A Study to Assess the Safety of Single Doses of GSK189075 in Subjects With Type 1 Diabetes Mellitus
A Study to Assess the Safety of Single Doses of GSK189075 in Subjects With Type 1 Diabetes Mellitus
The purpose of this research study is to look at concentrations of GSK189075 in blood when
 single doses of the drug are taken by mouth in combination with basal insulin. The clinical
 effects of the drug in combination with insulin on the body will also be studied. The results
 will help determine doses of GSK189075 can be studied in the future in the type I diabetes
 mellitus population.
Inclusion Criteria:

 -  Adult male/female, 18 to 55 years old

 -  Diagnosis of type 1 diabetes mellitus for at least 6 months; and using a continuous
 insulin pump

 -  Willing and able to follow all study-related instructions provided by the site staff.

 -  Willing to provide signed informed consent.

 Exclusion Criteria:

 -  Pregnant or a nursing female.

 -  Have a past or current disease such as heart, liver, kidney, blood, brain, or other
 disease.

 -  Have HIV or hepatitis, or have alcohol or drugs in your system at the screening visit.

 -  Have a history of alcohol abuse or have an eating disorder

 -  Have been in another research study in the last month or have taken certain
 medications in the 1 week before study drug would be taken.