Intensification Therapy of Mature B-ALL, Burkitt and Burkitt Like and Other High Grade Non-Hodgkin's Lymphoma in Adults
Intensification Therapy of Mature B-ALL, Burkitt and Burkitt Like and Other High Grade Non-Hodgkin's Lymphoma in Adults
All patients are treated according to the same therapy regimen. Therapy duration (number of
 cycles) and radiotherapy vary according to age group, stage and response. Chemotherapy
 consists of a pre-phase-treatment (for all patients) and varying A, B and C cycles. Therapy
 for Patients in the 18-55 Age Group

 -  Patients in stages III-IV and all patients with mediastinal tumors or extranodal
 involvement are administered 6 cycles (A1, B1, A2, B2, A3, B3).

 -  Chemotherapy is stopped after 4 cycles (A1, B1, A2, B2) for patients with stage I/ II if
 a clear CR has been achieved and there is initially no mediastinal or extranodal
 involvement.

 -  In cases of refractory or progressive disease after 4 cycles, study therapy is stopped.
 These patients are to be given salvage therapy with subsequent stem cell
 transplantation. Therapy for Patients older than 55 years

 -  The course corresponds to that of patients in the younger age group, but the regimen is
 dose reduced (A1*, B1*,A2*, B2*, A3*, B3*). Antibody therapy with anti-CD20 is to be
 administered on day 1 of each chemotherapy cycle (A, B). After end of chemotherapy (6 or
 4 cycles) 2 more cycles of anti-CD 20 are to be administered to reach a total number of
 8 resp. 6 cycles antibody therapy.
Inclusion Criteria:

 -  Acute lymphoblastic leukemia of the mature B-cell type (L3-ALL)

 -  High-grade non-Hodgkin's lymphoma of the following subtypes (WHO classification)

 -  Burkitt's lymphoma (including atypical Burkitt's lymphoma)

 -  Precursor B-lymphoblastic lymphoma

 -  Anaplastic large-cell lymphoma (Ki1+, B-, T- oder Null-cell-type)

 -  Mediastinal large B-cell-lymphoma (subtype of diffuse large B-cell lymphoma)

 -  Age = 18 years

 -  Patient's Informed Consent

 Exclusion Criteria:

 -  Serious complications caused by leukemia/ lymphoma or by a second illness: e.g.

 -  Severe, unmanageable complications such as sepsis, pneumonia with oxygen
 deficiency,

 -  Shock, hemorrhage at the time of diagnosis

 -  Renal insufficiency from leukemia/lymphoma-unrelated causes

 -  Severe cardiac or hepatic insufficiency

 -  Severe obstructive or restrictive lung disease that would compromise patient's
 treatment with intensified chemotherapy

 -  HIV infection

 -  Secondary lymphoma following prior chemotherapy/ radiotherapy or an active second
 malignancy

 -  Known severe allergy to foreign proteins

 -  Cytostatic pretreatment for B-ALL/lymphoma (exceptions: short-term administration of
 steroids = 7 days, single administration of vincristine or cyclophosphamide, one cycle
 of CHOP, a single administration in an emergency of other cytostatic agents) for
 another malignant disease within the last 5 years

 -  Pregnancy/ nursing period

 -  Severe psychiatric illness or other circumstances giving ground to the assumption that
 a patient cannot give his consent to therapy or act co-operatively

 -  Absence of patient's informed consent

 -  Participation in another clinical study that would possibly interfere with study
 therapy