A Prospective Cohort of Pulmonary Ground Glass Nodules Patients With Family History.
A Prospective Cohort of Pulmonary Ground Glass Nodules Patients With Family History.
The aim of the present prospective cohort study (GGN-F) is to study the family aggregation of
 pulmonary ground glass nodules via the questionnaire survey and to investigate the underlying
 genetic mechanism via the biobank.
In recent years, with the development of low-dose chest CT screening, more and more ground
 glass nodules have been found. Meanwhile, presenting as Ground-glass nodule (GGN), the
 early-stage lung adenocarcinoma patients with lung cancer family history have been emerging
 increasing in recent years in East Asian.

 This prospective cohort study, with both a cross-sectional and a longitudinal part, will
 include patients with pulmonary ground glass nodule, which were proven malignant disease.

 All participants will be asked to complete questionnaire to build the clinical database of
 GGN patients with detailed family history. Furthermore, blood and surgical tumor samples will
 be collected as a specific biobank. And the blood samples of other family members of
 participants will be collected, with their consent and knowledge.
Inclusion Criteria:

 1. patients with informed consent;

 2. patients with pulmonary ground glass nodule.

 3. pathological proved early stage lung cancer.

 Exclusion Criteria:

 1.not included in the inclusion criteria