Metabolic Syndrome and Sims Score
Metabolic Syndrome and Sims Score
SiMSscore was used as a simple and accurate method for Quantifying Metabolic Syndrome in
 adults , Developed siMS score was calculated using formula: siMS score = 2*Waist/Height +
 Gly/5.6 + Tg/1.7 + TAsystolic/130-HDL/1.02 or 1.28 (for male or female subjects,
 respectively),However studies on siMSscor in pediatric was done .

 PsiMSscore(pediatric sims score) calculated using formula: (2xWaist/Height) +
 (Glucose(mmol/l)/5.6) + (triglycerides(mmol/l)/1.7) + (Systolic
 BP/130)-(HDL(mmol/l)/1.02(Soldatovic etal;2016).
Metabolic Syndrome (MetS) is defined as a cluster of cardio metabolic risk factors that
 include central obesity low levels of high-density lipoprotein-cholesterol (HDL-C),
 hypertriglyceridemia, hypertension, and hyperglycaemia. Metabolic changes in childhood track
 into adulthood, predisposing these individuals to type 2 diabetes, and cardiovascular
 diseases.

 The underlying prevalence of MetS in adolescents depends on the set of MetScri:eria used,
 with overall ranges in the US from 1.2%-9.8% using modified ATP-III criteria (Adult Treatment
 PanelII) to 4.5%-8.4% using the IDF adolescent criteria . Assessments among school-aged
 children and early adolescents islower (0.2%-1.2%) which is likely because of the strong
 effects of puberty on insulin resistance.

 There is no consensus regarding the diagnosis of metabolic syndrome in children and
 adolescents. It is evident that each component of the syndrome must be identified as early as
 possible in order to prevent definitive lesion Pediatric and adolescent metabolic syndrome
 (MetS) criteria adapted from the National Cholesterol Education Program Adult Treatment Panel
 III (ATP lll),

 1. Central Obesity (WC): WC ≥ 90th percentile .

 2. High BP (mmHg) : Systolic or diastolic DBP≥ 90% for age, sex, height

 3. High Triglycerides (mg/dL) : TG ≥ 110 mg/dL (≥1.24 mmol/L) .

 4. HDL ≤ 40 mg/dL(<1.03 mmol/L).

 5. High Fasting Glucose :≥100 mg/dL (5.6 mmol/L) or known T2DM. Individuals need to have at
 least three abnormalities in MetS components to be classified as havingMetS SiMSscore
 was used as a simple and accurate method for Quantifying Metabolic Syndrome in adults ,
 Developed siMS score was calculated using formula: siMS score = 2*Waist/Height + Gly/5.6
 + Tg/1.7 + TAsystolic/130-HDL/1.02 or 1.28 (for male or female subjects,
 respectively),However studies on siMSscor in pediatric was done .

 PsiMSscore(pediatric sims score) calculated using formula: (2xWaist/Height) +
 (Glucose(mmol/l)/5.6) + (triglycerides(mmol/l)/1.7) + (Systolic BP/130)-(HDL(mmol/l)/1.02
Inclusion Criteria:

 -  All obese patients aged from 7 to 17 years old.

 Exclusion Criteria:

 -  All obesechildren

 -  With endocrial and syndromatic obesity, (Endocrinal disease as hypothyroidism and
 Cushing's syndrome etc, syndromic obesity asPrader-Willi syndrome
 ,Alstrom-Hallgren syndrome, Bardet-Biedl syndrome,
 Beckwith-Wiedemansyndrome,etc…….)

 -  Children on medications that affect lipid profile that include (β-Blockers
 ,Amiodarone ,Loop diuretics, Thiazide diuretics (high dose) ,Sodium-glucose
 co-transporter 2 (SGLT2) inhibitors ,Steroid Hormones/Anabolic Steroids,
 Antiviral Therapy ,Immunosuppressants ,Centrally Acting Medications as
 Anticonvulsants).