Diastolic RV EvAluation With Millar Catheter to Investigate the Effect of Glucagon-Like Peptide-1 (GLP-1) on Right Ventricular Function During Elective Coronary Angioplasty and Stenting
Diastolic RV EvAluation With Millar Catheter to Investigate the Effect of Glucagon-Like Peptide-1 (GLP-1) on Right Ventricular Function During Elective Coronary Angioplasty and Stenting
The heart requires nutrients and oxygen carried in the blood to generate energy for healthy
 pump function. Blood is supplied via heart vessels called coronary arteries. When the
 arteries narrow the investigators call this coronary artery disease. Narrowing and blockage
 of the coronary arteries can cause chest pain (angina), breathlessness (due to a reduction in
 pump function) and if prolonged even irreversible muscle damage known as a heart attack. The
 investigators can treat patients with coronary artery disease with drugs that reduce the
 workload on the heart or with balloons and hollow metal tubes (stents) to open the narrowed
 coronary arteries and improve the blood supply. These treatments can relieve angina, improve
 breathlessness and avert heart muscle damage during a heart attack. A potential new
 mechanistic effect is emerging by modulating the type of fuel used by the heart to generate
 energy more efficiently has been tested in the left ventricle. This study is designed to see
 if mechanistic effect provides the same protection in the right ventricle. It is hoped that
 this may further improve heart pump function and reduce the size of a heart attack in
 patients with coronary artery disease.
Inclusion Criteria:

 -  Age over 18

 -  Able to give informed consent

 -  Elective percutaneous intervention for a single vessel right coronary artery stenosis
 >75%

 -  Normal right ventricular function

 Exclusion Criteria:

 -  Severe co-morbidity expected life (<6months)

 -  Nicorandil or a GLP-1 receptor agonist or DPP-4 inhibitor use

 -  Women of child bearing age

 -  Myocardial infarction within the previous 3 months

 -  Previous coronary artery bypass graft to the RCA

 -  Significant known left to right shunt

 -  Permanent pacemaker

 -  Atrial fibrillation