Effect of Muscular Exercise on Cough Reflex
Effect of Muscular Exercise on Cough Reflex
The hypothesis is that the cough reflex induced by capsaicin is inhibited during exercise.
 The purpose of this study is to determine if a short muscular exercise inhibits the cough
 reflex induced by capsaicin inhalation.
Cough is an important reflex of defense of airways. It is also one of the more frequent
 symptoms during respiratory diseases. Chronic cough can be a disabling condition, apparently
 idiopathic or associated to pathology such as asthma, sinusitis with posterior discharge or
 gastroesophageal reflux.

 Factors susceptible to provoke or increase cough are well known, but inhibiting factors are
 much less known. Muscular exercise is thought to influence respiratory reflexes in a
 considerable and complicated way. For example, a bronchodilation is observed in healthy or
 asthmatic individuals, but recovery period frequently triggers asthma attacks. Effects of
 exercise on cough reflex are much less known.

 This study aims to determine the influence of muscular exercise on cough reflex in children
 and healthy adults.

 Highlighting the inhibition of cough reflex by exercise can have a significant effect on
 chronic cough patient care. There is actually no symptomatic treatment really effective
 without side effects.
Inclusion Criteria:

 -  Obtaining of informed consent (or informed consent of parents or persons with parental
 authority)

 -  Affiliation to social security

 -  Negative answer to all 12 questions of medical questionnaire for child or to all 11
 questions of medical questionnaire for adult

 -  Normal cardio-respiratory examination

 -  Normal electrocardiogram

 -  Without spirometry obstructive syndrome (FEV1 > 70% of predicted value and FEV1/FVC
 >70%)

 Exclusion Criteria:

 -  Refusal or impossibility of obtaining informed consent of person or of persons with
 parental authority)