Multidisciplinary Treatment of Obesity Prior to in Vitro Fertilization: Impact on Global Reproductive Outcomes (PRO-FIV Study)
Multidisciplinary Treatment of Obesity Prior to in Vitro Fertilization: Impact on Global Reproductive Outcomes (PRO-FIV Study)
The aim of the present study is to evaluate the impact of a multidisciplinary treatment of
 obesity prior to IVF on global reproductive outcomes and maternofetal metabolic and
 cardiovascular risk factors.

 This is a randomized controlled trial in obese infertile women before starting an IVF cycle.
 The intervention is based on a structured multidisciplinary program in support groups, which
 includes diet, physical activity and psychological therapy. IVF will be started immediately
 after this therapy. Patients included in the control group will start an IVF cycle
 immediately after the randomization. The results of this study may allow the identification
 of patients who would benefit from obesity treatment, so as to establish appropriate
 preventive and therapeutic strategies and to reduce the maternal obesity impact in future
 generations.
The aim of the present study is to evaluate the impact of a multidisciplinary treatment of
 obesity prior to IVF on global reproductive outcomes and maternofetal metabolic and
 cardiovascular risk factors.

 This is a randomized controlled trial in obese infertile women (body mass index ≥30 kg/m2)
 before starting an IVF cycle. In the intervention group, the aim is a weight loss of at least
 10% in a 16-week period of treatment based on a multidisciplinary approach and support
 groups, which includes diet, physical activity and psychological therapy. IVF will be started
 immediately after this period. Patients included in the control group will start an IVF cycle
 immediately after the randomization. The results of this study may allow the identification
 of patients who would benefit from obesity treatment, so as to establish appropriate
 preventive and therapeutic strategies and to reduce the maternal obesity impact in future
 generations.
Inclusion Criteria:

 -  Obese infertile patients (body mass index ≥ 30 Kg/m2) prior to an in vitro
 fertilization cycle

 Exclusion Criteria:

 -  Pathological conditions: diabetes type I, Cushing syndrome, premature ovarian failure,
 uncontrolled thyroidal dysfunction, hepatic and/or renal dysfunction, antiphospholipid
 syndrome, medical condition that contraindicate ovarian stimulation and/or pregnancy

 -  Simultaneous practice of another strategy to lose weight

 -  Physical conditions limiting exercise training

 -  Patients unable to understand spanish language or to give informed consent