Clinical Outcome of Patients With Low-gradient Severe Aortic Stenosis
Clinical Outcome of Patients With Low-gradient Severe Aortic Stenosis
To assess the ability of baseline clinical parameters and imaging modalities to predict short
 and long term left ventricular function and clinical outcome of subjects with low-gradient,
 severe aortic stenosis.

 To assess the impact of aortic valve replacement as compared to medical therapy on clinical
 outcome of patients with low-gradient, severe aortic stenosis.

 To assess possible impact of aortic annulus assessment using 3-dimensional imaging modalities
 on the assessment of AS severity and definition of low gradient severe aortic stenosis.
To assess the ability of baseline clinical parameters and imaging modalities to predict short
 and long term left ventricular function and clinical outcome of subjects with impaired left
 ventricular function and / or low-gradient, severe aortic stenosis.

 To assess the impact of aortic valve replacement as compared to medical therapy on clinical
 outcome of patients with impaired left ventricular function and / or low-gradient, severe
 aortic stenosis.

 To assess possible impact of aortic annulus assessment using 3-dimensional imaging modalities
 on the assessment of AS severity and definition of low gradient severe aortic stenosis.
Inclusion Criteria:

 1. Severe aortic stenosis defined as aortic valve area of less than 1 cm2 or index area
 of 0.6 cm2/m2 and low gradient (mean gradient across the aortic valve <40 mmHg) by
 echocardiography

 2. Symptomatic patients with aortic stenosis referred for medically indicated AVR

 3. Signed informed consent to participate in the study.

 Exclusion Criteria:

 1. Pregnancy or breast feeding (women of childbearing potential will have a serum or
 urine pregnancy test).

 2. Need for emergency surgery for any reason.

 3. Any case in which the practicing physician asserts that enrollment in the protocol
 will adversely affect the patient treatment course.