Optimal Multimodal Analgesia in Abdominal Hysterectomy
Optimal Multimodal Analgesia in Abdominal Hysterectomy
The purpose of this study is to test the current standard of care (SOC) treatment for
 abdominal hysterectomy with a group receiving SOC minus epidural analgesia plus additional
 perioperative analgesics in terms of postoperative abilities, postoperative nausea and
 vomiting (PONV), pain and discharge time from the PACU (post-anaesthesia care unit).
Aim of the study: to compare postoperative complaints (PONV, pain, etc) and PACU discharge
 time between two groups, for patients admitted for planned abdominal hysterectomy with or
 without BSO:

 -  A: standard of care (SOC) receiving paracetamol, celecoxib, epidural analgesia,
 dexamethasone, ondansetron and droperidol, and general anaesthesia with propofol,
 remifentanil and cisatracurium

 -  B: SOC with sham epidural analgesia, preoperative gabapentin, intraoperative lidocaine,
 s-ketamine and sufentanil
Inclusion Criteria:

 -  Planned abdominal hysterectomy with or without BSO

 -  Age above 18 years

 -  Written informed consent

 -  American Society of Anesthesiologists (ASA) class I-III

 Exclusion Criteria:

 -  Planned vaginal or laparoscopic hysterectomy

 -  Hysterectomy as part of other surgery

 -  Allergy to part of the treatment regimen

 -  Previous reactions to opioids (nausea, cognition)

 -  Previous inability to place correct epidural catheter

 -  Severe state anxiety according to the OCAP or STAI

 -  ASA class IV

 -  Dependency on alcohol, opioids or central stimulants

 -  Chronic pain condition

 -  Hemorrhagic diathesis

 -  Participation in another study