Multimodal Spectroscopy to Detect Urothelial Cancer in Urine
Multimodal Spectroscopy to Detect Urothelial Cancer in Urine
To facilitate the follow-up of urothelial tumors and also make them more tolerable and less
 invasive for patients, there is a minimally invasive and easy to perform examination which is
 urinary cytology on 3 samples. This test is extremely specific, over 90% chance of cancer if
 it is positive and is performed by expert cytopathologists, but it is burdened by a very low
 sensitivity, which is especially acute in the case of low grade tumors. This makes it an
 extremely useful test in case of positivity, but of little use if negative or doubtful, not
 being able to consider it reliable.

 To overcome this problem, our study aims to bring an approach based on a physical principle,
 that is spectroscopy, which is fast non-invasive and does not require the use of additional
 substances or contrast media in the diagnosis of urothelial neoplasms in samples of urine.

 In our experience, multimodal optical fiber spectroscopy has proved extremely valid in
 discriminating healthy urothelial tissue from tumor ex vivo, as well as providing important
 information on the degree of urothelial neoplasia, with accuracy rates higher than 80%, for
 which developed the idea of a technique based on multimodal spectroscopy.

 If our method proves valid, it could improve the follow up and management of patients with
 urothelial cancer, being able to support normal cytology and provide further support to the
 cytopathologist, as well as simplify the diagnosis.
CASES Inclusion criteria

 Patients over the age of 18 who are known for urological interventions for the following
 pathologies will be considered for enrollment in the group of cases:

 -  Bladder cancer

 -  Urethral tumor

 -  Renal Pelvis Tumor

 -  Ureteral tumor

 The exclusion criteria will be:

 -  Age under 18

 -  Pregnancy

 -  Lack of informed consent

 -  Persons with indwelling catheter

 -  Presence of prostate cancer

 -  Presence and / or history of renal cancer, except tumors of the renal pelvis

 CHECKS Inclusion criteria

 Patients over the age of 18 who are known for urological interventions for the following
 pathologies will be considered for enrollment in the control group:

 -  Kidney, ureteral or bladder stones

 -  BPH

 The exclusion criteria will be:

 -  Age under 18

 -  Pregnancy

 -  Lack of informed consent

 -  Indwelling Catheter wearers

 -  Presence of prostate cancer

 -  Presence of kidney cancer, including kidney pelvic tumors

 -  Presence and / or history of ureteral cancer

 -  Presence and / or history of bladder cancer

 -  Presence and / or history of urethral cancer