MEK162 in Healthy Subjects With Normal Hepatic Function and Subjects With Impaired Hepatic Function
MEK162 in Healthy Subjects With Normal Hepatic Function and Subjects With Impaired Hepatic Function
This study is a phase I, multi-center, open-label, single oral dose, parallel group study to
 assess the PK and safety of MEK162 in subjects with impaired hepatic function and healthy
 subjects with normal hepatic function. Subjects will be assigned by hepatic function defined
 by elevation of serum total bilirubin and serum AST as determined at the screening and
 baseline visits. The study population will be healthy male and postmenopausal or sterile
 female subjects who meet all of the inclusion and none of the exclusion criteria. A minimum
 of 24 evaluable subjects (6 subjects per group) will be enrolled. The groups are: Group
 1-healthy volunteers, Group 2-Mild hepatic impairment, Group 3-Moderate hepatic impairment
 and Group 4-Severe hepatic impairment. Once approved for enrollment, participants will be
 confined to the facility for 5 days, given a single dose of MEK162 and monitored for safety
 assessments, labs and PK will be assessed.
Inclusion Criteria:

 -  Written informed consent prior to any screening procedures

 -  Male or female (postmenopausal or sterilized)

 -  Subject body weight at least 45 kg and a body mass index (BMI) in the range of 18 to
 35.0 kg/m2

 -  Subjects with normal hepatic function must have total bilirubin ≤ upper limit of
 normal (≤ ULN), alanine aminotransferase (ALT), aspartate aminotransferase (AST),
 gamma-glutamyl transferase (GGT) and alkaline phosphatase (AP) ≤ ULN, serum creatinine
 ≤ ULN, serum amylase and lipase ≤ ULN

 Additional inclusion criteria for subjects with abnormal liver function determined by
 elevation of serum total bilirubin are:

 -  Absolute neutrophil count (ANC) > 1000 cell/mm3

 -  Hb > 9 mg/dl,

 -  Platelet count > 30,000/mm3

 -  Serum creatinine ≤ 1.8 mg/dl

 -  Otherwise considered healthy and free of significant medical disorders unrelated to
 the subject's hepatic disorder

 Exclusion Criteria:

 -  Women of child-bearing potential

 -  Pregnant or nursing (lactating) women

 -  Subjects with impaired cardiovascular function or clinically significant
 cardiovascular diseases

 -  Uncontrolled arterial hypertension despite medical treatment

 -  History or current evidence of retinal vein occlusion (RVO) or current risk factors of
 RVO (e.g. uncontrolled glaucoma or ocular hypertension, history of hyperviscosity or
 hypercoagulability syndromes),

 -  History of Gilbert's syndrome

 -  Immuno-compromised subjects (including known history/seropositivity of HIV)

 -  Any surgical or medical condition (other than hepatic impairment) or receiving any
 pharmacological treatment which might significantly alter the absorption or metabolism
 of drugs or which may jeopardize the subject in case of participation in the study

 -  Antecedent of malignancy with the following exceptions: adequately treated basal cell
 or squamous cell carcinoma of the skin

 -  Subjects who have neuromuscular disorders that are associated with elevated CK (e.g.,
 inflammatory myopathies, muscular dystrophy, amyotrophic lateral sclerosis, spinal
 muscular atrophy)

 -  Subjects who have undergone major surgery ≤ 3 weeks prior to starting study drug or
 who have not recovered from side effects of such procedure

 -  History of clinically significant drug allergy

 -  Prior therapy with a MEK-inhibitor

 -  Use of an investigational drug within 30 days of screening

 -  Current smoker or has used tobacco products or products containing nicotine within 7
 days prior to dosing of study drug

 -  Consumption of alcohol within 3 days prior to dosing or during the study

 Additional exclusion criteria for subjects with normal hepatic function:

 - Clinical evidence of liver disease or liver injury as indicated by abnormal liver
 function tests such as ALT, AST, GGT, alkaline phosphatase, or serum bilirubin. ALT and AST
 beyond the normal range before inclusion Presence of impaired renal function as indicated
 by abnormal creatinine (creatinine clearance < 80 mL/min) values and/or serum creatinine
 ≥1.8 mg/dL- A positive Hepatitis B or Hepatitis C test result

 Additional exclusion criteria for subjects with elevation of serum bilirubin > UNL:

 -  Symptoms or history of encephalopathy (Grade II or worse) within 4 weeks of study
 entry

 -  Clinical evidence of severe ascites requiring intervention

 -  International normalized ratio (INR) >2.5

 -  Any evidence of progressive liver disease within the last 3 weeks prior to the
 screening visit) as indicated by worsening of clinical manifestations (i.e.: ascites,
 encephalopathy) and/or laboratories abnormalities (liver transaminases, alkaline
 phosphatase and GGT or a ≥ 50% worsening of serum bilirubin or prothrombin time)

 -  History of surgical portosystemic shunt with complications (i.e. hepatic
 encephalopathy, heart failure)

 -  Active bleeding during the last 28 days prior to dosing including variceal bleeding