Ketorolac in Postoperative Infants: Pharmacokinetics and Safety
Ketorolac in Postoperative Infants: Pharmacokinetics and Safety
Infants handle ketorolac differently than adults. Study of handling of this pain medication
 given to infants following surgery. Detailed analysis of how the drug is eliminated from age
 2 months to 18 months. Compared morphine use in infants who received the drug to the group
 getting placebo. Safety testing for kidney and liver function, breathing measured by
 continuous oximetry, and any bleeding issues.
Population kinetic analysis of ketorolac stereo-isomer concentrations after single dose given
 postoperatively in infants aged 2-18 months. Safety assessments of renal and hepatic function
 tests by blood tests before and after drug administration, urinalysis pre- and post-drug,
 continuous oximetry before and for 12 hours after drug. Morphine use between active drug
 groups and placebo group in the first 24 hours after surgery was assessed as a surrogate
 analgesic measure in these non-verbal infants. A modified infant pain scale was used to
 assure consistent pain management.
Inclusion Criteria:

 -  Non-prematurely-born infants admitted to hospital following surgery ages 2-18 months,
 studied by age group 12-18 months, 6-12 months, < 6 months

 Exclusion Criteria:

 -  Bleeding history in infant or family

 -  Coagulopathy

 -  Gastrointestinal bleeding history

 -  Renal or hepatic disease assessed by history and by pre-drug blood tests

 -  Premature birth (<36 weeks gestation)