Comparison on Efficacy and Safety of Three Inpatient Insulin Therapy in Type2 DM
Comparison on Efficacy and Safety of Three Inpatient Insulin Therapy in Type2 DM
Purpose: To compare efficacy and safety of traditional sliding scale insulin (SSI) versus
 modified 70/30 insulin versus modified basal plus supplemental scale /bolus insulin regimens
 for glycemic control in hospitalized diabetic patients with diabetes.

 Methods: In a prospective trial, patients with diabetes will be randomized to receive either
 traditional hospital SSI , or twice daily 70/30 insulin plus supplemental lunchtime insulin
 for BG ≥ 150 mg/dL or once every night glargine plus three times prandial glulisine for BG ≥
 150 mg/dL . 70/30 insulin and glargine will be started respectively at 0.4 and 0.2 U/kg/day
 for BG ≤ 200 mg/dL or 0.5 and 0.3 U/kg/day for BG above 200 mg/dL.
Inclusion Criteria:

 -  known history of type 2 DM for longer than 3 months

 -  age between 18-64 year old,

 -  treatment with diet alone, any combination of oral antidiabetic agents and/or insulin
 before admission.

 Exclusion Criteria:

 -  subjects with hyperglycemia without any known history of DM

 -  presence of diabetic ketoacidosis (DKA)

 -  patients admitted to intensive care unit (ICU)

 -  subjects expected to undergo surgery during the hospitalization course

 -  patients with clinically relevant hepatic disease impaired renal function (serum
 creatinine ≥ 3.0 mg/dL) systemic infections pregnancy patients on medications known to
 interfere with the blood glucose level (either increasing or decreasing