Clinical and Radiographic Evaluation of Guided Tissue Regeneration With Radiation-sterilized Allogenic Bone Grafts or Xenogenic Grafts for the Treatment of Intrabony Defects in Aggressive Periodontitis
Clinical and Radiographic Evaluation of Guided Tissue Regeneration With Radiation-sterilized Allogenic Bone Grafts or Xenogenic Grafts for the Treatment of Intrabony Defects in Aggressive Periodontitis
The treatment of intrabony defects in patients with aggressive periodontitis remains a
 challenging procedure and novel therapeutic strategies are sought. The purpose of this study
 is to compare the clinical and radiographic outcomes of using guided tissue regeneration
 (GTR) with radiation-sterilized allogenic bone grafts (material prepared in the Central
 Tissue Bank in Warsaw, Poland) versus guided tissue regeneration with xenogenic grafts
 (Bio-Oss®, Geistlich Biomaterials, Princeton, New Jersey, United States) in the treatment of
 localized intrabony defects in patients with aggressive periodontitis.
Inclusion Criteria:

 -  Diagnosis of aggressive periodontitis in line with American Academy of Periodontology
 classification (Lang et al. 1999)

 -  Familial aggregation (history of periodontitis in parents or siblings)

 -  Presence of at least two teeth with probing pocket depth (PPD) ≥ 6mm and clinical
 attachment level (CAL) ≥ 5 mm associated with an intrabony defect of at least 3 mm as
 detected in diagnostic periapical radiographs

 -  No furcation involvement of the teeth presenting the intraosseous defects

 -  The width of keratinized tissue on the facial aspect of the selected teeth ≥ 2 mm

 Exclusion Criteria:

 -  Full-mouth plaque index ≥ 20% (Ainamo & Bay 1975)

 -  Full-mouth sulcus bleeding index ≥ 15% (Mühlemann & Son 1971)

 -  Smoking more than 10 cigarettes/day

 -  Systemic diseases with compromised healing potential of infectious diseases

 -  Drugs affecting periodontal health / healing

 -  Pregnant and lactating females

 -  Previous periodontal surgery in the area