Effect of Evidence-based Reminders on Use of Antibiotics
Effect of Evidence-based Reminders on Use of Antibiotics
Inappropriate use of antibiotics in primary care is associated with Development of antibiotic
 resistant strains. As part of a quality improvement program carried out in primary care in
 Uruguay, Argentina, Paraguay and Bolivia, a cluster randomized control trial was performed.
 The aim of the study was to assess whether the use of continuous evidence-based feedback
 about management of respiratory tract infections could decrease use of antibiotics in Acute
 bronchitis, common cold and acute otitis media.
Excessive and inappropriate use of antibiotics is one of the most important reasons for
 development of resistant bacteria.

 One of the key strategies to curb the development of antibiotic resistance is to promote
 intervention at primary care level as more than 90% of antibiotics are prescribed by general
 practitioners - especially in patients suffering from respiratory tract infections.

 The main bacteria causing respiratory tract infections are S. pneumoniae y Haemophilus
 influenzae. The first one is associated with a significant increase in morbidity and
 mortality in Latin America.

 Approximately 80% of respiratory tract infections have a viral cause, are harmless and
 self-limiting and in most cases patients recover without specific treatment. Antibiotic
 treatment is superfluous and in some cases even harmful because of side effects.

 Infections caused by resistant bacteria leads to increased mortality, prolonged hospital stay
 and social collateral damage. Therefore, in 2013 the World Economic Forum pointed out
 antibiotic resistance as one of the three most important threats to economic and social
 development.

 The World Health Organisation (WHO) launched in 20121 a global strategy to hold back
 antimicrobial resistance. According to this strategy "the battle against infectious diseases
 is far from being over. Not only do they continue to cause a large number of infections and
 deaths, particularly in developing countries, but the emergence and spread of antimicrobial
 resistance is now also threatening to undermine our ability to treat infections and save
 lives". The WHO has proposed a number of initiatives against the emergence of resistant
 bacteria, including interventions to promote proper use of antibiotics.

 HAPPY AUDIT II (HA-II) - PART OF THE SOLUTION

 HAPPY AUDIT - II is the second phase of HAPPY AUDIT - I, which was a project funded by the
 European Union to promote appropriate use of antibiotics in 6 countries with a very
 heterogeneous pattern of consumption of antibiotics and prevalence of resistant strains.

 440 general practitioners registered data in winter 2008 and 2009. Inappropriate antibiotic
 use was reduced by 10% and in pathologies such as acute bronchitis, there was a 50% reduction
 in use of antibiotics.

 In Argentina, 48 general practitioners participated in the whole process and reached a 30%
 reduction of unnecessary prescriptions of antibiotics in patients with acute bronchitis,
 sinusitis and pharyngitis.

 The positive experience of the first phase has shown the importance and the potential to
 spread the project to other provinces of Argentina and other South American countries. Our
 prior knowledge will be used in the HAPPY AUDIT II SOUTH AMERICA to plan interventions for
 patients and GPs through the methodology APO (Audit Project Odense) which is based on:

 1. self-reflection of physicians and group discussion on their prescription patterns,

 2. patient education,

 3. Development of a multi-faceted intervention.

 The overall purpose of the project is to promote the rational use of antibiotics. This will
 be achieved through the following specific objectives:

 1. Preparation of intervention materials for patients and professionals.

 2. Implementation of APO cycles in 4 countries.

 3. Initial registration of GPs and use of antibiotics for their RTI patients.

 4. Analysis of the results of the first registration to identify quality problems in
 prescription.

 5. Development of a multifaceted intervention.

 6. Implementation of a cluster randomized control trial to assess the effect of the
 intervention.

 7. Final registration to evaluate the effect of the intervention.

 PROJECT ORGANIZATION

 180 GPs will participate: Argentina 80 physicians, Bolivia 30 physicians, Paraguay 40
 physicians and Uruguay 30 physicians.

 The investigators will use the APO methodology, which based on a "bottom-up" approach seeks
 to change practice behaviour among GPs. The GPs voluntarily participate and set their own
 quality criteria in order to improve the quality of their own service.

 The APO method includes:

 -  Initial registration of GPs own activities (3 weeks)

 -  Intervention (online evidence-based reminders during final registration)

 -  Final registration and evaluation (3 weeks)

 Schedule 2014

 February - May 2014 - coordinators and researchers first meeting

 June - August 2014 - First audit registration during 15 days.

 October 2014 - Coordinators and researchers second meeting

 March 2015 - Meeting with General Practitioners from all provinces and/ or countries. This
 meeting will be divided into two parts:

 1. Discussion of the results from the first registration;

 2. Discussion about the use of quality indicators to decrease inappropriate use of
 antibiotics.

 June - August 2015 - Second registration, intervention (online weekly feedback on
 evidence-based management of respiratory tract infections)

 November 2016 - Assessment of the intervention.

 April 2017 - Publication of results
Inclusion Criteria:

 -  General practitioners working in primary care

 -  Patients with suspected respiratory tract infection

 Exclusion Criteria:

 -  Patients that have already started an antibiotic