Once Versus Twice Daily Iron Supplementation in Pregnant Women
Once Versus Twice Daily Iron Supplementation in Pregnant Women
The investigators will randomize women diagnosed with anemia in the mid-trimester of
 pregnancy to once or twice daily iron supplementation
Women defined as having iron deficiency anemia based on a low hemoglobin as defined by the
 American College of Obstetrics and Gynecology and a low serum ferritin, in the absence of
 hemoglobinopathy, will be randomized to ferrous sulfate 325mg PO daily or PO twice daily.
Inclusion Criteria:

 -  Singleton gestation

 -  Iron deficiency anemia as defined by a Hgb of less than 11mg/dL in the first and 3rd
 trimester and 10.5mg/dL in the 2nd trimester and a serum ferritin of less than
 15ug/mL.

 -  In accordance with American College of Obstetricians and Gynecologists (ACOG)
 guidelines, the Hgb cutoff will be reduced by 0.8mg/dL in African American women.

 -  In accordance with the standard of care, African American women and those with a mean
 corpuscular volume (MCV) on their routine screening complete blood count (CBC) of less
 than 70 will require a hemoglobin electrophoresis to exclude hemoglobinopathy prior to
 enrollment.

 Exclusion Criteria:

 -  Multiple gestation

 -  Maternal hemoglobinopathy or hemochromatosis,

 -  Irritable bowel disease or irritable bowel syndrome

 -  History of bariatric surgery or extensive bowel surgery

 -  Individuals already receiving iron supplementation aside from prenatal vitamins.