Systemic Lupus Erythematosus Exercise Program
Systemic Lupus Erythematosus Exercise Program
This pilot study is a randomized controlled trial to assess the effect of an individualized
 supervised exercise program in patients with systemic lupus erythematosus (SLE) compared to
 treatment-as-usual (TAU).
The aim of this study is to evaluate the effect of a 12-week individualized exercise program
 in subjects with SLE in comparison to treatment-as-usual therapy. Several previous studies
 showed that exercise leads to various benefits in treating SLE, including enhanced aerobic
 capacity, reduced symptoms of depression and fatigue. Moreover, it has been shown that
 exercise is well tolerated and does not impair disease activity in SLE negatively. Here, the
 effects of an individual internet-based exercise therapy for 12 weeks will be evaluated.
Inclusion Criteria:

 -  Positive ANA-titer (≥ 1:80) or Anti-dsDNA (≥ 200 IU/ml) or Highly avid-dsDNA
 autoantibody (≥ 30 IU/ml)

 -  Stable immunosuppressive therapy more than 30 days before beginning of the study with
 steroid (0-20 mg/day) or other immunosuppressive medication like Hydroxchloroquin,
 Chloroquin, Azathioprin, Methotrexat, Mycophenolatmofetil, Cyclosporin, Belimumab,
 Rituximab

 Exclusion Criteria:

 -  Pregnancy, Active lupus nephritits, Physical activity more than two times a week