Aortic Calcification - is it a Marker for Carotid Artery Stenosis?
Aortic Calcification - is it a Marker for Carotid Artery Stenosis?
Atherosclerosis is the major contributor for the morbidity and mortality for the variety of
 cardiovascular diseases.

 Aortic calcification on x-ray is a marker for arterial atherosclerosis and an independent
 prognostic factor for the morbidity and mortality from a cardiovascular event.

 Carotid artery stenoses is the current accepted indication for interventional treatment of
 carotid artery, for the prevention of embolic event, while other arterial atherosclerosis
 indication, is for hemodynamic disturbance and ischemic outcome.

 This research will try to find whether incidental aortic calcification can predict carotid
 artery stenosis.

 Two groups will be chosen: group A - patients who had CT scan in the hospital (for different
 indications); Group B - patients (not from the first group) who have a significant carotid
 artery stenosis who are indicated for interventional treatment.

 The data to analyze:

 Group A - Patients with aortic calcification, carotid artery stenosis, and patients with both
 Group B - Patients who have aortic calcification Comparison of the populations within the
 group and among the two will show if a significant correlation between aortic calcification
 and carotid artery stenosis exist.
Background - thoracic or abdominal aortic calcification is a documented independent risk
 factor for cardiovascular atherosclerotic disease and increased death.

 Atherosclerosis is a diffuse multicentric disease in the arterial tree, affecting target
 organs (heart, aorta, lower extremities, carotid arteries etc.). Mostly located in arterial
 bifurcations (Iliac and carotid artery bifurcations) or in constant repetitive arterial
 trauma (Adductors tendon, Hunter's canal). The invasive treatment (endovascular, surgery) is
 preserved for patients with critical arterial stenosis or occlusion in symptomatic patients.
 Exceptions are the carotid arteries: the majority of patients with a severe internal carotid
 artery stenosis are asymptomatic patients, which are treated for the prevention embolic
 events (TIA's or CVA's).

 Current articles are observational, and describe retrospectively the morbidity and mortality
 from atherosclerosis with aortic calcification.

 the investigators assumption is that if aortic calcification is a marker for diffuse
 atherosclerosis, it has good correlation to criptogenous carotid artery disease, and can lead
 to early carotid artery disease evaluation and treatment.

 Purpose - to find a reliable correlation between aortic calcification, and carotid artery
 stenosis (from atherosclerosis)

 Method - two groups will be evaluated:

 Group A - patients (age >40 years), that had a CT scan (chest/abdomen) for any indication,
 will be evaluated for aortic calcifications. The patients will be additionally examined for
 carotid artery stenosis by Doppler ultrasound. (100 patients) Group B - Patients that were
 diagnosed by Doppler ultrasound, and were found to have a severe carotid artery stenosis.
 These patients are scheduled for a computed tomography-angiography (regardless for the
 research) of the cervical arteries, will be additionally complete abdominal/chest tomography
 scan, without additional contrast. (50 patients).

 Results - will be statistically evaluated - Group A - number of patients with aortic
 calcification, number of patients with carotid artery stenosis; Group B - Number of patients
 that have associated aortic calcification.
Inclusion Criteria:

 Group A - patients, age 40-99 years, that had a CT scan for any indication Group B -
 patients with severe carotid artery stenosis, that indicated for treatment

 Exclusion Criteria:

 -  Group A - age <40 years

 -  Group B - carotid artery stenosis, without intention-to-treat