Association of 5-HT3 Receptor Gene Polymorphism With the Efficiency of Ondansetron for Postoperative Nausea and Vomiting
Association of 5-HT3 Receptor Gene Polymorphism With the Efficiency of Ondansetron for Postoperative Nausea and Vomiting
Postoperative nausea and vomiting (PONV) is a common and distressing complication in patients
 undergoing general anesthesia. However, although 5-hydroxytryptamine type 3 (5-HT3) receptor
 antagonists have significantly reduced PONV, it is reported that over 35% of patients treated
 with ondansetron experience PONV. Though the cause of failure in ondansetron treatment is not
 clear, the investigators assumed that polymorphism in the 5-HT3 receptor gene would
 contribute to such inter-individual variation. In this study, the investigators examine
 whether the polymorphisms of 5-HT3 receptor gene affect the efficacy of ondansetron to
 prevent PONV in patients undergoing general anesthesia for laparoscopic surgery.
Inclusion Criteria:

 -  Adult patients (20-90 years of age) scheduled for undergoing laparoscopic surgery
 undergoing general anesthesia

 Exclusion Criteria:

 -  Patients with previous history of drug allergy,

 -  administration of antiemetic drugs within 24 hours,

 -  nausea/vomiting within 24 hours and liver or kidney disease