Roles of T Helper 1 Cytokines in Type 1 Diabetes
Roles of T Helper 1 Cytokines in Type 1 Diabetes
The mechanism of β cell destruction in Type 1 diabetes is not exactly known, Our hyphotesis
 is that interferon gamma, interleukin-2 and tumor necrotizan factor alpha have impotant roles
 in β cell destruction.
T helper (h)1 cells are known to have important roles in the destruction or/and
 dedifferentiation of β-cells in type 1 diabetes (T1D). Significant increase in
 IFN-γ-producing Th1 cells in the pancreas and in the serum levels were determined in type 1
 diabetic patients at diabetes oneset. This data indicated that this proinflammatory mediator
 serve as a biomarker of advanced autoimmunity. We aimed to investigate the relationship
 between Th1 cytokines (IFN-γ, IL-2 and TNF-α) and T1D and the effect of those cytokines on
 β-cell function.
Inclusion Criteria:

 -  Patients giving consent to participate the study

 -  Patients with type 1 diabetes according to WHO definiton

 Exclusion Criteria:

 -  Acute and chronic inflammatory diseases,

 -  significant concomitant diseases which may interfere with glucose metabolism

 -  cancers,

 -  hemoglobinopathies,

 -  recently received antibiotics,

 -  drugs influencing β-cell function and

 -  insulin sensitivity or anti-inflammatory drugs

 -  recent history of trauma