The Preventive Infection Role of One Week Antibiotics Before Minimally Invasive Upper Tract Lithotomy
The Preventive Infection Role of One Week Antibiotics Before Minimally Invasive Upper Tract Lithotomy
Minimally invasive upper tract lithotomy is currently a common operation method on treatment
 of urinary tract stones, but the postoperative complication urinary tract infection or
 urinary sepsis has turned into a serious threat to the patient's life, when severe, can
 result in a higher death rate.Although more the more importance were attached to, an
 effective prevention measures still have not been found.

 Among Urinary calculi, the higher rates of infection stone resulted in a higher incidence of
 postoperative urinary tract infection. The conventional postoperative prophylaxis medicine
 was the use of antimicrobial drugs half an hour before surgery.Foreign studies had shown that
 continuous preoperative one week use of nitrofurantoin can significantly reduce the incidence
 of urinary sepsis. So the investigators assume that preoperative extended use time of
 prophylaxis antibiotic may reduce the incidence of urinary tract infection or urinary sepsis.

 This study uses a computerized random method. According to preoperative use of different
 antimicrobial drug or treatment, all patients are randomly divided into five groups, namely
 levofloxacin 3days group,levofloxacin 7days group, nitrofurantoin 3days group,nitrofurantoin
 7days group and cefuroxime group.The levofloxacin group receives levofloxacin 0.5g, qd, po,
 the nitrofurantoin group was given oral nitrofurantoin 100mg, tid, po.to explore the better
 antibiotics types, medication timing and duration of treatment to prevent postoperative
 infection after minimally invasive upper tract lithotomy, so as to reduce the incidence of
 postoperative urinary tract infection or sepsis.
1. Sample Calculation: Based on the literature, the occurrence rate of fever after
 Percutaneous Nephrolithotripsy (PCNL) was 21% -39.8%, urinary tract infection rate 38%,
 SIRS rate 11.2%, the incidence rate of urinary sepsis 0.3% - 4.7%,and the mortality rate
 with sepsis was 60% -80%. Expected incidence rate of urinary tract infection decreased
 to 23%, and the difference is statistically significant. Provided that the case of the
 two groups is equal, the expected strength of evidence is 0.9, α = 0.05, the lost up to
 20%, the investigators calculated that the minimum sample size required is 150 cases.
 Urology department has 70 ward beds with PCNL surgery or Flexible Ureteroscopy
 Lithotripsy (FURL) about 400 cases per year, and the sample size can meet the study
 requirements. All cases are from outpatient or emergency department.

 2. Grouping and medication: This study uses a computerized random method. According to
 preoperative use of different antimicrobial drug or treatment, all patients are randomly
 divided into five groups, namely levofloxacin 3days group,levofloxacin 7days group,
 nitrofurantoin 3days group,nitrofurantoin 7days group and cefuroxime group.and each
 group of levofloxacin group or nitrofurantoin group has been given prophylactic for 3 or
 7 days. The levofloxacin group receives levofloxacin 0.5g, qd, po, the nitrofurantoin
 group was given oral nitrofurantoin 100mg, tid, po. All patients in cefuroxime group, 30
 minutes before surgery, are given preventive medication cefuroxime 1.5g ivgtt, and
 continue using 1.5g q12h ivgtt until postoperative 48 hours.

 3. Sterilization or bacterial culture: Surgical areas is disinfected with 10%
 povidone-iodine, all surgical instruments are sterilized by high-temperature steam.
 after renal pelvises are punctured, some urine is extracted for bacterial culture.
 Stones removed by surgery are fragmented into small fragments, and stored at 36.5 ℃
 tubes within a day in order to facilitate the proliferation of bacteria, then grown in
 culture medium for bacterial culture.

 4. Preoperative items observed: urinalysis, urine culture, renal function, blood, CRP,
 procalcitonin, bacterial endotoxin test, kidney function, body temperature changes
 prophylactic or preoperative. Imaging tests include urinary tract calculi line
 pyelography and CT.

 5. Postoperative follow-up: urine, urine culture, renal function, blood routine, CRP,
 procalcitonin, bacterial endotoxin test, renal function and urinary tract stones line
 urography and CT examination were made in all patients. Vital signs such as body
 temperature, heart rate and blood pressure once every two hours were monitored in 48
 hours, and were monitored every 4 hours after 48 hours. Blood routine was checked daily
 until 3 days postoperative or 48 hours after abatement of fever. When white blood cell
 count> 12 × 109 / L and / or body temperature> 38 ℃ °, it is considered to be systemic
 inflammatory response (SIRS, modified Sepsis Diagnostic Criteria). Renal fistula was
 retained for 48 hours Postoperative, and pleural effusion fistula was removed if there
 was no fever after it was pinched 24 hours.

 6. Statistical analysis: Statistical Product and Service Solutions (SPSS)19.0 statistical
 software was used for analysis. Count data were analyzed by analysis of variance or t
 Test. Measurement data were analyzed by Chi-square Test. The results were evaluated
 within the safe range of 95%,when P <0.05,it was statistically significant.
Inclusion Criteria:

 -  Clinical diagnosis of urinary tract lithiasis (stones ≥ 2cm) or urolithiasis with
 hydronephrosis

 Exclusion Criteria:

 -  antimicrobial drugs been administered in the latest month

 -  immunosuppressor been administered in the latest month

 -  urinary tract infection or positive urine culture results

 -  history of urinary calculi surgery

 -  diabetes

 -  chronic renal failure patients

 -  neurogenic bladder dysfunction

 -  abnormal anatomy of the kidney

 -  neuromuscular dysfunction (spina bifida, paraplegia, green Barry syndrome, or
 quadriplegia)

 -  more than 90 minutes operation time

 -  more than 1000 ml blood loss