Partial Breast Proton Therapy for Early Stage Breast Cancer
Partial Breast Proton Therapy for Early Stage Breast Cancer
The purpose of this is to determine the efficacy and toxicity of proton therapy when used to
 deliver partial breast radiotherapy in patients with early stage breast cancer with low or
 intermediate risk factors.
Radiation therapy delivered to the whole breast is standard treatment following tumor removal
 for patients with early stage breast cancer. In selected patients, delivering the radiation
 treatment to only the part of the breast involved by the tumor may be a viable alternative.
 This can decrease the amount of normal tissues exposed to irradiation, potentially decrease
 side-effects and shorten the treatment time. Proton beam can decrease the volume of normal
 tissues treated compared to standard forms of radiotherapy. This study will recruit patients
 with early stage breast cancer following surgical removal to undergo partial breast
 radiotherapy with proton beam and determine the recurrence rates and side-effects of
 treatment.
Inclusion Criteria:

 -  Breast carcinoma

 -  DCIS

 -  Age 40 years or higher

 -  Primary tumor 3 cm or less

 -  Lumpectomy with clip placement

 -  Axillary node sampling

 -  Negative margins

 Exclusion Criteria:

 -  Distant metastasis

 -  Multicentric disease

 -  Prior radiation or chemotherapy

 -  Active collagen vascular disease

 -  Pregnant or lactating

 -  BRCA mutation

 -  Lymph nodes with more than microscopic tumor involvement