Treatment Efficacy of Budesonide/Formoterol in Cough Variant Asthma and Typical Asthma Patients
Treatment Efficacy of Budesonide/Formoterol in Cough Variant Asthma and Typical Asthma Patients
Bronchial asthma is a common respiratory disease characterized by chronic airway
 inflammation, which have been affecting about 1-18% of the population in the world, causing
 tremendous economic burden for the patients and countries. Generally, asthma is a
 heterogeneous disease, and it could be classified into many types on the basis of symptoms,
 that is, typical asthma, cough variant asthma, and chest tightness variant asthma etc.
 Typical asthma (TA) is defined according to the history of repeated respiratory symptoms such
 as wheeze, shortness of breath, chest tightness, and cough, usually with reversible airflow
 limitation, airway hyper-responsiveness, and airway remodeling. Cough variant asthma (CVA) is
 characterized by the single manifestation, recurrent cough, which could be improved after the
 use of bronchodilators. However, according to different guidelines, it is still controversial
 on the treatment of CVA and TA. The guidelines of Global Initiative for Asthma(GINA) in 2014
 put forward the treatment of TA patients, but did not list the treatment specific to CVA. The
 guideline of ACCP（American College of Chest Physicians） and cough guidelines of China are
 proposed to treat the CVA effectively with bronchial diastolic drug. Inhaled corticosteroids
 (ICS) and leukotriene receptor antagonists are effective for the treatment of CVA. Currently,
 more and more studies supported that application of ICS combined with bronchial dilation
 agents is more beneficial to CVA patients. Budesonide/formoterol is a compound of ICS and
 long-acting beta2-agonist(LABA), which can not only be used as a maintenance medication, but
 also be used as a relief medication, namely, budesonide/formoterol treatment regimen for
 SMART (Symbicort as both maintenance and reliever therapy). Most studies show that SMART
 treatment can be used in the treatment of TA patients. But the study on whether
 budesonide/formoterol can be used to treat CVA is still little. To provide basis for clinical
 medication guidance for patients with CVA and TA, this study will enroll 30 patients with TA
 or CVA , who will be required to adopt the SMART regimen in the following 6 months.The
 symptom score, airway inflammation, pulmonary function and airway reactivity changes, will be
 measured every mouth. After the study finished, the investigators will compare the difference
 between the two groups.
Inclusion Criteria:

 1. aged 15-75

 2. first diagnosed corresponding to the diagnostic standards established by Asthma
 Committee, Respiratory Society, Chinese Medical Association, or previously diagnosed
 asthma without regular treatment

 3. Mch bronchial provocation test is positive

 4. the chest X-ray is normal.

 Exclusion Criteria:

 1. accompanied by other disease of respiratory system

 2. combined with serious illness of other system, such as myocardial infarction, severe
 arrhythmia, malignant tumors and so on

 3. women with pregnancy or lactation.