Minimally-Invasive Realtime Assessment of Continuous Lactate in Exercise
Minimally-Invasive Realtime Assessment of Continuous Lactate in Exercise
Lactate is a compound produced as a by-product of glycolysis. The increase in lactate
 concentration can result from a variety of causes, such as during anaerobic metabolism in
 exercise or haemodynamic shock in conditions such as sepsis.

 The study will aim to validate a novel microneedle-based minimally invasive device for the
 continuous measurement of lactate during exercise.
Lactate is a compound produced as a by-product of glycolysis. The increase in lactate
 concentration can result from a variety of causes, such as during anaerobic metabolism in
 exercise. The measurement of blood lactate during exercise has been routinely used to
 determine individual anaerobic thresholds, and optimise training in athletes.

 The measurement of the lactate trend requires multiple blood tests, and this can be
 uncomfortable. The need for repeated procedures may therefore restrict the full utility of
 the biomarker. Although point-of-care lactate measurements are possible, the barriers to
 initiating testing may also limit its role in clinical decision-making.

 The aim of the study is the validation of the microneedle-based lactate biosensor for
 real-time continuous lactate measurement in healthy volunteers during exercise as
 proof-of-concept.
Inclusion Criteria:

 1. Consenting adults ≥ 18 years old

 2. Healthy with no other previous medical history

 3. Able to perform moderately intensive exercise without difficulty for at least 30
 minutes continuously, and engages in regular aerobic exercise at least twice a week

 Exclusion Criteria:

 1. Active inflammatory skin condition such as eczema or dermatitis

 2. Active soft tissue infection or infection at any site

 3. Known hypersensitivity to any microneedle component or dressings

 4. Presence of any implantable electronic devices such as a pacemaker or stimulators