Hyperproteic Diet Plus Lactobacillus Reuteri and Nitazoxanide in Minimal Hepatic Encephalopathy
Hyperproteic Diet Plus Lactobacillus Reuteri and Nitazoxanide in Minimal Hepatic Encephalopathy
Hepatic encephalopathy is a serious complication of cirrhosis which relays under the burden
 of diseases with therapeutical difficulties for its given morbidity and mortality and the
 high recurrence it poses. Its treatment remains a challenge for most of the cases. Even more,
 minimal hepatic encephalopathy is an entity that has an additional morbidity for it being a
 subclinical entity. As so, the investigators propose an auxiliary treatment for the
 management of such patients with minimal hepatic encephalopathy, using a specific diet
 consisting on hyperproteic and fibre-rich foods along with two independent interventions,
 whether a probiotic, lactobacillus reuteri, or a drug, nitozoxanide, so to diminish the rate
 of progression to any clinical stage of hepatic encephalopathy and to revert minimal hepatic
 encephalopathy itself to none hepatic encephalopathy.
Inclusion Criteria:

 -  Hepatic Cirrhosis

 -  Minimal hepatic Encephalopathy

 Exclusion Criteria:

 -  Personal history of surgery in the last 4 weeks

 -  Use of neuropsychiatric drugs

 -  Neuropsychiatric disorders (Schizophrenia, bipolar disorder, major depression,
 dementia and Attention-deficit hyperactivity disorder)

 -  Thyroid disorders without replacement therapy

 -  Hepatic or renal transplant

 -  Alcoholism with active ingest of alcohol in the last 6 months

 -  Pregnancy

 -  Labour turn-overs

 -  Spontaneous bacterial Peritonitis

 -  Personal history of hepatocellular carcinoma

 -  Placement of transjugular intrahepatic portosystemic shunt

 -  Use of a probiotic in the last 6 months