Emotional Prosody Treatment in Parkinson's
Emotional Prosody Treatment in Parkinson's
This study investigates a treatment protocol which holds the potential to significantly
 improve communication and quality of life for individuals affected by Parkinson's disease
 (PD). Disorders of emotional communication are widely reported in PD and can negatively
 impact quality of life by increasing social isolation and decreasing independence.
 Individuals with emotional prosodic communication disorders are often perceived as depressed
 or unconcerned about others. This seeming negativity can cause difficulties in relationships,
 and increased feelings of stress and burden in caregivers which may result in earlier
 placement in an institutional care setting. This innovative treatment program could improve
 care for individuals with PD, as well as other individuals who may be affected by disorders
 of emotional prosodic communication (e.g., stroke or traumatic brain injury).
Individuals with Parkinson's disease (PD) present with a variety of motor symptoms including
 resting tremor, difficulty initiating movement/slowed movements, and rigidity. While these
 motor signs and symptoms are the hallmark features, individuals with PD also often
 demonstrate changes in communication ability, with an estimated prevalence of 89 percent of
 all individuals with PD being affected. These disorders of communication have been reported
 by individuals with PD and their caregivers to be one of the most difficult aspects of living
 with this disorder.

 The most commonly diagnosed communicative disorder in PD is hypokinetic dysarthria which can
 result in changes in prosody, respiratory control, voice quality, and articulation. Of these,
 the disorders in prosody have been judged to be the most prominent deficit. Prosody includes
 the pitch, loudness, and rate with which speech utterances are produced and is used to
 communicate emotional connotation (e.g. angry versus sad). Impairments in speech prosody
 reduce the ability to communicate emotional feelings or intentions as well as reducing the
 intelligibility of the spoken message. While pharmacological treatments have been shown to be
 effective in improving motor function, these medications have not been shown to greatly
 mitigate speech production disorders including prosody, suggesting that therapies other than
 dopaminergic agents are needed to address prosody deficits in PD. Despite a negative impact
 on quality of life and reduced independence of individuals affected by emotional prosodic
 disorders, no published studies are available testing therapies to improve production of
 emotional prosody in PD.

 The primary goal of this proposal is to compare a treatment protocol shown to be effective in
 treating emotional prosodic deficit in stroke and TBI (Leon et al., 2005; Rosenbek et al.,
 2006) to a standard clinical treatment for prosody deficit that does not target the emotional
 aspect of the disorder in individuals with PD. The experimental treatment targets increased
 pitch and loudness variability, and control of speech rate, the core characteristics of
 prosodic insufficiency in PD, but with an emphasis on the emotional component of the
 disorder. The primary aims of the study are to determine treatment effect size by measuring
 the difference of the experimental protocol versus standard clinical care on prosodic deficit
 in individuals with PD via changes in acoustic and perceptual measures, as well as provide
 psychometric validation of test-retest reliability of the outcome measures.
Inclusion Criteria:

 -  Experimental subjects must meet the Brain Bank criteria (Gibb & Lees, 1988) for
 idiopathic PD.

 -  All participants must:

 -  be between the ages of 45 and 85

 -  have at least a sixth grade education

 -  fluent in English

 -  The investigators will obtain information about participant's Parkinson's disease
 history from medical records including:

 -  age at onset

 -  current age

 -  gender

 -  handedness

 -  level of education

 -  side of the body initially affected

 -  information regarding subsequent clinical progression

 -  medications

 -  most recent Unified Parkinson Disease Rating Scale (UPDRS) scores

 -  Hoehn and Yahr (H&Y) (Hoehn & Yahr, 1967) scores

 -  The investigators will include subjects with H&Y Stages between 2 and 4

 -  Participants must be judged as having at least a mild level of affective prosodic
 deficit in pretreatment testing

 Exclusion Criteria:

 -  Individuals will be excluded with other forms of Parkinsonism such as:

 -  multiple systems atrophy

 -  Lewy body dementia

 -  progressive supranuclear palsy

 -  Other exclusionary criteria will be:

 -  co-existing dementia (as indicated by score on Montreal Cognitive Assessment of
 below 26)

 -  neurological disease other than idiopathic PD

 -  major depression

 -  any other psychiatric illness

 -  chronic medical and neurological diseases other than PD (e.g., cardiac failure,
 renal disease, hepatic failure, stroke, or severe sensory deficits such as
 deafness or blindness (corrected visual acuity less than 20/50).