VITdAL@ICU - Correction of Vitamin D Deficiency in Critically Ill Patients
VITdAL@ICU - Correction of Vitamin D Deficiency in Critically Ill Patients
Study hypothesis:

 High-dose vitamin D leads to a shorter hospital stay in critically ill patients

 Vitamin D deficient patients will be randomized to receive either 540,000 IU cholecalciferol
 or placebo.
Inclusion criteria

 -  Age ≥18 years

 -  expected ICU stay ≥48 hours

 -  vitamin D deficiency: 25(OH)D ≤ 20 ng/ml

 -  feasibility of study drug application via nasogastric tube in cases where oral food
 intake is not possible

 Exclusion criteria

 -  moribund patient expected to die within 24 hours

 -  hypercalcaemia (total calcium >2.65 OR ion. calcium >1.35 mmol/l)

 -  severely impaired gastrointestinal motility (ileus, residual gastric volume > 400 ml)

 -  known history of recent kidney stones (≤ 1 year)

 -  known granulomatous diseases (tuberculosis, sarcoidosis)

 -  pregnancy

 Primary endpoint

 -  hospital stay (hours; starting from ICU admission) Secondary endpoints

 -  percentage of patients with 25(OH)D ≥ 30 ng/ml at day 7

 -  serum calcium; phosphorus; 25(OH)D; 1,25(OH)D; PTH; osteocalcin; bALP; TRAP; urinary
 calcium
Inclusion Criteria:

 -  Age ≥18 years

 -  expected ICU stay ≥48 hours

 -  vitamin D deficiency: 25(OH)D ≤ 20 ng/ml

 -  feasibility of study drug application via nasogastric tube in cases where oral food
 intake is not possible

 Exclusion Criteria:

 -  moribund patient expected to die within 24 hours

 -  hypercalcaemia (total calcium >2.65 OR ion. calcium >1.35 mmol/l)

 -  severely impaired gastrointestinal motility (ileus, residual gastric volume > 400 ml)

 -  known history of recent kidney stones (≤ 1 year)

 -  known granulomatous diseases (tuberculosis, sarcoidosis)

 -  pregnancy