Can Addition of Doxycycline Perioperatively Reduce Propionibacterium Acnes in Shoulder Arthroplasty?
Can Addition of Doxycycline Perioperatively Reduce Propionibacterium Acnes in Shoulder Arthroplasty?
The purpose of this study is to investigate antibiotic treatment to target bacteria about the
 shoulder. This bacteria, Propionibacterium acnes, is detected in many revision shoulder
 surgeries and is thought to contribute to periprosthetic joint infections, pain, and failure
 of total shoulder arthroplasty as well as other shoulder surgeries. This study is
 investigating adding an FDA approved antibiotic that is commonly used for treatment of this
 bacteria and many common infections. The investigators will take intraoperative cultures to
 look for the presence or absence of specific bacteria. The investigators are conducting this
 trial to see if adding another antibiotic to specifically target this common bacteria found
 around the shoulder will be effective.
Patients undergoing total and reverse shoulder arthroplasty for primary glenohumeral
 arthritis will be invited to participate in this study if patients meet inclusion and
 exclusion criteria. Patients will be randomized to receive either standard perioperative
 antibiotics with cefazolin or to the treatment group to receive doxycycline in addition to
 cefazolin. Patients will then undergo routine surgical treatment. 3 cultures from the
 superficial tissue, dermis, and glenohumeral joint will be taken and cultured for 14 days to
 detect any bacterial growth.
Inclusion Criteria:

 -  Patients undergoing primary total shoulder arthroplasty at Rush University Medical
 Center

 Exclusion Criteria:

 -  Patients with prior shoulder surgery of any kind

 -  Patients with a known infection or history of infection with clinical signs such as
 elevated erythrocyte sedimentation rate, C-reactive protein, positive culture
 aspiration

 -  Patients with a known allergy to doxycycline

 -  Patients with a known allergy to cefazolin or penicillin