Changes in Serum Vitamin D Level After Different Loading Doses of Cholecalciferol
Changes in Serum Vitamin D Level After Different Loading Doses of Cholecalciferol
it is a clinical trial to observe increase in serum vitamin D level and clinical symptoms
 after 3 different doses of cholecalciferol given either intramuscularly or oral.
A prospective, interventional study was conducted in Department of Rheumatology, BSMMU,
 Dhaka, Bangladesh from October 2015 to January 2017. One hundred and five clinically healthy
 adults of age 21-39 with serum vitamin D concentration were enrolled in the study. Serum
 vitamin D level was estimated by chemiluminescent micro particle immunoassay method at
 baseline and 3 months after the intervention. The participants were divided into three groups
 using random number table. Group A was given 6 lakh IU of cholecalciferol IM stat dose, group
 B was given 6 lakh IU of cholecalciferol orally with a glass of milk stat dose and group c
 was given 2 lakh IU of cholecalciferol orally once a month for 2 months followed by tablet
 cholecalciferol 1000 IU daily.
Inclusion Criteria:

 -  hypovitaminosis D (serum 25 OH D < 20 ng/ml)

 Exclusion Criteria:

 -  Chronic disease causing Vitamin D deficiency like CKD, nephrotic syndrome, liver
 disease, hyperparathyroidism, history of skin graft, malabsorption, hyperthyroidism,
 drugs like anticonvulsants, glucocorticoids, HAART Current pregnancy Lactose
 intolerance Previously treated with bolus Vitamin D supplementation within previous
 three months