The Effect of Exercise on Acute Nicotine Withdrawal
The Effect of Exercise on Acute Nicotine Withdrawal
The primary aim of this project is to test the effect of exercise on acute nicotine
 withdrawal. Acute nicotine withdrawal is characterized by a complex array of symptoms
 associated with increased risk of relapse among individuals attempting smoking cessation. The
 available remedies do not target all aspects of withdrawal. For example, pharmacologic
 treatments reduce withdrawal-based craving, but have no effect on cue-related craving,
 altered sleep, and mood disturbances during withdrawal. Therefore, non-pharmacologic
 behavioral techniques with the potential to attenuate persistent withdrawal symptoms are
 needed. We hypothesized that exercise can be a valid non-pharmacologic strategy to improve
 these domains.
The goal of the proposed work is to test: 1) the effects of exercise on mood, objective
 measures of sleep, and cue reactivity; 2) the effects of exercise at a given intensity and
 duration, after a short (few hours) and more prolonged (24 to 72 hours) abstinence from
 smoking; and 3) the effects of exercising in the morning versus exercising in the evening on
 the proposed outcome domains. We plan to implement a within-subject design that will allow us
 to collect measures for each subject aged 18 to 45 in four different conditions: 1) ad
 libitum smoking; 2) evening exercise after 2 to 72 hours of abstinence; 3) morning exercise
 after 2 to 72 hours of abstinence; and 4) no exercise after 2 to 72 hours of abstinence.
 Exercise will be conducted at a fixed and monitored dose and duration. By collecting morning
 and evening measures of withdrawal symptoms and cue reactivity, we will also test whether the
 effects of exercise in reducing withdrawal symptoms and cue reactivity will show a prolonged
 effect beyond the minutes/hours immediately after the exercise bout. We also hypothesize that
 the timing of exercise may have differential effects on different aspect of withdrawal. The
 proposed work will allow us to examine the extent to which exercise, a promising
 nonpharmacologic behavioral treatment method, can attenuate key symptoms of withdrawal
 recognized to impede abstinence efforts. A better understanding of these effects will allow
 us to implement exercise at the time of day that may be more troublesome for the individual
 attempting to quit. The development of new behavioral methods for attenuating withdrawal
 symptoms will be directly transferable to smoking cessation treatments aimed at reducing
 withdrawal symptoms and aiding efforts to avoid relapse after quitting smoking.
Inclusion Criteria:

 -  Age 18-45

 -  Not regularly exercising, defined as exercising fewer than three times per week and
 for no more than 20 minutes each time

 -  Free of medical illnesses (need to be cleared by a physician as able to exercise at
 60% maximum heart rate (MHR))

 -  Currently meeting DSM-IV criteria for nicotine dependence (No Current or Past history
 of any other psychiatric disorder)

 -  Regularly smoking at least 08 cigarettes per day for at least 12 consecutive months,
 not attempted to quit smoking in the previous month, and not currently taking
 medication for smoking cessation

 -  Currently displaying carbon monoxide breath readings >10 and urine cotinine levels >3

 -  Habitual bedtime between 9:30 p.m. and 1:30 a.m.

 -  Body Mass Index (BMI) less than 40.

 Exclusion Criteria:

 -  Unable to exercise

 -  Currently diagnosed or treated for any psychiatric disorder; treatment with
 psychotropic medication will be considered on a case by case basis

 -  History or active treatment or any treatment in past year for any mood or psychotic
 disorder

 -  Current or past diagnosis of a sleep disorder

 -  Currently taking sleep medications or other medications known to alter sleep
 architecture

 -  Currently doing shift work or working at night

 -  History of travel across time zones in the past month

 -  For women of child bearing potential: pregnant or actively trying to become pregnant

 -  Parent of a child under two years of age

 -  Diagnosis of Sleep Apnea