The Influence of Cholecystectomy on Secretion of Incretin Hormones
The Influence of Cholecystectomy on Secretion of Incretin Hormones
The effect of cholecystectomy on postprandial plasma GLP-1 responses (primary endpoint) and
 glucose metabolism will be evaluated in 30 patients planned to undergo elective laparoscopic
 cholecystectomy.
This is an observational, parallel-group study in 30 patients with gallstone disease and 10
 healthy control subjects. In patients undergoing cholecystectomy a 4h-meal test (liquid mixed
 meal) will be conducted at baseline (1-2 weeks before surgery) and again within 4 weeks after
 the cholecystectomy. Healthy subjects will be submitted to a single 4h-meal test.

 Secondary endpoints include changes in plasma glucose, insulin, glucagon, GIP, PYY, gastrin,
 CCK, fibroblast growth factor 19 (FGF-19) and bile acids. Furthermore, secondary endpoints
 include changes in gastric emptying (evaluated by the paracetamol method).
Inclusion Criteria:

 -  caucasians above 18 years of age, having an elective cholecystectomy performed because
 of gallstone disease.

 -  normal fasting plasma glucose and HbA1c

 -  normal hgb

 -  Normal gallbladder ejection fraction

 Exclusion Criteria:

 -  liver disease

 -  kidney disease

 -  diabetes

 -  ongoing infection

 -  abdominal pain not related to gall stones

 -  BMI <18,5 kg/m2 eller BMI >27 kg/m2

 -  prior abdominal surgery