Acupuncture in the Treatment of Depression
Acupuncture in the Treatment of Depression
The current large randomized placebo-controlled trial is testing the ability of acupuncture
 to treat major depression. The study is unique in that treatment effects will be from the
 perspective of both Western psychiatry and Chinese medicine.
Depression is an unfortunately common condition for which people often seek alternative
 (non-Western) treatments, perhaps because conventional treatments do not consistently provide
 lasting relief. A pilot study (Allen, Schnyer and Hitt, 1998) suggests that acupuncture, a
 popular but under-researched alternative treatment derived from Chinese medicine, holds
 sufficient promise as a treatment for depression to warrant a larger-scale clinical trial.
 The investigators propose to conduct a larger-scale test of the efficacy of acupuncture in
 this trial. Because relapse and recurrence of Major Depression are quite common, the
 investigators also will assess the clinical status of participants for 18 months after
 treatment concludes. In the first phase of this double-blind randomized clinical trial, 150
 men and women meeting criteria for Major Depression will be randomly assigned to a treatment
 approach or to a waitlist control. All participants will ultimately receive acupuncture
 designed to address their own particular constellation of depressive symptoms. At the end of
 this first phase, blind assessments will be used to compare treatment effects from the
 perspectives of both Western psychiatry and Chinese medicine. After this treatment phase,
 participants will be assessed several times over the next 18 months. The study is designed to
 evaluate the efficacy and clinical significance of acupuncture as a treatment for Major
 Depression, and to examine the convergence of Western-based and Chinese-medicine-based
 outcome measures. Finally, the study will determine whether changes in energetic pattern
 mediate changes in Western defined depression severity, and explore whether patient and
 history variables predict responses to acupuncture treatments.
Inclusion Criteria:

 -  Must meet criteria for Major Depression.

 -  Must be free of other mental or physical disorders that could cause depression, and
 also free from conditions that would typically exclude participants from trials
 involving pharmacologic antidepressants.

 -  Cannot be receiving other treatments or require immediate clinical attention.