Remediation Program Via a "Serious Game" for the Cognitive Functions of Multiple Sclerosis Patients
Remediation Program Via a "Serious Game" for the Cognitive Functions of Multiple Sclerosis Patients
The main goal of this study is to assess the effectiveness of a cognitive remediation program
 based on a "serious game" on the information processing speed evolution and the process of
 learning via episodic memory in multiple sclerosis patients.
Cognitive impairment affects 40 to 70% multiple sclerosis patients. This condition is
 characterized by slower information processing, associated with deficits in episodic memory,
 attention and executive functions. These disorders appear early, regardless of functional
 impairment, in "benign" forms and in clinically isolated syndromes of multiple sclerosis.
 These disruptions can have a significant impact in the socio-professional and personal life
 of patients and also in the quality of life (job loss risks, daily activities limitations).

 Even if these disorders are now well documented, remediation strategies remain less studied.
 Some studies show that the "training" methods, often used, do not seem suitable for clinical
 monitoring, with benefits that do not persist over time. Despite their impact on daily life,
 no specific care for planning abilities, mental inhibition and flexibility, or even social
 cognition, have been well studied until today. The same is true concerning metacognitive
 abilities. Finally, remedial techniques are time consuming and difficult to adapt to patients
 still in professional activity.
Inclusion Criteria:

 -  Relapsing-remitting or progressive multiple sclerosis people defined according to Mc
 Donald's criteria revised in 2005

 -  Age between ≥ 18 and ≤ 65 years old

 -  Cognitive complaint, with at least one deficient score at the initial
 neuropsychological examination (<5th percentile of the reference group), one of the
 scores of which concerns at least one BICAMS test

 -  Have not had a definite relapse for at least 6 weeks

 -  Be at least 4 weeks away from a corticosteroid bolus

 -  Lack of neuroleptic treatment

 -  Patient with an Internet connection

 -  Signed informed consent

 Exclusion Criteria:

 -  Severe cognitive deficit defined by obtaining a deficit score in more than six
 cognitive processes at the initial neuropsychological assessment.

 -  Neuropsychological care

 -  Inability to receive oral and written information

 -  Inability to use the software (due in particular to motor and / or sensory
 difficulties),

 -  Neurological or psychiatric comorbidity, other than MS and anxiodepressive syndrome

 -  Patient with severe anxiodepressive syndrome (BDI> 27)

 -  Participation in an interventional study on cognitive functions

 -  Patient under legal protection, guardianship or curatorship

 -  Pregnant or breastfeeding women