Effects of High Dose Atorvastatin in Patients With Surgical Aortic Stenosis
Effects of High Dose Atorvastatin in Patients With Surgical Aortic Stenosis
The purpose of the study is to see if statin therapy will optimize myocardial response to
 cardiopulmonary bypass during aortic valve replacement (AVR) for aortic valve stenosis (AVS)
 (Phase I) and optimize left ventricular reverse remodeling following AVR (Phase II).
 Preliminary evidence indicates that perioperative statin therapy reduce mortality and
 morbidity following cardiac surgery. Pleiotropic effects of statins may induce myocardial
 preconditioning and optimize myocardial and systemic responses to cardiopulmonary bypass
 during AVR. Furthermore statin therapy after AVR may contribute to an optimal left
 ventricular reverse remodeling.
Inclusion Criteria:

 -  Age > or = 70 years and < 80 years

 -  Severe aortic valve stenosis

 -  Indication for aortic valve replacement by bioprothesis

 -  Ejection fraction > or = 50%

 -  Without treatment with statin- No renal failure

 -  Informed consent signed

 Exclusion Criteria:

 -  Ischemic heart disaese

 -  Concomitant surgery to aortic valve replacement

 -  Emergency surgery- Known intolerance for statin

 -  Pregnant woman