Long Term Follow-up of Bone Mineral Density in Hormone Treated Turner Syndrome
Long Term Follow-up of Bone Mineral Density in Hormone Treated Turner Syndrome
Turner Syndrome (TS) is associated with osteopenia and osteoporosis. Reduced bone mineral
 density (BMD) and increased risk of fractures are present in many younger and middle-aged
 women with TS. The objective is therefore to describe longitudinal changes in BMD in TS.

 The study is an observational follow-up study. Examinations at baseline, after 5 and 10
 years.

 Bone mineral density is measured by dual energy x-ray absorptiometry (DEXA) and bone turnover
 by bone markers.

 Main Outcome Measures: Bone mineral density (BMD; grams/ square centimetre) were measured at
 lumbar spine, hip and the non-dominant forearm.
Inclusion Criteria:

 -  Turner syndrome verified by karyotyping

 Exclusion Criteria:

 -  untreated hypothyroidism or hyperthyroidism

 -  present or past malignant diseases

 -  clinical liver disease

 -  treatment with drugs known to interfere with bone metabolism (e.g. glucocorticoids)