Analisis of Facors Involved in Antidepressant Treatment Response of Major Depressive Disorder
Analisis of Facors Involved in Antidepressant Treatment Response of Major Depressive Disorder
The purpose of this study is to predict and visualize sertraline treatment response in major
 depressive disorder with clinical symptoms, demographic and stress state, personality, eight
 genetic polymorphisms at baseline.
While only about 50% of patients respond to first treatment in major depressive disorder,
 30-40% did not remit after continuous 1 year treatment. However, patients must remain on
 their prescribed medications for at least 4 weeks without knowing whether the particular
 antidepressant will be effective. Studies have suggested a number of predictors of treatment
 response, but varying degrees of success and nearly all with poor prognostic sensitivity and
 specificity. The investigators investigated clinical symptoms, demographic and stress state,
 personality and genetic polymorphisms in patients of major depressive disorder treated with
 sertraline and performed multivariate analysis to extract the predicting factors. Moreover,
 the investigators tried to visualize weight of variables and pathway one another.
Inclusion Criteria:

 -  clinical diagnosis of Major Depressive Disorder

 -  Must be able to swallow tablets

 Exclusion Criteria:

 -  pregnant

 -  breastfeeding