Chinese PD-LRRK2 Registry
Chinese PD-LRRK2 Registry
The purpose of the Chinese PD-LRRK2 Registry(CPD-LRRK2R) is to develop a database of patients
 of Parkinson's disease with leucine-rich repeat kinase 2 (LRRK2) gene variants in mainland
 China.
Parkinson's disease (PD) is the second most common disorder among neurodegenerative diseases.
 LRRK2 missense mutations are the most common known genetic cause of PD. However, some
 polymorphisms of LRRK2 such as G2385R and R1628P can also affect the risk of developing PD.
 The investigators aim to establish a database of PD with LRRK2 variants and characterize the
 clinical manifestation of these patients in mainland China.

 Method:

 1. Peripheral blood from patients has been tested to have LRRK2 gene variants.

 2. Clinical manifestation will be measured by scales and neurological tests. Standard
 scales include: Unified Parkinson's Disease Rating Scale(UPDRS), Hoehn-Yahr stages,
 Non-Motor Symptoms Scale (NMSS), mini-mental state examination (MMSE), Parkinson disease
 sleep scales (PDSS), Rapid Eye Movement Sleep Behaviour Disorder Questionnaire(RBDQ-HK),
 Epworth Sleepiness Scale (ESS), Rome III functional constipation scale, the Scale for
 Outcomes in PD for Autonomic Symptoms (SCOPA-AUT), Parkinson Fatigue Scale (PFS),
 Cambridge-Hopkins Restless Legs Syndrome questionnaire (CHRLSq), Hyposmia rating
 scale(HRS), Hamilton depression scale, the 39-item Parkinson's Disease
 Questionnaire(PDQ-39), Freezing of gait scale(FOG), dyskinesia related scales,
 Wearing-off scale(WO).

 3. The investigators will also exam the blood biomarkers of PD such as uric acid and
 peripheral inflammatory markers.
Inclusion Criteria:

 -  Patients diagnosed with PD by the United Kingdom Parkinson's Disease Society Brain
 Bank clinical diagnostic criteria or other standard criteria; PD patients detected
 with positive LRRK2 variants

 Exclusion Criteria:

 -