Frequency of ICAM-1 Polymorphisms in Obese Subjects
Frequency of ICAM-1 Polymorphisms in Obese Subjects
The genetic contribution to the development of obesity is now well recognized. However
 obesity is a polygenic disease and thus many genes are likely to be involved. This study aims
 to investigate the possible association between specific variants of the gene coding for the
 Intercellular Adhesion Molecule-1 (ICAM-1)and the development of severe obesity in an Italian
 population
Severely obese subjects referred to our institution will be evaluated. For the aim of the
 study, a venous blood sample will be obtained from these subjects and from a group of normal
 weight volunteers. Genomic DNA will be extracted from the blood samples and analysed by
 standard molecular biology techniques.The allelic and genotype frequencies of the two ICAM-1
 variants will be calculated in the obese and control groups. The statistical significance of
 possible differences will be determined
Inclusion Criteria:

 -  Obesity

 Exclusion Criteria:

 -  Associated inflammatory diseases