Vitamin D Levels in Stage IV Colorectal Cancer Patients
Vitamin D Levels in Stage IV Colorectal Cancer Patients
The purpose of this study is to find out what effects, good and/or bad, vitamin D blood
 levels has on stage IV colorectal cancer. Tbe doctors want to see if it is possible to
 increase low vitamin D levels into normal range using vitamin D supplements taken by mouth.
 Low vitamin D levels have been associated with worse outcomes in persons who have cancer. Low
 vitamin D may also cause people to have symptoms such as pain and fatigue. We want to see if
 increasing low vitamin D levels will help improve cancer outcomes. Vitamin D is routinely
 repleted in all subjects known to be vitamin D deficient. Therefore, the treatment given
 would be considered standard of care.
Inclusion Criteria:

 -  Patients with Stage IV (metastatic) colorectal cancer

 -  Baseline 25-hydroxy vitamin D level < 30 ng/ml

 -  Age ≥18 years of age

 Exclusion Criteria:

 -  Current or previous malignancy except adequately treated non-melanoma skin cancer,
 curatively treated in-situ cancer of the cervix, or other solid tumors curatively
 treated with no evidence of disease for > 3 years

 -  Albumin < 3.2

 -  Patients on concurrent chronic steroids, other than those allowed for routine
 antiemetics, or inhaled steroids

 -  Patients receiving phenobarbital, phenytoin, orlistat and cholestyramine

 -  Hypercalcemia (Calcium >10.5 mg/dl)

 -  Calcium x Phosphorus > 70 mg2/dL2