Quadrivas Therapy® to Reduce Lipedema Subcutaneous Adipose Tissue (QUADRIVAS)
Quadrivas Therapy® to Reduce Lipedema Subcutaneous Adipose Tissue (QUADRIVAS)
Quad Rivas Therapy has been developed by Alyna Eekma from the Netherlands for over thirteen
 years; anecdotally she has been able to significantly reduce lipedema SAT in women with Stage
 1 and 2 lipedema, and can reduce lipedema SAT by 80% in women with Stage 3 lipedema. The
 study will last for one month, for a total of 12 treatments per subject, seven subjects
 total, to see if there is a change in percent body fat percentage over the course of these
 treatments.
Lipedema

 According to an epidemiological study by Földi E and Földi M, lipedema affects 11% of the
 female population. Rarely, men with hypogonadism, growth hormone deficiency, or liver disease
 may develop lipedema. Drs. Allen and Hines from the Mayo clinic defined lipedema in 1940 and
 shortly thereafter provided the diagnostic criteria for lipedema:

 1. Almost exclusive occurrence in women developing by the third decade of life

 2. Bilateral and symmetrical nature with minimal involvement of the feet, resulting in an
 ''inverse shouldering'', ''bracelet'' or "cuff" effect at the ankle

 3. Minimal pitting edema (non-pitting edema is present)

 4. Pain, tenderness, and easy bruising

 5. Persistent enlargement despite elevation of the extremities or weight loss.

 6. Increased vascular fragility; easy bruising

 There are three stages of lipedema Stage 1: Normal skin surface with enlarged hypodermis
 Stage 2: Uneven skin with a peau d'orange or mattress-like texture with larger mounds of
 tissue the size of a walnut or apple including the formation of lipomas and angiolipomas, and
 larger indentations in the fat Stage 3: Much larger mounds or huge lobules of tissue occurs
 causing deformations especially around the knees

 Progression to lymphedema, called lipolymphedema (Stage 4) can develop during any Stage but
 most commonly occurs in people with Stage 3. Obesity can occur along with lipedema especially
 in Stage 3. Lifestyle improvements should always be considered for obesity associated with
 lipedema but lifestyle is not the cause of lipedema nor the cure.

 Women with lipedema have an obvious disparity between the larger quantity of gynoid
 distributed painful fat on the lower body (hips, buttocks, legs) compared to the trunk, head
 and face resulting in a low waist to hip ratio (WHR). The disparity results from the failure
 of lipedema SAT to reduce in response to extreme caloric restriction, including bariatric
 procedures, or intensive daily exercise. It is unclear why there is a drive to maintain
 lipedema SAT on the body. The SAT begins in typical gynoid locations (hips, buttocks, legs)
 and few women with lipedema have diabetes or metabolic syndrome suggesting that the lipedema
 SAT may be protective against cardiovascular disease similar to gynoid fat. However, in
 addition to being cosmetically devastating to many women, lipedema fat increases the risk of
 development of mobility issues, joint damage, chronic pain and lymphedema.

 Quad Rivas Therapy®

 The Quad Rivas Therapy® is a deep tissue "hands on" touch therapy of SAT which treats the
 body as an anatomical and physiological unit - all areas containing SAT are treated with a
 focus to improve functioning of blood vasculature, lymph vasculature, nerves, and the
 biomechanical system (muscle, tendons and fascia). The Quad Rivas Therapy® ensures these four
 systems are improved, but focuses on the vascular system. Tissues with decreased blood supply
 due to enlarged SAT mass, fibrosis or fascia disease need manipulation to be able to function
 properly again, allowing easy flow through the tissue. The Quad Rivas Therapy, therapist uses
 specialized grip techniques which enable the therapist to 'open' and 'unravel' tissues for an
 optimal blood supply. Another tissue technique, called the "hook technique" allows the
 therapist to ensure stimulation of blood flow. Blood vessels gain elasticity back, fibrosis
 in the veins resolves and the body is able to repair itself.

 The Quad Rivas Therapy® theory is that during puberty under the influence of hormones, the
 lipedema SAT outgrows the ability of muscles to use and break down fat resulting in excess
 SAT mass. This in combination with vascular, especially venous, insufficiency, which affects
 many women at a young age, creates a progressive disease that generates a blockage in
 metabolism associated due to setting up a hypoxic environment for the fat cells. Stimulating
 the affected area with Quad Rivas Therapy®, focusing on getting vessels back in top condition
 ensures the disappearance of lipedema SAT.

 Quad Rivas Therapy® results in the following:

 1. Recovery of the walls of the veins;

 2. Increased basal metabolic rate in muscles;

 3. Improved condition of the connective tissue.
Inclusion Criteria:

 1. Ambulatory females of any race able to understand the consent process.

 2. 19-70 years of age.

 3. Diagnosis of lipedema Stage 1 or Stage 2 although early Stage 3 will be considered.

 4. Weight stable for past three months per personal report of the subject.

 5. Must be able to attend all 12 treatments and pre and post procedures

 Exclusion Criteria:

 1. Use of medications that might cause weight gain and prevent fat loss (e.g., second
 generation anti-psychotics, corticosteroids).

 2. Current use of weight loss medications.

 3. Tobacco or marijuana use which may alter inflammation in the body.

 4. Pregnancy due to the risks associated with deep tissue treatment.

 5. Two or more alcoholic beverages per day, chronically.