GADGET-PD Genetic and Digital Diagnosis of Essential Tremor and Parkinson's Disease Trial
GADGET-PD Genetic and Digital Diagnosis of Essential Tremor and Parkinson's Disease Trial
The proposed study will capitalize on the early predictive information stored in an
 individual's genetic risk for Parkinson Disease (PD) in combination with the subtle features
 of tremors that can be extracted from movement data gathered by modern compact accelerometers
 in order to determine if accurate discrimination of essential tremor (ET) from PD can be
 achieved. Both of these technologies have a proven but somewhat limited ability to inform
 diagnosis of PD or differentiation of PD from ET - especially at early stages of the disease.
 The investigators hypothesize that a combination of prior genetic risk and current disease
 symptomology can synergize for accurate and early discrimination of PD from ET and ultimately
 inform a cost effective approach to movement disorder diagnosis.

 In this study, the investigators will collect blood from individuals with confirmed
 late-onset diagnosis of PD and ET. Gold standard diagnosis status will be determined via the
 Unified Parkinson's Disease Rating Scale (UPDRS) - the accepted clinical gold standard for
 Parkinson's Disease diagnosis. DNA will be extracted from blood samples to characterize the
 genetic risk of individuals for PD via proven genetic risk models. In addition, participants
 will wear a wristwatch-like accelerometer device that will track their movements (tremors) at
 high temporal resolution and transmit movement data via a smartphone. Cognitive distraction
 tasks will be administered via mobile phones while simultaneously collecting movement data.
 Predictive tremor features will be extracted from movement data via signal processing
 approaches - e.g. discrete wavelet transformation. A final predictive model combining
 movement tracking information and genetic information will be designed in attempt to
 distinguish PD from ET individuals.
Inclusion Criteria:

 -  Idiopathic Parkinson's Disease as defined by the UK brain bank criteria and history of
 resting tremor, or:

 -  Essential Tremor with history of resting tremor. Diagnosis made by a movement disorder
 specialist.

 -  Midstage in disease process for Parkinson's disease with history of resting tremor

 Exclusion Criteria:

 -  Dementia as defined by a mini-mental state examination cutoff score of 27

 -  Atypical Parkinsonism

 -  Akinesia/ rigidity Parkinson's Disease

 -  Movement Disorders - Stiff-Person syndrome, choreatic disease, dystonia, progressive
 supranuclear palsy

 -  Motor neuron disease - Multiple sclerosis, amyotrophic lateral sclerosis, motor
 neuritis, progressive bulbar palsy, progressive muscular atrophy, spinal muscular
 atrophy

 -  Significant neurological comorbidities:

 -  Stroke

 -  Brain cancer or brain metastases

 -  History of bone marrow transplant

 -  Cerebral palsy and spastic paraplegia