Correlation Between Laboratory Markers and Origin of New Brain Ischemic Lesions After Carotid Stenting
Correlation Between Laboratory Markers and Origin of New Brain Ischemic Lesions After Carotid Stenting
New brain ischemic lesions are detected in about 50% of patients undergoing carotid artery
 stenting (CAS). The aim was to assess correlation between selected laboratory markers and
 occurrence of new brain infarctions after CAS.
Methods: All consecutive patients 1) with internal carotid artery stenosis >70%, 2) indicated
 to CAS, 3) with signed informed consent were enrolled to the prospective study during 16
 months. All patients used dual antiplatelet therapy (acetylsalicylic acid [ASA] 100 mg +
 clopidogrel 75 mg per day) at least 7 days before CAS. Neurological examination and brain
 magnetic resonance imaging (MRI) were performed before and 24 hours after CAS in all
 patients. Venous blood samples were collected within 24 hours before CAS in all patients:
 hematology + reticulocytes, coagulation markers (PT, APTT, INR, Fbg, Clauss), vWF antigen,
 PAI-1 activity, PAI-1 polymorphism 4G/g, Multiplate (ASA and clopidogrel resistance test).
 Blood samples for the assessment of anti Xa activity were collected during CAS. T-test was
 used for statistical evaluation.
Inclusion Criteria:

 patients

 1. With internal carotid artery stenosis >70%

 2. Indicated to CAS

 3. With signed informed consent. Able to use (acetylsalicylic acid [ASA] 100 mg +
 clopidogrel 75 mg per day) at least 7 days before CAS

 Exclusion Criteria:

 -  Contraindication for magnetic resonance imaging