Anti-pseudomonas IgY to Prevent Infections in Cystic Fibrosis
Anti-pseudomonas IgY to Prevent Infections in Cystic Fibrosis
Hypothesis: Daily gargling with specific avian antibodies against Pseudomonas aeruginosa will
 prevent infections with this bacteria in patients with Cystic fibrosis (CF).
"Anti-pseudomonas IgY" is prepared from eggs of hens that have been vaccinated with
 Pseudomonas aeruginosa. The hens farm is under veterinary control according to Swedish rules.
 The drug is prepared with a water dilution method according to GMP standards (approved by
 Swedish MPA). Patients with CF who are intermittently but not chronically infected with P.
 aeruginosa get a short course of antibiotics to eradicate the bacteria. Thereafter they start
 to gargle with a solution of "anti-pseudomonas IgY" every night to prevent a new infection.
 Preliminary results have shown that it takes a significantly longer time to get a new
 infection and that the patients get fewer infections than control patients. In addition,
 results tentatively indicate that: patients have not got any new opportunistic bacteria or
 fungi (B. Cepacia, S. Maltophilia, A. Xylosoxidans, atypical Mycobacteria, Aspergillus
 Fumigatus); that use of antibiotics is greatly diminished; that the lung functions and
 nutritional conditions are maintained.
Inclusion Criteria:

 -  Clinical diagnosis of cystic fibrosis

 -  Colonized with Pseudomonas aeruginosa

 -  informed consent

 Exclusion Criteria:

 -  Egg allergy