Abnormal Coronary Vasomotion in Patients With Suspected Coronary Artery Disease (CAD)
Abnormal Coronary Vasomotion in Patients With Suspected Coronary Artery Disease (CAD)
In patients with chest pain and/or shortness of breath coronary artery disease (CAD) is
 suspected depending on the pattern of symptoms and the electrocardiogram (ECG). Coronary
 angiography is the method of choice to verify this suspicion. If the patient coronary
 arteries on coronary angiography are totally normal or unobstructed, one can only speculate
 if the patients' discomfort is from the heart or not. A possibility to get further
 information about the healthiness of the coronary arteries is the acetylcholine test
 (ACH-test). When injecting this natural, body produced-substance into the coronary arteries
 one can test if the vessels develop coronary spasm which can be the reason for the patient's
 symptoms. The investigators therefore use this test in this study to look for coronary spasm
 in patients with suspected CAD but normal/unobstructed coronary arteries. In case of a
 positive test, the patient profits from having found a cause for his/her symptoms making
 treatment with special tablets possible. Furthermore, the investigators want to analyze blood
 samples of every patient to look for signs of inflammation that seem to be linked with
 coronary spasms. On the basis of these results the ACH-test could probably be avoided in the
 future.
Inclusion Criteria:

 -  Adults between 35 and 95 years old with angina pectoris and/or dyspnea suggestive of
 coronary artery disease with non-invasive proof of coronary ischemia or high pre-test
 probability for CAD who will be referred for coronary angiography

 -  Serum creatinine < 1,4 md/dl

 -  Left ventricular ejection fraction > 50%

 Exclusion Criteria:

 -  Patients under 35 years and above 95 years of age

 -  Severe chronic obstructive pulmonary disease (contraindication for
 acetylcholine-testing)