Hypoglycemia Associated Autonomic Failure in Type 1 Diabetes Mellitus
Hypoglycemia Associated Autonomic Failure in Type 1 Diabetes Mellitus
The purpose of this study is to determine what corticosteroid receptor (and the dose of) is
 responsible for cortisol inducing hypoglycemia associated autonomic dysfunction in Type 1 DM.
 Specifically, we aim to determine whether stimulating the type 1 corticosteroid receptor (via
 fludrocortisone), the type 2 corticosteroid receptor (via dexamethasone), or both causes
 hypoglycemia associated autonomic dysfunction in Type 1 DM.
Inclusion Criteria:

 -  16 (8 males, 8 females) Type 1 diabetic patients aged 18-45 yr.

 -  HbA1c > 7.0%

 -  Had diabetes for 2-15 years

 -  No clinical evidence of diabetic tissue complications

 -  16 (8 males, 8 females) Healthy volunteers aged 18-45 yrs.

 -  Body mass index < 27kg · m-2

 Exclusion Criteria:

 -  Prior or current history of poor health

 -  Abnormal results following blood and physical examination

 -  Pregnancy