An Epidemiological Study of Subjects With Immune Thrombocytopenic Purpura to Evaluate the Relationship Between Platelet Counts, Endogenous Thrombopoietin Levels, Endogenous Anti-Thrombopoietin Antibodies, and Selected Autoimmune Markers
An Epidemiological Study of Subjects With Immune Thrombocytopenic Purpura to Evaluate the Relationship Between Platelet Counts, Endogenous Thrombopoietin Levels, Endogenous Anti-Thrombopoietin Antibodies, and Selected Autoimmune Markers
This study involves the collection of blood samples from patients with immune
 thrombocytopenic purpura (ITP) to evaluate the relationship between platelet counts, blood
 levels of a hormone called thrombopoietin that controls platelet production by the bone
 marrow, and blood levels of antibodies against thrombopoietin that could interfere with the
 action of this hormone. Blood samples will also be stored if separately agreed to by the
 patient for analysis of genes that might affect platelet production. At a single outpatient
 clinic visit, patients will have a medical history taken, and blood samples drawn for
 testing. Results from this study may help further understand the control of platelet
 production in patients with ITP, and suggest new therapeutic approaches.
This study involves the collection of blood samples from patients with immune
 thrombocytopenic purpura (ITP) to evaluate the relationship between platelet counts, blood
 levels of a hormone called thrombopoietin that controls platelet production by the bone
 marrow, and blood levels of antibodies against thrombopoietin that could interfere with the
 action of this hormone. Blood samples will also be stored if separately agreed to by the
 patient for analysis of genes that might affect platelet production. At a single outpatient
 clinic visit, patients will have a medical history taken, and blood samples drawn for
 testing. Results from this study may help further understand the control of platelet
 production in patients with ITP, and suggest new therapeutic approaches.
Diagnosis of ITP, based on the history, physical examination, complete blood count, and
 examination of the peripheral smear, which should exclude other causes of thrombocytopenia.
 These criteria for ITP are based on the American Society of Hematology practice guideline
 for ITP.

 Subjects 5 years of age or older.

 Before the study specific procedure, the subject or legally acceptable representative must
 give written informed consent(s) for participation in the study.

 No subjects with documented history of Human Immunodeficiency Virus (HIV) or Hepatitis.

 No subjects with known underlying causes of thrombocytopenia such as lupus erythematosus,
 autoimmune thyroid disorders, drug-induced thrombocytopenia, bone marrow disorders, and
 liver disease.

 No psychiatric or addictive disorders that compromise the subject's ability to give truly
 informed consent for participation in the study.