Abdominal Binding in Chronic Obstructive Pulmonary Disease
Abdominal Binding in Chronic Obstructive Pulmonary Disease
Conventional approaches to relieve dyspnea (respiratory discomfort) in chronic obstructive
 pulmonary disease (COPD) have focused on improving respiratory motor drive (e.g., hyperoxia)
 and/or dynamic respiratory mechanics (e.g., bronchodilators). Although these approaches yield
 meaningful symptom improvements there remains many COPD patients incapacitated by dyspnea.
 Accumulating evidence suggests that abdominal binding (AB) is a potentially novel method of
 improving respiratory muscle function and, by extension, dyspnea and exercise tolerance in
 COPD. Thus, the purpose of this randomized, cross-over study is to test the hypothesis that
 AB improves exertional dyspnea and exercise tolerance in symptomatic patients with COPD by
 improving dynamic respiratory muscle function. To this end, the investigators will examine
 the effects of AB on detailed assessments of baseline pulmonary function (spirometry,
 plethysmography), dyspnea (sensory intensity & affective responses), neural respiratory drive
 (diaphragm EMG), contractile respiratory muscle function (esophageal, gastric &
 transdiaphragmatic pressures), ventilation, breathing pattern and cardiometabolic function
 during symptom-limited constant load cycle exercise (75% Wmax) in 20 patients with GOLD stage
 II/III COPD.
Inclusion Criteria:

 -  Male or Female

 -  Aged ≥40 years

 -  Ambulatory

 -  Cigarette smoking history ≥15 pack years

 -  No change in medication dosage or frequency of administration, with no exacerbations
 or hospitalization in the preceding 6 weeks.

 -  Post-bronchodilator Forced Expiratory Volume in 1 second between 30-80% predicted

 -  Post-bronchodilator Forced Expiratory Volume in 1 second/forced vital capacity ratio
 of <70%

 Exclusion Criteria:

 -  Presence of active cardiopulmonary disease other than COPD

 -  Use of domiciliary oxygen

 -  Exercise-induced arterial blood oxyhemoglobin desaturation to <80% on room air.

 -  Body Mass Index <18.5 or ≥35 kg/m2.

 -  Allergy to latex

 -  Allergy to lidocaine or its "caine" derivates.