Designer Dialysis Peritoneal Dialysis
Designer Dialysis Peritoneal Dialysis
This study aims to use modified peritoneal dialysis prescriptions to achieve adequate
 clearance and volume removal while decreasing the number of exchanges or time spent on
 dialysis, evaluating maintenance of residual renal function, and improving quality of life.
Patient's currently on peritoneal dialysis at our program can be considered for this study.
 In order to be enrolled, patients patient's must have significant residual renal function
 defined as a renal Kt/V >1.0. These patients will then be consented, and if agreeable, the
 participant's dialysis prescriptions will be modified to decrease their peritoneal dialysis.
 For patients on continuous ambulatory peritoneal dialysis (CAPD), this may mean less
 exchanges in a 24 hour period, or less exchanges over the course of the week (does not need
 to perform exchanges every day). Patients who are continuous cycler peritoneal dialysis
 (CCPD) will be modified to shorter cycler times, or also less cycles during the course of the
 week (does not need cycler therapy every day).

 Patients will need to continue achieving adequate weekly total Kt/V of greater than or equal
 to 1.7 as per national recommendations and the clinical guidelines within our unit. This is
 calculated using the residual renal (RR) Kt/v and the PD Kt/V. Patients will also perform
 monthly 24 hour urine collections for urinary volume, creatinine clearance, and urea
 clearance. Adequacy is typically measured every 3 months based on our internal lab
 requirements, but patients will need to perform adequacy measurements any time their
 prescription is changed. The investigators will measure monthly labs per routine including
 albumin, parathyroid hormone (PTH), serum phosphorus, and hemoglobin.

 The investigators hypothesize that patients will have a better quality of life (QoL) while on
 a modified dialysis prescription with less exchanges or less cycler time as assessed by the
 kidney disease quality of life (KDQOL-36) survey tool. The investigators believe that
 patients with higher levels of residual renal function (≥ 2 mL/min) can perform fewer
 peritoneal dialysis exchanges while still achieving and maintaining adequate clearance of
 solute and appropriate volume removal. The investigators also believe that by maximizing the
 use of the residual renal function, the investigators can adjust the peritoneal dialysis
 prescription by decreasing the numbers of manual exchanges per day, decreasing cycler time,
 or possibly decreasing the number of days of dialysis each week. With the benefit of less
 dialysis time or exchanges per day, the investigators believe patients will have a decreased
 "burnout" rate by allowing them to have a better QoL and not feel burdened by the dialysis
 therapy.
Inclusion Criteria:

 -  patients on either CAPD or CCPD and had both residual renal (RR) Kt/V ≥ 1.0 and total
 Kt/V values ≥ 1.7.

 Exclusion Criteria:

 -  patients who did not meet the values of RR Kt/V and total Kt/V specified above