Penehyclidine and Postoperative Nausea and Vomiting After Bimaxillary Surgery
Penehyclidine and Postoperative Nausea and Vomiting After Bimaxillary Surgery
Postoperative nausea and vomiting (PONV) are common complications after surgery. Patients
 undergoing orthognathic surgery are reported to have a high rate of PONV, especially those
 undergoing bimaxillary surgery. Activation of cholinergic system plays an important role in
 the development of PONV. Penehyclidine is an muscarinic antagonists which selectively block
 M1 and M3 receptors and is commonly used to decrease oral secretion. The purpose of this
 retrospective cohort study is to investigate whether use of penehyclidine is associated with
 a reduced risk of PONV in patients undergoing bimaxillary surgery.
Postoperative nausea and vomiting (PONV) are one of the most frequent complications after
 surgery, and are associated with patients' dissatisfaction after anesthesia and surgery.
 Orthognathic surgery is widely performed for the correction of dentofacial deformities. PONV
 is common after orthognathic surgery. Despite of improved anti-emetic prophylaxis, patients
 undergoing orthognathic surgery are reported to have a high incidence of PONV, especially
 those after bimaxillary surgery.

 It is known that activation of central cholinergic system plays an important role in the
 development of PONV. Muscarinic antagonists such as scopolamine can block muscarinic
 receptors in the cerebral cortex and produce anti-emetic effects. Penehyclidine is a new
 muscarinic antagonists which selectively block M1 and M3 receptors. It has fewer adverse
 effects compared with other anticholinergics. The purpose of this retrospective cohort study
 is to investigate whether use of penehyclidine is associated with a reduce risk of PONV in
 patients undergoing bimaxillary surgery.
Inclusion Criteria:

 -  Age ≥16 years;

 -  Underwent elective bimaxillary surgery under general anesthesia.

 Exclusion Criteria:

 -  Age <16 years;

 -  Missing data.