Comparison of Antipsychotics for Metabolic Problems in Schizophrenia or Schizoaffective Disorder
Comparison of Antipsychotics for Metabolic Problems in Schizophrenia or Schizoaffective Disorder
The study will compare the effectiveness of antipsychotic medications for patients with
 schizophrenia or schizoaffective disorder for whom a medication change may be indicated
 because of an increased risk of cardiovascular disease.
Metabolic abnormalities associated with cardiovascular morbidity and premature mortality are
 more common in patients with schizophrenia than in matched controls. Although there is some
 evidence that patients with schizophrenia have intrinsic abnormalities in lipid and
 carbohydrate metabolism, some antipsychotics (i.e., clozapine, olanzapine, quetiapine, and
 risperidone) are associated with increased rates of metabolic abnormalities that predispose
 patients to cardiovascular disease.

 This is an investigator-initiated clinical trial that will be conducted at 30 research sites
 that are a part of the NIMH Schizophrenia Trials Network.

 The aims of the study are to (1) determine the relative effects of switching to aripiprazole,
 versus continued treatment with olanzapine, quetiapine, or risperidone, on metabolic
 parameters associated with cardiovascular disease, and (2) to determine the effects of
 switching to aripiprazole versus continued treatment with olanzapine, quetiapine, or
 risperidone on the clinical stability of schizophrenic illness.

 This study design is a multi-site, single-blind (rater) randomized controlled trial of 300
 patients with schizophrenia or schizoaffective disorder comparing treatment with the
 following medications: olanzapine, quetiapine, risperidone, and aripiprazole. The study will
 enroll patients with schizophrenia or schizoaffective disorder for whom a medication change
 may be indicated because of an increased risk of cardiovascular disease in spite of adequate
 control of symptoms on their current antipsychotic medication. Patients who are taking
 olanzapine, quetiapine, or risperidone and who have a body-mass index (BMI) greater than or
 equal to 27 and non-HDL cholesterol greater than or equal to 130 mg/dl will be eligible (if
 non-HDL is between 130-139mg/dL, LDL cholesterol must be greater than 100mg/dL). All
 treatments will be open label. Raters will be blinded to treatment assignment. Patients will
 be followed for up to 6 months.
Inclusion Criteria:

 -  Diagnosed with schizophrenia or schizoaffective disorder

 -  Currently treated with olanzapine, quetiapine or risperidone

 -  BMI greater than or equal to 27

 -  Non-HDL cholesterol greater than or equal to 130 mg/dL (if non-HDL cholesterol is
 between 130 - 139 mg/dL, then LDL cholesterol must be greater than 100 mg/dL).

 Exclusion Criteria:

 -  Diabetes (FBS greater than or equal to 126) or treatment with oral hypoglycemic drug
 or insulin

 -  Non-HDL cholesterol greater than 300 mg/dL

 -  Serum triglycerides greater than 500 mg/dL

 -  Patients in the first episode of schizophrenia or schizoaffective disorder

 -  Known hypersensitivity to aripiprazole

 -  On weight loss medications