Oral Vancomycin to Prevent Recurrent C Difficile Infection With Antibiotics
Oral Vancomycin to Prevent Recurrent C Difficile Infection With Antibiotics
This study will assess the efficacy of oral vancomycin prophylaxis in preventing recurrent
 Clostridium difficile infection in hospitalized patients requiring oral or intravenous
 antibiotics for a suspected or confirmed bacterial infection.
This study will assess the efficacy of oral vancomycin prophylaxis in preventing recurrent
 Clostridium difficile infection in hospitalized patients requiring oral or intravenous
 antibiotics for a suspected or confirmed bacterial infection.
Inclusion Criteria:

 1. Age ≥18 years

 2. Previous CDI diagnosis

 3. Current admission with a suspected or a confirmed bacterial infection requiring
 antibiotics

 Exclusion Criteria:

 1. Active chronic diarrheal illness (eg, Crohn's disease, ulcerative colitis, short bowel
 syndrome)

 2. Previous adverse reactions to oral vancomycin

 3. Requiring metronidazole during hospitalization

 4. Known pregnancy

 5. Expected survival <72 hours

 6. Patients receiving antibiotics only for surgical prophylaxis

 7. Patients who received prophylactic oral vancomycin for the current antibiotic course
 prior to enrollment in the study