Direct Measurement of Proinsulin Clearance in Humans
Direct Measurement of Proinsulin Clearance in Humans
Researchers are trying to determine how quickly proinsulin is cleared from the circulation.
proinsulin clearance is necessary to determine the rate of secretion into the circulation
Inclusion Criteria:

 -  Weight-stable, non-diabetic subjects from Biobank participants at Mayo Clinic,
 Rochester

 Exclusion Criteria:

 -  Age < 25 or > 65 years (to avoid studying subjects who could have latent type 1
 diabetes, or the effects of age extremes in subjects with normal or impaired fasting
 glucose).

 -  HbA1c ≥ 6.5%

 -  Use of glucose-lowering agents.

 -  For female subjects: positive pregnancy test at the time of enrollment or study

 -  History of prior upper abdominal surgery such as adjustable gastric banding,
 pyloroplasty and vagotomy.

 -  Active systemic illness or malignancy.

 -  Symptomatic macrovascular or microvascular disease.

 -  Hormone replacement therapy >0.625 mg premarin daily