Placental Transfusion in Term Infants: A Pilot Study
Placental Transfusion in Term Infants: A Pilot Study
The proposed study is a pilot prospective controlled trial to measure the blood volume left
 in the placenta after varying cord clamping times when the infant is placed skin-to-skin on
 the maternal abdomen. Delaying cord clamping has been shown to decrease anemia in infants.
 However, the best way to get the most blood to the baby is not known. The practice of cord
 clamping at birth is not the same among doctors and midwives and we do not know the effect of
 putting he baby on the mother's abdomen.
The proposed study is a pilot prospective controlled trial to measure the placental residual
 blood volume after varying cord clamping protocols when the infants are placed skin-to-skin
 on the maternal abdomen. The study assessed compliance of the providers with the different
 protocols. Placental transfusion (PT) has been shown to increase infant body iron stores at 6
 months of age without increasing adverse outcomes. However, the optimal protocol to achieve
 adequate placental transfusion is not known. The practice of cord clamping at birth is not
 uniform among obstetrical providers because adequate evidence to support early or late cord
 clamping has been lacking.

 Women were eligible to enroll in the study if they had no pregnancy complications, did not
 smoke, planned to breastfeed, and planned to deliver vaginally between 37 and 416/7 weeks.
 Women were enrolled prenatally on the labor and delivery unit. At birth, women were assigned
 to one of four cord clamping/milking groups. A cohort of infants with immediate cord clamping
 serves as reference group. Infants had blood samples drawn with the routine newborn screening
 blood samples done at 36 to 48 hours. Information on infant health and feeding was completed
 through an in-hospital visit to the mother and by home visit at two weeks of age. The primary
 outcome measures were placental residual blood volume and compliance with the various
 assigned cord clamping protocols. It was expected that infants with delayed cord clamping or
 cord milking would have less placental residual blood volume and that most providers would
 comply with the various random assignments.
Inclusion Criteria: Women with normal pregnancy and presented at the labor room at 38-416/7
 weeks for vaginal delivery; Intention to breast feed the babies; Consent for a follow up at
 2 weeks of age

 Exclusion Criteria: Abnormal pregnancy: Gestational or pre-existing diabetes, smoking and
 substance abuse, pre-eclampsia, fetal abnormality