Study of Metabolism and Cardiovascular Disease(CVD) in Women With Polycystic Ovary Syndrome (PCOS)
Study of Metabolism and Cardiovascular Disease(CVD) in Women With Polycystic Ovary Syndrome (PCOS)
PCOS is the most common endocrine disorder in reproductive women. It is estimated that 5 to
 10% of women of reproductive age have PCOS. One of the major diagnostic criteria of PCOS was
 chronic anovulation which lead to irregular menstruation, amenorrhea, and infertility; the
 other diagnostic criteria was hyperandrogenism which lead to hirsutism, acne and alopecia.
 Furthermore, PCOS is thought as a metabolic disorder, the long-term consequence of PCOS were
 diabetes mellitus and cardiovascular disease, which are potentially dangerous in women
 health. Early diagnosis and prevention is very important to the PCOS patients.

 Obesity is the most potential risk of threat to health of populations. There is a major
 impact of obesity on the PCOS related disorders. Insulin resistance and distribution of
 adipose tissue were thought to be the important risk factors of cardiovascular and metabolic
 syndrome.

 To treat PCOS patients properly,Wan-Fang hospital had established a specific medical team.
 The investigators recently published in "Fertility and Sterility" about the clinical
 presentation of androgen excess in Taiwanese women. Hirsutism is much less prevalence in
 Taiwanese PCOS women than that previous reported in the Western women. It is important to
 know that some clinical presentation of PCOS might have ethic variance. Insulin resistance
 was reported as another candidate that might have ethic variance.The investigators had
 reported about 40% women in PCOS women were obese, it is similar with previous literature
 reported. Obesity is a major factor that could be controlled during the treatment of
 PCOS.Weight reduction is one of our methods in PCOS treatment. The progressive results for
 obese PCOS women would be facing the risks of diabetes and metabolic syndrome.The
 investigators thought like to evaluate the benefit of weight reduction program to the
 prognosis of obese women with PCOS. Furthermore, it is known that Endothelial progenitor
 cells (EPC) be an early marker of cardiovascular disease, the investigators would like to
 know the role of EPC to predict metabolic syndrome in women with PCOS. Wan-Fang hospital has
 a professional team in PCOS treatment and research which including gynecological
 endocrinologist, cardiologist, medical endocrinologist, specialist in weight reduction. This
 team had been working well for more that 4 years.

 The investigators hope that they can make a contribution to the study and treatment of PCOS
 in Taiwan.
Inclusion Criteria:

 -  PCOM by ultrasound Diagnosis

 -  Anovulation, Oligo menses

 -  Hyperandrogenism

 Exclusion Criteria:

 -  Women who had been diagnosed with other etiology that should be excluded in PCOS
 diagnosis, such as hyperprolactinemia, hypogonadotropic hypogonadism, premature
 ovarian failure, congenital adrenal hyperplastic, androgen-secreting tumor, Cushing's
 syndrome, disorders of uterus (such as Asherman's syndrome, Mullerian agenesis),
 chromosomal anomalies (such as Turner syndrome).

 -  Women who did not have sufficient clinical or biochemical records.

 -  Girls who had menarche at <3 years of age and women who were >40 years of age.