Cediranib Maleate and Combination Chemotherapy in Treating Patients With Advanced Biliary Cancers
Cediranib Maleate and Combination Chemotherapy in Treating Patients With Advanced Biliary Cancers
This phase II trial is studying how well giving cediranib maleate together with combination
 chemotherapy works in treating patients with advanced biliary cancers. Cediranib maleate may
 stop the growth of tumor cells by blocking some of the enzymes needed for cell growth or by
 blocking blood flow to the tumor. Drugs used in chemotherapy, such as oxaliplatin, leucovorin
 calcium, and fluorouracil, work in different ways to stop the growth of tumor cells, either
 by killing the cells or by stopping them from dividing. Giving cediranib maleate together
 with combination chemotherapy may kill more tumor cells.
PRIMARY OBJECTIVES:

 I. To determine the response rate to AZD2171 (cediranib maleate) and modified folinic
 acid-fluorouracil-oxaliplatin-6 regimen (FOLFOX 6) in subjects with advanced biliary cancers.

 SECONDARY OBJECTIVES:

 I. To determine overall assessment of toxicity of AZD2171 and modified FOLFOX6. II. To
 determine the progression-free survival of subjects with advanced biliary cancers treated
 with AZD2171 and modified FOLFOX6.

 III. To determine overall survival of subjects with advanced biliary cancers treated with
 AZD2171 and modified FOLFOX6.

 OUTLINE:

 Patients receive cediranib maleate orally (PO) once daily (QD) on days 1-14 and modified
 FOLFOX6 comprising oxaliplatin intravenously (IV) over 2 hours, leucovorin calcium IV over 2
 hours, and fluorouracil IV over 46 hours on day 1. Courses repeat every 14 days in the
 absence of disease progression or unacceptable toxicity.

 After completion of study treatment, patients are followed up every 3 months for 1 year,
 every 6 months for 2 years, and then annually thereafter.
Inclusion Criteria:

 -  Patients with histopathological or cytopathological diagnosis of advanced biliary
 carcinoma (gallbladder cancer, cholangiocarcinoma, ampullary cancer) not amenable to
 conventional surgical approach are eligible

 -  Patients must have measurable disease, defined as at least one lesion that can be
 accurately measured in at least one dimension (longest diameter to be recorded) as >
 20 mm with conventional techniques or as > 10 mm with spiral CT scan

 -  No patients with untreated brain metastases

 -  Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2 (Karnofsky ≥ 60%)

 -  Life expectancy of greater than 12 weeks

 -  White blood cell (WBC)/leukocytes ≥ 3,000/μL

 -  Absolute neutrophil count ≥ 1,500/μL

 -  Platelets ≥ 100,000/μL

 -  Hemoglobin ≥ 9 g/dL

 -  Total bilirubin ≤ 3 mg/dL

 -  Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase
 [SGOT])/alanine aminotransferase (ALT) (serum glutamic pyruvate transaminase [SGPT]) ≤
 2.5 times institutional upper limit of normal

 -  Creatinine within normal institutional limits OR calculated creatinine clearance ≥ 60
 mL/min

 -  No patients with proteinuria not meeting the criteria below; urine sample must be
 tested by urine protein:creatinine (UPC) ratio or by urinalysis method within 1 week
 of starting study treatment; depending upon the testing method used, the following
 criteria must be met:

 -  UPC ratio must be < 1.0; if UPC ratio is ≥ 1.0, a 24-hour urine specimen must be
 collected and must demonstrate < 1 g of protein

 -  Urinalysis must indicate 0-1+ protein; if urinalysis reading is ≥ 2+, a 24-hour
 urine specimen must be collected and must demonstrate < 1 g of protein

 -  Not pregnant or nursing

 -  Negative pregnancy test

 -  Fertile patients must use adequate contraception (hormonal or barrier method of birth
 control; abstinence) before and during study treatment

 -  Acceptable contraception includes abstinence, oral contraceptives, intra-uterine
 device (IUD), diaphragm, Norplant, approved hormone injections, condoms, or
 documentation of medical sterilization

 -  Patients with evidence of heart disease must be New York Heart Association (NYHA)
 Class I or II

 -  NYHA Class II patients controlled with treatment are considered at increased risk
 for compromised left ventricular ejection fraction (LVEF) and will undergo
 increased cardiac monitoring

 -  No patients with other active invasive cancers except nonmelanoma skin cancer or
 carcinoma in-situ of the cervix

 -  History of prior cancer is allowed as long as there has been no evidence of
 disease within the past 5 years

 -  No patients with mean corrected QT interval (QTc) > 480 msec (with Bazett's
 correction) in screening electrocardiogram or history of familial long QT syndrome

 -  No patients with uncontrolled hypertension defined as systolic blood pressure (BP) ≥
 140 mm Hg or diastolic BP ≥ 90 mm Hg, with or without anti-hypertensive medication or
 history of hypertensive crisis or hypertensive encephalopathy

 -  Patients with initial BP elevations are eligible once their BP is controlled to
 above parameters

 -  No patients with uncontrolled intercurrent illness including, but not limited to:

 -  Hypertension (> 140/90 mm Hg)

 -  Chronic or active infection requiring chronic suppressive antibiotics

 -  History of or symptomatic congestive heart failure requiring chronic medical
 therapy

 -  NYHA class III or IV heart disease

 -  Unstable angina pectoris within 180 days prior to starting study treatment

 -  Myocardial infarction within 180 days prior to study treatment

 -  Gastroduodenal ulcer(s) determined by endoscopy to be active within 180 days
 prior to study treatment

 -  Serious or non-healing wound, skin ulcers, or bone fracture

 -  Any significant bleeding that is not related to the primary tumor within 180 days
 prior to study treatment

 -  Known bleeding diathesis or coagulopathy

 -  Paresthesias, peripheral sensory neuropathy > gr. 1 per Common Terminology
 Criteria for Adverse Events (CTCAE) v.4, or peripheral motor neuropathy ≥ gr. 2
 per CTCAE v.4

 -  Psychiatric illness/social situations that would limit compliance with study
 requirements

 -  No patients with history of transient ischemic attack (TIA) or cerebrovascular
 accident (CVA) within 180 days prior to study treatment, symptomatic peripheral
 ischemia; history of arterial thrombotic event within 180 days prior to study
 treatment; gastrointestinal (GI) perforation within 180 days prior to study treatment

 -  Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral
 therapy are ineligible

 -  Patients who are chemotherapy naive unless chemotherapy was given as adjuvant
 post-surgical treatment and at least 6 months have elapsed since adjuvant chemotherapy

 -  No patients who have had major surgical procedures, open biopsies, or significant
 traumatic injury within 28 days prior to study treatment

 -  Chemotherapy for prior cancer is permitted

 -  Eligibility of patients receiving any medications or substances known to affect or
 with the potential to affect the activity or PK of AZD2171 will be determined
 following review of their case by the Principal Investigator

 -  Efforts should be made to switch patients with brain metastases who are taking
 enzyme-inducing anticonvulsant agents to other medications

 -  Patients may not be receiving any other investigational agents nor have participated
 in an investigational trial within the past 30 days

 -  Patients may not be receiving any medication that may markedly affect renal function
 (e.g., vancomycin, amphotericin, pentamidine)

 -  Patients may not be receiving therapeutic doses of Coumadin or equivalent

 -  No patients requiring drugs with proarrhythmic potential