Clinical Effect of the Association of Noninvasive Ventilation and High Flow Nasal Oxygen Therapy in Resuscitation of Patients With Acute Lung Injury (FLORALI Study)
Clinical Effect of the Association of Noninvasive Ventilation and High Flow Nasal Oxygen Therapy in Resuscitation of Patients With Acute Lung Injury (FLORALI Study)
The aim of the study is to compare, in patients with acute respiratory failure/acute lung
 injury the efficacy of three different methods of oxygenation to prevent endotracheal
 intubation :

 1. conventional oxygen therapy (O2 conventional)

 2. high flow nasal oxygen therapy (O2-HFN)

 3. association of high flow nasal oxygen therapy with non invasive positive pressure
 ventilation (O2-HFN/NPPV).
Inclusion Criteria:

 -  Hypoxemic and no hypercapnic acute respiratory failure :

 -  severe dyspnea at rest with a respiratory rate >25 breaths/min

 -  PaO2/FiO2 <300

 -  PaCO2 <45 mmHg,

 Exclusion Criteria:

 -  age <18 years

 -  NPPV contraindications

 -  past history of respiratory chronic disease (COPD, cystic fibrosis…)

 -  cardiac pulmonary edema

 -  Pre-defined intubation

 -  other than respiratory organ failure : systolic pressure <90 mmHg,current treatment
 with epinephrine or norepinephrine, decreased level of consciousness ( Glasgow score ≤
 12)

 -  profound aplasia (white cells count <1000/mm 3)