Bacteriophage Therapy in Tonsillitis
Bacteriophage Therapy in Tonsillitis
The patients received bacteriophage therapy with a liquid piobacteriophage complex (liquid
 pyobacteriophage complex - PCL). PСL was administered via nebulizer inhalation to irrigate
 the tonsil mucosa. A total of 5 ml of PCL was inhaled for 10 minutes every 5 days. The drug
 causes the lysis of certain bacteria, including staphylococcus, enterococcus, streptococcus,
 enteropathogenic E. coli, Proteus vulgaris, Proteus mirabilis, Pseudomonas aeruginosa,
 Klebsiella pneumoniae and Klebsiella oxytoca. The choice of this drug was based on
 bacteriological studies.
Comprehensive outpatient treatment was based on standard clinical guidelines, and symptomatic
 treatment was performed. On the first day of diagnosis, patients were prescribed complex
 antibacterial therapy on the basis of possible causative agents. Subsequently, antibiotic
 therapy was adjusted based on the results of the bacteriological examinations. A total of 67
 patients received bacteriophage therapy using a liquid complex of pyobacteriophages
 (pyobacteriophage complex liquid - PСL). PСL was administered via nebulizer inhalation to
 irrigate the mucous membranes of the tonsils. In total, 5 ml of PCL was inhaled for up to 10
 minutes once every 5 days.

 The drug causes lysis of specific bacteria including Staphylococcus, Enterococcus,
 Streptococcus, enteropathogenic Escherichia coli, Proteus vulgaris, Proteus mirabilis,
 Pseudomonas aeruginosa, Klebsiella pneumoniae, and Klebsiella oxytoca. The drug is
 recommended for use for diseases of the ear, throat, nose, respiratory tract and lungs;
 inflammation of the sinuses and middle ear; tonsillitis; pharyngitis; laryngitis; tracheitis;
 bronchitis; pneumonia, pleurisy; and other inflammatory diseases. The choice of this drug was
 based on bacteriological studies.
Inclusion Criteria:

 -  children from 3 to 14 years old.

 -  children with sore throat.

 -  children diagnosed with acute tonsillitis.

 -  children diagnosed with acute respiratory infection (rhinitis, sinusitis,
 nasopharyngitis).

 -  children with the opportunity to visit the outpatient clinic.

 -  children with the ability to receive inhalation therapy.

 -  children from parents (or guardians) who have given written permission to conduct
 clinical and laboratory research.

 Exclusion Criteria:

 -  children under 3 years old and over 14 years old.

 -  children receiving hospital treatment.

 -  children with acute respiratory tract diseases (bronchitis, pneumonia, pleurisy).

 -  children with сhronic respiratory tract diseases (bronchitis, pneumonia).

 -  children who are allergic to antibiotics.

 -  children with cancer, immunological and hematological diseases.

 -  children with severe psychological illnesses (schizophrenia, mental retardation, etc.)

 -  children with cancer, immunological and hematological diseases.

 -  children with tuberculosis.