A Study Comparing Long-acting Methylphenidate (ConcertaTM) vs. Placebo in the Treatment of Memory Loss Due to HIV
A Study Comparing Long-acting Methylphenidate (ConcertaTM) vs. Placebo in the Treatment of Memory Loss Due to HIV
This study is being done to see if a drug called long acting methylphenidate (Concerta) is
 safe and effective as a treatment for problems with mental function in adults infected with
 HIV.

 A subset of patients with HIV-associated memory loss have a defect in the speed with which
 they learn and process information. Methylphenidate drugs, such as Ritalin or Concerta, have
 been shown on tests to improve the ability to rapidly absorb information; these tests are
 called "reaction time tests". These drugs are already FDA-approved to treat Attention Deficit
 Disorders: ADD or ADHD.

 At baseline, all subjects get tests of memory and brain function; then they are split into
 two groups. One group on this study will receive Concerta for 2 weeks, and a second group
 will receive a placebo x 2 weeks. After that period both groups will receive memory and other
 tests of brain function, and then the groups will switch. The first group will receive
 placebo and the second will receive Concerta x 2 weeks, followed by more memory and
 neurological tests. After that all subjects will have the option to receive Concerta for free
 for 8 more weeks. At the last visit all subjects get memory and brain tests again.
There are 11 study visits in 14 weeks.

 In Part I of the study one-half of the subjects will receive ConcertaTM and one-half will
 receive placebo.

 After 2 weeks all subjects will stop their study medication for 2 week (the "washout
 period"), and then all of the subjects who received placebo will then receive 2 weeks of
 methylphenidate, and all of the subjects who received long acting methylphenidate will
 receive placebo for 2 weeks.

 The subject will be invited to enter Part II of the study if she/he still qualifies. During
 this portion of the study, the subject will receive ConcertaTM for 8 weeks. The subject does
 not have to be on Part II of this study to be on this study.

 Screening visit. (4 hours)

 There is a screening medical visit. If the subject passes the initial questions for
 depression and dementia, the subject will undergo the following procedures:

 There will be a physical examination including a medical and medication history, which will
 include telling the study staff about all of the drugs that the subject has taken recently or
 are currently taking, and measurement of vital signs (blood pressure, temperature, height,
 weight, pulse,breathing rate).

 The subject will have a physical examination including a detailed test of reflexes, muscle
 strength,gait, balance, and other functions of brain and nerves to see if he/she has any
 nerve damage and to see how the brain functions. The subject will take a group of tests
 called neuropsychological tests. The subject will answer questions, do simple tasks with
 their hands, and see how long it takes her/him to walk a short distance. Some of these
 questions are to test the subject for depression and memory abilities.

 The subject will need to bring in your most recent CD4 cell count (T-cell counts) and HIV
 viral load on this visit.

 If the initial screening questionnaires show that the subject fulfills some of the
 requirements of the study, the subject will be asked to have about 2 tablespoons of blood
 drawn from a vein in his/her arm, a urine test for drugs of abuse, and a urine pregnancy test
 if the subject is female and able to bear children. Some of the blood tests are to measure
 liver and kidney function and to see if the subject is anemic. The subject will have an EKG
 (electrocardiogram).

 . Entry Visit (Week 0) If the subject qualifies for this study the subject will return to the
 clinic for an entry visit. The entry visit will occur within 2 weeks of Visit 1. This visit
 will take about 3-4 hours. At this visit you will undergo the following procedures: The
 subject will have a short physical examination and be asked questions about your health and
 the medications she/he is taking. The subject will be asked to complete another set of tests
 of memory and mental function. If the subject is a woman of child bearing potential he/she
 will have a pregnancy test at this visit and every 4 weeks thereafter. Once the subject has
 completes the entry tests, she/he will be assigned by chance (like flipping a coin) to either
 ConcertaTM, or placebo.

 The study treatment groups are:

 Group A: ConcertaTM 2 tablets taken with food in the morning OR Group B: Placebo, 2 tablets
 taken with food in the morning.

 The first dose of study medication will be given in the clinic. She/he will be asked to take
 1 tablet of study medication in the clinic and be observed for 2 hours afterward to see if
 you have any immediate side effects. The blood pressure will be checked again. The first dose
 of study medication is only 1 tablet of the study medication. On the day after this clinic
 visit she/he will take your second dose of study medication. This will be 2 tablets of study
 medication. Thereafter the subject will be taking 2 tablets of study medication in the
 morning. The study medications will be given as a 2-week supply.

 Week 1 Visit (1 hour) The subject will be asked brief medical questions and receive a brief
 physical exam with vital signs and an EKG if indicated. She/he will be asked for a urine
 sample. She/he will have one short memory test.

 Week 2 Visit (3 hours) He/she will be asked to come to clinic before he/she takes the daily
 dose of study medication. He/she are asked to bring your study medications with them, and to
 take the study medication in the presence of the study staff, who will note the time. He/she
 will be asked brief medical questions and receive a brief physical exam and a detailed test
 of his/her brain and nerve function. He/she will have an EKG and a blood test of about 2
 tablespoons to check liver and kidney function, and to check for anemia.

 She/he will also be asked questions about emotions, memory function, and ability to do simple
 tasks. If she is a woman able to become pregnant she will be asked to have a urine pregnancy
 test. After this visit the subject will stop taking study medications for 2 weeks (2 week
 washout period).

 Week 4 (4 hours) He/she will be asked brief medical questions and receive a brief physical
 exam, and a detailed test of brain and nerve function. He/she will be asked questions about
 emotions, memory function, and ability to do simple tasks. He/she will be given a new supply
 of study medications. The subject will be asked to take 1 tablet of study medication in the
 clinic and be observed for 2 hours afterward to see if he/she has immediate side effects.
 Blood pressure will be checked again. On the day after this clinic visit the subject will
 take 2 tablets of study medication. Thereafter the subject will be taking 2 tablets of study
 medication in the morning.

 Week 5 (1 hour) The subject will be asked brief medical questions and receive a brief
 physical exam and an EKG if indicated. The subject will be asked for a urine sample. He/she
 will have one short memory test.

 Week 6 (4 hours) The subject will be asked to come to clinic before he/she takes the daily
 dose of study medication. The subject is asked to bring your study medications with them, and
 to take the study medication in the presence of the study staff, who will note the time.
 He/she will be asked brief medical questions and receive a physical exam and a detailed test
 of brain and nerve function. The subject will be asked questions about emotions, memory
 function, and ability to do simple tasks. The subject will have a blood test (about 2
 tablespoons) to check kidney and liver function, and to check for anemia. The subject will
 have an EKG. If she is a woman able to become pregnant she will be asked to have a urine
 pregnancy test.

 After the Week 6 visit is completed, and if blood and other tests indicate that the subject
 is still eligible, the subject will be invited to enter the Part II phase of the study. In
 the Part II phase,and sign a new consent. In Part II all subjects will receive ConcertaTM for
 the next 8 weeks. After the new consent is signed, the subject receives a two week supply of
 Concerta.

 Week 8 (1 hour) The subject will be asked brief medical questions and receive a brief
 physical exam and an EKG if indicated. He/she will be given a 2 week supply of Concerta.

 Week 10 (1 hour) The subject will be asked brief medical questions and receive a brief
 physical exam and an EKG if indicated. If she is female she will be asked to give urine for a
 pregnancy test .The subject will be given a new 2-week supply of Concerta.

 Week 12 (1 hour) The subject will be asked brief medical questions and receive a brief
 physical exam and an EKG if indicated. He/she will be given a 2 week supply of Concerta.

 Week 14 (4 hours) The subject will be asked brief medical questions and receive a physical
 exam including vital signs and a detailed test of brain and nerve function. He/she will be
 asked questions about emotions, memory function, and ability to do simple tasks. She/he will
 again receive memory questionnaires and a quality of life questionnaire. She/he will receive
 an EKG. If she is a woman able to become pregnant she will be asked to have a urine pregnancy
 test. After thisvisit the study ends.
Inclusion Criteria:

 Men and women 18 years of age or older and less than 65 years of age.

 Able to read and understand English.

 HIV infected on stable ART regimen for 5 months or greater, and not likely to change
 regimen for the duration of the study.

 Significant dementia but able to give consent (International HIV Dementia Scale score <10).

 Significant cognitive slowing on screening, defined as 1 SD below normal (t-score >60) on
 the Conner's CPT-II reaction time test.

 Beck Depression Inventory score <16.

 Documented HIV-1 RNA PCR <50 copies/mL and documented CD4 count >200 within 3 months of
 entry visit.

 Baseline CBC and chemistry panel Grade 1 or normal.

 For females of reproductive potential (women who have not been post-menopausal for at least
 24 consecutive months, i.e., who have had menses within 24 months prior to study entry), or
 women who have not undergone surgical sterilization, specifically hysterectomy or bilateral
 oophorectomy or tubal ligation) will require a negative serum or urine pregnancy test
 within 48 hours prior to entry.

 NOTE: Subject reported history is considered acceptable documentation of hysterectomy,
 bilateral oophorectomy, tubal ligation, tubal micro-inserts, menopause, and
 vasectomy/azoospermia.

 All subjects must agree not to participate in the conception process (e.g., active attempt
 to become pregnant or to impregnate, sperm donation, in vitro fertilization), and if
 participating in sexual activity that could lead to pregnancy, the subject/partner must use
 at least two reliable methods of contraception, (condoms, without a spermicidal agent; a
 diaphragm or cervical cap without spermicide; an IUD; or hormone-based contraceptive), for
 2 weeks before study treatment, while receiving study treatment, and for 6 weeks after
 receiving study treatment.

 Ability and willingness of subject to provide informed consent.

 Exclusion Criteria:

 Inability to give informed consent. No proxy consent allowed.

 Uncontrolled hypertension (SBP >140 and DBP >90 at screening and baseline).

 Untreated hypogonadism, hypothyroidism or hyperthyroidism.

 Initiation of antidepressants, thyroid medication or anabolic steroids within 6 weeks of
 screening visit.

 Pregnancy or breast feeding.

 Clinically significant EKG abnormalities at screening.

 History of coronary artery disease, atherosclerotic disease, left ventricular hypertrophy,
 cardiomegaly, syncope, congestive heart failure, myocardial infarction, pacemaker,
 clinically significant arrhythmia, angina, history of treatment for arrhythmia.

 Brain related opportunistic infections, stroke, intracranial lesions/disease, or
 meningitis.

 History of epilepsy.

 Untreated depression.

 Uncontrolled diabetes (glucose <70 or >200 at screening).

 Use of interferon or ribavirin during study and for 1 month prior to screening.

 History of bipolar disorder, Alzheimer's dementia, ALS, Parkinson's disease or other
 medical dementias other than HIV-related.

 History of schizophrenia, mania or other serious mental illness.

 History of methylphenidate allergy.

 Other serious concurrent medical illness other than HIV.

 History of radiation therapy to the brain or brain injury.

 History of crystal methamphetamine, cocaine, LSD use or other recreational substance use
 other than marijuana within the 12 months prior to screening and for the duration of the
 study.

 Plan to use marijuana or marinol during the entire study duration and one month prior to
 screening visit.

 Plan to drink 7 or more alcoholic drinks per week during the 4 weeks prior to screen visit
 and for the duration of the study.

 History of alcohol dependence, alcohol abuse, cocaine addiction, crystal methamphetamine
 addiction or other recreational drug addiction or treatment for addiction or dependence
 within 5 years of screening visit.

 If subject is using prescription narcotics, should be on a stable dose for at least 1 month
 prior to screening and throughout the study.

 Previous use of Concerta™, Ritalin™, atomexitine or Adderall™ or other psychostimulants
 (e.g. modafinil, armodafinil) for 3 months prior to screening visit and for duration of the
 study.

 History of tic disorders in the past 3 months or any history of Tourette's syndrome.

 Greater than 10% below ideal body weight (IBW for men = 50 kg + 2.3 kg per inch over 5 feet
 of height, and IBW for women = 45.5 kg + 2.3 kg per inch over 5 feet of height)

 Uncontrolled migraine headaches.

 History of short gut syndrome, Meckel's diverticulum, or cystic fibrosis.

 Family history of sudden cardiac death in a young relative.

 History of fainting with exercise.

 History of attention deficit disorder will be excluded, defined as a score greater than 6
 on the Childhood ADHD Symptoms Scale.

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