6 Minute Walk Test in Cystic Fibrosis
6 Minute Walk Test in Cystic Fibrosis
The purpose of this study is to determine whether the 6-minute walk test (6MWT) could be a
 prognostic factor for cystic fibrosis patients.
The 6-minute walk test is a simple exercise test, reproducing a daily physical activity. The
 utility of this test is described in several chronic lung diseases (chronic obstructive
 pulmonary disease, idiopathic pulmonary arterial hypertension). The distance performed during
 the 6MWT and / or desaturation during the 6MWT is a prognostic factor that contributes to the
 assessment of patients for lung transplantation indication.

 The 6MWT is practiced routinely in cystic fibrosis centers but its usefulness in this disease
 has not been shown. Also the results of this test are not part of the decision-making
 criteria for lung transplantation.

 A single-center study performed in adults CRCM at Cochin Hospital suggests the prognostic
 value of the 6MWT in patients with adult's cystic fibrosis.

 The principal objective of this study is to assess the prognostic of 6MWT as part of the
 cystic fibrosis. The primary endpoint will be to assess the survival without lung transplant
 during the follow up period of 3 years. In this context, this prognostic tool could be used
 to help to determine the best time to consider a lung transplant in cystic fibrosis patient.
Inclusion Criteria:

 -  Patient with Cystic Fibrosis (bronchiectasis with presence of two mutations in the
 CFTR gene and / or positive sweat test.

 -  Patients aged 18 year or older.

 -  Pre-bronchodilator FEV1 FEV1 ≤ 60% from theoretical value: this FEV1 limits is
 proposed following the results from our published study (Martin et al. 2013) showing
 that desaturation during 6MWT and a distance ≤ 475m performed, are almost exclusively
 found in patients with FEV1 ≤ 60% .

 -  Stable health status ( >15 days after the start of treatment of a respiratory
 exacerbation

 -  No indications against the walking test:

 Left uncontrolled heart failure Severe aortic stenosis acute endocarditis syncope
 Symptomatic severe arrhythmia stable angina Myocardial infarction <5 days Acute respiratory
 distress Resting SpO2≤85% pulmonary edema Uncontrolled asthma Arterial or venous thrombosis
 of the lower limbs, Severe acute condition that may interfere with the exercise performance
 (infections, renal failure, hyperthyroidism, unable to cooperate, severe pulmonary arterial
 hypertension, severe systemic blood pressure (Systolic blood pressure >200 mm Hg and / or
 diastolic blood pressure >120 mm Hg))

 Exclusion Criteria:

 -  History of lung transplant

 -  Oxygen Dependence (inability to achieve a 6-minute walk test in ambient air)

 -  Any indication against walk test

 -  Pregnant women, persons deprived of liberty, person under guardianship, person in
 emergency situation

 -  Person not affiliated to social security system

 -  Refusal to participate in the study