Study in HCV-Infected Patients to Determine the Safety, Tolerability, Pharmacokinetics and Antiviral Activity of JNJ-47910382
Study in HCV-Infected Patients to Determine the Safety, Tolerability, Pharmacokinetics and Antiviral Activity of JNJ-47910382
The purpose of this study is to determine the safety, tolerability, pharmacokinetics (what
 the body does to the medication) and antiviral activity of JNJ-47910382 when administered in
 different dosing regimens in Caucasian genotype-1 chronic HCV-infected patients.
This is a Phase Ib, double-blind (neither physician nor patient knows the treatment that the
 patient receives), randomized (the study drug is assigned by chance), placebo-controlled
 study in treatment-naïve (someone who has never used drugs for HCV infection), Caucasian
 genotype 1 chronic HCV-infected patients. The study consists of a screening period, a 9-day
 treatment period (with 5 days of actual medication intake) and a 4-week follow-up period. The
 patients will be divided over 4 panels of 10 patients each that will be initiated
 sequentially. In each panel patients will receive JNJ-47910382 or placebo during 5
 consecutive days. JNJ-47910382 or placebo will be administered once daily or twice daily.
 Within each panel, 5 patients of genotype-1a and 5 patients of genotype-1b will be enrolled.
 Patients will be randomly assigned to receive active treatment or placebo in such a way that
 4 patients of each genotype receive active treatment and 1 subject of each genotype receives
 placebo. The pharmacokinetic profile of JNJ-47910382 will be assessed in each panel. HCV RNA
 kinetics (HCV RNA level) and HCV resistance will be studied and biomarkers at the messenger
 RNA (mRNA), protein and cell level will be explored. The entire study duration for each
 participant will be approximately four weeks.
Inclusion Criteria:

 -  Chronic (diagnosis of hepatitis C more than or 6 months before the screening period)
 HCV infection. Geno- and subtype should be determined or confirmed at screening, and
 should be 1a or 1b

 -  Never received (Peg) IFN, RBV or any other approved or investigational antiviral
 treatment for chronic HCV infection

 -  HCV RNA level of >100,000 IU/mL at screening (as assessed by standard quantitative in
 vitro nucleic acid amplification assay)

 -  Patients having good accessible veins

 Exclusion Criteria:

 -  Evidence of liver cirrhosis or decompensated liver disease

 -  Patient coinfected with HIV-1 or HIV-2, or hepatitis A or B virus infection, or active
 tuberculosis at study screening

 -  Patient infected/coinfected with non-genotype-1 HCV at study screening

 -  Patient with any cardiac disease at screening, or any active clinically significant
 disease, or medical history or physical examination findings during screening

 -  Patient having uncontrolled/unstable disease such as diabetes, epilepsy, a manifest
 psychiatric disease, thyroid disease or disorders