Characterization of Novel Lipoprotein Properties Associated With an Increased Risk to Develop Atherosclerosis
Characterization of Novel Lipoprotein Properties Associated With an Increased Risk to Develop Atherosclerosis
Objectives of Medical Research:

 Separation of LDL and HDL from blood samples of patients with high LDL and / or low HDL who
 have developed atherosclerotic disease with similar patients who have no evidence of
 atherosclerosis.

 Lipidomics and proteomics will examine whether there is a difference in lipid and protein
 composition and lipoprotein composition. If there are any changes in expression level or the
 composition of proteins or metabolites that make up lipoproteins, we will try to figure out
 the mechanism responsible for these changes and their role in the metabolic process. we will
 seek therapeutic measures through which these mechanisms can be inhibited and thus inhibit
 the development of sclerosis or even retraction.
Participants:

 Participants who are found suitable during their visit to the Lipid Institute Clinic or
 during hospitalization at the Sheba Medical Center will receive an explanation of the study,
 will be asked to sign a consent form.

 A medical history will be taken, the participant will be asked to fill out a nutrition
 questionnaire (FFQ) and a 5 cc blood sample will be taken from each patient
Inclusion Criteria:

 -  Healthy participants with LDL levels less than 130 mg / dl without evidence of
 atherosclerosis or wall thickening of the carotid artery according to an ultrasound
 imaging of the carotid artery at the Lipid Institute and unknown for atherosclerosis
 or cardiovascular disease in the background.

 -  Participants with LDL levels above 160 mg / dl, with no evidence of atherosclerosis or
 wall thickening of the carotid artery according to an ultrasound - IMT of the carotid
 arteries performed at the Lipid Institute and unknown for atherosclerosis or
 cardiovascular disease in the background.

 -  Participants with LDL levels above 160 mg / dl, where evidence of atherosclerosis or
 wall thickening of the arteries can be found by ultrasound imaging of the carotid
 artery that is performed at the Lipid Institute or known for atherosclerosis or
 cardiovascular disease in the background.

 Exclusion Criteria:

 -  Patients with triglyceride values above 300 mg%, HDL lower than 30 mg%, APOB greater
 than 150 mg% or LPa higher than 70 mg% will not be included in the study