Autoimmune Encephalitis With Anti-NMDA Receptor Antibodies Following Herpetic Encephalitis
Autoimmune Encephalitis With Anti-NMDA Receptor Antibodies Following Herpetic Encephalitis
Herpes Simplex Virus encephalitis is the most common infectious encephalitis, with an
 estimated annual incidence of 1 / 250,000 to 1 / 500,000 in industrialized countries. Despite
 a widely used antiviral treatment, the prognosis remains poor with a mortality of 5 to 20%
 and a considerable morbidity rate.

 One of the contributing factors of bad prognosis is the development of encephalitis mediated
 by autoantibodies, most often directed against NMDA receptors, in the weeks following viral
 encephalitis.

 The description of this pathology is recent, the pathophysiology of this process remains
 poorly understood, and the management of these patients is not yet codified.
Inclusion Criteria:

 -  Clinical autoimmune encephalitis with anti-NMDA antibodies and documented by CBA in
 the CSF

 -  After a herpetic encephalitis documented by a positive viral PCR for HSV in the CSF

 -  Without age limit

 Exclusion Criteria- No respect of inclusion criteria