Effect of Preoperative Steroid in Total Knee Arthroplasty
Effect of Preoperative Steroid in Total Knee Arthroplasty
Detect the effect of preoperative steroid injection in total knee arthroplasty on post
 operative:

 1. pain

 2. oedema

 3. nausea and vomiting

 4. quadriceps power

 5. knee flexion

 6. wound complications
Total knee arthroplasty has been identified as one of the most effective surgeries for knee
 arthritis. Many patients experience moderate to severe pain during the early postoperative
 period, as the surgery involves extensive bone resection and postsurgical serum levels of
 cytokine interleukin-6 and C-reactive protein may be elevated.Furthermore, many patients
 suffer postoperative nausea and vomiting after total knee arthroplasty . The inflammatory
 response after TKA is pronounced and a result of cumulative effects of anaesthesia and
 mechanical stress . Inadequate management of postoperative pain is relevant with a series of
 undesirable effects, including progression to a persistent pain, delayed functional recovery,
 increased the economic burden and patient dissatisfaction. Steroids may be associated with
 decreased levels of interleukin-6 and C reactive protein and may, thus, relieve the pain
 associated with surgery. Dexamethasone is a long-acting glucocorticoid that has been reported
 to inhibit peripheral phospholipase A, which decreases the pain-aggravating agents from the
 cyclooxygenase and lipoxygenase pathways . In addition, it reduces postoperative nausea and
 vomiting by exerting a central antiemetic effect by inhibiting prostaglandin synthesis and
 the release of endogenous opioids[5] . Some studies also reported potential adverse events,
 such as infection .
Inclusion Criteria:

 1. Any patient scheduled for primary total knee replacement arthroplasty

 Exclusion Criteria:

 1. Diabetic patients

 2. Rheumatoid arthritis patients

 3. Patients on regular steroid therapy

 4. Patients refused to be enrolled in the study