Prognosis Value of Transient Elastography and Non-invasive Markers of Fibrosis in Patients With Chronic Liver Disease
Prognosis Value of Transient Elastography and Non-invasive Markers of Fibrosis in Patients With Chronic Liver Disease
The aim of this prospective study was to compare the 5-year prognostic value of transient
 elastography (TE), FibroTest (FT), APRI , FIB-4, Lok, and Child-Pugh scores for predicting
 survival and complications of cirrhosis in patients with chronic liver diseases.
A total of 1616 patients with chronic hepatitis C was included. At 5 years, 79 patients were
 dead (39 liver-related deaths) and 16 patients had liver transplantation. Overall survival
 was 91.7% and survival without liver-related death 94.4%. Survival was significantly
 decreased in patients diagnosed with severe fibrosis, whatever the non-invasive method used.
 All these methods were able to predict a shorter survival in this large population. Patients
 had their prognosis decreased as liver stiffness increased. By multivariate analysis, only
 FibroTest > 0.74 (OR 4.41, 95%CI 1.62-12.01, p=0.004) was associated with overall survival,
 and liver stiffness > 9.5 kPa (OR 4.71, 95%CI 1.06-21.01, p=0.04) associated with
 liver-related death.
Inclusion Criteria:

 -  chronic hepatitis C

 -  chronic hepatitis B

 -  alcoholic liver disease

 -  non alcoholic steatohepatitis

 Exclusion Criteria:

 -  ascitis