The Effect of Agomelatine or Fluoxentine on Heart Rate Variability in Patients With Major Depressive Disorder
The Effect of Agomelatine or Fluoxentine on Heart Rate Variability in Patients With Major Depressive Disorder
Phase advance of HRV will be anticipated in agomelatine group. It is anticipated that both
 agomelatine and floxentine will increase HRV at the end of the treatment.
Phase advance of HRV will be anticipated in agomelatine group. It is anticipated that both
 agomelatine and floxentine will have equal efficacy in improvement of depressive symptoms and
 increasement of HRV at the end of the treatment.
Inclusion Criteria:

 -  Asian patients

 -  Male or female

 -  18 to 65 years outpatients

 -  DSM-IV-TR criteria for Major Depressive Disorder

 Exclusion Criteria:

 -  Patients with cardiac conditions and other physical conditions contraindicated for
 drug study

 -  Shift worker

 -  Patients known to be non-responders to fluoxetine treatment

 -  Pregnancy, or breastfeeding