PATAKESS Protocol : Clinical and Biological Analysis of Exocrine Pancreatic Tumors
PATAKESS Protocol : Clinical and Biological Analysis of Exocrine Pancreatic Tumors
PATAKESS is a monocentric non interventional cohort study (prospective (alive patients) and
 retrospective (dead patients with biological material from surgery and/or biopsies already
 collected)).

 PATAKESS consists of clinical and biological analyses of exocrine pancreatic tumors. Data are
 derived from tumor samples taken for routine health care purposes in patients managed at
 Centre Léon Bérard (Lyon-France) since January 2010. The main objective is to determine
 correlation between biological and clinical characterizations of patients suffering from
 exocrine pancreatic tumor.
Pancreatic adenocarcinoma cancer is an aggressive cancer which represents 95% of pancreatic
 cancer. Pancreatic adenocarcinoma cancer is one of the deadliest cancers (5th cause of death
 per cancer) ; it has a very poor prognosis: 5-year survival (regardless of all stades at
 diagnosis). Pancreatic adenocarcinoma cancer is characterized by early metastasis. Therefore,
 development of efficient systemic therapeutics is one of the keys to improving prognosis.
 Newly developed immune check-point inhibitors seem to have limited efficacy in pancreatic
 adenocarcinoma except for MSI-H (Microsatellite instability-high) or dMMR (mismatch repair
 deficient)/MSI-H tumors.

 However, recent data suggest that immune surveillance could control metastatic dissemination
 of pancreatic adenocarcinoma cancer. Several studies showed strong interactions between
 pancreatic tumor cells and tumor stroma in metastatic dissemination and in resistance to
 conventional therapeutics. Many data about pancreatic primitive tumors from murine animals
 models are available ; however few data on tumor stroma and its interactions with tumor cells
 of metastasis from adenocarcinoma pancreas are available. Few data on correlation between
 molecular alterations types (mutations, deletions, amplifications) in pancreatic
 adenocarcinoma cells and tumor stroma characteristics (primitive and metastatic stroma (cells
 composition, immune infiltration)) are also available.

 In PATAKESS study, clinical and biological data are derived from tumor samples taken for
 routine health care purposes in patients managed at Centre Léon Bérard (Lyon-France) since
 January 2010.
Inclusion Criteria:

 -  Male or female patient 18 age or older

 -  Patient operated on for exocrine pancreatic adenocarcinoma at Centre Léon Bérard since
 01/01/2010.

 -  Histological diagnosis of exocrine pancreatic adenocarcinoma confirmed with surgery
 specimen.

 Exclusion Criteria:

 -  Not applicable