Hematopoietic Stem Cell Transplant for High Risk Hemoglobinopathies
Hematopoietic Stem Cell Transplant for High Risk Hemoglobinopathies
This is a study to collect the outcomes of stem cell transplantation for patients with
 hematologic diseases other than cancer.
Inclusion Criteria:

 -  Diagnosis of Sickle Cell Disease, Thalassemia, Diamond Blackfan Anemia or other
 non-malignant hematologic disorders for which a stem cell transplant is indicated

 -  Acceptable stem cell source identified

 -  Performance status of ≥ 70% (Karnofsky),or ≥ 70 (Lansky play score)

 -  Creatinine <2.0 mg/dl for adults or glomerular filtration rate > 50 ml/min for
 children

 -  Bilirubin, Aspartate Aminotransferase, Alkaline phosphatase <5 times the upper limit
 of institutional normal

 -  Absence of decompensated congestive heart failure, or uncontrolled arrhythmia and left
 ventricular ejection fraction > 40%

 Exclusion Criteria:

 -  active, uncontrolled infection

 -  pregnant or breastfeeding

 -  HIV positive