Efficacy of Morphine in Reducing the Rate of Early Non-Invasive Ventilation Failure in Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Phase I/IIa
Efficacy of Morphine in Reducing the Rate of Early Non-Invasive Ventilation Failure in Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Phase I/IIa
Acute exacerbations of Chronic Obstructive Pulmonary Disease (COPD) are a major source of
 morbidity and mortality for patients and cost to the society. In case of acute respiratory
 failure with hypercapnia and acidosis, Non Invasive Ventilation (NIV) is preferred as a first
 line treatment.

 NIV failures are not uncommon, from 15% in intensive care to 25 - 30% in emergency
 departments. They most often occur at the start of the NIV or in the hours that follow. There
 are many reasons for these failure. Among these are; dyspnea, discomfort, the pain related to
 the exacerbation and also to the NIV are frequently noted.

 The use of certain drugs with anxiolytic, hypnotic and/or analgesic properties could also be
 useful. Some sedatives and opioids have already been studied in this indication but without a
 therapeutic trial and satisfactory methodology. Among the molecules of interest, Morphine
 seems interesting . It's administration could reduce the ventilatory rate, intensity of
 dyspnea, pain and anxiety as well as dynamic hyperinflation.

 The investigators believe that morphine administration will decrease the rate of early NIV
 failure by improving comfort (decreased dyspnea and pain) and ventilation (decreased
 respiratory rate and increase in tidal volume) in patients with exacerbations of COPD.

 However, before considering a randomized phase III efficacy study, it is necessary to
 determine the optimal dose of morphine in this indication, through a phase I/II dose-finding
 study taking into accounts both the efficacy and toxicity of morphine.

 The main objective of this study, is to determine the optimal dose of morphine administered
 at the initiation of NIV in patient with acute Exacerbation of Chronic Obstructive Pulmonary
 Disease (COPD), which is defined as the maximum gain function combining the probability of
 dose-limiting toxicity with PaCO2.Therefore, the impact of morphine administration on the
 physiological parameters of NIV- COPD exacerbation patients will be assessed.
Patients included in this dose-finding study will be enrolled consecutively after consent and
 verification of the selection criteria, with a minimum of 24 hours after completion of
 previous patient follow-up.

 Prior to the administration of morphine, the following exams will be performed: clinical,
 paraclinical and biological parameters.

 NIV will be started and performed in BiPAP pressure mode with facial mask. A Tidal Volume
 (Vt) to the maximum of 6 - 8ml/kg, an expiratory positive airway pressure (EPAP) of 5cm H2O
 and the FiO2 set at 35%. The settings will be adapted according to the SpO2 (88%≤SpO2≤92%)
 and the clinical tolerance.

 Thereafter, the patients included will receive a single open-label injection of morphine (T0)
 at the dose closest to that defined by the model (estimation by Bayesian method) from among
 the following 4 doses: 0.02; 0.04; 0.07 and 0.1mg/kg.

 A double check of the preparation of the dose administered will be carried out by a physician
 and a nurse in an emergency department.

 Each result is aimed to refine the gain function which will be used to estimate the optimal
 dose for the next patient. The dose to be administered to the next patient will be determined
 by the Clinical Investigation Centre based on the data of the previous patient. It will be
 determined using a gain function whose objective is to represent the best compromise between
 efficacy and safety. It assigns a value to the patient representing the benefit: in case of
 toxicity this value will be 0; otherwise it will be equal to the decrease in PaCO2.

 Constant monitoring for up to 4 hours will be done as part of this study to detect the
 occurrence of adverse events. In particular, the following will be monitored: disturbances of
 consciousness, vomiting or secretions requiring airway protection; hemodynamic instability;
 restlessness and/or inability to keep the mask on. Therefore, ongoing monitoring for routine
 patient care may be extended at the discretion of the clinical physician in charge of the
 patient.

 Follow-up of patients will be done in 15 minutes, 1 hour, 4 hours (or NIV stop) and 24 hours.
 Clinical, paraclinical, biological parameters and the occurrence of adverse events will be
 performed in 15 minutes, 1 and 4 hours follow-up. During 24 hours only the occurrence of
 adverse event will be reported.

 The trial shall be concluded when the maximum number of patients is reached (N=24), or when a
 sufficiently accurate estimate of the dose maximizing the benefit-risk balance is obtained
 while remaining within the toxicity limit set at a 30% probability of DLT. The precision of
 this estimate will be measured by the ratio of the upper and lower bounds of the confidence
 interval. If this ratio is less than 5, the precision is considered to be sufficient to stop
 the study.

 Four groups of data will be collected at different times: biological parameter, clinical and
 paraclinical parameters as well adverse event.

 Clinical parameter: demographic variable (gender, age), weight, height, BMI, Richmond
 Agitation- Sedation Scale, Visual analog scale of dyspnea (Borg scale), numerical rating
 scale for pain assessment.

 Paraclinical parameter: Vital parameters: heart rate, respiratory rate, blood pressure,
 ventilatory rate, SpO2, NIV settings, EPAP, IPAP and Tidal Volume.

 Biological parameter: Blood count, arterial blood gas, chemistry panel.

 outcome measure: Optimal dose is defined as the dose associated with the maximum of gain
 function, used to determine the best compromise between efficacy and toxicity.

 It combines:

 1. The probability of dose - limiting toxicity (DTL), defined as the occurrence of one or
 more of the following criteria occurring within 4 hours of morphine administration:

 -  Respiratory Rate ≤ 10/min;

 -  Richmond Agitation-Sedation Scale (RASS) < -2

 -  Vomiting

 -  Naloxone administration.

 2. Efficacy and toxicity defined by:

 -  PaCO2 1 hour after morphine injection, according to the hormetic dose-response
 model ("J-curve": efficacy first increases with the dose, then reach a maximum and
 decreases in case of excessive bradypnea).

 Study design:

 Estimation of enrollment: Up to 24 participants. The calculation of the sample size was
 carried out by simulating several scenarios based on the prior to be used in the study. The
 simulated scenarios are as follows: one with low toxicity (5% at 0.02 mg/kg and 30% at 0.1
 mg/kg), one with high toxicity (10% at 0.02 mg/kg and 40% at 0.04 mg/kg) and one where the
 toxicity is identical to the prior.

 Simulation results showed a number of subjects required up to 24, with a median of 6 to 11,
 according to the scenario. The investigators therefore chose to define a maximum number of
 patients to 24, which is higher than the average of the worst-case scenario and corresponds
 to the maximum number of patients required among the 100 simulations of the worst-case
 scenario. However, it is very likely that the inclusions will be stopped earlier, when the
 accuracy is satisfactory.

 Analysis:

 The method used will be an adaptive Bayesian dose-finding procedure for a binary response
 (DLT), and a continuous response (PaCO2 used as a biomarker of efficacy and toxicity,
 following a hormetic response), using a gain function which objectively represent the
 compromise between efficiency and safety. The investigators will use a function already
 described in the literature .

 No interim analysis planned for this study.
Inclusion Criteria:

 -  Patients Aged ≥ 18 years

 -  Current or former smoker at least 10 packs-years

 -  At least one respiratory function test (EFR) with a FEV1/CVF ratio < 0.70
 post-bronchodilator.

 -  Acute exacerbation of COPD (greater degradation of respiratory symptoms than the usual
 daily variations and requiring a modification of therapeutic management)

 -  Need to implement NIV treatment (respiratory acidosis with pH<7.35)

 -  Ventilation frequency > 20min

 -  Affiliation to the French security system (or equivalent)

 -  Written informed consent from the patient or his surrogates. In patients who are not
 able to consent on admission an emergency inclusion procedure will be allowed, with a
 mandatory delayed consent.

 Exclusion Criteria:

 -  Patient already treated by NIV during admission (e. g. introduction in pre-hospital by
 SMUR)

 -  Sedative (barbiturates, benzodiazepines and related substances and other sedatives) or
 morphine treatment within 24 hours before inclusion

 -  Chronic alcoholism

 -  Contra-indication to NIV: disturbances of consciousness (Glasgow < 11) except moderate
 hypercapnic encephalopathy; indication of immediate intubation; risk of inhalation;
 sputum impossible; hemodynamic instability; inability to remove the mask; trauma,
 surgery or facial malformation; patients with pH < 7.25 can only be included in an
 intensive care environment.

 -  NIV with palliative purpose from the outset with death expected within 24 hours of
 inclusion

 -  Patients with Alzheimer disease or psychiatric disorders

 -  Contra-indication to morphine without acute respiratory distress

 -  Pregnant or breastfeeding women

 -  Major mentioned in Articles L1121-6 and 1121-8 of French public health cod

 -  Patients in a period of exclusion from other research involving the human person type
 1 or 2

 -  Subject cannot be contacted in case of emergency