Alcohol Withdrawal Syndrome Treated With Adjunctive Phenobarbital or Ketamine
Alcohol Withdrawal Syndrome Treated With Adjunctive Phenobarbital or Ketamine
The goal of this study will aim to determine if adding phenobarbital or ketamine to a
 symptom-triggered benzodiazepine regimen decreases the rate of intensive care unit admissions
 during the treatment of alcohol withdrawal syndrome when compared to symptom-triggered
 benzodiazepine therapy alone.
The primary objective of this study is to compare phenobarbital and ketamine adjunctive
 therapies to lorazepam-based therapy in the treatment of acute alcohol withdrawal syndrome.

 It is hypothesized that the use of an alternative agent, either phenobarbital or ketamine,
 when used as an adjunct to symptom-triggered lorazepam therapy will significantly reduce the
 rate of intensive care unit admissions and thereby reduce the total cost associated with
 hospital admission for treatment of alcohol withdrawal syndrome.

 Enrolled patients will be admitted to Santa Barbara Cottage Hospital where they will be
 monitored with continuous pulse oximetry and cardiac telemetry. They will remain hospitalized
 while undergoing study-guided therapy in addition to supportive care for acute alcohol
 withdrawal syndrome. Patients will undergo standard of care therapy with lorazepam
 symptom-triggered therapy regardless of study participation.
Inclusion Criteria:

 -  Primary admitting diagnosis of acute alcohol withdrawal syndrome based on
 International Statistical Classification of Diseases and Related Health Problems 10th
 Revision (ICD-10), code F10.3, F10.4.

 Exclusion Criteria:

 -  Significant comorbid medical illness requiring Intensive Care Unit admission;

 -  Pregnancy;

 -  Inability to obtain intravenous access;

 -  Child Pugh Class C; and

 -  Allergy to study medications (phenobarbital, ketamine, lorazepam).