Identification of Sentinel Lymph Nodes With Methylene Blue and Isotope
Identification of Sentinel Lymph Nodes With Methylene Blue and Isotope
The aim of this study is to evaluate the performance of a double labelling method using
 isotope and methylene blue dye injection to localize precisely Sentinel Lymph Node (SLN) in a
 series of 100 patients with infiltrative breast cancer justifying SLN excision. Method and
 patients: SLN excision will be performed on 100 patients treated for infiltrative breast
 cancer. After preoperative methylene blue dye injection and lymphoscintigraphy, individual
 localization of the radioactive and stained nodes will be performed. After the surgery, SLN
 will be submitted to serial analysis and immunohistochemistry. A comparison of the two
 methods and an economical evaluation of the complete procedure will be performed.
Inclusion Criteria:

 -  patients with infiltrative breast cancer (diagnosed pre-operatively by core biopsy)

 -  approval and informed consent

 Exclusion Criteria:

 -  chemotherapy

 -  locoregional radiotherapy

 -  prevalent axillary lymph node