Exogenous Ketones and Glucose Tolerance
Exogenous Ketones and Glucose Tolerance
The ketone body beta-hydroxybutyrate is produced during prolonged fasting or when endogenous
 carbohydrate stores are depleted and can be used as an alternative fuel source. Exogenous
 beta-hydroxybutyrate, in the form of a ketone monoester, is proposed to have glucose-lowering
 potential but this has not been adequately studied. The purpose of this study is to determine
 whether supplementing with an acute dose of ketone monoester can improve the glycemic
 response to an oral glucose tolerance test in individuals with impaired fasting glucose.
Inclusion Criteria:

 -  Not taking any medications affecting glucose metabolism.

 -  Elevated fasting glucose level (5.6-6.9 mmol/L) OR body mass index >28 kg/m2 OR
 elevated waist circumference (>102 cm for males, >88 cm for females)

 Exclusion Criteria:

 -  Diagnosed with diabetes.

 -  Diagnosed with heart disease.

 -  Competitive endurance athlete (self-identified as engaged in specific endurance
 training in triathlon, cycling, or distance running and competing in races or
 competition)

 -  Recent (last 3 months) or current consumption of a low-carbohydrate ketogenic diet

 -  Current consumption of ketone supplements

 -  Pregnant or planning to become pregnant during the study (if female)