Effect of Different Doses of Tomato Lycopene on Blood Pressure in Pre-hypertensive Otherwise Healthy Subjects
Effect of Different Doses of Tomato Lycopene on Blood Pressure in Pre-hypertensive Otherwise Healthy Subjects
Effect of different doses of tomato extract (contain Lyc-o-Mato 6% Oleoresin which Contain:
 5, 15 mg lycopene , in addition to Beta-carotene (0.15%), phytoene, and phytofluene (1%); and
 vitamin E (2%), phospholipids (15%), and phytosterols (0.6%) suspended in tomato oleoresin
 oil) compared with synthetic lycopene on blood pressure and plasma lycopene levels in never
 treated pre-hypertensive otherwise healthy subjects.
Inclusion Criteria:

 -  Aged 35-60,

 -  No antihypertensive treatment in the past or present,

 -  135< SBP< 145 or 85<DBP<95,

 -  Informed consent signed,

 Exclusion Criteria:

 -  Unwilling to participate in the study,

 -  Treated essential,

 -  secondary or complicated hypertension,

 -  SBP lower than 135 or higher than 145 mmHg,

 -  DBP lower than 85 or higher than 95 mmHg,

 -  Use of other medications (statins, NSAI ect..),

 -  Known allergy to tomato, carotenoids, or vitamin E,

 -  Diabetes Mellitus,

 -  Obesity BMI>32,

 -  Significant dyslipidemia,

 -  Patients with ischemic pain, S/P MI, PTCA or CABG, LVH or CHF,

 -  Smoker,

 -  Valvular heart disease,

 -  PVD,

 -  Cerebrovascular disease, s/p CVA, TIA,

 -  Any kind of kidney disease (creatinine>1.6),

 -  Chronic liver disease(elevated AST and ALT at least by 2 times of the normal range),

 -  Alcohol abuse,

 -  History of GI disease or surgery,

 -  History of malignancy in the past 5 years,

 -  History of autoimmune disease,

 -  Participation in other researches protocol