Prophylaxis of Postoperative Nausea and Vomiting After Cardiac Surgery
Prophylaxis of Postoperative Nausea and Vomiting After Cardiac Surgery
To investigate the role of postoperative nausea and vomiting risk factors assessment after
 cardiac surgery. We designed a randomized controlled study comparing standard care (no risk
 factor assessment and no intervention) with prophylaxis of postoperative nausea and vomiting
 after cardiac surgery in high risk patients. Prophylaxis of postoperative nausea and vomiting
 by betamethasone (4mg) and/or droperidol (0.625mg) immediately after cardiac surgery,
 depending on risk factors (if risk score is over 2) in the intervention arm.
Patients planned to undergo cardiac surgery were screened for inclusion. Inclusion criteria
 are as follow: Non emergent cardiac surgery; Age > 18 years; Affiliation to French Social
 Security; Approval of participation to the study; at the exclusion of: Pregnancy ; Contra
 indication to antiemetics; Chronic usage of antiemetics; and Emergent or complicated surgery.

 Risk factors for postoperative nausea and vomiting were collected and patients were
 randomized by cluster into two arms.

 Control: No prophylaxis whatever risk score is. Postoperative nausea and vomiting risk
 factors were not available for practicians.

 Intervention: Preoperative collection of postoperative nausea and vomiting risk factors
 available for practicians. Prophylaxis if risk score is over 2. Prophylaxis of postoperative
 nausea and vomiting by betamethasone (4mg) and/or droperidol (0.625mg) immediately after
 cardiac surgery, depending on risk factors in the intervention arm.

 All outcomes are assessed at 48 hours of surgery:

 Primary: occurrence of postoperative nausea or vomiting Secondary: number of postoperative
 nausea and vomiting with visual assessment scale (VAS), and antiemetics used for treatment;
 postoperative pain (VAS) with number of analgesics used; postoperative discomfort (VAS).

 Safety data: side effects and QT corrected intervals.
Inclusion Criteria:

 -  Non emergent cardiac surgery

 -  Age > 18 years

 -  Affiliation to French Social Security

 -  Approval of participation to the study

 Exclusion Criteria:

 -  Pregnancy

 -  Contra indication to antiemetics

 -  Chronic usage of antiemetics

 -  Emergent or complicated surgery