Artificial Pancreas With Different Stress Assessments in the Outpatient Setting
Artificial Pancreas With Different Stress Assessments in the Outpatient Setting
This feasibility study is a randomized crossover trial that will compare the efficacy and
 safety of an automated insulin delivery (AID) system in patients with type 1 diabetes using a
 Model Predictive Control (MPC) algorithm versus sensor augmented pump therapy
 (SAP)/Predictive Low Glucose Suspend (PLGS), and will include different stress induction and
 assessments over a 4 week period.
Eligible participants will be randomly assigned to one of two treatment arms: 1) AID for two
 weeks and SAP/PLGS for two weeks , or 2) SAP/PLGS for two weeks and AID for two weeks. During
 the 4-week trial, subjects will wear the Empatica E4 wristband every day to record
 electrodermal activity, accelerometer and heartrate data. Subjects will also complete
 logbooks to record activity and stress. During each two-week period, subjects will come to
 the clinical center twice for stress induction tests in a medically supervised setting.
Inclusion Criteria:

 -  Clinical diagnosis, based on investigator assessment, of type 1 diabetes for at least
 one year and using insulin for at least 1 year

 -  Using an insulin pump for at least 3 months at the time of screening. Insulin pump use
 includes use of automated features, to include predictive or threshold low-glucose
 suspend or hybrid closed-loop with or without a Dexcom sensor.

 -  Familiarity and use of a carbohydrate ratio for meal boluses.

 -  Age ≥18.0 years old

 -  HbA1c < 10.5%, as performed by point of care or central laboratory testing. HbA1c will
 be assessed at the screening visit, or if already completed within 2 weeks of the
 screening visit, the prior lab value may be used in lieu of repeating this assessment.

 -  For females, not currently known to be pregnant. If female and sexually active, must
 agree to use a form of contraception to prevent pregnancy while a participant in the
 study and up to one month afterwards. A negative serum or urine pregnancy test will be
 required for all females of child-bearing potential. Participants who become pregnant
 will be discontinued from the study. Also, participants who during the study develop
 and express the intention to become pregnant within the timespan of the study will be
 discontinued.

 -  Willingness to switch home pump to PLGS or full manual mode if using hybrid -
 Investigator has confidence that the participant can successfully operate all study
 devices and is capable of adhering to the protocol.

 -  Willingness to switch to lispro (Humalog) or aspart (Novolog) if not using already,
 and to use no other insulin besides lispro (Humalog) or aspart (Novolog) during the
 study.

 -  Willingness not to start any new non-insulin glucose-lowering agent during the course
 of the trial.

 Exclusion Criteria:

 -  Use of an unapproved closed-loop insulin delivery system within 2 weeks before
 screening or during the study is not allowed.

 -  Have a blood pressure at screening outside the range of 160 mmHg systolic blood
 pressure and/or greater than 100 mmHg for diastolic blood pressure (if repeated
 measurements are within this range, the patient may be included in the study)

 -  Have coronary artery disease that is not stable with medical management, including
 unstable angina, angina that prevents moderate exercise despite medical management, or
 within the last 12 months before screening a history of myocardial infarction,
 percutaneous coronary intervention, enzymatic lysis of a presumed coronary occlusion,
 or coronary artery bypass grafting

 -  Concurrent use of Afrezza or any non-insulin glucose-lowering agent other than
 metformin (including GLP-1 agonists, Symlin, DPP-4 inhibitors, SGLT-2 inhibitors,
 sulfonylureas).

 -  Hemophilia or any other bleeding disorder

 -  A condition, which in the opinion of the investigator or designee, would put the
 participant or study at risk, to include:

 -  Pregnancy, or planning pregnancy within 1 month of completing the clinical trial.

 -  Allergy or hypersensitivity to hydrocortisone, or any component of the
 formulation

 -  Presence of a known adrenal disorder

 -  Systemic fungal infections

 -  Active infection of any kind, or at risk of infection (susceptibility to
 infection) from known immunosuppression or underlying immunosuppressed condition

 -  Idiopathic thrombocytopenia purpura (ITP)

 -  Varicella

 -  Glaucoma or other chronic ocular condition that could be adversely affected by
 steroids (e.g., cataracts, increased ocular pressure from other causes,
 exophthalmos)

 -  Hypertension requiring treatment with one or more antihypertensive medications

 -  Congestive heart failure

 -  Current treatment for a seizure disorder

 -  Mental incapacity, unwillingness or language barriers precluding adequate
 understanding or co-operation, including subjects not able to read or write

 -  Known coronary artery disease

 -  Active gastroparesis

 -  Cystic fibrosis

 -  Uncontrolled thyroid disease (TSH undetectable or > 10 mIU/L)

 -  Known abuse of alcohol

 -  A recent injury to body or limb, muscular disorder, use of any medication, any
 carcinogenic disease, or other significant medical disorder if that injury,
 medication or disease in the judgment of the investigator will affect the
 completion of the protocol

 -  Current use of a beta blocker medication

 -  Laboratory results:

 -  HbA1c > 10.5%

 -  Abnormal liver or renal function (Transaminase >2 times the upper limit of
 normal, creatinine> 1.5 mg/dL)

 -  Labs drawn at screening visit or within three months prior to screening (for
 other purposes) will suffice for enrollment purposes

 -  Subject has skin conditions that, in the determination of the investigator, would
 preclude wearing the study devices (infusion set and sensor), in the abdomen.
 Examples include but are not limited to: psoriasis, burns, scaring, eczema,
 tattoos, and significant hypertrophy at sites of device wear; any known allergy
 to medical adhesives.

 -  Currently on long-term treatment using prednisone or other steroid

 -  If subject had been on short term treatment of prednisone, defer enrollment until
 underlying condition and prednisone treatment have resolved.

 -  Allergy to study drug, food or other study material.

 -  Clinically significant physical examination, laboratory test, or vital sign
 abnormality.

 -  Exposure to any investigational drug within 30 days.

 -  History of malignancy within the 5 years before screening (other than basal cell
 carcinoma).

 -  Participation in another pharmaceutical or device trial at the time of enrollment or
 during the study

 -  Having a direct supervisor at place of employment who is also directly involved in
 conducting the clinical trial (as a study investigator, coordinator, etc.); or having
 a first-degree relative who is directly involved in conducting the clinical trial