Effects of L-thyroxine Replacement on Serum Lipid and Atherosclerosis in Hypothyroidism
Effects of L-thyroxine Replacement on Serum Lipid and Atherosclerosis in Hypothyroidism
Hypothyroidism is a common clinical entity which is often complicated by dyslipidemia. It is
 also reported increased risk for incidence of atherosclerosis and resulting coronary heart
 disease(CHD), heart failure(HF) and cardiovascular(CV) death. The effect of L-thyroxine
 replacement treatment on serum lipid and atherosclerosis is controversial in hypothyroid
 patients, especially in those with mild or moderate subclinical hypothyroidism. The present
 study was designed to investigate whether L-thyroxine replacement was effective in improving
 serum lipid profiles and retarding atherosclerosis progress.
Inclusion Criteria:

 -  40~75 years old

 -  Diagnosis of overt or subclinical hypothyroidism in two occasions with a minimum
 interval period of three months

 Exclusion Criteria:

 -  Pregnant or lactating women

 -  Severe hepatic or renal dysfunction

 -  Psychiatric disabilities, acute cardiovascular and cerebrovascular diseases, chronic
 respiratory diseases, familiar hypercholesterolemia, malignancy, cholelithiasis,
 pancreatitis, bowel diseases and other disorders influencing lipid and bile acid
 metabolism

 -  Taking lipid-lowering agents and other drugs influencing thyroid function, lipid and
 bile acid metabolism

 -  Obviously poor compliance.