Neuroinflammatory Response and Headache Control in Patients After Subarachnoid Hemorrhage
Neuroinflammatory Response and Headache Control in Patients After Subarachnoid Hemorrhage
The purpose of this study is to determine the relationship between the Neuroinflammatory
 response and headache pain after subarachnoid hemorrhage.
Persistent headache is a significant medical issue that affects 20% of patients who survive
 an aneurysmal subarachnoid hemorrhage (SAH). This headache may last years, severely affecting
 quality of life. Laboratory evidence suggests that the persistent headache may be a result of
 a maladaptive neuroinflammatory response to the hemorrhage injury that is more vigorous than
 necessary. The goal of this study is to measure key immunomodulators in the blood and the
 cerebrospinal fluid of these patients in order to determine the magnitude and dynamics of
 their neuroinflammatory response. In addition, the investigators will collect and analyze
 observational data about the success of medications to treat headache, with a specific focus
 on the anti-inflammatory agent dexamethasone, in managing acute headache pain and preventing
 the development of persistent headaches in patients after SAH.
Inclusion Criteria:

 -  Non-traumatic subarachnoid hemorrhage

 -  Age > 18 years

 -  Treated with external ventricular drainage

 Exclusion Criteria:

 -  Pregnancy or lactation

 -  Age < 18 years

 -  Traumatic SAH