Edwards PASCAL CLASP IID/IIF Pivotal Clinical Trial
Edwards PASCAL CLASP IID/IIF Pivotal Clinical Trial
To establish the safety and effectiveness of the Edwards PASCAL Transcatheter Valve Repair
 System in patients with degenerative mitral regurgitation (DMR) who have been determined to
 be at prohibitive risk for mitral valve surgery by the Heart Team, and in patients with
 functional mitral regurgitation (FMR) on guideline directed medical therapy (GDMT)
A prospective, multicenter, randomized, controlled pivotal trial to evaluate the safety and
 effectiveness of transcatheter mitral valve repair with the Edwards PASCAL Transcatheter
 Valve Repair System compared to Abbott MitraClip in patients with degenerative mitral
 regurgitation (DMR) who have been determined to be at prohibitive risk for mitral valve
 surgery by the Heart Team, and in patients with functional mitral regurgitation (FMR) on
 guideline directed medical therapy (GDMT)

 Patients will be seen for follow-up visits at discharge, 30 days, 6 months, and annually
 through 5 years.
Inclusion Criteria:

 -  Eighteen (18) years of age or older

 -  Patient is able and willing to give informed consent and follow protocol procedures,
 and comply with follow-up visit requirements.

 -  Patient is determined to be at prohibitive risk for mitral valve surgery by the heart
 team (CLASP IID cohort only).

 -  Patient is on stable heart failure medications/Guideline Directed Medical Therapy
 (CLASP IIF cohort only)

 -  Patient is determined to be a candidate for transcatheter mitral valve repair by the
 heart team for both PASCAL and MitraClip

 -  Mitral regurgitation (3+ to 4+) by echo

 -  Suitable valve and regurgitant jet morphology

 -  Elevated BNP > 150 pg/ml or corrected NT-pro BNP of > 600 pg/ml or heart failure
 hospitalization within the past 12 months (CLASP IIF cohort only)

 Exclusion Criteria:

 -  Patient in whom a TEE is contraindicated or screening TEE is unsuccessful

 -  Mitral valve anatomy which may preclude proper PASCAL or MitraClip access, use and/or
 deployment or sufficient reduction in mitral regurgitation

 -  Patient with refractory heart failure requiring advanced intervention (i.e. left
 ventricular assist device, transplantation) (ACC/AHA Stage D heart failure)

 -  Clinically significant, untreated coronary artery disease

 -  Recent stroke

 -  Other severe valve disorders requiring intervention

 -  Need for emergent or urgent surgery for any reason or any planned cardiac surgery
 within the next 12 months

 -  Any prior mitral valve surgery or transcatheter mitral valve procedure (excluding
 chordal replacement or surgical annuloplasty repair)

 -  Active rheumatic heart disease or rheumatic etiology for MR

 -  Severe aortic stenosis or regurgitation

 -  Known history of untreated, severe carotid stenosis

 -  History of deep vein thrombosis (DVT) or pulmonary embolism (PE)

 -  Severe COPD

 -  Pregnant or planning pregnancy within next 12 months. Note: Female patients of
 childbearing potential need to have a negative pregnancy test performed within 14 days
 prior to intervention and be adherent to an accepted method of contraception

 -  Concurrent medical condition with a life expectancy of less than 12 months in the
 judgment of the Investigator

 -  Patient is currently participating in another investigational biologic, drug or device
 clinical study where the primary study endpoint was not reached at time of enrollment

 -  Other medical, social, or psychological conditions that preclude appropriate consent
 and follow-up, including patients under guardianship