Albumindialysis in Acute Pancreatitis
Albumindialysis in Acute Pancreatitis
The incidence of acute pancreatitis has been doubled during last three decades in Finland.
 Alcohol is the main cause of acute pancreatitis in Finland accounting for 70 % of cases.
 Although the mortality of acute pancreatitis has been decreased it still appears and
 especially early multiple organ failure is the main cause of all deaths. Multiple organ
 failure in the early course of the disease is thought to be caused by the release of
 cytokines. Molecular adsorbent recirculating system (MARS) has shown to decrease mortality in
 acute alcohol hepatitis and paracetamol intoxication. Also it has been shown to improve
 kidney function due to hypoperfusion and tubulus necrosis and overrule decrease mortality in
 patients with multiple organ failure due to different reasons. A part of patients with acute
 alcoholic pancreatitis may have so-called fat liver already on admission. It has been shown
 that the highest mortality is especially associated those with early liver and kidney
 failure. MARS treatment has never earlier been used in the patients with acute alcoholic
 pancreatitis and early organ failure. In this study we randomize patients with acute
 alcoholic pancreatitis and early multiple organ failure (Sofa score>2) to two groups: 1)
 Standard pancreatitis treatment in intensive care unit and 2) Standard pancreatitis treatment
 in intensive care unit with 5 MARS sessions.
Inclusion Criteria:

 -  Severe acute alcoholic pancreatitis with early multiple organ failure (Sofa score >2)

 Exclusion Criteria:

 -  If patient or his/her family member refuses, pregnancy.