A Pilot Study to Evaluate the Severity of Motor Dysfunction in Parkinson's Disease Based on AI Video Analysis
A Pilot Study to Evaluate the Severity of Motor Dysfunction in Parkinson's Disease Based on AI Video Analysis
This study is a pilot study, mainly to explore the potential application value of specific
 pattern movement after video-based quantitative methods in the early recognition and
 assessment of Parkinson's disease. According to UPDRS III, a series of motion indicators
 related to the characteristics of the disease were determined and quantitatively analysed.
 Motor function scores were given by the senior physicians and the AI video analysis team
 separately to evaluate the accuracy of the scores of AI video analysis compared with that of
 senior specialists' team of movement disorders.
In this study, participants are asked to perform video-recorded UPDRS-III test, and the
 unmarked motion feature identification and quantitative analysis based on the video were
 conducted.

 The investigators have collected standardized motor function videos of patients with
 Parkinson's disease from outpatient clinics and follow-up since August 2017. Based on the
 UPDRS III motor function test, the investigators screened five pattern actions that are both
 disease-characteristic and easy to visualize, including finger tapping, hand movements,
 pronation-supination movements of hands and gait test. With the assistance of the artificial
 intelligence team, the characteristic value quantification (frequency, distance, angle, etc.)
 of the above pattern actions has been initially implemented. Considering that the
 characteristic values of the pattern action under the identification of video are all
 continuous variables and cannot be directly compared with the discrete UPDRS rating scale,
 the investigators initially explored the construction of deep learning algorithm based on
 UPDRS rating in the previous work to verify the effectiveness of video analysis in motor
 function evaluation.

 In this study, the investigators plan to include patients with Parkinson's disease with
 different disease severity and analyse the consistency between UPDRS scores evaluated by
 specialists of movement disorders and video quantification score. The results of this study
 will hopefully lay a good foundation for launching a large-scale, multi-centre clinical trial
 in the future.
Inclusion Criteria:

 -  The primary criteria for diagnosis are idiopathic Parkinson's disease, defined as
 bradykinesia with resting tremor or muscular rigidity according to MDS-PD diagnosis
 criteria (2015). The examination of major symptoms needs to be performed by the
 methods described in the Unified Parkinson's Disease Rating Scale (UPDRS).

 Exclusion Criteria:

 -  1. Definite cerebellar abnormalities, such as cerebellar gait, limb ataxia, or
 cerebellar eye movement abnormalities (such as sustained staring induced nystagmus,
 giant square wave beats, and distant hypertonia).

 -  2. Downward vertical suprachiasmatic gaze palsy, or selective downward vertical
 scanning is slowing down.

 -  3. Within five years of onset, the disease was diagnosed as a likely frontotemporal
 dementia or primary progressive aphasia (according to revised diagnostic criteria for
 frontotemporal dementia published in 2011).

 -  4. With more than three years after the onset of the disease, Parkinson's disease
 symptoms are still limited to the lower limbs.

 -  5. They have been treated with dopamine receptor blockers or dopamine depletion agents
 and the dosage and duration of administration are consistent with the diagnosis of
 drug-induced Parkinson's disease.

 -  6. Although the condition is at least moderately severe, there is no discernible
 effect on high-dose levodopa therapy.

 -  7. Definite cortical hypoesthesia (such as loss of skin writing and body recognition
 when the primary sensory function pattern is complete), definite motor aphasia of body
 concept, or progressive aphasia.

 -  8. Functional neuroimaging study of the presynaptic dopaminergic system shows normal
 results.

 -  9. There is evidence of Parkinson's disease or other diseases suspected to be related
 to the patient's symptoms, or professional physicians identify they may be other
 syndromes rather than Parkinson's disease based on a complete diagnostic assessment.