Prospective Study of the Evaluation of Disease contRol and the Quality of Life of Patients With depressiOn and With or Without aNxiety disOrders in the Greek populatIon
Prospective Study of the Evaluation of Disease contRol and the Quality of Life of Patients With depressiOn and With or Without aNxiety disOrders in the Greek populatIon
Depression is a psychiatric disorder that affects mood, thoughts and is usually accompanied
 by physical annoyances. It affects the person's eating habits, his sleep, the way he sees
 himself and the way he thinks and understands. Depressed emotion has great tension, lasts
 longer and leads to a reduction in the person's functioning in many areas of his life.

 Generalized Anxiety Disorder (GAD) is the psychiatric disorder characterized by a multitude
 of diverse organic responses as well as a generalized, persistent and indeterminate anxiety
 that covers almost all of the individual's activities. It is a diffuse and intense negative
 mood and anxiety that is present for most of the day and whose exact causes are often
 undetectable.
The Hamilton Depression Scale is the most widely used scale for measuring the severity of
 depression worldwide. It was designed to measure the severity of depression in already
 diagnosed patients with major depressive disorder. It includes 17 entries rated from 0 to 2
 or from 0 to 4, thus giving a total score ranging from 0-50.

 The scores are scored through the symptoms reported by the patient during the interview, the
 evaluator's observations and the information collected from third parties (relatives,
 nurses). The markings do not distinguish between the intensity and frequency of the symptoms,
 but these two should be equally at the discretion of the assessor. The scale covers the
 condition of the patient in the week preceding the mark for most symptoms, except for sleep
 disorders related to the last three days.Health-related quality of life is calculated using
 weighted questionnaires focusing on the general health level of the individual or the impact
 of specific diseases on the quality of life of the patient.

 These questionnaires are based on a common theoretical background, according to which the
 measurement of biological functionality is a basic, but not sufficient, assessment of health.
 Apart from the good functioning of organic systems, which represents the traditional
 biomedical model of health, the need for an assessment of the general well-being and
 functioning of the individual in all areas of his life is also important.

 The EQ-5D questionnaire is a self-completed tool for measuring the quality of life and
 consists of two parts:

 The first part records the person's health profile. Five dimensions are used, referring to
 (a) mobility, (b) self-handling, (c) routine activities, (d) pain-discomfort and (e)
 stress-depression. Each of these dimensions takes three values: 1 = no problem, 2 = some
 problems, 3 = significant problems. Altogether, three health situations are recorded,
 representing 243 cases. The best mental state is described as "11111", meaning that there is
 no problem in terms of mobility, self-care, routine activities, pain and anxiety. The worst
 mental health status gets the "33333" values, which means significant problems in the above
 five dimensions.

 The second part presents a visual analogue scale (VAS) in the form of a "health thermometer",
 which takes values from 0 = worse mental health to 100 = excellent mental health.
 Intermediate values of the optical proportional scale indicate intermediate health status.
 This scale is based on the person's subjective assessments of his / her state of health.

 Using the EQ-5D, it is possible to estimate the benefit enjoyed by the individual from
 different health situations.

 The HAM-A scale was one of the first assessment scales developed to measure the severity of
 anxiety symptoms and is still used up to now in both clinical and research environments.

 The scale consists of 14 elements, which are determined by a series of symptoms, and measures
 both mental (mental stimulation and psychological discomfort as well as physical anxiety
 (physical anxiety disorders).

 Each question is scored on a scale of 0 (none) to 4 (very serious), with a total score of 0
 to 56. A score of less than 17 indicates mild severity, 18-24 mild to moderate severity and
 25-30 mild to severe.
Inclusion Criteria:

 -  Signed informed consent form

 -  Male or female asthma patients over 18 years of age

 -  Compliance with treatment

 -  Compliance with study procedures

 -  Patients already receiving or to receive citalopram

 -  Patients not adequately controlled by citalopram

 -  Patients not adequately controlled by citalopram and at the same time having a
 generalized anxiety disorder

 -  Patients not regulated at all

 Exclusion Criteria:

 -  Unsigned patient consent

 -  Male or female asthma patients under 18 years of age

 -  Non-compliance with treatment

 -  Non-compliance in study procedures

 -  Patients who do not meet the Product SmPC criteria

 -  Patients receiving MAO inhibitors