The Research of Metabolomics on COPD
The Research of Metabolomics on COPD
Targeted metabolomics research was conducted on patients with chronic obstructive pulmonary
 disease (COPD). The correlation analyst between inflammation-related metabolites and lung
 function was analyzed by explored the metabolic pathways of inflammation-related omega-6 and
 omega-3 and combining them with lung function.
Based on the global initiative for chronic obstructive pulmonary disease, the 80 confirmed
 stable COPD patients with mild-to-moderate were involved, 80 COPD patients with severe and
 very severe, and age, sex, all matching 40 cases without lung disease. The participants
 information was collected. Whole blood and pulmonary function were examined at three time
 points: admission, six months and one year, at the same time, targeted metabolomic analysis
 method are applied to detect serum metabolites, According to the access to assess the
 different severity of COPD in the stable period and the level of metabolites in different
 admission periods. After that, correlation analysis was conducted with pulmonary function
 indicators and other clinical indicators to observe the research value of
 inflammation-related metabolites in the development of COPD.
Inclusion Criteria:

 -  COPD diagnosis

 -  The age ranges from 40 to 80

 -  No other pulmonary diseases

 -  No immune-related diseases

 Exclusion Criteria:

 -  Not consistent with COPD diagnosis

 -  Age is out of range

 -  Interstitial lung disease, asthma and other lung diseases

 -  Immune system diseases

 -  Lost to follow-up