Temporally Optimized Patterned Stimulation (TOPS®) Deep Brain Stimulation (DBS) for the Treatment of Parkinson's Disease
Temporally Optimized Patterned Stimulation (TOPS®) Deep Brain Stimulation (DBS) for the Treatment of Parkinson's Disease
This study will test newly developed stimulation settings called Temporally Optimized
 Patterned Stimulation or TOPS, which can be used with an already implanted deep brain
 stimulation system. The purpose of this study is to determine if TOPS DBS can improve
 Parkinson's symptoms compared to Standard DBS.
Key Inclusion Criteria:

 -  Diagnosed with Parkinson's disease

 -  Implanted with unilateral or bilateral subthalamic DBS System to treat Parkinson's
 disease at least 6 months prior to the study date

 -  Responds to DBS by having demonstrated a minimum improvement in motor score

 Key Exclusion Criteria:

 -  Score of <24 on the Mini Mental Status Exam

 -  Abuses drugs or alcohol

 -  Pregnant

 -  History of significant cardiovascular, pulmonary, musculoskeletal, metabolic, or other
 neurological disorders (i.e. epilepsy, stroke)

 -  Prisoners, employees that report to investigators