Efficacy and Mechanism of Action of Methenamine Hippurate (Hiprex™) in Women With Recurring Urinary Tract Infections.
Efficacy and Mechanism of Action of Methenamine Hippurate (Hiprex™) in Women With Recurring Urinary Tract Infections.
The purpose of this study is to measure the concentration of formaldehyde in the urine of
 women with recurrent urinary tract infections on Hiprex; and then, assuming its urinary
 presence is confirmed at the proper acid urinary pH, evaluate if such a therapy has favorable
 effects in decreasing the rate of recurrent urinary tract infections over time.
Inclusion Criteria:

 1. Female

 2. Age 50 - 85

 3. Have RUTIs (at least 2 UTIs within the past 6 months or 3 within the past year) -

 Exclusion Criteria:

 1. Being on antibiotics at baseline (i.e. suppressive therapy or antibiotic therapy for
 urinary or non-urinary infections)

 2. Neurogenic bladder condition

 3. Using urinary catheters (including Foley catheter, intermittent catheterization, and
 suprapubic catheter)

 4. Uncontrolled diabetes (HbA1c > 9)

 5. Chronic renal failure defined as serum creatinine > 1.5 mg/dL

 6. History of liver disease

 7. Patients from out of town, in whom follow-up will not be possible

 8. Pregnancy

 9. Allergy to Hiprex

 10. Inability to take Hiprex reliably at home, such as having psychosis, dementia, or
 swallowing disorders

 11. Non-English speakers -