HVPG-Guided Therapy Versus EVL Plus NSBB in Second Prophylaxis of Esophageal Variceal Bleeding
HVPG-Guided Therapy Versus EVL Plus NSBB in Second Prophylaxis of Esophageal Variceal Bleeding
A single-center randomized controlled study comparing endoscopic or interventional therapy
 guided by the hepatic venous pressure gradient (HVPG) , to standard endosopic variceal
 ligation plus nonselective beta-blocker therapy (NSBB) in patients with esophageal varices
 due to liver cirrhosis with a history of esophageal variceal hemorrhage.Primary study outcome
 of the study is variceal rebleeding episodes occurring within the first years after
 interventions. Second study outcomes of the study are hepatic encephalopathy occurrence,
 mortality occurrence, liver transplantation or other cirrhosis-related complications.
Inclusion Criteria:

 -  Liver cirrhosis diagnosed by clinical examination, imaging or biopsy;

 -  A previous history of variceal hemorrhage;

 -  Written informed consent.

 Exclusion Criteria:

 -  Previous history of secondary prophylactic treatment;

 -  Contraindications to treatment of endoscopy, surgery and TIPS

 -  Severe cardiac, pulmonary or renal dysfunction;

 -  Lactating or pregnant;

 -  Malignancies;