Quantitative Imaging and Proton Spectroscopy in Multiple Sclerosis
Quantitative Imaging and Proton Spectroscopy in Multiple Sclerosis
The primary purpose of this study is to detect changes in the brain that may be associated
 with multiple sclerosis. Results will be compared to age matched controls. Investigators will
 assess lesions by measuring T2 and T1 enhanced lesion volumes and magnetization transfer
 ratio histogram parameters (MTRHP) in patients with relapsing-remitting and
 secondary-progressive disease. This data will be correlated to total brain parenchymal volume
 as well as identifying the effect of MS lesions on the gray and white matter, volumetric
 disability, including Kurtzke Expanded Disability Status Scale (EDSS) and a specific battery
 of neuropsychological tests. Quantitative analysis of whole brain N-acetylaspartate (WBNAA),
 a reproducible measure of viable neuron number, using 1H MRS and compare the results to
 age-matched controls over duration of 5 years.
Inclusion Criteria:

 1. Patients with known MS diagnosis

 2. Age 7-110 years

 3. Males or females

 Exclusion Criteria:

 1. Medically unstable

 2. Artificial implants in the body

 3. Pregnant

 Normal Controls