Immunopathologic Profiles and Blood Biomarkers in Patients With IPF
Immunopathologic Profiles and Blood Biomarkers in Patients With IPF
Examination of expression of PD-L1, PD-L2, Beta- catenin, B-cell follicles and Tenascin- C in
 patients with IPF compared with other interstitial lung diseases. Examination of anti HSP 70,
 p-ANCA, c-ANCA, CD4+/CD28- and CD8+/CD28- cells in patients with IPF compared with other
 interstitial lung diseases.

 Compare the above mentioned findings with changes in pulmonary function tests, 6 minute
 walking test, exacerbation and mortality over a 2 year follow-up period.
Examination of expression of PD-L1, PD-L2, Beta- catenin, B-cell follicles and Tenascin- C in
 cryobiopsies from the lungs inpatients with IPF compared with other interstitial lung
 diseases. Examination of anti HSP 70, p-ANCA, c-ANCA, CD4+/CD28- and CD8+/CD28- cells in
 blood samples in patients with IPF compared with other interstitial lung diseases.

 Compare the above mentioned findings with changes in pulmonary function tests, 6 minute
 walking test, exacerbation and mortality over a 2 year follow-up period.
Inclusion Criteria:

 -  Patients suspected of having an ILD who are having cryobiopsies performed

 Exclusion Criteria:

 -  BMI > 35

 -  DLCO < 35%

 -  FVC < 45%

 -  Pulmonary hypertension

 -  Cardiac or other severe comorbidity that will increase the risk of complications