Transplantation of Cultured Gut Microflora to Repeat Antibiotic-induced Diarrhea Due to Clostridium Difficile
Transplantation of Cultured Gut Microflora to Repeat Antibiotic-induced Diarrhea Due to Clostridium Difficile
Patients who have received antibiotics and thereafter developed diarrhea are investigated for
 presence of Clostridium difficile toxin. Primary treatment is given with oral
 metronidazole/vancomycin. In case of relapse, secondary treatment is given with either
 cultured gut microbiota rectally or oral vancomycin in sequence. In those cases where
 secondary treatment with vancomycin fails cultured gut microbiota is given as final
 treatment. As an extension treatment, all failures were treated with cluttered gut microbiota
 through the upper route. In both cases As an alternative cultured gut microbiota may be given
 via the duodenal route. Follow-up is carried out after 7, 30 and 90 days with interview and
 stool collection for analysis of Clostridium difficile.
Inclusion Criteria:

 -  Antibiotic-induced diarrhea

 -  Positive fecal analysis for Clostridium difficile toxin

 Exclusion Criteria:

 -  Antibiotic treatment

 -  Probiotic treatment

 -  Intestinal infection other than Clostridium difficile

 -  Inflammatory bowel disease (Ulcerative colitis, Crohn's disease

 -  Immunodeficiency (drug- och disease-related)

 -  Pregnancy

 -  Unable to accept endoscopic procedures

 -  Unable to give informed consent