Hyperbaric Oxygen Therapy Improves Outcome of Hypoxic-Ischemic Encephalopathy
Hyperbaric Oxygen Therapy Improves Outcome of Hypoxic-Ischemic Encephalopathy
The purpose of this study is to to evaluate the safety and efficacy of hyperbaric oxygen in
 term gestation newborn infants with hypoxic-ischemic encephalopathy..
Hypoxic-ischemic encephalopathy (HIE) remains a major cause of neonatal death and long term
 disabilities. Data from animal studies have shown protective effects of hyperbaric oxygen
 therapy to impaired brain. Recently research priorities have moved from bench to bedside.
 Several studies have shown a trend for brain protection of hyperbaric oxygen therapy has
 emerged as a promising treatment for HIE. Therefore,the investigators organized a
 multi-centered randomized controlled trial of hyperbaric oxygen therapy in HIE newborn
 infants.
-  Inclusion Criteria:

 -  Newborn infants whose gestational age ≥37 weeks' gestation, weighing over 2500 g
 ;

 -  Acute perinatal event (e.g., late or variable decelerations, cord prolapse, cord
 rupture, uterine rupture, maternal trauma, hemorrhage, or cardiorespiratory
 arrest)

 -  With an Apgar score ≤ 3 at one minute and ≤5 at five minutes, and/or a potential
 of hydrogen of 7.0 or less or a base deficit of 16 mmol per liter or more in a
 sample of umbilical-cord blood or any blood during the first hour after birth.

 -  Having moderate-to-severe encephalopathy (indicated by lethargy, stupor, or coma)
 and either hypotonia, abnormal reflexes (including oculomotor or pupillary
 abnormalities), an absent or weak suck, or clinical seizures, and/or have
 abnormal background activity of at least 20 minutes' duration or seizures on
 amplitude integrated electroencephalography

 -  Exclusion Criteria:

 -  A congenital and the hereditary disease, a chromosome abnormalities, and a
 congenital abnormality.

 -  During the acute phases of intracranial and (or) fundus hemorrhage. o

 -  Intracranial infection.

 -  Pneumothorax.

 -  Infants who have been received hypothermia.