The Effects of Estrogen on Cognition in Girls With Turner Syndrome
The Effects of Estrogen on Cognition in Girls With Turner Syndrome
The development of the brain in females is a result of a combination of factors. During
 puberty estrogen plays a role in influencing brain development. Cultural and environmental
 factors also play a role in the development of the brain.

 Female patients with Turner syndrome lack the ability to produce estrogen due to undeveloped
 ovaries. Therefore, Turner syndrome is the perfect condition to study how estrogen (or the
 lack of estrogen) influences a person's behavior and thinking.

 This study will compare cognitive differences (visual motor skills, visual-spatial,
 psychosocial behavior, and visual memory) of patients with Turner syndrome to normal patient
 controls. Researchers will use the Weschler Intelligence Scale for Children-Revised (WISC-R)
 along with other tests and scales to measure different aspects of the patient's cognitive
 ability. In addition the study will review patients with Turner syndrome who previously
 received estrogen replacement as infants and children in a related research study.

 Researchers hope to demonstrate that estrogen replacement will improve cognition and behavior
 in girls with Turner syndrome.
Estrogen influences brain development in females at puberty. Environmental and cultural
 factors interact with the biological effects of estrogen on the brain and consequently on
 cognition and behavior. Turner syndrome females lack endogenous estrogen as a result of
 dysgenetic ovaries. Turner syndrome therefore represents a unique, estrogen-deficient model
 in which to study the biological effects of estrogen on cognition and behavior. The specific
 aims of this project are to: 1) document further, the cognitive differences between girls
 with Turner syndrome at ages 5 to adult (less than or equal to age 50) versus age-matched,
 female controls. 2) to examine the differential effects of continuous estrogen replacement in
 infancy and in early childhood on cognitive and social function in a unique, previously
 approved, randomized, double-blind, placebo-controlled, treatment trial (87-CH-0152).
 Specifically, we hypothesize that estrogen replacement in early childhood will reduce the
 cognitive deficits of girls with Turner syndrome. In addition, we hypothesize that the degree
 of socialization ability in these girls will correlate with social-behavioral and social
 recognition ability. Finally, we hypothesize that earlier (infancy to 8 years) and longer
 estrogen replacement will result in less impairment of visual-motor ability, visual-spatial
 ability, socialization ability, and affective competence compared to later (9 to 12 years)
 estrogen replacement in girls with Turner syndrome.

 Children with Turner syndrome and controls will be tested in the Outpatient Departments at
 the two approved sites of protocol 87-CH-0152; the NIH and Thomas Jefferson University.
INCLUSION CRITERIA:

 Patients will include girls and women ages 5-50 yr with the diagnosis of Turner syndrome
 based on absence of all or part of one of the X chromosomes.

 Control subjects must be within +/- 2SD for height and weight and have normal intelligence
 and educational achievement.

 Biological parents (both male and female) of TS subjects may be included in this study, but
 only to have blood drawn for genetic testing in order to determine the origin of the
 X-chromosome of their daughters.

 EXCLUSION CRITERIA:

 Those with severe physical or neurocognitive impairment, preventing accurate completion of
 the cognitive tasks, will be excluded.

 Normal subjects who have qualified for or participated in gifted and talented or remedial
 education programs.