Head Out Water Immersion for Hemodynamic Stability During Dialysis
Head Out Water Immersion for Hemodynamic Stability During Dialysis
Immersion to the neck before and during hemodialysis session may increase intravascular
 volume, potentiate the ability to ultrafiltrate excess water, with less symptoms of shock,
 muscle crumps etc.

 The aim of the present study is to compare blood volume, hemodynamic and endocrine parameters
 of chronic ESRD patients undergoing forth dialysis session in water immersion vs. control
 regular session.
10 chronic hemodialysis patients, treated in the hemodialysis unit of Asaf-Harofeh Medical
 Center will be enrolled in the study.

 Hemoglobin and albumin will be detected at baseline, and a recent (less than one year) echo
 will be used for the detection of ejection fraction.

 The study will be a cross over study. Each set of studies will consist of two dialysis
 sessions, an immersion session, and a dry, non-immersion session. The study sessions will be
 short, 3 hours sessions with 250-350 ml/min blood flow (depends on the patients access)
 dialysate flow was 500 ml/min and dialysate sodium was 137meq/l. The temperature of the
 dialysate will be adjusted to 37°C and its composition as follows: Na+ = 137 mEq/L, K+ = 2.0
 mEq/L, Ca2+ = 3.0 mEq/L, Mg2+ = 1.0 mEq/L, HCO3-= 30 mEq/L, glucose =100 mg/dL, CH3COO-= 8
 mEq/L. The sodium concentration will be constant during treatment.

 Ultrafiltration will be determined as the mean of UF during the ten previous sessions±10%
 according to the patients weight on admission. The immersed and dry session will be done in
 the midweek sessions, in random order, at least one week apart from each other.

 Head-Out Water Immersion

 A bath will be used for immersion. The bath will be filled with purified water before each of
 the session, and will be heated to 34-35°C. Patients will enter the bath and sat upright for
 few minutes and then connected to dialysis. The water will circulate through a thermostats
 and heating device in order to maintain a constant temperature.

 Patients with arterio-venous fistula or graft in their arm will be immersed in water up to
 their axilla, with their arm lining on a floating pad. For patients with perm-cath immersion
 will only be done up to 5 cm below the catheter insertion.

 Study procedure

 Subjects will enter the bath and sit for few minutes, after which blood samples will be drown
 for baseline measurement. During the session blood pressure and heart rate will be measured
 every 15 minutes by conventional sphygmomanometry. and blood volume will be estimated by
 using blood volume monitor (Crit-Line).

 Blood samples will be drown at baseline and after one hour, and before caseation of the
 session for plasma renin activity, aldosterone, atrial natriuretic peptide. Baseline and end
 of session urea will also measured for URR.
Inclusion Criteria:

 -  chronic hemodialysis patients

 Exclusion Criteria:

 -  anemia (HB<10) active infectious disease cognitive impairment dialysis access
 installed in the leg inability to cooperate with the study procedure Clinically
 evident overhydrated patients(edema, pulmonary congestion, pulmonary effusion)