Endarterectomy vs Stenting in Chinese Asymptomatic Carotid Stenosis Patients
Endarterectomy vs Stenting in Chinese Asymptomatic Carotid Stenosis Patients
Endarterectomy vs Stenting Asymptomatic Carotid stenosis patients to verify the efficacy and
 safety.
Endarterectomy vs Stenting Asymptomatic Carotid stenosis patients to verify the efficacy and
 safety.Study Design is a prospective, multiple center, randomized controlled trail.600 cases
 enrollment predict，each group including carotid artery stenting and carotid endarterectomy
 300 cases.Follow-up period of 2 years.
Inclusion Criteria:

 Clinical Criteria

 1. Age≥50 years，sex unlimited；

 2. Asymptomatic carotid stenosis ，ie no transient ischemic attack、stroke or other related
 neurological symptom caused by carotid stenosis in the past 6 months.(Only the
 clinical manifestations of dizziness or mild headache are considered asymptomatic
 carotid stenosis.)；

 3. The patient understands the trial objective，understands and accepts the duration of
 the study，is able and willing to comply with all requirements，including follow-up and
 evaluation of it, voluntarily participates in the study and signs Informed Consent
 Form.

 Anatomy Criteria

 4. Internal carotid artery independent disease.（ Involving or not involving adjacent
 common carotid arteries is permitted.）；

 5. Carotid stenosis satisfies one of the following criteria ：

 1. Ultrasonography suggests stenosis ≥ 70%，or angiography showed stenosis ≥ 60%；

 2. Ultrasonography suggests stenosis < 70%，but angiography or other examination
 showed stenosis in an unstable state；

 6. Patients with bilateral carotid stenosis, the treatment time for target vessel
 contralateral vessels is required 30 days before enrollment or 30 days after
 completion of study procedure；

 7. The stent can reach the site of lesion smoothly as expected.

 Exclusion Criteria:

 -  Clinical Criteria

 1. Patients with progressive stroke in the past 3 months or recent (Within 7 days)，
 CT or MRI suggested that the lesion is large，and may be with the risk of
 hemorrhagic transformation；

 2. Patients with anesthesia contraindications；

 3. Serious ipsilateral stroke occurred in the past and may confuse the judgment of
 the study endpoint；

 4. Patients with severe dementia；

 5. Patients with spontaneous intracerebral hemorrhage in the past 12 months；

 6. Large size of cerebral infarction or myocardial infarction occurred within 30
 days ；

 7. Patients with large intracranial aneurysms (diameter> 5mm)，and cannot be treated
 in advance or contemporaneous；

 8. Chronic total occlusion without obvious cerebral ischemia symptoms；

 9. Hemoglobin <100 g/l， Platelet count <125×109/L， INR>1.5， Bleeding time > 1
 min，patients with exceeding the upper limits of normal，or heparin-related
 thrombocytopenia；

 10. Patients unable to perform normal angiographic evaluation or unsafe percutaneous
 puncture point；

 11. Patients with neurologic disorder that caused transient or permanent neurological
 deficits within 2 years before the surgery and can not be identified with
 transient ischemic attack or stroke；

 12. Patients with other cardiac emboli sources, such as left ventricular aneurysm,
 intraluminal filling defect, cardiomyopathy, aortic or mitral prosthetic heart
 valve, calcific aortic stenosis, infective endocarditis, mitral stenosis, atrial
 septal defect, atrial septal aneurysm, or left atrial myxoma；

 13. Recent gastrointestinal bleeding and affects antiplatelet therapy；

 14. Surgical contraindications or patients with high risk of surgery defined as
 having any of the following： It is known that two or more proximal or main
 coronary artery stenosis ≥70%, untreated or unable to pass； Ejection fraction
 <30% or New York Heart Association (NYHA) functional class III or higher；
 Unstable angina，ie angina at resting state and electrocardiogram changes；
 Currently waiting main organ transplants (ie heart, lung, liver, kidney), or are
 doing relevant evaluate； Malignant tumor or respiratory insufficiency, life
 expectancy < 5 years or forced expiratory volume at one second < 30% (predicted)；
 Dialysis-dependent renal failure； Poor control of diabetes, fasting blood glucose
 >22mmol/L and ketone body > +2； Need to perform other general anesthesia during
 the same period；

 15. There may be one or more anatomical conditions affecting the normal operative
 approach in patients with contraindications for carotid endarterectomy operation；
 there may be one or more anatomic situations to increase the risk of adverse
 events in patients with high operative risk；including： Neck radiation therapy
 history； Radical neck surgery history； Inoperable lesions (ie more than C2
 lesions)； Spinal brake - unable to bend neck, or kyphotic deformity； Symptomatic
 dissection of the carotid siphon below； Common carotid artery opening
 lesion；present tracheotomy； Contralateral recurrent laryngeal nerve paralysis；
 Previously performed ipsilateral carotid endarterectomy，intracranial or
 subclavian arterial bypass surgery； Contralateral carotid artery occlusion；
 Lesions series； Severe long segment calcification of the carotid artery；
 Inaccessible lesions by endoluminal methods (Severe distortion of the aortic arch
 branch, no suitable introduction of arteries, aortic arch anatomy special）；

 16. Investigators consider the patient inappropriate to participate in this clinical
 trial；

 17. Those who participated in clinical trials of other drugs or medical devices
 before the inclusion did not reach the end of the time limit.

 Angiography criteria

 18. Severe vascular tortuosity, or anatomical conditions may affect the safe
 locomotion of guide catheter, guide sheath or stent；

 19. Patients with ipsilateral carotid artery stenting or having a graft；

 20. Patients with severe or extensive arteriosclerosis, involving the aortic arch and
 the proximal common carotid artery, causing locomotion danger of guide catheter
 or guide sheath；

 21. Carotid endarterectomy contraindications by angiography：severity of intracranial
 or extracranial arterial stenosis that exceeds target lesions; cerebrovascular
 arteriovenous malformations; or other contraindications;

 22. Patients with contralateral carotid artery stenosis, are expected to be performed
 within 30 days of the perioperative period of the study；

 23. Occlusion.