A Registry of Tuberculosis Cases in the CPCRA
A Registry of Tuberculosis Cases in the CPCRA
PRIMARY: To estimate the proportion of tuberculosis patients in the CPCRA who have
 drug-resistant tuberculosis (TB) and to describe the patterns of drug resistance.

 SECONDARY: To compare drug resistance data on the Mycobacterium tuberculosis isolates of
 HIV-infected patients to those of HIV-uninfected patients who are being followed in the
 CPCRA. To assess the relationship of resistance data with geographic, demographic, and HIV
 and TB risk factor information.

 Geographic areas and demographic subgroups affected by the TB epidemic appear to be congruent
 and associated with the concurrent HIV epidemic. The total number of CPCRA patients who will
 develop, or who have experienced, confirmed TB is unknown. It is critical to determine the
 depth and breadth of the current problem of drug-resistant TB.
Geographic areas and demographic subgroups affected by the TB epidemic appear to be congruent
 and associated with the concurrent HIV epidemic. The total number of CPCRA patients who will
 develop, or who have experienced, confirmed TB is unknown. It is critical to determine the
 depth and breadth of the current problem of drug-resistant TB.

 For both retrospective and prospective components of the study, demographic, geographic, HIV
 and TB risk factor information will be collected on CPCRA patients with confirmed pulmonary
 or extrapulmonary TB. Mycobacterial culture results will be recorded. Retrospective data will
 be collected on CPCRA patients with confirmed tuberculosis who have been diagnosed since
 January 1992 until the time of site registration. Prospective data will be collected on CPCRA
 patients with confirmed tuberculosis diagnosed during the period of 1 to 2 years following
 site registration.
Patients must meet the following criteria:

 -  CPCRA patients with confirmed pulmonary or extrapulmonary TB. Confirmed clinical TB
 requires a positive culture for Mycobacterium tuberculosis.

 NOTE:

 -  There is no requirement that patients have HIV infection.