Community Awareness, Resources and Education (CARE II) Project: Project 1
Community Awareness, Resources and Education (CARE II) Project: Project 1
The study hypothesis is that the increased incidence of cervical cancer observed in
 Appalachian women over their non-Appalachian counterparts is due in part to inherited and
 somatic alterations of key components of the Transforming Growth Factor β (TGFβ) signaling
 pathway.
This project is a case control study that is designed to determine prevalence of inherited
 polymorphic and somatically acquired variants of key TGF-ß pathway components in a large
 cohort of Appalachian invasive cervical cancer (ICC) patients compared to healthy Appalachian
 women. It will be determined whether these genetic alterations contribute individually or in
 combination with other known environmental (Human Papillomavirus, Epstein-Barr Virus),
 behavioral (smoking), and social (stress, social networks) risk factors, to the increased
 susceptibility of Appalachian women to ICC development. Women will be recruited from several
 clinics and physician practices in West Virginia, Charleston and Appalachia Ohio and
 Kentucky. Participants will be women residing in these area who are 18 years and older, not
 pregnant, speak English, not cognitively impaired and able to provide informed consent. There
 will be three distinct types of women recruited into the study; 1. ARM 1 - previously treated
 for invasive cervical cancer; 2. ARM 2 - newly diagnosed with invasive cervical cancer; and
 3. healthy controls - without a diagnosis of cervical cancer.
Inclusion Criteria:

 -  18 years and older

 -  Patients previously or newly diagnosed with invasive cervical cancer

 -  healthy women without a diagnosis of any type of cancer

 -  English speaking

 -  Able to provide informed consent, biological and questionnaire data.

 Exclusion Criteria:

 -  Pregnant women