Assessment of Quadriceps Muscle Electrostimulation Used in Patients Suffering From Cystic Fibrosis
Assessment of Quadriceps Muscle Electrostimulation Used in Patients Suffering From Cystic Fibrosis
This is an add-on, randomized, open label, clinical trial that evaluates the use of
 quadriceps electrostimulation as an additional retraining procedure in patients suffering
 from cystic fibrosis.
Cystic fibrosis is an autosomal recessive genetic disease due to a mutation of the CFTR
 protein gene. The CFTR protein transports chloride ions (Cl-) across cell membranes in the
 lungs, pancreas, digestive tract, reproductive tract, and skin.

 CFTR mutation mainly leads to a dysfunction of the pulmonary system and pancreas exocrine
 function.

 Several studies showed that cystic fibrosis commonly induces a reduction of effort tolerance,
 peripheral muscular strength and work capacity.

 Patients suffering from cystic fibrosis with a high endurance capacity have a lower risk of
 poor prognosis. Those with a severe dyspnea have a higher benefit with a force training or a
 combined force and endurance training than with endurance training alone.

 We propose to study the effect of a quadriceps electrostimulation program, performed prior to
 an endurance retraining program using a cycloergometer, in patients with cystic fibrosis
 associated with severe pulmonary dysfunction, to enhance their muscular performance and
 increase their adherence to the cycloergometer retraining program.

 This is a randomized trial with two groups:

 Group A: experimental group, twenty patients. Six weeks with electrostimulation program
 followed by six weeks under a cycloergometer program.

 Group B: control group, twenty patients. Six weeks with their usual physical activity
 followed by six weeks with a cycloergometer program.

 The Randomization is stratified on expiratory volume per second. The size of randomization
 blocks is random because of the open design.
Inclusion Criteria:

 -  Age >= 18 years

 -  Patient suffering from cystic fibrosis

 -  Patient has at least three measures of maximum expiratory volume per second <= 45% of
 the theory among the 6 last measures performed

 -  Affiliation to French social security

 -  Capacity to consent

 Exclusion Criteria:

 -  Pregnant women

 -  Contraindication to application of magnetic field

 -  Pacemaker

 -  History of neurosurgical intervention

 -  Presence of metallic particles near the stimulation site.