Effect of Irradiation of the Cavernous Sinus and the Sellar Region on Autobiographical Memory
Effect of Irradiation of the Cavernous Sinus and the Sellar Region on Autobiographical Memory
Several studies showed that radiotherapy as brain tumors treatment may affect cognition. It
 was observed that durable memory impairments could arise at irradiated patients if
 radiotherapy is applied on medial temporal lobes.

 However, results concerned studies of anterograde memory and none, this day, estimates the
 impact of radiotherapy on autobiographical memory which also involves hippocampus.

 The aim of this study is to evaluate effects of cavernous sinus or sellar region irradiation
 on autobiographical memory.

 Thirty 35 to 65 years old patients, with cavernous sinus meningioma or pituitary adenoma for
 who radiotherapy is indicated will be recruited.
Several studies showed that radiotherapy as brain tumors treatment may affect cognition. It
 was observed that durable memory impairments could arise at irradiated patients if
 radiotherapy is applied on medial temporal lobes. However, results concerned studies of
 anterograde memory and none, this day, estimates the impact of radiotherapy on
 autobiographical memory which also involves hippocampus, as specified in Nadel and Moscovitch
 model, the Multiple Trace Theory.

 Autobiographical memory impairment issue is fundamental for identity construction. Prevent
 those impairments is important to quality of life improvement after such treatments.

 The aim of this study is to evaluate effects of cavernous sinus or sellar region irradiation
 on autobiographical memory.

 A pilot study was conducted with 10 patients affected by left cavernous sinus meningioma
 divided in two groups: the first one with untreated patients and the second one with patients
 who received cavernous sinus irradiation between 2 and 5 years before pilot study. This study
 indicated autobiographical memory deterioration in two groups and a worsening in treated
 group. Study limits did not allow us to draw conclusions. That is why, sample size will be
 extended and patients with cavernous sinus meningioma or pituitary adenoma will be recruited
 because of proximity between cavernous sinus, pituitary gland and hippocampus. Investigators
 wish to recruit 30 patients with cavernous sinus and meningioma.

 Investigators hope for confirm our results from pilot study.
Inclusion Criteria:

 -  Age between 35 and 65.

 -  Patient with:

 -  meningioma of the cavernous sinus for which radiotherapy is planned

 -  or a pituitary adenoma for which radiotherapy is planned

 -  French Mother tongue

 -  Person affiliated to national insurance

 -  Person who give its verbal agreement to participate

 Exclusion Criteria:

 -  Presence of a serious psychiatric disorder (major depression, psychotic disorders,
 etc.) and central nervous system disease (epilepsy, multiple sclerosis, etc.).

 -  Treatment with chemotherapy

 -  General intellectual abilities deficient (IQ <80)

 -  Extension front of their meningioma

 -  Deficient Language Skills.