Talc Outpatient Pleurodesis With Indwelling Catheter
Talc Outpatient Pleurodesis With Indwelling Catheter
This study will be a prospective, randomized trial comparing a new protocol to the standard
 of care. The investigators protocol and the standard of care involves a previously
 established procedure that will be completed in the investigators pulmonary procedure unit.
 The study will include using previously, well-established procedures (indwelling pleural
 catheter placement, talc slurry administration through an indwelling pleural catheter,
 pleuroscopy with talc poudrage administration) in addition to a new protocol (at home
 continuous drainage via indwelling pleural catheter).
The study design is a prospective, randomized and controlled trial comparing a new protocol
 to the standard of care. To the investigators knowledge, there is no similar protocol and
 this will be a single center, pilot study. The control arm will consist of subjects who meet
 the inclusion criteria for the study and will receive current standard of care management for
 paramalignant pleural effusion. This will consist of either an indwelling pleural catheter
 (IPC) placement with subsequent talc slurry administration and hospital admission for
 continuous drainage, or schedule medical pleuroscopy with talc insufflation poudrage and
 subsequent IPC placement for continuous drainage while in the hospital. The intervention arm
 will consist of subjects who meet the inclusion criteria and then will be scheduled for IPC
 placement in the pulmonary procedure unit as either an outpatient visit or during their
 hospital admission (if the subject is already admitted to the hospital and recruited via our
 inpatient consult service). The subjects in this arm will then go home or back to their
 original admission status with a drainage bag for continuous drainage on the same day as the
 procedure. This protocol will utilize a circuit with an IPC connected to a continuous
 drainage bag via a one-way Heimlich valve. It is important to note that while utilizing this
 circuit is a new protocol for patients with paramalignant pleural effusions, the protocol is
 the current standard of care practice for patients with pneumothorax and persistent air leak,
 and is being utilized regularly for these patients by the investigator's department as
 standard of care for patient needing long-term chest tubes while at home.
Inclusion Criteria:

 -  Age greater than or equal to 18 years old

 -  Diagnosis of a paramalignant pleural effusion (defined as a recurrent pleural effusion
 directly caused by malignancy with known thoracic involvement)

 -  Estimated life expectancy greater than 3 months

 -  Full lung re-expansion on chest x-ray after thoracentesis

 Exclusion Criteria:

 -  Age less than 18 years old

 -  Pregnant or lactating subject

 -  Any history of prior pleural talc administration

 -  History of an indwelling pleural catheter placed on the side of the active
 paramalignant pleural effusion

 -  Estimated life expectancy less than 3 months

 -  Active clinical heart failure

 -  Inability to return for frequent follow up appointments

 -  Current incarceration