Efficacy and Safety of Intranasal Morphine for Pain After Elective Orthopedic Surgery
Efficacy and Safety of Intranasal Morphine for Pain After Elective Orthopedic Surgery
Multiple-center, multiple-dose, randomized, double-blind, six-arm, active- and
 placebo-controlled study in patients with moderate to severe post-surgical pain from elective
 orthopedic surgery with safety observed for a total of 30 hours post first dose.
Multiple-center, multiple-dose, randomized, double-blind, six-arm, active- and
 placebo-controlled study of repeated intermittent PRN dosing for 24 hours of Intranasal (IN)
 Morphine Nasal Spray (MNS075) 7.5 mg and 15 mg, 7.5 mg IV morphine infusions and placebo
 (either IN or IV), in patients with moderate to severe post-surgical pain from elective
 orthopedic surgery with safety observed for a total of 30 hours post first dose.
Inclusion Criteria:

 -  Over 18 years old

 -  Scheduled (within two weeks of the screening visit) to undergo elective orthopedic
 surgery (e.g., bunionectomy, arthroscopic knee surgery, rotator cuff repair)

 -  Moderate to severe pain within 8 hours following completion of the required surgery

 Exclusion Criteria:

 -  Previous anaphylactic or serious allergic reaction to shellfish or opioids

 -  History of sleep apnea

 Other Inclusion/Exclusion Criteria May Apply