Multifunctional Magnetic Resonance Imaging in Predicting Breast Lesions in Women Undergoing Mastectomy for Breast Cancer
Multifunctional Magnetic Resonance Imaging in Predicting Breast Lesions in Women Undergoing Mastectomy for Breast Cancer
RATIONALE: Diagnostic procedures, such as multifunctional magnetic resonance imaging, may
 help doctors learn the extent of disease and plan the best treatment.

 PURPOSE: This clinical trial is studying how well multifunctional magnetic resonance imaging
 works in predicting breast lesions in women undergoing mastectomy for breast cancer.
OBJECTIVES:

 -  To determine the accuracy of multifunctional magnetic resonance (MR) in detecting,
 localizing, and characterizing satellite lesions in relation to an index breast tumor in
 order to improve definition of clinical target volume after local excision.

 OUTLINE: Patients receive an injection of gadolinium chelate and undergo multifunctional
 magnetic resonance (MR) imaging, including dynamic contrast-enhanced MR, hydrogen-MR
 spectroscopy, and diffusion-weighted MRI, of the ipsilateral breast within 4 weeks before
 surgery. Patients undergo a mastectomy as planned. The resected specimen is photographed, and
 a histopathological analysis is performed consisting of the size and grade (if pre-invasive
 or invasive disease) of each satellite lesion, classification of benign satellite lesions,
 dimensions of each lesion, distance from the edge of the index tumor to the center of each
 satellite lesion, and the distance from the center of the surface of the nipple to the center
 of each lesion.
DISEASE CHARACTERISTICS:

 -  Biopsy-confirmed invasive ductal carcinoma of the breast

 -  Unifocal disease as defined by clinical examination, mammography, and ultrasound

 -  Patient must be proceeding to mastectomy

 -  Hormone receptor status unknown

 -  No T4d or multifocal disease (as defined on conventional imaging)

 -  Index tumor ≤ 4 cm in diameter

 PATIENT CHARACTERISTICS:

 -  Menopausal status not specified

 -  Female

 -  No claustrophobia

 -  No cup size of DD or greater

 PRIOR CONCURRENT THERAPY:

 -  No prior surgery to ipsilateral breast

 -  No prior neoadjuvant chemotherapy

 -  No prior ferromagnetic implants