Involvement of Viral Infections in the Pathogenesis of Chronic Lymphocytic Thyroiditis
Involvement of Viral Infections in the Pathogenesis of Chronic Lymphocytic Thyroiditis
Autoimmune diseases represent a heterogeneous group of pathologies whose etiopathogenic
 mechanisms are most often unknown. Autoimmune diseases are the leading cause of morbidity and
 mortality in young women and autoimmune thyroid diseases are the most common.

 Viral infections are the main environmental factors suspected of triggering autoimmune
 diseases. Several viruses are certainly involved, all of which are possibly capable of
 triggering an autoimmune response. However, the precise identification of the viruses
 involved remains to be established.

 It has been shown for the first time by the 2005 PHRC that enteroviral RNA is present in
 perioperative specimens of thyroid tissue. However, this case-control study did not show any
 difference between the thyroid group and the group other thyroid pathologies It has been
 recently published that Parvovirus is possibly involved in thyroiditis: the parvoviral genome
 is present in the thyroid tissue of Hashimoto thyroiditis operated and more precisely is
 present within the thyrocytes itself.
Inclusion Criteria:

 -  Patients participating in PHRC 2005 "involvement of enteroviruses in TLC pathogenesis"

 -  Inclusion of TLC: presence of a significant lymphocyte infiltrate within the thyroid
 parenchyma defined by the presence of clusters of more than 30 to 50 lymphocytes

 -  Inclusion of controls: absence of significant lymphocyte infiltrate

 Exclusion Criteria:

 -  Persons refusing to participate in research