Effect of Dexmedetomidine Combined With Sufentanil for Postoperative Intravenous Analgesia in Neurosurgery
Effect of Dexmedetomidine Combined With Sufentanil for Postoperative Intravenous Analgesia in Neurosurgery
The purpose of this study is to determine effect of combined medication of sufentanil and
 dexmedetomidine in patient controlled analgesia after neurosurgery.
Sufentanil is a classical drug for postoperative analgesia. Dexmedetomidine is a commonly
 used α2-adrenergic receptor, and it helps provide sedation, analgesia and inhibition of
 sympathetic activation. The investigators propose to recruit 120 patients who is undergoing
 the arteriovenous malformation embolism operation in department of Neurosurgery. Patients
 will be randomly divided into 4 groups(control group, sufentanil and low dexmedetomidine dose
 group, sufentanil and middle dexmedetomidine dose group, sufentanil and high dexmedetomidine
 dose group), then the investigators select post-operative records to determine whether
 dexmedetomidine can take a positive role in neurosurgical analgesia.
Inclusion Criteria:

 1. patients undergoing venous malformation embolization operation through general
 anesthesia.

 2. aged 18-65 years old.

 3. operating time varies 1-4h,and extubation after the operation.

 Exclusion Criteria:

 1. long-term use of analgesics,sedatives or non steroidal anti-inflammatory drugs
 history.

 2. known for dexmedetomidine or other drugs allergy in this study.

 3. cannot communicate.

 4. preoperative systolic blood pressure <90 mmHg, or the heart rate <50/min.