BAY 43-9006 (Sorafenib) and Bevacizumab (Avastin) To Treat Solid Tumors
BAY 43-9006 (Sorafenib) and Bevacizumab (Avastin) To Treat Solid Tumors
Background:

 -  BAY 43-9006 is an inhibitor of wild-type and mutant B-Raf and c-Raf kinase isoforms in
 vitro, but it also inhibits p38, c-kit, VEGFR-2 and PDGFR-Beta affecting tumor growth as
 well as possibly promoting apoptosis by events downstream of c-Raf.

 -  Bevacizumab is a humanized IgG1 monoclonal antibody (MAb) that binds all biologically
 active isoforms of human vascular endothelial growth factor (VEGF, or VEGF-A) with high
 affinity (k(d)= 1.1nM)

 -  The most common adverse events associated with bevacizumab of any severity include
 asthenia, pain, headache, hypertension, diarrhea, stomatitis, constipation, epistaxis,
 dyspnea, dermatitis and proteinuria.

 -  This Phase I trial is open to patients with all solid tumors.

 Objectives:

 -  Determine the safety and toxicity of the combination of BAY 43-9006 (Sorafenib) and
 bevacizumab.

 -  Determine estimates of biochemical changes in the Ras-Raf-MAPK and VEGF signal
 transduction pathways in tumor and stromal cells in response to treatment at the MTD, at
 least in a pilot fashion, if those changes are statistically significant.

 Eligibility:

 -  Adults with histologically documented solid tumor malignancy that is metastatic or
 unresectable and for which standard curative therapies do not exist or are no longer
 effective.

 -  Patients must be off prior chemotherapy, radiation therapy, hormonal therapy, or
 biological therapy for at least 4 weeks.

 -  All patients enrolling in cohort 2 must have at least one lesion amenable to biopsy.

 -  ECOG performance status 0 or 1 and adequate organ and marrow function.

 Design:

 -  Cohort I will receive BAY 43-9006 and bevacizumab together at the start of study in a
 dose escalation fashion.

 -  Cohort II will be randomized as to which agent they receive for cycle one. Cycles 2 and
 beyond are treated using both agents.

 -  Tumor biopsies will be obtained from patients in Cohort II before treatment, two weeks
 into mono-therapy, and two weeks into combinatorial therapy.

 -  DCE-MRI studies will be obtained on patients in Cohort II before treatment, two weeks
 into monotherapy, four weeks into monotherapy, and two weeks into combinatorial therapy.

 -  FDG-PET studies will be obtained on patients in Cohort II before treatment, two weeks
 into mono-therapy, and two weeks into combinatorial therapy.

 -  Patients will be evaluated for toxicity in clinic every 2 weeks for Cycles 1 and 2, and
 then every 4 weeks.

 -  Patients will be evaluated for response every 8 weeks using the RECIST criteria.

 -  Approximately 62 patients will be needed to achieve the objectives of the trial.
Background:

 -  BAY 43-9006 is an inhibitor of wild-type and mutant B-Raf and c-Raf kinase isoforms in
 vitro, but it also inhibits p38, c-kit, VEGFR-2 and PDGFR-Beta affecting tumor growth as
 well as possibly promoting apoptosis by events downstream of c-Raf.

 -  Bevacizumab is a humanized IgG1 monoclonal antibody (MAb) that binds all biologically
 active isoforms of human vascular endothelial growth factor (VEGF, or VEGF-A) with high
 affinity (k(d)= 1.1nM)

 -  The most common adverse events associated with bevacizumab of any severity include
 asthenia, pain, headache, hypertension, diarrhea, stomatitis, constipation, epistaxis,
 dyspnea, dermatitis and proteinuria.

 -  This Phase I trial is open to patients with all solid tumors.

 Objectives:

 -  Determine the safety and toxicity of the combination of BAY 43-9006 (Sorafenib) and
 bevacizumab.

 -  Determine estimates of biochemical changes in the Ras-Raf-MAPK and VEGF signal
 transduction pathways in tumor and stromal cells in response to treatment at the MTD, at
 least in a pilot fashion, if those changes are statistically significant.

 Eligibility:

 -  Adults with histologically documented solid tumor malignancy that is metastatic or
 unresectable and for which standard curative therapies do not exist or are no longer
 effective.

 -  Patients must be off prior chemotherapy, radiation therapy, hormonal therapy, or
 biological therapy for at least 4 weeks.

 -  All patients enrolling in cohort 2 must have at least one lesion amenable to biopsy.

 -  ECOG performance status 0 or 1 and adequate organ and marrow function.

 Design:

 -  Cohort I will receive BAY 43-9006 and bevacizumab together at the start of study in a
 dose escalation fashion.

 -  Cohort II will be randomized as to which agent they receive for cycle one. Cycles 2 and
 beyond are treated using both agents.

 -  Tumor biopsies will be obtained from patients in Cohort II before treatment, two weeks
 into mono-therapy, and two weeks into combinatorial therapy.

 -  DCE-MRI studies will be obtained on patients in Cohort II before treatment, two weeks
 into monotherapy, four weeks into monotherapy, and two weeks into combinatorial therapy.

 -  FDG-PET studies will be obtained on patients in Cohort II before treatment, two weeks
 into mono-therapy, and two weeks into combinatorial therapy.

 -  Patients will be evaluated for toxicity in clinic every 2 weeks for Cycles 1 and 2, and
 then every 4 weeks.

 -  Patients will be evaluated for response every 8 weeks using the RECIST criteria.

 -  Approximately 62 patients will be needed to achieve the objectives of the trial.
-  INCLUSION CRITERIA:

 Patients must have a solid tumor malignancy that is metastatic or unresectable and for
 which standard curative therapies do not exist or are no longer effective.

 Patients must have histological documentation of cancer confirmed in the Laboratory of
 Pathology/NCI.

 Patients must be off prior chemotherapy, radiation therapy, hormonal therapy, or biological
 therapy for at least 4 weeks. Patients who were receiving mitomycin C, nitrosoureas, or
 carboplatin must be 6 weeks from the last administration of chemotherapy. Patients with
 prostate cancer must continue to receive LHRH agonist (unless orchiectomy has been
 performed). Patients should not be receiving complementary/alternative therapy while on
 study. Furthermore, complementary therapy should be stopped at least 7 days prior to
 enrollment. Any patient who has undergone therapy with a monoclonal antibody must be at
 least 8 weeks from the last treatment.

 All patients enrolling in cohort 2 must have at least one lesion amenable to biopsy. This
 determination will be made by a member of the interventional radiology team or surgical
 associate investigator and an associate investigator. This requirement is not necessary for
 patients in cohort 1.

 Age greater than 18 years.

 ECOG performance status 0 or 1.

 Life expectancy of greater than 3 months.

 Patients must have adequate organ and marrow function as defined below:

 -  Leukocytes greater than 3,000/microliter

 -  Absolute neutrophil count greater than 1,200/microliter

 Platelets greater than 100,000/microliter

 -  Total Bilirubin less than or equal to 1.5 times the institutional upper limits of
 normal

 -  AST(SGOT) and ALT(SGPT) less than or equal to 2.5 times the institutional upper limit
 of normal

 -  Creatinine less than or equal to 1.5 mg/dL OR creatinine clearance greater than 45
 mL/min/1.73 m(2) for patients with creatinine levels above institutional normal.

 -  Activated partial thromboplastin time (PTT) less than 1.25 times the institutional
 upper limits of normal

 -  Prothrombin Time (PT) OR INR less than 1.25 times the institutional upper limits of
 normal

 -  Amylase and Lipase less than or equal to the institutional upper limit of normal

 -  Spot Urine Protein Creatinine Ratio less than 0.5; If result is 0.5 or more, a 24-hour
 urine for protein excretion must be less than 1000mg

 Patients must have recovered from toxicity related to prior therapy to at least CTEP grade
 1 (defined by CTC 3.0). Chronic stable grade 2 peripheral neuropathy secondary to
 neurotoxicity from prior therapies may be considered on a case by case basis by the
 Principal Investigator.

 Women of child-bearing potential and men must agree to use adequate contraception
 (abstinence; hormonal or barrier method of birth control) for the study and at least 2
 months after completion. Pregnant women will not be eligible for study.

 Ability to understand and the willingness to sign a written informed consent document.

 EXCLUSION CRITERIA:

 Brain metastases

 -  Patients who have a history of remote CNS metastases that have undergone "curative
 therapy" by radiation therapy, gamma knife therapy, or surgery and have remained
 without recurrence for a period of greater than or equal to 2 years will be considered
 on a case-by-case basis.

 -  CNS imaging will not be mandated for all patients. However, if there is clinical
 suspicion of CNS involvement, a contrast CT or MRI of the brain will be required.
 Screening CNS scans should be required for certain tumor types with relatively high
 risk of CNS metastases, including but not limited to melanoma, RCC, breast, lung.

 Thrombotic or embolic events within the past 6 months such as a cerebrovascular accident
 (including transient ischemic attacks), pulmonary embolism, unstable angina, or myocardial
 infarction.

 Uncontrolled intercurrent illness including, but not limited to, ongoing or active
 infection, symptomatic congestive heart failure (AHA Class II or worse), unstable angina
 pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit
 compliance with study requirements.

 -Patients with evidence of active infection will become eligible for reconsideration 7 days
 after completing antibiotic therapy.

 HIV-positive patients receiving combination anti-retroviral therapy are excluded from the
 study because of possible pharmacokinetic interactions with BAY 43-9006, bevacizumab,
 and/or the combination.

 Patients who have been treated with BAY 43-9006 or bevacizumab will be excluded

 Hypertension defined as systolic blood pressure greater than 140 mmHg or diastolic pressure
 greater than 90 mmHg despite optimal medical management.

 Proteinuria defined as a 24-hour urine protein excretion greater than 1000 mg. Spot urine
 analysis for protein creatinine ratio (UPC) of 0.5 or greater will require a 24-hour urine
 to determine eligibility for enrollment.

 Therapeutic anticoagulation with coumadin, heparins, or heparinoids.

 Serious non-healing wounds (including wounds healing by secondary intention), acute or
 non-healing ulcers, or bone fractures within 3 months of fracture. History of abdominal
 fistula, gastrointestinal perforation or intra-abdominal abcesses within 28 days will be
 excluded.

 Evidence of bleeding diathesis

 Impairment of swallowing that would preclude administration of BAY 43-9006.

 History of hemoptysis or surgery within the past 28 days.

 Patients with squamous cell carcinoma of the lungs will be excluded due to risk of fatal
 pulmonary hemorrhage. If a patient has a history of any type primary lung cancer and
 hemoptysis, they will be excluded.

 History of high grade varices.

 Use of herbal supplements are not permitted within 14 days of trial commencement and on
 study. Vitamin supplement (above a typical single multi-vitamin) usage is discouraged
 unless clearly indicated by an existing medical condition. An Associate or Principal
 Investigator will have the discretion regarding which vitamin supplements are permitted.

 Patients with known hypersensitivity to Chinese hamster ovary cell products or other
 recombinant human antibodies.