Temocillin Use in Complicated Urinary Tract Infections Due to Extended Spectrum Beta-Lactamases (ESBL)/AmpC Enterobacteriaceae
Temocillin Use in Complicated Urinary Tract Infections Due to Extended Spectrum Beta-Lactamases (ESBL)/AmpC Enterobacteriaceae
This study is aimed at demonstrating the efficacy of temocillin in the treatment of
 complicated Urinary Tract Infection (UTI) due to confirmed Extended Spectrum Beta-Lactamases
 (ESBL) producing or AmpC hyperproducing Enterobacteriaceae in the United Kingdom.
The spectrum of activity together with the route of excretion of temocillin makes it a good
 candidate for the treatment of urinary tract infections. Several studies have shown very good
 clinical and microbiological activity in uncomplicated and complicated cystitis and
 pyelonephritis in adults and in pyelonephritis in children older than 2 months. However there
 is no specific study performed on Urinary Tract Infections due to broad spectrum ß-lactamases
 producing strains.

 In this context, this study is aimed at demonstrating the efficacy of temocillin in the
 treatment of complicated Urinary Tract Infection due to confirmed Extended Spectrum
 Beta-Lactamases (ESBL) producing or AmpC hyperproducing Enterobacteriaceae in the United
 Kingdom. The investigators will also evaluate the tolerance of the drug by monitoring the
 adverse event and the incidence of eventual Clostridium difficile associated infection.
Inclusion Criteria:

 -  patients presenting a complicated urinary tract infection due to a confirmed Extended
 Spectrum Beta-Lactamases (ESBL) producing or AmpC hyperproducing Enterobacteriaceae
 susceptible to temocillin requiring parenteral antimicrobial therapy.

 -  community or hospital acquired infecting bacteria.

 -  signed informed consent

 Exclusion Criteria:

 -  patients infected with a strain resistant to temocillin

 -  patients having received an active antimicrobial therapy during the 48h before the
 beginning of temocillin treatment except temocillin

 -  patients presenting another site of infection than urinary (except onset of bacteremia
 from urinary tract origin) due to Gram negative bacteria

 -  patients needing concomitant antimicrobial therapy with the exception of
 benzylpenicillin

 -  uncomplicated cystitis

 -  complete obstruction of the urinary tract

 -  prostatitis

 -  peri-nephretic or intrarenal abscesses

 -  renal transplant

 -  children (up to 18 years old)

 -  pregnancy or lactation

 -  chronically dialyzed patients

 -  immunocompromising therapy or illness

 -  known allergy to penicillin