Ig PRx in AECOPD: Pilot Study
Ig PRx in AECOPD: Pilot Study
This study will look at immunoglobulin (Ig) treatment in hospitalized chronic obstructive
 lung disease (COPD) patients with frequent exacerbations.

 This is a Phase II, pilot randomized double blind control study, meaning this study will help
 assess if this research can be expanded to evaluate Ig treatment in patients with COPD. Ig
 treatment is a sterile solution of human immunoglobulin proteins given intravenously (in the
 vein). Immunoglobulins are part of the immune system and help the body fight infections.
 Participants will be assigned to either receiving the Ig treatment or normal saline as a
 control product every 4 weeks for 12 months.

 Participants will continue on current standard therapy as determined by their treating
 physician.
Inclusion Criteria:

 -  Hospitalized adult patient with AECOPD (clinically dominant AECOPD in the case of
 multiple co-morbidities eg. absence of overt lobar pneumonia or acute congestive heart
 failure or alternate diagnosis such as acute coronary syndrome or pulmonary embolism)

 -  Diagnosis of severe COPD (post bronchodilator FEV1 <50%, FEV1/FVC ratio <0.7) made by
 standard spirometry within previous 12 months or within three days of admission if
 previous PFT data is not available

 -  Age >40 years

 -  >10 pack year smoking history

 -  At least one COPD exacerbation in the previous 12 months before enrollment, defined by
 having had documented inpatient or outpatient treatment by physician with antibiotics
 and/or prednisone for physician diagnosed COPD exacerbation

 -  Expected to live > 12 months

 Exclusion Criteria:

 -  Known severe hypersensitivity to immunoglobulin or its components (anaphylaxis)

 -  Underlying malignancy (including chronic lymphocytic leukemia)

 -  History of hematopoietic stem cell transplant or solid organ transplant

 -  Current treatment with a biological therapy for other conditions

 -  Concomitant significant immunodeficiency or on immunosuppressive treatment other than
 for COPD

 -  Alpha-1 antitrypsin deficiency

 -  Significant proteinuria (dipstick proteinuria ≥ 3+ or known urinary protein loss ≥ 2
 g/day or nephrotic syndrome) and/or has acute renal failure and/or severe renal
 impairment (creatinine more than 2.5 times the upper limit of normal and/or on
 dialysis)

 -  IgA deficiency (IgA <0.1 g/L)

 -  Immunoglobulin therapy in the last 12 months or on current Ig therapy or have a
 clinical indication for Ig replacement therapy
 (www.nacblood.ca/resources/guidelines/IVIG.html)

 -  Obesity (BMI ≥35 kg/m²)

 -  Pregnancy