Investigation of Cognitive Function Before and After Induced Ventricular Fibrillation in Electrophysiological (EP) Study
Investigation of Cognitive Function Before and After Induced Ventricular Fibrillation in Electrophysiological (EP) Study
In this study, changes in electroencephalogram (EEG) and the hemodynamic state during
 ventricular fibrillation or induced ventricular tachycardia are investigated.
Patients with a high risk of malignant tachyarrhythmia are routinely investigated by
 programmed electrophysiological study (EPS). To investigate the hemodynamic effects of
 ventricular arrhythmia to cerebral circulation an EEG and transcranial ultrasound are
 conducted simultaneously during the EPS. Before and after the EPS a neuropsychological test
 and an investigation of a specific blood sample (Neuron Specific Enolase, NSE) is done.
Inclusion Criteria:

 -  Age > 18 years

 -  Positive agreement

 -  EPS for primary and secondary prophylaxis of a malignant ventricular tachyarrhythmia:

 -  primary prophylaxis: Brugada syndrome, long QT syndrome, cardiomyopathy, short QT
 syndrome

 -  secondary prophylaxis: Multicenter Automatic Defibrillator Implantation Trial
 (MADIT) criteria, syncope, documented ventricular tachycardia

 Exclusion Criteria:

 -  Severe neurological deficit

 -  Cardiopulmonary resuscitation