Intrapleural Bevacizumab Injection for Malignant Effusion in Lung Cancer
Intrapleural Bevacizumab Injection for Malignant Effusion in Lung Cancer
Malignant pleural or pericardial effusion is common in lung cancer, and intrapleural drugs
 injection is important in the treatment. Non- cytotoxic drugs include those with a sclerosing
 effect that produces pleurodesis, which is easy to cause severe chest pain despite of no
 influence on the following chemotherapy. Tumor angiogenesis is important in producing MPE.
 Bevacizumab has been administrated locally in treating optic nerve sickness successfully by
 anti-VEGF mechanism. So we hypothesize that intrapleural bevacizumab is also effective in
 treating MPE.
Inclusion Criteria:

 1. Histological or cytological diagnosis of non-small cell lung cancer.

 2. Cytological diagnosis of malignant pleural or pericardial effusion (MPE)

 3. Symptomatic MPE evaluated by researchers

 4. Unsuitable for or reject systemic therapy of tumor

 5. Continuous TKI treatment after TKI-resistance

 6. Estimated survival of more than 3 months. 7.18 years or older

 Exclusion Criteria:

 1. Current or recent (within 10 days prior to treatment) use the full amount of inhibition
 of platelet function, anticoagulants or thrombolytic therapy, which allows prophylactic
 anticoagulants

 2. Be allergic to bevacizumab

 3. Pregnant or lactating woman

 4. Pleural or pericardial infection
Inclusion Criteria:

 1. Histological or cytological diagnosis of non-small cell lung cancer.

 2. Cytological diagnosis of malignant pleural or pericardial effusion (MPE)

 3. Symptomatic MPE evaluated by researchers

 4. Unsuitable for or reject systemic therapy of tumor

 5. Estimated survival of more than 3 months. 6.18 years or older

 Exclusion Criteria:

 1. Current or recent (within 10 days prior to treatment) use the full amount of
 inhibition of platelet function, anticoagulants or thrombolytic therapy, which allows
 prophylactic anticoagulants

 2. Be allergic to bevacizumab

 3. Pregnant or lactating woman

 4. Pleural or pericardial infection