Modified Adaptive Servoventilation (ASV) Compared to Conventional ASV
Modified Adaptive Servoventilation (ASV) Compared to Conventional ASV
This study will determine if modified adaptive servoventilation (ASV) is as effective as the
 conventional ASV in treating periodic breathing. The study will determine if the modified ASV
 reacts appropriately to reduce apneas and hypopneas and provides suitable levels of positive
 airway pressure compared to conventional ASV.
Adaptive servoventilation (ASV) is a type of non-invasive ventilation which ameliorates
 central sleep and/or mixed apnea and periodic breathing. Previous studies in the field have
 shown that treatment of periodic breathing with ASV improves sleep quality and quality of
 life. In reducing central apneas, ASV reduces overall arousal index, and increases overall
 slow wave sleep and rapid eye movement (REM) sleep more than oxygen, continuous positive
 airway pressure or bi-level treatments. ASV can also more effectively reduce central apnea
 and overall apnea/hypopnea index (AHI) in patients on long-term opiates, and appears to
 effectively treat Complex Sleep Apnea Syndrome. It is more effective than other forms of
 non-invasive ventilation for patients with central and/or mixed apnea or periodic breathing,
 and is better tolerated.

 This is a prospective, randomised, crossover, observational study. Subjects will spend one
 night on conventional ASV and one night on modified ASV with full in-lab polysomnography
 (PSG) during therapy on both nights.

 Objective and subjective parameters will be recorded and analysed.
Inclusion Criteria:

 -  21+ years old

 -  Chronic ResMed ASV therapy patient

 -  Current ASV therapy for at least 4 weeks

 -  Able to understand fully the study information and participation requirements

 -  Provide signed informed consent

 Exclusion Criteria:

 -  Acute cardiac decompensation

 -  Acute myocardial infarction within last 3 months

 -  Resuscitation within last 3 months

 -  Stroke with swallowing disorders or persistent hemiparesis

 -  Blood pressure test at end expiratory pressure (EEP) 10cmH2O not passed

 -  Untreated restless legs syndrome

 -  Alcohol or drug abuse

 -  Known cancer

 -  Pregnancy

 -  Conditions that could interfere with patients participating in and completing the
 protocol and/or the investigator deems their enrolment unsuitable