Povidone-iodine Irrigation for Prevention of Intra-abdominal Abscess in Pediatric Perforated Appendicitis: A Multi-center Stepped Wedge Cluster Randomized Study
Povidone-iodine Irrigation for Prevention of Intra-abdominal Abscess in Pediatric Perforated Appendicitis: A Multi-center Stepped Wedge Cluster Randomized Study
The purpose of this study is to determine the effect of intra-abdominal irrigation with
 povidone-iodine (PVI) versus usual care on the rate of 30-day postoperative intra-abdominal
 abscesses (IAA) and to determine the effect of PVI irrigation versus usual care on 30-day
 hospital length of stay(LOS) and 30-day readmissions.
Inclusion Criteria:

 -  Admitted to a participating center

 -  Appendectomy performed for acute appendicitis

 -  Intraoperative diagnosis of perforated appendicitis

 Exclusion Criteria:

 -  Simple or gangrenous appendicitis

 -  Interval or incidental appendectomy

 -  Initial attempt at non-operative management (defined as >48 hours between the time of
 diagnosis and surgical intervention)

 -  History of iodine allergy, thyroid disease or renal dysfunction

 -  Pregnancy