Evaluation of Using Vibrotactile Coordinated Reset for Management of Parkinson's Disease
Evaluation of Using Vibrotactile Coordinated Reset for Management of Parkinson's Disease
This is a study to evaluate peripheral vibrotactile coordinated reset stimulation for
 Parkinson's disease seeks to explore the safety and efficacy of an experimental non-invasive
 method to aid in the symptoms of Parkinson's disease. The purpose of the study is to verify
 the safety and tolerability of non-painful sensory (tactile) vibratory stimulation delivered
 to the fingertips of patients with Parkinson's disease.
This study aims to evaluate the safety and efficacy of a non-invasive, experimental method to
 aid in the symptoms of Parkinson's disease. A glove device produces non-painful sensory
 (tactile) vibratory stimulation to the fingertips of Parkinson's patients. Participants will
 either be randomized to receive the real stimulation, or fake ("sham") stimulation. This will
 help investigators compare durability and efficacy of the tactile stimulation to current
 medical therapy. Participants randomized to the "sham" arm will be allowed to receive the
 real stimulation after 3 months of follow-up. All patients will be followed for total of 6
 months (both real and sham stimulation groups). If the results of this study suggest that
 vibrotactile CR stimulation is safe and effective for the treatment of Parkinson's disease,
 this non-invasive treatment approach would have a substantial impact on Parkinson's disease.
Inclusion Criteria:

 1. Age 18 and older

 2. Diagnosis of idiopathic Parkinson's disease.

 3. Levodopa responsiveness as defined by at least a 30% reduction in MDS-UPDRS motor
 subscale (excluding tremor scores) in the ON vs OFF medication state.

 4. Willing to participate in the vibrotactile stimulation sessions for 2 consecutive days
 initially and willing to return for follow-up visits

 5. Able to provide informed consent.

 6. Appropriate social support

 Exclusion Criteria:

 1. Hoehn and Yahr stage greater than 3 in the on medication state

 2. Presence of other forms of non-idiopathic parkinsonism, including but not limited to
 atypical parkinsonism, medication induced parkinsonism, vascular Parkinsonism

 3. Any illness that in the investigator's opinion precludes participation in the study

 4. Subjects unable to communicate with the investigator and staff