Study of Limited Versus Continuous Isoniazid Tuberculosis Preventive Therapy in HIV-infected Persons in Botswana
Study of Limited Versus Continuous Isoniazid Tuberculosis Preventive Therapy in HIV-infected Persons in Botswana
This is a randomized, blinded, two-arm comparative trial of continued versus limited
 isoniazid (INH) tuberculosis (TB) preventive therapy in HIV-infected adults in Gaborone and
 Francistown, Botswana. Subjects will be accrued over two years and followed for a minimum of
 36 months.
Randomized, double blinded, two-arm comparative trial of continuous vs. limited isoniazid
 preventive therapy in HIV-infected adults in Gaborone and Francistown, Botswana. Subjects
 will be accrued over two years and followed for a minimum of 36 months.
Inclusion Criteria:

 1. HIV-infected

 2. Age >=18 years

 3. Tuberculin skin test positive or negative

 4. Laboratory:

 -  Hemoglobin (Hgb) >6.5 gm/dl;

 -  Neutrophil count >1,000 cells/mm3;

 -  Platelets >75,000/mm3;

 -  AST (SGOT) <122 U/L;

 -  Creatinine <1.5 mg/dl;

 -  Beta HCG = negative

 5. Karnofsky performance status >=60

 6. Signed informed consent

 Exclusion Criteria:

 1. History of TB in the last 3 years or current active TB

 2. History of noncompliance to chronic therapies