VisionRT-based Deep Inspiration Breath-hold (DIBH) Respiratory Motion Management Strategy, A Pilot Study for Thoracic and Abdominal Tumors
VisionRT-based Deep Inspiration Breath-hold (DIBH) Respiratory Motion Management Strategy, A Pilot Study for Thoracic and Abdominal Tumors
A more recent competing technology for implementing the DIBH technique is real-time surface
 photogrammetry using the AlignRT system (Vision RT Ltd., London, UK). AlignRT system use
 non-ionization near infrared light to track patient surface motion. The system has one
 projector projecting near infrared optical pattern on patient surface. The optical pattern is
 imaged by optical cameras (two per pod) at ~25 Hz. The user selects a region-of-interest
 (ROI) on the surface and the software calculates and displays the real-time position in six
 degrees (3 translations and 3 rotations) in real-time. Once the patient has matched the
 pre-determined DIBH position (within threshold accuracy), the radiation beam is enabled to be
 turned on for treatment.
VRT-DIBH has already applied to left breast radiotherapy to spare lung and heart. Compared to
 ABC-DIBH, VRT-DIBH has several potential advantages:

 1. VRT monitors patient (surface) position in addition to DIBH signal, while ABC only check
 the tidal volume, which can remain the same even if the patient shifts slightly on the
 couch;

 2. VRT is more cost effective, as patient tubing needs to be replaced daily for ABC;

 3. VRT potentially has advantage on patient compliance, as with ABC breath is forced
 impeded while with VRT breath-hold is voluntary.

 In this study, we renovate the established DIBH motion management strategy by adopting
 AlignRT system. The purpose of this study is to develop, validate, and prove the feasibility
 of VRT-DIBH technique for lung and liver SBRT.
Inclusion Criteria:

 1. Patients must be willing and capable to provide informed consent to participate in the
 protocol.

 2. Patient with presumed pulmonary function capable of holding breath for at least 30
 seconds - later to be confirmed.

 3. All men, as well as women of child-bearing potential must agree to use adequate
 contraception (hormonal or barrier method of birth control; abstinence) prior to study
 entry, and until study imaging is complete. Should a woman become pregnant or suspect
 she is pregnant while participating in this study, she should inform her treating
 physician immediately.

 3.1 A female of child-bearing potential is any woman (regardless of sexual orientation,
 marital status, having undergone a tubal ligation, or remaining celibate by choice) who
 meets the following criteria:

 -  Has not undergone a hysterectomy or bilateral oophorectomy; or

 -  Has not been naturally postmenopausal for at least 12 consecutive months (i.e., has
 had menses at any time in the preceding 12 consecutive months).

 3.2 Patients must be compliant to all required pretreatment evaluations

 Exclusion Criteria:

 1. Pregnant or lactating women, as treatment involves unforeseeable risks to the embryo
 or fetus

 2. Patients are not compliant to all required pretreatment evaluations