Subclinical Thyroid Dysfunction and Risk of Myocardial Infarction and Stroke
Subclinical Thyroid Dysfunction and Risk of Myocardial Infarction and Stroke
To examine the association of subclinical hypothyroidism and risk of myocardial infarction
 and stroke in a large prospective cohort of post-menopausal women.
BACKGROUND:

 Cardiovascular disease, including myocardial infarction (MI) and stroke, is the leading cause
 of death for women in the United States. Subclinical hypothyroidism (SCH), in which thyroid
 hormone levels are in the normal range but thyroid stimulating hormone (TSH) is elevated, has
 been linked to abnormal lipid profiles, atherosclerosis, and MI. The literature is scant
 however, and the evidence constrained by small studies, many of cross-sectional design. Both
 the US Preventive Services Task Force and the Institute of Medicine recently concluded that
 current data are insufficient to inform clinical decision-making about the need for screening
 or treatment for SCH.

 DESIGN NARRATIVE:

 This is a case-cohort study within the 93,676-member Observational Study of the Women's
 Health Initiative, including 800 women who have experienced an MI, 750 with
 thrombotic/embolic stroke, and a randomly selected subcohort of 3,200 women density-matched
 for age, race/ethnicity, and clinical center. Participants have extensive baseline
 demographic, health, behavioral, and physical exam data and stored serum available. The
 investigators will measure TSH and thyroid hormone levels in order to identify SCH at entry.
 Follow-up includes annual health status updates and a physical exam in the third year; >=5
 years have passed since enrollment for all women. Thus, using new laboratory studies and
 existing Women's Health Initiative (WHI) data, they will be able to answer these primary
 research questions: Among women without a history of thyroid disease, MI, or stroke: 1) Is
 subclinical hypothyroidism at baseline independently associated with risk of MI? 2) Is
 subclinical hypothyroidism at baseline independently associated with risk of ischemic stroke?
 3) What form of association best describes the relationship between TSH, as a continuous
 measure, and risk of MI and stroke? 4) What are the population correlates (i.e.,
 race/ethnicity, body mass index (BMI), hormone therapy, comorbidity) of SCH? This information
 - currently unavailable for middle-aged and older women - is germane to public health and
 health care policy to define the burden of illness associated with SCH, and to quantify the
 benefits and costs of eventual population screening and treatment
No eligibility criteria