Efficacy of Purslane in Treatment of Oral Lichen Planus
Efficacy of Purslane in Treatment of Oral Lichen Planus
Oral lichen planus (OLP) is a chronic inflammatory disease whose prevalence in the general
 population is 0.5 -2.2%.Oral lesions in OLP are chronic, rarely undergo spontaneous
 remission. Patients with OLP had significantly increased risk of oral squamous cell
 carcinoma, irrespective of the clinical type of OLP and therapy. there is currently no cure
 for OLP. Previous study demonstrated a decreased antioxidant defence and increased oxidative
 damage to lipids.DNA and proteins in lichen planus. This oxidative modifications point to
 pathophysiological alterations mainly within the basal cell layers of epidermis and at the
 dermoepidermal junction. Purslane is an excellent source of vitamin A,C and E and essential
 amino acids, has been described as a power food of the future because of its high nutritive
 and antioxidant properties. The purpose of the study was to determined the efficacy of
 Purslane in the treatment of oral lichen planus.
Oral lichen planus is a chronic common inflammatory disorder affecting stratified squamous
 epithelia. The majority problem of OLP is development of oral squamous cell carcinoma ,
 irrespective of the clinical type of OLP and therapy. Previous study demonstrated a decreased
 antioxidant defence and increased oxidative damage to lipids, DNA and proteins in lichen
 planus .This oxidative modifications point to pathophysiological alterations mainly within
 the basal cell layers of epidermis and at the dermoepidermal junction. So oxidative stress
 could be effective in pathogenesis of OLP. Purslane is an excellent source of vitamin A,C and
 E and essential amino acids, has been described as a power food of the future because of its
 high nutritive and antioxidant properties. Purslane also decreased the level of TNF-α and
 IL6, that are responsible for up-regulated adhesion molecules (in OLP lymphocyte T (T cell)
 recruited and retained in sub mucosa through receptors to endothelial adhesion molecule. and
 basal keratinocytes undergo apoptosis). The purpose of the study was to determined the
 efficacy of Purslane in the treatment of oral lichen planus.
Inclusion Criteria:

 -  Biopsy confirmed symptomatic oral lichen planus: WHO histological criteria in
 combination with clinical appearance will be used for diagnosis

 -  Patients who had symptoms such as burning sensation, pain

 -  Patients not on any immunosuppressive or immunomodulatory treatment. In case they
 were,then such treatment should be stopped and a washout period of 1 month was given.

 -  Patients of both sexes between 30 to 70 year's old

 -  Patients who gave written informed consent

 -  Patients who were willing for evaluation in second week after therapy and every 1
 month up to 6 months

 Exclusion Criteria:

 -  The presence of histological signs of dysplasia

 -  Patients suffering from any localized or systemic disease

 -  Renal disease patients

 -  Pregnant patients

 -  Patients who can not continue the study for private or social reasons

 -  Patients who used lichenoid reaction including drugs