Fluorescent Cholangiography and Bile Duct Stones
Fluorescent Cholangiography and Bile Duct Stones
Background. X-ray cholangiography has a high sensitivity and specificity of detecting bile
 duct stones and is the gold standard. There are no studies describing the sensitivity and
 specificity of IFC for bile duct stone detection.

 Research question. What is the sensitivity of IFC to visualize bile duct stones? Method.
 Prospective study with 40 patients undergoing planned laparoscopic cholecystectomy with
 preoperative magnetic resonance cholangiopancreatography (MRCP) (gold standard) and
 intraoperative IFC, X-ray cholangiography and choledochuscopy in that order.

 Primary outcome. Sensitivity of visualization of bile duct stone by fluorescent
 cholangiography and secondary outcome is visualization of anatomy.
Inclusion criteria

 -  Patients suspected of having bile duct stones by either blood samples, MRCP or medical
 history (see definitions)

 -  Patient age ≥ 18 years

 -  Preoperative MRCP

 -  Operation performed by a project surgeon

 Exclusion criteria

 -  Open cholecystectomy (including conversion from laparoscopic to open)

 -  Acute cholecytitis or cholangitis

 -  Pancreatitis

 -  Iodine or indocyanine green allergy

 -  Liver or renal insufficiency

 -  Thyrotoxicosis

 -  Cholecystectomy not the primary surgical procedure

 -  Pregnancy or lactation

 -  Legally incompetent for any reason

 -  Withdrawal of inclusion consent at any time