A Dose Ranging Pilot Study for Intracerebroventricular (ICV) Delivery of Valproate in Subjects With Temporal Seizures
A Dose Ranging Pilot Study for Intracerebroventricular (ICV) Delivery of Valproate in Subjects With Temporal Seizures
Patients with medically refractory epilepsy will be treated by intracerebroventricular (ICV)
 delivery of valproate using an implantable drug pump system. The dose of valproate will be
 escalated weekly during a blinded-evaluation period through Day 64 to determine the maximum
 tolerated dose (MTD). After Day 64, patients can continue for 52 weeks in the open-label
 evaluation period (non-blinded). .
Epilepsy patients that are refractory to oral anti-epileptic drug (AED) treatment have
 significantly higher mortality, higher morbidity, higher economic costs and diminished
 quality of life compared to those who suffer from epilepsy that can be adequately controlled
 with medical management. Current options for refractory patients include neurosurgical brain
 resection, responsive neurostimulation, and vagal nerve stimulation. None of these options is
 satisfactory due to the low applicability of surgery for patients with poorly localized or
 multifocal seizures and the limited success of currently available alternative treatment
 options.

 In this study, patients with medically refractory focal epilepsy will be treated with
 intracerebroventricular (ICV) administration of valproate using an implantable drug pump
 system. This is a dose ranging study, with a randomized, double-blind dose escalation
 component, to establish the dose range of ICV valproate delivery. Clinical assessments,
 adverse events (AEs), seizure diaries, concomitant medications, blood samples and
 cerebrospinal fluid (CSF) will be collected and reviewed at designated time points. Magnetic
 resonance imaging (MRI) and electroencephalography (EEG) will also be performed. Subjects
 will have their surgery, dose changes and pharmacokinetics performed in an inpatient setting.

 The ICV Valproate dose will be escalated stepwise from 3 mg/day to 60 mg/day through Day 64
 if tolerated, or stopped earlier upon establishment of a subject's maximum tolerated dose
 (MTD). The MTD for each subject will be determined based on the highest dose tolerated
 without experiencing a dose-limiting adverse event (AE). After establishing a subject's MTD,
 delivery of ICV Valproate will continue at the MTD through Day 64 of the blinded evaluation
 period. Subjects and assessing physicians will remain blinded to the treatment dose during
 the blinded evaluation period. Subjects can continue in the open-label evaluation period
 (non-blinded) for 52 weeks following the blinded evaluation period.
Inclusion Criteria:

 1. Subject is 18 to 65 years old.

 2. Subject does not have coagulopathy, ventricular anatomic distortion or abnormally low
 brain weight or significant volume loss etc. and is approved to have surgery.

 3. Subject had onset of epilepsy after age 5, had normal brain development up to age 5,
 and has full scale IQ > 70 by testing or functional assessment.

 4. Subject has brain volume which is not noted to be abnormally small due to atrophy by
 either the radiologist reading on MRI scan or the treating clinicians (the
 neurosurgeon) review of the MRI scan.

 5. Subject has had confirmed epilepsy for a minimum of 1 year, with diagnosis of focal
 seizures with temporal lobe onset, with or without secondarily generalized seizures,
 as defined by the International League Against Epilepsy (ILAE) Classification of
 Epileptic Seizures (1981).

 6. In the opinion of the investigator, subject has disabling seizures. Disabling refers
 to seizures that are severe enough to cause injuries, or significantly impair
 functional ability in domains including employment, psychosocial education and
 mobility.

 7. Subject has had a CT or MRI of the brain to rule out progressive structural lesions.

 8. Subject has had an EEG or video EEG or invasive monitoring within the past 3 yrs
 consistent with partial seizures (a normal interictal EEG is consistent with partial
 seizures)

 9. Subject has previously failed at least 3 AEDs in single or combination use.

 10. Subject is taking currently approved AED medication(s) (but is not on valproate or
 divalproex sodium) and has been on a stable dosing regimen for 1 month prior to
 Screening.

 11. Subject has completed all investigations necessary to satisfy the PI that noninvasive
 therapies are not likely to be satisfactorily successful.

 12. For the 3 months before informed consent an average of four or more clinically
 significant focal seizures of temporal lobe onset, with or without secondary
 generalization, per month. Only seizures with objectively visible manifestations
 should be counted. The subject should have no period longer than 30 days in the 3
 months prior to enrollment with less than 2 seizures. Seizures of hippocampal origin
 are preferred if the seizure origin is known or determined from imaging and seizure
 localization.

 13. Subject has seizures that are distinct, stereotypical events that can be reliably
 counted, in the opinion of the Investigator, by the subject or caregiver.

 14. Subject has hearing, vision, and physical abilities adequate to perform assessments,
 with or without corrective aids, including keeping a seizure and medication diary
 during study follow-up.

 15. Subject understands study procedures and has voluntarily provided signed, informed
 consent in accordance with institutional and local regulatory requirements.

 16. Medically refractory for more than one year.

 17. Needs be literate in English or native language of the country of the study enrollment
 to complete neuropsychological testing.

 18. Subject can be reasonably expected to maintain a seizure diary alone or with the
 assistance of a competent individual.

 19. Women of childbearing potential must be using a medically accepted method of
 contraception and have a negative qualitative β-human chorionic growth hormone (β-HCG)
 pregnancy test result from a urine or blood sample collected at Screening.

 Non-childbearing potential is defined as any female who is post menopausal since the last 1
 year or has had hysterectomy or bilateral oophorectomy or is surgically sterilized.

 Medically accepted forms of birth control include:

 1. Intrauterine device in place for at least 3 months

 2. Adequate barrier methods (e.g., diaphragm and foam), or an oral contraceptive in
 combination with another method (e.g., spermicidal cream). An oral contraceptive alone
 is not considered adequate for this study.

 If on hepatic inducing AEDs which could lower serum hormone levels (phenytoin,
 phenobarbital, primidone, carbamazepine, oxcarbazepine, topiramate, zonisamide, rufinamide,
 lacosamide) then an oral contraceptive must have minimum dosage equivalent to 50 µg daily
 of ethinyl estradiol.

 Exclusion Criteria:

 1. Subject has any significant neurologic disease other than epilepsy.

 2. Subject has history, within 12 months prior to Screening, of repetitive seizures that
 cannot be counted.

 3. Subject has pseudoseizures or seizures secondary to illicit drug or alcohol use,
 neoplasia, active CNS infection, demyelinating disease, degenerative neurological
 disease, progressive central nervous system disease or metabolic illness.

 4. Subject has been diagnosed with partial motor, primarily generalized seizures or has
 been diagnosed with psychogenic or nonepileptic seizures in the preceding year.

 5. Subject has had status epilepticus refractory to benzodiazepines and phenytoin within
 one year prior to Screening

 6. Subject is currently taking neuroleptic medication for behavior control.

 7. Subject is taking scheduled doses of benzodiazepines or has required, in the 3 months
 prior to Screening, benzodiazepine use more than 4 times per month for seizure
 control. One use is defined as taking up to 3 doses in a 24 hour period.

 8. Subject is currently implanted with an activated DBS, or RNS device used for treatment
 of a neurologic or psychiatric condition.

 9. Subject has VNS and the VNS stimulation parameters are not stable. Stable shall be
 defined such that the stimulation parameters have been changed in the last 4 months or
 the patient/designee is able to report "magnet swipe" during the same time period.

 10. Subject is currently taking oral valproic acid or sodium divalproex.

 11. Subject has refractory motor seizures.

 12. Subject has had more than 10 seizures in one day or more than 300 seizures in one
 month within the last year.

 13. Subject has known allergy to valproic acid, divalproex sodium, Epilim, or Depacon.

 14. Subject has unstable depression being treated with more than 1 anti-depressant
 medication, or has current evidence of or history within the past 2 years of DSM-IV
 criteria for any major psychiatric disorder including psychosis, major depression,
 bipolar disorder, and prior suicide attempt within five years. Also excluded are
 subjects with a history of postictal psychosis or psychosis or depression secondary to
 a discontinued AED.

 15. Subject has had alcohol or substance abuse within the past 5 years.

 16. Subject has uncontrolled Type I or Type II diabetes, hypercoagulability. Controlled
 diabetics for >12 months as evidenced by HbA1C <8% can be included in study based on
 Investigators assessment.

 17. Subject has history or evidence of congestive heart failure, clinically significant
 peripheral edema, or anemia with a hematocrit <30%.

 18. Subject has liver function tests aspartate aminotransferase (AST) or alanine
 aminotransferase (ALT) at Screening ≥ 3 times the upper limit of normal, or clinically
 significant renal disease or insufficiency.

 19. Subject has elevated (clinically significant thrombocytosis) or decreased (< 175/μL)
 platelet count. Subjects should not be taking aspirin or nonsteroidal
 anti-inflammatory drugs within the week before and week after implantation of catheter
 and pump.

 20. Subject has abnormal prothrombin time or INR (> 14 seconds) or partial thromboplastin
 time (> 50 seconds).

 21. Subject has, after 3 minutes in the supine position, systolic blood pressure < 90 or >
 180 or pulse outside the range of 50-100 beats per minute.

 22. Subject has had cancer within 3 years prior to Screening with the exception of
 squamous and basal cell carcinomas of the skin, and in situ carcinoma of the breast or
 cervix.

 23. Subject is on chronic anticoagulants or, in the opinion of the Investigator, is not a
 suitable candidate for cranial surgery for any reason.

 24. Subject has known HIV infection or known or suspected prion disease.

 25. Subject has known allergies to drugs or excipients.

 26. Subject is breastfeeding.

 27. In the opinion of the investigator, the subject has a clinically significant or
 unstable medical condition (including alcohol and/or drug abuse) or a progressive CNS
 disease