Effectiveness of Diclofenac and Its Association to Codeine After Lower Third Molar Extraction.
Effectiveness of Diclofenac and Its Association to Codeine After Lower Third Molar Extraction.
It will be evaluated the clinical efficacy of Diclofenac 50mg (NSAID) compared to its
 association with Codeine 50mg (opioid) administered in 50 patients requiring extraction of
 two third molars. After assessing the research parameters, a comparative data analysis, along
 with the proper application of statistical tests, will provide the basis for an evaluation of
 both efficiency medications used.
This research will evaluate the clinical efficacy of Diclofenac 50mg (NSAID) compared to its
 association with Codeine 50mg (opioid) administered in 50 patients aged less than 18 and
 requiring extraction of two third molars (with very similar positions, whose degree of
 difficulty is high). It will be assessed the following parameters: 1) onset and duration of
 surgery after administration of local anesthetic, 2) open mouth prior to surgery, on the 2nd
 day after the operation and on the 7th day after surgery (removal points), 3) subjective
 assessment of pain using a visual analog scale, 4) measurement of facial edema in the second
 day after the operation and on the 7th day after surgery (as compared with the measurements
 obtained before surgery) and 5) the incidence, type and severity of adverse reactions. The
 analysis comparative data, along with the proper application of statistical tests, provide
 the basis for an evaluation of both efficiency medications used.
Inclusion Criteria:

 -  Impacted lower third molar

 -  not in use of NSAID or opioids in the last one month

 Exclusion Criteria:

 -  Local anesthetics allergy,

 -  History of gastrointestinal bleeding or ulcers,

 -  Kidney disease,

 -  Asthma,

 -  Allergy or sensitivity to aspirin or any other NSAID or opioids,

 -  Pregnant or nursing woman,

 -  Patients using antidepressant, diuretic or aspirin,

 -  Patients under treatment to quit drugs