The Effects of T4 Versus T4/T3 on Psychological Distress After Total Thyroidectomy in Thyroid Cancer Patients
The Effects of T4 Versus T4/T3 on Psychological Distress After Total Thyroidectomy in Thyroid Cancer Patients
The goal of this research is to compare the effects on psychological distress between T4 mono
 replacement group and T4/T3 combination replacement group after total thyroidectomy in
 thyroid cancer patients.

 1. Subjects:

 -  Psychologically distressed patients, such as depression, anxiety, and fatigue
 patient after total thyroidectomy with thyroid cancer are considered for
 participation. Screening of distress after total thyroidectomy is used HADS
 (Hospital Anxiety and Depression Scale) ≥ 8 for depression or anxiety, and MDASI-F
 (MD Anderson Symptom Inventory -Fatigue) ≥ 4 for fatigue.

 2. Randomization:

 -  Using the table of random sampling numbers, patients assign to T4 mono replacement
 group or T4/T3 combination replacement group.

 3. Evaluation for distress:

 -  Assessment will be made baseline, 4 weeks, 12 weeks and 24 weeks to investigate
 change of psychological distress (depression, anxiety, and fatigue). Level of
 distress after thyroidectomy will determine using Hospital Anxiety and Depression
 Scale (HADS), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI) for
 depression or anxiety, and Brief Fatigue Inventory (BFI) for fatigue.
Inclusion Criteria:

 1. Patient who need thyroid hormone replacement therapy after total thyroidectomy for
 thyroid cancer

 2. HADS (Hospital Anxiety and Depression Scale) ≥ 8 for depression or anxiety, or MDASI-F
 (MD Anderson Symptom Inventory -Fatigue) ≥ 4

 3. Patient who maintain TSH recommendation range for TSH suppression according to ATA
 guidelines

 Exclusion Criteria:

 1. < 19 or ≥ 70 years old

 2. Communication difficulties or inability to complete the necessary investigations and
 questionnaires

 3. Inability to understand purpose of the study or disagree of participation

 4. Past history of psychiatric treatment or diagnosis

 5. Lactation or pregnancy

 6. Past medical history of other cancer diagnosis or treatment

 7. Any of severe comorbid medical conditions according to ASA score ≥ 3