The Underlying Mechanism of Spinal Manipulative Therapy and the Effect of Pain on Physical Outcome Measures
The Underlying Mechanism of Spinal Manipulative Therapy and the Effect of Pain on Physical Outcome Measures
The purpose of this study is to compare changes in spinal stiffness and back muscle activity
 between spinal manipulative therapy (SMT) responders, non-responders and asymptomatic
 participants. Additionally, the investigators wanted to compare the amount of lumbar
 degeneration between SMT responders, non-responders and asymptomatic participants. This study
 also determines if the presence of pain modifies post-SMT spinal stiffness and back muscle
 activity.
SMT is a common manual therapy for treating patients with mechanical low back pain (LBP). SMT
 is defined as a high velocity, low amplitude thrust technique. Specifically, the clinician
 stands beside a supine patient. The patient is passively side-bent towards the side to be
 manipulated. The clinician passively rotates the patient and then delivers a high velocity,
 low amplitude thrust to the anterior superior iliac spine in a posteroinferior direction. SMT
 is indicated for patients with LBP judged to have spinal hypomobility or malalignment.
 Recently, our collaborators have discovered that LBP subjects who benefit from SMT can be
 identified prior to treatment by a five-item clinical prediction rule. Compared to
 non-responders, those who respond to SMT have: 1) more than 30% decrease in the modified
 Oswestry Disability Index score, 2) a significant and immediate decrease in spinal stiffness,
 and 3) a concurrent change in lumbar multifidus muscle activity. Taken together, the physical
 changes experienced by SMT responders alone provide an unique opportunity to better
 understand the mechanisms underlying SMT.

 Since spinal stiffness is an important physical indicator of SMT response, it is important to
 understand the causal relation between pain, paraspinal/trunk muscle activity and spinal
 stiffness. Although research has shown positive correlation between pain and muscle activity,
 and between paraspinal muscle activity and spinal stiffness, the causal relation between
 pain, paraspinal/trunk muscle activity and spinal stiffness remains unknown. Given this
 background, an induction of temporary benign experimental pain to asymptomatic individuals
 can help clarify such causal relation and improve our understanding of physical responses in
 responders following pain resolution by SMT.
Inclusion Criteria:

 -  Self ambulatory participants with or without acute/chronic LBP. LBP is defined as pain
 or discomfort between costal margin and above the gluteal folds, with or without leg
 pain.

 -  All the included LBP participants must have modified Oswestry Disability Index score >
 12%

 -  Have the ability to lie prone for at least 20 minutes.

 -  Asymptomatic participants should be free from LBP at the time of visit.

 Exclusion Criteria:

 -  With medical 'red flag' conditions such as cancer, cauda equine syndrome, spinal
 infection, fracture or systemic disease

 -  History of arm surgery, shoulder or arm pain that may hinder the arm lifting in prone

 -  History of orthopedic or neurological surgery to the spine, pelvis or hips

 -  Inflammatory or active infective processes involving spine or shoulder

 -  Spondylolisthesis, ankylosing spondylitis, scoliosis of greater than 20 degrees
 (Cobb's angle)

 -  Pregnancy

 -  Osteoporosis

 -  Neurologic deficit or signs of nerve root compression

 -  Congenital spinal disorder (such as spina bifida),

 -  Participation in competitive sports more than 3 times per week

 -  History of spinal manipulation or lumbar multifidus stabilization exercise training
 within the past 4 weeks

 -  Additional exclusion criteria for asymptomatic participants include: back pain in the
 preceding year, or exceeding 1 week; missed at least 1 work day because of back pain;
 and consultation for a back problem.