Database Of Clinical Data For Individuals With Variants In The IRF2BPL Gene
Database Of Clinical Data For Individuals With Variants In The IRF2BPL Gene
This protocol serves as a data collection tool for individuals with variants (missense,
 nonsense, frameshifts) in the IRF2BPL gene (MIM 611720), which causes Neurodevelopmental
 Regression, Seizures, Autism and Developmental Delay (NEDAMSS, MIM 618088) and may be
 involved in other neurodevelopmental presentations. This information will be analyzed to
 develop a better understanding of the findings and progression of symptoms in individuals
 with variants in the IRF2BPL gene.
Neurodevelopmental Regression, Abnormal Movements, Loss of Speech, and Seizures (NEDAMSS) is
 caused by changes in the IRF2BPL gene. Variants in the gene can also lead to other
 neurodevelopmental presentations. Due to the limited number of cases that have been described
 to date, clinicians may have a limited understanding of what types of symptoms can develop in
 affected individuals and at what age. The purpose of the study is to gather clinical
 information about progression, treatments and outcomes for patients with variants in IRF2BPL.
 The investigators will collect information about medical history, growth, development,
 treatments and the results of previous genetic tests. In some cases, the investigators may
 also collect tissue samples. This is a non-interventional study that will expand the current
 understanding of the range of health concerns that can be seen in individuals with changes in
 the IRF2BPL gene by collecting medical information and samples from a larger group of
 affected individuals.
Inclusion Criteria:

 -  Living or deceased individuals with variants in the IRF2BPL gene

 Exclusion Criteria:

 -  None