The Utility of Serum Tryptase in the Diagnosis of Shrimp- Induced Anaphylaxis
The Utility of Serum Tryptase in the Diagnosis of Shrimp- Induced Anaphylaxis
The purpose of this study was to investigate the utility of serum tryptase for the
 confirmation of shrimp-induced anaphylaxis.
The diagnosis of anaphylaxis is based primarily on the clinical history. In some
 circumstances, inability to confirm the clinical diagnosis such as present with unusual
 manifestation, or when skin signs are absent likely contributes to underrecognition and
 undertreatment of the disease.

 Currently, products of mast cell activation (histamine and total tryptase) can be measure in
 clinical laboratories as markers of acute anaphylaxis events, however these tests have
 clinically relevant limitations.

 Therefore, development of laboratory tests with improved sensitivity and specificity that
 will support the clinical diagnosis of anaphylaxis are needed.

 In addition, shrimp is the major cause of seafood anaphylaxis among Thai children.
Inclusion Criteria:

 -  a history of shrimp allergy

 Exclusion Criteria:

 -  severe anaphylactic reaction from seafood

 -  pregnancy

 -  underlying diseases such as cardiovascular, hepatobiliary, and renal diseases

 -  on systemic corticosteroid or β-blocking agents