NET-PD LS-1 Creatine in Parkinson's Disease
NET-PD LS-1 Creatine in Parkinson's Disease
The purpose of this trial is to determine if the nutritional supplement creatine slows the
 progression of Parkinson's disease over time.
Parkinson's disease (PD) affects nearly a million Americans, a number that will increase over
 the coming decades as the population ages. Symptoms of PD may include tremor, rigidity or
 stiffness of the limbs and trunk, slowness of movement, and impaired balance and
 coordination. These problems occur because as PD worsens, some of the brain cells that
 control body movement die.

 This study will determine if creatine--an investigational compound--is able to slow the
 progression of PD. Creatine, a widely used dietary supplement is thought to improve exercise
 performance. In animal models and human studies, creatine has been shown to be well tolerated
 and may have some ability to protect brain cells.

 In the NET-PD LS-1 study, 1,720 participants will be randomly assigned to receive either
 creatine or a placebo (inactive substance). Participation in this study lasts a minimum of 5
 years and includes at least 9 follow-up clinic visits and at least 3 telephone calls.
Inclusion Criteria:

 -  Willing and able to give informed consent and willing to commit to long-term follow-up

 -  PD (asymmetric features including slowness (bradykinesia) plus resting tremor and/or
 rigidity) within 5 years of diagnosis

 -  Treated/responsive to dopaminergic therapy (dopamine agonists or levodopa) for at
 least 90 days, but not more than 2 years.

 Exclusion Criteria:

 -  Use of creatine 14 days prior to baseline or during the study

 -  History of known hypersensitivity or intolerability to creatine

 -  Any unstable or clinically significant condition that would impair the subject's
 ability to comply with long term study follow-up

 -  Other know or suspected causes of parkinsonism (e.g. metabolic, drug induced, etc.),
 or any significant features suggestive of a diagnosis of atypical parkinsonism.