Evaluation of A New Digestive Reconstruction Procedure Following Pancreatoduodenectomy
Evaluation of A New Digestive Reconstruction Procedure Following Pancreatoduodenectomy
The purpose of this study is to evaluate the validity and safety of a modified operative
 procedure of digestive tract reconstruction following pancreatoduodenectomy which enables the
 pancreatic juice and bile to bypass at the pancreatointestinal anastomosis and merge at
 gastrointestinal anastomosis. It is anticipated that this procedure can decrease the risk of
 post-surgical pancreatic leakage and preserve the patients' digestive function as well.
Pancreatoduodenectomy (PD) is one of the most complicated surgeries in abdominal clinical
 practice. It is widely used in the treatment of pancreatic head carcinoma, periampullary
 carcinoma, chronic pancreatitis with intractable pain, pancreatic head mass which unable to
 rule out pancreatic cancer. PD was improved in many ways in the last 80 years and the
 post-surgical mortality has decreased under 5%. Since the resected region of PD is wide
 including gall bladder, billiary tract, duodenum, pancreas, stomach, jejunum and regional
 lymph nodes. It has a high prevalence of complications, of which pancreatic leakage is the
 most common and serious one with a prevalence rate of 5-25% and mortality rate 20-50%。 The
 objective of the present study is to evaluate a new surgical procedure used for the digestive
 tract reconstruction following PD. The new procedure enables the pancreatic juice and bile to
 bypass at the pancreatointestinal anastomosis and merge at gastrointestinal anastomosis which
 can decrease the risk of post-surgical pancreatic leakage and keep the digestive function of
 patients. A multicenter, randomized, controlled study is designed to observe the prevalence
 of pancreatic leakage, other post-surgical complications, hospital stay, medical costs, life
 quality and other indexes to evaluate the efficacy and safety of this procedure. It is
 anticipated that through the study, this new procedure can be systematically verified if it
 is an ideal procedure of digestive reconstruction following PD which can be promoted into
 wider use.
Inclusion Criteria:

 -  Below 80 years old

 -  CT (Computed Tomography), CTA (Computed Tomographic Angiography), MRI (Magnetic
 Resonance Imaging) or ultrasonic test suggested pancreatic head carcinoma,
 periampullary carcinoma, chronic pancreatitis with intractable pain, pancreatic head
 mass which unable to rule out pancreatic cancer, with or without obstructive
 jaundice/chronic abdominal pain.

 Exclusion Criteria:

 -  Liver Metastasis

 -  Metastasis in common bile duct and hepatic duct

 -  Extensive lymph node metastasis, metastasis at hepatic portal or above pancreas

 -  Pancreatic head or periampullary has tight adhesion with postcava or aorta

 -  Distant metastasis

 -  Poor physical condition to tolerate anesthesia and surgery (e.g. severe
 cardio-pulmonary diseases, blood coagulation disorders)