Transcranial Magnetic Stimulation for the Treatment of Poorly Controlled Partial Epilepsy
Transcranial Magnetic Stimulation for the Treatment of Poorly Controlled Partial Epilepsy
Transcranial Magnetic Stimulation (TMS) is a non-invasive technique that can be used to
 stimulate brain activity and gather information about brain function. It is very useful when
 studying the areas of the brain related to motor activity (motor cortex, corticospinal tract,
 and corpus callosum).

 Epilepsy is a condition associated with seizures as a result of an over excitable cerebral
 cortex. Despite the introduction of several new antiepileptic medications, less than half of
 the patients diagnosed with partial epilepsy are well controlled. However, studies have shown
 that non-invasive stimulation of the brain can decrease the excitability of the cerebral
 cortex.

 Researchers are interested in the potential therapeutic effects of TMS on patients with
 epilepsy that have responded poorly to standard medication. This study will use TMS to
 decrease the excitability of the areas of the brain responsible for seizures.
The purpose of this protocol is to study the effects of transcranial magnetic stimulation
 (TMS) at 1 Hz on the excitability of the seizure focus in patients with poorly controlled
 epilepsy refractory to pharmacological treatments. 1 Hz TMS is a rate proven to induce long
 term depression in animal models and reported to decrease the excitability of both human and
 animal cerebral cortex.
Age 5 to 60 at entry to protocol.

 History of partial or Complex Partial Epilepsy for two or more years.

 Patients should be on a stable anti-convulsant regimen defined as unchanged medicines and
 dose modifications lower than 20% in the last month. Blood levels of anti-convulsants will
 be measured at the beginning of the study, prior to stimulation and after the study to
 assure that the type and dose of medication will remain constant.

 Seizures not completely responsive to medical treatment (1 or more seizures per week for at
 least 6 months) and patients have failed at least two anti-convulsant regimens in the past.

 The patients have a localized seizure focus.

 Epilepsy refractory to medical treatments.

 No pregnant women (will be tested with urine pregnancy test).

 No severe coronary disease.

 No metal anywhere in the cranium except the mouth.

 No intracardiac lines.

 No increased intracranial pressure as expressed by the presence of papilledema.

 No cardiac pacemakers.

 Must not be taking neuroleptic or antidepressant medications.

 No progressive neurologic disease.