Cognitive Function After Radiation Therapy for Brain Tumours
Cognitive Function After Radiation Therapy for Brain Tumours
This study will assess cognitive function in adult patients with a primary brain tumour
 treated with surgical resection with or without radiation therapy (RT). All types of brain
 tumours apart from glioblastoma will be included
RT to brain tumours causes cognitive dysfunction. The extent of RT induced changes in
 cognitive function and radio-sensitivity of the brain is unknown. RT with protons instead of
 photons spares the healthy brain tissue more and is believed to reduce the risk of cognitive
 dysfunction. There is modest knowledge on which parts of the brain the investigators need to
 spare, to prevent cognitive dysfunction.

 The study is a cross sectional study assessing cognitive function in patients with brain
 tumours previously treated with RT compared to a similar non irradiated group. 104 patients
 with specified brain tumours from Aarhus University Hospital treated in the period 2006-2016
 will be included. The patients will do patient reported outcome (PRO) and undergo
 neuropsychological assessment with standardized tests: They will do this prior to RT
 treatment and ½, 1, 3 and 5 years afterwards. The PRO's included measures on quality of life,
 fatigue, sleep, depression, anxiety, and socio demografica. The standardized tests are: Trail
 making Test (TMT); Hopkins Verbal Learning Test (HVLT); Controlled Oral Word Association Test
 (COWAT) - Animals and S; Coding and Digit Span from WAIS-IV; Paced Auditory Serial Addition
 Test (PASAT). The correlation between cognitive scores and RT dose-volume parameters to
 specific areas in the brain will be tested.
Inclusion Criteria:

 -  The participant must be 18 years or older and Danish speaking.

 -  Performance status 0-2

 -  Capable of cooperating on testing

 -  Diagnosed with one of the following diagnoses according to WHO 2016 classification 16
 and been treated between 2006 and 2016

 1. ZM93803 glioma (exclusive glioblastoma)

 2. ZM9401/3 anaplastic astrocytoma, IDH mutant

 3. ZM9400/3 diffuse astrocytoma, IDH-mutant

 4. ZM9411/3 gemistocytisk astrocytoma, IDH mutant

 5. ZM9400/3 diffuse astrocytoma, NOS

 6. ZM9451/3 anaplastic oligodendroglioma, IDH mutant and 1p/19q-co deleted

 7. ZM9450/3 oligodendroglioma, IDH mutant and 1p/19q-co deleted

 8. ZM9450/3 oligodendroglioma, NOS

 9. ZM9451/3 anaplastic oligodendroglioma, NOS

 10. ZM9530/0 meningioma

 11. ZM9470/3 medulloblastoma, NOS

 12. DD352A pituitary adenoma

 13. Other rare brain tumours including skull base sarcomas

 -

 Exclusion Criteria:

 Performance status 3-4 Progression after radiation therapy

 -