Expanded Treatment Prot of Panobinostat in Combo w/ Bortez and Dex in Pts w/ Relapsed and/or Refractory Multiple Myeloma
Expanded Treatment Prot of Panobinostat in Combo w/ Bortez and Dex in Pts w/ Relapsed and/or Refractory Multiple Myeloma
This will be a multi-center, open label, expanded treatment protocol of panobinostat,
 bortezomib and dexamethasone in patients with relapsed and/or refractory multiple myeloma.
 Panobinostat will be administered at a starting dose of 20mg orally three times a week (every
 other day) for two weeks on and one week off, with dose adjustments permitted based on
 observed toxicity. Bortezomib will be administered either intravenously or sub-cutaneously,
 twice a week on days 1 and 4, two weeks on 1 week off. After 8 cycles of treatment, patients
 who have achieved stable disease or better by modified EBMT 1998 criteria may continue
 combination therapy with bortezomib dosing changed to days 1 and 8 of a 21 day cycle for up
 to 48 weeks of therapy. At the end of the treatment period, (48 weeks) patients with stable
 disease or better may continue on therapy at the discretion of their investigator until
 September 2015 or until drug is commercially available, whichever comes first. Patients who
 have not achieved at least stable disease by 8 cycles must discontinue from study treatment.
 Dexamethasone will be administered on the day of and the day immediately following bortezomib
 treatment. Patients will not receive any study treatment during the third week of each cycle.
 Cycles will be defined as 21 days of treatment. Investigators may not add any other
 anti-myeloma agents (with the exception of bisphosphonates) while patients remain on study
 treatment. Patients will remain on study until disease progression, unacceptable toxicity, or
 end of the study
Inclusion Criteria:

 -  This study is intended for patients with relapsed and/or refractory multiple myeloma,
 who have received at least one prior line of therapy. Patients must require
 retreatment as per IMWG definitions (Kyle et al 2003). Approximately 50-100 patients
 are expected to be enrolled into this trial.

 -  Patient has a previous diagnosis of multiple myeloma, based on IMWG 2003 definitions
 all three of the following criteria had been met:

 -  Monoclonal immunoglobulin (M component) on electrophoresis, and on immunofixation on
 serum or on total 24 hour urine (or demonstration of M protein in cytoplasm of plasma
 cell for non secretory myeloma).

 -  Bone marrow (clonal) plasma cells ≥ 10% or biopsy proven plasmacytoma

 -  Related organ or tissue impairment (CRAB symptoms: anemia, hypercalcemia, lytic bone
 lesions, renal insufficiency, hyperviscosity, amyloidosis or recurrent infections)

 -  Patients who have received allogeneic stem cell transplant and do not have active
 graft vs host disease requiring immunosuppressive therapy are eligible.

 -  Patient with multiple myeloma (per IMWG 2003 definition) that is relapsed and/or
 refractory to at least one prior line of therapy and requires retreatment

 -  Relapsed-and-refractory to a therapy, provided that the patient meets any of the
 following conditions:

 -  Relapsed, defined by disease that recurred in a patient that responded under a prior
 therapy, by reaching a MR or better, and had not progressed under this therapy nor up
 to 60 days of last dose of this therapy. Patients who previously responded to
 treatment with BTZ are eligible.

 -  Patient has relapsed to at least one prior line and patient was refractory to at least
 one prior line by either not reaching a MR, or progressed while under this therapy, or
 within 60 days of its last dose. Patients previously refractory to BTZ are also
 eligible.

 -  Patients with primary refractory disease are eligible.

 -  Patients who have previously received high dose therapy/autologous stem cell
 transplant are eligible

 -  Patients who have received allogeneic stem cell transplant and do not have active
 graft vs host disease requiring immunosuppressive therapy are eligible

 Exclusion Criteria:

 -  Patient has shown intolerance to bortezomib, dexamethasone or panobinostat or has any
 contraindications to any of these therapies. following available prescribing
 information

 -  Allogeneic stem cell transplant recipient presenting with graft versus host disease
 either active or requiring immunosuppression

 -  Patient has grade ≥ 2 peripheral neuropathy or grade 1 peripheral neuropathy with pain
 on clinical examination within 14 days of treatment

 -  Patient taking any anti-cancer therapy concomitantly

 -  Patient has second primary malignancy < 3 years of first dose of study treatment
 (except for treated basal or squamous cell carcinoma, or in situ cancer of the cervix)