Comparison of Transcutaneous Vs End-tidal CO2 Pressure Measurements in Hyperventilation Syndrome Diagnosis
Comparison of Transcutaneous Vs End-tidal CO2 Pressure Measurements in Hyperventilation Syndrome Diagnosis
Hyper Ventilation Syndrome is a frequent disease affecting adults whose diagnosis is often
 belated or even unrecognized due to the lack of "gold standard" criteria. Its diagnosis
 currently relies on the Nijmegen score associated with a PetCO2 assesment using a
 hyperventilation provocation test. Correlation between Nijmegen Questionnaire scores and
 PetCO2 appears highly variable. PtcCO2 monitoring is a noninvasive alternative method
 providing a continuous estimation of arterial CO2 pressure (PaCO2) which could represent an
 advantageous alternative to PetCO2 measurements. Several reports have demonstrated that
 PtcCO2 monitoring reflects more faithfully PaCO2 than PetCO2, no study have evaluated its
 value in this indication.

 The primary aim of the study is to compare the diagnostic value of PtcPCO2 monitoring with
 PetCO2, the method currently used.

 Included patient will be invited to fill in the Nijmegen questionnaire and an ambient air gas
 measurement will be performed. PtcCO2 (mmHg) will be simultaneously measured during
 hyperventilation test. Nijmegen score signs reproduced by the test will be analysed. HVS
 diagnosis will be assessed by usual criteria (PetCO2 <30 mmHg at the end of hyperventilation
 test or under the PetCO2 value at rest, Nijmegen score> 23).

 PtcCO2 data will be blinded interpreted later. We will compare if PetCO2 and PtcCO2 leads to
 the same diagnosis or not.
Primary Goal:

 Show that the use of either of the two pCO2 measurements leads to the same diagnostic
 conclusion in HVS diagnosis with a likelihood greater than 80 %.

 Secondary Outcome Measures :

 Evaluate the correlation between PtcCO2 and PtcCO2 measurements Evaluate tolerance to the
 hyperventilation test

 Inclusion Criteria :

 1. The patient must have reached the age of the civil majority (≥ 18 yo)

 2. All patients refered to the Physiology department of Rouen University Hospital, France,
 for an hyperventilation test

 3. The patient must be a member or beneficiary of a health insurance program

 4. The patient must have given his / her free and informed consent and signed the consent

 Exclusion Criteria :

 1. Sepsis

 2. Hypercapnia (PaCO2 > 50mmHg)

 3. Patient treated by long-term oxygen therapy

 4. Subjects under judicial protection, or adults under any kind of guardianship or under
 judicial control

 5. Pregnancy or breastfeeding women

 6. Electrolytic unbalance

 7. Hyperthyroidism

 8. Neurological disease

 9. Probability of drug-induced hyperventilation (progestagens , aspirin, beta agonists)
Inclusion Criteria:

 1. The patient must have reached the age of the civil majority (≥ 18 yo)

 2. All patients refered to the Physiology department of Rouen University Hospital,
 France, for an hyperventilation test

 3. The patient must be a member or beneficiary of a health insurance program

 4. The patient must have given his / her free and informed consent and signed the consent

 Exclusion Criteria:

 1. Sepsis

 2. Hypercapnia (PaCO2 > 50mmHg)

 3. Patient treated by long-term oxygen therapy

 4. Subjects under judicial protection, or adults under any kind of guardianship or under
 judicial control

 5. Pregnancy or breastfeeding women

 6. Electrolytic unbalance

 7. Hyperthyroidism

 8. Neurological disease

 9. Probability of drug-induced hyperventilation (progestagens , aspirin, beta agonists)