Comparison of HES 130 in Balanced and in Unbalanced Solution
Comparison of HES 130 in Balanced and in Unbalanced Solution
The purpose of this study is to evaluate the efficacy of HES 130/0.42 in an electrolyte
 infusion in comparison to HES 130/0.4 in a sodium chloride infusion.
Inclusion:

 -  Male or female (non pregnant) patients; between 18 and 70 years

 -  Elective non-cardiac surgery (except pancreatic or neurological surgery) with an
 estimated operation duration of 2 hours or longer

 -  General anesthesia

 -  Voluntary consent

 Exclusion:

 -  Patients of ASA-class III or IV, Cardiac insufficiency NYHA classes III. IV

 -  BMI < 18 or > 29

 -  Patients with daily urine output < 1L

 -  Patients on hemodialysis

 -  Abnormal liver or renal function (i. e. above upper limit of normal range)

 -  Abnormal coagulation function (prothrombin time (PT) 3 seconds higher than normal or
 activated partial thromboplastin time (APTT) 10 seconds higher than normal)

 -  Hgb < 10g/dl or HCT < 30%

 -  Potassium, sodium or chloride above the upper limit of normal of the laboratory

 -  History of diabetes mellitus

 -  Known history of a mental or neurological disorder, such as epileptic seizures.

 -  History of hypertension and/or taking a beta-receptor blocker or history of atrial
 fibrillation

 -  Patients with known hypersensitivity and with contraindications to HES or any of the
 excipients