A Randomized Double Blind Placebo Control Study of Huang-Chi-Wu-Wu- Tang in Patients With Intracranial Arterial Stenosis
A Randomized Double Blind Placebo Control Study of Huang-Chi-Wu-Wu- Tang in Patients With Intracranial Arterial Stenosis
Intracranial arterial prominent stenosis (IAPS) is one of main cause of stroke especially in
 Asia. Although antiplatelet aggregative or anticoagulant agent and even surgical operation
 are used to treat patients with IAPS, the incidence of stroke occurrence still remains high.
 In addition, symptomatic IAPS most common cause continuous deterioration, thus, increase the
 incidence of stroke. Therefore, there is a good method to reduce the inceidence of stroke
 that is to prevent the progressive deterioration of IAPS.

 Huang-Chi-Wu-Wu-Tang is made of Astrgalus membranaceus (Fisch.) Gge , Paeonia lactiflora Pall
 , Cinnamom Twig , Zingiber officinale Rose , Ziziphus jujube Mill , and can treat hemiplegia
 in the traditional Chinese medicine writings. Astragaloside IV is a component of Astrgalus
 membranaceus, may reduce th cerebral infarction area in middle cerebral arterial occlusion
 mice. The investigators previous studies have known that paeoniflorin that a component of
 Paeonia lactiflora Pall can decrease the cerebral infarction area and neurological deficit in
 middle cerebral arterial occlusion rats. Therefore, the purpose of the present study was to
 investigate the effect of Huang-Chi-Wu-Wu-Tang on patients with IAPS.
Inclusion Criteria:

 1. Had received Transcranial Doppolar Sonography.

 2. Age >40 years old.

 3. Gender: Male or female.

 4. The subject or their legal representative gave written informed consent to
 participate.

 5. Meet with one of the two Transcranial Doppolar Sonography results below:

 -  The evaluated standard of MCA M1 stenosis of 50-99% are as follows:

 -  PSV >140 cm/s

 -  MFV >100 cm/s

 -  The evaluated standard of BA stenosis of 50-99% are as follows:

 -  PSV >100 cm/s

 -  MFV >60 cm/s

 Exclusion Criteria:

 1. Refused to sign the Informed Consent Form.

 2. Too irritable to accept the evaluation.

 3. Age ≦40 years old.

 4. Major diseases such as Myocardial Infarction、Heart failure、Chronic pulmonary
 obstructive disease(COPD）with dyspnea、Liver failure or Renal failure.

 5. Pregnancy or breast-feeding.