Surveillance of Metabolic Parameters in Patients With Colorectal Cancer
Surveillance of Metabolic Parameters in Patients With Colorectal Cancer
A prospective, single center, cohort study for surveillance of metabolic parameters in
 patients who will receive chemotherapy after surgical resection of colorectal cancer
Primary objective - Incidence of newly developed diabetes mellitus in patients with
 colorectal cancer after post-operative chemotherapy

 Secondary objective - Pre-operative incidence of diabetes and characteristics of metabolic
 parameters of patients with colorectal cancer; Incidence of developed poorly controlled
 glucose level in diabetic patients with colorectal cancer after post-operative chemotherapy;
 3-year recurrence-free survival according to status of diabetes and metabolic parameters;
 5-year recurrence-free survival according to status of diabetes and metabolic parameters
Inclusion Criteria:

 -  Who will get surgical resection for colorectal cancer

 -  Who has diagnosed with diabetes

 -  Who met the criteria for testing of diabetes in asymptomatic adult individuals

 -  Criteria for testing for diabetes in asymptomatic adult individuals

 -  overweight (BMI>25 kg/m2*) and have additional risk factors (physical inactivity,
 first-degree relative with diabetes, high-risk race/ethnicity (e.g., African
 American, Latino, Native American, Asian American, Pacific Islander), women who
 delivered a baby weighing 0.9 lb or were diagnosed with GDM, hypertension
 (>140/90 mmHg or on therapy for hypertension), HDL cholesterol level ,35 mg/dL
 (0.90 mmol/L) and/or a triglyceride level >250 mg/dL (2.82 mmol/L), women with
 polycystic ovarian syndrome, HbA1C >5.7%, IGT, or IFG on previous testing, other
 clinical conditions associated with insulin resistance (e.g., severe obesity,
 acanthosis nigricans), history of CVD)

 Exclusion Criteria:

 -  Previously exposed to surgery or chemotherapy for colorectal cancer

 -  Second primary malignancy (except in situ carcinoma of the cervix or adequately
 treated basal cell carcinoma of the skin or prior malignancy treated more than 5 years
 ago without recurrence

 -  Presence of CNS metastasis

 -  Not able or willing to give informed consent

 -  Any patients judged by the investigator to be unfit to participate in the study