Whole Breast Irradiation vs Twice Daily vs. Once Daily Accelerated Partial Breast Irradiation
Whole Breast Irradiation vs Twice Daily vs. Once Daily Accelerated Partial Breast Irradiation
This is a randomized phase III trial in women with invasive carcinoma of the breast with
 negative axillary nodes treated by Breast Conserving Surgery (BCS). Eligible, patients will
 be randomly allocated to receive radiotherapy of 3 Dimensional Conformal Radiation Therapy
 (3DCRT) Whole Breast Irradiation (WBI) 50 Gray (Gy) in 25 daily fractions over 5 weeks or
 Accelerated Partial Breast Irradiation (APBI) 38.5 Gy in 10 daily fractions of 3.85Gy over
 two weeks or 38.5 Gy in 10 twice daily fractions of 3.85Gy over one week. Patients will be
 followed at 6, 12, 18 and 24 months post randomization. Cosmetic outcome will be measured
 using photographs and evaluated by a panel of trained radiation oncologists. Radiation
 toxicity will be assessed using National Cancer Institute Common Terminology Criteria for
 Adverse Events (NCI-CTCAE).
Women with invasive carcinoma of the breast less than 3 cm with negative axillary nodes ,
 following BCS, who meet the inclusion criteria will be approached for potential study
 enrollment.

 Eligible, consenting patients will be randomly allocated to receive radiotherapy of 3DCRT WBI
 50 Gy in 25 fractions over 5 weeks or APBI 38.5 Gy in 10 once daily fractions of 3.85Gy over
 two weeks or 38.5 Gy in 10 twice daily fractions of 3.85 Gy over one week. Patients will be
 followed at 6, 12, 18 and 24 months post randomization. Cosmetic outcome will be measured
 using photographs and evaluated by a panel of trained radiation oncologists using the EORTC
 Breast Cosmetic Rating System. Radiation toxicity will be assessed using the NCI CTCAE
 version 4.0. The primary outcome is to compare the acute, late toxicities and adverse
 cosmetic outcomes at 6, 12 and 18 months among the three groups.
Inclusion Criteria:

 Tumor characteristics

 -  Histologically confirmed invasive adenocarcinoma of the breast

 -  Tumors must be ≤ 3 cm. Gross disease must be unifocal. Negative lymph nodes

 -  Hormone receptor status:

 Estrogen receptor (ER) status known Progesterone status known if ER analysis is negative
 Marginal or borderline results are considered positive Surgery

 -  Tumor removed with conservative breast surgery with adequate margin

 -  Re-excision of surgical margins allowed

 -  No prior breast implants

 -  Prior axillary staging required for patients including 1 of the following:

 -  Sentinel node biopsy alone (if sentinel node is negative)

 -  Sentinel node biopsy followed by axillary dissection if sentinel node is
 positive)

 -  Axillary dissection alone with ≥ 6 axillary nodes

 -  Target lumpectomy cavity clearly delineated AND target lumpectomy/whole breast
 reference volume ≤ 30% based on postoperative pre-randomization CT scan

 -  Final surgery (i.e., lumpectomy, re-excision of margins, or axillary staging
 procedure) within the past 42 days

 -  No prior biologic therapy for this malignancy Chemotherapy

 -  No prior chemotherapy for this malignancy

 -  No concurrent chemotherapy during study radiotherapy Endocrine therapy

 -  No prior hormonal therapy for this malignancy

 -  Concurrent hormonal therapy allowed provided it is not administered during
 chemotherapy

 -  No concurrent raloxifene, tamoxifen, or other selective estrogen receptor modulating
 drugs

 -  No concurrent hormone replacement therapy Radiotherapy

 -  No prior radiotherapy for this malignancy

 -  No prior breast or thoracic radiotherapy

 -  No concurrent regional nodal irradiation Other

 -  No other concurrent anticancer therapy Menopausal status

 -  Premenopausal or postmenopausal Performance status

 -  WHO 0-1 Other

 -  Not pregnant or nursing

 -  Negative pregnancy test

 -  Fertile patients must use effective non-hormonal contraception

 Exclusion Criteria:

 -  Multicentric carcinoma in more than 1 quadrant or separated by ≥ 4 cm.

 -  Non-epithelial breast malignancies (e.g., sarcoma or lymphoma).

 -  Positive axillary nodes.

 -  Palpable or radiographically suspicious ipsilateral or contralateral axillary,
 supraclavicular, infraclavicular, or internal mammary nodes unless there is histologic
 confirmation that these nodes are negative for tumor.

 -  Suspicious microcalcifications, densities, or palpable abnormalities in the
 ipsilateral or contralateral breast unless biopsied and found to be benign

 -  Paget's disease of the nipple

 -  Previous history of invasive breast cancer or DCIS.

 -  Synchronous bilateral invasive or non-invasive breast cancer

 -  Collagen vascular disease (e.g., systemic lupus erythematosus or scleroderma),
 specifically dermatomyositis with a CPK level above normal, or active skin rash

 -  Psychiatric or addictive disorder that would preclude study therapy