Effects of Octanoic Acid for Treatment of Essential Voice Tremor
Effects of Octanoic Acid for Treatment of Essential Voice Tremor
Essential voice tremor is a neurological condition that produces a regular, shaking quality
 in the voice. One form of drug treatment that produces some improvement in tremor of the
 hands is octanoic acid, which is a food additive that is similar to alcohol. Research
 suggests that octanoic acid may reduce tremor in the hands/arms with few side effects and no
 intoxication effects. This study will determine whether octanoic acid may be useful for
 reducing tremor when it affects the voice. Researchers are hypothesizing that octanoic acid
 will reduce the effects of tremor on the voice.
Background:

 -  Essential tremor of the voice produces regular shaking and hoarseness in the voice,
 making it difficult speech difficult to understand

 -  Several previous studies have found that octanoic acid and octanol, which are related to
 alcohol, can improve tremor in some people without producing many side effects and
 without producing intoxication

 -  Researchers are interested in determining whether octanoic acid can improve tremor that
 affects the voice

 Objectives:

 -  To determine the effects of octanoic voice using voice recordings and listener ratings
 of voice

 -  To determine the effects of octanoic acid on level of voice disability experienced by
 people with essential voice tremor
Inclusion Criteria:

 -  Participants have a diagnosis of essential voice tremor and show signs of tremor
 during the endoscopy examination (when pictures of the voice box are obtained)during
 screening appointment

 -  Participants show measurable voice tremor from recordings of the voice during
 screening appointment

 Exclusion Criteria:

 -  Participants have a diagnosis or show signs of Parkinson's Disease or another
 non-essential tremor movement disorder

 -  Participants have a diagnosis or show signs of spasmodic dysphonia (a different
 neurological voice disorder)

 -  Participants have a diagnosis of a severe, non-stable medical condition, such as
 kidney or liver failure, severe heart disease, severe lung disease, severe metabolic
 disease, uncontrolled hyperthyroidism, or other life-threatening disease such as
 active cancer

 -  Participants have a diagnosis of diabetes mellitus

 -  Participants are unable to suspend/stop a medication that they are currently taking
 for tremor or voice disorder for 12 weeks to complete this study

 -  Participants have a dependence on alcohol or allergy to alcohol

 -  Participants are pregnant or lactating

 -  Participants have an allergy to soy

 -  Participants have Irritable Bowel Syndrome