Insulin Detemir Action in Cerebro
Insulin Detemir Action in Cerebro
The aim of this study is to test the hypothesis that subcutaneous administration of insulin
 detemir, as compared to insulin NPH, leads to a more pronounced effect on cerebral glucose
 metabolism and/or cerebral blood flow in brain regions associated with appetite regulation,
 to account for the reported difference in weight.
Inclusion Criteria:

 -  Type 1 diabetic patients;

 -  Diabetes duration =/> 1 year;

 -  HbA1c ~ 7,5%;

 Exclusion Criteria:

 -  Recent onset of DM;

 -  BMI < 18 OR > 35 kg/m2;

 -  T2DM;

 -  History of major heart/renal disease;

 -  Severe untreated proliferative retinopathy;

 -  History of recurrent severe hypoglycaemia;

 -  (History of) brain disorders;

 -  Alcohol abuse,(History of) drug abuse, benzodiazepines, selective beta-blockers, oral
 steroids, oral anticoagulants;

 -  Current psychiatric disease/treatment;

 -  (history of) eating disorders;

 -  History of severe head trauma accompanied by loss of consciousness;

 -  Any endocrine disease not well controlled for at least 3 months;

 -  Inability to undergo MRI;

 -  Visual acuity < 0.3;

 -  Known or suspected allergy to trial product or related products