Study of Insulin Resistance and Endometrial Cancer in Harris County, Texas
Study of Insulin Resistance and Endometrial Cancer in Harris County, Texas
The goal of this clinical research study is to find out if there is a link between insulin
 resistance (or pre-diabetes) and endometrial cancer.

 Primary Objective:

 1. To determine the association between insulin resistance and endometrial cancer in women in
 Harris County, Texas. 2. To assess the effect of body mass index (BMI) on the association
 between insulin resistance and endometrial cancer.

 Secondary Objectives:

 1. To explore the association between polycystic ovarian syndrome (PCOS) and endometrial
 cancer.

 2. To assess the relationship between known reproductive risk factors, menstrual risk
 factors, family history and endometrial cancer.

 3. To explore the molecular changes associated with insulin resistance and PCOS on normal
 endometrium and tumor tissue.
This study will be comparing women who have had endometrial cancer (cases) to women who have
 not had endometrial cancer (controls) in Harris County, Texas to better understand the risk
 factors for getting endometrial cancer. Insulin resistance is a condition of pre-diabetes.
 Polycystic ovarian syndrome (PCOS) is a condition associated with irregular periods, obesity,
 infertility, and/or difficulty in getting pregnant. Both insulin resistance and PCOS are
 believed to increase a woman's risk of getting endometrial cancer.

 As part of this study, you will be asked to fill out a questionnaire that asks about your
 medical history, weight history, family history, reproductive history, and birth
 control/hormone use. The questionnaire should take about 20 minutes to complete, and you will
 need to complete it only once. You will have your height and weight measured, and about 4
 teaspoons of blood will be drawn to test for insulin resistance (or pre-diabetes). You will
 be required to fast, not eat or drink anything except water, for 8 hours before having this
 blood sample drawn. If you are premenopausal and still have both your ovaries, you will have
 an additional 4 teaspoons of blood drawn to test for PCOS. You will complete the
 questionnaire during your first visit or at home and will bring it back with you when you
 come back for your fasting blood test appointment.

 If you have been diagnosed with endometrial cancer and have had surgery to remove your
 uterus, you will also be asked to give permission to use a piece of your leftover tumor and
 surrounding normal tissue to test for markers of insulin resistance and PCOS. This will be
 from tissue that was removed during your surgery and will not require another biopsy or
 surgery.

 You will not be required to come back for any follow-up as part of this study. However, you
 will be asked to fill out a form that asks if you would be willing to be called in the future
 to participate in other studies.

 This is an investigational study. A total of 700 women will take part in this multicenter
 study, 350 women with endometrial cancer and 350 women without endometrial cancer. A total of
 up to 350 women will be enrolled at M.D. Anderson.
Inclusion Criteria:

 1. Women with histologically confirmed primary endometrial cancer, who will consent to be
 enrolled in the study no later than 12 weeks after their primary treatment. All
 stages, grades and histologic subtypes will be eligible.

 2. Women who reside in Harris County, Texas. (Cases)

 3. Patients must sign an informed consent for the study. (Cases)

 4. Women must speak and understand English or Spanish. (Cases)

 5. Women who reside in Harris County, Texas. (Controls)

 6. No history of prior malignancy with the exception of non-melanoma skin cancer.
 (Controls)

 7. Intact uterus. (Controls)

 8. Patients must sign an informed consent for the study. (Controls)

 9. Women must speak and understand English or Spanish. (Controls)

 Exclusion Criteria:

 1. Women who reside outside of Harris County, Texas. (Cases)

 2. Patients unwilling or unable to provide informed consent. (Cases)

 3. Metastatic cancer to the endometrium from a different primary. (Cases)

 4. Women who do not speak and understand English or Spanish. (Cases)

 5. Women who reside outside of Harris County, Texas. (Controls)

 6. Previous hysterectomy. (Controls)

 7. History of prior malignancy with the exception of non-melanoma skin cancer. (Controls)

 8. Patients unwilling or unable to provide informed consent. (Controls)

 9. Women who do not speak and understand English or Spanish. (Controls)