Hemodynamic Effects of Terlipressin and High Dose Octreotide
Hemodynamic Effects of Terlipressin and High Dose Octreotide
The purpose of the study is to find patients's response to terlipressin and octreotide during
 hepatic venous pressure gradient measurement by observing portal and systemic hemodynamics.
Esophageal variceal bleeding is one of the main causes of death in cirrhosis patients.
 Prevention of bleeding events, including primary and secondary prophylaxis, is very important
 for reducing the mortality of variceal bleeding. Terlipressin and octreotide can effectively
 control bleeding with few side effects, which has been recommended by Baveno V in treatment
 of acute variceal bleeding. Terlipressin and high dose octreotide will be administered to the
 patients with cirrhosis related esophageal varices when they undergo hepatic venous pressure
 gradient measurement. Changes from portal and systemic hemodynamics will be observed to
 evaluate the safety and effects of terlipressin and high dose octreotide as well as to
 determine wether patients respond to them. The results can be served as clinical evidence for
 preventing re-bleeding through long-acting terlipressin and octreotide in the future.
Inclusion Criteria:

 -  Gastric and Esophageal Varices have been confirmed through endoscopy

 -  Liver Biopsy, CT or MRI indicates cirrhosis

 -  Patients who experienced variceal bleeding

 Exclusion Criteria:

 -  The patients who are beyond the range from 18 to 80 years old

 -  The patients with unstable vital signs

 -  The patients with spontaneous peritonitis or other severe infections

 -  The patients with hepatorenal syndrome or renal inadequacy

 -  The patients with uncontrolled hepatic encephalopathy

 -  Pregnant and lactating women

 -  The patients who had contraindications for terlipressin or octreotide

 -  The patients who refuse to take part in this study