Comparison of Medical Therapies in Marfan Syndrome.
Comparison of Medical Therapies in Marfan Syndrome.
The investigators are looking at the different impacts of atenolol, verapamil and perindopril
 on large artery and lv function in marfan syndrome. It is a double-blind, randomised
 cross-over trial.
The investigators recruited 21 patients with confirmed diagnosis of Marfan syndrome from two
 centres. The investigators performed radial artery applanation tonometry and pulse wave
 analysis to derive central aortic pressure and haemodynamic indexes pre-and post
 administering Atenolol 75mg, Perindopril 4mg and Verapamil 240mgs each for four weeks with a
 two week wash-out between medications. All patients underwent detailed functional and
 anatomical echocardiographic assessments at each visit.

 Inclusion criteria were ages 16-60 years with no treatment or β-blocker or other monotherapy
 only for Marfan syndrome. Patients with previous aortic dissection or aortic surgery, severe
 valvular regurgitation, aortic diameter at the sinotubular junction ≥ 5.0cm,
 contraindications to specific drug treatment, e.g. asthma and β-blocker, or those who were
 pregnant or at risk of pregnancy were excluded.
Inclusion Criteria:

 -  Ages 16-60 years old with no treatment or β-blocker or other monotherapy only for
 Marfan syndrome

 Exclusion Criteria:

 -  Previous aortic dissection or aortic surgery

 -  Severe valvular regurgitation

 -  Aortic diameter at the sinotubular junction ≥ 5.0cm

 -  Contraindications to specific drug treatment, e.g. asthma and β-blocker

 -  Those who were pregnant or at risk of pregnancy