How Side Effects of Avonex Are Affected by Gradually Increasing to Full Dose vs Starting at Full Dose
How Side Effects of Avonex Are Affected by Gradually Increasing to Full Dose vs Starting at Full Dose
This study is to find out if starting at low dose Avonex and slowly increasing to full dose
 will improve flu like symptoms as a side effect of Avonex treatment.
Inclusion Criteria:

 -  Diagnosis of clinically-definite relapsing-remitting multiple sclerosis

 Exclusion Criteria:

 -  Any Product Information-specified contraindications to interferon-beta therapy, or
 other medical factors which, in the opinion of the investigator, make the subject
 unsuitable for interferon-beta therapy

 -  Use of AVONEX, but not other interferon therapies, in the 3 months prior to
 randomisation into the study

 -  A clinically significant infectious illness (e.g., cellulitis, abscess, pneumonia,
 septicemia) within 30 days prior to randomisation.

 -  History of seizure in the 3 months prior to randomisation

 -  History of suicidal ideation or severe depression within the 3 months prior to
 randomisation.

 -  Other inclusion and exclusion criteria may apply per study protocol