A Randomized, Double-Blind, Comparative Study of Azithromycin Versus Clarithromycin in Combination With Ethambutol for the Treatment of Disseminated Mycobacterium Avium Complex (MAC) Infection in AIDs Patients
A Randomized, Double-Blind, Comparative Study of Azithromycin Versus Clarithromycin in Combination With Ethambutol for the Treatment of Disseminated Mycobacterium Avium Complex (MAC) Infection in AIDs Patients
To evaluate the efficacy and safety of two different doses of azithromycin in combination
 with ethambutol for the treatment of patients with Mycobacterium avium complex (MAC)
 infection, and to determine whether an azithromycin-containing regimen is at least as safe
 and effective as the same regimen containing clarithromycin..
Patients are randomized to receive azithromycin at one of two doses in combination with
 ethambutol or clarithromycin in combination with ethambutol for 24 weeks, after which they
 are evaluated for entry into a maintenance phase of treatment. Clinical, microbiologic, and
 safety assessments are performed every 3 weeks for the first 12 weeks, then monthly for the
 remaining 12 weeks.
Inclusion Criteria

 Patients must have:

 -  HIV seropositivity.

 -  Disseminated MAC.

 -  No MAC therapy between time of last positive blood culture draw and study entry
 (single-agent prophylaxis allowed).

 -  Life expectancy of at least 2 months.

 -  Consent of parent or guardian if below legal age of consent.

 Exclusion Criteria

 Co-existing Condition:

 Patients with the following symptoms or conditions are excluded:

 -  Known hypersensitivity to macrolide antibiotics (erythromycin, azithromycin, or
 clarithromycin) or ethambutol.

 -  Inability to take oral medications.

 -  Condition likely to interfere with drug absorption (e.g., gastrectomy, malabsorption
 syndromes).

 Concurrent Medication:

 Excluded:

 -  Another investigational drug started in the week prior to study entry.

 Prior Medication:

 Excluded:

 -  MAC therapy between time of last positive blood culture draw and study entry (although
 single-agent prophylaxis is allowed).