Risk Factors of Hypertensive Urgencies
Risk Factors of Hypertensive Urgencies
The purpose of this study is to determine whether frequent hypertensive urgencies increase
 the risk of cardiovascular events in patients with arterial hypertension.
The spectrum of disorders associated with arterial hypertension (AH) encompasses chronic
 uncomplicated hypertension and the hypertensive crises, including hypertensive urgences and
 emergencies. Hypertensive crises accounted for more than 25% of all patient visits to a
 medical section of an emergency department, with hypertensive urgences (HU) accounting for
 two-third of these cases. Hypertensive crises, without prompt treatment, are often associated
 with morbidity and mortality. We propose to conduct a population-based case-control study of
 HU in areas of the Russian Federation. We will include about thirty study centers and one
 data coordinating center and will recruit study participants over a period of one years. We
 plan to conduct in-person interviews with 1,500 cases and 1,500 controls to elicit
 information on demographic background and history of exposures. We intend to test about 20-25
 risk factors of HU thus calculated target number of subject is 3000 pts. We're going to get
 access to hospital lists in each study center. From the database we'll select patients with
 AH and recruit every third participant who came to hospital or/and policlinic. Every selected
 participant will be asked to respond to some questions by phone and be divided into two
 groups. Participants who have HU two weeks before the call will be questioned about level of
 arterial pressure and treatment during HU. Participants with often HU (every week or more)
 will be included into first group (prevalent cases, group A). Participants with seldom HU
 (every month or less) will be included into second group (controls, group B). Cases and
 controls will be selected from the same population of AH patients. Questionnaire contains
 information about age, gender, tobacco use, data about HU (frequency, treatment and its
 complications), antihypertensive and concomitant treatment, level of blood pressure,
 regularity of taking antihypertensive drugs, associated clinical conditions (cerebrovascular
 disease, heart disease, renal disease, peripheral vascular disease), PCI, CABG, if it be
 possible we intend to collect information of factors influencing prognosis (fasting plasma
 glucose, dyslipidaemia, serum creatinine, serum uric acid, left ventricular hypertrophy).
Inclusion Criteria:

 -  Cases: every third patient from hospital/policlinic database who are diagnosed with
 arterial hypertension (SBP/DBP>140/90 Hg or taking anti hypertensive drugs) and with
 frequent (weekly or daily) hypertensive urgencies (SBP/DBP≥180/110 Hg) will be
 potentially eligible for the study.

 -  Controls will be selected from the same population of participants by random telephone
 dialing to every third patient with arterial hypertension (SBP/DBP>140/90 Hg or taking
 anti hypertensive drugs) and with seldom (monthly, several times in the year or never)
 hypertensive urgencies.

 Exclusion Criteria:

 -  Hypertensive emergency