Challenge Test for Acetylsalicylic Acid Hypersensitivity
Challenge Test for Acetylsalicylic Acid Hypersensitivity
The investigators want to find new challenge test for Acetylsalicylic hypersensitivity /
 Aspirin hypersensitivity. The investigators suggest that this new test will be as efficient
 as the already established protocols in terms of sensitivity and specificity.
Hypersensitivity to Acetylsalicylic Acid or Aspirin (and other NSAIDS) is a condition that
 affects up to 2,5% of the population. Most cases are seen in a complex of such
 hypersensitivity with chronic eosinophilic rhinosinusitis with nasal polyposis and asthma.
 Despite research in finding a reliable in-vitro-test for the condition, challenge tests are
 still considered gold standard. So far oral, nasal, inhalation and intravenous routes of
 administration has been described in literature.
Inclusion Criteria:

 -  Persons between 18 and 60 years of age

 -  Suspected Acetylsalicylic Acid Hypersensitivity

 Exclusion Criteria:

 -  History on anaphylactic shock after NSAIDS intake

 -  History on gastric ulcer after NSAIDS intake

 -  Patients previously gone through testing or desensitisation for Aspirin
 hypersensitivity

 -  Clinical unstable asthma or baseline FEV1<70%

 -  Severe disease of the heart, digestive tract, liver or kidney

 -  Severe chronic urticaria

 -  Present conjunctivitis

 -  Pregnancy