The Predictive Value of Complement C3 in Patients With Advanced Gastric Cancer
The Predictive Value of Complement C3 in Patients With Advanced Gastric Cancer
This study is designed to investigate whether complement C3 depletion is associated with poor
 short-term outcomes in postoperative patients with gastric cancer.
The complement system plays an important role in the development of digestive malignancies.
 The complement C3 is the point of convergence for the three complement activation pathways.
 However, the concrete effect of C3 in the development of gastric cancer is still obscured.
 This study is designed to explore whether complement C3 can be regarded as a predictive
 factor of postoperative outcomes for postoperative patients with gastric cancer.

 This study is designed as a prospective cohort study and included consecutively treated
 patients. The perioperative plasma value of complement components, such as C3, C4, and CH50,
 are detected to explore the incidence rate of complement depletion. All enrolled patients are
 divided into two groups mainly according to the levels of preoperative C3 levels (C3
 depletion and Non-C3 depletion groups). The primary endpoints are the 1-year overall survival
 and disease-free survival, while the secondary endpoints are postoperative complications,
 length of hospital stay, and hospital charges.

 This study would be helpful to confirm the role of complement depletion in anticipated
 outcomes of postoperative patients with gastric cancer.
Inclusion Criteria:

 -  Pathological diagnosis of gastric adenocarcinoma

 -  Radical operation and adjuvant chemotherapy endurable

 -  Informed consent approved

 Exclusion Criteria:

 -  Age <18 or >75 years old

 -  Pregnancy or lactating woman

 -  Any primary diagnosis other than gastric cancer

 -  Confirmed complement deficiency due to immunity dysfunction or other disease

 -  Required blood transfusion, plasmapheresis, or emergent operation