Finding Early Predictors of Myocardial Dysfunction
Finding Early Predictors of Myocardial Dysfunction
The study objective is to clarify the grounds of heart exertional dyspnoea stenocardia in
 patients with well-controlled stage I or II hypertension according to European Society of
 Hypertension, without changes in epicardial coronary arteries in CT coronary angiography and
 normal resting echocardiography result, and to assess of potential early markers of heart
 hypertrophy and failure in patients with hypertension.
The study is to allow for identification of patients with hypertension, in whom an early
 introduction of pharmacological treatment of heart failure HF should be considered.
 Evaluation in the detection of asymptomatic myocardial dysfunction will include potential
 heart failure markers such as: cardiotrophin 1, cystatin C, serum syndecan-4, collagen III
 N-terminal propeptide [PIIINP], NT-proBNP, IL1RL1 and modern echocardiography methods in
 order to increase the effectiveness of prevention, diagnosis and treatment optimalization.

 Material and study plan about 100 persons (age 30-70 years old) will be included in the
 study, patients with stage I or II primary hypertension according to the European Society of
 Hypertension: Group A- 15 patients without symptoms of heart failure Group B- 30 patients
 with exertional dyspnoea Group C - 40 patients with overt heart failure

 In group B (patients with exertional dyspnea/stenocardia) we will include only patients who
 have undergone CT coronary angiography without any identified changes in the epicardial
 coronary arteries, which will facilitate answering the presented purpose of research.
 Patients in groups A and B with normal resting echocardiography and treated with a maximum of
 2 antihypertensive drugs (an ACE inhibitor or a sartan as therapy base), according to the
 following regimen:

 ACEI/ARB + diuretic ACEI/ARB + calcium channel antagonist Group C - treatment in accordance
 with the standards for heart failure. Each patient will be informed about the objectives of
 the study and give written consent to participate.

 After signing informed consent patients will have performed the following tests:

 -  Interview and documentation analysis,

 -  Physical examination,

 -  Electrocardiogram

 -  Echocardiography at rest and during submaximal exercise on a bicycle ergometer

 -  Levels of markers: cystatin C, cardiotrophin-1, Procollagen III N-Terminal Propeptide
 (PIIINP), Syndecan 4 (SDC4) and NT-proBNP, IL1RL1. Each patient will be informed about
 the objectives of the study and give written consent to participate.
Inclusion Criteria:

 -  persons (age 30-70 years old) will be included in the study, patients with stage I or
 II primary hypertension according to the European Society of Hypertension

 Exclusion Criteria:

 -  with coronary artery disease or a history of coronary artery disease (A, B)

 -  with unstable hypertension

 -  with a positive stress test

 -  with NYHA class III-IV heart failure

 -  after percutaneous or surgical revascularization

 -  with diabetes

 -  with GFR < 60

 -  with hyperthyroidism and hypothyroidism

 -  active smokers

 -  with an implanted pacemaker

 -  with obesity level II and III

 -  with ECG-arrhythmia

 -  pregnant and lactating

 -  with congenital heart disease

 -  with hemodynamically significant acquired heart defects

 -  with cardiomyopathies (A,B)

 -  with cancer

 -  with anemia

 -  abusing alcohol or drugs

 -  with chronic inflammatory and other diseases

 -  or who have not given their informed consent to participate in the study