Study of the Anti-angiogenesis Agent AG-013736 in Patients With Metastatic Thyroid Cancer
Study of the Anti-angiogenesis Agent AG-013736 in Patients With Metastatic Thyroid Cancer
This is a Phase 2 study being conducted at multiple centers in the United States. Patients
 having thyroid cancer that has spread to other parts of the body (i.e., metastatic) are
 eligible to participate. Patients must have disease that was not controlled by previous
 treatment with radioactive iodine (131I) or not be good candidates for such treatment. The
 purpose of the study is to test whether the angiogenesis inhibitor AG-013736 is an effective
 treatment for metastatic thyroid cancer as shown by the number of patients in the study who
 experience significant and durable tumor shrinkage.
Inclusion Criteria:

 -  Histologically documented thyroid cancer with metastases.

 -  Failure of radioactive iodine (131I) to control the disease or radioactive iodine
 (131I) is not an appropriate therapy (e.g. due to lack of iodine uptake by the tumor)

 Exclusion Criteria:

 -  Central lung lesions involving major blood vessels (arteries or veins).(Central
 lesions that maintain the structural integrity of vessels have the potential to bleed
 if the tumor lesion undergoes necrosis. MRI or CT angiography should be used in any
 case where there is any question as to whether blood vessels are involved.)

 -  Patients with a history of hemoptysis