Specific Carbohydrate Diet for Clostridium Difficile
Specific Carbohydrate Diet for Clostridium Difficile
The investigators are doing this research study to answer questions about a nutritional
 therapy called the Specific Carbohydrate Diet (SCD) for children with active Clostridium
 Difficile Infection.

 For this study, the investigators will be looking to determine:

 1. Is SCD effective for the treatment for Clostridium Difficile Colonization?

 2. Is the SCD well tolerated?
The aim of this study is to determine the tolerability and potential efficacy of dietary
 therapy, the Specific Carbohydrate Diet (SCD), in pediatric patients with persistent antigen
 positivity due to C. difficile colonization with minimally active symptomatology. The goal of
 this pilot study is to gather preliminary data for a future treatment controlled trial of SCD
 versus standard medical therapy.

 This is a single center, open labelled study designed to determine tolerability, preliminary
 safety and potential efficacy in pediatric patients with persistent C. difficile colonization
 with minimally active symptomatology. The study patients will be recruited from Seattle
 Children's Gastroenterology and Infectious Disease clinic.
Inclusion Criteria:

 1. Children and adolescents eighteen months old to twenty one years old

 2. Diagnosis of C. difficile based upon stool antigen and toxin

 3. Minimally active symptomatology based upon

 1. 4 or less stools per day

 2. No evidence of dehydration

 3. No evidence of bandemia or hypoalbuminemia on screening labs

 4. Parent/guardian and child must be able to comprehend the consent and assent

 5. Parent/guardian and participant must be able to attend study visits at baseline, and
 weeks +2, +4, +8, +12.

 6. Patient must not have had antibiotic treatment directed at C. difficile for at least 1
 week.

 Exclusion Criteria:

 1. Severe symptoms

 1. Abdominal pain that interrupts or inhibits normal activity

 2. Fever

 3. Vomiting

 4. Blood in stool

 2. Clinical signs of coexisting acute systemic illnesses (meningitis, sepsis, pneumonia),
 immunodeficiency, underlying severe chronic diseases, and cystic fibrosis

 3. Tobacco, alcohol or illicit drug abuse

 4. Currently taking antibiotics at time of enrollment

 5. Malnutrition as judged by the ratio of weight to height,

 6. Clinical signs of dehydration(CD score>0)