Genetic Basis of Idiopathic Focal Epilepsies With Cognitif Deficits
Genetic Basis of Idiopathic Focal Epilepsies With Cognitif Deficits
Epilepsy is a frequent neurological disease in childhood, characterized by recurrent seizures
 and sometimes with major effects on social, behavioral and cognitive development. Childhood
 focal epilepsies particularly are age-related diseases mainly occurring during developmental
 critical period. A complex interplay between brain development and maturation processes and
 susceptibility genes may contribute to the development of various childhood epileptic
 syndromes associated with language and cognitive deficits. Indeed, the Landau-Kleffner
 syndrome (LKS), the continuous spike-and-waves during sleep syndrome (CSWS), and the benign
 childhood epilepsy with centrotemporal spikes (BCECTS) or benign rolandic epilepsy, are
 different syndromes that are considered as part of a single continuous spectrum of disorders.
 While genetic component in those three syndromes remains elusive, novel and high throughput
 genome analyzes could bring interesting insights into the possible genetic defects and
 pathophysiological mechanisms underlying and linking the various disorders associating
 epilepsy with speech and cognitive impairments.
Inclusion Criteria:

 -  iodiopathic focal epilepsy with cognitif deficit

 Exclusion Criteria:

 -  medical history of status epilepticus