Prednisone-Placebo vs Prednisone-Valacyclovir in Bell´s Palsy
Prednisone-Placebo vs Prednisone-Valacyclovir in Bell´s Palsy
Since steroids carry a moderate beneficial effect in Bell's palsy, and to address this
 question, valacyclovir was added to prednisone for the treatment of this condition.
Between December 2002 and December 2003, a total of 52 subjects with BP were evaluated, 42
 fulfilled the inclusion criteria and entered the study, 1 patient was lost to follow-up after
 the first visit, leaving a total of 41 patients with complete clinical follow-up.

 To be included in the study, patients had to be evaluated within the first 72 hours and could
 have no contraindications to steroid or valacyclovir therapy.

 Patients were randomly assigned to either the prednisone-valacyclovir (group 1) or the
 prednisone-placebo group (group 2) Among the 41 patients completing the study, 19 pertenecian
 al group 1 and 21 group 2 Both groups received prednisone, a dose of 1 mg/kg body weight was
 given daily for 7 days (one single dose after breakfast). The treatment was tapered over the
 next 14 days. Those taking valacyclovir received 1000 mg in two daily doses for 7 days. All
 subjects were instructed about eye protection and lubrication were followed at regular
 intervals until recovery or for a minimum period of 3 months. Follow-up included examination
 at 1, 2, 4, 8 and 12 weeks after the first visit. Patients with incomplete recovery at 3
 months were controlled until complete recovery or stabilization of the paralysis. All
 subjects were evaluated for laboratories parameters. Routine blood count, blood sugar, and
 liver function tests were performed at first visit.

 There were no severe side effects attributable to the valacyclovir-prednisone treatment in
 this study.

 Informed consent was obtained from all patients. Facial nerve function was assessed using the
 facial grading system (FGS) The scale used provides a quantitative score with three
 components; resting symmetry, symmetry of voluntary movement and synkinesis and a composite
 score was obtained.

 Student's t-test was employed for quantitative….variables. Comparison of treatment results
 between both groups was performed by….means of an analysis of variance (ANOVA) test of two
 ways (therapy and time).

 All statistical tests were considered received the same level of significance (P = 0.05).
Inclusion Criteria:

 -  Patients with Bell´s palsy evaluated within the first 72 hours.

 Exclusion Criteria:

 -  Peptic ulcer

 -  Tuberculosis

 -  Moderate or severe diabetes

 -  Moderate or severe hypertension

 -  Glaucoma

 -  Manifest cardiac disease

 -  Psychosis

 -  Renal or hepatic dysfunction, and

 -  Pregnancy.