Proactive Community Case Management for Malaria in Zambia
Proactive Community Case Management for Malaria in Zambia
To study if a proactive strategy of weekly household visits by community health workers
 (CHWs) to identify people with malaria symptoms, offer diagnostic testing, and treatment for
 those with positive tests in Chadiza District, Eastern Province, can decrease malaria
 incidence and prevalence compared to conventional community case management.
This study will be a two arm, cluster-randomized controlled trial to determine whether year
 round weekly household visits by CHWs to detect and test people of all ages with fever or
 history of fever with RDTs (and offer diagnosis and referral or treatment of diarrhea and
 pneumonia for children under 5 years), and offer treatment with an ACT for those who test
 positive compared to standard passive iCCM by CHWs (which includes malaria case management
 for all ages in Zambia), is associated with a greater reduction in confirmed malaria cases
 and parasite prevalence over a 2-year follow-up period.

 Randomization will occur at the level of the CHW catchment areas. Thirty-three clusters will
 be enrolled in each arm for a total of 66 clusters. Primary study outcomes will be evaluated
 based on household-level cross-sectional surveys conducted at baseline and end-line and
 confirmed malaria case data collected through the health system throughout the study period.

 Primary objectives:

 1. Assess whether year-round weekly proactive iCCM compared to passive iCCM with malaria
 case management for all ages reduces the prevalence of patent (by rapid diagnostic test
 (RDT)) and subpatent (by PCR) parasitemia detected at the household level in cross
 sectional household surveys.

 2. Determine whether the confirmed malaria case incidence (detected by CHWs (either
 proactively or passively) and at health facilities) decreases over time in communities
 with weekly proactive iCCM compared to passive iCCM by comparing the difference in slope
 of confirmed malaria incidence in proactive vs routine arms using an interrupted time
 series analysis

 Secondary objectives:

 1. Assess whether access to care (proportion of the population with fever in the past two
 weeks who received care from a qualified health provider, including community health
 worker), promptness of care (within 24 and 48 hours of symptoms), access to diagnostic
 malaria testing (proportion of the population with fever in the past two weeks who
 received a diagnostic test for malaria), and treatment with artemisinin-based
 combination therapy (ACT) if RDT is reported positive, is improved by proactive iCCM
 compared to passive iCCM

 2. Describe the incidence of febrile disease, by arm, as well as the incidence of
 symptomatic malaria infection (febrile persons with a positive RDT), detected during
 proactive iCCM visits

 3. Compare the incidence of malaria, by arm, detected at health facilities

 4. Compare the proportion of malaria cases detected at community vs health facility, by arm

 5. Determine if proactive iCCM reduces severe disease (malaria in all ages, diarrhea and
 pneumonia among < 5) compared to passive iCCM identified at health facility and
 community level)

 6. Compare level of parasite exposure in intervention and control arms using multiplex bead
 based assay for long, medium and short duration antibodies

 7. Determine programmatic cost per additional case detected and treated at the community
 level with proactive iCCM

 8. Describe the feasibility, challenges, and benefits of proactive iCCM from the
 perspective of the facility health worker, CHW, and community members

 9. Describe the benefits and challenges associated with incorporating diagnosis and
 treatment of pneumonia and diarrhea for children under 5 years
All residents of all ages in the study area will be eligible to receive the CHW
 intervention.

 All ages with fever