The Effects of Standard Protocol With or Without Colchicine in Covid-19 Infection
The Effects of Standard Protocol With or Without Colchicine in Covid-19 Infection
Based on data regarding the effect of colchicine on the modulation of immune system and
 decreasing cytokine release and inflammation the question arises whether colchicine,
 administered in a relatively low dose, could potentially have an effect on COVID-19
 Polymerase chain reaction(PCR) positive patients .
80 Patients with positive nasopharyngeal swab PCR for COVID-19 which were not hypoxic but
 showed computed tomography involvement compatible with COVID-19 admitted in ward (not in
 Intensive care unit) included and randomized in to two groups. All patients received standard
 treatment protocol including essential minerals, vitamins as antioxidants, antibiotics and
 Kaletra while in one randomly assigned group colchicine would be added.
Inclusion Criteria:

 -  Patients >18 years old with nasopharyngeal swab confirmed COVID-19 PCR, CT involvement
 compatible with COVID, Fever and Dyspnea without hypoxemia.

 Exclusion Criteria:

 -  Patient who is not willing to enter in study

 -  Known hypersensitivity to colchicine

 -  Hepatic failure

 -  Renal failure with eGFR<20 ml/min