Efficacy and Safety of Sugammadex in Renal Diseased Patients
Efficacy and Safety of Sugammadex in Renal Diseased Patients
The purpose of this study is to determine whether sugammadex reverses a profound
 neuromuscular blockade induced by rocuronium in patients with end-stage renal disease just as
 effectively and safely as it does in patients with normal renal function.
Sugammadex antagonizes rocuronium induced neuromuscular blockade by encapsulating the
 molecules of this agent in the plasma and originating a complex which is highly stable, and
 mainly eliminated by the kidneys. In patients with end stage renal disease, this complex
 remains in the circulation for days. Previous studies have shown that sugammadex adequately
 reverses the blockade induced by rocuronium in such patients, and no evidence of recurrence
 was observed after a dosis of 2 mg/Kg administered to reverse a moderate level of blockade.
 To our knowledge, nothing has been published so far on the reversal of profound blockade by
 sugammadex in patients with renal failure.

 The aim of our study was to evaluate the efficacy and safety of sugammadex in the reversal of
 profound neuromuscular block (NMB) induced by rocuronium in patients with end-stage renal
 failure and compare it to patients with normal renal function.
Inclusion Criteria:

 -  age between 18 and 65 years old

 -  end-stage renal disease defined by clearance of creatinine < 30 ml/min

 -  normal renal function defined by clearance if creatinine > 90 ml/min

 -  candidates to elective surgical procedures (control group) or kidney transplantation
 (renal group) under general anaesthesia

 Exclusion Criteria:

 -  pregnant and breastfeeding women

 -  patients with known or suspected neuromuscular disorders

 -  patients with hepatic disfunction

 -  a history of malignant hyperthermia

 -  allergy to narcotics, rocuronium or other medication used during general anaesthesia

 -  patients receiving medication known to interfere with the action of rocuronium (amino
 glycoside antibiotics, anticonvulsants, or magnesium)