The Impact of a Home-based Pulmonary Telerehabilitation Program in Acute Exacerbations of COPD
The Impact of a Home-based Pulmonary Telerehabilitation Program in Acute Exacerbations of COPD
COPD impacts a significant proportion of the Veteran population. Acute exacerbations, or
 flare-ups, of COPD are associated with impaired muscle function and worse quality of life.
 Pulmonary rehabilitation, a formal exercise program for patients with lung disease that
 includes both endurance and strength training exercises, has been shown to improve muscle
 function and quality of life after an acute exacerbation of COPD. However, lack of
 geographically accessible rehabilitation facilities and/or transportation issues are often
 barriers to pulmonary rehabilitation attendance in the Veteran population. This study will
 assess the feasibility and impact of an eight-week, three sessions per week, home-based,
 pulmonary telerehabilitation program in Veterans with COPD following hospitalization for an
 acute exacerbation of their lung disease. We will measure adherence and satisfaction with the
 program and muscle strength, physical activity, quality of life, and exercise tolerance pre
 and post-intervention in Veterans randomized to the pulmonary telerehabilitation arm versus
 Veterans randomized to the control arm who do not participate in pulmonary rehabilitation.
Pulmonary telerehabilitation programs have been shown to have a high acceptance and adherence
 rate and lead to improvement in exercise capacity and quality of life in stable COPD.
 However, data regarding the feasibility and impact of pulmonary telerehabilitation following
 hospitalization for an Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD)
 on physical activity levels, muscle function, exercise capacity, and health-related quality
 of life are lacking. The primary hypothesis is that a home-based pulmonary telerehabilitation
 program initiated at hospital discharge following an AECOPD is feasible in the Veteran
 population and will result in increased physical activity and greater improvement in muscle
 function, exercise capacity, and health-related quality of life compared to usual care. This
 hypothesis will be tested with the following specific aims: (1) To determine the feasibility
 of an eight-week home-based pulmonary telerehabilitation program in Veterans with moderate to
 severe COPD initiated in the immediate post-hospitalization period following an AECOPD. (2)
 To determine physical activity levels and the magnitude and variability in changes of
 measurements of muscle strength, functional exercise performance, and health-related quality
 of life following an eight-week home-based pulmonary telerehabilitation program versus usual
 care initiated in Veterans with moderate to severe COPD immediately following hospitalization
 for an AECOPD. The study will randomize (1:1 allocation) 30 male and female Veterans
 hospitalized with an AECOPD to either an eight-week, three sessions per week, home-based
 pulmonary telerehabilitation program that includes lower extremity endurance exercises with a
 cycle ergometer and upper and lower extremity strength training with 1:1 supervision via
 video conferencing with an exercise physiologist as well as a twice-monthly online support
 group via video conferencing versus usual care. Changes from baseline in physical activity
 levels, handgrip and quadriceps muscle strength, exercise endurance, and health-related
 quality of life will be assessed following the pulmonary telerehabilitation program versus
 usual care. Findings from this project will contribute to the growing field of pulmonary
 telerehabilitation and will provide critical preliminary data for the design and
 implementation of a larger, randomized control trial assessing the impact of pulmonary
 telerehabilitation on long-term clinical outcomes following AECOPD.
Inclusion Criteria:

 -  Veterans

 -  Moderate or severe COPD with a forced expiratory volume in 1 second - forced vital
 capacity ratio (FEV1/FVC) < 0.70 and FEV1 < 80% predicted

 -  Hospitalization with a primary diagnosis of AECOPD, defined as an increase in
 shortness of breath, cough, and/or sputum production beyond the normal day-to-day
 variation necessitating a change in regular medication when other causes of increased
 shortness of breath, cough, and/or sputum production have been ruled out

 -  Capable of operating a tablet independently with adequate vision and hearing

 Exclusion Criteria:

 -  Acute hypercapneic respiratory failure with a requirement for either non-invasive
 (i.e. bilevel positive airway pressure) or invasive mechanical ventilation during
 hospitalization

 -  Hospitalization < 72 hours

 -  A secondary diagnosis of acute congestive heart failure, myocardial infarction, or
 pneumonia during hospitalization or unstable cardiac or neurologic disease at
 discharge

 -  Enrollment in a pulmonary rehabilitation program within 12 months of hospitalization

 -  A medical condition that makes exercise unsafe (includes upper and lower limb strength
 training and lower limb cycle ergometry)

 -  This will be determined by the following- screen for these through chart review,
 discussion with the patient (do they have any known cardiac issues, do they have
 chest pain with exertion, are they lightheaded with exertion), discussion with
 the physicians caring for the patient in the hospital, and direct observation and
 assessment during the bedside pulmonary rehab sessions (that were built into this
 study for safety purposes)

 -  Inclusion in another greater than minimal risk study