Does Meal Timing Affect Energy Expenditure
Does Meal Timing Affect Energy Expenditure
The purpose of this study is to find out if meal timing affects calories burned and blood
 sugar levels.
10 overweight adult men and women will eat according to two different eating schedules:
 grazing and time-restricting feeding ("early eating"). While on each eating schedule,
 metabolism (calories burned) will be measured during a 24-hour stay in a respiratory chamber.
 Glucose levels-as well as key diurnal rhythms such in heart rate-will also be measured
 continuously. This study requires two 1-week periods of participation.
Inclusion Criteria:

 -  Are 20-45 years of age

 -  Have a weight between 150 and 220 lbs

 -  Have a body mass index between 25 and 35 kg/m2 inclusive (a number calculated from
 your height and weight)

 -  If you are a female, have a regular menstrual cycle that is between 25 and 35 days
 long

 -  If you are female, had your period within the last 35 days

 -  Regularly go to sleep between 9:30 pm and 12:00 am

 -  Regularly eat dinner 9 or more hours after eating breakfast

 -  Are willing to have about 2/3 cup of your blood stored for future research related to
 this study

 Exclusion Criteria:

 -  Have diabetes or are on anti-diabetes medication

 -  Suffer from significant cardiovascular, renal (kidney), cardiac (heart), liver, lung
 or nervous system disease

 -  Have stomach or intestinal problems

 -  Regularly use medications such as steroids, beta blockers, adrenergic-stimulating
 agents, and laxatives

 -  Take any medications or supplements known to affect sleep, circadian rhythms, or
 metabolism (with the exception that certain forms of birth control are allowed)

 -  Have abnormal lab work that is clinically significant in the opinion of the study
 physician

 -  Are pregnant or lactating

 -  Take the Depo Provera shot, or use an Interuterine Device (IUD) or hormone patch for
 birth control

 -  If you are on hormonal birth control, have been on a stable dose for less than 3
 months

 -  Have smoked or used nicotine/tobacco products within the last 3 months

 -  Regularly do competitive sport training

 -  Perform overnight shift work an average of one or more times per week

 -  Have an irregular sleep schedule

 -  Have an irregular eating schedule

 -  Regularly drink 3 or more drinks of alcohol per day

 -  Are not able or are unwilling to eat only the food and drink served to you by
 Pennington Biomedical, while in the study

 -  Are not able or are unwilling to refrain from strenuous exercise while participating
 in the study

 -  Are not able to spend 2 separate full days (for about 25 hours each) at Pennington
 Biomedical

 -  Are not able to maintain a consistent sleep schedule while participating in the study

 -  Are not able to maintain a consistent eating schedule while participating in the study

 -  Are not able to stop drinking coffee and other caffeine-containing drinks on the day
 of and day prior to testing