Impacts of Metabolic Variation on Neuroendocrine Control of Reproduction
Impacts of Metabolic Variation on Neuroendocrine Control of Reproduction
This study will evaluate the potential effects of a changing metabolic environment on GnRH
 hypothalamic neurons, by performing studies of LH pulsatility (basal and during clamp
 studies) in different groups of male subjects fed isocaloric and hypercaloric diets. The
 participation of other gastro-intestinal tract hormones to these regulations will be
 systematically evaluated.
Inclusion Criteria:

 -  male

 -  age between 18 and 25 years old

 -  no known pathology

 -  normal physical exam

 -  BMI between 20 and 25 kg/m2

 Exclusion Criteria:

 -  history of endocrine disease

 -  no known infertility (no conception after 12 months of regular unprotected
 intercourse)

 -  abnormal results on the initial blood tests (CBC, fasting glucose and insulin, HbA1C,
 TSH, free T4, LH, FSH, inhibin B and total testosterone)