Effectiveness and Safety of Salba on Weight Loss in Overweight Individuals With Type 2 Diabetes
Effectiveness and Safety of Salba on Weight Loss in Overweight Individuals With Type 2 Diabetes
Canadian statistics indicate that the incidence of obesity is increasing and that the
 occurrence of diabetes in obese individuals is 5-fold greater than those with a healthy
 weight, making weight control in this population particularly relevant. Preliminary clinical
 data has shown that the whole grain, Salba, may improve type 2 diabetes control, reduce
 after-meal blood glucose, cardiovascular disease (CVD) risk factors and suppress appetite.
 Its use may therefore have potential implications in long-term weight management, while
 improving diabetes.

 The objective of this research (weight loss) is to evaluate whether adding Salba to an energy
 reduced diet for six months will result in greater weight loss compared to control in
 overweight and obese individuals with type 2 diabetes. The study recruited 77 overweight or
 obese individuals with type 2 diabetes. They were instructed to follow a calorie restricted
 diet and their regular diabetes therapy together with regular exercise. Participants were
 randomly assigned to receive 30 g Salba/1000 kcal of daily energy requirements, or an oat
 bran control supplement matched for energy. The effect of the supplements on weight-loss
 (including waist circumference, % body fat) and glucose control (A1c, fasting glucose levels)
 will be assessed. In addition, related outcomes such as low-grade body inflammation,
 hunger-regulating hormones (ghrelin, adiponectin), safety measures (urea, creatinine, ALT and
 prothrombin time) and satiety scores were evaluated.

 Modest weight loss has been associated with improved glucose control in individuals with type
 2 diabetes. Addition of Salba to an energy reduced diet may facilitate greater weight loss
 and improve glycemic control and CVD risk factors compared to such a diet alone. Salba may
 also promote maintenance of weight loss and therefore help prevent weight gain by providing
 feelings of fullness that reduce appetite. In light of the high incidence of obesity in
 individuals with diabetes, Salba grain may be a useful addition to the diet.
Inclusion Criteria:

 -  Well-controlled type 2 diabetes for at least 1 year

 -  Treated with diet and/or oral hypoglycemic medications

 -  BMI 25-40 kg/m2

 Exclusion Criteria:

 -  Weight change in the past three months >10% of body weight

 -  On insulin therapy

 -  Unstable angina, myocardial infarction or stroke (within 6 months)

 -  Planned surgery or pregnancy

 -  Blood pressure >160mmHg/100mmHg

 -  Surgical procedures for weight loss and concomitant use of medication or supplements
 that alter body weight or appetite

 -  ALA, dietary fibre, fish oil supplements or consuming cold-water fish more than three
 times per week