The Safety and Efficacy of Clindamycin and Primaquine in the Treatment of Mild - Moderate Pneumocystis Carinii Pneumonia in Patients With AIDS
The Safety and Efficacy of Clindamycin and Primaquine in the Treatment of Mild - Moderate Pneumocystis Carinii Pneumonia in Patients With AIDS
To determine the safety and effectiveness of clindamycin and primaquine in the treatment of
 mild Pneumocystis carinii pneumonia (PCP) in AIDS patients.

 As many as 80 percent of AIDS patients experience at least one episode of PCP and about
 one-third of these patients have a recurrence of the disease. Drugs currently used for
 treatment of acute PCP are toxic to the majority of AIDS patients. The combination of
 clindamycin and primaquine reduces the numbers of PCP organisms in laboratory tests and in
 animal studies. Both drugs can be given orally, concentrate in lung tissue, and have been
 used safely in humans for treatment of other diseases. It is possible that the combination
 may prove to be as good or better than standard therapy for PCP and side effects may be less.
As many as 80 percent of AIDS patients experience at least one episode of PCP and about
 one-third of these patients have a recurrence of the disease. Drugs currently used for
 treatment of acute PCP are toxic to the majority of AIDS patients. The combination of
 clindamycin and primaquine reduces the numbers of PCP organisms in laboratory tests and in
 animal studies. Both drugs can be given orally, concentrate in lung tissue, and have been
 used safely in humans for treatment of other diseases. It is possible that the combination
 may prove to be as good or better than standard therapy for PCP and side effects may be less.

 The proposal for the first 20 patients enrolled in ACTG 044 initially called for an
 open-labelled, pilot study of intravenous (IV) clindamycin and primaquine therapy in patients
 with mild to moderate PCP. Preliminary results of the first 22 patients entered into ACTG 044
 indicate that the response rate to therapy was over 90 percent. The rate of discontinuation
 secondary to toxic side effects was only 20 percent. Additional uncontrolled studies have
 shown an excellent clinical response and safety profile in another 60 patients. The protocol
 has been amended to provide an all oral dosing regimen. An additional 20 patients with mild
 PCP will be enrolled and tested with oral clindamycin and primaquine on an outpatient basis.
 All patients will receive clindamycin and primaquine. Total duration of therapy will be 21
 days. Patients may be hospitalized at any time during the study as clinically indicated.
 Treatment with zidovudine may be started or resumed after completion of clindamycin /
 primaquine therapy.

 AMENDED: An additional 30 patients instead of 20 patients with mild PCP will be enrolled.
Inclusion Criteria

 Concurrent Medication:

 Allowed:

 -  Oral antiemetics.

 Patients must have the following for inclusion:

 -  HIV positive by ELISA, p24 antigen or culture.

 -  Pneumocystis carinii pneumonia (PCP).

 -  Patients must have an (A-a) DO2 < 40 mmHg on room air.

 -  Willingness to sign an informed consent.

 Prior Medication:

 Allowed:

 - Prophylaxis for Pneumocystis carinii pneumonia (PCP) with agents other than clindamycin
 and primaquine.

 Exclusion Criteria

 Concurrent Medication:

 Excluded:

 -  Hematotoxic therapy, including zidovudine (AZT) or ganciclovir.

 Patients with the following are excluded:

 -  History of allergy to clindamycin, lincomycin, or related drugs; or to primaquine or
 related drugs.

 -  Positive screen for G6PD deficiency, known NAD methemoglobin reductase deficiency,
 and/or known hemoglobin M abnormality.

 -  Concomitant conditions defined in Patient Exclusion Co-Existing Conditions.

 -  Any medical or social situation which, in the opinion of the investigator, would
 adversely affect participation in the study.

 -  Note:

 Patients may be enrolled while G6PD screen is pending, but must be withdrawn if results are
 not known within 5 days after entry.

 Prior Medication:

 Excluded within 14 days of study entry:

 -  Systemic steroids at doses exceeding physiologic replacement or other investigational
 agents.

 -  Excluded within 6 weeks of study entry:

 -  Prior institution of any antiprotozoal therapy for the current episode of Pneumocystis
 carinii pneumonia or prophylaxis.

 Patients must not have any of the following symptoms or diseases:

 -  History of allergy to clindamycin, lincomycin, or related drugs; or to primaquine or
 related drugs.

 -  Positive screen for G6PD deficiency, known NAD methemoglobin reductase deficiency,
 and/or known hemoglobin M abnormality.

 -  Diarrhea, defined as = or > 3 watery stools per day.

 -  Severe nausea and vomiting or other medical condition, such as ileus, that precludes
 oral therapy.

 -  Ventilator dependence or (A-a) DO2 = > 30 mm Hg.

 -  Any medical or social situation which, in the opinion of the investigator, would
 adversely affect participation in the study.

 -  Note:

 Patients may be enrolled while G6PD screen is pending, but must be withdrawn if results are
 not known within 5 days after entry.