Colposcopy and Dynamic Spectral Imaging (DSI)
Colposcopy and Dynamic Spectral Imaging (DSI)
This study evaluates the Dynamic Spectral Imaging (DSI) Colposcope (DySIS) in it's ability to
 diagnose cervical dysplasia. Half of participants with be examined by the DySIS colposcope,
 there the other half will be examined by standard colposcopy.
Colposcopy has been shown to be a subjective exam, and is dependant on the colposcopists.
 Sensitivity for colposcopy has been shown to be as low as 50%.

 To improve this, different adjunctive technologies have been introduced to add a more
 objective approach to the colposcopy exam. One of these devices is the DySIS colposcope,
 which measures the aceto-white reaction that may occur on the cervix uteri after the
 application of acetic-acid. The device provides the examiner with a colour-coded map
 indicating areas of interest. Studies have shown promising results indicating that using this
 device together with the colposcopists own interpretation of the cervix uteri can potentially
 lead to an increase in the performance of the colposcopy exam.

 In Denmark all women referred for colposcopy have 4 biopsies taken, according to the Danish
 national guidelines.

 In our study these 4 biopsies are as following:

 1. The area the colposcopists views as the worst before the DSI-map is seen.
 Colposcopy-Directed Biopsy (CDB)

 2. The area indicated as the worst by the DSI-map (DSI-directed biopsy)

 3. additional biopsy

 4. additional biopsy All biopsies are placed in separate containers and analysed separately
 by specialized pathologists.
Inclusion Criteria:

 -  Referred for colposcopy due to a cervical smear test of Atypical Squamous Cells of
 Undetermined Significance (ASCUS), low-grade intraepithelial lesion (LSIL), atypical
 squamous cells, cannot exclude a high-grade lesion (ASC-H), high-grade intraepithelial
 lesion (HSIL), Atypical glandular cells (ACG) or carcinoma in situ (CIS)

 -  Referred for colposcopy due to follow-up of previously diagnosed CIN (If there has
 been a minimum of 6 months since previous cervical biopsies)

 Exclusion Criteria:

 -  Cervical biopsies taken within the last 6 months

 -  Previous cone procedure

 -  Currently pregnant

 -  Pregnant within the last 6 months