Fresh Versus Freeze-only After CAPA IVM on PCOS Patients
Fresh Versus Freeze-only After CAPA IVM on PCOS Patients
IVM (in vitro maturation) has been proved to be a more friendly treatment protocol for PCOS
 (polycystic ovary syndrome) patients compared with conventional controlled ovarian
 stimulation, with less complications (especially ovarian hyperstimulation syndrome), shorter
 treatment duration, lower cost, and acceptable pregnancy outcomes.
IVM (in vitro maturation) has been proved to be a more friendly treatment protocol for PCOS
 (polycystic ovary syndrome) patients compared with conventional controlled ovarian
 stimulation, with less complications (especially ovarian hyperstimulation syndrome), shorter
 treatment duration, lower cost, and acceptable pregnancy outcomes. CAPA (capacitation) IVM
 without hCG (human chorionic gonadotropin) priming, has routinely been used at My Duc
 hospital for nearly 3 years to replace hCG-IVM (with hCG priming) because of absolutely
 synchronized oocyte maturation stage and better embryo results and better pregnancy outcomes.
 However, with CAPA IVM, embryos are freezed-only and will be transferred in the next cycles.
 This process will increase the cost of freezing and thawing embryos, and increase the
 treatment duration, which complicates the IVM procedure and turns IVM into an unfriendly
 protocol to PCOS patients. Therefore, our group conducts this study to find out the
 effectiveness of fresh transfer protocol after CAPA IVM compared with freezing-only CAPA IVM
 protocol. The fresh transfer protocol for CAPA IVM is applied from previous hCG IVM protocol,
 with the use of hCG and exogenous estradiol and progesterone, but at different timings.
Inclusion Criteria:

 -  Women with high AFC (≥24 Antral Follicles in Both Ovaries), including PCOS plus PCO or
 high AFC

 -  Having indications for ART

 -  Having ≤ 2 IVM/IVF attempts

 -  Permanent resident in Vietnam

 -  Agree to have fresh embryos transfer or freeze-only on day 3

 -  Agree to have ≤ 2 embryos transferred

 -  Not participating in another IVF study at the same time

 Exclusion Criteria:

 -  Oocyte donation cycles

 -  Pre-implantation genetic diagnosis (PGD) cycles