Immun Status at Pancreatitis Patients
Immun Status at Pancreatitis Patients
Pancreatitis is a common complication especially in patients with gallbladder stones, most
 patients with biliary pancreatitis may recover spontaneously without sequelae, but in 10-20%
 of patients, the disease is severe and mortality rates of up to 30% are detected in these
 patients. In the evaluation of acute biliary pancreatitis, many scoring systems have been
 established (Atlanta, Ranson, APACHE, BISAP etc.) from past to present to determine morbidity
 and mortality of the disease.

 In this study, the investigators aimed to evaluate the correlation between morbidity and
 mortality of acute biliary pancreatitis and serum proinflammatory cytokines with ELISA and
 lymphocyte subtypes with Flow-cytometry.
Pancreatitis is a common complication especially in patients with gallbladder stones, most
 patients with biliary pancreatitis may recover spontaneously without sequelae, but in 10-20%
 of patients, the disease is severe and mortality rates of up to 30% are detected in these
 patients. In patients with severe pancreatitis, aggressive fluid replacement, organ damage
 follow-up, appropriate antibiotherapy, and endoscopic sphincterotomy and radiological
 interventions may be of great benefit. In the evaluation of acute biliary pancreatitis, many
 scoring systems have been established (Atlanta, Ranson, APACHE, BISAP etc.) from past to
 present to determine morbidity and mortality of the disease. There are limited number of
 studies in the literature about the immune parameters in the evaluation of acute
 pancreatitis. In a studies, serum inflammatory markers such as IL-1, IL-6 and CD4, CD8 T
 lymphocyte and Treg population were evaluated. It was reported that inflammatory markers,
 especially anti-inflammatory IL-10 levels were elevated in patients with acute pancreatitis,
 and CRP and IL-1β levels of inflammatory markers were higher in patients with organ failure.
 Treg cells are reported to be an independent prognostic factor in determining the severity of
 acute pancreatitis. There is only one study with a limited number of patients in whom PD-1
 values in T lymphocytes and PD-L1 values in monocytes were determined in the literature. In
 this study, it is stated that PD-L1 can be used as a new marker in determining infectious
 complications. In patients diagnosed with acute biliary pancreatitis, determination of the
 course of the disease at the time of diagnosis is extremely important for treatment and
 survival.

 In this study, the investigators aimed to evaluate the correlation between morbidity and
 mortality of acute biliary pancreatitis and serum proinflammatory cytokines with ELISA and
 lymphocyte subtypes with Flow-cytometry.
Inclusion Criteria:

 -  18-80 years old

 -  Diagnosis of acute biliary pancreatitis

 -  Sign the voluntary consent form

 Exclusion Criteria:

 -  Being under 18 or older than 80

 -  Not signing the voluntary consent form

 -  Pancreatitis resulting from an interventional procedure (ERCP, surgery, etc.)

 -  Pregnant women

 -  Being a history of immunodeficiency

 -  Cancer history