Stereophotogrammetry of the Torso in Healthy Individuals and Patients With Scoliosis, Chest Wall Deformations, or Obesity
Stereophotogrammetry of the Torso in Healthy Individuals and Patients With Scoliosis, Chest Wall Deformations, or Obesity
Background:

 - Stereophotogrammetry (SP) uses four sets of digital cameras to generate a three-dimensional
 computer image. Unlike other types of evaluations which require radiation, SP only uses
 computer images to learn more about physical deformities such as scoliosis or about the
 placement of fat on the body. To refine the SP process, researchers are interested in
 collecting images and body data from individuals with skeletal structural problems such as
 scoliosis or chest wall deformities, individuals who are overweight or obese, and healthy
 volunteers.

 Objectives:

 - To use stereophotogrammetry to study different individual body types and refine existing
 imaging techniques.

 Eligibility:

 - Individuals at least 2 years of age who have spine, rib, or chest wall deformities; are
 overweight or obese (body mass index greater than 25); or are healthy volunteers.

 Design:

 -  Participants will be screened with a physical examination and medical history. The
 physical examination will include measurements of range of motion and joint mobility,
 torso width and length, and other observational data.

 -  Healthy volunteers and participants in the obesity group will also have bioelectric
 spectroscopy (bioimpedance), which uses an additional machine to measure how fat is
 spread in different parts of the body.

 -  After the physical examination has been completed, participants will have SP photographs
 taken. Participants will be asked to remove all clothing from the torso, stand with arms
 raised at the center of four cameras, and remain still while several images are taken. A
 complete image takes less than 1 second.

 -  Participants with spine or rib deformities, or who are in the obesity group, may also
 volunteer to return for followup SP imaging, once a year for 5 years, to study progress
 over time.
OBJECTIVE:

 The primary objective of this project is to determine which outcome measures derived from
 analysis of SP images are reliable within the healthy population and can distinguish between
 healthy volunteers and those with scoliosis, chest wall deformities, and obesity. Secondary
 objectives include comparing SP outcome measures with clinical and radiographic measures to
 test concurrent validity and to determine if the SP outcome measures correlate with clinical
 and radiographic measures taken over time. The ultimate goal is to develop SP as a
 measurement tool to be employed in clinical research involving the study of scoliosis, rib
 and chest deformities and the truncal distribution of adiposity.

 STUDY POPULATION:

 The population for this study consists of healthy volunteers, persons with scoliosis and/or
 chest wall deformities, and persons with obesity. Men and women of all races, ethnicities,
 and ages greater than two years may participate.

 DESIGN:

 This project will be carried out in three phases. In Phase I, we will analyze images of
 healthy volunteers captured by the SP scoliosis and chest-wall deformity ( scoliosis )
 software to identify the outcome measures that show minimal or no variance. We will also
 examine if healthy volunteers gender, age, height, and BMI contribute to the differences of
 these outcome measures.

 In Phase IIa, images captured from subjects with scoliosis and/or chest wall deformities will
 be processed by scoliosis software to determine the set of meaningful variables (those that
 show significant differences between the two populations). In Phase IIb, images captured of
 healthy volunteers will be processed using obesity software to determine the set of variables
 showing minimal or no variance among the data from healthy volunteers when controlling for
 the effects of potential confounders. Variables that continue to have minimal or no variance
 will be considered meaningful with respect to obesity analysis software. Those variables
 achieved from obesity image analysis will be compared to the set from the healthy volunteers
 to determine which variables show significant differences between the healthy volunteer and
 obese subjects.

 In Phase III, healthy participants, scoliosis/chest wall deformity, and obesity participants
 who are scheduled to return to NIH as part of another NIH protocol will be invited to return
 for yearly re-imaging up to a total of five years in order to analyze changes over time and
 compare them with concurrent radiographic measures.

 OUTCOME MEASURES:

 The purpose of the study is to develop outcome measures for use in future research. These
 outcome measures will be developed from software which analyzes images derived from the
 stereophotogrammetry system.
-  INCLUSION CRITERIA:

 -  All subjects greater than 2 years of age, genders, and ethnicities will be
 eligible so long as they can cooperate with physical examination and imaging
 procedures.

 -  Subjects must be able to stand independently for imaging. This limits enrollment
 to subjects 2 years of age and older.

 -  Subjects must agree to capture of image of their bare torso above the waist

 -  Healthy volunteers must be without scoliosis, or chest wall deformities, and with
 BMI below overweight range. For adults, BMI must be less than or equal to 25. BMI
 for children and adolescents will be corrected according to the guidelines
 designated by the Centers for Disease Control and Prevention found in Appendices
 2 (boys) and 3 (girls).

 -  Adults with BMI less than or equal to 25 and children and adolescents with adjust
 BMI below the overweight range AND with imaging confirmed scoliosis and/or chest
 wall deformities will be recruited from participants in NIH intramural protocols
 or referred by outside physicians and will be eligible to participate in phase
 IIa of the study.

 -  Adults (subjects who are 18 years of age or older), must either present a
 previously obtained clinical standing scoliosis xray film dated no more than
 12 months prior to the study visit or obtain a scoliosis series x-ray at the
 National Institutes of Health Clinical Center to provide confirmation of
 scoliosis. Therefore, xrays may be done for research purposes in adults if
 there is prior imaging indication but no scoliosis series xray films taken
 within the last 12 months.

 -  Children must present a previously obtained clinical standing scoliosis film
 dated no more than six months prior to the study visit to provide
 radiological confirmation of scoliosis. No xrays will be done for research
 purposes.

 -  Volunteers who have undergone spinal fusion surgery must show a
 postoperative film that shows that the instrumentation is intact and that
 desired spinal fusion has occurred. Xrays may be done for research purposes
 in adults if there is prior imaging indication but no scoliosis x-ray series
 films taken within the last 12 months.

 -  Subjects with BMI greater than 25 (or for children and adolescents defined
 according to Centers for Disease Control and Prevention guidelines as
 "overweight") AND without deformities of the torso will be eligible to
 participate in phase IIb, the obesity portion of the study.

 -  Subjects with deformities of the torso OR with BMI greater than 25 may be
 eligible to participate in Phase IIIa or IIIb and be followed yearly over the
 course of five years

 -  Subjects with scoliosis and/or chest wall deformities that are followed over
 the course of the five years must provide clinically obtained films with at
 least a difference of a year between the current and previous films. In
 adults, if the curve changes, it is clinically indicated to get a follow-up
 film and subsequent scoliosis xray films may be taken at the NIH CC. Those
 who do not require clinical films cannot be included in the scoliosis/chest
 wall deformities group followed over time.

 -  For subjects of BMI greater than 25, volunteers will be invited to be
 followed over time using SP if they have a change in their body composition
 over time (if they have not yet attained physical maturity, if they
 participate in weight loss program, or report a significant weight gain).

 EXCLUSION CRITERIA:

 -  Subjects unable to tolerate having points on the torso marked with a surgical ink
 marker

 -  Subjects with contact or respiratory isolation status

 -  Subjects with pacemakers or other electrical or conducting metal medical devices
 implanted in their torso will not be able to participate in the normal volunteer and
 obesity groups due to contraindication to participation in bioelectric spectroscopy
 testing.

 -  Subjects with electrical or conducting metal medical devices in their arms or legs
 that are not limited to one side of the body will not be able to participate in the
 normal volunteer and obesity groups because it will cause data distortion in the
 bioelectric spectroscopy testing.

 -  Subjects who are unable to tolerate stroboscopic camera flash

 -  Subjects who are employees/staff of the NIH Clinical Center Rehabilitation Medicine
 Department.