Prediction of Sphenoid Septation in MRI Compared With CT and Intraoperative Findings During Endoscopic Pituitary Adenoma Surgery
Prediction of Sphenoid Septation in MRI Compared With CT and Intraoperative Findings During Endoscopic Pituitary Adenoma Surgery
To investigate whether MRI is able to predict the exact anatomy and topography of the
 sphenoid sinus and its relationship to the sellar, parasellar und paraclinoid region and
 where CT yields more detailed information for the surgeon before trans-sphenoidal pituitary
 adenoma surgery.
The current research project addresses the question whether MRI alone is sufficient for
 preoperative planning and computer-assisted surgery (CAS) during standard trans-sphenoidal
 pituitary surgery and if situations can be identified, where additional CT yields more
 information for the surgeon.

 A comparison of MRI with CT of the skull base or paranasal sinuses and intraoperative Video
 documentation of the anatomical site will be used.

 50 patients operated the University hospital of Basel [USB] (Centre A) are consecutively
 included into the prospective part of the study. MRI is used to assess the standardized
 variables, confirmed by CT. Additionally, for the 50 prospectively collected patients,
 neuroimaging results are correlated with intraoperative evaluation during endoscopic
 trans-sphenoidal surgery or post-hoc with video analysis of the performed surgery.

 Between 20-50 patients operated at the University of Malaya Medical Centre [UMMC] and
 Specialist Centre [UMSC] (Centre B)will be included retro- and prospectively . MRI is used to
 assess the standardized variables and the results are correlated with intraoperative
 evaluation during endoscopic trans-sphenoidal surgery or post-hoc with video analysis of the
 performed surgery.
Inclusion Criteria:

 -  lndicated trans-nasal trans-sphenoidal surgery for an anterior skull base tumour with
 preoperative baseline MRI (Centre A and B) and baseline CT (Centre A).

 Exclusion Criteria:

 -  Previous trans-sphenoidal surgery

 -  Patients without CT, MRI or intraoperative endoscopic video