Pyrotinib Plus Vinorelbine in Participants With HER2-positive Previously Treated Locally Advanced or Metastatic Breast Cancer
Pyrotinib Plus Vinorelbine in Participants With HER2-positive Previously Treated Locally Advanced or Metastatic Breast Cancer
The purpose of this study is to identify the highest tolerable dose of pyrotinib in
 combination with vinorelbine and to assess the safety and efficacy of the combination in
 Patients With HER2-Positive Locally Advanced or Metastatic Breast Cancer.

 The study will be conducted in two parts. In the first part, testing will be done on up to 12
 subjects to determine the highest tolerable dose of pyrotinib and vinorelbine in patients
 with advanced solid tumors. In the second part of the study, we will explore the safety and
 efficacy of Pyrotinib + vinorelbine in Patients With HER2-Positive Locally Advanced or
 Metastatic Breast Cancer Who Have Received Prior Trastuzumab-Based Therapy. Participants will
 be treated until disease progression (PD), unmanageable toxicity, or study termination.
Inclusion Criteria:

 -  Histologically or cytologically confirmed invasive breast cancer

 -  HER2 status must be prospectively, centrally tested and be HER2-positive based on
 central laboratory assay results

 -  Prior treatment for breast cancer in the adjuvant, unresectable, locally advanced, or
 metastatic setting must include both a taxane, alone or in combination with another
 agent, and trastuzumab, alone or in combination with another agent. Patients who have
 previously used pertuzumab will be allowed.

 -  Documented progression (which occur during or after most recent treatment or within 6
 months after completing of adjuvant therapy) of incurable, unresectable, locally
 advanced or metastatic breast cancer, defined by the investigator

 -  Measurable and/or nonmeasurable disease; participants with central nervous system-only
 disease are excluded

 -  Cardiac ejection fraction greater than or equal to (>/=) 50 percent (%) by either
 echocardiogram or multi-gated acquisition scan

 -  Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1

 Exclusion Criteria:

 -  History of treatment with pyrotinib

 -  Prior treatment with lapatinib or neratinib

 -  History of other malignancy within the last 5 years, except for appropriately treated
 carcinoma in situ of the cervix, non-melanoma skin carcinoma

 -  History of receiving any anti-cancer drug/biologic or investigational treatment within
 28 days prior to randomization except hormone therapy

 -  Recovery of treatment-related toxicity consistent with other eligibility criteria

 -  History of radiation therapy within 28 days of randomization

 -  Brain metastases that are untreated, symptomatic, or require therapy to control
 symptoms, as well as any history of radiation, surgery, or other therapy, including
 steroids, to control symptoms from brain metastases within 2 months (60 days) of
 randomization

 -  History of symptomatic congestive heart failure or serious cardiac arrhythmia
 requiring treatment

 -  History of myocardial infarction or unstable angina

 -  Current severe, uncontrolled systemic disease (for example, clinically significant
 cardiovascular, pulmonary, or metabolic disease)

 -  Pregnancy or lactation

 -  Current known active infection with human immunodeficiency virus (HIV) or hepatitis C
 virus

 -  Presence of conditions that could affect gastrointestinal absorption: Malabsorption
 syndrome, resection of the small bowel or stomach, and ulcerative colitis