Probiotics for Prevention of Antibiotic Associated Diarrhea and Clostridium Difficile Associated Disease
Probiotics for Prevention of Antibiotic Associated Diarrhea and Clostridium Difficile Associated Disease
The study will evaluate if administration of probiotic Culturelle (Lactobacillus Rhamnosus
 GG) along with antibiotics can help decrease the occurrence of diarrhea caused by antibiotics
 as well as Clostridium difficile Diarrhea.
Inpatient adult males and females who are at least 18 years of age or older, undergoing
 treatment with antibiotics irrespective of indication and the type of antibiotics. The
 setting is an academic hospital.The patients are screened and potentially recruited upon
 initiation of antibiotic treatment regardless of indication for antibiotic prescription. The
 participants are patients being admitted to any inpatient units of the hospital for treatment
 with antibiotics. Exclusion criteria is:

 -  Diarrhea on admission or within the preceding week

 -  Reported recurrent diarrhea

 -  Bowel pathology that could result in diarrhea (including preexisting Inflammatory Bowel
 disease{IBD}, all forms for colitis or any other condition resulting in preexisting
 diarrhea)

 -  Intake of high risk antibiotics (clindamycin, cephalosporins, aminopenicillins→ well
 known to cause CDAD) and or more than two courses of other antibiotics in the past four
 weeks to exclude pre-existing diarrhea associated with antibiotic use

 -  Immunosuppression (Chronic steroid use, Active chemotherapy, Active radiotherapy, HIV or
 any other disorder resulting in a compromise in participants immune status)

 -  Bowel surgery causing liquid stools

 -  Regular probiotic intake before admission

 -  Lactose intolerance or intolerance to dairy products.
Inclusion Criteria:

 -  Inpatient adult males and females who are at least 18-89 years of age, undergoing
 treatment with antibiotics irrespective of indication and the type of antibiotics.

 Exclusion Criteria:

 -  Diarrhea on admission or within the preceding week

 -  Reported recurrent diarrhea

 -  Bowel pathology that could result in diarrhea (including preexisting Inflammatory
 Bowel disease{IBD}, all forms for colitis or any other condition resulting in
 preexisting diarrhea)

 -  Intake of high risk antibiotics (clindamycin, cephalosporins, aminopenicillins→ well
 known to cause CDAD) and or more than two courses of other antibiotics in the past
 four weeks to exclude pre-existing diarrhea associated with antibiotic use

 -  Immunosuppression (Chronic steroid use, Active chemotherapy, Active radiotherapy, HIV
 or any other disorder resulting in a compromise in participants immune status)

 -  Bowel surgery causing liquid stools

 -  Regular probiotic intake before admission

 -  Lactose intolerance or intolerance to dairy products