Iron Sucrose in Patients With Iron Deficiency and POTS
Iron Sucrose in Patients With Iron Deficiency and POTS
This study aims to investigate whether the treatment of non-anemic iron deficiency with
 intravenous iron sucrose will result in decreased symptom reporting and improved
 cardiovascular indices in patients with Postural Orthostatic Tachycardia syndrome (POTS).
Inclusion Criteria:

 -  Patients (age 12 to years and older) with chronic (>3 months) symptoms of orthostatic
 intolerance, including but not limited to lightheadedness, syncope, headache, fatigue,
 weakness, sweating, nausea and heart palpitations.

 -  Symptomatic orthostatic heart rate increment ≥30 bpm if >19 years old or ≥40 bpm if
 <19 years old during a 10 minute 70 degree head up tilt study

 -  Presence of non-anemic iron deficiency, defined as serum ferritin levels <20 ug/L with
 hemoglobin no less than 1 gm/dL below the normal reference range as defined for age
 and gender

 -  Consent obtained from responsible guardian AND from subjects, 12-17 years of age

 -  Consent obtained for subjects 18 years of age and older

 Exclusion Criteria:

 -  Orthostatic hypotension (decrease of systolic BP>30 mmHg and/or diastolic BP>15mmHg
 within 3 minutes of 70 degree head up tilt study)

 -  Pregnant or lactating females

 -  The presence of failure of other organ systems or systemic illness that can affect
 autonomic function

 -  Concomitant therapy with anticholinergic, alpha-adrenergic antagonists,
 beta-adrenergic antagonists or other medications which could interfere with autonomic
 testing. Patients may participate if the potentially interfering medication is held
 for five half-lives prior to the study

 -  Laboratory evidence of anemia or iron overload

 -  Personal history of hematochromatosis or first degree relative with hematochromatosis

 -  Known sensitivity to Venofer® (iron sucrose injection, USP) or other intravenous iron
 preparation