Study on BI 54903 (Inhaled Corticosteroid) Administered Twice Daily Via Respimat Inhaler in Patients With Asthma Inadequately Controlled on Low Dose Inhaled Corticosteroid (ICS)
Study on BI 54903 (Inhaled Corticosteroid) Administered Twice Daily Via Respimat Inhaler in Patients With Asthma Inadequately Controlled on Low Dose Inhaled Corticosteroid (ICS)
The aim of the study is to assess and compare efficacy and safety of BI 54903 at 3 doses
 twice daily (b.i.d.), fluticasone propionate hydrofluoroalkane metered dose inhaler (HFA MDI)
 at a dose of 220 mcg b.i.d. and placebo b.i.d. over an 8-week treatment period in asthmatic
 patients aged 12 to 65 years inadequately controlled on low dose Inhaled corticosteroid (ICS)
 as demonstrated by a decrease in forced expiratory volume in one second (FEV1 (range 10-25%)
 and an asthma control questionnaire (ACQ-6) greater or equal 1.5 at time of randomisation
Inclusion criteria:

 1. Must be willing and able to give informed consent

 2. Male and female patients aged at least 12 to 65 years

 3. All patients must have a history of asthma diagnosed by a physician for at least three
 months at the time of enrolment into the trial according to the 2009 Global Initiative
 for Asthma (GINA) Guidelines. The initial diagnosis of asthma must have been made
 before the age of 40 years

 4. All patients must be on a maintenance treatment with either medium-dose inhaled
 corticosteroid (ICS) plus long acting beta agonist (LABA) or high-dose inhaled
 corticosteroid (ICS) without long acting beta agonist (LABA), stable for at least six
 weeks prior to Visit 1

 5. All patients must have a pre-bronchodilator forced expiratory volume in one second
 (FEV1) of not less than 60 to 90% of predicted normal and an asthma control
 questionnaire (ACQ-6) mean score of less than 1.5 at the pre-screening Visit 1

 6. All patients must have an improvement in FEV1 not less than 12 % above baseline and an
 absolute change of at least 200 mL within 15-30 min after administration of 400 mcg
 salbutamol/albuterol hydrofluoroalkane metered dose inhaler (HFA MDI)

 7. Patients must be never-smokers or ex-smokers with a smoking history of less than 10
 pack-years and smoking cessation at least one year prior to screening

 8. Patients must be able to use Respimat® inhaler and metered dose inhaler (MDI)
 correctly

 9. Patients must be able to perform all trial-related procedures including technically
 acceptable pulmonary function tests and electronic peak expiratory flow (PEF)
 measurements, and must be able to maintain records during the study period as required
 in the protocol

 10. To enter treatment period following additional criteria have to be met (at
 randomisation visit):

 -  During the run-in period (at the same clinic visit) all patients must be both
 symptomatic (ACQ-6 mean score equal to or greater than 1.5) and have shown a
 decrease in morning pre-bronchodilator FEV1 not less than 10% and less than or
 equal to 25% from pre-screening baseline FEV1 at Visit 2.

 Exclusion criteria:

 1. Patients with significant pulmonary disease other than asthma or other significant
 medical conditions (as determined by medical history, examination and clinical
 investigations at screening)

 2. Patients with a clinically relevant, abnormal screening haematology and/or blood
 chemistry finding

 3. Patients with a history of upper or lower respiratory tract infection in the past four
 weeks prior to the pre-screening Visit 1, and during pre-screening and run-in periods

 4. Patients with any exacerbation of their underlying asthma during the eight weeks prior
 to the pre-screening Visit 1

 5. Patients with active allergic rhinitis requiring treatment with systemic
 corticosteroids

 6. Any of the following criteria are met during the pre-screening / run-in period (Visits
 1 - 6):

 -  in clinic pre-bronchodilator forced expiratory volume in one second (FEV1 %)
 predicted less than 40%,

 -  more than 12 puffs rescue salbutamol/albuterol hydrofluoroalkane metered dose
 inhaler (HFA MDI) per day for > 2 consecutive days,

 -  exacerbation of asthma.

 7. Patients with a history of pneumonectomy or who are planning to undergo thoracotomy
 for any reason

 8. Patients who are currently in a pulmonary rehabilitation program or have completed a
 pulmonary rehabilitation program in the six weeks prior to the first screening visit 1

 9. Patients with two or more hospitalizations for asthma within the previous twelve
 months

 10. Patients with a recent history of myocardial infarction during the last twelve months
 or known coronary heart disease that requires treatment

 11. Patients with a history of hospitalisation due to heart failure in the past twelve
 months

 12. Patients with myocarditis or any unstable or life-threatening cardiac arrhythmia or
 cardiac arrhythmia requiring intervention or a change in drug therapy within the past
 year

 13. Patients with significant alcohol or drug abuse in the opinion of the investigator
 within the past two years

 14. Patients with rheumatoid arthritis or other systemic diseases that require immune
 system modulating treatment

 15. Patients suffering from narrow angle glaucoma with a history of glaucoma, increased
 intraocular pressure, and/or cataracts

 16. Pregnant or nursing women

 17. Women of childbearing potential not using a highly effective method of birth control.

 18. Patients who have been treated with anti-Immunoglobin-E-antibodies (e.g. omalizumab,
 Xolair®) or other immune system modulating antibodies such as tumor necrosis
 factor-alpha blockers within six months prior to Visit 1

 19. Patients who have been treated with the following drugs during the past four weeks
 prior to Visit 1 or are foreseen to need this during the study:

 -  Non-selective beta-blockers (topical cardio-selective beta-blocker eye
 medications for non-narrow angle glaucoma are allowed),

 -  Oral or other systemic corticosteroids,

 -  Oral beta-agonists,

 -  Changes in allergen desensitisation therapy in last 6 months,

 -  Immune system modulating agents such as methotrexate or cyclosporine,

 -  Inhibitors of cytochrome P450 3A4 such as antifungals (e.g. ketoconazole,
 itraconazole), antibiotics (e.g. erythromycin) or antiretroviral drugs.

 -  Patients who have been treated with leukotriene modifiers, chromones or
 theophylline within two weeks prior to Visit 1

 -  Patients who have been treated with tiotropium within 3 weeks prior to Visit 1