Complement Activation During Hemodialysis in Atypical Hemolytic Uraemic Syndrome as Underlying Kidney Disease
Complement Activation During Hemodialysis in Atypical Hemolytic Uraemic Syndrome as Underlying Kidney Disease
Atypical hemolytic uraemic syndrome is caused by defects in the regulating factors in the
 alternative pathway of the complement system. Triggering can cause an uncontrolled complement
 activation with endothelial damage and thrombotic micro-angiopathy, especially in the
 kidneys. This can result in endstage renal failure. Complement activation during hemodialysis
 has been described as a result of contact between blood and the dialysis membrane. Our
 hypothesis is that patients with atypical hemolytic uraemic syndrome have a stronger
 complement activation during hemodialysis than patients with another underlying kidney
 disease. This could be a reason to treat patients with endstage renal failure due to atypical
 hemolytic uraemic syndrome preferentially with peritoneal dialysis instead of hemodialysis.
Inclusion Criteria:

 -  cases: endstage renal failure due to atypical hemolytic uraemic syndrome treated with
 hemodialysis.

 -  controls: endstage renal failure due to a non complement consuming nephropathy treated
 with hemodialysis.