CoHOrt of Cerebral CavernOus maLformATion: multicEnter Prospective Observational Study
CoHOrt of Cerebral CavernOus maLformATion: multicEnter Prospective Observational Study
The aim of this prospective study is to reveal the natural history of symptomatic hemorrhage
 in adult patients with cerebral cavernous malformation with the goal of informing the
 treatment plan.
Cerebral cavernous malformation Patients with newly diagnosed, cerebral cavernous
 malformation who will visit one of the study centers during the period from June 2016 to
 December 2017. Patients would be eligible for enrollment if they were 18 years of age or
 older and had at least 1 cerebral cavernous malformation. If the patient had multiple
 cavernous malformations, index cavernous malformation would be enrolled. Index lesion will be
 determined according to the criteria.

 -  Index lesion decision criteria I. Symptomatic II. Asymptomatic (priorities are as
 follows)

 1. Previous bleed

 2. Brain stem location

 3. Deep nuclei (thalamus, caudate, basal ggl, hypothalamus)

 4. Periventricular

 5. Largest

 All patients who would visit a study center during the enrollment period and meet these
 criteria will be asked to join the study. The cohort will consists of patients who agree to
 participate. Target population of this study is 228 patients.
Inclusion Criteria:

 -  Patients with newly diagnosed cerebral cavernous malformation who agreed to
 participate.

 -  18 years old or more

 Exclusion Criteria:

 -  Patients who underwent treatment(surgery or radiosurgery) for cavernous malformation

 -  Patients who are accompanied by other serious medical problems