Effects of Isotretinoin on The Gonads and Hirsutism
Effects of Isotretinoin on The Gonads and Hirsutism
The investigators consider that there are some rising concerns about the use of isotretinoin
 by women of reproductive age with depleted ovarian reserve, hence it is important to detect
 the effect of isotretinoin on ovarian reserve.

 There has not been a well-designed study evaluating its effects on the human ovarian reserve,
 hormone levels and menstrual cycles in women with polycystic ovary syndrome (PCOS). For this
 reasons, this study was administered to determine whether there is an effect of isotretinoin
 on the gonads and hirsutism in women with acne and PCOS.
Inclusion Criteria:

 -  consisted of 40 volunteers women with PCOS (aged 18- 40 years, BMI, 18-44kg/m2) who
 attended our obstetrics and gynecology clinic for the treatment menstrual
 irregularities and hirsutism

 Exclusion Criteria:

 -  1)presence of any dermatologic disorder besides acne 2) presence of any systemic
 disease 3) exposure to any systemic treatment in the last three months that could
 alter ovarian reserve 4) pregnancy or lactation 5) infection diseases 6) use of
 antidepressants, steroidal hormone drugs, mood stabilizers, caffeine, alcohol, or
 tobacco 7) histories of abdominal surgery for endometriosis or ovarian surgery