Validation of a Questionnaire for Allodynia in Migraine.
Validation of a Questionnaire for Allodynia in Migraine.
Migraine is very frequent (15% of the general population). During attacks, many subjects with
 migraine have allodynia (pain induced by normally non-painful stimuli), photophobia
 (hypersensitivity to light), phonophobia (hypersensitivity to sound) or osmophobia
 (hypersensitivity to odours). The goal of the present study is to validate a new
 questionnaire made of 4 parts evaluating the presence of these 4 types of hypersensitivity,
 both during or between migraine attacks. It will allow to look for associations of these 4
 symptoms and association of hypersensitivity with patients' or migraine's characteristics.
The prevalence of migraine is around 15% worldwide (GBD 2016, Lancet Neurol 2018). During
 attacks, and even between attacks, especially when migraine frequency is high, many subjects
 with migraine present with photophobia, phonophobia, osmophobia or allodynia. These symptoms
 are though to correspond to central sensitization and can be found in animal models of
 migraine (Boyer et al., Pain 2017; Dallel et al., Cephalalgia 2018).

 These 4 symptoms have been studied separately in previous studies but to date, there is no
 overall questionnaire evaluating these 4 sub-types of hypersensitivity. The investigators
 have constituted a questionnaire based on previous validated questionnaires that have been
 translated into French (Lipton et al., 2008 for cutaneous allodynia; Choi et al., 2009 for
 photophobia), a previous questionnaire validated in French (Khalfa et al, 2002 for
 phonophobia) and created a few questions for each of the 4 symptoms, including osmophobia.
Inclusion Criteria:

 -  Subjects fulfilling 2018 international headache society criteria for migraine.

 -  Age > 17 years.

 -  Written consent.

 Exclusion Criteria:

 -  Presence of neurological comorbidities that could lead to sensorial or sensitive
 abnormalities

 -  Presence of dermatological comorbidities that could lead to sensorial or sensitive
 abnormalities

 -  Presence of ENT comorbidities that could lead to sensorial or sensitive abnormalities

 -  Significant cognitive dysfunction precluding proper completion of the
 self-administered questionnaire