Study of Low Bone Mass in Premenopausal or Perimenopausal Women
Study of Low Bone Mass in Premenopausal or Perimenopausal Women
OBJECTIVES:

 I. Determine the possible causes of bone loss in premenopausal or perimenopausal women.
PROTOCOL OUTLINE: Patients undergo physical examination and complete history with emphasis on
 risk factors for osteoporosis and screening for occult secondary causes of osteoporosis
 through blood serum and 24 hour urine collection.

 Patients with more than 6 months since prior bone mineral density measurements or who did not
 receive measurements at participating center, undergo dual energy x-ray absorptiometry over
 30 minutes for bone mineral density measurements.
PROTOCOL ENTRY CRITERIA:

 --Disease Characteristics--

 -  Low bone mass (T score less than -2.0) with no secondary cause on routine exam

 -  Premenopausal

 OR

 -  Perimenopausal

 --Prior/Concurrent Therapy--

 -  Chemotherapy: No prior or concurrent chemotherapeutic agents

 -  Endocrine therapy: No prior or concurrent glucocorticoids or suppressive doses of
 thyroid hormone

 -  Other: No prior or concurrent anticonvulsants

 --Patient Characteristics--

 -  Hematopoietic: No multiple myeloma

 -  Other: No hyperparathyroidism No thyrotoxicosis No anorexia nervosa No Paget's disease
 of bone No rheumatoid arthritis No Cushing's syndrome No malabsorption syndrome No
 type I diabetes mellitus