Intact Liver Innervation and Glucose and Glucagon-like Peptide-1 (GLP-1) Induced Insulin Secretion
Intact Liver Innervation and Glucose and Glucagon-like Peptide-1 (GLP-1) Induced Insulin Secretion
The aim of the study is to investigate the significance of intact nerve supply to the liver
 for the glucagon-like peptide-1 (GLP-1) induced insulin secretion.

 The hypothesis is that the effects of GLP-1 is transmitted through the GLP-1 receptor and
 that these effects involve sensory afferent neurons, probably primarily parasympathetic.
GLP-1 is a potent enterogastron and incretin hormone. It is rapidly inactivated by dipeptidyl
 peptidase IV so only 10-15% enters the systemic circulation. This has led to the hypothesis
 that GLP-1 interact locally with afferent sensory nerve fibers.

 The aim of this study is to investigate the significance of intact liver innervation for the
 GLP-1 induced insulin secretion in liver transplanted patients; kidney transplanted control
 patients matched for immunosuppressive treatment, age, gender and body weight; and ten
 control persons matched for age, gender and body weight.

 The insulin secretion will be evaluated from blood samples that will be analyzed for insulin
 and c-peptide.
Inclusion Criteria:

 -  normal fasting plasma glucose

 -  normal hemoglobin

 -  informed consent

 Exclusion Criteria:

 -  type 1 diabetes mellitus or type 2 diabetes mellitus

 -  body mass index > 30

 -  inflammatory bowel disease

 -  intestinal surgery

 -  serum creatinine > 250 µM and/or albuminuria

 -  ALAT > 2 x normal value

 -  Severe cardiac insufficiency

 -  in treatment with medicine which cannot be paused for 12 hours