Multicenter Retrospective Analysis About the Clinical Characteristics of Korean Paroxysmal Nocturnal Hemoglobinuria (PNH) Patients
Multicenter Retrospective Analysis About the Clinical Characteristics of Korean Paroxysmal Nocturnal Hemoglobinuria (PNH) Patients
Paroxysmal nocturnal hemoglobinuria (PNH) is a hematopoietic stem cell disorder in which
 unregulated activation of the complement system leads to significant ischemic morbidities
 with shortened lifespan. Life-threatening thromboembolism (TE) is the most feared
 complication of PNH, accounting for up to 45% of patient deaths. It is estimated that 40% of
 PNH patients experience a clinically evident TE and 60% of patients without clinically
 diagnosed TE demonstrate TE by high-sensitivity MRI, indicating the ongoing thrombotic risk
 in most patients with PNH. Much of these data come from PNH patients from European descent.
 To understand the impact of TE in patients with PNH from non-European regions, we performed
 this study to evaluate the clinical characteristics of Korean patients with PNH.
To evaluate the clinical characteristics in Korean PNH patients
Inclusion Criteria:

 -  Diagnosis confirmed by Ham's test or Flow cytometry Patients have any Flow cytometry
 data

 Exclusion Criteria:

 -  Patients have no Flow cytometry data