The Clinical Effect of Vitamin K Administration in Type 2 Diabetic Patients
The Clinical Effect of Vitamin K Administration in Type 2 Diabetic Patients
The aim of this study is to examine the possible clinical effects associated with vitamin K
 supplementation on the glycemic control, insulin sensitivity and lipid profile of type II
 diabetic patients.
Inclusion Criteria:

 -  Adult patients 21-65 years old diagnosed with Type II diabetes.

 -  Fasting blood glucose concentration ≥ 126 mg/dL .

 -  Normal liver Function tests defined as ALT levels up to 33 U/L for males and up to 25
 U/L for females, Albumin levels ≥ 3.5 g/dL, Bilirubin up to 1.1 mg/dL .

 -  Normal clotting function defined as defined by INR.

 -  Normal kidney function defined as serum creatinine values up to 1.3 mg/dL.

 Exclusion Criteria:

 -  Type I diabetic patients.

 -  Use of supplements with potential effect on vitamin K level namely supplements
 containing vitamin K, co-enzyme Q10 or vitamin E > 400 IU .

 -  Patients requiring anti-coagulant therapy including patients with prosthetic valves,
 mitral tissues, DVT, PE, atrial fibrillation and valvular heart disease.

 -  Patient with history of coagulation, MI, stroke and embolization.

 -  Pregnant or breast feeding women.

 -  Being on hormonal therapy or receiving contraceptive pills.

 -  Patients treated with glucocorticoids, thiazide diuretics, and atypical
 antipsychotics.

 -  Patients on cholestyramine, antibiotics and coumarins.

 -  Patients on lipid lowering agents.

 -  Known intestinal malabsorption syndrome, cholestasis or steatorrhea.

 -  Smokers.