The Effect of Androgen and Growth Hormone on Height and Learning in Girls With Turner Syndrome
The Effect of Androgen and Growth Hormone on Height and Learning in Girls With Turner Syndrome
The purposes of this study are to learn whether treatment with an androgen type hormone will
 improve the visual-spatial problems associated with Turner syndrome, and to evaluate the
 effect growth hormone, with and without androgen, has on growth.
Turner syndrome is associated with short stature, multiple physical stigmata, absent pubertal
 development, and increased learning problems. This study is designed to (1) examine the
 effects of sex steroids (androgen and estrogen) on multiple variables including growth rate,
 GH binding protein, IGF-I, IGFBP3, and cognitive function in the setting of supplemental
 growth hormone administration and (2) to investigate any synergistic or additive effects of
 the androgen and estrogen combination versus each alone, on the above variables.
-  Karyotype diagnosis compatible with Turner syndrome, but no presence of any Y material
 in the peripheral karyotype unless a gonadectomy has been performed;

 -  Chronological age between 10.0 and 14.9 years;

 -  Bone age less than or equal to 12 years; and

 -  No treatment with estrogen, androgen, growth hormone, or any other growth-promoting
 agents exceeding 12 months, and no treatment with any of these agents in the previous
 3 months.