LaGRA Trial in Laparoscopic Cholecystectomy
LaGRA Trial in Laparoscopic Cholecystectomy
This study investigated the effectiveness of a surgeon administered, laparoscopic guided,
 regional anaesthesia technique.
A prospective, double blind, randomised controlled trial was performed. Consenting patients
 undergoing laparoscopic cholecystectomy were randomised, by envelope, to a laparoscopic
 guided 2-point blockade (subcostal transversus abdominis plane and rectus sheath) using
 either Chirocaine® 2.5mg/ml (LaGRA) or 0.9% Saline (Placebo) after specimen extraction.

 Primary endpoints were post-operative pain in the first 6 hours. Secondary endpoints were
 analgesic/anti-emetic usage and day case and re-admission rates. Data was analysed using
 GraphPad Prism (V7).
Inclusion Criteria:

 -  Patients undergoing laparoscopic cholecystectomy

 -  ASA I, II or III

 Exclusion Criteria:

 -  Patients that don't consent to be included

 -  Allergy to levobupivacaine