The SNORES Randomized Clinical Trial
The SNORES Randomized Clinical Trial
Randomized clinical trial among women with polycystic ovary syndrome (PCOS) who present for
 fertility treatment to evaluate the impact of screening for obstructive sleep apnea.
The investigators' goal is to perform a randomized clinical trial among women with PCOS who
 present for infertility treatment. Our primary outcome is to determine if screening women
 with PCOS, and treating those with confirmed sleep apnea, will lead to more ovulatory cycles.
 Our sub-aims are to describe the rate of OSA and sleep symptoms in patients with PCOS, to see
 if current sleep questionnaires correlate to a diagnostic sleep study, to describe the
 correlation between OSA and biomarkers of glucose homeostasis in women with PCOS, to
 investigate health related quality of life between the groups, to compare perinatal outcomes
 between the groups, and to evaluate the composition of breastmilk among women who choose to
 breastfeed.
Inclusion Criteria

 -  Females 18 - 50 years old.

 -  Receiving care from an Obstetrician / gynecologist or a Reproductive endocrinology
 infertility specialist

 -  Polycystic ovarian syndrome defined by the modified Rotterdam criteria

 -  Able to speak and understand as well as give informed consent in English

 Exclusion Criteria

 -  Late onset congenital adrenal hyperplasia

 -  Cushings disease

 -  Androgen-secreting tumors

 -  Previous diagnosis of obstructive sleep apnea

 -  Current use of over the counter or prescribed sleep medications.

 -  Examples of medications that exclude a patient from this study include but are
 not limited to Unisom, Ambien or Lunesta.

 -  Patients who are taking non-prescribed herbal medications for sleep will not be
 excluded from the study. Examples of these include but are not limited to
 melatonin, chamomile, or valerian.

 -  Untreated thyroid disease

 -  Prolactin excess

 -  Patients with the following medical conditions will be excluded from the study as
 portable sleep apnea monitors are not indicated in patients with severe pulmonary
 disease, neuromuscular disease, or congestive heart failure.