The Effect of Rituximab on Mobilization With AMD3100 (Plerixafor) Plus G-CSF in Patients With Relapsed or Refractory Non-Hodgkin Lymphoma (NHL) or Hodgkin Disease (HD)
The Effect of Rituximab on Mobilization With AMD3100 (Plerixafor) Plus G-CSF in Patients With Relapsed or Refractory Non-Hodgkin Lymphoma (NHL) or Hodgkin Disease (HD)
Participants with non-Hodgkin lymphoma (NHL) or Hodgkin disease (HD) will be assigned to one
 of 2 arms based on the immunophenotype of their lymphoma.

 (A)Participants with CD20(-) lymphoma will undergo mobilization with granulocyte
 colony-stimulating factor (G-CSF) and plerixafor.

 (B) Participants with CD20(+) lymphomas will undergo mobilization with rituximab, G-CSF, and
 plerixafor. They will receive a weekly dose of rituximab beginning 1 week prior to, and
 continuing until 2 weeks after, the first dose of G-CSF.

 Participants in both groups will receive G-CSF twice daily for 4 days. In the evening on Day
 4, a dose of plerixafor will be administered. Apheresis will be initiated the next morning.
 Participants will continue to receive G-CSF twice daily and to receive the evening dose of
 plerixafor followed by apheresis the next morning for up to a total of 4 aphereses or until
 ≥5*10^6 CD34+ cells/kg are collected.

 Participants who are transplanted will be monitored for the time to polymorphonuclear
 leukocytes (PMN), platelets (PLT), and lymphocyte engraftment. Follow-up assessments will be
 done at 100 days, and 6 and 12 months post-transplantation.
This is a single-center, 2-arm, non-randomized, open-label study to evaluate the safety of
 plerixafor when used in combination with rituximab (Rituxan®) and granulocyte
 colony-stimulating factor (G-CSF) in patients with relapsed or refractory Hodgkin disease
 (HD) or non-Hodgkin lymphoma (NHL).

 Participants will be assigned to one of 2 arms based on the immunophenotype of their
 lymphoma.

 (A)Participants with CD20(-) lymphoma will undergo mobilization with G-CSF and plerixafor.

 (B) Participants with CD20(+) lymphomas will undergo mobilization with rituximab, G-CSF, and
 plerixafor. They will receive a weekly dose of 375 mg/m2 rituximab by intravenous (iv)
 infusion beginning 1 week prior to, and continuing until 2 weeks after, the first dose of
 G-CSF.

 Participants in both groups will receive 7.5 µg/kg G-CSF twice daily (morning and evening)
 for 4 days. In the evening (approximately 10:00 pm) on Day 4, a dose of plerixafor (240
 µg/kg) will be administered. Apheresis will be initiated the next morning, approximately 10
 to 11 hours after plerixafor is given. Participants will continue to receive G-CSF twice
 daily and to receive the evening dose of plerixafor followed by apheresis the next morning
 for up to a total of 4 aphereses or until ≥5*10^6 CD34+ cells/kg are collected.

 Participants with an adequate number of autologous peripheral blood stem cells (PBSCs)
 collected by apheresis will be admitted to the study center for the administration of
 high-dose chemotherapy and autologous transplantation. After transplantation, the times to
 PMN, PLT, and lymphocyte engraftment will be measured. Participants will remain hospitalized
 until they achieve an absolute granulocyte count of >500/µl in the peripheral blood. Graft
 durability will be assessed at 100 days, and 6 and 12 months post-transplantation.

 This study was previously posted by AnorMED, Inc. In November 2006, AnorMED, Inc. was
 acquired by Genzyme Corporation. Genzyme Corporation is the sponsor of the trial.
Inclusion Criteria (abbreviated list):

 -  Histological diagnosis of diffuse large cell lymphoma, B-cell, T-cell or anaplastic
 histologies; peripheral T-cell lymphoma; small non-cleaved Burkitt-like lymphoma; or
 Hodgkin disease. NOTE: Participants diagnosed at a facility outside of Emory
 University will have their diagnosis confirmed by Emory University pathologists prior
 to being enrolled in this study.

 -  Eligible for autologous transplantation.

 -  History of relapse of lymphoma following initial treatment with an
 anthracycline-containing regimen or disease that is refractory or progresses during
 initial therapy with an anthracycline-containing regimen.

 -  Immunophenotyping of the lymphoma at the time of diagnosis or relapse using flow
 cytometry or immunohistochemistry.

 -  Presence of clinically- and/or radiologically-documented, measurable, and/or evaluable
 disease at the time of relapse.

 -  Received 2 cycles of salvage chemotherapy.

 -  Complete response (i.e., normal physical examination, lymph nodes, lymph node masses,
 and bone marrow) or a partial response (i.e., decrease of ≧50% in the size of lymph
 nodes or lymph node masses or decrease in size of liver/spleen on physical exam) to at
 least one cycle of a salvage chemotherapy regimen.

 -  Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2.

 -  Absolute granulocytes count ≧1.0*10^9/l.

 -  Platelet count ≧75*10^9/l.

 -  Aspartate aminotransferase (AST) or alanine transaminase (ALT) ≦2.5 times the upper
 limit of normal (ULN) or ≦5 times the ULN if liver involvement with lymphoma.

 -  Life expectancy of at least 3 months.

 -  >4 weeks since last cycle of chemotherapy.

 -  Patient has recovered from all acute toxic effects of prior chemotherapy.

 -  Signed informed consent.

 Exclusion Criteria (abbreviated list):

 -  A second active malignancy (other than basal cell carcinoma of the skin).

 -  Uncontrolled central nervous system involvement by lymphoma.

 -  Positive/history of retroviral infection (HIV, HTLV-1).

 -  Active infection requiring antibiotics during planned lymphoma-related therapy.

 -  Previous treatment with high-dose chemotherapy or cytokine mobilization and
 hematopoietic progenitor cell transplantation.

 -  Continued evidence by morphology and flow cytometry of bone marrow involvement after
 at least one cycle of salvage chemotherapy.

 -  ≥3 cycles of salvage chemotherapy following documentation of lymphoma relapse or
 disease progression.

 -  (In patients with CD20(+) lymphoma) History of severe hypersensitivity reactions to
 rituximab.

 -  Positive pregnancy test in female patients.

 -  Lactating female patients.

 -  Previously received experimental therapy within 4 weeks of enrolling in this protocol
 or currently enrolled in another experimental protocol during G-CSF Mobilization
 Phase.

 -  Creatinine >1.5 times the ULN.

 -  Bilirubin >1.5 times the ULN.

 -  Ejection fraction <45%.

 -  Diffusion capacity of the lung for carbon monoxide (DLCO) <50%.

 -  Patients of childbearing potential unwilling to implement adequate birth control.

 -  A co-morbid condition that renders the patient at high risk from treatment
 complications.

 -  Residual acute medical condition resulting from prior chemotherapy.

 -  Documented history of ventricular arrhythmias during the last 3 years.

 -  Fever (temperature >38 °C/100.4 °F).

 -  Actual body weight exceeds 175% of ideal body weight.

 -  Participants who have deterioration of their clinical status or laboratory parameters
 between the time of enrolment and transplant (such that they no longer meet entry
 criteria) may be removed from study at the discretion of the treating physician,
 principal investigator, or sponsor.