Evaluation the Growth Factors(IGF-1,IGFBP-3and HGH)in Patients With Chronic Liver Disease
Evaluation the Growth Factors(IGF-1,IGFBP-3and HGH)in Patients With Chronic Liver Disease
BACKGROUND The insulin-like growth factor system (IGFs) plays an important role in cell
 growth and differentiation. Nevertheless, the roles played by insulin-like growth factor-1
 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3) and human growth hormone
 (HGH) in the progression of chronic liver disease remain to be elucidated and investigated.

 METHODS The subjects in the present study included 60 healthy controls, 30 hepatitis
 patients, 60 liver cirrhosis patients and 60 untreated hepatocellular carcinoma patients.
 Blood was drawn by venipuncture into Venoject tubes. To find the possible correlations
 between liver damage and IGFs, serum IGF-1, GH, IGFBP-3 concentration and related biochemical
 parameters were measured. We used immunoradiometric assay to determine the levels of IGF-1,
 HGH and IGFBP-3 in serum.
healthy controls:one blood sample (7.5 cc) hepatitis: three blood samples, at admission, at
 3rd and 7-10th day of admission liver cirrhosis: two blood samples, at 1-2 years interval
 (7.5 cc/each session) hepatocellular carcinoma: three blood samples, before, 1 day after and
 at the 7th day of transcatheter arterial chembolizatiom
Inclusion Criteria:

 -  Clinical diagnosis of Hepatocellular carcinoma

 -  Must be primary Hepatocellular carcinoma and untreament

 Exclusion Criteria:

 -  treatment Hepatocellular carcinoma