Pregnancy in Osteogenesis Imperfecta (OI) Registry
Pregnancy in Osteogenesis Imperfecta (OI) Registry
The purpose of this study is to learn about pregnancy outcomes in osteogenesis imperfecta
 (OI). Patients enrolled in the Brittle Bone Disorders (BBD) Contact Registry (CR) will be
 invited via email to participate in this study.
Population: The RDCRN BBD Contact Registry helps researchers identify and recruit patients
 who are eligible for participation in future research studies. People eligible for enrollment
 in the RDCRN BBD Contact Registry include patients and parents of patients with Brittle Bone
 Disorders. All patients with BBD from the United States and around the world are encouraged
 to join.

 Survey Administration: The investigators will administer a review of pregnancy outcomes
 survey and delineate the outcomes in pregnancies complicated by varying forms of OI. Patients
 will be sent an email invitation describing the study. If the participant wants to
 participate and is eligible, she will follow the survey link in the email message, which
 directs her to an IRB-approved online consent form. A unique survey link will be generated
 for each participant and included in the survey invitation, which is a customized email
 message. This link will allow the investigators to determine who completed the survey. The
 investigators will send repeat email invitations every two months (total of 3 invitations) to
 those invitees who have not yet participated. The investigators will allow approximately 6
 months for enrollment and survey completion and expect that the study will close soon
 thereafter.

 Data: The survey data will be collected and stored at the Rare Diseases Clinical Research
 Network's Data Management and Coordinating Center (DMCC) at the University of South Florida.
 All data collected will be sent to the database of Genotypes and Phenotypes (dbGaP) to be
 stored indefinitely.
Inclusion Criteria:

 -  Female with OI who has delivered an infant of at least 24 weeks' gestation

 -  Participant in the BBD Contact Registry

 Exclusion Criteria:

 -  Inability to provide informed consent and complete survey

 -  Males

 -  Women with OI who have not delivered children and gestations associated with higher
 order multiples