Diagnostic Value of AFP-L3 and PIVKA-II in HCC
Diagnostic Value of AFP-L3 and PIVKA-II in HCC
The incidence of Hepatocellular carcinoma (HCC) is increasing worldwide. However, most of HCC
 cases were at advanced stage when the diagnosis established.Early diagnosis improves the
 prognosis.The study is intended to evaluate the diagnostic efficiency of alpha-fetoprotein-L3
 (AFP-L3) and Protein Induced by Vitamin K Absence or antagonist-II (PIVKA-II). This study is
 performed at Hanoi Medical University Hospital. Participants including patients with HCC and
 hepatic hemangioma. All the serum samples are collected before any treatments and will be
 tested in single center in order to decrease bias. Serum samples were tested for PIVKA-II,
 AFP, AFP-L3 and biochemical indexes including alanine aminotransferase(ALT),aspartate
 aminotransferase (AST), gamma-glutamyl transferase, HbsAg, Anti HCV, etc.
Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide.Early
 diagnosis improves the prognosis. Protein induced by vitamin K antagonist-II (PIVKA-II), also
 known as des-γ-carboxyprothrombin (DCP) or acarboxy prothrombin, is an abnormal form of
 prothrombin induced by vitamin K absence or antagonist-II. The study is intended to evaluate
 the diagnostic efficiency of AFP-L3 and PIVKA-II. AFP-L3 and PIVKA-II as an effective tumor
 marker for hepatocellular carcinoma(HCC). Despite the extensive application of PIVKA-II in
 some hospitals from Vietnam, the diagnostic efficiency including sensitivity, specificity,
 positive predictive value and negative predictive value still needs more clinical data to
 evaluate. The research purposes list as follows：1. Determination of changes in AFP-L3 and
 PIVKA II for HCC.2. Investigating the diagnostic value of AFP-L3 and PIVKA II for HCC. This
 study is performed at Hanoi Medical University Hospital. Participants including patients with
 HCC and hepatic hemangioma. All the serum samples are collected before any treatments and
 will be tested in single center in order to decrease bias. Serum samples were tested for
 PIVKA-II, AFP, AFP-L3 and biochemical indexes including alanine
 aminotransferase(ALT),aspartate aminotransferase (AST), gamma-glutamyl transferase, HbsAg,
 Anti HCV, etc.The diagnosis of HCC was based on HCC criteria of Ministry of Public Health of
 Vietnam. All HCC diagnoses were confirmed at the time of analysis. Stages of tumor is
 evaluated by Barcelana classification. The Student's t-test (or Mann-Whitney test) was used
 to compare continuous variables, and the chi-square test (or Fisher's exact test) was used
 for categorical variables. A receiver operator characteristic (ROC) curve was used to assess
 the performance characteristic of PIVKA-II,AFP,AFP-L3 measurement.
Inclusion Criteria:

 -  Age between 18 and 85

 -  Receiving no treatment before diagnosis

 -  Establishing Diagnosis according to thecriteria of Ministry of Public Health of
 Vietnam 2012.

 Exclusion Criteria:

 -  Clinical data missing

 -  Laboratory tests information missing

 -  Serum samples doesn't qualified

 -  Obstructive jaundice patients

 -  Medical history of taking warfarin