Calcitonin Gene Related Peptide-Induced Headache in Patients With Familial Hemiplegic Migraine Type 1 and 2.
Calcitonin Gene Related Peptide-Induced Headache in Patients With Familial Hemiplegic Migraine Type 1 and 2.
The aim of the present study is to explore functional consequences of migraine gene mutations
 on their responses to Calcitonin Gene Related Peptide (CGRP)infusion.
Calcitonin Gene Related Peptide (CGRP) induces migraine attacks indistinguishable from
 spontaneous attacks in approximately 50% of migraine sufferers. Treatment of spontaneous
 migraine attacks with an antagonist to CGRP is effective in many patients. These data show
 that CGRP is involved in both initiation and maintenance of migraine attack.

 The consequence of migraine gene mutations on relevant migraine pathways has never been
 tested. The aim of the present study is to explore functional consequences of migraine gene
 mutations on their responses to CGRP infusion. The project will improve our understanding of
 the neurobiology of migraine and stimulate development of new treatment targets.
Inclusion Criteria:

 Patients: Diagnosis of familial hemiplegic migraine (IHS-classification criteria) caused by
 mutations in the CACNA1A gene and the ATP1A2 gene.

 Controls: Healthy volunteers

 Exclusion Criteria:

 Controls: No primary headache in their own history 2) Patients and controls:

 -  A history of cerebrovascular disease and other CNS- disease

 -  A history of serious somatic and mental disease

 -  A history suggesting ischaemic heart disease

 -  A history of hypo- or hypertension

 -  Daily intake of medication apart from oral contraceptives

 -  Abuse of alcohol or medicine (opioid analgesics).

 -  Pregnant or breastfeeding women.

 On the study day:

 -  No intake of a simple analgesic in the previous 48 hours

 -  No headache in the previous 48 hours