Effect of NMN Supplementation on Organ System Biology
Effect of NMN Supplementation on Organ System Biology
The goal of this proposal is to determine whether the beneficial effects of NMN on metabolic
 function observed in rodents applies to people.
This study is looking at the effect of the dietary supplement "Nicotinamide mononucleotide"
 (NMN) on key cardiovascular and metabolic functions, specifically those that are important
 risk factors for diabetes and cardiovascular disease.
Inclusion Criteria:

 -  BMI 25.0-34.9 kg/m²

 -  Prediabetes defined as a 2-h oral glucose tolerance test plasma glucose of 140-199
 mg/dL with or without a fasting plasma glucose of 100-125 mg/dL, or HbA1C ≥5.7.

 Exclusion Criteria:

 -  Women who are still having menses

 -  Persons who take niacin, nicotinamide, or other vitamin B3-related supplementation and
 are not willing to discontinue supplementation for 3 weeks before medical screening
 and during the entire study period

 -  Persons who consume moderate-large amounts of caffeine daily (>2 cups of coffee or 8
 oz caffeinated drinks per day) or consume less amounts of caffeine but believe
 withdrawal symptoms (e.g. headache) are likely if caffeine is stopped

 -  Unstable weight (>3% change during the last 2 months before entering the study)