Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol Gel in Healthy Volunteers
Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol Gel in Healthy Volunteers
RATIONALE: Lorazepam, diphenhydramine hydrochloride, and haloperidol gel, when absorbed into
 the skin, may be an effective treatment for nausea and vomiting.PURPOSE: This clinical trial
 studies lorazepam, diphenhydramine hydrochloride, and haloperidol gel in healthy volunteers.
OBJECTIVES:I. To study the absorption of the three components in the topical ABH gel in 10
 healthy volunteers, and determine if there are any adverse effects. OUTLINE: Patients apply
 lorazepam, diphenhydramine hydrochloride, and haloperidol gel topically over 2 minutes. After
 completion of study treatment, patients are followed up for 5 hours.
Inclusion Criteria:

 -  Completed a medical screening questionnaire

 -  English speaking

 -  No allergies to the drugs

 -  Able to complete the forms

 -  If a woman of childbearing age, agree to use contraception

 Exclusion Criteria:

 -  History of substance abuse, psychiatric disorder, acquired brain injury, the
 possibility of pregnancy (not using birth control, and of child bearing age)

 -  Use of any medication that would contraindicate benzodiazepine administration

 -  Pregnant or nursing