Near Infrared Fluorescence Cholangiography (NIRF-C) During Cholecystectomy
Near Infrared Fluorescence Cholangiography (NIRF-C) During Cholecystectomy
The purpose of this study is to evaluate an imaging system using Indocyanine Green (ICG) to
 assist in real-time identification of anatomy during cholecystectomy (gallbladder removal).
 We propose to define the effectiveness of NIRF-C in identifying the cystic duct junction
 during cholecystectomy.
This study is designed to determine the clinical utility of intravenous indocyanine green
 (ICG) injection pre-operatively for cholecystectomy, followed by visualizuation of the
 biliary tree with a near-infrared light source and camera. Testing will be done during an
 abdominal surgery which requires gallbladder removal. Subjects will be recruited during
 consult for their surgical procedure. The study itself will take an estimated 5 minutes
 during the procedure. 2.5mg of ICG will be injected intravenously 60-30 minutes before
 surgery, and following perfusion of the biliary tree, images will be recorded and visibility
 of the appropriate anatomy will be assessed using a near-infrared light source and camera. If
 fluorescence has faded prior to adequate visualization, a repeat dose of 2.5mg IV ICG may be
 given. Following the completion of imaging, the standard procedure for cholecystectomy will
 be performed including intraoperative cholangiography (IOC), which is standard of care.
 Subject post-operative recovery will be monitored for the duration of their hospital stay.
 Adverse events will be monitored at the patient's routine follow up visit.
Inclusion Criteria:

 -  Age 18-89

 -  Planned laparoscopic cholecystectomy

 Exclusion Criteria:

 -  Inability to provide informed consent

 -  Pregnant

 -  Allergy to ICG, iodine, and/or shellfish

 -  Acute cholecystitis, cholangitis, and/or cirrhosis (main study)

 -  Lactating