Modulation of Cognition and Brain Connectivity by Noninvasive Brain Stimulation in Patients With Mild Cognitive Impairment Due to Alzheimer's Disease
Modulation of Cognition and Brain Connectivity by Noninvasive Brain Stimulation in Patients With Mild Cognitive Impairment Due to Alzheimer's Disease
Alzheimer's disease (AD) has a detrimental impact on cognitive functions. Based on pilot
 studies results in patients with neurodegenerative brain diseases the investigators aim for
 promoting the brain plasticity and improving cognition by noninvasive brain stimulation
 (NIBS) in healthy young, healthy aged and subjects with mild cognitive impairment due to AD.
 Mild cognitive impairment (MCI) is an intermediate stage between the expected cognitive
 decline of normal aging and the more-serious decline of dementia. Different new brain
 targets, cognitive tasks and stimulation protocols will be tested and optimized for specific
 subject groups. Design of a functional MRI (fMRI) - repetitive transcranial magnetic
 stimulation (rTMS) - fMRI study will enable us to explore and identify effect of age,
 presence of the disease and genetic risk factor (APOE4) on repetitive transcranial magnetic
 stimulation (rTMS)-induced changes in cognition and related brain connectivity/activations.
 The study results will improve our understanding of healthy and pathological brain aging and
 will provide novel information about the usefulness of NIBS in specific subject groups. These
 results will have an important impact on future non-pharmacological treatment strategies.
Intensified intermittent theta-burst stimulation (iTBS) protocol will be applied in the MCI
 study group. A two-parallel-group, randomized, placebo controlled design will be used. Ten
 MCI subjects will be stimulated in a week-long therapeutical sessions. Other ten MCI subjects
 will be stimulated with the same protocol using sham stimulation. The investigators will
 study the change in subjects immediately after and again at a two-weeks follow-up visit after
 the end of the last stimulation session.
Inclusion Criteria:

 -  amnestic single or multi-domain mild cognitive impairment patients in accordance with
 diagnostic criteria (Albert et al., 2011)

 Exclusion Criteria:

 psychiatric disorders, including major depression, major vascular lesions, and other brain
 pathologies detected by MRI that might present with cognitive decline

 -  a cardio pacemaker or any MRI-incompatible metal in the body

 -  epilepsy

 -  any diagnosed psychiatric disorder

 -  alcohol/drug abuse

 -  lack of cooperation

 -  presence of dementia