Randomized Comparison of Laparoscopic Sleeve Gastrectomy and Gastric Bypass for Morbid Obesity
Randomized Comparison of Laparoscopic Sleeve Gastrectomy and Gastric Bypass for Morbid Obesity
Bariatric surgery is the most effective treatment for morbid obesity. Roux-en-Y gastric
 bypass (RYGB) is a bariatric procedure with known safety and effectiveness. Laparoscopic
 sleeve gastrectomy (LSG) is a newer procedure gaining popularity. The aim of the study is to
 compare outcomes of these two surgical methods in terms of weight loss, improvement of common
 comorbidities of obesity and influence on metabolic and hormonal status.
Authors of the study believe that a more detailed head-to-head comparison of RYGB and LSG is
 necessary. The former method is the established "gold standard" procedure with good outcomes
 reported in many studies. However it is much more complex and the learning curve is longer.
 The latter method was introduced as an initial procedure in superobese patients because of
 its relative simplicity. It produced good outcomes in this population of superobese patients
 and surgeons in some centers started to use it as a primary bariatric procedure. RYGB is a
 restrictive and partially malabsorptive procedure and it is believed to have additional
 benefits in patients with metabolic disorders such as type 2 diabetes and dyslipidemia.
 Purely restrictive procedures such as LSG are theoretically less beneficial in this group of
 patients. In the present study authors will look at weight loss as well as improvement in
 comorbidities and several biochemical parameters and indices to assess also metabolic action
 of these two procedures.
Inclusion Criteria:

 -  BMI≥40 kg/m2

 -  BMI≥35 kg/m2 with at least one comorbidity associated with obesity

 Exclusion Criteria:

 -  BMI > 60 kg/m2

 -  poorly controlled significant medical or psychiatric disorders

 -  active alcohol or substance abuse

 -  active duodenal/gastric ulcer disease

 -  difficult to treat gastro-esophageal reflux disease with a large hiatal hernia

 -  previous major gastrointestinal surgery

 -  diagnosed or suspected malignancy