MRI for the Early Evaluation of Acute Intracerebral Hemorrhage
MRI for the Early Evaluation of Acute Intracerebral Hemorrhage
What happens in the borderzone of a cerebral hemorrhage remains widely onknown and furhter
 the best timing for doing MR to look for vascular pathology in cerebral hemorrhage has not
 yet been determined. In this study we do acute MRS, a non-invasive imaging mathod to detemine
 the biochemsty in the border zone and structural MRI for vascular malformation. We repeat
 structural MRI after 8 weeks.
In this study we want to investigate the ability of MRI to identify underlying pathology
 (tumor or vascular malformations) in acute patients admitted with intracerebral hemorrhage
 (ICH). Today MRI-scan is normally done 3-4 weeks after symptom onset but very little is known
 about the early use of MRI to detect underlying pathology. This would allow an early
 intervension and less uncertainty for the patients.

 We further want to investigate the metabolic penumbra-zone surrounding the hematoma. It is
 the current perception in the litterature that this zone represent a metabolic zone marked by
 apoptosis and inflammation rather than ischemia.

 We are planning to:

 When patients arrive in our stroke department they will within 7 hours be subject to MRI scan
 with the protocoled sequences. Standard sequences: Axial T2, axial DWI, Sagittal T1, T2 flair
 og axial GRE-sequence.

 Susceptibility weighted imaging (SWI)

 Chemical Shift Imaging (CSI) multivoxel spectroscopi

 Post contrast 3D box reconstruction

 After 8 weeks the patients are subject to another MRI-Scan in accordance with the standard
 clinical guideline to rule out underlying pathology.

 After 3 month the patients are seen in the outpatient-clinic to follow-up evaluation.

 To sum up the purpose of this present study is to conduct a pilot investigation of MRI in the
 early evaluation of ICH-patients. Second it is our intension to use multivoxel magnetic
 resonance spectroscopy to study the metabolic penumbra-zone surrounding the ICH.
Inclusion Criteria:

 -  CT demonstrated ICH

 -  Cardiopulmonary stable

 -  Informed consent from patient or proxy

 -  No General contraindication of MRI

 -  Age above 18

 Exclusion Criteria:

 -  Lack of informed consent

 -  lack of cooperability