Effect of CGF on Frequency of Alveolar Osteitis Following Partially Erupted Mandibular Third Molar Surgery
Effect of CGF on Frequency of Alveolar Osteitis Following Partially Erupted Mandibular Third Molar Surgery
The aim of this prospective study was to assess the effectiveness of concentrated growth
 factors (CGFs) in preventing the development of alveolar osteitis (AO) after the extraction
 of partially-erupted mandibular third molars.

 This study was designed as a randomized controlled clinical trial. In each case, one socket
 received CGFs and the other served as a control. The predictor variable was the CGFs
 application and the sides were categorized as 'CGFs' and 'non-CGFs'. The outcome variable was
 the development of AO during the first postoperative week. Also, demographic variable
 included age and gender was noted.
The investigators designed and implemented a randomized single-blind clinical
 trial.Randomization was performed by simple coin toss to select the side of CGFs fibrin gel
 placement before the commencement of third molar surgery. In this way, the sides in each
 patient were randomly divided into 2 study groups:

 Group I (test) - with CGFs placed in the extraction socket Group II (control) - without CGFs
 placement All operations were performed under local anesthesia by the same surgeon. An
 envelope flap was raised to provide access. Bone removal was done with the help of stainless
 steel burs. Constant irrigation with saline was used while removing bone to prevent thermal
 necrosis. Third molar was luxated with the help of straight elevator and then extracted with
 the help of third molar forceps. After extraction, any remains of the dental follicle were
 removed and the extraction sockets were irrigated with 60 mL of sterile saline. To prevent
 the flap laceration, bone contouring was also performed under sterile saline irrigation. CGFs
 fibrin gel was then randomly placed into one socket and the opposite side was considered as
 the control. Finally, wound closure was completed with silk suture.

 The primary outcome variable was AO, classified as present or absent.It is characterized by
 postoperative pain in and around the extraction side, which increases in severity within
 first week after the extraction, accompanied by a partially or totally disintegrated blood
 clot within the alveolar socket, with or without halitosis. Other defining symptoms that have
 been reported in the literature are radiating pain towards the temporal region and ear,
 inflamed gingival margin, ipsilateral regional lymphadenopathy and, less commonly, low-grade
 fever.
Inclusion Criteria:

 -  Patients Age ≥ 18 years of age

 -  Willing and able to provide informed consent

 -  Ability to cooperate with the requirements of the study protocol

 -  Healthy patients without medical diseases or a history of bleeding problems

 -  Patients with the need of extraction of third molars

 -  The third molars had to be symmetrical, partially-erupted and in the Class I, Level B
 according to Pell & Gregory classification and in the vertical angulations according
 to Winter's classification.

 Exclusion Criteria:

 -  Patients who have pre-existing abscess or cellulitis, acute pericoronitis, or
 pre-existing conditions such as an odontogenic cyst or tumour associated with their
 third molars

 -  Patients who were pregnant and breastfeeding

 -  Patients with drug usage such as bisphosphonate, steroids and antidepressants

 -  Patients who had a smoking habit