Study of ENMD-2076 in Patients With Multiple Myeloma
Study of ENMD-2076 in Patients With Multiple Myeloma
The study is designed to assess the safety, tolerability, maximum tolerated dose, and
 clinical benefit of treatment with ENMD-2076 administered orally once daily over a range of
 doses in patients with relapsed or refractory multiple myeloma.
Major Inclusion Criteria:

 1. Histological evidence of MM and evidence of relapse or refractory disease. Patients
 with non secretory myeloma or plasmacytoma only will be excluded.

 2. Patients must have failed thalidomide, lenalidomide, or velcade or be intolerant or
 ineligible to receive these agents.

 3. Age ≥18 years.

 4. ECOG performance status 0-2.

 5. Patients must have adequate organ and marrow function

 Major Exclusion Criteria:

 1. Prior cytotoxic chemotherapy or investigational agent within 28 days or autologous
 stem cell transplant within 6 months of receiving study drug ENMD-2076.

 2. Prior radiation therapy to > 25% of bone marrow forming bones (i.e., pelvis).

 3. Concomitant corticosteroid therapy in doses greater than 10 mg daily of prednisone (or
 equivalent) if given for management of co-morbid conditions.

 4. Have unstable angina pectoris or recent myocardial infarction (within 6 months.

 5. Have uncontrolled hypertension or congestive heart failure.