Cessation of Long Term NAs vs. Keeping on NAs Among CHB Patients (CNAVK)
Cessation of Long Term NAs vs. Keeping on NAs Among CHB Patients (CNAVK)
To Identify the collected cases who can stop NAs safely with satisfactory clinical outcome
 including sustain viral remission and HBsAg clearance among chronic hepatitis B(CHB)
 patients.
Nucleos(t)ides analogues(NAs) is a safe and effective treatment among chronic hepatitis
 B(CHB) patients with excellent tolerance. Entecavir or tenofovir mono therapy has been shown
 to achieve inhibition of HBV replication in almost all adherent patients. However, HBsAg loss
 rate is low even after long-term NAs treatment. Recent studies indicated that cessation of
 NAs treatment could increase HBsAg clearance rate. Identifying the collected cases who can
 stop NAs safely with satisfactory clinical outcome including sustain viral remission and
 HBsAg clearance is very important.
Inclusion Criteria:

 1. HBsAg positive, HBeAg negative, antibody to HBeAg-positive;

 2. Stable administration of anti-HBV neucleos(t)ides analogue mono therapy for at least
 more than one and a half year;

 3. Demonstration of undetectable HBV DNA on three occasions, each at least 6 months
 apart, which is consistent with the APASL stopping rule;

 4. Patients read, understand the consent form, and signed the study consent.

 Exclusion Criteria:

 1. Patient with other liver diseases;

 2. Patient with concurrent hepatitis viruses or HIV infection;

 3. Patients are reluctant to stop their anti-HBV treatment.