Study of AQUACEL™ Ag Surgical Cover Dressing Following Total Knee Replacement
Study of AQUACEL™ Ag Surgical Cover Dressing Following Total Knee Replacement
The aim of the study is to determine whether the AQUACEL™ Ag SURGICAL cover dressing is
 successful in reducing the incidence of wound infection in high risk patients following total
 knee replacement. We will also look at the status of the wound, occurrence of blistering,
 biochemistry results, dressing wear time and the number of dressing changes to quantify the
 dressing performance.
All eligible patients over a two month period will be identified and invited to take part in
 the study. Identification will be done though examination of clinical case notes of patients
 who are candidates for total knee replacement or revision surgery. Demographic and medical
 history data for all study patients will be collected. This will include age, gender, BMI,
 smoking habits, alcohol consumption, diagnosis, operation, laterality and comorbidities. All
 eligible patients who fulfil the selection criteria will be informed of the study at their
 pre-surgery consultation, provided with the patient information sheet and approached to take
 part in the study at a later date.

 Patients who have agreed to take part in the study will have their knee surgery performed in
 the same manner as if they had not agreed to take part. The clinical team will be informed of
 a patient's participation in the study and will ensure that the AQUACEL™ Ag SURGICAL cover
 dressing is used instead of the standard dressing protocol with these patients, both
 immediately after surgery and at any other time when the patient requires the dressing to be
 changed before discharge. Study patients will also be given a sufficient supply of the
 dressing for home use on discharge from the hospital.

 Patients will be observed during their inpatient stay where data including the wound status,
 occurrence of blistering, dressing wear time, number of dressing changes, ease of dressing
 changes, any unforeseen side effects and any surgical site infection will be recorded to
 quantify the dressing performance by the healthcare staff. Appropriate data from lab results
 will be extracted. After discharge, data will be collected from the Prevention and Control of
 Infection team at regular intervals up to 30 days postoperatively. Study patients will be
 followed up, as per hospital protocol, at six weeks by the Arthroplasty Outcomes team. Data
 from this follow up will also be included in the study. After this appointment, patients will
 no longer have any involvement in the study.

 Once the data set is completed statistical analysis will be carried out to compare the
 results of this study with those of a retrospective cohort study of a similar patient group,
 where the Jubilee method dressing (a combination of DuoDERM® and AQUACEL® was used).
Inclusion Criteria:

 -  BMI ≥ 40

 -  Revision of total knee replacement

 -  Rheumatoid arthritis or secondary arthritis

 -  Patients on Warfarin

 -  Patients on steroids

 -  Patients on long term antibiotics

 -  Previous deep joint infection

 Exclusion Criteria:

 -  Allergy to silver

 -  Simultaneous bilateral total knee replacement patients

 -  Patients who do not wish to participate

 -  Patients who are unable to give informed consent

 -  Patients who are unable to attend Golden Jubilee National Hospital for follow up