Birth Cohort Study for Respiratory Infections
Birth Cohort Study for Respiratory Infections
The primary objectives are to evaluate relationship between nasopharyngeal microbial
 colonization and the occurrence of AOM or pneumonia in infants.
Inclusion Criteria:

 -  Age: 18-35 years

 -  Parity: any but with history of previous normal delivery

 -  Weight: Body Mass Index greater than 18.5 but less than 35

 -  Past obstetric history: Uncomplicated pregnancy, unremarkable medical and obstetric
 conditions

 -  Current pregnancy: Uneventful progression of pregnancy

 -  General health: Normal health related functional status during pregnancy

 -  Singleton pregnancy as determined by clinical examination and/or by ultrasonography

 -  Cephalic presentation as determined by abdominal clinical examination

 -  Expected to have normal pregnancy related outcome

 -  Written informed consent

 Exclusion Criteria:

 -  Medical history: Known history of diabetes, hypertension, or any systemic disorder

 -  Gynecological history: History of major gynecological problem/treatment

 -  Complications in previous pregnancy

 -  Previous obstetric cholestasis

 -  Previous acute fatty liver disease

 -  Conditions during current pregnancy

 1. RhD negative mother

 2. APH/Placental abruption

 3. Placenta Praevia

 4. Unstable lie

 5. Multiple pregnancy

 6. Pregnancy induced hypertension (systolic > 140 mm of Hg, diastolic > 90 mm of Hg)

 7. Severe pre-eclampsia or eclampsia

 8. Gestational diabetes

 9. Onstetric cholestasis

 10. Current history of drug/alcohol abuse

 11. BMI of less than 18.5 or more than 35. Severe pallor as detected clinically or by
 HB level (< 7 gm/dL), and oedema

 12. Blood samples drawn and tested for VDRL (Positive VDRL) Cephalopelvic
 disproportion (CPD)

 13. History of taking antibiotic within 3 weeks prior to this study

 14. Patient unwilling to comply with study protocol