Detection of Biomarkers in Abnormal Cervical Cells in Women With Abnormal Pap Test Results
Detection of Biomarkers in Abnormal Cervical Cells in Women With Abnormal Pap Test Results
RATIONALE: Examining biomarkers in abnormal cervical cells may improve the ability to detect
 these cells and plan effective treatment.

 PURPOSE: Diagnostic trial to detect specific biomarkers in abnormal cervical cells in women
 who have abnormal Pap test results.
OBJECTIVES: I. Compare the detection of transferrin receptor, epidermal growth factor
 receptor, and the MaTu-MN protein in exfoliated cervical epithelial cells from women with
 abnormal Pap test using fluorescent labeled antibody probe vs histology.

 OUTLINE: Patients undergo a Pap test and a colposcopy. Cervical epithelial cells are
 collected from the most abnormal appearing lesion. Cells are examined for molecular markers
 using a fluorescent antibody test. The presence or absence of these markers is compared to
 results of the Pap test and the histology of the cells.

 PROJECTED ACCRUAL: A total of 100 patients will be accrued for this study within 6 months.
DISEASE CHARACTERISTICS: Diagnosis of abnormal Pap test, as indicated by one of the
 following: Atypical squamous cells of undetermined significance (ASCUS) Low grade squamous
 intraepithelial lesion (LGSIL) High grade squamous intraepithelial lesion (HGSIL) Visible
 lesion on cervix by colposcopy

 PATIENT CHARACTERISTICS: Age: Any age Performance status: ECOG 0-4 Life expectancy: Not
 specified Hematopoietic: Not specified Hepatic: Not specified Renal: Not specified Other:
 Pregnant or nursing women allowed

 PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: Not specified
 Endocrine therapy: Not specified Radiotherapy: No prior pelvic irradiation Surgery: No
 prior total hysterectomy