Early Stop(Ruling) of the Antibiotic Treatment During Pneumopathies d' Inhalation
Early Stop(Ruling) of the Antibiotic Treatment During Pneumopathies d' Inhalation
The two most common consequences resulting from aspiration are chemical pneumonitis and
 bacterial aspiration pneumonia. Both entities present with comparable clinical signs and
 symptoms. In the absence of a reliable clinical or biological marker to differentiate between
 these two conditions, most patients with suspected aspiration are treated empirically with
 antibiotics. De-escalation of initial antibiotic treatment is encouraged based on the results
 of microbiological results, usually performed before starting antimicrobial treatment.
 However, in most hospitals, 48-72h are required to obtain the results of microbiological
 cultures, and to de-escalate empirical large spectrum antibiotic treatment.

 The use of the Unyvero®, a multiplex PCR-based testing system, for detection of respiratory
 bacterial pathogens would allow decreasing the percentage of patients with aspiration
 syndrome who will receive unappropriated antibiotic treatment at Day 3.
Inclusion Criteria:

 -  presence of risk factors for aspiration :

 -  known or likely swallowing dysfunction,

 -  altered consciousness,

 -  cardiac arrest,

 -  difficult intubation

 -  witnessed aspiration

 -  symptoms and signs suggestive of lower respiratory tract pathology

 -  temperature ≥38.5°C or <36°C

 -  leukocyte count ≥10 000/µL or <1500/µL

 -  purulent sputum or tracheal aspirate.

 -  new radiographic infiltrate on chest X-ray

 -  tracheal intubation and mechanical ventilation since less than 48 hours

 Exclusion Criteria:

 -  pregnant women

 -  refuse to participate to the study

 -  no informed consent

 -  documented bacteremia

 -  septic shock

 -  severe immunosuppression: leukocytes<1000/L or neutrophils<500/L, chemotherapy during
 the last 3 months, organ transplant with chronic immunosuppressors use, HIV (CD4<50),
 and chronic corticosteroid use (>0.5 mg/kg day for at least one month during the last
 three months).

 -  moribund patients (SAPS II >90).