A Comparison of the Effects of Desflurane and TIVA on Antioxidant System in Morbidly Obese Patients
A Comparison of the Effects of Desflurane and TIVA on Antioxidant System in Morbidly Obese Patients
With the development of technology, the safety of anesthesia devices and the progression of
 monitoring techniques affect the anesthetic management. There are some disadvantages such as
 high cost of inhalation anesthetics and long postoperative recovery time. The effects of
 total intravenous anesthesia (TIVA), which has been used for many years and whose positive
 aspects are well known, on antioxidant system in high risk patients such as morbid obese
 should be investigated. The aim of this study was to compare the effects of desflurane
 anesthesia and total intravenous anesthesia (TIVA) on the antioxidant system in morbidly
 obese patients undergoing bariatric surgery.
Obesity is a chronic disease that negatively affects the quality and duration of life. It is
 one of the most important health problem in the world and very common in Turkey. Morbid
 obesity operations have started to be performed frequently in our country with the effective
 results obtained with the continuation of weight loss after being widely applied in Europe
 and the United States. In our country, with the increase of obesity, laparoscopic bariatric
 is preferred especially with low complication rates.

 Inhalation anesthesia is still a major source of chemical hazard in the hospital environment
 due to the widespread use in operating rooms. Factors affecting the presence of anesthetic
 gases in the environment; device leakage, ventilation, fresh gas flow and operation of the
 air wasting system. Long-term exposure to anesthetic gases is known to adversely affect the
 health of the workers in the operating room.

 It has been shown that many anesthetic agents produce free radicals and alter serum
 antioxidant levels in patients. Antioxidant enzymes clean free radicals. Free radicals
 induced by various diseases can trigger oxidative stress and result in increased oxidative
 products. It was reported that particularly desflurane induced oxidative stress and increased
 oxidative products. At the same time, it was reported that desflurane triggered local and
 systemic oxidative stress in the experimental studies, but propofol had antioxidant
 properties.

 With the development of technology, the safety of anesthesia devices and the progression of
 monitoring techniques affect the anesthetic management. There are some disadvantages such as
 high cost of inhalation anesthetics and long postoperative recovery time. The effects of
 total intravenous anesthesia (TIVA), which has been used for many years and whose positive
 aspects are well known, on antioxidant system in high risk patients such as morbid obese
 should be investigated. The aim of this study was to compare the effects of desflurane
 anesthesia and total intravenous anesthesia (TIVA) on the antioxidant system in morbidly
 obese patients undergoing bariatric surgery.
Inclusion Criteria:

 -  American Society of Anesthesiology score I-III,

 -  18-65 years,

 -  BMI> 40

 Exclusion Criteria:

 -  American Society of Anesthesiology IV,

 -  Under 18 years,

 -  Over 65 years,

 -  Obstetric patients,

 -  Uncontrolled diabetes mellitus, cardiovascular and pulmonary disease,

 -  Cerebrovascular disease,

 -  Patients who refused informed consent forms