Vitamine D3 Supplementation in Patients With Serum Values +/- 20ng/ml
Vitamine D3 Supplementation in Patients With Serum Values +/- 20ng/ml
A comparative randomized study that will evaluate the effect of a monthly supplementation
 with 52000 units of Vitamine D3 vs hygienic-dietary measures in the development of
 respiratory infections such as COVID-19, H1N1, A, B Influenza during 6 months of follow-up in
 patients with serum vitamin D values +/- 20ng/ml.
A comparative randomized clinical trial that will evaluate the effect of 2 treatments in
 health personnel of Hospital Clínica Nova with serum vitamin D values +/- 20ng / ml.

 1. Supplementation with 52,000 units of vitamin D3 monthly

 2. Hygienic-dietary measures: sun exposure 10 minutes a day plus recommendation of
 consumption of foods rich in vitamin D.

 Hypothesis: There will be no difference in the development of respiratory infections
 (COVID-19, H1N1 Influenza, A, B influenza) in health personnel with serum levels of vitamin D
 equal or greater than 20ng / ml when they receive supplementation vs treatment based on
 hygienic-dietary measures (diet and sun exposure), in a 6-month follow-up.

 Baseline serum levels will be assessed, and monthly follow-up will be given regarding the
 development of symptoms suggestive of respiratory tract infection. The monitoring of serum
 levels of vitamin D will be every 3 months.

 Efficacy endpoint: The most effective treatment will develop a lower respiratory tract
 infection rate ( COVID-19 and/or H1N1, A or B Influenza ) during the follow-up period.

 The sample size will be of a finite population as it will include all health personnel who
 work at Hospital Clínica Nova.

 Procedures:

 1. Serum levels of vitamin D (25-hydroxyvitamin D) will be measured in all medical
 personnel working at Hospital Clínica Nova.

 2. Vitamin D3 will be supplemented to all health personnel with serum levels of vitamin D
 +/-20ng / ml

 3. Treatment group will be randomized to patients with vitamin D3 levels+/- 20ngml.

 4. Serum vitamin D levels will be monitored every 3 months

 5. Monthly follow-up will be given through the endocrinology consultation of the
 development of respiratory symptoms
Inclusion Criteria:

 -  Age 18-90 years

 -  Both genders

 -  Absence of infection by COVID-19, influenza H1N1, influenza A or B at the time of
 measurement of serum vitamin D levels.

 -  Absence of infection at any site of bacterial, fungal or other origins

 -  Health worker at Hospital Clínica Nova.

 Patient Exclusion Criteria for both arms:

 -  Serum Vitamin D levels> 100ng / ml

 -  Previous consumption of supplements containing Vitamin D3

 -  Pregnancy