Clonidine Versus Phenobarbital as Adjunctive Therapy for Neonatal Abstinence Syndrome
Clonidine Versus Phenobarbital as Adjunctive Therapy for Neonatal Abstinence Syndrome
The purpose of this study is to compare clonidine versus phenobarbital as adjunctive therapy
 in those infants who have failed monotherapy with morphine sulfate for neonatal abstinence
 syndrome (NAS).
Inclusion Criteria:

 -  Infants greater than or equal to 35 weeks gestation age

 -  Admitted to the neonatal intensive care unit

 -  Failed monotherapy with morphine sulfate therapy

 Exclusion Criteria:

 -  Neonatal abstinence syndrome due to iatrogenic causes

 -  Unable to take oral medications at any point during their treatment

 -  Infants in the custody of the Department of Child Protective Services with no legal
 guardian identified at the time of enrollment