The Effect on Knee Joint Loads of Analgesic Use Compared With Exercise in Patients With Knee Osteoarthritis - An RCT
The Effect on Knee Joint Loads of Analgesic Use Compared With Exercise in Patients With Knee Osteoarthritis - An RCT
The purpose of this study is to compare the effects of neuromuscular exercise and analgesic
 use on knee joint load, in patients with mild to moderate knee osteoarthritis (OA).

 It is expected that the two groups will receive equipotent pain relieving effect, despite
 this, the investigators expect a between group difference in knee joint load, and the
 exercise group will have a reduction in knee joint load.
Inclusion Criteria:

 -  Compliance with the ACR criteria

 -  Medial knee OA defined as "No osteoarthritis", "Doubtful narrowing of joint space
 and/or possible osteophytes", "Definite osteophytes and possible narrowing of joint
 space", "Multiple osteophytes, definite narrowing of joint space and some sclerosis
 and deformity of bone ends". This corresponds to the Kellgren and Lawrence (KL) grades
 0, 1, 2 and 3 respectively

 -  Willingness to participate in exercise and use of analgesics

 -  A maximum of 75/100 points in the KOOS Pain subscale

 -  BMI of 32 or less

 Exclusion Criteria:

 -  Medial greater than lateral joint space width

 -  Medial knee OA of KL grade 4

 -  Knee surgery or steroid injection within the past 6 months

 -  Already taking max dose NSAIDs or acetaminophen

 -  Any physician-determined condition that is a contraindication for use of
 acetaminophen, NSAIDs or to exercise

 -  Problems affecting the lower extremity overriding the problems from the knee

 -  Knee surgery planned in the next 6 months

 -  Known ACL tear within the past 6 months

 -  ACL reconstruction

 -  Diagnosis of systemic arthritis

 -  Difficulty complying with treatment schedule

 -  Inability to fill out questionnaires

 -  Inability to ambulate without an assistive device

 -  Ankle, knee or hip replacement

 -  Tibial/femoral osteotomy