Medical Treatment of Endometriosis-Associated Pelvic Pain
Medical Treatment of Endometriosis-Associated Pelvic Pain
The Specific Aim of this project is to compare the efficacy and cost-effectiveness of
 continuous oral contraceptives versus leuprolide/norethindrone in the treatment of
 endometriosis-associated chronic pelvic pain. This comparison will be based on a randomized,
 double-blind, trial of women with chronic pelvic pain who have been diagnosed with
 endometriosis at the time of surgery within the last 3 years. We hypothesize that, over a
 12-month period of postoperative treatment, the efficacy of oral contraceptives is no worse
 than leuprolide/norethindrone, and that treatment with oral contraceptives is more
 cost-effective.
-  Background-Laparoscopic surgical treatment for endometriosis is typically associated
 with a decrease of pain on a short-term basis, but 50% of patients have pain 12 months
 after surgery. Often this leads to having repeat surgery to treat the endometriosis.
 Instead of having repeat surgery, some physicians use medications to prevent the pain
 and endometriosis from returning.

 -  The purpose of this study is to compare continuous oral contraceptives to
 depot-leuprolide for control of endometriosis-associated pelvic pain after surgical
 treatment of endometriosis. We will also be looking at the potential cost savings of
 using oral contraceptives compared to depot-leuprolide, as depot-leuprolide is an
 expensive medication.

 -  If the patient meets criteria, including confirmation of diagnosis of endometriosis, she
 will then undergo an intake visit consisting of obtaining informed consent and
 completion of several baseline questionnaires. This intake visit is estimated to last
 1-2 hours. After informed consent has been obtained, the subject will be randomized to
 one of the two treatment groups:One tablet of oral contraceptives (birth control pills)
 everyday and an injection of saline (a sterile salt solution with no medication effect)
 every 12 weeks for 48 weeks or One tablet of norethindrone everyday and an injection of
 depot-leuprolide every 12 weeks for 48 weeks.

 -  The patient will be seen one month after the first injection (Visit 1) and then at 12
 (Visit 2), 24 (Visit 3), 36 (Visit 4) and 48 (Visit 5) weeks. Blood pressure and weight
 will be recorded and a urine pregnancy test will be obtained. The Study Coordinator will
 review with the patient any concerns she might have and record any adverse events.
 Assessments of pain and quality of life will be made at weeks 4, 12, 24, 36 and 48 after
 the intake visit. An injection (leuprolide acetate or saline plus inert powder) will be
 given by an unblinded nurse at the intake visit, and at weeks 12, 24, and 36. In
 addition, at the end of each medication visit, the patient will be given a three month's
 supply of oral medication (capsules containing norethindrone acetate or a generic oral
 contraceptive with 30ug ethinyl estradiol and 0.15mg levonorgestrel).
Inclusion Criteria:

 -  Age greater than 18 and pre-menopausal.

 -  Pelvic pain of at least 3 months duration.

 -  Diagnosis of endometriosis by laparoscopy or laparotomy within three years of entry.
 The diagnosis of endometriosis will require either histology consistent with
 endometriosis or operative records indicating visual evidence of lesions consistent
 with endometriosis.

 -  Moderate to severe pelvic pain preoperatively attributable to endometriosis (average
 Numerical Rating Scale of 5 or more for three or more months).

 -  Willingness to comply with visit schedule and protocol.

 Exclusion Criteria:

 -  Use of oral contraceptives within one month of the surgery.

 -  Dose of Lupron within three months if given monthly or within five months if given
 3-month injection.

 -  Any disorder that represents a contraindication to the use of oral contraceptives
 (e.g. insulin-dependent diabetes mellitus, history of thrombophlebitis, hypertension,
 history of cardiovascular disease, smoker at 35 or more years of age) or GnRH analogs
 (e.g., history of osteopenia).

 -  History of hysterectomy and bilateral salpingoophorectomy.

 -  Positive pregnancy test at first postoperative (i.e, intake visit).

 -  Significant mental or chronic systemic illness that might confound pain assessment or
 the inability to complete the study.