Adherence of Stalevo, Entacapone and Levodopa
Adherence of Stalevo, Entacapone and Levodopa
To test if combining two antiparkinson drugs into a single tablet improves accuracy of
 medicine intake by the patient.

 To test if patients with Parkinson's disease who take medicines at regular time intervals
 have smoother symptom control.
Inclusion Criteria:

 -  Patients diagnosed with Parkinson's disease aged between 18 and 85 years fulfilling UK
 Brain Bank criteria.

 -  Current levodopa therapy prescribed on a regular basis three or more times per day but
 requiring entacapone because of 'wearing off'

 -  Able to manipulate electronic monitoring bottles and complete questionnaires

 Exclusion Criteria:

 -  Current use of compliance aid such that study participation would be detrimental to
 patient's adherence

 -  Pregnancy or breast feeding

 -  Excess alcohol (over 21 units per week for women and 28 units for men)

 -  Mini mental state examination of less than 26.

 -  Severe depression (Geriatric depression score over 20)