Molecular Studies and Clinical Correlations in Human Prostatic Disease
Molecular Studies and Clinical Correlations in Human Prostatic Disease
The Genitourinary Oncology/Urology Services at Memorial Sloan-Kettering Cancer Center (MSKCC)
 participates in research for the control, treatment, and cure of cancer. The purpose of this
 study is to collect normal and cancerous tissues, in addition to blood, and other body fluid
 samples from men with prostate cancer or prostatic disease. These samples may be stored for
 future use or used immediately by researchers who study prostate cancer and try to find
 better ways to diagnose, prevent, and treat it. We will look for genetic changes and protein
 markers on these cells. We hope to learn more about what makes some people get prostate
 cancer, why some cancers are more aggressive than others, and why some cancers respond to or
 resist different treatments. We may also try to grow the tumor cells in the lab. We may find
 a new treatment for prostate cancer based on this research.
The therapeutics program for advanced prostate cancer is based on the hypothesis that the
 factors contributing to and associated with progression change as the disease evolves. To
 categorize these changes we now consider the disease as a series of states. 1 The states
 represent points where an intervention might be considered to prevent cancer from developing,
 to eliminate established disease, or to delay progression. The states also represent
 clinically significant milestones that can be used to assess treatment effects.
Inclusion Criteria:

 Men with prostate conditions representing the following disease states:

 -  No Cancer Diagnosis

 -  Clinically Localized Disease

 -  Rising PSA

 -  Clinical Metastases: Noncastrate

 -  Clinical Metastases: Castrate (Testosterone ≤ 50 ng/ml)

 -  Signed informed consent

 Exclusion Criteria:

 -Patients without any prostate related problems.