Detection of Aggressive Breast Tumors Using Tc-99m-NC100692
Detection of Aggressive Breast Tumors Using Tc-99m-NC100692
The purpose of this study is to compare two types of radioactive drugs to see if they provide
 the same or different information about any disease that may be present in the participants
 breast.
Inclusion Criteria:

 -  Have a lesion on mammogram, ultrasound or breast MRI that measured < 15 mm in
 diameter, is considered suggestive or highly suggestive of malignancy according to the
 Breast Imaging Reporting and Data System Atlas criteria (BIRADS 4b, 4c or 5), and is
 scheduled for biopsy (needle biopsy and/or surgical biopsy).

 OR

 -  Have a lesion on mammogram, ultrasound or breast MRI that measured > 15 mm in
 diameter, is known to be malignant and is scheduled for surgery.

 -  Patient age > 18 years of age.

 -  Have a negative pregnancy test on the first day of the study, or must be
 postmenopausal or surgically sterilized.

 Exclusion Criteria:

 -  Patients will be excluded if they have a small lesion (< 15 mm) and have undergone
 prior needle biopsy of the lesion (such biopsy may effectively remove all or part of
 the lesion and angiogenesis associated with wound healing might confound imaging
 results with 99mTc-NC100692).

 -  Patient's pregnancy is not negative on the first day of the study, or the patient is
 unable to complete the pregnancy test

 -  Patient is unable to sit on a chair for 40 minutes