Spray vs EMLA Cream on Pain During Intra-articular Injection
Spray vs EMLA Cream on Pain During Intra-articular Injection
All participants are randomly allocated to the spray group, EMLA group and placebo group. In
 spray group, participants receive an application of placebo cream at the needle electrode
 insertion site 60 minutes before needle insertion, and a self adhering dressing is placed
 over the site. After 60 minutes, the dressing and cream are removed from the site, then the
 insertion site is sprayed from a distance of 30 cm for 5 seconds or until the skin was
 blanched, then intra-articular injection of shoulder is performed. Immediately after
 injection, participants are asked to fill out the visual analog scale for injectional pain,
 five point Likert scale for satisfaction about the topical anesthesia. In EMLA group,
 participants receive an EMLA cream and placebo spray. In placebo group, participants receive
 a placebo cream and placebo spray.
All participants are randomly allocated to the spray group, EMLA group and placebo group.

 In spray group, participants receive an application of placebo cream at the needle electrode
 insertion site 60 minutes before needle insertion, and a self adhering dressing is placed
 over the site. After 60 minutes, the dressing and cream are removed from the site, then the
 insertion site is sprayed using ethyl chloride spray (Walter Ritter GmbH and Co., Hamburg,
 Germany) from a distance of 30 cm for 5 seconds or until the skin was blanched, then
 intra-articular injection of shoulder is performed. Immediately after injection, participants
 are asked to fill out the visual analog scale for injectional pain, five point Likert scale
 for satisfaction about the topical anesthesia.

 In EMLA group, participants receive an application of EMLA cream at the needle electrode
 insertion site 60 minutes before needle insertion, and a self adhering dressing is placed
 over the site. After 60 minutes, the dressing and cream are removed from the site, then the
 insertion site is sprayed using placebo spray (Evain Eau Minerale Naturelle, a pure water
 spray with hydrocarbon propellant), then intra-articular injection of shoulder is performed.
 Immediately after injection, participants are asked to fill out the same scales.

 In placebo group, participants receive a placebo cream and placebo spray.
Inclusion Criteria:

 -  Who had a normative schedule of intra-articular injection of shoulder

 Exclusion Criteria:

 -  those who refused to participate, those who were unable to understand a visual analog
 scale or a Likert scale, those with a history of an allergic reaction to vapocoolant
 spray or lidocaine, those with a history of cold intolerance (eg, Raynaud syndrome),
 those who took pain medications or had used topical anesthetics within the previous 24
 hours, those with prior history of intra-articular injection of shoulder, those who
 exhibited an abnormal shoulder sensation on neurologic examination