Superior Silybin Bioavailability in Healthy Volunteers
Superior Silybin Bioavailability in Healthy Volunteers
Twenty-four healthy volunteers of both genders, aged 18 to 44 years old and body mass indexes
 between 18 to 27 kg/m2,were selected to participate in a two-way, balanced, prospective,
 blind, single-dose crossover study with a one-week wash-out period. It was assessed that
 volunteers were free from significant cardiac, hepatic, renal, pulmonary, neurological,
 gastrointestinal and hematological diseases. The volunteers clinical evaluation were
 determined by clinical examination, ECG, and the following laboratory tests: blood glucose,
 urea, creatinine, AST, ALT, GGT, alkaline phosphatase, total bilirubin and fractions, uric
 acid, total cholesterol, triglycerides, albumin and total protein, and routine urinalysis.
 All subjects were negative for HIV, HBV, and HCV.
In healthy volunteers single-dose crossover study with a one week, It was assessed that
 volunteers were free from significant cardiac, hepatic, renal, pulmonary, neurological,
 gastrointestinal and hematological diseases. The volunteers clinical evaluation were
 determined by clinical examination
Inclusion Criteria:

 -  volunteers were free from significant cardiac, hepatic, renal, pulmonary,
 neurological, gastrointestinal and hematological diseases.

 The volunteers clinical evaluation were determined by clinical examination, ECG, and the
 following laboratory tests: blood glucose, urea, creatinine, AST, ALT, GGT, alkaline
 phosphatase, total bilirubin and fractions, uric acid, total cholesterol, triglycerides,
 albumin and total protein, and routine urinalysis

 Exclusion Criteria:

 -  Subject with HIV, HBV, HCV

 -  Subject with comorbidities

 -  Subject less 18 years old Subject higher 50 years old