Effect of Vitamin D Supplementation on Blood Pressure and HbA1c Levels in Patients With T2D
Effect of Vitamin D Supplementation on Blood Pressure and HbA1c Levels in Patients With T2D
The effect of administration of vitamin D is tested on the long-term control of blood sugar
 (as measured by HbA1-c levels in blood) and mean blood pressure (as measured by 24 hour blood
 pressure profiles)in patients with stable type 2 diabetes mellitus
Inclusion criteria

 -  Men and women, ages ≥18 years

 -  Official diagnostic criteria for type 2 diabetes fulfilled in patients on any type of
 oral or parenteral glucose-lowering treatment

 -  Independent living at home

 -  On stable regimen of BP meds (if any) with BP well controlled and/or K supplement (if
 any) for 2 months and which is deemed unlikely to change during the study

 -  Stable glucose control for 2 months by any approved method including insulin

 Exclusion criteria

 -  Patients with type 1 diabetes (or insulin-requiring diabetes of unclear type)

 -  Patients on hemodialysis, with hyperparathyroidism or active cancer disease

 -  Patients with known metabolic bone disease

 -  Laboratory evidence of kidney (eGFR < 60 ml/min) or liver disease

 -  Dietary calcium intake exceeding 1500mg/d (as estimated by dietary history)

 -  25(OH) vitamin D levels at baseline > 70 nmol/L

 -  Calciuria (> 8 mmol/24 hours as measured by 24 hour urine collections)

 -  Hypo- and hypercalcemias and hypo- and hyperphosphatemias of any cause

 -  Medications that affect vitamin D metabolism (e.g. antiepileptic drugs, calcimimetics,
 1-34 PTH (Forsteo) vitamin D therapy over and above 400U daily 6 months prior to
 enrollment and during the study)

 -  Foreseeable need for adaptation of either glucose- or blood pressure lowering during
 the next 6 months as decided by the family physician or the treating diabetologist -
 see above

 -  History of binge eating or wt gain or loss exceeding 6 kg in past 18 months

 -  Patients on any type of inhibitors of plasma coagulation (i.e. coumarine, heparins)