Treatment of Hypoparathyroidism With Subcutaneous PTH (1-84) Injections: Effects on Muscle Function and Quality of Life
Treatment of Hypoparathyroidism With Subcutaneous PTH (1-84) Injections: Effects on Muscle Function and Quality of Life
The aim of the study is to assess whether PTH (1-84) therapy posses advantages compared to
 conventional treatment in patients with hypoparathyroidism on muscle function, quality of
 life, calcium homeostasis, bone metabolism, and body composition.
Hypoparathyroidism is one of the only hormonal insufficiency states that is usually not
 treated by replacing the missing hormone. Currently, Standard therapy includes treatment with
 calcium and an 1alpha-hydroxylated forms of vitamin D (e.g. calcitriol or alphacalcidol) in
 order to relieve the symptoms associated with hypocalcaemia. However, recent studies have
 shown that calcium homeostasis can be well regulated by PTH replacement therapy in patients
 with hypoparathyroidism. It seems that PTH treatment is safe and that it even may posses
 advantages compared to conventional treatment with vitamin D. As the renal calcium excretion
 is decreased by PTH therapy, the risk of renal calcifications causing an impaired renal
 function may be reduced. In addition, some of the hypoparathyroid patients treated with PTH
 reported less fatigue and increased endurance in response to treatment. This may be due to
 either a better regulated (i.e. more physiological) calcium homeostasis during PTH therapy,
 or due to a direct effect of PTH on the neuromuscular system. Therefore, further studies are
 needed on the effects of PTH replacement in patients with hypoparathyroidism.

 Outcome measures:

 -  Muscle- and balance function: Effects of treatment on muscle strength and balance
 function are determined using a dynamometer and a stadiometer (Meititur Ltd, Finland).
 In addition, effects of treatment on muscle function are assessed through muscle
 biopsies, electromyographic, echocardiography, and by biochemical measures (muscle
 enzymes).

 -  Quality of life: Effect of treatment on indices of quality of life is assessed using the
 SF-36v2- and the WHO-Five Well-Being Index (WHO-5)-survey.

 -  Calcium homeostasis, bone metabolism, and body composition. Effects of treatment are
 assessed by measurements of calcitropic hormones, biochemical markers of bone turnover,
 and iliac crest biopsies. In addition, bone mineral density and body composition is
 measured.
Inclusion Criteria:

 -  A low endogenous PTH production as verified by low plasma levels of intact PTH,
 necessitating treatment with 1alpha-hydroxylated vitamin D analogs.

 -  At least one years of continuous alphacalcidol, calcitriol, or dihydrotachysterol
 treatment prior to study entry.

 -  Prior to start of study, participants are required to have received a daily supplement
 of at least 400 IU (10 microgram) of vitamin D (ergocalciferol or cholecalciferol) for
 at least 3 months or 25hydroxyvitamin D levels above 50 nmol/l. Subjects may be
 treated with ergocalciferol or cholecalciferol during a run-in period of three months
 before entering the study.

 -  Normal plasma magnesium level (If not, magnesium supplements may be provided during a
 3 months run in period).

 -  Plasma calcium levels within the normal reference range or slightly below (P-Ca
 ionized 1.00 to 1.30).

 -  Use of safe contraceptive methods (fertile women).

 -  Speak and read Danish.

 Exclusion Criteria:

 -  Known allergic reactions to any of the compounds in the trial medication.

 -  Severely impaired renal function (plasma creatinine > 200 micromol/l).

 -  Severely impaired hepatic function (Plasma alanine aminotransferase (ALAT) > 100 U/l
 and/or alkaline phosphatase > 400 U/l).

 -  Previous or present malignancies (except a treated skin cancer that is not melanoma or
 treated carcinoma in situ, 2 years since last therapy).

 -  Prior radiation therapy involving the skeleton.

 -  Current treatment with raloxifene, calcitonin, systemic corticosteroids above 5 mg a
 day, fluoride, lithium, PTH, or digoxin.

 -  Treatment with anticonvulsant's (within the last 2 years).

 -  Immobilization (more than two week within the last 6 months).

 -  Granulomatous disease.

 -  Paget's disease of bone.

 -  Pregnancy / planned within the next year. Hospitalized due to chronic drug or alcohol
 abuse. Severe malabsorption syndrome.

 -  Major medical or social problems that will be likely to preclude participation for one
 year.

 -  Unwillingness to participate.