Epidemiology of Inflammatory Bowel Disease in the Songpa-Kangdong District, Seoul, Korea.
Epidemiology of Inflammatory Bowel Disease in the Songpa-Kangdong District, Seoul, Korea.
The purpose of this study is to evaluate the incidence, prevalence, clinical characteristics
 and prognosis of Crohn's disease and ulcerative colitis over time in a district of Seoul,
 Korea.
Inflammatory bowel disease (IBD), which is comprised of Crohn's disease (CD) and ulcerative
 colitis (UC) is a chronic inflammatory disease of gut with uncertain etiopathogenesis.
 According to our previous study (Yang, et al. Inflamm Bowel Dis 2008; 14: 542-549), the
 incidence and prevalence of IBD in Korea are still low compared with those in Western
 countries, but are rapidly increasing. However, the long-term trends of epidemiology of CD
 and UC together with their characteristics and prognosis in Korea are uncertain yet. The
 investigators therefore aim to elucidate the incidence and prevalence of CD and UC over a
 30-year period, from 1986 to 2017, in the Songpa-Kangdong district of Seoul, Korea. In
 addition, the investigators also aim to reveal the clinical features at the time of diagnosis
 of IBD, long-term evolution of disease and prognosis.
Inclusion Criteria:

 -  Definite cases of CD and UC

 Patients are diagnosed with CD if they meet at least 2 of the following criteria:

 1. clinical history of abdominal pain, weight loss, malaise, diarrhea, and/or rectal
 bleeding

 2. endoscopic findings of mucosal cobblestoning, linear ulceration, skip areas, or
 perianal disease

 3. radiologic findings of stricture, fistula, mucosal cobblestoning, or ulceration

 4. macroscopic appearance of bowel wall induration, mesenteric lymphadenopathy, and
 "creeping fat" at laparotomy

 5. pathologic findings of transmural inflammation and/or epithelioid granulomas

 Only patients who meet these criteria for at least 2 months are included.

 Patients are diagnosed with UC only if all 3 of the following criteria are present

 1. a typical history of diarrhea or blood and pus or both in the stool for longer than 4
 weeks

 2. a typical sigmoidoscopic or colonoscopic picture with diffusely granular, friable, or
 ulcerated mucosa without rectal sparing or skip lesions or radiological signs of
 characteristic continuous granular or ulcerated mucosa

 3. characteristic histopathological signs of inflammation on biopsy

 Exclusion Criteria:

 -  IBD unclassified

 -  Ethnic groups other than Korean