An Evaluation of Clotting Factor Activity Before and After Total Hip Arthroplasty
An Evaluation of Clotting Factor Activity Before and After Total Hip Arthroplasty
The objective of the study was to analyze both the concentration and the activity of the
 clotting factors, D-dimer levels, as well as fibrinogen concentration in patients who
 underwent primary total hip arthroplasty due to idiopathic arthrosis.

 Blood loss is often related to perioperative period and may result in decrease of
 concentration of coagulation factors, which in turn may lead to increased bleeding. We
 analyzed data of thirty patients scheduled for primary hip arthroplasty: the activity of
 clotting factors II, VIII, X, as well as fibrinogen concentration in the following time
 points: (i) before surgery, (ii) six hours after the procedure, and (iii) two, (iv) four, and
 (v) six days after the operation. All laboratory tests were performed using automatic
 analyzer. At the same time intervals, an immunoenzymatic assay was used to determine D-dimer
 levels.
Inclusion Criteria:

 -  patients qualified for primary hip arthroplasty for idiopathic osteoarthritis

 Exclusion Criteria:

 -  hip osteoarthritis because of non-idiopathic etiology

 -  history of venous thromboembolism or arterial embolism

 -  anticoagulation treatment,

 -  coagulopathy

 -  infection, and

 -  renal failure defined as a creatinine clearance below 50 ml/minute.