Research on Expecting Moms and Sleep Therapy
Research on Expecting Moms and Sleep Therapy
The overarching goal is to utilize a randomized control design to examine efficacy of
 web-based cognitive behavior therapy (CBT-I) plus treatment as usual compared to treatment as
 usual alone for insomnia and depression outcomes among pregnant women with insomnia at high
 risk for depressive relapse/recurrence (n=208).
Depression in pregnancy ("antenatal depression") is common and associated with acute and
 long-lasting adverse consequences for women and offspring. Insomnia is a risk factor for
 depression in general populations, and poor sleep quality is linked to increased depression
 among antenatal women. There have been no randomized control trials investigating
 nonpharmacological insomnia treatment on antenatal insomnia and depression outcomes. Many
 pregnant women use the Internet to seek pregnancy-related information, and report a
 preference for mental health care within the home or obstetrics clinic. The overarching goal
 is to utilize a randomized control design to examine efficacy of web-based cognitive behavior
 therapy for insomnia and depression outcomes (CBT-I) compared to treatment as usual (TAU)
 among pregnant women at risk for depression (n=208). Participants will be recruited
 nationally to complete study questionnaires at five timepoints through pregnancy and 6 months
 postpartum. Participants randomized to CBT-I will receive access to 6 weekly CBT-I
 web-sessions and treatment as usual. Participants randomized to treatment as usual will
 receive usual care and will be given access to Sleepio upon study completion. Our specific
 aims are:

 1. To evaluate feasibility and acceptability of CBT-I for pregnant women.

 2. To test whether participants receiving CBT-I show improvement in sleep compared to TAU
 participants.

 3. To examine whether participants randomized to CBT-I will experience improved depressive
 outcomes compared to TAU.

 4. To explore the impact of CBT-I on birth outcomes.

 There is strong conceptual basis to predict the potential benefit of this approach for
 pregnant women. Targeting risk factors for antenatal depression may have significant public
 health benefits.
Inclusion Criteria:

 1. pregnant up to 28 weeks gestation,

 2. 18 years of age or older,

 3. Meets DSM-5 criteria for Insomnia disorder as determined by the Sleep Condition
 Indicator or ISI ≥ 11

 4. regular access to a web-enabled computer, tablet, or smart phone.

 Exclusion Criteria:

 1. Probable major depression (EPDS ≥ 15),

 2. self-reported bipolar disorder,

 3. self-reported history of psychosis,

 4. active suicidality defined as scoring > 1 on EPDS item 10 or report of a specific
 suicide plan or recent attempt,

 5. shift work employee,