Effect of Docosahexaenoic Acid (DHA)-Enriched Human Milk in Premature Newborns
Effect of Docosahexaenoic Acid (DHA)-Enriched Human Milk in Premature Newborns
Several recent publications showed a reduction in the level of DHA and/or an increase in the
 arachidonic acid (AA)/DHA ratio in the milk of mother. We hypothesized that the
 polyunsaturated fatty acid (PUFA) status of the premature newborn fed mother's milk is
 unbalanced because the content of DHA of the milk of mother nowadays is insufficient, whereas
 scientific arguments point-out the essential role of DHA and balanced AA/DHA ratio of human
 milk to explain the beneficial role of the breast-feeding at short, medium and long term. We
 will study the benefits of DHA supplements (TG-DHA versus GPL-DHA) of mothers in PUGA status
 improvement in their premature newborn consecutive to DHA enrichment and balanced AA/DHA
 ratio of human milk. GPL-DHA should be more effective than TG-DHA by protecting both n-3 and
 n-6 fatty acids pathways.
Inclusion Criteria:

 -  Childbirth between 34 and 35 GA

 -  Breast-feeding

 -  Caucasian

 -  Affiliation to social security

 -  Obtained consent from mother, and parents for the child

 -  Mother with balanced diet

 -  No allergy to eggs

 -  Single pregnancy

 Exclusion Criteria:

 -  Allergy to egg

 -  Unbalanced diet

 -  Diabetes

 -  Known digestive disease

 -  Counter-indication with breast-feeding

 -  Cigarettes (more than 5 per day)

 -  Alcoholism (daily consumption of alcohol)

 -  Multiple pregnancy