The Effect of Topical Doxycycline Gel on HbA1c in Patients With Type 2 Diabetes Mellitus(DM) ®
The Effect of Topical Doxycycline Gel on HbA1c in Patients With Type 2 Diabetes Mellitus(DM) ®
Aim:

 The purpose of this study is to investigate the effect of nonsurgical periodontal therapy
 plus subgingivally doxycycline gel 3% on glycemic control in type 2 diabetes mellitus (type 2
 DM) patients who have periodontitis.

 Materials and methods:

 A total of 24 type 2 DM patients with periodontitis will be selected for the study, and
 randomly divided into two equal groups,who are at least 35 years of age and 16 teeth and type
 II diabetes are (at least the last 3 months of diagnosis of diabetes and its FBS More than
 110 have), and also with periodontal disease are chronic moderate (at least in three areas
 Attachment level to a depth of 3-4 mm maxillary or mandibular been confirmed by clinical
 examination and radiographic signs are being); Takes place. The initial HbA1c Patients should
 be between 7-9 percent over the past three months has changed his medication also found the
 necessary explanations on how to do that consent, Plaque index (PI) by Loe & Silness,
 bleeding on probing (BOP) based on Carter and Barnes (if any bleeding number 1 and its
 absence is 0), probing depth (PD) and clinical attachment levels (CAL) were recorded. "Group
 1": (12 patients) was treated with oral hygiene instruction, scaling and root planing, and
 doxycycline gel for 15 days; and "Group 2": (12 patients) has the same treatment but with
 placebo gel, After 12 weeks their periodontal condition and Fasting blood sugar (FBS),
 glycated hemoglobin (HbA1c) level, will be reevaluated.
Doxycycline downregulates the activity of matrix metalloproteinases (MMPs), key destructive
 enzymes in periodontal disease
Inclusion Criteria:

 -  Patients with diabetes mellitus type II (at least 3 months before diagnosis, and A
 fasting blood sugar level of more than 125 mg/dl) and has periodontal disease is a
 chronic moderate (has a clinical attachment level of 3-4 mm) peritonitis

 -  Minimum of 16 natural teeth, and no periodontal treatment in the prior 6 months, - Had
 a glycated α hemoglobin (HbA1c) value between 7- 9 percent at screening

 -  Had reported no changes in diabetes medications within the last 3 months were in the
 care of a physician for their diabetes.

 Exclusion Criteria:

 -  Pregnancy or lactation

 -  History of allergy to drugs used in the study

 -  Smoking

 -  Diabetes-related emergency within 30 days ago

 -  Use of nonsteroidal anti-inflammatory drugs

 -  Or taking low dose daily aspirin (75-325 mg)\

 -  Use of immunosuppressive medications; antibiotic use

 -  Dialysis

 -  Risk of bleeding complications

 -  The type of disease periodontal (Aggressive)

 -  A history of periodontal treatment in the previous 6 months

 -  Orthodontic treatment

 -  Using the removal prostheses

 -  Extensive dental caries

 -  Dental abscesses or infections.