High Fiber Rye Foods for Weight and Body Fat Reduction
High Fiber Rye Foods for Weight and Body Fat Reduction
The overall aim of this study is to investigate whether a diet rich in rye fiber from
 wholegrain rye, compared to refined wheat, as part of a hypocaloric diet leads to larger
 weight loss and lower body fat content after 12 weeks of intervention. Furthermore the study
 will investigate the effect on appetite as a potential underlying mechanism for differences
 in weight loss and body fat reduction.
Inclusion Criteria:

 -  BMI 27-35 kg/m2

 -  Hb≥120g/l

 -  Serum thyroid stimulating hormone (TSH) ≤4.00 mIU/L

 -  Plasma low density lipoprotein cholesterol <5.3 mmol/L

 -  Plasma triglycerides ≤1.8 mmol/L

 -  Signed informed consent

 -  Freezer capacity for 2 weeks bread provision

 Exclusion Criteria:

 -  Blood donation or participation in a clinical study with blood sampling within 30 days
 prior to screening visit and throughout the study

 -  Unable to complete satisfactorily the 3-day weighted food record at screening visit 2.

 -  Unable to lose 0.5 kg or more during the run-in period for men and women not having
 menstruation during the run in period

 -  Increased body weight, despite reported adherence to dietary intake for women with
 menstruation during the run-in period.

 -  Using nicotine products on a daily basis (incl. chewing gum, patches, snus etc.)

 -  Using e-cigarettes (regardless of nicotine content)

 -  Following any weight reduction program or having followed one during the last 6 months
 prior to visit 1

 -  Diastolic blood pressure 105 mm Hg at visit 1

 -  Systolic blood pressure 160 mm at visit 1

 -  History of stomach or gastrointestinal conditions (Inflammatory bowel disease, Crohn's
 disease, malabsorption, colostomy, bowel resection, gastric bypass surgery etc.)

 -  More than 10 hours physical activity per week

 -  History of heart failure or heart attack within 1 year prior to screening

 -  Have type I diabetes

 -  Receiving pharmacological treatment for type II diabetes (treatments based on life
 style interventions are acceptable, as long as they are compatible with the study
 protocol)

 -  Previous gastrointestinal surgery

 -  Thyroid disorder

 -  History of drug or alcohol abuse

 -  Stroke or transient ischemic attack (TIA) within 1 year prior to screening

 -  Consumption of drugs aimed at weight management or drugs affecting body weight to a
 degree that is considered unsuitable for study participation by responsible physician
 (will be included in the list of allowed/disallowed medications)

 -  Pregnant or lactating or wish to become pregnant during the period of the study.

 -  Food allergies or intolerances

 -  Vegetarian (due to the standardized meals for appetite measurements)

 -  Unable to understand written and spoken Swedish

 -  Lack of suitability for participation in the trial, for any reason, as judged by the
 medical doctor or PI.