The Effect of Probiotics on the Clearance of the Human Papillomavirus and on Cytological Lesions Caused by the Virus
The Effect of Probiotics on the Clearance of the Human Papillomavirus and on Cytological Lesions Caused by the Virus
Aim: In this project proposition the investigators would like to examine the effect of immune
 modulation by probiotics on the clearance of HPV-infections.

 This study provides a model for viral infection but also for cancer precursors. This would be
 an excellent model (and the only possible short-term model) to examine an effect on cancer
 precursors. Cancer precursors (cytological abnormalities such as L-SIL) are a scientifically
 accepted surrogate endpoint for cervical cancer, for example in HPV-vaccine studies.

 Research question: Does daily intake of probiotics lead to a better immune-response in
 HPV-infected women, i.e. does it facilitate clearance of the virus and/or regression of
 cytological lesions?
Inclusion Criteria:

 -  women with a new LSIL diagnosis an HPV positivity on PAP smear

 Exclusion Criteria:

 -  women over 65

 -  immunocompromised patients (because of disease or drugs)