A Single Dose Study of Radiolabeled RO4602522 in Healthy Volunteers
A Single Dose Study of Radiolabeled RO4602522 in Healthy Volunteers
This single-center, open-label study will investigate the pharmacokinetics and elimination of
 a radiolabelled dose of RO4602522 in healthy male volunteers. The healthy male volunteers
 will receive a single oral dose of RO4602522.
Inclusion Criteria:

 -  Healthy male volunteers, 35 to 55 years of age, inclusive

 -  Healthy status is defined by absence of evidence of any active or chronic disease
 following a detailed medical and surgical history, a complete physical examination
 including vital signs, 12-lead electrocardiogram (ECG), hematology, blood chemistry,
 serology and urinalysis

 -  A body mass index (BMI) between 18 to 30 kg/m2 inclusive

 -  Male volunteers and their partners of childbearing potential must use 2 methods of
 contraception, one of which must be a barrier method for the duration of the study and
 for 90 days after the last dose.

 -  Able to participate and willing to give written informed consent and to comply with
 the study restrictions.

 -  Non-smokers or have not smoked since at least 3 months prior to screening

 Exclusion Criteria:

 -  If capable of reproduction, unwilling to use an effective form of contraception

 -  Suspicion of regular consumption of drug of abuse and/or positive drug or alcohol
 screen

 -  Infection with hepatitis B, hepatitis C, or human immunodeficiency virus 1 and 2

 -  Systolic blood pressure greater than 140 or less than 90 mm Hg, and diastolic blood
 pressure greater than 90 or less than 50 mm Hg

 -  Resting pulse rate greater than 90 or less than 45 beats per minute

 -  Clinically significant abnormalities in laboratory test results

 -  Participation in an investigational drug or device study within 90 days prior to
 screening

 -  Donation of blood within 3 months prior to screening

 -  Concomitant disease or condition that could interfere with, or treatment of which
 might interfere with, the conduct of the study, or that would, in the opinion of the
 investigator, pose an unacceptable risk to the subject in this study