Algorithm Guided Treatment Strategies for Major Depressive Disorder
Algorithm Guided Treatment Strategies for Major Depressive Disorder
The purpose of this study is to compare treatment outcomes between measurement based
 Algorithm Guided Treatment and Treatment As Usual strategies in a Chinese population with
 major depressive disorder.
The AGT arm includes a 2-step medication monotherapy and a combination treatment algorithm.
 The first step (level 1) includes two medication monotherapy options: escitalopram and
 mirtazapine. For those participants who don't remit with the initial intervention after up to
 6 to 12-week treatment, the second step (level 2) with a variety of treatment options will be
 provided. In level 2 intervention, a switch strategy for those who don't remit with
 escitalopram will be switched to mirtazapine, or for those who don't remit with mirtazapine
 will be switched to escitalopram, combination strategy (i.e. escitalopram plus mirtazapine)
 and augmentation strategy (i.e. escitalopram or mirtazapine plus either rTMS or mECT).
 Participants who don't get remission in level 1 intervention will be encouraged to enter
 level 2 interventions based on intend-to-treatment principle. The TAU arm as control
 intervention is performed using the psychiatrist's individual discretion based on his/her
 expertise and knowledge.

 Participants will be recruited consecutively in 8 psychiatric settings across China and
 randomized into any of the two initial interventions of AGT or TAU arm. Follow-up interviews
 will be performed monthly for all participants who finish any acute treatment of AGT or TAU.
 The follow-up period will last up to 6 months.
Inclusion Criteria:

 -  Meets Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV)
 criteria for single or recurrent nonpsychotic major depressive disorder

 -  Age 18-75

 -  Written informed consent completed

 -  Scores 14 or higher on the 17-item Hamilton Depression Rating Scale

 -  Initial treatment with escitalopram or mirtazapine or other antidepressants is
 clinically appropriate

 Exclusion Criteria:

 -  History of bipolar disorder

 -  Concurring psychotic disorders

 -  Scores 3 or higher on item 3 (suicidal) of HRSD-17

 -  History of nonresponse to an adequate trial of escitalopram and/or mirtazapine

 -  Has general medical condition, which contraindicates any leve 1 or 2 treatment option

 -  Is on concomitant medication, which contraindicates any leve 1 or 2 treatment option

 -  Any contraindication for mECT or rTMS

 -  Is pregnant or breast feeding or is planning to get pregnant