Prognostic Value of Cardiac and Renal Markers in Ischemic Stroke and Transient Ischemic Attack
Prognostic Value of Cardiac and Renal Markers in Ischemic Stroke and Transient Ischemic Attack
Patients with stroke or transient ischemic attack (TIA) are at high risk of poor outcome,
 recurrence of cardiovascular events or vascular death.Until now, no reliable predictive
 biological marker could be identified in the acute phase of stroke.We hypothese that, in the
 acute phase of ischemic stroke or TIA, the increase of cardiac ( brain natriuretic peptide,
 BNP) or renal markers (albuminuria, cystatin C)might predict recurrence of cardiovascular
 events or vascular death. We want to assess which one of these markers has the best prognosis
 value , in a prospective study of 300 stroke patients followed during 3 years.
Patients with ischemic stroke or TIA will be included in the 48 hours following the onset of
 symptoms, in 3 university hospitals.For each patient will be collected

 -  1 blood sample for the BNP measure in pg/ml

 -  1 blood sample for the Cystatin C measure in mg/l

 -  2 urinary samples to measure the albumine/creatinine ratio, at inclusion and 5 days
 after the inclusion, and to study the variation of albuminuria in micrograms/min.

 The clinical follow-up will be organized during 3 years. The following events will be
 notified: poor outcome (defined with the Barthel and Rankin scores), recurrence of
 cardiovascular or cerebrovascular events, vascular death.

 After adjustment on the main clinical prognosis factors, we want to determine wich one of
 these markers has the best prognosis significance and allows to identify in the acute phase
 the "high-risk" patients, in order to intensify individual treatment and secondary
 prevention.
Inclusion Criteria:

 -  Ischemic stroke or TIA in the first 48 hours following the onset of symptoms

 Exclusion Criteria:

 -  Patient unable to give an informed consent

 -  Urinary sample impossible to collect