Calcium Dobesilate Versus Coasting for Prevention of Ovarian Hyperstimulation Syndrome
Calcium Dobesilate Versus Coasting for Prevention of Ovarian Hyperstimulation Syndrome
The purpose of this study is to compare the effect of oral Calcium Dobesilate versus costing
 in the prevention of ovarian hyperstimulation syndrome (OHSS) in high-risk women underwent
 intracytoplasmic sperm injection (ICSI).
Two hundred and twenty women at risk of ovarian hyperstimulation syndrome during ICSI cycles
 will be randomly scheduled into two equal groups. In group A, (Calcium Dobesilate group), 1
 cap / 8 hs Doxium ( 500mg) will be given at day of HCG injection and for 3 weeks ; while in
 group B (Coasting group), coasting (withholding gonadotrophins while maintaining pituitary
 suppression) follow up every day by measuring E2 for 3 days then either giving triggering or
 cycle cancellation is done
Inclusion Criteria:

 -  Infertile women undergoing intracytoplasmic sperm injection or polycystic ovarian
 syndrome (PCO) with one of the following:

 -  Presence of more than 20 follicles by ultrasound

 -  E2 more than 3000 pg/ml

 -  Retrieval of more than 15 follicles

 Exclusion Criteria:

 -  None