The Gut Microbiota of Bipolar and Depression
The Gut Microbiota of Bipolar and Depression
Background: The gut microbiome is emerging as an important factor in regulating mental health
 yet it remains unclear what the target should be for psychiatric treatment. Investigators aim
 at elucidating the complement of the gut microbiome community for individuals with Major
 Depressive disorder (MDD) and Bipolar disorder (BD) relative to controls, and test for
 relationships with symptoms.

 Methods: Investigators prospect to recruit subjects including patients and controls amount to
 240. All subjects will be collected for blood and stool samples,assessed by clinical scales.
 Finally, analyzing the correlation among the metabolon in blood, microbiota in stool and
 clinical scales to obtain the possible interaction between diseases and gut microbiota.
Background: MDD (Major Depressive disorder) and BD (Bipolar disorder), whose specific
 pathogenesis is still unclear, are both a multi-factorial disease being caused by biological,
 psychological and social factors. Accumulating evidence suggests that gut microbiota play an
 important role in brain functions and in the pathogenesis of neuropsychiatric diseases, such
 as autism, anxiety, as well as depression. No study has thus far compared the human gut
 microbiota among BD, MDD and the healthy control (HC). The aim of this study is to compare
 the composition of fecal microbiota among BD, MDD and HC. Furthermore, investigators aim at
 identifying direct correlations between human fecal microbiota (as a proxy for gut
 microbiota) and symptoms.

 Methods:

 1. Investigators aim at recruiting human subjects in total 240, which including mania
 episode of bipolar disorder (40), depressive episode of bipolar disorder (40), mixed
 episode of bipolar disorder (40), first episode of major depressive disorder (40),
 recurrent episode of major depressive disorder (40), and healthy control (40). All
 patients, diagnosed according to the research criteria of the 10th revision of the
 International Statistical Classification of Diseases and Related Health Problems
 (ICD-10）, come from The First Affiliated Hospital of Xi'an Jiaotong University and
 controls are healthy volunteers.

 2. Collecting blood and stool samples, evaluating clinical scales including
 Montgomery-Asberg Depression Scale (MADRS), Young Mania Rating Scale (YMRS), Hamilton
 Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), Measurement And Treatment
 Research To Improve Cognition In Schizophrenia (MATRICS) Consensus Cognitive Battery
 (MCCB), Clinical Global Impression (CGI) are all finished in first day after threshold.

 3. Measure the metabolon in blood such as S-CFA, and gut microbiota.

 4. Using Statistical Program for Social Sciences (SPSS) to compare general and clinical
 data among groups and analyze the correlation between the microbiota and symptoms.
Inclusion Criteria:

 -  Conforms to the diagnosis of bipolar disorder or major depressive disorder.

 -  Take antibiotics continuously less than 3 days in recent 3 months.

 -  17.5≦BMI≦30

 -  Age≦65

 Exclusion Criteria:

 -  who is diagnosed with physical diseases and other mental diseases.

 -  pregnant or lactational women

 -  who is diagnosed with mental retardation.