Swelling Management After Total Knee Arthroplasty
Swelling Management After Total Knee Arthroplasty
The purpose of this feasibility study is to estimate the initial efficacy and feasibility of
 an inelastic compression garment donned immediately after TKA on peak swelling in 14
 subjects.
Total knee arthroplasty (TKA) is the most commonly performed surgical procedure in older
 adults and is expected to increase five-fold by 2040 to 3.5 million TKAs annually. Although
 TKA is effective at reducing pain and improving self-reported quality of life, postoperative
 knee swelling after TKA is profound with the average level of swelling peaking at a 35%
 increase in the first 6-8 days after surgery and persisting months after surgery.
 Postoperative swelling is associated with a 60% decrease in quadriceps strength in the first
 month after surgery leading to decreases in functional performance of up to 90%. Patients can
 exhibit chronic strength deficits on the order of 28-42% based on comparisons with
 age-matched controls years after surgery. Quadriceps weakness results in long-term decreases
 in gait speed, balance, stair-climbing ability, chair rise ability, increased risk for falls
 and disability later in life. Additionally, postoperative knee swelling has also been
 associated with increased pain, decreased range of motion (ROM) and post-surgical
 complications such as deep venous thrombosis (DVT) and infection. Traditional postoperative
 interventions such as elastic compression stockings (e.g., thromboembolism-deterrent (TED)
 hose) have demonstrated minimal effectiveness in reducing swelling after TKA. We have
 demonstrated in a preliminary study (N=16) that an inelastic, adjustable compression garment,
 commonly utilized to manage patients with chronic lymphedema, can decrease postoperative
 cumulative swelling by 50% in the early postoperative period. With this data, the garment was
 not applied until postoperative day 4 and thus it had minimal effect on the peak swelling
 noted after surgery. Peak swelling, not cumulative, is associated with strength and function
 after TKA. Therefore, this feasibility study aims to mitigate peak swelling by donning the
 compression garment immediately after surgery in the operating room. It also seeks to assess
 the feasibility of the intervention from the subjects' perspective.

 Specific Aim 1:

 Estimate the effect of immediate compression garment (ICG) on the primary outcome of swelling
 at 4 days and 1, 2, 3, and 6 weeks postoperative.

 Hypothesis: The ICG group will have less swelling at 4 days and 1, 2, 3, and 6 weeks
 postoperative compared to historical controls.

 Specific Aim 2:

 Determine the participant feasibility of ICG by assessing 1) satisfaction and 2) adherence.

 Hypothesis 3.1: Study participants will indicate acceptability of compression garment wear
 with a median score of at least 4/5 ("somewhat satisfied") on a 5-point Likert scale
 satisfaction survey.

 Hypothesis 3.2: An 80% adherence rate will be observed for compression garment wear as
 assessed by a patient log.
Inclusion Criteria:

 -  Scheduled to undergo a primary, unilateral total knee arthroplasty secondary to
 end-stage osteoarthritis

 Exclusion Criteria:

 -  Discharge to location other than home after surgery

 -  History of heart failure, lymphatic insufficiency, hepatic disease, pre-existing
 pitting edema, varicose vein ligation or any other condition associated with lower
 extremity swelling

 -  Unstable orthopedic conditions (besides OA/TKA) that limit function

 -  Other neurological, vascular, or cardiac problems that limit function or cause chronic
 lower extremity swelling

 -  No caregiver or inability to touch toes which can affect the ability to don/doff the
 compression garment

 -  Current smoker or history of substance abuse

 -  Surgical complication necessitating an altered course of rehabilitation

 -  Uncontrolled diabetes (hemoglobin A1c level >8.0)

 -  Body mass index >40 kg/m2