Study of Factors Associated With the Volumetric and Areal Bone Mineral Density and Bone Strength in Parkinson's Disease
Study of Factors Associated With the Volumetric and Areal Bone Mineral Density and Bone Strength in Parkinson's Disease
Studies show that patients with idiopathic Parkinson's disease (IPD) have an increased risk
 of fracture, particularly hip fracture whose complications and postoperative mortality appear
 to be higher than in the general population.

 This increased risk of fracture is due partly to an increased risk of falling, and secondly
 to an impairment of bone tissue with lower bone mineral density (BMD). A meta-analysis
 concluded that patients with IPD have lower BMD than healthy controls. Prospective studies
 also showed rapid bone loss in these patients compared with controls. The association between
 low BMD and IPD seems dependent on the severity and duration of the disease even if some data
 are contradictory. Various mechanisms may explain this bone loss including weight loss,
 malnutrition and a low level of physical activity. However, enrollments in these studies are
 often weak and it is difficult to conclude on the real impact of these factors on bone loss
 in the IPD. The main objective of our study is to assess and prioritize from these various
 bone loss mechanisms. Bone assessment by "peripheral quantitative computed tomography" (pQCT)
 will also assess the impact of various risk factors on bone strength parameters. The
 prevalence of vertebral compression fractures in the IPD, at this day unknown can be
 evaluated. This study will also estimate the prevalence of vertebral compression fractures in
 the IPD.
Studies show that patients with idiopathic Parkinson's disease (IPD) have an increased risk
 of fracture, particularly hip fracture whose complications and postoperative mortality appear
 to be higher than in the general population.

 This increased risk of fracture is due partly to an increased risk of falling, and secondly
 to an impairment of bone tissue with lower bone mineral density (BMD). A meta-analysis
 concluded that patients with IPD have lower BMD than healthy controls. Prospective studies
 also showed rapid bone loss in these patients compared with controls. The association between
 low BMD and IPD seems dependent on the severity and duration of the disease even if some data
 are contradictory. Various mechanisms may explain this bone loss including weight loss,
 malnutrition and a low level of physical activity. However, enrollments in these studies are
 often weak and it is difficult to conclude on the real impact of these factors on bone loss
 in the IPD. The main objective of our study is to assess and prioritize from these various
 bone loss mechanisms. Bone assessment by "peripheral quantitative computed tomography" (pQCT)
 will also assess the impact of various risk factors on bone strength parameters. The
 prevalence of vertebral compression fractures in the IPD, at this day unknown can be
 evaluated. This study will also estimate the prevalence of vertebral compression fractures in
 the IPD.
Inclusion Criteria:

 -  Idiopathic parkinson's disease (UKPDSBB criteria)

 -  Hoen and Yahr score < 4 (ON periods)

 -  Age between 35 and 70 years old

 -  Independent person at home

 Exclusion Criteria:

 -  Dementia patient and progressive mental illness

 -  Patient with severe tremor

 -  Incapacity to walk over ten minutes

 -  Treatment influencing bone metabolism

 -  Disease influencing phosphocalcic metabolism

 -  Severe comorbidities

 -  Pregnant woman