Clinical Research on the Effect of Aspirin on the Disease Free Survival Rate of Esophageal Carcinoma
Clinical Research on the Effect of Aspirin on the Disease Free Survival Rate of Esophageal Carcinoma
Esophageal cancers are the seventh most common cancer in the world and one of the most common
 causes of cancer deaths. In some parts of China, the incidence of SCC is among the highest in
 the world. Despite surgery and adjuvant radiotherapy, the prognosis for SCC patients was
 disappointing. There is therefore an urgent need for new prevention and treatment strategies.

 Epidemiological investigations have found that about 25% of human tumors are associated with
 chronic inflammation caused by a variety of causes, and chronic inflammation activates
 nuclear transcription factors (nuclear Factor,NF), induces gene and epigenetic changes such
 as DNA methylation, tumor suppressor gene point mutations, and post-translational
 modification, and participates in the process of tumorigenesis. It has been noted that the
 long-term regularity of the use of non-steroidal anti-inflammatory drugs aspirin can reduce
 the incidence and mortality of a variety of tumors, including esophageal cancer.

 Aspirin is the earliest, most extensive and common antipyretic analgesics and anti-rheumatism
 drugs used to play an anti-inflammatory role by inhibiting the synthesis of PGs. COX-2 is a
 key enzyme in the synthesis of PGs, so it is speculated that the anti-tumor effect of aspirin
 inhibits the PGs of COX and its inhibition.
Inclusion Criteria:

 -  Hospitalized patients with malignant tumors after radical operation of esophageal
 squamous cell carcinoma without merging other parts; Pathological results are shown as
 all staging; Immunohistochemical staining showed positive COX-2 expression; Aspirin or
 other non-steroidal anti-inflammatory drugs have not been taken in the past; No
 abnormalities found in coagulation function; Between the ages of 18-70 and five,
 gender is not limited; Patient KPS≥90, expected survival period of more than 6 months;
 Patient Signs Informed Consent statement; Pregnant women with fertility must be
 negative in pregnancy trials.

 Exclusion Criteria:

 -  Severe coagulation dysfunction; Severe liver, kidney and cardiac dysfunction; The
 lesion failed to completely remove; Active digestive tract Ulcers; Reflux esophageal
 disease; Allergies to aspirin or other drugs containing salicylic acid; History of
 asthma caused by salicylic acid salts or salicylate containing substances and
 non-steroidal anti-inflammatory drugs; COX-2 expression of immune tissue chemical
 staining weak or not expressed; Wide transfer of the whole body; Ever taken aspirin or
 other non-steroidal anti-inflammatory drugs; Pregnant and lactating women.