Study to Evaluate the Effects of ONO-2952 on Pain Perception Produced by Rectal Distention in Female Subjects With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D)
Study to Evaluate the Effects of ONO-2952 on Pain Perception Produced by Rectal Distention in Female Subjects With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D)
The objective is to evaluate whether ONO-2952 modulates visceral pain perception produced by
 rectal distention in female patients with IBS-D
Inclusion Criteria:

 1. Female 18-65 years of age (inclusive)

 2. Diagnosed with IBS based on the following criteria (Rome III criteria):

 -  Symptom onset at least 6 months prior to diagnosis, and

 -  Recurrent abdominal pain or discomfort at least 3 days per month for the past 3
 months, and

 -  Abdominal discomfort or pain associated with two or more of the following at
 least 25% of the time:

 -  improvement with defecation

 -  onset associated with a change in frequency of stool/defecation

 -  onset associated with a change in form (appearance) of stool

 3. Diagnosed with IBS-D, defined as loose/watery stools ≥ 25% and hard/lumpy stools ≤ 25%
 of defecations

 Exclusion Criteria:

 -  Any structural abnormality of the gastrointestinal (GI) tract (other than esophagitis
 or gastritis)

 -  History of Chron's disease, ulcerative colitis, diabetes mellitus, lactose
 malabsorption, malabsorption syndromes, celiac sprue, or any upper GI symptoms that
 may impact the assessment of IBS symptoms