Effect of Soy Intake on Cardiovascular Disease Biomarkers in Subclinical Hypothyroid Participants
Effect of Soy Intake on Cardiovascular Disease Biomarkers in Subclinical Hypothyroid Participants
The purpose of this study is to help the researchers understand if using a soy supplement
 impacts cardiovascular disease risk factors in patients with subclinical hypothyroidism.
This pilot trial is a double blind, randomized, parallel arm trial. Eighty participants with
 subclinical hypothyroidism will be randomized to consume either soy protein isolate or milk
 protein isolate for 8 weeks.
Inclusion Criteria:

 -  Patients with subclinical hypothyroidism (otherwise healthy volunteers)

 -  Adults aged 25 - 70 yrs.

 -  Willing to avoid consumption of soy/other isoflavone containing foods (i.e. some snack
 bars) during the study.

 -  Willing to avoid consumption of dietary (other than multivitamin) and herbal
 supplements during the study.

 Exclusion Criteria:

 -  Taking drugs that interfere with thyroid function

 -  Planning pregnancy in the next 6 months

 -  Taking drugs that lower lipids, blood pressure, or sensitize insulin

 -  Regular consumption of soy products (>20 g/wk)

 -  Consumption of soyfoods within 90 days prior to enrollment.

 -  Known history of soy or milk allergy or intolerance.

 -  Taking antibiotics during the intervention

 -  Active viral infections such as Human immunodeficiency virus (HIV) positive or
 hepatitis