Prevalence and Predictors of Depression in COPD
Prevalence and Predictors of Depression in COPD
Depression adversely affects quality of life in COPD patients, associated with higher rate of
 exacerbations, admissions and mortality. However, local prevalence rate of depression in
 geriatric COPD patients remains unknown.

 Though BODE index is superior to FEV1 in prediction of depression in COPD, it is unclear
 which domain of BODE correlates best with depression. Furthermore, with multiple confounding
 factors, it's ambiguous that whether frequent exacerbation is an 'independent' predictor for
 depression among COPD patients.

 The objective of this study is i.) to study the local prevalence rate of depression in
 geriatric COPD patients, ii.) to identify risk factors for depression especially looking at
 the any independent relationship between frequent exacerbations, various domains of BODE
 index and depression.
This study is a multi-centers, cross-sectional study, conducted in Kwong Wah Hospital and
 Wong Tai Sin Hospital, Hong Kong SAR. Age and comorbidity-matched COPD and control subjects
 were recruited from clinics. Depressive symptoms were measured by a validated Chinese version
 of Geriatric Depression Scale short form (GDS - 15 items) with 2 cut-off points. A score of 8
 or above was considered significant depressive symptoms while the cut off score of 5 or above
 was for patients with mild depressive symptoms. Prevalence rates of depressive symptoms were
 measured in both COPD and control groups. Predictors for depression (GDS = or> 8) were
 determined using univariate and multivariate analysis.
Inclusion Criteria:

 -  aged 60 or above,

 -  with stable COPD suggested clinically and

 -  post-bronchodilator spirometry FEV1/FVC ratio <0.7.

 Exclusion Criteria:

 -  Patients were excluded if they had co-existing pulmonary diseases like active
 pulmonary tuberculosis, interstitial lung diseases etc;

 -  if they were too demented or physically incapacitated to participate e.g
 wheelchair-bound for bedbound.