Predicting Risk Factors for Exacerbation of Chronic Obstructive Pulmonary Disease
Predicting Risk Factors for Exacerbation of Chronic Obstructive Pulmonary Disease
Exacerbations of chronic obstructive pulmonary disease (COPD) are unfavourable events in the
 course of disease for most COPD patients. Published evidence indicates a significant impact
 of exacerbations, especially if frequent, on patients' health-related quality of life (HRQL),
 disease progression, mortality, health care utilisation and costs. However, the
 severity,evolution and outcome of an exacerbation may differ significantly between patients -
 some patients will recover completely in a short period of time while others may die. The
 identification of risk factors for an adverse outcome could help in distinguishing patients
 who require more intense management in order to prevent failures, achieve satisfactory
 recovery and reduce the negative clinical and socioeconomic impact of exacerbations.The
 pathogenesis of COPD is still unclear, so there is no specific treatment at present .COPD was
 considered to be the result of a combination of environmental and genetic factors. Genetic
 factors play an important role in the acute exacerbation of COPD.Therefore, it is an urgent
 need to explore the heterogeneity of COPD phenotype from the perspective of genes and to seek
 individualized prevention and treatment programs.This study is intended to provide a
 theoretical basis for the prevention, evaluation and development of individualized treatment
 plans for acute exacerbation of COPD, thereby improving the prognosis of the disease.
Inclusion Criteria:

 -  Clinical diagnosis of Chronic obstructive pulmonary disease

 -  aged >= 40 years

 Exclusion Criteria:

 -  spirometry can not be completed because of various reasons

 -  asthma

 -  pulmonary embolism

 -  lung cancer

 -  sequelae of tuberculosis

 -  extensive bronchiectasis

 -  interstitial lung disease

 -  left cardiac insufficiency