Insulin Resistance in Patients With Major Depression
Insulin Resistance in Patients With Major Depression
The purpose of this study is to study the relationship between insulin and glucose action and
 neuropsychological functioning (memory, attention, general thinking abilities) in persons
 with depression.
Inclusion Criteria:1)Willingness to sign the Human Subject Protection Consent Form prior to
 enrollment into the study.

 2)Men and women ages 20 to 65 years of age. 3)Diagnosis of unipolar, non-psychotic,
 non-melancholic major depressive disorder (MDD) or depressive episode of bipolar disorder
 (Bipolar I, II or NOS), based on a Structured Clinical Interview for DSM-IV Axis I
 disorders (SCID) and confirmed by a psychiatrist.

 4) Depression severity as defined by score of <17 on the 21-item Hamilton Rating Scale for
 Depression and no psychiatric admission within 6 months from study entry and no suicide
 attempt within the last 12 months.

 5)Adequate visual and auditory acuity to allow neuropsychological testing. 6)Stable regime
 of psychiatric medications for 1 month prior to insulin test. Exclusion
 Criteria:1)Diagnosis of possible or probable cognitive impairment.

 2)For women only: pregnancy, breastfeeding. 3)Personal history of Type I or Type II
 diabetes. 4) Unstable cardiovascular disease or other major medical condition, or history
 of myocardial infarction within the previous year.

 5)Significant cerebrovascular disease, as evidenced by neurological examination,
 uncontrolled hypertension (systolic blood pressure > 170 or diastolic blood pressures >
 100).

 6) Current drug or alcohol abuse. 7)History of neurological disorder, e.g. multiple
 sclerosis, stroke etc. 8)Use of any drug that may significantly affect psychometric
 testing, or the insulin testing