Fecal Microbiota Transplantation for the Treatment of Recurrent Urinary Tract Infections
Fecal Microbiota Transplantation for the Treatment of Recurrent Urinary Tract Infections
Recurrent urinary tract infections are quickly becoming a public health obstacle in our aging
 population. Almost 50% of women have at least one urinary tract infection in their lifetime;
 following this first infection, there is a 25-35% chance that she will have another infection
 in the subsequent 3-6 months. With each documented infection, a patient receives anywhere
 from a three to seven day course of antibiotics for treatment. Repeated courses of
 antibiotics often lead to the development of multi-drug resistant infections that are
 difficult to treat with our arsenal of oral medications. It is theorized that most, if not
 all, urinary tract infections are caused by bacteria from the gastrointestinal tract. If
 there is a generalized gut dysbiosis due to repeated courses of oral antibiotics, it will
 likely be difficult to ever adequately treat repeat urinary tract infections. This same
 theory led to the development and utilization of fecal microbiota transplantation in the
 treatment of refractory Clostridium difficile diarrhea. There are now several studies that
 have reported on the efficacy of fecal transplantation in the treatment of C.difficile
 infections as well as the correction of gut dysbiosis. Given this positive response in
 treatment of refractory infectious diarrhea, the investigators propose that the correction of
 gut dysbiosis can also treat refractory recurrent urinary tract infections. Therefore, the
 investigators propose this pilot study to determine the effectiveness of fecal
 transplantation in the treatment of refractory, recurrent urinary tract infections.
Inclusion Criteria:

 -  English speaking

 -  Meet criteria for recurrent urinary tract infections A. Each infection with bacterial
 colony count of greater than 100,000 AND B. 2 culture proven urinary tract infections
 within the preceding 6 months or culture proven urinary tract infections within the
 preceding 12 months

 -  Failed conservative management of recurrent urinary tract infections A. Completed
 6-month trial of Macrobid, Trimethoprim or Methenamine suppression OR B. Completed
 6-week series of intravesical instillations with DMSO or heparin/lidocaine

 Exclusion Criteria:

 -  Pregnant

 -  Managed with a colostomy

 -  Managed with a suprapubic catheter

 -  Known renal abscess

 -  Acute or chronic renal failure

 -  Cardiac disease

 -  Rectal prolapse or bleeding

 -  Colon surgery in preceding 12 months