The Effects of Nanocurcumin on Serum Oxidative Stress,Inflammation,Adiponectin and NF-kB in Blood Mononuclear Cells in Metabolic Syndrome Patients (Nuclear Factor-κB)
The Effects of Nanocurcumin on Serum Oxidative Stress,Inflammation,Adiponectin and NF-kB in Blood Mononuclear Cells in Metabolic Syndrome Patients (Nuclear Factor-κB)
Metabolic syndrome is a public health challenge that includes a range of conditions including
 abdominal obesity, dyslipidemia, hyperglycemia, and hypertension. The syndrome is associated
 with an increase in the risk of Cardiovascular disease and death. Curcumin is a very active
 compound obtained from turmeric root. Curcumin has antioxidant and anti-inflammatory effects,
 and is also involved in the regulation of several signaling pathways. Since curcumin powder
 has low bioavailability, fast metabolism and low absorption, nanomicielle curcumin will be
 used in this study. Therefore, this study is planned to determine the effects of
 supplementation of nanomicielle curcumin on oxidative stress, systemic inflammation,
 adiponectin in serum and NF-kB in peripheral blood mononuclear cells in patients with
 metabolic syndrome.
Inclusion Criteria:

 -  25<body mass index >40

 -  waist circumference >102 cm in men or >88 cm in women

 -  Fasting blood glucose >100 mg/dL

 -  Triglycerides (TG) > 150 mg/dL

 -  High density lipoprotein cholesterol (HDL-C) <50 in women or <40 in men

 -  Systolic blood pressure (SBP) >130 mmHg and diastolic blood pressure (DBP) >85mmHg

 Exclusion Criteria:

 -  insulin administration for diabetes control

 -  hypo- or hyperthyroidism,

 -  renal failure or other chronic diseases

 -  pregnancy and breastfeeding

 -  taking weight loss supplements and obeying unusual weight loss plans