Effects of Somatostatin on Post-endoscopic Portal Hemodynamic in Cirrhotic Patients With Esophageal Gastric Varices
Effects of Somatostatin on Post-endoscopic Portal Hemodynamic in Cirrhotic Patients With Esophageal Gastric Varices
The main complications of cirrhosis are ascites, esophageal varices and hepatic
 encephalopathy. About 30% to 70% patients with cirrhosis occur esophageal varices, and the
 most common complication is ascites. Somatostatin is used to treat esophageal for a long
 time, otherwise it could aslo prevent ascites. In the study, the investigators explore the
 effects of somatostatin on post-endoscopic portal hemodynamic in cirrhotic patients with
 esophageal gastric varices.
126 patients will be enrolled in the study, 63 subjects will be randomized into the group A
 and the other will be into the group B.

 Group A: endoscopic therapy and somatostatin treatment. Group B: endoscopic therapy.
Inclusion Criteria:

 -  Cirrhosis with esophageal gastric varices needed endoscopic therapy

 -  Age 18-75 years

 -  Informed written consent

 Exclusion Criteria:

 -  Use of vasoactive drugs 24 hours before endoscopic treatment

 -  Use of B-blocker within 1 week

 -  Previous surgical or endoscopic treatment for esophageal gastric varices

 -  Hepatic encephalopathy,comatose status and any other disease which could not accept
 endoscopic therapy

 -  Gastro-renal vein shunt

 -  Severe hepatic hydrothorax

 -  Hepatocellular carcinoma with portal vein thrombosis

 -  Severe coagulation disorders

 -  Severe active bacteria infection

 -  Severe cardiovascular disease, including a history of acute myocardial
 infarction,heart block, heart failure

 -  Severe renal function insufficiency （Calculated Creatinine Clearance Rate (Ccr)
 <30ml/min）

 -  Severe co-morbidity that would affect short-term prognosis

 -  Pregnancy or lactation

 -  Allergy to any ingredient of trial medication

 -  Medical or psychological condition that would not permit the patient to complete the
 study or sign the informed consent