Chronic Pain and Vitamin D
Chronic Pain and Vitamin D
Non-systematized chronic musculoskeletal pains are a frequent reason for consulting in
 general practice. The possible causes are numerous and sometimes nonspecific. In some cases,
 the etiologic investigation of patients with non-systematized and chronic musculoskeletal
 pain can not highlight any organic cause. Several studies have shown a link between these
 symptoms and vitamin D deficiency, characterized by a blood level of 25 (OH) vitamin D <
 20.8ng/ml. This deficit is easy to identify and to correct through proper vitamin D
 supplementation with few side effects. Nevertheless, it remains unknown and vitamin D
 deficiency is rarely considered as a possible etiology in patients with chronic pain. We
 hypothesize that vitamin D supplementation in patients with non-systematized musculoskeletal
 pain and deficient in vitamin D could improve painful symptoms. We aim to perform a
 double-blind randomized controlled trial, vitamin D versus placebo, to assess the pain
 improvement after vitamin D supplementation.
Inclusion Criteria:

 -  Women and men

 -  Aged 18-50 years (included)

 -  Consulting their general practitioner

 -  With chronic and diffuse musculoskeletal pain, without known etiology, lasting for at
 least 3 months

 -  With a 25(OH)vitamin D deficiency <20.8 ng/ml (52 nmol/l) at inclusion

 -  Who signed the consent form

 Exclusion Criteria:

 -  Identifiable source of pain requiring an appropriate specific management

 -  Disease or treatment that may interfere with the metabolism of vitamin D

 -  Current or previous hypercalcemia or hypercalciuria, treatment with digitalics and
 patients with history of nephrolithiasis

 -  Current treatment with vitamin D or at least one vitamin D vial taken over the
 previous 6 months

 -  Pregnancy or breastfeeding

 -  not affiliated to a social security system

 -  Refusal or inability to give consent