Antibiotic Resistant Bacteria Among Patients With Severe Intraabdominal Infections
Antibiotic Resistant Bacteria Among Patients With Severe Intraabdominal Infections
The objectives of the study were:

 1. To study risk factors for colonization and infection with antibiotic resistant bacteria
 among patients with severe IAI before and after antibiotic treatment and surgical
 intervention.

 2. To study species changes in the rectal flora among patients with severe IAI before and
 after antibiotic treatment and surgical intervention.

 3. To review guidelines for antibiotic use in participating units.

 4. To evaluate surgical antibiotic prophylaxis and treatment in relation to risk for
 colonization and infection with antibiotic resistant bacteria among patients with severe
 IAI

 5. To use the results from the study in the process of a more appropriate use of
 antibiotics in participating units and care of patients with severe IAI.

 6. To study the dynamics of extended-spectrum beta-lactamase producing and wild-type
 Enterobacteriaceae in patients with suspected severe intra abdominal infections before,
 during and after antibiotic treatment.
In order to evaluate if standard empirical treatment was adequate in relation to resistance
 pattern among most prevalent species at admission we need another 70 patients to be included
 with at least data and cultures from admission.
Inclusion Criteria:

 -  Patients with evidence of intra-abdominal infections that require surgical
 intervention will be eligible.

 -  In addition will patients with intra-abdominal abscess confirmed with CT/ultrasound be
 eligible, but not treated with surgical intervention if estimated to require at least
 5 days antibiotic treatment, with a severity needing initial intravenous
 administration of antibiotics.

 Exclusion Criteria:

 -  Age under 18 years