Effect of TU-100 in Patients With Irritable Bowel Syndrome (IBS)
Effect of TU-100 in Patients With Irritable Bowel Syndrome (IBS)
The purpose of this study is to compare the effects of 5g of Daikenchuto (TU-100) three times
 per day (Daikenchuto [TU-100] is a botanical agent that modulates gastrointestinal nerves),
 and placebo on rectal sensation (sensation ratings of urgency to defecate and sensation
 threshold for pain) in response to rectal balloon distension by barostat in patients with
 IBS.
Inclusion Criteria:

 1. Meet Rome III criteria for IBS.

 2. Willing and able to provide written informed consent.

 3. If a female of childbearing potential, must be using an acceptable form of
 contraception during the study and for 30 days after the last dose. Acceptable methods
 include surgical sterilization, hormonal contraceptives (such as oral contraceptives,
 Depo-Provera, NuvaRing), condoms used with a spermicide, an IUD [Intrauterine device]
 or abstinence.

 Females are not considered to be of childbearing potential if they are postmenopausal
 for at least 2 years or have been surgically sterilized.

 4. Aged 18 to 65 years, inclusive.

 5. Have a body mass index (BMI) between 18 and 40 kg/m2, inclusive.

 6. Have a negative urine drug screening at Visit 1.

 7. Have normal or not clinically significant laboratory results as reviewed by the study
 physicians.

 8. Have a normal rectal examination result on file within the past 2 years or performed
 at Visit 1 in order to exclude the possibility of an evacuation disorder (examination
 must exclude findings suggestive of an evacuation disorder such as high sphincter tone
 at rest, failure of perineal descent and spasm, tenderness or paradoxical contraction
 of the puborectalis muscles).

 9. Agree to avoid alcohol during the entire study to avoid corrupting the data from the
 rectal barostat tests.

 Exclusion Criteria:

 1. Have a structural or metabolic diseases or conditions that affect the GI system.

 2. Be taking any medication that in the opinion of the principal investigator has a
 potential to alter GI transit (this includes but is not limited to osmotic or
 stimulant laxatives, magnesium or aluminum-containing antacids, prokinetics,
 erythromycin, gabapentin, pregabalin, narcotics, anticholinergics, antidepressants
 [including selective norepinephrine reuptake inhibitors], antipsychotics, opiates,
 GABAergic agents and benzodiazepines).

 Note: Tricyclic antidepressants are permissible at doses equal to or less than 25 mg
 daily; selective serotonin reuptake inhibitor antidepressants are permissible at low,
 stable doses. Analgesics such as Tylenol, ibuprofen, naproxen and aspirin are not
 permissible during Visits 2 and 3 to avoid corrupting data from the rectal barostat
 tests. All medications will be reviewed by the principal investigator on a case by
 case basis.

 Rescue medications: Rescue medications will be reviewed and approved as necessary for
 exacerbation of constipation or diarrhea since the study medication treatment period
 is about 14 days total. The patient will contact the study staff to request review and
 approval of the use of a rescue medication by the principal investigator. The use of
 the rescue medication will be documented by the patient in the bowel pattern, bloating
 and pain diary. Rescue medications are not allowed within 7 days of the rectal
 sensation studies to ensure data integrity.

 3. Have clinical evidence, including but not limited to, of a clinically significant
 abnormal physical examination or laboratory value or of a past event documented in the
 past medical record, or current clinically significant abnormal physical examination
 or laboratory value that could indicate significant cardiovascular, respiratory,
 renal, hepatic, GI, hematological, neurological, psychiatric or other diseases that
 interfere with the objectives of the study. If a laboratory test value falls outside
 of the reference range and is considered clinically significant, it may be repeated
 once at the discretion of the principal investigator. If the laboratory test result
 remains abnormal and clinically significant, the patient will be discontinued from the
 study and referred to a primary care physician for evaluation.

 4. Be a known substance abuser or be considered to be an alcoholic not in remission.

 5. Have participated in another clinical study in the past 30 days.

 6. Have a history of allergic reactions to egg, ginseng, ginger or Sichuan pepper.

 7. Be clinically lactose intolerant.