Association Between Metabolic Syndrome and Serum Nerve Growth Factor Levels in Women With Overactive Bladder
Association Between Metabolic Syndrome and Serum Nerve Growth Factor Levels in Women With Overactive Bladder
Nerve growth factor (NGF-R) receptors are between the detrusor muscle fibers and can cause
 afferent signals. Metabolic syndrome and obesity have been advocated to be risk factors for
 the development of overactive bladder.
Overactive bladder is a clinical syndrome characterized urgency, frequency and nocturia.
 Infection or other obvious causes must be excluded. The overactive bladder is loss of
 inhibition of the detrusor muscle during the filling or emptying of the bladder.

 Specific receptors and neurotransmitters have role in development of overactive bladder.
 These includes adrenergic, cholinergic, non-adrenergic, non-cholinergic receptors and
 interstitial cells.

 Nerve growth factor (NGF-R) receptors are between the detrusor muscle fibers and can cause
 afferent signals. Metabolic syndrome and obesity have been advocated to be risk factors for
 the development of overactive bladder. The investigators believe that our findings will shed
 light on treatment.
Inclusion Criteria:

 -  women with urgency, nocturia and frequency

 -  Abdominal obesity, defined as a waist circumference in men ≥88 cm

 -  Serum triglycerides ≥150 mg/dL (1.7 mmol/L) or drug treatment for elevated
 triglycerides

 -  Serum HDL cholesterol <40 mg/dL (1 mmol/L) in men and <50 mg/dL (1.3 mmol/L) in women
 or drug treatment for low HDL-C

 -  Blood pressure ≥130/85 mmHg or drug treatment for elevated blood pressure

 -  Fasting plasma glucose (FPG) ≥100 mg/dL (5.6 mmol/L) or drug treatment for elevated
 blood glucose

 Exclusion Criteria:

 -  Chronic obstructive pulmonary disease allergy

 -  Psychiatric disorders

 -  Urinary tract infection

 -  Neurological diseases

 -  Metabolic diseases

 -  Pure stress or mixed urinary incontinence

 -  History of pelvic surgery

 -  Diabetes mellitus