Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Alobresib (Formerly GS-5829) in Adults With Advanced Solid Tumors and Lymphomas and in Combination With Exemestane or Fulvestrant in Adults With Estrogen Receptor Positive Breast Cancer
Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Alobresib (Formerly GS-5829) in Adults With Advanced Solid Tumors and Lymphomas and in Combination With Exemestane or Fulvestrant in Adults With Estrogen Receptor Positive Breast Cancer
The primary objectives of this study are to characterize the safety and tolerability and
 determine the maximum tolerated dose (MTD) or recommended dose for phase 2 study (RDP2) of
 alobresib as a monotherapy in participants with advanced solid tumors and lymphomas, and in
 combination with exemestane or fulvestrant in participants with advanced estrogen receptor
 positive breast cancer.
Key Inclusion Criteria:

 -  Group 1: Histologically or cytologically confirmed advanced malignant solid tumor or
 lymphoma (any subtype) that is refractory to or intolerant of standard therapy or for
 which no standard therapy is available

 -  Group 2: Post-menopausal women with advanced stage estrogen receptor positive breast
 cancer who are candidates for exemestane or fulvestrant

 -  Group 3: Individuals with lymphoma are limited to diffuse large B-cell lymphoma and
 peripheral T-cell lymphoma that are refractory to or intolerant of standard therapy or
 for which no standard therapy is available

 -  Eastern Cooperative Oncology Group (ECOG) Performance Status of ≤ 1

 -  Adequate organ function defined as follows:

 -  Hematologic: Platelets ≥ 100 x 10^9/L; Hemoglobin ≥ 9.0 g/ dL; Absolute
 neutrophil count (ANC) ≥ 1.5 x 10^9/L (without platelet transfusion or any growth
 factors within previous 7 days of the hematologic laboratory values obtained at
 screening visit). Participants in the Group 3 lymphoma expansion may be enrolled
 with an ANC of ≥ 1.0 x 10^9 /L; Platelets ≥ 75 x 10^9 /L.

 -  Hepatic: Aspartate transaminase (AST) / Alanine transaminase (ALT) ≤ 2.5 x upper
 limit of normal (ULN) (if liver metastases are present, ≤ 5 x ULN); Total or
 conjugated bilirubin ≤ 1.5 x ULN

 -  Renal: Serum creatinine ≤ 1.5 x ULN or creatinine clearance (CrCl) ≥ 60 ml/min as
 calculated by the cockcroft-gault method

 -  Coagulation: International Normalized Ratio (INR) ≤ 1.2

 Key Exclusion Criteria:

 -  Known brain metastasis or leptomeningeal disease

 -  Myocardial infarction, symptomatic congestive heart failure (New York Heart
 Association Classification > Class II), unstable angina, or serious uncontrolled
 cardiac arrhythmia within the last 6 months of study Day 1

 -  Major surgery, defined as any surgical procedure that involves general anesthesia and
 a significant incision (ie, larger than what is required for placement of central
 venous access, percutaneous feeding tube, or biopsy) within 28 days of first dose of
 study drug

 -  History of long QT syndrome or whose corrected QT interval (QTc) measured (Fridericia
 method) at screening is prolonged (> 450 ms for males and > 470 ms for females).
 Individuals who screen-fail due to this criterion are not eligible to be re-screened

 -  Clinically significant bleeding within 28 days of study Day 1

 -  Known human immunodeficiency virus (HIV) infection

 -  Hepatitis B surface antigen positive

 -  Hepatitis C virus (HCV) antibody positive

 -  No active anticoagulation within 7 days of study Day 1; including acetylsalicylic
 acid, low molecular weight heparin, or warfarin.

 Note: Other protocol defined Inclusion/Exclusion criteria may apply.