Clinical Studies of Kikuchi's Disease
Clinical Studies of Kikuchi's Disease
Kikuchi-Fujimoto disease is a distinctive syndrome of necrotizing lymphadenitis which was
 formally described in 1972 by two Japanese pathologists, Kikuchi and Fujimoto. It is a
 benign, self-limited disease that predominantly occurs in young women. It was more common in
 Asian people, especially in Japanese. The most frequent clinical presentations are fever
 (30~50%) and cervical lymphadenopathy, often tender in palpable. Other lymph node regions can
 be affected, and hepatosplenomegaly may be present. The laboratory findings include
 leucopenia with atypical lymphocytosis. ESR, transaminases and lactate dehydrogenase are
 often raised. The clinical features are easily confused with other conditions, particularly
 lymphoma. Therefore the diagnosis depends on the pathological findings. The typical findings
 are paracortical lesions consisting of patchy zones of eosinophilic fibrinoid necrosis and
 abundant karyorrhexis. In general, spontaneous resolution of symptoms and signs within a few
 months can be expected without treatment.For decades, the etiology of Kikuchi's disease has
 been speculated. Although the perforin and Fas pathways of cytotoxic T cells induce an
 abundance of apoptosis and thus induce necrotizing lesions, the trigger factor is unknown.
 Since the disease can precede or occur in association with a connective tissue disorder,
 especially SLE, the autoimmune contribution to the etiology has also been speculated.
 However, the clinical course of Kikuchi's disease, often sudden onset and spontaneous
 resolution, the frequent flu-like or upper respiratory prodrome, and the prominence of
 cervical lymphadenopathy, support a viral cause. Evidence for a viral cause also includes
 peripheral blood atypical lymphocytosis and elevated serum IFN-a or 2'-5' oligoadenylate
 synthetase levels. Several infectious agents have been suggested, including bacteria (e.g.
 Brucella, Yersinia), parasites (e.g. toxoplasmosis) and viruses (e.g. EBV, CMV, HHV6, HHV8,
 parvovirus B19, HTLV, HIV).The aim of this study is to collect cases of Kikuchi' disease in
 bureau of NHI and NTUH. We will analyze the incidence rate, age of onset, sex, season of
 onset and clinical course to see if there is any clustered cases, or nosocomial infection.
 Then we will study the etiology of Kikuchi's disease especially the infection causes by
 analyzing pathologic specimen and serology. We hope to find out the etiology of Kikuchi's
 disease and the new treatment.
Inclusion Criteria:

 -  Kikuchi's disease