Effectiveness of Vitamin D in Primary Dysmenorrhoea
Effectiveness of Vitamin D in Primary Dysmenorrhoea
Vitamin D in the treatment of primary dysmenorrhoea. Design:Randomised controlled trial.
 Setting:In a university hospital. Population: 142 women aged 16-35 years. Methods: Patients
 were treated with 667 unit of vitamin D once a day, 200 unit of vitamin E once a day or 400
 mg ibuprofen twice a day,2 days before the date of menstruation and continued through the
 first 3 days, for 2 months. Main outcome measures: Pain score. Results: Mean VAS of vitamin D
 group was 4,91, was 6,54 in the vitamin E group and was 4,02 in the ibuprofen group
 Conclusion:Vitamin D and vitamin E are effective in relieving the pain,but the effect of
 vitamin D are more prominent
An excessive uterine production of prostaglandins is the pathogenic trigger of dysmenorrhoea.
 Nonsteroidal anti-inflammatory drugs (NSAIDs) are the currently accepted drugs for the
 management of this disorder. The capacity for synthesizing vitamin D and the presence of
 vitamin D receptor in human cycling endometrium have also been demonstrated. Because vitamin
 D reduces the synthesis of prostaglandins, a beneficial effect of vitamin D for the uterus is
 possible.Vitamin E inhibits the release of arachidonic acid and the conversion of arachidonic
 acid to prostaglandin via an action on the enzymes phospholipase A2 and cyclooxygenase.
Inclusion Criteria:

 1. Women had regular menstrual cycles lasted 21 to 35 days, with menstruation lasting 3
 to 7 days;

 2. Women had to be in good health and taking no medications including calcium, magnesium,
 vitamin D and oral contraceptives.

 3. Women had not a previous history of gynaecological disease, and a normal pelvic
 examination were eligible.

 Exclusion Criteria:

 1) Previous and current use of intrauterine contraceptive devices within the 6 months to
 enrollment was not permitted