Water- and Salt-homeostasis in Healthy Humans, and in Patients With Heart- or Lung Disease
Water- and Salt-homeostasis in Healthy Humans, and in Patients With Heart- or Lung Disease
The purpose of the study is to determine whether the excretion of renal water- and
 salt-channels in the urine reflects the handling of water and salt in the kidneys, and
 whether the excretion can be used to monitor and/or predict the effects of treatment of
 certain heart or lung diseases.
The purpose of the study is to determine whether the excretion of renal water- and
 salt-channels (Aquaporin-2 and Epithelial Sodium Channels) in the urine accurately reflects
 the handling of water and salt in the distal tubules af the kidneys, and whether
 quantification of these channels in the urine is useful to monitor and/or predict the effects
 of pharmacologic or surgical treatment of Heart Failure and heart failure-related diseases
 (Aortic stenosis, acute and chronic ischemic heart disease or pulmonary hypertension)
Inclusion Criteria:

 -  Symptomatic heart failure

 -  Severe valvular aortic stenosis

 -  Acute Coronary Syndrome

 -  Medically refractory chronic angina pectoris or pulmonary hypertension with preserved
 left ventricular function

 Exclusion Criteria:

 -  Pregnancy

 -  Drug abuse

 -  Malignant disease

 -  Significant disease of other organs including endocrine diseases