Prevalence of Vitamin D Deficiency in Type 1 Diabetes Mellitus and Effect of Supplementation on Insulin Requirements
Prevalence of Vitamin D Deficiency in Type 1 Diabetes Mellitus and Effect of Supplementation on Insulin Requirements
Our objective is to demonstrate that providing supplemental vitamin D to children with new
 onset DM will significantly decrease the levels of HbA1c and insulin requirement by the
 following methods.

 1. Identify how often vitamin D levels are low in patients with new onset Type 1 diabetes
 mellitus (DM).

 2. Record the hemoglobin A1c (HbA1c) level (which reflects the average blood sugar level
 over the past few months) and document insulin requirements before and after vitamin
 supplementation is given.

 Hypothesis: Maintaining vitamin D levels >30 ng/ml will decrease HbA1c and insulin
 requirements.
New onset type 1 DM patients who present at William Beaumont Hospital, Royal Oak or to the
 Pediatric Endocrine Clinic will be approached about the study at their presentation and time
 will be given for the patient and family to discuss and ask questions regarding the study.
 Patients will then be enrolled following informed consent. Glucose levels and insulin
 requirements will be monitored continuously from the faxed weekly logbooks from the point of
 diagnosis for 3 months (as standard practice for all newly diagnosed diabetic patients in our
 clinic). At the baseline visit a Vitamin D level will be drawn and frozen for 3 months prior
 to processing. .After 3 months vitamin D, calcium, alkaline phosphatase, phosphorus and other
 standard of care lab draws will be done. Approximately an additional 3 tsp of blood will be
 taken. All female subjects of child bearing potential will have a pregnancy test done. EMLA
 cream to anesthetize the area will be used prior to blood draw. A vitamin D level of <30
 ng/ml is considered insufficient and the patient will then be given vitamin D supplement. The
 vitamin D level, calcium, alkaline phosphatase and phosphorus will be rechecked at 6 months
 (additional 3 tsp of blood) . Glucose levels and insulin requirements will be monitored
 continuously from the faxed weekly logbooks again for another 3 months.
Inclusion Criteria:

 -  Newly diagnosed type I DM.

 -  Age <18 years

 Exclusion Criteria:

 -  Pregnancy