Regional Anesthesia for Sickle Cell Crisis Using Ultrasound in The Emergency Department: Phase I
Regional Anesthesia for Sickle Cell Crisis Using Ultrasound in The Emergency Department: Phase I
The hypothesis of this study is:

 Femoral nerve blocks can feasibly be performed on patients with Sickle Cell Disease and
 painful crisis in the Emergency Department.
Phase I: The feasibility cohort will consist of a convenience sample. Dr. Glassberg will wear
 the SCD-FNB pager at all times and will enroll patients whenever logistically possible.

 Participants: ED patients aged >18 who require admission for vasoocclusive pain involving the
 lower extremities. Vasoocclusive pain is defined as acute onset of corporeal pain, not
 controlled by oral analgesics, in a patient with SCD with no other apparent cause.

 Description of Standard Analgesic Practices: All patients enrolled in the study will receive
 standardized care based on ED computer order sets designed by Drs. Shi & Glassberg and other
 members of the Hematology and Emergency departments (appendix E). Based on NIH52 and American
 Pain Society53 guidelines and current clinical evidence, these protocols were established to
 ensure delivery of optimal opiate therapy for patients with VOC pain. Initially, the patient
 will receive IV doses of opiates at the EP's discretion, followed by initiation of morphine
 or hydro-morphone PCA (patient controlled analgesia). PCA will continue when patient is moved
 to the inpatient floor, where care will also be guided by standardized order sets.

 Description of the FNB Intervention: Throughout the FNB procedure, the patient will have
 continuous EKG, NIBP and O2 saturation monitoring. With the patient in the supine position,
 the leg to be blocked will be slightly abducted and externally rotated. The femoral crease
 and the area approximately 3 inches above and below is prepped and draped in usual sterile
 fashion. 1-2 ml of local anesthetic will be injected at the probable site of insertion. A
 sterile ultrasound probe is used to identify the femoral vessels and the femoral nerve, which
 usually lies 1-2 cm lateral to the artery. The femoral nerve sheath is then entered under
 direct visualization. Before injection, the syringe will be gently aspirated with negative
 blood return to ensure that the needle is not intravascular. 20mL of 0.25% bupivicaine will
 then be given, and deposition of anesthetic will be visualized within the nerve sheath.
 Intermittent aspiration and continuous ultrasound visualization during anesthetic delivery
 will ensure that the tip of the needle has not migrated. Injection will also be stopped and
 the needle repositioned if the patient complains of new or worsening pain, as this may
 indicate intraneural injection. If subjects are experiencing pain in both lower extremities,
 both extremities will be blocked; if subjects are experiencing pain in one lower extremity,
 only the affected extremity will be blocked.

 Outcomes: This study is not exploring the efficacy of the intervention, nor is the
 intervention being compared to a control. Phase one is simply to verify that FNB is a
 feasible procedure to be performed in the ER in this population.
Inclusion Criteria:

 -  Age 18 or above

 -  Documented SCD: HbSS, HbSC, HbSβ0Thal, HbSβ+Thal

 -  Rapid onset of acute pain consistent with VOC

 -  Pain in at least one lower extremity

 -  Pain requiring admission to the hospital

 -  Cognitive ability to report pain on a 0-10 NRS

 Exclusion Criteria:

 -  Primary admitting diagnosis other than VOC

 -  Contraindication to femoral nerve block

 -  Pregnant