Curcumin for Type 2 Diabetic Patients
Curcumin for Type 2 Diabetic Patients
There are evidence that there is an association between insulin resistance and prolonged
 hyperinsulinemia or hyperglycemia in Type 2 diabetic patients. This will trigger oxidative
 stress system via reactive oxygen species (ROS) and lead to a high level of Nitric oxide.
 This can contribute to a significant change in blood vessel and could end up with the
 complications from cardiovascular disease and increased mortality rate of type 2 diabetic
 patients. The purpose of the present study was to examine the effectiveness of the curcumin
 in type 2 diabetic patients on the reduction of atherosclerosis events by examining
 pulse-wave velocity (PWV) and plasma high-sensitivity C-reactive protein (CRP) test and on
 blood sugar lowering, glycosylated hemoglobin (HBA1c), lipid profile, and insulin resistance.
Inclusion Criteria:

 -  Diabetic patients aged 35 years or older and did not use insulin during the first 5
 years of treatment after being diagnosed (with or without symptoms listed in the
 following inclusion criteria)

 -  Patient with hyperlipidemia (Cholesterol ≥ 200 mg/dl, TG ≥ 150 mg/dl, LDL ≥ 100 mg/dl
 and HDL ≥ 35 mg/dl)

 -  Patient with hypertension (Blood pressure ≥ 130/85 mmHg or take hypertensive drugs)

 -  Obesity (BMI ≥ 25)

 Exclusion Criteria:

 -  Current diagnosis of secondary peripheral arterial disease (PAD) (except listed in the
 inclusion criteria item 1-4)

 -  Current diagnosis of cardiovascular disease, i.e., coronary arterial disease and
 cerebrovascular disease

 -  Current diagnosis of end stage renal function with serum creatinine > 2.0 mg/dl or on
 renal dialysis

 -  Current diagnosis of cirrhosis with ALT ≥ 3 times of normal range