Anterior Prolapse Repair With and Without Graft Augmentation
Anterior Prolapse Repair With and Without Graft Augmentation
This is a randomized control trial comparing anterior colporrhaphy with augmentation with
 dermal allograft (ARCUS) to anterior colporrhaphy with a suture-based repair (native tissue).
 Patients were randomized to one treatment and then were followed post-operatively for 7-10
 years. Prior to surgery patients had a POPQ vaginal prolapse exam and completed a quality of
 life questionaire (PFDI). They had a repeat POPQ exam and quality of life questionaires at
 their post-op operative visits. We compare recurrent prolapse rates between these 2 groups.
Objective: To determine whether dermal allograft (ARCUS) reduces anterior prolapse recurrence
 at 1 and 7-10 years post-operatively. Our central question is whether we can reduce the rate
 of rate of anterior compartment prolapse recurrence after surgical repair, is the recurrence
 rate reduced with allograft use, and does this benefit hold up over time?

 Methods: Patient will be randomized by computer generated block randomization to native
 tissue (suture based) anterior colporrhaphy or colporrhaphy with graft (ARCUS) usage. Neither
 patients nor surgeons will be blinded due to the nature of the surgery. Patients will be
 followed for 7-10 years post-operatively. Participants will complete a POPQ exam and the PFDI
 (Pelvic Floor Distress Inventory) questionnaire pre-operatively. Patients will return for a
 POPQ exam at 1 year post-operatively and complete the PFDI (Pelvic Floor Distress Inventory)
 and PISQ (Sexual Function for Women with: POP, Urinary Incontinence and/or Fecal
 Incontinence) questionnaires. Patients will be asked to return to the office for a research
 visit 7-10 years post-operatively for a POPQ exam and to complete quality of life
 questionnaires including PFDI 20 (Pelvic floor distress inventory), PISQ-R (Sexual Function
 for Women with: POP, Urinary Incontinence and/or Fecal Incontinence, Revised), and PGI
 (Patient global assessment of improvement).
Inclusion Criteria: Any patient planning to undergo surgery for anterior compartment
 prolapse, English speaking.

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 Exclusion Criteria: Any patient who does not speak English due to standardized English
 language based questionaires, and patients without anterior compartment prolapse.

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