BIOmarkers of TRAumatic Brain Injury Spain (BIOTRABIS)
BIOmarkers of TRAumatic Brain Injury Spain (BIOTRABIS)
Traumatic brain injury (TBI) is defined as a structural alteration of brain function caused
 by external causes, where mild traumatic brain injury (mTBI) represents approximately 80% of
 all TBI, and although its prognosis is relatively good, it represents a significant cost to
 the system due to the need to perform a cranial computed tomography (CT) scan, a test of high
 economic value and not without risks such as irradiation, especially important and dangerous
 in the pediatric age.

 The investigators aim to set-up a point of-care (POC) device to validate a biomarker (H-FABP)
 able to diagnose the presence of brain damage in children and adults with mTBI at trauma and
 paediatric Emergency Departments using a blood sample, in order to save resources and avoid
 subjecting patients to a potentially damaging imaging test. But also, to assess whether the
 incorporation of new biomarkers improves the prediction of brain damage that can be done with
 H-FABP.

 For that, the investigators will recruit a 400 patients' cohort with blood samples using the
 available POC device for H-FABP biomarker.
BIOTRABIS>18 (adult patients)

 Inclusion Criteria:

 -  Patients over 18 years old

 -  Mild TBI patients the first 24 hours after trauma with GCS of 14-15 points.

 -  Presence of any of the following symptoms:

 -  Loss of consciousness less than 30 minutes, the first 20 minutes after trauma

 -  Post-traumatic amnesia less than 24 hours, the first 30 minutes after trauma:

 -  Persistent headache

 -  Nausea / vomiting

 -  Vertigo / dizziness

 -  Confusion / disorientation

 Exclusion Criteria:

 -  Dementia or other pre-existing neurological condition that makes evaluation difficult

 -  Recent history (<1 month) of TBI

 -  Refusal to participate in the study

 -  Evidence of alcohol or other substance intoxication

 -  Previous stroke

 -  Previous severe TBI

 -  Epilepsy

 -  Schizophrenia

 -  Neurodegenerative disease

 BIOTRABIS<18 (paediatric patients)

 Inclusion Criteria:

 -  Patients between 0 and 17 years old.

 -  Mild TBI (GCS 14-15) and moderate TBI (GCS 9-13) patients the first 24 hours after
 trauma.

 -  Presence of any of the following symptoms:

 -  Loss of consciousness less than 30 minutes, the first 20 minutes after trauma

 -  Post-traumatic amnesia less than 24 hours, the first 30 minutes after trauma:

 -  Persistent headache

 -  Nausea / vomiting

 -  Vertigo / dizziness

 -  Confusion / disorientation

 Exclusion Criteria:

 -  Dementia or other pre-existing neurological condition that makes evaluation difficult

 -  Recent history (<1 month) of TBI

 -  Refusal to participate in the study

 -  Evidence of alcohol or other substance intoxication

 -  Previous stroke

 -  Previous severe TBI

 -  Epilepsy

 -  Schizophrenia

 -  Neurodegenerative disease