Imaging Techniques in CT: Technical Development
Imaging Techniques in CT: Technical Development
Background:

 - Computed tomography (CT) scanning is a procedure that helps doctors with diagnoses. It uses
 X-ray radiation to produce an image in three dimensions. Researchers want to study how to get
 the best quality CT scans using the lowest possible radiation dose.

 Objective:

 - To determine how to improve CT scanning.

 Eligibility:

 - Adults 45 years of age and older who have not had a CT scan in the past year and do not
 have kidney disease.

 Design:

 -  Participants will be screened with a medical history and blood and urine tests.

 -  Nurses will put an intravenous (IV) line into an arm or hand vein. It will stay in for
 several hours during the magnetic resonance imaging (MRI) and CT scans. Through this IV,
 blood will be taken, dye will be injected, and medicine will be given.

 -  Participants may have a CT scan of the heart, head, chest, abdomen, and/or pelvis.
 Participants will lie on their back on a table. The table will slide into a donut-shaped
 machine. An X-ray tube will move around the body, taking pictures.

 -  Participants may be given a drug called a beta blocker by mouth or through the IV tube.

 -  Participants heart rate and blood pressure will be monitored.

 -  Participants may have an MRI scan. The MRI is a large hollow tube. The participant will
 lie on a table that will be moved into the tube, which contains a magnetic field. When
 the imaging starts, a thumping sound will be heard. Headphones or earplugs will be
 provided to muffle the sound.

 -  Participants will give blood samples.
In this protocol, computed tomography (CT) imaging performed on healthy volunteers and
 subjects with disease will be used to test, develop and optimize CT protocols. The results of
 this optimization will be used to evaluate the performance of new imaging methods and
 equipment, and to provide essential ground work for research and development for use in
 future patient CT studies. CT imaging is a noninvasive technology. As appropriate, MRI scans
 will be used to compare to CT imaging findings to help validate the CT methods.
-  INCLUSION CRITERIA:

 -  For new or healthy volunteers currently participating in an NIH trial: no CT scan in
 the last year OR For patients enrolled in a treatment or interventional trial at the
 NIH: no CT scan in the last 6 months

 -  Lab Eligibility parameters:

 -  For CT and MRI contrast enhanced scans:

 ---eGFR greater than or equal to 60 mL/min/1.73m(2) within 7 days prior to
 scanning

 -  For female participants ages 45-60 within 3 days prior to scan (unless
 post-menopausal or no longer able to bear children, note exemption on initial
 visit):

 -  Pregnancy test result(blood or urine): Negative

 -  Willing to travel to the NIH for follow-up visits.

 -  Greater than or equal to 45 years old

 -  Able to understand and sign informed consent

 -  Stable clinical status

 -  Volunteer indicates no history of participation in NIH protocols using research
 radiation in the last 12 months (e.g. PET research scans, NCI Molecular Imaging Center
 PET scans, etc)

 EXCLUSION CRITERIA:

 -  Prior CT scan in the last 12 months for new volunteers or healthy volunteers enrolled
 in NIH trials OR Prior CT scan in the last 6 months for patients enrolled in a
 treatment or interventional trial

 -  Pregnant women

 -  Over 500 lbs and/or a body circumference that prevents the study subject from lying
 flat in the scanner

 -  Claustrophobia requiring sedation or anesthesia.

 -  Known or suspected genetic predisposition to cancer

 -  Any contraindications that the research team identifies from the subject, radiology
 department CT and/or MRI questionnaires, and/or History and Assessment.

 Exclusion for participation for iodinated contrast for CT

 (Inclusive of the above exclusion criteria):

 -  Allergy to iodinated contrast for scans (study subject will be eligible for
 non-contrast scans)

 -  Acute renal failure, renal transplant, dialysis and renal failure (clinically
 diagnosed).<TAB>

 -  Lactating women

 -  Patient preference to not undergo intravenous line placement and/or receive iodinated
 contrast. Contrast administration is optional and participants may still undergo a
 non-contrast study.

 -  Use of metformin-containing products less than 24 hours prior To CT contrast
 administration

 -  Other contraindications to iodinated contrast media as determined by the research
 team.

 Exclusion for participation for Gadolinium contrast for MRI

 (Inclusive of the above exclusion criteria):

 -  Allergy to gadolinium for scans using contrast; will be eligible for non-contrast
 scans.

 -  Acute renal failure, renal transplant, dialysis and renal failure individuals ( Lab
 Eligibility parameters and/or clinically diagnosed).<TAB>

 -  Lactating women

 -  Patient preference to not undergo intravenous line placement and/or receive gadolinium
 contrast. Contrast administration is optional and participants may still undergo a
 non-contrast study.

 -  Other contraindications to gadolinium contrast media as determined by the research
 team.