Efficacy of Pancrelipase on Postprandial Belching and Bloating.
Efficacy of Pancrelipase on Postprandial Belching and Bloating.
The hypothesis of this study is that the administration of pancrelipase with meals will
 benefit symptoms of post-prandial bloating, pain and eructation.
Subjects will complete a double-blind crossover study in which, for one week periods, they
 will receive two pancrelipase tablets with each of the three major meals or a similarly
 administered identical placebo. Three times daily, subjects will rate the severity of
 belching, epigastric discomfort, epigastric fullness, bloating, and nausea.
Inclusion Criteria:

 -  Subjects will have either bothersome upper abdominal discomfort, bloating (feeling of
 abdominal distention) or belching following meals for at least 12 month's duration.
 Subjects must have had a normal upper gastrointestinal endoscopy and/or upper GI
 series during the preceding three years.

 Exclusion Criteria:

 -  Individuals with a history suggestive of organic disease such as recent weight loss,
 nausea, vomiting, GERD, recent changes in bowel habits will be excluded from the
 study.