Bone Healing Study
Bone Healing Study
The aim of the research is to identify structural tissue changes in the early fracture
 hematomas.
The fracture hematomas obtained during reconstructive bone surgery from patients with bone
 fractures will be examined. Histological methods and ultra-thin sections for electron
 microscopy will be used to identify structural tissue changes in the granulation tissue in
 different period of time after bone fracture. Immunohistochemical analysis will be performed
 to estimate the dynamic of proliferation, differentiation and cell migration during
 granulation and reticulofibrosis bone tissues development.
Inclusion Criteria:

 -  Patients with fractures of the upper and lower extremities

 -  Patients for whom the surgical bone reconstruction are indicated