Black Cohosh Extract for the Management of Moderate to Severe Menopausal Symptoms in Thai Women
Black Cohosh Extract for the Management of Moderate to Severe Menopausal Symptoms in Thai Women
Cimicifuga racemosa (black cohosh) rhizome and root extract have been used to treat
 menopausal symptoms. To date, there are still scarce information about its efficacy in Thai
 women with menopausal symptoms. The purpose of this study will assess the efficacy of black
 cohosh extract in management of menopausal symptoms in Thai women.
Inclusion Criteria:

 -  Thai women, aged ≥ 40 years

 -  Peri- or postmenopause

 -  Moderate to severe menopausal symptoms from Kupperman menopausal index score at least
 20

 Exclusion Criteria:

 -  Using any drugs or hormonal treatment within 1 month before enrollment

 -  BMI ≥ 30 kg/m2

 -  Allergic to drugs or any ingredient

 -  Liver disease or AST ≥ 37 U/L or ALT ≥ 40 U/L or total bilirubin ≥ 1 mg/dL or direct
 bilirubin ≥ 0.3 mg/dL

 -  Psychiatric disease

 -  Alcohol consumption or any elicit drug use

 -  Vegetarian (may consume more phytoestrogen)