A Study on the Gastrointestinal Disease and Helicobacter Pylori Controlled Long Non-coding RNA
A Study on the Gastrointestinal Disease and Helicobacter Pylori Controlled Long Non-coding RNA
Helicobacter pylori (H.pylori) is a major human pathogenic bacterium in gastric mucosa which
 is linked to the development of gastritis, peptic ulcer disease, mucosa-associated lymphoid
 tissue lymphoma and gastric cancer. However the regulatory mechanism of H.pylori-induced
 immune response is not clear. Long non-coding RNA (lncRNA) has recently emerged as key
 post-transcriptional regulators of gene expression, differentiation. The investigators had a
 preliminary results which THRIL (TNFα and hnRNPL related immunoregulatory lincRNA) and
 PACER(p50-associated COX-2 extragenic RNA) played a potential role in H.pylori induced
 inflammatory cascade. However, there wasn't a previous study about expression of THRIL, PACER
 in a human tissue. Therefore, the investigators aimed to evaluate the expression of THRIL,
 PACER in patients with gastrointestinal disease according to H.pylori infection.
Inclusion Criteria:

 1. Over 19 years old

 2. Patients with gastric ulcer

 3. Patients with duodenal ulcer

 4. Patients with stomach cancer

 5. Patients with gastrointestinal discomfort symptoms

 Exclusion Criteria:

 1. Patients who has done helicobacter pylori eradication

 2. Patients who has undergone gastrectomy

 3. Patients who has undergone endoscopic submucosal dissection

 4. Patients with active upper gastrointestinal bleeding