Urinary Tract Infection in Pregnancy
Urinary Tract Infection in Pregnancy
-  to describe the profile of uropathogenic E coli from Egyptian pregnant women with UTIs
 and a symptomatic bacteriuria.

 -  to determine the susceptibility pattern of our local isolated UPEC strains which is
 essential for optimal management of UTI.

 -  to evaluate the different virulence genes in UPEC isolates and their association with
 antibiotic resistance.

 -  to track common UPEC serogroups.

 -  to investigate the biofilm formation and the relationship between virulence genes and
 biofilm formation in UPEC strains isolated from patients.
Urinary tract infection represents the most common bacterial infection in pregnancy and the
 third common cause of human infection after respiratory and intestinal infections. The
 infection can be life threatening and associated with serious complications. UTI can be
 associated with defined symptoms'symptomatic' or without symptoms 'asymptomatic'.
 Asymptomatic bacteriuria is defined as the presence of >100000 colony forming units/ml of
 urine of a single pathogen in two consecutive midstream clean catch urine specimen or on
 catheterization specimen from an individual without signs or symptoms associated with urinary
 or genital organs. Asymptomatic bacteriuria can lead to acute pyelonephritis in30%of pregnant
 women and complications such as early delivery, increase risk of hypertension, pre-eclampsia,
 low birth weight and postpartum endometritis. Ecoli accounts for most cases of symptomatic
 and asymptomatic bacteriuria in women, representing70 _90 %of the cases. The important
 virulence factors of uropathogenic ecoli can be broadly divided into two groups :bacterial
 cell surface factors and secreted factors. The emergence of drug resistant microorganism
 among Uropathogenic Escherichia coli strains increases the serious threat to global health.
 Ecoli often acquired genes coding for antibiotic resistance, beta-lactamase enzymes are the
 most frequent and play a key role, conferring resistance of bacteria to beta lactam
 antibiotic group such as penicillin and cephalosporins. Therefore, knowledge regarding local
 prevalence of uropathogenic ecoli and antimicrobial resistance is essential for optimal
 management of UTI.
Inclusion Criteria:

 -  pregnant women who diagnosed through clinical examination and urine analysis. 3 groups
 : group 1 pregnant women with cystitis Group 2 pregnant women with Pyelonephritis
 Group 3 pregnant women with asymptomatic bacteriuria

 Exclusion Criteria:

 -  pregnant women on antibiotics _Patients with any anatomical abnormalities in the
 urinary tract