Does IV Acetaminophen Reduce Opioid Requirement in Pediatric Patients With Acute Sickle Cell Crises?
Does IV Acetaminophen Reduce Opioid Requirement in Pediatric Patients With Acute Sickle Cell Crises?
The purpose of this study is to determine whether IV acetaminophen can decrease the need for
 subsequent opioid administration in the acute management of sickle cell crisis pain in the
 pediatric emergency room.
This is a single-center, prospective, randomized, double-blinded, controlled study in an
 academic urban pediatric emergency department of children with sickle cell disease presenting
 with acute sickle cell crisis pain between ages of 4 to 16 years, with a pain score of 6/10
 or higher on the Wong-Baker modified FACES pain scale. In order to detect a difference of 0.2
 mg/kg in cumulative dosage of morphine (at our institution, 0.3 mg/kg morphine deems an
 inpatient admission for parenteral pain management) with 80% power and alpha of 0.05, we
 calculated a sample size of 33 patients in each group. All patients will receive IV ketorolac
 and IV morphine. Patients will be randomized to receive IV acetaminophen or IV saline
 (volume-equivalent). Pain scores will be obtained at baseline, and again at 30 minutes, 60
 minutes, 90 minutes, and 120 minutes after medication administration. Cumulative morphine
 dosing, rates of admission, and rates of adverse effects of morphine will also be analyzed.
 Our primary objective is to decrease the need for subsequent opioid administration. Our
 secondary objectives are to determine if IV Acetaminophen decreases pain score at 30 minutes,
 60 minutes, 90 minutes, and 120 minutes, decreases the rate of admissions, and decreases the
 rate of adverse effects from opioids.
Inclusion Criteria:

 -  Any patient age 4-16 years with sickle cell disease who presents the Pediatric ER with
 acute sickle cell pain crisis with a pain of 6/10 or higher

 Exclusion Criteria:

 -  Patient with fever (38C or 100.4F)

 -  Patient less than age 4 years

 -  Patient greater than age 16 years

 -  Patient with hypersensitivity/allergy to either morphine, NSAIDs, or acetaminophen

 -  Patient received acetaminophen within the past 4 hours

 -  Patient with known liver disease or renal disease

 -  Patient not requiring IV morphine (pain score 5/10 or less)

 -  Patient enrolled in the study within the past 72 hours