Project AWARE: Using the Emergency Department (ED) to Prevent Sexually Transmitted Infections (STIs) in Youth
Project AWARE: Using the Emergency Department (ED) to Prevent Sexually Transmitted Infections (STIs) in Youth
Project Aware introduces a sexually transmitted infection (STI) screening model for sexually
 experienced adolescents aged 14 to 21 in a large, inner-city Emergency Department (ED) in the
 Bronx, N.Y. Project Aware will scaffold routine, rapid testing and counseling for Chlamydia
 trachomatis (CT) and Neisseria gonorrhoeae (GC) onto an existing, successful, ED-based HIV
 testing and counseling program, Project BRIEF. Project Aware will educate and motivate youth
 to use condoms with the aid of a theory-based, youth-friendly multimedia behavioral
 intervention proven to be effective during the investigator's K23 training. Through Project
 Aware, the investigators propose to change the paradigm of STI testing. Whereas a view of
 "HIV exceptionalism" has persisted in U.S. health policies on STI testing, the investigators
 propose a comprehensive approach, in which efforts to identify, treat, and prevent multiple
 STIs coalesce in one program. The research study has two phases. In the production phase, new
 STI material will be added to the multimedia intervention currently used for HIV education.
 In the evaluation phase, a randomized controlled trial (RCT) will be conducted to assess the
 effectiveness of Project Aware in identifying, treating, and preventing new STI infections
 among high-risk adolescents. The RCT is designed to test the incremental effectiveness of
 three STI prevention methods: (1) HIV testing and counseling (T&C), (2) HIV T&C and STI
 testing, and (3) HIV/STI Testing plus a point-of-service risk reduction video that
 incorporates both HIV and STI counseling and education. The study is powered to examine three
 STI prevention outcomes: (1) the number of STI infections identified and treated successfully
 at baseline; (2) the number of new STI infections over the 12 months following study entry,
 identified by (a) performing STI testing at each follow-up assessment; and (b) obtaining
 anonymized rate data on STIs reported to the New York City Department of Health; (3) condom
 use behavior. 600 youth aged 14-21 will be enrolled in the RCT. Youth will be approached in
 the ED waiting room and recruited by Public Health Advocates. All will complete a survey to
 screen for eligibility; eligible youth will complete the baseline measures and be randomized.
 The follow-up data points and measures will be followed at 4, 8 and 12 months (4 time points)
 and STI testing will be included.
Almost half of all new sexually transmitted infections (STIs) occur in young people aged
 15-24.1 The vast majority (88%) consists of chlamydia (CT), gonorrhea (GC), human papilloma
 virus (HPV), and trichomoniasis.1 Additionally, the Centers for Disease Control and
 Prevention (CDC) reported that young people aged 15-24 accounted for 7,297 new HIV diagnoses
 in 2008, 17.7% of all new diagnoses for the year.2 Inner-city, sexually active adolescents
 are exceptionally vulnerable to contracting HIV and STIs.3 In 2008, the Bronx had the highest
 proportion of AIDS cases of any borough in New York City.5 For Bronx females aged 15 to 19,
 the CT infection case rate was 7,621 per 100,000 and 812 per 100,000 for GC, the highest in
 this age group in New York City.4 The infection rate among young men aged 15-19 in the Bronx
 is also the highest in New York City: the case rate was 2,092 for CT and 458 for GC.4

 Based on its concern about adolescent HIV risk, the CDC changed the HIV testing paradigm by
 recommending routine HIV testing for all adolescents. It also recommended routine HIV
 screening for all patients seeking STI testing and treatment at STI clinics.6 However,
 universal STI screening in adolescents is not routine in other medical settings, even though
 most STIs are asymptomatic and therefore undiagnosed. We believe that screening youth for HIV
 provides an opportunity to screen for STIs as well, and that testing should be combined with
 harm reduction interventions. This project will evaluate the efficacy of Project AWARE in
 diagnosing, treating, and preventing HIV and STI infections in a Bronx Emergency Department
 (ED).

 This proposal is based on eight years of research and experience developing and testing a
 successful ED-based multimedia program for HIV prevention.7 The first four years focused on
 developing videos that educated adult ED patients and encouraged them to be tested for HIV.
 Project BRIEF-A has achieved high acceptance (95%) for adult HIV testing and has linked 85%
 of HIV+ patients into specialized medical care.8,9 The last 4 years developed Project
 BRIEF-T, an efficient, youth-friendly, theory-based harm reduction video intervention for
 teens.10 It delivered different short video interventions to youth based on their stage of
 change. Results are promising: Project BRIEF-T was effective in moving youth to the next
 stage of change in their intentions to use condoms. We propose in this application to test
 Project AWARE, which will add universal STI testing to Project BRIEF-T, and evaluate the
 effects of the theory-based video intervention on condom use at 4, 8, and 12 months
 post-testing.

 Project AWARE will be evaluated using a three group randomized trial. Group 1, the control,
 will be the current standard of care, consenting video and testing for HIV alone (HIV-T).
 Group 2 will add routine STI testing for CT and GC, (STI/HIV-T). Group 3, in addition to
 combined STI/HIV testing, will add a behavioral video encouraging safer sex, which is chosen
 for participants based on their answers to a brief measure on stage of change (STI/HIV-PLUS).
 Comparing Group 1 to Group 2 will identify the number of new STI infections identified
 through routine testing to establish whether routine screening successfully identified a
 substantial number of new cases over and above routine care. Comparing Group 1 to Group 3
 will identify whether the addition of the Stages of Change intervention significantly
 increases condom use among teens.

 Specific Aims:

 1. To compare the efficacy of the three study arms and to test for significant differences
 at the 4 month follow up in order to provide information to programs concerning
 efficient use of resources.

 2. To study the persistence of the intervention effects over time between 4 and 12 months
 on the primary outcome as well as to examine the intervention effect on condom use
 intentions, condom self-efficacy, and condom outcome expectancy and reduce sexual risk
 behavior, at each follow up time point.

 3. To estimate the prevalence of STIs at baseline.

 The project is explicitly translational. If Project AWARE efficiently identifies and treats
 asymptomatic HIV and STIs, and successfully reduces subsequent sexual risk behavior among
 teens, it can be implemented in EDs at relatively low cost. Given the new emphasis in the
 U.S. on efficient preventive care, this project can provide an exemplary portable
 intervention tool that can reach many high risk youth with asymptomatic STIs and HIV who do
 not access routine primary care. The study's results might also contribute to the development
 of new screening policies to incorporate multiple STIs into existing HIV screening.
Inclusion Criteria:

 -  14-21 years old

 -  Sexually active

 -  English speaking

 Exclusion Criteria:

 -  medically unstable

 -  unable to understand the consent process

 -  tested for HIV/STI within the past 4 weeks