Prophylactic Corticosteroid to Prevent COVID-19 Cytokine Storm
Prophylactic Corticosteroid to Prevent COVID-19 Cytokine Storm
This is a Phase II pilot exploratory study designed to investigate if prophylactic treatment
 with short term steroids administered to high risk Covid-19 patient might prevent cytokine
 storm and progression to respiratory failure. High risk is defined based on serologic markers
 of inflammation that include abnormalities of Interleukin 6 (IL-6), Ferritin , D-dimer,
 Lactate Dehydrogenase (LDH), as well as lymphopenia and impaired O2 saturation prior to or on
 the 7th day of first symptom of Covid-19.
To decrease the rate of progression to hypoxemic respiratory failure in high risk patients
 with Covid-19, treated with prophylactic steroids during the first phase of the disease.
Inclusion Criteria:

 -  All patients diagnosed with Covid-19 will be registered on the study regardless pf
 their severity, but only those who meet high risk criteria will be treated with
 steroids. Those who don't meet the criteria will only be registered with no need to
 collect further data except baseline labs and CT Chest. They should sign the consent
 form and the data manager can collect the rest of the information.

 -  Patients older than 18 years diagnosed with Covid-19 by Polymerase Chain Reaction
 (PCR) or by rapid serological test will be eligible. Cases who are Immunoglobulin G
 (IgG) positive but Immunoglobulin M (IgM) negative, will not be considered eligible
 unless they are positive for molecular PCR test. Eligible patients will be registered
 on study on or before 7 days from first onset of symptoms.

 Exclusion Criteria:

 -  Any patient with life expectancy < 1 month

 -  Any patient who is oxygen dependent

 -  Any patient with long standing history of severe Chronic Obstructive Pulmonary Disease
 (COPD)

 -  Any patient who is chronically oxygen dependent because of previous existing lung
 disease

 -  Anyone with severely uncontrolled diabetes despite adequate management

 -  Anyone with active serious bacterial infection such as septicemia or pneumonia

 -  Anyone receiving Tocilizumab (anti IL-6 therapy) or plasma therapy

 -  Any patient already receiving steroids from another pre-existing illness