Perioperative Intravesical Instilation of Hypertonic Saline Following Bladder Tumor Resection
Perioperative Intravesical Instilation of Hypertonic Saline Following Bladder Tumor Resection
Hypertonic saline at the concentration of 3% (hypersel) has been injected for years into
 echinococcal cysts to kill live scolices, and is also known to kill suspended cells by means
 of a steep osmotic gradient and the investigators postulate that perioperative intravesical
 instillation of hypersel for patients with low grade bladder cancer is safe and may be active
 against shedded and suspended tumor cells and thus may decrease recurrence risk.
Inclusion Criteria:

 1. Patients of 18 years or older able to sign informed consent

 2. A previous diagnosis of low grade bladder cancer

 3. A pyelographic imaging examination (CTU, MRU, IVP, antegrade/retrograde pyelography)
 showing normal upper urinary tract in the 12 months prior to inclusion

 4. Serum creatinine levels ≤ 2.0 mg/dl

 5. Serum sodium levels <146 mg/ml

 6. Current bladder tumor diagnosed by endoscopy or imaging in the last 3 months

 7. Patient is candidate for TURBT

 Exclusion Criteria:

 1. Previous history of high grade bladder cancer including carcinoma in situ

 2. Presence of upper urinary tract tumor on imaging

 3. Renal failure with serum creatinine >2.0 mg/dl prior to inclusion

 4. Hypernatremia >146 mg/dl prior to inclusion

 5. Contra-indication to undergo TURBT