Positive Expiratory Pressure for the Treatment of Acute Asthma in Children
Positive Expiratory Pressure for the Treatment of Acute Asthma in Children
Asthma is a leading cause of emergency department (ED) visits for children. A novel way of
 treating asthma is the use of positive expiratory pressure (PEP). Positive expiratory
 pressure works by creating pressure in the lungs to keep airways open and to clear mucus from
 the lungs. PEP is already used in the treatment of asthma at the investigators institution,
 but studies evaluating the efficacy of PEP therapy in asthma exacerbations do not exist. This
 study plans to learn more about the use of PEP therapy in the treatment of asthma
 exacerbations in children in the emergency department. Specifically, the study aims to
 evaluate if PEP therapy reduces the severity of asthma exacerbations in children and if it
 reduces the need for additional therapies and admission to the hospital. This study will be a
 randomized control trial comparing children who receive standard therapy to those who receive
 standard therapy plus PEP therapy in the treatment of asthma exacerbations. Children age 2 to
 18 years presenting to the ED with moderate to severe asthma exacerbations will be included
 in the study. Reduction in clinical asthma severity will be measured by change in the
 Pulmonary Asthma Score (the respiratory severity score used at the investigators
 institution). The need for additional therapies and hospitalization will also be evaluated.
Inclusion Criteria:

 -  Age >= 2 and < 18 years of age

 -  Established diagnosis of asthma, defined as at least two prior episodes of treatment
 with bronchodilators in their lifetime

 -  Initial ED presentation with a moderate to severe asthma exacerbation, as defined by a
 pulmonary asthma score (PAS) >7

 -  PAS score >7 and <12 after completion of first line therapies (three doses
 albuterol/ipratropium bromide and oral corticosteroids)

 Exclusion Criteria:

 -  Do not receive complete first line therapies

 -  Immediately receive a disposition (admission or discharge) as determined by the
 treating clinician after completion of first line therapies

 -  Receive prednisone or more than two doses of inhaled bronchodilators prior to main ED
 evaluation (e.g. during EMS transport or primary care visit)

 -  Co-morbid illnesses interfering with or contraindicated to usual asthma therapy (e.g.
 facial or airway abnormalities, pneumonia, chronic lung disease, congenital heart
 disease, cystic fibrosis, or pneumothorax)

 -  Critically ill at presentation

 -  Pregnant women (women known to be pregnant at the time of enrollment)