Metoclopramide-Ondansetron vs. Metoclopramide Therapy for Treatment of Nausea and Vomiting Post Laparoscopic Surgery
Metoclopramide-Ondansetron vs. Metoclopramide Therapy for Treatment of Nausea and Vomiting Post Laparoscopic Surgery
The incidence of postoperative nausea and vomiting (PONV) after general anesthesia is up to
 30% when inhalational anesthetics are used with no prophylaxis. This makes PONV one of the
 most common complaints following surgery under general anesthesia, together with
 postoperative pain.
This is a prospective, randomized, double-blind controlled clinical trial. Written informed
 consent will be obtained from patients. Patients will be randomly assigned using the sealed
 envelope technique into 2 equal groups:

 Group 1: Patients will receive 10 mg metoclopramide with 4mg ondansetron before induction of
 general anesthesia.

 Group 2: Patients will receive 10 mg metoclopramide before induction of general anesthesia.
Inclusion Criteria:

 -  Patients aging 16 years and above

 -  Patients undergoing laparoscopic cholecystectomy under General Anesthesia at Makassed
 General Hospital

 Exclusion Criteria:

 -  Patients with history of motion sickness

 -  Patients on previous treatment by anti-emetics for dizziness, vertigo or other causes
 of nausea and vomiting

 -  Patients with any type of allergy to metoclopramide or ondansetron

 -  Patients refusing to be part of the study (refusal to sign consent)

 -  Patients on previous treatment by opioids