Proof of Concept Study of RHB-104 as Add-On Therapy to Interferon Beta-1a in Relapsing Remitting Multiple Sclerosis (RRMS)
Proof of Concept Study of RHB-104 as Add-On Therapy to Interferon Beta-1a in Relapsing Remitting Multiple Sclerosis (RRMS)
The investigators hypothesize that Mycobacterium avium paratuberculosis positive Relapsing
 Remitting MS subjects will have a greater response to Interferon beta-1a therapy plus RHB-104
 than from Interferon beta-1a alone.
Inclusion Criteria:

 -  Males and females aged ≥18 years

 -  Signed fully informed consent provided as per this protocol and willing to comply with
 the required scheduled assessments of the protocol.

 -  Diagnosis of relapsing-remitting multiple sclerosis (McDonald Criteria (2010)) with
 dissemination in time and space.

 -  Currently treated with a stable dose of Rebif®, or Avonex® for a minimum of 3 months
 duration prior to the screening visit.

 -  Active MS with history of at least one flare within the past 12 months or two flares
 in the past 24 months prior to screening.

 -  An Expanded Disability Status Scale (EDSS) of 6.0 or less at the screening visit.

 -  White blood cell count ≥ to 3.5x109.

 -  Subject agrees to use barrier contraceptive methods (i.e. diaphragm, cervical cap,
 contraceptive sponge or condom) with spermicidal foam/gel/cream/suppository, or IUD
 from study enrolment through 6 weeks after last dose of study medication, unless
 subject is post-menopausal or otherwise incapable of becoming pregnant by reason of
 surgery or tubal ligation, or has had a vasectomy. Subject agrees to appropriate
 contraception method though completion of study.

 Exclusion Criteria:

 -  Treatment with any other biological therapies including but not limited to Interferon
 beta-1b, natalizumab, anti-TNF biologic agents, or other agents intended to reduce TNF
 ≤ 8 weeks prior to screening or within 5 half-lives of agent prior to screening,
 whichever is longer.

 -  Previous treatment with rifabutin and/or clofazimine.

 -  Previous treatment with amiodarone.

 -  Oral or parenteral antibiotics in the 4 weeks prior to screening. (Topical antibiotics
 are permitted.)

 -  Use of Methylprednisolone sodium succinate, prednisone, or any other corticosteroid
 during the 30 days prior to screening.

 -  Relapse within the 30 days prior to screening, or between screening and baseline.

 -  Initiation or dose modification of 4-aminopyridine within 60 days of screening.

 -  Use of azathioprine, 6-mercaptopurine (6-MP), methotrexate, cyclosporine or
 mycophenolate (CellCept) within 8 weeks prior to screening.

 -  Use of glatiramer acetate, cyclophosphamide, or plasma exchange within 12 weeks prior
 to screening.

 -  Use of mitoxantrone within one year prior to screening.

 -  Any previous treatment with cladribine, T cell vaccine, or altered peptide ligand.

 -  Previous total body irradiation or total lymphoid irradiation.

 -  Treatment with any medication that causes QT prolongation or Torsades de Pointes
 within 7 days prior to initiation of study drug, including but not limited to:
 Cisapride, pimozide, astemizole, terfenadine, ergotamine, dihydroergotamine,
 quinidine, procainamide, disopyramide, sotalol, ibutilde, dofetilide, dronedarone,
 ondansetron or other 5-HT3 receptor agonists, citalopram dose greater than 20 mg/day,
 tolteridine and quinine.

 -  Treatment with the following medications within 7 days prior to initiation of study
 drug: colchicine, roflumilast, apixabin, latuda, nefazodone, buspirone, fluvoxamine,
 simvastatin, lovastatin, atorvastatin, amlodipine, diltiazem, felodipine, nifedipine,
 nitrendipine, nisoldipine, fluconazole, ketoconazole, voriconazole, St. Johns wort,
 grapefruit juice, antiretroviral agents, alprazolam, alfentanyl, aprepitant,
 aripiprazole, cyclosporine, boceprevir, carbamazepine, haloperidol, digoxin,
 propranolol, carvedilol, metoprolol, and estrogens.

 -  Adverse reaction or hypersensitivity to the study drug or any medications related to
 the study drug.

 -  Clinically significant abnormalities of hematology or chemistry at screening as
 confirmed by repeat testing based on investigator's discretion, including but not
 limited to, elevations greater than 2 times the upper limit of normal of Aspartate
 Aminotransferase (AST), Alanine Aminotransferase (ALT), or creatinine clearance less
 than 60 ml/min at screening.

 -  Serum potassium, magnesium or calcium outside the normal reference range considered
 clinically significant by the investigator.

 -  Positive stool results for C. difficile.

 -  A positive serology for Hepatitis B, Hepatitis C or HIV at screening except for the
 following:

 If positive history of previously treated Hepatitis C, but HCV PCR is undetectable off
 medications for at least 6 months prior to screening, and treating hepatologist or
 infectious disease specialist believes the subject is cured - subject may be enrolled

 -  One of the following:

 History of atypical mycobacterial infections (other than MAP). History of active
 tuberculosis (TB) requiring treatment in the past 3 years. Tuberculosis infection as
 determined by a positive diagnostic TB test result (defined as a positive or indeterminate
 (after two independent tests) quantiFERON TB Test Gold test).

 -  Currently diagnosed or history of uveitis confirmed by either an ophthalmologist or
 optometrist.

 -  Any evidence of any other significant hematological, hepatic, renal, cardiac,
 pulmonary, metabolic, thyroid, neurological or psychiatric disease that might
 interfere with the subject's ability to safely enter and or complete the study
 requirements.

 -  History of malignancy within the past five years except for basal cell carcinoma of
 the skin or carcinoma in situ of the cervix that has been treated with no evidence of
 recurrence.

 -  Males who do not use barrier contraceptive methods (i.e. condom) with spermicidal
 foam/gel/cream/suppository or have not had a vasectomy.

 -  Females who:

 1. have a positive pregnancy test

 2. are lactating

 -  Refusal to sign the study informed consent form.

 -  Inability to adequately communicate with the investigator or their respective designee
 and/or comply with the requirements of the entire study.

 -  History of drug or alcohol abuse within the past 3 years.

 -  Participation in any experimental drug protocol within 12 weeks of date of screening.

 -  Cardiac pacemaker or any other type of metal implant or any other contraindication for
 MRI (including known allergy to gadolinium).

 -  QTc greater than 440ms, bundle branch block, or major ST or T wave abnormalities that
 make the assessment of the QT impossible.

 -  History of unstable cardiac syndromes including unstable angina, coronary artery
 bypass graft, myocardial infarction or coronary stenting within 2 months of screening;
 NYHA Class 3-4 CHF; history of ventricular tachycardia, ventricular fibrillation,
 personal or family history of sudden death, Long QT Syndrome, or Torsade de Pointes;
 HR<50BPM; having taken any Class 1 or Class 3 antiarrhythmic medications or medicines
 known to prolong the QT interval or be associated with Torsade de Pointes.

 -  Treatment with medical cannabis in the 4 weeks prior to screening.