Endothelial Function in Patients With Sickle Cell Anemia Before and After Sildenafil
Endothelial Function in Patients With Sickle Cell Anemia Before and After Sildenafil
The investigators would like to study the endothelial function in sickle cell patients
 without pulmonary hypertension in an in vivo method during a steady state condition before
 and after sildenafil treatment for 1 month, and to study the effects of this nitric oxide
 donor by measuring the Flow Mediated Dilatation, by measuring endothelial progenitor stem
 cells colonies, and by measuring the effect of therapy on markers of inflammation (cell
 adhesion molecules and cytokines).
Inclusion Criteria:

 -  patients with sickle cell anemia

 Exclusion Criteria:

 -  patients with sickle cell anemia during acute crisis