A Study of JNJ-64417184, Administered as an Oral Solution, in Healthy Participants
A Study of JNJ-64417184, Administered as an Oral Solution, in Healthy Participants
The purpose of this study is to assess the food effect on the single-dose pharmacokinetic
 (PK) of the JNJ-64417184 oral solution, administered as 2 different formulations, in healthy
 adult participants.
Inclusion Criteria:

 -  Must have a body mass index (BMI; weight [kg]/height^2 [m^2]) between 18.0 and 30.0
 kilogram per meter square (kg/m^2), extremes included, and a body weight not less than
 50.0 kg at screening

 -  Healthy on the basis of physical examination, medical and surgical history, and vital
 signs performed at screening. If there are abnormalities, the participant may be
 included only if the investigator judges the abnormalities to be not clinically
 significant or to be appropriate and reasonable for the population under study

 -  Healthy on the basis of clinical laboratory tests performed at screening

 -  Must have a normal 12-lead electrocardiogram (ECG) (triplicate) at screening

 -  Female participant must have a negative highly sensitive serum beta-human chorionic
 gonadotropin (beta- hCG) pregnancy test at screening and a negative urine pregnancy
 test on Day -1

 Exclusion Criteria:

 -  History of liver or renal dysfunction significant cardiac, vascular, pulmonary,
 gastrointestinal (such as significant diarrhea, gastric stasis, or constipation that
 in the investigator's opinion could influence drug absorption or bioavailability),
 endocrine, neurologic, hematologic, rheumatologic, psychiatric, neoplastic, or
 metabolic disturbances

 -  Past history of cardiac arrhythmias (example, extrasystoli, tachycardia at rest),
 history of risk factors for Torsade de Pointes syndrome (example, hypokalemia, family
 history of long QT Syndrome)

 -  Any evidence of heart block or bundle branch block at screening

 -  Current human immunodeficiency virus type-1 (HIV-1) or HIV-2 infection (confirmed by
 antibodies) at screening

 -  A history of clinically significant drug allergy such as, but not limited to,
 sulfonamides and penicillins, or drug allergy witnessed in previous studies with
 experimental drugs