Study to Evaluate the Efficacy and Safety of Eribulin Mesylate in Combination With Pembrolizumab in Participants With Metastatic Triple-Negative Breast Cancer (mTNBC)
Study to Evaluate the Efficacy and Safety of Eribulin Mesylate in Combination With Pembrolizumab in Participants With Metastatic Triple-Negative Breast Cancer (mTNBC)
This is an open-label, single-arm, multicenter, Phase 1b/2 study of eribulin mesylate in
 combination with pembrolizumab in participants with mTNBC previously treated with 0 (stratum
 1) or 1 to 2 (stratum 2) lines of systemic anticancer therapy (cytotoxic or targeted
 anticancer agents) in the metastatic setting.
The Phase 1b part will evaluate the safety and tolerability of eribulin mesylate in
 combination with pembrolizumab. Approximately 6 participants may be enrolled in the Phase 1b
 part of the study. The Phase 2 part will evaluate the tumor objective response rate (ORR)
 when treated with eribulin mesylate in combination with pembrolizumab in all participants and
 will also evaluate ORR in stratum 2 participants and compare with the historical response
 rate of pembrolizumab monotherapy 10 percent (%) in participants with mTNBC previously
 treated with >=1 line of prior chemotherapy in the metastatic setting. Approximately 170
 mTNBC participants (including participants in Phase 1b who are on RP2D level) will be
 enrolled in Phase 2.
Inclusion Criteria:

 1. Females or males, aged >=18 years at the time of signing the informed consent form
 (ICF).

 2. mTNBC (confirmed from most recent tissue sample) meeting the following criteria:

 1. Estrogen receptor (ER) and progesterone receptor negative (a tumor is ER and/or
 progesterone receptor positive if at least 1 percent (%) of the cells examined
 have estrogen and/or progesterone receptors) and human epidermal growth factor
 receptor 2 (HER2) negative (defined as immunohistochemistry [IHC] less than (<)
 2+ or fluorescence in situ hybridization [FISH] negative).

 2. Previously treated with 0 to 2 lines of systemic anticancer therapy (cytotoxic or
 targeted anticancer agents) in the metastatic setting. Hormonal therapy and bone
 metastases treatment (example, bisphosphonates, denosumab, etc) are not
 considered forms of systemic anticancer therapy.

 3. Presence of measurable disease meeting the following criteria:

 1. At least 1 lesion of >=10 millimeter (mm) in long axis diameter for nonlymph
 nodes or >=15 mm in short axis diameter for lymph nodes that is serially
 measurable according to Response Evaluation Criteria in Solid Tumors version 1.1
 (RECIST 1.1) using computerized tomography (CT) or magnetic resonance imaging
 (MRI) or panoramic and close-up color photography.

 2. Lesions that have had radiotherapy must show subsequent radiographic evidence of
 increased size to be deemed a target lesion.

 4. Life expectancy of >=3 months.

 5. Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0 or 1.

 6. Adequate renal function as evidenced by serum creatinine less than or equal to (<=)
 1.5 milligram per deciliter (mg/dL) or calculated creatinine clearance >=50 millimeter
 per minute (mL/min) according to the Cockcroft and Gault formula.

 7. Adequate bone marrow function, defined as:

 1. Absolute neutrophil count (ANC) >=1.5*10^9/L.

 2. Hemoglobin (Hb) >=10.0 gram per deciliter (g/dL) (can be corrected by growth
 factor or transfusion).

 3. Platelet count >=100*10^9/L.

 8. Adequate liver function, defined as:

 1. Total bilirubin <=1.5*upper limit of normal (ULN).

 2. Alkaline phosphatase (ALP), alanine aminotransferase (ALT), and aspartate
 aminotransferase (AST) <=3*ULN unless there are bone metastases, in which case
 liver specific alkaline phosphatase must be separated from the total and used to
 assess the liver function instead of the total alkaline phosphatase. ALT and AST
 <= 5*ULN if participant has liver metastases.

 9. Resolution of all chemotherapy-related or radiation-related toxicities to Grade 1
 severity or lower, except for stable sensory neuropathy (<= Grade 2) and alopecia.

 10. Archived tissue sample or new biopsy sample.

 11. Females must not be lactating or pregnant at Screening or Baseline (as documented by a
 negative beta-human chorionic gonadotropin [B-hCG] (or human chorionic gonadotropin
 [hCG]) test with a minimum sensitivity of 25 International units per litre (IU/L) or
 equivalent units of B-hCG [or hCG]). A separate baseline assessment is required if a
 negative screening pregnancy test was obtained more than 72 hours before the first
 dose of study drug.

 12. All females will be considered to be of childbearing potential unless they are
 postmenopausal (amenorrheic for at least 12 consecutive months, in the appropriate age
 group, and without other known or suspected cause) or have been sterilized surgically
 (that is, bilateral tubal ligation, total hysterectomy or bilateral oophorectomy, all
 with surgery at least 1 month before dosing).

 13. Females of childbearing potential must not have had unprotected sexual intercourse
 within 30 days before study entry and must agree to use a highly effective method of
 contraception (example, total abstinence, an intrauterine device, a double-barrier
 method [such as condom plus diaphragm with spermicide], a contraceptive implant, a
 combination oral contraceptive (estrogen/progesterone), or have a vasectomized partner
 with confirmed azoospermia) throughout the entire study period and for 120 days after
 study drug discontinuation. If currently abstinent, the participant must agree to use
 a double barrier method as described above if she becomes sexually active during the
 study period or for 120 days after study drug discontinuation. Females who are using
 hormonal contraceptives must have been on a stable dose of the same hormonal
 contraceptive product for at least 28 days before dosing and must continue to use the
 same contraceptive during the study and for 120 days after study drug discontinuation.

 14. Males who have had a successful vasectomy (confirmed azoospermia) or they and their
 female partners meet the criteria above (that is, not of childbearing potential or
 practicing highly effective contraception throughout the study period or for 120 days
 after study drug discontinuation). No sperm donation is allowed during the study
 period or for 120 days after study drug discontinuation.

 15. Willing and able to comply with all aspects of the treatment protocol.

 16. Provide written informed consent.

 Exclusion Criteria:

 1. Previous treatment with eribulin mesylate or any anti-programmed death receptor-1
 (anti-PD-1), programmed death receptor ligand-1 (PD-L1), or PD-L2 agent.

 2. Active autoimmune disease that has required systemic treatment in the past 2 years
 (that is, with use of disease modifying agents, corticosteroids, or immunosuppresive
 drugs). Replacement therapy (example, thyroxine, insulin, or physiologic
 corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc) is not
 considered a form of systemic treatment.

 3. Less than 6 months since prior adjuvant chemotherapy.

 4. Current enrollment in another interventional clinical study or used any
 investigational drug or device within the past 28 days preceding informed consent.

 5. Treatment with chemotherapy or biological therapy within the previous 3 weeks,
 radiation or small molecule targeted therapy within the previous 2 weeks.

 6. Known central nervous system (CNS) disease, except for those participants with treated
 brain metastasis who are stable for at least 1 month, having no evidence of
 progression or hemorrhage after treatment and no ongoing requirement for
 corticosteroids, as ascertained by clinical examination and brain imaging (MRI or CT)
 during the screening period.

 7. Known history of human immunodeficiency virus (HIV) positive.

 8. Known active hepatitis B (example, HBsAg reactive) or hepatitis C (example, hepatitis
 C virus ribonucleic acid (HCV RNA) detected).

 9. Existing anticancer treatment-related toxicities of Grades >= 2 (except for alopecia
 and Grade 2 sensory neuropathy) according to Common Terminology Criteria for Adverse
 Events (CTCAE v4.03).

 10. Any other malignancy that required treatment or has shown evidence of recurrence
 (except for nonmelanoma skin cancer, or histologically confirmed complete excision of
 carcinoma in situ) during the 5 years prior to enrollment in this study.

 11. History of significant cardiovascular disease, defined as:

 1. congestive heart failure greater than New York Heart Association (NYHA) Class II
 according to the NYHA Functional Classification.

 2. unstable angina or myocardial infarction within 6 months of enrollment.

 3. serious cardiac arrhythmia.

 12. Clinically significant electrocardiogram (ECG) abnormality, including a marked
 Baseline prolonged QT interval/corrected QT interval ([QT/QTc], example, a repeated
 demonstration of a QTc interval >500 millisecond [ms]).

 13. History of concomitant medical conditions or infectious diseases that, in the opinion
 of the investigator, would compromise the participant's ability to safely complete the
 study.

 14. Hypersensitivity to the active substance or any other excipients of the eribulin
 mesylate drug product, or severe hypersensitivity (>=Grade 3) to pembrolizumab and/or
 any of its excipients.

 15. Scheduled for major surgery during the study.

 16. Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy
 (in dosing exceeding 10 mg daily of prednisone equivalent) or any other form of
 immunosuppressive therapy within 7 days prior to the first dose of trial treatment.
 The use of physiologic doses of corticosteroids may be approved after consultation
 with the sponsor.

 17. Has a history of (non-infectious) pneumonitis that required steroids or current
 pneumonitis.

 18. Has a history of interstitial lung disease.

 19. Has an active infection requiring systemic therapy.

 20. Has received a live-virus vaccination within 30 days of planned start of study
 therapy. Seasonal flu vaccines that do not contain live virus are permitted.

 21. The investigator's belief that the participant is medically unfit to receive eribulin
 mesylate and pembrolizumab or unsuitable for any other reason.