Insulin Action in Individuals With Type 2 Diabetes by Natural Fatty Acids or the Medication Pioglitazone
Insulin Action in Individuals With Type 2 Diabetes by Natural Fatty Acids or the Medication Pioglitazone
The purpose of this study is to investigate the changes in insulin (a hormone produced in the
 body by the pancreas that regulates the amount of sugar in the blood) action and adiponectin
 (a protein hormone which regulates sugar levels and fatty acid breakdown) levels after giving
 individuals with type 2 diabetes a medication, pioglitazone, for three weeks.
Participants in this study will be given a 21 day supply of either pioglitazone (a medication
 used to treat diabetes) or a placebo. Changes to the body's response to insulin in the liver
 and in peripheral tissues (eg, muscle and fat) will be measured using a procedure called a
 pancreatic clamp. During the clamp procedure, glucose (a sugar) and insulin are infused with
 an intravenous catheter, and blood samples are collected periodically throughout the
 procedure to measure blood sugar levels and the levels of several hormones that are found in
 the body and are related to glucose metabolism. Small amounts of muscle and fat tissue will
 also be taken during this study to measure changes in gene expression after taking the
 medication/placebo for 3 weeks.
Inclusion Criteria:

 -  Individuals with Type 2 Diabetes

 -  HbA1c over 8%

 Exclusion Criteria:

 -  Individuals with bleeding disorders including GERD, PUD, any GI bleeding

 -  High blood pressure

 -  History of Coronary Artery Disease or exertional chest pain