Study by Magnetic Resonance Imaging in the Progressive Forms of Multiple Sclerosis
Study by Magnetic Resonance Imaging in the Progressive Forms of Multiple Sclerosis
The goal of this study is to show pattern differences of vasoreactivity and connectivity
 between Progressive Multiple Sclerosis and Relapsing Remitting Multiple Sclerosis, by the use
 of methods of advanced brain MRIs and the Diffusion Tensor Imaging , and correlate these
 differences with Clinical disability and cognitive disorder results.
The goal of this study is to show pattern differences of vasoreactivity and connectivity
 between Progressive Multiple Sclerosis and Relapsing Remitting Multiple Sclerosis, by the use
 of methods of advanced brain MRIs, and correlate these differences with Clinical disability
 and cognitive disorder results. The modification of the Diffusion Tensor Imaging are well
 known in these two groups, as well as their link with the occurrence of movement and
 cognitive disorder. The study of the vasoreactivity during MRI aims to confront our results
 to the available data sources.
Inclusion Criteria :

 -  For Both patients and healthy volunteers :

 -  Age limits ≥ 30 et ≤ 50 years

 -  Subject able to understand the nature, the aim and the methodology of the study.

 -  Collection of the informed consent

 -  Affiliation or recipient with the mode of social security.

 -  For the patients :

 -  Suffering from progressive multiple sclerosis (primary progressive forms or secondary
 progressive forms) OR

 -  Suffering from relapsing-remitting multiple sclerosis

 Exclusion Criteria :

 -  For Both patients and healthy volunteers :

 -  Systemic pathology with neurological manifestations

 -  Antecedent of psychiatric disorders including psychosis (Except anxious depressive
 disorder)

 -  Subject presenting contraindications in MRI (Ferromagnetic foreign bodies, pace-maker)

 -  Claustrophobia

 -  Women pregnant or Breast-feeding

 -  Person with majority age protected by the law (supervision, trusteeship or under
 safeguard of justice).

 -  Subject unable to understand the nature and the aim of the study and/or communication
 difficulties with investigator

 -  Antecedent of serious cranial trauma (according to classification) of ischaemic stroke
 ou intracranial hematoma.

 -  For the patients :

 -  Antecedent of serious cranial trauma (according to classification), anterior or
 evolutive neurologic disease other than multiple sclerosis

 -  Recent relapse of multiple sclerosis

 -  For the healthy volunteers :

 -  Antecedent of serious cranial trauma (according to classification), anterior or
 evolutive neurologic disease

 -  Antecedent of neurological disease

 -  In period of exclusion relative to another protocol or which the annual amount of the
 allowances maximum of 4500 € was reached.