Hiperemezis and Serotonin Elevated Serum Serotonin Levels in Hyperemesis
Hiperemezis and Serotonin Elevated Serum Serotonin Levels in Hyperemesis
Serotonin excretion was investigated in the nausea and vomiting associated with hiperemezis
 gravid arum.
The occurrence of severe nausea and vomiting of early pregnancy (hiperemezis gravid arum) is
 estimated between 0.3% to 1% of all pregnancies. Although hiperemezis gravid arum has been
 recognized for a long time, its pathophysiologic mechanisms are still poorly understood. Many
 theories have been advocated, but to date none of these have been convincing.

 It has been demonstrated that the nausea and vomiting associated with increased in serotonin
 liberation. This has provided a rationale for the treatment of these symptoms with specific
 serotonin antagonists.

 The aim of this trial was to investigate the possible relationship between hiperemezis gravid
 arum and serotonin liberation.
Inclusion Criteria:

 -  6-14 week pregnant women

 -  nausea

 -  protracted vomiting

 -  inability to tolerate food intake accompanied by obvious dehydration

 -  severe enough to justify hospitalisation

 -  at least 2+ ketonuria on dipstick urinanalysis.

 Exclusion Criteria:

 -  with metabolic disorders such as diabet, thyroid