Mesenchymal Stem Cell Transplantation in Osteoarthritis of Hip Joint
Mesenchymal Stem Cell Transplantation in Osteoarthritis of Hip Joint
Osteoarthritis of the hip is a common type of osteoarthritis which can cause significant
 problems. First-line of management for patient with osteoarthritis consists of weight
 reduction, education, and analgesic medication. If necessary, invasive treatment like total
 hip replacement are performed for the patient. The objective of this study was to assess the
 safety of bone marrow mesenchymal stem cells (BM-MSCs) implantation in patients with hip
 osteoarthritis
This is a phase one clinical study designed to investigate the safety of intra-articular
 injection of cultured autologous BM-MSCs in patients with severe hip osteoarthritis candidate
 for total hip replacement. All subjects will undergo bone marrow aspiration. Autologous MSCs
 will be extracted and cultured for 4 weeks. Patients will receive intra-articular injection
 of cultured MSCs under the guide of fluoroscopy. Paraclinical studies (X-Ray and MRI) will be
 done before and 6 months after treatment. Pain relief and functional improvement of the joint
 will be assessed by VAS, WOMAC, and Harris Hip Score questionnaire before treatment, and 2
 and 6 months after treatment.
Inclusion Criteria:

 -  Osteoarthritis diagnosed by MRI

 -  End stage osteoarthritis candidate for total hip replacement

 Exclusion Criteria:

 -  Pregnancy or lactating

 -  Positive tests for HIV, HCV, HBV

 -  Active neurologic disorder

 -  End organ damage

 -  Uncontrolled endocrine disorder