The Factors Associated With the Recurrence in Patients With Cushing Disease
The Factors Associated With the Recurrence in Patients With Cushing Disease
Cushing syndrome refers the manifestations induced by chronic glucocorticoid excess and may
 arise from various causes. Iatrogenic Cushing syndrome accounts for most patients, when they
 are given exogenous glucocorticoid treatment. In contrast, spontaneous Cushing syndrome
 results from endogenous glucocorticoid over-secretion. Although Cushing disease is rare, it
 is the most common cause of spontaneous Cushing syndrome. The patient with Cushing disease
 has a pituitary corticotroph adenoma, which overproduces adrenocorticotropic hormone (ACTH).
 ACTH then stimulates adrenal gland to over-secret glucocorticoid. Patients with untreated
 Cushing disease were shown to have poor prognosis, estimated a 5-year survival rate of 50%.
 The first line treatment is tumor resection. Other managements include radiotherapy,
 medication and bilateral adrenalectomy. The initial remission rate is high (66-90%). However,
 some patients encounter with disease recurrence during follow-up.

 The aim of this study is to clarify the factors associated with the recurrence after
 treatment. In this study, we will review the patients with Cushing disease thoroughly and
 analyze associated predisposing factors. These risk factors can remind the clinical physician
 to early detect the recurrent disease in these patients, and further prevent morbidity and
 mortality in their later lives.
Inclusion Criteria:

 -  Clinical diagnosed Cushing's disease

 Exclusion Criteria:

 -  Already received treatment in other hospital

 -  Ectopic Cushing's syndrome