Evaluation of the Interference of Antithrombotic Agents With Laboratory Monitoring of Heparin Therapy
Evaluation of the Interference of Antithrombotic Agents With Laboratory Monitoring of Heparin Therapy
Oral anticoagulants are increasingly prescribed and the are not discontinued for invasive
 cardiac procedures .

 Additional parenteral anticoagulation is necessary for these procedures (FA ablation and
 invasive coronary explorations).

 The unfractionated heparin doses are adapted on a monitoring test heparin, activated clotting
 time (ACT) with the aim of obtaining and maintaining an ACT > 300-400 sec. This goal is the
 same whether the patient is on oral anticoagulant treatment or not, and regardless of the
 initial level of anticoagulation.

 The effects of oral anticoagulants on routine coagulation tests (PT, APTT, TT) are well
 documented, but few data have been published on the effects of heparin monitoring tests,
 particularly on the ACT.

 The aim of this stuy is to redefine the target values of ACT and unfractionated heparin doses
 to administer to optimize the efficacy / safety of invasive procedures in cardiology.
Inclusion Criteria:

 -  patient treated with oral anticoagulant at curative dose and requiring a requiring a
 venous blood sample for his management

 Exclusion Criteria:

 -  opposition to the patient to participate to the study