Ventricular Tachyarrhythmia Detection by Implantable Loop Recording in Patients With Heart Failure and Preserved Ejection Fraction
Ventricular Tachyarrhythmia Detection by Implantable Loop Recording in Patients With Heart Failure and Preserved Ejection Fraction
Heart failure with preserved ejection fraction (HFPEF) is a large medical problem, for which
 no drug or device has a recommendation in current heart failure guidelines. Sudden cardiac
 death is suggested as the most common cause of death in HFPEF patients, although data is
 sparse. Use of an Implantable Loop Recorder (ILR) may be useful in patients with HFPEF to
 evaluate the incidence of sustained ventricular tachyarrhythmias. If ventricular
 tachyarrhythmias are seem frequently, treatment with an Implantable Cardioverter
 Defibrillator (ICD) may be an option in the future.
Inclusion Criteria:

 Clinical criteria:

 1. Age >18 years

 2. Written informed consent

 3. HF with moderate to severe symptoms NYHA II or III

 4. Hospitalization or emergency room visit for HF or symptom relief with diuretics within
 12 months

 5. Sinus rhythm or AF

 Echocardiographic criteria:

 1. LVEF >40%

 2. Left atrial size (volume ≥34 mL/m2 or LA parasternal diameter ≥45), or left
 ventricular hypertrophy (septal thickness or posterior wall thickness ≥11 mm) or LV
 diastolic dysfunction (E/e' ≥13 or mean e' septal and lateral wall <9 cm/s).

 Biomarker criteria:

 1. BNP >100ng/L or NT-pro-BNP>400ng/L if sinus rhythm

 2. BNP >300ng/L or NT-pro-BNP>1200ng/L if atrial fibrillation

 Exclusion Criteria:

 1. Patients unwilling or unable to sign informed consent

 2. Patients with a pacemaker or ICD

 3. Indication for ICD therapy according to the ESC guidelines

 4. Life expectancy of less than one year

 5. Significant coronary artery disease or myocardial infarction < 3 months

 6. Complex congenital heart disease

 7. Pregnancy