Phase 1 Trial of the TQB2928 Injection in Patients With Advanced Cancers
Phase 1 Trial of the TQB2928 Injection in Patients With Advanced Cancers
TQB2928 is a promising new molecular entity that mediates blockade of CD47 and SIRPα and
 enhances the phagocytosis of cancer cells by macrophages. In preclinical in vivo models,
 TQB2928 was active against a wide range of solid tumors and hematologic malignancies. This is
 the first-in-human phase 1 trial of TQB2928 in patients with advanced solid tumors and
 hematological malignancies.
Inclusion Criteria:

 -  1. Evidence of a personally signed and dated informed consent document indicating that
 the patient has been informed of all pertinent aspects of the study.

 2. Histologically or cytologically confirmed, locally advanced unresectable or
 metastatic solid tumors, or hematological malignancies, or lymphoma.

 3. Solid tumors or hematological malignancies that failed from standard therapy, or
 lymphoma patients who have had at least two regimens of systemic therapy failures, or
 who refused other systemic therapy.

 4. At least 1 measurable lesion according to tumor-appropriate response criteria.

 5. Must have adequate organ and bone marrow function. 6. Resolved acute effects of any
 prior therapy to baseline severity or Grade ≤1 per CTCAE v5.0 except for AEs not
 constituting a safety risk by investigator judgment.

 7. Serum pregnancy test (for females of childbearing potential) negative within 7 days
 before enrollment.

 8. Male and female patients of childbearing potential and at risk for pregnancy must
 agree to use two highly effective method(s) of contraception throughout the study and
 for at least 90 days (180 days if required by local regulation) after the last dose of
 assigned treatment.

 9. Willingness and ability to comply with the study scheduled visits, treatment plans,
 laboratory tests and other procedures.

 Exclusion Criteria:

 -  1. Patients with known symptomatic brain metastases requiring steroids. 2. Concurrent
 secondary malignancy. 3. Uncontrolled pleural effusion or pericardial effusion with
 clinical significance and requiring repeated drainage as assessed by the
 Investigators.

 4. Prior treatment with monospecific or bispecific antibodies or fusion proteins
 targeting CD47 or signal regulatory protein alpha (SIRPα).

 5. Therapeutic or experimental monoclonal antibodies within 28 days prior to
 enrollment.

 6. Immunosuppressive regimens involving systemic corticosteroids (except <10 mg daily
 prednisone equivalent) within 14 days before the first dose of study treatment.

 7. Prior allogeneic hematopoietic stem cell transplant. 8. Major surgical procedure,
 laparoscopic procedure, open biopsy or significant traumatic injury within 28 days
 prior to enrollment.

 9. RBC transfusion dependence, defined as requiring more than 2 units of RBC
 transfusions during the 4-week period prior to screening. RBC transfusions are
 permitted during screening and prior to enrollment to meet the hemoglobin inclusion
 criteria.

 10. Vaccination within 4 weeks prior to enrollment except for administration of
 inactivated vaccines (for example, inactivated influenza vaccines) 11. Active and
 clinically significant bacterial, fungal or viral infection including tuberculosis,
 hepatitis B (HBV), hepatitis C (HCV), known human immunodeficiency virus (HIV) or
 acquired immunodeficiency syndrome (AIDS)-related illness.

 12. History of hemolytic anemia or Evans syndrome within 3 months. 13. Autoimmune
 hemolytic anemia (AIHA) assessed by Positive Direct Antiglobulin Test (DAT).

 14. Autoimmune disorders (e.g., Crohn's Disease, rheumatoid arthritis, scleroderma,
 systemic lupus erythematosus) and other diseases that compromise or impair the immune
 system.

 15. Unstable or serious concurrent medical conditions in the previous 6 months. 16.
 Significant medical diseases or conditions, as assessed by the Investigators, that
 would substantially increase the risk-benefit ratio of participating in the study.

 17. Other severe acute or chronic medical or psychiatric condition, including recent
 (within the past year) or active suicidal ideation or behavior, or laboratory
 abnormality that may increase the risk associated with study participation or
 investigational product administration or may interfere with the interpretation of
 study results and, in the judgment of the investigator, would make the patient
 inappropriate for entry into this study.