Sunitinib in Treating Patients With Kidney Cancer That Cannot Be Removed by Surgery
Sunitinib in Treating Patients With Kidney Cancer That Cannot Be Removed by Surgery
RATIONALE: Sunitinib may stop the growth of kidney cancer by blocking blood flow to the tumor
 and by blocking some of the enzymes needed for cell growth.

 PURPOSE: This phase II trial is studying the side effects and how well sunitinib works in
 treating patients with kidney cancer that cannot be removed by surgery.
OBJECTIVES:

 -  To determine the percentage of patients with renal cell carcinoma and unresectable
 primary tumors who can achieve sufficient tumor response, according to the operating
 surgeon, to undergo nephrectomy after sunitinib therapy.

 -  To evaluate the safety of sunitinib in patients with renal cell carcinoma and
 unresectable primary tumors, including analysis of the morbidity of surgery after
 sunitinib therapy

 -  To evaluate the objective response rate of patients with renal cell carcinoma and
 unresectable primary tumors who receive sunitinib therapy.

 OUTLINE: A single arm phase II study of sunitinib in patients with unresectable renal cell
 carcinoma (RCC) will be conducted, including patients with and without distant metastases.

 Patients receive oral sunitinib malate once daily on days 1-28. Treatment repeats every 42
 days in the absence of disease progression or unacceptable toxicity. Surgery is performed if
 and when primary tumor becomes resectable. Patients with residual and/or metastatic disease
 may resume sunitinib malate within 8 weeks after surgery.

 After completion of study treatment, patients are followed periodically.

 PROJECTED ACCRUAL: A total of 31 patients will be accrued for this study.
Inclusion Criteria:

 -  Histologically or cytologically confirmed renal cell carcinoma (any histology) based
 on prior biopsy or biopsy performed and reviewed at Cleveland Clinic Foundation. This
 can include pathology read as adenocarcinoma consistent with renal origin.

 -  Unresectable primary tumor due to any of the following factors or various combinations
 thereof:

 -  Large tumor size (> 15 cm)

 -  Bulky lymphadenopathy (> 4 cm or encasement of renal vessels or great vessels)

 -  Venous thrombosis (high level/invasive disease requiring inferior vena cava
 reconstruction or hypothermic circulatory arrest)

 -  Proximity to vital structures (e.g., mesenteric vasculature)

 -  Any one of these factors may or may not constitute unresectability, but for
 consideration for this trial, the surgical and medical oncologist must agree that
 the particular constellation of findings for the patient under consideration
 would likely entail a low probability (<50%) that the tumor would be resectable
 (with negative margins) or that the potential morbidity associated with an
 attempt at surgical resection would not be clinically acceptable. The numerical
 thresholds noted above are only a guideline and the clinical judgment of the
 surgeon and medical oncologist will determine unresectability.

 -  Patients with history of brain metastases can be enrolled 2 weeks following the
 completion of gamma knife or whole brain radiotherapy.

 -  ECOG performance status (PS) 0-1 or Karnofsky PS >/=70%

 -  Serum aspartate transaminase (AST; serum glutamic oxaloacetic transaminase [SGOT]) and
 serum alanine transaminase (ALT; serum glutamic pyruvic transaminase [SGPT]) ≤ 2.5
 times upper limit of normal (ULN)

 -  Total Serum Bilirubin ≤ 1.5 times ULN

 -  Absolute neutrophil count ≥ 1,500/mm³

 -  Platelet count ≥ 100,000/mm³

 -  Hemoglobin ≥ 8.0 g/dL (transfusion allowed)

 -  Serum calcium ≤ 12.0 mg/dL

 -  Creatinine ≤ 2.5 mg/dL

 -  Signed and dated informed consent document indicating that the patient (or legally
 acceptable representative) has been informed of all pertinent aspects of the trial
 prior to enrollment

 -  Willingness and ability to comply with scheduled visits, treatment plans, laboratory
 tests, and other study procedures.

 Exclusion Criteria:

 -  The presence of any of the following will exclude a patient from study enrollment:

 -  Prior systemic treatment for RCC.

 -  Evidence of bleeding diathesis or coagulopathy. Patients with hematuria from the
 primary renal tumor are eligible provided all other eligibility criteria are met.

 -  Any of the following within the 6 months prior to study drug administration:
 myocardial infarction, severe/unstable angina, severe peripheral vascular disease
 (claudication) or procedure on peripheral vasculature, coronary/peripheral artery
 bypass graft, New York Heart Association grade II or greater congestive heart failure,
 cerebrovascular accident or transient ischemic attack, clinically significant bleeding
 or pulmonary embolism.

 -  Hypertension that cannot be controlled by medications to < 160/90 mmHg.

 -  Known human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome
 (AIDS)-related illness.

 -  Pregnancy or breastfeeding.

 -  Other severe acute or chronic medical or psychiatric conditions or laboratory
 abnormality that may increase the risk associated with study participation or study
 drug administration, or may interfere with the interpretation of study results, and in
 the judgment of the investigator would make the patient inappropriate for entry into
 this study.