Molecular Imaging of Inflammation With 18F-PBR06 to Identify Unstable Carotid Plaques in Patients With Stroke
Molecular Imaging of Inflammation With 18F-PBR06 to Identify Unstable Carotid Plaques in Patients With Stroke
Evaluating an innovative molecular imaging technique to visualize inflammation of the
 atherosclerotic plaque in patients with a recent ischemic stroke (<15 days) with carotid
 stenosis> 50%, by performing a Positron emission tomography-computed tomography (PET-CT) with
 PBR06 18F, a tracer for Translocator protein (TPSO).
More than one third of cerebral ischemic events are related to an atheromatous plaque.
 Inflammation, through a key player, the macrophage, is associated with increased metabolic
 activity of atherosclerotic plaque and its possible rupture. Inflammation within the plate is
 thus a marker of instability. These data underscore the importance of a prospective
 evaluation of inflammation with specific imaging with PET tracers inflammation.
Inclusion Criteria:

 -  Man with transient ischemic attack or recent ischemic stroke (<15j) in the carotid
 territory, confirmed by MRI

 -  Man with carotid stenosis> 50% on the side of stroke

 -  Male candidate for carotid endarterectomy

 -  Subject affiliated or beneficiary of a social security scheme

 -  Informed written consent

 Exclusion Criteria:

 -  Women

 -  Chronic inflammatory disease in progress (cancer, vasculitis, ...)

 -  Patient with infection within 7 days

 -  A person placed under judicial protection, guardianship

 -  Incapable of giving consent

 -  Low affinity binder for TSPO