Exercise Capacity Under Various FiO2 and Oxygen Flow Rates Using HFNC
Exercise Capacity Under Various FiO2 and Oxygen Flow Rates Using HFNC
The purpose of this study is to compare the exercise capacity (6-min walking distance) under
 the following 4 conditions using High-flow nasal cannula (HFNC); 1. FIO2 value that the
 minimum SpO2 value in a 6-minute walking test (6MWT) is 86-88%, and a flow of 10 L/min 2.
 FIO2 value that the minimum SpO2 value in a 6MWT is 86-88%, and a flow of 40-50 L/min 3. FIO2
 value that the minimum SpO2 value in a 6MWT is 92-94%, and a flow of 10 L/min 4. FIO2 value
 that the minimum SpO2 value in a 6MWT is 92-94%, and a flow of 40-50 L/min
In the pervious study, the investigators demonstrated that 4 weeks of training using both
 high FIO2 and high flow through an HFNC significantly improved the 6MWD compared with
 training using a 6 L/min nasal cannula. However, it was unclear whether the effects of
 pulmonary rehabilitation under HFNC were due to high FIO2, high flow rate, or a synergistic
 effect. It is also unknown whether there are differences in the effects of pulmonary
 rehabilitation under HFNC for each underlying disease.
Inclusion Criteria:

 -  Subjects with a minimum SPO2 of 88% or less during performing 6MWT under HFNC (FIO2
 0.21 and a flow rate of 10L/min)

 -  Subjects who have been clinically stable for the last 2 weeks

 -  Subjects with written informed consent to participate in this study

 Exclusion Criteria:

 -  Subjects with severe cardiovascular disease, liver disease, neurological disease, and
 renal failure

 -  Subjects who needed antimicrobial agent or steroid administration for pneumonia and
 exacerbation of respiratory disease in the last 2 weeks

 -  Subjects who cannot undergo 6MWT due to severe heart failure, arteriosclerosis
 obliterans or spinal disease