One Research on Improving Cognitive Impairment Caused by Hypertension
One Research on Improving Cognitive Impairment Caused by Hypertension
Using the therapy of early intervention with Qianyang Yuyin Granules to improve cognitive
 impairment caused by hypertension.
Using the therapy of early intervention with Qianyang Yuyin Granules to improve cognitive
 impairment caused by hypertension.

 The investigators designed a multi-center randomized controlled clinical trial to study the
 security and effectiveness of this therapy.
Inclusion Criteria:

 -  Aged 55 to 75 years old, male or female;

 -  Having a history of hypertension for more than 2 years but can maintain SBP ≤ 140 mmHg
 and BDP ≤ 90 mmHg with medication；

 -  21 ≤ MMSE < 26, or 14 ≤ MoCA < 26, CDR < 0.5. Bseides, the chief complaint must happen
 after having hypertension；

 -  Meet TCM Syndrome Differentiation Standard：according to the Guidelines for the
 Clinical Research of Chinese Medicine New Drugs ( published by China Medical Science
 Press ) ：Overabundant liver-fire type：dizziness and headache, both face and eyes are
 red, dry mouth and bitter taste in mouth, red tongue with yellowish coating, wire and
 frequent pulse. Yin deficiency and yang hyperactivity type: dizziness and headache,
 Tinnitus and forgetfulness, sphoria with feverish sensation in chest & palms & soles,
 palpitation and insomnia, red tongue & thin white or less coating, wiry weak and
 numbered pulse；

 -  CTMRI hint: leukoaraiosis and no sign of Cerebral infarction；

 -  Patients or the guardian hold the right opinions over the research and are willing to
 obey researcher's orders；

 -  Having a certain degree of education (being able to read simple newspapers in the
 past)；

 -  Patients agree to sign informed consent。

 Exclusion Criteria:

 -  Secondary hypertension；

 -  Taking certain kinds of antihypertensive drugs which may damage brain cognitive
 function；

 -  Diagnosed as depression or other mental disorders according to DSM-IV；

 -  Diagnosed as vascular dementia according to diagnostic criteria, CDR ≥ 0.5; alzheimer
 disease or dementia caused by some other reasons (including mixed dementia according
 to diagnostic criteria for VCI); cognitive impairment due to head injury。

 -  Suffering from certain kinds of diseases which may interfere the assessment of
 cognitive function, including those who are diagnosed as alcoholics and drugs or
 psychotropic medicine abusers during the last 5 years according to DSM-IV；

 -  Accompanied with severe neurological function disorder；

 -  Asthma, chronic severe primary cardiovascular disease, liver lesion, hematological
 lesions, lung diseases, diabetes or other severe diseases may influence the patients'
 survival such as cancer or AIDS；

 -  Other: Such as poor compliance, or can not attend the follow-up visit in time for some
 reasons；

 -  Taking the same kind of medicine during the last 30 days which may influence the
 trial；

 -  Is participating in another clinical study；

 -  Not up to TCM Syndrome Differentiation Standard。