IMMUNOPHENOTYPE ROLE IN THE EVALUATION OF CLINICAL RESPONSE
IMMUNOPHENOTYPE ROLE IN THE EVALUATION OF CLINICAL RESPONSE
The study proposed by SSCVD Allogeneic Stem Cells of this Hospital provides for the
 collection of a series composed of patients with multiple myeloma undergoing allogeneic stem
 cell transplants at our center in the period 2000-2011.

 This collection is carried out with retrospective investigation , through the review of paper
 and electronic records and data cards already collected as part of clinical trials conducted
 by our own Division and approved by the Ethics Committee of Management.

 The purpose of data collection is particularly retrospective analysis of the incidence of
 extramedullary relapse , the response in flow cytometry immunophenotypic and clinical
 response of the disease , will also be taken into consideration for overall survival ( OS) ,
 event-free survival (EFS) , the cumulative incidence of treatment-related mortality and
 graft- versus-host disease ( GVHD ), acute and chronic.

 The data were processed in a completely anonymous and as provided by law. The results of the
 study will not result in any diagnostic or therapeutic intervention on patients still alive.
Inclusion Criteria:

 Adult patients with multiple myeloma undergoing allogeneic stem cell transplantation in the
 period 2000-2011 at the University Transplant Center of the Division of Hematology.

 Were taken into account both donor transplants voluntary blood relative.

 Exclusion Criteria:

 Patients who died early after allogeneic transplantation (<3 months) in which has not been
 evaluated disease status.

 In the evaluation of the response of immunophenotypic disease were excluded from the
 analysis of bone marrow aspirate samples with low cellularity.