Depression and Facial Identity Recognition Abilities in Patients With Multiple Sclerosis
Depression and Facial Identity Recognition Abilities in Patients With Multiple Sclerosis
Cognitive and emotional disorders are often encountered in multiple sclerosis (MS) cases:
 depressive and bipolar disorders are twice as frequent as in general population.

 Cognitive disorders, (particularly attention and dysexecutive disorders), appear in early
 stages of the disease's evolution, in cases of lightly or moderately disabled patients, with
 a recent evolution, with a "minor" form of the disease, even in Clinically Isolated Syndromes
 (CIS). Emotional disturbances are essentially linked to mood disorders of depression-type.

 Last ten years, emotional processing in multiple sclerosis cases was investigated in various
 trials, especially regarding the recognition of facial and emotional expressions. These
 studies reported data, supporting an impairment of the perception of emotion, particularly
 those with negative valence.

 The objective of this study is to investigate the link between recognition of facial and
 emotional expressions and depression in multiple sclerosis cases.
Inclusion Criteria:

 -  Man or Woman between 18 and 65 years old

 -  Participant understanding and able to speak French

 -  Participant understanding the Participant Informed Sheet and who has signed the
 Informed Consent

 -  Participant with Health Insurance

 MS Patients :

 -  Patient with relapsing remitting multiple sclerosis form

 -  Expanded Disability Status Scale (EDSS) < 4

 -  Patient without motor disorders, cerebellar or significant upper limb somatosensory or
 visual disturbances

 Control Participants :

 -  Participant without global cognitive deterioration

 Exclusion Criteria:

 -  Participant taking part of other biomedical studies involving drug tests

 -  Participant with other neurological pathologies, head trauma with loss of
 consciousness, psychiatric pathologies, serious general affections, alcoholism,
 perception disorders, dysarthria, disorders preventing oral communication and reading,
 under prescription of psychotropic drugs

 -  Mental or visual incapacity to take part in the study

 -  Participant with antecedents of drug or alcohol abuse

 -  Allergy to the components of the gel used during the EEG

 -  Patients with MRI contraindications : Pacemaker or neurostimulator or Implantable
 Cardioverter Defibrillator (ICD), Cochlear Implants, ocular or cerebral ferromagnetic
 foreign body close to the nerve structures, metal prostheses,

 -  Uncooperative or agitated patients,

 -  Claustrophobic patients,

 -  Ventricular peritoneal shunts and neurosurgical valves,

 -  Braces

 -  MS patient without MRI in the last 4 months

 -  Adults under guardianship, under judicial protection, persons deprived of liberty,

 -  Pregnant or breast feeding women,

 -  MS patient with another MS form than Relapsing-Remitting,

 -  MS patient who encountered a relapse in the last 6 weeks,

 -  MS patient treated with corticoids in the last month.