Vitamin D Increases Serum Levels of the Soluble Receptor for Advanced Glycation End Products in Women With PCOS
Vitamin D Increases Serum Levels of the Soluble Receptor for Advanced Glycation End Products in Women With PCOS
The purpose of this study is to investigate the mechanism that explain the beneficial
 clinical effect of vitamin D treatment in women with PCOS.
Seventy-nine women with (n=22) or without (control; n=57) PCOS who were diagnosed with
 vitamin D deficiency were enrolled. Sixty-three women were treated with oral vit D3 for 8
 weeks (16 with PCOS and 47 controls) and 16 women were not treated (6 with PCOS and 10
 controls). Serum 25 hydroxy-vitamin D (25 OH-D), sRAGE, and AMH concentrations were measured
 at baseline and after vit D3 supplementation in the treated group, and 8 weeks apart in the
 non-treated group. Paired t-test, Wilcoxon signed-rank test, and Pearson correlation were
 used as appropriate.

 Main outcome measure: Changes in AMH concentrations following vit D3 replacement.
Inclusion Criteria:

 -  Vitamin D deficient premenopausal women

 Exclusion Criteria:

 -  Pregnant women

 -  Women during their postpartum period

 -  Breastfeeding women

 -  Women taking any kind of exogenous hormones

 -  Women receiving any form of oral vitamin D replacement