Radiofrequency in Differentiated Thyroid Cancer Metastatic Lymph Node: Prospective Study of Safety and Efficacy
Radiofrequency in Differentiated Thyroid Cancer Metastatic Lymph Node: Prospective Study of Safety and Efficacy
Radiofrequency (RF) could be technically feasible and effective in the treatment of lymph
 node metastases of differentiated thyroid cancer. It could constitute a minimally invasive
 and feasible therapeutic alternative in ambulatory, allowing a reduction of the tumoral
 volume sufficient to limit the symptoms even to induce a tumor remission, a normalization of
 the tumoral markers and a better quality of life.

 The aim of this study is to evaluate the anti-tumor echographic efficacy at 12 months of
 radiofrequency on lymph node (LN) metastasis of thyroid cancer
Inclusion Criteria:

 -  Patients over age of 18 years

 -  with differentiated thyroid cancer (papillary, follicular) histologically confirmed,
 and absence of anaplastic component

 -  Previous treatment by total thyroidectomy and cervical lymph node dissection.

 -  Previous treatment by at least 1 therapeutic radioactive iodine (minimum activity
 740MBq)

 -  Persistence on cervical ultrasound of at least 1 cervical metastatic lymph node,
 visible at ultrasound, small diameter between ≥10 mm and ≤30mm, volume maximum 20ml,
 spotted on a picture, and confirmed by cyto-punction

 -  Signed informed consent

 Exclusion Criteria:

 -  Location of LN metastasis with significant risk of local complication (nervous,
 vascular) according baseline ultrasound assessment

 -  Patient carrier of a pacemaker or a defibrillator

 -  Congenital or acquired hemostasis abnormality, anticoagulant therapy or double
 platelet antiaggregatory (aspirin and clopidogrel)

 -  Hypersensitivity to local anesthetic

 -  Poor general condition (performance status Eastern Cooperative Oncology Group (ECOG) >
 1)

 -  Survival estimated less than 12 months

 -  Patient who can't follow the instructions of RF therapy or who can't be followed
 during 2 years in order to meet the objectives of the study

 -  Non affiliation to a social security

 -  Pregnant or breast feeding women at the time of RF

 -  Beta hormone chorionic gonadotrope (HCG) positive test (pregnancy) before RF therapy

 -  Baseline cervical ultrasound, by expert operator trained to RF, not fulfilling
 feasibility criteria for RF realisation because of the location of LN metastasis or
 the way to reach it

 -  Controlateral recurrent palsy on nasofibroscopy