The Effect of Ketogenic Dietary Therapy on Sleep in Adult Epilepsy
The Effect of Ketogenic Dietary Therapy on Sleep in Adult Epilepsy
The modified Atkins diet, a form of ketogenic therapy in which individuals severely restrict
 their carbohydrate intake and subsequently enter ketosis, has begun to be used as an
 adjunctive treatment in adults with intractable epilepsy who are not surgical candidates. In
 this study, the investigators examine the effect of ketogenic dietary therapy on sleep, as
 sleep deprivation is one of the most common seizure triggers and seizures themselves have
 been found to affect sleep quality. This pilot study will enroll twenty participants, ten of
 whom are initiating ketogenic dietary therapy and ten participants who are being treated with
 standard anti-seizure drug therapy.
Twenty participants, 10 participants on the modified Atkins diet and 10 control participants,
 will be enrolled in the study. All participants will fill out validated sleep questionnaires
 and complete sleep and seizure diaries. Furthermore, all participants will wear actigraphy
 watches prior to ketogenic dietary therapy initiation as well as four to six weeks after
 being on the diet. For control participants, the actigraphy will be completed at two time
 points to mimic that of the participants in the dietary therapy group. For the home sleep
 studies for the subset of participants, these will be completed at similar time intervals as
 that of the actigraphy. Adherence to the diet will be monitored according to standard medical
 management; for any participant on the diet, he or she will keep track of food intake and
 track ketones, which will be submitted at the four to six week follow-up visit.
Inclusion Criteria:

 -  Diagnosis of epilepsy

 -  Diet arm - participants who plan to newly initiate treatment with the Modified
 Atkins Diet (MAD) within the next 2 months as an adjunctive treatment for
 epilepsy

 -  Control arm - participants who do not plan to initiate ketogenic dietary therapy
 in the next 6 months

 Exclusion Criteria:

 -  Diagnosed sleep disorders (obstructive sleep apnea, primary insomnia, idiopathic
 hypersomnia, narcolepsy type I or II, REM sleep behavior disorder)

 -  Previously attempted dietary therapy for epilepsy who were not successful or compliant

 -  Anticipated need to adjust anti-seizure medications within the next 3 months

 -  Already on a ketogenic diet at the beginning of the study

 -  Planning to pursue surgical treatment for epilepsy in the next 6 months

 -  Non-English speakers

 -  Standard modified Atkins diet exclusion criteria (see below)

 -  At the discretion of the PI

 -  Live greater than 20 miles from the greater Madison area (in case there is a need to
 personally pick up the home sleep monitor at the participant's home)

 -  More than two no show appointments in the past 6 months

 For reference, the clinical exclusion criteria for the modified Atkins diet are listed
 here. These will have been verified clinically in order for the participant to be on the
 diet, and any reassessment of these criteria will be solely standard care, for clinical
 purposes:

 -  Unwilling to restrict carbohydrates

 -  Significantly underweight (BMI <18.5)

 -  Kidney disease

 -  Metabolic or mitochondrial disorder

 -  Pregnancy

 -  Aversion to liquids or inability to eat solid food

 -  At the discretion of the PI