Prevalence of Congenital Long QT Syndrome and Acquired QT Prolongation in a Hospital Cohort
Prevalence of Congenital Long QT Syndrome and Acquired QT Prolongation in a Hospital Cohort
The Long QT syndrome is associated with potentially life-threatening cardiac arrhythmias as
 ventricular tachycardia (Torsade de pointes) as well as ventricular fibrillation, and might
 lead to syncope as well as sudden cardiac death (1). Good results have been achieved by
 treating patient at risk with beta blockers and implantable cardiac defibrillator (ICD). It
 is therefore important to diagnose the condition as early as possible as the disease is
 treatable (2).

 Prolonged QT duration might also be induced by the intake of numerous pharmaceutical
 substances, as well as with electrolyte disturbances, which also increases the risk of
 life-threatening cardiac arrhythmias. Furthermore, congenital LQTS can arise from mutations
 in one of at least 13 different genes. Many of these genes encode proteins which are
 constituents of ion channels. The genetically defined long QT syndrome has autosomal dominant
 (Romano Ward Syndrome) or autosomal recessive (Jervell and Lange-Nielsen Syndrome)
 inheritance.

 In this study we are using the hospital ECG database obtained with the GE Marquette 12SL ECG
 Analysis Program® at Telemark Hospital Skien recorded between March 2004 and April 2014. This
 database stores approximately 200 000 ECG recordings from 60 000 unique patients.

 By using the search algorithm in the MUSE ECG database, 2398 recordings have been be
 identified from 1603 patients where the corrected QT time is longer than 500 ms, and QRS is
 less than 120 ms.

 ECG recordings with QT intervals longer than 500 ms represents less than 1% of the population
 (5). Individuals having these recordings are selected for extensive clinical follow up. The
 patients will be offered the opportunity to have genetic analysis performed in order to
 distinguish between inherited or acquired long QT syndrome. The appropriate treatment will be
 initiated according to guidelines for patients with inherited QT syndrome. For patients with
 aquired long QT syndrome substitution of unfavourable pharmacotherapy or correction of
 electrolytes shall be performed in order to reduce their risk of cardiac arrhythmias.

 A T wave morphology score gives independent prognostic information useful for risk
 stratification. The purpose of this substudy is to examine if the T wave morphology score
 applied on the 1531 patients ECGs with QTc >500 ms, has independent prognostic value in this
 cohort.
2. PURPOSE OF THE STUDY

 The study has the intention to:

 -  Identify patients with inherited LQTS in order to give them optimal treatment.

 -  To identify patients with acquired QT prolongation in order to possibly correct
 electrolyte disorders and therapeutically prescriptions in order to minimize the chance
 of life-threatening arrhythmias.

 -  To analyse to what extend a specific reason for QT prolongation can be found in patients
 with heart rate adjusted QT prolongation, or to which extend the QT prolongation without
 syncope, or family history of sudden cardiac death, is an unspecific finding.

 -  To analyse time dependent risk of patients with QT prolongation related to underlying
 disease

 -  To analyse to what extend genetic variations might predispose for acquired QT
 prolongation.

 -  To compare life expectancy of patients with QT prolongation related to case control
 patients with out QT prolongation.

 -  To implement rapid reaction on newly diagnosed QT prolongation, and follow up of
 survival after implementation of improved care.

 -  To examine if the T wave morphology score applied on patients ECGs with QTc >500
 ms, has independent prognostic value in this cohort.
Inclusion Criteria:

 QT time in EKG more Tham 500 ms -

 Exclusion Criteria:

 Patient refuses to be a part of the study registry