Magnetic Resonance Thermal Image Guided Laser Interstitial Thermal Therapy in Treating Patients With Breast Cancer
Magnetic Resonance Thermal Image Guided Laser Interstitial Thermal Therapy in Treating Patients With Breast Cancer
This pilot clinical trial studies magnetic resonance thermal image guided laser interstitial
 thermal therapy in treating patients with breast cancer. Magnetic resonance thermal image
 guided laser interstitial thermal therapy may be able to kill tumor cells by heating up the
 tumor cells without affecting the surrounding tissue
PRIMARY OBJECTIVES:

 I. To evaluate the procedural success rate of using the Visualase magnetic resonance
 (MR)-guided laser system to target, access, thermally monitor, and focally ablate MR-visible
 breast cancer lesions.

 2. To obtain preliminary data on ablative success using pathologic assessment for specimen
 excised subsequent to the ablation.

 OUTLINE:

 Patients undergo MR-thermal image guided laser interstitial thermal therapy (LITT) over 1
 hour.

 After completion of study treatment, patients are followed up at 3-7 days.
Inclusion Criteria:

 -  Postmenopausal state

 -  Histological diagnosis of breast invasive ductal carcinoma with receptor profiles
 obtained

 -  MRI visible breast lesion

 -  Unifocal cancer, less than 1.5 cm in maximum diameter (clinical stage T1), with no
 evidence of extensive in situ cancer surrounding the main tumor; the eligibility will
 be determined by the MR imaging appearance of the tumor; if the tumor (proven invasive
 ductal carcinoma) is a unifocal mass without additional enhancement, it will be judged
 eligible; however, if the tumor is associated with additional enhancement and/or a
 satellite focus, it will not judged ineligible, as these are signs of additional in
 situ or invasive cancer

 -  Clinical stage N0 (no metastatic axillary lymph node on physical examination or
 imaging work-up)

 -  Ability to give informed consent

 Exclusion Criteria:

 -  Previous surgery or radiation for the ipsilateral breast cancer

 -  Presence of any condition (e.g., metal implant, shrapnel) not compatible with MRI

 -  Tumor located less than 1 cm from the skin or the pectoralis muscle