Impact Of Bacterial Resistance On Healthcare Costs For Hospitalized Patients With Complicated Intra-Abdominal Infections
Impact Of Bacterial Resistance On Healthcare Costs For Hospitalized Patients With Complicated Intra-Abdominal Infections
The objective of this study is to estimate the costs of empiric antibiotic therapy and
 hospitalization costs for patients with a complicated intra-abdominal infection, and to
 assess the impact of treatment failure of initial antibiotic empiric therapy on
 pharmacological and total healthcare costs for these patients in Greece.
Every patient diagnosed with complicated intra-abdominal infections will enter the study,
 until the pre-specified number of patients is reached. Patients diagnosed with any of
 conditions mentioned below (inclusion criteria) will enter the study, until the pre-specified
 number of patients is reached.
Inclusion Criteria:

 -  A recorded primary diagnosis of a complicated intra-abdominal. infection (cIAI) and a
 procedure involving a laparotomy, laparoscopy, or percutaneous drainage of an
 intra-abdominal abscess The study will be a prospective, multi-centre, epidemiological
 study of patients (aged > 18 years) diagnosed with a complicated intra-abdominal
 infection AND who received a procedure involving laparotomy/laparoscopy or
 percutaneous drainage of an intra-abdominal abscess. cIAI's will include the following
 conditions/ diagnoses:

 -  Gastric ulcer with perforation;

 -  Gastric ulcer with hemorrhage and perforation;

 -  Duodenal ulcer with perforation;

 -  Duodenal ulcer with hemorrhage and perforation;

 -  Peptic ulcer with perforation;

 -  Peptic ulcer with hemorrhage and perforation;

 -  Gastrojejunal ulcer with perforation;

 -  Gastrojejunal ulcer with hemorrhage and perforation;

 -  Acute appendicitis with generalized peritonitis;

 -  Acute appendicitis with peritoneal abscess;

 -  Peritonitis;

 -  Abscess of intestine;

 -  Fistula of intestine, excluding rectum and anus;

 -  Ulceration of intestine;

 -  Perforation of intestine;

 -  Abscess of liver; or

 -  Acute cholecystitis with perforation.

 The initial antibiotic regimen will be defined as all IV antibiotics newly received either
 on the day immediately prior to laparotomy or laparoscopy or percutaneous drainage of an
 intra-abdominal abscess, or on the day of these procedures, given that the use of these
 procedures prior to initiation of IV antibiotic regimens in complicated IAIs , which is
 increasingly common, is likely reflective of prophylaxis.

 Exclusion Criteria:

 -  Patients not signing an informed consent form.

 -  Patients participating in another interventional study.