Fluid Resuscitation Goal in Early Stage of Severe Acute Pancreatitis
Fluid Resuscitation Goal in Early Stage of Severe Acute Pancreatitis
To compare different goals of fluid resuscitation in early stage of acute pancreatitis
With regard to study of sepsis and several studies of SAP demonstrating the deleterious
 effects of fluid loss and haemoconcentration within the first 24h after admission（or onset of
 abdominal pain）, early goal-directed fluid resuscitation has the potential of improving
 outcome also in SAP. But the goal of fluid resuscitation remained controversial.Several
 criteria of fluid resuscitation had been described. Ours had been described in previous
 study, and had shown a ideal result with less incidence of abdominal compartment syndrome and
 higher survival rate. This study aims to determine a better goal of fluid resuscitation in
 severe acute pancreatitis.
Inclusion Criteria:

 -  1. Diagnosis of pancreatitis: Typical pain increase in serum lipase or amylase 2.
 Onset of abdominal pain within <=72h before admission 3. moderate severe or severe
 acute pancreatitis according to Atlanta criteria revisited in 2012 4. Evidence of >= 1
 predictor of fluid resuscitation: Haematocrit >44% (male) or >40% (female),
 respectively Lactate>4mmol/L; heart rate>120bpm; urine <0.5ml/kg/h for 6 hour; Mean
 arterial pressure>85 or <60 mmHg

 Exclusion Criteria:

 -  1. Pregnancy 2. New York Heart Association classification >II 3. With pacemaker
 implantation 4. chronic obstructive pulmonary disease 5. chronic kidney disease 6.
 Pre-existing disease with life expectancy < 3 months