Effect of Probiotic on Depression
Effect of Probiotic on Depression
Depressive disorder, also known as depression, is a type of mood disorder characterized by
 persistent low mood. The incidence of depression worldwide is about 6%. Growing evidence
 suggested that the gut microbiota plays a key role in the development of depression.
 Probiotics can effectively regulate gut microbiota, and showed potential in alleviating
 depression. This study investigated the effect of formula probiotic (containing Lactobacillus
 paracasei, Bifidobacterium animalis, Bifidobacterium longum, Bifidobacterium bifidum and
 Lactobacillus plantarum) on depression.
Inclusion Criteria:

 -  Normal body mass index ≥ 18.5 until ≤ 29.9

 -  Mild to moderate major depression diagnosed by psychiatrists according to the
 diagnostic criteria for depressive episodes in DSM-5 (American Diagnostic and
 Statistical Manual of Mental Disorders (Fifth Edition))

 -  Hamilton Rating Scale for Depression (HAMD-17) score not less than 8

 -  Agreed to intake study product during the study period

 -  Agreed to sign written informed consent

 Exclusion Criteria:

 -  Use of systemic antibiotics or antimycotics medication in the 30 days prior to the
 study

 -  Investigator's uncertainty about the willingness or ability of subject to comply with
 the protocol requirements

 -  Persons with a milk protein allergy, lactose intolerance

 -  Pregnant or breastfeeding women

 -  Subject had other serious diseases