Strawberries and Knee Osteoarthritis (OA)
Strawberries and Knee Osteoarthritis (OA)
The proposed study aims to examine the hypothesis that strawberry supplementation will lower
 serum biomarkers of inflammation and improve knee function in patients with symptomatic
 osteoarthritis (OA).
The investigators propose the following two specific aims in a randomized crossover
 placebo-controlled trial in participants with two or more features of the metabolic syndrome
 and symptomatic osteoarthritis in this 12-week efficacy study:

 Aim 1: To assess the effects of strawberries on biomarkers of inflammation [serum levels of
 C-reactive protein: CRP; inflammatory cytokines: interleukin-6: IL-6; interleukin 1β: IL-1β;
 tumor necrosis factor-alpha: TNFα] Aim 2: To assess the effects of strawberries on knee
 function as assessed by overall musculoskeletal examination and pain score (ICOAP, KOOS and
 HAQ-DI).
Inclusion Criteria:

 -  Clinical diagnosis of knee osteoarthritis

 -  Must have waist circumference >35 inches for women and >40 inches for men

 Exclusion Criteria:

 -  Cancer

 -  Heart disease

 -  Smoking

 -  Berry allergy