Influence of Binge Drinking on Glucose Metabolism in Patients With Type 1 Diabetes - A Pilot Study
Influence of Binge Drinking on Glucose Metabolism in Patients With Type 1 Diabetes - A Pilot Study
Although there is no evidence that individuals with type 1 diabetes have a different approach
 to alcohol compared to the background population, nevertheless, its use does have
 implications for patients mainly because of the risk of hypoglycaemia unawareness. However,
 binge drinking has been implicated as a factor in the development of ketoacidosis and is
 probably under-recognised. The aim of this study is to examine the effect of binge drinking
 on glucose, insulin, counter-regulatory hormones and other metabolites in patients with type
 1 diabetes. It is hoped that data from this project will be used to develop a larger study
 comparing different treatment regimens for patients using alcohol to reduce the risks of
 hyperglycaemia as well as hypoglycaemia.
This is a randomised trial involving Type I diabetics who have had Type I diabetes >5 years.
 They will be using multiple daily injections of a basal insulin and a rapid acting
 component.Apart from insulin and oral contraceptive, none will be on regular medication. All
 will be regular consumers of modest amount of alcohol (Female - less than or equal to 14
 units, males - less than or equal to 21 units). Each will participate in 2 studies. Subjects
 will be randomised either to white wine or an equivalent volume of alcohol-free wine.Outcome
 measures are the results of the effect of acute ingestion of alcohol on glucose levels and
 intermediate metabolites in subjects with Type I diabetes.
Inclusion Criteria:

 -  Type 1 diabetes for > 5 years

 -  Use of multiple daily injections of a basal insulin and a rapid acting component

 -  Regular consumption of modest amounts of alcohol

 Exclusion Criteria:

 -  Type 2 diabetes

 -  Type I diabetes < 5 years

 -  Excessive alcohol consumption

 -  Unstable diabetes