Safety and Tolerability of Cidofovir Gel Applied on Cervix Squamous Lesions
Safety and Tolerability of Cidofovir Gel Applied on Cervix Squamous Lesions
Human Papilloma Virus (HPV) infections induce cervical intraepithelial neoplasia (CIN) of
 cervix. To reduce incidence of invasive tumor associated with high grade CIN lesions, the
 standard treatment is the conisation of cervix (surgical act). A local treatment with the
 antiviral and anti-proliferative cidofovir would preserve the cervix of young subjects and
 reduce obstetrical morbidity induced by the conisation.

 This clinical study is aimed at :

 1. evaluating the tolerance and safety of a cidofovir gel directly applied on the cervix
 exhibiting high grade CIN lesions;

 2. evaluating the pharmacokinetic (PK) profile of cidofovir after local application.
Inclusion Criteria:

 -  women aged between 18 and 50 years old

 -  volunteers

 -  informed consent signed

 -  cervical lesion classified CIN 2 or 3, on a biopsy made during the 6 preceding weeks

 -  no sexual activity or use of effective mechanical, hormonal or intrauterine
 contraception (except hormonal vaginal ring)

 Exclusion Criteria:

 -  pregnancy or breast feeding

 -  subtotal hysterectomy

 -  current or ancient renal impairment

 -  current immune disorder

 -  current use of drugs interfering with renal function

 -  current treatment for any cancer

 -  current use of treatment interfering with immunity

 -  current use of anti-viral treatment

 -  current or recent participation to another experimental study during the last 3 months
 before the screening visit

 -  current vaginal application of drugs or cosmetics

 -  local or general condition incompatible with the experimental treatment in the opinion
 of the principal investigator