Diagnosing Heart Failure With Preserved Ejection Fraction in Patients With Unexplained Dyspnea (Diagnose-HFpEF)
Diagnosing Heart Failure With Preserved Ejection Fraction in Patients With Unexplained Dyspnea (Diagnose-HFpEF)
Invasive diagnosis of heart failure with preserved ejection fraction (HFpEF) in patients with
 unexplained dyspnea NYHA II-III compared to other diagnostic tools
Multiple diagnostic tests, including stress tests and the invasive conduction of left
 ventricular pressure-volume loops via conductance catheter (as gold standard) will be
 performed in patients with unexplained dyspnea NYHA II-III in order to identify patients with
 a heart failure with preserved ejection fraction (HFpEF). The results will be compared to
 previously reported diagnostic scores such as the H2FPEF and the HFA-PEFF score.
Inclusion Criteria:

 -  dyspnea NYHA II-III

 -  age 18-90 years

 -  left ventricular ejection fraction ≥ 50%

 -  ability to give informed consent

 Exclusion Criteria:

 -  unstable cardiac disease with acute decompensation

 -  documented former LVEF ≤ 40%

 -  heart valve disease with medium or high grade insufficiency or stenosis

 -  coronary heart disease with hemodynamically relevant coronary stenosis

 -  specific cardiomyopathia

 -  acute or chronic cardiac inflammation (myocarditis, pericarditis)

 -  former heart transplantation

 -  relevant pulmonary disease (e.g. COPD) assumably causing the dyspnea

 -  FEV1/VC < 70%

 -  hemoglobin < 5 mmol/l

 -  pregnant or nursing women

 -  contraindication for one of the diagnostic tests