Mass Balance Recovery, Metabolite Profile and Metabolite Identification of [14C]NXL104
Mass Balance Recovery, Metabolite Profile and Metabolite Identification of [14C]NXL104
A study to look at how radiolabelled NXL104 is taken up, broken down and removed by the body
 when given as an injection into the blood stream.
An Open Label Single-Dose Study in Healthy Male Subjects Designed to Assess the Mass Balance
 Recovery, Metabolite profile and Metabolite Identification of [14C]NXL104.
Inclusion Criteria:

 -  Provision of informed consent prior to any study specific procedures.

 -  Healthy male subjects aged 30-65 years inclusive.

 -  Male subjects should be willing to use an adequate method of contraception (as defined
 in Section 5.1) from the day of dosing until 3 months after dosing with the
 investigational product.

 -  Have a body mass index (BMI) between 18 and 32 kg/m2 inclusive and weigh at least 50
 kg and no more than 100 kg.

 -  Clinically normal physical examination and laboratory findings as judged by the
 investigator, including negative test results for drug abuse, alcohol, CO breath test
 and negative test results for Hepatitis B surface antigen, antibodies to Hepatitis C.

 Exclusion Criteria:

 -  Any clinically significant disease or disorder (e.g. cardiovascular, pulmonary,
 gastrointestinal, liver, renal, neurological, musculoskeletal, endocrine, metabolic,
 malignant, psychiatric, major physical impairment).

 -  Any clinically relevant abnormal findings in physical examination, vital signs,
 clinical chemistry, haematology, urinalysis, which, in the opinion of the
 investigator, may put the subject at risk because of his participation in the study.

 -  QTc > 450 ms or QT > 500 ms or other ECG abnormality making interpretation more
 difficult, as judged by the investigator, or a history of additional risk factors for
 Torsades de Points (eg heart failure, hypokalemia, family history of long QT
 syndrome).

 -  Radiation exposure from clinical studies, including that from the present study,
 excluding background radiation but including diagnostic X-rays and other medical
 exposures, exceeding 5 mSv in the last twelve months or 10 mSv in the last five years.

 -  Participation in another clinical study with an investigational product during the
 last 3 months.