Hepatic Arterial Infusion of Oxaliplatin, Fluorouracil/Leucovorin Versus Sorafenib in Advanced Hepatocellular Carcinoma
Hepatic Arterial Infusion of Oxaliplatin, Fluorouracil/Leucovorin Versus Sorafenib in Advanced Hepatocellular Carcinoma
This trial was designed to investigate whether the survival outcome, response rate and safety
 of hepatic arterial infusion of oxaliplatin, fluorouracil/leucovorin regimens for patients
 with Barcelona-Clinic Liver Cancer (BCLC)-C stage hepatocellular carcinoma was superior than
 those of the standard treatment with sorafenib or not.
Hepatocellular carcinoma is the fifth most common malignancy worldwide. Advanced-stage
 disease is found in 25%-70% of HCC at diagnosis, with a median survival time of only 4.2-7.9
 months due to limited treatment options. To date, sorafenib is the only standard treatment
 shown to extend overall survival for advanced hepatocellular carcinoma (Ad-HCC). However, low
 response rates, modest survival advantages and high-level heterogeneity of individual
 response, such limitations of sorafenib prohibit its widespread use in Ad-HCC and more
 alternative therapies are highly required at present.

 Hepatic arterial infusion chemotherapy (HAIC) can provide chemotherapeutic agents to liver at
 higher concentration with lower toxicity and has been reported favorable results in advanced
 HCC. However, HAIC provides good but variable outcomes, with a response rate of 7-81% and
 median survival time of 6-15.9 months. The unstable response may attribute to complicate
 combinations based on various drugs, including fluorouracil (5-FU), cisplatin, doxorubicin,
 mitomycin, leucovorin and interferon. FOLFOX (oxaliplatin, 5-FU/leucovorin) was a regimen
 first used in colon cancer with liver metastasis and reported to be effective both by
 systemic and HAIC in amounts of clinical trials. A recent phase II study has shown that HAI
 of FOLFOX (HAIF) was well tolerated and effective in Ad-HCC. To the investigator's knowledge,
 no clinical studies have been developed on comparing the survival benefit of HAIF with
 sorafenib for patients with Ad-HCC. In this phase III trial, the investigators aimed to
 compare survival outcome, response rate and safety of HAIF with sorafenib in patients with
 Ad-HCC.
Inclusion Criteria:

 -  Written informed consent must be obtained prior to any screening procedures.

 -  Cytohistological confirmation is required for diagnosis of HCC.

 -  Patients with advanced (unresectable and/or metastatic, stage C based on
 Barcelona-Clinic Liver Cancer [BCLC] staging classification) hepatocellular carcinoma
 which would not be suitable for treatment with loco-regional therapies or have
 progressed following locoregional therapy such as surgical resection, percutaneous
 hepatic arterial embolization, radiofrequency ablation, and percutaneous
 interventional therapy.

 -  At least one tumor lesion meeting measurable disease criteria as determined by RECIST
 v1.1. Lesions previously treated with local therapy, such as radiation therapy,
 hepatic arterial embolization, radiofrequency ablation, and percutaneous
 interventional therapy should not be selected unless progression is noted at baseline,
 in which case, these lesions would be considered as non-target lesions.

 -  Current cirrhotic status of Child-Pugh class A-B, with no encephalopathy. Ascites
 controlled by diuretics is permitted in this study.

 -  Availability of a representative tumor tissue specimen (archival tumor tissue is
 allowed) at pre-screening.

 -  Eastern Cooperative Oncology Group Scale for Assessment of Patient Performance Status
 ≤ 2.

 -  Both men and women enrolled in this trial must use adequate barrier birth control
 measures during the course of the trial and 4 weeks after the completion of trial.

 -  Adequate bone marrow, liver and renal function as assessed by central lab by means of
 the following laboratory requirements from samples within 7 days prior to procedure:

 -  Hemoglobin > 100g/L

 -  Absolute neutrophil count >3.0 ×109/L

 -  Neutrophil count > 1.5 ×109/L

 -  Platelet count ≥ 50.0 ×109/L

 -  Total bilirubin < 51 μmol/L

 -  Alanine transaminase (ALT) and aminotransferase (AST) < 5 x upper limit of normal

 -  Albumin > 28 g/L

 -  Prothrombin time (PT)-international normalized ratio (INR) < 2.3, or PT < 6
 seconds above control

 -  Serum creatinine < 110 μmol/L

 -  Willing and able to comply with scheduled visits, treatment plan and laboratory tests.

 Exclusion Criteria:

 -  Received any prior systemic chemotherapy or molecular-targeted therapy for HCC such as
 sorafenib.

 -  Previous local therapy completed less than 4 weeks prior to the dosing and, if present
 any related acute toxicity > grade 1.

 -  Any contraindications for hepatic arterial infusion procedure:

 -  Impaired clotting test (platelet count < 60000/mm3, prothrombin activity < 50%).

 -  Renal failure / insufficiency requiring hemo-or peritoneal dialysis.

 -  Known severe atheromatosis.

 -  Known uncontrolled blood hypertension (> 160/100 mm/Hg).

 -  Patients with any other malignancies within the last 3 years before study start.

 -  History of HCC tumor rupture.

 -  Patients with severe encephalopathy.

 -  Patients with known active bleeding (e.g. from GI ulcers, esophageal varices) within 2
 months prior to baseline/screening visit or with history or evidence of inherited
 bleeding diathesis or coagulopathy.

 -  Clinically significant (CTC grade 3 or 4) venous or arterial thrombotic disease within
 past 6 months.

 -  History of cardiac disease:

 -  Congestive heart failure >New York Heart Association (NYHA) class 2 (refer to
 Appendix 13.9).

 -  Active coronary artery disease (CAD) (myocardial infarction more than 6 months
 prior to study entry is allowed).

 -  Cardiac arrhythmias (>Grade 2 NCI-CTCAE Version 4.0) which are poorly controlled
 with anti-arrhythmic therapy or requiring pace maker.

 -  Uncontrolled blood hypertension (> 160/100 mm/Hg).

 -  Serious, non-healing wound, ulcer, or bone fracture.

 -  History of abdominal fistula, GI perforation, or intra-abdominal abscess within past 6
 months prior to study treatment.

 -  Clinically significant third space fluid accumulation (i.e., ascites requiring tapping
 despite use of diuretic or pleural effusion that either required tapping or is
 associated with shortness of breath).

 -  Patients who have undergone major surgical procedure, open biopsy, or significant
 traumatic injury within 4 weeks of the start of protocol treatment.

 -  History of a bone marrow or solid organ transplant.

 -  Use of biologic response modifiers, such as G-colony stimulating factor (CSF), within
 3 weeks prior to start of study drug. (G-CSF and other hematopoietic growth factors
 may be used in the management of acute toxicity such as febrile neutropenia when
 clinically indicated or at the discretion of the investigator; however, they may not
 be substituted for a required dose reduction). Subjects taking chronic erythropoietin
 are permitted provided no dose adjustment is undertaken within 1 month prior to the
 study or during the study.

 -  Any other condition that would, in the Investigator's judgment, contraindicate
 patient's participation in the clinical study due to safety concerns or compliance
 with clinical study procedures, e.g., infection/inflammation, intestinal obstruction,
 unable or unwilling to swallow medication, social/ psychological issues, etc.

 -  Unable to undergo either contrast-enhanced magnetic resonance imaging (MRI) or
 contrast-enhanced computed tomography (CT).

 -  Known history of human immunodeficiency virus (HIV) seropositivity. HIV testing is not
 required as part of this study.

 -  Patients who have received any other investigational agents within a period of time
 that is less than the cycle length used for that treatment or equal to 4 weeks
 (whichever is shorter) prior to starting study drug and recovered from any side
 effects to grade 1 or less.

 -  Pregnant or nursing (lactating) women, where pregnancy is defined as the state of a
 female after conception and until the termination of gestation, confirmed by a
 positive human chorionic gonadotropin (hCG) laboratory test.

 -  Women of child-bearing potential, defined as all women physiologically capable of
 becoming pregnant, unless they are using highly effective methods of contraception
 during dosing and for 7 days after permanently discontinuing HAIF and/or sorafenib
 treatment. Highly effective contraception methods include:

 -  Total abstinence (when this is in line with the preferred and usual lifestyle of
 the patient. Periodic abstinence (e.g., calendar, ovulation, symptothermal,
 post-ovulation methods) and withdrawal are not acceptable methods of
 contraception.

 -  Female sterilization (have had surgical bilateral oophorectomy with or without
 hysterectomy) or tubal ligation at least six weeks before taking study treatment.
 In case of oophorectomy alone, only when the reproductive status of the woman has
 been confirmed by follow up hormone level assessment.

 -  Male sterilization (at least 6 months prior to screening). For female patients on
 the study the vasectomized male partner should be the sole partner for that
 patient.

 -  Combination of any two of the following (a+b or a+c, or b+c):

 1. Use of oral, injected or implanted hormonal methods of contraception or
 other forms of hormonal contraception that have comparable efficacy (failure
 rate <1%), for example hormone vaginal ring or transdermal hormone
 contraception.

 2. Placement of an intrauterine device or intrauterine system

 3. Barrier methods of contraception: Condom or Occlusive cap (diaphragm or
 cervical/vault caps) with spermicidal foam/gel/film/cream/vaginal
 suppository.

 In case of use of oral contraception women should have been stable on the same pill for a
 minimum of 3 months before taking study treatment.

 Women are considered post-menopausal and not of child bearing potential if they have had 12
 months of natural (spontaneous) amenorrhea with an appropriate clinical profile (e.g. age
 appropriate, history of vasomotor symptoms) or have had surgical bilateral oophorectomy
 (with or without hysterectomy) or tubal ligation at least six weeks ago. In the case of
 oophorectomy alone, only when the reproductive status of the woman has been confirmed by
 follow up hormone level assessment is she considered not of child bearing potential.

 -  Sexually active males unless they use a condom during intercourse while receiving
 treatment and for 7 days after stopping study treatment and should not father a child
 in this period. A condom is required to be used also by vasectomized men in order to
 prevent delivery of the drug via seminal fluid.

 -  Subjects unable to suffer the discomfort of the HAI procedure (e.g. pain,
 claustrophobia, noise).

 -  Any contraindication for sorafenib, oxaliplatin, leucovorin, or fluorouracil
 administration.

 -  Any agents which could affect the absorption or pharmacokinetics of the study drugs.

 -  Known or suspected allergy to the investigational agents or any agent given in
 association with this study.