HIAS II - Study of Nutritional Supplementation in Hospitalized Children With Persistent Diarrhea or Malnutrition
HIAS II - Study of Nutritional Supplementation in Hospitalized Children With Persistent Diarrhea or Malnutrition
This study will determine the effect of 7 days supplementation of alanyl-glutatime or glycine
 on the damaged intestinal barrier function on day 8 in children with persistent diarrhea or
 malnutrition.
The purpose of this study is to determine the effect of 7 days supplementation of
 alanyl-glutamine or glycine on the damaged intestinal barrier function, measured by
 lactulose/mannitol test on day 8, in children with persistent diarrhea or malnutrition; on
 diarrhea frequency and duration, weight gain, protein loss, intestinal inflammation, and
 lactoferrin excretion.
Inclusion Criteria:

 1. Children ages 3 to 36 months with a history of persistent diarrhea (3 or more unformed
 stools/day) for >2 weeks or height-for-age Z-score (HAZ) less than negative 1, which
 is the median of HAZ score in children at HIAS.

 2. Be an inpatient and willing to stay for 7 nights at HIAS.

 3. Child´s parent or guardian must sign informed consent..

 Exclusion Criteria:

 1. Children exclusively breast-fed (Reason: The diet needs to be controlled in order to
 evaluate the study treatment effect)

 2. Children who participated in the community study or any other study within the past
 two years (Reason: The children in the community study will have received glutamine.)

 3. Children with suspected other illnesses as indicated by fever >102º F at time of
 screening off antipyretics

 4. Children with suspected systemic disease at the time of screening including but not
 limited to shock, meningitis, sepsis, pneumonia, tuberculosis, varicella

 5. Severe malnutrition defined as HAZ <-3 or WAZ <-3.5 or any child weighing <10 lbs.
 (4.5 kg) or any child with a weight-to-height ratio <60% of the NCHS age adjusted
 norm.