Comparison of Purified Vero Rabies Vaccine, Serum Free With Human Diploid Cell Vaccine in Pre-exposure Use
Comparison of Purified Vero Rabies Vaccine, Serum Free With Human Diploid Cell Vaccine in Pre-exposure Use
The aim of this study is to generate data on immunogenicity and safety of Purified Vero
 Rabies Vaccine - Serum Free (VRVg) in comparison with Imovax® Rabies in order to support the
 registration of VRVg in the USA.

 Primary Objectives:

 -  To demonstrate that VRVg is non inferior to Imovax® Rabies in terms of proportion of
 subjects achieving an rabies virus neutralizing antibody (RVNA) titer ≥ 0.5 IU/mL at Day
 42.

 -  To demonstrate that the observed proportion of subjects achieving an RVNA titer ≥ 0.5
 IU/mL at Day 42 is at least 99%, with a 95% lower confidence limit of at least 97%.

 Secondary Objectives:

 -  To assess the clinical safety of VRVg each vaccine after each vaccine injection when
 administered in a pre-exposure schedule.

 -  To describe the immune response induced by each vaccine 21 days after two vaccinations
 (Day 28) in a randomized subset of subjects and 14 days after the last vaccination of
 the primary vaccination series.

 -  To describe antibody persistence at 6 and 12 months after the first vaccination in all
 subjects, and at 18 and 24 months in a subset of subjects.
The vaccination will be given in three injections, at Day 0, Day 7, and Day 28, respectively,
 based on the Advisory Committee on Immunization Practice (ACIP) and the World Health
 Organization (WHO) recommendations for pre-exposure regimen. A booster dose will be
 administered 1 year after the first vaccine injection in a randomized subset of participants.

 Safety will be assessed in all participants up to 28 days after vaccination, as applicable,
 in terms of occurrence of adverse events (AEs), and serious adverse events (SAEs) and adverse
 events of special interest (AESIs) up to Month 12.
Inclusion Criteria:

 -  Aged 18 to < 65 years on the day of inclusion

 -  Informed consent form has been signed and dated

 -  Able to attend all scheduled visits and comply with all trial procedures.

 Exclusion Criteria:

 -  Subject is pregnant, or lactating, or of childbearing potential (to be considered of
 non-childbearing potential, a female must be post-menopausal for at least 1 year,
 surgically sterile, or using an effective method of contraception or abstinence from
 at least 4 weeks prior to the first vaccination and until at least 4 weeks after last
 vaccination)

 -  Participation at the time of study enrollment (or in the 4 weeks preceding the first
 trial vaccination)or planned participation during the present trial period in another
 clinical trial investigating a vaccine, drug, medical device, or medical procedure

 -  Receipt of any vaccine in the 4 weeks preceding the first trial vaccination or planned
 receipt of any vaccine in the 4 weeks following any trial vaccination

 -  Previous vaccination against rabies (in pre- or post-exposure regimen) with either the
 trial vaccine or another vaccine

 -  Receipt of immune globulins, blood or blood-derived products in the past 3 months

 -  Known or suspected congenital or acquired immunodeficiency; or receipt of
 immunosuppressive therapy such as anti-cancer chemotherapy or radiation therapy within
 the preceding 6 months; or long-term systemic corticosteroid therapy (prednisone or
 equivalent for more than 2 consecutive weeks within the past 3 months)

 -  Self-reported seropositivity for Human Immunodeficiency Virus (HIV), Hepatitis B, or
 Hepatitis C

 -  At high risk for rabies exposure during the trial

 -  Known systemic hypersensitivity to any of the vaccine components, or history of a
 life-threatening reaction to a vaccine containing any of the same substances as the
 vaccines used in the study

 -  Self-reported thrombocytopenia, contraindicating intra muscular (IM) vaccination

 -  Bleeding disorder, or receipt of anticoagulants in the 3 weeks preceding inclusion,
 contraindicating IM vaccination

 -  Deprived of freedom by an administrative or court order, or in an emergency setting,
 or hospitalized involuntarily

 -  Current alcohol abuse or drug addiction that might interfere with the ability to
 comply with trial procedures

 -  Chronic illness that, in the opinion of the investigator, is at a stage where it might
 interfere with trial conduct or completion

 -  Moderate or severe acute illness/infection (according to investigator judgment) on the
 day of vaccination or febrile illness (temperature ≥ 100.4°F). A prospective subject
 should not be included in the study until the condition has resolved or the febrile
 event has subsided

 -  Identified as an Investigator or employee of the Investigator or study center with
 direct involvement in the proposed study, or identified as an immediate family member
 (i.e., parent, spouse, natural or adopted child) of the Investigator or employee with
 direct involvement in the proposed study

 -  History of Guillain-Barré Syndrome.