Risk Prediction in Type II Diabetics With Ischemic Heart Disease
Risk Prediction in Type II Diabetics With Ischemic Heart Disease
The purpose of this study is to test whether cardiac autonomic dysfunction predicts is a
 prognostic marker in type-2 diabetics with ischemic heart disease
In patients with type 2-diabetes and ischemic heart disease autonomic function might be
 seriously affected.

 In the present study, markers of cardiac autonomic dysfunction, repolarization and
 respiration abnormalities will be assessed from Holter recordings and 30-minute recordings of
 high-resolution three dimensional ECG, non-invasive arterial blood pressure and respiratory
 activity.

 The correlation between markers of cardiac autonomic dysfunction and markers of severity of
 type-2 diabetes will be assessed. Autonomic dysfunction is assumed present when both heart
 rate turbulence and deceleration capacity are abnormal ("severe autonomic failure").
 Assessment of severity of diabetes includes levels of HbA1c and urine albumine, duration and
 treatment of diabetes, and diabetes related complications (nephropathy, neuropathy,
 retinopathy).
Inclusion Criteria:

 -  type-2 diabetes

 -  coronary artery disease

 Exclusion Criteria:

 -  age >80 years

 -  acute coronary syndrome

 -  life expectancy <1 year

 -  unable to give informed consent