Efficacy and Safety of Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) in Previously Treated Participants With Select Solid Tumors (MK-7902-005/E7080-G000-224/LEAP-005)
Efficacy and Safety of Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) in Previously Treated Participants With Select Solid Tumors (MK-7902-005/E7080-G000-224/LEAP-005)
The purpose of this study is to determine the safety and efficacy of combination therapy with
 pembrolizumab (MK-3475) and lenvatinib (E7080/MK-7902) in participants with triple negative
 breast cancer (TNBC), ovarian cancer, gastric cancer, colorectal cancer (CRC), glioblastoma
 (GBM), biliary tract cancers (BTC), or pancreatic cancer. All participants will be enrolled
 into initial tumor-specific cohorts (except those with pancreatic cancer) before the cohorts
 will be expanded, if adequate efficacy is determined.
Inclusion Criteria:

 -  Has a histologically or cytologically-documented, advanced (metastatic and/or
 unresectable) solid tumor that is incurable and for which prior standard systemic
 therapy has failed in one of the following cohorts: TNBC, Ovarian Cancer, Gastric
 Cancer, Colorectal Cancer, GBM, BTC (intrahepatic, extrahepatic cholangiocarcinoma and
 gall bladder cancer; excludes Ampulla of Vater), Pancreatic Cancer

 -  Must have progressed on or since the last treatment

 -  Has measurable disease per RECIST 1.1 (RANO for the GBM cohort) as assessed by the
 local site investigator/radiology and confirmed by BICR

 -  Has provided a PD-L1 evaluable archival tumor tissue sample or newly obtained core or
 excisional biopsy of a tumor lesion not previously irradiated

 -  Male participants agree to use approved contraception during the treatment period for
 at least 7 days after the last dose of lenvatinib, or refrain from heterosexual
 intercourse during this period

 -  Female participants are not pregnant or breastfeeding, and are not a woman of
 childbearing potential (WOCBP), OR are a WOCBP that agrees to use contraception during
 the treatment period (or 14 days prior to the initiation of study treatment for oral
 contraception) and for at least 120 days post pembrolizumab, or 30 days post
 lenvatinib, whichever occurs last

 -  Has an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1 within 3
 days of study treatment initiation

 -  Has adequate organ function

 For Triple Negative Breast Cancer Participants:

 -  Has received one or 2 prior lines of therapy

 -  Has Lactate Dehydrogenase (LDH) <2.0 x Upper Limit of Normal (ULN)

 -  Has locally determined results for estrogen receptor, progesterone receptor, and human
 epidermal growth factor receptor 2 tumor analyses

 For Ovarian Cancer Participants:

 - Has received 3 prior lines of therapy. Note: The initial 30 participants in this cohort
 included participants with primary ovarian cancer. The expanded cohort will include
 participants with primary ovarian cancer, fallopian tube, and peritoneal ovarian cancer.

 For Gastric Cancer Participants:

 - Has received 2 prior lines of therapy. Note: Gastric cancer will include participants
 with both gastric and gastroesophageal junction (GEJ) adenocarcinoma. Participants with
 squamous cell carcinoma histology are not eligible

 For Colorectal Cancer Participants:

 - Has received 2 prior lines of therapy

 For GBM Participants:

 -  Has failed initial systemic therapy for newly diagnosed GBM

 -  Have the following time periods elapsed before the projected start of scheduled study
 treatment: 1) at least 3 weeks from prior surgical resection, 2) at least 1 week from
 stereotactic biopsy, 3) at least 6 months from completion of prior radiotherapy, 4) at
 least 4 weeks (or 5 half-lives, whichever is shorter) from any investigational agent,
 5) at least 4 weeks from cytotoxic therapy, 6) at least 6 weeks from antibodies, 7) at
 least 4 weeks (or 5 half-lives, whichever is shorter) from other antitumor therapies
 and 1 week for cancer vaccines

 -  Be neurologically stable (e.g. without a progression of neurologic symptoms or
 requiring escalating doses of systemic steroid therapy within last 2 weeks) and
 clinically stable

 -  Has histologically confirmed World Health Organization (WHO) Grade IV GBM

 -  Has locally determined result for O^6-methylguanine-DNA methyltransferase (MGMT)
 analysis

 For Biliary Tract Cancer Participants:

 -  Has received 1 prior line of therapy

 -  Child-Pugh Score, Class A: well-compensated disease. Child-Pugh Score of 5-6

 For Pancreatic Cancer Participants:

 -  Has pathologically (histologically or cytologically) confirmed pancreatic ductal
 adenocarcinoma that is metastatic at enrollment

 -  Has received one or 2 prior lines of therapy

 -  Has received prior therapy with at least 1 (platinum-containing regimen or
 gemcitabine-containing regimen) but no more than 2 prior systemic therapies for
 unresectable or metastatic pancreatic cancer

 Exclusion Criteria:

 -  Has presence of gastrointestinal condition including malabsorption that might affect
 the absorption of lenvatinib

 -  Has present or progressive accumulation of pleural, ascitic, or pericardial fluid
 requiring drainage or diuretic drugs within 2 weeks prior to enrollment (applies to
 all cohorts except the ovarian cancer cohort)

 -  Has radiographic evidence of major blood vessel invasion/infiltration. Participants
 with portal vein invasion (Vp4), inferior vena cava, or cardiac involvement based on
 imaging in the BTC cohort are excluded

 -  Has clinical significant hemoptysis or tumor bleeding within 2 weeks prior to the
 first dose of study treatment

 -  Has significant cardiovascular impairment within 12 months of the first dose of study
 treatment: such as history of congestive heart failure greater than New York Heart
 Association (NYHA) Class II, unstable angina, myocardial infarction or cerebrovascular
 accident (CVA), or cardiac arrhythmia associated with hemodynamic instability

 -  Has a history of arterial thromboembolism within 12 months of start of study treatment

 -  Has a known additional malignancy that is progressing or has required active treatment
 within the past 3 years.

 -  Serious nonhealing wound, ulcer or bone fracture

 -  Has had major surgery within 3 weeks prior to first dose of study interventions

 -  Has biologic response modifiers (e.g. granulocyte colony-stimulating factor) within 4
 weeks before study entry

 -  Has preexisting ≥Grade 3 gastrointestinal (GI) or non-gastrointestinal fistula

 -  Has received prior therapy with lenvatinib, an anti-PD-1, anti-PD-L1, or anti PD-L2
 agent or with an agent directed to another stimulatory or co-inhibitory T-cell
 receptor (e.g. cytotoxic T-lymphocyte-associated protein 4 [CTLA-4], Tumor necrosis
 factor receptor superfamily, member 4 [OX 40], tumor necrosis factor receptor
 superfamily member 9 [CD137])

 -  Has received prior systemic anti-cancer therapy including investigational agents
 within 4 weeks prior to study treatment start

 -  If participant received major surgery, they must have recovered adequately from the
 toxicity and/or complications from the intervention prior to starting study treatment

 -  Has received prior radiotherapy within 2 weeks of start of study treatment.
 Participants must have recovered from all radiation-related toxicities, not require
 corticosteroids, and not have had radiation pneumonitis. A 1-week washout is permitted
 for palliative radiation (≤2 weeks of radiotherapy) to non-central nervous system
 (CNS) disease

 -  Has received a live vaccine within 30 days prior to the first dose of study treatment

 -  Has known intolerance to lenvatinib (and/or any of the excipients)

 -  Is currently participating in or has participated in a study of an investigational
 agent or has used an investigational device within 4 weeks prior to the first dose of
 study treatment

 -  Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy
 (in dosing exceeding 10 mg daily of prednisone equivalent) or any other form of
 immunosuppressive therapy within 7 days prior the first dose of study treatment

 -  Has known active CNS metastases and/or carcinomatous meningitis

 -  Has tumors involving the brain stem

 -  Has severe hypersensitivity (≥Grade 3) to pembrolizumab and/or any of its excipients

 -  Has an active autoimmune disease that has required systemic treatment in past 2 years

 -  Has a history of (non-infectious) pneumonitis that required steroids or has current
 pneumonitis

 -  Has an active infection requiring systemic therapy

 -  Has a known history of human immunodeficiency virus (HIV) infection

 -  Has a known history of hepatitis B or known active hepatitis C virus infection

 -  Has a known history of active tuberculosis (TB; Bacillus tuberculosis)

 -  Is pregnant or breastfeeding or expecting to conceive or father children within the
 projected duration of the study, starting with the screening visit through 120 days
 after the last dose of study treatment

 -  Has had an allogenic tissue/solid organ transplant (large organ transplants, stem-cell
 transplant requiring chronic immunosuppressant therapy necessary to prevent graft
 rejection)

 For GBM Participants:

 -  Has carcinomatous meningitis

 -  Has recurrent tumor greater than 6 cm in maximum diameter

 -  Has tumor primarily localized to the brainstem or spinal cord

 -  Has presence of multifocal tumor, diffuse leptomeningeal or extracranial disease

 -  Has evidence of intratumoral or peritumoral hemorrhage on baseline magnetic resonance
 imaging (MRI) scan other than those that are grade ≤ 1 and either post-operative or
 stable on at least 2 consecutive MRI scans

 -  Has received Optune® TTFields within 2 weeks of study intervention