Expression of CVD and HA Between Obesity and Non-obesity Polycystic Ovary Syndrome (PCOS) Women in Taiwan
Expression of CVD and HA Between Obesity and Non-obesity Polycystic Ovary Syndrome (PCOS) Women in Taiwan
Polycystic Ovarian Syndrome (PCOS) is the most common endocrine disorder in reproductive
 women. It is estimated that 5 to 10% of women of reproductive age have PCOS. One of the major
 diagnostic criteria of PCOS was chronic anovulation which lead to irregular menstruation,
 amenorrhea, and infertility; the other diagnostic criteria was hyperandrogenism which lead to
 hirsutism, acne and alopecia. Furthermore, PCOS is thought as a metabolic disorder, the
 long-term consequence of PCOS were diabetes mellitus and cardiovascular disease, which are
 potentially dangerous in women health. Early diagnosis and prevention is very important to
 the PCOS patients.

 Obesity is the most potential risk of threat to health of populations. There is a major
 impact of obesity on the PCOS related disorders. Insulin resistance and distribution of
 adipose tissue were thought to be the important risk factors of cardiovascular and metabolic
 syndrome. To treat PCOS patients properly,Wan-Fang hospital had established a specific
 medical team. We recently published in "Fertility and Sterility" about the clinical
 presentation of androgen excess in Taiwanese women. Hirsutism is much less prevalence (30%)
 in Taiwanese PCOS women than that previous reported (65-80%) in theWestern women. It is
 important to know that some clinical presentation of PCOS might have ethic variance. Insulin
 resistance was reported as another candidate that might have ethic variance.We had reported
 about 40% women in PCOS women were obese, it is similar with previous literature reported.
 Obesity is a major factor that could be controlled during the treatment of PCOS.Weight
 reduction is one of our methods in PCOS treatment. The progressive results for obese PCOS
 women would be facing the risks of diabetes and metabolic syndrome.We thought like to
 evaluate the benefit of weight reduction program to the prognosis of obese women with PCOS.

 Furthermore, it is known that Endothelial progenitor cells (EPC) be an early marker of
 cardiovascular disease, we would like to know the role of EPC to predict metabolic syndrome
 in women with PCOS. Wan-Fang hospital has a professional team in PCOS treatment and research
 which including gynecological endocrinologist, cardiologist, medical endocrinologist,
 specialist in weight reduction. This team had been working well for more that 4 years.

 We hope we can make a contribution to the study and treatment of PCOS in Taiwan.
Inclusion Criteria:

 -  women who had visited the Reproductive Endocrinology Clinic at Taipei Medical
 University - Wan Fang Medical Center during April 2004 - March 2007 with the chief
 complaints of menstrual irregularities, infertility, acne/or hirsutism.

 Exclusion Criteria:

 -  women who had been diagnosed with androgen-secreting tumors.

 -  girls who had their menarche less than 3 years prior to the study, or who older than
 40.

 -  women with inadequate clinical/biochemical records.