The Efficacy and Safety of Entecavir Treatment of Patients With Acute on Chronic Hepatitis B Liver Failure
The Efficacy and Safety of Entecavir Treatment of Patients With Acute on Chronic Hepatitis B Liver Failure
To evaluate therapeutic efficacy and predicting factors of entecavir for treating patients
 with acute on chronic hepatitis B liver failure (ACHBLF). A total of 108 patients with ACHBLF
 were allocated into either a treatment group (ETV group, n=53) or a control group (n=55). The
 HBV DNA level, liver function and survival condition of the patients were observed for 48
 weeks after enrollment. The factors possibly related to entecavir treatment efficacy were
 also identified.
Inclusion Criteria:

 -  ACHBLF was diagnosed according to the criteria from the APASL in March 200815 and the
 program of Prevention and Cure for Viral Hepatitis and Liver Disease amended by the
 National Symposium on Viral Hepatitis and Liver Disease in September 2000.

 -  age >18 years

 -  HBV DNA > 3log10 copy/mL

 Exclusion Criteria:

 -  Pregnant or lactating women.

 -  Diagnosed or suspected as hepatic carcinoma patients.

 -  Cases with any serious disease besides CHB, including heart disease, immunologic
 disease, malignant tumor, etc.

 -  Patients hypersensitive to nucleoside or nucleoside (acid) analogues or with a history
 nucleoside antiviral drug treatment.

 -  A history of drug abuse or alcohol abuse.

 -  Hepatic encephalopathy degree IV patients who were unable to take orally administered
 drugs.

 -  A history of using immunomodulator including steroids

 -  Conclusive evidence of other co infection s: anti-HAV-IgM positive, anti-HCV positive,
 anti-HEV positive, anti-HIV positive, autoimmunity liver diseases, Wilson disease,
 etc.