Probiotics in Hospitalized Patients Study
Probiotics in Hospitalized Patients Study
The purpose of this study is to compare the effect of enhanced probiotic (EP, Live Rx) versus
 placebo (PL) on the incidence of Clostridium difficile associated diarrhea (CDAD) or
 antibiotic associated diarrhea (AAD) in hospitalized patients initiated on antibiotics.
Inclusion Criteria:

 -  18 years of age or older admitted to SSH and prescribed antibiotics for an expected
 duration >3 days (may include patients on antibiotics prior to admission).

 Exclusion Criteria:

 -  1. History of chronic diarrhea illness (Irritable Bowel Disease (IBD), Irritable Bowel
 Syndrome (IBS), Celiac Disease, Chronic pancreatitis 2. Diarrhea at screening 3.
 Active Colitis of any etiology 4. History of colectomy 5. Regular consumption of
 probiotics within 72 hours 6. Unable to provide written consent 7. History of or
 active pancreatitis 8. Severe Sepsis or Septic Shock (sepsis with end organ failure
 e.g. renal failure, ARDS, MS changes and or meets criteria by n ational guideline, and
 or requiring vasopressors) 9. Hypersensitivity to any ingredient in probiotic product
 10. Severe Immunosuppression (ANC <1000, AIDS/CD4 count <200 cells, cancer on active
 chemothereapy, h/o of solid or bone marrow transplant) 12. Acute burn injuries