Short Period Incidence Study of Severe Acute Respiratory Illness
Short Period Incidence Study of Severe Acute Respiratory Illness
This is a multi-centre, prospective, short period incidence observational study of patients
 in participating hospitals and intensive care units (ICUs) with SARI. The study period will
 occur, in both Northern and Southern hemispheric winters. The study period will comprise a 5
 to 7-day cohort study in which patients meeting a SARI case-definition, who are newly
 admitted to the hospitals / ICUs at participating sites, will be included in the study. The
 study will be conducted in 20 to 40-hospital/ ICU-based research networks globally. All
 clinical information and sample data will only be recorded if taken as part of the routine
 clinical practice at each site and only fully anonymised and de-identified data will be
 submitted centrally.

 The primary aim of this study is to establishing a research response capability for a future
 epidemic / pandemic through a global SARI observational study. The secondary aim of this
 study is to investigate the descriptive epidemiology and microbiology profiles of patients
 with SARI. The tertiary aim of this study is to assess the Ethics, Administrative, Regulatory
 and Logistic (EARL) barriers to conducting pandemic research on a global level.
Severe acute respiratory infection (SARI) continues to be of major relevance to public health
 worldwide. In the last 10 years there have been multiple SARI outbreaks around the world. The
 2009 H1N1 pandemic was estimated to result in more than 200,000 respiratory deaths globally.
 The World Health Organization (WHO) defines SARI as an acute respiratory infection of recent
 onset (within 10 days) requiring hospitalisation, manifested by fever (≥38oC) or a history of
 fever and cough. There is international consensus that it is important to undertake
 observational studies of patients with SARI as an essential component of pandemic and
 epidemic research preparedness.
Inclusion Criteria:

 -  A history of feverishness or measured fever of ≥ 38 deg C;

 -  Cough;

 -  Dyspnoea (shortness of breath) OR Tachypnoea.

 Exclusion Criteria:

 • No exclusion criteria