Evaluation of the Benefit of the Training of the Manual Dexterity Post Stroke.
Evaluation of the Benefit of the Training of the Manual Dexterity Post Stroke.
Stroke is the second leading cause of death and disability in France: more than half of
 stroke survivors have a disabling motor deficit, affecting mainly the upper limb. A lack of
 hand control makes everyday tasks more difficult and reduces the quality of life. The
 investigators lack approaches to specifically rehabilitate the hand after stroke.

 Recently, a new tool has been developed to measure manual dexterity (the Finger Force
 Manipulandum or FFM). This tool, which records the forces applied by the fingers on pistons,
 allows to measure more finely the key components of manual dexterity during visuomotor tasks.
 The tool measures the ability to control and release the force applied by the fingers, to
 perform sequences, to track and maintain a frequency of tapping (temporality of movement)
 with the fingers, and to use the fingers independently one another.
The DexTrain proof-of-concept study aims to evaluate the benefit of a training using a tool,
 an improved version of the FFM, named DexTrain, for the rehabilitation and specific training
 of the fingers in subjects suffering from stroke. In this study the investigators will
 compare the effect of conventional therapy with that of the DexTrain method, particularly on
 the function of the hand and its spontaneous use at home (ecological condition). To better
 understand the mechanisms involved, the investigators will also study brain plasticity using
 Transcranial Magnetic Stimulation (SMT) and Functional Magnetic Resonance Imaging (fMRI).
Inclusion Criteria:

 Patient :

 -  At least 18 years old

 -  1st symptomatic stroke, due to acute vascular injury (ischemic or haemorrhagic)
 affecting a single arterial territory dating from 3 months or more (multiple
 territory: corresponds to a bi-hemispheric or vertebrobasilar stroke and carotid for
 ischemic and bi-hemispherical stroke for hemorrhagic stroke)

 -  With a slight-to-moderate deficit of manual dexterity, indicated by a difficulty in
 picking up blocks in the Box and Block test (<52 blocks / minute, minimum 1 block) as
 well as an expansion capacity of 10 ° wrist and metacarpophalangeal joints of the
 index and middle finger.

 -  Affiliated to a social security scheme, Universal Health Cover or any other equivalent
 plan.

 Volunteers :

 -  At least 18 years old

 -  Healthy subject of any disease affecting the hand,

 Exclusion Criteria:

 -  Significant disability or pre-existing deficiency that may interfere with
 study-specific assessments:

 • History of symptomatic stroke

 -  Disorders of the understanding not allowing a good comprehension of the tests of motor
 skills (severe aphasia, dementia, etc.) evaluated by the MMSE (<25)

 -  Botulinum toxin treatment of spastic muscles of the upper limb less than three months
 before inclusion and / or during rehabilitation (4 weeks).

 -  Another severe disease making follow-up difficult.