A Population-Based Case-Control Study of Biliary Tract Cancers in Shanghai, China
A Population-Based Case-Control Study of Biliary Tract Cancers in Shanghai, China
The key aims of this study include estimation of possible risk associated with a history of
 gallstones, bacterial infection for the biliary tract, other medical history, diet, use of
 tobacco and alcohol, obesity, reproductive factors, and family history of cancer. Information
 will be used to examine risk patterns a) seperately by anatomic subsite; b) among patients
 with gallbladder cancer vs. controls undergoing cholecystectomy for gallstones; c) among the
 patients with bile duct cancer vs. Hospital controls without cancer who undergo surgery for
 removal of bile duct stones. We will also attempt to ascertain reasons for cancer who undergo
 surgery for removal of bile duct stones. We will also attempt to ascertain reasons for the
 rising incidence of biliary tract cancers in Shanghai. Serum collected from all subjects will
 be analyzed for estrogens and other hormones, vitamins C and E, cholesterol, and bacterial
 antibodies (including salmonella typhi, paratyphi, and escherischia coli). Bile fluid will be
 cultured for aerobic bacteria, and gallstones analyzed for color, cholesterol, and evidence
 of bacteria infection. A major challenge in biliary tract cancer research is to determine how
 cancer risk factors differ from those for gallstones or biliary duct stone disease, since
 many people have gallstones (or biliary duct stones) but few develop cancer....
The key aims of this study include estimation of possible risk associated with a history of
 gallstones, bacterial infection for the biliary tract, other medical history, diet, use of
 tobacco and alcohol, obesity, reproductive factors, and family history of cancer. Information
 will be used to examine risk patterns a) seperately by anatomic subsite; b) among patients
 with gallbladder cancer vs. controls undergoing cholecystectomy for gallstones; c) among the
 patients with bile duct cancer vs. Hospital controls without cancer who undergo surgery for
 removal of bile duct stones. We will also attempt to ascertain reasons for cancer who undergo
 surgery for removal of bile duct stones. We will also attempt to ascertain reasons for the
 rising incidence of biliary tract cancers in Shanghai. Serum collected from all subjects will
 be analyzed for estrogens and other hormones, vitamins C and E, cholesterol, and bacterial
 antibodies (including salmonella typhi, paratyphi, and escherischia coli). Bile fluid will be
 cultured for aerobic bacteria, and gallstones analyzed for color, cholesterol, and evidence
 of bacteria infection. A major challenge in biliary tract cancer research is to determine how
 cancer risk factors differ from those for gallstones or biliary duct stone disease, since
 many people have gallstones (or biliary duct stones) but few develop cancer.
-  INCLUSION CRITERIA:

 Cases of biliary tract cancer newly diagnosed between September 1, 1996 and August 31, 1999
 among residents of urban Shanghai.

 Must be under the age of 75 at the time of diagnosis.