Efficacy and Safety of Floseal for the Haemostasis During Laparoscopic Cholecystectomy in Acute Cholecystitis (GLA)
Efficacy and Safety of Floseal for the Haemostasis During Laparoscopic Cholecystectomy in Acute Cholecystitis (GLA)
The aim of this study is to evaluate the effect and safety of Floseal in this preliminary
 prospective trial with patients undergoing acute laparoscopic cholecystectomy for acute
 cholecystitis
Inclusion Criteria:

 -  Patients aged 18 - 65

 -  Clinical (pain, fever > 37.5 °C, WBC > 10.000 / microL), and ultrasound evidence of
 cholecystitis

 -  Surgical indication for laparoscopic cholecystectomy

 -  ASA class I-III

 -  Informed consent

 -  <72 hours from onset of symptoms

 Exclusion Criteria:

 -  Informed consent refusal

 -  Choledocholithiasis

 -  Pre surgical generalized peritonitis (clinical evaluation)

 -  ASA class > III

 -  Peripheral artery disease

 -  Active or past history of malignant systemic disease

 -  Pregnant or lactating females

 -  Known allergy to components Floseal including bovine allergy (bovine gelatin)

 -  Known drug or alcohol abuse

 -  Patients with known diabetes, chronic renal disease and other metabolic diseases

 -  Patients in chronic cortisone treatment more than 2 years before surgery

 -  Patients on chronic use of platelet inhibitors such as Aspirin, Plavix, NSAID's etc.