Cognitive Function After Radiation Therapy for Primary Brain Tumours
Cognitive Function After Radiation Therapy for Primary Brain Tumours
This study will assess cognitive function in patients with a primary brain tumour treated
 with radiation therapy (RT) to generate radio-sensitivity and volume effect parameters for
 the development of cognitive dysfunction. All types of brain tumours apart from glioblastoma
 will be included.
RT is fundamental in the treatment of primary brain tumours. RT contributes to improved local
 control and prolonged progression-free survival in patients with a broad range of tumour
 types. Irradiation to the normal brain may lead to cognitive impairments. Clarifying the
 nature and severity of impairment in adult RT-treated brain tumour patients, including
 region-specific effects, are important for optimal utilization of novel conformal RT
 technologies such as proton therapy.

 The study is a prospective nationwide study including approximately 300 brain tumour patients
 from the Danish Center of Particle Therapy and the four Neuro Oncology Centers in Denmark.

 The patients will be assessed with a comprehensive battery of standardized cognitive tests
 and complete a questionnaire (PRO's). They will do this prior to RT treatment and 1, 3, 5 and
 10 years afterwards. The PRO's includes measures on quality of life, fatigue, sleep,
 depression, anxiety, and socio demographics. The standardized tests are: Trail making Test
 (TMT); Hopkins Verbal Learning Test (HVLT); Controlled Oral Word Association Test (COWAT) -
 Animals and S; Coding and Digit Span from WAIS-IV. The correlation between cognitive scores
 and RT dose-volume parameters to specific areas in the brain will be tested.

 This study will elucidate the dose-response relationship in radiation-induced damage to
 substructures of the brain such as hippocampus, thalamus, temporal and frontal lobes that
 will allow the clinician to prioritize these structures in planning of proton radiotherapy.
Inclusion Criteria:

 -  18 years or older and Danish speaking.

 -  Performance status WHO 0-2

 -  Capable of cooperating on testing

 -  Tumour histology (WHO 2016 classification) of the following types: anaplastic
 astrocytoma (IDH mutant), diffuse astrocytoma (IDH-mutant), gemistocytic astrocytoma
 (IDH mutant), diffuse astrocytoma (NOS), oligodendroglioma, meningioma,
 medulloblastoma (NOS), pituitary adenoma, other brain tumours including skull base
 sarcomas

 Exclusion Criteria:

 -  Glioblastoma

 -  Performance status 3-4 (Karnofsky Performances of 60 or less)