A Placebo Controlled Study of MR901 (Talaporfin Sodium Sodium + a Drug-activating Device) for the Relief of Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia
A Placebo Controlled Study of MR901 (Talaporfin Sodium Sodium + a Drug-activating Device) for the Relief of Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia
This study investigates the safety and efficacy of a photosensitive drug (talaporfin sodium)
 activated by an intraurethrally placed drug-activating device. MR901 is a code used to
 identify the combination of talaporfin sodium and the drug-activating device. Two different
 light doses will be tested against placebo groups in this 4-arm study.
At least 192 patients with moderate-to-severe LUTS caused by BPH will be randomized in a
 2:2:1:1 ratio to receive a single treatment of talaporfin sodium activated by light at one of
 two light doses or placebo (saline) with light at either dose. Follow-up is planned for 52
 weeks from the day of treatment, with assessment at 12 weeks for change in International
 Prostate Symptom Score and continued follow-up during the remaining 40 weeks to assess
 duration of effect, need for any intervention, and longer-term safety.
Inclusion criteria:

 1. Males aged ≥40 years, weighing ≤200 Kg and able to provide written, informed consent.

 2. Documented symptoms of BPH-LUTS for 6 months or more.

 3. For patients regularly taking their prescribed BPH medication, dose should have been
 stable for at least 6 months for 5-alpha reductase inhibitors and 3 months for other
 BPH medications.

 4. For patients who have withdrawn from regularly taking their prescribed BPH medication,
 there should have been a 6 month washout period for 5-alpha reductase inhibitors and 3
 months for other BPH medications.

 5. Have a total International Prostate Symptom Score (IPSS; Qs 1-7) of ≥ 15 at both V1
 and V2 with a difference between those visits of ≤ 4 points.

 6. Prostate volume of 30 - 80 mL (inclusive).

 7. Maximum urinary flow rate (Qmax): 5 - 15 mL/sec (assessed on two voids each of ≥
 150mL).

 8. Prostate-specific antigen (PSA) ≤10 ng/mL.

 9. Post-void residual (PVR) volume ≤200 mL measured by a urinary catheter or bladder
 ultrasound according to local standard practice.

 10. Prostatic urethral length (PUL) of between 30 - 55mm (inclusive) as measured by TRUS.

 11. Willing and able to comply with photosensitivity precautions

 Exclusion criteria

 1. Any minimally invasive or surgical treatment within the last 12 months, and is not
 currently undergoing intraprostatic injections for BPH or any other prostatic
 condition. In any case, all enrolled subjects must have, at Baseline cystoscopy, an
 appearance/presentation of the prostate that is consistent with BPH and compatible
 with possible response to the study test treatment.

 2. Subjects weighing >200 Kg.

 3. Subjects with a history or current evidence of any of the following:

 1. A bladder disease or condition co-exists, such as idiopathic over-active bladder
 (OAB) and is evaluated by the Investigator as the predominant etiology for the
 subject's voiding symptomatology. A score of 4 points or greater on the 3 item
 OAB Awareness Tool (OABV3) or a high rate of urinary frequency (>13xday and/or
 4x/night) would require investigator specific evaluation in ascribing these
 symptoms to a bladder condition as opposed to lower urinary tract obstruction. i)
 If the former is the assessment, then the subject requires exclusion from the
 study. ii) If the latter is the assessment, then the subject may be deemed
 eligible for inclusion.

 The subject eligibility explanation must be captured in the patient source
 documents.

 2. Active urinary tract infection i.e. must have a screening urinalysis without
 signs of infection or negative urine culture. Must not have had a previous
 symptomatic urinary tract infection within 4 weeks of the study.

 3. Urethral stricture or any other anatomical feature that would complicate
 catheterisation.

 4. Interstitial cystitis.

 5. Predominant prostate middle lobe, as determined by the Investigator.

 6. Prostate or bladder cancer or bladder carcinoma-in-situ - in particular, evidence
 from digital rectal exam (DRE) of prostate abnormalities suggestive of cancer in
 the last 12 months.

 7. Any other absolute indication for urosurgical intervention (such as acute or
 frequent retention, currently untreated bladder or urethral stones, urethral
 strictures/bladder neck contracture (BNC)).

 8. Damage to the bladder neck which could interfere with study procedures.

 4. PSA level in excess of >10 ng/ml. If the PSA measurement is 2.5-10 ng/ml and/or has
 shown a clinically significant concerning increase in the last 6 months, local
 standard of care must be pursued to ensure the possibility of prostate cancer has been
 followed up and ruled out prior to study entry.

 5. Subjects who had had a prostate biopsy within 6 weeks prior to Screening.

 6. Any neurological condition affecting the bladder or a history of a neurogenic or
 chronically decompensated bladder i.e. neurogenic bladder, Parkinson's disease,
 history of chronic prostatitis within the last 5 years.

 7. Prior treatment for urinary incontinence.

 8. Requirements for daily incontinence pads or devices.

 9. Subjects in whom nocturia is due to etiologies other than their BPH-LUTS, such as
 neurogenic bladder, diabetic neuropathy, neurocongestive heart failure, hepatic
 failure, nephritic syndrome, sleep disorder.

 10. Previous or concurrent clinically relevant cardiovascular or cerebrovascular disorder
 within 24 weeks prior to the study i.e. unstable angina pectoris, myocardial
 infarction, transient ischemic attack, or cerebrovascular accident (stroke) within the
 past 6 months, or peripheral arterial disease with intermittent claudication or
 Leriche's syndrome.

 11. Presence of serious hepatic diseases, renal diseases, immunological diseases, or
 pulmonary diseases that are clinically relevant.

 12. Unwilling to use contraception for 3 months following administration of study
 medication or with an interest in future fertility.

 13. A prolonged QTcF interval at baseline and/or who are currently taking medication that
 prolongs QT interval ("prolonged QTcF interval" defined as > 450 ms).

 14. Known sensitivity to porphyrin-type drugs or known history of porphyria.

 15. Any contraindications to use of the study treatment.

 16. Active alcohol or drug abuse.

 17. Subject has clinical laboratory test results outside the reference ranges of the
 testing laboratory that are deemed to be clinically significant. Subjects with
 isolated test results that are outside the specified ranges and that are assessed as
 clinically insignificant will be allowed at the discretion of the Investigator, after
 discussion with the Sponsor's Medical Monitor/Study Physician, if appropriate. If a
 subject has 1 isolated test result outside the specific range that is deemed
 potentially clinically significant, rescreening may be allowed at the discretion of
 the Investigator, after discussion with the Medical Monitor/Study Physician

 18. Subjects with known disorders of coagulation, apart from those receiving anticoagulant
 / antithrombotic / antiplatelet therapy in whom the dose of such medication must have
 been stable for at least 1 month prior to randomisation. In those receiving Vitamin K
 antagonists (warfarin, acenocoumarol, phenindione, etc) the INR value at baseline
 should be <3.0.

 19. Inability or unwillingness to comply with the required photosensitivity precautions
 during the three weeks following study treatment.

 20. Subjects taking medications with a recognised propensity for causing photosensitivity
 (such as amiodarone, tetracyclines, sulphonamides) that cannot be discontinued for the
 initial study period, namely from 14 days prior to administration of study medication
 until 28 days afterwards.

 21. Subjects with medical or investigation results deemed unfit for study treatment, as
 determined by medical history, clinical laboratory tests, ECG results, and physical
 examination that, in the Investigator's opinion, preclude entry into the study.

 22. Subjects who have received an investigational medicinal product within 30 days or 5
 half-lives of the investigational product prior to study entry (defined as the start
 of the Screening Period).

 23. Subjects who are incapable of giving informed consent or complying with the protocol.