BNCT to Treat Glioma That Has Progressed Following Radiotherapy
BNCT to Treat Glioma That Has Progressed Following Radiotherapy
Boron Neutron Capture Therapy (BNCT) is an experimental radiation therapy technique which is
 based on the principle of irradiating boron atoms with neutrons. When neutrons have
 relatively low energy, boron atoms that have been targeted to cancerous tissue using a
 suitable boron carrier (an amino acid derivative called BPA, boronophenylalanine) will
 capture the neutrons. As a result from the neutron capture the boron atoms will split into
 two, producing helium and lithium ions. The helium and lithium ions, in turn, have only a
 short pathlength in tissue (about 5 micrometers) and will deposit their cell damaging effect
 mainly within the tumor provided that the boron carrier (BPA) has accumulated in the tumor.
 In practice, the study participants will receive BPA as an approximately 2-hour intravenous
 infusion, following which the tumor is irradiated with low energy (epithermal) neutrons
 obtained from a nuclear reactor at the BNCT facility. BNCT requires careful radiation dose
 planning, but neutron irradiation will last approximately only for one hour. In this study
 BNCT is given once. The study hypothesis is that anaplastic astrocytomas and glioblastomas
 that have recurred following conventional radiotherapy might accumulate the boron carrier
 compound, and might respond to BNCT.
This is a single BNCT-facility, non-randomized, non-comparative, prospective, open-label,
 phase I/II study to determine the value of BNCT in the treatment of inoperable, irradiated,
 progressing anaplastic astrocytomas or glioblastomas following conventional radiation
 therapy. The neutron irradiation site is the FiR 1 reactor site, located at Otaniemi, Espoo,
 Finland, about 6 kilometers from the Helsinki University Central Hospital, Helsinki, where
 patient evaluation and post-irradiation care will take place.

 BPA is infused as a fructose complex (BPA-F) into a peripheral vein over 2 hours prior to
 neutron irradiation. Blood samples will be taken before starting the BPA infusion, and
 thereafter at 20 to 40 minute intervals during the infusion, following infusion, and after
 delivering neutron irradiation to monitor the blood boron concentration. The blood samples
 will be analyzed for boron to estimate the average blood boron level during neutron
 irradiation. A minimum tumor dose of 17 Gy (W) is given while limiting the normal brain
 maximum peak dose to 8 Gy (W), and the average normal brain dose to 6 Gy (W). The first 10
 patients will be given BPA 290 mg/kg, following which the BPA dose will be escalated in
 cohorts of 3 subjects gradually up to 450 mg/kg, provided that protocol-specified
 unacceptable toxicity will not occur.

 All patients will be evaluated for response using CT or magnetic resonance imaging (MRI).
Inclusion Criteria:

 -  Histologically confirmed supratentorial glioblastoma or anaplastic astrocytoma.

 -  Recurred tumor after surgery and radiotherapy or tumor progressing after radiotherapy.

 -  Recurrence/progression has been confirmed by serial MRI scans and a biopsy, or by
 debulking surgery.

 -  The World Health Organization performance status <2.

 -  WBC >2,500/mm3, platelet count >75,000/mm3, serum creatinine <180 umol/L.

 -  A written informed consent

 Exclusion Criteria:

 -  Age less than 18

 -  Tumor infiltrates into the brain stem or the optic tracts

 -  The majority of tumor tissue consists of grade II glioma with only a focal grade III
 component

 -  A minimum gross tumor dose of 17 Gy (W) is not obtained in dose-planning

 -  Less than 6 months has elapsed from the last date of external irradiation

 -  Less than 4 weeks has elapsed from the last cancer chemotherapy dose prior to giving
 BNCT

 -  The total conventional radiation therapy dose given is more than 61 Gy or less than 50
 Gy, or one of nonconventional fractionation schemes has been used (conventional:
 1.8-2.0 Gy/day, 5 days per week, weekly dose 9 to 10 Gy)

 -  More than approximately 1/3 of the total brain volume has been within the 90% isodose

 -  Gliomas where the enhancing tumor volume is larger than 2/3 of the volume of one
 hemisphere in the MRI examination preceding BNCT

 -  More than one radiotherapy course has been given to the brain tumor

 -  Untreated congestive heart failure or renal failure

 -  Uncontrolled brain oedema despite the use of corticosteroids

 -  A cardiac pace-maker or an unremovable metal implant present in the head and neck
 region that will interfere with MRI-based dose-planning

 -  Restlessness or inability to lie in a cast for 30 to 60 minutes

 -  Clinical follow-up after therapy cannot be arranged

 -  Pregnancy

 -  Inability to understand treatment options

 -  Unwillingness to take part in the follow-up schedule