Assessment of Hand-grip in the Prevention of Postural Orthostatic Hypotension
Assessment of Hand-grip in the Prevention of Postural Orthostatic Hypotension
The study is aimed to assess the efficacy of hand-grip in preventing orthostatic hypotension
 in 20 patients diagnosed with autonomic failure. Five healthy subjects will be studied for
 comparison. The investigators will evaluate the subjects while on tilt table for 10 minutes
 and than while mounted from lying down to 70 degrees for additional 10 minutes. Blood
 pressure, heart rate and symptoms will be continuously measured. First study will evaluate
 the blood pressure changes. Second measure will include hand-grip maneuver 1 minute before
 the erect positon. Trans cranial Doppler will assess the intracranial blood flow during the
 position changes.
Study 1:

 10 minutes lying on the tilt table. Performing TCD study at 10 minutes. Raising the tilt
 table to 70 degrees. Performing TCD study 5 minutes after tilting. Measuring blood pressure
 and symptoms for 10 minutes. Returning the tilt bed to supine position.

 Study 2. in continue with study 1:

 10 minutes lying on the tilt table. Performing TCD study at 10 minutes. Performing hand-grip
 at 50-70% grip force for 1 minute Raising the tilt table to 70 degrees. Performing TCD study
 5 minutes after tilting. Measuring blood pressure and symptoms for 10 minutes. Returning the
 tilt bed to supine position.
Inclusion Criteria:

 -  Man or women

 -  18 years of age or older

 -  Diagnosed with orthostatic hypotension due to Parkinson's disease, multiple system
 atrophy or pure autonomic failure

 -  Orthostatic hypotension is not due to drugs, any heart disorder, anemia or dehydration

 Exclusion Criteria:

 -  Pregnant or breast feeding