Type 2 Diabetes and the Effect of Probiotics
Type 2 Diabetes and the Effect of Probiotics
Insulin-resistance in type 2 diabetes is associated with chronic inflammation.
 Anti-inflammatory actions might increase sensitivity to insulin. Since some probiotics have
 anti-inflammatory properties, ingestion of the probiotic bacteria Lactobacillus Acidophilus
 NCFM might increase insulin-sensitivity.

 The inflammatory response to endotoxin injection and the insulin-sensitivity is examined
 before and after four weeks ingestion of probiotics.
Numerous studies have shown an association between insulin-resistance in type 2 diabetes and
 chronic low-grade inflammation. Some probiotics have an anti-inflammatory properties.
 Ingestion of probiotics might therefore, due to this property, increase sensitivity to
 insulin.

 In this study type 2 diabetics (N=24) and healthy control (N=24) are given the probiotic
 bacteria Lactobacillus Acidophilus NCFM for four weeks. The anti-inflammatory effect is
 examined by evaluating the inflammatory response (White blood cell count, plasma-cytokines)
 to an iv injection of endotoxin (0,3 ng/kg) before and after the intervention. Also the
 insulin-sensitivity is measured with an hyperinsulinemic euglycemic clamp before and after L.
 acidophilus NCFM.
Inclusion Criteria:

 -  Healthy

 -  Type 2 diabetes

 Exclusion Criteria:

 -  Heart failure

 -  Lung disease

 -  Infections in the last two weeks before endotoxin injections.

 -  Treatment with antibiotics