Shortened Regimens for Drug-susceptible Pulmonary Tuberculosis
Shortened Regimens for Drug-susceptible Pulmonary Tuberculosis
The purpose of the study is to evaluate the safety and efficacy of two shortened regimens for
 newly diagnosed smear positive drug susceptible pulmonary tuberculosis in comparison to World
 Health Organization recommended standard 6-month regimen.
1. Design: The study is a multi-center, randomized,controlled non-inferiority trial.

 2. Population: patients with newly diagnosed drug-susceptible pulmonary TB who fulfill the
 inclusion and exclusion criteria.

 3. Investigational regimens:

 Experimental group 1 regimen consists of levofloxacin, isoniazid , rifampicin,ethambutol
 and pyrazinamide for 4.5 months.

 Experimental group 2 regimen consists of isoniazid, rifampicin, ethambutol and
 pyrazinamide for 4.5 months.

 The control group is WHO recommended regimen conmposed of isoniazid , rifampicin,
 ethambutol and pyrazinamide for 2 months, followed by isoniazid , rifampicin for 4
 months.

 Dosage: isoniazid 300mg(given once daily), rifampin 450mg(less than 50kg,given once
 daily)or 600mg(more than 50kg,given once daily), pyrazinamide 1500mg(less than
 50kg,given once daily)or 30mg/kg(more than 50kg,once daily), ethambutol 750mg (less than
 50kg,once daily) or 1000mg (more than 50kg,once daily), levofloxacin 600mg(less than
 50kg,given once daily) or 800mg(more than 50kg,once daily)..

 4. Trial objectives: to evaluate that shortened regimens is not inferior to standard
 treatment in terms of efficacy and safety for new smear positive pulmonary TB patients.

 5. Primary and Secondary outcome measures:

 The primary efficacy outcome measures include (a)the percentage of participants with TB
 recurrence/relapse by 24 months after the end of treatment;(b) percentage of
 participants with treatment failure at either 4.5 months or 6 months after
 randomization. (a) Time to sputum smear or culture conversion within intensive phase.(b)
 Sputum smear conversion proportion at the treatment completion. (c) Number of adverse
 drug reaction occurring during treatment or follow-up period. (d) Radiological
 manifestation change of TB lesion or cavity.(e) Patients adherence rate.

 6. Sample Size:

 Approximately 3900 participants will be enrolled and randomized with 1:1:1 ratio into
 either Experimental group1, Experimental group2 or control group.

 7. Blinding:

 The study is an open-label study.

 8. Assessment and follow-up:

 All patients will be followed by to 2 years after completion of treatment.
Inclusion Criteria:

 1. Is willing and able to give informed consent to participate in the trial treatment and
 follow-up (signed or witnessed consent if the patient is illiterate).

 2. Is aged 18-65 years.

 3. Has twice positive acid-fast bacilli(AFB) sputum smear or positive sputum culture
 result, along with chest x-ray imaging consistent with active pulmonary tuberculosis.

 4. Newly diagnosed cases receiving anti-TB treatment for less than one month

 5. Urine Human Chorionic Gonadotropin(U-HCG) negative and must agree to use effective
 contraception during the trial period.

 6. Has Alanine aminotransferase（ALT）and Total bilirubin（TBil） less than 2 times the upper
 limit of normal ; has Creatinine clearance rate （CrCI） more than 30ml/min; has
 Hemoglobin more than 7.0g/dL; has Platelet（PLT）more than 50 x10^9/L before study
 entry.

 Exclusion Criteria:

 1. Concomitant severe cardiovascular, liver, kidney, nervous system, hematopoietic system
 and other diseases, or concomitant neoplastic diseases. Or extensive lesion with
 respiratory insufficiency.

 2. Uncontrolled diabetes mellitus.

 3. Concomitant mental disorders.

 4. Is HIV positive.

 5. Is critically ill, and in the judgment of the investigator, not fit for the study or
 unlikely to complete the full course of study.

 6. Is known to be pregnant or breast-feeding.

 7. Is unable or unwilling to comply with the treatment, assessment, or follow-up
 schedule.

 8. Is taking any medications contraindicated with the medicines in any trial regimen of
 the study.

 9. Has a known allergy to any drug of treatment regimens.

 10. Is currently taking part in another trial.

 11. Has a QTc interval more than 480ms.