Effects of Docosahexaenoic Acid (DHA) on Cardiovascular Disease on Diabetic Patients
Effects of Docosahexaenoic Acid (DHA) on Cardiovascular Disease on Diabetic Patients
Aim: to determine the effects of DHA supplementation:

 -  on the platelet function through their aggregation and the pathway of arachidonic acid
 metabolism

 -  on redox status on cells and plasma

 -  on inflammation in 16 type 2 diabetic patients in a cross-over study comparing DHA (400
 mg/day for 2 weeks) vs Sunflower oil (placebo). Each period is separated by a wash-out
 period of 6 to 9 weeks.
Inclusion Criteria:

 -  woman

 -  Type 2 diabetes

 -  Menopausal or aged between 55 and 75 years old

 -  Recent HbA1c between 6.5-10%

 -  Oral anti-diabetic drugs or insulin therapy

 -  Hypertension or antihypertensive drug

 Exclusion Criteria:

 -  Tobacco

 -  Excessive drinking

 -  Post-menopausal hormonal treatment

 -  Treatment by acetylsalicylic acid, clopidogrel, gliclazide, ticlopidine, NSAID

 -  Secondary cardiovascular prevention

 -  antioxidant using

 -  Fish intake >2 times a week

 -  Anemia <10g/L

 -  Thrombopenia <110g/L

 -  Creatinine clearance <30 ml/min and/or proteinuria >1g/L