Effects of Enteral Supplement Vitamin D Incritically Ill Patients
Effects of Enteral Supplement Vitamin D Incritically Ill Patients
At present, there is no clinical reference data on how much the concentration of calcifediol
 in the blood increases after supplementing with vitamin D for Taiwanese ICU patients. This
 study aims to investigate the effects of enteral supplementation of vitamin D in critically
 ill patients with vitamin D deficiency. The results of the study are expected to provide
 clinical reference data to intensivists to select adequate dosage of vitamin D
 supplementation for their patients with vitamin D deficiency.

 This is a multi-center, randomized clinical trial. ICU patients will receive vitamin D level
 examination. If the subject's blood calcifediol concentration is less than 20 ng / mL, the
 subject will be included in this clinical trial. Patients who are suitable to enteral
 supplement of vitamin D will be randomly divided to group Control (no vitamin D supplement)
 and group Vitamin D (enteral supplement of 569,600 IU vitamin D). The vitamin D level will be
 measures at specific time points.
Vitamin D deficiency patients have longer hospital stays, higher medical expenditures, and
 higher sepsis-related mortality. The preliminary results of 145 ICU patients of the Northern
 Medical Centers in Taiwan in our ongoing multicenter clinical trial showed that the mean
 calcifediol concentration was about 20.9 ng/mL, much lower than the normal value of 30-60
 ng/ml. An Austrian randomized clinical trial has shown that supplementation of high-dose
 vitamin D in critically ill patients with vitamin D deficiency can reduce patient mortality,
 so it is important to treat critically ill patients with vitamin D deficiency. At present,
 there is no clinical reference data on how much the concentration of calcifediol in the blood
 increases after supplementing with vitamin D for Taiwanese ICU patients. This study aims to
 investigate the effects of enteral supplementation of vitamin D in critically ill patients
 with vitamin D deficiency. The results of the study are expected to provide clinical
 reference data to intensivists to select adequate dosage of vitamin D supplementation for
 their patients with vitamin D deficiency.

 This is a multi-center, randomized clinical trial. ICU patients will receive vitamin D level
 examination. If the subject's blood calcifediol concentration is less than 20 ng / mL, the
 subject will be included in this clinical trial. Patients who are suitable to enteral
 supplement of vitamin D will be randomly divided to group Control (no vitamin D supplement)
 and group Vitamin D (enteral supplement of 569,600 IU vitamin D). The vitamin D level will be
 measures at specific time points. The patients' diagnosis, vital signs, laboratory data,
 30-day survival, and 90-day survival will be recorded.
Inclusion Criteria:

 -  patients in intensive care units

 -  blood calcifediol concentration less than 20 ng / mL

 -  suitable for enteral feeding

 -  no ileus, vomit, or diarrhea

 Exclusion Criteria:

 -  younger than 20 years old

 -  receive high dose vitamin D within 4 weeks (> 3000 IU pre day)

 -  hypercalemia ( > 2.6 mmol/L)

 -  body weight < 45 or > 90 kg

 -  admitted to intensive care unit before this admission within 3 months

 -  have diseases as follows: parathyroid disease, rickets, or liver cirrhosis - Child C

 -  diagnosed with renal stone, tuberculosis, or sarcoidosis

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