Irinotecan Plus Cyclosporine and Phenobarbital in Treating Patients With Solid Tumors or Lymphoma
Irinotecan Plus Cyclosporine and Phenobarbital in Treating Patients With Solid Tumors or Lymphoma
Phase I trial to study the effectiveness of irinotecan plus cyclosporine and phenobarbital in
 treating patients who have solid tumors or lymphoma that is refractory to standard therapy.
 Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop
 growing or die. Cyclosporine and phenobarbital may enhance the effectiveness of irinotecan.
OBJECTIVES:

 I. Determine the maximum tolerated dose of irinotecan (CPT-11) when infused weekly with
 cyclosporine (CYSP) in patients with solid tumors or lymphoma refractory to standard therapy.

 II. Determine whether CYSP modulates the pharmacokinetics and pharmacodynamics of CPT-11 and
 its active metabolite, SN-38.

 III. Determine whether phenobarbital modulates the pharmacokinetics and pharmacodynamics of
 CPT-11 and SN-38.

 OUTLINE: This is a dose escalation study of irinotecan. Patients are stratified according to
 gender.

 Part I: Patients receive cyclosporine IV over 6 hours and irinotecan IV over 90 minutes
 weekly for 4 weeks. Courses repeat every 6 weeks in the absence of unacceptable toxicity or
 disease progression. Cohorts of 3-12 patients receive escalating doses of irinotecan until
 the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose at which at
 least one third of patients experience dose limiting toxicity (DLT).

 Part IIA: If the DLT is diarrhea in part I, then part IIA is opened. Patients receive oral
 phenobarbital, cyclosporine as in part I, and irinotecan at the MTD from part I. Dose
 escalation occurs as in part I to determine a new MTD. If the DLT continues to be diarrhea,
 the study is closed. Part IIB: If the DLT is neutropenia in part I, then part IIB is opened.
 Patients receive cyclosporine as in part I and escalating doses of irinotecan to determine a
 new MTD.

 Part III: If the DLT is neutropenia in part IIA or any DLT in part IIB, patients receive
 phenobarbital, cyclosporine, and irinotecan at the MTD determined as in part IIA or part IIB.
 Dose escalation continues until a new MTD is determined.
DISEASE CHARACTERISTICS:

 -  Malignant solid tumor or lymphoma refractory to standard therapy or for which no
 therapy of proven benefit exists

 -  No leukemia

 -  Measurable or evaluable disease

 PATIENT CHARACTERISTICS:

 -  Age: 18 and over

 -  Performance status: Karnofsky 70-100%

 -  Life expectancy: At least 3 months

 -  WBC at least 3,500/mm3

 -  Absolute neutrophil count at least 1,500/mm3

 -  Platelet count at least 100,000/mm3

 -  Hemoglobin at least 9 g/dL

 -  Bilirubin no greater than 1.5 mg/dL

 -  AST/ALT less than twice normal (unless due to disease)

 -  PT and PTT normal

 -  Creatinine no greater than 1.5 mg/dL

 -  Creatinine clearance at least 60 mL/min

 -  No history of congestive heart failure requiring medical therapy

 -  No clinically significant or life threatening cardiac arrhythmia

 -  No history of significant pulmonary disease or lymphangitic lung disease

 -  No hypersensitivity to cyclosporine or cremophore

 -  No history of manifest or latent porphyria or hypersensitivity to barbiturates (for
 parts of study using phenobarbital)

 -  No history of inflammatory bowel disease requiring therapy

 -  No chronic diarrhea syndrome or paralytic ileus

 -  No medical or psychiatric condition that precludes informed consent

 -  Not pregnant

 -  Effective contraception required of fertile women

 PRIOR CONCURRENT THERAPY:

 -  At least 4 weeks since prior biologic therapy

 -  At least 2 weeks since prior colony stimulating factors

 -  At least 4 weeks since prior chemotherapy (at least 6 weeks since nitrosoureas or
 mitomycin)

 -  No prior bleomycin or irinotecan

 -  At least 4 weeks since prior radiotherapy to greater than 25% of bone marrow

 -  Minimum time interval between prior therapy and eligibility shortened by 2 weeks when
 phenobarbital is administered

 -  Concurrent use of medications that affect the central nervous or cardiovascular
 systems (e.g., anticonvulsants, calcium channel blockers, oral contraceptives) must be
 approved by the Principal Investigator