Peripheral Transcutaneous Neuromodulation of the Post-tibial Nerve for Solifenacin 10 mg. Hyperactive Bladder Syndrome
Peripheral Transcutaneous Neuromodulation of the Post-tibial Nerve for Solifenacin 10 mg. Hyperactive Bladder Syndrome
-  To determine if the T-PTNS is not inferior in the short term (3 months) to one of the
 usual pharmacological treatments (Solifenacin) in the treatment of hyperactive bladder
 syndrome and with respect to the percentage of patients that improve 50% any of the 3
 signs (Urinary frequency, diurnal / nocturnal frequency, urgency and urinary
 incontinence).

 -  To determine prognostic factors associated with insufficient improvement (less than 50%
 in the 3 main signs of hyperactive bladder syndrome (urinary frequency, urgency and
 urinary incontinence frequency) after treatment with T-PTNS and Solifenacin.
Patients will be randomized to receive the usual standard treatment with Solifenacin or
 treatment based on peripheral unilateral transcutaneous neuromodulation of the posterior
 tibial nerve .
Inclusion Criteria:

 -  Women> 18 years, diagnosed with hyperactive bladder syndrome for at least 6 months of
 evolution and who have taken Beta 3 agonists

 Exclusion Criteria:

 -  Patients who can contribute biased information: have previously consumed and abandoned
 anticholinergic drugs due to lack of efficacy or side effects; Suffering from
 hyperactive bladder of neurogenic origin (multiple sclerosis, Parkinson's, spinal cord
 injury); Present cystocele or any pelvic organ prolapse> 2 according to Pelvic Organ
 Prolapse-Q classification

 -  Patients who may become worse with the interventions envisaged in the study: being a
 implantable automatic defibrillators; With cutaneous alterations in lower extremities
 that prevent the placement of electrodes on the surface; Women who are pregnant or who
 may be pregnant during the duration of the clinical trial (prior and at each
 evaluation visit urine Bhcg will be requested to rule out pregnancy) or patients who
 are not able to manage transcutaneous electrical neurostimulation on an outpatient
 basis ) Or patients in whom Solifenacin is contraindicated: urinary retention, severe
 gastrointestinal disorders (including toxic megacolon), myasthenia gravis, or
 narrow-angle glaucoma, and in patients at risk of these conditions as hypersensitive
 at first Active or to any of the excipients, undergoing hemodialysis, with moderate
 hepatic insufficiency or severe renal insufficiency or in simultaneous treatment with
 a potent inhibitor of CYP3A4, eg ketoconazole.