MICRO-RNAs OF NEUTROPHILS IN RENAL ANTINEUTROPHIL CYTOPLASMIS ANTIBODY (ANCA) -ASSOCIATED VASCULITIS
MICRO-RNAs OF NEUTROPHILS IN RENAL ANTINEUTROPHIL CYTOPLASMIS ANTIBODY (ANCA) -ASSOCIATED VASCULITIS
Activation of neutrophils by ANCA ("Anti-Neutrophil Cytoplasm Antibodies") and subsequent
 microvascular endothelial cell damage is the main feature of ANCA-associated vasculitis
 (AAV), a severe autoimmune disease that often targets the kidney. There is no specific
 treatment for AAV to date and 25% of patients with renal damage evolve towards end-stage
 renal disease, requiring dialysis and kidney transplantation. In addition, there is no
 reliable biological marker of the disease activity available, which makes the diagnostic,
 follow-up and treatment of patients difficult. Therefore, the identification of new
 therapeutic targets and non-invasive biomarkers constitutes a major clinical challenge to
 improve AAV patients care and to ameliorate their renal outcome.
Inclusion Criteria for patients:

 -  Adult patients aged over 18 years

 -  Patients with Granulomatosis with polyangiitis or microscopic polyangiitis meeting the
 criteria of Chapel Hill.

 -  corticosteroid treatment <20 mg / day.

 -  Informed consent: oral for participation in research and writing for biological
 collection.

 Inclusion Criteria for controls patients:

 - healthy-topics matched for age, recruited from the Etablissement français du sang or in
 the Department of Internal Medicine of Nantes University Hospital

 Non Inclusion Criteria:

 -  ANCA-associated vasculitis with Eosinophilic granulomatosis with polyangiitis
 (AAV-EGPA).

 -  Infectious or progressive tumor pathology.

 -  Pregnancy, lactation

 -  Treatment with cyclophosphamide in the 6 months prior to inclusion.

 -  Terminal chronic renal failure, presence of organ allograft.

 -  Thrust Patients receiving corticosteroids> 20 mg / d in the previous 4 weeks.

 -  Inability to give informed about information (subject in emergencies, understanding of
 the subject of difficulty, ...)

 -  Minor subject, under judicial protection, guardianship