Immediate Effect of Proponent-Nasal-Spray on Unspecific Discomfort in the Nose
Immediate Effect of Proponent-Nasal-Spray on Unspecific Discomfort in the Nose
Investigation of the immediate effect on subjective relief of symptoms by Proponent - Nasal -
 Spray after a one time administration (following a single dose administration in each
 nostril) in an open, not randomised, non-blinded single centre observation study on 40
 volunteers between 18-75 years of age with an unspecific discomfort in the nose such as
 enhanced nasal discharge/ secretion (runny nose), congested nose, sneezing, itchy nose or
 feeling of a dry nose.
By regularisation of environment of nasal mucosa and the following restitution and
 improvement of the ciliary function the efficacy of mucociliary clearance can be remarkably
 enhanced, pathogens from the environment can be physically removed and a bacterial or viral
 infection may be prevented on this way.

 Such an optimizing effect may be reached by the administration of an equilibrated saline
 solution with an optimal composition regarding osmolality, pH-value and buffer substance.

 In addition it would be very advantageous to support the efficacy of the local unspecific and
 specific immune mechanisms in the nasal respiratory mucosa (NALT) without any negative
 effects on the optimized mucociliary clearance.

 As demonstrated recently in airway mucosa sodium propionate is able to interact with
 macrophages, the interleukin system and other factors of the TNF receptor family.

 Sodium propionate could therefore have an ancillary effect on the genuine immune mechanisms
 of nasal respiratory mucosa. On this way the primary effect of administration of saline
 solution is supported.
Inclusion Criteria:

 Key inclusion criteria are one or more of the following symptoms:

 -  nasal discharge/ secretion (runny nose)

 -  congested nose

 -  sneezing

 -  itchy nose

 -  feeling of a dry nose

 Exclusion Criteria:

 Key exclusion criteria:

 -  <18 years of age

 -  75 years of age