SEACOAST 1- SEdAtion With COllAteral Support in Endovascular Therapy for Acute Ischemic Stroke
SEACOAST 1- SEdAtion With COllAteral Support in Endovascular Therapy for Acute Ischemic Stroke
SEACOAST 1 is a prospective, randomized, blinded endpoint trial comparing collateral vigor
 and clinical outcomes, with different forms of GA in patients with acute ischemic stroke due
 to anterior circulation large vessel occlusion (LVO) undergoing mechanical thrombectomy. The
 study compares GA with normocarbia (GAN) versus GA with mild hypercarbia (GAH), with a
 primary outcome of collateral robustness at measured at catheter angiography and clinical
 efficacy as secondary outcome. It is anticipated that the SEACOAST 1 will be followed by a
 larger, pivotal trial, SEACOAST 2, with primary clinical endpoints, in which the best method
 of GA identified in SEACOAST 1 is compared with the alternative strategy of anesthesia care
 (MAC) with minimal or no sedation. The current study focuses uppn SEACOAST 1, which is to be
 conducted in University of California, Los Angeles Ronald Reagan Medical Center and Santa
 Monica Medical Center. All acute stroke patients who arrive to one of these two stroke
 centers and are deemed eligible for thrombectomy will be considered for the proposed study.
 Physician-investigators will determine study eligibility. Informed consent to participate in
 the study will be obtained from legally authorized representatives or competent patients. For
 non-competent patients without on-scene legally authorize representatives, the consent
 process will utilize enrollment in emergency circumstances with exemption of informed consent
 (EFIC).
Study design:

 SEACOAST 1 is a prospective, randomized, blinded endpoint trial comparing collateral vigor
 and clinical outcomes, focusing on two distinct sedation strategies:

 1. General anesthesia with mild hypercarbia (GAH) during the sedation up until full
 revascularization versus

 2. General anesthesia with normocarbia (GAN) during the sedation up until full
 revascularization

 Neuroanesthesia protocol, focused on maintenance of baseline BP, avoidance of hypotension
 during induction, and targeted partial pressure of carbon monoxide (PCO2) levels (normocarbia
 or mild hypercarbia):

 -  Anesthesia must not delay target initiation of procedure (groin puncture) of 90 min from
 ED arrival

 -  Standard American Society of Anesthesiologists (ASA) monitoring: 5 lead ECG, end-tidal
 CO2 (ETCO2), Pulse oximeter, BP monitor, Body temperature per esophageal probe, ET gas
 analyser

 -  Neuromuscular block (NMB) monitor for depth of neuromuscular blockade

 -  Arterial line placement is encouraged if it can be inserted within 5 min. Otherwise
 noninvasive BP per cuff. If arterial line has not been placed prior to induction monitor
 noninvasive blood pressure (NIBP) every 1 min per cuff until arterial line becomes
 available.

 -  BP goals - keep at baseline with goal of no more than 10% drop (last recorded BP prior
 to induction) and cannot exceed 185/105 if patients received intravenous tissue
 plasminogen activator (IV TPA).

 *BP can be lowered to desired goal only after revascularization as deemed necessary by
 the neurointerventional physician

 -  Induction with propofol or etomidate and rocuronium 1.2 mg/kg or succinylcholine

 -  Short acting vasoactive drugs (Phenylephrine, Ephedrine, Esmolol, Clevidipine) should be
 readily available to maintain BP in the predefined range throughout procedure.
 Phenylephrine drip recommended to maintain BP

 -  Anesthesia maintenance with volatile anesthetic and fentanyl; doses to be titrated to BP
 per anesthesiologist

 -  Qualitative end-tidal CO2 (ETCO2) measurement

 -  Immediately upon groin puncture interventionalist will provide blood gas sample to test
 arterial C02

 A. Normocarbia arm:

 Controlled ventilation with PCO2 levels 40 (±5%)

 B. Mild hypercarbia arm:

 Controlled ventilation with PCO2 levels 50 (±5%)

 -  Normalize PCO2 levels to 40 (±5%) immediately after adequate revascularization (TICI 2B)

 -  Baseline arterial blood gas values for correlation/correction with PCO2 level detected
 on ETCO2 measurements

 -  Mandatory extubation attempt within 60 minutes after procedure completion. Reasons for
 failed extubation should be documented
Inclusion Criteria:

 1. Age 18-85

 2. NIHSS ≥ 6 within 0-16h or NIHSS ≥ 10 within 16-24h

 3. Anterior circulation large vessel occlusion (ICA, M1, M2)

 4. ASPECTS score ≥ 6 within the first 6h, or DEFUSE trial imaging criteria within 6-16h;
 or DAWN trial clinical/imaging mismatch criteria within 16-24h

 5. Premorbid modified Rankin Scale (mRS) 0-2

 6. Patient deemed candidate for mechanical thrombectomy with anticipated groin puncture
 within 24 hours of last known well and within 90 min of ED arrival

 Clinical Exclusion Criteria:

 1. Intubation in ED prior to anesthesiologist evaluation, or intubation for any other
 medical reason other than planned thrombectomy

 2. Rapid neurological improvement, suggestive of revascularization

 3. Known serious sensitivity to radiographic contrast agents.

 4. Current participation in another investigational drug or device treatment study.

 5. Renal Failure as defined by a serum creatinine > 2.0 mg/dl (or 176.8 μmol/l) or
 Glomerular Filtration Rate [GFR] < 30.

 6. Subject who requires hemodialysis or peritoneal dialysis, or who have a
 contraindication to an angiogram for whatever reason.

 7. Life expectancy of less than 90 days.

 8. Clinical presentation suggests a subarachnoid hemorrhage, even if initial CT or MRI
 scan is normal

 9. Subject with a co-morbid disease or condition that would confound the neurological and
 functional evaluations or compromise survival or ability to complete follow up
 assessments.

 10. Subject currently uses or has a recent history of illicit drug(s) or abuses alcohol
 (defined as regular or daily consumption of more than 4 alcoholic drinks per day.

 11. Septic or cardiogenic shock with severe life-threatening hypotension

 Imaging Exclusion Criteria:

 1. Computed tomography (CT) or Magnetic Resonance Imaging (MRI) evidence of acute
 intracranial hemorrhage on presentation.

 2. CT or MRI evidence of mass effect or intracranial tumor (except small meningioma).

 3. CT showing hypodensity or MRI showing hyperintensity involving greater than 1/3 of the
 middle cerebral artery (MCA) territory (or in other territories, >100 cc of tissue) on
 presentation.

 4. Baseline non contrast CT or DWI MRI evidence of a moderate/large core defined as
 extensive early ischemic changes of Alberta Stroke Program Early CT score (ASPECTS) <
 6

 5. CT or MRI evidence that ischemia is not in anterior circulation distribution.

 6. Imaging evidence that suggests, in the opinion of the investigator, the subject is not
 appropriate for mechanical thrombectomy intervention (e.g., inability to navigate to
 target lesion, moderate/large infarct with poor collateral circulation, etc.).

 Anesthesia exclusion criteria (relative):

 1. History of Malignant Hyperthermia

 2. History of allergic reaction/anaphylaxis to anesthetic drugs

 3. Inability to tolerate supine position (severe CHF)

 4. Chronic O2 dependence or any other known pulmonary condition that might lead to
 difficult extubation and prolonged mechanical ventilation including known pulmonary
 hypertension