Effect of Genes on Rosuvastatin Therapy for Hyperlipidemia
Effect of Genes on Rosuvastatin Therapy for Hyperlipidemia
Previous studies indicate that the variant status of detoxification proteins is different
 among Taiwanese and other ethnic groups. For example, in Taiwanese, the major SNPs of CYP2C9
 are CYP2C9*2 (430C>T) and CYP2C9*3 (1075A>C) and their frequencies are different from that in
 Caucasians [11]. The second example is that the frequency of the A(TA)7TAA allele in the
 promoter area of the UGT1A1 gene is substantially lower, while for the rate of variation
 within the coding region is much higher in Taiwanese than that in Caucasians (14.3% vs. 35.7-
 41.5% and 29.3% vs. 0.1%, respectively) [12]. The third example is that the frequency of
 388A>G of the OATP2 gene in Taiwanese (0.68) [13] is in between that in European Americans
 (0.30) and African Americans (0.74) [14]. Therefore, the investigators hypothesize that, in
 Taiwanese the SNPs of detoxification proteins modulate the lipid-lowing effects of RVA and
 fenofibrate may be different from those for Caucasians.
Since April 2008, we have started to run a multicenter, prospective, randomized, open-label,
 blinded end-point classification trial to test the hypothesis in Taiwan that the addition of
 fibrate on statin would provide a further reduction in the major coronary events in the
 patients with diabetes or atherosclerotic vascular diseases with metabolic syndrome. With the
 advantage of this large-scaled prospective trial, it is also a good opportunity to identify
 simultaneously the genetic determinants of wide range of interindividual variability in
 phenotypic and clinical response to two major lipid-lowering drug classes, rosuvastatin and
 fenofibrate. The aim of this proposal is to find which SNPs influence the therapeutic
 effectiveness of lipid lowering therapy in Taiwanese hyperlipidemic patients. A key feature
 is the use of multiple drug-treated population samples to get the findings derived from both
 candidate gene and genome-wide searches for SNP associations with markers of drug efficacy as
 well as side effects. Thus the promise of pharmacogenomics and metabolomics-- "individualized
 medicine" will come true in treating hyperlipidemia in Taiwanese.
Inclusion Criteria:

 -  Men or women aged 20-79 years with definite DM or atherosclerotic vascular diseases
 with metabolic syndrome, defined as the presence of three or more of the following
 risk factors:

 -  abdominal obesity (waist circumference > 90 cm in men or > 80 cm in women),

 -  triglycerides > 150 mg/dL, HDL-cholesterol < 40 mg/dL in men or < 50 mg/dL in
 women,

 -  blood pressure > 130/85 mm Hg, or

 -  fasting glucose > 100 mg/dL).

 -  Those who are qualified for lipid lowering therapy according to the Taiwanese national
 guidelines (LDL-C 130-190 mg/dL or TG 200-500 mg/dL with HDL-C < 40 mg/dL or TC/HDL-C
 > 5).

 Exclusion Criteria:

 -  Any known contraindications to statin or fibrate therapy,

 -  Previous intolerance to statin or fibrate in low or high doses,

 -  Liver enzyme levels more than 3 times the upper limit of normal,

 -  Pregnancy or breastfeeding,

 -  Nephrotic syndrome,

 -  Uncontrolled diabetes mellitus (HbA1c > 9),

 -  Uncontrolled hypothyroidism,

 -  Plasma LDL-C level higher than 190 mg/dL or triglyceride level higher than 500 mg/dL,

 -  Coronary heart disease event or revascularisation within a month,

 -  Congestive heart failure (New York Heart Association classification IIIb or IV),

 -  Hemodynamically important valvular heart disease,

 -  Gastrointestinal conditions affecting absorption of drugs,

 -  Treatment with other drugs that seriously affect the pharmacokinetics of statins or
 fibrate,

 -  Unexplained creatine phosphokinase concentrations six or more times the upper limit of
 normal,

 -  Life-threatening malignancy,

 -  Treatment with immuno suppressive or other lipid lowering drugs.

 -  Patients previously treated with monotherapy with statins or fibrates will be
 qualified if they have not already had titration to a dose higher than the equivalent
 of 5 mg/d of rosuvastatin or 160 mg/d of SFC fenofibrate.