Change in Thrombin Generation Potential and Thromboelastography During the Menstrual Cycle
Change in Thrombin Generation Potential and Thromboelastography During the Menstrual Cycle
The primary objective of this study is to describe characteristics and trends for thrombin
 generation (TG) and thromboelastography (TEG) at 4 time points during the menstrual cycle.
We propose that TG and TEG will be more sensitive than traditional coagulation assays to
 detect physiologic variation in hemostasis, fibrinolysis, and platelet activation throughout
 the menstrual cycle. We expect that TG and TEG will better discriminate patients with vWD
 than traditional coagulation studies during the menstrual cycle. In this study we plan to
 measure TG and TEG in healthy women and women with von Willebrand's disorder during four
 phases of the menstrual cycle. We will compare specific measurements of endogenous thrombin
 generation potential from the TG and fibrinolysis and platelet activation from the TEG with
 standard measures of coagulation, fibrinolysis, and platelet activation markers during the
 menstrual cycle.
Inclusion Criteria:

 -  Females of reproductive age with regular menstrual cycles and a diagnosis of von
 Willebrand disease according to the International Society of Thrombosis and Hemostasis
 diagnostic criteria.

 Exclusion Criteria:

 -  Females who are pregnant, or have a history of endocrinopathy or hormone imbalance

 -  History of hysterectomy or bilateral oophorectomy

 -  History of ovarian or uterine cancer

 -  Use of intrauterine device

 -  Use of antifibrinolytic therapy, hemostatic agents, or anti-platelet agents.