SEEG Investigation of Mood Dysregulation in Epilepsy
SEEG Investigation of Mood Dysregulation in Epilepsy
Using the novel analysis of stereo-electroencephalography (SEEG) recordings, this proposal
 will investigate the activity and connectivity of mood regulation circuits in subjects with
 suspected epileptic focus who have undergone SEEG electrode implantation for monitoring of
 seizure activity.
It is well known that epilepsy is associated with mood dysregulation including symptoms of
 labile mood, impulse control problems, anxiety, depression and increase in incidence of
 suicide. However, until present the neurobiological basis of mood dysregulation in epilepsy
 has not been clear and has been mostly attributed to a psychological reaction to the illness.
 This has severely limited our understanding of the impairments in mood regulation that people
 with epilepsy often experience and has also limited the development of effective treatment
 for ameliorating psychosocial dysfunction in people with epilepsy. The identification of
 these circuits will not only increase our understanding of mood-regulation in epilepsy but
 also possibly provide biomarkers with which the effectiveness of new treatments can be
 investigated. Developing better diagnostic measures and treatments for mood dysregulation
 will be highly beneficial to the quality of life of subjects suffering from epilepsy.
Inclusion Criteria:

 -  Subjects will be a part of the epilepsy-monitoring unit for long-term SEEG recordings
 and analysis

 Exclusion Criteria:

 -  Subjects that experience surgical complications during the implant procedure will be
 excluded from the study