Stress Response Pathways in Vitiligo
Stress Response Pathways in Vitiligo
The purpose of this study is to investigate stress response pathways in tissues and
 melanocytes from patients with vitiligo. Investigators are collecting evidence of UPR and
 stress response activation in tissues and melanocytes from patients with vitiligo.
 Individuals with vitiligo will have punch biopsies to study stress response UPR activation
 and NF-κB signaling to test our hypothesis. In order to characterize differences between
 disease and normal states, a second arm of control individuals (Arm 2) will be recruited.
Identifying a role for NF-κB signaling in vitiligo may improve therapies for this disfiguring
 disorder. Current treatments vary in effectiveness and may not always be long lasting cases.
 The NF-κB pathway and IL-6 itself are the target of several FDA approved drugs, thus opening
 new therapeutic avenues.
Inclusion Criteria:

 -  To be eligible for participation, subjects must meet all of the following criteria:

 -  Must have a clinical exam consistent with and diagnosis of non-segmental vitiligo

 -  Must be normally pigmented

 -  No clinical presentation of vitiligo

 Exclusion Criteria:

 -  Outside of the specified age range

 -  No clinical diagnosis of vitiligo

 -  Use of systemic therapies, including but not limited to methotrexate, etretinate, or
 cyclosporine, calcineurin inhibitors and/ or vitamin D analogs within 4 weeks of
 enrollment

 -  Use of topical steroids or topical immunodilators at biopsy site within 4 weeks of
 enrollment

 -  History of keloids or hypertrophic scars

 -  Patients with pacemakers or defibrillators or heart valves

 -  Patients on Plavix, Warfarin or similar anticoagulation medicine

 -  Pregnant females

 -  Lactating women

 -  Allergies or sensitivity to lidocaine or epinephrine

 -  Outside of the specified age range

 -  Abnormally pigmented at potential biopsy sites (non-vitiligo)

 -  Clinical presentation of vitiligo

 -  Use of systemic therapies, including but not limited to methotrexate, etretinate, or
 cyclosporine, calcineuron inhibitors and/ or vitamin D analogs within 4 weeks of
 enrollment

 -  Use of topical steroids or topical immunodilators at biopsy site within 4 weeks of
 enrollment

 -  History of keloids or hypertrophic scars