Pilot Study of the Effect of Baclofen and Bromocriptine on Luteinizing Hormone Secretion in Pubertal Children
Pilot Study of the Effect of Baclofen and Bromocriptine on Luteinizing Hormone Secretion in Pubertal Children
OBJECTIVES: I. Evaluate the effect of bromocriptine on luteinizing hormone (LH) secretion by
 suppression of prolactin and stimulation of dopaminergic receptors in early pubertal boys and
 girls.

 II. Evaluate the effect of baclofen on LH secretion by stimulation of gamma-aminobutyric acid
 receptors in early pubertal boys and girls.
PROTOCOL OUTLINE:

 Participants receive bromocriptine or baclofen followed by nocturnal measurements of
 luteinizing hormone, growth hormone, and sex steroids. Pituitary reserve is evaluated with
 the administration of gonadotropin-releasing hormone, and in children undergoing assessment
 of short stature, standard provocative stimuli.
-  Short stature and/or constitutional growth delay

 -  No epilepsy or risk of epilepsy