Interest of the Donor-specific Antibodies After Liver Transplantation
Interest of the Donor-specific Antibodies After Liver Transplantation
The study is a prospective observational mono center study

 Primary objective :

 Study the anti-HLA antibodies frequency preformed before liver transplantation and the
 kinetic of appearance of DSA and de novo complement-binding anti-HLA antibodies after liver
 transplantation.

 Secondary objective :

 -  Risk factor of de novo DSA appearance (Immunosuppressive therapy, liver aetiology)

 -  Impact of DSA on:

 -  Graft and patients survivals

 -  Onset of allograft rejection (acute, late-onset, chronic)

 -  Unexplained liver graft dysfunction

 -  Unexplained liver enzymes abnormalities

 -  Liver fibrosis development (liver stiffness study using fibroscan©)
Inclusion Criteria:

 -  Liver transplanted patients older than 18, transplanted in Lille University Hospital.

 -  Written consent by the patient or his/her legal representative (especially patient
 with hepatic encephalopathy).

 -  Patients with health insurance

 Exclusion Criteria:

 -  Minor patients.

 -  Pregnant women or during lactation.

 -  Patient under curatorship.