The Maximum Tolerated Dose of Mesenchymal Stem Cells From Umbilical Cord
The Maximum Tolerated Dose of Mesenchymal Stem Cells From Umbilical Cord
The aim of this study was to evaluate the maximum tolerated dose of Mesenchymal Stem Cells
 (MSCs) from umbilical cord in the treatment of human knee OA
This is a single-centre, quadruple blined, randomized controlled trail with a total of 9 knee
 osteoarthrits patients as participants, who will be randomly assigned into high dose group,
 moderate dose group or low dose group. The participants in the high dose group will receive
 the treatment of high dose MSCs (1×10^8cells/3mL) anticular injection.The dose of the MSCs in
 medium dose group is 5×10^7cells/3mL, and the dose in the low dose group is 1×10^7cells/3mL.
 Unexplained local and systemic symptoms will be assessed to determine the the maximum
 tolerated dose of mesenchymal stem cells in anticular injection.
Inclusion Criteria:

 ① K / L score of 2-3; ② chronic knee pain; ③ no local or systemic infection; ④ without
 obvious contraindication of the joint puncture from hematology and biochemical tests; ⑤
 informed consent. -

 Exclusion Criteria:

 ① older than 75 years old or less than 18 years old, or without full capacity for civil
 conduct; ② HIV, hepatitis virus or syphilis virus infection or their serology is positive;
 ③ BMI index is greater than 30; ④ congenital or acquired knee deformity; ⑤ pregnant or
 lactating women; ⑥ tumor patients; ⑦ immunodeficiency patients; ⑧ intra-articular drug
 injection history within 3 months; ⑨ participating in other clinical trials; ⑩ other
 patients who researchers believe are not eligible for inclusion such as suffering from
 other concomitant diseases.-