Recurrence in High-grade Lesions After Conization
Recurrence in High-grade Lesions After Conization
Objectives: To identify factors associated with disease recurrence in patients with
 high-grade cervical intra-epithelial neoplasia (CIN) undergoing large loop excision of the
 transformation zone (LLETZ).

 Study Design: A case-control study that included 103 patients. Patients were included in the
 study if they had a history of surgery for conization by LLETZ for the histopathological
 diagnosis of cervical intraepithelial neoplasia grades II and III (CIN II and CIN III).
 Follow-up exams were conducted every six months with Pap smear collection and colposcopic
 examination with biopsy, when necessary, for a minimum period of twelve months. Cure was
 defined as a normal follow-up examination within 24 months. During follow-up, relapse
 occurred when cytology and/or biopsy results showed that CIN had returned after 12 months, at
 which time a new cervical conization by LLETZ was performed.
Inclusion Criteria:

 1. history of surgery for conization

 Exclusion Criteria:

 1. under 18 years of age,

 2. immunosuppressed,

 3. Patient with a histopathological diagnosis of low-grade intraepithelial neoplasia

 4. Patient with invasion, or surgical margins obtained by LLETZ that were unable to be
 evaluated.