PHARMO Institute Seroquel Safety Study
PHARMO Institute Seroquel Safety Study
The purpose of this observational study is to study specific outcomes of interest in users of
 quetiapine compared with all other atypical antipsychotics and specifically olanzapine and
 risperidone. The outcomes of interest are all-cause mortality, failed suicide attempts,
 extrapyramidal symptoms, diabetes mellitus, hypothyroidism, acute myocardial infarction and
 stroke. This retrospective cohort study is based on population-based record linkage system
 (PHARMO RLS) capturing about 2.5 millions residents in the Netherlands.
Inclusion Criteria:

 -  Episode of new use of atypical antipsychotics in naïve (not used antipsychotic drugs
 for a year) users of antipsychotics.

 Exclusion Criteria:

 -  less than a year of recorded history before the cohort entry date

 -  use of multiple antipsychotics concomitantly

 -  duration and dose of the antipsychotic drug cannot be determined