Physical and Cognitive Function - Look AHEAD Ancillary Study
Physical and Cognitive Function - Look AHEAD Ancillary Study
Obesity is associated with physical disability through both direct pathways (e.g., lower
 extremity pain, insufficient muscle strength) and indirect pathways (obesity-related
 comorbidities and inflammation). Furthermore, diabetes, a major obesity-related health
 condition, is associated with increased risk of disability and accelerated declines in
 physical and cognitive function. The investigators preliminary data suggest that intentional
 weight loss improves physical function, and there is strong circumstantial evidence that it
 would also benefit cognitive function.

 To evaluate the role of intentional weight loss on physical and cognitive function, the
 investigators propose an ancillary study to the on-going Look AHEAD (Action for Health in
 Diabetes) trial. Look AHEAD is a multi-center, randomized clinical trial to examine the
 effects of a 4-year lifestyle intervention designed to achieve and maintain weight loss
 through decreased caloric intake and exercise in overweight or obese men and women aged 45-74
 years with type 2 diabetes. The investigators propose to add validated and well-established
 measures of physical and cognitive performance to the year 8 follow-up visit - during the
 trial's weight maintenance phase - in ~1000 participants at 4 of the 16 Look AHEAD field
 sites (Colorado, Memphis, Pennington and Pittsburgh).

 The specific aims of this ancillary study are: 1) To determine the long-term effects of a
 lifestyle intervention designed to achieve and maintain weight loss on physical function; and
 2) To determine the long-term effects of a lifestyle intervention designed to achieve and
 maintain weight loss on cognitive function. In addition, the investigators hypothesize that
 in the intervention group, larger initial weight loss, better weight loss maintenance, and
 higher physical activity will be associated with better physical and cognitive function. The
 investigators also hypothesize that in the control group weight loss will be associated with
 worse physical and cognitive function than in those who are weight stable or who have gained
 weight.

 The number of obese older adults is rising rapidly and there are few data to guide an
 evidence-based clinical response to their management. The results of this study will provide
 the first direct evidence of the role of long-term intentional weight loss on the maintenance
 of physical and cognitive function in older obese adults with diabetes. Since this study is
 being done as an ancillary study to an on-going trial it can be done in a timely and
 cost-efficient manner.
Inclusion Criteria:

 -  The only inclusion criterion is that the participant is considered "active" at his/her
 Year 8 or Year 9 visit in the main study.

 Exclusion Criteria:

 -  The only exclusion criterion is the person is not willing to participate in this
 ancillary study.