Combined Modality Exercise and Appetite in Breast Cancer Survivors
Combined Modality Exercise and Appetite in Breast Cancer Survivors
The overall aim of this research is to assess the feasibility of a 12-week combined aerobic
 exercise (AEx) and resistance exercise (REx) intervention and elucidate the impact of AEx/REx
 on several physiological and behavioral components of energy balance among breast cancer
 survivors (BCS).
Inclusion Criteria:

 -  Female sex

 -  Age: 18 - 45 years

 -  Body mass index [BMI]: 25 - 35 kg/m2

 -  Pre-menopausal before cancer diagnosis and treatment

 -  <1 hour/week of planned physical activity by self-report in the previous 12 months

 -  Diagnosis of primary stage I - III estrogen receptor/progesterone receptor-positive
 (ER/PR+) breast cancer, according to institutional standards.

 -  All chemotherapy, radiation, and surgery completed at least two weeks (14 days), but
 less than 6 months prior to registration

 Exclusion Criteria:

 -  Self-reported diabetes mellitus, untreated/uncontrolled thyroid disease, history of
 cardiovascular disease or symptoms suggestive of cardiovascular disease (chest pain,
 shortness of breath at rest or with mild exertion, syncope), cancer diagnosis in the
 last 5 years before breast cancer (any site, excluding skin cancer), or any other
 medical condition affecting weight or energy metabolism.

 -  Uncontrolled hypertension defined as: systolic blood pressure >160 mmHg or diastolic
 blood pressure >100mmHg, as measured during the screening visit. Participants who are
 deemed ineligible based upon uncontrolled hypertension criteria will be referred to
 their primary care physicians for treatment. If this condition becomes controlled they
 will be allowed to be re-evaluated for inclusion in the current trial.

 -  Unable to exercise due to cardiac, pulmonary, neurological, orthopedic reasons.

 -  Currently smoking and/or nicotine use.

 -  Treatment with medications known to significantly affect appetite, weight, energy
 intake or expenditure in the last 3 months (e.g. appetite suppressants, lithium,
 stimulants, anti-psychotics, tricyclic antidepressants).

 -  Corticosteroid use within the last two weeks

 -  History of surgical procedure for weight loss at any time (e.g. gastroplasty, gastric
 bypass, gastrectomy or partial gastrectomy, adjustable banding, gastric sleeve);
 history of extensive bowel resection for other reasons

 -  Currently pregnant, lactating or less than 6 months post-partum.

 -  Score of ≥ 2 on the CAGE (cut-annoyed-guilty-eye opener) questionnaire adapted to
 include drug use55

 -  Score of > 20 on the Eating Attitude Test - 26 (EATS-26), indicative of disordered
 eating. Participants with a score >20 on the EATS-26 will be referred to their primary
 care physician for further evaluation.

 -  Significant food intolerances/allergies that cannot be accommodated by the University
 of Colorado Hospital Clinical Translational Research Center Metabolic Kitchen.

 -  Currently participating in any formal weight loss or physical activity programs or
 clinical trials for weight loss.

 -  Other medical, psychiatric, or behavioral limitations that may interfere with
 participation (as determined by study physician).

 -  Unable or unwilling to undergo study procedures