Evaluation of Iron Supplementation During Darbepoetin Alfa Treatment in Prophylaxis of Severe Anaemia Chemo-Induced
Evaluation of Iron Supplementation During Darbepoetin Alfa Treatment in Prophylaxis of Severe Anaemia Chemo-Induced
The purpose of this study is to evaluate the response rate obtained in an heterogeneous
 oncologic population treated by chemotherapy, and either by Darbepoetin alfa classic
 treatment or by association of Darbepoetin alfa -ferric saccharose systematic
 supplementation, administered concomitantly with chemotherapy.
Inclusion Criteria:

 -  Age ≥ 18 years

 -  Well-informed written consent, signed by the patient

 -  Patient picked up for solid tumor treatment, whichever the localization, with or
 without metastasis

 -  Patient revealing, before or during chemotherapy, a moderate anemia, that means: Men:
 9<Hb<12 g/dl; Women: 9<Hb<11 g/dl.

 -  Patient for who at least four chemotherapy cycles are planed (eight in case of weekly
 chemotherapy) after inclusion in the study

 -  Patients with life expectancy higher than three months

 -  Patient with general conditions compatible with the study's follow-up

 Exclusion Criteria:

 -  Contra-indication for Venofer

 -  Anemia which can have curative treatment

 -  Bloody transfusion during the previous four weeks

 -  Documented or suspected medullary invasion

 -  Uncontrolled arterial hypertension

 -  Acute bacterial infection

 -  Transferrin saturation's coefficient

 -  Pregnancy

 -  Ferric salts oral treatment interrupted since less than one week

 -  Patient with bad french language's comprehension

 -  Patient with a major psychiatric pathology

 -  Patient under guardianship, trusteeship or justice safeguard