Oral Contraceptive During Menopausal Transition
Oral Contraceptive During Menopausal Transition
Muscle or joint pain is one of the most common symptoms during menopausal transition. As this
 could be severe enough to affect social and daily life and to reduce quality of life,
 attentions should be paid about this.

 Although understanding of muscle or joint pain related to menopause is still insufficient,
 estrogen can play an important role. Previous studies have shown that estrogen protects
 cartilage in both animals and humans.

 However, perimenopause is different from postmenopause, in the point that estrogen is still
 secreted with a great fluctuation.

 Until now, no study has been performed to evaluate the effects of oral contraceptive on
 muscle or joint pain in women during menopausal transition. Moreover, since menopausal
 symptoms vary according to ethnicity and culture, a study in Korean population is necessary.

 Therefore, this randomized controlled trial was designed to evaluate the effects of oral
 contraceptive on muscle or joint pain in women during menopausal transition, compared to
 NSAID (non-steroidal anti-inflammatory drug).
Inclusion Criteria:

 -  Perimenopausal women aged 45 or more

 -  Women who have multiple joint or muscle pain for at least 3 months (at least two sites
 out of upper and lower extremities or axial)

 Exclusion Criteria:

 -  Rheumatoid arthritis, ankylosing spondylitis, rheumatic polymyalgia, Inflammatory
 myopathy

 -  pregnancy

 -  History of hysterectomy or bilateral oophorectomy

 -  Vasomotor symptoms

 -  History of surgery of musculoskeletal system

 -  History of cancer

 -  Abnormalities of thyroid function

 -  Focal neurologic deficit

 -  Smoking within 1 year

 -  Uncontrolled hypertension

 -  Coronary heart disease

 -  Diabetes mellitus

 -  Stoke

 -  Active thromboembolism

 -  Undiagnosed vaginal bleeding

 -  Acute hepatic dysfunction

 -  Gastrointestinal ulcer

 -  Severe renal dysfunction

 -  Hypersensitivity to drugs

 -  Current hormone user or past users within 3 months