Efficacy of Long-acting Octreotide (Sandostatin LAR) in Reducing Portal Pressure in Patients With Cirrhosis
Efficacy of Long-acting Octreotide (Sandostatin LAR) in Reducing Portal Pressure in Patients With Cirrhosis
Octreotide is used to control variceal bleeding. However, octreotide has to be given through
 the vein and is effective for less than two hours.

 In this study the investigators determined whether a long-acting preparation of octreotide
 (Sandostatin LAR)given as an intra-muscular injection every month could decrease portal
 pressure, and thus be used to prevent variceal bleeding in patients with cirrhosis.
Inclusion Criteria:

 1. Cirrhosis documented by biopsy, or suggested by characteristic features on abdominal
 imaging (nodular appearance, irregular contour) along with impaired synthetic liver
 function and thrombocytopenia and Child Turcotte Pugh Class A or B.

 2. presence of small esophageal varices, defined as varices < 5 mm in diameter, without
 red signs documented on endoscopy within 3 months of enrollment

 3. age ≥ 18 years

 Exclusion Criteria:

 -  pregnant, lactating or of child-bearing potential and not practicing acceptable method
 of birth control

 -  allergic to sandostatin

 -  high risk varices on endoscopy carried out within 3 months of assessment (large
 varices or red signs)

 -  Child Turcotte Pugh Class C cirrhosis

 -  hepatocellular carcinoma

 -  evidence of ongoing alcohol or illicit drug abuse within 6 months of the study

 -  serum creatinine greater than 2 mg/dL

 -  platelet count below 50,000 per microliter

 -  prothrombin time 4 seconds or more greater than control

 -  human immunodeficiency virus (HIV) positive

 -  symptomatic gallstones

 -  previous history of upper gastrointestinal bleeding in the past 3 months, defined as
 hematemesis and/or melena

 -  previous history of variceal bleeding

 -  history of congestive heart failure , unstable angina, sustained ventricular
 tachycardia, or ventricular fibrillation

 -  use of any investigational drug within 1 month prior to screening and

 -  current use of beta blockers or long-acting nitrates, any other drug therapy known to
 have an influence on portal pressure (diuretics were allowed provided patients were on
 a stable dose for at least 30 days).