To Determine the Role of Prokinetics in Feed Intolerance in Critically Ill Cirrhosis
To Determine the Role of Prokinetics in Feed Intolerance in Critically Ill Cirrhosis
1. All patients with chronic liver disease admitted in ICU (Intensive Care Unit) to be
 screened.

 2. Patients fulfilling criteria for feed intolerance to be included in the study.

 3. Patients to undergo routine biochemical and hematological testing including CBC, KFT,
 LFT, PT/INR, electrolytes baseline and daily along with ABG (Arterial Blood gas)
 analysis.

 4. Patients with ascites to be tested for presence or absence of SBP (Spontaneous Bacterial
 Peritonitis).

 5. Cultures to be sent as based on clinical parameter of the patient.

 6. All correctable causes for intra abdominal hypertension to be corrected including
 electrolyte imbalance, grade III ascites, intra abdominal infection.

 7. Symptoms- Absent bowel sounds (BS)= no BS detected by auscultation.
 Vomiting/regurgitation= any visible regurgitation of gastric contents; Diarrhoea= liquid
 stool > or =3 times/day; Bowel distension= suspected clinically and radiologically
 confirmed; Large gastric residual volume (GRV) of >or =500 ml/24 h on a single day or >
 200ml at any time of the day.

 8. Per abdomen findings to be checked daily including presence of bowel sounds, tenderness,
 development of abdominal distension, abdominal girth monitoring and abdominal pressure
 monitoring.

 9. Patients who develop feed intolerance will be included.

 10. Feed intolerance to be defined as per study definition (3 out of 5 symptoms).

 11. Measurement of GRV (Gastric residual volume) to be done at 4 hourly interval.

 12. Methods for measuring GRV by either gravity drainage by connecting a gastric tube to a
 drainage bag for 10min or by manual aspiration of content using a 50ml syringe.

 13. Once feed intolerance develop than every 6 hourly intra abdominal pressure monitoring
 and abdominal girth monitoring to be done (24)

 14. Intra bladder pressure to be measured using Foleys manometer technique (25).

 15. Pressure measured in cm of water to be converted into mm of Hg.

 16. X ray abdomen supine to look for bowel distension, defined as more than 3 cm for small
 bowel and more than 5 cm in large bowel.

 17. Development of intra abdominal hypertension based on intra abdominal pressure.

 18. Patient to be stratified according to the grade of intra-abdominal hypertension.

 19. After correction of all correctable causes, if feed intolerance persists, then patient
 to be randomized by block randomization method into 3 arms, metaclopromide group,
 erythromycin group or placebo group.

 20. Daily assessment of bowel sounds, abdominal pressure, abdominal girth every 6 hourly and
 gastric residual volume to be noted every 4 hourly.

 21. Response of therapy to be assessed at 24 hours in each arm.

 22. Response to be assessed by resolution of feed intolerance or initiation of entral
 nutrition.

 23. Metoclopromide to be given 10mg iv 8 hourly.

 24. Erythromycin to be given 70mg iv 12 hourly (26).

 25. Placebo arm to receive normal saline in 10ml syring twice daily.

 26. After 24 hours of treatment if symptoms do not resolve than rescue treatment will be
 given to each arm which may include continuation of prokinetics, add on prokinetic,
 flatus tube insertion for bowel decompression, upgradation of antibiotics or search for
 any other cause, as per the patient response.

 27. Therapy to continue for a total duration of 72 hours.

 28. If there is no response at 72 hours, than study stops.

 29. If patient responds to given treatment, study to continue for a total duration of 7
 days.

 30. Assessment to continue in each arm for a maximum period of 7 days.
Inclusion Criteria:

 1. Patients who develop new onset feed intolerance to enteral nutrition

 Exclusion Criteria:

 1. Any patient with current or past surgical abdomen including mechanical obstruction,
 mesenteric ischemia, perforation or requiring abdominal surgery.

 2. Patients receiving enteral nutrition through gastrostomy or jejunostomy.

 3. Patients in whom, prokinetics are contraindicated or are allergic to the same.

 4. Patients who received prokinetic more than one day prior to the start of enteral
 feeding.

 5. Patients with uncontrolled sepsis with DIC.

 6. Requirement of two or more vasopressors.

 7. Organ failure requiring high inotropic support.

 8. Advanced cardiopulmonary disease, with prior history of arrhythmias, structural heart
 disease.

 9. History of traumatic brain injury, raised intracranial pressure, history of myasthenia
 gravis.

 10. Endocronolgic illnesses: Hypothyroidism, hypoparathyroidism

 11. Connective tissue diseases (systemic sclerosis, dermatomyositis or polymyositis,
 systemic lupus erythematosis, amyloidosis).

 12. Known case of diabetes with diabetic gastroparesis

 13. Pregnancy

 14. Patients or concerned family member who fail to give consent for study enrollment

 15. Age less than 18 years and more than 70 years.