AGN-241751 in the Treatment of Major Depressive Disorder
AGN-241751 in the Treatment of Major Depressive Disorder
The purpose of this study is to evaluate the efficacy at 1 day post initial oral dose of
 AGN-241751 compared with placebo in participants with Major Depressive Disorder (MDD).
Inclusion Criteria:

 -  Written informed consent from the participant has been obtained prior to any study
 -related procedures (as described in Appendix 3).

 -  Male or female participants must be 18 to 65 years of age, inclusive, at the time of
 signing the informed consent.

 -  Meet Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5)
 criteria for MDD (based on confirmation from the modified Structured Clinical
 Interview for DSM disorders [SCID]), with a current major depressive episode of at
 least 8 weeks and not exceeding 18 months in duration at Visit 1.

 -  Have a minimum score of 26 on the rater-administered Montgomery-Asberg depression
 rating scale (MADRS) and a minimum score of 24 on the computer-administered MADRS at
 both Visit 1 (Screening) and Visit 2 (Baseline).

 -  Have a difference of no greater than 7 points between the rater-administered MADRS and
 computer-administered MADRS at both Visit 1 (Screening) and Visit 2 (Baseline).

 -  Have a clinical global impression-severity (CGI-S) score ≥ 4 at both Visit 1
 (Screening) and Visit 2 (Baseline).

 -  Have a negative serum β-human chorionic gonadotropin (β-hCG) pregnancy test if a woman
 of childbearing potential (WOCBP).

 -  Female participants willing to minimize the risk of becoming pregnancy for the
 duration of the clinical study and follow-up period. A female participant is eligible
 to participate if she is not pregnant, not breastfeeding, and at least one of the
 following conditions applies:

 -  not a WOCBP OR

 -  A WOCBP who agrees to follow the contraceptive guidance in Appendix 5 of protocol
 during the treatment period and for at least 5 terminal half-lives after the last dose
 of study treatment.

 -  Male participants willing to minimize the risk of inducing pregnancy for the duration
 of the clinical study and follow-up period. A male participant must agree to use
 contraception as detailed in Appendix 5 of this protocol during the treatment period
 and for at least 5 terminal half-lives after the last dose of study treatment and
 refrain from donating sperm during this period.

 -  Able, as assessed by the investigator, and willing to follow study instructions and
 likely to complete all required study visits.

 -  Normal physical-examination findings, clinical-laboratory test results, and
 electrocardiogram (ECG) results from Visit 1 (Screening) or abnormal results that are
 determined to be not clinically significant by the investigator.

 -  Body mass index (BMI) within the range 18 and 40 kg/m^2 (inclusive).

 -  Eligibility confirmed through a formal adjudication process (see Section 9 Diagnostic
 Assessments).

 Exclusion Criteria:

 Psychiatric and Treatment-Related Criteria

 -  DSM-5-based diagnosis of any disorder other than MDD that was the primary focus of
 treatment within 6 months before Visit 1. Comorbid generalized anxiety disorder,
 social anxiety disorder, or specific phobias are acceptable provided they play a
 secondary role in the balance of symptoms and are not the primary driver of treatment
 decisions.

 -  Lifetime history of meeting DSM-5 criteria for:

 -  Schizophrenia spectrum or other psychotic disorder

 -  Bipolar or related disorder

 -  Major neurocognitive disorder

 -  Neurodevelopmental disorder of greater than mild severity or of a severity that
 impacts the participant's ability to consent, follow study directions, or otherwise
 safely participate in the study

 -  Dissociative disorder

 -  Posttraumatic stress disorder

 -  MDD with psychotic features

 -  History of meeting DSM-5 criteria for alcohol or substance use disorder (other than
 nicotine or caffeine) within the 6 months before Visit 1.

 -  DSM-5-based diagnosis of any personality disorder of sufficient severity to interfere
 with participation in this study in the opinion of the investigator.

 -  History (based on participant report and/or medical records, and investigator
 judgment) of:

 -  Inadequate response to electroconvulsive therapy (ECT), a monoamine oxidase inhibitor,
 ketamine, or adjunctive treatment with an antipsychotic

 -  Treatment with clozapine or any depot antipsychotic

 -  ECT, vagus nerve stimulation, transcranial magnetic stimulation, or any experimental
 central nervous system treatment during the current episode or in the 6 months before
 Visit 1 (whichever is longer)

 -  Tardive dyskinesia, serotonin syndrome, or neuroleptic malignant syndrome

 -  Having received:

 -  Anticonvulsant/mood stabilizer, within 1 year prior to Visit 1

 -  Antipsychotic in the current episode, with the exception of quetiapine given for
 insomnia ≤ 50 mg/day provided it can be safely discontinued prior to Visit 2

 -  Combination therapy of 2 or more antidepressant therapies (ADTs) in the current
 episode if given for depression at adequate dose and duration

 -  ADT augmentation agent in the current episode

 -  Lifetime history of nonresponse to ≥ 2 antidepressants after adequate trials (adequate
 treatment is defined as at least 6 weeks at an adequate dose(s) based on approved
 package insert recommendations) or a non-response to an antidepressant after adequate
 treatment for the current major depressive episode.

 -  Positive result at Visit 1 from the urine drug screen (UDS) test for any prohibited
 medication. Exception: participants with a positive UDS at Visit 1 for opiates,
 cannabinoids, or episodic use of benzodiazepines may be allowed in the study provided:

 -  The drug was used for a legitimate medical purpose;

 -  The drug can be discontinued prior to participation in the study (except for episodic
 use of benzodiazepines which may be continued); and

 -  A repeat UDS is negative for these substances prior to enrollment (except for episodic
 use of benzodiazepines which may be continued)

 -  Suicide risk, as determined by meeting any of the following criteria:

 -  A suicide attempt within the past year

 -  Significant risk, as judged by the investigator, based on the psychiatric interview or
 information collected in the C-SSRS at Visit 1 (Screening) or Visit 2 (Baseline)

 -  MADRS Item 10 score ≥ 5 at Visit 1 (Screening) or Visit 2 (Baseline) on the MADRS

 -  At imminent risk of injuring self or others or causing significant damage to property,
 as judged by the investigator.

 -  Requiring concomitant treatment with any of the prohibited medications, supplements,
 or herbal products listed in Appendix 6 of protocol, including any psychotropic drug
 or any drug with psychotropic activity, except as described in Section 7.7.2. of
 protocol.

 -  Prior participation in any investigational study of AGN-241751.

 -  Initiation or termination of psychotherapy for depression within the 3 months
 preceding Visit 1, or plans to initiate, terminate, or change such therapy during the
 course of the study. (Support meetings or counselling [eg, marital counselling] are
 allowed provided they are no more frequent than weekly and do not have treatment of
 depression as their objective).

 -  Ongoing treatment with phototherapy, or termination of phototherapy within 1 month of
 Visit 1.

 -  Known allergy or sensitivity to the study medication or its components.

 Other Medical Criteria

 -  BMI < 18 kg/m^2 or > 40 kg/m^2 at screening.

 -  Females who are pregnant, breastfeeding, or planning to become pregnant or breastfeed
 during the study.

 -  WOCBP and male partners of WOCBP, not using a reliable means of contraception
 (Appendix 5 of protocol).

 -  Participant has a condition or is in a situation which, in the investigator's opinion,
 may put the participant at significant risk, may confound the study results, or may
 interfere significantly with the participant's participation in the study.

 -  Any cardiovascular disease that is clinically significant, unstable, or decompensated.

 -  Heart rate (supine) of ≤ 45 beats per minute (bpm) or ≥ 120 bpm, or any heart rate
 that is clinically symptomatic at Visit 1 or Visit 2 based upon vital signs.

 -  Any systolic and/or diastolic blood pressure (BP) that is symptomatic or clinically
 significant in the opinion of the investigator.

 -  History of congenital QTc prolongation or QTc prolongation (screening ECG with QTcF ≥
 450 msec for men and QTcF ≥ 470 msec for women).

 -  Hypothyroidism or hyperthyroidism, unless stabilized on appropriate pharmacotherapy
 with no change in dosage for at least 1 month before Visit 1.

 -  History of seizure disorder, stroke, significant head injury, tumor of the central
 nervous system, or any other condition that predisposes to seizure.

 -  Known human immunodeficiency virus (HIV) infection.

 -  Positive hepatitis C antibody on screening, with the exception of participants for
 whom the reflex hepatitis C virus ribonucleic acid (HCV RNA) test is negative.

 -  Positive test for hepatitis B surface antigen and/or hepatitis B core antibody
 immunoglobulin M.

 -  Screening liver enzyme test (aspartate aminotransferase [AST] and/or alanine
 aminotransferase [ALT]) results > 2 times the upper limit of normal (ULN).

 Other Criteria

 -  Current enrollment in an investigational drug or device study or participation in such
 a study within 6 months of entry into this study.

 -  Employee, or immediate relative of an employee, of the sponsor, any of its affiliates
 or partners, or the study center.

 -  Inability to speak, read, and understand the English language sufficiently to
 understand the nature of the study, to provide written informed consent, or to allow
 the completion of all study assessments.