Additive Anti-inflammatory Action for Aortopathy & Arteriopathy (5A Plan)
Additive Anti-inflammatory Action for Aortopathy & Arteriopathy (5A Plan)
Acute Aortic Syndrome (AAS) is a common feature of acute aortic wall events, including aortic
 dissection, intramural hematoma, aortic ulceration and aortic trauma, and occurs in up to 35
 cases per 100,000 cases per year between the ages of 65 and 75 years. Increased levels of the
 inflammatory biomarker high-sensitivity C-reactive protein predict cardiovascular events.
 Since statins lower levels of high-sensitivity C-reactive protein as well as cholesterol, the
 authors hypothesized that people with acute aortic syndrome but without hyperlipidemia might
 benefit from statin treatment.
Inclusion Criteria:

 -  (1) Patients with aortic dissection/ulceration/intermural hematoma who underwent
 aortic arch replacement or endoluminal isolation or hybrid therapy;

 -  (2) Paitents without clinically significant hyperlipidemia but with cardiovascular
 disease risk factors (such as male ≥45 years old, female ≥55 years old, hypertension,
 diabetes, chronic kidney disease, obesity, low HDL cholesterol, smoking, alcohol
 consumption, family history of early onset ischemic cardiovascular disease) and no
 previous use of statins;

 -  (3) Patients are between 18 and 85 years old, male or female;

 -  (4) Agree to participate in the study and sign the informed consent.

 Exclusion Criteria:

 -  (1) Patients with allergy to statins;

 -  (2) patients with active liver disease;

 -  (3) patients with myopathy;

 -  (4) Lactating women and pregnant women;

 -  (5) Patients with mental diseases, drug and alcohol dependence;

 -  (6) Refuse to participate in the study or sign the informed consent.