Temozolomide and Radiation Therapy in Treating Patients With Gliomas
Temozolomide and Radiation Therapy in Treating Patients With Gliomas
RATIONALE: Drugs used in chemotherapy, such as temozolomide, work in different ways to stop
 the growth of tumor cells, either by killing the cells or by stopping them from dividing.
 Radiation therapy uses high-energy x-rays to kill tumor cells. Giving temozolomide together
 with radiation therapy may kill more tumor cells.

 PURPOSE: This phase II trial is studying how well giving temozolomide together with radiation
 therapy works in treating patients with low-grade gliomas.
OBJECTIVES:

 -  Compare the 3-year survival of patients with high-risk low-grade gliomas treated with
 temozolomide and radiotherapy followed by temozolomide alone with that of patients
 enrolled on European Organization for Research and Treatment of Cancer (EORTC)clinical
 trials EORTC-22844 and EORTC-22845.

 -  Determine the toxicity of this regimen in these patients.

 -  Determine the association between progression-free survival and O6-methylguanine-DNA
 methyltransferase (MGMT) methylation status in patients treated with this regimen.

 -  Determine the association between survival and MGMT methylation status in patients
 treated with this regimen.

 -  Determine the quality of life (QOL) of patients treated with this regimen.

 -  Determine the neurocognitive function of patients treated with this regimen.

 -  Evaluate the feasibility of collecting patient-reported QOL and neurocognitive
 assessments over 3 years.

 OUTLINE: This is a non-randomized, multicenter study.

 Patients receive oral temozolomide once daily on days 1-42 and undergo radiotherapy once
 daily on days 1-5, 8-12, 15-19, 22-26, 29-33, and 36-40, one hour before RT weekdays, in the
 evening weekends. Beginning 28 days after completion of chemoradiotherapy, patients receive
 oral temozolomide once daily on days 1-5. Treatment with temozolomide repeats every 28 days
 for up to 12 courses in the absence of disease progression or unacceptable toxicity.

 Quality of life is assessed at baseline, 6 months, 12 months.

 After completion of study treatment, patients are followed at 4 months, every 6 months for 2
 years, and then annually thereafter.

 PROJECTED ACCRUAL: A total of 135 patients will be accrued for this study within 44 months.
DISEASE CHARACTERISTICS:

 -  Histologically confirmed* supratentorial glioma of 1 of the following histologies:

 -  Astrocytoma (diffuse fibrillary, protoplasmic, or gemistocytic)

 -  Oligodendroglioma

 -  Oligoastrocytoma Note: *Histologic atypia allowed provided no other histologic
 features (i.e., frequent mitoses, endothelial proliferation, and/or acute
 necrosis) that would result in a designation of anaplastic astrocytoma,
 anaplastic mixed oligodendroglioma or oligoastrocytoma, or glioblastoma
 multiforme are present

 -  Unifocal or multifocal disease

 -  World Health Organization (WHO) grade II disease

 -  Neurofibromatosis allowed

 -  Surgical biopsy or resection for tumor tissue sampling required within the past 12
 weeks

 -  Tissue block or core biopsy available for O6-methylguanine-DNA methyltransferase
 analysis and tissue banking

 -  Patients who have only had a stereotactic biopsy are not eligible

 -  Must have ≥ 3 of the following risk factors:

 -  Age 40 and over

 -  Largest preoperative tumor diameter ≥ 6 cm

 -  Tumor crosses the midline

 -  Astrocytoma-dominant tumor subtype

 -  Preoperative Neurological Function Status > 1

 -  No other low-grade glioma histologies, including any of the following:

 -  Pilocytic astrocytoma

 -  Subependymal giant cell astrocytoma of tuberous sclerosis

 -  Subependymoma

 -  Pleomorphic xanthoastrocytoma

 -  Presence of a neuronal element, such as ganglioglioma

 -  Dysneuroembryoplastic epithelial tumor

 -  No high-grade glioma, including any of the following:

 -  Anaplastic astrocytoma

 -  Glioblastoma multiforme

 -  Anaplastic oligodendroglioma

 -  Anaplastic oligoastrocytoma

 -  No tumors in any non-supratentorial location, including any of the following:

 -  Optic chiasm

 -  Optic nerve(s)

 -  Pons

 -  Medulla

 -  Cerebellum

 -  Spinal cord

 -  No evidence of disease progression to spinal meninges or noncontiguous cranial
 meninges (i.e., leptomeningeal gliomatosis) by MRI of the spine or cerebrospinal fluid
 (CSF) cytology

 -  MRI of the spine or CSF cytology are not required for patients without symptoms
 of spinal/cranial meningeal disease progression

 PATIENT CHARACTERISTICS:

 Age

 -  18 and over

 Performance status

 -  Zubrod 0-2

 Life expectancy

 -  Not specified

 Hematopoietic

 -  Absolute neutrophil count ≥ 1,500/mm^3

 -  Platelet count ≥ 100,000/mm^3

 Hepatic

 -  Total bilirubin ≤ 1.5 mg/dL

 -  Serum glutamate oxaloacetate transaminase (SGOT) or Serum glutamate pyruvate
 transaminase (SGPT) ≤ 2 times normal

 -  Alkaline phosphatase ≤ 2 times normal

 Renal

 -  Serum creatinine ≤ 1.5 mg/dL

 Other

 -  Not pregnant or nursing

 -  Negative pregnancy test

 -  Fertile patients must use effective contraception

 -  No known HIV positivity

 -  No other malignancy within the past 5 years except carcinoma in situ of the cervix or
 nonmelanoma skin cancer

 -  No active infection

 PRIOR CONCURRENT THERAPY:

 Biologic therapy

 -  No concurrent immunotherapy or biologic therapy

 Chemotherapy

 -  No prior chemotherapy

 -  No other concurrent chemotherapy

 Endocrine therapy

 -  Not specified

 Radiotherapy

 -  No prior radiotherapy to the head and neck unless head and neck radiotherapy clearly
 excluded the brain (e.g., localized radiotherapy to the vocal cords)

 -  No prior radiotherapy to the brain

 -  No concurrent intensity modulated radiotherapy

 -  No concurrent stereotactic boost radiotherapy

 Surgery

 -  See Disease Characteristics

 Other

 -  No other concurrent investigational agents