Hepatitis C Virus (HCV) Positive Liver Grafts in HCV Negative Recipients
Hepatitis C Virus (HCV) Positive Liver Grafts in HCV Negative Recipients
To provide proof-of-concept data on the efficacy/safety of transplanting HCV positive donor
 grafts in HCV sero-negative liver recipients who are currently listed.
Inclusion Criteria:

 -  Male or female

 -  Age 18 and older

 -  Active on the transplant list

 -  Donor organ with Antibody and nucleic acid test (NAT) positive for HCV

 -  Graft with F2 fibrosis or less at time of explant

 -  HCV negative recipient; this includes patients who never had HCV and those with HCV
 previously eradicated with antiviral therapy. The latter is defined as those with
 undetectable HCV viral load at least 3 months since stopping therapy.

 -  Willing and able to provide written informed consent or for those subjects where
 hepatic encephalopathy affects their ability to provide initial or ongoing consent,
 has an appropriate and legally-authorized representative willing and able to provide
 consent on behalf of the subject

 Exclusion Criteria:

 -  Participants co-infected with HIV

 -  Donor previously treated with a non-structural protein 5A (NS5a) containing regimen
 (if treatment history of donor known)

 -  Known allergies or hypersensitivity to direct acting antiviral drug (DAA) or ribavirin
 (RBV)

 -  Pregnancy and/or actively breastfeeding