Sex-Mismatched Allogeneic Bone Marrow Transplantation for Men With Metastatic Castration-Resistant Prostate Cancer
Sex-Mismatched Allogeneic Bone Marrow Transplantation for Men With Metastatic Castration-Resistant Prostate Cancer
Men with progressive metastatic Castration-Resistant Prostate Cancer post first-line
 treatment with either androgen deprivation therapy alone or androgen deprivation therapy plus
 docetaxel who have an identified related female donor (mother sister, daughter, second degree
 relative such as granddaughter or niece) will undergo bone marrow transplantation followed by
 post-transplant Cytoxan (PT/Cy) and testosterone.
Men will undergo pre-transplant screening evaluation and be enrolled in the study. Subjects
 will be treated with a standard non-myeloablative conditioning regimen consisting of
 Fludarabine 30 mg/m2 IV Days -6 to -2; Cy 14.5 mg/kg IV Days -6 and -5; Total body
 irradiation (TBI) 200 cGy Day -1. On Day 0, patients will be infused with non-T-cell depleted
 bone marrow from a related female donor. Patients will receive GVHD prophylaxis consisting
 of: Cy 50mg/kg IV on Days +3 and +4; tacrolimus (IV or PO) beginning on Day +5 [dose adjusted
 to maintain trough level of 5-15 ng/mL] through day+180; Mycophenolate mofetil (MMF) 15 mg/kg
 PO TID, with a maximum dose of 1g TID beginning on Day +5 through Day +35. Patients will
 receive filgrastim (G-CSF) 5 mcg/kg/day beginning on Day +5 and continued until ANC ≥
 1500/mm3. Lastly, to produce maintenance tumor antigen stimulation, patients will be
 maintained on continuous LHRH agonist/antagonist therapy (if not previously surgically
 castrated) to suppress endogenous testosterone production throughout the treatment period;
 testosterone cypionate 400 mg IM will be administered on Day +60, +90, and +120 (every 30
 days x 3 doses). Patients who achieve biochemical CR will stop LHRH agonist/antagonist
 treatment at day 180. Patients will be followed for 3 years post-BMT.
Inclusion Criteria:

 -  Performance status ≤1

 -  Age ≥18 years and ≤ 75 years old

 -  Histologically-confirmed adenocarcinoma of the prostate

 -  Treated with continuous androgen ablative therapy (either surgical castration or LHRH
 agonist/antagonist) with documented castrate level of serum testosterone (<50 ng/dl)

 -  Metastatic disease radiographically documented by CT or bone scan

 -  Patient must be HLA typed at high resolution using DNA based typing at the following
 loci: HLA-A, -B, -C, and DRB1

 -  Patient must have available one or more potential first (biologic mother, sister,
 half-sister, or daughter) or second-degree related female donor. Mothers and daughters
 have a 100% chance of being haploidentical matches, sisters a 75% chance of being
 matched or haploidentical, and second degree relatives have a 50% chance of being
 haploidentical matches. The donor and recipient must be HLA identical for at least one
 antigen at HLA-A, -B, -C and HLA-DRB1.

 -  Screening PSA must be ≥ 1.0 ng/mL.

 -  Prior therapy with one second line hormonal therapy is allowed (i.e. bicalutamide,
 nilutamide, flutamide, ketoconazole, abiraterone, enzalutamide, ARN-509).

 -  Prior docetaxel (≤ 6 cycles) as first line therapy

 -  Cardiac ejection fraction at rest must be ≥ 40%

 -  Acceptable liver function: Bilirubin < 2.5 mg/dL (unless due to Gilbert's disease, AST
 (SGOT) and ALT (SGPT) < 5 times upper limit of normal.

 -  Acceptable renal function: Serum creatinine within normal range.

 -  Pulmonary function: DLCO (corrected for hemoglobin), FEV1 and FVC >50% predicted.

 -  At least 4 wks since prior radiation or surgery with full recovery (no persistent
 toxicity ≥ Grade 1)

 -  Ability to understand and willingness to sign a written informed consent document.

 Exclusion Criteria:

 -  Prior treatment with Sipuleucel-T, radium-223, strontium-89, or samarium-153

 -  Prior chemotherapy (docetaxel, cabazitaxel) for castrate resistant prostate cancer

 -  Evidence of serious and/or unstable pre-existing medical, psychiatric or other
 condition (including laboratory abnormalities) that could interfere with patient
 safety or provision of informed consent to participate in this study

 -  Active uncontrolled infection, including known history of HIV/AIDS or hepatitis B or
 C.

 -  Any psychological, familial, sociological, or geographical condition that could
 potentially interfere with compliance with the study protocol and follow-up schedule.