Targeting of UnControlled Hypertension in Emergency Department
Targeting of UnControlled Hypertension in Emergency Department
The proposed project underscores the following: 1) The prevalence of uncontrolled/undiagnosed
 hypertension (HTN) in underrepresented groups presenting to the ED is alarmingly high, and 2)
 ED engagement and early risk assessment/stratification is a cost-effective, feasible
 innovation to help close health disparity gaps in HTN. This proposal involves a two-arm
 randomized controlled trial of up to 770 patients from the Emergency Department at University
 of Illinois Hospital with elevated blood pressure (BP). The primary objective is to determine
 the effectiveness of an emergency department-initiated Educational and Empowerment (E2)
 intervention with a Post Acute Care Hypertension Consultation (PACHT-c) intervention (arm 2)
 on the primary outcome of mean systolic blood pressure (SBP) differences between the two
 trial arms at 6-months post intervention. Secondary objectives include evaluating the
 effectiveness of this ED education and empowerment intervention on mean SBP and diastolic
 blood pressure (DBP) differences at 3-months, and mean DBP differences at 6-months.
 Additionally improvement in cardiovascular risk score (as measured by the Atherosclerotic
 Cardiovascular Disease (ASCVD) Risk Score), medication adherence (as measured by the Modified
 Morisky Scale), primary care engagement (measured by compliance with outpatient follow-up
 appointments), and HTN knowledge improvement (as measured by a validated HTN knowledge
 survey).
The study is a single-site randomized controlled trial (RCT) focused on a high-risk ED
 population with evidence of moderately elevated BP (≥140/90 mmHg) at discharge. ED patients
 will be recruited and randomized into two arms: 1) usual care (preprinted discharge
 instructions and 48-72 hour referral to a federally qualified health center (FQHC) or
 assigned provider as appropriate); 2) ED-initiated E2 intervention program followed by 48-72
 hour referral to a FQHC (or assigned health center). Based on the ED population demographics
 (70% ethnic minorities), the majority of participants will be underrepresented minorities
 (NHB and Hispanic) and low-income individuals. The investigators propose the following
 specific aims and hypotheses:

 Aim 1: Evaluate the effectiveness of an ED-based E2 + PACHT-c intervention (arm 2) on the
 primary outcome of mean SBP difference at 6-months post-intervention compared to usual care
 (arm 1).

 H1: The mean SBP difference (from baseline) will be significantly greater in the E2+ PACHT-c
 group (arm 2) compared to the usual care group (arm 1) at 6- months post-randomization, i.e.,
 SBP change in arm 2 > arm 1 at 6-months post-randomization.

 Aim 2: Evaluate the effectiveness of an ED-based E2 intervention with PACHT-c on the
 secondary outcome of mean SBP and DBP differences at 3-months, and mean DBP differences at 6
 months post-intervention compared to usual care.

 H2: The mean SBP and DBP differences from baseline to 3- months post-intervention and mean
 DBP at 6-months post intervention will be significantly greater in the ED-based E2
 intervention compared to the usual care group, i.e., SBP and DBP change in arm 2 > arm 1 at 3
 -months post-intervention and DBP change in arm 2 > arm 1 at 6 -months post-intervention.

 Aim 3: Examine if the E2 intervention reduces racial disparities. Specifically, if the
 intervention is as effective in racial minorities as non-minorities. This will be an
 exploratory analysis and will primarily focus on changes in cardiovascular risk
 score/profile. Also included will be an assessment of intervention mediators: primary care
 engagement, medication adherence, and HTN knowledge in these same patients at 3 and 6-months
 post randomization-intervention.
Inclusion Criteria:

 -  BP>=140/90 and <=180/110 mm Hg at time of discharge from ED

 -  Verbal fluency in English or Spanish

 -  Age 18-75 years

 Exclusion Criteria:

 -  Unable to verbalize comprehension of study, impaired decision-making or documented
 dementia

 -  Plans to move from Chicago area within the next year

 -  Pregnant or trying to get pregnant