PPIs and Gastroesophageal Varices in Liver Cirrhosis (PPIs: Proton Pump Inhibitors)
PPIs and Gastroesophageal Varices in Liver Cirrhosis (PPIs: Proton Pump Inhibitors)
This study is aimed at investigating the effect of PPIs on gastroesophageal varices in liver
 cirrhosis. Half of participants will receive PPI, while the other half will receive a
 placebo.
PPIs can inhibit parietal cell H+/K+-ATPase and reduce secretion of gastric acid. PPIs can
 promote platelet aggregation and stabilize the formation of fibrin thrombosis by maintaining
 the high pH environment in the stomach and inactivating pepsin. The effect of PPIs on
 ulcerative upper gastrointestinal bleeding was confirmed but it is not clear whether PPIs is
 applicable in esophagogastric variceal bleeding whose etiology and bleeding position are
 different from ulcerative upper gastrointestinal bleeding. There is lack of consensus and
 sufficient evidences to support to use PPIs in esophagogastric variceal bleeding in cirrhotic
 patients universally. Nevertheless, the use of PPIs in liver cirrhotic patients with
 gastroesophageal varices is common.
Inclusion Criteria:

 -  Clinical diagnosis of cirrhosis

 -  GEVs was diagnosed by endoscopy

 Exclusion Criteria:

 -  Acute gastrointestinal bleeding need emergency surgery

 -  Acid-related disease, such as peptic ulcer disease or gastroesophageal reflux diseases
 (GERD)

 -  Hepatocellular carcinoma (HCC) or other malignant tumor

 -  History of esophagus, stomach or liver surgery

 -  Child-Pugh C and can't be improved to Child-Pugh A or B

 -  Preparing to be pregnant, pregnant or breast feeding

 -  Allergic to PPIs(proton pump inhibitors) or intolerable

 -  Cannot provide informed consent