Helium-Hyperoxia and 6MWT Distance in COPD
Helium-Hyperoxia and 6MWT Distance in COPD
We assessed the effect of altering inspired gas on the 6MWT distance in COPD. We hypothesized
 that HeO2 would improve walking distance and reduce shortness of breath compared to both RA
 and O2, and potentially improve quality of life for COPD patients.
We hypothesized that inspiring helium-hyperoxia (HeO2) would significantly improve 6-minute
 walking test (6MWT) distance in Chronic Obstructive Pulmonary Disease (COPD) subjects.

 This was a blinded, randomized crossover study. At Visit 1 we assessed pulmonary function,
 exercise capacity and 6MWT distance. Visits 2 and 3 consisted of four 6MWT with different
 inspired gases: room air by mask (RA), 100% O2 by mask (Mask O2), 100% O2 by nasal prongs
 (Nasal O2), and 70% He/30% O2 by mask (HeO2). Walking distance, shortness of breath, leg
 fatigue, O2 saturation and heart rate (HR) were assessed
Inclusion Criteria:

 -  Exertional dyspnea

 -  Activity limitation

 -  COPD

 Exclusion Criteria:

 -  Recent exacerbation (< 4 wks)

 -  Supplemental O2

 -  Significant cardiovascular/musculoskeletal abnormalities