Protocol for High-Risk Assessment, Screening, and Early Detection of Pancreatic Cancer
Protocol for High-Risk Assessment, Screening, and Early Detection of Pancreatic Cancer
The purpose of this study is to find out whether Endoscopic Ultrasound (EUS) can detect early
 stage pre-cancerous or cancerous changes in the pancreas in patients at high-risk for the
 development of pancreatic cancer. Endoscopic refers to the use of an instrument called an
 endoscope - a thin, flexible tube with a tiny video camera and light on the end. Ultrasound
 refers to an imaging technique that uses sound waves to produce pictures. EUS in this
 research study is a method of combining endoscopy and ultrasound imaging to obtain high
 quality images of the pancreas.
Inclusion Criteria:

 -  Patients will be eligible if they have 2 or more relatives with pancreatic cancer and
 have a first degree relationship with at least one of the relatives with pancreatic
 cancer

 -  If only 2 family members are affected then both must have had pancreatic cancer
 and a first-degree relationship with individual screened

 -  If there are more than 2 affected individuals on the same side of the family at
 least one of the individuals must have a first-degree relationship with the
 member being screened

 -  Patients at least 40 years old or 10 years younger than the youngest affected
 individual

 -  Peutz-Jeghers Syndrome (PJS) patients age>30

 -  Hereditary pancreatitis patients

 -  Patients with Familial Atypical Multiple Mole Melanoma Syndrome (FAMMM)

 -  Patients with BRCA2 mutation and at least one first or second degree relative with
 documented pancreatic cancer

 -  Willingness to undergo (EUS) with possible Fine Needle Aspiration (FNA)

 -  Willingness to undergo surgical evaluation for abnormal EUS/FNA finding

 -  Willingness to undergo radiographic evaluation if screening findings are abnormal

 Exclusion Criteria:

 -  Medical contraindications to undergoing endoscopy or obstruction of the GI tract that
 precludes passage of the endoscope

 -  Personal history of pancreatic adenocarcinoma

 -  Previous partial or complete resection of the pancreas for adenocarcinoma

 -  Prior partial or total gastrectomy with Billroth II or Roux-en-Y anastamosis

 -  Previous computed tomography (CT) scan, magnetic resonance imaging/magnetic resonance
 cholangiopancreatography (MRI/MRCP) or EUS of the abdomen in the past 3 years

 -  Coexisting cancer in other organs or acquired immunodeficiency syndrome/human
 immunodeficiency virus (AIDS/HIV)

 -  Life expectancy less than 5 years

 -  Pregnancy