Brain Imaging in the Idiopathic REM Sleep Behavior Disorder (ALICE)
Brain Imaging in the Idiopathic REM Sleep Behavior Disorder (ALICE)
Idiopathic rapid eye movement sleep behavior disorder (iRBD) is characterized by nocturnal
 violence, increased muscle tone during REM sleep and the lack of any other neurological
 disease. However, iRBD can precede parkinsonism and dementia by several years. The causes of
 the loss of muscle atonia during REM sleep in these patients are unclear. Using 3 T MRI and
 neuromelanin- sensitive sequences, the signal intensity was previously found to be reduce in
 the locus coeruleus/subcoeruleus area of patients with Parkinson's disease and RBD. Here, the
 investigators aimed at studying the integrity of the locus coeruleus/ subcoeruleus complex
 with neuromelanin-sensitive imaging in 21 patients with iRBD and compared the results with
 those from 21 age- and gender-matched healthy volunteers. All subjects will undergo a
 clinical examination, motor, cognitive, autonomous, psychological, olfactory and color vision
 tests, and rapid eye movement sleep characterization using video-polysomnography and 3 T
 magnetic resonance imaging.
Inclusion Criteria:

 - idiopathic RBD (criteria of the international classification of sleep disorders-3)

 For healthy controls : no neurologic or psychiatric disorder

 Exclusion Criteria:

 -  Contraindication to MRI

 -  Do not speak French