Non-steroidal Anti-inflammatory Drugs Alone or With a Triptan and Reports of Transition From Episodic to Chronic Migraine
Non-steroidal Anti-inflammatory Drugs Alone or With a Triptan and Reports of Transition From Episodic to Chronic Migraine
Chronic Migraine (CM), or 15 or more migraine headaches per month, is common in tertiary
 headache care and is associated with a number of deleterious outcomes, especially higher
 disability and poorer quality of life, relative to those with Episodic Migraine (EM) defined
 as 14 or fewer migraine headaches per month. Limited work has begun to examine factors that
 increase or decrease the risk of developing CM. One factor that appears especially relevant
 is symptomatic medication use. The current study builds upon and expands previous work
 considering the influence non-steroidal anti-inflammatory drug (NSAID) and/or triptan use has
 on the likelihood of developing CM.

 This study is a retrospective observational cohort study of data collected via mail survey
 and collated in the American Migraine Prevalence and Prevention (AMPP) database.

 Survey results from the AMPP study will be analyzed retrospectively. The AMPP is a
 longitudinal, population-based, mailed-questionnaire survey. In 2004, 120,000 United States
 (US) households were screened and 24,000 individuals who reported severe headaches were
 identified and additional questionnaires have been administered annually. This analysis uses
 data from respondents who meet second edition of the International Headache Classification-2
 (IHCD-2) criteria for EM in 2005 with follow up results in 2006, 2007, 2008, and 2009. EM is
 defined as 1 to 14 headaches per month and CM is defined as 15 or more headaches per month.
Inclusion Criteria:

 -  Respondents age 18 or older at the time of survey completion

 -  Respondents completed the questionnaires in 2004 and at least one other year (2005,
 2006, 2007, 2008, 2009)

 -  Based on the respondents answers to the 2004 survey, their symptoms meet the criteria
 for EM which is characterized by headaches meeting International Classification of
 Headache Disorders - 2 (ICHD-2) criteria for migraine 1-14 days a month

 Exclusion Criteria:

 -  Responses to questions suggest that the respondent's diagnosis is not migraine or CM