The Effects of Vitamin D on Glycemic Control and Proinflammatory Markers in Adolescents With T1DM
The Effects of Vitamin D on Glycemic Control and Proinflammatory Markers in Adolescents With T1DM
The investigators are conducting a prospective cross-over study to evaluate the effects of
 vitamin D supplementation on diabetes control and the pro-inflammatory markers involved in
 microvascular complications in adolescents with Type 1 Diabetes. The investigators expect to
 see a significant improvement in glycemic control and a reduction of serum pro-inflammatory
 markers in adolescents with Type 1 Diabetes and vitamin D deficiency or insufficiency, who
 are treated with vitamin D.
Inclusion Criteria:

 1. Between 13 to 21 years of age, with at least Tanner stage 4 sexual maturity for males
 or post-menarchal females, and T1DM for at least 1 year. To ensure that inclusion
 criteria for sexual maturity are met, a physical exam for research purposes will be
 performed.

 2. HbA1c between 7 to 9%

 3. Adequate renal function (serum creatinine < 1.5 mg/dL in males and < 1.2 mg/dL in
 females) and adequate liver function (AST and ALT < 2.5 times the upper limit of
 normal)

 4. Vitamin D insufficiency or deficiency (25-OH vit D level < 30ng/mL) which will be
 determined on initial screening labs after consenting subjects.

 Exclusion Criteria:

 1. Less than 13 or greater than 21 years of age

 2. Less than Tanner stage 4 sexual maturity for males or pre-menarche

 3. HbA1c less than 7% or greater than 9%

 4. T1DM for less than 1 year

 5. Vitamin D sufficient (25-OH vit D level > 30 ng/mL)

 6. Currently taking any medication that can interfere with vitamin D synthesis or
 metabolism, including but not limited to Orlistat, Phenobarbital, Dilantin,
 Anti-tuberculosis drugs

 7. Currently taking any medication other than insulin that alters blood glucose levels,
 including but not limited to systemic glucocorticoids

 8. Inadequate renal function (serum creatinine > 1.5mg/dL in males and > 1.2mg/dL in
 females) or inadequate liver function (AST and ALT > 2.5 times the upper limit of
 normal)

 9. Evidence of malabsorption or short gut.