Thoracic Ultrasound on Upper Gastrointestinal Bleeding (ECOBLEDSTUDY)
Thoracic Ultrasound on Upper Gastrointestinal Bleeding (ECOBLEDSTUDY)
Upper Gastrointestinal bleeding (UGIB) is a medical emergency and the most common cause of
 hospitalization associated with digestive disease. Proper initial resuscitation is the first
 step in the management of UGIB patients. Today, modern pulmonary ultrasound is used in
 different clinical settings, such as intensive care, emergency medicine and/or traumatology.
 In the last years, the use of this has been standardized both in internal medicine and in
 pulmonary medicine. The primary objective is to describe the findings of pulmonary ultrasound
 and its relationship with severity in patients with UGIB. The investigators will include all
 patients with UGIB. A pulmonary and vena cava ultrasound will be performed on admission to
 the emergency room, 10 minutes prior to endoscopy and 24 hours after having performed the
 endoscopy.

 The use of thoracic point-of-care ultrasound (TPOCUS) has been standardized in both internal
 and pulmonary medicine. There is a concern about the role of TPOCUS useful as a severity
 prognostic tool in patients with UGIB.

 The team proposes that TPOCUS is a severity prognostic tool in UGIB patients.

 Main Outcome: To describe the findings of TPOCUS in patients with variceal and non-variceal
 UGIB.

 Secondary Objectives:

 1. Correlate the presence of B-type lines on TPOCUS with mean arterial pressure in UGIB
 patients.

 2. Correlate the inferior vena cava diameter with the Model for End-stage Liver Disease
 scale in UGIB patients.

 3. Correlate the inferior vena cava diameter with the 48 hours post-admission mortality of
 UGIB patients.

 Authors design a prospective, longitudinal, descriptive study to identify the findings of
 TPOCUS in patients with variceal and non-variceal UGIB. Patients will be included in the
 study since May 15th through October 30th 2019, admitted to the University Hospital, "Dr.
 José E. González", Universidad Autónoma de Nuevo León.
Inclusion criteria:

 1. Patients with a diagnosis of UGIB documented by endoscopy.

 2. Any gender.

 3. Over 18 years old.

 Exclusion criteria:

 1. Patients with UGIB previously treated in other hospitals.

 2. Patients under 18 years of age.

 3. Patients with suspected UGIB who did not undergo endoscopy.

 4. Pregnant.

 5. Patients with chronic obstructive pulmonary disease.

 6. Patients with interstitial lung disease.

 7. Patients with pleural effusion at the time of admission to the emergency room.

 8. Refusal to participate in the protocol.

 Method The investigators will study all patients who come to the emergency room of the
 hospital due to suspicion of UGIB (melena, hematemesis, vomiting in coffee grounds and
 hematochezia with hemodynamic instability). These patients will undergo a pulmonary and vena
 cava ultrasound.

 Patients with suspected UGIB who are candidates for upper endoscopy during their hospital
 stay will undergo a second pulmonary and vena cava ultrasound ten minutes prior to upper
 endoscopy.

 The investigators will include in the research study patients with UGIB documented by upper
 endoscopy. The investigators will perform a third pulmonary and vena cava ultrasound 24 hours
 after the endoscopic procedure.

 The investigators will exclude patients with suspected UGIB but who are not candidates for
 endoscopy.

 The technique used is a bilateral intercostal thoracic point-of-care ultrasound (TPOCUS) with
 the patient in supine decubitus with the head at 30 degrees. Each hemithorax will be divided
 into 4 areas: anterior and lateral, superior and inferior. The anterior area will be
 delineated between the clavicle and the diaphragm and between the parasternal line to the
 anterior axillary line. The lateral area will be delineated between the axilla and the
 diaphragm and between the anterior to the posterior axillary line. The superior area will be
 delineated from the 1st to the 3rd intercostal space and the lower area from the 4th to the
 6th intercostal space. A total of 8 areas of the chest will be visualized during normal
 breathing.

 The TPOCUS findings to report are:

 B-type lines: Those lines are hydro-aerial artifacts presenting as comet tail images, begin
 in the pleural line, are hyper-echoic, well defined, disseminated towards the end of the
 screen, delete A-type lines, and move with the pleural slip when this it is present. The
 lines separated from each other around 7 mm correspond to interstitial edema, while those
 that distance 3 mm indicate the presence of alveolar edema. The presence of more than 3
 B-type lines indicates the presence of an alveolar-interstitial syndrome.

 The inferior cava vein evaluation will be performed by measuring the diameter and percentage
 of collapse of this vein. It will be performed in the subxiphoid window with the
 identification of the four cardiac chambers, then a 90º turn of the transducer will made in
 the cephalad direction, which will show the right atrium, the union of the inferior vena cava
 and the liver above it. The diameter measurement will be beyond the point of confluence of
 the hepatic veins, usually found approximately 2 cm from the union of the inferior vena cava
 and the right atrium. Based on the diameter and collapse percentage measurement of the
 inferior vena cava on spontaneous breathing, a volume status will be defined as lack of
 volume if the diameter is <2 cm and the collapse percentage is >50%; however, a diameter >2
 cm and a collapse percentage <50% will be classified as hypervolemic state.
Inclusion Criteria:

 -  Age, more than 17 years old.

 -  Patients diagnosed with UGIB.

 -  Any etiology of the UGIB.

 Exclusion Criteria:

 -  Patients with UGIB previously treated in other hospitals.

 -  Patients with UGIB with Blatchford scale less than 2 points.

 -  Pregnant women.

 -  Refusal to participate in the protocol.