Efficacy and Safety of Angelica Gigas N. Extract on Improvement of Hyperglycemia
Efficacy and Safety of Angelica Gigas N. Extract on Improvement of Hyperglycemia
This study was conducted to investigate the effects of daily supplementation of Angelica
 gigas N. extract on improvement of Hyperglycemia .
This study was a 8 weeks, randomized, double-blind, placebo-controlled 2×2 cross-over design
 human trial. Twenty subjects were randomly divided into Angelica gigas N. extract or a
 placebo group. Fasting and postprandial glucose profiles during oral glucose tolerance test
 (OGTT) were assessed before and after the intervention.
Inclusion Criteria:

 -  Age 20-80 years with fasting glucose 100-125 mg/dL or 2 hour postprandial glucose
 140-199 mg/dl

 Exclusion Criteria:

 -  Weight less than 48 kg or weight decreased by more than 10% within past 3 months

 -  Hypoglycemic agent, Obesity medicine, Lipid lowering agent within past 6 months or
 Blood sugar, Obesity and Lipid improvement functional foods within past 2 weeks

 -  Treated with corticosteroid within past 4 weeks

 -  Severe cardiovascular disease(Mvocardial infarction, Stroke, etc)

 -  Renal disease(Heredity hyperlipidemia, Acute/Chronic renal failure, Nephrotic
 syndrome, etc)

 -  Rheumatoid arthritis, Autoimmune disease

 -  Cancer, Respiratory organ disease(Asthma, Chronic obstructive pulmonary disease)

 -  Allergic or hypersensitive to any of the ingredients in the test products

 -  History of disease that could interfere with the test products or impede their
 absorption

 -  Under antipsychotic drugs therapy within past 2 months

 -  History of alcohol or substance abuse

 -  Participation in any other clinical trials within past 2 months

 -  Laboratory test by show the following results

 -  aspartate aminotransferase, alanine aminotransferase > Reference range upper
 limit treble

 -  Serum Creatinine > 2.0 mg/dl

 -  Pregnancy or breast feeding

 -  Not Contraception(except: Surgery for female infertility)