Vitamin B6 on Relieving Linezolid-associated Cytopenias
Vitamin B6 on Relieving Linezolid-associated Cytopenias
Linezolid is the first approved synthetic oxazolidinone that is active against
 multidrug-resistant Gram-positive pathogens. Because of its significant efficacy, linezolid
 is widely used in clinical treatment. However, the side effects of linezolid commonly lead to
 anemia and thrombocytopenia. This hematological toxic effects limit its prolonged used. The
 investigators have found that Vitamin B6 application, as a preventive, auxiliary therapy, can
 relieve anemia and thrombocytopenia. The present study was designed to verify the effects of
 Vitamin B6 in the prevention of linezolid-associated cytopenias and investigate its
 mechanism.
Infected patients receiving linezolid therapy are divided into two groups, i.e. the linezolid
 group and the linezolid + vitamin B6 group, the line of division being whether vitamin B6 is
 to be applied or not in the course of treatment. The purpose is to evaluate the role that
 vitamin B6 plays, during the process of linezolid therapy, in the relief of erythropenia and
 cytopenias.
Inclusion Criteria:

 -  Use of linezolid is not less than 3 days

 Exclusion Criteria:

 -  Serious adverse reactions