Investigation of the Serum Mucoprotein 3 (MUC3) Protein Levels in Gestational Hypertensive Disease
Investigation of the Serum Mucoprotein 3 (MUC3) Protein Levels in Gestational Hypertensive Disease
Hypertensive diseases of pregnancy are one of the most frequently encountered reasons for
 maternal and neonatal morbidity and mortality. The excretion of high levels of mucoprotein
 takes part in the pathogenesis of preeclampsia through restraining trophoblast invasion. This
 study aimed to investigate levels of serum mucoprotein three in hypertensive diseases of
 pregnancy. This study included a total of eighty cases that 20 normal pregnancy, 20
 gestational hypertension, 20 preeclampsia, and 20 HELLP syndrome patients from June 2010-
 January 2011.
Hypertensive diseases of pregnancy are one of the most frequently encountered reasons for
 maternal and neonatal morbidity and mortality. The excretion of high levels of mucoprotein
 takes part in the pathogenesis of preeclampsia through restraining trophoblast invasion. This
 study aimed to investigate levels of serum mucoprotein three in hypertensive diseases of
 pregnancy. This study included a total of eighty cases that 20 normal pregnancy, 20
 gestational hypertension, 20 preeclampsia, and 20 HELLP syndrome patients from June 2010-
 January 2011. This is the first study measuring levels of serum mucoprotein three in
 gestational hypertensive disease. MUC3 levels showed a distinctive increase in hypertensive
 diseases of pregnancy compared with the pregnant control group. As a result, it is found that
 plasma mucoprotein 3 levels increase as the severity of hypertensive diseases of pregnancy
 increases; and plasma mucoprotein 3 could be a precursor for the evaluation of the severity
 of the disease.
Inclusion Criteria:

 -  To accept the consent to participate in the research and sign the form,

 -  According to ACOG 2002, pregnancy meets the criteria of hypertensive diseases [1], The
 diagnosis of HELLP syndrome was made according to the criteria described by Sibai.
 These; abnormal peripheral smear, schistocyte in the peripheral smear, lactate
 dehydrogenase > 600 U / L, hemolysis, total bilirubin> 1.2 mg / dl, AST> 70 U / L,
 platelet count <100,000mm3.

 -  When the demographic characteristics and CVs of all cases were questioned in the
 initial evaluation, not having chronic inflammation or acute infection, not having any
 systemic disease, recurrent pregnancy loss, thrombophilia, antiphospholipid antibody
 syndrome,

 -  Not smoking, No history of cancer, No multiple pregnancies

 -  Not using antihypertensive, anticoagulant, NSAID, corticosteroid or antiplatelet and
 antiepileptic drugs

 Exclusion Criteria:

 -  using antihypertensive, anticoagulant, NSAID, corticosteroid or antiplatelet and
 antiepileptic drugs

 -  smoking,history of cancer, multiple pregnancies