Laboratory Study in Predicting Tumor Response to Chemotherapy in Patients With Ovarian Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer
Laboratory Study in Predicting Tumor Response to Chemotherapy in Patients With Ovarian Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer
RATIONALE: Collecting samples of tissue from patients with cancer to study in the laboratory
 may help doctors predict how well patients will respond to treatment with certain
 chemotherapy drugs and plan the best treatment.

 PURPOSE: This laboratory study is looking at tumor tissue samples to predict response to
 chemotherapy in patients with ovarian cancer, fallopian tube cancer, or primary peritoneal
 cancer.
OBJECTIVES:

 -  Evaluate the ability of the microculture kinetic (MiCK) assay to predict the outcome of
 patients with ovarian, fallopian tube, or primary peritoneal adenocarcinoma treated with
 first-line chemotherapy.

 -  Evaluate the ability of the MiCK assay to guide chemotherapy in a third-line, refractory
 treatment setting (exclusive of anti-vascular endothelial growth factor) in these
 patients.

 OUTLINE: Patients are stratified according to prior chemotherapy (no [stratum I] vs yes
 [stratum II]).

 Tumor tissue and/or effusion specimens are collected at baseline. Specimens are examined by
 the microculture kinetic (MiCK) assay and immunocytochemical or flow cytometry assay.

 MiCK assay results do not influence treatment for stratum I patients. Stratum II patients may
 receive treatment based on MiCK assay results for tumor sensitivity to specific chemotherapy
 drugs.

 PROJECTED ACCRUAL: A total of 60 patients will be accrued for this study.
DISEASE CHARACTERISTICS:

 -  Pathologically confirmed adenocarcinoma of 1 of the following types:

 -  Ovarian

 -  Primary peritoneal

 -  Fallopian tube

 -  Must meet 1 of the following criteria:

 -  De novo malignancy with no prior chemotherapy

 -  Advanced refractory malignancy with ≤ 2 standard chemotherapy treatment protocols

 -  Tumor must be accessible for biopsy or drainage of effusions

 -  Chemotherapy is considered a treatment option

 -  No symptomatic or uncontrolled parenchymal brain metastases

 -  No meningeal metastasis

 PATIENT CHARACTERISTICS:

 -  Not pregnant

 -  Negative pregnancy test

 -  Fertile patients must agree to use effective contraception

 PRIOR CONCURRENT THERAPY:

 -  See Disease Characteristics