Natural History of Clostridioides Difficile Infection
Natural History of Clostridioides Difficile Infection
Aim: To investigate if host factors, such as composition and diversity of intestinal
 microbiota and/or genetic determinants, are associated with a higher risk of recurrence of
 Clostridioides difficile infection (CDI). To generate a predictive tool based on
 epidemiological, clinical, genetic and microbiologic variables aimed to identify patients at
 a higher risk of CDI recurrence in a context of optimized ICD management. Design: Multicenter
 prospective cohort study. Patients: Older than 18 years patients with CDI diagnosis, made by
 IDSA criteria, in the participant centers.

 Follow-up: A stewarship program aimed to improve CDI management, including early detection of
 CDI recurrence, will be implemented in the participant centers. Blood samples for genetic
 testing and stool samples for intestinal microbiome studies will be collected.

 Variables and data analysis: The primary outcome variable will be the emergence of CDI
 recurrence. Potential independent predictors of recurrence, including genetic and
 microbiological factors, will be assessed. A predictive tool based on independent predictors
 of recurrence will be built in a development subpopulation. The performance of the model will
 be assessed by ROC curves, and sensititvity, especificity, as well as negative and positive
 predictive values will be calculated, both in the development subpopulation and in a
 validation subset.
Inclusion Criteria:

 -  Age older than 18 years

 -  New episode of Clostridioides difficile infection, based on IDSA criteria.

 Exclusion Criteria:

 - None