PEARL Intervention to Reduce Depression Among Adults With Epilepsy
PEARL Intervention to Reduce Depression Among Adults With Epilepsy
The purpose of this study is to test the effectiveness of a home-based depression treatment
 intervention called "Program to Encourage Active, Rewarding Lives (PEARL)". We hypothesize
 that over a 12-month period, compared to usual care, those receiving the PEARL intervention
 will show more improvement with their depression, have higher quality of life and function,
 and use fewer medical services.
Compared to non-depressed individuals with epilepsy, those with depression have significantly
 higher rates of suicide, lower social and occupational functioning, decreased quality of life
 independent of seizure frequency, and higher non-psychiatric health care utilization. Adults
 with epilepsy are more likely to be homebound as a result of reduced function and
 restrictions in driving, opportunities to obtain enhanced quality of care for depression may
 be limited. This study tests the effectiveness of a home-based multi-modal depression
 treatment intervention called Program to Encourage Active, Rewarding Lives (PEARL). PEARL
 consists of problem solving treatment, social and physical activation, pleasant events
 scheduling, support and education regarding antidepressant medication use as well as
 psychiatric consultation and recommendations regarding initiation or adjustment of
 antidepressant medications.

 In a sample of adults with epilepsy who have minor depression, major depression and/or
 dysthymia, we hypothesize that over a 12-month period, compared to usual care, those
 randomized to the PEARL intervention will: achieve higher levels of depression response and
 remission, achieve higher quality of life and function, and utilize less non-psychiatric
 health care.

 By providing a multi-modal, home-based stepped collaborative care intervention for adults
 with depression and epilepsy, this program will offer practical alternatives to usual care
 and will provide a program for improving depression outcomes, quality of life and
 potentially, epilepsy outcomes.
Inclusion Criteria:

 -  Home address within 30 miles of Seattle

 -  Diagnosis of epilepsy (ICD-9 code 345.XX)

 -  Appointment in the UW REC or Neurology clinic in the past 2 years and currently
 enrolled in this clinic.

 -  Current age older than 18 years

 -  Diagnosis of major depression, minor depression or dysthymia

 -  Ability to speak/read English

 Exclusion Criteria:

 -  Alcohol and/or substance abuse/dependence based on a score greater than 1 on 4-item
 validated CAGE-AID

 -  Cognitive impairment based on a score less than 3 on a 6-item validated cognitive
 screen

 -  Diagnosis of bipolar disorder, schizophrenia/schizoaffective disorder or other
 psychotic disorder

 -  Women who are pregnant or nursing

 -  Terminal medical illness

 -  Those currently seeing or planning to see a psychiatrist

 -  Those with suicidal ideation nearly every day