Polycystic Ovary Syndrome (PCOS): Effect Of Letrozole and Berberine
Polycystic Ovary Syndrome (PCOS): Effect Of Letrozole and Berberine
Polycystic ovary syndrome (PCOS) is a heterogeneous disorder affecting almost4%-7% of the
 female population of reproductive age. Its heterogeneity is characterized by a wide spectrum
 of features, including ovulatory dysfunction and infertility, hyperandrogenism,
 hyperinsulinemia, insulin resistance (IR), and progression to type 2 diabetes.Since the Ming
 Dynasty in China,PCOS has been defined as "phlegm and wetness"infertility in traditional
 Chinese medicine ,namely "metabolic infertility".Chinese herbs have been used to treat PCOS
 for thousands of years with good effects.Berberine has also been used for diabetic patients
 in traditional Chinese medicine for hundreds of years. Recent studies have reported its
 effects on hyperglycemia and dyslipidemia.The purpose of this study is to determine whether
 Letrozole combined with berberine are effective in the treatment of infertile PCOS patients.
Inclusion Criteria:

 -  Chinese women

 -  Age between 20 and 40 years.

 -  Confirmed diagnosis of PCOS according to the Rotterdam 2003 criteria (2 out of 3):

 1. Oligo- or anovulation

 2. Clinical and/or biochemical signs of hyperandrogenism

 3. Polycystic ovaries and exclusion of other etiologies (congenital adrenal
 hyperplasia, androgen-secreting tumors, Cushing's syndrome)

 -  At least one patent tube and normal uterine cavity shown by hysterosalpingogram,
 HyCoSi or diagnostic laparoscopy within three years.

 -  Sperm concentration 20×106/mL and progressive motility (grades a and b) ≥50%.

 Exclusion Criteria:

 -  Use of hormonal drugs or other medications including Chinese herbal prescriptions in
 the past 3 months.

 -  Patients with known sever organ dysfunction or mental illness.

 -  Pregnancy, post-abortion or postpartum within the past 6 weeks.

 -  Breastfeeding within the last 6 months.

 -  Not willing to give written consent to the study.