Prospective Study Using Hybrid PET/MRI to Evaluate Men With Suspected Recurrence Following Treatment for Prostate Cancer
Prospective Study Using Hybrid PET/MRI to Evaluate Men With Suspected Recurrence Following Treatment for Prostate Cancer
Evaluate the impact of hybrid 18F-Fluoro-choline (18F-FCH) PET/MRI imaging on the clinical
 management of men with suspected recurrent prostate cancer post prostatectomy or
 radiotherapy.

 We hypothesize that hybrid imaging incorporating 18F-FCH PET/MRI imaging will be feasible and
 will lead to changes in management decisions among men being re-staged for suspected prostate
 cancer recurrence post-surgery or radiation who are potentially eligible for local salvage
 therapy.
The study will be a non-randomized, prospective study of men with suspected local recurrence
 of prostate cancer post-prostatectomy or radiation with negative bone and CT scans. Hybrid
 PET/MRI using 18F-FCH will be obtained and a consensus staging report generated for the
 attending clinician. Clinical management questionnaires completed by the study investigator
 will be obtained pre and post imaging in order to gauge the impact of the hybrid imaging on
 clinical decision making.
Inclusion Criteria:

 -  Prostate cancer with rising prostate specific antigen (PSA) post prostatectomy or
 radiotherapy

 -  Suspected recurrence based on PSA rise measured on 3 occasions at least 3 months apart
 and an absolute PSA > 0.2 ng/mL

 -  Bone scan and CT scan of the abdomen and pelvis negative for metastatic disease

 Exclusion Criteria:

 -  Evidence of metastatic disease

 -  Contradiction to 18F-FCH PET scan

 -  Contraindication to MRI