Familial and Environmental Factors Behind Migraine
Familial and Environmental Factors Behind Migraine
Migraine is a chronic neurological disease characterized by recurrent moderate to severe
 headaches often in association with a number of autonomic nervous system symptoms. Migraines
 are believed to be due to a mixture of environmental and genetic factors. About two-thirds of
 cases run in families. Changing hormone levels may also play a role, as migraines affect
 slightly more boys than girls before puberty, but about two to three times more women than
 men after puberty. The risk of migraines usually decreases during pregnancy. The exact
 mechanisms of migraine are not known. It is, however, believed to be a neurovascular
 disorder. The primary theory is related to increased excitability of the cerebral cortex and
 abnormal control of pain neurons in the trigeminal nucleus of the brainstem.
Environmental influences play a role, but family studies suggest that defective genes may be
 primarily involved in disease causation. The mode of transmission of typical migraine in
 families is still unclear, but it is widely believed to be multifactorial although a role for
 a major susceptibility gene cannot be excluded. Aim of study: we aim to study the familial
 risk for developed migraine and its relation to EEG changes.
Inclusion Criteria:

 -  Fullfilled Migraine chriteria

 Exclusion Criteria:

 -  Genereal Neurologic Disease