Prospective Cohort Study of the Effect of Bariatric/Metabolic Surgery on Morbid Obesity Patients With Metabolic Syndrome
Prospective Cohort Study of the Effect of Bariatric/Metabolic Surgery on Morbid Obesity Patients With Metabolic Syndrome
The purpose of this study is to determine the change in kidney function and blood pressure
 after gastric bypass versus conventional medical therapy in morbid obesity. The study mainly
 focus on glomerular filtration rate(GFR) with known relation to the renal function and 24
 hours ambulatory blood pressure monitoring after intervention of gastric bypass or medical
 treatment.
Metabolic syndrome is strongly associated with obesity and the patients with this syndrome
 are at increased risk for cardiovascular disease.

 Obesity constitutes a strong risk factor for the development of chronic kidney disease. Among
 diabetics, obesity is known to amplify the risk for kidney disease.

 Bariatric surgery has yielded dramatic results including longitudinal loss of excess body
 weight and either complete reversal or significant improvement of several features of
 metabolic syndrome. In addition, many observational studies have demonstrated significant
 reduction in proteinuria after bariatric surgery.

 However, the changes in the component of cardiovascular problem among metabolic syndrome and
 changes in renal filtration function or progression to end stage kidney disease in morbidly
 obese patients after weight loss surgery have not been extensively studied. Therefore, our
 study mainly focus on glomerular filtration rate(GFR) with known relation to the renal
 function and 24 hours ambulatory blood pressure monitoring after intervention of gastric
 bypass or medical treatment.
Inclusion Criteria:

 -  Morbid obesity (BMI>30) patients with one of comorbidity (type 2 diabetes,
 dyslipidemia, or hypertension)

 -  Morbid obese patients (BMI>35)

 Exclusion Criteria:

 -  Prior bariatric surgery

 -  Malignancy (any type)

 -  End stage renal disease