OVEMP in Myasthenia
OVEMP in Myasthenia
Myasthenia gravis is an autoimmune disorder of neuromuscular transmission, characterized by
 fluctuating muscle weakness and fatigability. In isolated ocular myasthenia, when only the
 extraocular muscles are involved, most common ancillary tests, such as acetylcholine receptor
 autoantibodies and repetitive nerve stimulation, are often negative.

 A simple, quick and non-invasive test for ocular myasthenia based on ocular vestibular evoked
 myogenic potentials (oVEMP) was recently developed.

 The main goal of the study is to validate repetitive oVEMP stimulation in a blinded
 diagnostic accuracy study in order to facilitate early and accurate diagnosis of ocular
 myasthenia.
Inclusion Criteria:

 -  Informed Consent as documented by signature

 -  Patients with diplopia and/or ptosis suspicious for myasthenia gravis.

 Exclusion Criteria:

 -  Vestibular disorders

 -  Significant systemic myasthenia symptoms (respiration or swallowing difficulties)
 unable to undergo oVEMP testing.

 -  Patients with significant cardiac or respiratory disease will be excluded from the
 Tensilon test as part of the reference standard.

 -  Women who are pregnant or breast feeding.