SEMA4C as a Relapse Biomarker in Breast Cancer
SEMA4C as a Relapse Biomarker in Breast Cancer
Breast cancer remains the most common cancer in women worldwide. Semaphorin4C (SEMA4C) has
 previously been identified as a highly expressed protein by breast cancer-associated
 lymphatic endothelial cells (LECs). The objective of this study is to investigate SEMA4C's
 potential role as an early relapse biomarker in breast cancer.
Breast cancer remains the most common cancer in women worldwide, with approximately 1.68
 million new cases, and 0.52 million deaths, annually. Meanwhile the incidence of breast
 cancer continues to increase. Although regular clinical examination, mammography,
 ultrasonography, and magnetic resonance imaging can detect some recurrence patients, the lack
 of robust biomarkers for monitoring of anti-tumor therapies and detection of recurrence
 reduce the treatment effectiveness of current strategies for breast cancer.

 Semaphorin4C (SEMA4C) has been previously identified as a highly expressed protein by breast
 cancer-associated lymphatic endothelial cells (LECs) using in situ laser capture
 microdissection of lymphatic vessels, followed by cDNA microarray analysis. Moreover,
 membrane-bound SEMA4C is cleaved by matrix metalloproteinase (MMPs) to release a soluble form
 of this protein. The study is undertaken to explore SEMA4C's potential role as an early
 relapse biomarker in breast cancer.
Inclusion Criteria:

 -  Have histologically confirmed new diagnosis of breast cancer according to biopsy or
 surgery

 Exclusion Criteria:

 -  Patients who are not mentally capable of giving written informed consent

 -  Serum samples doesn't qualified

 -  Patients who refuse follow-up on their conditions

 -  Patients with prior cancer history

 -  Patients with a diagnosis of other severe acute or chronic medical may increase the
 risk associated with study participation or may interfere with the interpretation of
 the study results and, in the judgement of the Investigator, would make the patient
 inappropriate for enrollment in this study