Calcium and Phosphorus Whole-Body Balance and Kinetics in Patients With Moderate Chronic Kidney Disease
Calcium and Phosphorus Whole-Body Balance and Kinetics in Patients With Moderate Chronic Kidney Disease
This pilot study aims to develop a method for simultaneous whole-body calcium and phosphorus
 balance and full kinetic modeling of both ions in patients with chronic kidney disease.
Inclusion Criteria:

 -  Men or women, ages 30-75 years old, any race or ethnicity

 -  Moderate chronic kidney disease

 -  Female subjects must be postmenopausal (>12 months since last menstrual period),
 surgically sterile, or confirmed not pregnant by pregnancy test

 -  Must be on stable doses of medications (except those noted in exclusion criteria) for
 at least 4 weeks prior to the study

 -  Willing to discontinue nutritional supplements (e.g. vitamin D, calcium,
 multivitamin/minerals, or others) upon enrollment until completion of the study

 -  Adequate vitamin D status defined as serum 25D > 20 ng/mL

 Exclusion Criteria:

 -  Plans to initiate dialysis within 6 months

 -  Hypercalcemia defined as serum calcium >10.5 mg/dL within past 3 months

 -  Hyperkalemia defined as serum potassium >5.5 mg/dL within past 3 months

 -  Hyperphosphatemia defined as serum phosphate >5.5 mg/dL within past 3 months

 -  Intestinal disease that alters absorption or normal intestinal function including
 celiac disease, small bowel resection, or bariatric surgery

 -  Serious, uncontrolled underlying systemic disease including diabetes, lupus,
 hypertension

 -  Pregnant or breastfeeding

 -  Prescribed a phosphate binder medication, calcitriol, vitamin D analogs,
 calcimimetics, parathyroid hormone analogues, and other medications that may alter Ca
 and P metabolism within past 30 days