Thermal Screening for Early Diabetic Peripheral Neuropathy (DPN)
Thermal Screening for Early Diabetic Peripheral Neuropathy (DPN)
The goal of this research is to develop better tools for diagnosing illness of the feet and
 legs of people who have diabetes. Investigators will use thermal videos of the foot to aid in
 the refinement of a system designed to detect signs of diabetic peripheral neuropathy (DPN).
 The team of investigators will also look at diabetic eye disease and how it might relate to
 diabetic foot disease.
This study focuses on further development and testing of a microvascular functional imaging
 system, a computer-based system for screening thermal video images, designed to detect
 biomarkers of diabetic peripheral neuropathy (DPN). Additionally, severity levels of diabetic
 retinopathy (DR) will be compared with those of DPN.

 All participants in this study will undergo foot exams, thermal imaging of the foot, and
 standard retinal imaging. These non-invasive assessments will be performed at an initial
 study visit. Some of the participants will be offered additional study visits. One of the
 additional visits involves a standard nerve conduction velocity assessment by a neurologist,
 the other involves a DPN exam by a podiatrist.

 Portions of the study take place at University of New Mexico Health Sciences Center (UNM
 HSC). The research utilizes services of the Clinical Translational Science Center (CTSC).

 The study is approved by University of New Mexico Health Sciences Center's Human Research
 Review Committee (HRRC), which coordinates and supports the activities of the three federally
 mandated Human Research Review Committees (HRRCs) responsible for reviewing and approving all
 human research.
Inclusion Criteria:

 • Must be non-diabetic or diagnosed as diabetic for at least 5 years

 Exclusion Criteria:

 history of chemotherapy

 -  surgery below the knee within the last 2 years

 -  fractures below the know within the last 2 years

 -  history of stroke

 -  body mass index (BMI) greater than 35

 -  history of heart failure

 -  peacemaker or implantable cardiovascular defibrillator

 -  high blood pressure (over 180/100)

 -  end-stage renal (kidney) disease or renal (kidney) transplant

 -  peripheral edema greater than 2+ (swelling of the feet or hands)

 -  diabetic foot ulcers

 -  foot sores

 -  Raynaud's phenomenon

 -  tobacco use within the last month.

 -  treatment with glucocorticoids, including:

 -  beclomethasone

 -  betamethasone

 -  budesonide

 -  cortisone

 -  dexamethasone

 -  hydrocortisone

 -  methylprednisolone

 -  prednisolone

 -  prednisone

 -  triamcinolone