Comparing Two-time Points of Thyroid Hormone Replacement During the Holy Month of Ramadan
Comparing Two-time Points of Thyroid Hormone Replacement During the Holy Month of Ramadan
Muslims all over the world fast during the month of Ramadan from dawn until dusk. There is
 little data regarding the best timing of levothyroxine intake during the month of Ramadan
 where taking it on an empty stomach represents a challenge to most patients.This study aims
 to compare two-time points of levothyroxine intake during Ramadan in terms of change in
 thyroid stimulating hormone (TSH), compliance and convenience.
Hypothyroidism requires regular replacement with levothyroxine to achieve euthyroidism
 (thyroid hormone status within the normal range). Usually, levothyroxine is taken orally in
 the morning on a daily basis. In clinical practice, the investigators have observed that this
 levothyroxine replacement is sub-optimal resulting in higher levels of thyroid stimulating
 hormone. Based on this observation, the investigators conducted this study to examine whether
 timing of oral intake of levothyroxine during the holy month of Ramadan will affect
 achievement of euthyroidism. They recruited 96 hypothyroid patients taking levothyroxine,
 attending Hamad endocrine outpatient clinics, who were fasting during Ramadan( May-June
 2017)and for whom there is no clinical contraindication to fasting. Patients were randomly
 assigned to two time points for taking levothyroxine:

 A. 30 minutes before the Iftar meal B. 30 minutes before Suhour The primary outcome was the
 change in thyroid stimulating hormone (TSH) before and after Ramadan. The null hypothesis is
 that there is no difference in TSH between the two groups.

 The findings from the study will help in the clinical care of patients with hypothyroidism in
 Ramadan. Hypothyroidism is common worldwide and many Muslims will require the appropriate
 advice regarding management of hypothyroidism in Ramadan.
Inclusion Criteria:

 -  Patients with Primary hypothyroidism who had stable TSH over the last 6 months prior
 to the study period

 -  Age between 18-70 years old

 -  Patients who planned to fast during Ramadan.

 Exclusion Criteria:

 -  Patients with any end organ damage

 -  Pregnant ladies

 -  Patients with thyroid cancer

 -  Patients not adhering to medications

 -  Patients who had a clinical contraindication to observe fasting.