PGI2 Induced Headache and Cerebral Haemodynamics in Healthy Volunteers
PGI2 Induced Headache and Cerebral Haemodynamics in Healthy Volunteers
Before , during and after intravenous administration of PGI2 we score/measure headache, rCBF,
 blood flow in middle cerebral artery and diameter of superficial temporal artery/radial
 artery and correlate that to known patophysiology of headache to see if PGI2 is involved in
 headache pathophysiology.
Inclusion Criteria:

 -  Healthy volunteers,

 Exclusion Criteria:

 -  Primary headache,

 -  headache on the day of investigation,

 -  Hypertension,

 -  hypotension,

 -  pregnant/nursing

 -  Daily intake of medication (except oral contraceptives)

 -  Cardiovascular or CNS disease

 -  Drug/Alcohol abuse

 -  Psychiatric disease