Thyroid Hormone Dose Adjustment in Pregnancy
Thyroid Hormone Dose Adjustment in Pregnancy
Our aim is to compare the safety and efficacy of 2 different empiric levothyroxine dose
 adjustment recommendations to be made at the first confirmation of pregnancy in women with a
 history of hypothyroidism. Subjects will be women with a prior diagnosis of hypothyroidism
 who are taking thyroid hormone replacement and who are less than 8 weeks pregnant. Upon
 confirmation of pregnancy, subjects will be randomized to increase their weekly thyroid
 hormone dose by either 2 or 3 tablets (28 or 42%). Thyroid function will be evaluated every
 two weeks in the first 20 weeks and then again at week 30 and post-partum. Primary endpoints
 will be the proportion of women in each group who remain euthyroid throughout the first
 trimester and throughout pregnancy.
Our aim is to compare the safety and efficacy of 2 different empiric levothyroxine dose
 adjustment recommendations to be made at the first confirmation of pregnancy in women with a
 history of hypothyroidism. Subjects will be women with a prior diagnosis of hypothyroidism
 who are taking thyroid hormone replacement and who are less than 8 weeks pregnant. Upon
 confirmation of pregnancy, subjects will be randomized to increase their weekly thyroid
 hormone dose by either 2 or 3 tablets (28 or 42%). Thyroid function will be evaluated every
 two weeks in the first 20 weeks and then again at week 30 and post-partum. Primary endpoints
 will be the proportion of women in each group who remain euthyroid throughout the first
 trimester and throughout pregnancy
Inclusion Criteria:

 -  women with a prior diagnosis of hypothyroidism, currently receiving levothyroxine
 therapy

 -  less than 8 weeks pregnant

 Exclusion Criteria:

 -  cardiac disease, renal failure

 -  not euthyroid biochemically within 6 months pre-pregnancy