A Study to Evaluate Efficacy and Safety of Three W0027 Regimens in the Treatment of Moccasin Type Tinea Pedis (MTTP)
A Study to Evaluate Efficacy and Safety of Three W0027 Regimens in the Treatment of Moccasin Type Tinea Pedis (MTTP)
In this phase Ib, multi-centre, randomized, double-blind, placebo-controlled parallel group
 study, 120 subjects with moccasin type tinea pedis (MTTP) will be enrolled at approximately
 11 centres in the USA, Canada and Australia.

 The primary objective of the study is to assess the patient response to three W0027 regimens
 in subjects with MTTP. Secondary objectives include assessment of the safety, tolerability
 and skin and nail pharmacokinetics to the three Albaconazole regimens.
Inclusion Criteria:

 -  Subjects aged 18-65 years, who have been diagnosed with moccasin type tinea pedis (by
 positive dermatophyte culture, positive potassium hydroxide/calcofluor white
 preparation, and a Total Signs and Symptoms Score of at least 4).

 -  Females of childbearing potential must use contraceptive methods .

 Exclusion Criteria:

 -  Subjects who are receiving any CYP3A substrates with potential for QT prolongation;

 -  have used systemic antifungal drugs within 30 days of first dose; or topical
 antifungals within 2 weeks of first dose.

 -  Also excluded are those who have a clinically significant medical condition.