Stimulation to Improve Memory
Stimulation to Improve Memory
This study will test the effects of different doses of a form of non-invasive brain
 stimulation for the treatment of individuals with mild cognitive impairment (MCI) and
 dementia of the Alzheimer's Type (DAT).
This research study is being done to learn important information about the effects of weak
 electrical stimulation on brain functioning in those with mild cognitive impairment (MCI) and
 dementia of the Alzheimer's type (DAT). The findings will help determine "how much"
 stimulation is needed to enhance memory and thinking abilities, how it affects brain
 functioning, and who is most likely to benefit. Ultimately, this information may guide
 treatment efforts for those at various stages of Alzheimer's disease. The study will use
 brain imaging to see whether these treatments change how participants learn and remember
 information. Functional magnetic resonance imaging (fMRI) and positron emission tomography
 (PET) scans will be used. The study will also use cognitive tests and questionnaires to
 examine whether participants' memory (and related abilities) change because of treatment. The
 study will enroll participants with a diagnosis of MCI or DAT. It is expected but not
 required that participants will be co-enrolled in the University of Michigan Memory and Aging
 Project (UM-MAP; HUM00000382).
Inclusion Criteria:

 1. Diagnosis of Mild Cognitive Impairment (MCI) or dementia of the Alzheimer's type (DAT)

 2. Must be MRI compatible, criteria that also apply for High Definition transcranial
 direct current stimulation (HD-tDCS; e.g., absence of metallic or electronic implants
 in the upper body or head)

 3. Stable on relevant medications for at least 4 weeks prior to study enrollment

 Exclusion Criteria:

 1. Certain neurological diseases

 2. Certain psychiatric conditions

 3. Severe sensory impairment