Effects of Dexmedetomidine on OI, RI and Inflammatory Factors in Patients Undergoing Palatopalatyngoplasty.
Effects of Dexmedetomidine on OI, RI and Inflammatory Factors in Patients Undergoing Palatopalatyngoplasty.
The purpose of this study is to investigate the efficacy of dexmedetomidine on oxygenation
 index, respiratory index and inflammatory factors, and to explore the protective effect of
 the dexmedetomidine on respiratory function in patients undergoing palatopalatyngoplasty.
Obstructive sleep apnea syndrome is common among people, especially among obese people, Which
 is characterized by periodic or complete upper airway obstruction and hypoxia during sleep.
 Intermittent hypoxia contributes to the lung damage by increased oxidative stress,
 inflammation. Some researchers suggested that dexmedetomidine can inhibit inflammatory
 reaction and lessen the damage of respiratory function. The aim of this study is to
 investigate the efficacy of dexmedetomidine on oxygenation index, respiratory index and
 inflammatory factors, and to explore the protective effect of the dexmedetomidine on
 respiratory function in patients undergoing palatopalatyngoplasty.
Inclusion Criteria:

 -  Patients undergoing palatopalatyngoplasty

 -  ASA physical status II-III

 -  Aged 18-65 years

 -  BMI 18.5-30kg/m2

 Exclusion Criteria:

 -  Bradycardia

 -  Atrioventricular block

 -  Allergic to the drugs

 -  Complicating pulmonary disease(including pulmonary infection,COPD, asthma and so on)