Boosting the Secretion of GLP-2 and GLP-1 Intestinal Hormones by Nutrients
Boosting the Secretion of GLP-2 and GLP-1 Intestinal Hormones by Nutrients
This pilot study is aimed at assessing the acute effect of several combinations of lipids
 differing in their fatty acid composition on glucagon-like-peptide (GLP)-2 and GLP-1
 secretion in healthy subjects.
In this study, the investigators aim to investigate the effect of various lipid types on
 GLP-2 and GLP-1 secretion. This will allow to determine the importance of lipids in
 nutritional solutions. Moreover, this will allow us to assess whether existing clinical
 formulas can be improved in order to stimulate GLP-2 and accelerate intestinal recovery.
Inclusion Criteria:

 -  BMI : 19 - 24.9 kg.m-2

 -  Normal fasting glycemia

 -  Having obtained his informed consent.

 Exclusion Criteria:

 -  Gastro-intestinal disease (ulcer), pancreatic disease, hepatic disease, metabolic
 diseases / disorders (diabetes, dyslipidemia), renal disease, cardiovascular disease
 (arterial hypertension), as determined by the medical screening visit and a blood
 analysis.

 -  Have had a gastrointestinal surgery (with the exception of appendices resection).

 -  Malabsorption disorders

 -  Lactose intolerance

 -  Significant weight loss during the past three months (more than 5% of initial weight)

 -  Have a regular consumption of medication

 -  Regular supplements (vitamins and minerals) intake during the previous month

 -  Have an alcohol intake: > 2 units a day

 -  Smoker (more than 2 cigarettes a day)

 -  Illicit substances intake, as stated on the medical screening questionnaire

 -  Allergy to any food or medication

 -  Anaemia defined by a number of erythrocytes or hemoglobin Hb or hematocrit Ht which
 are inferior to laboratory normal ranges

 -  Having given blood in the past three months or willing to give blood in the 3 months
 following the completion of the study

 -  Intense physical activity > 3 hours per week

 -  Currently participating or having participated in another clinical trial during the
 past month.

 -  Volunteer who cannot be expected to comply with the protocol, including consuming
 rapidly the study products, chronic medication intake