A Safety Study of RTA 744 in Patients With Recurrent High-Grade Gliomas
A Safety Study of RTA 744 in Patients With Recurrent High-Grade Gliomas
This study assesses the tolerability, safety, efficacy and pharmacokinetics of RTA 744 in
 recurrent high-grade gliomas.
Malignant gliomas, glioblastoma multiforme and anaplastic astrocytoma, are rapidly growing
 primary brain tumors associated with a high degree of morbidity and mortality. Despite
 aggressive treatment, the median survival rate for GBM is approximately 12 months, with
 two-year survival rates no more than 8 to 12%, while median survival for patients with AA
 ranges from 2 to 3 years from time of first diagnosis.

 RTA 744 is a close chemical analogue of the well characterized anti-cancer agent doxorubicin.
 Unlike doxorubicin, RTA 744 has shown ability to cross the blood brain barrier and to achieve
 high concentration in CNS tumor tissue in animal models. It will be administered by i.v.
 infusions either daily for 3 consecutive days repeated every three weeks, or once weekly for
 4 consecutive weeks repeated every 5 weeks. Once the maximum tolerated dose is determined , a
 new group of patients will be enrolled into the study to evaluate the tolerability and MTD
 when administered on an expanded schedule (once a week).
Inclusion Criteria:

 -  Prior histologically confirmed anaplastic astrocytoma, anaplastic oligodendroglioma,
 anaplastic mixed oligo-astrocytoma, glioblastoma multiforme, or gliosarcoma, for whom
 no other effective therapy is available.

 -  A prior histologic diagnosis of a lower grade of glioma is allowed if there is current
 histologic proof of progression to a diagnosis of AA, AO, AOA, GBM or GS

 -  Unequivocal evidence of recurrence or progression by neuroimaging procedure.

 -  Surgical resection at least 2 weeks prior to enrollment and must have completely
 recovered from the side effects.

 -  A stable dose of steroids for at least 7 days prior to obtaining the Gd-MRI of the
 brain.

 -  Previously implanted Gliadel® wafer may be eligible.

 -  Karnofsky Performance Status (KPS) of ≥ 60.

 -  Laboratory parameters: Absolute Neutrophil Count (ANC) ≥ 1.5 x 109/L, Hemoglobin (Hgb)
 ≥ 9 g/dl, Platelets ≥ 100 x 109/L, AST and ALT ≤ 3.0 x Upper Limit of Normal (ULN),
 Serum bilirubin ≤ 1.5 x ULN, Serum creatinine ≤ 1.5 x ULN and 24 hour creatinine
 clearance ≥ 50 ml/min

 -  Life expectancy of greater than 12 weeks.

 -  Written informed consent obtained.

 Exclusion Criteria:

 -  Pregnancy or breast feeding, or adults of reproductive potential not employing an
 effective method of birth control

 -  Total urinary protein in 24 hours urine collection > 500 mg

 -  Any concurrent severe and/or uncontrolled medical conditions which could compromise
 participation in the study.

 -  Impaired cardiac function, other significant prior cardiac disease or arrhythmia of
 any

 -  A history of CHF or arrhythmias.

 -  Therapeutic doses of warfarin sodium (Coumadin®).

 -  Prior or concurrent therapy, or not recovered from the toxic effects of such therapy:
 investigational drugs, chemotherapy, metronomic daily dosing of chemotherapy agents,
 biologic, immunotherapy or cytostatic agents within 4 weeks prior to study entry;
 radiation therapy within 2 weeks prior to study entry, any medication known to cause
 QT interval prolongation

 -  Any surgery other than resection of a brain tumor within 2 weeks prior to enrollment.

 -  A contraindication to MRI imaging.