Laparoscopic Versus Open Right Hemicolectomy Within ERAS in Right-sided Colon Cancer
Laparoscopic Versus Open Right Hemicolectomy Within ERAS in Right-sided Colon Cancer
In this study, the investigators have compared the clinical outcomes of the laparoscopic and
 open right hemicolectomy within enhanced recovery after surgery (ERAS) programs in the
 treatment of right-sided colon cancer.
This study was a prospective, single-center, randomized control trial. Including criteria
 were (1) Age between 18 and 75 years; (2) Histologically confirmed right-sided colon
 adenocarcinoma；(3) Clinical stage I-III; (4) Performance status (ECOG) 0-1; (5) Adequate
 hematological, hepatic and renal function. Patients operated on as an emergency, or with
 tumours in the transverse colon, or with other previous malignancy within 5 years were
 excluded.

 All particapants were recruited and randomly assigned to receive 3D-laproscopic or open right
 hemicoloectomy. All patients were treated with an ERAS protocol. The primary end-point was
 the incidence of postoperative complications within 30 days. Complications were diagnosed and
 classified according to the Clavien-Dindo classification. The secondary end-points were ERAS
 adherence, readmissions, reoperations, hospital length of stay, mortality, and survivals. The
 study was approved by the Ethics Committee of Zhongshan Hospital, Fudan University, Shanghai,
 China. Written informed consent was obtained for patients to participate the study. This
 study followed the Consolidated Standards of Reporting Trials (CONSORT) reporting guideline.
Inclusion Criteria:

 1. Age ≥ 18 and ≤ 75 years;

 2. Primary tumor has undergone histologically confirmed right-sided colon adenocarcinoma;

 3. Together with clinical or radiological evidence of Stage(T1-2,N0, M0) Stage II (T3-4,
 N0, M0) or Stage III (T1-4, N1-2, M0) disease (according to the 2007 revision of the
 International Union Against Cancer TNM staging system)

 4. Performance status (ECOG) 0~1

 5. Adequate hematological function: Neutrophils≥1.5 x109/l and platelet count≥100 x109/l;
 Hb ≥9g/dl (within 1 week prior to randomization)

 6. Adequate hepatic and renal function: Serum bilirubin≤1.5 x upper limit of normal
 (ULN), alkaline phosphatase ≤5x ULN, and serum transaminase (either AST or ALT) ≤ 5 x
 ULN(within 1 week prior to randomization);

 7. Written informed consent for participation in the trial.

 Exclusion Criteria:

 1. Other previous malignancy within 5 years, with exception of a history of a previous
 basal cell carcinoma of the skin or pre-invasive carcinoma of the cervix

 2. Pregnancy (absence confirmed by serum/urine β-HCG) or breast-feeding

 3. Known drug abuse/ alcohol abuse

 4. Legal incapacity or limited legal capacity

 5. Pre-existing peripheral neuropathy.