Vaginal Microbiota, and STI/HIV Risk Among Adolescent Girls and Young Women
Vaginal Microbiota, and STI/HIV Risk Among Adolescent Girls and Young Women
The investigators are doing a study on the bacteria that normally live in the vagina and what
 effect, if any, Depo-Provera has on the bacteria.

 Women 13-24 years of age, who are HIV negative, being seen in a clinic for birth control or
 sexually transmitted disease (STD) check-up, or have a child and are planning to receive a
 Depo-Provera shot for contraception or have declined the use of hormonal contraception may
 join.
The investigators are doing a study on the bacteria that normally live in the vagina and what
 effect, if any, Depo-Provera has on the bacteria.

 Women 13-24 years of age, who are HIV negative, being seen in a clinic for birth control or
 STD check-up, or have a child and are planning to receive a Depo-Provera shot for
 contraception or have declined the use of hormonal contraception may join.
Inclusion Criteria:

 -  Age 13-24

 -  Female sex

 -  Seeking contraceptive/ STI services OR has had a child OR is legally married

 -  Has had consensual vaginal sex

 -  Two years have passed since menses started

 -  HIV negative by self-report

 -  Willing to refrain from using douches, washes, or other similar feminine hygiene
 products. (Tampons are allowed)

 -  Planning to receive the Depo-Provera shot, -OR- Have regular menstrual cycles with at
 least 21 - 45 days between menses and plans to use no hormonal birth control.

 Exclusion Criteria:

 -  Any other immunodeficiency (e.g. organ transplant recipient)

 -  Recently pregnant (within 4 weeks), currently pregnant, or planning to become pregnant
 within the next 12 months

 -  Currently breastfeeding

 -  Hysterectomy or a known genital tract anomaly

 -  Amenorrhea (except if caused by contraceptive method like the implant)

 -  Antibiotic or antifungal use within past 30 days