Positive Expiratory Pressure During Inhalation of Hypertonic Saline in Patients With Cystic Fibrosis
Positive Expiratory Pressure During Inhalation of Hypertonic Saline in Patients With Cystic Fibrosis
This trial aims to analyze whether the inhalation of hypertonic saline combined with a
 positive expiratory pressure (PEP) device increases the amount of sputum expectorated during
 the chest physiotherapy session ( inhalation + bronchial drainage).
All patients will perform two different arms of treatment in a crossover randomization. Each
 arm of treatment will be applied during 5 consecutive days. The wash-out period will be one
 week. Before starting the trial all patients will do an inhalation formation.

 During the study period the patients' pharmacological treatment remains unchanged
Inclusion Criteria:

 -  Pass the inhalation test

 -  Chronic sputum production, at least ≥ 10 ml /24h

 -  Cystic Fibrosis (CF) diagnosed ( established by genotype or sweat sodium>70 mmol/l or
 sweat chloride of>60 mmol/l)

 -  Clinically stable at the time of recruitment (defined as no requirement for
 antibiotics or change in respiratory medication in the preceding 4 weeks)

 -  Trained in the use of autogenic drainage technique (at least 6 months)

 -  Inhaling hypertonic saline since at least 6 months

 -  To be able to provide written, informed consent and perform the protocol and the
 evaluations

 Exclusion Criteria:

 -  Active massive hemoptysis during the previous 2 months

 -  Patient in transplantation or retransplantation list

 -  Patient already participating in another study at the same time