Temporal Relationship Between Motor Fluctuations and Nonmotor Fluctuations
Temporal Relationship Between Motor Fluctuations and Nonmotor Fluctuations
The purpose of this study is to determine the temporal relationship between motor
 fluctuations and non-motor fluctuations in persons with Parkinson's disease.

 Observational study case-only
Objectives

 1. how many patients will experience motor or nonmotor fluctuation during follow-up period?

 2. in how many patients, does motor fluctuation precede nonmotor fluctuation?

 3. in how many patients, does nonmotor fluctuation precede motor fluctuation?

 Participants: persons with Parkinson disease in early stage who does not have motor or
 nonmotor fluctuation

 Recruitment period: 3 years from the commencement of the study Follow-up period: 3 years for
 each participants
Inclusion Criteria:

 -  clinical diagnosis of Parkinson disease by United Kingdom Parkinson's Disease Society
 Brain Bank criteria

 -  early stage

 Exclusion Criteria:

 -  dementia (MMSE<26)

 -  persons who refuse participating