PROGRESSive Withdrawal Esomeprazole and Acid-related Symptoms
PROGRESSive Withdrawal Esomeprazole and Acid-related Symptoms
Rebound acid hypersecretion (RAHS), defined as an increase in gastric acid secretion above
 pre-treatment levels after PPIs therapy is observed within two weeks after withdrawal of
 treatment and could theoretically lead to acid-related symptoms such as heartburn, acid
 regurgitation, or dyspepsia that might result in resumption of therapy. A plausible
 physiologic theory for the rebound phenomenon suggests that long-term, elevated gastric pH
 caused by blockage of the proton-pumps stimulates compensatory gastrin release.
 Interestingly, Reimer et al. demonstrated the occurrence of RAHS in healthy volunteers who
 had received eight weeks of esomperazole. The clinical symptoms occured in a different
 prevalence compared with placebo treated patients at ten weeks after withdrawal and until the
 end of the study (twelve weeks). Twenty to twenty-two percent of patients displayed symptoms
 ten or twelve weeks after having discontinued PPIs while they occured in 1.7-7% of
 placebo-treated patients. Efforts should be pursued to restrict PPI therapy use to patients
 likely to benefit from it.

 In this context, we propose to investigate the benefit of a progressive decrease in doses of
 esomeprazole compared to a sudden discontinuation. This is a randomized, double-blind,
 placebo-controlled trial with 156 patients treated by esomeprazole 40mg since four weeks
 least, randomized to one week of placebo or one week of esomeprazole 20mg. We want to compare
 the prevalence of clinical gastrointestinal symptoms between patients with progressive
 discontinuation (one week of esomeprazole, 20mg, then discontinuation) or those with sudden
 discontinuation of esomeprazole 40mg.
Inclusion Criteria:

 -  Treatment by esomeprazole 40mg since 4 weeks or more

 -  Esomeprazole withdrawal decided by the clinician

 -  Male and female aged 18-90 years

 -  Volunteers to participate to the study

 -  Must understand and read French language

 -  Must be able to give a written informed consent

 Exclusion Criteria:

 -  Impairment of cognitive status

 -  Current indication to continue PPI treatment

 -  History of erosive and ulcerative esophagitis, Barrett esophagus, Zollinger-Ellison
 syndrome

 -  Short-term treatment of documented ulcer disease, as part of a combination regimen for
 Helicobacter pylori (HP) eradication

 -  Prevention of ulcers due to non-steroidal anti-inflammatory drugs.

 -  Hepatic impairment (TP<60%)

 -  Hypersensitivity to omeprazole (CYP2C19 activity) or esomeprazole

 -  Current pregnancy or current breastfeeding