Articular Cartilage Resurfacing With Mesenchymal Stem Cells In Osteoarthritis Of Knee Joint
Articular Cartilage Resurfacing With Mesenchymal Stem Cells In Osteoarthritis Of Knee Joint
Knee osteoarthritis is the most common form of arthritis. Treatments involve high costs in
 terms of social and economic, are palliative and do not contemplate healing by regenerative
 therapy. It has been shown recently, that mesenchymal stem cells (MSC) can be expanded in
 vitro and may regenerate several damaged or injured tissues. In addition its has demonstrated
 that MSC are able to modulate immune responses and to control inflammation through its action
 on T lymphocytes. Preliminary studies in animal models, including one carried out in an
 equine by the investigators research group, confirms feasibility, safety and efficacy
 evidence proposed treatment protocol.This study is designed to evaluate therapeutic potential
 and safety of mesenchymal stem cells in improvement of osteoarthritis clinical
 manifestations.This study is designed to evaluate therapeutic potential and safety of
 mesenchymal stem cells in improvement of osteoarthritis clinical manifestations.
Mesenchymal stem cells are pluripotent cells that can be obtained from various tissues .They
 have shown capabilities to differentiate into bone,cartilage,muscle,and adipose tissue,
 representing a new clinical strategy in regenerative medicine.An increasing number of reports
 have demonstrated effectiveness of percutaneous intra-articular infusion of MSCs in arthritic
 disease. In this study we perform a single intra articular injection of cultured mesenchymal
 stem cells in patients suffering from osteoarthritis, with the aim to assess its clinical
 safety and efficacy.Patients are assessed for response with MRI, X-Ray examination, WOMAC
 osteoarthritis index,VAS, and SF36 2,4,8 weeks and 6, and 12 months post infusion.
Inclusion Criteria:

 -  Female patients not pregnant or lactating.

 -  Patients with a history of corticosteroids or on active therapy, will only be eligible
 for enrollment if corticosteroid use is suspended for 1 month prior cell therapy

 -  Marcaine 0.75% و Lidocaine 4% test performed to be assure the exact location of the
 pain is related to the knee.

 -  Diagnosis must be based on magnetic resonance imaging.

 -  Both genders

 -  Age:18-65 years

 Exclusion Criteria:

 -  Diagnosis of cancer,DM,CNS disorder,thyroid disease or respiratory disease.

 -  Known allergic reaction to components of study treatment and/or study injection
 procedure

 -  Patients infected with hepatitis B,C or HIV.