Vaccine Responses to Influenza A H1N1/09 Immunization in High-risk Patients
Vaccine Responses to Influenza A H1N1/09 Immunization in High-risk Patients
The objective of this study is to assess vaccine responses to novel adjuvanted influenza
 A(H1N1) vaccines in patients at high risks of influenza A(H1N1) complications.
This prospective, open-label, parallel-cohorts study will include up to 1250 patients and 250
 controls to whom influenza A(H1N1) immunization was recommended.

 Six cohort have been established, enrolling patients with HIV infection, rheumatic diseases,
 organ transplant, cancer, pediatric patients and healthy controls.

 Subjects will be assessed for specific antibody responses (all), T cell responses (subset)
 and solicited vaccine adverse events. Vaccine safety evaluation will include the influence of
 immunization on underlying diseases (HIV infected patients, patients with auto-immune
 diseases) or graft function (transplant patients) - as appropriate.
Inclusion Criteria:

 -  medically recommended influenza A(H1N1) immunization

 -  signed informed consent

 Exclusion Criteria:

 -  failure or refusal to provide sufficient blood for antibody determination