The Study Will Evaluate the Effect of AZD9164 in Patients With Chronic Obstructive Pulmonary Disease
The Study Will Evaluate the Effect of AZD9164 in Patients With Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease (COPD) is a chronic respiratory condition with
 deteriorating lung function over the years. Patients with COPD experience symptoms of
 shortness of breath, cough and sputum production. This study is to assess the treatment
 effects after inhalation of three different single doses of AZD9164 (100, 400 and 1200 mcg)
 and one single dose of tiotropium (18 mcg). One dose of placebo will be given as comparator.
 25 patients are to participate in the study and all will be recruited in Sweden. Each patient
 will visit the study doctor 9 times during the study, whereof 5 visits will be overnight
 visits. All examinations, treatment and the follow-up is free of charge.
Inclusion Criteria:

 -  A clinical diagnosis of COPD

 -  FEV1 40 - 80% of the predicted normal value (post-bronchodilator) and post-
 bronchodilator FEV1/FVC < 70%

 Exclusion Criteria:

 -  Any clinically relevant abnormal findings at screening examinations

 -  Any clinically significant disease or disorder