Depressed Adolescents Treated With Exercise (The DATE Study)
Depressed Adolescents Treated With Exercise (The DATE Study)
This study will evaluate whether standardized aerobic exercise is an effective treatment for
 depression in adolescents.
Major depressive disorder (MDD) is a disabling form of depression in which sadness and
 inability to feel pleasure prevent people from living their normal lives. MDD is common in
 adolescents, and depression experienced early in life can lead to long-term psychological and
 social impairment or suicide. Studies of depressed adults show that regular aerobic exercise
 can result in recovery from mild to moderate MDD. Studies also show that adolescents who
 exercise regularly have lower rates of depression, but no randomized, controlled studies have
 examined exercise as a treatment for depression in adolescents. This study will compare a
 standardized aerobic exercise routine to a stretching control group to determine whether
 aerobic exercise is an effective treatment for MDD in adolescents.

 Participation in this study will last 12 weeks, with follow-up interviews taking place after
 6 and 12 months. Participants will first undergo screening procedures, during which
 adolescent participants and their parents will complete interviews and questionnaires about
 the adolescent's mood and behavior. Participants will also need to provide physician-written
 letters confirming that they are healthy enough to participate in the exercise program. After
 screening, participants will be randomly assigned to either an exercise program or a
 stretching program. At the first study visit, a course of exercise or stretching will be set
 for each participant. Participants in both groups will spend the same amount of time doing
 physical activity. They will complete three to four exercise or stretching sessions per week
 for 12 weeks, with each session lasting 20 to 30 minutes. Participants will be able to
 complete some sessions at home, but they will need to return to the study exercise center for
 weekly study visits. At these study visits, participants will be weighed to determine if the
 level of exercise needs to be adjusted, and they will complete questionnaires about their
 depression. Over the course of the study, participants will wear a wrist-watch-like device
 called an Actical, which will monitor energy use. Participants will also undergo heart rate
 monitoring while exercising and complete an exercise log online. A set of questionnaires and
 interviews similar to those at screening will also be repeated at 6- and 12-month follow-ups.
Inclusion Criteria:

 -  Diagnosis of nonpsychotic major depressive disorder at least 4 weeks prior to study
 entry

 -  Clinical Global Impression-Severity (CGI-S) score of 4 or greater

 -  Children's Depression Rating Scale (CDRS) score of greater than 35 but less than 71

 -  Currently attending school

 -  Willing and able to use acceptable methods of contraception, if applicable

 -  A signed letter from family physician verifying physical health necessary for
 participation in the exercise program

 -  Response to the Physical Activity Readiness Questionnaire (PAR-Q) indicates that no
 conditions are present that would render exercise inappropriate

 -  Speaks and reads English

 -  Parent or guardian willing to provide informed consent, if applicable

 Exclusion Criteria:

 -  Severe suicidal ideation

 -  History of psychotic disorders

 -  Alcohol or substance abuse or dependence within 6 months of study entry

 -  History of anorexia nervosa or bulimia

 -  Chronic medical illness requiring regular medication

 -  Pregnant

 -  Currently participating in a vigorous exercise program or activity, defined as 30
 minutes of vigorous physical activity five times per week

 -  IQ less than 70