Prediction Model for Recanalization Outcome Evaluation of Ischemic Stroke Using Multimodal CT
Prediction Model for Recanalization Outcome Evaluation of Ischemic Stroke Using Multimodal CT
To assess the effect of novel imaging biomarkers/ imaging patterns based on multi-model CT on
 patients selection/stratification for therapy decision support in large vessel acute ischemic
 stroke
Patients Patients with cerebral ischemia sympton of anterior circulation or posterior
 circulation onset in 24 hours were included. A neurological evaluation (Modified Rankin Scale
 and NIHSS); physical examination, including measurement of weight (kg) and vital signs
 (supine systolic and diastolic blood pressure, heart rate) ; time from sympton onset to
 enrollment were recorded.

 Imaging protocols:

 CT scan protocols: No enhancement computed tomography(NECT) , computed tomography
 angiography(CTA), computed tomography perfusion(CTP)

 Contrast agent:

 CTA: Omniscan 40-50ml, 5ml/s; saline solution 50ml, 5ml/s

 CTP: Omniscan 50ml, 5ml/s; saline solution 50ml, 5ml/s

 Imaging evaluation:

 Treatment:

 Intravenous recombinant tissue plasminogen activator(rtPA), endovascular therapy and
 conventional treatment including neuro protection, ante-platelet and statin.

 Follow up:

 Five days, one month, three months and one year after imaging follow up and clinical stroke
 event and modified Rankin Scale(mRS).
Inclusion Criteria:

 -  Cerebral ischemic sympton of anterior circulation onset in 24 hours

 -  Large vessel anterior and posterior circulation occlusion on MR or CT angiography

 -  Minor stroke (NIHSS≤3) and TIA

 -  All CT examination performed according to study protocol

 -  Signed informed consent obtained from the patient or patient's legally authorized
 representative

 -  Having complete medical history and clinical follow up

 -  Imaging data can be processed

 Exclusion Criteria:

 -  Acute intracranial hemorrhage

 -  Pre-existing medical, neurological or psychiatric disease that would confound the
 neurological, functional, or imaging evaluations

 -  Pregnancy

 -  Known allergy to iodine previously refractory to pretreatment medications

 -  Renal Failure (serum creatinine > 2.0 or Glomerular Filtration Rate [GFR] < 30)

 -  History of sever kidney disease as an adult, including tumor or transplant surgery, or
 family history of kidney failure

 -  Severe cardiac insufficiency