Descriptive Epidemiology of Clostridium Difficile Infection in Hospitalized Adult Patients in the Asia Pacific Region
Descriptive Epidemiology of Clostridium Difficile Infection in Hospitalized Adult Patients in the Asia Pacific Region
Clostridium difficile is an important pathogen, causing disease that ranges from mild
 self-limited diarrhea to life-threatening pseudomembranous colitis. It is estimated that C.
 difficile is responsible for 10% to 25% of all cases of antibiotic-associated diarrhea and
 for almost all cases of pseudomembranous colitis. C. difficile disease is mediated by two
 large toxins, A and B. The toxins damage intestinal epithelial cells and cause the clinical
 illness. Primary risk factors for C. difficile clinically apparent infection include
 antimicrobial therapy, hospitalization, residence in a long-term care facility, older age (≥
 65 years), and increased length of hospital stay. The incidence of CDI both in the hospital
 and the community is important in the understanding and characterization of the disease and
 its prevention. This observational, epidemiological study will advance the investigators
 understanding of CDI risk factors in several hospitals and possibly the community in the Asia
 Pacific region.
Inclusion Criteria:

 -  Adult patients, aged ≥ 20 years at the time of hospitalization in specified wards

 -  PCR-diagnosed CDI while at the hospital

 -  Informed consent has been obtained from patients as required by local requirements

 Exclusion Criteria:

 -  Age < 20 years