A National Study in Patients With Unexplained Splenomegaly
A National Study in Patients With Unexplained Splenomegaly
Primary Objective:

 To estimate the prevalence of Gaucher disease and of other etiologies, in patients of 15
 years old or more presenting with unexplained splenomegaly after exclusion of first
 intention-diagnoses (e.g. portal hypertension, diagnosis or suspicion of haematological
 malignancy, haemolytic anemia) based on basic physical and biological exams (e.g. full blood
 count, liver enzymes, reticulocytes)

 Secondary Objective:

 To describe the exams and tests conducted for diagnosis purpose and the more frequent
 associations
Study duration per participant is between 1 and 12 months
Inclusion criteria:

 -  Participants referred for the first time for splenomegaly exploration defined as :

 -  Either a palpable mass on left upper abdominal quadrant, further confirmed by a ≥
 13 cm craniocaudal length on abdominal Imaging

 -  Or a non palpable splenomegaly discovered on abdominal imaging and with a
 craniocaudal length ≥ 13 cm

 -  Participants with splenomegaly (as defined above) of unknown origin

 Exclusion criteria:

 -  Participants with obvious diagnostics based on clinical exam, patient's interview and
 the previous initial routine biological tests :

 -  Diagnosis of portal hypertension

 -  Diagnosis of hemolytic anemia

 -  Diagnosis of hematological malignancy

 -  Known diagnosis of Gaucher Disease

 The above information is not intended to contain all considerations relevant to a patient's
 potential participation in a clinical trial.