Ruxolitinib With Radiation and Temozolomide for Grade III Gliomas and Glioblastoma
Ruxolitinib With Radiation and Temozolomide for Grade III Gliomas and Glioblastoma
The purpose of this study is to test how well the drug works, safety and tolerability of an
 investigational drug called Ruxolitinib in gliomas and glioblastomas, when combined with
 standard treatment for brain cancer, temozolomide and radiation.

 Ruxolitinib is an experimental drug that works by targeting proteins in cells and stops them
 from growing. Ruxolitinib is experimental because it is not approved by the Food and Drug
 Administration (FDA) for the treatment of gliomas or glioblastomas

 Temozolomide works by damaging the DNA of tumor cells so that they cannot divide properly.
 Some tumor cells can repair that damage and therefore be resistant to temozolomide.
Primary Objective

 Arm 1:

 To determine Maximum tolerated dose (MTD) of ruxolitinib with radiation (2 Gy x 30) in
 patients with unmethylated MGMT high-grade glioma (HGG)

 Arm 2:

 To determine Maximum tolerated dose (MTD) of ruxolitinib with radiation (2 Gy x 30) and daily
 temozolomide at 75 mg/m2 in patients with methylated MGMT high-grade glioma (HGG)

 Secondary Objective(s)

 Arm 1:

 -  Safety of combination of ruxolitinib with radiation

 -  Progression free survival (PFS)

 -  Overall survival (OS)

 Arm 2:

 -  Safety of combination of ruxolitinib with radiation and temozolomide

 -  Progression free survival (PFS)

 -  Overall survival (OS)

 STUDY DESIGN

 A phase 1 design will be used with cohorts of 3 patients treated at each dose level in both
 arms 1 and 2 and monitored for treatment-related toxicities. Escalation to the next dose will
 proceed in the absence of dose-limiting toxicities (DLTs).
Inclusion Criteria:

 Arm 1:

 -  Patients must have unmethylated MGMT supratentorial high-grade glioma (anaplastic
 astrocytoma, anaplastic oligodendroglioma, anaplastic mixed astro oligodendroglioma or
 glioblastoma).

 Arm 2:

 -  Patients must have supratentorial methylated MGMT high-grade glioma (anaplastic
 astrocytoma, anaplastic oligodendroglioma, anaplastic mixed astro oligodendroglioma or
 glioblastoma).

 Both:

 -  Patients must have MRI or CT with contrast within 28 days prior to starting treatment.

 -  Patients must have a Karnofsky performance status ≥ 70% (i.e. the patient must be able
 to care for himself/herself with occasional help from others).

 -  Patients must have adequate blood, kidney and liver function

 -  Patients must be able to provide written informed consent.

 -  Patients and their sexual partners must agree to avoid conception while on the study
 due to possible risks from experimental drugs. Women will need a negative pregnancy
 test to be on the study

 -  Patients may not have any other cancers except skin cancer and localized bladder,
 prostate, cervical, or breast cancer which were cured more than 3 years ago

 Exclusion Criteria:

 -  Patients with other serious diseases

 -  Pregnant women

 -  Patients getting other cancer treatments

 -  Patients with other cancers except for localized skin cancer and localized bladder,
 prostate, cervical, or breast cancer which were cured more than 3 years ago

 -  Patients who have had repeat craniotomy for tumor therapy after receiving radiation
 therapy and temozolomide treatment.

 -  Patients who have previously received other treatments for their cancers

 -  Patient has previously taken ruxolitinib or is allergic to components of the study
 drug

 -  Use of blood thinners

 -  Human immunodeficiency virus (HIV) infection

 -  Active hepatitis B or C infection

 -  Heart diseases including abnormal electrocardiogram (EKG)

 -  Patients unwilling or unable to follow this protocol