Molecular Genetic Screening and Identification of Congenital Arrhythmogenic Diseases
Molecular Genetic Screening and Identification of Congenital Arrhythmogenic Diseases
The aim of this study is the identification of familial congenital arrhythmogenic disorders
 and their clinical follow-up.
Molecular genetic screening in patients with:

 -  supraventricular

 -  ventricular arrhythmia

 -  syncopes of unknown origin and/or suspicion of an arrhythmogenic origin

 -  family members of patients with sudden cardiac death and aborted sudden cardiac death

 Examination of patients includes routine testing like electrocardiogram (ECG), sequential
 ECGs, exercise testing, invasive electrophysiological stimulation, cardiac magnetic resonance
 imaging, intravenous drug challenge for identification/exclusion of eg Brugada syndrome.
 Examples are patients with Long QT Syndrome, Short QT Syndrome, Brugada Syndrome, familial
 atrial fibrillation, WPW-syndrome, arrhythmias due to familial hypertrophic cardiomyopathy or
 arrhythmogenic right ventricular dysplasia. Blood samples are taken for further molecular
 genetic screening.
Inclusion Criteria:

 -  Patients with a history of syncope, abnormal ECG and suspicion of an arrhythmogenic
 disease

 -  Patients with long QT syndrome

 -  Patients with short QT syndrome, shortened QT intervals, borderline shortened QT
 intervals

 -  Patients with Brugada syndrome

 -  Patients with hypertrophic cardiomyopathy

 -  Patients with arrhythmogenic right ventricular dysplasia

 Exclusion Criteria:

 -  Inability to understand study protocol