Ulinastatin Improves Postoperative Oxygenation After Cardiopulmonary Bypass
Ulinastatin Improves Postoperative Oxygenation After Cardiopulmonary Bypass
Retrospective study determine whether ulinastatin enhances postoperative pulmonary
 oxygenation after cardiopulmonary bypass (CPB).
This retrospective study evaluate patients who underwent aortic valvular surgery under
 moderate hypothermic CPB. The patients were classified into two groups: patients in whom
 high-dose ulinastatin (10,000 U/kg and 5,000 U/kg/h) was administered during CPB (Group-U);
 and patients in whom ulinastatin was not administered (Group-C). We measured PaO2/FiO2 at the
 following time points: before CPB (Pre-CPB), 2 hours after weaning from CPB (Post-CPB) and
 within 6 hours after admission to the ICU. The lengths of ventilator care and ICU stay were
 also reviewed.
Inclusion Criteria:

 -  patients who underwent aortic repair or replacement under moderate hypothermic CPB

 Exclusion Criteria:

 -  Preoperative:

 < 19 years old, > 85 years old, emergency operation, reoperation, left ventricular ejection
 fraction < 50%, arrhythmia, ischaemic myocardial disease, uncontrollable hypertension or
 hypotension, pericardial disease, pre-existing hepatic dysfunction, pre-existing renal
 dysfunction or underlying lung disease.

 -  Intraoperative:

 intraoperative application of an intra-aortic balloon pump, administration of steroids or
 tranexamic acid, and transfusion of fresh frozen plasma or platelet concentrates during
 CPB.

 -  Postoperative:

 reoperation for surgical correction of intractable postoperative bleeding within 2 hours
 after the end of surgery and transfusion of any banked blood products.