MMRF Molecular Profiling Protocol
MMRF Molecular Profiling Protocol
Here we propose an "integrative sequencing approach" utilizing a 1500 gene exome comparative
 analysis between multiple myeloma or related plasma cell malignancies and normal cells
 coupled to capture transcriptome sequencing to provide a nearly comprehensive landscape of
 the genetic alterations for the purpose of identifying informative and/or actionable
 mutations in patients with multiple myeloma and plasma cell malignancies. The approach will
 enable the detection of point mutations, insertions/deletions, gene fusions and
 rearrangements, amplifications/deletions, and outlier expressed genes among other classes of
 alterations.
Inclusion Criteria:

 1. Patients must have a diagnosis of multiple myeloma or related malignancy

 2. Patients are undergoing standard of care bone marrow aspirates

 3. Patients (male or female) from any race or ethnicity must be at least 18 years of age
 at the time of registration.

 4. Procedure-specific signed informed consent form prior to initiation of any
 study-related procedures.

 Exclusion Criteria:

 1. It is the enrolling study physician's discretion to decide if a patient is not fit
 enough to undergo a bone marrow aspirate.

 2. Patients who are incarcerated are not eligible to participate.

 3. Women who are pregnant

 4. Patients who have had another malignancy within the last five (5) years (except for
 basal or squamous cell carcinoma, or in situ cancer of the cervix) where there is a
 possibility to contaminate the bone marrow aspirate.