Genetic Polymorphisms of Interleukin-1B and TNF-A and HBV-Related Hepatocellular Carcinoma
Genetic Polymorphisms of Interleukin-1B and TNF-A and HBV-Related Hepatocellular Carcinoma
By detecting polymorphisms of IL-1β and TNF-α,this study aims to find the effects of cytokine
 gene polymorphisms(and their interaction) on susceptibility and severity of HBV-related HCC.
Hepatitis B virus (HBV)infection is the major risk factor for chronic liver disease and
 hepatocellular carcinoma (HCC). Host immunogenetic factors contribute to HBV-associated liver
 damage and/or carcinogenesis. Variant cytokine alleles, including tumor necrosis
 factor-α(TNF-α)and interleukin-1β(IL-1β), might contribute to interindividual difference in
 inflammatory responses and account for heterogeneous disease outcome of infectious disease.

 By detecting polymorphisms of IL-1β and TNF-α,this study aims to find the effects of cytokine
 gene polymorphisms(and their interaction) on susceptibility and severity of HBV-related HCC.
Inclusion Criteria:

 -  HBsAg-positive patients

 Exclusion Criteria:

 -  HBsAg-negative patients