The Efficacy and Safety of Leflunomide or Azathioprine Therapy in Myasthenia Gravis Patients After Expand Thymectomy
The Efficacy and Safety of Leflunomide or Azathioprine Therapy in Myasthenia Gravis Patients After Expand Thymectomy
This is a randomized controlled clinical study. The investigators screen of eligible
 patients, randomized divide into the following two groups: corticosteroids + azathioprine
 group, corticosteroids + leflunomide group. The investigators treat the enrolled patients,
 estimate efficacy and observed the side effects according to the requirements of program. The
 investigators establish a clinical database for recording patients date and statistical
 analysis. Evaluation of short-term and long-term efficacy of thymectomized myasthenia gravis
 patients in the different group prove that what kind of treatment can improve the cure rate.
 The investigators will evaluate the acute toxicity (gastrointestinal side effects, liver and
 kidney dysfunction) and long-term toxicity (immune dysfunction, gonadal suppression) when the
 investigators apply these therapy in the treatment of different clinical types of myasthenia
 gravis.
Inclusion Criteria:

 1. 12 to 65 years；

 2. Myasthenia gravis:

 1. Patients who are diagnosed as generalized or ocular myasthenia gravis

 2. have experienced extended thymectomy (including thymic hyperplasia and thymoma)，
 no significant complications in 6 months after operation , and does not received
 any immunosuppressants or glucocorticoids treatments.

 3. do not applied in plasmapheresis or immunoglobulins treatment during 3 months .

 4. women of child-bearing period do not have a plan of pregnant for at least 3 year.

 5. Written consent of the patient, after informing

 Exclusion Criteria:

 1. The liver , kidney or glycometabolic function is abnormal

 2. Seriously complications, such as infection or symptom in central nervous system,

 3. The patients who suffering from malignancy or a history of malignancy, a variety of
 sexually transmitted diseases and HIV infection, tuberculosis infection, and other
 condition which need to prohibit the use of immunosuppressive patients.

 4. Be allergic to leflunomide, azathioprine

 5. Pregnant or suckling period woman

 6. Accompanied with mental disorders and have difficult to communication

 7. Experienced myasthenia crisis in 3 months.

 8. suffering from clear cardiopulmonary functional and brain abnormalities

 9. Have a history of refractory hypertension or peptic ulcer .

 10. One of the white blood cells, hemoglobin, and platelet count obvious abnormalities