A Comparison Of Study Drug Blood Levels After One Dose Of GSK189075 In Subjects With Normal And Reduced Kidney Function
A Comparison Of Study Drug Blood Levels After One Dose Of GSK189075 In Subjects With Normal And Reduced Kidney Function
This is an open-label study that will measure blood levels of different parts of a drug
 called GKS189075. People participating in this study will receive a single dose of 250mg
 GSK189075 by mouth. About 20 people with mild to moderate decrease in renal (kidney) function
 will be asked to participate in this study. They will be compared to about 20 healthy
 participants who are close to the same age and body size. People participating in this study
 will stay at a clinical research unit beginning 2 days before they receive their single dose
 of GSK189075 and will remain there until approximately one day after receiving the study
 drug. During this study urine will be collected beginning the day before receiving study drug
 until the day after, just prior to leaving the clinical research unit. Blood samples will
 also be collected at various times beginning immediately before until 24 hours after
 receiving the study drug.
Inclusion Criteria:

 -  A female is eligible to enter and participate in this study if she is of
 Non-child-bearing potential with a negative pregnancy test at screening or of
 Childbearing potential, has a negative serum pregnancy test at screening, is not
 lactating, and agrees to adequate contraception.

 -  Satisfactory medical evaluation based upon medical history, medication history,
 physical examination, and clinical laboratory data obtained at the Screening visit.

 -  Body weight > 50 kg. BMI within the range of 19 to 40 kg/m2.

 -  Signed and dated written informed consent prior to participation in any
 protocol-specific procedures, including screening procedures.

 -  The subject is able to understand and comply with protocol requirements, instructions,
 and protocol-stated restrictions.

 -  Additional Inclusion Criteria for Subjects with Renal Insufficiency: Subjects with
 renal insufficiency must be considered by the investigator to be clinically stable.
 Subjects must continue to meet this criterion of stable renal function upon check-in
 into the clinic

 Exclusion Criteria:

 -  History of regular alcohol consumption averaging >7 drinks per week for women or >14
 drinks per week for men within 6 months of Screening. One drink is equivalent to 12 g
 alcohol = 5 ounces (oz; 150 ml) of wine or 12 oz (360 ml) of beer or 1.5 oz (45 ml) of
 80 proof distilled spirits.

 -  A positive drug or alcohol test at Screening or Check-in.

 -  Smokers will be allowed to enrol in the study; however, smoking that interferes with
 the collection/recording of ongoing study procedures will not be allowed. Smoking
 status will be recorded in the CRF.

 -  The subject has participated in a clinical trial and has received a drug or a new
 chemical entity within 30 days or 5 half-lives, or twice the duration of the
 biological effect of any drug (whichever is longer) prior to the first dose of study
 medication for the current study.

 -  The subject has donated more than 450mL blood within the 56 day period prior to the
 first scheduled administration of GSK189075.

 -  Known or suspected gastroparesis, gastric surgery within the 6 months prior to
 screening, or any other gastrointestinal condition that would likely interfere with
 absorption of GSK189075.

 -  Subjects with clinical laboratory values outside rages as specified in the protocols

 -  Any subject with either documented cirrhosis or a history consistent with a diagnosis
 of cirrhosis.

 -  Urinary tract or bladder infection within 4 weeks of the first scheduled
 administration of study drug.

 -  Positive hepatitis B surface antigen, or HIV at Screening. If negative test results
 have been documented within the last 2 months, it will not be necessary to repeat
 these tests. Subjects with positive results for hepatitis C antibodies may be eligible
 if they have normal liver enzymes and no history of hepatitis and are approved by the
 GSK medical monitor.

 -  Any history of myocardial infarction, cardiac syncope.

 -  A history of clinically significant cardiac arrhythmias (individual cases to be
 discussed with the GSK Medical Monitor).

 -  A history of unstable angina in the past 6 months.

 -  Cardiac conduction abnormalities denoted by ranges specified in the protocol

 -  Systolic blood pressure < 80 mmHg or > 180 mmHg

 -  Diastolic blood pressure < 60 mmHg or > 100 mmHg

 -  Use of prescription or non-prescription drugs (including high dose vitamins, herbal
 and dietary supplements [including St. John's Wort]) within 7 days prior to
 administration of the first dose of study medication, unless in the opinion of the
 investigator and Sponsor the medication will not interfere with the study procedures
 or compromise subject safety. Some allowable exceptions are found in the Permitted
 Medications section (Section 9.1).

 Additional Exclusion Criteria for Subjects with Renal Insufficiency

 -  Patients on a new drug regimen (defined as starting a new drug or changing dosage
 regimen of a current drug within 7 days prior to administration of GSK189075). No
 restrictions will be placed on the use of insulin, 1,25 dihydroxyvitamin D3
 (Rocaltrol), erythropoietin, and calcium- or aluminum-containing phosphate binders.

 -  Subjects whose current medication therapy is not in agreement with the information
 provided in Sections 9.1, 9.2, or 9.3 of this protocol.

 -  Serum albumin less than 2.5 g/dL.

 -  Hemoglobin less than 8.5 g/dL. Additional Exclusion Criteria for Subjects with Normal
 Renal Function

 -  Any clinically relevant abnormality identified on the screening physical or laboratory
 examination. Any abnormalities of outside the normal reference range at Screening may
 be repeated once and must be reviewed with the GSK Medical Monitor prior to enrollment
 of a subject into the study.

 -  Hemoglobin or hematocrit below the reference range at Screening