Strategies to Reduce Antipsychotic-Associated Weight Gain in Youth
Strategies to Reduce Antipsychotic-Associated Weight Gain in Youth
The purpose of this pilot study is to determine whether starting metformin in conjunction
 with a second-generation antipsychotic (SGA) and providing information about healthy eating
 and activity will prevent or reduce the amount of weight gain and the metabolic changes in
 adolescent youth typically seen with second-generation antipsychotic medication.
This is a 24 week, placebo-controlled, random assignment pilot study in which participants
 will be randomized in a 1:1 ratio to receive either flexible-dose treatment with metformin
 for 6 months as well as a newly initiated second generation antipsychotic medication or to
 receive placebo and the newly initiated antipsychotic medication. All subjects will also be
 provided healthy lifestyle instruction. The study involves monthly visits for the duration of
 the study. Participants may be treated as inpatients or outpatients throughout the course of
 the study. Participants will receive a psychiatric evaluation, physical exam, lab work, ECG,
 medication treatment, and psychiatric care.

 The goal is to evaluate the safety and efficacy of means to prevent and treat weight gain and
 the associated endocrine, metabolic, and inflammatory changes caused by antipsychotic
 medications. Behavioral treatments to reduce weight gain and metabolic problems after weight
 gain has occurred have had little impact. Such interventions must be intensive and sustained
 over months, if not years to be effective. Although basic lifestyle instruction (diet and
 physical activity) should be the standard of care for all children and adolescents at risk
 for becoming overweight, pharmacologic interventions may be the best option for substantially
 augmenting behavioral approaches to weight management.
Inclusion Criteria:

 -  Subjects will be between the ages of 10 and 17, male or female, any race or ethnicity

 -  Any SPMI pediatric diagnosis that meets DSM-IV criteria and frequently is treated with
 a SGA- typically but not limited to psychotic, mood, pervasive developmental,
 oppositional defiant, and conduct disorders

 -  SGA-naïve or less than 2 weeks exposure to any SGA, except ziprasidone

 -  Legal guardian able and willing to give written informed consent

 -  If competent, subject able and willing to assent for their own participation

 Exclusion Criteria:

 -  Previous trial of metformin

 -  Recommendation for treatment with clozapine or ziprasidone

 -  Current use of insulin or any oral hypoglycemic agent

 -  Current use of a medication known to mitigate weight gain - amantidine, histamine (H2)
 antagonists (cimetidine, ranitidine, nizatidine), topiramate, orlistat, sibutramine,
 stimulants (dextroamphetamine, methylphenidate)

 -  Any current or past diagnosis of an eating disorder

 -  Diabetes mellitus

 -  Current active thyroid (TSH >18 microIU/ml; T4 total >18 mcg/dl), hepatic (2 LFTs >4x
 upper limits of normal), renal (serum Creatinine >1.4 mg/dL in females and serum
 Creatinine >1.5 mg/dL in males), cardiac, gastrointestinal, or adrenal disease

 -  Current substance abuse/dependence within past 2 weeks; a positive urine tox screen at
 baseline in the absence of meeting criteria for abuse/dependence will not preclude
 enrollment.

 -  Pregnancy or breast feeding