Study for the Effectiveness of Intensive Therapy Aiming at a Remission of Diabetic Nephropathy
Study for the Effectiveness of Intensive Therapy Aiming at a Remission of Diabetic Nephropathy
Study for the effectiveness of intensive therapy aiming at the remission of diabetic
 nephropathy
Study for the effectiveness of intensive therapy for diabetic nephropathy in unblinded,
 randomized intergroup comparison study.
Inclusion Criteria:

 1. Patients with type 2 diabetes

 2. Urinary albumin-to-creatinine ratio: >=300 mg/g creatinine twice in the first morning
 urine sample

 3. Serum creatinine level: =<2.5 mg/dl

 4. Patients aged 20-75 years

 Exclusion Criteria:

 1. Type 1 diabetes

 2. Hereditary diabetes or secondary diabetes

 3. Non-diabetic nephropathy

 4. Familial hypercholesterolemia

 5. Secondary hypertension

 6. Unstable angina pectoris or history of myocardial infarction/stroke within 6 months
 prior to consent acquisition

 7. Malignant tumor or life threatening disease

 8. History of angioedema

 9. Patients undergoing LDL apheresis

 10. Biliary system obstruction or severe liver injury

 11. Liver dysfunction

 12. Allergy for ACE-Is, ARBs or HMG-CoA reductase inhibitors

 13. Pregnant or nursing patients

 14. Others: patients who are not suitable for this trial