Behavioral Activation With Depressed Adolescents
Behavioral Activation With Depressed Adolescents
Twenty percent of adolescents will have at least one episode of clinical depression by age
 18, and 65% will experience transient or less severe depressive symptoms. Depression
 compromises the process of adolescent development by interfering with academic, occupational,
 and social functioning, and increasing risk for substance use and suicide. Although initial
 research provides some support for both pharmacological and psychosocial interventions, many
 depressed teens do not respond to these interventions, and others experience a relapse of
 symptoms within one year. Furthermore, concerns about antidepressant medications increasing
 suicide risk have raised additional caution about use of pharmacotherapy with adolescents. As
 such, the importance of developing innovative treatment options for depressed adolescents is
 critical. Cognitive Behavioral Therapy (CBT) has been demonstrated to be effective in the
 treatment of depressed adults, with more modest efficacy data when used with children and
 adolescents. Interestingly, recent data from the adult literature suggests the positive
 outcomes of CBT can be achieved and surpassed by interventions that are purely behavioral in
 nature. Behavioral interventions may be easier to implement with many adolescents and may
 provide a better developmental fit for depressed adolescents. The present project proposes to
 develop a manualized Behavioral Activation (BA) Therapy for depressed adolescents, test its
 adaptability, acceptability, and feasibility in an open clinical trial with 12 adolescents
 (aged 12-17), and following further treatment refinement, test its efficacy in a randomized
 controlled trial of 50 adolescents (aged 12-17), in which 25 will be randomized to BA Therapy
 and 25 will receive "Treatment as Usual (TAU)." In this randomized controlled trial,
 depressed adolescents will receive 12-weeks of BA Therapy or TAU. Psychiatric and
 psychosocial functioning will be assessed at the beginning, middle, and end of treatment. A
 naturalistic follow-up will be conducted 4 and 9 months post-treatment. Assuming that BA will
 outperform "usual" approaches to therapy with depressed youth, the data will provide the
 basis for the development of a larger randomized controlled trial comparing the efficacy of
 BA against other widely studied approaches to the treatment of depression in youth, namely
 pharmacotherapy in the form of Selective Serotonin Reuptake Inhibitors (SSRIs), and CBT.
Inclusion Criteria:

 1. Age between 11 and 18;

 2. one parent/legal guardian willing to participate in the study;

 3. primary diagnosis of a depressive disorder (Major Depressive Disorder, Dysthymia,
 Depression NOS);

 4. Short Mood and Feelings Questionnaire >11;

 5. Children's Depression Rating Scale score > 45;

 6. willingness to be randomized into either treatment group.

 Exclusion Criteria:

 Adolescents will be excluded if they meet any of the following criteria:

 1. primary diagnosis other than a depressive disorder;

 2. presence of psychotic and/or manic symptoms;

 3. presence of chronic medical condition;

 4. presence of active substance abuse/dependence;

 5. presence of chronic self-mutilation or cutting (e.g., persistent, severe, and/or
 requiring medical treatment);

 6. presence acute or chronic suicidality (e.g., > 3 suicidal gestures in the past year),

 7. previous unfavorable response to an adequate regimen of either CBT or antidepressant
 treatment in the prior year, and/or (8)developmental delay.