Is Bone Scintigraphy Necessary in cT1N0M0 GGO Non-Small Cell Lung Cancer?
Is Bone Scintigraphy Necessary in cT1N0M0 GGO Non-Small Cell Lung Cancer?
In this prospective one-arm observational study, bone scintigraphy will be performed in
 T1N0M0 NSCLC patients with GGO lesion and other low risk factors of bone metastasis. The
 occurrence rate of bone metastasis in these patients will be analyzed to evaluate the
 necessity of bone scintigraphy in cT1N0M0 NSCLC patients.
Skeletal is a common metastatic site in patients with non-small cell lung cancer. The
 incidence of bone metastases is about 20-30％ in NSCLC patients. According to the NCCN
 guidelines, early lung cancer patients should also undergo bone scan or PETCT before surgery
 to determine the presence of bone metastases. However, all of the above methods use
 radionuclide reagents as tracers, which pose health hazards to patients and their contacts,
 including medical personnel. A retrospective study conducted by our center showed that only
 0.95% of patients with cT1N0M0 non-small cell lung cancer had preoperative bone metastases.
 In patients with early stage lung cancer whose lesions are pure ground glass nodules, the
 probability of developing bone metastases is zero. The low risk factors for bone metastases
 from this retrospective study included preoperative examination of patients with CEA <5 ng/ul
 and no bone-related symptoms. In patients with primary NSCLC who underwent CEA <5 ng/ul
 preoperatively, no bone metastases occurred; in patients with negative bone-related symptoms,
 the incidence of bone metastases was only 0.18%. In the case of such patients, if the bone
 scan is performed, not only the potential damage to the patient is increased, but also the
 waste of medical resources and the burden on the patient from the perspective of health
 economics.

 Therefore, our center is expected to conduct this prospective one-arm observational clinical
 trial. According to the low-risk factors derived from retrospective studies, bone
 scintigraphy was performed in patients with GGO lesion and other low risk factors of bone
 metastasis, and the incidence of bone metastasis was obtained. The necessity of bone
 scintigraphy in cT1N0M0 NSCLC patients would be evaluated.
Inclusion Criteria:

 1. Patients who sign the informed consent form and are willing to complete the study
 according to the plan;

 2. Age 18-80 years old;

 3. ECOG score ≤ 2 points;

 4. CT shows that the main lesion is considered to be ground glass nodular lung cancer;

 5. Preoperative examination CEA <5ng/ul

 6. There are no bone related symptoms

 7. There is no obvious absolute surgical contraindication for preoperative examination.

 Exclusion Criteria:

 1. History of bone related diseases.

 2. History of other kinds of cancer