Antioxidant Supplement Associated With Oral Probiotics in Patients With PCOS in IVF
Antioxidant Supplement Associated With Oral Probiotics in Patients With PCOS in IVF
The aim of the study is to study the effect of an antioxidant food supplement associated with
 probiotics on the oocyte quality response, oxidative stress and microbiota function in an in
 vitro fertilization cycle in patients with polycystic ovarian syndrome
After being informed about the study, all patients meeting the inclusion/exclusion criteria
 and giving written informed consent will be randomized in a double-blind manner in a ratio
 1:1 to receive the antioxidant supplementation associated with probiotics (Myo-Inositol,
 D-Chiro-Inositol, folic acid, selenium, vitamin D, Melatonin, Lactobacillus rhamnosus,
 Lactobacillus cripatus and Lactobacillus plantarum) or placebo (folic acid) once daily.
Inclusion Criteria:

 -  Age:18-38 years old

 -  Diagnosis of PCOS according to compliance with the Rotterdam criteria

 -  BMI >= 25

 Exclusion Criteria:

 -  Hormonal contraceptive, insulin sensitizers such as metformin, inositols,
 antioxidants, vitamin supplements except folic acid, GnRH analogs, steroidal drugs or
 others with anti-inflammatory properties, antibiotics, probiotics, laxatives use in
 the 3 months prior to recruitment

 -  Tobacco consumption in last 12 months

 -  Endometriosis, hydrosalpinx not surgically treated, acute or chronic inflammatory
 diseases, systemic immune diseases, other endocrine diseases or dysfunctions except
 for PCOS and subclinical hypothyroidism treated with low doses of levothyroxine (eg
 congenital adrenal hyperplasia, Cushing's syndrome, androgen-secreting tumors,
 Diabetes Millitus, hyperprolactinemia, hyperglycemia), active neoplastic disease or
 without evidence of complete remission for at least 5 years,

 -  Active participation in an active weight reduction program or hypocaloric diet during
 the study period. No change in habits will be taught during the study period

 -  Hypersensitivity to any of the components in the Fertybiotic Mujer Plus® formulation