Functional and Morphologic MRI in the Detection of Prostate Cancer in Patients With Prior Negative Biopsy
Functional and Morphologic MRI in the Detection of Prostate Cancer in Patients With Prior Negative Biopsy
Prostate specific antigen (PSA) and digital rectal exam (DRE) are used to screen for prostate
 cancer. Patients with abnormal DRE or elevated PSA undergo transrectal ultrasound guided
 biopsy (TRUS-Bx). There are some men who have a normal TRUS-Bx despite persistent elevated
 PSA and may harbor occult prostate cancer. The purpose of this study is to determine if MRI
 using an endorectal coil, and advanced MRI methods called H1 MR Spectroscopy (MRS) and
 Dynamic MR Perfusion Imaging (dMRI) can help identify and localize prostate cancer in these
 patients and direct repeat TRUS-Bx to the most suspicious location in the prostate gland. 100
 men, currently under observation with elevated PSA but negative TRUS-Bx will be enrolled in
 the study.
Prostate specific antigen (PSA) and digital rectal exam (DRE) are used to screen for prostate
 cancer. Patients with abnormal DRE or elevated PSA undergo transrectal ultrasound guided
 biopsy (TRUS-Bx). There are some men who have a normal TRUS-Bx despite persistent elevated
 PSA and may harbor occult prostate cancer. The purpose of this study is to determine if MRI
 using an endorectal coil, and advanced MRI methods called H1 MR Spectroscopy (MRS) and
 Dynamic MR Perfusion Imaging (dMRI) can help identify and localize prostate cancer in these
 patients and direct repeat TRUS-Bx to the most suspicious location in the prostate gland. 100
 men, currently under observation with elevated PSA but negative TRUS-Bx will be enrolled in
 the study.
Inclusion Criteria:

 -  prior ultrasound biopsy of prostate showing no cancer or only single microfocus of
 cancer

 Exclusion Criteria:

 -  contraindication to contrast enhanced endorectal coil MRI