Selenium Treatment in Autoimmune Thyroiditis (AIT)
Selenium Treatment in Autoimmune Thyroiditis (AIT)
Selenium suppresses autoimmune destruction of thyrocytes and decreases titers of serum TPOAb
 in AIT patients. Older 4 clinical trials approved the efficacy of the daily dose of 200micg.
 It's believed that Se saturates the deficient stores of GPX so GPX saves the thyrocytes
 against to oxidative stresses. Although less than 70 micg/d is sufficient to maximize GPX
 activity, none of the authors tested the doses less than 200 micg/d. Our hypothesis was that
 If 100 micg/d can not suppress the TPOAb titers,it means autoimmune destruction can not be
 blocked by saturation of deficient stores of GPX solely and the mechanism of action requires
 more than repletion of deficient stores. It's important not only to estimate the optimal dose
 but to understand the mechanism of action. High dose therapy may also suppress TPOAb levels
 in Se-non-deficient AIT patients, if it is so, Se therapy may becomes the solely treatment
 modality which can suppress the autoimmunity in more than 400 million AIT patients. Because
 there've been no way to suppress autoimmune war and replacement of LT4 had been the only
 treatment modality for palliation. An other independent part of the study is to test the
 effect of Se in adolescent AIT patients.
Inclusion Criteria:

 -  Clinically approved AIT patients who do not use any medication other than LT4 to keep
 TSH in the lower half of normal range.

 Exclusion Criteria:

 -  Any kind of drug use other than LT4 or any kind of known pathology which may effect
 GIS absorption.