Cohort Study to Evaluate Ovarian Function
Cohort Study to Evaluate Ovarian Function
The study will collect the clinical and biological data of the patients, the investigators
 could further analyse and identify the risk factors and optimize clinical treatment method.
 Besides, population-based healthy people with informed consent are also collected.
Menopause is the last step in the process of ovarian ageing. Decrease in follicle numbers
 dictates the onset of cycle irregularity and the cessation of menses. At the same time,
 decaying in oocyte quality contributes to the gradual decline in fertility. Endocrine changes
 mainly depend on the decline in the negative feedback by ovarian factors at the
 hypothalamo-pituitary unit. The declining antral follicle cohort(AFC) with age first results
 in gradually elevated FSH levels. The gradual decline in the size of AFC is best represented
 by decreasing levels of anti-Mullerian hormone. The identification of women who have severely
 decreased ovarian reserve is clinically relevant. Ovarian reserve tests have appeared to be
 fairly accurate in predicting response to ovarian stimulation in the assisted reproductive
 technology (ART) setting. The capacity to predict the chances for spontaneous pregnancy or
 pregnancy after ART appears very limited. As menopause and the preceding decline in oocyte
 quality seem to have a fixed time interval, tests that predict the age at menopause may be
 useful to assess individual reproductive lifespan like genetic studies, ovarian ageing
 mechanism studies and epigenetic studies.

 Heart disease remains a major cause of death among women in China. We focuses on physiologic
 endogenous sex steroid levels and heart disease especially for CAD among postmenopausal women
 with natural or surgical menopause. Now there are more and more reasons to seek evidence for
 associations of circulating estrogen or other endogenous sex steroid levels and CAD. In the
 future, we design a cohort study to confirm whether ovarian sex steroid hormonal changes is
 associated with CAD postmenopausal women, or there may be other components explaining the
 gender differences in CAD patterns.

 Premature ovarian failure(POF), is a disorder of infertility characterized by amenorrhoea,
 low estrogen levels and increased gonadotropin levels in women aged <40 years. POF is the
 result of premature exhaustion of the follicle pool or can be attributed to follicular
 dysfunction, for example, owing to mutations in the FSH receptor or steroidogenic cell
 autoimmunity. Moreover, advances in cancer therapeutics over the past decades have led to
 increasing survival rates for both paediatric and adult malignancies. Given the gonadotoxic
 effect of many cancer treatments, more women develop POF. Markers that predict whether women
 are at risk of POF would, therefore, aid in early diagnosis and fertility counselling.

 The history of past and present status has been taken in our research. Women on the process
 of natural aging and disease-induced ovarian aging are all included. The key factors that
 influence ovary aging may be identified by epidemiological and molecular biological research.
Inclusion Criteria:

 -  Karnofsky Performance Statue ≥ 70,

 -  WBC > 3,000/mm³,

 -  Hb > 9.0g/dl,

 -  Platelet > 100,000 /mm³,

 -  SGOT/SGPT < 60 IU/L,

 -  T-Bil < 1.5 mg/dL,

 -  Cr < 1.2 mg/dL,

 -  PaO2 > 80 torr,

 -  normal ECG,

 -  Written informed consent.

 Exclusion Criteria:

 -  Patients without information,

 -  clinical risk factors,

 -  Patients who have active infection.