Role of Leukotrienes and Adenosine in Hyperpnea-induced Bronchospasm
Role of Leukotrienes and Adenosine in Hyperpnea-induced Bronchospasm
This research is being conducted to help us better understand what causes exercise induced
 asthma. The investigators hypothesize that two types of chemicals, cysteinyl leukotrienes and
 adenosine, play an important role. The investigators will be measuring these chemicals in the
 exhaled breath of volunteers with exercise induced asthma as they undergo a test to mimic
 exercise induced asthma. The investigators will determine how the levels of these chemicals
 change in association with how lung function changes before, during and after an episode of
 exercise induced asthma.
Inclusion Criteria:

 -  Physician diagnosed asthma

 -  Age 12-75 yrs

 -  FEV1 > 70% predicted

 -  HIB response > 10 %

 -  No smoking last 6 mo and < 10 pack yrs

 -  No URI last 4 weeks

 -  No asthma exacerbation last 4 weks

 -  Able to withhold SABA > 8 hrs and LABA > 24 hrs

 Exclusion Criteria:

 -  Other lung disease

 -  Cardiac disease or other condition that would preclude safe participation, on
 theophylline or leukotriene modifiers