Obesity and Clinical Presentation of Hyperandrogenism
Obesity and Clinical Presentation of Hyperandrogenism
Polycystic Ovarian Syndrome (PCOS) is the most common endocrine disorder in reproductive
 women. It is estimated that 5 to 10% of women of reproductive age have PCOS. One of the major
 diagnostic criteria of PCOS was chronic anovulation which lead to irregular menstruation,
 amenorrhea, and infertility; the other diagnostic criteria was hyperandrogenism which lead to
 hirsutism, acne and alopecia. Furthermore, PCOS is thought as a metabolic disorder, the
 long-term consequence of PCOS were diabetes mellitus and cardiovascular disease, which are
 potentially dangerous in women health. Early diagnosis and prevention is very important to
 the PCOS patients.

 Obesity is the most potential risk of threat to health of populations. There is a major
 impact of obesity on the PCOS related disorders. Insulin resistance and distribution of
 adipose tissue were thought to be the important risk factors of cardiovascular and metabolic
 syndrome. To treat PCOS patients properly,Wan-Fang hospital had established a specific
 medical team. The investigators recently published in "Fertility and Sterility" about the
 clinical presentation of androgen excess in Taiwanese women. Hirsutism is much less
 prevalence (30%) in Taiwanese PCOS women than that previous reported (65-80%) in theWestern
 women. It is important to know that some clinical presentation of PCOS might have ethic
 variance. Insulin resistance was reported as another candidate that might have ethic
 variance. The investigators had reported about 40% women in PCOS women were obese, it is
 similar with previous literature reported. Obesity is a major factor that could be controlled
 during the treatment of PCOS.Weight reduction is one of our methods in PCOS treatment. The
 progressive results for obese PCOS women would be facing the risks of diabetes and metabolic
 syndrome. The investigators thought like to evaluate the benefit of weight reduction program
 to the prognosis of obese women with PCOS.

 Furthermore, it is known that Endothelial progenitor cells (EPC) be an early marker of
 cardiovascular disease, the investigators would like to know the role of EPC to predict
 metabolic syndrome in women with PCOS. Wan-Fang hospital has a professional team in PCOS
 treatment and research which including gynecological endocrinologist, cardiologist, medical
 endocrinologist, specialist in weight reduction. This team had been working well for more
 that 4 years.

 The investigators hope that we can make a contribution to the study and treatment of PCOS in
 Taiwan.
Inclusion Criteria:

 -  Acne and/or hirsutism

 Exclusion Criteria:

 -  Male

 -  Menopause

 -  Tumor