Factors Predicting Persistence of Oncogenic HPV and Cervical Dysplasia in HIV Infected Kenyan Women
Factors Predicting Persistence of Oncogenic HPV and Cervical Dysplasia in HIV Infected Kenyan Women
This study will utilize a longitudinal study design to better understand the natural history
 of oncogenic Human Papillomavirus (HPV) infections in Human Immunodeficiency Virus
 (HIV)-infected and HIV-uninfected Kenyan women, including the potentially modifiable (and
 non-modifiable) factors that are associated with progression of oncogenic HPV infection to
 clinical disease, including cervical cancer.
Inclusion Criteria:

 1. Kenyan women who present for a cervical cancer screening at AMPATH-cervical cancer
 screening clinics at MTRH or Webuye and living in or within 30 km of the respective
 clinic at the time of informed consent

 2. Between the ages of 18 -45 years old at the time of informed consent

 3. Ability to provide written informed consent and HIPAA authorization

 4. Must have a normal VIA

 5. Must be willing and able to come to the clinic for visits and return for a 4 year
 follow-up visit

 Exclusion Criteria:

 1. History of an abnormal VIA or Pap smear

 2. Diagnosis of CIN or cervical cancer

 3. Signs or symptoms of a sexually transmitted infection (STI)

 4. Women who are currently pregnant

 5. Inability to understand and provide written informed consent due to a mental or
 physical disability, or a medical illness that has rendered the patient unable to
 understand consent or attend quarterly visits