Sorafenib and Interferon Alfa in Treating Patients With Metastatic or Unresectable Kidney Cancer
Sorafenib and Interferon Alfa in Treating Patients With Metastatic or Unresectable Kidney Cancer
This phase II trial is studying how well giving sorafenib with interferon alfa works in
 treating patients with metastatic or unresectable kidney cancer. Sorafenib may stop the
 growth of tumor cells by blocking some of the enzymes needed for cell growth. Interferon alfa
 may interfere with the growth of tumor cells and slow the growth of kidney cancer. Sorafenib
 may help interferon alfa work better by making tumor cells more sensitive to the drug
PRIMARY OBJECTIVES:

 I. To assess response (confirmed complete and partial responses) of patients with advanced
 renal cell cancer treated with the combination of BAY-43-9006 and interferon alfa-2b.

 SECONDARY OBJECTIVES:

 I. To assess the probability of treatment failure at 6 months and the median overall survival
 of this group of patients.

 II. To evaluate the quantitative and qualitative toxicities of this regimen. III. To
 investigate in a preliminary manner the association of tumor response with measures of
 increased signaling through the Ras-Raf pathway (p-MAPK, p-JNK, p-p38, and p-AKT), with VHL
 gene status, and whether changes in levels of IL-6 and tumor markers of hypoxia including
 PAI-1, VEGF, and osteopontin correspond with clinical outcomes.

 OUTLINE: This is a multicenter study.

 Patients receive oral sorafenib twice daily on days 1-28 and interferon alfa subcutaneously
 on days 1, 3, 5, 8, 10, 12, 15, 17, 19, 22, 24, and 26. Courses repeat every 28 days in the
 absence of disease progression or unacceptable toxicity.

 Patients are followed every 3 months for 1 year and then every 6 months for 2 years.
Inclusion Criteria:

 -  Patients must have histologically or cytologically confirmed renal cell carcinoma
 which is either metastatic (M1) or unresectable (M0); patients must have a component
 of conventional clear cell renal carcinoma; patients with true papillary renal cell
 carcinoma, sarcomatoid features without any clear cell component, chromophobe,
 oncocytoma, collecting duct tumors and transitional cell carcinoma are NOT eligible

 -  Patients must have measurable disease; soft tissue disease, which has been radiated in
 the 2 months prior to registration, is not assessable as measurable disease; X-rays,
 scans, or physical examinations used for tumor measurement must have been completed
 within 28 days prior to registration; X-rays, scans or physical examinations for
 non-measureable disease must have been completed within 42 days prior to registration;
 all disease must be assessed

 -  Patients with metastatic disease who have a resectable primary tumor and are deemed a
 surgical candidate may have undergone resection and have recovered from surgery; at
 least 28 days must have elapsed since surgery and patient must have recovered from any
 adverse effects of surgery

 -  Patients must not have received any prior systemic therapy for renal cell carcinoma,
 including chemotherapy, interferon, interleukin-2, other biologic response modifiers,
 anti-angiogenic therapy, hormonal therapy, or any other experimental systemic therapy;
 prior treatment with thyroid medications is allowed

 -  Patients may have received prior radiation therapy to less than 25% of the bone
 marrow; at least 28 days must have elapsed since completion of prior radiation
 therapy; patients must have recovered from all associated toxicities at the time of
 registration

 -  Total bilirubin =< institutional upper limit of normal

 -  SGOT or SGPT =< 2.5 x institutional upper limit of normal

 -  Serum creatinine =< institutional upper limit of normal or calculated creatinine
 clearance >= 60 mL/min for patients with creatinine levels above institutional normal

 -  Patients who have had a prior nephrectomy must have a serum creatinine =< 2 x
 institutional upper limit of normal

 -  Patients must be offered the opportunity to consent for specimen submission

 -  Patients must have a Zubrod performance status of 0-1

 -  Patients with a history of brain metastases or who currently have treated to untreated
 brain metastases are not eligible; patients with clinical suspicion of brain
 metastases must have a brain CT or MRI negative for metastatic disease obtained within
 56 days prior to registration and must not have any new symptoms since radiographic
 evaluation was done

 -  Any ongoing requirement for systemic corticosteroid therapy is not permitted; topical
 and/or inhaled steroids are allowed

 -  Patients must not be on drugs known to be potent inhibitors of the CYP 3A4 enzyme as
 BAY 43-9006 is at least partially metabolized by this enzyme in the liver; the
 possible effect that inhibitors of this enzyme may have on the metabolism of BAY
 43-9006 is unknown; therefore, patients who are on the following drugs are not
 eligible (patients should not take these drugs while receiving protocol treatment):
 ketoconazole, itraconazole, ritonavir, products containing grapefruit juice,
 cyclosporine, carbamazepine, phenytoin and phenobarbital)

 -  Patients must be able to take oral medication without crushing, dissolving or chewing
 tablets

 -  The effects of BAY 43-9006 on the developing human fetus at the recommended
 therapeutic dose are unknown; for this reason and because raf kinase inhibitor agents
 as well as other therapeutic agents used in this trial are known to be teratogenic,
 patients must not be pregnant or nursing; women/men of reproductive potential must
 have agreed to use an effective contraceptive method (hormonal or barrier method of
 birth control; abstinence) prior to study entry and for the duration of study
 participation; should a woman become pregnant or suspect she is pregnant while
 participating in this study, she should inform her treating physician immediately

 -  No other prior malignancy is allowed except for the following: adequately treated
 basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated
 Stage I or II cancer from which the patient is currently in complete remission, or any
 other cancer from which the patient has been disease-free for 5 years

 -  If Day 28, 42, or 56 falls on a weekend or holiday, the limit may be extended to the
 next working day

 -  All patients must be informed of the investigational nature of this study and must
 sign and give written informed consent in accordance with institutional and federal
 guidelines

 -  At the time of patient registration, the treating institution's name and ID number
 must be provided to the Data Operations Center in Seattle in order to ensure that the
 current (within 365 days) date of institutional review board approval for this study
 has been entered into the database