As Study of the Pharmacokinetics of Paliperidone Extended-release and Risperidone Immediate-release Formulations
As Study of the Pharmacokinetics of Paliperidone Extended-release and Risperidone Immediate-release Formulations
The purpose of this study is to compare the steady-state pharmacokinetics of paliperidone
 after oral administration of 15 mg extended-release (ER) OROS paliperidone once daily with
 the steady-state pharmacokinetics of paliperidone after oral administration of 8 mg
 immediate-release (IR) risperidone twice daily; and to explore the dose-proportionality of 9
 mg and 15 mg ER OROS paliperidone. Other objectives are to 1) document the disposition of the
 enantiomers of paliperidone; 2) explore the relationship between genotype (CYP2D6, CYP3A4,
 CYP3A5, UGT1A1, and UGT1A6) and pharmacokinetic parameters; and 3) assess safety and
 tolerability.
This is an open-label, multiple-dose, parallel-group study in patients with schizophrenia or
 schizoaffective disorder. The study consists of a screening period (2 weeks maximum); a
 1-week run-in or washout (Days 1 to 7) during which patients taking risperidone prestudy and
 randomly assigned to paliperidone treatment will receive replacement antipsychotic therapy,
 and other patients continue to take their prestudy antipsychotic medication; a 14-day
 open-label treatment period (Days 8 to 21); and a 5-day follow-up period. On Day 1 of the
 washout period, eligible patients will be randomized to receive ER OROS paliperidone (PAL) or
 risperidone (RIS). All patients will receive their first dose of study medication on Day 8
 after randomization as follows: Patients randomized to PAL will receive 9 mg of ER OROS
 paliperidone daily from Day 8 to Day 14, followed by 15 mg of ER OROS paliperidone q.d. from
 Day 15 to Day 21. Patients randomized to RIS will receive dose-escalation up to 7 mg
 risperidone twice daily (b.i.d.) from Day 8 to Day 14, followed by 8 mg risperidone b.i.d.
 from Day 15 to Day 21. The study medication on Days 14 and 21 in the PAL group and on Day 21
 in the RIS group will be administered after completion of a standardized high fat, high
 caloric breakfast. Patients will be confined to the testing facility from the morning of Day
 8 (or earlier at the discretion of the investigator) until completion of the study procedures
 on Day 23. On all other assessment days, patients will return to the testing facility and
 remain there for the duration of the assessments.The highest dose of paliperidone currently
 being studied is 12 mg given as 6 tablets of 2 mg ER OROS paliperidone. In the currently
 proposed study, data on the safety and tolerability of the 15-mg dose will be monitored and
 collected. Paliperidone ER oral administration of 9 mg q.d. on Day 8 to 14, and 15 mg daily
 on Day 15 to 21; oral administration of escalating doses up to 7 mg risperidone twice daily
 (b.i.d.) between Days 8 and 14, inclusive, and 8 mg risperidone b.i.d. on Day 15 to 21
Inclusion Criteria:

 -  Currently treated with a dose of at least 6 mg of risperidone daily or the equivalent
 of any other antipsychotic medication or a combination thereof (an equivalence table
 will be provided to the sites)

 -  Has a DSM-IV diagnosis of schizophrenia (295.10, 295.20, 295.30, 295.60, 295.90) or
 schizoaffective disorder

 -  Healthy on the basis of a prestudy physical exam, medical history, ECG, and laboratory
 results of blood biochemistry, hematology, and urinalysis performed within 2 weeks of
 randomization. If the results of the biochemistry or hematology tests or the
 urinalysis are not within the laboratory's reference ranges the patient can be
 included only if the investigator judges that the deviations are not clinically
 significant. For liver function tests (alanine transaminase, aspartate transaminase,
 and bilirubin), the values must be contained within 2 times the upper limits of the
 normal laboratory reference ranges and for renal function tests, the values must be
 within the normal laboratory reference ranges

 -  Women must be postmenopausal for at least 1 year, surgically sterile, or practicing an
 effective method of birth control (e.g., prescription oral contraceptives,
 contraceptive injections, intrauterine device, double-barrier method, contraceptive
 patch, male partner sterilization and at the discretion of the investigator, total
 abstinence) before entry and throughout the study, as well as have a negative serum
 pregnancy test at screening. To ensure continued eligibility, women must have a
 negative urine test at baseline

 -  Body weight as defined by body mass index (weight [kg]/height (m)²) within a range of
 15.0 to 35.0 kg/m², inclusive

 -  Willingness to spend 15 days as an in-patient during the treatment period

 -  Normotensive at screening, with supine (5 minutes) blood pressure between the range of
 100 to 140 mmHg systolic, inclusive, and 60 to 90 mmHg diastolic, inclusive.

 Exclusion Criteria:

 -  Involuntarily committed in-patients

 -  Has a DSM-IV diagnosis of substance dependence within 3 months before screening
 evaluation. Nicotine and caffeine dependence and history of recreational use of
 marijuana are not exclusionary

 -  At screening, has a decrease of > = 20 mmHg systolic blood pressure or a decrease of >
 =10 mmHg decrease in diastolic blood pressure 2 minutes after standing, or experience
 symptoms of lightheadedness, dizziness, or fainting upon standing

 -  orthostatic hypotension

 -  Tests positive for the urine drug screen at screening

 -  Had an acute exacerbation of psychotic symptoms within the last 3 months before screen

 -  Relevant history or current presence of any cardiovascular, respiratory, central
 nervous system, neuropsychiatric (including seizures), renal, hepatic, endocrine, or
 immunologic diseases

 -  Has a DSM-IV Axis I diagnosis other than schizophrenia or schizoaffective disorder

 -  Suicidal or homicidal ideation