The Neuromarker S-100B in Patients With Different Types of Intracranial Injury
The Neuromarker S-100B in Patients With Different Types of Intracranial Injury
Abstract:

 The most widely studied neuro-markers in traumatic brain injury (TBI) are S100B and neurone
 specific enolase (NSE). S-100B is localized in astroglia. This marker is used to predict
 neuronal damage caused by traumatic brain injury. The investigators conduct a study to derive
 and validate the measurement of S-100B in serum of patients with different types traumatic
 brain injuries.
The neuromarker S-100B is a well established tool for decision making in patients traumatic
 brain injury (TBI)in Europe. In many hospitals S-100B is used routinely as a part of a set of
 high- and medium risk factors aiding the decision to perform a cranial computed tomography
 (CCT) in patients with minor head injury (MHI). In patients with severe head injury Raabe et
 al. found a significant correlation between the S-100B levels and unfavourable outcome in
 patients with severe brain injury with serum levels higher than 0.50 μg/l measured 24h after
 injury. The average level of the neuromarker, compared with other studies. The study of
 Biberthaler et al. showed highest levels in patients with epidural hematomas, followed by
 subdural, subarachnoidal and intracerebral hematomas. On the contrary the average S-100B
 levels of patients with epidural hematomas featured in a study by Unden et al. published in
 2005 displayed normal levels (<0.2 μg/L). They concluded that S-100B was unreliable as a
 marker for epidural hematomas.

 Aim of the study Validation of S-100B in patients with intracerebral, epidural, subdural, and
 subarachnoidal hematoma, brain edema and concussion (Group 1-6), to find evidence which kind
 of injury leads to which level of elevation of the neuromarker measured in peripheral blood.
Inclusion Criteria:

 -  all patients with traumatic brain injury

 Exclusion Criteria:

 -  patients without traumatic brain injury