Conventional or Unconventional Lymph Node Dissection During Resection of Intrahepatic Cholangiocarcinoma
Conventional or Unconventional Lymph Node Dissection During Resection of Intrahepatic Cholangiocarcinoma
The aim of this study is to compare the surgical outcomes of conventional lymph node
 dissection with unconventional lymph node dissection during resection of Intrahepatic
 cholangiocarcinoma.
Intrahepatic cholangiocarcinoma (ICC) is one of the primary liver cancer, which has higher
 malignant, more difficult treatment and worse prognosis compared to hepatocellular carcinoma
 and its incidence continues to rise. The main radical treatment is surgical resection,
 however, postoperative recurrence rate is extremely high. The 3-year recurrence rate is more
 than 50%. It is reported that lymph node metastasis rate of ICC is as high as 20% to 65%,
 which is the most significant factor of the poor prognosis. The probability of lymph node
 metastasis is 13% when lymph nodes metastasis were not found preoperative or intraoperative.
 It is highly controversial whether or not to undergo conventional lymph node dissection when
 lymph nodes metastasis were not found preoperative or intraoperative . A number of
 researchers approved of lymph node dissection at that situation. However, some authors such
 as Kim suggest that lymph node resection is not necessary. Others such as Yang think should
 consider in different condition. Clark CJ thinks that the evidence for dissection or not of
 lymph node is insufficient in view of the above reasons, the investigators have planned to
 implement a randomized controlled study to confirm the prognostic value of conventional or
 unconventional lymph node dissection during resection of Intrahepatic cholangiocarcinoma.
Inclusion Criteria:

 -  Male or female patients > 18 years and <=70 years of age.

 -  Diagnosis of intrahepatic cholangiocarcinoma ( through imaging, serology,
 intraoperative frozen, etc.)

 -  No lymph node metastasis preoperatively or intraoperatively.

 -  Tumors can be completely resected.

 -  Criteria of liver function: Child A-B level, serum bilirubin ≤ 1.5 times the upper
 limit of normal value, alanine aminotransferase and aspartate aminotransferase ≤ 2
 times the upper limit of normal value.

 -  Patients who can understand this trial and have signed information consent. Exclusion
 Criteria:Lymph node metastasis preoperatively.

 -  Tumors can not be resected .

 -  Patients with apparent cardiac, pulmonary, cerebral and renal dysfunction, which may
 affect the treatment of Intrahepatic cholangiocarcinoma.

 -  Patients with a medical history of other malignant tumors.

 -  Subjects participating in other clinical trials.

 -  liver function:Child C.