FH Detection in Children by Salivary Test
FH Detection in Children by Salivary Test
Familial Hypercholesterolemia is a common cause of premature coronary heart disease, it is
 present in 1 per 500 to 1 per 250 people of the general population. Studies on families of
 Hypercholesterolemia have shown that children with Hypercholesterolemia have a major increase
 in risk of coronary heart disease after the age of 20. The difference between
 Hypercholesterolemia and normal children in their atherogenic profil begin at the age of
 Nowadays , systematic screening techniques are not well implemented whereas their are clear
 World health organization guidelines.

 International studies show treatment must be initiated early as at the age of eight years
 old.

 In pediatry, Parents can be reluctant to practice blood test on their children. In order to
 allow more patients to be diagnosed and treated early enough to prevent major complications
 we need to find an non invasive test.

 The main objective is to define the level of detection of cholesterol in saliva with two
 enzymatic tests. Furthermore we aim to evaluate the performance of salivary detection of
 cholesterol in children.
Inclusion Criteria :

 -  children under 18 years old, with familial hypercholesterolemia

 -  children under 18 years old, intending surgery

 -  being able to spit

 Exclusion Criteria:

 -  poor dental health

 -  for control patients: to have a known cholesterol disease