Fecal Microbiota Transplantation for Epilepsy
Fecal Microbiota Transplantation for Epilepsy
Increasing evidences showed the microbiota effects on neuropsychiatric disorders. This
 clinical trial aims to evaluate the efficacy and safety of fecal microbiota transplantation
 for epilepsy.
Very few literatures reported the clinical use of microbiota or bacteria for brain diseases.
 The most effective strategy for reconstruction of gut microbiota should be fecal microbiota
 transplantation (FMT). This study aims to evaluate the efficacy and safety of FMT for
 epilepsy. Patients were diagnosed as epilepsy by electroencephalogram (EEG) and MRI and
 clinical data when the study began and thent received repeated FMT with fecal from healthy
 donors.Patients were required to stop antiepileptic drugs after FMT and the follow up last
 for 3 months.The primary outcome measure was the frequency of the seizures. Secondary outcome
 measure were the 50% response rate.

 .
Inclusion Criteria:

 -  epilepsy diagnosed by typical electroencephalogram (EEG) and Magnetic resonance
 imaging (MRI)

 -  frequent relapses of epilepsy (> one seizure per 6 months) at a stabilize extent every
 year

 Exclusion Criteria:

 -  complicated with certain brain disease, including tumor,injury,cerebrovascular disease

 -  complicated with other severe disease, including cancers, organ failure, heart
 diseases

 -  Follow-up less than 6 months