The Compliance and Prognosis of NSBB Secondary Prevention of Cirrhosis With Gastroesophageal Varices Bleeding
The Compliance and Prognosis of NSBB Secondary Prevention of Cirrhosis With Gastroesophageal Varices Bleeding
Non-selective beta blockers are commonly used drugs for primary prevention and secondary
 prevention in patients with cirrhotic decompensated esophageal varices bleeding，the basic
 heart rate, blood pressure and condition of different patients have individual
 differences.This paper mainly discusses the compliance of patients taking NSBB under
 different follow-up methods and analyze the factors affecting patient compliance.
Esophagogastric variceal hemorrhage is a common complication of decompensated liver cirrhosis
 and the rate of rebleeding after hemostasis is high.Effective secondary prevention reduces
 the risk of rebleeding.Non-selective beta blockers are commonly used drugs for secondary
 prevention.Clinically, there is a great difference in the compliance of patients taking
 non-selective beta receptor blockers.In this study, the enrolled patients were divided into
 three groups: the traditional follow-up group (face-to-face interview);Non-traditional
 follow-up (WeChat, telephone, etc.);Traditional and non-traditional methods of follow-up were
 combined in the group.The investigators collected the basic data before the patients were
 enrolled, adjusted the medication dosage according to the patients' condition during the
 follow-up period, and recorded the treatment during the follow-up period, and analyzed the
 factors influencing the patients' compliance.
Inclusion Criteria:

 1. Signed informed consent

 2. All cases met the diagnostic criteria for cirrhosis

 3. All patients were confirmed to be combined with esophageal and gastric varices through
 endoscopy or portal vein CTA or abdominal CT, and had at least one history of
 esophageal and gastric varices rupture and bleeding. Child-pugh was graded as A/B.

 4. All patients had basal heart rate greater than 60 beats/min and systolic pressure
 greater than 90mmhg.

 Exclusion Criteria:

 1. Patients with liver cancer or other gastrointestinal tumors

 2. Patients with splenomegaly due to extrahepatic portal hypertension and noncirrhosis

 3. Patients with basal heart rate less than 55 beats/min or systolic pressure less than
 90mmhg

 4. There are patients with NSBB contraindications such as severe cardiac insufficiency,
 cardiogenic shock, sinus bradycardia and morbid sinus syndrome, severe ventricular
 conduction block, bronchial asthma, etc.

 5. Patients with other diseases other than liver cirrhosis should take beta blockers
 (such as coronary heart disease, arrhythmia, etc.).

 6. Patient data is incomplete, data cannot be collected and counted

 7. Patients who do not agree with secondary prevention after informing them about the
 adverse reactions associated with medication