PS-341 in Combination With Herceptin in Advanced Breast Cancer That Overexpresses HER-2
PS-341 in Combination With Herceptin in Advanced Breast Cancer That Overexpresses HER-2
The main objective of this study is to determine the feasibility of the combination of the
 proteasome inhibitor bortezomib (PS-341, Velcade) with trastuzumab (Herceptin) and to
 determine the best dose of bortezomib to combine with two trastuzumab schedules, weekly and
 3-weekly.
Phase 1 study to determine the feasibility of the combination of the proteasome inhibitor
 bortezomib (PS-341, Velcade) with trastuzumab (Herceptin) given either weekly or 3-weekly.

 Additionally, hints about efficacy of the combination will be looked upon.
Inclusion Criteria:

 1. Female gender

 2. Age >= 18 years

 3. ECOG performance status < 2

 4. Histologically proven diagnosis of breast cancer

 5. Locally advanced and/or metastatic disease

 6. Life expectancy of three months or longer

 7. No concurrent second malignancy (except for adequately treated basal cell carcinoma of
 the skin, in situ carcinoma of the cervix or contralateral breast cancer). Any prior
 second malignancy must be in remission for >= 5 years (except for contralateral breast
 cancer).

 8. No other serious illness or medical condition including:

 -  History of documented congestive heart failure; angina pectoris requiring
 antianginal medication; evidence of recent (< 6 months) transmural infarction on
 electrocardiogram (ECG); poorly controlled hypertension (e.g. systolic > 180 mmHg
 or diastolic greater than 100 mmHg); clinically significant valvular heart
 disease; or high-risk uncontrolled arrhythmias.

 -  Chronic lung disease

 -  History of significant neurological or psychiatric disorders that would prohibit
 the understanding and giving of informed consent, including psychotic disorders,
 mental retardation, and dementia.

 -  Active concurrent infection

 9. No symptomatic central nervous system (CNS) metastases

 10. No rapidly progressive visceral metastases requiring immediate chemotherapy

 11. No concurrent anti-cancer treatment is allowed.

 12. Prior investigational biological agents are allowed, with the exception of anti-HER-2
 therapy for any reason.

 13. Previous hormonal therapy is allowed, as adjuvant and/or for metastatic breast cancer
 (MBC).

 14. Adjuvant and MBC chemotherapy allowed, provided that a minimum of 4 weeks interval has
 elapsed between last chemotherapy administration and first study drug dose. All
 patients who, in the opinion of the investigator, could benefit from single agent
 Herceptin® and are not considered suitable for treatment with chemotherapy plus
 Herceptin® can be considered for this protocol.

 15. A maximum cumulative dose of previous doxorubicin < 360 mg/m2 or a maximum cumulative
 dose of epirubicin < 720 mg/m2

 16. Concomitant use of bisphosphonates is allowed, however if bisphosphonates are started
 during the trial for worsening bone pain, patients should be assessed for possible
 progressive disease.

 17. Adequate organ function as defined by:

 -  Neutrophils >= 1.5 x 10^9/L

 -  Platelets >= 100 x 10^9/L

 -  Bilirubin <= 1.5 x upper limit of normal (ULN)

 -  Transaminases <= 2.5 x ULN or <= 5 x ULN if liver metastasis

 -  Creatinine <= 1.5 x ULN

 18. Overexpression of HER-2 in the invasive component of the primary tumor, according to
 one of the following definitions:

 -  3+ overexpression by immunohistochemistry (IHC) or

 -  2+ overexpression by IHC and fluorescence in situ hybridization (FISH) test
 demonstrating c-erbB2 gene amplification (ratio of c-erbB2 gene signals to
 centromere 17 signals > 2)

 19. Baseline left ventricular ejection fraction (LVEF) > 50% measured by multiple gated
 acquisition scan (MUGA) or echocardiography

 20. Evaluable or uni-dimensionally measurable disease according to the Response Evaluation
 Criteria in Solid Tumors (RECIST) criteria

 21. Women of childbearing potential must have a negative serum or urine pregnancy test and
 be willing to use acceptable methods of birth control.

 22. Absence of any psychological, familial, sociological or geographical condition
 potentially hampering compliance with the study protocol and follow-up schedule; those
 conditions should be discussed with the patient before registration in the trial.

 23. Before patient registration/randomization, informed consent must be given according to
 International Conference of Harmonization/European Union Good Clinical Practice
 (ICH/EU GCP), and national/local regulations.