Acupuncture and Gonadotropin-releasing Hormone Pulse Generator and Stress Axis in Polycystic Ovary Syndrome
Acupuncture and Gonadotropin-releasing Hormone Pulse Generator and Stress Axis in Polycystic Ovary Syndrome
Hypothesis The overall hypothesis is that non-obese (BMI <30) women with PCOS have high
 luteinising hormone (LH) and cortisol pulse frequency and amplitude and that repeated
 low-frequency EA restore these alterations and induce ovulation.
Aim 1. Elucidate if low-frequency EA induce ovulation and restore LH frequency and amplitude
 as well as sex steroid secretion as compared to a control group receiving same amount of
 attention.

 Aim 2. Elucidate if low-frequency EA restore cortisol frequency and amplitude compared to a
 control group receiving same amount of attention.

 Aim 3. Elucidate if low-frequency EA restore psychological distress and quality of life as
 compared to a control group receiving same amount of attention.in women with PCOS.
Inclusion Criteria:

 -  18 - 39 years, inclusive

 -  30 ≤ BMI

 -  History of irregular menstrual cycles

 -  Clinical and/or biochemical androgen excess (determined during screening)

 Exclusion Criteria:

 Medical Exclusion Criteria

 -  History or clinical manifestation of; cardiovascular disease, diabetes (Type 1 or Type
 2), any other significant endocrine or metabolic disorder.

 -  Regular use of medications for weight control, psychosis and thyroid disease. A 3
 month washout period will be permitted for contraceptives.

 Psychiatric and Behavioral Exclusion Criteria

 -  Pregnant or breast-feeding women