A Comparison of Effectiveness of Oral Sucrolfate, Alginate and Hydrotalcide in Dispeptic Pain Treatment
A Comparison of Effectiveness of Oral Sucrolfate, Alginate and Hydrotalcide in Dispeptic Pain Treatment
Dyspepsia is a very common but non-specific complaint that may indicate a group of symptoms
 that can be attributed to the upper gastrointestinal system, such as epigastric discomfort,
 abdominal bloating or fullness, stomach upset and nausea or vomiting that may be associated
 with food.

 This study aimed to improve treatment management of patients with complaints of dyspeptic
 pain and emergency services, and to compare treatment efficacy of oral sucralfate, alginate
 and hydrotalcite, which are widely used in our country. Literature According to our research,
 our study is the first study to compare different antacids in our study of emergency serviste
 dyspepsia.
This study was performed prospectively, randomly, controlled, double-blind to compare the
 efficacy of oral sucralfate, alginate and hydrotalcite in patients presenting with emergency
 department dyspeptic complaints at Pamukkale University Medical Faculty Hospital Emergency
 Medicine Department.

 Patients who were referred to the emergency department with stomach ache or dyspeptic
 complaints were taken to the study. Treatment medicines were applied according to the
 randomization scheme of the study patients.

 This study was carried out in Pamukkale University Faculty of Medicine Emergency Medicine
 Department during 8 months between 01.03.2016 and 30.10.2016. Approximately 98,000 adult
 patients / year in the emergency department have a research assistant and / or faculty member
 who will check the research as a 24-hour primer. This study included 300 cases between 18 and
 60 years of age who were admitted to our emergency department with dispeptic complaints,
 agreed to participate in the study, informed consent, and met inclusion criteria. The
 criteria for receiving and not receiving work were specified at the beginning of the study.

 When appropriate patients were admitted to the study, the patient was taken to the emergency
 monitoring monitor and monitored once the written consent was obtained. Patients were
 assigned to one of the study groups according to the study number, according to the
 randomization scheme prepared by a non-emergency service computer. The numbers for the
 previously numbered workgroups were kept in unmarked envelopes and the envelope was opened by
 the study nurse to prepare the study medicine. The study medicines were prepared by an
 independent person who did not participate in the study or by the responsible work nurse who
 was at the helpline and was given to the patient by the other nurse. For each group, the
 drugs prepared in a 10 cc syringe were wrapped around the syringe with a color patch that did
 not show any similarity. When the medication was given to the patient, the patient's nose was
 closed and the drug smell was not taken. Patients were observed for 30 minutes in the
 emergency department and 30-minute VAS (Visual Analog Scale) score 5 and above were given to
 the patient for rescue treatment.

 The information and data of the patients were collected by questionnaire. In the first part
 of the questionnaire, patients' demographic information address, telephone numbers, medical
 backgrounds, medications and vital findings were recorded. Detailed physical examinations of
 all patients were evaluated by emergency physician. Patients diagnosed with dyspepsia other
 than dyspepsia such as acute coronary syndrome, pancreatitis, cholecystitis, acute abdomen,
 ileus, malignancy and gastroenteritis were excluded as a result of history and physical
 examination. Patients who did not give their consent to participate were also excluded from
 the study. The patient with unexplained dyspepsia was directed to the gastroenterology
 polyclinic for endoscopy with necessary information. After discharge, patients were asked
 whether they had recurring epigastric pain within 24 hours.
Inclusion Criteria:

 -  Stomach pain, swelling or dispeptic complaints.

 -  Men and women between the ages of 18-60.

 -  Patients with VAS> 5.

 Exclusion Criteria:

 -  Pregnancy and lactation.

 -  Sucralfate, alginate, hydrotalcite allergy.

 -  Emergency service arrives with acute psychiatric symptoms.

 -  Gastrointestinal system bleedings.

 -  Chronic renal failure, liver cirrhosis, structural and functional heart disease.

 -  Gastric malignancy and terminal illness.

 -  Patients suspected of having a different problem such as ileus, biliary colic,

 -  pancreatitis, hepatitis.

 -  Patients who refuse to participate in the study.

 -  Those who can not use VAS.

 -  Presence of ischemic findings on the arrival ECG.