A Long Term Study of YM060 in Female Patients With Diarrhea-predominant Irritable Bowel Syndrome
A Long Term Study of YM060 in Female Patients With Diarrhea-predominant Irritable Bowel Syndrome
To evaluate the efficacy and safety of YM060 once daily for female patients with
 diarrhea-predominant irritable bowel syndrome (D-IBS) for a long-term period (up to 52
 weeks).
Inclusion Criteria:

 Female patients who meet the following criteria:

 1. Patients satisfying the Rome III Diagnostic Criteria

 2. Patients whose ≥25% of stools were loose or watery and <25% of them were hard or lumpy
 stools

 3. Patients who have abdominal pain or discomfort

 4. Patients in whom after occurrence of IBS symptoms the following tests were conducted
 and in whom no organic changes were observed Pancolonoscopy or contrast enema

 Exclusion Criteria:

 Patients who meet any of the following criteria:

 1. Patients with a history of surgical resection of the stomach,gallbladder, small
 intestine or large intestine

 2. Patients with a history or current evidence of inflammatory bowel disease

 3. Patients with a history or current evidence of colitis ischemic

 4. Patients with concurrent infectious enteritis

 5. Patients with concurrent hyperthyroidism or hypothyroidism

 6. Patients with concurrent active peptic ulcer

 7. Patients with other concurrent disease that may affect the digestive tract passage or
 large intestinal function or that is likely to interfere with proper assessment of IBS
 abdominal pain/discomfort