Characterizing Inflammatory Bowel Disease With 68Ga-FAPI PET/CT
Characterizing Inflammatory Bowel Disease With 68Ga-FAPI PET/CT
68Ga-FAPI has been developed as a tumor-targeting agent as fibroblast activation protein is
 overexpressed in cancer-associated fibroblasts and some inflammation,such as inflammatory
 bowel disease. And it might be more sensitive than FDG in detecting a certain type of
 inflammations according to our preliminary research. Thus this prospective study is going to
 investigate whether 68Ga-FAPI PET/CT may be superior for diagnosis, therapy response
 assessment and follow-up of inflammatory bowel disease than 18F-FDG PET/CT.
Inflammatory bowel disease (IBD) is comprised of two major disorders: ulcerative colitis (UC)
 and Crohn's disease(CD).CD is an autoimmune condition resulting in chronic gut inflammation
 that can be complicated by intestinal fibrosis and stricture formation. Ulcerative colitis is
 characterized by recurring episodes of inflammation limited to the mucosal layer of the
 colon. It commonly involves the rectum and may extend in a proximal and continuous fashion to
 involve other parts of the colon. Studies identified FAP to be overexpressed in uninflamed
 strictures compared with nonstrictured colonic regions in biopsies taken from Crohn's disease
 patients. But preliminary studies showed FAP was not overexpressed in colonic biopsies taken
 from healthy individuals or individuals with ulcerative colitis.68Ga-FAPI has been developed
 as a tumor-targeting agent as fibroblast activation protein is overexpressed in
 cancer-associated fibroblasts and inflammation. Recently we have published an article of the
 application of 68Ga-FAPI in IgG4-related disease which showed it was more sensitive than FDG
 in detecting a certain type of inflammations. Thus this prospective study is going to
 investigate whether 68Ga-FAPI PET/CT may be superior for diagnosis, therapy response
 assessment and follow-up of IBD than 18F-FDG PET/CT.
Inclusion Criteria:

 -  suspected or confirmed untreated inflammatory bowel disease patients;

 -  18F-FDG PET/CT within two weeks;

 -  signed written consent.

 Exclusion Criteria:

 -  pregnancy;

 -  breastfeeding;

 -  known allergy against FAPI

 -  any medical condition that in the opinion of the investigator may significantly
 interfere with study compliance.