Transient Elastography in the Determination of Advanced Fibrosis in Alcoholic Liver Disease.
Transient Elastography in the Determination of Advanced Fibrosis in Alcoholic Liver Disease.
Alcoholic liver disease is the most frequent complication of excessive alcohol consumption.
 Early diagnosis of alcoholic liver disease is essential to avoid its complications that could
 be fatal. To date, the reference diagnostic tool is an invasive procedure: the liver biopsy.
 The transient elastography is a useful tool for early diagnosis of liver fibrosis. This tool
 is validated in the diagnosis of liver fibrosis due to C chronic hepatitis. Because it is
 non-invasive, fast, given immediate results; transient elastography could be repeated in
 alcoholic patients for liver fibrosis follow-up. In the present study, the investigators
 propose to realize liver biopsy and transient elastography in 300 alcoholic patients in
 weaning to evaluate the transient elastography accuracy in the exclusion of sever liver
 fibrosis (Metavir 3 and 4). The reference liver fibrosis diagnosis tool will be the liver
 biopsy.
Inclusion Criteria:

 -  Patients more than 18 years old; hospitalised for alcoholic weaning; with an alcoholic
 liver disease; with at risk alcoholic consumption; with an indication of liver biopsy;
 with a signed consentment.

 Exclusion Criteria:

 -  patients with a cirrhosis; with other causes of liver disease; with a contraindication
 of liver biopsy; having had a liver biopsy in the last 3 years; pregnancy; major
 benefiting from a legal protective measure; no coverage care.