Study on Neoadjuvant Chemotherapy for Advanced Gastric Cancer
Study on Neoadjuvant Chemotherapy for Advanced Gastric Cancer
Gastric cancer is the second cause of cancer related death and China has the most gastric
 cancer patients in the world. Although systemic strategies, including adjuvant chemotherapy,
 postoperative chemoradiotherapy, perioperative chemotherapy, have evolved and showed benefits
 these years, the prognosis of advanced gastric cancer is still not satisfactory. Optimal
 regimens and optimal method administration is still being found. Neoadjuvant chemotherapy has
 many advantages, including downstaging the tumor, increasing R0 rate, early eradicating of
 micrometastasis. In previous trials, combination of paclitaxel and s-1 has showed safety and
 tolerance in recurrent or metastatic gastric cancer. Using liposome as a carrier, paclitaxel
 has a better histocompatibility and cellular affinity, resulting a improved stability and
 reduced toxicity. In this phase II trial, we are going to study the safety and feasibility of
 paclitaxel liposome plus s-1 as neoadjuvant chemotherapy.
Inclusion Criteria:

 -  Histologically confirmed gastric cancer

 -  Disease at clinical stage of resectable or potentially resectable(T3-4, N0-3, M0) by
 CT and endoscopic ultrasonography (EUS)

 -  Karnofsky performance status(KPS） ≥ 70

 -  No prior antitumor treatment is allowed, including chemotherapy, radiotherapy, immune
 therapy or target therapy

 -  Life expectancy more than 3 months

 -  Adequate organ function as defined below:White Blood Cell Count （WBC） ≥ 3.0*10^9/l,
 Absolute Neutrophil Count （ANC） ≥ 1.5*10^9/l, Hemoglobin ≥ 100 g/l, Platelets ≥
 100*10^9/l, Total Bilirubin （TBIL） ≤ 1.5mg/dl, Aspartate Aminotransferase（AST） and
 Alanine Aminotransferase(ALT) ≤ 2.5×ULN, Alkaline pPosphatase( ALP) ≤ 2.5×ULN, Renal
 Serum Creatinine < 1.5mg/dl

 -  Adequate lung and heart function

 Exclusion Criteria:

 -  ≥ grade 2 neuropathy

 -  History of malignancy

 -  With uncontrolled central nervous system metastasis

 -  Concurrent disease or condition that would interfere with the subject's safety
 (including current active hepatic, biliary, renal, respiratory disease, acute
 infection, severe malnutrition, uncontrolled diabetes hypertension et al)

 -  Severely inadequate intake of water or diet