Leptin: a Therapeutic Option for Treating Catabolic States and Malnutrition in Critically Ill Patients
Leptin: a Therapeutic Option for Treating Catabolic States and Malnutrition in Critically Ill Patients
Leptin is a hormone that plays a central role in food intake and energy balance. It is
 secreted by fat cells, released into the circulation and transported into the central nervous
 system (brain), where it regulates energy balance and food intake. The overall effects of
 leptin appear to reduce food intake when the body is calorically satisfied, and to alter
 metabolic rate A decrease in the amount of body fat, which occurs after fasting, reduces the
 level of leptin, thereby stimulating food intake. Systemic Inflammation is a condition in
 which body tissues respond to stress. It may be associated with severe infection or other
 stimuli such as trauma, and may lead to organ failure and death. It has been shown, that
 Leptin may be a "survival protein", where higher levels are associated with lower mortality.
 The investigators set out to quantify the levels of Leptin in critically ill patients in
 association with other markers of inflammation and mortality.
Patients admitted to the Medical Intensive Care Unit who comply with criteria for SIRS
 (Systemic inflammatory response syndrome) will be enrolled into the study.

 SIRS can be diagnosed when two or more of the following are present:

 -  Heart rate > 90 beats per minute

 -  Body temperature < 36 or > 38°C

 -  Hyperventilation (high respiratory rate) > 20 breaths per minute or, on blood gas, a
 PaCO2 < 32 mm Hg or mechanically ventilated

 -  White blood cell count < 4000 cells/mm3 or > 12000 cells/mm3 (< 4 x 109 or > 12 x 109
 cells/L), or the presence of greater than 10% immature neutrophils.

 Clinical parameters will be collected including: demographics, diagnosis, past medical
 history, past and present medications, fluids and nutrition administered, oxygenation and
 ventilation parameters, hemodynamic status and renal function and/or replacement therapy.
 Severity of illness using APACHE II score, major events during unit stay such as procedures,
 length of inotropic support, complications. Length of unit and hospital stay, length of
 ventilation, unit and hospital outcome.

 Baseline leptin levels (within 8 hours of admission) will be obtained. Subsequent levels of
 leptin will be measured every 2 days or until discharge from the unit or death.

 Serial blood count, chemistry, total protein, albumin, renal and liver function, glucose and
 insulin levels, lactate, total cholesterol, TSH, T3, IL-6, TNF-a, adiponectin, CRP, ESR,
 urine output, creatinine clearance and Nitrogen balance will be obtained.
Inclusion Criteria:All patients with Systemic Inflammatory Response Syndrome (SIRS).

 SIRS can be diagnosed when two or more of the following are present:

 -  Heart rate > 90 beats per minute

 -  Body temperature < 36 or > 38°C

 -  Hyperventilation (high respiratory rate) > 20 breaths per minute or, on blood gas, a
 PaCO2 < 32 mm Hg or mechanically ventilated

 -  White blood cell count < 4000 cells/mm3 or > 12000 cells/mm3 (< 4 x 109 or > 12 x 109
 cells/L), or the presence of greater than 10% immature neutrophils.

 Exclusion Criteria:

 -  Patients under 18, pregnant patients, patients who refuse to participate