Vitamin D Supplementation in Patients With Depression
Vitamin D Supplementation in Patients With Depression
Groups (intervention group receives 50000 IU vitamin D and control group receives placebo)
 through a random allocation. After 8 weeks, blood sample will be collected from each
 participant. The studied indices (inflammatory (IL-1β, IL-6, hs-CRP), PTH, platelet
 serotonin, serum oxytocin, serum 25(OH) D, depression status and anthropometry indices) will
 be evaluated at beginning and end of interventional period.
In this double-blind randomized clinical trial, 60 patients aged 18-60y referred to Baharlou
 hospital with a history of mild to moderate depression diagnosed by a psychiatrist will be
 presented to the researcher. After receipt of a signed informed consent form, eligible
 patients will participate. A general demographic questionnaire will be completed by an
 interviewer. Individuals are randomly divided into intervention and control groups. A 10-ml
 venous blood sample will be collected from each participant. The intervention group receives
 50000 IU of vitamin D every 2 weeks as vitamin D supplements for 8 weeks, provided monthly.
 The control group receives placebo. The drug schedule of both groups (if any) will be
 unchanged according to the prescribing physician. After 8 weeks, blood sample will be
 collected from each participant. The studied indices (inflammatory (IL-1β, IL-6, hs-CRP),
 PTH, platelet serotonin, serum oxytocin, serum 25(OH) D, depression status, anthropometry
 indices) will be evaluated at beginning and end of interventional period. Data will be
 analyzed by statistical tests.
Inclusion Criteria:

 -  age: 18 to 60 y

 -  Having mild to moderate depression

 Exclusion Criteria:

 -  Having a history of heart infarction

 -  Having a history of angina

 -  Having a history of stroke

 -  Having a history of kidney stones

 -  Having a history of high blood pressure (systolic blood pressure higher than 174 or
 diastolic blood pressure higher than 104 mm Hg)

 -  Having a history of liver disease

 -  Having a history of hyperparathyroidism

 -  Pregnancy and/or lactation

 -  Reproductive-aged women (under 50 years old) who are not receiving adequate
 contraception

 -  Consuming nutritional supplement containing vitamin D from 2 months ago

 -  Not willing to continue the study

 -  Failure to follow the Supplemental Program