Use of Human Papillomavirus Persistence for Determination of Treatment Efficacy Among Women With Cervical Dysplasia
Use of Human Papillomavirus Persistence for Determination of Treatment Efficacy Among Women With Cervical Dysplasia
The objectives are to evaluate the effectiveness of treatment of cervical intraepithelial
 neoplasia (CIN) by loop electrosurgical excision procedure using persistence of human
 papillomavirus (HPV) as outcome, and to perform a long-term follow-up on the ability of HPV
 testing, as compared to cytology, to predict recurrence of high-grade CIN.
Cervical samples for human papillomavirus (HPV) DNA analysis and cytological analysis were
 obtained from women with abnormal smears referred to Umeå university hospital, Sweden, for
 treatment with conization. These women were scheduled for HPV DNA testing and Pap smears
 before and 3, 6, 12, 24 and 36 months after treatment. The HPV DNA testing was performed with
 a PCR-based genotyping method.
Inclusion Criteria:

 -  Referral to Umeå university hospital for treatment due to abnormal Pap smear.

 Exclusion Criteria:

 -  Lack of informed consent.