Early Detection of Atherosclerosis: a Randomized Trial in the Primary Prevention of Cardiovascular Diseases.
Early Detection of Atherosclerosis: a Randomized Trial in the Primary Prevention of Cardiovascular Diseases.
The incidence of cardiovascular diseases is still high and further efforts should be done in
 primary prevention. The main objective is to quantify the burden of subclinical
 atherosclerosis using non-invasive techniques,and to study the impact of this assessment and
 consequent treatment in the progression of atherosclerosis and in the incidence of
 cardiovascular diseases.
We will perform non-invasive techniques (carotid Intima-Media Thickness, CAC score and
 ankle-brachial index) to individuals at intermediate cardiovascular risk.With these results,
 we will classify participants in: no atherosclerosis, mild, moderate and severe
 atherosclerosis, and therapeutic targets will be set according to pre-defined algorithms. The
 end-point will be the course of atherosclerosis measured by cIMT/CAC score (2 years) and the
 incidence of CVD at 5 years of follow-up.
Inclusion Criteria

 One or more of the following:

 -  Familiar History of early-onset cardiovascular disease (male < 55 or female < 65).

 -  Type 2 Diabetes mellitus or type 1 with microalbuminuria.

 -  Essential High Blood Pressure.

 -  Chronic Kidney Disease.

 -  Primary hyperlipidemia.

 The presence of two or more of the following:

 -  Current smoker.

 -  Physical inactivity.

 -  High blood pressure (recently diagnosed).

 -  Abdominal perimeter: > 102 cm. males; > 88 cm. females.

 -  Total cholesterol > 240 mg/dL.

 -  HDL cholesterol ≤ 40 mg/dL males, ≤ 50 mg/dL females.

 Exclusion Criteria:

 -  Age < 40 or > 74 years old.

 -  Previous Cardiovascular Event.