Genetic Analysis of Human Hypertensive End Stage Renal Disease (H-ESRD)
Genetic Analysis of Human Hypertensive End Stage Renal Disease (H-ESRD)
To identify genes causing hypertensive end-stage renal disease (H-ESRD) in high risk
 African-American populations
BACKGROUND:

 Although hypertension is a predisposing factor for end stage renal disease, the underlying
 hypothesis of this study was that in select African-American families genetic factors
 predisposed them to develop ESRD in the face of hypertension. An inherited basis for H-ESRD
 was supported by familial clustering of H-ESRD among African Americans that could not be
 explained by socioeconomic status, access to medical care, and the prevalence of diabetes and
 hypertension.

 DESIGN NARRATIVE:

 DNA samples were collected, identified, and clinically characterized from African-American
 sib-pairs (and other family members with hypertensive end-stage renal disease). This aspect
 of the study was based on the fact that Dr. Freedman, the principal investigator, had already
 developed a unique "family history of end-stage renal disease" database independently funded
 by the End-Stage Renal Disease Network Six. This registry served as a very large and unique
 collection of African-American end-stage renal disease patients. He began with a candidate
 gene approach for linkage to hypertensive end-stage renal disease in his patient samples
 using a variety of growth factor genes, genes involved in sodium transport and vascular tone,
 as well as human homologues of rodent genes that had, or were to be identified in the future
 as contributing to ESRD in that organism. If this initial first pass of candidate genes
 failed to demonstrate linkage to hypertensive end-stage renal disease, a systematic
 genome-wide scan was to be performed with available simple sequence length polymorphisms
 (SSLP) and other polymorphic markers. Hypertensive end-stage renal disease is a condition of
 enormous clinical and economic importance and identification of associated or causative
 renal-failure genes would form a genetic basis for the detection of high-risk individuals and
 assist in development of intervention and treatment strategies to prevent this condition.

 The study completion date listed in this record was obtained from the "End Date" entered in
 the Protocol Registration and Results System (PRS) record.
No eligibility criteria