Hyperbilirubinemia in Acute Appendicitis as a Predictor of Perforation
Hyperbilirubinemia in Acute Appendicitis as a Predictor of Perforation
It has recently been published that hyperbilirubinemia is a reliable marker for the
 preoperative diagnosis of perforated acute appendicitis.

 The investigators believe, based on their own previous publications, that C-reactive protein
 (CRP) with or without a white blood cell count and some other clinical parameters, are more
 specific markers for the preoperative diagnosis of perforated acute appendicitis.

 The purpose of this study is to prospectively compare the specificity and sensitivity of
 hyperbilirubinemia CRP, white blood cell count and other clinical parameters for the
 preoperative diagnosis of acute appendicitis.
-  Previously validated appendicitis score

 -  Time from onset of symptoms to diagnosis and to surgery

 -  Laboratory values: WBC, CRP, liver function test

 -  SIRS values

 -  Preoperative and postoperative diagnosis

 -  Length of hospital stay

 -  Postoperative complications

 -  Biopsy results
Inclusion Criteria:

 -  Patients scheduled for appendectomies for acute appendicitis at the emergency unit of
 our institution

 -  Patients older than 15 years of age to 100 years of age

 Exclusion Criteria:

 -  Appendectomy performed incidentally or for other indications

 -  Patients younger than 15 years of age

 -  Alcoholism

 -  A history of viral hepatitis

 -  Gilbert's disease

 -  Dubin Johnson syndrome

 -  BRIC (benign recurrent intra-hepatic cholestasis) and other documented biliary

 -  Hemolytic or liver diseases associated with hyperbilirubinaemia