Dietary Milled Seed Mix in Patients With Non-Hodgkin Lymphoma
Dietary Milled Seed Mix in Patients With Non-Hodgkin Lymphoma
Recent literature data suggest beneficial effects of dietary fats in patients with cancers,
 in particular polyunsaturated fatty acids (PUFAs). Milled mix of flax, sesame and pumpkin
 seeds provides a high amount of PUFAs and a desirable n-6/n-3 PUFAs ratio.
Cancers are characterized by inflammation and alternations in lipid and fatty acid
 metabolism. Patients with non-Hodgkin lymphoma have impaired fatty acid profiles, low level
 of PUFAs, and high n-6/n-3 PUFAs ratio. Moreover, these changes are related to clinical
 outcome.

 Flax seeds, sesame and pumpkin seeds are rich sources of PUFAs. Dietary intake of milled mix
 of these seeds has been shown to decrease inflammation and improve PUFAs status in patients
 on hemodialysis and to decrease breast cancer risk.

 The study design is single-blind, controlled, randomized nutritional intervention. The
 participants are randomly assigned into intervention and control group before starting
 chemotherapy. All patients receive nutritional counseling to achieve a daily energy and
 protein intake according to recommended dietary allowances, with (intervention) or without
 (control) of milled seed mix.
Inclusion Criteria:

 -  Histologically confirmed Non-Hodgkin lymphoma

 -  Patients able to understand requirements of the study and provide written informed
 consent

 Exclusion Criteria:

 -  Previous radio- or chemotherapy

 -  Other serious chronic diseases

 -  Statin therapy

 -  Presence of allergy on any seeds

 -  Use of fat-based dietary supplements (such as fish oil, evening primrose oil etc) 3
 months prior to study