Evaluate Safety and Efficacy of Rifamycin SV MMX in the Treatment of Traveler's Diarrhea in Children Age 6 to 11 Years
Evaluate Safety and Efficacy of Rifamycin SV MMX in the Treatment of Traveler's Diarrhea in Children Age 6 to 11 Years
This will be a double-blind comparative study, performed in pediatric subjects (Age 6-11)
 traveling to developing regions with a known high incidence of traveler's diarrhea. The
 subjects will be suffering from acute diarrhea for at least 12 hours, without symptoms of
 systemic infection.
Approximately 142 subjects are expected to be enrolled in the study, 1:1 in the Rifamycin SV
 MultiMatrix (MMX) plus Oral Rescue Therapy (ORT) group and in the placebo tablets plus ORT
 group respectively. The day of randomization (Visit 1, Day 1), the subjects will start the
 treatment receiving ORT plus Rifamycin SV MMX 100 mg (as two tablets of 50 mg each) twice
 daily (morning and evening) or ORT plus placebo tablets (as two tablets) twice daily (morning
 and evening). The subjects will begin the treatment within 72 hours of onset of diarrhea.
 Treatment duration will last 72 hours. The total number of tablets for the entire treatment
 course will be 12 (4 × 50 mg tablets/day for 3 days). The administration of the ORT will
 follow the specification reported in the product label. The tablets will be orally
 administered during the day. No tablet administration will be done during the night.

 After enrollment, subjects/their parents/or guardians will complete Diary cards (PDC) in
 which will be daily recorded date, time of first tablets intake, time and consistency of each
 stool, presence of blood in stools, abdominal pain/cramps, flatulence, tenesmus, urgency,
 nausea, vomiting, fever, adverse events (AEs), and concomitant medications.

 During the study, the subjects will be assessed for safety and efficacy at Visit 2 (Day 2)
 and Visit 3 (Day 4/5) as final Study Visit.

 Stool samples for microbiological assessment will be collected at Visits 1 and 3. Stool will
 be examined and cultured at local labs for main enteropathogens and for the presence of
 protozoa, ova and yeasts.

 Blood and urine sampling for routine safety analyses will be collected at Visit 1 and at
 Visit 3.
Inclusion Criteria:

 -  Diagnosis of acute bacterial diarrhea defined as at least 3 unformed stools within the
 24 hours preceding randomization, with a duration of illness ≤72 h. The bacterial
 origin of diarrhea will be confirmed "a posteriori" by stool microbiology sampling at
 the time of screening.

 -  Presence of one or more signs or symptoms of enteric infection, including nausea,
 vomiting, abdominal cramps or pain, tenesmus, urgency

 -  History of recent travel from an industrialized country to a developing region with a
 known high incidence of travelers' diarrhea

 -  Male or female 6-11 years of age, providing an unformed pre-treatment stool

 -  The parent or legally acceptable representative must provide informed consent for the
 subject. The Subject must also provide written informed assent and be accompanied by
 the parent or legal guardian at the time of assent/consent signing.

 Exclusion Criteria:

 -  Fever (>100.4ºF or 38ºC), or presence of signs and symptoms of systemic infection

 -  Known or suspected infection with non-bacterial pathogen

 -  Symptoms of acute diarrhea of >72 hours duration

 -  Presence of grossly bloody stool

 -  Moderate to severe dehydration

 -  History of inflammatory bowel disease (IBD)

 -  Abdominal ileus

 -  Severe dehydration

 -  Greater than two doses of an antidiarrheal medication within 24 hours before
 randomization, or any symptomatic therapy within 2 hours before enrolment

 -  Receiving antimicrobial drug with expected activity against enteric bacterial
 pathogens within the week prior to enrolment

 -  Hypersensitivity to rifamycin-related antibiotics or to any excipient included in the
 study medications

 -  Subjects unable/unwilling to comply with study protocol

 -  Participation in a clinical trial within the last 30 days