Multiple-dose,Double-blind,Placebo-controlled Study of Sodium Oxybate in Patients With Essential Tremor
Multiple-dose,Double-blind,Placebo-controlled Study of Sodium Oxybate in Patients With Essential Tremor
To determine the relationship between drug plasma levels and safety, tolerability and
 efficacy in patients with essential tremors after dosing with Sodium oxybate
Inclusion Criteria:

 -  Diagnosis of moderate or severe classic essential tremor (bilateral, largely symmetric
 postural or kinetic tremor involving hands and forearms.

 -  Willingness to abstain from ethanol and caffeine intake for at least 48 hours prior to
 Days 1 and 4 and on inpatient days

 Exclusion Criteria:

 -  Subjects with a clinically significant unstable medical abnormality, chronic disease
 or history or presence of significant hepatic, renal, endocrine, cardiovascular,
 gastrointestinal, pulmonary, psychiatric, or metabolic disease or any other
 abnormality

 -  Subjects who are on sodium-restricted diets

 -  Subjects with a known history of sleep apnea