Development of a New Diagnosis and Intervention Method for Developmental Disorders
Development of a New Diagnosis and Intervention Method for Developmental Disorders
The purpose of this study is to develop a new diagnostic method for developmental disorders
 based on behavior recording during the interview of the subjects by medical staff as well
 anonymous persons. The behavior recording by video camera will be accompanied by non-invasive
 physiological recordings, including electroencephalogram (EEG), electrocardiogram (ECG),
 electromyogram (EMG), and body temperature using infrared (IR) thermograph. Thus, the
 physiologically relevant and the disorder correlated behavior parameters could be extracted
 and used as new diagnostic markers. If necessary, the medical staff may take blood sample
 from the subject before and after the interview. For the longitudinal study, the similar
 interview and the recording of the same subject will be planned to evaluate the effect of the
 medical and educational intervention. The investigators also examine the synergistic effect
 of the intervention and the administration of the supplement (e.g., vitamin D, arachidonic
 acid, coenzyme Q10 (CoQ-10)). The clinician may use Risperidone.
Case 1:The investigators started the intervention and supplementation of arachidonic acid for
 3 patients diagnosed as autistic spectrum disorders (ASD) from September 4, 2010 at Sawa
 hospital (Osaka, Japan). Another ASD patients (n=5) at Sawa hospital were treated by
 administration of Risperidone as medicinal drink from January 14, 2011. The supplementation
 as well as Risperidone administration followed double-blind placebo controlled cross-over
 protocol to access the effect of the treatment. These trials will continue until November
 2011. Final outcome will be evaluated by clinical diagnosis and behavior parameters
 measurement as described under Brief Summary.

 Case 2: The investigators started the intervention and supplementation of reduced form of
 CoQ10 for learning disability children (n=20) at small private cramming school (JIZAI-ken,
 Tokyo) from February 5, 2011. This trial will continue until October 2011. The effect of the
 intervention and supplementation will be evaluated by behavior parameter measurement as
 described above.
Inclusion Criteria:

 -  Developmental disorders

 Exclusion Criteria:

 -  Mental retardation