Ethosuximide and Pentoxifylline in the Treatment of Abdominal Pain Related to Irritable Bowel Syndrome
Ethosuximide and Pentoxifylline in the Treatment of Abdominal Pain Related to Irritable Bowel Syndrome
Ethosuximide and pentoxifylline in the treatment of abdominal pain related to irritable bowel
 syndrome
Ethosuximide and pentoxifylline in the treatment of abdominal pain related to irritable bowel
 syndrome: Does this add to current treatment?
Inclusion Criteria:

 -  • Age ≥ 18 years,

 -  Man and Women, Negative pregnancy test and effective contraception,

 -  IBS defined by the Rome criteria IV

 -  During the previous seven days the inclusion visit, average numeric rating scale
 (NRS) pain ≥ 4.

 -  IBS Treatment stable for 1 month

 Exclusion Criteria:

 -  • Breastfeeding

 -  Diabetic patients

 -  Significant liver function abnormalities (transaminases> 3N, cholestasis) and
 moderate renal disease (MDRD <60 ml / min)

 -  Addiction to alcohol and / or drugs,

 -  Antiepileptic drugs taken (epilepsy or chronic pain)

 -  Chronic pain of greater intensity than that related to IBS,

 -  Known Allergyto succinimides (ethosuximide, methsuximide, phensuximide) and
 pentoxifylline.

 -  History or current severe depression (hospitalization, long-term antidepressant
 treatment)

 -  Psychotic disorders,