Proof Of Mechanism Study To Determine Efficacy Of PF-04455242 In Blocking Spiradoline (PF-00345768) Stimulated Prolactin Release
Proof Of Mechanism Study To Determine Efficacy Of PF-04455242 In Blocking Spiradoline (PF-00345768) Stimulated Prolactin Release
This study will be a Proof of Mechanism (POM) study to establish evidence of central
 pharmacodynamic activity for PF 04455242, and will be a parallel group, randomized, double
 blind, sponsor open study conducted in healthy male subjects. Once subjects achieve steady
 state of PF 04455242, they will undergo PF 00345768 (spiradoline) challenge. Data will be
 analyzed to determine whether PF-04455242 blocks spiradoline induced prolactin release.
Inclusion Criteria:

 -  Healthy male subjects between the ages of 21 and 55 years, inclusive (Healthy is
 defined as no clinically relevant abnormalities identified by a detailed medical
 history, full physical examination, including blood pressure and pulse rate
 measurement, 12 lead ECG and clinical laboratory tests.

 Exclusion Criteria:

 -  Evidence or history of clinically significant hematological, renal, endocrine,
 pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or
 allergic disease (including drug allergies, but excluding untreated, asymptomatic,
 seasonal allergies at time of dosing).