Assessing the Effects of Omega-3 Supplementation on Serum HSP27, HSP70, YKL40, BMP-4 Levels in Male Patient With CAD
Assessing the Effects of Omega-3 Supplementation on Serum HSP27, HSP70, YKL40, BMP-4 Levels in Male Patient With CAD
The aim of this study is the comparison between the effects of supplementation with omega 3
 or placebo for 8 weeks in serum level of BMP-4, YKL40, HSP70, HSP27 in patients with
 cardiovascular disease.
The aim of this study is the comparison between the effects of supplementation with omega 3
 or placebo for 8 weeks in serum level of BMP-4, YKL40, HSP70, HSP27 in patients with
 cardiovascular disease. In this randomized, double-blind clinical trial, placebo-controlled,
 single-center, and phase two trials, 42men aged 45-65 years with Coronary Artery Disease are
 enrolled in the study from Tehran Heart Center. After signing informed consent all
 individuals complete a general information form , 24-hour food recall for 3 days will be
 taken from the participants at the beginning and the end of the study,. Selected samples are
 randomly classified into 2 blocks of groups receiving supplement and placebo. The supplement
 group, will receive 4 g/day omega 3 fatty acid for 8 weeks and the placebo group will also
 receive placebo (containing 4 g of edible paraffin) (similar in terms of color, shape and
 size). Patients are recommended to sustain their diets and medication dose (s) during the
 study and also advised to maintain a constant level of physical activity. Blood samples will
 be collected after 8-12 hours fasting and anthropometric variables, biochemical parameters
 and physical activity before and after the trial will be measured.
Inclusion Criteria:

 -  CVD patients 45- 65 years old, patients with ≥ 50% stenosis in at least one coronary
 angiogram demonstrated, body mass index in the range 18.5- 35, avoidance of dietary
 supplements, vitamins and herbal products at least 3 months before and throughout the
 intervention, willingness to participation,

 Exclusion Criteria:

 -  people who have used omega 3 supplements in last 3 months, having chronic renal
 disease , GI disease, hepatobiliary diseases, hematological disorders, hypo- or
 hyperthyroidism, Smokers