Risk of Diabetes in Young Turner Syndrome Patients
Risk of Diabetes in Young Turner Syndrome Patients
Turner Syndrome is a common genetic disorder. Seventy percent of adults with Turner Syndrome
 have abnormalities in glucose metabolism which can lead to diabetes. The current screening
 guidelines for diabetes in Turner Syndrome are not specific and involve a fasting blood sugar
 once a year. The objective of this study is to determine if there are abnormalities in
 glucose metabolism and pancreatic function in young girls with Turner Syndrome. The study
 hypothesis is that pancreatic dysfunction (specifically of the beta cells that make insulin)
 is more prevalent in girls with Turner Syndrome compared to healthy controls.
The study will be conducted at Children's Hospital Medical Center, Cincinnati. The study will
 require 1 visit to the hospital where the subject will have an oral glucose tolerance test
 and a physical exam
Turner Syndrome Females:

 Inclusion Criteria:

 -  Turner Syndrome confirmed by chromosomal testing

 -  On standard therapy (growth hormone and or estrogen)

 Exclusion Criteria:

 -  Type 1 or Type 2 diabetes

 -  Polycystic Ovarian Syndrome

 -  Pregnancy

 -  On any medications that alter blood sugar

 Healthy Female Controls:

 Inclusion Criteria:

 -  Healthy

 Exclusion Criteria:

 -  Type 1 or Type 2 diabetes

 -  Polycystic Ovarian Syndrome

 -  Pregnancy

 -  On any medications that alter blood sugar