Role of Ultrasound-Guided Lymph Node Biopsy in Axillary Staging of Breast Cancer.
Role of Ultrasound-Guided Lymph Node Biopsy in Axillary Staging of Breast Cancer.
The purpose of the study is to estimate the diagnostic accuracy of preoperative
 ultrasound-guided axillary lymph node biopsy for staging in patients with newly diagnosed
 breast cancer, and also to compare between ultrasound-guided fine needle aspiration cytology
 and core needle biopsy in their ability to detect metastatic disease in the axillary lymph
 nodes of patients with breast cancer.
Axillary lymph node status is an extremely important prognostic factor in the assessment and
 treatment evaluation of patients with newly diagnosed breast cancer. Historically, axillary
 lymph node dissection (ALND) has been the reference standard for diagnosis and staging.
 However, this procedure can cause numerous postoperative problems, such as lymphedema , pain,
 impaired shoulder mobility and arm weakness. Furthermore, in this era of mammographic
 screening, axillary lymph node dissection yields negative results in 80%-85% of patients with
 T1 cancer.

 Therefore, in recent years, sentinel lymph node biopsy (SNB) has replaced axillary dissection
 for lymph node staging at major medical centers. However, there are some practical issues to
 be resolved. For example, radiotracer distribution can be slow or faulty, valuable operating
 room time is expended, and pathologists must make quick decisions based on the analysis of
 frozen sections or there is the need to undergo two surgical interventions (i.e., removal of
 primary tumor and SNB, and in a next step completion ALND). If nodal positivity could be
 proven and documented preoperatively, sentinel lymph node biopsy could be bypassed and a
 decision will be made to perform axillary dissection, which is the standard of care in most
 node-positive patients.
Inclusion Criteria:

 -  Newly diagnosed patients with operable breast cancer regardless of whether lymph nodes
 are suspicious or not.

 Exclusion Criteria:

 -  Patients who had previously undergone axillary surgery.

 -  Patients with metastatic disease and not planned for axillary surgery.

 -  Patients with a preoperative diagnosis of a benign lesion or ductal carcinoma in situ.

 -  Patients with severe uncorrectable bleeding diathesis.

 -  Patients refused to sign consent.