The Cardiopathic Features and Analysis of Risk Factors in the Elderly Diabetic
The Cardiopathic Features and Analysis of Risk Factors in the Elderly Diabetic
Objectives: To investigate the cardiac condition of the diabetic patients in our hospital in
 order to seek for the new diagnostic method of warning its cardiovascular complications in
 early times.

 Methods: 317 diabetic patients in our hospital from January in 2004 to July in 2008 were
 divided into 2 groups: group A (106 patients whose age ranged from (31-59) and group B (211
 patients whose age ranged from (60-90). The height, weight, blood glucose, glycosylated
 hemoglobin, lipid, blood pressure, course of disease, ejection fraction (EF), fractional
 shortening(FS), diameter of left ventricle in late diastolic stage(LVEDd), the thickness of
 the ventricular septa（IVSDand the posterior wall of the right ventricle in late diastolic
 stage (LVPWd)were recorded respectively. Left ventricular mass index (LVMI), relative wall
 thickness (RWT) were calculated and High-sensitive C-reactive protein (HsCRP), homocysteine
 and TNF-α were detected. Multifactor logistic regression was made based on the comparison and
 contrast between all indexes to analyze the correlations between age and the positive
 indexes.
Diabetes is one of the commonly seen health hazards in modern times. According to statistics,
 70% people with diabetes have died of cardiovascular diseases.

 Framingham 's study has proven the increase of the congestive heart-failure (2.4:1 in male
 patients and5:1 in female patients), which has no association with the age, hypertension,
 obesity, cardiovascular disease and Hyperlipidemia[1]. Other prospective studies also showed
 that the patients with diabetes in the early stage may be subject to abnormal echocardiogram
 and their probabilities of suffering from heart failure in the lifetime and Q-wave and non-Q
 wave myocardial infarction will be increased[1,2]. Early in 2000, American Heart Association
 issued a statement that "diabetes is a cardiovascular disease" [3]and in 2007, with reference
 to the joint guidelines concerning diabetes, pre-diabetes and cardiovascular disease,
 European Society of Cardiology (ESC) and the European Diabetes Research Institute (ESAD)
 clearly pointed out that hyperglycemia and cardiovascular disease (CVD) are closely related
 and the danger of CVD can be raised notably for those whose blood glucose is normal when
 fasting but tend to increase postprandially[4]. In the pathogenesis study of cardiovascular
 complications of diabetes, the promotion of oxidative stress and declination of the heart
 antioxidant reserves have close associations with the cardiovascular complications in animal
 and human body[5]. A number of cytokines and inflammatory signaling pathways are involved
 including tumor necrosis factor-α (TNF-α), high-sensitivity C-reactive protein (HsCRP),
 adiponectin, IL-6, NF-κB[1,6]. Accordingly, this study analyzes the echocardiography,
 high-sensitivity C-reactive protein and tumor necrosis factor-α of the patients with
 diabetics in our hospital in order to find early warning indicators of the cardiovascular
 complications of diabetes and provide prevention and treatment for cardiovascular
 complications of diabetes.
Inclusion Criteria:

 -  In-patient or out-patient patients diagnosed with diabetes

 -  Over 18 years of age

 -  Gender-open

 -  The type of diabetes (type 1 or type 2) open

 -  Patients receive a written informed consent to participate in the trial

 Exclusion Criteria:

 -  those diabetic patients with acute and chronic infection, high blood pressure, special
 and Gestational diabetes Serious complications of heart, liver, lung, kidney damage
 Malignant tumors

 -  Pregnant women and breast-feeding women