Comparison of the Efficacy of Phototherapy Using Blue LED's With Wavelength 478 vs. 459 nm.
Comparison of the Efficacy of Phototherapy Using Blue LED's With Wavelength 478 vs. 459 nm.
Treatment of neonatal jaundice is phototherapy with blue light at wavelength about 460 nm and
 irradiance > 30 uw/cm2/nm. Though, recent in vitro models have suggested that a wavelength of
 478 nm should be optimal in reducing total serum bilirubin. The aim of this study is
 therefore to compare the efficiency of phototherapy with light emitting diodes (LED's) of 478
 vs. 459 nm., respectively.
This is a prospective randomised study of the efficacy of phototherapy. Inclusion criteria
 are gestational age > 33 weeks and birth weight > 1800 grams, uncomplicated neonatal
 jaundice. The infants should be treated with phototherapy in a cradle for 24 hours, which is
 routine standard of care. Exclusion criteria is haemolytic disease. Total serum bilirubin
 (TSB) is measured before and after 24 hours of phototherapy. The infants are enrolled and
 randomised consecutively by the neonatologist using sealed and opaque envelopes.

 Power calculation based on expected difference in decrease of TSB of 6% between the two
 groups and a significance level of 0.05, showed that 48 infants should be enrolled in each
 group.
Inclusion Criteria:

 -  Indication for phototherapy with single light

 -  Gestational age > 33 weeks

 -  Birth weight > 1800 grams

 -  Should be treatable in a cradle

 Exclusion Criteria:

 -  Haemolytic disease

 -  Indication for double/triple phototherapy or exchange transfusion