PET Imaging of Brain Amyloid in Normal Pressure Hydrocephalus
PET Imaging of Brain Amyloid in Normal Pressure Hydrocephalus
This study will determine the level of association between the quantitative estimates of
 brain uptake of [18F]flutemetamol and the quantitative immunohistochemical estimates of
 amyloid levels in biopsy samples previously obtained during shunt placement in patients who
 have normal pressure hydrocephalus (NPH).
Inclusion Criteria:

 -  The subject is 50 years old or older.

 -  The subject has had a frontal lobe cortical biopsy adequate for the detection and
 quantitation of amyloid.

 -  Informed consent has been signed and dated by the subject/and/or subjects' legally
 acceptable representative, if applicable, in accordance with local regulations.

 Exclusion Criteria:

 -  The subject has a contraindication for MRI or PET.

 -  The subject has a known or suspected hypersensitivity/allergy to [18F]flutemetamol.

 -  The subject has participated in any clinical study using an investigational agent
 within 30 days of dosing.