Effect of Sildenafil for Sustained PAH After MV Surgery (SUPERIOR Trial)
Effect of Sildenafil for Sustained PAH After MV Surgery (SUPERIOR Trial)
The purpose of this study is to determine whether Sildenafil is effective in the treatment of
 sustained pulmonary artery hypertension after corrected mitral valve disease.
Inclusion Criteria:

 -  New York Heart Association Functional class (NYHA Fc) ≥ 2 dyspnea which was sustained
 till one year after the previous mitral valve surgery (repair or replacement)

 -  TR Vmax ≥ 3.5m/s by echocardiography

 -  Normal left ventricle ejection fraction (EF ≥ 50%)

 -  Pulmonary vascular resistance ≥ 3 Wood Unit or diastolic pressure gradient ≥ 7mmHg by
 cardiac catheterization

 Exclusion Criteria:

 -  Other valve disease more than moderate degree (ex. aortic stenosis, aortic
 regurgitation)

 -  Liver cirrhosis

 -  Chronic renal failure with serum creatinine ≥ 1.7mg/dL

 -  Lung disease (ex. chronic obstructive pulmonary disease, Asthma)

 -  Thyroid dysfunction

 -  Other causes which can lead to pulmonary hypertension