Pathophysiologic Changes in the Respiratory System After Fire Smoke Inhalation
Pathophysiologic Changes in the Respiratory System After Fire Smoke Inhalation
Fire smoke inhalation may contribute to intrabronchial inflammation, airway obstruction and
 impaired gas exchange. In this study the investigators will examine if the scope of
 inhalation injury can be assessed soon after hospital admission based on clinical markers,
 biochemical markers, Peak Expiratory Flow (PEF), spirometry and bronchoscopy. At 6 months a
 lung function test and metacholine test will be performed to examine whether patients have
 developed increased bronchial hyperreactivity (asthma) or not after the initial fire smoke
 exposure.
Fire smoke inhalation may contribute to intrabronchial inflammation, airway obstruction and
 impaired gas exchange. The scope of injury in fire smoke victims ranges from cough and minor
 airway irritation to severe respiratory failure and long term mechanical ventilation in the
 Intensive Care Unit. Some patients with high HbCO-levels are also treated with hyperbaric
 oxygen therapy.

 In this study the investigators will examine if the scope of inhalation injury can be
 assessed soon after admission based on clinical markers, biochemical markers, Peak Expiratory
 Flow (PEF), spirometry and bronchoscopy. The clinical effect of fiberoptic bronchoscopy after
 severe smoke inhalation will also be examined. At 6 months a lung function test and
 metacholine test will be performed to examine whether they have developed asthma/increased
 bronchial hyperreactivity or not after the initial fire smoke exposure. Lab staff
 (flowcytometer and cytokine analysis) are unaware of patient identity and whether the patient
 is a smoke-exposed patient or a healthy volunteer in the control group of non-exposed
 persons.
Inclusion Criteria:

 -  fire smoke exposed patient

 -  > 18 years of age

 -  admitted to hospital

 Exclusion Criteria:

 -  < 18 years of ager

 -  trauma patient

 Control group (healthy volunteers/hospital staff):

 -  > 18 years of age

 -  non-smoker

 -  no exposure to fire smoke