PST Linkage Based Analysis in the Family of More Than Two Members With Type 1 Diabetes in Taiwan
PST Linkage Based Analysis in the Family of More Than Two Members With Type 1 Diabetes in Taiwan
The purpose of this study is to explore the susceptible genes for Type 1 diabetes in Taiwan
 through the new genetic study methods.
As an unclear autoimmune disorder, the pathogenesis of type 1 diabetes (T1D) remains elusive.
 Among all the methods for studying diseases pathophysiology, genetic approach has valuable
 capability as being both hypothesis-testing and hypothesis-generating. Although
 geo-epidemiological studies show relatively higher prevalence of T1D in Caucasians than in
 Asians, whether genetic factors identified in T1D of Caucasians are essential for T1D in
 Asians is not yet clarified. Although the human leukocyte antigen (HLA) genotype variants
 have been reported to be associated with T1D, the odds ratio (ORs) is relatively low in
 Taiwan as comparing with western countries, some families are indeed more than one child with
 T1D. However, the genetic linkage study in T1D is still limited in Taiwan that hampered the
 drug development or research in T1D. Therefore, we intend to explore the susceptible genes
 for T1D of Taiwan in this study, which will provide further researcher directions for this
 disease.
Inclusion Criteria:

 1. Type 1 diabetes on the criteria of the American Diabetes Association with a very low
 C-peptide level (<0.35 ng/mL) with or without the experience of diabetic ketoacidosis.

 2. The subjects whose four grandparents are of Chinese Han origin

 Exclusion Criteria:

 1. Patients with ages of onset more than 35 years are excluded.

 2. The families having any member with known possible type 2 diabetes