Inheritance of Osteosarcoma & Paget's Disease Through Chromosome 18:
Inheritance of Osteosarcoma & Paget's Disease Through Chromosome 18:
Researchers have previously demonstrated loss of heterozygosity in a region on chromosome
 18q, associated with osteogenic sarcomas in bone affected by Paget's disease. The loci used
 in this study are specifically described by those authors as showing loss of heterozygosity
 in 6 of 7 affected families.
As above, no additional information
Inclusion Criteria:

 -  This is a familial study therefore the only inclusion/exclusion criteria would be that
 subjects must be a blood relative and over the age of 18.

 -  The subjects are proband and father along with unaffected blood relatives. Their
 peripheral blood will act as a control and provide information to delineate the
 inheritance from the father, as seen in the son.

 Exclusion Criteria:

 -  Not part of the family