Sofosbuvir (GS-7977) in Combination With PEG and Ribavirin for 12 Weeks in Treatment Experienced Subjects With Chronic HCV Infection Genotype 2 or 3
Sofosbuvir (GS-7977) in Combination With PEG and Ribavirin for 12 Weeks in Treatment Experienced Subjects With Chronic HCV Infection Genotype 2 or 3
This study is to evaluate the safety, tolerability, and antiviral efficacy of sofosbuvir
 (SOF) in combination with peginterferon alfa 2a (PEG) and ribavirin (RBV) administered for 12
 weeks in participants with chronic genotype 2 or 3 hepatitis C virus (HCV) infection who have
 previously failed prior treatment with an interferon-based regimen.
Inclusion Criteria:

 -  Infection with genotype 2 or 3 HCV infection

 -  Cirrhosis determination

 -  Individual is treatment-experienced

 -  Screening laboratory values within defined thresholds

 -  Individual has not been treated with any investigational drug or device within 30 days
 of the Screening visit

 -  Use of highly effective contraception methods if female of childbearing potential or
 sexually active male

 Exclusion Criteria:

 -  Prior exposure to a direct-acting antiviral drug targeting the HCV NS5B polymerase

 -  Pregnant or nursing female or male with pregnant female partner

 -  Current or prior history of clinical hepatic decompensation

 -  History of clinically-significant illness or any other major medical disorder that may
 interfere with treatment, assessment, or compliance with the study protocol

 -  Excessive alcohol ingestion or significant drug abuse