Effects of Low FODMAP Diet on Leaky Gut
Effects of Low FODMAP Diet on Leaky Gut
The pathophysiology of Irritable bowel syndrome (IBS) is multifactorial involving complex
 interplay of altered intestinal permeability, mucosal immune activation, visceral
 hypersensitivity and gut dysbiosis. Although the exact triggers for these pathological
 changes in IBS are not clear but diet might play an important role. In fact, several studies
 have reported improvement in gastrointestinal symptoms on a diet low in FODMAPs (LFD) in
 patients with IBS, specifically in diarrhea predominant IBS (IBS-D). However, the mechanism
 of action of LFD is not well understood.
Inclusion Criteria:

 -  aged 18-65 years at the time of screening

 -  normal serum studies including serum tissue-transglutaminase antibodies, thyroid
 stimulating hormone levels, C-reactive protein, complete blood count since the onset
 of symptoms

 -  normal stool studies including C diff testing, culture, ova and parasites since the
 onset of symptoms

 -  IBS-SSS score of ≥175 at the end of 7-day screening period

 Exclusion criteria:

 -  individuals already on a LFD or other dietary restriction such as gluten free diet
 within the past 6 months

 -  individuals with any known food allergy or insulin-dependent diabetes

 -  known history of celiac disease, inflammatory bowel disease or microscopic colitis

 -  prior small bowel or colonic surgery or cholecystectomy

 -  pregnant patients

 -  antibiotics in the past 3 months

 -  those who regularly use mast cell stabilizers or anti-histaminic or non-steroidal
 anti-inflammatory agents (NSAIDs) excluding daily baby aspirin or steroids or
 bile-acid binder.