Assessment of Airway Responsiveness and Treatment Efficacy in Asthmatics
Assessment of Airway Responsiveness and Treatment Efficacy in Asthmatics
Bronchial asthma is a common chronic respiratory disease. Patients usually manifest variable
 symptoms (such as short of breath, chest tightness, cough, etc.) and variable airflow
 limitation and often associated with airway hyper-responsiveness and airway inflammation.
 About 1-18% of the global population suffered from the disease, causing huge economic burden
 for patients and countries. Airway reactivity measurement is an important way of diagnosis of
 asthma. Methacholine (Mch) bronchial provocation test(BPT) is the "gold standard" for the
 determination of airway reactivity, and other measuring methods(like adenosine
 monophosphate(AMP)-BPT, leukotriene D4(LTD4)-BPT, Astograph-BPT, etc.) were also brought into
 hot research fields. The investigators' purposes were to compare different kinds of
 methodologies(Mch,AMP,LTD4-BPT, Astograph-BPT) assessing airway responsiveness and to
 investigate treatment efficacy of budesonide /formoterol in asthmatics.
This study composed of two parts, that were the diagnosing part and the treatment part.
Inclusion Criteria:

 -  Clinically diagnosed Asthmatic patients aged from14 to 65 years；

 -  Had a had a normal chest radiographic result；

 -  Had a baseline spirometry with the forced expiratory volume in one second (FEV1) of
 not less than 60% predicted；

 -  Without acute upper respiratory tract infection for the past 2 weeks

 Exclusion Criteria:

 -  Smokers；

 -  Had a poor cooperation to the test or limited understandings;

 -  Had a past confirmed history of respiratory disease other than bronchial asthma (COPD,
 bronchiectasis, pulmonary thromboembolism, etc.) or other severe systemic
 disease（myocardial infarction, malignant tumor, etc.）;

 -  Pregnancy or breast-feeding women;

 -  Taken related drugs before measurements（Leukotriene receptor antagonists (LTRA) for 5
 days，oral glucocorticosteroid or anti-histamine for 3 days，oral xanthenes or
 long-acting bronchodilators for 2 days，inhaled corticosteroid or long-acting
 bronchodilator for a day , short-acting bronchodilator for 4 hours ）