De-escalation Protocols in Locoregionally Advanced Nasopharyngeal Carcinoma
De-escalation Protocols in Locoregionally Advanced Nasopharyngeal Carcinoma
The purpose of this study is to explore the efficacy and safety of image guided de-escalation
 protocols in patients with locoregionally advanced nasopharyngeal carcinoma (NPC). So the
 investigators studied whether toxicities reducing treatment with omitted concurrent
 chemotherapy after good response to induction chemotherapy would maintain survival outcomes
 while improving tolerability for patients with locoregionally advanced nasopharyngeal
 carcinoma.
Inclusion Criteria:

 -  Histological diagnosis of nasopharyngeal carcinoma

 -  Stage III or IVA according to UICC/AJCC 8th staging system

 -  Age ≥18

 -  No prior anti-tumor treatment

 -  Karnofsky Performance Score (KPS)≥70

 -  Adequate blood supply

 -  Informed consent obtained

 Exclusion Criteria:

 -  Can not take contrast-MRI imaging

 -  Pregnant

 -  Combined with other malignant tumor (except basal cell carcinoma of skin)