Fecal Microbiota Transplantation for Irritable Bowel Syndrome
Fecal Microbiota Transplantation for Irritable Bowel Syndrome
Fecal microbiota transplantation (FMT) is a strategy that infuses a fecal suspension
 containing a healthy donor's microbiota into a patient's gut to restore his/her intestinal
 microbiome. FMT has a higher cure rate than standard antibiotic treatment for recurrent
 Clostridium difficile infections,and shows promising results in Inflammatory bowel
 disease（IBD）.However, few studies have evaluated whether FMT is effective to treat Irritable
 bowel syndrome(IBS).The investigators propose to determine the efficiency and safety of FMT
 in patients with Irritable bowel syndrome.
The present clinical trial aims to re-establish a gut functionality state of intestinal flora
 through FMT as a therapy for Irritable bowel syndrome(IBS). We established a standard
 microbiota isolation from donated fresh stool in lab. Then the microbiota is transplanted to
 the whole colon through a tube. Patients from Guangzhou First People's Hospital in this study
 will be assigned to receive FMT at least two times according to associated guidelines and
 follow-up for at least six months. Questionnaires will be used to assess participants at
 study start and at study completion.
Inclusion Criteria:

 To be considered eligible for enrolment into the study, subjects must:

 -  Be able to give written informed consent.

 -  Males and females aged >18 and <75

 -  Have IBS as defined by the Rome IV criteria

 Exclusion Criteria:

 Subjects will be excluded from the study if they meet any of the below criteria:

 -  pregnant or having a follow-up of less than 6 months;

 -  unable to give informed consent;

 -  suffering from other severe disease ,including liver and kidney failure, cancers,
 intestinal diseases, inflammatory bowel disease, C difficile infection;

 -  unable to undergo endoscopy.