Molecular and Immunohistochemical Profiling of Tumors in Patients With Parathyroid Tumors
Molecular and Immunohistochemical Profiling of Tumors in Patients With Parathyroid Tumors
This trial studies molecular and immunohistochemical profiling of tumors in patients with
 parathyroid tumors. Studying molecular and immunohistochemical profiling of tumors may help
 doctors avoid inconsistencies in diagnosis, unnecessary or incomplete surgery, surgical
 morbidity, psychological stress, and inadequate follow up.
PRIMARY OBJECTIVES:

 I. To determine the differences in clinical behavior and immunohistochemical (IHC) biomarkers
 between parathyroid carcinoma (PC), atypical neoplasm (AN) and parathyroid adenoma (PA).

 II. To determine which potential genes can be used in patients with parathyroid tumors for
 diagnostic purposes.

 OUTLINE:

 Previously collected tumor tissue and blood samples are analyzed via immunohistochemical
 profiling for identifying potential genes showing molecular aberrations as other types of
 cancer.
Inclusion Criteria:

 -  The patient cohort for this study consists of all patients within the prospectively
 maintained parathyroid database within the Department of Surgical Oncology at the
 University of Texas MD Anderson Cancer Center (MDACC) or from collaborating sites,
 with tissue or blood available from 1968-2015, previously consented for the use of the
 tissue for research purposes (via Protocols LAB 08-0034, PA11-0695 and LAB03-0320 or
 the appropriate external mechanism for collaborating sites).

 -  All patients with a known diagnoses of primary hyperparathyroidism (PHPT)
 operated/treated in the Department of Surgical Oncology of MDACC or at a collaborating
 site. Patients that have provided consent for the use of the tissue or blood for
 research purposes will then be considered for our study (via Protocol LAB03-0320 and
 LAB 08-0034 or the appropriate external mechanism for collaborating sites).

 -  All consented patients with known diagnoses of PHPT with a histopathological diagnosis
 of: parathyroid carcinoma, atypical parathyroid neoplasm or parathyroid adenoma. There
 will be no restrictions on age, gender, or ethnicity.

 -  Selected patients obtained through outside collaboration who meet the selection
 criteria for tissue availability and diagnostic suitability for inclusion in the
 study.

 Exclusion Criteria:

 -  Patients without tissue available for analysis.