To Assess Efficacy of Nutritional Therapy in Secondary Prophylaxis of Hepatic Encephalopathy Versus Lactulose in Patients With Liver Cirrhosis.
To Assess Efficacy of Nutritional Therapy in Secondary Prophylaxis of Hepatic Encephalopathy Versus Lactulose in Patients With Liver Cirrhosis.
The study will be conducted on patients attending /admitted to Department of Hepatology from
 April 2017 to December 2018 at ILBS, New Delhi .

 Clinical, anthropometric and biochemical assessment will be done by candidate, co-supervisors
 and supervisor. Patients in treatment group will receive nutritional therapy in the form of
 30-kcal/kg/day and 1.5gm/kg/day protein with supplements. Other patients will continue diet
 that they were receiving before along with lactulose. Previous treatment and prophylaxis of
 variceal bleed any (endoscopic variceal ligation or beta blocker) will be continued as
 before. All subjects will be followed up every month for treatment compliance and for
 development of any complications.
Inclusion Criteria:

 1. Liver cirrhosis (Child B or Child C class)

 2. Age between 18-60 years

 3. History of recovery from episodeof overt hepatic encephalopathy (West-Haven grade 1
 and above) in last 12 months.

 Exclusion Criteria:

 1. Evidence of overt hepatic encephalopathy at the time of enrollment

 2. History of taking lactulose, rifaximin, neomycin, metronidazole, L-Ornithine
 L-Aspartate or probiotics in past 7 days

 3. Alcohol intake during past 6 weeks

 4. Receiving secondary prophylaxis for spontaneous bacterial peritonitis

 5. Previous transjugular intrahepatic portosystemic shunts or shunt surgery

 6. Significant comorbid illness such as heart, respiratory or kidney failure, and
 neurological disease such as Alzheimer's disease, Parkinson's disease and non hepatic
 metabolic encephalopathies

 7. Receiving psychoactive drugs, promotility and hypomotility drugs

 8. Hepatocellular carcinoma

 9. Electrolyte abnormality (Serum sodium <125meq/L or serum potassium <2.5meq/L)

 10. Intercurrent infection such as spontaneous bacterial peritonitis

 11. Patients of acute on chronic liver failure (ACLF).