CSII in Type 1 Diabetes: Diet, Quality of Life & Cardiometabolic Risks - A Longitudinal Study
CSII in Type 1 Diabetes: Diet, Quality of Life & Cardiometabolic Risks - A Longitudinal Study
Glycaemic control is an important aspect of Type 1 diabetes (T1D) management for
 diabetologists and patients alike. Evidence suggests continuous subcutaneous insulin infusion
 (CSII) is an effective method of achieving this. Among the advantages of CSII is the
 opportunity for patients to potentially discard relatively inflexible mealtimes and
 carbohydrate requirements imposed by other regimes such as multiple daily injections (MDI).
 There are also reported improvements in quality of life. Furthermore, in patients with good
 glycaemic control, such as those often assisted by CSII, various qualitative atherogenic
 lipid abnormalities may exist, despite the presence of a normal quantitative lipid profile;
 potentially leading to increased cardiometabolic risks. Literature examining the eating
 behaviours, quality of life and cardiometabolic risks of CSII patients over time after
 commencement of the therapy is sparse, frequently dated and worthy of further research.
Continuous subcutaneous insulin infusion (CSII) is a therapy for patients with Type-1
 diabetes mellitus involving insulin administration via electronic pump. CSII has been shown
 to reduce HbA1c levels and improve blood sugar control and the continuous, unobtrusive
 insulin delivery may potentially allow patients increased dietary flexibility and quality of
 life. However, despite these claims longitudinal investigatory literature is sparse. This
 study will clarify whether adult CSII patients experience eating behaviour and quality of
 life alterations over time after commencement of the therapy. This is important as changes
 may be associated with cardiometabolic risk variations; which will also be investigated.

 Participants will comprise of a convenience sample of adults with Type-1 diabetes invited
 from diabetes clinics at the Royal Liverpool University Hospital who are due to commence
 CSII.

 Following ethical consent the participants who are due to commence CSII will be observed at 5
 time points (every three months) over a year. It should be noted that the recruitment period
 for the longitudinal arm of the study will be 9 months starting from the date the first
 participant is recruited. At each time point each participant will be asked to complete a 5
 day food diary, a food intake questionnaire (FIQ), a quality of life (QOL) questionnaire, a
 semi-structured interview and give a 20ml sample of blood. This will be taken at the same
 time and in addition to their regular diagnostic sample, however where this is unfeasible
 extra occasional appointments may be needed. Results will be compared with existing patient
 medical records, which will also be analysed during the study.
Inclusion Criteria:

 -  Patients must reside in Liverpool or the surrounding areas.

 -  Patients must be ages over 18

 -  Patients must have Type 1 diabetes

 -  Patients must be using or pending the supply of an insulin pump.

 Exclusion Criteria:

 -  Patients must not live outside of Liverpool and the surrounding areas.

 -  Patients must not be aged under 18