Study on Migraine and Headache in Epileptic Patients
Study on Migraine and Headache in Epileptic Patients
The purpose of this study is to collect data from patients who are diagnosed with epilepsy
 and are followed up in epilepsy clinics.
Headaches and epilepsy are chronic disorders with episodic manifestations characterized by
 recurrent attacks of nervous system dysfunction with a return to baseline between attacks.
 Although it is not uncommon that patients with epilepsy suffer from headaches, the relations
 between seizures and headaches is multi-factorial. Headaches may occur immediately before
 (preictal), during (ictal), or after (postictal) a seizure. In addition to seizure-associated
 headaches, patients often experience headaches that are not temporally related to
 seizures-interictal headaches. Moreover, epidemiological studies indicate an association of
 migraine and epilepsy with an increased prevalence of migraine in patients with epilepsy. Up
 to now, there is still limited information about the relationship between the frequency of
 seizure attacks and headache occurrences. Thus, we purpose this study to investigate the
 incidence of headaches, to explore the relationship between seizure attacks and headache
 occurrences, to classify the headache, and to document the frequency, characteristics, and
 effects of migraine and headaches among patients with epilepsy. This study is a multi-centre
 survey to collect data from patients who are diagnosed with epilepsy and are followed up in
 epilepsy clinics. Patients can only participate in this study after signing and dating the
 inform consents. There are two stages of this study: Stage I: On enrollment, data on
 demographic characteristics, epilepsy profile, seizure frequencies, and epilepsy treatment
 would be obtained. Body weight and height would be measured. Information of prior headache
 occurrences and their relationships with seizures would also be collected. Stage II: Patients
 enrolled into this study will be divided into three group: patients who are seizure free for
 past 6 months, patients with > 1 attack every month within past 6 months, and other patients.
 Participants of each group will be enrolled into Stage II for 24-week follow-up. Information
 of seizure attacks, headache occurrences, and treatment will be collected. This is an
 observational study and no study drug is administered.
Inclusion Criteria:

 -  Patients diagnosed with epilepsy

 -  Patients or parent(s)/caregiver(s) have signed and dated an informed consent.

 Exclusion Criteria:

 -  Patients who have non-epileptic events in addition to epilepsy, such as pseudoseizures
 or an acute symptomatic cause of seizures (e.g., a metabolic disturbance, toxic
 exposure, active CNS infection)

 -  Patients with progressive or degenerative neurological disorder

 -  Patients with an active malignancy

 -  Patients or parents/caregivers with known or suspected psychotic disease, mental
 retardation, or any mental situation which may cause the concern to properly complete
 this survey.