Effects of Exercise on Functional Dyspepsia Based on Rome IV
Effects of Exercise on Functional Dyspepsia Based on Rome IV
Functional dyspepsia is one of the most common gastrointestinal disorders (FGIDs) encountered
 in clinical practice. Functional dyspepsia is a clinical syndrome characterized by chronic
 and recurrent gastroduodenal symptoms in the absence of any organic or metabolic disease that
 is likely to explain the symptoms. Functional dyspepsia has a high incidence in the
 population. A recent research showed that FD is present in 11% of the Italian general
 population. It dramatically reduces a patient's quality of life, with an economic impact due
 to frequent clinical consultations, medication, and time off work. Although some experts
 recommend exercise as a first-line treatment for functional dyspepsia, there is little data
 on the relationship between exercise and functional dyspepsia, which needs to be confirmed by
 further research. Investigators designed this randomized controlled study to assess the
 effect of exercise on patients with functional dyspepsia based on Rome IV criteria.
Functional dyspepsia is one of the most common gastrointestinal disorders (FGIDs) encountered
 in clinical practice. Functional dyspepsia is a clinical syndrome characterized by chronic
 and recurrent gastroduodenal symptoms in the absence of any organic or metabolic disease that
 is likely to explain the symptoms. Functional dyspepsia has a high incidence in the
 population. A recent research showed that FD is present in 11% of the Italian general
 population. It dramatically reduces a patient's quality of life, with an economic impact due
 to frequent clinical consultations, medication, and time off work.

 Regular physical activity and exercise may be a way of life to reduce low levels of
 inflammation throughout the body, thereby reducing the risk of developing chronic diseases.
 Multiple studies have shown that after regular exercise, markers of inflammation and
 oxidative stress are reduced, while markers of inflammation and antioxidants are increased,
 reflecting the anti-inflammatory and antioxidant properties of exercise.

 Rome IV was introduced in 2016. Rome IV introduced more precisely define the minimal
 thresholds for frequency and severity of each individual symptom, primarily for scientific
 purposes, but data still need to be collected to define thresholds based on the frequency
 and/or severity of symptoms that impair quality of life.

 Although some experts recommend exercise as a first-line treatment for functional dyspepsia,
 there is little data on the relationship between exercise and functional dyspepsia, which
 needs to be confirmed by further research. Investigators designed this randomized controlled
 study to assess the effect of exercise on patients with functional dyspepsia based on Rome IV
 criteria.
Inclusion Criteria:

 1. Age ≥18 years old

 2. Functional dyspepsia meeting Rome IV criteria

 3. Gastroscope, blood routine, liver function and Hp examination were performed within
 the last year, and the results were normal

 4. No prokinetic drug, proton pump inhibitor or mucosal protective agent was used in the
 last two weeks

 5. Sign informed consent and be willing to participate in this study

 Exclusion Criteria:

 1. There are organic diseases that may explain the symptoms, such as peptic ulcer,
 gastrointestinal neoplasms, history of hepatobiliary and pancreatic diseases, history
 of tumor diseases, and history of metabolic diseases

 2. Pregnancy, prepregnancy, or lactation

 3. History of abdominal surgery

 4. Mental illness

 5. Severe impairment of heart, liver, or kidney function or respiratory function

 6. Recent use of antidepressant, hormone, NSAIDs

 7. The main symptoms are gastroesophageal reflux disease or irritable bowel syndrome

 8. Failure to increase exercise levels