Effect of Renexin Tablet in Patients With Recurrent Vestibulopathy
Effect of Renexin Tablet in Patients With Recurrent Vestibulopathy
The purpose of this study is to determine whether Renexin is effective in the treatment of
 vestibular symptoms in patients with recurrent vestibulopathy.
1. Study design

 -  Among patients who visitied for recurrent vertigo more than 3 months, patients will
 be included after ruling out other peripheral vertigo through history taking,
 physical examination, Dix-Hallpike test, head-thrust test.

 -  Included patients will go through permission, laboratory tests (CBC, chemical
 battery, coagulation battery, urine HCG (only women of childbearing age),
 posturography. During patients selection period for inclusion(2 weeks), taking
 medication for vertigo is prohibited.

 -  Included patients will be randomized to Treatment group (Renexin) and Placebo
 group.

 -  All patients before treatment will do dizziness handicap inventory(DHI), visual
 analogue scale (VAS) for vertigo, questionnaire for quality of life (SF36).

 -  After 4 weeks(+-~ 3 days) of drug administration, DHI, VAS for vertigo, SF36 will
 be done for drug compliance and side effects.

 -  After 8 weeks(+-~ 3 days) of drug administration, posturography, DHI, VAS for
 vertigo, SF36 will be done for drug compliance and side effects.

 -  For control of severe vertigo during drug administration, Valium 2mg can be used as
 a salvage treatment, and number of valium administration will be checked at every
 visit.

 2. Statistical analysis

 -  As a statistical analysis, paired T-test will be used to compare equilibrium score,
 DHI, VAS, SF-36. When p-value is <0.05, it will be considered as significant
 difference.
Inclusion Criteria:

 -  Recurrent vestibulopathy patient with symptoms more than 3 months of recurrent vertigo

 -  Visual analogue scale (VAS) score between 4 to 8

 Exclusion Criteria:

 -  Showing signs of central lesion in MRI or neurologic exams

 -  central nystagmus or loss of consciousness with vertigo

 -  cerebellar symptoms such as ataxia, dysarthria, gait disturbance

 -  Diagnosed as peripheral vertigo such as benign paroxysmal positional vertigo,
 Meniere's disease, migrainous vertigo in recent 3 months

 -  Bilateral vestibular dysfunction

 -  Vestibular neuronitis symptom appeared in recent 6 months

 -  Chronic liver disease (ALT>100 or AST>100) or chronic kidney disease (Creatinine > 3.0
 mg)

 -  Blood Hemoglobin < 10mg/dl (in male) or < 8 mg/dl (in female)

 -  Contraindication for testing drug (ex. Pregnancy or breast feeding etc.)

 -  Taking antiepileptics such as phenobarbital, phenytoin, carbamazepine or rifampin in
 recent 2 weeks

 -  Taking cilostazol, gingko biloba for other disease

 -  Allergy/hypersensitivity to Renexin

 -  Severe drug toxicity when taking Renexin previously