The Evaluation of Bepreve on the Measurement of Wheal and Flare Response From Histamine Skin Prick Testing
The Evaluation of Bepreve on the Measurement of Wheal and Flare Response From Histamine Skin Prick Testing
To evaluate the effect of BEPREVE compared to a REFRESH Tears Lubricant eye drop on the
 measurement of the wheal and flare from histamine skin prick testing. This is an open label,
 two-week, post-marketing study conducted on histamine responsive patients.
Inclusion Criteria:

 -  Healthy male and female subjects, 18 to 65 years of age

 -  Patients must demonstrate a positive reaction to a Histamine skin-prick test.
 Manifested by a histamine-induced wheal of >3mm in diameter over the normal saline
 control after 15 minutes of elapsed time

 Exclusion Criteria:

 -  Significant signs and symptoms of currently active allergic disease (SAR, perennial
 allergic rhinitis, episodic allergic rhinitis)

 -  Upper respiratory tract infection, sinusitis, asthma or flu-like symptoms within 2
 weeks prior to visit 1

 -  Subjects who have dermatographism or other skin conditions which might interfere with
 the interpretation of the skin test results

 -  Subjects who are receiving escalating doses of immunotherapy, oral immunotherapy or
 short course (rush) immunotherapy

 -  Known hypersensitivity to the investigational product or to drugs with similar
 chemical properties

 -  Pregnancy and/or breast feeding

 -  Use of antihistamines, NSAIDS, steroids, or other drugs which may affect the
 skin-response

 -  Use of any medications or agents that are not specified above that may confound the
 interpretation of the results