Biologic Mechanisms of Early Exercise After Intracerebral Hemorrhage
Biologic Mechanisms of Early Exercise After Intracerebral Hemorrhage
This study aims to determine whether in-bed cycle ergometry, early in the hospital course
 after a brain hemorrhage could balance damaging and reparative inflammation in the brain.
 Inflammatory factors of two groups of patients with brain hemorrhage will be compared, one
 group will receive in-bed cycling beginning 3 days after hemorrhage plus usual care and the
 other group will receive usual care only.
Inclusion Criteria:

 -  Supratentorial intracerebral hemorrhage with or without intraventricular hemorrhage

 -  Pre-morbid modified Rankin Score of 0-2

 -  Patient must be able to provide informed consent or have a legally authorized
 representative to provide consent on patient's behalf

 Exclusion Criteria:

 -  Patients with known inflammatory conditions, infection requiring antibiotics or
 pregnancy

 -  Patients receiving daily anti-inflammatory medications including but not limited to
 prednisone, methotrexate, non-steroidal anti-inflammatory medications (ibuprofen,
 naproxen, indomethacin, celecoxib) and aspirin >325mg

 -  Glasgow Coma Score (GCS) 3 48 hours after admission

 -  Patients in whom withdrawal of life support is being considered by surrogate decision
 makers

 -  Injury to the lower extremities, hips or pelvis, weight >250 kg (weight limit of
 cycle), or body habitus precluding normal function of cycle