Pulmonary Vein Diameter and Collapsibility Measured by TEE to Predict Elevated Left Atrial Pressure in Cardiac Surgery
Pulmonary Vein Diameter and Collapsibility Measured by TEE to Predict Elevated Left Atrial Pressure in Cardiac Surgery
Left atrial pressure (LAP) is a crucial hemodynamic parameter during cardiac surgery.
 Elevated LAP leads to pulmonary edema and other cardiopulmonary complications. The pulmonary
 capillary wedge pressure (PCWP) measured by a pulmonary arterial catheter (PAC) is the
 gold-standard method to estimate LAP. However, the placement of a PAC is an invasive
 procedure associated with adverse events. Transesophagial echocardiophy (TEE) is a
 non-invasive method to estimate LAP during cardiac surgery. Pulsed Doppler mitral flow,
 pulmonary vein flow, tricuspid regurgitation peak flow and left atrial volume are validated
 parameters to estimate LAP. Nevertheless, these parameters are not always valid in cardiac
 surgery, mainly because of mitral valve pathology or prothesis.

 As the diameter and collapsibility of inferior vena cava is the recommended method for
 non-invasive right atrial pressure assessment in patients under mechanical ventilation, the
 investigators made the hypothesis that diameter and collapsibility of the pulmonary veins
 could be an additional method to estimate LAP during cardiac surgery. This has never been
 investigated in cardiology or cardiac surgery.

 In this prospective study, pulmonary vein diameter and collapsibility will be correlated to
 invasive PCWP to assess LAP perioperatively in 30 patients undergoing cardiac surgery
The evaluation of left ventricle filling pressures (LVFP) perioperatively in cardiac surgery
 could be challenging. This is particularly relevant after separation from cardiopulmonary
 bypass because the hemodynamic state is dynamic, with changes in heart rate, loading
 conditions, and deterioration in diastolic function being common. Elevated LVFP leads to
 pulmonary edema, arrhythmia, pulmonary hypertension and RV failure.

 To estimate the LVFP, the gold standard method is the pulmonary capillary wedge pressure
 (PCWP) measured by a pulmonary arterial catheter (PAC). However, placement of a PAC is an
 invasive procedure associated with adverse events.

 Recommandations released by the American Society of Echocardiography for the evaluation of
 left ventricular diastolic function pointed out some difficulties concerning the evaluation
 of elevated LAP perioperativly in cardiac surgery. The commonly used parameters, such as the
 mitral pulsed Doppler flow, could be faulted by mitral valve regurgitation, atrial
 fibrillation, or fast changes in loading conditions. In cardiac surgery, additional
 diagnostic methods are needed to diagnose elevated LVFP.

 In the right heart, measurements of the inferior vena cava diameter and collapsibility index
 are recommended for the evaluation of the right atrial pressure. Since it has been previously
 described that alterations of the pulmonary vein Doppler flow are correlated with elevated
 LAP, pulmonary vein diameter dilatation or lack of collapsibility have never been
 investigated as a marker of elevated LAP, neither in cardiology nor in cardiac surgery.

 In this study, the investigators made the hypothesis that pulmonary vein diameter increase
 when LAP increase (in the absence of confounding factors, such as pulmonary vein stenosis or
 mitral regurgitation directed toward the pulmonary vein). In the same way,the investigators
 hypothized that cyclic variations of pulmonary vein diameter under mechanical ventilation
 decrease when the LAP increase. The ventilation parameters will be standardized.

 The investigators will conduct a prospective study in the Department of cardiothoracic
 anesthesiology and critical care medicine, at the Montpellier University Hospital. Patients
 scheduled for an elective cardiac surgery and requiring pulmonary arterial catheter
 monitoring will be enrolled. The TEE standardized protocol will be performed three times,
 before and after cardiopulmonary bypass, and one-hour postoperatively in ICU. The mean PCWP,
 the standard method for measuring the LAP, will be recorded simultaneously by the pulmonary
 arterial catheter. For patients with atrial fibrillation, measurements will be averaged from
 10 consecutive cycles.

 The main objective is to correlate left upper pulmonary vein diameter and collapsibility with
 invasive PCWP. We have chosen to analyze the LUPV as the main marker because the LUPV is the
 easiest to measure among the four pulmonary veins in our clinical practice. Secondary
 objectives are to explore the correlation between the recommanded LAP echocardiographic
 parameters and the PCWP ; and to compare the area under curve (AUC) of all echocardiographic
 parameters to define which parameter has the best predictive value to diagnose elevated LAP.
 An elevated LAP is defined by a PCWP greater than 18 mmHg.

 The study protocol has been approved by the Institutional Rview Board under the number
 2019_IRB-MTP_05-21. The IRB waived the need for the investigator to obtain signed consent
 forms. We have planned to include 30 patients in this study
Inclusion Criteria:

 -  Patients aged of 18 years or more,

 -  Scheduled for an elective cardiac surgery at the Montpellier University Hospital,

 -  Requiring a pulmonary arterial catheter monitoring due to the complexity of cardiac
 surgery or severe cardiopulmonary comorbidities.

 Exclusion Criteria:

 -  Failure of the pulmonary artery catheterization,

 -  Failure of PCWP measurement,

 -  Failure of TEE measure of the left upper pulmonary vein diameter and collapsibility,

 -  Refusal to participate expressed secondarily.

 Non-inclusion criteria :

 -  Cardiac transplantation,

 -  Left ventricule assist device,

 -  Pulmonary vein stenosis,

 -  Contraindications to TEE or PAC,

 -  Refusal to participate,

 -  Patient under juridical protection