Correlations Between Oxidative Stress Biomarkers, h-FABP and Left Ventricular Dysfunction in Patients With Acute Myocardial Infarction Undergoing Primary PCI
Correlations Between Oxidative Stress Biomarkers, h-FABP and Left Ventricular Dysfunction in Patients With Acute Myocardial Infarction Undergoing Primary PCI
The investigators intend to evaluate Oxidative Stress biomarkers through a. Catalase Activity
 Assay; b. Lipid Peroxidation Assay; c. SOD Assay; d. Total Antioxidant Capacity Assay; e.
 Glutathione Peroxidase at patients with acute myocardial infarction STEMI referred for
 primary PCI; The investigators also aim to evaluate cardiac necrosis by measuring Heart Fatty
 Acid Binding Protein (H-FABP), TnI, CK, CK-MB, LDH and AST in these patients with acute
 myocardial infarction referred for primary PCI; Also, the investigators intend to evaluate
 body composition through bioimpedance spectroscopy (BCM - Fresenius Care) at the moment of
 admission.

 The investigators aim to fully characterise these patients through oxidative millieu, hFABP
 and make correlations with LVEF dysfunction.
Gathered data:

 -  Descriptive general demographic data;

 -  Previous pathologies (ischemic heart disease, peripheral arterial disease, stroke, heart
 failure, previous percutaneous coronary interventions, coronary artery bypass grafting -
 CABG, known renal disease);

 -  Cardiovascular risk factors (age, weight, height, abdominal perimeter, body mass index,
 smoking, sedentariness, diabetes, hypertension, dyslipidaemia);

 -  Oxidative Stress biomarkers: Catalase Activity Assay; Lipid Peroxidation Assay; SOD
 Assay; Total Antioxidant Capacity Assay; Glutathione ;

 -  Cardiac necrosis markers: Heart Fatty Acid Binding Protein (H-FABP), TnI, CK, CK-MB, LDH
 and OGT;

 -  Routine biological data;

 -  Metabolic data (obtained from two body composition monitoring evaluations - before and
 12 hours after coronary intervention) - body water, body fat tissue;

 -  Information regarding primary PCI (less than 12 hours of ischemic symptoms);

 -  Coronarographic details, type of used stent, periprocedural specific complications,
 final TIMI - thrombolysis in myocardial infarction - flow);

 -  Echocardiography at admission (LVEF);

 -  Measurement of arterial stiffness through Sphigmocore pulsed-wave-velocity (24 hrs
 post-procedural, 2 velocities: carotid - femoral and carotid - radial);

 -  Calculating of cardiovascular risk scores: Syntax Score, Framingham score, ASSIGN score,
 QRISK2 score, PROCAM score, CRUSADE score, GRACE score, CHADS VASc score, MESA score,
 ASCVD score, Hamilton Depression Rating Scale (HAM-D), Hamilton Rating Scale for
 Anxiety;

 -  In-hospital and one month follow-up MACE.
Inclusion Criteria:

 -  Adults with ST elevation Myocardial Infarction (<12h) diagnostic confirmed;

 -  Included in the Romanian National Programme of Primary Percutaneous Revascularisation
 (for who the Guidelines recommend primary PCI);

 Exclusion Criteria:

 -  Patients who do not sign informed consent for primary PCI