R230C and C230C Variants of ABCA1 and Glyburide Response
R230C and C230C Variants of ABCA1 and Glyburide Response
The objective of the study is to know if the R230C and C230C variants of the ATP-binding
 cassette transporter A1 (ABCA1) gene are associated with a smaller glucose lowering effect
 compared to the wild type allele (R230R) in patients with type 2 diabetes.
Specific objectives:

 1. In patients with type 2 diabetes stratified by the existence of the risk alleles
 (R230C/C230C) or the wild variant (R230R) of ABC-A1, compare the changes resulting from
 the treatment with glibenclamide on following continuous variables:

 -  Fasting glucose

 -  Percentage reduction

 -  Hemoglobin A1c,

 -  Cholesterol, triglycerides, HDL cholesterol, LDL cholesterol

 -  Weight

 2. In patients with type 2 diabetes stratified by the existence of the risk alleles
 (R230C/C230C) or the wild variant (R230R) of ABC-A1, compare the changes resulting from
 the treatment with glibenclamide on following binomial variables:

 -  Number of cases that reach fasting plasma glucose lower than 110 mg/dl

 -  Number of cases that reach an HbA1c less than 7%
Inclusion Criteria:

 -  Adults 20 to 79 years

 -  Body mass index >18 and 39.9 ≤

 -  Men or women

 -  Mexicans mestizos.

 -  Moderate hyperglycemia (126 to 250 mg/dl and HbA1c levels between 7 and 10%) despite
 being treated with a dietary program in combination or not with metformin (2 g/d).

 Exclusion Criteria:

 -  Patients with chronic complications of diabetes: ischemic heart disease, stroke,
 proliferative retinopathy or blindness, albuminuria, chronic diarrhea, gastroparesis,
 non-traumatic amputation of lower limbs.

 -  Patients with any monogenic syndrome, obesity, diabetes or hypoalphalipoproteinemia

 -  Patients with acquired diseases that produce secondarily obesity or diabetes.

 -  Treatment with anorexigenics or accelerate weight loss at the time of the selection.

 -  Cardiovascular event in the 6 months prior to study entry.

 -  Steroids, chemotherapy, immunosuppressive or radiotherapy.

 -  Infections or concurrent acute diseases.

 -  Catabolic diseases such as cancer or AIDS

 -  Pregnancy