Nasal High Frequency Oscillation for Respiratory Distress Syndrome in Twins Infants
Nasal High Frequency Oscillation for Respiratory Distress Syndrome in Twins Infants
The investigators compared advantages and disadvantages of two forms of noninvasive
 respiratory support -noninvasive high-frequency oscillatory ventilation (nHFOV) or nasal
 continuous positive airway pressure (nCPAP) -as a primary mode of ventilation in preterm
 twins infants with respiratory distress syndrome
Invasive ventilation is related to development of adverse pulmonary and nonpulmonary outcomes
 in ventilated infants. Various modes of noninvasive respiratory support are being
 increasingly used to minimize the incidence of bronchopulmonary dysplasia (BPD). The aim of
 this trial to compare the effects of noninvasive high frequency oscillatory ventilation
 (NHFOV) and nasal continuous positive airway pressure (NCPAP) in preterm twins infants as the
 primary mode.
Inclusion Criteria:

 1. Gestational age (GA) is from 26 to 37 weeks;

 2. Diagnosis of respiratory distress syndrome. The diagnosis of respiratory distress
 syndrome will be based on clinical manifestations (tachypnea, nasal flaring and or
 grunting) and chest X-ray findings;

 3. Respiratory distress syndrome Silverman score >5;

 4. Informed parental consent has been obtained.

 Exclusion Criteria:

 1. Severe respiratory distress syndrome requiring early intubation according to the
 American Academy of Pediatrics guidelines for neonatal resuscitation7;

 2. Major congenital malformations or complex congenital heart disease;

 3. Group B hemolytic streptococcus pneumonia, septicemia, pneumothorax, pulmonary
 hemorrhage;

 4. Cardiopulmonary arrest needing prolonged resuscitation;

 5. transferred out of the neonatal intensive care unit without treatment.