Correction of Vitamin D Deficiency and Its Effect on Ovulation Induction in Women With PCOS (VIDEO): A Feasibility RCT
Correction of Vitamin D Deficiency and Its Effect on Ovulation Induction in Women With PCOS (VIDEO): A Feasibility RCT
Recently, a special emphasis has recently been directed to the potential role of vitamin D
 and some regulatory peptides (e.g. adipokines and follistatin) and their associated metabolic
 roles and genetic factors in the development of PCOS and its related co-morbidities. The aim
 of this study was to assess the feasibility of conducting a pragmatic RCT assessing the
 effectiveness of adopting a protocol of screening for and correcting Vitamin D deficiency in
 women with PCOS seeking fertility treatment in a low/middle income care (LMIC) setting
Research question:

 In PCOS patients, is there any effect of vitamin D testing and correction on ovulation
 induction in women with PCOS?

 Research hypothesis:

 There is effect of testing and correcting vitamin D status as regard ovulation in patients
 with PCOS
Inclusion Criteria:

 -  diagnosed PCOS cases according to the National Institute of Health criteria (NIH
 consensus criteria) and Rotterdam criteria

 Exclusion Criteria:

 -  1- PCOS patients not in child bearing age; less than 18 years or more than 45 years.

 2- Patients with congenital adrenal hyperplasia, androgen-secreting tumors, Cushing's
 syndrome, hyperprolactinemia and virilizing ovarian or adrenal tumors.

 3- PCOS patients with any other medical illness. 4- PCOS patients already on vitamin D
 supplements.