Evaluation of Probiotics and the Development of Clostridium Difficile Associated Diarrhea in Patients Receiving Antibiotics
Evaluation of Probiotics and the Development of Clostridium Difficile Associated Diarrhea in Patients Receiving Antibiotics
We have designed this study to measure the effect of normal flora supplementation, using
 available probiotics, on the incidence of Clostridium difficile-associated diarrhea

 in a population of general inpatients who are receiving antibiotics.
General medical-surgical patients in a community hospital who are receiving antibiotics, and
 who agree to participate, will be given one of two different probiotics, or placebo. Data
 will be gathered during their hospitalization, and at one and three months following hospital
 discharge. We expect to see a lower incidence of Clostridium difficile-associated diarrhea in
 the probiotic groups when compared to the placebo group. We will also be looking for
 differences between the effects of the two probiotics, which differ in strain types and
 number of colony forming units per dose.
Inclusion Criteria: Any hospitalized patient who is age 19 or older and receiving
 antibiotics.

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 Exclusion Criteria:

 -  Feeding tube in place

 -  Pregnancy

 -  Milk or soy allergy

 -  Sensitivity to lactose

 -  Immunocompromised defined as:

 1. Absolute neutrophil count (ANC) ≤ 500 cells/mm3

 2. HIV

 3. Cancer patient receiving chemotherapy or radiation therapy

 4. Immune deficiency

 5. Post organ transplant

 Participants will be withdrawn from the study if they develop any of the exclusion criteria
 during the hospitalization.

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