Sudden Hearing Loss Multi-center Clinical Trial
Sudden Hearing Loss Multi-center Clinical Trial
The incidence of sudden hearing loss is rising obviously resent year, Glucocorticoids have
 obtained obvious effect in the treatment of sudden deafness. Postauricular hypodermic
 injection is the latest findings in clinical work and a new noninvasive way of administration
 which is gradually expanding research. The aim of this experiment is to verify and explore
 the efficacy and safety of the postauricular injection treatment with different doses of
 Glucocorticoids.
Inclusion Criteria:

 -  Older than 18 years, less than 60 years old;

 -  patient with unilateral or bilateral（occured successively) acute sensorineural hearing
 loss(ASNHL) with onset 72hours or less ago. Mean hearing loss compared with the
 unaffected contralateral ear of at leat 60 dB;

 -  Primary presentation within 2weeks; standard treatment for 2 weeks;

 -  After 2weeks of standard treatment, sensorineural hearing loss (SHL) curative effect
 evaluation damaged frequencies >/=30 dB better than before;

 -  Written informed consent before participation in the study.

 Exclusion Criteria:

 SYSTEMIC DISEASE

 -  History of tuberculosis or positive purified protein derivative (PPD);

 -  Insulin-dependent diabetes mellitus;

 -  Hypertension, poor control of BP(SBP/DBP)>=140mmHg);

 -  History of rheumatic disease, e.g. rheumatoid arthritis, scleroderma, lupus, etc;

 -  Serious psychiatric disease or psychiatric reaction to corticosteroids;

 -  History of heart disease or transient ischemic attacks(TIAs);

 -  Prior treatment with chemotherapeutic or immunosuppressive drugs;

 -  Pancreatitis;

 -  Active peptic ulcer disease or history of gastrointestinal bleeding;

 -  History of HIV, Hepatitis B or C;

 -  Chronic kidney failure;

 -  Alcohol abuse;

 -  Active shingles;

 -  Severe osteoporosis or non-surgical aseptic necrosis of the hip;

 -  Without contraindication with glucocorticoid, ginaton, Batroxobin.

 OTOLOGIC DISEASE

 -  History of Meniere's disease;

 -  History of chronic ear infection;

 -  Prior history of sudden sensorineural hearing loss (SSNHL);

 -  History of fluctuating hearing loss.