TTP and aHUS in Complicated Pregnancies
TTP and aHUS in Complicated Pregnancies
A single site observational study aiming to:

 (i) Identify cases of previously undiagnosed thrombotic thrombocytopenic purpura (TTP) and
 atypical haemolytic syndrome (aHUS) in a cohort of women with complicated pregnancies (ii)
 Characterise the clinical features of these cases and (ii) Identify clinical features or
 biomarkers which may help distinguish TTP/aHUS from other complications of pregnancy such as
 preeclampsia
Inclusion Criteria:

 - Women, either currently pregnant or recently postpartum, and affected by one or more of
 the following complications in the index pregnancy: (i) Preeclampsia with evidence of end
 organ damage (renal/ liver/ haematological/ neurological) or uteroplacental dysfunction
 (FGR/IUFD) (ii) HELLP syndrome (iii) Fetal growth restriction (FGR) (growth <10th centile)
 that is unexplained (ie not due to infection, fetal structural anomaly, fetal chromosomal
 or pre-existing maternal medical problem) (iv) Intrauterine fetal demise (IUFD) after 20
 weeks' gestation that is unexplained (v) Unexplained new onset renal impairment (defined by
 serum creatinine >85umol/L 1st trimester, or >80umol/L 2nd trimester, or >90 umol/L 3rd
 trimester[32]; OR an increase in serum creatinine by (i) at least 1.5 times the baseline or
 (ii) of equal or greater than 26.5umol/L (as per KDIGO criteria) (vi) Unexplained new onset
 thrombocytopenia (platelets <75x10^9/L)

 Exclusion Criteria:

 -  Previous diagnosis of TTP or aHUS

 -  Known disorder of complement dysregulation

 -  Patients not wishing to participate

 -  Patients aged less than 16

 -  Patients lacking capacity to provide informed consent