Health Behavior Feedback Study for Veterans With Hepatitis C
Health Behavior Feedback Study for Veterans With Hepatitis C
The purpose of this study was to explore whether a brief (3 session) intervention would
 impact health behavior of veterans with hepatitis C. The main focus of the intervention was
 on reduction of heavy drinking with patients who have liver disease. Other study goals were
 to increase the likelihood that patients would seek out substance use treatment and/or
 hepatitis C health care services. The study also tested the use of a liver function test
 called CDT/GGT in detecting heavy drinking. The main hypothesis was that a 3 session
 intervention with personalized feedback about health behavior would result in a reduction in
 alcohol use and increased use of substance use treatment and hepatology health care.
OBJECTIVES: To establish the feasibility of a brief intervention for hepatitis C+ (HCV)
 patients who drink alcohol. The primary aim was reduction in alcohol use, which is known to
 be hazardous for patients with chronic HCV infection. Secondary aims were: 1) to increase
 patient engagement in substance use disorder (SUD) treatment, 2) to explore patient
 engagement in HCV specialty care, treatment acceptability, and impact on other health-related
 behaviors, and 3) to examine pre-post intervention differences in relation to report of
 alcohol use and to explore whether the CDT/GGT merits tracking to detect heavy drinking in
 this population, given hepatic pathology.

 DESIGN: Randomized controlled trial with six-week and 12-week post-baseline assessment
 follow-up. The control group was offered the brief intervention at completion of the 12-week
 post-baseline follow-up.

 PARTICIPANTS: We had anticipated recruiting 60 veterans who were HCV+, referred for HCV
 specialty care (education or treatment evaluation), and who met criteria for hazardous
 alcohol use. Due to problems with recruitment, only 12 veterans participated in the study
 (see below).

 RECRUITMENT: We started regular study recruitment September 27, 2004 but study recruitment
 was much slower than anticipated. Despite multiple modifications to change our recruitment
 eligibility criteria, we enrolled only twelve subjects (N=12). Due to this ongoing
 recruitment problem, we decided to end study enrollment on 9/30/05 with follow-up completion
 in December 2005. Despite an extension of the Alcoholic Beverage Medical Research Foundation
 grant, there was no progress in identifying an alternative recruitment or developing an
 appropriate follow-up study.

 MEASURES: Baseline assessment included demographic information, the Alcohol Use Disorders
 Identification Test (AUDIT), Form - 90 (recent alcohol and drug use), a DSM-IV SUD criteria
 checklist, a Health Behavior Questionnaire, and the K-10 (brief measure of psychological
 distress). For brief intervention feedback, the Short Inventory of Problems (negative
 consequences of alcohol use), the SOCRATES (stage of readiness to change), blood draw for
 liver function tests, and two brief measures of neuropsychological functioning were
 administered. VA treatment utilization data (SUD and specialty HCV treatment attendance) was
 obtained. Follow-up sessions also included measures of treatment acceptability and concept
 retention.

 INTERVENTION: Participants in the brief intervention condition received personalized feedback
 and encouragement to explore ambivalence about change and treatment in three sessions.
 Feedback and interventions were tailored to individuals' health-related behavior with
 emphasis on alcohol use.

 COMPLETION DATA: Ten participants were randomized to receive the feedback session and two
 were randomized to receive the treatment as usual or control group. Of the twelve
 participants enrolled, eight individuals (7 randomized, 1 control) completed all study
 sessions, one completed 2 of the 3 required sessions (1 control), and three who received the
 intervention completed only the initial baseline session.

 DEMOGRAPHICS: We had eleven men and one female enroll in the study. The mean age of our
 participants was 55 years old. Five subjects identified themselves as African American or
 Black while seven identified themselves as Caucasian or White. Half (N=6) of the group were
 divorced and 42% (N=5) of the group were unemployed at the time they enrolled in the study.
 Over half (58%) of the subjects had completed some college in their lifetime.

 SUD INFORMATION AND FEEDBACK: All subjects receiving the feedback sessions received a
 Personal Feedback Report at their first intervention session. This report incorporated data
 from the SOCRATES, SUD criteria checklist, Form 90 - revised, the SIP, and the Health
 Behavior Questionnaire which was collected at an earlier baseline session. For those
 receiving the feedback sessions (N=10), all had a primary diagnosis of alcohol dependence,
 while eight also endorsed use of additional substances (cocaine, opiates, cannabis and/or
 amphetamines).

 Compared to individuals of the same gender in the population, the mean percentile rank of
 drinking norms was 97.5 (sd = 3.26). Based on data from the Form- 90 regarding typical weekly
 drinking patterns and levels of intoxication, the subjects in the feedback session had a
 reported mean Blood Alcohol Concentration (BAC) level of .13 (sd =.13) in a typical week,
 with a mean typical heavy day of drinking reaching a BAC of .23 (sd = .30). Subjects received
 feedback on the common effects of different levels of intoxication and how their
 self-reported drinking compared.

 Besides receiving feedback on their drinking and the associated negative consequences,
 subjects also received feedback on their reported drug use. Cocaine and cannabis were the
 most frequently used drugs within the 30 days prior to the baseline, with subjects reporting
 mean use of 3.4 (sd = 6.7, sd =6.3, respectively) days out of 30. Subjects also received
 feedback on their smoking habits. Of the ten non-randomized subjects nine reported some
 tobacco use at baseline and no one reported decreased or discontinued use of tobacco after
 receiving the intervention.

 TREATMENT ACCEPTABILITY: After the follow-up appointments we asked subjects (N=7) to rate
 their acceptance of the study intervention sessions on 14 different items ranging from their
 feelings of the discussions sessions to ratings on the therapist they met with throughout the
 study. Items were scored on a scale of 1-7. At the final follow-up 71% (N=5) reported the
 sessions as being valuable and easy to complete. Ninety percent (N=6) of the subjects who
 completed follow-up also reported the therapist as being helpful and caring towards them in
 the sessions.
Inclusion Criteria:

 1. Positive serology for current infection by hepatitis C viremia by PCR confirmation
 test;

 2. Current alcohol use (past 30 days) as indicated by self-report (using AUDIT- C
 questions);

 3. Meets hazardous alcohol use criteria as measured by the Alcohol Use Disorders
 Identification Test.

 Criteria per (National Institute on Alcohol Abuse and Alcoholism, 1995):

 1. for women, 7 or more drinks per week or 4 or more drinks per occasion;

 2. for men, 14 or more drinks per week or 5 or more drinks per occasion;

 4. Not currently engaged (past 30 days) in VA specialty substance use disorder treatment
 or mutual help groups like AA/NA.

 Exclusion Criteria:

 1. Abstinent from alcohol use in last 30 days as indicated by self-report or less than
 hazardous use according to criteria listed above by the AUDIT.

 2. Patient is already engaged (past 30 days) in specialty substance use disorder
 treatment or attends self-help groups.