A Pilot Study - Safety and Efficacy of Nailprotex® for Onychomycosis Treatment
A Pilot Study - Safety and Efficacy of Nailprotex® for Onychomycosis Treatment
This study was designed to demonstrate the efficacy of this product in non-dermatophyte
 (Scytalidium dimidiatum) onychomycosis and chronic paronychia treatment in Thai patients.
Onychomycosis is the common superficial fungal skin infection in general population.
 According to the previous study, the prevalence of tinea pedis and onychomycosis in general
 Thai population were 3.8% and 1.7% respectively. However, this problem has been neglected for
 treatment due to asymptomatic clinical manifestations and low effects in quality of life.

 In Thailand, the previous studies reported that the aetiological pathogens of this disorder
 were non-dermatophyte mold (51.6%), dermatophyte (36.3%) and yeast (6%). Additionally,
 Scytalidium dimidiatum was the majority causative agents in non-dermatophyte mold.

 Systemic therapy such as azoles group and terbinafine is recommended for the standard
 management of tinea capitis. In contrast, a prolonged course may be induce serious side
 effects. So that topical therapy is the alternative treatment in older patients who are
 limited in drug usage. Especially, non-dermatophyte onychomycosis is the recalcitrant
 condition. Moreover, none of the standard regimen is recommended.

 Nailprotex® is the novel topical treatment in onychomycosis and chronic paronychia. The
 active ingredient is phenol which is extracted from Olea European leaf. It is able to inhibit
 the fungal growth. Additionally, this product has been applied for nail care in many European
 countries over 10 years. The serious side effects have never been reported. Therefore, this
 study was designed to demonstrate the efficacy of this product in non-dermatophyte
 (Scytalidium dimidiatum) onychomycosis and chronic paronychia treatment in Thai patients.
Inclusion Criteria:

 -  Male or female participants was 18 years old or above.

 -  Participants were diagnosed Scytalidium dimidiatum onychomycosis or chronic paronychia
 by dermatologists based on clinical presentation and mycological identification.

 -  Participants accept the aim of this project and sign the consent form by themselves.

 Exclusion Criteria:

 -  Participants have other nail disorders before participate the research.

 -  Participants have the history of immunocompromised host.

 -  Participants were diagnosed onychomycosis more than 3 nails or matrix involvement.