Vancomycin in the Target Site Treatment of Intracranial Infection
Vancomycin in the Target Site Treatment of Intracranial Infection
Vancomycin, a novel intravenously administered antibiotic, currently plays a key role in the
 management of complicated multi-organism infections. However,current LC-MS/MS methods briefly
 describe parameters and the only reported internal standard was sometimes difficult to
 obtain. In our study,an updated LC-MS/MS method for the quantitative analysis of vancomycin
 in human serum was developed.
Inclusion Criteria:

 In ICU; ventricle drainage was carried out; renal function is normal, namely creatinine
 clearance rate is >60ml/min;

 Exclusion Criteria:

 women in pregnancy or lactation;in patients with renal insufficiency, the creatinine
 clearance rate (Clcr) is less than 60ml/min.