Medium Chain Triglycerides Plasma Profile and Their Metabolites After Oral Peptamen Intake
Medium Chain Triglycerides Plasma Profile and Their Metabolites After Oral Peptamen Intake
Medium Chain Triglycerides (MCT) have been used for many years as a good source of lipid to
 decrease potential for fat malabsorption. However, the pharmacokinetics of MCT and of their
 metabolites have not been explored in details.

 This is an exploratory study aiming at determining the plasma level of MCT and their
 metabolites after oral intake of Peptamen.
20 subjects will be given 250mL of peptamen 1.5 twice, with 4 hours of interval, on a single
 day.

 Plasma kinetics of MCTs and their metabolites will be made over 8 hours from baseline
Inclusion Criteria:

 -  Healthy males and females

 -  Aged between 20 and 65 years old

 -  BMI in the normal range (18.5 to 25.0 kg/m2)

 -  Having signed his/her consent form

 Exclusion Criteria:

 -  Clinically relevant digestive (including malabsorption or major surgery), renal,
 hepatic, pancreatic or metabolic disease (diabetes, hypo or hyperthyroidism, hypo or
 hypercorticism), as determined by the medical (screening) visit and a standard blood
 chemistry analysis (glucose, total cholesterol, ALDL, AHDL, triglycerides, ASAT, ALTI,
 gamma GT, RCRP, creatinine)

 -  Medically diagnosed anemia based on a blood formula

 -  Food allergy, lactose intolerance and intolerance to milk proteins (anamnesis)

 -  Smokers (anamnesis)

 -  Pregnancy (anamnesis)

 -  Under corticoids or hormone (adrenal, thyroid) treatment

 -  Alcohol intake: > 2 units a day (anamnesis)

 -  Consumption of illicit drugs (anamnesis)

 -  Having given blood within the last month, or willing to make a blood donation until
 one month following the end of the study

 -  Subject who cannot be expected to comply with the study procedures, including
 consuming the test product

 -  Currently participating or having participated in another clinical trial during the
 last month prior to the beginning of this study.