Sequential Changes of Serum KL-6 Predict Progression in Interstitial Lung Disease
Sequential Changes of Serum KL-6 Predict Progression in Interstitial Lung Disease
Interstitial lung disease is a chronic progressive fibrosis lung disease that with a highly
 variable clinical process.thence it is significant for the patient to search a convenient and
 accurate prediction method. The objective of this study was to determine whether peripheral
 blood biomarkers can predict disease .
The median follow-up period was 12 months, each patient received 4 or 5 follow-ups in our
 center, 336 person-times in study enrollment totally. The patients with interstitial lung
 disease had significantly higher serum baseline KL-6 and MMP-7 levels compared with healthy
 control.They divided into progressive group and non-progressive group according to disease
 change. Serum KL-6 and MMP-7 levels were elevated in patients if disease progression, but
 baseline level of biomarkers in progressive group were not significant higher compare with
 non-progressive group .Binary logistic regression showed △KL-6 and △MMP-7 were significant
 predictors for disease progression. Multivariate Cox analysis showed KL-6 and MMP-7 were
 significantly associated with survival along with other variables.

 The serum levels of KL-6 and MMP-7 were elevated in the individuals with interstitial lung
 disease compared with healthy controls. The rate of poor prognosis and mortality more
 associated with the variability increased biomarker concentrations，rather than the baseline
 concentration.Therefore，Serial measurements of biomarkers contribute to the disease
 monitoring in clinical management.
Inclusion Criteriar:

 -  Clinical diagnosis of interstitial lung disease

 Exclusion Criteria:

 -  Diagnosise of interstitial lung disease acute excerbation

 -  Combined pulmonary embolism, pulmonary edema, pulmonary tuberculosis, and peumonias