Correlation of Platelets Count With Endoscopic Findings in a Cohort of Egyptian Patients With Liver Cirrhosis
Correlation of Platelets Count With Endoscopic Findings in a Cohort of Egyptian Patients With Liver Cirrhosis
Portal hypertension is a common complication of liver cirrhosis that can lead to development
 of esophageal varices (EV). They are abnormally dilated veins within the wall of the
 esophagus that lead to haemorrhage (1). Majority of patients with cirrhosis will develop EV
 at some point, and about third of these patients will have at least one bleeding episode
 because of rupture of a varix . For this reason, screening endoscopy for detection of the
 presence of EV should be part of the diagnostic work-up in patients with cirrhosis. This is a
 very important preventive step for identification of those patients with variceal bleeding
 risk and furthermore, identification of patients in urgent need for prophylactic treatment.

 All guidelines stress on screening endoscopy for early detection of EV in cirrhotic patients
 with portal hypertension. However this approach is limited by its invasiveness and cost
 effectiveness issues of screening endoscopy .
Recent research has focused on the use of noninvasive methods to detect patients with the
 intention of avoiding endoscopy in low-risk cases . Thrombocytopenia (platelet count <
 150,000/μl) is a common complication in patients of chronic liver disease (CLD) . So, the
 investigators in this research formulated this study to determine whether platelet count can
 predict the presence of EV or varices which need prophylactic therapy (medium or large size
 EV) in a cohort of Egyptian patients with liver cirrhosis and can identify patients with the
 intention of avoiding endoscopy in low-risk cases.
Inclusion Criteria:

 -  Diagnosis of cirrhosis based on history, physical examination, laboratory tests,
 ultrasound scans and liver biopsy in some occasion.

 Exclusion Criteria:

 -  Hepatocellular carcinoma.

 -  Portal vein thrombosis.

 -  Parenteral drug addiction.