Impact of Platinum-based Cancer Treatment on Endothelial Function
Impact of Platinum-based Cancer Treatment on Endothelial Function
In this research we investigate endothelial function in cancer patients who received platinum
 based chemotherapy.
The goal of the study is to evaluate endothelial function in patients with platinum-based
 versus non-platinum-based chemotherapy.

 Endothelial function was evaluated via Angioscan( the apparatus that evaluate the stiffness
 of vessels by pulse wave velocity) and serum levels of endothelial nitric oxide synthase
 (ENOS),endothelin1.

 Patients with gastrointestinal, ovarian, bladder and brest cancer would be included.

 Patients with malignancies were followed-up from 2 weeks to 3 month after start of
 chemotherapy, Medical records and hospital databases were searched for all the patients
 treated with different chemotherapy treatment for any kind of cancer.
Inclusion Criteria:

 -  Subject has solid cancer

 -  Subject is expected to start chemotherapy

 Exclusion Criteria:

 -  Pregnancy and lactation

 -  Severe impaired kidney function

 -  Severe hepatic impairment

 -  Mental disease

 -  Acute myocardial infarction 28 days ago or earlier

 -  Acute Cerebrovascular Event 1 month ago or earlier

 -  Rhythm disturbance that complicate pulse wave velocity evaluation