Hypoperfusion-hypodensity Mismatch for the Identification of Patients With Stroke Within 4.5 Hours
Hypoperfusion-hypodensity Mismatch for the Identification of Patients With Stroke Within 4.5 Hours
Intravenous thrombolysis is recommended within 4.5 hours of stroke onset. The aim of the
 study is to evaluate whether a hypodensity on native CT within the virtually entire area of
 hypoperfusion on perfusion CT, i.e. hypoperfusion-hypodensity mismatch, identifies patients
 within the time window of thrombolysis in a multicenter cohort. The investigators hypothesize
 hypoperfusion-hypodensity mismatch will identify patients ≤ 4,5 hours of symptom onset with
 >70% specificity and >85% positive predictive value.
Inclusion Criteria:

 -  acute ischemic stroke

 -  evidence of acute intracranial vessel occlusion (any supratentorial proximal or
 peripheral artery of the anterior cerebral artery, middle cerebral artery or posterior
 cerebral artery territory) by CT hyper dense thrombus and/or CTangiography vessel
 occlusion and/or by ischemic perfusion deficit

 -  evidence for acute ischemic perfusion deficit, i.e. acute symptoms attributable to
 ischemic CT perfusion lesion

 -  complete native CT and CTperfusion performed on admission

 -  sufficient CT and CTperfusion quality for judgement of acute ischemic hypodensity

 -  known time of symptom onset.

 Exclusion Criteria:

 -  None