Dinaciclib, Bortezomib, and Dexamethasone in Treating Patients With Relapsed Multiple Myeloma
Dinaciclib, Bortezomib, and Dexamethasone in Treating Patients With Relapsed Multiple Myeloma
This phase I trial studies the side effects and best dose of dinaciclib and bortezomib when
 given together with dexamethasone in treating patients with multiple myeloma that has
 returned after a period of improvement. Dinaciclib and bortezomib may stop the growth of
 cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in
 chemotherapy, such as dexamethasone, work in different ways to stop the growth of cancer
 cells, either by killing the cells, by stopping them from dividing, or by stopping them from
 spreading. Giving dinaciclib and bortezomib together with dexamethasone may kill more cancer
 cells.
PRIMARY OBJECTIVES:

 I. To determine the maximally tolerated doses of dinaciclib and bortezomib, when used in
 combination, in two different schedules, for treatment of relapsed multiple myeloma.

 SECONDARY OBJECTIVES:

 I. To determine the toxicities associated with dinaciclib and bortezomib, when used in
 combination, for treatment of relapsed multiple myeloma.

 II. To determine the overall response rate associated with dinaciclib and bortezomib, when
 used in combination, for treatment of relapsed multiple myeloma.

 III. To explore the differences in toxicity associated with two different schedules of
 dinaciclib and bortezomib used in combination.

 TERTIARY OBJECTIVES:

 I. To examine if expression levels of target cyclin dependent kinase (CDK): CDK 2,5,7 and 9
 levels in cluster of differentiation (CD)138-purified tumor cells, will be correlated with
 response (clinical and molecular) to determine if high or low level target CDK expression, if
 present, influences dinaciclib efficacy.

 II. To examine if immunoglobulin (Ig)H translocation status, P53 status and presence of v-myc
 myelocytomatosis viral oncogene homolog (avian) (Myc) amplification or rearrangement,
 determined on patient bone marrow before treatment, using a pre validated fluorescence in
 situ hybridization (FISH) panel to identify common myeloma translocations, will be correlated
 with molecular and/or clinical markers of drug activity, and to assess if specific genetic
 subgroups of myeloma tumors are responsive or resistant.

 III. To determine the gene expression profiles of myeloma cells before and after treatment to
 understand the role of tumor gene dysregulation and/or dinaciclib induced effects on
 transcription.

 OUTLINE: This is a dose-escalation study of dinaciclib and bortezomib. Patients are assigned
 to 1 of 2 treatment schedules.

 SCHEDULE I: Patients receive dinaciclib intravenously (IV) over 2 hours and bortezomib
 subcutaneously (SC) or IV (if patients do not tolerate SC injection) on days 1, 8, and 15 and
 dexamethasone orally (PO) once daily (QD) on days 1, 2, 8, 9, 15, and 16. Courses repeat
 every 28 days in the absence of disease progression or unacceptable toxicity.

 SCHEDULE II: Patients receive dinaciclib IV over 2 hours on day 1; bortezomib SC on days 1
 and 8; and dexamethasone PO QD on days 1, 2, 8, and 9. Courses repeat every 21 days in the
 absence of disease progression or unacceptable toxicity.

 After completion of study treatment, patients are followed up at 30 days and 3 months.
Inclusion Criteria:

 -  Serum creatinine =< 2.5 mg/dL

 -  Absolute neutrophil count >= 1000/uL

 -  Untransfused platelet count >= 75000/uL

 -  Hemoglobin >= 8 g/dL

 -  Total bilirubin =< 1.5 times institutional upper limit of normal (ULN)

 -  Patients with relapsed multiple myeloma who have already received one or more standard
 treatment regimens

 -  Measurable disease of multiple myeloma as defined by at least ONE of the following:

 -  Serum monoclonal protein >= 1 g/dL

 -  >= 200 mg of monoclonal protein in the urine on 24 hour electrophoresis

 -  Serum immunoglobulin free light chain >= 10 mg/dL and abnormal serum
 immunoglobulin kappa to lambda free light chain ratio

 -  Monoclonal bone marrow plasmacytosis >= 30% (evaluable disease)

 -  Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0, 1 or 2

 -  Adequate residual organ function per treating physician discretion; Note: there is no
 limit with regard to the number of prior therapies

 -  Provide informed written consent

 -  Negative pregnancy test done =< 7 days prior to registration, for women of
 childbearing potential only

 -  Willing to provide samples for correlative research purposes

 -  Willing to return to consenting institution for follow-up during the study

 -  Recovered (i.e., =< grade 1 toxicity) from the reversible effects of prior
 antineoplastic therapy

 Exclusion Criteria:

 -  Any of the following recent therapies:

 -  Alkylators (e.g. melphalan, cyclophosphamide) =< 14 days prior to registration

 -  Anthracyclines =< 14 days prior to registration

 -  High dose corticosteroids, immune modulatory drugs (thalidomide or lenalidomide),
 or proteosome inhibitors (bortezomib) =< 7 days prior to registration

 -  Concomitant high dose corticosteroids (concurrent use of corticosteroids); EXCEPTION:
 patients may be on chronic steroids (maximum dose 20 mg/day prednisone equivalent) if
 they are being given for disorders other than amyloid, i.e., adrenal insufficiency,
 rheumatoid arthritis, etc.

 -  Other active malignancy =< 2 years prior to registration; EXCEPTIONS: non-melanotic
 skin cancer or carcinoma in-situ of the cervix; NOTE: if there is a history of prior
 malignancy, they must not be receiving other specific treatment for their cancer

 -  Any of the following:

 -  Pregnant women or women of reproductive ability who are unwilling to use 2
 effective methods of contraception from the time of signing the informed consent
 form through 30 days after the last dose of study drug

 -  Nursing women

 -  Men who are unwilling to use a condom (even if they have undergone a prior
 vasectomy) while having intercourse with any woman, while taking the drug and for
 30 days after stopping treatment

 -  Other co-morbidity which would interfere with patient's ability to participate in
 trial, e.g. uncontrolled infection, uncompensated heart or lung disease

 -  Other concurrent chemotherapy, radiotherapy, or any ancillary therapy considered
 investigational; NOTE: bisphosphonates are considered to be supportive care rather
 than therapy, and are thus allowed while on protocol treatment

 -  Peripheral neuropathy >= grade 2 on clinical examination during the screening period

 -  Major surgery =< 14 days prior to registration

 -  Currently taking strong or moderate inhibitors/inducers of cytochrome P450, family 3,
 subfamily A, polypeptide 4 (CYP3A4); Note: dinaciclib is a CYP3A4 substrate; patients
 should not take grapefruit/grapefruit juice or St. John's wort; use of strong or
 moderate CYP3A4 inhibitors is prohibited from < 7 days prior to registration; use of
 CYP3A4 inducers is prohibited from =< 7 days prior to registration

 -  Any of the following conditions:

 -  Myocardial infarction =< 6 months prior to registration or has New York Heart
 Association (NYHA) class III or IV heart failure

 -  Uncontrolled angina

 -  Severe uncontrolled ventricular arrhythmias

 -  Electrocardiographic evidence of acute ischemia

 -  Active conduction system abnormalities; NOTE: prior to study entry, any
 electrocardiogram (ECG) abnormality at screening must be documented by the
 investigator as not medically relevant

 -  Known hypersensitivity to bortezomib, boron, or mannitol

 -  Serious medical or psychiatric illness likely to interfere with participation in this
 clinical study per the judgment of the treating physician