EXPRESON-IN : Intracerebral Recordings of P3a Responses to Expressive Own-names
EXPRESON-IN : Intracerebral Recordings of P3a Responses to Expressive Own-names
Neurophysiologic evaluation of disorders of consciousness (DOC) patients inintensive care
 unit include late auditory evoked potentials. It allows the physicians to record cerebral
 responses of patients to auditory stimuli and in particularly to their own name (as the P3a
 response). Numerous studies try to improve the relevance of the auditory stimuli used in this
 paradigm and notably using more expressive stimuli.

 Here the investigators investigate the intracerebral correlates of the P3a responses recorded
 on the scalp with neutral and more expressive stimuli.
Late auditory evoked potentials (as P3 wave) are used in neurophysiology to assess the level
 of consciousness in DOC (disorder of consciousness) patients. The P3 wave, elicited by
 listening standard and deviant stimuli, corresponds to the activation of a frontoparietal
 network and is considered to reflect a cognitive attention task. Using the own name of the
 patient as deviant stimuli improve the ability to detect the P3 wave because of the
 particularly relevance of this stimulus for the patient.

 In human cognition, to identify the expressivity valence of a voice is essential. Neural
 processing of expressive voices should involves more widespread brain areas than neutral
 voices processing.

 Here the investigators investigate the intracerebral correlates of the P3a responses recorded
 on the scalp to own-name stimuli uttered by neutral and more expressive voices (positive :
 smiling voice or negative : rough voice) in adult pharmacoresistant epilepsy patients.
Inclusion Criteria:

 -  Intractable focal epilepsy with undergoing pre-surgical evaluation

 -  intracerebral electrodes implantation in auditory cortices, temporal lobe, superior
 temporal gyrus, limbic areas, frontal lobe

 -  Given Consent to inclusion

 Exclusion Criteria:

 -  Deafness

 -  Pregnancy