Clinical Trial on Treatment of Intraventricular Hemorrhage
Clinical Trial on Treatment of Intraventricular Hemorrhage
The specific objective of this trial is to determine the lowest dose and dose frequency
 possible with the best pharmacokinetic and safety profile and it's ability to remove a blood
 clot from the ventricular system.
The purpose of this trial is to determine the efficacy and pharmacokinetics of
 intraventricular injections of multiple low doses of rt-PA. Sixteen subjects were already
 randomized to receive intraventricular injections of with 0.3 mg or 1.0 mg of rt-PA every 12
 hours for up to 8 doses. Results of this stage (n=16) were then analyzed and the most
 effective dose of 1.0 mg was chosen to be used in the second stage (n=36) to determine the
 optimal frequency of dosing. We propose to test if this intervention facilitates more rapid
 clot resolution, complete recovery function and decreased mortality from this condition.
Inclusion Criteria:

 1. Age 18-75

 2. IVC placed as standard of care using less than or equal to 2 complete passes.

 3. Spontaneous ICH less than or equal to 30 cc.

 4. Able to receive first dose within 48 hours of CT scan diagnosing IVH (providing the
 time of symptom onset to diagnostic CT does not exceed 12 hours).

 5. Clot size measured on CT scan done 6 hours after IVC placement must be equal to the
 presentation clot size plus or minus 5 cc (as determined by the AxBxC)/2 method).

 6. ON stability CT scan either the 3rd or 4th ventricles are occluded with blood (no
 evidence of CSF flow on CT).

 7. SBP < 200 mmHg sustained for 6 hours.

 8. Historical Rankin of 0 or 1.

 Exclusion Criteria:

 1. Suspected or untreated aneurysm or AVM (unless ruled out by angiogram or MRA/MRI).

 2. Clotting disorders.

 3. Patients with platelet count < 100,000, INR > 1.7, PT > 15s, or an elevated APTT.

 4. Pregnancy (positive pregnancy test).

 5. Infratentorial hemorrhage (i.e., parenchymal/posterior fossa hematoma; all cerebellar
 hematomas excluded).

 6. SAH (An angiogram should be obtained when the diagnostic CT scan demonstrates
 subarachnoid hemorrhage or any hematoma location or appearance not strongly associated
 with hypertension. If the angiogram does not demonstrate a bleeding source that
 accounts for the hemorrhage, the patient is eligible for the study).

 7. ICH enlargement during the 6-hour stabilization period (6 hour after IVC placement).

 8. Internal bleeding, involving retroperitoneal sites, or the gastrointestinal,
 genitourinary, or respiratory tracts.

 9. Superficial or surface bleeding, observed mainly at vascular puncture and access sites
 (e.g., venous cutdowns, arterial punctures) or site of recent surgical intervention.

 10. Known risk for embolization, including history of left heart thrombus, mitral stenosis
 with atrial fibrillation, acute pericarditis, and subacute bacterial endocarditis.

 11. Prior enrollment in the study.

 12. Any other condition that the investigator believes would pose a significant hazard to
 the subject if the investigational therapy were initiated.

 13. Participation in another simultaneous medical investigation or trial.