Accelerated Hypofractionated Radiotherapy (AHF-RT) for the Treatment of Breast Cancer
Accelerated Hypofractionated Radiotherapy (AHF-RT) for the Treatment of Breast Cancer
The goal of this study is to explore the safety, effectiveness, quality of life, and cost
 effectiveness of accelerated hypofractionated radiotherapy (AHF-RT) as treatment after
 lumpectomy in patients with early stage breast cancer.
The traditional radiation treatment schedule for patients who have had a lumpectomy for early
 stage breast cancer is 15 to 30 treatments delivered once a day for 3 to 6 weeks. This
 treatment schedule can be inconvenient and costly for elderly, rural, uninsured, and minority
 patients. This study will evaluate a new radiation treatment schedule called whole-breast
 accelerated hypofractionated radiotherapy (AHF-RT). AHF-RT delivers higher doses of radiation
 in fewer treatments than traditional radiation therapy. The AHF-RT treatment course is
 completed with 5 radiation treatments delivered once a week for 5 weeks.

 The purpose of this study is to determine if accelerated hypofractionated radiotherapy
 (AHF-RT) is a safe, effective, more convenient, and less costly alternative to traditional
 radiation that will offer the same chance of cure with no additional side effects.
Inclusion Criteria:

 Only women who satisfy all of the following conditions will be eligible for this study.

 1. must consent to be in the study and must have signed an approved consent form
 conforming with federal and institutional guidelines

 2. must be at least 21 years old

 3. must have stage 0, I, or II breast cancer

 4. On histological examination, the tumor must be ductal carcinoma in situ (DCIS) or
 invasive adenocarcinoma of the breast.

 5. Surgical treatment of the breast must have been breast conserving surgery (BCS). The
 margins of the resected specimen must be histologically free of tumor (including DCIS
 component). Reexcision of surgical margins is permitted.

 6. Gross disease may be unifocal or multifocal with pathologic (invasive and/or DCIS)
 tumor size excised with negative margins.

 7. Patients with invasive breast cancer are required to have axillary staging which can
 include sentinel node biopsy alone (if sentinel node is negative), sentinel node
 biopsy followed by axillary dissection or sampling with a minimum total of 6 axillary
 nodes (if sentinel node is positive), or axillary dissection alone (with a minimum of
 6 axillary nodes). Axillary staging is not required for patients with DCIS.

 8. must begin adjuvant therapy (chemotherapy or radiotherapy) within 9 weeks following
 the last surgery for breast cancer (lumpectomy, re-excision of margins, or axillary
 staging procedure)

 9. Patients must have all usual and customary hormone receptor (ER/PR) and estrogen
 receptor (ER) analysis performed on the primary tumor prior to enrollment. Patients
 with invasive disease must have HER2 receptor status determined (positive or negative)
 with immuno-histochemistry (IHC) and/or fluorescent in-situ hybridization (FISH).

 10. At the time of study enrollment, patients must have had a history & physical exam
 within 4 months and a bilateral mammogram within 6 months.

 11. Patients with a history of non-breast malignancies are eligible if they have been
 disease-free for 5 or more years prior to enrollment and are deemed by their physician
 to be at low risk for recurrence. Patients with the following cancers are eligible if
 diagnosed and treated within the past 5 years: carcinoma in situ of the cervix,
 carcinoma in situ of the colon, melanoma in situ, and basal cell and squamous cell
 carcinoma of the skin.

 12. Patients must live in a county that is designated as Appalachian and/or rural by
 Kentucky Cancer Registry Criteria (see list below) and/or must hold their primary
 residence at least 10 miles from the nearest radiation facility. Patients who do not
 fit these criteria may still be considered eligible if they are determined to suffer
 significant financial and/or transportation hardship during a typical course of CF-RT
 or HF-RT (in the judgment of any of their treating physicians). Patients who live
 outside the Commonwealth of Kentucky are eligible if they fit any of these
 aforementioned conditions.

 -  Appalachian counties in KY include: Adair, Bath, Bell, Boyd, Breathitt, Carter,
 Casey, Clark, Clay, Clinton, Cumberland, Edmonson, Elliott, Estill, Fleming,
 Floyd, Garrard, Green, Greenup, Harlan, Hart, Jackson, Johnson, Knott, Knox,
 Laurel, Lawrence, Lee, Leslie, Letcher, Lewis, Lincoln, Madison, Magoffin,
 Martin, McCreary, Menifee, Metcalfe, Monroe, Montgomery, Morgan, Nicholas,
 Owsley, Perry, Pike, Powell, Pulaski, Robertson, Rockcastle, Rowan, Russell,
 Wayne, Whitley, Wolfe.

 Exclusion Criteria:

 Men are not eligible for this study. Women with one or more of the following conditions are
 ineligible for this study.

 1. T3, stage III, or stage IV breast cancer

 2. More than 3 histologically positive axillary nodes

 3. Axillary nodes with definite evidence of microscopic or macroscopic extracapsular
 extension

 4. One or more positive non-axillary sentinel node(s) (Note that intramammary nodes are
 staged as axillary nodes.)

 5. Palpable or radiographically suspicious ipsilateral or contralateral axillary,
 supraclavicular, infraclavicular, or internal mammary nodes, unless there is
 histologic confirmation that these nodes are negative for tumor

 6. Suspicious microcalcifications, densities, or palpable abnormalities (in the
 ipsilateral or contralateral breast) unless biopsied and found to be benign

 7. Non-epithelial breast malignancies such as sarcoma or lymphoma

 8. Proven multicentric carcinoma (invasive cancer or DCIS) in more than one quadrant or
 separated by 4 or more centimeters

 9. Paget's disease of the nipple

 10. Synchronous bilateral invasive or non-invasive breast cancer

 11. History of invasive breast cancer or DCIS (Patients with a history of lobular
 carcinoma in situ (LCIS) treated by surgery alone are eligible.)

 12. Surgical margins that cannot be microscopically assessed or are positive at pathologic
 evaluation (If surgical margins are rendered free of disease by reexcision, the
 patient is eligible.)

 13. Treatment plan that includes regional nodal irradiation

 14. Current therapy with any hormonal agents such as raloxifene (Evista®), tamoxifen, or
 other selective estrogen receptor modulators (SERMs), either for osteoporosis or
 breast cancer prevention (Patients are eligible only if these medications are
 discontinued prior to enrollment.)

 15. Cosmetic breast implants (Patients who have had implants removed are eligible.)

 16. Prior breast or thoracic RT for any condition

 17. Collagen vascular disease, specifically dermatomyositis with a CPK level above normal
 or with an active skin rash, systemic lupus erythematosis, or scleroderma

 18. Pregnancy or lactation at the time of proposed randomization. Women of reproductive
 potential must agree to use an effective non-hormonal method of contraception during
 therapy.

 19. Psychiatric or addictive disorders or other conditions that, in the opinion of the
 investigator, would preclude the patient from meeting the study requirements