Thermal Ablation of Cervical Metastases From Thyroid Carcinoma
Thermal Ablation of Cervical Metastases From Thyroid Carcinoma
This study will evaluate the clinical response and safety of ultrasound guided percutaneous
 thermal ablation of lymph node metastases from thyroid carcinoma as an alternative to
 surgical treatment.

 The ablation of cervical lymph node metastases from differentiated thyroid carcinoma or
 medullary thyroid carcinoma will be directed to lesions larger than 0.8 cm, using
 ultrasound-guided radiofrequency ablation (RFA), laser ablation (LA) or cryoablation (Cryo)
 techniques, randomly assigned. Clinical and ultrasound monitoring will be carried out during
 24 months, with examinations before the ablation procedure, immediately after including
 contrast-enhanced ultrasound (CEUS) when applicable, and B-mode, color Doppler and Shear-Wave
 elastography ultrasound follow up with 6, 12, and 24 months.
Thyroidectomy is the main treatment of well differentiated thyroid carcinoma. Residual or
 recurrent cervical metastases are common (9-20% of patients during long-term follow up).
 Thermal ablation of cervical metastatic lymph nodes from thyroid carcinoma has been proposed
 in research centers as an option for the treatment of patients who remain with metastatic
 disease in cervical lymph nodes, despite thyroidectomy with or without neck dissection
 associated with radioiodine treatment. Potential advantages from percutaneous thermal
 ablation are related to less complication rates, less morbidity, possibility of outpatient
 treatment modality, and less global treatment costs when compared to the surgical approach.

 Aims of the study:

 1. To evaluate safety and efficacy of ultrasound-guided thermal ablation in the treatment
 of cervical lymph node metastases from differentiated thyroid carcinoma

 2. To evaluate the best response to thermal ablation defined as lymph node reduction or
 volume stability after ablation

 3. To evaluate the CEUS patterns of lymph nodes before and after ablation

 4. To evaluate the elastography patterns of lymph nodes before and after ablation

 5. To evaluate the tumor marker response after ablation

 6. To evaluate the contribution of thermal ablation to decrease additional therapeutic
 procedures

 7. To compare differences between LA, RFA and cryoablation in terms of complications, side
 effects and tolerability

 Patients with cervical metastatic lymph nodes from differentiated thyroid carcinoma or
 medullary thyroid carcinoma who meet the eligibility criteria and who have been determined to
 be an appropriate candidate for local ablation therapy will be offered enrollment into the
 study. Patients agreeing to participate will become subjects of the study if they read and
 sign an informed consent form.

 Treatment will be performed using three different ablation technologies (laser ablation, RFA
 or cryoablation) in a randomly assignment fashion.

 Subjects will have up to six simultaneous treated lesions larger than 0.8 cm diameter with
 positive fine-needle aspiration biopsy. Ultrasound (and CEUS when applicable) will be
 performed over 24 months follow up in order to evaluate efficacy. Baseline and follow-up data
 will be collected for each subject via a web-based electronic data collection tool.

 In case of recurrent disease treated by any ablative technique in patients who did not
 undergo previous neck dissection, a rescue neck dissection will be performed; in case of
 recurrent disease treated by any ablative technique in patients who underwent previous neck
 dissection, a new ablative technique approach will be considered.
Inclusion Criteria:

 -  18 years of age or older

 -  Patients with fine needle aspiration biopsy (FNAb)-proven metastatic cervical lymph
 nodes at levels I, II, III, IV, V, VI or VII from differentiated thyroid carcinoma or
 medullary thyroid carcinoma who underwent total thyroidectomy and subsequent
 radioiodine therapy, in case of differentiated thyroid carcinoma.

 -  Patients considered high surgical risk candidate or patients who are informed about
 the ablation therapy and prefers it instead surgery;

 -  Patients with metastatic cervical lymph nodes over 0.8 cm diameter and under 4.0 cm
 diameter; no more than 6 simultaneous cervical nodal metastases;

 -  Cervical recurrences in previously lateral neck dissection patients for differentiated
 thyroid carcinoma or medullary thyroid carcinoma over 0.8 cm diameter.

 Exclusion Criteria:

 -  Age under 18 years

 -  Uncorrectable coagulopathy;

 -  Inconclusive or benign cytologic specimens;

 -  Pregnancy or breast-feeding;

 -  Anaplastic or poor-differentiated thyroid carcinoma;

 -  Partial thyroidectomy

 -  Cervical tumors not considered to surgery (invading vessels, nerves, larynx or
 trachea);

 -  Serious medical illness, including any of the following: uncontrolled angina,
 myocardial infarction, cerebrovascular event within 6 months prior to the baseline
 visit, uncontrolled congestive heart failure;

 -  Participation in other studies that could affect the primary endpoint