Post-Traumatic Stress Symptoms (PTSS) in Transplant Recipients
Post-Traumatic Stress Symptoms (PTSS) in Transplant Recipients
This study is conducted to better understand Post-Traumatic Stress Symptoms (PTSS) in
 adolescent transplant recipients and their parent/guardian and to see if PTSS play a role in
 the way adolescent transplant recipients take their prescribed medicine.

 Target population: medically stable adolescent solid organ (e.g., heart, kidney, liver, lung,
 small bowel) transplant recipients and their parent(s)/guardian.
Inclusion Criteria:

 The patient:

 -  and/or their parent(s)/guardian must be able to understand and provide informed
 consent in English or Spanish;

 -  is prescribed tacrolimus (either brand or generic formulation); and

 -  has been seen in the enrolling center's clinic at least twice in the last two years.

 Exclusion Criteria:

 The patient:

 -  received a transplant less than 18 months prior to enrollment;

 -  has had more than one transplant (including marrow replacement);

 -  or their parent(s)/guardian is actively psychotic or severely disoriented due to any
 cause, including hepatic encephalopathy (temporary exclusion);

 -  or their parent(s)/guardian has been diagnosed with severe intellectual disability as
 defined in the Diagnostic and Statistical Manual of Mental Disorders, 5th edition
 (DSM-5);

 -  is not medically stable or is hospitalized;

 -  is currently enrolled in a study that aims to improve adherence to medical
 recommendations;

 -  is receiving cognitive behavioral therapy for confirmed or suspected diagnosis of
 Post-Traumatic Stress Disorder (PTSD) at enrollment;

 -  is receiving psychotropic medications for a confirmed or suspected diagnosis of PTSD.