Laparoscopic Appendectomy for Uncomplicated Appendicitis: Does Antimicrobial Prophylaxis Really Matter?
Laparoscopic Appendectomy for Uncomplicated Appendicitis: Does Antimicrobial Prophylaxis Really Matter?
To compare surgical site infection (SSI) rate in patients undergoing laparoscopic
 appendectomy for acute uncomplicated appendicitis and treated with single dose regime of
 antibiotics versus group of patients undergoing laparoscopic appendectomy without antibiotics
 treatment. Patient will be given either single dose of perioperative antibiotics or no
 antibiotics before surgery.
Laparoscopic appendectomies are performed by one of the 6 institutional attending surgeons.
 US and/or abdominal CT scans are obtained as clinically necessary to make the diagnosis of
 appendicitis. All of the appendectomies are initiated laparoscopically. Postoperative orders
 are controlled via a standard electronic order set for all operations.

 Patients found to have acute uncomplicated appendicitis at appendectomy will be randomized to
 either single dose of perioperative antibiotics /On the second post-operative day the patient
 who has no fever and tolerating a regular diet, will be discharged home without oral
 antibiotics. On the post-operative, day seven after surgery all patients will be examined in
 the outpatient clinic on the presence of surgical site infection. then will be followed for a
 30 days after surgery .
Inclusion Criteria:

 -  Established diagnosis of acute appendicitis based on clinical examination, US and/or
 computed tomographic (CT) scan, and acute uncomplicated appendicitis at laparoscopic
 appendectomy.

 Exclusion Criteria:

 -  Patients with a documented allergy to any of the medications in the trial.

 -  Those with an abscess identified by computed tomographic (CT) scan before surgery are
 not included in the study