The Association of Costimulatory Molecules and PPAR-polymorphisms With Autoimmune Thyroid Disease in Taiwan
The Association of Costimulatory Molecules and PPAR-polymorphisms With Autoimmune Thyroid Disease in Taiwan
Autoimmune thyroid disease is the most common organ-specific autoimmune disease. AITD include
 Graves' disease and Hashimoto's thyroiditis. Although the pathogenesis of AITD remains
 unclear, it is generally thought that the mechanisms of the disease is a complex disease in
 which susceptibility genes and environmental triggers act in concert to initiate the
 autoimmune response to the thyroid.

 The initial step of thyroid autoimmunity is the activation of T cells. The activation of T
 cell requires two signals: firstly, thyroid follicular cells or antigen presenting cells
 binds to T cell receptor through antigenic HLA complex. Secondly, the activation of T cells
 is also required the interaction of costimulatory molecules between thyroid follicular cells
 and immune cells, including CTLA-4, CD 40, CD28, ICOS. PPAR- is a kind of intranuclear
 transcription factor, associated with adipogenesis and inflammation. Some reports showed that
 PPAR- polymorphism may have a protective effect from Graves' ophthalmopathy.

 The goal of the study is to investigate the relationship among SNP and mRNA of costimulatory
 molecules and PPAR- , serum cytokine including TNF- and sIL-2R, and clinical characteristics
 in AITD patients. From the study, we hope to clarify the role of costimulatory molecules and
 PPAR- polymorphism in AITD.
Autoimmune thyroid disease is the most common organ-specific autoimmune disease. AITD include
 Graves' disease and Hashimoto's thyroiditis. Although the pathogenesis of AITD remains
 unclear, it is generally thought that the mechanisms of the disease is a complex disease in
 which susceptibility genes and environmental triggers act in concert to initiate the
 autoimmune response to the thyroid.

 The initial step of thyroid autoimmunity is the activation of T cells. The activation of T
 cell requires two signals: firstly, thyroid follicular cells or antigen presenting cells
 binds to T cell receptor through antigenic HLA complex. Secondly, the activation of T cells
 is also required the interaction of costimulatory molecules between thyroid follicular cells
 and immune cells, including CTLA-4, CD 40, CD28, ICOS. PPAR- is a kind of intranuclear
 transcription factor, associated with adipogenesis and inflammation. Some reports showed that
 PPAR- polymorphism may have a protective effect from Graves' ophthalmopathy.

 The goal of the study is to investigate the relationship among SNP and mRNA of costimulatory
 molecules and PPAR- , serum cytokine including TNF- and sIL-2R, and clinical characteristics
 in AITD patients. From the study, we hope to clarify the role of costimulatory molecules and
 PPAR- polymorphism in AITD.
Inclusion Criteria:

 -  Autoimmune thyroid patients

 -  patients who cut Nodular Goiter in Wanfang Hospital

 Exclusion Criteria:

 -  none