Prospective Longitudinal Cohort Study of Vasculitis Patients
Prospective Longitudinal Cohort Study of Vasculitis Patients
VASCO is a prospective observational cohort study which aim to describe the presentation,
 comorbidities, management, outcomes and damage of vasculitis patients, from the analysis of
 the clinical, biological and immunological data.
Vasculitis is a group of disorders characterized by the inflammation of blood vessels,
 leading to an alteration of the vascular wall. The classification of vasculitides has evolved
 considerably over the last few decades.

 In 1990, the American College of Rheumatology established a classification of the main
 systemic vasculitides based on clinical, biological and histological criteria. In 1994, the
 Chapel Hill nomenclature has been established as the reference classification system of
 vasculitides and vasculitides were classified according to the size of the affected vessels.
 The Chapel Hill nomenclature was revised in 2012, thus enabling to integrate new vasculitides
 and diagnostic tools.

 It is proposed here to conduct a non-interventional cohort study of the different forms of
 vasculitis, as defined in the Chapel Hill nomenclature. By collecting data from a large
 number of patients followed prospectively, our objective is to describe the clinical patterns
 of these diseases, the presentation, management, comorbidities and outcomes, and to evaluate
 their possible association with some immunological, genetic and molecular parameters.
Inclusion Criteria:

 -  Adult patients (age over 18 years),

 -  Patients with vasculitis, as defined in the Chapel Hill International Nomenclature as
 revised in 2012,

 -  Patients included at an active phase of the disease, either the initial flare or a
 relapse,

 -  Patients who have been informed and have signed the consent

 -  Pregnant and breastfeeding women may be included in the study,

 -  Affiliated to a social security system (beneficiary or entitled person).

 Exclusion Criteria:

 -  Refusal of consent or inability to obtain consent,

 -  A patient who is insane or not entitled, for psychiatric reasons or intellectual
 impairment, to receive information about the protocol and to give informed consent,

 -  Patient under guardianship / curators

 -  Patient on state medical assistance (AME)

 -  Hemoglobin less than 7 g/dl at the time of sampling,

 -  Hemoglobin level less than 9 g/dl at the time of sampling if the patient has
 respiratory or cardiovascular disease,

 -  Patient weighs less than 18 kg.

 -  Parallel participation in an interventional protocol is permitted.