Intensity-Modulated Radiation Therapy in Treating Younger Patients With Lung Metastases
Intensity-Modulated Radiation Therapy in Treating Younger Patients With Lung Metastases
This pilot clinical trial studies intensity-modulated radiation therapy (IMRT) in treating
 younger patients with lung metastases. Specialized radiation therapy that delivers a high
 dose of radiation directly to the tumor may kill more tumor cells and cause less damage to
 normal tissue.
OBJECTIVES:

 I. To demonstrate the feasibility of delivering cardiac-sparing IMRT in a multi-institutional
 setting with central quality control for children and young adults with metastatic tumors in
 the lungs.

 II. To prospectively determine the dosimetric advantages of whole lung IMRT treatment over
 standard whole lung irradiation by comparing treatment plans and different organ dose-volume
 histograms such as lungs, heart, thyroid gland, liver etc. in all patients enrolled in this
 study.

 III. To determine the short-term efficacy (lung-metastases free survival) and acute tolerance
 of whole lung IMRT at a minimum period of six months after IMRT.

 OUTLINE:

 Patients undergo cardiac-sparing whole lung IMRT.

 After completion of study treatment, patients are followed up for 1-5 years.
Inclusion Criteria:

 -  Patients may have a Wilms tumor, Ewing Sarcoma, Rhabdomyosarcoma or any other
 metastatic pediatric malignancy; patients may have a single or multiple pulmonary
 metastases at the time of diagnosis or at the time of recurrence; a pulmonary
 metastasis may be defined as one pulmonary nodule >= 1 cm or more than one pulmonary
 nodules >= 0.5 cm; a biopsy of the nodules may be considered in case of doubt

 -  The Karnofsky performance status must be >= 50 for patients > 16 years of age and the
 Lansky performance status must be >= 50 for patients =< 16 years of age

 -  Patients must not have received prior radiation therapy to any part of the thorax

 -  Adequate cardiac function defined as:

 -  Shortening fraction of >= 27% by echocardiogram, or

 -  Ejection fraction of >= 50% by radionuclide angiogram

 -  Female patients of childbearing age must have a negative pregnancy test

 -  Female patients who are lactating must agree to stop breast-feeding

 -  Sexually active patients of childbearing potential must agree to use effective
 contraception

 Exclusion Criteria:

 -  Patients enrolled on Children's Oncology Group protocols cannot be treated with whole
 lung IMRT on this study

 -  Patients who have a prior history of radiation therapy to the thorax or adjacent
 regions cannot be entered on this protocol

 -  Patient with Hodgkin's Lymphoma are not eligible for this study

 -  Patients with mediastinal masses or other pulmonary masses requiring additional
 mediastinal or lung irradiation beyond the whole lung irradiation (WLI) doses stated
 in this protocol are ineligible for this study

 -  Patients who may require concurrent or sequential irradiation to sites beyond the
 chest such as the neck, flank, abdomen or liver are eligible for this study