Comparing the Rate of Insufficient Cells for Diagnosis Between Surepath® and Conventional Smear in Women After Radiation Therapy for Cervical Cancer
Comparing the Rate of Insufficient Cells for Diagnosis Between Surepath® and Conventional Smear in Women After Radiation Therapy for Cervical Cancer
Background/Purpose: This is a large scale, multicenter randomized clinical trial to assess
 the feasibility of using SurePath® in cervical cancer patients after radiation therapy by
 comparing the incidence of unsatisfactory smear and the accuracy of detecting cervicovaginal
 lesions between the SurePath® and the conventional smear.

 Patients and Methods: The investigators will invite all women who had received radiotherapy
 for cervical cancer in the investigators outpatient clinics. All enrolled cases will ask to
 receive randomly the SurePath® or the conventional smear.

 Expected Results: The investigators will get the incidence of unsatisfactory smear and the
 accuracy of detecting cervicovaginal lesions between the SurePath® and the conventional smear
 in patients who underwent radiotherapy.
Adequate specimen (specimen adequacy) is cervical or vaginal cytology single most important
 quality factors. 2001 Pap Bethesda System classification maintain its previous version, the
 Pap specimen is divided into satisfactory assessment and unsatisfactory evaluation two kinds;
 meet "satisfactory assessments "specimen standard, conventional Pap (conventional smear)
 requires at least 8,000-12,000-readable squamous cells, and liquid-based Pap (liquid-based
 smear) you need at least 5,000-readable squamous cell .

 For squamous cell samples were determined to be adequate, yet to record their specimens have
 intrauterine neck or squamous transitional zone (transformation zone) border zone cells
 exist; quality indicators "Cell interpretation in part by inflammation or blood masking noise
 "of the specimen, if it can not be sentenced to 50-75% of epithelial cells can still be
 classified as read" satisfied "with the specimen, while more than 75% of the epithelial cells
 are obscured interference specimen is classified in the" unsatisfactory "specimen.
Inclusion Criteria:

 1. All women who had received radiotherapy for cervical cancer in our outpatient clinics.

 2. Prior to joining test subjects for 90 days or more earlier had received a complete
 pelvic radiation therapy, including treatment of the cervix or vagina.

 3. Subjects with radiation therapy (including combined chemical and radiation therapy or
 postoperative adjuvant [chemical] radiation therapy) for their first treatment.

 Exclusion Criteria:

 1. recurrence of cervical cancer

 2. hormone treatment within 90 days

 3. vaginal vault or cervix topical treatment within 90 days.

 4. Subjects had or now have other malignancies