Intact Vagal Innervation for and Glucagon-like Peptide-1 (GLP-1) Effects
Intact Vagal Innervation for and Glucagon-like Peptide-1 (GLP-1) Effects
The aim of this study is to investigate the role of transmission via the vagal nerve for the
 effect of glucose and Glucagon-like peptide-1 (GLP-1) in respect to insulin secretion.

 The hypothesis is that a great deal of the effects of GLP-1 is mediated via the nervous
 system and for this reason the investigators will research individuals with and without
 intact nervous supply.
GLP-1 is a potent enterogastron and incretin hormone. It is rapidly inactivated by dipeptidyl
 peptidase IV so only 10-15% enters the systemic circulation. This has led to the hypothesis
 that GLP-1 interact locally with afferent sensory nerve fibers. We investigated the role of
 intact vagal innervations on the effect of glucose and GLP-1 on the insulin secretion
Inclusion Criteria:

 -  normal fasting plasma glucose

 -  normal hemoglobin

 -  informed consent

 Exclusion Criteria:

 -  type 1 diabetes mellitus or type 2 diabetes mellitus

 -  body mass index > 30

 -  inflammatory bowel disease

 -  intestinal surgery

 -  serum creatinine > 250 µM and/or albuminuria

 -  ALAT > 2 x normal value

 -  Severe cardiac insufficiency

 -  in treatment with medicine which cannot be paused for 12 hours