Study of Peripheral Blood Non-coding RNAs as Diagnosis and Prognosis Biomarker for Acute Pancreatitis
Study of Peripheral Blood Non-coding RNAs as Diagnosis and Prognosis Biomarker for Acute Pancreatitis
It is important to identify patients with acute pancreatitis who are at risk for developing
 persistent organ failure early in the course of disease. The investigators evaluated whether
 peripheral blood non-coding RNAs, including microRNAs and long noncoding RNA (lncRNA), could
 serve as a good marker for detection of acute pancreatitis with persistent organ failure at
 early phase.
Acute pancreatitis is a sudden inflammation of the pancreas. It can have severe complications
 and high mortality despite treatment. While mild cases are often successfully treated with
 conservative measures, such as fasting and aggressive intravenous fluid rehydration, severe
 cases may require admission to the intensive care unit or even surgery to deal with
 complications of the disease process. The diagnosis of severe acute pancreatitis at an early
 phase remain a major challenge for clinicians.

 Therefore, many biologic markers have been studied in an effort to improve the diagnostic
 rate and determine the severity of acute pancreatitis but with disappointing results.
 Non-coding RNAs, including microRNAs and long noncoding RNA (lncRNA), have recently been
 validated to stably exist in peripheral blood. Several publications showed that it may serve
 as potential markers for various diseases, including cancer and inflammation. Our current
 study evaluated whether and which kind of non-coding RNAs could serve as good markers for
 severe acute pancreatitis.
Inclusion Criteria:

 -  Patients who was diagnosed acute pancreatitis

 -  Male or female

 -  18 Years and older

 -  written informed consent

 Exclusion Criteria:

 -  Symptoms of acute pancreatitis present for more than 72 hours

 -  Age under 18 years

 -  Pregnancy

 -  patients unable to consent