The Effect of D3 on Selected Cytokines Involved in Cytokine Storm in the Covid-19 Uninfected Jordanian People
The Effect of D3 on Selected Cytokines Involved in Cytokine Storm in the Covid-19 Uninfected Jordanian People
The effect of Weekly 50,000 IU vitamin D3 supplements on the serum levels of selected
 cytokines involved in cytokine storm of Covid-19; A randomized clinical trial in the Covid-19
 uninfected people with vitamin D deficiency.
No data are available on the effect of Weekly 50,000 IU vitamin D3 supplements on the serum
 levels of selected cytokines involved in cytokine storm of Covid-19 in the Covid-19
 uninfected Jordanian people with vitamin D deficiency. This study was designed to investigate
 whether a high dose of vitamin D3 (50,000 IU) / week for 8 weeks supplementation has a
 potential effect on cytokine storm of Covid-19; such as IL-1 beta, IL-6, and TNF in the
 Covid-19 uninfected Jordanian people with vitamin D deficiency.

 This study aims to assess whether high doses of vitamin D3 may improve immune responses
 against COVID-19 infection in uninfected Jordanian peoples. We hypothesize that Weekly 50,000
 IU vitamin D3 supplements will significantly change immune responses compared with the
 control group.
Inclusion Criteria:

 Age ≥30 years old Male and female Jordanian ASU students and employees who live in Amman.
 Informed written consent from the participant prior to the start of the study. a serum
 25(OH)D concentration less than 30 ng/mL.

 Exclusion Criteria:

 Any eligible subject refuses to apply with informed written consent before the start of the
 study. Men or women previously diagnosed with chronic diseases, including kidney disease or
 GIT problems. Who are receiving vitamin D3 supplements (3 months before the start of the
 study). Pregnant, Breastfeeding females, Females using hormonal contraceptives