Long-Term Growth and Skeletal Effects of Early Growth Hormone Treatment in Turner Syndrome
Long-Term Growth and Skeletal Effects of Early Growth Hormone Treatment in Turner Syndrome
This is an extension study that will gather long-term data on the effect of early growth
 hormone (GH) treatment on adult height and other aspects of health and development in girls
 with Turner syndrome. The main purpose is to determine whether girls who received 2 years of
 GH treatment before 6 years of age achieve taller adult height than girls who were untreated
 during this time. The study will also look at middle ear and hearing function, and cognitive
 and behavioral development. Protocol completion is defined as attainment of height velocity
 less than or equal to 1.0 cm/year, or bone age greater than or equal to 15 years.
Inclusion Criteria:

 -  Previously randomized in study B9R-US-GDFG (NCT00406926)

 -  Karyotype-proven Turner syndrome

 Exclusion Criteria:

 -  Immediate family members of study site personnel directly affiliated with the study