Evaluation of Histamine H3 Receptor Radioligand [11C]AZ12807110 and Histamine H3 Receptor Occupancy of AZD5213 After Oral Administration
Evaluation of Histamine H3 Receptor Radioligand [11C]AZ12807110 and Histamine H3 Receptor Occupancy of AZD5213 After Oral Administration
The purpose of this study is to investigate features of radioligand [11C]AZ12807110 and how
 much AZD5213 displaces radioligand from histamine receptors when given together.
Inclusion Criteria:

 -  Healthy male and/or female volunteers between 20 to 45 years with suitable veins for
 cannulation or repeated venipuncture (pilot panel)

 -  Female must be of non-child bearing potential (pilot panel)

 -  BMI between 18 to 30 30 kg/m2

 -  Normal MRI scan

 -  Provision of signed, written and dated informed consent

 Exclusion Criteria:

 -  History of any clinically significant disease or disorder

 -  History or presence of gastrointestinal, hepatic or renal disease

 -  Prolonged QTcF >450 ms or shortened QTcF <340 ms or family history of long QT syndrome

 -  History of severe allergy or hypersensitivity or ongoing allergy or hypersensitivity

 -  Healthy volunteer suffers from claustrophobia