The Effect of Melatonin on Nocturnal Enuresis
The Effect of Melatonin on Nocturnal Enuresis
Aim: To investigate the effect of melatonin in bedwetting.
Design: Double blind randomized placebocontrolled trial using crossover.
Inclusion Criteria:

 -  Monosymptomatic nocturnal enuresis

 -  Age 6-14 years

 -  Clinical examination normal

 -  ≥ 3 wet nights / week due to either nocturnal polyuria with normal bladder size or
 reduced functional bladder capacity with normal urine output

 Exclusion Criteria:

 -  Constipation (by ROME III criteria)

 -  Day incontinence

 -  Overactive bladder (ICCS 2008 classification of symptoms)

 -  Current or past history of clinical or laboratory findings that can be related to
 diseases or - conditions (eg pregnancy) likely to change the parameters examined,
 especially diseases of the kidney and urinary tract, liver or endocrine disorder.

 -  Clinical signs of urinary tract infection

 -  Hypertension, blood pressure assessed by ambulatory measurement with blood pressure
 cuff

 -  Set treatment with one or more drugs