Value of Ondansetron Medication vs Inhaled Isopropyl Therapy in the Emergency Department (VOMIITED)
Value of Ondansetron Medication vs Inhaled Isopropyl Therapy in the Emergency Department (VOMIITED)
This study will compare two different ways to relieve nausea and vomiting in the Emergency
 Department. The usual treatment for nausea/vomiting is a drug called Zofran, but new studies
 have suggested that smelling alcohol pads can also help to relieve nausea and vomiting.
Emergency physicians commonly use medications to alleviate nausea and vomiting. The
 medication Ondansetron is used in the emergency department and after surgery for this
 purpose. Inhaled isopropyl alcohol has been successfully used to decrease nausea and vomiting
 after surgery. No trial has compared inhaled isopropyl alcohol to Ondansetron in a clinical
 trial.

 The author proposes to prospectively investigate extension of the established antiemetic
 efficacy of inhaled isopropyl alcohol for undifferentiated nausea in Emergency Department
 patients to the 30-minute post-intervention point that has been reported to be the frequent
 juncture of symptom relief. By introducing prolonged intervention, and re-dosing of
 established benefit, into this research, the author aims to reproduce the sustained
 antiemetic efficacy of inhaled isopropyl alcohol for undifferentiated nausea as demonstrated
 for post-operative nausea and vomiting.
Inclusion Criteria:

 -  Patients aged 18-65 years presenting to the emergency department complaining of
 current nausea with or without episodes of emesis beginning within the previous 24hrs

 Exclusion Criteria:

 -  Patients with known allergy to isopropyl alcohol

 -  Patients outside of the defined age range

 -  Patients with an inability to inhale through the nares (including recent upper
 respiratory infection)

 -  Patients greater than 20 weeks estimated gestation

 -  Patients with past medical history of gastroparesis, or hemoptysis

 -  Patients who have taken an antiemetic medication in the past 48 hours

 -  Patients demonstrating hemodynamic instability with systolic blood pressure <90 or
 tachycardia >120 bpm