Assessment of Burden Disease in Patients With Mast Cell Disorders
Assessment of Burden Disease in Patients With Mast Cell Disorders
The symptoms caused by mast cell disorders can have a significant impact on the state of
 health of individuals, constituting a real burden for them, and consequently altering their
 quality of life. It therefore seems important to clarify the impact on the quality of life,
 on the psycho-affective sphere, on professional life and on the direct and indirect costs
 caused by the disease, as well as on the "patient's remaining burden". It seems possible by a
 longitudinal study (patient follow-up over 1 year).

 Primary objective is Assessment of quality of life in adult patient with mast cell diseases
 at M0.
Mast cell activation symptoms are due to the release of mast cell mediators after
 uncontrolled activation of mast cells. The release by mast cells of mast cell mediators
 (tryptase, histamine, prostaglandins, serotonin) results in mast cell activation symptoms,
 found in mast cell activation syndrome but also in mastocytosis. These symptoms interested
 the skin, gastrointestinal gut, pulmonary, cardiovascular and neuropsychiatric organs, etc.

 In mastocytosis, along with these symptoms of mast cell activation, the infiltration of
 different organs by abnormal mast cells produces many clinical signs related to the excess of
 monoclonal mast cells present in the organs.

 According to our clinical experience, the impact of mast cell disorder on various dimensions
 of life, including economic life, seems important, but it has never accurately evaluated.
Inclusion Criteria:

 -  Adult patient (> 18 years old) with confirmed mast cell disorder according to
 international criteria

 -  Patient affiliated to social security regime

 Exclusion Criteria:

 -  Patient under legal protection (guardianship, curators or court order)

 -  Patient does not speak French