A Comparison of Two Treatments: Pacemaker and Percutaneous Transluminal Septal Ablation for Hypertrophic Cardiomyopathy
A Comparison of Two Treatments: Pacemaker and Percutaneous Transluminal Septal Ablation for Hypertrophic Cardiomyopathy
This study will compare two treatments: pacemaker implantation and percutaneous transluminal
 septal ablation (PTSA) for patients with hypertrophic cardiomyopathy (HCM), a condition in
 which the heart muscle thickens and obstructs the flow of blood out of the heart. The reduced
 blood flow can cause chest pain, shortness of breath, palpitations, tiredness,
 lightheadedness and fainting.

 Patients with HCM who cannot be helped by drug therapy may participate in the study. The
 standard treatment for such patients is septal myectomy, an operation in which the surgeon
 shaves the muscle obstructing the blood flow. Another treatment option is implantation of a
 type of pacemaker that causes the heart to contract in a certain way that reduces blood flow
 obstruction and improves symptoms. The pacemaker is implanted under local anesthesia and
 usually takes less than an hour. PTSA is an experimental treatment that may provide a third
 option. In PTSA, a thin tube (catheter) is inserted into the blood vessel that feeds the
 heart muscle causing the blood flow obstruction. A small amount of alcohol is injected
 through the catheter to destroy some of the muscle and relieve the obstruction.

 Candidates will have the following screening tests: chest X-ray, electrocardiogram,
 echocardiogram, exercise tests, exercise radionuclide angiography, exercise thallium
 scintigraphy, Holter monitoring, cardiac catheterization, electrophysiology study, and
 coronary angiography. Participants will be assigned to one of the two treatments groups:
 pacemaker implantation or PTSA. Patients in the PTSA group will also have magnetic resonance
 imaging scans at the start of the study, 3 to 7 days after PTSA, and at the end of the study,
 in order to observe changes in the heart's shape. All patients will fill out a questionnaire
 answering questions about their quality of life.

 Patients' progress will be followed with monthly phone calls. In addition, various tests,
 such as exercise tests and echocardiography, will be done during repeat visits at three and
 six months to measure treatment results. Patients will again complete quality-of-life
 questionnaires at both of those visits.
Patients with obstructive HCM and drug-refractory symptoms are referred for left ventricular
 myotomy and myectomy (LVMM) or mitral valve replacement. As alternative therapies to cardiac
 surgery, we propose to compare the abilities of dual chamber (DDD) pacing and percutaneous
 transluminal septal ablation (PTSA) to reduce left ventricular (LV) outflow pressure
 gradients and to improve exercise performance in patients with obstructive HCM and severe
 symptoms who have failed to benefit from pharmacotherapy.
Patients of either gender, aged 18-80 years.

 NYHA functional class III/IV, or syncope, or greater than or equal to 2 presyncope despite
 verapamil and/or Beta-blocker therapy.

 LV outflow tract gradient greater than or equal to 30 mm Hg at rest or greater than or
 equal to 50 mm Hg following isoproterenol infusion to a heart rate of greater than 100 bpm.

 No patients with mid-cavity obstructive HCM.

 No patients with LV septal wall thickness less than 15 mm estimated by echocardiography.

 No patients with greater than 50 percent luminal narrowing in a major coronary artery
 vessel.

 No patients with chronic atrial fibrillation.

 No patients with a positive pregnancy test.