Efficacy of Metronidazole Prophylaxis Against Clostridium Difficile-Associated Diarrhea in High Risk Adult Patients
Efficacy of Metronidazole Prophylaxis Against Clostridium Difficile-Associated Diarrhea in High Risk Adult Patients
The purpose of this study is to test if metronidazole prophylaxis is effective in decreasing
 the incidence of hospital induced Clostridium Difficile diarrhea among patients at high risk
 for this infection.
Clostridium Difficile infection or C. Diff (CDI) is an infection that causes severe diarrhea.
 Risk factors for this infection include hospitalization, the use of antibiotics, along with
 medications that decrease the acid in the stomach. This infection leads to a disease which is
 difficult to treat and can cause serious complications including death in rare cases. This
 infection also increases medical costs by prolonging hospital stays.

 Metronidazole (known by the brand name Flagyl) is an antibiotic that has been available for
 decades and has been used to treat this disease. Flagyl is approved by the Food and Drug
 Administration for the treatment of C. diff infection. Recent research by the investigators
 group has shown that hospitalized patients who took Flagyl had a decreased chance of getting
 C. Diff infection. However, high quality studies are needed to better evaluate whether the
 investigators can prevent C. Diff infection in high risk patients with the use of Flagyl.

 The purpose of this study is to assess if metronidazole prophylaxis is effective in
 decreasing the incidence of hospital induced Clostridium Difficile diarrhea among inpatients
 at high risk for this infection.

 High risk patient population are as defined below: taking a broad spectrum antibiotics
 (piperacillin/tazobactam-Zosyn; Ciprofloxacin).
Inclusion Criteria:

 -  Inpatients >55

 -  Proton Pump inhibitor / Histamine-2 Blocker

 -  On broad spectrum antibiotics (Zosyn and/or Ciprofloxacin). These two antibiotics are
 selected based on current hospital formulary/use

 -  Anticipated hospital stay >48 hours

 -  Mental capacity (able to give informed written consent).

 Exclusion Criteria:

 -  Admission for CDI

 -  Existing diarrhea at admission

 -  Passed prophylactic window (>48 hours on broad spectrum antibiotics)

 -  Unable to take PO at the time of evaluation for study entry

 -  No more than 14 days of broad spectrum antibiotics anticipated

 -  Medications with serious interactions/contraindications to that would be taken
 together with metronidazole (ex. Warfarin, disulfiram, phenytoin, calcineurin
 inhibitors)

 -  Inflammatory Bowel Disease

 -  Admission for colonic bowel surgery or h/o total/Subtotal colectomy)

 -  Hospice

 -  Mortality expected <7days

 -  Previous CDI in the past 6 months

 -  Intensive care admission due to the difficulty of monitoring them

 -  Allergy to Metronidazole or other Antibiotics in protocol

 -  Patients with neuropathy

 -  History of heavy ethyl alcohol intake(greater than 3 drinks daily) or intake in past
 24 hours,Solid organ transplant.