Scandinavian Urethroplasty Study
Scandinavian Urethroplasty Study
A multicentre, prospective, randomized study comparing bulbar urethroplasty with excision and
 primary anastomosis or with an onlay grafting procedure using buccal mucosa.
The study is a prospective, randomized study to compare two common techniques of
 urethroplasty used to treat bulbar urethral strictures. One technique is excision of the
 stricture and end-to-end anastomosis of the urethra. The other technique is an onlay grafting
 procedure with buccal mucosa where the corpus spongiosum is not divided. The study is
 designed to compare complications of sexual and penile function, and is not powered to
 compare the success rates of the two techniques. The primary endpoint will be degree of
 erectile dysfunction and penile complications. The secondary endpoint will be restricturing
 leading to reoperation, and other complications.
Inclusion Criteria:

 Patient with bulbar urethral stricture, length estimated by urethrography or endoscopy ≤ 2
 cm

 Patient is able and willing to sign informed consent

 Patient is able and willing to complete all study requirements

 Exclusion Criteria:

 Previous open urethroplasty

 Previous hypospadia surgery

 Previous surgery for congenital curvature or Mb Peyronie

 Previous pelvic irradiation therapy

 Known grave psychiatric disorder

 Haemophilia or other clotting disorders that cause bleeding diathesis

 Use of medication to increase erectile function, such as PDE5-inhibitors and intracavernous
 injections, during the study

 Any condition or situation, which, in the investigator's opinion, puts the patient at
 significant risk, could confound the study results, or may interfere significantly with the
 patient's participation in the study