Randomized Study for Patients With Follicular Lymphoma Needing Treatment
Randomized Study for Patients With Follicular Lymphoma Needing Treatment
2 parallel studies.

 -  For young patients (18-60 years): randomization between CHVP + interferon for 18 months
 and 4 CHOP followed by autotransplant after TBI

 -  For elderly patients (>60 years): randomization between CHVP + interferon for 18 months
 and fludarabine 5 days every months for 6 months
2 parallel studies.

 -  For young patients (18-60 years): randomization between CHVP + interferon for 18 months
 and 4 CHOP followed by autotransplant after TBI

 -  For elderly patients (>60 years): randomization between CHVP + interferon for 18 months
 and fludarabine 5 days every months for 6 months
Inclusion Criteria:

 -  study 1 (young patients): being less than 61 years old with a follicular lymphoma and
 needing to be treated because of high LDH level, high beta-2 microglobulin level, poor
 performance status, or large tumoral mass (lymph node >7 cm, symptomatic splenomegaly,
 pleura effusion, or sign of compression by the tumor mass)

 -  study 2 (elderly patients): being older than 60 years with a follicular lymphoma and
 needing to be treated because of high LDH level, high beta-2 microglobulin level, poor
 performance status, or large tumoral mass (lymph node >7 cm, symptomatic splenomegaly,
 pleura effusion, or sign of compression by the tumor mass)

 Exclusion Criteria:

 -  contra-indication to anthracycline or interferon

 -  transformation into large cell lymphoma

 -  previous treatment

 -  localized stage without criteria of large tumor mass

 -  patients HIV+