Comparison of Bone Quality in Type 2 Diabetic Patients With a Non-diabetic Control Population
Comparison of Bone Quality in Type 2 Diabetic Patients With a Non-diabetic Control Population
Patients with type 2 diabetes have many complications in different organs. These
 complications are extremely frequent and severe: cardiovascular and renal disease, visual
 impairment, and, more recently, complications affecting bone such as fractures. Conventional
 methods for the evaluation of fracture risk are based on the Bone Mineral Density (BMD) or
 FRAX (algorithm for the prediction of osteoporotic fracture risk) are not sufficient in the
 context of diabetes. Several metaanalyses have shown that, paradoxically, a higher BMD in
 patients with type 2 diabetes compared to patients not suffering from this disease,
 independently of body mass index (BMI). The paradoxal increase in fracture risk, despite a
 high BMD has led to the hypothesis that diabetes induces a modification of the quality and
 not the quantity of bone. However, there is a lack of data as to bone quality in patients
 with type 2 diabetes as studies of bone biopsies from patients with type 2 diabetes are
 extremely rare.

 The objective of the study is to compare bone quality in patients with type 2 diabetes to
 that in patients who do not suffer from type 2 diabetes: evaluation of vertebral fractures by
 osteodensitometry, measurement of Trabecular Bone Score (TBS), and analysis of bone quality
 in biopsies (advanced glycation end products (AGE), contents of bone matrix and analysis of
 mineralization).

 The results will then be correlated with blood/urinary markers with the objective to
 determine one/several non-invasive biomarkers for bone status in diabetic patients.
Inclusion Criteria:

 -  Men and women aged greater than 40 years

 -  Patients requiring surgery of the lower limb

 -  With a bone mineral density considered normal (T-score ≥ -2)

 -  Stage 1, 2, or 3 glomerular filtration rate (> 30 mL/min)

 -  For diabetic patients the diagnosis will have previously established by an
 endocrinologist

 Exclusion Criteria:

 -  Subjects treated with drugs known to interfere with bone metabolism, including
 steroids, anticonvulsants, diuretics, and bisphosphonates

 -  Patients with severe renal disease (< 30 ml/mn); previous history of caner except skin
 cancer; myocardial infarction; uncontrolled hypertension; untreated hyperthyroidism;
 hyperthyroidism; malabsorption; bone metabolism diseases; rheumatoid arthritis or
 collagen diseases

 -  Pregnant or lactating woman

 -  Contraindication to taking tetracycline hydrochloride:

 -  Known hypersensitivity to antibiotics of the tetracycline family or any of the
 excipients in the medicine

 -  Severe chronic renal failure

 -  Chronic liver failure

 -  Systemic lupus erythematosus

 -  Concomitant prescription of retinoid or vitamin A (risk intracranial
 hypertension)

 -  Psychiatric pathology seriously hampering understanding

 -  Difficulty understanding oral French

 -  Not a beneficiary of a social security scheme