A Study of AbGn-107 in Patients With Gastric, Colorectal, Pancreatic or Biliary Cancer
A Study of AbGn-107 in Patients With Gastric, Colorectal, Pancreatic or Biliary Cancer
This study is to define the safety profile and to determine the Maximal tolerated dose
 regimen and preliminary efficacy of AbGn-107 administered every 14 days (Q2W regimen) or 28
 days (Q4W regimen) in patients with chemo-refractory locally advanced, recurrent or
 metastatic gastric, colorectal, pancreatic or biliary cancer.
AbGn-107 is an antibody drug conjugate (ADC) which targets an antigen (AG7 antigen) present
 in gastric, colorectal, pancreatic cancer or biliary cancer. This study is a standard 3 + 3
 dose escalation design with cohort expansion. AbGn-107 will be administered every 14 days
 (Q2W regimen) or 28 days (Q4W regimen) in patients with chemo-refractory locally advanced,
 recurrent or metastatic gastric, colorectal, pancreatic adenocarcinoma or biliary cancer. The
 primary objectives of this study are to define the safety profile and to determine the
 maximum tolerated dose regimen of AbGn-107, and the secondary objectives are to evaluate the
 pharmacokinetic (PK) parameters, the immunogenicity, and preliminary efficacy of AbGn-107.
Inclusion Criteria:

 1. Age ≥18 years. A patient may be of either sex and of any race/ethnicity.

 2. Histologically confirmed, chemo-refractory, locally advanced, recurrent or metastatic
 gastric (including GE junction), colorectal, or pancreatic adenocarcinoma or biliary
 cancer (including cholangiocarcinoma, gallbladder and ampullary carcinomas).

 1. Patient must not have curative options available (e.g. a single metastatic focus
 in the liver in a patient with MCRC eligible for metastasectomy).

 2. Chemo-refractory is defined as:

 -  Progression on or following, or intolerant of, at least one prior line of
 standard systemic therapy for advanced or metastatic gastric or pancreatic
 or biliary cancers.

 -  Progression on or following, or intolerant of, at least two prior lines of
 standard systemic therapy for advanced or metastatic colorectal cancers.

 -  Patients who have progressed/recurred following neoadjuvant/adjuvant
 chemotherapy for earlier stage disease, if completed within the previous 6
 months, are eligible.

 3. Archived tissue must be available for all patients (both dose escalation and expansion
 cohorts). Dose Escalation Only-If tissue is not available, patients may still be
 considered eligible for enrollment, if all other eligibility criteria are confirmed
 and after discussion with and approval by the sponsor medical monitor. Cohort
 Expansion Only-Tissue must be to confirmed high expression of AG7 antigen during the
 Pre-Screening period, defined as immune reactive score (IRS) ≥8, via slides from
 original diagnostic biopsy material or biopsy of recurrent/metastatic disease, prior
 to enrollment.

 4. Measurable disease by RECIST 1.1 criteria

 5. Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0-1.

 6. Adequate organ function within 3 weeks prior to first study drug administration as
 evidenced by:

 1. Absolute neutrophil count ≥1.5 x 10^9/L,

 2. Hemoglobin ≥9 g/dL,

 3. Platelet count ≥100 x 10^9/L,

 4. Serum creatinine ≤1.5 x upper limit of normal (ULN) or a calculated creatinine
 clearance >60 mL/min,

 5. Total bilirubin <1.5 x ULN, except for patients with Gilbert's disease who are
 eligible if total bilirubin ≤ 3 mg/dL.

 6. Aspartate aminotransferase (AST)/serum glutamic-oxalacetic transaminase (SGOT)
 and alanine aminotransferase (ALT)/serum glutamic-pyruvic transaminase (SGPT)
 <2.5 x ULN, or, in the presence of documented liver metastases, ≤5 x ULN.

 7. Ability to adhere to dose and visit schedules.

 8. Women of childbearing potential (WOCP) must have a negative pregnancy test result
 prior to enrollment. WOCP and men whose partners are WOCP must agree to use a highly
 effective method of birth control during the study and for 6 months following the last
 dose of study drug. A highly effective method of birth control is defined as one which
 results in a low failure rate (less than 1% per year).

 9. Ability to provide written informed consent

 10. Life expectancy of at least 3 months.

 Exclusion Criteria:

 1. Any persistent, unresolved Common Terminology Criteria for Adverse Events (CTCAE)
 Grade ≥2 drug-related toxicity (except alopecia, erectile impotence, tinnitus, hot
 flashes, and loss of libido) associated with previous treatment. Inclusion of patients
 with persistent neuropathy or hearing loss Grade ≥2 due to previous treatment requires
 discussion with the sponsor.

 2. Radiation therapy within 2 weeks prior to first study drug administration.

 3. Major surgery within 3 weeks prior to first study drug administration.

 4. Any chemotherapy within 30 days of enrollment.

 5. Participation in any other clinical study with a potentially therapeutic agent or
 receipt of another investigational product within 21 days or 5 plasma half-lives,
 whichever is longer, prior to first day of drug administration (Day 1).

 6. Active central nervous system metastases. Patients with a history of brain metastases
 may be eligible, provided they have been definitively treated and are clinically
 stable, after discussion with sponsor. Treated or untreated leptomeningeal disease is
 not permitted.

 7. Known human immunodeficiency virus (HIV) infection or a known HIV-related malignancy.
 Note: HIV testing is not required unless there is any clinical suspicion that the
 patient might be HIV positive.

 8. Known active hepatitis B or C. HBV and HCV tests are required prior to Day 1.

 9. Any clinically significant condition or situation, other than the condition being
 studied that, in the opinion of the investigator, would impair with their ability to
 receive or tolerate the planned treatment, or interfere with the study evaluations or
 optimal participation in the study.

 10. Pregnancy or breastfeeding.