Liver Injury by Statins in Patients With History of Hepatitis B Virus Infection
Liver Injury by Statins in Patients With History of Hepatitis B Virus Infection
The purpose of this study is to investigate the incidence of liver injury by statins in
 coronary heart disease (CHD) patients with history of hepatitis B virus (HBV) infection.
Inclusion Criteria:

 -  patients with CHD receive long-term statin treatment

 Exclusion Criteria:

 -  ALT is over ULN at baseline

 -  infection of Hepatitis A Virus, Hepatitis C Virus or Hepatitis E Virus

 -  triglyceride is over 4.5 mmol/L

 -  decompensated liver cirrhosis (Child B or C)

 -  active stage of HBV

 -  infection of Burkitt's lymphoma virus or cytomegalovirus, or other acute infectious
 disease

 -  congestive heart failure

 -  malignant tumor

 -  autoimmune disease

 -  receive other potential hepatotoxicity drugs such as immunosuppressant,
 antituberculotic and non-steroid anti-inflammatory drug.