Observation Study of Clinical Manifestation and Outcome in Chinese Patients With Pulmonary Vasculitis
Observation Study of Clinical Manifestation and Outcome in Chinese Patients With Pulmonary Vasculitis
The purpose of this study is to observe the clinical manifestation, Lab findings including
 chest CT scans, pathological findings and outcomes in chinese patients with pulminary
 vasculitis.
Presentation of patient with suspected vasculitis

 1. Established diagnosis Clinical findings Laboratory workup Tissue biopsy Angiogram where
 appropriate

 2. Evaluating respiratory system Chest HRCT Pulmonary function test Bronchoscopy exam(BALF,
 TBB) Lung biopsy(needle biopsy, VAST)

 3. screening underlying damage to other system Paranasal sinus, vision & audition Nervous
 system Kidney Gastrointestinal tract Heart & vessel Skin Hematology Muscle, bone & joint

 4. Treatment

 5. Prognosis

 Evaluation

 1. Study visits occurred at baseline; at weeks 4; and at 2, 4, 6,12,18,24,30 months.

 2. Disease activity was measured on the basis of the BVAS/WG and the physician's global
 assessment.

 3. Damage related to disease or treatment was scored according to the Vasculitis Damage
 Index (scores for this index range from 0 to 64, with higher scores in- dicating more
 severe damage).

 4. Health related quality of life was scored with the use of the Med- ical Outcomes Study
 36-Item Short-Form Health Survey (SF-36).Scores on this scale range from 0 to 100, with
 higher scores indicating better health.

 5. Serial serum samples were tested for proteinase 3-ANCA and myeloperoxidase-ANCA by means
 of a direct enzyme-linked immunosorbent assay (ELISA).
Inclusion Criteria:

 -  Males and Females

 -  Aged from 18-75 years with informed consent

 -  Patients with ANCA-vasculitis

 1. Wegener's granulomatosis, microscopic polyangiitis or CSS

 2. positive serum assays for proteinase 3-ANCA or myeloperoxidase-ANCA

 3. manifestations of activity disease, and Birmingham Vasculitis Activity Score for
 Wegener's Granulomatosis (BVAS/WG) of 3 or more (scores range from 0 to 63, with
 higher scores indicating more active disease)

 Exclusion Criteria:

 -  Females planning to bear a child recently or with childbearing potential

 -  Secondary vasculitis, cancer,infective disease or drug induced vasculitis