A Study to Investigate the Safety, Tolerability and Pharmacokinetics of Single and Repeat Doses of RV1729 for up to 28 Days
A Study to Investigate the Safety, Tolerability and Pharmacokinetics of Single and Repeat Doses of RV1729 for up to 28 Days
RV1729 is a new medicine being developed for the potential treatment of asthma and smoking
 related lung disease (also known as chronic obstructive pulmonary disease - COPD).

 The objective of this study is to investigate the safety, tolerability and pharmacokinetics
 of single doses of RV1729 and repeat doses of RV1729 for up to 28 days.
Inclusion Criteria:

 -  Be a man or woman between 18 to 60 years of age, inclusive, at the time of signing the
 informed consent.

 -  Cohorts 1, 2 & 3 women of childbearing potential must have a documented menstrual
 period prior to the first dose and be willing to use 2 forms of appropriate methods of
 contraception from screening until 4 months after the final dose of RV1729, OR

 -  Women of non-childbearing potential must be spontaneously amenorrhoeic for at least 1
 year or have been permanently sterilised, OR

 -  If a man, must be willing and able to use one of the contraception methods listed in
 the protocol and agree not to donate sperm from screening until 4 months after the
 final dose of RV1729

 -  Women must agree not to donate eggs (ova, oocytes) from screening until at least 6
 months after the final dose of RV1729

 -  Sign an informed consent document indicating they understand the purpose of and
 procedures required for the study and are willing to participate in the study.

 -  Body mass index between 19 and 30 kg/m2 and body weight not less than 50 kg.

 -  Vital sign assessments within normal ranges

 -  Have a 12-lead ECG recording consistent with normal cardiac function

 -  Capable of complying with all study restrictions and procedures including ability to
 use the study inhaler correctly

 Cohorts 1, 2 & 4 (healthy volunteers only)

 -  Healthy as determined by a physician, based on a full medical evaluation including
 medical history, physical examination and laboratory tests.

 -  Pre-bronchodilator spirometry readings (FEV1 and FVC) to be ≥80% predicted value and
 FEV1/FVC ratio >0.7

 -  Not taking prescription medications for 14 days prior to screening and agree not to
 use prescription medications throughout the duration of the study (with the exception
 of the use of contraceptives or hormone replacement therapy).

 -  Not taking over-the-counter medications and herbal medication for 14 days prior to
 screening throughout the study.

 Cohort 3 (asthma patients only)

 -  Documented history of asthma, at least 6 months prior to screening and currently being
 treated with daily inhaled corticosteroids with or without long acting beta-agonist
 (LABA)

 -  Have a diagnosis of asthma. This will be confirmed by bronchodilator reversibility at
 screening

 -  Have a pre-bronchodilator FEV1 ≥60% and ≤85% of predicted normal value

 -  Have stable asthma based with no exacerbation requiring change in therapy for 12 weeks
 and no hospitalisation or visit to accident and emergency for asthma in the 12 months
 prior to screening.

 -  Not have a clinical abnormality or laboratory parameters outside the reference range.

 -  Not taking prescription medications for 14 days prior to screening and agree not to
 use prescription medications throughout the duration of the study except for use of
 contraceptives or hormone replacement therapy and treatment for asthma

 -  Not taking over-the-counter medications and herbal medication for 14 days, or
 antihistamines for 7 days prior to the screening visit and agree to refrain from
 taking such medications throughout the study.

 Exclusion Criteria:

 -  Upper or lower respiratory tract infection within 4 weeks before screening

 -  Clinically significant abnormal values for haematology, clinical chemistry or
 urinalysis at screening or Day -1

 -  Has a history of or current signs or symptoms of severe, progressive, or uncontrolled
 renal, hepatic, hematological, gastrointestinal, endocrine, pulmonary, cardiac,
 neurologic, cerebral, or psychiatric disease.

 -  History of, or a reason to believe a subject has a history of drug or alcohol abuse
 within the past 5 years.

 -  Positive test for alcohol or drugs of abuse, including cannabinoids, alcohol, opiates,
 cocaine, amphetamines, benzodiazepines or barbiturates at screening or on Day -1

 -  History of clinically significant allergies that, in the opinion of the Investigator
 or Medical Monitor, would contraindicate their participation.

 -  Subjects known to suffer from hayfever, or other allergy, that may require
 antihistamine therapy during the course of the study.

 -  Known allergy to the study drug or any of the excipients of the formulation or has
 previously been exposed to RV1729.

 -  Donated blood or blood products or had substantial loss of blood (more than 500 mL)
 within 3 months or intention to donate blood or blood products during the study.

 -  Received an experimental drug or used an experimental medical device within 3 months
 or within a period less than 10 times the drug's half-life, whichever is longer,
 before the first dose of the study drug is scheduled.

 -  If a woman has a positive serum pregnancy test at screening or a positive urine
 pregnancy test on Day -1, is pregnant, breast-feeding or planning to become pregnant
 during the study.

 -  Liver function test results >1.5 x ULN (upper limit of normal) at Screening or on Day
 -1.

 -  Positive test for human immunodeficiency virus (HIV) 1 and 2 antibodies, hepatitis B
 virus (HBV) infection or hepatitis C antibodies.

 -  History of smoking or use of nicotine-containing substances within the previous 6
 months, or a positive carbon monoxide test at screening or on Day -1 (or a smoking
 history ≥ 10 pack years).

 -  Preplanned surgery or procedures that would interfere with the conduct of the study.

 -  Employee of the Investigator or study centre, with direct involvement in the proposed
 study or other studies under the direction of that Investigator or study centre, as
 well as family members of the employees or the Investigator.

 -  Current or chronic history of liver disease, or known hepatic or biliary abnormalities
 (with the exception of Gilbert's syndrome or asymptomatic gallstones).

 -  History of regular alcohol consumption within 6 months of the study.

 -  The subject is unable or unwilling to comply fully with the study protocol.

 -  Subject is mentally or legally incapacitated.

 -  Unable or unwilling to undergo multiple venepuncture procedures or the subject has
 poor access to veins suitable for cannulation.

 -  Any other reason that the Investigator considers makes the subject unsuitable to
 participate.

 Cohorts 1, 2 & 4 (healthy volunteers only)

 -  Any chronic illness or clinically relevant abnormality identified on the screening
 medical assessment, laboratory tests or ECG

 Cohort 3 (asthma patients only)

 -  Administration of oral, injectable or dermal steroids or leukotriene modifiers within
 3 months or intranasal steroids within 1 week of the screening visit.

 -  Has ever had an episode of life-threatening asthma defined as respiratory arrest,
 intubation for asthma, or intensive care unit admission for asthma.

 -  Any acute or chronic illness or clinically relevant abnormality other than asthma
 identified on the screening medical assessment, laboratory tests or ECG.

 -  Has severe asthma based on Investigator assessment and/or use of prohibited asthma
 medications.

 Cohort 4 (healthy volunteers only)

 -  Women of child bearing potential