Effects of Hyperthermic Baths on Motor Symptoms of Parkinson's Disease
Effects of Hyperthermic Baths on Motor Symptoms of Parkinson's Disease
The aim of this study is to further evaluate the effects of seasonal variation and the
 aquatic thermal environment of hyperthermic baths (HTB) on the Motor Symptoms (MS) of
 Parkinson's Disease (PD), and whether the environmental temperature is associated with these
 effects.
After being informed about the study and potential risks, all participants will give written
 informed consent. All participants who meet the inclusion criteria will undergo a complete
 history and physical examination, including an assessment using the Movement Disorder
 Society-United Parkinson's Disease Rating Scale (MDS-UPDRS), H&Y stage, MMSE and MOCA. Each
 participant will receive two subjective measures (the Movement Disorder Society-United
 Parkinson's Disease Rating Scale part III motor examination total scores and the modified
 Webster Symptoms Score) nine times in an open medication state (open state). Each participant
 will take hyperthermic baths (HTB) at the same time on the first, third and fifth days. The
 participants will receive subjective measures before and after the HTB. The time at which the
 subjective measures begin after the HTB will be recorded. In the second week, no participants
 accept any intervention. To avoid the effects of fluctuations in dopaminergic drugs
 concentrations, subjective measures will be given without HTB at the recorded times on the
 fifteenth, seventeenth and nineteenth days.
Inclusion Criteria:

 -  ≥ 18 years of age

 -  Diagnosis of Idiopathic Parkinson's Disease（IPD）based on the Movement Disorder Society
 clinical diagnostic criteria for Parkinson's Disease

 -  Subjective feeling that Motor Symptoms（MS）of Parkinson's Disease （PD） were affected by
 seasonal variation (i.e., MS were more severe in winter than in summer) and improved
 after HTB

 -  No change in the patient's PD medication regimen during the study

 Exclusion Criteria:

 -  Symptomatic bradycardia, severe postural hypotension, symptomatic coronary
 insufficiency, severe organic heart damage, severe cerebrovascular disease, and active
 psychosis

 -  Dementia (Mini-Mental State Examination (MMSE) < 24 and Montreal Cognitive Assessment
 (MOCA) < 26)

 -  Failure to cooperate with the study requirements and poor compliance