Modified Atkins Diet Treatment for Adults With Drug-resistant Epilepsy
Modified Atkins Diet Treatment for Adults With Drug-resistant Epilepsy
In Oslo University Hospital, department of complex epilepsy, offer ketogenic diet to treat
 children with medically intractable epilepsy. From 2009 we added modified Atkins diet as a
 treatment option for children up to 18 years.

 We now initiate an open, prospective, randomized and controlled study with the aim to test
 the efficacy of treatment with modified Atkins diet in adults with focal and generalized
 epilepsy diagnoses, in order to evaluate whether this treatment should be offered to patients
 on a permanent basis.
Poorly controlled epilepsy in adults affects health and quality of life in many ways. Within
 this heterogenous population there are individuals who are motivated for a very strict diet
 in order to reduce seizures.

 Among adults with epilepsy 75 - 80 % are diagnosed with focal epilepsy, while 20 - 25 % have
 generalized onset of seizures.

 We plan to include 92 patients with focal epilepsy diagnosis. Those are randomized into diet
 and control groups.

 During the inclusion period we also treat patients with generalized epilepsy that qualify for
 participation, but these are not to be randomized, rather they will follow the diet group
 course. We assume 18 - 23 patients with generalized epilepsy will be included in the project.
Inclusion Criteria:

 -  Focal or generalized epilepsy diagnosis

 -  More than 3 recordable seizures per month

 -  BMI > 18,5

 -  Not responded to at least three 3 AEDs

 -  16 years or older

 -  Motivated to complete the diet after thorough information

 -  Capable of recording seizures

 -  Capable of preparing the diet

 Exclusion Criteria:

 -  Hypercholesterolemia, cardiovascular disease or kidney disease

 -  Been on modified Atkins diet for more than one week during the last year

 -  Status epilepticus last six months

 -  epilepsy surgery or VNS implant last year

 -  4 weeks continuous seizure freedom last 2 months

 -  PNES seizures

 -  other disease where dietary treatment is contraindicated

 -  usage of drugs or supplements that may interfere with diet or AED

 -  being pregnant or planning pregnancy