Registro Malattia Diverticolare (Registry of Diverticular Disease)
Registro Malattia Diverticolare (Registry of Diverticular Disease)
To determine the clinical characteristics and risk factors for the onset of diverticular
 disease and its complications in the Italian population.
Diverticulosis and diverticular disease present a high prevalence rate in the world
 population, especially in the Western world. Diverticulosis of the colon is an extremely
 common condition in industrialized countries and its prevalence rate increases with age, and
 exceeds 60% in patients aged over eighty. Although the course of diverticulosis is normally
 free of symptoms and complications, about 15% of patients develop symptoms often
 undistinguishable from those of the irritable bowel syndrome, such as abdominal pain, bowel
 disorders and bloating. About 5% of patients with diverticular disease develop an episode of
 uncomplicated acute diverticulitis with abdominal symptoms accompanied in some cases by
 systemic symptoms, such as fever or malaise and laboratory evidence of activation of the
 inflammatory process. In a minority of these cases, the patient suffers major complications
 such as the development of abscesses, fistulae, haemorrhage or stenosis (1).

 The pathogenesis of diverticulosis and diverticular disease remains unclear. Genetic
 predisposition, risk factors (2), relationships with the irritable bowel syndrome (3-5), a
 low-fibre diet, involvement of intestinal microbiota and the mucosal immune activation (6-7)
 remain elements whose significance is yet to be confirmed. The management, medical and
 surgical approach and the prevention of relapses of diverticular disease remain above all
 empirical and supported by few controlled clinical studies (8-9). This scenario of
 uncertainty may result in waste and diagnostic/therapeutic pathways not always suitable for a
 disease with such a high prevalence rate. On the basis of these considerations, there is a
 need to collect systematic information useful for determining aetiopathogenetic aspects and
 outcomes with greater accuracy.

 OBJECTIVES OF THE STUDY

 The purpose of the study is to structure a national register on an IT platform useful for
 determining:

 1. The clinical aspects of diverticulosis/ diverticular disease

 2. The risk factors of diverticulosis/ diverticular disease

 3. The risk of complications of diverticular disease and the factors of risk and protection
 against complications.

 4. The management of medical and surgical treatments
Inclusion Criteria:

 All consecutive patients satisfying the following inclusion criteria are recruited:

 1. Acceptance to sign the Informed Consent form

 2. Age >18

 3. Instrumental evidence (endoscopic or radiological) of diverticula in the colon.

 Exclusion Criteria:

 1. Refusal to sign the Informed Consent form

 2. Inability to comply with the study procedures