Cabozantinib and Erlotinib for Patients With EGFR and c-Met Co-expressing Metastatic Pancreatic Adenocarcinoma
Cabozantinib and Erlotinib for Patients With EGFR and c-Met Co-expressing Metastatic Pancreatic Adenocarcinoma
This is an open-label, single arm, phase II trial. Safety will be monitored on an ongoing
 basis. Laboratory testing (chemistry, hematology tests) will be performed every 2 weeks for
 the first 8 weeks followed by assessments every 4 weeks. Other safety evaluations including
 EKGs, urinalysis, coagulation and thyroid function studies will be performed at regular
 intervals.

 Adverse event seriousness, severity grade, and relationship to study treatment will be
 assessed by the investigator. Severity grade will be defined by the National Cancer Institute
 (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 4.03.

 Tumors will be assessed by contrast enhanced CT or MRI every 8 weeks. Pre-treatment tissue
 will be obtained via CT-guided FNA biopsy or collected during resection. However, archival
 tissue will also be requested, when available and if adequate for testing. Post-treatment
 tissue will be obtained on Day 15 (i.e., Week 3/Day 1) via CT-guided FNA biopsy. All tumor
 tissue from eligible patients will be utilized for the correlative studies which are outlined
 in this trial.

 Each subject's course will consist of three periods:

 -  A Pre-Treatment Period in which subjects are consented and undergo screening assessments
 to be qualified for the study;

 -  A Treatment Period in which subjects receive study treatment and undergo study
 assessments. Patients who meet the eligibility criteria will be treated with
 cabozantinib orally at 40 mg daily and erlotinib orally at 100 mg daily without breaks;

 -  A Post-Treatment Period in which subjects no longer receive study treatment but undergo
 follow-up study assessments and contacts.
Primary Objective The primary objective of this trial is to demonstrate a radiographic
 response rate of 15% or greater for the combination in a selected population.

 Secondary Objectives

 The secondary objectives of this trial are:

 -  To estimate progression-free survival (PFS), objective response rate (ORR), disease
 control rate (DCR), overall survival (OS); and

 -  To assess safety and tolerability of this combination in the target patient population.

 Correlative Objectives

 The following tests will be performed on blood and tumor tissue samples collected during this
 trial to correlate with PFS and OS:

 -  c-Met and EGFR mRNA by RT-qPCR

 -  plasma HGF and soluble Met receptor

 -  c-Met and EGFR phosphoprotein levels by IHC

 -  KRAS mutation status
Inclusion Criteria

 A subject must fully meet all of the following criteria to be eligible for the study:

 1. The subject has a biopsy-proven diagnosis of adenocarcinoma of the pancreas (or
 recurrence of previously resected disease) with metastatic disease that is measurable
 per RECIST 1.1;

 2. The subject must have tumor that is amenable to fine needle biopsy via computerized
 tomography (CT) guided approach OR an archived tissue sample such as a prior surgical
 sample or biopsy sample that is adequate for testing;

 3. The subject must have EGFR and c-Met overexpressed in tumor as determined by
 immunohistochemistry (IHC) test score of 2+ for both markers;

 4. The subject has demonstrated radiographic progression after front-line treatment for
 locally advanced or metastatic disease (prior adjuvant therapy allowed if ≥ 6 months
 elapsed between end of adjuvant therapy and metastatic relapse);

 5. The subject is ≥ 18 years old on the day of consent;

 6. The subject has an Eastern Cooperative Oncology Group (ECOG) performance status of 0
 or 1;

 7. The subject has recovery to baseline or ≤ Grade 1 CTCAE v.4.03 from toxicities related
 to any prior treatments, unless AE(s) are clinically nonsignificant and/or stable on
 supportive therapy;

 8. The subject has organ and marrow function and laboratory values as follows within 7
 days before the first dose of study treatment:

 1. The ANC ≥ 1500/mm3 without colony stimulating factor support;

 2. Platelets ≥ 100,000/mm3;

 3. Hemoglobin ≥ 9 g/dL;

 4. Bilirubin ≤ 1.5 x the ULN. For subjects with known Gilbert's disease, bilirubin ≤
 3.0 mg/dL;

 5. AST/ALT ≤ 3 x the ULN;

 6. Serum albumin ≥ 2.8 g/dl;

 7. Serum creatinine ≤ 1.5 x the ULN or creatinine clearance (CrCl) ≥ 40 mL/min. For
 creatinine clearance estimation, the Cockcroft and Gault equation should be used:

 i. Male: CrCl (mL/min) = (140 - age) × wt (kg) / (serum creatinine × 72); ii. Female:
 Multiply above result by 0.85; h. UPCR ≤ 1; i. Serum phosphorus, calcium, magnesium
 and potassium ≥ LLN; j. Prothrombin time (PT)/INR or partial thromboplastin time (PTT)
 test < 1.3 x the ULN within 7 days before the first dose of study treatment;

 9. The subject is capable of understanding and complying with the protocol requirements
 and has signed the informed consent document;

 10. The subject has a life expectancy of 12 weeks or greater;

 11. The subject is able to tolerate oral medications and no evidence of ongoing
 malabsorption;

 12. All sexually active subjects of reproductive potential must agree to use both a
 medically accepted barrier method (e.g., male or female condom) and a second method of
 birth control during the course of the study and for 4 months after the last dose of
 study drug(s);

 13. Female subjects of childbearing potential must not be pregnant at screening. Females
 of childbearing potential are defined as premenopausal females capable of becoming
 pregnant (i.e., females who have had any evidence of menses in the past 12 months,
 with the exception of those who had prior hysterectomy or bilateral oophorectomy).
 However, women who have been amenorrheic for 12 or more months are still considered to
 be of childbearing potential if the amenorrhea is possibly due to prior chemotherapy,
 antiestrogens, low body weight, ovarian suppression or other reasons.

 Exclusion Criteria

 A subject who meets any of the following criteria is ineligible for the study:

 1. The subject has received cytotoxic chemotherapy (including investigational cytotoxic
 chemotherapy) or biologic agents (e.g., cytokines or antibodies) within 3 weeks, or
 nitrosoureas/mitomycin C within 6 weeks before the first dose of study treatment;

 2. Prior treatment with cabozantinib or erlotinib;

 3. Radiation therapy for bone metastasis within 2 weeks, any other external radiation
 therapy within 4 weeks before the first dose of study treatment. Systemic treatment
 with radionuclides within 6 weeks before the first dose of study treatment. Subjects
 with clinically relevant ongoing complications from prior radiation therapy are not
 eligible;

 4. Receipt of any type of small molecule kinase inhibitor (including investigational
 kinase inhibitor) within 14 days before the first dose of study treatment;

 5. The subject has received any other type of investigational agent within 28 days before
 the first dose of study treatment;

 6. Known brain metastases or cranial epidural disease unless adequately treated with
 radiotherapy and/or surgery (including radiosurgery) and stable for at least 4 weeks
 before the first dose of study treatment. Eligible subjects must be neurologically
 asymptomatic and without corticosteroid treatment at the time of the start of study
 treatment;

 7. Concomitant anticoagulation at therapeutic doses with oral anticoagulants (e.g.,
 warfarin, direct thrombin and Factor Xa inhibitors) or platelet inhibitors (e.g.,
 clopidogrel); Note: Low-dose aspirin for cardioprotection (per local applicable
 guidelines) and low-dose LMWH are permitted. Anticoagulation with therapeutic doses of
 LMWH is allowed in subjects who are on a stable dose of LMWH for at least 6 weeks
 before first dose of study treatment, and who have had no clinically significant
 hemorrhagic complications from the anticoagulation regimen or the tumor.

 8. The subject has experienced any of the following:

 1. clinically-significant GI bleeding within 6 months before the first dose of study
 treatment;

 2. hemoptysis of ≥ 0.5 teaspoon (2.5ml) of red blood within 3 months before the
 first dose of study treatment;

 3. any other signs indicative of pulmonary hemorrhage within 3 months before the
 first dose of study treatment; and

 4. clinically confirmed history of interstitial lung disease (ILD).

 9. The subject has radiographic evidence of cavitating pulmonary lesion(s);

 10. The subject has tumor invading or encasing any major blood vessels;

 11. The subject has evidence of tumor invading the GI tract (esophagus, stomach, small or
 large bowel, rectum or anus), or any evidence of endotracheal or endobronchial tumor
 within 28 days before the first dose of cabozantinib;

 12. The subject has uncontrolled, significant intercurrent or recent illness including,
 but not limited to, the following conditions:

 a. Cardiovascular disorders including: i. Congestive heart failure (CHF): New York
 Heart Association (NYHA) Class III (moderate) or Class IV (severe) at the time of
 screening; ii. Concurrent uncontrolled hypertension defined as sustained blood
 pressure (BP) > 150 mm Hg systolic or > 100 mm Hg diastolic despite optimal
 antihypertensive treatment within 7 days of the first dose of study treatment; iii.
 Any history of congenital long QT syndrome; iv. Any of the following within 6 months
 before the first dose of study treatment:

 -  unstable angina pectoris;

 -  clinically-significant cardiac arrhythmias;

 -  stroke (including transient ischemic attack (TIA), or other ischemic event);

 -  myocardial infarction. b. GI disorders particularly those associated with a high
 risk of perforation or fistula formation including: i. Tumors invading the GI
 tract, active peptic ulcer disease, inflammatory bowel disease (e.g., Crohn's
 disease), diverticulitis, cholecystitis, symptomatic cholangitis or appendicitis,
 acute pancreatitis or acute obstruction of the pancreatic duct or common bile
 duct, or gastric outlet obstruction ii. Abdominal fistula, GI perforation, bowel
 obstruction, intra-abdominal abscess within 6 months before first dose of study
 treatment Note: Complete healing of an intra-abdominal abscess must be confirmed
 prior first dose of study treatment c. Other clinically significant disorders
 that would preclude safe study participation;

 13. Major surgery within 12 weeks before the first dose of study treatment. Complete wound
 healing from major surgery must have occurred 1 month before the first dose of study
 treatment. Minor surgery (including uncomplicated tooth extractions) within 28 days
 before the first dose of study treatment with complete wound healing at least 10 days
 before the first dose of study treatment. Subjects with clinically relevant ongoing
 complications from prior surgery are not eligible;

 14. QTcF > 500 msec within 1 month before the first dose of study treatment:

 a. Three ECGs must be performed for eligibility determination. If the average of these
 three consecutive results for QTcF is ≤ 500 msec, the subject meets eligibility in
 this regard.

 15. Pregnant or lactating females;

 16. Active smoker;

 17. Inability to swallow intact tablets;

 18. Previously identified allergy or hypersensitivity to components of the study treatment
 formulations;

 19. Diagnosis of another malignancy within 2 years before the first dose of study
 treatment, except for superficial skin cancers, or localized, low grade tumors deemed
 cured and not treated with systemic therapy; malignancy felt by investigator to
 potentially affect subject survival or ability to evaluate disease response.