Goal-directed Fluid Resuscitation in Acute Pancreatitis
Goal-directed Fluid Resuscitation in Acute Pancreatitis
Vigorous fluid resuscitation is currently believed to play a key role in reducing
 complications associated with acute pancreatitis. However, aggressive fluid replacement can
 be associated with complications such as pulmonary fluid sequestration. The purpose of this
 study is to evaluate alternative approaches to early fluid resuscitation for patients with
 acute pancreatitis.
Primary Aim: Evaluate the impact of a goal-directed fluid resuscitation protocol compared to
 standard fluid resuscitation on systemic inflammation in patients with acute pancreatitis.

 Secondary Aim: Evaluate the impact of resuscitation with Lactated Ringer's compared to normal
 saline on systemic inflammation in acute pancreatitis.
Inclusion Criteria:

 -  acute pancreatitis diagnosed by at least 2 criteria

 -  adult patients at least 18 years of age

 Exclusion Criteria:

 -  history of severe cardiovascular, respiratory, renal, hepatic or
 hematologic/immunologic disease

 -  concurrent metabolic or physiologic derangement requiring specific fluid management

 -  pregnancy

 -  patients transferred from acute care hospital