Early Antenatal Support for Iron Deficiency Anemia
Early Antenatal Support for Iron Deficiency Anemia
This is a randomized, controlled multi-site trial of iron therapy in pregnancy. The purpose
 of this research is to see if second trimester initiation of intravenous (IV) iron therapy is
 better than oral iron therapy for treatment of anemia in pregnancy by improving blood count,
 quality of life and reducing side effects.
Pregnant singletons diagnosed with iron deficiency anemia will be enrolled between 14-24
 weeks and will be randomized 1:1 to either a course of ferumoxytol (510mg x 2 doses 3-8 days
 apart) or oral iron (325mg) twice daily.
Inclusion Criteria:

 -  Singleton gestation

 -  Gestational age <24 weeks

 -  Baseline Hb ≥9.0 and <11.0 with evidence of iron deficiency anemia

 Iron deficiency anemia diagnosed (at any point in patient history) by:

 -  Hb<11.0

 -  Ferritin<30 and/or total iron saturation <20

 Exclusion Criteria:

 -  Sickle cell Disease (NOT sickle cell trait)

 -  Evidence of acute anemia requiring transfusion or IV iron therapy

 -  Major congenital or chromosomal anomaly

 -  Previous use of IV iron in this pregnancy

 -  Severe cardiac, renal, or liver disease

 -  Autoimmune disease (ie Systemic Lupus Erythematosus (SLE)

 -  Allergy or contraindication to either study drug

 -  History of medication allergy, reaction to IV infusion, or reaction to Feraheme or
 other IV iron products