Prostatic Artery Embolization for Obstructive Uropathy Due to Prostate Cancer
Prostatic Artery Embolization for Obstructive Uropathy Due to Prostate Cancer
The aim of this study is to investigate the safety and efficacy of prostatic artery
 embolization of patients with recurrent symptoms secondary to locally advanced prostatic
 cancer including pelvic pain, bleeding or need for permanent urinary catheter who are unfit
 for or refuse surgical treatment.
This is a prospective study investigating the safety and efficacy of PAE for patients with
 prostate cancer who suffers from acute urinary retention, severe LUTS and/or recurrent
 complications such as haematuria.

 Our hypothesis is that PAE will eliminate the need for indwelling catheter and improve IPSS
 and QoL 12 months post-procedure.

 1, and 6 months follow-up.

 Main outcome Ability to void after removal of indwelling catheter

 Secondary outcomes International Prostate Symptom Score (IPSS) Quality of Life (QoL)
 International Index of Erectile Function (IIEF) Prostate volume Peak void flow (Qmax)
 Post-void residual (PVR) Classify complications according to Society of Interventional
 Radiology (SIR) guidelines for reporting Prostate-specific antigen (PSA)
Inclusion Criteria:

 -  Indwelling catheter secondary to locally advanced prostate cancer (PCa) or

 -  Moderate-severe Obstructive LUTS secondary to PCa

 -  Unsuitable for or refuse surgery

 Exclusion Criteria:

 -  Bladder dysfunction(and known neurological conditions affecting bladder function)

 -  Urethral strictures

 -  Bladder neck contracture

 -  Known sphincter anomalies

 -  Big bladder diverticulum or stones

 -  Kidney insufficiency (eGFR < 45)

 -  Coagulation disturbances

 -  Severe atheromatous or tortuosity of arteries

 -  Allergy to contrast medium

 -  Unable to undergo MR imaging

 -  Bladder malignancy