Environmental Control as Add-on Therapy in Childhood Asthma
Environmental Control as Add-on Therapy in Childhood Asthma
This study evaluates the effects of adding on an environmental home intervention to standard
 asthma medication management on controller medication requirements among children and
 adolescents with asthma. The investigators hypothesize that the addition of an
 individually-tailored, multi-faceted Environmental Control Strategy (ECS) to guidelines-based
 controller medication will result in less controller medication requirement and allergic
 inflammation than controller medication alone among urban asthmatic children.
The study is a parallel arm study of an individually tailored, multi-faceted ECS plus
 controller medication titration versus controller medication titration alone. After a 4-week
 run-in period to stabilize the asthma, the investigators will randomize 200 Baltimore
 children with persistent asthma and a recent exacerbation in a 1:1 ratio to the two arms and
 follow the children for six months. There will be five clinic visits and three home visits
 over this time period for clinical and home assessments, respectively. There will be up to
 four environmental intervention visits for participants randomized to the environmental
 control plus controller medication group. The environmental modules include mouse, cockroach,
 furry pets, dust mites, and smoking. Air purifiers and laundered bedding are also included in
 this arm. Participants randomized to the controller medication group have the option of
 having one home visit after completing the study at which the participants will receive home
 intervention services that the environmental control plus controller medication group
 received. Participants will have repeated assessment of: controller medication requirements;
 secondary clinical, physiologic, and inflammatory outcomes; and particulate matter (PM), air
 nicotine, and allergen levels.
Inclusion Criteria:

 -  Have physician-diagnosed asthma at least 1 year prior to the baseline visit, or asthma
 symptoms for at least 1 year

 -  Meet criteria for current persistent asthma defined as either:

 1. On a long-term controller medication for asthma, or

 2. Meet National Asthma Education and Prevention Program (NAEPP) guideline
 requirements for persistent disease:(46)

 -  Asthma symptoms 3 or more days per week over the past 2 weeks or

 -  Nocturnal asthma symptoms at least 3 times in the past month

 -  Have evidence of uncontrolled disease as defined by at least one of the following:

 1. One asthma-related unscheduled visit to an emergency department (ED), clinic or
 urgent care facility in the previous 12 mo

 2. One asthma-related overnight hospitalization in the previous 12 mo

 3. One or more bursts of oral corticosteroids in the previous 12 mo

 -  Reside within a geographic area of the study site so that home visits are feasible.

 -  Have no plans to move within the upcoming 6 months

 -  Have insurance to cover prescription medications.

 -  Have a positive skin test (net wheal ≥2mm) to cat, dog, mouse, cockroach, or dust
 mites or have a positive cat, dog, mouse, German cockroach, or D. farinae-specific
 immunoglobulin E (IgE) test, as quantified using the ImmunoCAP system (≥0.35 kU/L)

 Exclusion Criteria:

 -  Lung disease, other than asthma, that requires daily medication

 -  Cardiovascular disease that requires daily medication, excluding hypertension

 -  Taking a beta-blocker

 -  Allergy to dairy

 -  On Xolair < 5 months

 -  On immunotherapy and has not reached maintenance dose

 -  Sleeping in another home 4 or more nights/week

 -  Active smoker defined as a positive urine screen for high levels of urine cotinine

 -  Unable to access areas of home necessary to conduct extermination