last dose of
 radiation therapy and then annually for up to 5 years for the following procedures:

 -  Medical History

 -  Physical Exam

 -  Diagnostic Imaging

 -  Assess for side effects

 -  Lung Function Tests (if required)

 -  MUGA or ECHO (if required)
Inclusion Criteria:

 -  Participants must have histologically confirmed neuroblastoma or ganglioneuroblastoma
 or elevated urinary catecholamine metabolites. If tumor tissue was obtained,
 pathological review of surgical specimen at the Massachusetts General Hospital or
 other DF/HCC institution is required, but preliminary report only required prior to
 enrollment. If no tumor tissue was obtained, urinary catecholamine metabolites are
 required.

 -  Participants do not need to have measurable disease at the time of radiation. Age ≥ 3
 and ≤ 25 years at the time of diagnosis because this study evaluates this disease
 entity in the pediatric population which may differ from the adult population.

 -  Life expectancy of greater than 12 months.

 -  ECOG performance status ≤2 (Karnofsky ≥60%, Lansky ≥60%, see Appendix A).

 -  Diagnostic Imaging MRI and/or CT of the area to be treated within 8 weeks of any
 treatment. Baseline bone marrow biopsy and bone scan (with 99mTc-diphosphonate or MIBG
 scan (131I-MIBG or 123I-MIBG) from time of original diagnosis is required.

 -  Because radiation is known to be teratogenic, women of child-bearing potential and men
 must agree to use adequate contraception (hormonal or barrier method of birth control;
 abstinence) prior to study entry and for the duration of study participation. Should a
 woman become pregnant or suspect she is pregnant while participating in this study,
 she should inform her treating physician immediately.

 -  Ability of the patient or the patient's legal guardian to understand and the
 willingness to sign a written informed consent document.

 -  Participants or their legal guardian must sign consent prior to the initiation of
 radiation therapy.

 Exclusion Criteria:

 -  Patients will be ineligible if any prior therapeutic radiation therapy > 500 cGy has
 been delivered.

 -  Patients will be ineligible if chemotherapy was completed ≥ 1 year from the planned
 start date of radiation therapy or if the patient is referred for radiation therapy
 after a relapse following a regimen with chemotherapy alone.

 -  Individuals with a history of a different malignancy are ineligible except for the
 following circumstances. Individuals with a history of other malignancies are eligible
 if they have been disease-free for at least 5 years and are deemed by the investigator
 to be at low risk for recurrence of that malignancy. Individuals with the following
 cancers are eligible if diagnosed and treated within the past 5 years: cervical cancer
 in situ, and basal cell or squamous cell carcinoma of the skin.

 -  Pregnant females are excluded. Women of childbearing age/menstruating must have a
 negative pregnancy test prior to initiation of radiation therapy.