Exploration of Anticoagulation Program in Cerebral Aneurysm and Arteriovenous Malformations With Hybrid Operation 1
Exploration of Anticoagulation Program in Cerebral Aneurysm and Arteriovenous Malformations With Hybrid Operation 1
In the stage of registration study, our purpose is to find out the safety range of activated
 coagulation time level in cerebral aneurysm and arteriovenous malformations with hybrid
 operation.
This study is divided into anticoagulation program in cerebral aneurysm with hybrid operation
 and anticoagulation program in cerebral arteriovenous malformations with hybrid operation two
 parts, and each part divide into two stage, on the stage of registration study. This study is
 a multi-center, single-blind, prospective cohort study. Record the patient's intraoperative
 activated coagulation time Changes in detail, to observe the effect of activated coagulation
 time maintenance level on hemorrhage event rate of Intraoperative and postoperative 48 hours,
 purpose to find out the safety range of activated coagulation time level in cerebral aneurysm
 and arteriovenous malformations with hybrid operation. On the stage of randomized controlled
 study. This study is a multicenter, single-blind, prospective, randomized controlled study.
 Patients is divided into intraoperative standard dose group of Heparin Sodium and low dose
 group of Heparin Sodium randomly. To observe the effect of different anticoagulation regimens
 on activated coagulation time safety coverage rate during surgery, and finally develop a
 scientific and effective intraoperative anticoagulant therapy program.
Inclusion Criteria:

 1.All patients undergoing hybird surgery.

 Exclusion Criteria:

 1. Poor general condition , severe primary disease, surgical contraindications

 2. Patient or family refused surgery

 3. Fusiform aneurysm,Traumatic aneurysm,Infectious aneurysms

 4. Combined with other hemorrhagic cerebrovascular disease

 5. Combined with malignant brain tumor

 6. Perinatal, Pregnancy

 7. Patients unwilling to participate in the trial