Study of Renal Blood Flow During Human Endotoxemia
Study of Renal Blood Flow During Human Endotoxemia
The purpose of the present protocol is to study whether endotoxemia will affect the renal
 blood flow in type 2 diabetics and healthy volunteers.
Many septic patients develop acute renal failure and the risk is higher in patients with
 diabetes. The pathogenetic mechanisms behind the development of acute renal failure in
 connection with sepsis is not completely understood. One among many possible explanations is
 a change in renal hemodynamics. However, it is still largely unknown what happens to the
 renal plasma flow during human sepsis. In this study we give endotoxin injection (0,3 ng/kg)
 to type 2 diabetics and healthy controls as an experimental model of sepsis. Renal plasma
 flow and glomerular filtration rate are measured by DTPA-renography 1 day before before and
 1,25 and 6,5 hours after injection of endotoxin. Furthermore WBC,
 plasma-cytokines,VCAM-1/ICAM-1, endothelin-1, Thromboxane B2, angiotensin 2, renin and PAI-1
 are measured on an hourly basis up to 8 hours after endotoxin injection.
Inclusion Criteria:

 -  Healthy

 -  Type 2 diabetes

 Exclusion Criteria:

 -  Renal failure

 -  Heart failure

 -  Lung disease