Senofilcon A Lenses in Moderate to Severe Dry Eye Disease
Senofilcon A Lenses in Moderate to Severe Dry Eye Disease
A clinical trial using Senofilcon A daily lenses in the treatment of moderate to severe dry
 eye. This a comparison between signs and symptoms prior to and during treatment.
32 patients with moderate to severe dry eye will be enrolled in this short-term proof of
 concept study to determine the efficacy in using soft lenses made of Senofilcon A in reducing
 signs and symptoms.
Inclusion Criteria:

 -  Confirmed diagnosis of moderate to severe dry eye associated with either
 Graft-versus-host disease (GVHD), Sjogren syndrome, idiopathic dry eyes, or minimal
 limbal cell deficiency

 -  A baseline Schirmer tear test (1) of less than 5 mm at 5 minutes without anesthesia

 -  Have a visual analog score for comfort of 50 or less (scale of 1-100, with 100 meaning
 perfect ocular comfort and 1 meaning severe ocular pain)

 -  Ability or the resources to insert and remove the study lenses

 -  An OSDI score greater than 42

 -  A willingness to sign an informed consent

 Exclusion Criteria:

 -  No dry eyes or mild dry eyes

 -  A baseline Schirmer tear test (1) of greater than 5 mm of wetting at 5 minutes

 -  Dry eye comfort score of greater than 50 on a visual analog scale

 -  Unable to insert or remove the study lenses (or have a family member do so)

 -  Have an OSDI score less than 42

 -  Has been diagnosed with neurotrophic keratopathy in either eye

 -  Unwilling to enroll in the study, and unwilling to provide signed informed consent to
 participate in the study