Physiological Effects of Altering Cancer-related Inflammation
Physiological Effects of Altering Cancer-related Inflammation
This prospective pilot study will examine whether the previously reported effects of NSAIDs
 on colorectal cancer may be modulated through alterations in tissue gene expression, up
 regulation of local immune cell infiltrates or down-regulation of the systemic inflammatory
 response.
Bowel cancer is the second commonest cause of death from cancer in the UK. Of patients who
 have an apparently curative operation, half unfortunately suffer disease recurrence and die
 before 5 years. Clearly more research is required to improve outcomes in this condition. Most
 current research focuses on antitumour strategies, however the reaction of the patient (host)
 to the tumour is also important. The host inflammatory responses to the cancer are likely to
 represent part of this host-tumour relationship. Inflammation plays an important role in
 predicting patients who will die. Currently it is not known whether antiinflammatory drugs
 have any effect on cancer related inflammation detected in the blood or in/around the tumour.

 Aims: We hope to demonstrate that tumour related inflammation in bowel cancer can be altered
 using anti- inflammatory drugs. This may form the rationale for the use of antiinflammatory
 drugs to improve prognosis in colorectal cancer patients undergoing surgery.

 Methods: This pilot study will investigate whether simple antiinflammatory drugs can alter
 markers of inflammation both in the blood and in/around the tumour. Patients having bowel
 cancer surgery will be prescribed one of two anti-inflammatory drugs (aspirin 75mg once daily
 or ibuprofen 400mg three times daily) for 2 to 3 weeks prior to their operation. Blood and
 tumour samples before and after the treatment will be analysed.

 If the study's aims are met and cancer-related inflammation can be altered prior to surgery,
 then a larger scale drug trial will be proposed to demonstrate reduced cancer recurrence and
 improved survival.
Inclusion Criteria:

 -  aged 18 to 75 years old

 -  histologically confirmed colon cancer

 -  evidence of systemic inflammation (C-reactive protein >10mg/l)

 -  candidate for elective primary curative resection

 Exclusion Criteria:

 -  Age <18yrs or >75yrs

 -  emergency presentation

 -  rectal cancer

 -  distal metastatic disease at presentation

 -  provision of neo-adjuvant chemo-radiotherapy

 -  long-term use of aspirin or anti-inflammatory medications (NSAIDS, or steroids

 -  hypersensitivity to product or excipients or evidence of previous hypersensitivity
 reactions such as asthma, rhinitis, angioedema or urticaria in response to aspirin,
 ibuprofen or other NSAID

 -  intolerance of NSAIDs/ aspirin due to allergy or side effects

 -  active peptic ulcer disease

 -  previous history of recurrent gastrointestinal bleeding or bleeding/perforation
 secondary to previous NSAID use

 -  previous treatment for gastrointestinal cancer

 -  alcohol excess (above recommended guidelines)

 -  chronic renal impairment

 -  moderate to severe heart failure

 -  hepatic impairment