Research Project: Pilot Study on Oral Urea Use in Patients at High Risk of Kidney Stone Recurrence
Research Project: Pilot Study on Oral Urea Use in Patients at High Risk of Kidney Stone Recurrence
In clinical practice, many patients are not able to modify their habits to achieve a high
 level of diuresis and fluid intake and therefore are at an elevated risk for stone
 recurrence.

 The investigators think that Ure-Na (osmotic agent) taking could help to increase urine
 volume and decrease urine concentration, which would be of benefit in the prevention of
 kidney stones.
Inclusion Criteria:

 -  18 to 60 years of age

 -  High risk for recurrence (1 or more of) Bilateral or complex stones, Recurrent stones,
 Family history (1st degree relative), Non-calcium stones, Solitary kidney or
 anatomical abnormality, Nephrocalcinosis, Systemic disease with risk of stones
 (tubular acidosis, cystinuria, etc.)

 -  Diuresis < 1.8 L/24 hours despite recommendations from physicians and/or nutritionist
 at the kidney stone clinic (as documented in the previous 6 months)

 Exclusion Criteria:

 -  Patient does not meet 1 of the 3 inclusion criteria

 -  Pregnancy or breastfeeding

 -  Lack of understanding about the protocol and effects of Ure-Na

 -  Expected inability to adequately increase fluid intake on Ure-Na