The Effects of Vitamin D3 Alone and in a Combination With Omega-3 on the Association of C-peptide With Glycemic Control
The Effects of Vitamin D3 Alone and in a Combination With Omega-3 on the Association of C-peptide With Glycemic Control
The Effects of Vitamin D3 alone and in a combination with omega-3 on the association of
 C-peptide with glycemic control
The data bout the effects of Vitamin D3 (VD3) alone and as a combination with omega-3 fatty
 acids (Omega-3FA) on the association between C-peptide (CP) and the glycated hemoglobin
 (HbA1c) is scarce, conflicting and nothing published in the literature review on the combined
 effect of VD3 and Omega-3FA as a combination on the association of CP with glycemic control.

 This study will be conducted to investigate the effects of (VD3) alone and as a combination
 with Omega-3FA on the association between CP as an insulin secretion marker, and glycemic
 control parameters represented by glycated Hemoglobin (HbA1c), on people with vitamin D
 deficiency (VDD).

 This randomized, placebo-controlled trial is designed to test the effects of (50,000 IU VD3/
 weekly) and (300mg omega-3FA/daily) separately and as a combination for eight weeks, on the
 serum levels of CP, 25-hydroxy vitamin D (25OHD) and HbA1c. this study will be carried out
 during winter on 120 healthy Jordanian males and females with VDD with age range (25-50)
 years. Fasting serum levels for 25OHD, CP, HbA1c, PTH, Calcium, Phosphate, ALT (Alanine
 aminotransferase) and Urea were assessed at baseline and at the end of the trial.
Inclusion Criteria:

 -  Aged (30-64)

 -  Have a medical diagnosis of VDD

 Exclusion Criteria:

 -  Chronic diseases, such as (osteoporosis, cancer, kidney disease(due to the association
 between prolonged administration of VD3 and kidney stones formation), an endocrine
 disorder, thalassemia).

 -  Documented history of allergic reactions to Omega-3FA supplementations