Effect of Tonsillectomy on Longterm Renal Outcome of IgA Nephropathy
Effect of Tonsillectomy on Longterm Renal Outcome of IgA Nephropathy
The effect of tonsillectomy therapy on IgA nephropathy is still controversial.Few
 prospective,randomized investigations have examined how tonsillectomy affects the shortterm
 and longterm renal outcome of IgA nephropathy.This is A prospective,randomized ,controlled
 study to explore the longterm effect of tonsillectomy for patients with IgA nephropathy.
Inclusion Criteria:

 -  Willingness to sign an informed consent

 -  Age:18~45 years, regardless of gender

 -  Clinical evaluation and renal biopsy diagnostic for immunoglobulin A nephropathy
 (IgAN), excluded secondary IgAN. Renal histological criteria should be defined by
 Lee's glomerular grading system.

 -  Any one of three Tonsilar conditions defined by Otorhinolaryngologist : 1,recurrent
 acute tonsillitis accompanied with gross hematuria or urinary findings
 abnormality；2,recurrent acute tonsillitis without gross hematuria，but tonsil
 provocation test was positive；3, No history of acute tonsillitis,body examination
 found hypertrophy or atrophy tonsils ,crypt pus of tonsils ,or scars on the tonsil
 surface ,and positive tonsil provocation test.

 -  Estimated glomerular filtration rate (eGFR) ≥ 30 mL/min/1.73 m2

 Exclusion Criteria:

 -  Inability or unwillingness to sign the informed consent

 -  Inability or unwillingness to meet the scheme demands raised by the investigators

 -  Rapidly progressive nephritic syndrome and acute renal failure, 24-hour urine
 protein≥3.5g,including rapidly progressive IgAN (IgAN with rapid decline in renal
 function characterized histologically by necrotizing vasculitis and crescent
 formation≥30%) necessitating the use of other immunosuppressive agents.

 -  Secondary IgAN such as systemic lupus erythematosus, Henoch-Schonlein purpuric
 nephritis and hepatitis B -associated nephritis

 -  est GFR < 30 mL/min/1.73m2

 -  Malignant hypertension that is difficult to be controlled by oral drugs

 -  Cirrhosis, chronic active liver disease.

 -  History of significant gastrointestinal disorders (e.g. severe chronic diarrhea or
 active peptic ulcer disease.)

 -  Any Active systemic infection or history of serious infection within one month of
 entry or known infection with HIV, hepatitis B, or hepatitis C.

 -  Other major organ system disease (e.g. serious cardiovascular diseases including
 congestive heart failure , chronic obstructive pulmonary disease, asthma requiring
 oral steroid treatment or central nervous system diseases)

 -  Malignant tumors (except fully cured basal cell carcinoma)

 -  Current or recent (within 30 days) exposure to any other investigation

 -  Current exposure to mycophenolic mofetil (MMF),azathioprine or corticosteroids. In
 case of current treatment with oral steroid ,entry is permitted after corticosteroids
 dosage below 0.4mg/kg per day.

 -  Pregnancy or breast feeding at the time of entry or unwillingness to comply with
 measures for contraception

 -  Tonsillectomy had been done when IgAN diagnosis or known contraindication to
 tonsillectomy(such as neutropenia，bleeding tendency，or anatomic abnormalities）