Intra-Articular Autologous Bone Marrow Mesenchymal Stem Cells Transplantation to Treat Mild to Moderate Osteoarthritis
Intra-Articular Autologous Bone Marrow Mesenchymal Stem Cells Transplantation to Treat Mild to Moderate Osteoarthritis
Osteoarthritis is a progressively degenerative disease resulting in increasing pain,
 impairment and ultimately disability. While the available treatments seek to ameliorate pain
 or improve mobility, these treatments rarely modify the course of the disease, but rather
 attend to its consequences. For early stage osteoarthritis, treatment is largely limited to
 addressing the symptoms of inflammation with non-steroidal anti-inflammatory drugs (NSAIDs).
 These drugs do not stop the progression of the condition or regenerates damaged cartilage.

 This is a randomized and open labelled study aimed to determine the efficacy of
 intra-articular implantation of autologous bone marrow-derived mesenchymal stem cells in
 patients with mild to moderate osteoarthritis.
Inclusion Criteria:

 -  Diagnosed with mild to moderate osteoarthritis based on Kellgren-Lawrence radiographic
 classification

 -  Has a history of joint swelling, pain, stiffness, altered gait and loss of motion due
 to degenerative cartilage

 Exclusion Criteria:

 -  Has systemic bone or cartilage disorders

 -  Has significant vascular impairment proximal to implant site

 -  Has substantial joint destabilization including extensive osteophyte formation

 -  Has substantial surface erosion of the weight-bearing articular cartilage

 -  Evidence of infection or fractures in or around the joint

 -  Contraindication to bone marrow aspiration

 -  Any acute or chronic communicable diseases including Hepatitis B, Hepatitis C and HIV

 -  Any past history of neoplasia and primary hematological disease

 -  Renal impairment indicated by serum creatinine greater than 200mM

 -  Liver impairment indicated by serum aspartate transaminase and serum alanine
 transaminase greater than 120 IU

 -  Any other co-morbidity which the physician deems as a contraindication to stem cell
 transplantation and bone marrow biopsy