Sleep Spindles and Memory in Rolandic Epilepsy
Sleep Spindles and Memory in Rolandic Epilepsy
The investigators are recruiting children with Rolandic epilepsy and children without
 epilepsy (aged 4 years old and above) for a non-invasive brain imaging study using Magnetic
 Resonance Imaging (MRI), Magnetoencephalography/Electroencephalography (MEG/EEG), and
 experimental tasks. The investigators hope to determine the brain circuits and brain rhythms
 affected in these children and ultimately identify new treatment options for childhood
 epilepsy patients.
This is a prospective study of epilepsy biomarkers in a total of 100 subjects of ages 4-18.
 Participants will spend about 5 hours at the Massachusetts General Hospital (MGH) Athinoula
 A. Martinos Center for Biomedical Imaging. They will undergo training on a memory task
 concurrent with EEG/MEG recordings. During the EEG, subjects will wear headphones that will
 deliver a quiet pink noise stimulus intermittently during a nap. The auditory stimulus will
 be calibrated in volume to not cause arousals. After napping, subjects will undergo cognitive
 testing and memory task testing.
Inclusion Criteria:

 1. Ages 4-18 years

 2. Diagnosed with childhood epilepsy with centrotemporal spikes (CECTS) or Rolandic
 epilepsy by child neurologist

 3. Has EEG with sleep activated centrotemporal spikes

 4. Has had at least 1 focal motor or generalized seizure

 Exclusion Criteria:

 1. Has abnormal brain MRI

 2. Has other unrelated neurological disease

 3. Unable to have an MRI/MEG

 1. Claustrophobic

 2. History of frequent vomiting

 3. Permanent metal in body, braces

 4. Over MRI weight limit: 350lbs