Treatment for Obstructive Sleep Apnea Hypopnea Syndrome and Obesity Hypoventilation Syndrome (OHS)
Treatment for Obstructive Sleep Apnea Hypopnea Syndrome and Obesity Hypoventilation Syndrome (OHS)
Sleep Apnea Hypopnea Syndrome (OSAHS), is common in patients with OHS, compared to single
 Obesity Hypoventilation Syndrome (OHS) or OSAHS ,patients with both of them are more
 susceptible to have serious hypoxia and carbon dioxide retention during sleep, and much more
 likely to result in pulmonary hypertension and cor-pulmonale.

 At present, the most widely and valid method for these patients is the Bilevel Positive
 Airway Pressure (BiPAP) ventilation, while, recently, the investigators discovered a
 completely novel device, namely auto-trilevel Ventilator. In contrast to the traditional
 therapy, auto-trilevel Ventilator has a more flexible expiratory positive airway pressure
 (EPAP), with which it can removing residual obstructive sleep apnea hypopnea events and
 correcting hypercapnia without contradiction. Treated with auto-trilevel ventilator may delay
 the progression of disease and improve life quality. The overall purpose of this study is to
 determine the curative effects of auto-trilevel ventilators on patients with OHS and OSAHS.
The main contradiction in treatment for OSAHS complicated OHS is how to improve hypercapnia
 because of narrower difference between inspiratory positive airway pressure (IPAP) and
 expiratory positive airway pressure (EPAP), and meanwhile to eliminate apnea and popnea
 events which may easily occur at the end of expiration For ordinary Bipap ventilator. If the
 IPAP is set to higher, the patients may feel discomfort, if the pressure difference between
 IPAP and EPAP is too narrow or the expiratory positive airway pressure (EPAP) too high,
 hypercapnia may occur. If the EPAP is too low, redusual apnea and hypopnea event may become
 common.

 Auto-trilevel ventilation, with a lower airway pressure at the beginning of expiration to
 prevent hypercapnia and a higher airway pressure at the end of expiration to prevent residual
 apnea events, should be able to provide a novel ventilation mode with a higher efficacy and
 lower average airway pressure for OSAHS patients complicated with OHS. To prove the
 hypothesis, comparison is made between ordinary BiPAP and auto-Trilevel ventilation modes
 during treatment for patients with OSAHS and OHS.

 In this study, the investigators compare the changes of related indexes (including apnea
 hypopnea index、minimal pulse oxygen saturation、arousal index, sleep quality,PaCO2 and
 sleepiness scores) before and after treatment. Meanwhile, curative effects will be compared
 between BiPAP and auto-Trilevel ventilation modes. The investigators will analyze the changes
 and then confirm our hypothesis.
Inclusion Criteria:

 1. Patient or legal representative of the patient is willing and able to sign an approved
 informed consent and privacy protection authorization in the United States.

 2. Subject is >18 years old.

 3. Diagnosed OHS and OSAHS:

 4. Expected to tolerate the ventilator therapy.

 Exclusion Criteria:

 1. Patient is currently enrolled in another clinical study which may confound the result
 of this study.

 2. Patient for whom inform consent cannot be obtained.

 3. Patients with a history of cerebrovascular accident within the 6 months prior to this
 study.

 4. Patients with acute or chronic renal failure, diabetes and severe lung diseases.

 5. Patients with unstable angina.

 6. Patient who is of pregnant or during lactation period.

 7. Patients with a history of injury or surgery within 6 months prior to the study