Single and Multiple Dose Safety, Tolerability, PK and Food Effect Study of HEC122505MsOH Tablets in Healthy Adult Subjects
Single and Multiple Dose Safety, Tolerability, PK and Food Effect Study of HEC122505MsOH Tablets in Healthy Adult Subjects
The Safety, Tolerability, Pharmacokinetic and Food Effect Study of HEC122505MsOH Tablets in
 Healthy Subjects
Inclusion Criteria:

 1. Subjects who are willing and are able to provide a written informed consent to
 participate in the study.

 2. Without Plann for pregnancy or pregnant within 3 months after enrollment throughout
 the trial.

 3. Subjects aged between 18 and 45 (both inclusive) years old.

 4. Healthy volunteers has a body weight ≥50 kg (for male) or ≥ 45kg (for female) and body
 mass index ≥18 and ≤28 kg/m2 at screening.

 5. Subjects, who are healthy, as having no clinically significant abnormalities in vital
 signs, physical examination, clinical laboratory test results, Chest X-ray and 12-lead
 electrocardiogram (ECG).

 Exclusion Criteria:

 1. Subjects with a positive serology for human immunodeficiency virus (HIV) antibodies,
 hepatitis B surface antigen (HBsAg), hepatitis C virus (HCV) antibodies and/or TP
 antibodies at screening.

 2. Patients with the following diseases of clinical significance, including but not
 limited to those with gastrointestinal, kidney, liver, nerve, blood, endocrine, tumor,
 lung, immune, mental, or cardiovascular and cerebrovascular diseases.

 3. nown allergic reactions or hypersensitivity to any excipient of the drug
 formulation(s)， anaphylaxis physique.

 4. Use of any prescription or non-prescription medications within 14 days prior to
 initial dosing，Use of any drugs that inhibit or induce liver metabolism within 28 days
 before the first dose, or use of any of the following drugs within 28 days before the
 first dose: monoamine oxidase inhibitors, opioids, serotonergic drugs, sympathetic
 nerves Drugs, breast cancer resistance protein substrates, dopaminergic antagonists,
 etc.

 5. Consume foods or beverages containing caffeine, xanthine, alcohol, and grapefruit
 within 48 hours prior to initial dosing.

 6. Positive results from urine drug screen test.

 7. History of alcoholism or drink regularly within 3 months prior to the study (defined
 as Alcohol consumption of > 21 units/week), or positive results from alcohol breath
 test.

 8. Regular smoking of more than 10 cigarettes per day within 3 months before
 administration of study drug, or inability to refrain from smoking during the course
 of the study.

 9. Donate blood or lose blood 400 mL or more within 1 month prior to initial dosing.

 10. Subjects who plan to receive or have had organ transplants.

 11. Females who are lactating/breastfeeding, or positive result from pregnancy test for
 women of child-bearing potential.

 12. Subjects who participated in another clinical trial within 3 months prior to initial
 dosing.

 13. Any other condition with in the opinion of the investigator would render the patient
 unsuitable for inclusion in the study.