Pituitary Histopathology and Hyperprolactinaemia and Risk of Glucose Metabolic Disturbances in Acromegaly.
Pituitary Histopathology and Hyperprolactinaemia and Risk of Glucose Metabolic Disturbances in Acromegaly.
Acromegaly is frequently associated with impaired glucose tolerance and diabetes. We
 hypothesise that pituitary histopathology and plasma hyperprolactinaemia could have
 prognostic value in predicting the risk of glucose metabolic disturbances in acromegalic
 patients. The aim of this study is to examine glucose metabolic outcome in acromegalic
 patients with and without histologically verified prolactin and growth hormone (GH)
 co-secreting adenomas. The study population include 79 patients who have all undergone
 surgical treatment for acromegaly.
Acromegaly is frequently associated with impaired glucose tolerance and diabetes. We
 hypothesise that pituitary histopathology and plasma hyperprolactinaemia could have
 prognostic value in predicting the risk of glucose metabolic disturbances in acromegalic
 patients. The aim of this study is to examine glucose metabolic outcome in acromegalic
 patients with and without histologically verified prolactin and growth hormone (GH)
 co-secreting adenomas. 79 patients who have all undergone surgical treatment for acromegaly
 are included. Clinical and biochemical baseline data are collected from medical records.
 Patients are divided into two groups based on histopathological evaluation of pituitary
 adenomas;

 1. pure GH secreting adenomas or

 2. GH and prolactin co-secreting adenomas.
Inclusion Criteria:

 -  Diagnosis of acromegaly, and treated at the department of Endocrinology, Copenhagen
 University Hospital, Rigshospitalet, Denmark (tertiary referral hospital), surgical
 treatment of acromegaly

 Exclusion Criteria:

 -  no surgical treatment performed