Study to Evaluate the Safety and Efficacy of Seasonale for Treatment of Low Bone Mineral Density
Study to Evaluate the Safety and Efficacy of Seasonale for Treatment of Low Bone Mineral Density
This is a randomized, multicenter, placebo-controlled study to evaluate the effects of
 Seasonale, an extended-regimen oral contraceptive, on bone mineral density in adolescent
 females who have had their menstrual period but now have secondary amenorrhea and also have
 osteopenia. The duration of the study for each patient will be approximately two years.
Inclusion Criteria:

 -  Not sexually active and agree to remain sexually inactive throughout the course of the
 study

 -  First menstrual period at least one year ago

 -  No menstrual period in the last 6 months

 Exclusion Criteria:

 -  Undiagnosed abnormal genital bleeding

 -  Known or suspected pregnancy

 -  Medical history of any disorder that contraindicates the use of oral contraceptives