An Efficacy Study Comparing ZD6474 to Placebo in Medullary Thyroid Cancer
An Efficacy Study Comparing ZD6474 to Placebo in Medullary Thyroid Cancer
The purpose of this study is to learn how hereditary or sporadic medullary thyroid cancer
 patients, treated with ZD6474, react to the drug, what happens to ZD6474 in the human body,
 about the side effects of ZD6474, and if ZD6474 can decrease or prevent the growth of tumors.
Inclusion Criteria:

 -  Confirmed diagnosis of unresectable, locally advanced or metastatic hereditary or
 sporadic Medullary Thyroid Cancer.

 -  Presence of measurable tumor

 -  Able to swallow medication

 Exclusion Criteria:

 -  Major surgery within 4 weeks before randomization

 -  Last dose of prior chemotherapy received less than 4 weeks prior to randomization

 -  Radiation therapy within the last 4 weeks prior to randomization(with exception of
 palliative radiotherapy)

 -  Brain metastases or spinal cord compression, unless treated at least 4 weeks before
 first dose and stable without steroid treatment for 10 days

 -  Significant cardiac events

 -  Previous ZD6474 treatment