Effect of Aterial Stiffness on Myocardial Work in Patients With Hypertension
Effect of Aterial Stiffness on Myocardial Work in Patients With Hypertension
Hypertension is a serious threat to human health and a major global economic burden.Chronic
 hypertension can cause left ventricular remodeling and loss of function, eventually leading
 to heart failure.Exploring the early changes and mechanisms of left ventricular cardiac
 function caused by hypertension, and to identify individuals who may develop into serious
 heart injury, may play a positive role in the early prevention and control of heart failure
 caused by hypertension.Therefore, this study intend to use two-dimensional speckle tracking
 technology, a non-invasive method to measure left ventricular pressure-strain loop to
 quantitatively reflect cardiac work index , to study different hypertension patients with
 normal left ventricular ejection fraction the change of the global and local cardiac work,
 and the influence of aterosclerosis in thes patients to myocardial work, and explore their
 relationship with ventricular remodeling and abnormal diastolic function.To improve the
 understanding of the pathophysiology of hypertension, hypertensive heart disease and heart
 failure, and to provide scientific support for the early prevention and control of such
 diseases.
Hypertension is a serious threat to human health and a major global economic burden.Chronic
 hypertension can cause left ventricular remodeling and loss of function, eventually leading
 to heart failure. Ventricular remodeling in hypertensive patients is an adaptive and
 decompensating response to persistent elevated blood pressure and increased myocardial work
 load. Exploring the early changes and mechanisms of left ventricular cardiac function caused
 by hypertension, and to identify individuals who may develop into serious heart injury, may
 play a positive role in the early prevention and control of heart failure caused by
 hypertension.Therefore, this study intend to use two-dimensional speckle tracking technology,
 a non-invasive method to measure left ventricular pressure-strain loop to quantitatively
 reflect cardiac work index , to study different hypertension patients with normal left
 ventricular ejection fraction (including hypertension without heart damage performance with
 different degree of high blood pressure, hypertension with diastolic dysfunction ,
 hypertension with left ventricular hypertrophy ) the change of the global and local cardiac
 work, and the influence of aterosclerosis in thes patients to myocardial work, and explore
 their relationship with ventricular remodeling and abnormal diastolic function.To improve the
 understanding of the pathophysiology of hypertension, hypertensive heart disease and heart
 failure, and to provide scientific support for the early prevention and control of such
 diseases.
Inclusion Criteria:

 Age 18-65 years

 The diagnostic criteria of hypertension were blood pressure systolic blood pressure
 ≥140mmHg and/or diastolic blood pressure ≥90mmHg in the clinic or receiving
 antihypertensive drug treatment

 The normal high-value diagnostic criteria for hypertension were systolic blood pressure
 130-139mmhg and or diastolic blood pressure 85-90mmhg in the clinic

 LVEF > 50%

 Exclusion Criteria:

 coronary atherosclerotic heart disease or symptoms of angina

 Cardiomyopathy

 Valvular heart disease

 Diabetes

 Atrial fibrillation

 Renal function damage

 Pregnancy

 Secondary hypertension

 Chemotherapy for malignant tumors