Low-dose Chemotherapy Combine With Tyrosine Kinase Inhibitor to Treat ph+ Acute Lymphoblastic Leukemia Patients
Low-dose Chemotherapy Combine With Tyrosine Kinase Inhibitor to Treat ph+ Acute Lymphoblastic Leukemia Patients
The aim of our study is to improve the major molecular remission(MMR) rate and reduce the
 cost to treat ph(+) Acute Lymphoblastic Leukemia (ALL) by adjusting chemotherapy regimens and
 the dosage of Tyrosine Kinase Inhibitor (TKI). lower the classification of chemotherapy
 drugs, lower the side effect brought by which this would be a grateful news for the patients
 once this regimens gain a successful result, which is also the final aim of our efforts.
The investigators new therapy regimens: The investigators use dexamethasone 10mg/d(d3-d7) as
 pre-processing therapy, dasatinib 100mg (d1-d84) plus prednisone 60mg/m2 (d1-24), reduce to
 d32, as inductive treatment after inductive treatment, if the patient get major molecular
 remission, patient will get to consolidation therapy, that is methotrexate (MTX) 3g/m2 d1, if
 not, this patient would be excluded from our trail. after consolidation therapy, if the
 patient have matched bone marrow donor, the investigators will suggest the patient receipting
 allogens-stem cell transplantation, otherwise, autogens stem cell transplantation can also be
 considered once the patient have no applicable bone marrow donor. on the other side, if the
 patient still not get MMR after this two cycle, maybe the patient can try Car-T, or other
 chemotherapy regimens.
Inclusion Criteria:

 1. Get signed the informed consent of patients and family members

 2. Age ≥ 18 one full year of life

 3. Confirm the ph + ALL at molecular biology level

 4. Normal heart and lungs function

 5. Normal liver and kidney function

 Exclusion Criteria:

 1. Leukemia in the nervous system

 2. Recurrent patients

 3. Allergies associated with any drug in our research

 4. At the same time with other organs' malignant tumours

 5. participating in other clinical researches at the same time