Risk Factors Worsening COVID19 for Out-patient With Home Monitoring
Risk Factors Worsening COVID19 for Out-patient With Home Monitoring
The main objective of the COVIDADOMEVA study is to identify the risk factors aggravating the
 COVID-19 (risk or protective factors), in out-patients suspected of being infected with
 precocious home monitoring.

 The primary event defining the aggravation will be then: hospitalization (medicine,
 resuscitation) or death.

 The studied potential risk factors will be mainly:

 -  Socio-demographic: age, sex, place of residence or income

 -  Comorbidities

 -  Clinical signs: asthenia, dyspnea (kinetics)…

 -  Drugs other than those related to the infection

 For this research project, this study needs to use the patient's data of the COVIDADOM cohort
 (patients suspected of being infected with SARS-CoV-2 with home monitoring) and will collect
 some supplementary data (clinical and biological). All these data will be integrated and
 analyzed in the PREDIMED clinical data lake platform (The implementation of PREDIMED has been
 approved by the French authority in terms of GDPR, CNIL, on October 10, 2019).
In front of the recent emergence of the SARS-CoV-2 coronavirus (COVID) in December 2019 in
 the Wuhan region of China, knowledge of the clinical course and of the aggravating risk
 factors linked to this virus is still incomplete.

 COVID is associated with severe morbidity and an estimated mortality of 2-4% in patients
 without comorbidity. According to a WHO report published on the situation in China, patients
 with serious chronic pathologies, such as diabetes or severe obesity, are particularly
 vulnerable and mortality rates were higher: from 7 to 13%.

 Monitoring and describing the clinical pathway of out-patients suspected of being infected
 according to their medical history should improve knowledge of COVID, and then adapt patient
 care management and control the COVID pandemic.

 Currently, few European studies have described the potential risk factors that could lead to
 the worsening of the disease. Since the March 16th, the university hospital of Grenoble
 (France) has developed an information technology system to monitor out-patients suspected of
 being infected with SARS-CoV-2 coronavirus and with early home monitoring: the COVIDADOM
 cohort

 That's why the COVIDADOMEVA study is then to identify the risk factors aggravating the COVID,
 in out-patients with precocious home monitoring.

 The primary event defining the aggravation will be then: hospitalization (medicine,
 resuscitation) or death

 The studied potential risk factors will be the following:

 -  Socio-demographic: age, sex, place of residence, CSP, and income.

 -  Comorbidities or aggravation: COPD, asthma, immunosuppression, or heart failure,
 diabetes imbalance, etc.

 -  Clinical signs: asthenia, dyspnea (kinetics), blood sugar, nutritional status, weight
 gain…

 -  Drugs other than those related to the infection and potential self-medication
 (anti-inflammatory, CEI, ARA…)
Inclusion Criteria:

 -  Patient with clinical symptomatology suspecting COVID-19, that is to say: severe
 dyspnea, and/or serious extra pulmonary signs (myalgia, diarrhea, etc.) OR

 -  Patient with clinical symptomatology (cough or dyspnea or fever with ENT signs) AND at
 least one of the following comorbidities: COPD stage 1 or 2 (dyspnea usually absent or
 for marked efforts), Asthma with daily inhaled corticosteroid therapy,
 Immunosuppression or cancer during chemotherapy, Coronary history, Heart failure
 (Stages 2 and 3, dyspnea with moderate or low effort), Obesity (BMI> 30), Type 1 or 2
 diabetes, cirrhosis from Child B, pregnant woman in the 3rd trimester.

 -  Patient with a phone monitoring of at least more than 2 calls, if no aggravation of
 disease.

 Exclusion Criteria:

 -  Person deprived of liberty by judicial or administrative decision

 -  Person being subject to a legal protection measure

 -  Person who expressed opposition to participating in the COVIDADOMEVA study