Pancreas Registry and High Risk Registry
Pancreas Registry and High Risk Registry
The purpose of this study is to establish a registry of patients with pancreatic diseases.
 Patients included in the registry may include those with: pancreatic cancer, precancerous
 lesions of the pancreas, inflammatory lesions of the pancreas, cystic lesions of the
 pancreas, and patients at high-risk of pancreatic cancer such as those with a family history
 of pancreatic cancer or with a family history of a syndrome known to be associated with
 pancreatic cancer. Pancreatic cancer is the fourth leading cause of death from cancer in the
 United States. However, little is known about the development of pancreatic cancer and
 pancreatic diseases in individuals with the above conditions. Knowledge of how family
 history, environmental exposures, and inflammatory lesion of the pancreas contribute to the
 development of pancreatic cancer and pancreatic diseases is essential.

 You may qualify to take part in this research study because you have inflammation in the
 pancreas, a pancreatic cyst, pre-cancerous lesions of the pancreas, pancreatic cancer, a
 family history of pancreatic cancer, or a family history of a syndrome known to be associated
 with pancreatic cancer.

 We will also be collecting a blood sample from all participants for DNA isolation. Sometimes
 we are born with genes or DNA that give us an increased or decreased chance of developing an
 illness later in life. Genetic material will be isolated from your blood for further study.
 You may also choose to provide additional blood samples for serum and plasma extraction.
 Serum and plasma are components of the blood which can be used to measure indicators of
 disease in the blood, called biomarkers,for pancreatic diseases. Clinical data and biological
 specimens contained in this study may be used for a wide variety of future related studies to
 the cause, diagnosis, outcome and treatment of pancreatic cancer.

 Funds for conducting this research are provided by Mount Sinai.
The overall purpose of this research project is to establish a registry of patients with
 pancreatic diseases. Patients included in the registry may include those with: pancreatic
 cancer, precancerous lesions of the pancreas such as intraductal papillary mucinous neoplasms
 (IPMNs) and cystic lesions, inflammatory lesions and inflammation of the pancreas, and
 patients at high-risk of pancreatic cancer such as those with a family history of pancreatic
 cancer or with a family history of a syndrome known to be associated with pancreatic cancer.
 The data contained in this registry will be used to conduct research related to the risk of
 pancreatic cancer and pancreatic diseases. As this is a registry protocol, no specific
 hypotheses are to be tested.

 Specific Aims:

 1. Establish and maintain a registry of individuals and their family members who have
 pancreatic diseases and may be at increased risk of developing pancreatic cancer over
 normal population risk.

 2. Collect data and review existing data on personal and family histories, demographics,
 risk factors, and health behaviors.

 3. Use the data in the registry to conduct studies related to disease risk, prevention, and
 prognosis of pancreatic cancer and other pancreatic diseases.

 Pancreatic cancer is the fourth leading cause of death from malignancy in the United States.
 With near equivalent incidence and mortality, cure can only be achieved with surgical
 resection of an early stage lesion. Premalignant disease stages, such as IPMN, may be
 detected with noninvasive and minimally invasive techniques, providing an opportunity for
 screening and surveillance of at-risk populations.

 Knowledge of the etiology of pancreatic cancer is incomplete. Approximately 10% of pancreatic
 ductal adenocarcinoma (PDAC) has a hereditary component, and screening this population has
 the potential to have an impact on disease mortality. Certain patient populations, such as
 those with hereditary pancreatitis, Peutz-Jeghers syndrome, familial atypical multiple mole
 melanoma (FAMMM syndrome), Lynch syndrome, and the breast ovarian cancer syndrome (BRCA1 and
 BRCA2 mutations) are at the highest risk of PDAC. BRCA2 mutations are the most commonly
 identified germline mutations in families with PDAC. Even a family history of PDAC without
 the above described syndromes has been shown to increase risk, suggesting a unique familial
 pancreatic cancer syndrome which may be related to the partner and localizer of BRCA2 (PALB2)
 gene or other PDAC susceptibility genes. Environmental risk factors, such as cigarette
 smoking, diabetes, obesity and dietary risk factors have been implicated in the development
 of PDAC.

 A sequential model of acquisition of somatic mutations via a Pancreatic Intraepithelial
 Neoplasia (PanIN) has been proposed for the development of PDAC and subsequent metastases.
 However, others have proposed that the metastatic process may be initiated earlier in the
 disease process during the pre-malignant cyst or PanIN phase. This may in part account for
 the fact that the overwhelming majority of patients diagnosed with PDAC are diagnosed when
 the lesion is already metastatic.

 Several groups have instituted PDAC screening for individuals at high-risk of PDAC. These
 groups have demonstrated the feasibility of detection of PDAC and pre-malignant lesions in
 certain high-risk individuals. Given the large gaps in knowledge, recruitment of patients
 with preneoplastic pancreatic diseases to registries is essential in the development of
 effective PDAC screening and prevention programs.

 As an increasing number of patients undergo cross-sectional imaging with the abdomen with cat
 scan (CT) and magnetic resonance imaging (MRI), an increasing number of patients are found to
 have pancreatic disease and pancreatic cysts. While there is an increased risk of pancreatic
 cancer with these lesions, the studies to date are small and retrospective.
Inclusion Criteria:

 -  ≥ 2 close family members (at least 1 first degree relative) affected with Pancreatic
 cancer

 -  Any of (BRCA1, BRCA2, PALB2, ATM) mutations + 1 family member with Pancreatic Cancer

 -  mFAMMM (p16,CDKN2A mutations) + 1 family member with Pancreatic cancer

 -  Known mutation carrier for STK11 (Peutz Jeghers Syndrome)

 -  Lynch syndrome (HNPCC) + 1 family PDAC

 -  Known mutation carrier for Hereditary pancreatitis

 -  Individuals with a history of pancreatic cyst(s) (IPMN's) that measure ≥ 1 cm

 Exclusion Criteria:

 -  Patients who do not speak English or Spanish

 -  Refusal by patient

 -  Individuals under the age of 18 years