Effects of Incretin on the Blood Pressure and Lipid in Patients With Overweight or Obese Diabetes
Effects of Incretin on the Blood Pressure and Lipid in Patients With Overweight or Obese Diabetes
Obesity is one of the characteristics of type 2 diabetes mellitus. Most of the obese diabetes
 patients are combined with dyslipidemia or hypertension. The clustering of diabetes, obesity,
 hypertension and dyslipidemia increases the risk of cardiovascular events for patients. GLP-1
 (glucagon like peptide-1) is a kind of incretin discovered in recent years. It was reported
 that beside its hypoglycemic and losing weight effects, activator of GLP-1 receptor could
 decrease blood pressure and improve lipid metabolism. Therefore, activation of GLP-1 receptor
 may become a new comprehensive treatment strategies for improving glucose and lipid
 metabolism, blood pressure level and cardiovascular complication. But, it is lack of
 evidence-based medicine proof on the relationship between GLP-1 and blood pressure or serum
 lipid. So, investigators designed a prospective, randomized, open-label, active control
 study, and try to evaluate the effects of activator of GLP-1 receptor (liraglutide) on
 lowering blood pressure, improving vascular function and lipid metabolism in overweight or
 obese type 2 diabetic patients with masked hypertension.
Inclusion Criteria:

 1. Male or female, age between 35-60 years old

 2. Type 2 diabetes

 3. 24kg/m²≤BMI≤32kg/m², or WC≥90cm for male and WC≥85cm for female

 4. Grade 1 hypertension or masked hypertension diagnosed via 24-h ambulatory blood
 pressure monitoring (daytime blood pressure load 50%≥135/85 mmHg, night time blood
 pressure load 50%≥125/75 mmHg or 24h blood pressure load 50%≥130/80 mmHg）

 Exclusion Criteria:

 1. Type 2 diabetes with serious complications, such as diabetic neuropathy, diabetic
 retinopathy, stage IV diabetic nephropathy, or acute diabetic complications.

 2. Type 1 diabetes.

 3. Diagnosed moderate to severe sleep apnea syndrome(SAS).

 4. Grade 2 or Grade 3 hypertension.

 5. Triglyceride≥5.65mmol/L

 6. History of cardio-cerebral vascular events such as congestive heart failure,
 myocardial infarction or stroke within 3 months.

 7. Hypohepatia (AST or AST is twice higher than the upper limit) or history of hepatitis
 or cirrhosis, hepatic encephalopathy.

 8. Renal insufficiency ( serum creatinine is 1.5 times higher than the upper limit) or
 history of dialysis and nephritic syndrome.

 9. Chronic obstructive pulmonary disease (COPD), chronic respiratory failure or hyoxemia.

 10. Acute infections, tumor, severe arrhythmia, mental disorders, alcohol or medicine
 addiction.

 11. Fertile woman without contraceptives.

 12. Any surgical or medical conditions that significantly influence absorption,
 distribution, metabolism or excretion of the intervention drugs.

 13. Allergic to or have contraindication to the intervention drugs.