Ketoanalogues and Stage 4 CKD
Ketoanalogues and Stage 4 CKD
Investigators intend to analyze diets restricted in protein and supplemented with
 ketoanalogues of essential amino acids, to slow the progress of renal damage and improve
 nutritional status in diabetic patients over 60 years with stage 4 chronic kidney disease.

 Evey 2 months, evaluations will be performed of renal function (creatinine clearance, serum
 cysteine, proteinuria) and nutritional status (subjective global evaluation,dominant had
 pressure strength, body composition by bioelectric impedance, serum transferrin, serum
 prealbumin and serum aminogram) for a follow-up period of 2 years.
Inclusion Criteria:

 -  Patients with diabetic nephropathy in stage 4 chronic kidney disease

 -  Patients in pre-dialysis

 -  Patients with signed informed consent forms.

 Exclusion Criteria:

 -  Patients who have received Ketosteril previously

 -  Patients participating in other intervention studies

 -  Pregnant women

 -  Patients with background of renal transplant

 -  Patients with cancer, HIV, seropositive for hepatitis B or C or receiving
 immunosuppressors, hypercalcemia

 -  Intolerance of Ketosteril ingredients

 -  Hereditary disorders in amino acid metabolism