The Role of Mucosal Microbiome in the Development, Clearance and Recurrence of Clostridioides Difficile Infection
The Role of Mucosal Microbiome in the Development, Clearance and Recurrence of Clostridioides Difficile Infection
The study is being done to identify types of bacteria associated with the lining of the large
 intestine in people who have recently been diagnosed with C. difficile infection to determine
 if there are features associated with development, clearance, and recurrence of disease.
Patients who were recently diagnosed with C. difficile infection will undergo assessment of
 both before treatment and after completing treatment to study the presence of C. difficile in
 the colonic mucosa pre as well as assessment for microbiome and patient/clinical factors that
 may contribute to disease recurrence. Assessment will include sigmoid colon biopsies, blood
 draw, stool samples and surveys.
Inclusion Criteria:

 -  Adults aged 18 and over

 -  Confirmed C. difficile infection based on positive C. difficile toxin PCR testing and
 clinical evidence of diarrhea

 Exclusion Criteria:

 -  Known active pregnancy

 -  Prior diagnosis of C. difficile infection within 2 months of this diagnosis

 -  Other known active gastrointestinal infectious process

 -  Vulnerable adults

 -  Any other disease(s), condition(s) or habit(s) that would interfere with completion of
 study, or in the judgment of the investigator would potentially interfere with
 compliance to this study or would adversely affect study outcomes