Detailed Clinical, Biochemical and Genetic Characterization in Gonadotropin-releasing Hormone (GnRH) Deficiency Disorders
Detailed Clinical, Biochemical and Genetic Characterization in Gonadotropin-releasing Hormone (GnRH) Deficiency Disorders
In this study, we will measure levels of reproductive hormones and metabolic markers in
 subjects with isolated GnRH deficiency disorders and compare them to healthy control
 populations. Our goals are (1) to chart the range of hormonal and metabolic biomarkers in
 healthy subjects and those with reproductive disorders and (2) to correlate reproductive and
 metabolic phenotypes with genetic changes within patients with reproductive disorders and
 healthy controls.
Inclusion Criteria:

 -  Over the age of 18 for men

 -  Between the ages of 18 and 40 for women

 -  For reproductive disorder population: Current or previous diagnosis of Idiopathic
 Hypogonadotropic Hypogonadism or Hypothalamic Amenorrhea

 Exclusion Criteria:

 -  chronic disease (hypertension, high cholesterol, diabetes, asthma, etc)

 -  polycystic ovarian syndrome for women

 -  prescription medication use (other than allergy meds) for control populations

 -  irregular menstrual cycles for healthy female control population (cycle length longer
 than 35 days or shorter than 25 days. cycle length varies by more than 5 days. less
 than 9 periods per year)