Prophylactic Antibiotics on Urethral Catheter Withdrawal
Prophylactic Antibiotics on Urethral Catheter Withdrawal
Urinary-tract infection (UTI) is the most common type of hospital-acquired infection (30% of
 all). The purpose of this study is to determine whether antibiotic prophylaxis for urinary
 catheter removal is useful at preventing catheter-associated urinary-tract infection.
Urinary-tract infection (UTI) is the most common type of hospital-acquired infection (30% of
 all). The researchers undertake a double-blind, placebo-controlled trial to assess the
 efficacy of single-dose therapy of trimethoprim-sulfamethoxazole or ciprofloxacin, versus
 placebo therapy in selected groups of surgical patients who had bladder drainage scheduled to
 last longer than 3 days.
Inclusion Criteria:

 -  Urethral catheter in situ for at least 3 days (72h)

 Exclusion Criteria:

 -  Pregnancy

 -  Impaired renal or hepatic function (serum creatinine > 150 mmol/l, serum transaminases
 > 75 IU/l)

 -  Fever

 -  Symptomatic urinary tract infection

 -  Antibiotic use ≤ 48 hours before urinary catheter removal

 -  Allergy to trimethoprim-sulfamethoxazole or ciprofloxacin

 -  Urologic pathology