Blood Markers Predict Effect of Normobaric Hypoxia at Rest and During Exercise in Patients With Pulmonary Hypertension
Blood Markers Predict Effect of Normobaric Hypoxia at Rest and During Exercise in Patients With Pulmonary Hypertension
To study the effect of acute normobaric hypoxia during exercise in patients with pulmonary
 hypertension on blood markers (serum markers of iron and red blood cell homeostasis and
 micro-RNAs known to be associated with PH).
Inclusion Criteria:

 -  Informed consent as documented by signature (Appendix Informed Consent Form)

 -  PH class I (PAH) or IV (CTEPH) diagnosed according to guidelines: mean pulmonary
 artery pressure >20 mmHg, pulmonary vascular resistance ≥3 wood units, pulmonary
 arterial wedge pressure ≤15 mmHg during baseline measures at the diagnostic
 right-heart catheterization

 Exclusion Criteria:

 -  resting partial pressure of oxygen <8 kilopascal at Zürich altitude on ambient air

 -  exposure to an altitude >1000 m for ≥3 nights during the last 2 weeks before the study

 -  inability to follow the procedures of the study

 -  patients who take nitrates

 -  other clinically significant concomitant end-stage disease (e.g., renal failure,
 hepatic dysfunction)