His Bundle Pacing Versus Right Ventricular Pacing
His Bundle Pacing Versus Right Ventricular Pacing
This study will randomize cross-over periods of 6 months of right ventricular pacing and His
 bundle pacing in patients with baseline left ventricular ejection fraction (LVEF)>40%. The
 primary outcome measure is LVEF.
Monocentric, randomized, double-blind comparative crossover clinical study.

 Patients with a standard pacing indication with >20% ventricular pacing, with a baseline LVEF
 >40%, implanted with a functioning His bundle lead and a backup right ventricular lead, will
 be randomized to 6-months periods of right ventricular pacing and of His bundle pacing. The
 primary outcome is LVEF assessed by gated Equilibrium Radionuclide Angiography. Secondary
 outcomes are diastolic function, New York Heart Association (NYHA) functional class, quality
 of life, 6-minute walk test, heart failure hospitalisations and device electrical parameters.
Inclusion Criteria:

 -  Baseline LVEF>40%

 -  Standard pacing indication with >20% VP

 -  Functional His bundle lead with confirmed His capture

 -  Functional right ventricular lead with myocardial capture

 Exclusion Criteria:

 -  Unable to sign an informed consent form