Can Interval Walking Influence on Fatigue in the Danish Cohort of Myasthenia Gravis Patients
Can Interval Walking Influence on Fatigue in the Danish Cohort of Myasthenia Gravis Patients
The study is a controlled, randomized intervention trial. Patients are randomized into either
 an intervention group or a control group. The duration of the study is 10 weeks. Patients in
 the intervention group participate in a 10 weeks exercise program consisting of 150 minutes
 interval walking per week administered by an app on the patient's telephone. Patients in the
 control group live as usually, with a maximum of 30 minutes aerobic exercise per week.

 Before and after the 10 weeks study period, patients (from both the intervention and the
 control group) participate in a 2 hours session of functional testing (e.g. walk tests, test
 of muscle strength ect.) at Rigshospitalet.
Inclusion Criteria:

 -  Able to provide signed informed consent.

 -  Able to read and understand Danish or English.

 -  Diagnosed with mild to moderate myasthenia gravis (I-IV on the Myasthenia Gravis
 Foundation of American Clinical Classification, MGFA).

 -  Documented history of acetylcholine receptor (AChR) or Muscle Specific Kinase (MuSK)
 antibody positive, or abnormal repetitive nerve stimulation testing (decrement > 10%)
 on EMG or abnormal single fiber EMG (conduction block or jitter) or based on their
 clinical history and symptom improvement with acethylcholinesterase inhibitors.

 -  If the patient is on oral corticosteroids, the dose must be stable for at least 1
 month prior to inclusion.

 -  If the patient is on cholinesterase inhibitors the dose must be stable 2 weeks prior
 to inclusion.

 Exclusion Criteria:

 -  MGFA grade V disease

 -  Other disorders that are not related to MG, or drugs, that interfere with muscle
 strength, balance and fatigue.

 -  Serious medical illness (e.g. uncontrolled insulin dependent diabetes mellitus,
 symptomatic coronary artery disease, and cancer).

 -  Dementia or pregnancy.

 -  Unspecified reasons judged by the investigator.