Treatment of Sleep Related Breathing Disorders in Patients With Pulmonary Hypertension
Treatment of Sleep Related Breathing Disorders in Patients With Pulmonary Hypertension
The purpose of this study is to study the differential short-term effect of nocturnal oxygen,
 acetazolamide tablets and nocturnal non-invasive positive pressure ventilation on symptoms,
 exercise capacity and nocturnal breathing disturbances in subjects with pulmonary
 hypertension and sleep related breathing disorders

 -  Trial with medicinal product
Inclusion criteria:

 -  percapillary pulmonary hypertension diagnosed by right heart catheterisation -- stable
 therapy and clinical condition for at least 4 weeks

 -  sleep disordered breathing with apnea/hypopnea index > 10 events/h and/or median
 nocturnal oxygen saturation <90%

 Exclusion criteria:

 -  Pregnancy

 -  severe daytime hypoxemia (PaO2 < 7.2 kPA)

 -  patients with predominantly obstructive sleep apnea.