Assessment of Candidate Protein Expression in Breast Cancer Specimens
Assessment of Candidate Protein Expression in Breast Cancer Specimens
RATIONALE: Studying the genes expressed in samples of tumor tissue from patients with cancer
 may help doctors identify biomarkers related to cancer.

 PURPOSE: This research study is looking at tumor tissue samples from patients who have
 undergone surgery for breast cancer.
OBJECTIVES:

 -  To determine if candidate genes display differential expression between normal and
 cancer breast tissues.

 OUTLINE: Previously collected breast cancer tissue samples (paraffin embedded blocks) and
 normal adjacent tissue are used for immunohistochemistry studies of expression of candidate
 genes.
Inclusion Criteria:

 DISEASE CHARACTERISTICS:

 -  Diagnosis of breast cancer

 -  Tissue samples available

 -  Samples are selected based on presence or absence of tumor receptors, (i.e.; estrogen,
 progesterone, and HER2 receptors) and grouped into following 4 categories:

 -  Estrogen receptor (ER)-positive/progesterone receptor (PR)-positive/HER2-negative

 -  ER-positive/PR-positive/ HER2-positive by FISH

 -  ER-negative/PR-negative/HER2-positive

 -  ER-negative/PR-negative/HER2-negative(triple negative or basal-type cancers)

 PATIENT CHARACTERISTICS:

 -  Menopausal status not specified

 PRIOR CONCURRENT THERAPY:

 -  Not specified

 Exclusion Criteria:

 -  There are no exclusion criteria in this protocol