Aspergillus PCR Early Detection in High Risk Oncohematological Patients
Aspergillus PCR Early Detection in High Risk Oncohematological Patients
ADVANCE THERAPY ASPERGILLOSIS INVASIVE BY PCR DETECTION
ADVANCE THERAPY ASPERGILLOSIS INVASIVE IN PATIENTS HIGH RISK ONCOHEMATOLOGICAL PCR USING FOR
 EARLY DETECTION OF ASPERGILLUS
Inclusion Criteria:

 -  Signature of informed consent to participate in the study.

 -  Adult patients (> 18 years), diagnosed with acute myelogenous leukemia or
 myelodysplastic syndrome with chemotherapy (CT) intensive, or admitted to undergo
 allogeneic hematopoietic progenitor cells, or transplantation with graft versus host
 disease.

 -  The patient should be included in this protocol from the start of their chemotherapy
 or conditioning therapy as reflected in another section.

 Exclusion Criteria:

 -  Employment of antifungal prophylaxis (30 days prior to inclusion) with triazole /
 polyene with activity against Aspergillus (itraconazole, voriconazole, posaconazole,
 amphotericin B inhalation).

 -  Use of other systemic antifungal activity against Aspergillus (amphotericin,
 terbinafine, flucytosine, echinocandins, etc.). Therefore it will Fluconazole
 prophylaxis exclusively.

 -  Background of IFI proven / probable prior

 -  Probable IFI / tested at the time of inclusion in the study.

 -  Exclusion will cause a lack of compliance with the inclusion criteria.

 -  Patients who have a lack of follow biweekly with galactomannan or PCR. Have a
 bacterial infection not properly treated and controlled before starting empirical
 antifungal treatment (according to the definition given above). And finally they have
 a neutropenia of short duration that it creates a significant risk of IFI. This
 information will not be known logically to include the patient in the study.