Methods of Etiological Diagnosis of Cerebral Amyloid Angiopathy
Methods of Etiological Diagnosis of Cerebral Amyloid Angiopathy
The purpose of this study is to

 1. Early identify patients based on clinical manifestation, imaging, gene and histology,
 explore diagnostic tools

 2. get gene repertoire of Chinese

 3. Build a cerebral amyloid angiopathy (CAA) prospective cohorts, observing the disease
 history, and exploring prognostic factors of hemorrhage in CAA patients
We recruited consecutive patients with intracerebral hemorrhage(ICH). Clinical data and the
 results of laboratory tests and CT will be assessed and recorded. All the subjects will get
 gene tests including many genes related with Aβ and small vessel disease (Next-generation
 sequencing and target enrichment system) .

 The result of the MRI Scans including cerebral microbleeds(CMBs)、Cortical superficial
 siderosis（cSS）, white matter change(WMC) and enlarged perivascular spaces (EPVS) will be
 assessed using scales. Ocular fundus exams such as funduscopy and imaging will be used to
 assess multiple dot and blot hemorrhages and microaneurysms by ophthalmologist. Mini-mental
 state examination(MMSE) will be used to assess the cognitive function.

 Patients who need operation on the hematoma for the treatment will accept a brain tissue
 pathological exams According to this, a prospective cohort of CAA patients based on clinical
 manifestation, imaging, gene and histology will be built, and diagnostic tools such as gene
 and MRI results, etc will be explored. And we will get gene repertoire of Chinese patient
 with ICH.

 Then, the subjects will be followed up on 30-day, 3-month, 6-month, and 1-year.The patients'
 clinical outcome will be assessed , and the results of laboratory tests and therapy will be
 recorded. Prognostic factors of patients with CAA related ICH will be explored.
Inclusion Criteria:

 ①diagnosed wiht spontaneous cerebral hemorrhage after the head CT.

 ② the patients and their family members agreed to participate in this study.

 Exclusion Criteria:

 ①cerebral hemorrhage caused by traumatic, cerebral infarction, tumor and arteriovenous
 malformation.

 ②patients who can not provide reliable information or are considered unsuitable for the
 study.