Event Related Potentials in Borderline Personality Disorder and Major Depression
Event Related Potentials in Borderline Personality Disorder and Major Depression
This study examines whether depression in people with borderline personality disorder is
 different than depression in people without borderline personality disorder.

 Unlike people who have depression alone (i.e. without borderline personality disorder),
 people with borderline personality disorder have depressions that often do not improve with
 medications. This makes treating depression much more challenging in someone with borderline
 personality disorder than without borderline personality disorder.

 Borderline personality disorderis associated with difficulty in understanding and
 communicating feelings. Impaired emotion processing may reflect dysfunction of an area of the
 brain, the anterior cingulate.

 Depression is associated with changes in anterior cingulate activity. The investigators
 believe that when borderline personality disorder is present with depression, brain activity
 changes in the anterior cingulate will not be the same as in depressed patients without
 borderline personality disorder.

 An electroencephalogram records brain electrical activity. In this study, the investigators
 will measure electroencephalogram indices reflecting anterior cingulate activity.

 HYPOTHESIS: In this study, the investigators predict that when borderline personality is
 present with depression, electroencephalogram indices of anterior cingulate activity will be
 different from when depression is present alone (without borderline personality). This could
 help to explain why people with borderline personality have depressions that are harder to
 treat than depressions in people without borderline personality.

 The investigators also predict that electroencephalogram indices of the anterior cingulate
 will reflect emotional processing ability, as measured by validated questionnaires.
Inclusion Criteria:

 -  age between 18 and 45

 -  female

 -  noncontrols diagnosis: major depression &/or borderline personality disorder

 -  Control participants should have neither major depression or borderline pers.

 -  meet Structured Controlled Interview for DSM - II cut off scores

 -  meet Beck Depression Inventory (BDI)cut off scores

 -  meet Borderline Evaluation of Severity Over Time(BEST) cut off scores.

 Exclusion Criteria:

 -  based on having none of the below diagnoses from patient history, prior clinical
 records and based on MINI Plus International Neuropsychiatry Interview

 -  schizophrenia

 -  psychosis

 -  Attention Deficit Hyperactivity Disorder

 -  Obsessive Compulsive Disorder

 -  bipolar disorder

 -  mental retardation

 -  dementia

 -  CNS disease

 -  Post-Traumatic Stress Disorder in non-borderline personality disorder groups

 -  Recreational drug or alcohol use in the past week.