Growth Hormone Secretion Following the Anaerobic Exercise
Growth Hormone Secretion Following the Anaerobic Exercise
Proper growth in children is a complex process regulated by a combination of genetic,
 nutritional, environmental, hormonal, and others. Growth hormone (GH) is the main hormone
 regulating the growth from childhood to adulthood. Despite great progress in the field, with
 the development of recombinant GH for the treatment of growth hormone deficiency (GHD), there
 is still no reliable method for testing GHD. Physical exertion is one of the significant
 physiologic stimuli for GH secretion, and it is reliable test for identification of GHD. It
 is not in use in the clinics because of its complexity. Recently GH secretion following short
 anaerobic exercise in young adults was tested and also demonstrated significant growth
 hormone secretion

 In contrast to adult children's exercise is characterized by an anaerobic nature. There is no
 data about secretion of growth hormone in response to anaerobic exercise in children.

 Purpose of the experiment:

 The purpose of this study is to evaluate the secretion of growth hormone in response to
 anaerobic exercise in children.
100 children aged 6-16 years, followed at the pediatric endocrinology clinic for growth
 assessment or obesity. Assessment of their growth hormone axis will be evaluate in parallel
 according to the currently accepted pharmacological GH testing as accepted and also following
 anaerobic physical test.

 After explanation to the patient and his parent and obtaining an informed consent, the
 children will be instructed to pedal at maximum speed for 15 seconds x 10 sprints (1 minute
 of recovery between the sprints) against a resistance adjusted according to their body mass
 index.

 The test will perform in similarity to GH provocative protocols by mean that they will be
 performed in the morning after a night's sleep and overnight fasting. The patients will be
 remained fasting during the test.

 They will be asked not to exercise a day before the test. Thirty minutes before the test,
 Venflon will be inserted and the child will receive an explanation and rest until the
 beginning of the test. blood GH, IGF-1, cortisol will be taken at the beginning of exercise
 (time 0), at the end of exercise, after 30 minutes, 45 minutes and 60 minutes is customary
 according to criteria set pharmacological inventory growth hormone.

 The test results will be compared to pharmacological testing of the child if available.
Inclusion Criteria:

 -  Children evaluated for short stature

 -  Normal weight \ overweight \ obesity

 Exclusion Criteria:

 -  Known GH deficiency