Antibiotic Concentrations Among Critically Ill Patients
Antibiotic Concentrations Among Critically Ill Patients
The primary objective of the DALI study is to compare antibiotic concentrations in patient
 blood samples with bacteriological objectives associated with maximum bactericidal activity.
 The antibiotics studied are certain lactams and glycopeptides.
Inclusion Criteria:

 -  The patient (or his/her "trusted representative") must have given his/her informed and
 signed consent

 -  Antibiotic treatment is administered with beta-lactams or glycopeptides administered
 continuously or intermittently (Can be of the following: Amoxicillin-clavulanic acid,
 ampicillin, piperacillin-tazobactam, penicillin G, flucloxacillin, dicloxacillin,
 cloxacillin, cefazolin, ceftazidime, ceftriaxone, cefepime, meropenem, imipenem,
 doripenem, ertapenem; Vancomycin, teicoplanin).

 -  A vein or artery catheter is established to facilitate blood sampling (arterial
 catheter is preferred)

 Exclusion Criteria:

 -  None of the above-mentioned antibiotics are administered

 -  Impossible to establish venous or arterial catheter

 -  Consent not given

 -  Patient is pregnant, parturient or breastfeeding

 -  The patient is under tutorship or curatorship

 -  The patient is participating in another study