Sentinel Node Biopsy Vs Observation After Axillary PET
Sentinel Node Biopsy Vs Observation After Axillary PET
Several researches have proved that avoiding axillary surgery does not worsen the outcome of
 breast cancer patients with relatively low risk. Based on the routine axillary imaging
 evaluation (ultrasound and MR etc.) and latest dedicate lymph node PET (LymphPET), axillary
 nodal burden can be identified before operation.

 Therefore this prospective study are designed to evaluate the negative predictive value of
 LymphPET and to verify whether sentinel lymph node biopsy can be spared in patients with
 negative preoperative axillary assessment.
Inclusion Criteria:

 stage 1:

 1. female

 2. ≥18 years old

 3. invasive ductal carcinoma or DCIS proved by core needle biopsy

 4. tumor size ≤ 5cm

 5. negative preoperative axillary assessment(including body examination, ultrasound and
 MR examination)

 6. patients is accessible for the following axillary surgery and pathological
 test(including sentinel lymph node biopsy and axillary lymph node dissection)

 stage 2:

 1. female

 2. ≥18 years old

 3. invasive carcinoma proved by core needle biopsy

 4. has plan for breast conserving surgery and adjuvant radiation after surgery

 5. negative preoperative axillary assessment(including body examination, ultrasound and
 axillary PET mSUV<0.27)

 6. patients is accessible for the follow up

 Exclusion Criteria:

 stage 1:

 1. distant metastases

 2. in the procedure of neoadjuvant therapy

 3. positive preoperative axillary assessment (including body examination, ultrasound and
 MR examination)

 4. pregnancy or breastfeeding

 5. axillary biopsy or axillary surgery before LymphPET

 6. suffer from diabetes mellitus and without well control of bloodglucose

 7. previous malignancy

 8. allergic to tracer of LymphPET

 stage 2:

 1. distant metastases

 2. in the procedure of neoadjuvant therapy

 3. positive preoperative axillary assessment (including body examination, ultrasound and
 PET mSUV≥0.27)

 4. pregnancy or breastfeeding

 5. axillary biopsy or axillary surgery before LymphPET

 6. suffer from diabetes mellitus and without well control of bloodglucose

 7. previous malignancy

 8. allergic to tracer of LymphPET