Cognitive Training in Attenuating Attention Deficits/Child Treatment for Cancer
Cognitive Training in Attenuating Attention Deficits/Child Treatment for Cancer
Primary Objectives:

 1. To evaluate the feasibility of enrolling children and adolescents with newly diagnosed
 brain tumors, leukemia, or lymphoma in a program designed to prevent the academic and
 cognitive declines that commonly result following central nervous system (CNS) disease
 and treatment.

 Hypothesis 1: Despite the rigors of disease and treatment, children and adolescents will
 be able to participate in the CTP while they are receiving treatment for cancer. The
 high participation of our patients in routine school activities during treatment
 suggests that they will have the energy and interest required to participate in
 cognitive training.

 2. To evaluate whether a Cognitive Training Program (CTP) might be helpful to patients in
 preventing attention deficits that commonly result following CNS disease and therapy.

 Hypothesis 2: Patients in the CTP arm of the study will show fewer declines in
 neurocognitive performance at the end of training and again six months later, as
 compared with the control group who will receive the usual services provided by the
 Education Program in Pediatrics.

 3. To explore the relationship between CTP treatment compliance and stability/decline in
 cognitive and academic performance in children and adolescents who are being treated for
 brain tumors, leukemia, and lymphoma.

 Hypothesis 3: Level of compliance with CTP treatment will be predictive of a patient's
 performance on neurocognitive measures.
The Cognitive Training Program (CTP) is made up of many elements. It includes procedures that
 are designed to build five types of attention skills, as well as motivational activities that
 exercise your child's attention processes. The CTP includes instructions on how to improve
 the way your child's mind approaches a task, how he/she performs different tasks, and what
 he/she does after finishing tasks. The CTP also includes the use of therapy to improve and
 maintain motivation, self-esteem, and self-confidence, as well as to help your child stay
 motivated and keep from getting distracted.

 Before your child can take part in this study, he/she will have what is called a "screening
 test of intelligence." This test will help the doctor decide if your child is eligible to
 take part in the study. In order for a child to participate in the study, he or she has to
 achieve a score > 70 on the screening test (at least within the borderline range of
 intelligence), because this level of intelligence is necessary for a child to understand the
 CPT educational materials. It is possible that after this test, your child may not be able to
 continue on this study. The screening test results will be discussed with you.

 Your child will be randomly assigned (as in the toss of a coin) to either the CTP or a
 "control" group. The control group will receive standard educational support, but will not
 receive the one-on-one cognitive training given during the study. After the study is
 completed, patients randomized to the control group will be eligible to receive the CTP
 intervention, free of charge, if the parents prefer. All participants will complete
 standardized cognitive and academic tests at three time points: at the beginning of the
 study, six months later, and then six months after that. The tests will be given by a very
 experienced research assistant who will ask your child questions and have him or her complete
 various paper and pencil tasks or puzzles. Testing at each of the three time points will take
 about 3 hours. However, the test sessions can be divided into shorter sessions, if necessary
 for the child's comfort. After each test session, you and your child will talk to a member of
 the study staff about your child's results and what they mean to your child's progress.

 Your child will be seen for a total of 20 study-therapy visits (as long as they are in the
 intervention group) over a 4 to 6 month training period. Each visit will be about two hours
 long, and will occur once a week during the training period. The study visits will be
 "one-on-one" sessions between your child and the therapist. Each study visit will be include
 two 50-minute training sessions with a 15-minute break between them. During training
 sessions, your child will participate in several activities. Each activity will only last
 about 15 minutes each. If your child gets tired during a session, the therapist will let
 him/her take a short rest break.

 The therapy program your child receives will be especially designed for him/her, building on
 his/her strengths as well as focusing on areas where he/she needs more help.

 This is an investigational study. CTP and assessment appointments will be scheduled on days
 that your child is already in the clinic or inpatient, as often as possible. About 30
 children will take part in this study. All will be enrolled at M. D. Anderson.
Inclusion Criteria:

 1. Eligibility criteria to participate in the study are: at least 6-years-old.

 2. Enrolled in school or homebound instruction in a grade Kindergarten through 12th.

 3. A diagnosis of leukemia, lymphoma, or brain tumor (e.g., primary brain tumors,
 leptomeningeal infiltration, or metastases) that requires treatment of the CNS
 (surgery, CRT, and/or chemotherapy).

 4. Within 2 months to 14 months after beginning treatment for cancer.

 5. Full scale IQ > or = 70.

 6. English-speaking. (This is defined as the ability to appropriately respond to test and
 training materials.)

 Exclusion Criteria:

 1) A major physical, neurologic, or psychiatric condition that would preclude participation
 in the research program. The functional criteria for exclusion is inability to perceive and
 comprehend training materials and therapeutic interventions.