Effect of Anti-adhesion Barrier on the Voice Quality After Thyroidectomy.
Effect of Anti-adhesion Barrier on the Voice Quality After Thyroidectomy.
To determine whether the use of anti-adhesion barrier after thyroid surgery can prevent the
 voice changes after surgery, using objective voice-related indicators.
-  Randomized controlled study

 -  Including 40 patients in each arm

 -  Treatment: anti-adhesion barrier apply on the thyroidectomy space

 -  Control: No use of anti-adhesion barrier

 -  Primary outcome: VHI-30 (Voice handicap index)

 -  Secondary outcome: findings from stroboscopy, CSL (Computerize Speech Lab)

 -  Outcome measurement: preoperative, post-operative 3 months, post-operative 9 months.
Inclusion Criteria:

 -  Patients undergoing open thyroidectomy for thyroid cancer

 -  Patients whose tumor size is less than 4cm

 -  Patients who are not suspected of surrounding organ involvement (T4) or metastasis to
 central lymph nodes in preoperative imaging

 -  Patients with no history of voice-related diseases prior to surgery

 -  Patients with normal movement of both vocal cords in the preoperative vocal cord
 examination

 -  Patients who consented to the study and obtained consent for the study

 Exclusion Criteria:

 -  Patients with uncontrolled high blood pressure, diabetes, chronic renal failure,
 coagulation disease, etc.

 -  History of cardiovascular disease (angina pectoris, heart failure, myocardial
 infarction, cerebral infarction, cerebral hemorrhage, etc.)

 -  Medical history of drug or substance disorder (alcohol, etc.)

 -  Patients with diseases related to airways, esophagus, and vocal cords (vocal palsy,
 vocal cord polyps, etc.)

 -  Patients who have already had adhesions in the foreground due to radiation therapy or
 surgery on the foreground in the past.

 -  Patients with a history of keloid or hypertrophic scars

 -  Patients planning to perform lateral cervical lymph node dissection

 -  Patients with medical thyroid disease, such as Graves' disease and thyroid
 inflammation in need of treatment

 -  Pregnant or lactating female patients

 -  Other patients who are in charge of clinical trials as unsuitable for participation in
 the study