Effect of Sodium Lauryl Sulfate on Recurrent Aphthous Stomatitis
Effect of Sodium Lauryl Sulfate on Recurrent Aphthous Stomatitis
Sodium lauryl sulfate (SLS) is an anionic detergent that has been used as the major or sole
 surfactant in most dentifrices. But it is known to local irritating factor to oral mucosa and
 skin and results in many side effects. This study was to compare the effects of SLS-free
 dentifrice and SLS-containing dentifrice in patients with recurrent aphthous stomatitis
 (RAS).
Inclusion Criteria:

 -  The volunteers had a history of regularly recurring oral ulcerations of at least 6
 months duration, with more than one episode per month

 Exclusion Criteria:

 -  already using an SLS-free dentifrice

 -  taking medications affecting oral ulcers (e.g., corticosteroids)

 -  having chronic oral mucosal disease (ex, lichen planus, pemphigus vulgaris,
 pemphigoid, and etc.)

 -  having allergies to food or medications

 -  being pregnant