Impact of Nerve-sparing Radical Hysterectomy on Patients' Urinary Dynamics
Impact of Nerve-sparing Radical Hysterectomy on Patients' Urinary Dynamics
Background: Radical hysterectomy is an important therapy for early cervical cancer.
 Disfunction of urinary dynamics is the most common postoperative adverse effects, which had
 negative impact on patients' quality of life. Nerve sparing radical hysterectomy (NSRH) could
 reserve inferior hypogastric plexus (IHP) innervating bladder, hence improving postoperative
 urinary dynamics. Furthermore impact of different energy instruments on urinary dynamic isn't
 clear.

 Objectives: This study is to compare urinary dynamics before and after NSRH, and to analyze
 the difference between BiClamp forcep (BiClamp® forcep, ERBE Elektromedizin, GmbH, Tuebingen,
 Germany) and water jet (ERBEJET®2) about the effects of dissecting IHP.

 Study population: Cervical cancer of FIGO IB stage, among which 120 cases are enrolled to
 randomly allocated to BiClamp group or water jet group.

 Intervention: Patients accept NSRH which all will be accomplished by Professor Ming Wu.

 Methods: All surgical patients are accessed via urinary dynamics before and four months after
 NSRH. On the 14th day after surgeries, urinary catheter will be removed and residual urine
 volume (RUV) will be measured. For patients of RUV > 100 ml, urinary catheter will be
 replaced.

 Primary study endpoint: the successful rate of removing urinary catheter on the 14th day
 after NSRH.

 Secondary study endpoint: urinary dynamics four months after NSRH.
Inclusion Criteria:

 -  FIGO stage IB

 -  ASA score 0-2

 Exclusion Criteria:

 -  Radiotherapy or chemotherapy before surgeries

 -  ASA score > 2

 -  With abnormal urinary dynamics before surgeries