Pyridostigmine and Its Effects on Autonomic Modulation in Diabetic Patients
Pyridostigmine and Its Effects on Autonomic Modulation in Diabetic Patients
The purpose of the study is to determine if pyridostigmine bromide improves heart rate
 variability of type 2 diabetes mellitus subjects with cardiovascular autonomic neuropathy.
The reduced heart rate variability is associated with increased risk of death in patients
 with diabetes mellitus. Cholinesterase inhibition with pyridostigmine bromide increases heart
 rate variability in normal individuals and congestive heart failure subjects but its effects
 on patients with diabetes mellitus is unknown. Based on those evidences, we will test if the
 short-term administration of pyridostigmine bromide increases heart rate variability in
 patients with diabetes mellitus.
Inclusion Criteria:

 -  diabetes mellitus

 Exclusion Criteria:

 -  myocardial infarction

 -  acute ischemic syndromes

 -  second or third degree atrioventricular block

 -  active alcoholism

 -  thyroid dysfunction

 -  chronic obstructive pulmonary disease

 -  history of intolerance to pyridostigmine.