Assessment of Heterotopic Ossification of Elbow Joint in Relation of Serum Uric Acid.
Assessment of Heterotopic Ossification of Elbow Joint in Relation of Serum Uric Acid.
Heterotopic ossification (HO) is a common complication after surgical repair of elbow trauma.
 Uric acid is the end-product of purine metabolism that has any physiological and pathogenic
 potential functions. However, the relationship of HO and uric acid has not been explored up
 to now. This study aimed to assess the relationship of HO and uric acid. The investigators
 retrospectively reviewed the demographics of participants who undergone the surgery for elbow
 trauma in our hospital between January 2012 and December 2018. One hundred participants
 included in our study. The participants were divided into two groups by the existing HO or
 not. The serum uric acid between both groups were compared by using the independent samples
 student T tests.
The investigators retrospectively analyzed the demographics of these participants in our
 hospital who underwent the surgery after trauma of elbow joint between January 2012 and
 December 2018. All of the participants had a previous history of elbow joint fractures
 including distal humerus fracture or proximal ulna fracture or capitulum radii fracture or
 elbow fracture dislocation. According to X ray or CT scan, the participants were divided into
 two groups. One group the participants had not existed radiographic evidence of heterotopic
 ossification or formatted ectopic lamellar bone. And the other group is the participants with
 radiographic evidence of heterotopic ossification. And we recorded patient serum uric acid,
 sex and age, Body Mass Index (BMI), the situation of joint trauma and comorbid conditions
 including diabetes mellitus or impaired blood glucose, gout, metabolic syndrome, osteoporosis
 and various vitamin deficiency diseases. Moreover, the grades of heterotopic ossification
 were recorded for all patients according to Hastings and Graham Classification System for
 Heterotopic Ossification at the Elbow Joint.
Inclusion Criteria:

 -  Have a previous history of elbow joint fracture or dislocation that conform to its
 manifestations and signs. And it is diagnosed by X-ray test. HO must accord with the
 relative diagnostic criteria5 and have imaging evidences of heterotopic ossification.

 -  Have complete clinical and imaging dates.

 -  The age>18 and no gender limitation.

 -  The patient is being a relatively stable physical and mental state without acute
 injection or diseases.

 Exclusion Criteria:

 -  Have a history of diabetes mellitus or impaired blood glucose, metabolic syndrome and
 gout or renal dysfunction (creatinine ≥ 1.5 mg/dL) that apparently influence glucose,
 lipid and protein metabolic of the body.

 -  Have a history of taking drugs that can influence uric acid metabolic including gout
 suppressant, diuretic, small-dose aspirin (75~300mg/d) or large-dose aspirin (>3g/d),
 anti-tuberculosis drugs, immunosuppressor, nicotinic acid and anti-tumor drugs such as
 cyclophosphamide and so on.