Acute Stress Response in Migraine Sufferers
Acute Stress Response in Migraine Sufferers
This study will examine the influence of stress and fasting on headache activity.
 Participants will receive both a control and stress session and be randomized to either
 fasting or not fasting for the visits.
Stress and headache are intricately interrelated. Stress is thought to contribute to headache
 disorder onset in predisposed individuals, trigger or worsen individual headache episodes in
 those with headache, and exacerbate the progression of a headache disorder. In exacerbating
 headache disorder progression, stress is believed to be a major factor in headache
 transformation from an episodic to a chronic condition.

 Broadly stated, stress is conceptualized as an imbalance between a demand, whether actual or
 perceived, and resources to handle the demand, resulting in a strain on the system. A
 stressor is any challenge or threat, whether objectively verified or not, to normal
 functioning. The stress response is the body's activation of physiological systems to protect
 and restore functioning.

 This study is 2 x 2 experiment using male and female migraine sufferers. Participants will be
 randomized to a fasting or not fasting condition for the visits. Thus, the experiment is a 2
 (control versus stress) x 2 (fasting versus not). During the approximately 4 weeks of
 participation (ranging from 9 to a maximum of 28 days), a participant also will complete a
 twice-daily diary.
Inclusion Criteria:

 -  Women and men 18-65 years of age

 -  A provisional diagnosis of migraine (with or without aura).

 -  Headache frequency of 2 to 15 attacks/month

 Exclusion Criteria:

 -  Presence of a secondary headache disorder (e.g., brain tumor)

 -  Chronic daily headache (> 15 headache days/month) or medication over-use headache (> 8
 abortive medication doses/month)

 -  Recent change in nature of headache symptoms over last 6 weeks

 -  Not being able to read or speak English at a 6th grade level

 -  Any condition that would preclude the safe experience of a benign laboratory stressor
 including seizure disorder, Axis-I psychotic disorder, unstable cardiac conditions

 -  An active substance dependence issue (e.g., alcohol, marijuana) that interferes with
 data collection and headache activity.