Efficacy of Antiviral Therapy After Radical Resection for Hepatitis B Virus-Related Hepatocellular Carcinoma
Efficacy of Antiviral Therapy After Radical Resection for Hepatitis B Virus-Related Hepatocellular Carcinoma
Most hepatocellular carcinomas are associated with hepatitis B virus, it is hypothesized that
 anti-viral treatment may be helpful in treating HBV-related hepatocellular carcinoma.
As we know, recurrence and metastasis could happen in hepatocellular carcinoma even after
 radical resection.One reason is that virus hepatitis B could be one factor contributing to
 the carcinogenesis of hepatocellular carcinoma.To investigated whether anti-viral therapy
 could improve the efficacy of radical resection of hepatitis B virus (HBV)-related
 hepatocellular carcinoma(HCC),we planed to conduct this clinical trial.
Inclusion Criteria:

 1. patients who did not receive antiviral therapy prior to the resection of
 hepatocellular carcinoma

 2. patients who underwent radical resection of HCC, and 1 month after surgery,dynamic
 computed tomography showed on lesion in the liver and no signs of extrahepatic
 metastasis.

 3. hepatitis B surface antigen should be positive before surgery HBV-DNA level between
 100000 copies/ml and 10000000copies/ml anti-HCV negative

 Exclusion Criteria:

 1. previous history of antiviral therapy

 2. a baseline serum alanine aminotransferase level 2.5 times the ULN or higher

 3. positive for anti-HCV or anti-HIV

 4. Child-Pugh classification B or C after surgery

 5. preexisting evidence of hepatic decompensation, including encephalopathy,ascites,a
 bilirubin level more than 2 times the ULN, or a prolonged prothrombin time of more
 than 3 seconds

 6. signs showing recurrence or metastasis oen month after surgery

 7. underlying cardiac or renal diseases