Molecular Testing to Direct Extent of Initial Thyroid Surgery
Molecular Testing to Direct Extent of Initial Thyroid Surgery
The research study consists of the participant agreeing to 1) the use of preoperative
 molecular testing (ThyroSeq) to guide extent of initial surgery and 2) the prospective
 collection of medical record data related to treatment of thyroid cancer.
The aim of the proposed pilot study is to use a clinical algorithm that incorporates
 molecular, clinical and radiographic factors to inform surgical management. This study is the
 first to propose molecular-directed surgical management for this commonly diagnosed cancer.
Inclusion Criteria:

 -  Thyroid nodule is >1.5 cm

 -  Preoperative FNA biopsy that is positive for papillary thyroid cancer or suspicious
 for papillary thyroid cancer

 Exclusion Criteria:

 -  Prior thyroid/parathyroid surgery

 -  Clinical indications for total thyroidectomy including hypothyroidism, history of head
 or neck radiation when <18 years old

 -  Recurrent laryngeal nerve dysfunction

 -  Diagnosis of concurrent primary hyperparathyroidism