Genetic Characteristics of HER2 Positive Breast Cancer With Neoadjuvant TCHP Chemotherapy
Genetic Characteristics of HER2 Positive Breast Cancer With Neoadjuvant TCHP Chemotherapy
Locally advanced breast cancer (LABC) is defined as breast cancer (BC) larger than 5
 centimeters or with lymph node metastasis. Usually, LABC is treated with neoadjuvant
 chemotherapy (NAC) followed by curative surgery to reduce tumor size and eliminate
 micrometastasis. Response to NAC helps predict BC prognosis. Pathologic complete response
 (pCR), defined as no residual tumor cells after NAC, represents prolonged survival without BC
 recurrence and residual cancer burden score, based on residual tumor volume, and can more
 accurately predict BC outcomes. Especially, Human epidermal growth factor receptoor type
 2(HER2)-positive breast cancer, having aggressive biologic characteristics, was mostly
 treated by NAC because of recent advance of highly effective targeted agents (pertuzumab and
 trastuzumab). However, still 30-40% of HER2-positive breast cancer did not response to NAC
 and underwent disease recurrence. Recently, genetic studies to find biomarker of BC prognosis
 have been widely performed. Circulating tumor DNA (ctDNA), which is circulating free DNA in
 the blood that originates from cancers, can be detected by recently-developed technologies.
 CtDNA could facilitate early disease detection, diagnosis and detection of disease
 recurrence. CtDNA also provides a genomic profile of BC and predicts drug response. In BC,
 ctDNA correlates with tumor burden and provides early detection of treatment response and
 tumor genetic alterations.

 In this study, the investigator aimed to identify the correlations in genomic profile between
 tumors and ctDNA during NAC(docetaxel /carboplatin /trastuzumab and pertuzumab) in HER2
 positive breast cancer.
Inclusion Criteria:

 -  HER2+ Breast cancer

 -  Stage IIA - IIIC

 -  Plan to receive neoadjuvant chemotherapy with docetaxel, carboplatin, herceptin,
 perjeta

 -  Sign to informed consent

 Exclusion Criteria:

 -  Double primary cancer