The Use of Technology to Improve MS Clinical Trials and Patient Care
The Use of Technology to Improve MS Clinical Trials and Patient Care
Many patients with multiple sclerosis (MS) experience "relapses" of disease activity during
 which they have increased numbness, weakness, visual problems, or other symptoms. If a person
 with MS has new symptoms that are concerning to them, their doctor may want to see them in
 the office in order to confirm that these symptoms are due to a true "relapse" of activity
 before starting relapse treatment. This requirement can be frustrating for patients, who may
 have to take time off from work or travel long distances for such unexpected doctors' visits.
 In this study, the investigators will use input from patients with MS and MS physicians to
 create a relapse questionnaire that can be used to confirm a relapse has occurred. The
 investigators will also evaluate if having a more direct line of communication with the
 provider's office improves overall patient care and satisfaction.
This research is being done to study if a relapse questionnaire for people with multiple
 sclerosis (MS) may help more easily determine if a relapse has occurred.

 A further goal of this study is to determine if receiving periodic messages from the doctor's
 office, as well as having the direct contact information of a person in the office, improves
 the care of the patients and their experience thereof.
Inclusion Criteria:

 -  English speakers

 -  Relapsing-remitting MS (2010 criteria)

 -  Expanded Disability Status Scale (EDSS) ≤6.0

 -  Possession of a smartphone OR of a mobile telephone with text messaging AND an e-mail
 account AND web access OR willingness to be provided with, and utilize, a smartphone
 for the duration of the study

 -  In the two years before screening:

 at least two relapses, OR one relapse and two new lesions (unrelated to relapse symptoms)
 on magnetic resonance imaging (MRI), OR RRMS (MAGNIMS 2010 criteria) onset within the past
 year with no exposure to disease modifying therapies (DMT)

 -  Patient is starting one of the following MS therapies: injectable (subcutaneous
 interferon beta or glatiramer acetate) or oral (fingolimod, teriflunomide, or dimethyl
 fumarate) therapies

 -  Relapse and MRI activity occurred while untreated or despite one single treatment, and
 no change in therapy since that activity

 -  Lives within 100 miles of Johns Hopkins Medical Center (Baltimore, MD)

 Exclusion Criteria:

 -  History of DMT exposure if MAGNIMS 2010 criteria used to enroll patients with disease
 onset in the past year, or change in MS therapy since qualifying relapse/MRI criteria
 occurred