Tumor Tissue, Blood Samples, and Family History in Predicting Tumor Development and Response to Treatment in Young Patients With Low-Grade Glioma
Tumor Tissue, Blood Samples, and Family History in Predicting Tumor Development and Response to Treatment in Young Patients With Low-Grade Glioma
RATIONALE: Studying samples of tumor tissue and blood in the laboratory may help doctors
 learn more about changes that occur in DNA and identify biomarkers related to cancer. It may
 also help doctors understand why low-grade gliomas develop in young patients and predict how
 they will respond to treatment.

 PURPOSE: This clinical trial is studying tumor tissue, blood samples, and family history in
 predicting tumor development and response to treatment in young patients with low-grade
 glioma.
OBJECTIVES:

 -  To develop a better understanding of why low-grade glioma tumors develop in children and
 adolescents.

 -  To study genetic profiles that may predict response to treatment and provide clues to
 how these tumors developed initially using tumor and blood samples from these patients.

 OUTLINE: This is a multicenter study.

 -  Retrospective data collection (for participants recruited from study SIOP-LGG1): During
 a follow-up appointment for study SIOP-LGG1, both biological parents* are asked to
 complete a questionnaire about their family's cancer history. They may complete the
 questionnaire either in the clinic or in their home. Participants may complete and
 return the questionnaires at any time throughout the study.

 -  Prospective data collection (for participants recruited from study SIOP-LGG-2004): Both
 biological parents* are asked to complete a family history questionnaire and provide
 information about their family's cancer history. Participants may complete and return
 the questionnaires at any time throughout the study.

 NOTE: *In circumstances where either or both biological parents are unable to complete the
 questionnaire, it may be completed by the patient diagnosed with low grade glioma (if they
 are over 16 years old) or adoptive parents or guardians, if they feel they have the knowledge
 to complete the questionnaire.

 Tumor tissue and blood samples collected on SIOP-LGG1 or SIOP-LGG-2004 are analyzed for
 genetic profiles predictive of response to treatment and for different patterns of tumor
 development, natural tumor behavior, and tumor sensitivity to cancer therapies. Collected
 family data are anonymised and linked to the biological sample collected. Samples are then
 stored for future molecular genetic studies.
DISEASE CHARACTERISTICS:

 -  Biological parents of a child or adolescent patient diagnosed with low grade glioma
 (LGG)

 -  LGG patients participating in 1 of the following clinical trials:

 -  On active follow up for study SIOP-LGG1 at a Children's Cancer and Leukemia
 Group center

 -  On study SIOP-LGG-2004

 -  Adoptive parents or guardians allowed if they feel they have the knowledge to
 complete the study questionnaire, provided either or both biological parents are
 unable to complete the questionnaire

 PATIENT CHARACTERISTICS:

 -  Not specified

 PRIOR CONCURRENT THERAPY:

 -  Not specified