Low-Dose Leptin and the Formerly-Obese
Low-Dose Leptin and the Formerly-Obese
Our previous studies have demonstrated that there is substantial metabolic opposition to the
 maintenance of an altered body weight. Leptin is a protein secreted by fat cells and the
 circulating concentrations of leptin are directly proportional to fat mass. Leptin-deficiency
 is associated with severe obesity in rodents and in humans and the obesity is relieved by
 leptin administration. These studies examine the hypothesis that some of this metabolic
 opposition cto the maintenance of an altered body weight can be relieved by restoring
 circulating concentrations of the hormone leptin to the same range as at usual body weight in
 subjects who are maintaining a reduced body weight. The basic design of this study is to
 observe subjects at a 10% reduced body weight and then again at that reduced body weight
 while receiving physiological leptin or T3 supplementation.
We demonstrated a substantial metabolic resistance to maintenance of altered body weight.
 Leptin is secreted by fat cells in circulating concentrations that are directly proportional
 to fat mass. Leptin-deficiency is associated with severe obesity in rodents and in humans and
 the obesity is relieved by leptin administration. These studies examine the hypothesis that
 some of this metabolic opposition cto the maintenance of an altered body weight can be
 relieved by restoring circulating concentrations of the hormone leptin to the same range as
 at usual body weight in subjects who are maintaining a reduced body weight. The basic design
 of this study is to observe subjects at a 10% reduced body weight and then again at that
 reduced body weight while receiving physiological leptin or T3 supplementation.
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