Anterior Bridging Cage With Bone Substitute Versus Localized Autobone in Transforaminal Lumbar Interbody Arthrodesis
Anterior Bridging Cage With Bone Substitute Versus Localized Autobone in Transforaminal Lumbar Interbody Arthrodesis
The purpose of this study is to evaluation for the pattern of bone bridging of patients who
 undergo transforaminal lumbar interbody arthrodesis, the investigators hypothesize that auto
 local bone mixed with β-calcium phosphate + hydroxyapatite (OSTEON 2, Genoss) is not inferior
 to auto local bone only. In addition, the investigators will analyze anterior new bone
 bridging pattern between anterior bridging cage newly developed and grafted bone in anterior
 disc space.
A single center, matched pairs, case controlled, single arm study to evaluate the efficacy of
 auto local bone mixed with β-calcium phosphate + hydroxyapatite using interbody fusion
 assessment on multi-axial CT scan. Its active comparator is auto local bone.

 Anterior bridging bone between anterior grafted bone and inserted cage will be assessed by
 using newly developed anterior bridging cage as well as interbody bone bridging between two
 vertebral bodies on multi-axial reconstructed CT scan.

 The patients undergoes arthrodesis surgery will have two cages, one augmented with auto local
 bone will be located at left side of disc space and the other cage augmented with auto local
 bone mixed with β-calcium phosphate + hydroxyapatite at right side of disc space.
Inclusion Criteria:

 -  Patients who need lumbar interbody fusion in Degenerative spine disease on
 L1-S1(Spinal stenosis, HIVD and internal derangement of disk, spine instability)

 -  Patients who have no communication problems

 -  Patients who are willing to visit the hospital for any follow-up assessment

 -  Patients who voluntarily sign on a written consent

 Exclusion Criteria:

 -  Patients who have infection

 -  Patients who have bleeding disorders

 -  Patients who have immunosuppressed disease

 -  Patients who can't sign on consent form

 -  Patients who are in pregnancy or breast feeding

 -  Patients who have severe osteoporosis

 -  Patients who can't take general surgery because of severe liver disease or decreased
 renal function

 -  Patients who have acute spinal injury, spinal tumor or inflammatory spinal disease