Genomic Analysis of Patients With Chronic Lymphocytic Leukemia
Genomic Analysis of Patients With Chronic Lymphocytic Leukemia
This study aims to characterize clonal evolution in chronic lymphocytic leukemia (CLL) using
 different approaches and to identify a possible association with disease progression, i.e.
 therapy initiation.

 1. Samples This monocentric study is carried out using representative bioarchived leukemic
 samples with a diagnosis of CLL, either at diagnosis or at evolution. These bioarchived
 samples were collected locally at our center during years of diagnostic activity, and
 were accurately pathologically, cytogenetically and molecularly characterized.

 2. Clinical data The clinical data were retrospectively collected through collaboration
 with the referring physicians.

 3. Methods Samples will be investigated by means of (1) conventional cytogenetics, (2)
 fluorescence in situ hybridization (FISH) and (3) SNP-arrays. After analysis of the
 array data sets, significant results will be validated and in addition, results will be
 correlated with clinical data.
Inclusion Criteria:

 -  diagnosis of CLL,

 -  at least two available stored samples

 Exclusion Criteria:

 -  at least one inclusion criterium not fulfilled