Effects of Antidepressant on Postsynaptic Signal Transduction in Serotonergic System of Depressed Patients
Effects of Antidepressant on Postsynaptic Signal Transduction in Serotonergic System of Depressed Patients
The purpose of this study is to determine whether alteration of signal transduction
 components after antidepressant targeting, predict antidepressant responsiveness in advance
 before the appearance of the drug effects until 4~6 weeks after drug administration, or
 represent the clinical status of depressed patients.
The purpose of this study is to determine whether antidepressants effect on signal
 transduction in peripheral lymphocyte and to determine whether the signaling differences
 between drug responders and nonresponders predict the antidepressant response or represent
 the clinical status of depressed patients.
Inclusion Criteria:

 1. met the Diagnostic and Statistical Manual of the American Psychiatric Association
 (DSM-IV) criteria for MDD from the Department of Psychiatry, Sungkyunkwan University,
 Seoul, South Korea.

 2. were 18 years of age or older, the existence of a unipolar major depressive episode as
 verified by DSM-III/IV criteria, at least 2 years after first episode onset, and
 agreement to informed consents

 Exclusion Criteria:

 -  pregnancy

 -  significant medical conditions

 -  abnormal laboratory baseline values

 -  unstable psychiatric features (e.g, suicidal attempt)

 -  history of alcohol or drug dependence, seizure, neurological illness, or concomitant
 Axis I psychiatric disorder