DIAFAX I+II-Effects of Inhalative Anesthetics on Left Ventricular Diastolic Function
DIAFAX I+II-Effects of Inhalative Anesthetics on Left Ventricular Diastolic Function
Anaesthetics may impair the diastolic function of the heart, but the importance of this
 finding for patients has not been sufficiently examined. Specially the effects on diastolic
 function in patients with diastolic dysfunction has to be determined. The aim of this study
 is to examine the effect of isoflurane (only part I), sevoflurane and desflurane (part I+II)
 on the diastolic left ventricular function by doppler echocardiography.
In part I, 60 healthy young subjects free from cardiovascular disease will be examined. In
 part II, 50 patients with impaired diastolic but preserved systolic function, i.e., patients
 with arterial hypertension and ejection fraction > 50%. Doppler echocardiography will be
 performed at baseline before induction of anaesthesia, during anaesthesia in the
 spontaneously breathing patient, and in the mechanically ventilated patient.
Inclusion Criteria:

 -  part I: 18- to 50-year-old patients undergoing surgical procedures under general
 anesthesia

 -  part II: 50-years-old patients or older with arterial hypertension under chronic
 antihypertensive medication subsequently undergoing surgical procedures under general
 anesthesia, EF >50%

 Exclusion Criteria:

 -  part I: any cardiac or pulmonary disease, any medication with cardiovascular effects
 or side effects, body mass index > 30 kg/m2, esophageal reflux, emergency

 -  part II: History of myocardial infarction or coronary revascularization, severe lung
 disease, body mass index > 30 kg/m2, esophageal reflux, emergency