Thyroid Hormone Replacement for Hypothyroidism and Acute Myocardial Infarction(ThyroHeart-AMI)
Thyroid Hormone Replacement for Hypothyroidism and Acute Myocardial Infarction(ThyroHeart-AMI)
Based on accumulating evidences showing that hypothyroid status is associated with poor
 prognosis among acute myocardial infarction (AMI) patients, the study is designed to evaluate
 whether replacement treatment with levothyroxine could have beneficial effects on patients
 with AMI and hypothyroidism. This is a multicenter prospective computerized-randomized trial
 stratified by ejection fraction with a 1:1 ratio to levothyroxine group or standard therapy
 group.
The primary hypothesis is that reversing the hypothyroid status with levothyroxine on top of
 standard therapy for AMI is safe and has beneficial effects on cardiac function, myocardial
 perfusion/metabolism and myocardial fibrosis.
Inclusion Criteria:

 1. Age 18 - 75, male or non-pregnant female;

 2. Is diagnosed acute myocardial infarction and received primary percutaneous coronary
 intervention (PCI);

 3. With presence of hypothyroid status (i.e., TSH >7.0 mIU/L and (or) fT3 <1.79 pg/mL);

 4. Is able to understand the objective of the trial, takes part voluntarily and signs the
 written informed consent form.

 Exclusion Criteria:

 1. Those who have participated in other drug or therapeutic equipment clinical trials but
 do not reach the main study endpoint time limit;

 2. Symptoms of severe heart failure (Killip Class III and above);

 3. Severely impaired renal function before surgery: serum creatinine > 2.0mg/dl;

 4. Impaired liver function before surgery: Serum GPT > 120U/L;

 5. Those who have prior thyroid diseases and already on levothyroxine or anti-thyroid
 medicines;

 6. Those taking medicine which can affect the test of thyroid function;

 7. Patients who plan to undergo coronary artery bypass grafting or other surgery within 3
 months;

 8. Those having prior myocardial infarction;

 9. Patients who are deemed by the researchers to have low compliance and unable to abide
 by the requirements and complete the study.