Effect of Tumescent Lidocaine on Platelet Function
Effect of Tumescent Lidocaine on Platelet Function
The purpose of this study is to evaluate the effect of lidocaine, delivered into subcutaneous
 tissue for tumescent local anesthesia, on platelet activation following the tumescent
 liposuction.
The current research study is intended to examine this hypothesis by determining if tumescent
 lidocaine increases the results of a test which measures the volume of bleeding which occurs
 when a tiny standardized incision is made on the forearm. This test is the BA test. The
 investigators will do BA tests before and after infiltration of lidocaine in the form of
 tumescent local anesthesia for liposuction and then compare the differences of these BA test
 results.

 The purpose of the present research project is to study how platelet function after surgical
 trauma (liposuction) is affected by tumescent lidocaine. The investigators hypothesize that
 lidocaine, delivered in the form of tumescent local anesthesia, inhibits surgical
 trauma-induced platelet activation as measured by the in-vivo Klein Bleeding Area test
 (www.onlinePFT).

 The Klein Bleeding Area (BA) test is an extension of the classic Ivy Bleeding Time (BT) test.
 The BT test, an in-vivo test for an abnormal bleeding tendency, involves making a small
 standardized cut in the skin and measuring the duration of bleeding. The BA test has
 significantly more sensitivity and specificity than the BT Test.

 This research project is a dosage-response clinical trial in which the predictor variable is
 the milligram per kilogram (mg/kg) dosage of tumescent lidocaine and the response variable is
 the Bleeding Area (BA). A result indicating that tumescent lidocaine does indeed impair
 post-operative platelet function would justify a subsequent randomized clinical trial of
 tumescent lidocaine for preventing post-operative thromboembolism.
Inclusion Criteria:

 -  Patients who have requested tumescent liposuction

 -  Healthy adults

 -  ASA Class I, II, or III

 Exclusion Criteria:

 -  Known allergy to lidocaine

 -  younger than 18 years

 -  Positive serology for Hepatitis C, HIV

 -  Chronic fatigue Syndrome

 -  known bleeding disorder

 -  significant psychiatric problems

 -  History of seizures

 -  Clinically significant cardiac arrhythmia

 -  Conditions predisposing to surgical site infections

 -  Active bacterial infection

 -  taking drugs know to affect hemostasis