Cerebral Artery Stenosis, Coronary Artery Disease and Arrhythmia
Cerebral Artery Stenosis, Coronary Artery Disease and Arrhythmia
There are many reports about the association of coronary artery disease (CAD) and cerebral
 artery stenosis (CAS), which had been proved to induce stroke and cognition decline after the
 revascularization including coronary bypass surgery (CABG) or percutaneous coronary
 intervention. Perfusion defect on nuclear brain scan is also noted to correlate with these
 neurological complications. On the other hand, the perioperative arrhythmia and following
 cerebral embolism was also attributed to be one factor inducing such neurological hazards.

 In the patients with coexistent CAD and CAS (1st group), and also the patients scheduled for
 CABG or percutaneous coronary intervention (PCI) (2nd group), we, the researchers at Far
 Eastern Memorial Hospital, attempted to integrate all the parameters mention above, including
 angiography of coronary and cerebral system, quantitative analysis of nuclear brain scan,
 biochemical profile, and signals of a new ambulatory device which could record the
 electrocardiograph (ECG) and electroencephalograph (EEG) simultaneously, in order to define
 the correlation between them. A chorological relation between EEG signals and ECG signals is
 our first target to be worked out. Thereafter, we hope to establish a regression model of all
 involved parameters according to the relation. Such a model, we believe, is essential not
 only to explain the post-CABG neurological complications, but to prevent them.

 Furthermore, for the undetermined ischemic stroke patients who had no obvious culprit artery
 or embolism source, the paroxysmal arrhythmia had long been regarded as the cause. Whether a
 paroxysmal atrial fibrillation, which had not been disclosed by routine ECG, could induce
 most of such a stroke is still not known. With this new ambulatory device which could record
 the electrocardiograph (ECG) and electroencephalograph (EEG) simultaneously, we want to
 answer the question.
Inclusion Criteria:

 -  Coronary artery stenosis >50% and either carotid or brain artery stenosis > 50%

 Exclusion Criteria:

 -  Creatinine > 2.0 mg/dL

 -  Co-morbidity

 -  ER

 -  A letter of authorization is not given