Treatment in Patients Hospitalized With Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Treatment in Patients Hospitalized With Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease has become a serious global health care and public
 health problems due to its high prevalence, high morbidity and heavy economic burden. Acute
 exacerbation of chronic obstructive pulmonary disease is one of the most important causes of
 death in patients with COPD. Systemic corticosteroids therapy is recommended in COPD
 exacerbations. In clinical practice for the treatment of acute exacerbation of COPD，
 antibiotic application is still controversial. Evidence from current guideline is based on
 strict criteria from randomized controlled trials, thus the given condition is simplified.
 Patients meet the criteria account for the minority in the real world. Therefore, it is still
 not clear whether most patients benefit from the recommended treatment. In our design,
 hospitalized patients with acute exacerbation of COPD will be enrolled, with their treatment,
 arterial hypoxemia, recovery time and length of hospitalization being observed. The main
 purpose is to evaluate the benefit effect of current recommended treatment of acute
 exacerbation of COPD in the real world.
Chronic obstructive pulmonary disease has become a serious global health care and public
 health problems due to its high prevalence, high morbidity and heavy economic burden. Acute
 exacerbation of COPD is one of the most important causes of death in patients with COPD. The
 global strategy for the diagnosis, management, and prevention of COPD recommends systemic
 corticosteroids therapy in COPD exacerbations as it can shorten recovery time, reduce
 treatment failure, improve lung function and arterial hypoxemia. In clinical practice for the
 treatment of acute exacerbation of COPD， antibiotic application is still controversial.
 Evidence from current guideline is based on strict criteria from randomized controlled
 trials, thus the given condition is simplified. Patients meet the criteria account for the
 minority in the real world. Therefore, it is still not clear whether most patients benefit
 from the recommended treatment. In our design, hospitalized patients with acute exacerbation
 of COPD will be enrolled, with their treatment, arterial hypoxemia, recovery time and length
 of hospitalization being observed. The main purpose is to evaluate the benefit effect of
 current recommended treatment of acute exacerbation of COPD in the real world.
Inclusion Criteria:

 -  Hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease

 -  Age≥ 40years old

 Exclusion Criteria:

 -  The first diagnosis which caused hospitalization is not acute exacerbation of chronic
 obstructive pulmonary disease

 -  Chest radiography shows congestive heart failure

 -  Chest CT shows lung cancer, active pulmonary tuberculosis, pulmonary thromboembolism
 or interstitial lung diseases

 -  Serious cardiac failure, renal insufficiency or hepatic dysfunction