Prevention of Narcotic-Induced Nausea
Prevention of Narcotic-Induced Nausea
We are doing this study to find out if extra medicine is needed to avoid the chance of nausea
 sometimes linked to narcotic pain medicine (for example, morphine, dilaudid, fentanyl). Some
 doctors always give medicine to prevent the possible side effect of nausea, while others do
 not. We are looking to see if this extra medicine is helpful in preventing nausea. The goal
 is to screen all patients with pain and enroll enough subjects to reach our goal of 164
 evaluable study participants.
Patients will be randomized to one of two study groups. They will then be asked to rate their
 pain and nausea on a line graph. If the patient is a female of child bearing age, a urine
 pregnancy test will be done per standard of care. After this, an IV catheter will be placed
 in a vein in the patients arm. Pain medicine will be given through this IV per the doctor's
 order. With this medicine, patients will be given 10 milliliters (2 teaspoons) of either
 Sodium Chloride (salt water) or Phenergan mixed with Sodium Chloride (salt water). Phenergan
 is a medication typically used to help with nausea and is a common ingredient in prescription
 cough medicine.

 After this is finished, patients will be asked to rate their pain and nausea in 30 minutes,
 and again 1, 2, and 4 hours later. If the doctor decides the patient is able to be discharged
 from the emergency room before the 4 hours are up, they will be asked to rate your pain and
 nausea again before going home, and the study will be stopped at that time.
Inclusion Criteria:

 1. Patient in Christian Care Emergency Department

 2. Require intravenous narcotics for painful condition

 3. ≥18 years of age

 4. Able to visually rate amount of pain and nausea

 Exclusion Criteria:

 1. Hypersensitivity to promethazine or opioids

 2. Patient requesting anti-emetic at enrollment

 3. Narcotic administration in last 6 hours

 4. Pregnancy or currently breast-feeding

 5. Known seizure disorder

 6. Medical Instability