The Effect of GLP-1 on Postprandial Glucagon Secretion Independent of The Gastric Emptying Rate
The Effect of GLP-1 on Postprandial Glucagon Secretion Independent of The Gastric Emptying Rate
Aim: To investigate the glucagonostatic effect of glucagon-like peptide-1 (GLP-1) independent
 of the gastric emptying rate.
Aim: To investigate the glucagonostatic effects of glucagon-like peptide-1 (GLP-1) during
 prolonged and intermittent stimulation of the GLP-1 receptor independent of the gastric
 emptying rate. Glucagon concentrations will be measured following a liquid meal administered
 in duodenum at baseline and after exenatide, and liraglutide treatment.
Inclusion Criteria:

 -  Type 1 Diabetes

 -  >18 years

 -  No residual beta-cell function (stimulated C-peptide < 60 pmol)

 Exclusion Criteria:

 -  Pancreatitis

 -  gastroparesis

 -  history of alcohol and/or drug abuse

 -  pregnancy and lactation

 -  other medical or psychological condition that made the patient unsuitable for study
 participation according to the investigators´ assessment

 -  contraindications to gastroscopy

 -  cancer (unless in complete remission > five years)