Effect of Hypercholesterolemia With or Without Hypertension on Coronary Artery Stenosis in Patients With Angina: a Retrospective Study
Effect of Hypercholesterolemia With or Without Hypertension on Coronary Artery Stenosis in Patients With Angina: a Retrospective Study
A multicenter, retrospective clinical study was carried out in the medical records management
 system of 6 hospitals in Tianjin. Patients who were suffered with Coronary heart disease
 angina pectoris and underwent coronary angiography are collected. The investigators collect
 and analyze the demographics, laboratory information, clinical outcome data, and coronary
 angiographic data of patients. To explore the correlation between hypercholesterolemia and
 the degree of coronary artery stenosis of Coronary heart disease angina pectoris, and to
 further research the influence of hypertension on total cholesterol level and coronary artery
 stenosis, and provide guidance for clinical prevention and treatment.
Based on the total cholesterol level, the investigators divided patients into 3 groups:
 patients with TC < 5.18 mmol/l belong to normal TC (NTC) group, 5.18 ≤ TC < 6.19 mmol/l is
 borderline-high TC (BHTC) group, those with TC ≥6.19 mmol/l belong to high TC (HTC) group,
 and the correlation between the TC and the degree of coronary artery stenosis is evaluated.
 With or without hypertension will be further stratified to assess the effect of with or
 without hypertension on the correlation between TC levels and the degree of coronary artery
 stenosis. The 6 subgroups are: NTC/-HTN group, NTC/+HTN group, BHTC/-HTN group, BHTC/+HTN
 group, HTC/-HTN group, HTC/+HTN group.

 The investigators refer to the recent diagnostic guidelines for coronary heart disease angina
 pectoris at home and abroad. The diagnosis can be given if it meets any one or more of the
 following:

 1. There was a clear history of old myocardial infarction.

 2. Previous coronary angiography or coronary CTA examination showed that at least one major
 branch of coronary artery has a lumen diameter stenosis ≥50%.

 3. Those with ST-segment depression or T-wave inversion on ECG after coronary
 revascularization.

 The investigators will redefined hypertension as systolic blood pressure ≥130 mmHg or
 diastolic blood pressure ≥80 mmHg according to the recently published 2017 ACC/AHA
 guidelines.
Inclusion Criteria:

 1. Patients aged from 35 to 75 years old, male or female.

 2. Those who were hospitalized between September 1, 2014 and September 1, 2019.

 3. Patients with Coronary heart disease angina pectoris and have undergone coronary
 angiography in the inpatient department of cardiovascular internal medicine.

 4. The diagnosis of hypercholesterolemia, Coronary heart disease angina pectoris and
 hypertension is accorded with the diagnostic criteria.

 Exclusion Criteria:

 1. Those with other cardiac diseases, gastroesophageal reflux disease or hiatal hernia,
 neurosis, spinal or vertebral artery cervical spondylosis, hyperthyroidism,
 climacteric syndrome, etc.

 2. Those with myocarditis, cardiomyopathy, acute myocardial infarction, third degree of
 heart failure, severe heart valve disease, major diseases such as malignant tumor and
 serious metabolic diseases, liver failure or renal failure.

 3. Those with psychotic disorders, or cognitive dysfunction.

 4. Those of childbearing age and have fertility requirements, or pregnant women or
 lactating women.

 5. Those allergic to iodine contrast medium.

 6. Those who are not suitable for the study, as judged by the researcher.