Use of Clarithromycin in Mustard-Induced Bronchiolitis
Use of Clarithromycin in Mustard-Induced Bronchiolitis
We looked for the effectiveness of low-dose long-term prescription of clarithromycin in
 mustard-induced chronic pulmonary lesions, especially bronchiolitis obliterans
Inclusion Criteria:

 -  His/her own will to participate

 -  Documented chemical exposure

 -  Clinical, spirometric and radiological findings were compatible with BO on High
 Resolution Computed Tomography (HRCT)

 Exclusion Criteria:

 -  any drug reactions during the trial

 -  history of sensitivity to macrolides

 -  diarrhea, gray stool, jaundice, eosinophilia, acute cholestatic hepatitis, pruritis,
 dark urine, abdominal pain, osteomatosis, depression, taste change, behavioural
 changes, early fatigue, odynophagia, glossitis , dizziness

 -  co-adminstration of: terfenadine, theophylline, carbamazepine, ergotamine,
 dihydroergotamine, warfarin, cisapride, digoxin, triazolam, phenytoin, steroids, any
 immunosuppressive, any systemic antibiotics

 -  using drugs that he/she cannot discontinue

 -  using drugs with potential interaction

 -  subject will to exit from the trial

 -  history of lobe resection of lung

 -  history of exacerbation in the last month prior to the beginning of trial

 -  continuous need to oxygen

 -  use of corticosteroids in last week prior to the trial beginning

 -  Radiographic evidence of pneumonia, active tuberculosis, lung carcinoma, or an
 infection that necessitated the use of an antibiotic

 -  exacerbating of subjects

 -  creatinine srum level more than normal

 -  increasing ALT, AST levels

 -  total bilirubin more twice than normal

 -  subjects who did not use their drugs properly