PET-MRI for Functional Imaging of the Testis: A Feasibility Study
PET-MRI for Functional Imaging of the Testis: A Feasibility Study
The primary objective of this study is to explore feasibility of testis functionality
 assessment and testis imaging obtained from Positron Emissions Tomography (PET) /Magnetic
 Resonance Imagine (MRI). Using advanced MRI metrics, investigators will study the
 three-dimensional structure of normal testis, the levels of specific elements and compounds
 in the tissues (which can only be found via these imaging techniques), and the directionality
 (and alterations in directionality) of tissue structure. Investigators hope to develop
 hypothesis that will in turn suggest bio-markers to be explored in subsequent clinical
 trials.
Inclusion Criteria:

 -  Men with proven paternity desiring vasectomy who are over 18 years of age.

 Exclusion Criteria:

 -  Bilaterally absent testes, unilaterally or bilaterally undescended testes

 -  Patients who have proven azoospermia or no proven paternity

 -  Inability to tolerate MRI including conditions such as claustrophobia or inability to
 lay flat for > 45 minutes.

 -  Presence of pacemaker/IImplantable Cardioverter Defibrillator (ICD) or perfusion pumps

 -  Ferromagnetic implants such as aneurysm clips, surgical clips, prostheses, artificial
 heart, valves with steel parts, metal fragments, shrapnel, bullets, tattoos near the
 eye, or steel implants.

 -  Substance abuse, medical, psychological, or social conditions that may interfere with
 the patient's participation in the study

 -  All women are excluded as such patients do not have the relevant anatomy being
 considered in this study

 -  Anyone from a vulnerable population will be excluded from the study