Correlation Between Different Levels of Thyroid Peroxidase Antibody and Postpartum Thyroiditis in Early Pregnancy
Correlation Between Different Levels of Thyroid Peroxidase Antibody and Postpartum Thyroiditis in Early Pregnancy
At present, attention to thyroid disease during pregnancy is increasing at home and abroad,
 but there is relatively little concern about postpartum thyroid disease, especially high
 incidence of postpartum thyroiditis (PPT). This observational study is to investigate the
 relationship between different levels of thyroid peroxidase antibody (TPOAb) and postpartum
 thyroiditis (PPT) in early pregnancy (1-12 weeks of pregnancy), and to explore whether PPT
 can be predicted by different TPOAb levels. According to the TPOAb level in early pregnancy,
 the postpartum of pregnant women was followed up, PPT was detected early, and intervention
 was performed according to thyroid dysfunction.
First pregnant women who between the ages of 18 to 35 years old and normal thyroid function
 before pregnancy were selected. Recruit 300 pregnant women who early pregnancy (1-12 weeks of
 pregnancy) screening TPOAb positive and normal Free triiodothyronine (FT3), normal free
 thyroxine (FT4) ,Thyroid Stimulating Hormone (TSH) <4.78mIU / L as the observation group.
 They will be divided into low-level group (TPOAb at 34-102 IU/ml), medium-level group (TPOAb
 at 103-204 IU/ml), and high-level group (TPOAb>205) according to TPOAb. Recruit 100 pregnant
 women who early pregnancy (1-12 weeks of pregnancy) screening TPOAb negative and normal FT3,
 normal FT4,TSH <4.78mIU / L as the Control group.

 Thyroid function (FT3, FT4, TSH) and TPOAb, thyroglobulin antibody(TgAb) ,thyroid hormone
 receptor antibody(TRAb) will be screened in the observation group and the control group at 3
 months, 6 months, and 12 months after delivery. If the mother is diagnosed with postpartum
 thyroiditis (PPT), continue to screen for thyroid function (FT3, FT4, TSH) and thyroid
 antibodies (TPOAb, TRAb, TgAb) 18 months after delivery. The correlation between the early
 pregnancy TPOAb level and postpartum thyroiditis was analyzed between the observation group
 and the control group and the observation group. It was explored whether the occurrence of
 postpartum thyroiditis (PPT) can be predicted according to the TPOAb level in the first
 trimester. And targeted maternal effective follow-up and timely intervention to treat PPT
 provide important basis.
Inclusion Criteria:

 1. Observation group:

 -  Pre-pregnancy tests for normal thyroid function (FT3, FT4, TSH)

 -  First pregnancy between the ages of 18 to 35 years old

 -  Early screening (1-12 weeks of pregnancy) initial screening TPOAb
 positive，thyroid function FT3, FT4 normal, TSH<4.78mIU/ L

 2. Control group:

 -  Pre-pregnancy tests for normal thyroid function (FT3, FT4, TSH) and antibodies

 -  First pregnancy between the ages of 18 to 35 years old

 -  Early pregnancy (1-12 weeks of pregnancy) initial screening negative
 thyroid-related antibody and thyroid function FT3, FT4 normal, TSH< 4.78 mIU/L.

 Exclusion Criteria:

 -  Combined with other autoimmune diseases (such as systemic lupus erythematosus, etc.)

 -  Type 1 diabetes

 -  Gestational diabetes;

 -  Primary screening TRAb positive;

 -  Previous patients with Graves, subacute thyroiditis,chronic hepatitis

 -  Artificial pregnancy

 -  Suffering from liver and kidney dysfunction and other major diseases

 -  Have a history of adverse pregnancy

 -  Pregnant women with premature birth, miscarriage, intrauterine dysplasia and other
 unhealthy pregnancies withdrew from observation.