National Survey of Essential Tremor Plus in China
National Survey of Essential Tremor Plus in China
National Survey of Essential Tremor Plus in China（NSETP-China）is a multicenter
 cross-sectional study designed to investigate the clinical features of ET-plus in mainland
 China.
Essential tremor (ET) is one of the most common adult-onset movement disorders, affecting
 0.9% of the population across all ages worldwide. ET is a chronic, progressive neurologic
 disease whose the most recognizable clinical feature is a 4~12 Hz kinetic tremor of the upper
 limbs, usually occurring during a variety of voluntary movements. The etiology and
 pathogenesis of ET remain elusive.

 Essential tremor-plus (ET-plus) is a new term coined in 2018 MDS consensus statement on
 tremor. ET-plus is defined as tremor with the characteristics of essential tremor, with
 additional neurological signs of uncertain clinical significance, such as impaired tandem
 gait, questionable dystonic posturing, memory impairment, or other mild neurological signs of
 unknown clinical significance that do not suffice to make an additional syndrome
 classification or diagnosis.

 ET-plus is a controversial new concept. We will use scales or questionnaires to investigate
 the common soft neurological signs of ET-plus in mainland China. The details are as follows:
 (1) The tremor's impact on activities of daily living and clinical measurement of ET severity
 are evaluated by The Essential Tremor Rating Assessment Scale (TETRAS). (2) Cognitive
 condition is assessed by Mini Mental State Examination (MMSE) and Montreal Cognitive
 Assessment (MOCA). (3) The non-motor symptoms are evaluated by Non-motor Symptom Scale
 (NMSS). (4) Clinical assessment of balance and gait in ET-plus: we will use Tandem walk, Berg
 balance scale (BBS) and 10 meter walk timing test. (5) The Unified Dystonia Rating Scale
 (UDRS) for evaluation of dystonia in ET-plus. (6) The scale for the Assessment and Rating of
 Ataxia (SARA) is used to evaluate ataxia in ET-plus.
Inclusion Criteria:

 Patients diagnosed with ET and/or ET-plus by the Consensus Statement on the Classification
 of Tremors, from the Task Force on Tremor of the International Parkinson and Movement
 Disorder Society.

 Exclusion Criteria:

 Lack of capacity to consent to participate in the project