Prophylactic Continuous Positive Airway Pressure (CPAP) in Delivery Room, in the Prevention of Transient Tachypnea of Newborn (TTN): A Randomized Controlled Trial
Prophylactic Continuous Positive Airway Pressure (CPAP) in Delivery Room, in the Prevention of Transient Tachypnea of Newborn (TTN): A Randomized Controlled Trial
Transient Tachypnea of the Newborn (TTN) is a disorder of delayed clearance of lung liquid
 and a common cause of admission of full term infants and late pre term infants (34 to 36
 weeks) to Neonatal Intensive Care Units (NICU). Both late preterm gestational age at
 delivery, and mode of delivery are considered risk factors for TTN. The investigators
 hypothesize that CPAP administered prophylactically in the Delivery Room via a T piece based
 infant resuscitator Neopuff, to neonates at increased risk for TTN, would decrease the
 incidence of TTN and thus decrease the need for hospitalization in the NICU. This is a pilot
 study to evaluate the prophylactic administration of CPAP in the Delivery Room towards
 prevention of TTN and it's effects on natriuretic peptides.The study will be conducted as a
 randomized control trial after obtaining informed consents from the parents of eligible
 infants. Infants will be randomized to receive either experimental treatment (prophylactic
 CPAP) or standardized care.
Inclusion Criteria:

 -  Babies born to mothers via elective CS: elective CS defined as planned CS in the
 absence of Labor.

 -  Late preterm infants (34 1/7 to 36 6/7 weeks gestational age)

 Exclusion Criteria:

 -  Presence of any of the risk factors for neonatal sepsis such as Prolonged Rupture of
 Membranes for ≥18 hours (PROM), maternal fever, maternal chorioamnionitis or positive
 maternal GBS colonization

 -  Need for use of PPV for perinatal depression or other indications

 -  Presence of any of the following

 -  congenital malformations (diagnosed prenatally)

 -  chromosomal anomalies (diagnosed prenatally)

 -  congenital heart disease diagnosed by fetal echocardiography.