Evaluation of LB in THA
Evaluation of LB in THA
This study aims to compare the effectiveness of liposomal bupivacaine (LB) versus standard of
 practice local injection containing plain bupivacaine.
Investigation of liposomal bupivacaine to determine if this drug is a valid alternative to
 standard of care local anesthesia based on evaluation in total hip arthroplasty This is a
 retrospective cohort study of consecutive patients undergoing THA at 3 hospitals within a
 U.S. healthcare system from January 2013 to July 2016. The control group received the
 standard of care undergoing THA (plain bupivacaine or ropivacaine), while the LB group
 received a mixture containing this drug as the alternative to the standard care. The outcome
 variables include hospital length of stay, readmissions, total hospital costs, patient pain
 scores, discharge disposition, morphine equivalent opioid consumption, and postoperative
 patient ambulation. Generalized linear models were employed to examine aforementioned
 outcomes controlling for age, gender, race, BMI, alcohol use, tobacco use, and surgeons..
Inclusion Criteria:

 -  Males or females over the age of 18

 -  have undergone a THA surgery during the period of interest January 2013 to July 2016).

 Exclusion Criteria:

 -  excluded from the study based on the following criteria:

 1. Concurrent, painful, physical condition or concurrent surgery that may require
 analgesic treatment in the postoperative period for pain that is not strictly
 related to the surgical treatment;

 2. Uncontrolled anxiety, schizophrenia, or other psychiatric disorder; and

 3. Significant renal or hepatic insufficiency.