Biomarkers for Therapy Response in Drug-resistant Tuberculosis
Biomarkers for Therapy Response in Drug-resistant Tuberculosis
Multi-center, observational, prospective cohort study including patients with
 multidrug-resistant tuberculosis at different sites in Germany.

 The aim the study is the identification of biomarkers for therapy response.
The increasing rates of multidrug-resistant (MDR) tuberculosis (TB) are causing great
 concern. The current study that will be conducted at different centers in Germany. Biomarkers
 for treatment response during the course of the tuberculosis therapy will be evaluated. The
 study will be conducted with funding of the German Center for Infection Research (DZIF).
Inclusion Criteria:

 -  Subjects with confirmed pulmonary MDR-TB

 -  Subject able and willing to give informed consent

 Exclusion Criteria:

 -  HIV infection

 -  physical or mental inability preventing study participation at the discretion of the
 investigator

 -  member of a vulnerable or special population (prisoner, soldier, mentally ill, under
 guardianship)

 -  age <18 years.