Fecal Microbiota Transplantation for Pancreatitis With Infectious Complications(FMTPIC)
Fecal Microbiota Transplantation for Pancreatitis With Infectious Complications(FMTPIC)
Infectious complications are responsible for most of deaths in acute pancreatitis.Intestinal
 barrier dysfunction and increased intestinal permeability was associated with bacterial
 translocation which is believed to prompted these infections.The purpose of this clinical
 trail is to observe the potential capability of FMT in reduce the bacterial translocation and
 alleviate infectious complications by the reconstruction of a gut functional state.
Investigators aims to restore the intestinal bacteria homeostasis through FMT by retention
 enema with fresh bacteria,thus minimizing bacterial translocation and alleviating infectious
 complications. The investigators will further examine the effect of FMT on the incidence of
 infectious complications，duration of clinical course and mortality.
Inclusion Criteria:

 1. Diagnosis of severe acute pancreatitis from the First Affiliated Hospital of Nanchang
 University according to the Classification of acute pancreatitis-2012: revision of the
 Atlanta classification and definitions by international consensus

 2. Onset of pancreatitis more than 2 weeks

 3. Intestinal bacterium screening tips gut dysbacteriosis

 4. Patients with symptoms of infection, such as fever, abdominal pain or blood culture
 and pancreatic necrosis drainage culture positive patients.

 Exclusion Criteria:

 1. SAP complicated by Gastrointestinal bleeding or Intestinal fistula

 2. Pregnancy and lactation women

 3. Not signed the informed consent