The HPV Self-test as a Test of Cure in Madagascar
The HPV Self-test as a Test of Cure in Madagascar
The purpose of this study is to find out whether Self-HPV may be an accurate method for the
 follow-up of women with a history of HPV infection.
The efficacy and the availability of cold coagulation render it a valuable technique for the
 treatment of precancerous lesions in low-resource settings. The Human Papillomavirus (HPV)
 test performed by women themselves (HPV self-test) could be an efficient method to assess the
 long-term risk of recurrent/persistent disease in women with a history of HPV infection and
 cervical intra-epithelial lesions grade 2 or higher (CIN2+).

 A total of 443 HPV-positive women, aged 30-65 years, have been selected through a screening
 campaign conducted in Ambanja, Madagascar, between 2013 and 2015. Of these, 260 have been
 treated by cold coagulation, conisation or electrocauterization. A follow-up visit at 1-3
 years after primary screening will be organized for all HPV-positive women detected at
 primary screening. Participants will perform an HPV self-test. A sample for cytology and HPV
 testing will also be collected by the physician. The goal of the study will be the
 histological search for CIN2+ lesions at one to three years after primary screening.

 The investigators expect to see that Self-HPV may be an accurate method for the follow-up of
 women with a history of HPV infection.
Inclusion Criteria:

 -  women previously positive at HPV testing

 Exclusion Criteria:

 -  pregnancy