Prevention of Gestational Diabetes
Prevention of Gestational Diabetes
Gestational diabetes mellitus (GDM)is a major health problem

 -  growing prevalence of obesity

 -  the older age of pregnant women

 A randomized controlled trial in 54 pregnant voluntary women at high risk for GDM.

 -  feasibility of an early intervention

 -  glucose tolerance at weeks 26-28
1. A 75-g oral glucose tolerance test (OGTT) was performed at weeks 8-12

 1. voluntary women in early pregnancy (n=96)

 2. 54 high risk mothers were randomized

 -  lifestyle intervention group (n=27)

 -  close follow-up (n=27)

 2. An OGTT was performed again at weeks 26-28

 -  the lifestyle intervention group (n=27)

 -  the close follow-up group (n=27)

 -  other high-risk women of the early care group (n=42)who were not randomized

 3. An OGTT was also performed at weeks 26-28 in two neighboring municipalities

 -  a standard care high-risk group(n=171)who did not undergo early intervention

 4. Primary outcomes

 -  number of at risk participants developing GDM during pregnancy in the two arms

 5. Secondary outcomes

 -  the effect of intervention on fetal growth
Inclusion Criteria:

 -  high risk for gestational diabetes

 -  fasting glucose 4.8-5.5 mmol/l and 2-hour glucose of OGTT <7.8 mmol/l

 Exclusion Criteria:

 -  normal glucose tolerance at weeks 8-12

 -  gestational diabetes at weeks 8-12