Local Hyperthermia for the Treatment of Cervical Intraepithelial Neoplasias
Local Hyperthermia for the Treatment of Cervical Intraepithelial Neoplasias
Human papillomavirus(HPV) infect epithelial cells and have the capacity to stimulate cell
 abnormal hyperplasia, especially by those high-risk HPV types. HPV vaccine primarily
 targeting HPV6/11/16/18 has been available and makes it possible to prevent cervical cancer.
 However, a large population was left unvaccinated, specifically for those aged ones. In
 clinic, patients harboring high-risk HPV is quite prevalent in China or other developing
 nations. Removing the virus and prevention of malignant transformation is required.

 Mild local Hyperthermia with a certain temperature range has been successfully used in the
 treatment of some diseases. It has been utilised in the treatment of some neoplasm, fungal
 and HPV infections. Investigators' study found that local hyperthermia at 44°C could cleared
 HPV in more than half of the patients with plantar warts. Investigators also note the fact
 that in patients with multiple lesions, the clearance of the target lesion is commonly
 followed by clearance of other distant lesions, a phenomenon suggesting that local
 hyperthermia could aid in establishing a specific immune response to eliminate HPV.So the
 purpose of the study is to evaluation local hyperthermia in the treatment of cervical
 intraepithelial neoplasias grade I and II after 3 months, with positive high-risk type HPVs,
 and patients with positive testing for high risk HPVs. Appropriate control arms were designed
 for different conditions.
Mild local Hyperthermia with a certain temperature range has been successfully used in the
 treatment of some diseases. It has been utilised in the treatment of some neoplasm, fungal
 and HPV infections. Investigators' study found that local hyperthermia at 44°C could cleared
 HPV in more than half of the patients with plantar warts. Investigators also note the fact
 that in patients with multiple lesions, the clearance of the target lesion is commonly
 followed by clearance of other distant lesions, a phenomenon suggesting that local
 hyperthermia could aid in establishing a specific immune response to eliminate HPV.So the
 purpose of the study is to evaluation local hyperthermia in the treatment of cervical
 intraepithelial neoplasias grade I and II after 3 months, with positive high-risk type HPVs,
 and patients with positive testing for high risk HPVs. Appropriate control arms were designed
 for different conditions. One control arm is local hyperthermia at 37°C for 30 mins targeted
 for CINⅠ, the other control arm is LEEP targeted for CINⅡ. After 3 months, to evaluate the
 effectivity of local hyperthermia.
Inclusion Criteria:

 -  18-65 years old; generally healthy gynecological conditions, normal sexual life; high
 risk HPV; Cervical biopsy CIN or no cytological changes; signed informed consent

 Exclusion Criteria:

 -  Pregnant woman;local or systematic treatment within 3 months; Comorbidity of other
 severe gynecological inflammation, infection, or tumor; Comorbidity of other serious
 illnesses； no guarantee of timely treatment and follow-up