Evaluation of Thyroid Abnormity Incidence and Thyroid Toxicity During Chemotherapy Among Newly Diagnosed Breast Cancer
Evaluation of Thyroid Abnormity Incidence and Thyroid Toxicity During Chemotherapy Among Newly Diagnosed Breast Cancer
Breast cancer is one of the most common cancers in China. Even though advances in the field
 of breast cancer therapeutics, chemotherapy remains the mainstay therapeutic modality. The
 cytotoxic therapies are generally associated with some immediate or otherwise delayed side
 effects, such as adverse effects on gastrointestinal, hepatic, renal and hematological
 systems. The effect of chemotherapy on endocrine system, however, is comparatively less
 envisaged. Several epidemiological studies show a positive association between plasma thyroid
 hormones levels and breast cancer risk. Thyroid dysfunction is emerging as a variably common
 endocrine toxicity of several anticancer drugs. Due to the scarcity of data on the
 functioning of thyroid gland during chemotherapy in a large scale group, the present study
 was aimed to investigate the incidence of thyroid abnormity in Chinese women with newly
 diagnosed breast cancer, and also the effects of chemotherapy on thyroid gland functions or
 structure in these breast cancer patients undergoing at least four cycles of chemotherapy.
Inclusion Criteria:

 1. Female patients with histologically or cytologically proven primary breast cancer;

 2. Age >18 years;

 3. ECOG Performance Status: 0-2;

 4. Life Expectancy: 3 months or more;

 5. No previous anti-cancer therapy;

 6. Be willing to undergo at least four cycles of anthracycline or taxane-based
 chemotherapy;

 7. Adequate hematological, liver, and kidney functions.

 Exclusion Criteria:

 1. Pregnancy or lactation;

 2. History of other malignancy or secondary breast cancer;

 3. History of thyroid disease;

 4. History of drug addiction or abuse;

 5. History of immunodeficiency disease;

 6. Treatment with drugs capable of influencing thyroid gland functions within 3 months
 prior to study entry;

 7. Nonmeasurable disease such as un-controlled diabetes, severe cardiovascular and
 cerebrovascular diseases;

 8. Current, recent (within 4 weeks prior to study entry), or planned participation in any
 other clinical trials;

 9. Inability to understand and agree to informed consent.