Observational Study of Azilsartan/Chlorthalidone and Irbesartan/Hydrochlorothiazide in Hypertension and Obesity.
Observational Study of Azilsartan/Chlorthalidone and Irbesartan/Hydrochlorothiazide in Hypertension and Obesity.
This is an observational prospective study of azilsartan medoxomil / chlorthalidone compared
 with irbesartan / hydrochlorothiazide in routine therapy of patients with arterial
 hypertension and obesity.
Observational Prospective stUdy of aZilsartan medoxomil/ chlorthalidone compared with
 irbesartan/hydrochlorothiaZide combination therapy in patients with arteriaL hypertension and
 obEsity in routine clinical practice (PUZZLE).

 The study population is 94 patients with untreated or poorly controlled arterial hypertension
 and obesity.

 The main inclusion criteria are:

 1. Male and female 35-55 year old.

 2. Diagnosis of essential arterial hypertension I-II grade.

 3. Patients with obesity (BMI ≥ 30 kg/m²)

 4. Patients with untreated arterial hypertension (clinic SBP ≥ 140 mmHg, DBP ≥ 90 mmHg and
 no previous antihypertensive treatment.

 5. Patients with poorly controlled arterial hypertension (clinic SBP ≥ 140 mmHg, DBP ≥ 90
 mmHg on previous antihypertensive treatment.

 6. Written informed consent.

 The main exclusion criteria are:

 1. Patients with symptomatic organ damage (myocardial infarction, stroke, angina pectoris,
 chronic kidney disease ≥ 4 grade, diabetes).

 2. Patients with secondary arterial hypertension.

 3. Patients with intolerance of angiotensin II receptor blockers, thiazide diuretic.

 4. Patients with contraindication to study drugs in accordance with Russian instruction.

 5. Patients currently enrolled in other clinical trials. The treatment period is 6 months.
 The study plan includes 4 basic and 1 additional visits are planned: initial visit, 3
 follow-ups (including additional) and study-end visit.
Inclusion Criteria:

 1. male and female 35-55 year old,

 2. diagnosis of I-II grade essential AH,

 3. patients with obesity (BMI ≥ 30 kg/m²),

 4. patients with untreated AH (office SBP ≥ 140 mmHg, DBP ≥ 90 mmHg, no previous
 antihypertensive therapy),

 5. patients with poorly controlled AH (office SBP ≥ 140 mmHg, DBP ≥ 90 mmHg on previous
 antihypertensive therapy),

 6. written informed consent form (ICF).

 Exclusion Criteria:

 1. patients with symptomatic organ damage (myocardial infarction, stroke, angina
 pectoris, chronic kidney disease stage ≥ 4, diabetes),

 2. patients with intolerance of ARB, thiazide diuretics,

 3. secondary AH,

 4. patients with contraindication to study drugs in accordance with Russian instruction,

 5. patients currently enrolled in other clinical trials.