Effect of Local Administration of Morphine for Analgesia After Iliac Bone Graft Harvest
Effect of Local Administration of Morphine for Analgesia After Iliac Bone Graft Harvest
The goal of the current study was to evaluate the analgesic efficacy of low-dose morphine
 administered to the site of bone graft harvesting in patients undergoing orthopedic surgery.
 In addition to short-term analgesic effects, the incidence of chronic donor site pain was
 evaluated 1,3,6 m after surgery.
The protocol is approved by the Institutional Review Board at Gülhane Military Medical
 Academy Haydarpaşa Training Hospital (Istanbul, Turkey) and written informed consent will be
 obtained from each patient. Sixty adult patients scheduled to undergo elective upper
 extremity bone fractures using autogenous bone grafts will be enrolled in this prospective,
 randomized, double-blind study. Patients were eligible for participation if they were greater
 than 18 yr of age, they weighed more than 40 kg, they were American Society of
 Anesthesiologists physical status I or II, and they could operate a patient-controlled
 analgesia (PCA) device and had no allergies to morphine.

 All surgical procedures will be performed using a partial thickness posterior iliac crest
 bone graft harvested through a lateral oblique incision just cephalad to the crest.
 Anesthesia was induced with 2 mg/kg propofol and 5 mg/kg fentanyl and maintained with
 sevoflurane in 50% oxygen in air. After the graft was harvested and hemostasis will be
 achieved, patients will be randomly assigned to one of three treatment groups using a
 computer- generated random number table. Group 1 (control group) was given 10 ml normal
 saline (NS) infiltrated into the harvest site, and 1 ml NS was administered intramuscularly.
 Group 2 (intramuscular morphine) was given 10 ml NS infiltrated into the harvest site and 5
 mg morphine (1 ml) intramuscularly. Group 3 (donor site morphine) was given 5 mg morphine (10
 ml) infiltrated into the harvest site and 1 ml NS intramuscularly. All intramuscular
 injections were administered in the deltoid muscle at the same time as harvest site
 infiltration. The study medications were prepared by the pharmacy and administered by the
 surgeon and anesthesiologist, who were blinded to their contents. In the recovery room,
 patients were connected to a PCA pump (Abbott PCA Plus, Abbott Laboratories, North Chicago,
 IL) containing 1 mg/ml morphine. The initial settings were an incremental dose of 1.5 ml, a
 lockout interval of 8 min, and a 4-h limit of 30 ml. The incremental dose was increased to
 2.0 ml and the 4-h limit was increased to 45 ml if analgesia was inadequate after 1 h. If
 analgesia was inadequate after an additional hour, the incremental dose was further increased
 to 2.5 ml. Patients were asked to quantify their pain from both the donor and the upper
 extremity surgery incision sites on a verbal analog pain scale of 0-10, with 0 representing
 no pain and 10 the worst imaginable pain. Pain assessments were made by a blinded research
 nurse observer 2, 4, 6, 8, 12, and 24 h after completion of surgery. In addition, PCA
 morphine use was recorded at these six time intervals. Analgesic duration was defined as the
 time from local administration of study drug to the first requirement of PCA morphine. At 1m,
 3 m and 6 m yr after surgery, patients will be interviewed by telephone by a blinded
 investigator, and a detailed questionnaire similar to that reported in a previous study on
 donor site pain will be completed. The presence and subjective characteristics of any
 residual donor site pain, including its quality, severity, and frequency, as well as
 provoking factors and treatment received, will be recorded.
Exclusion Criteria:

 -  Patients on opioids

 -  Neuropathic disease

 -  Chronic conditions