Study of Pituitary Size and Function in Familial Dwarfism of Sindh
Study of Pituitary Size and Function in Familial Dwarfism of Sindh
OBJECTIVES: I. Assess pituitary size and anatomic configuration by magnetic resonance imaging
 (MRI) in 4 affected dwarfs in the province of Sindh, Pakistan.

 II. Evaluate ultradian growth hormone (GH) secretory patterns in 4 affected dwarfs.
PROTOCOL OUTLINE: Pituitary size and anatomy and growth hormone response are evaluated.

 All patients undergo MRI of the pituitary fossa on day 1. On day 2, homozygous patients
 receive a slow infusion of normal saline with blood sampling every 10 minutes.
-  Familial Dwarfism of Sindh

 -  Severe short stature but proportionate without dysmorphic features

 -  Normal body size and weight at birth

 -  Bone age is severely delayed

 -  Puberty is somewhat delayed (age 15-16)

 -  Fertility present in at least 3 dwarfs