The Effect of Quercetin in Sarcoidosis
The Effect of Quercetin in Sarcoidosis
The exact cause of the chronic lung disease sarcoidosis is still unknown. Consequently, a
 complete efficacious treatment is still not available. Earlier studies indicate an important
 key role for oxidative stress, i.e. an imbalance between the production of and the protection
 against ROS, in the etiology of sarcoidosis. Antioxidants, needed for protection against ROS,
 are indeed lower in sarcoidosis. Therefore, antioxidant therapy to strengthen the reduced
 antioxidant defense might be efficacious in sarcoidosis treatment. Since ROS are also capable
 of initiating and mediating inflammation, antioxidant therapy might also mitigate the
 elevated inflammation that occurs in sarcoidosis. The flavonoid quercetin possesses both
 anti-oxidative and anti-inflammatory capacities and might therefore serve as a good candidate
 for antioxidant therapy in sarcoidosis.

 Therefore, the aim of the present study is to determine the effect of quercetin
 supplementation in sarcoidosis patients on markers of both oxidative stress and inflammation.
Inclusion Criteria:

 -  clinical diagnosis of sarcoidosis with emphasize on pulmonary sarcoidosis

 -  no smoking

 -  no treatment

 Exclusion Criteria:

 -  clinical diagnosis (and treatment) of other diseases

 -  symptoms of sarcoidosis in other organs besides the lung

 -  use of food supplements or vitamins