Comparative Effects of Different Noninvasive Ventilation Mode on Neural Respiratory Drive in Recovering AECOPD Patients
Comparative Effects of Different Noninvasive Ventilation Mode on Neural Respiratory Drive in Recovering AECOPD Patients
Background: The efﬁciency of Neural respiratory drive (NRD)expressed by a ratio of
 ventilation to the diaphragm electromyogram (EMGdi) decreases in patients with COPD
 .Improving the neural respiratory drive efficiency of COPD will help to relieve the clinical
 symptom and make the patients feel comfort.Noninvasive positive pressure ventilation(NPPV)is
 a good treatment to AECOPD patients.It is unknown the effects of different mode of
 noninvasive positive pressure ventilation(NPPV) such as proportional assist ventilation (PAV)
 and pressure-support ventilation (PSV) on the efﬁciency of Neural drive of AECOPD and which
 mode benefit the patients more.

 Objective: To compare the short-term effects of mask pressure support ventilation (PSV) and
 proportional assist ventilation (PAV) on Neural respiratory drive in recovering patients of
 AECOPD
Methods: After the baseline data of spontaneous breathing was collected, 20 hypercapnic
 recovering AECOPD patients were placed on different mode of noninvasive positive pressure
 ventilation(NPPV, such as the PAV or PSV mode) randomly. For each mode, three levels (PA-,
 PA, PA+or PS-, PS, PS+), ) of support were applied.PS and PA are set for the patient's
 comfort . On the basis of these two levels, 25% increase and reduction assisted level of
 pressure were set both for PS and PA (PA-, PA+or PS-, PS+). At each level, the patients were
 ventilated at least 20 minutes until the breathing was stable. The respiratory frequency
 (RR), tidal volume (VT), transdiaphragmatic pressure (pdi) the pressure-time product (PTP)
 and root-mean-square(RMS) of EMGdi were calculated. Esophageal and gastric balloon-catheters
 were used to detect the intra-thoracic and abdominal pressure. Airway pressure was also
 measured simultaneously. EMGdi was recorded from a multipair esophageal electrode .During
 ventilation Airflow and ventilation were measured with pneumotachograph.
Inclusion Criteria:

 -  Clinical diagnosis of the COPD (Chronic Obstructive Pulmonary Disease) the COPD
 patients were all in stable condition during recovery from acute exacerbation.

 Exclusion Criteria:

 -  severe Cardiovascular disease

 -  Pneumonia

 -  neuromuscular and chest wall deformity

 -  Respiratory arrest

 -  Cardiovascular instability (hypotension, arrhythmias, myocardial infarction)

 -  Change in mental status; uncooperative patient

 -  High aspiration risk

 -  Viscous or copious secretions

 -  Recent facial or gastroesophageal surgery

 -  Craniofacial trauma

 -  Fixed nasopharyngeal abnormalities

 -  Burns

 -  Extreme obesity