Protocol for Postmenopausal Women at Increased Risk of Developing Breast Cancer
Protocol for Postmenopausal Women at Increased Risk of Developing Breast Cancer
A study to examine the potential associations between common single nucleotide polymorphisms
 and pre-cancerous conditions in breast tissue specimens from postmenopausal women.
A study to examine the correlation between single nucleotide polymorphisms (SNPs) affecting
 steroid and carcinogen metabolism and benign breast tissue cytomorphology collected via
 random periareolar fine needle aspiration in postmenopausal women at increased risk for
 breast cancer and taking hormone replacement therapy.
Inclusion Criteria:

 -  postmenopausal women on or off hormone replacement therapy

 -  at high risk of developing breast cancer determined by family or personal history

 -  postmenopausal women not on hormone replacement therapy for at minimum six months
 prior to corresponding aspiration

 -  willing to participate in companion protocol (KUMC HSC#4601) for random periareolar
 fine needle aspiration (RPFNA) for correlational studies

 Exclusion Criteria:

 -  women who have been on raloxifene, tamoxifen, letrozole, anastrozole or exemestane
 within the six months prior to RPFNA.