Epigenetics Modifications in Morbid Obesity and Obstructive Sleep Apnea Patients: The EPIMOOSA Study
Epigenetics Modifications in Morbid Obesity and Obstructive Sleep Apnea Patients: The EPIMOOSA Study
This study evaluates epigenetics in morbid obese patients who are waiting for bariatric
 surgery. A home cardiopulmonary polygraphy is performed to evaluate for the presence of
 sleep-disordered breathing. The principal investigator make the decision of starting CPAP
 among patients with obstructive sleep apnea according to current clinical guidelines. One
 year follow up after bariatric surgery will be performed. A total of 5 visits will be
 scheduled: two of them before bariatric surgery and 3 after (3, 6 and 12 months).

 At every visit, all patients had: sleep questionaries, blood samples, EKG-Holter and
 spirometry are collected.
Inclusion Criteria:

 -  BMI consistently > 40 kg/m2 for 3-5 years, following more than 1 year of unsuccessful
 controlled medical treatment

 -  BMI 35-40 kg/m2 with comorbidities associated with morbid obesity (MO) susceptible to
 improvement with weight loss (high BP, Diabetes, dyslipidemia, OSA, etc.), following
 more than 1 year of unsuccessful controlled medical treatment.

 -  A signed informed consent form

 Exclusion Criteria:

 -  Obesity hypoventilation syndrome or treatment with positive pressure devices.

 -  Diagnosis of systemic inflammatory disease.

 -  Neoplastic diseases in the last 5 years.

 -  A cardiovascular event in the last 6 months.

 -  Pregnancy