Outbreak of Hemolytic Uremic Syndrome Linked to Escherichia Coli of Serotype O104:H4
Outbreak of Hemolytic Uremic Syndrome Linked to Escherichia Coli of Serotype O104:H4
The Hemolytic Uremic Syndrome (HUS) in its typical form occurs after a food born infection
 with a shiga-toxin secreting bacteria, usually Escherichia coli of the O157H7 serotype. An
 outbreak of bloody diarrhea followed by HUS begun after a collective meal with 120 persons on
 June 8th, 2011 in Bègles, a city of Bordeaux urban area (CUB).

 At least 9 patients, 8 adults and 1 child have been involved in this HUS outbreak, E. coli of
 the O104:H4 serotype being demonstrated in most patients. This outbreak is remarkable by its
 preponderance in adults and women, its aggressiveness with multiorgan involvement , i.e. the
 kidneys, brain, liver, pancreas, and skin.

 Pathophysiology, prognosis, and treatment of typical HUS are poorly defined, particularly in
 adults who are usually not involved in typical E. coli O157H7 HUS.

 The aim of the present study is to gain knowledge on these different aspects of the HUS,
 including response to therapy.
Inclusion Criteria:

 -  All patients with HUS concomitant to the outbreak linked to E. coli O104:H4

 Exclusion Criteria:

 -  Patient not willing to participate or to sign informed consent