High Flow Nasal Oxygen Therapy in Perioperative Period of the Adult With Hypercapnic and Hypoxemic Respiratory Faliure
High Flow Nasal Oxygen Therapy in Perioperative Period of the Adult With Hypercapnic and Hypoxemic Respiratory Faliure
The purpose of this study is to determine the impact of hign-flow nasal therapy on the adult
 with hypercapnia and hpoxemia respiratory faliure in comparison with standard oxygen therapy
 ang noninvasive ventilation.
Humidified high flow nasal oxygen therapy decreases dilution of the inhaled oxygen and, by
 matching patient's peak flow, allows accurate delivery of the set FiO2 throughout the whole
 inspiratory phase.The purpose of this study is to determine the impact of hign-flow nasal
 therapy on adult hypercapnic respiratory failure by comparing with nasal continuous positive
 airway pressure
Inclusion Criteria:

 -  Hypoxemic and no hypercapnic acute respiratory failure :

 -  severe dyspnea at rest with a respiratory rate >25 breaths/min

 -  PaO2/FiO2 <300

 -  PaCO2 <45 mmHg,

 Exclusion Criteria:

 -  age <18 years

 -  NPPV contraindications

 -  past history of respiratory chronic disease (COPD, cystic fibrosis…)

 -  cardiac pulmonary edema

 -  Pre-defined intubation

 -  other than respiratory organ failure : systolic pressure <90 mmHg,current treatment
 with epinephrine or norepinephrine, decreased level of consciousness ( Glasgow score ≤
 12)

 -  profound aplasia (white cells count <1000/mm 3)