Evaluation of Oral Tofacitinib in Children Aged 2 to 17 Years Old Suffering From Moderate to Severe Ulcerative Colitis
Evaluation of Oral Tofacitinib in Children Aged 2 to 17 Years Old Suffering From Moderate to Severe Ulcerative Colitis
This study, A3921210 is designed to evaluate the efficacy, safety and pharmacokinetics (PK)
 of tofacitinib in pediatric participants with moderately to severely active UC. In the US
 patients with prior TNFi failure or intolerance will be enrolled. Outside of the US, TNFi
 naïve and TNFi experienced patients will be enrolled.

 All eligible participants will initially receive open label tofacitinib at a dose expected to
 produce equivalent systemic exposure to that observed in adults receiving 5 mg BID with the
 option for individual dose increase to 10 mg BID adult dose equivalent if dose escalation
 criteria are met.

 The primary objective of this study is to evaluate the efficacy of tofacitinib based on
 remission in pediatric participants with moderately to severely active UC. The primary
 endpoint is remission by central read Mayo score following 44 weeks in the maintenance phase.
 Remission is defined by a Mayo score of 2 points or lower, with no individual subscore
 exceeding 1 point and a rectal bleeding subscore of 0.

 The study Design is an open-label Phase 3 study that includes a screening period of up to
 4-weeks duration, an 8-week or 16-week induction phase, a 44-week maintenance phase, and a
 24-month extension phase for pediatric participants with moderately to severely active UC.
 Participants will have a follow-up visit 4 weeks after the last dose of study intervention
 and a telephone contact 8 weeks later to assess for any adverse events (AEs)/serious adverse
 events (SAEs). The total maximum duration of this study will be up to 180 weeks.
Inclusion Criteria:

 -  Evidence of a personally signed and dated informed consent document and assent
 document.

 -  Males and females 2 to less than18 years old and weighing at least 10 kg.

 -  Having a pathology report that confirms colonic inflammation consistent with UC with a
 clinical diagnosis of UC for at least 12 weeks prior to baseline, with biopsy report
 supporting the diagnosis of UC.

 -  Participants diagnosed with UC at age less than 6 years old, must have had testing and
 be negative for monogenic disorders associated with very early onset IBD.

 -  Moderately to severely active UC as defined (via screening colonoscopy) by a Mayo
 score of at least 6, with a rectal bleeding score of at least 1 and an endoscopic
 subscore of at least 2.

 -  Pediatric Ulcerative Colitis Activity Index (PUCAI) score greater or equal to 35 .

 -  No history of dysplasia or colon cancer.

 -  No evidence or history of untreated or inadequately treated active or latent infection
 with Mycobacterium Tuberculosis.

 -  For participants outside of the United States: have had an inadequate response or been
 intolerant to at least one prior therapy as listed below or have a medical
 contraindication to such therapies:

 -  Oral or intravenous (IV) corticosteroids;

 -  Azathioprine or 6-mercaptopurine;

 -  TNF inhibitors or anti integrin therapy.

 -  For participants in the United States: have had an inadequate response or intolerance
 to TNF inhibitors.

 -  Stable doses of the following therapies for UC:

 -  Oral 5 Aminosalicyclic acids (ASA) or sulfasalazine

 -  Oral corticosteroids equivalent to prednisone at most 1 mg/kg up to a maximum of
 20 mg/day or budesonide up to 9 mg/day.

 -  evidence of prior varicella zoster virus exposure based on serological testing.

 -  female participant is eligible if she is not pregnant or breastfeeding, If she is a
 woman of child bearing potential, she needs to be using a contraceptive method that is
 highly effective (with a failure rate of <1% per year).

 Exclusion Criteria:

 -  Diagnosis of indeterminate colitis, isolated proctitis, microscopic colitis,
 infectious colitis, Crohn's disease, or clinical findings suggestive of Crohn's
 disease.

 -  History of symptomatic obstructive intestinal strictures or active ostomy, or history
 of colectomy, extensive small bowel resection ( greater than100 centimetres) or short
 bowel syndrome, or hospitalization for UC related reason(s) within 4 weeks of baseline
 visit.

 -  Any factors or clinical characteristics potentially related to the risk of venous
 thromboembolism that may increase the risk associated with study participation or
 study intervention administration or may interfere with the interpretation of study
 results and, in the judgment of the investigator, would make the participant
 inappropriate for entry into this study.

 -  Participants who have previously received tofacitinib or another Janus Kinase
 inhibitor.

 -  Vaccination or exposure to a live or attenuated vaccine within the 6 weeks prior to
 the first dose of study drug, or who are expected to be vaccinated or to have
 household exposure to these vaccines during treatment or during the 6 weeks following
 discontinuation of study drug.

 -  Participants having received azathioprine, 6-mercaptopurine, methotrexate,
 thioguanine, infliximab, adalimumab, golimumab, interferon, cyclosporine,
 mycophenolate, tacrolimus, IV or rectally administered corticosteroids, natalizumab,
 vedolizumab, other antiadhesion molecules, or investigational drugs during the
 specified time periods prior to baseline whereby they may still have pharmacokinetic
 and/or pharmacodynamic effect in the body of the participant.

 -  Previous treatment by leukocyte apheresis including selective lymphocyte, monocyte, or
 granulocyte apheresis, or plasma exchange within 6 months prior to baseline.

 -  Treatment by specified prohibited concomitant medications, including moderate to
 potent CYP3A inducers or inhibitors in the specified time periods prior to the first
 dose of study drug or are expected to receive any of these medications during the
 study period.

 -  Chronic and frequent use of antimotility agents for control of diarrhea (ie,
 diphenoxylate hydrochloride with atropine sulfate or loperamide).

 -  History of bowel surgery, including cholecystectomy within 6 months prior to baseline,
 history of appendectomy within 3 months prior to baseline, or significant trauma or
 major surgery within 4 weeks of screening visit are excluded.

 -  Participants with the following laboratory values at screening:

 -  Hemoglobin level lower than 9.0 g/Dl.

 -  Absolute white blood cell (WBC) count lower than 3000/mm3.

 -  Absolute neutrophil count lower than 1200/mm3.

 -  Absolute lymphocyte count lower than 750/mm3.

 -  Thrombocytopenia as defined by a platelet count lower than 100,000/mm3.

 -  Estimated bedside Schwartz Glomerular filtration rate (GFR) lower or equal to 40
 mL/min/1.73 m2.

 -  Total bilirubin, aspartate aminostransferase (AST) or alanine aminotransferase
 (ALT) more than 1.5 times the upper limit of normal.

 -  Positive stool examinations for enteric pathogens, pathogenic ova or parasites, or C.
 difficile toxin at screening.

 -  Participants infected with human immunodeficiency virus (HIV) or hepatitis B or C
 viruses.

 -  History of more than one episode of HZ, a history of disseminated HZ or disseminated
 herpes simplex.

 -  History or current symptoms of any lymphoproliferative disorder (eg, Epstein Barr
 Virus (EBV) related lymphoproliferative disorder, lymphoma, leukemia,
 myeloproliferative disorders, multiple myeloma, or signs and symptoms suggestive of
 currently lymphatic disease).

 -  Clinically significant infections currently or within 3 months prior to baseline (eg,
 those requiring hospitalization or parenteral antimicrobial therapy or opportunistic
 infections), a history of any infection requiring antimicrobial therapy within 2 weeks
 of baseline, or a history of any infection otherwise judged by the investigator to
 have the potential for exacerbation by participation in the study.

 -  Any malignancies or with a history of malignancies, with the exception of adequately
 treated or excised nonmetastatic basal cell or squamous cell cancer of the skin.

 -  Investigator site staff members directly involved in the conduct of the study and
 their family members, site staff members otherwise supervised by the investigator, or
 participants who are employees of the Sponsor, including their family members,
 directly involved in the conduct of the study.

 -  Participation in other studies involving investigational drug(s) within 2 months prior
 to study entry and/or during study participation.

 -  Other acute or chronic medical or psychiatric condition including recent (within the
 past year) or active suicidal ideation or behavior or laboratory abnormality that may
 increase the risk associated with study participation or study intervention
 administration or may interfere with the interpretation of study results and, in the
 judgment of the investigator, would make the participant inappropriate for entry into
 this study.

 -  Pregnant female participants; breastfeeding female participants; fertile female
 participants of childbearing potential who are unwilling or unable to use a highly
 effective method of contraception as outlined in this protocol for the duration of the
 study and through the telephone follow up visit.