RMPT for Relapsed/Refractory Multiple Myeloma
RMPT for Relapsed/Refractory Multiple Myeloma
After the discovery of melphalan and prednisone (MP), many clinical trials evaluated the
 efficacy of combination chemotherapy, such as VMCP, VBAP, MOCCA in multiple myeloma (MM)
 patients, without significant clinical benefit. After 40 years, the combination of MP with
 thalidomide (MPT) or lenalidomide (MPR) or bortezomib (MPV) have finally and consistently
 shown additive or synergistic effects.In advanced MM, the combination of melphalan,
 prednisone and thalidomide induced 12% very good partial response (VGPR) rate, while the
 combination of melphalan and bortezomib showed 15% near complete remission (nCR) rate. In
 relapsed patients, the combination of bortezomib with MPT (VMPT) induced 43% VGPR rate.
 Preliminary results indicate that VMPT may induce a CR rate of around 50% in newly diagnosed
 patients (unpublished results).In preclinical studies thalidomide showed more
 anti-angiogenesis activity, while lenalidomide showed more immunomodulatory effects, thus
 suggesting a combined clinical approach for these two drugs. The toxicity profile of
 lenalidomide is completely different from that of thalidomide and no cumulative toxicities
 are expected, again suggesting a combination approach. This study will evaluate the safety
 and efficacy of combining Lenalidomide, Melphalan, Prednisone and Thalidomide (R-MPT) as
 salvage treatment for relapsed/refractory myeloma patients. This association might further
 increase the response rate achieved by the standard oral MPT or MPR regimens.
Inclusion Criteria:

 1. Patient is of a legally consenting age as defined by local regulations.

 2. Patient is, in the investigator(s) opinion willing and able to comply with the
 protocol requirements.

 3. Patient has given voluntary written informed consent before performance of any
 study-related procedure not part of normal medical care, with the understanding that
 consent may be withdrawn by the patient at any time without prejudice to their future
 medical care.

 4. Female patient is either post-menopausal for 24 consecutive months or surgically
 sterilised or agree to continuous abstinence from heterosexual sexual contact or
 willing to use two acceptable method of birth control at the same time (one highly
 effective method and one additional effective method)(Highly Effective Methods:
 Intrauterine device -IUD-; Hormonal -birth control pills, injections, implants-; tubal
 ligation; partner's vasectomy; Additional Effective Methods: Latex condom; Diaphragm;
 Cervical Cap) for 4 weeks prior to beginning study drug therapy, during study drug
 therapy (including dose interruption) and for 4 weeks after discontinuation of
 Lenalidomide therapy.

 5. Male patient agrees to use an acceptable method for contraception (i.e., condom or
 abstinence) during study drug therapy (including dose interruption) and for 4 weeks
 after discontinuation of Lenalidomide therapy.

 6. Patient was previously diagnosed with symptomatic multiple myeloma based on standard
 criteria (12), and has measurable disease, defined as follows:

 -  Secretory myeloma: any quantifiable serum monoclonal protein value (generally,
 but not necessarily, greater than 1 g/dL of IgG M-Protein and greater than 0.5
 g/dL of IgA M-Protein) and, where applicable, urine light-chain excretion of >200
 mg/24 hours;

 -  Non-secretory myeloma: > 30% plasma cells in the bone marrow and at least one
 plasmacytoma > 2cm as determined by clinical examination or applicable
 radiographs (i.e., MRI or CT scan).

 7. Patient is relapsed or refractory after one or two lines of treatment

 8. Patient has a Karnofsky performance status ≥ 60%.

 9. Patient has a life-expectancy > 3 months.

 10. Patient has the following laboratory values within 14 days before Baseline (day 1 of
 the Cycle 1):

 -  Platelet count ³ 100 x 109/L without transfusion support within 7 days before the
 test

 -  Absolute neutrophil count ³ 1.0 x 109/L without the use of growth factors

 -  Total bilirubin £ 1.5 x the ULN

 -  AST (SGOT) and ALT (SGPT) £ 2.5 x ULN

 -  Corrected serum calcium < 14 mg/dl (3.5 mmol/L)

 -  Calculated or measured creatinine clearance: ≥ 20 mL/minute

 Exclusion Criteria:

 1. Any serious medical condition, laboratory abnormality, or psychiatric illness that
 would prevent the subject from signing the informed consent form.

 2. Pregnant or beast feeding females.

 3. Any condition, including the presence of laboratory abnormalities, which places the
 subject at unacceptable risk if he/she were to participate in the study or confounds
 the ability to interpret data from the study.

 4. Use of any other concomitant standard/experimental anti-myeloma drug or therapy

 5. Prior induction therapy with R-MP or M-PT association

 6. Any of the following laboratory abnormalities:

 -  Platelet count < 100 ´ 109/L.

 -  Absolute neutrophil count <1.0 ´ 109/L.

 -  Aspartate transaminase (AST): >2.5 x the upper limit of normal (ULN).

 -  Alanine transaminase (AST): > 2.5 x the ULN.

 -  Total bilirubin: > 1.5 x the ULN.

 -  Corrected serum calcium >14 mg/dL (3.5 mmol/L).

 -  Calculated or measured creatinine clearance <20 mL/minute

 7. Known positive for HIV or active infectious hepatitis, type B or C.

 8. Patient has ³Grade 2 peripheral neuropathy within 14 days before enrollment.

 9. Known hypersensitivity to thalidomide.