Hypoalbuminemia in Mild Acute Stroke and Cognitive Impariment Post-stroke
Hypoalbuminemia in Mild Acute Stroke and Cognitive Impariment Post-stroke
This registration enrolled patients with acute ischemic stroke within 72 hours after stroke
 ictus. Patients was identified as first-ever stroke based on past medical histrory. Admission
 CT was conducted to exclude hemorrhagic stroke, but not those bleeding transformation after
 ischemia injury. Baseline characteristics, including demographics, vascular risk factors, lab
 tests and neuroimagings were collected. Patients were followed up for cognitive assessments.
This is a perspective stroke registry cohort study. Stroke patients were included if ：(1)
 acute first-ever ischemic stroke and admitted within 72 hours after onset; (2) clinical
 stroke diagnosis was confirmed with positive diffusion-weighted magnetic resonance imaging
 (DW-MRI), those with isolated posterior circulations infarcts were exclude ; (3) presented
 with mild stroke severity ( admission NIHSS score ≤5); (4) age between 40 and 80 years.

 Clinical data including demographic characteristics, risk factors, and baseline NIHSS score
 were assessed and collected using a standardized table by experienced neurologists. Lab tests
 were performed with fasting venous blood samples within 18 hours of admission.

 Patients were followed up for 6 months. The cognitive functions were assessed using the
 Chinese version of Montreal Cognitive Assessment (MoCA).

 Contributing factors to post-stroke cognitive impariment (PSCI) were determined by comparing
 clinical data between PSCI and non-PSCI groups. All potential confounders were introduced
 into the multivariate regression models.
Inclusion Criteria:

 1. acute first-ever ischemic stroke and admitted within 72 hours after onset;

 2. clinical stroke diagnosis was confirmed with positive diffusion-weighted magnetic
 resonance imaging (DW-MRI), those with isolated posterior circulations infarcts were
 exclude ;

 3. presented with mild stroke severity ( admission NIHSS score ≤5);

 4. age between 40 and 80 years.

 Exclusion Criteria:

 1. Patients with index cognitive impairment or under current anti-dementia or psychiatric
 medication;

 2. patients with large infarcts (≥1/3 middle cerebral artery territory);

 3. patients with severe language or physical disability that impede neuropsychological
 testing;

 4. patients with recurrent transient ischemic attack (TIA)/stroke during follow-up;

 5. coexisting serious conditions known to impair cognitive function