Preovulatory Uterine Flushing With Saline as a Treatment for Unexplained Infertility
Preovulatory Uterine Flushing With Saline as a Treatment for Unexplained Infertility
The purpose of this study is to determine whether preovulatory uterine flushing with
 physiological saline is effective in the treatment of unexplained infertility.
In vitro fertilisation is the only current reasonable treatment for unexplained infertility.
 Uterine flushing, associated with a five-fold increase in pregnancy when performed
 preovulatory, has been proposed as a new alternative. This treatment could flush out debris
 or alter inflammatory factors preventing fertilisation and implantation. The objective of
 this study is to assess the efficacy of pre-ovulatory uterine flushing with physiological
 saline for the treatment of unexplained infertility. This study is a randomised controlled
 trial based on consecutive women aged between 18 and 37 years consulting for unexplained
 infertility for at least one year. The day of their luteinizing hormone surge, 192
 participants will be randomised in two equal groups to either receive 20 millilitres of
 physiological saline by an intra-uterine catheter or 10 millilitres of saline intravaginally.
 Investigators will assess relative risk of live birth (primary outcome), as well as pregnancy
 over one cycle of treatment. Side effects, complications, and acceptability of the
 intervention will be reported.
Inclusion Criteria:

 -  Primary or secondary infertility ≥12 months.

 -  Diagnosis of unexplained infertility ≤36 months:

 -  Anti-Mullerian hormone ≥0.4 ng/mL and/or follicle-stimulating hormone ≤13 IU/L in
 early follicular phase;

 -  regular cycle of 25-35 days,

 -  positive ovulation tests, and/or

 -  luteal phase serum progesterone ≥25mmol/L in a natural cycle;

 -  normal semen analysis;

 -  normal uterine cavity;

 -  patent tubes.

 -  Negative genitourinary test for gonorrhoea and chlamydia ≤12 months.

 Exclusion Criteria:

 -  Body mass index ≥35 kg/m2.

 -  Ongoing pregnancy.