In Vitro Maturation (IVM) for Polycystic Ovary Syndrome (PCOS)
In Vitro Maturation (IVM) for Polycystic Ovary Syndrome (PCOS)
This pilot study will be a prospective investigation to study the efficacy and safety of
 In-Vitro Maturation (IVM) for women with Polycystic Ovarian Syndrome (PCOS). There will be 10
 subjects total in this Study. There will be no blinding to treatment.

 In-Vitro Maturation will provide a viable, safe option for women with PCOS attempting
 pregnancy through the use of Assisted Reproductive Technology (ART).
Inclusion Criteria

 1. 10 women between the ages of 18-34 inclusive at time of signing Informed Consent Form.

 2. A diagnosis of PCOS by their primary MD

 3. An Antral Follicular Count (AFC) of > 12 on one ovary on at least one occasion

 4. A day 3 FSH level of <8 IU/mL

 5. In good general health off of current medications which may confound response to study
 medications.

 6. Desire to seek pregnancy actively during the study period by IVF-ICSI.

 7. A normal uterine cavity must have been confirmed by either hydrosonogram or
 hysteroscopy within two years of entering the study.

 8. Male partner able to provide adequate semen sample by ejaculation (no TESE)

 Exclusion Criteria

 1. Current pregnancy

 2. Patients with uncorrected thyroid disease (defined as TSH < 0.2 mIU/ML or >5.5
 mIU/mL). A normal level within the last year is adequate for entry.

 3. Patients with poorly controlled diabetes (HgB A1C over 8.0 ng/dL).

 4. Patients enrolled simultaneously into other investigative studies that require
 medications, proscribe the study medications, limit intercourse, or otherwise prevent
 compliance with the protocol.

 5. Patients with significant anemia (Hemoglobin < 10 mg/dL).

 6. Patients enrolled simultaneously into other investigative studies that would interfere
 with this research study.

 7. have any contraindications to using birth control pills (oral contraceptives) as
 determined by the attending physician (e.g. history of thromboembolism or
 estrogen-dependent malignancy, such as breast cancer, etc.) -