A Randomized, Double-Blinded Study of Simvastatin 20 mg/Day Versus Vytorin 10/20 in Subjects With Lipid Profiles Not Meeting Current NCEP Guidelines, Following a Low-Carbohydrate Diet
A Randomized, Double-Blinded Study of Simvastatin 20 mg/Day Versus Vytorin 10/20 in Subjects With Lipid Profiles Not Meeting Current NCEP Guidelines, Following a Low-Carbohydrate Diet
People who follow a low-carbohydrate diet typically experience a decrease in triglycerides
 and increase in HDL-C level, but fail to lower their LDL cholesterol (LDL-C). Such patients
 may require lipid-lowering therapy. Statins may not be the most effective strategy for
 patients on this diet, since they typically consume a greater amount of saturated fat and
 cholesterol. Absorbed cholesterol may contribute more to their circulating plasma LDL-C. We
 hypothesize that patients following a low carbohydrate diet would experience a significantly
 greater decrease in LDL-C by taking ezetimibe 10 mg, a drug that blocks cholesterol uptake in
 the intestine, in addition to simvastatin 20 mg, when compared to taking simvastatin 20 mg
 alone.
Inclusion Criteria:

 -  Moderately obese with hyperlipidemia

 Exclusion Criteria:

 -  Recent unstable heart or lung condition

 -  Current use of other lipid modifying drugs

 -  Hepatic disease

 -  Pregnancy or lactation