Role of Leukocyte- and Platelet-Rich Fibrin Membranes in Endoscopic Endonasal Skull Base Reconstruction
Role of Leukocyte- and Platelet-Rich Fibrin Membranes in Endoscopic Endonasal Skull Base Reconstruction
Prospective investigation of the effectivity of L-PRF membranes for skull base reconstruction
 after endoscopic endonasal skull base surgery (transsphenoidal) versus classical closure
 techniques.
The investigators want to demonstrate in a prospective, randomized trial including 220
 patients undergoing endoscopic endonasal skull base surgery that the use of L-PRF is
 non-inferior to classical fibrin sealants.

 Approximately 220 patients undergoing cranial surgery will be enrolled in this randomized,
 controlled, single-blinded multicenter study to evaluate the safety and effectiveness of
 autologous blood-derived products (L-PRF and fibrinogen) compared to the fibrin sealants as
 an adjunct for dural repair.
Inclusion Criteria:

 -  Patients with lesions of the sellar/parasellar region

 -  Age > 18 and < 70 years

 -  Written informed consent

 -  Willingness to adhere to visit schedules

 Exclusion Criteria:

 -  Age < 18 and > 70 years

 -  Any underlying rhinological condition like nasal polyps, which may interfere with the
 obtained results

 -  Any disorder which might compromise the ability of a patient to give truly informed
 consent for participation in this study

 -  Enrollment in other investigational drug trial(s)