Cluster Headache and SPINK-1 Gene
Cluster Headache and SPINK-1 Gene
Cluster headache (CH) is a rare, excruciating primary headache disorder. A genetic basis has
 been suggested by family and twin studies, but the mode of transmission seems to vary and the
 amount of heritability is unclear.

 The number of genetic association studies investigating variants implicated in the
 pathophysiology of CH is limited. The HCRTR2 1246G > A and the ADH4 925A > G polymorphisms
 have been associated with CH. The former has been confirmed and may affect the hypothalamic
 hypocretin system. The aim of the present study was to investigate the possible link between
 SPINK 1 gene and cluster headache.
Inclusion Criteria:

 -  People aged 18 or over

 -  Patient consulting in Marseille's or Nice's Pain departments

 -  Patient agreeing to participate to the research study

 -  Patient with health insurance

 Exclusion Criteria:

 -  People aged under 18

 -  Patient refusing to participate to the research study

 -  Patient with deprivation of liberty