Reversal of Ventricular Remodeling With Toprol-XL
Reversal of Ventricular Remodeling With Toprol-XL
The purpose of this study is to determine whether treatment with Toprol-XL for 12 months in
 asymptomatic heart failure subjects will improve their heart structure and thus prevent the
 progression to symptomatic disease.
Inclusion Criteria:

 -  Diagnosis of stable asymptomatic heart failure.

 -  Documented ejection fraction less than 0.40.

 -  Must be able to comply with all study procedures.

 Exclusion Criteria:

 -  Taken B-blocker therapy for longer than 1 week within 6 months prior to randomization.

 -  Have heart problems that would not allow B-blocker therapy.

 -  Receiving B-blockers therapy for any medical reason including topical B-blockers that
 might cause systemic absorption (e.g., glaucoma).

 -  Undergone certain heart surgeries, such as, prior heart transplant or cardiomyoplasty.

 -  Have certain heart diseases.

 -  Pregnant or breast feeding.

 -  Unlikely to survive.