Periodontitis and Atherosclerotic-related Arterial Stenosis
Periodontitis and Atherosclerotic-related Arterial Stenosis
This study aimed to evaluate the association between periodontitis and atherosclerosis of the
 cerebral vasculature in the Chinese population.
Periodontitis has been demonstrated as a risk factor for ischaemic stroke in several clinical
 studies. Atherosclerosis of the cerebral vasculatureis an important pathological process
 causing ischaemic stroke. The investigator's study aims to investigate the relationship
 between tooth loss(used as a surrogate of periodontal disease) and atherosclerotic-related
 arterial stenosis in the Chinese population. An estimated 1,000 participants that underwent
 cerebral angiography at Guangdong Provincial Hospital of Chinese Medicine between Apirl 2020
 and January 2022 will be recruited in this trial. Arterial stenosis features of each
 participants will be collected based on the results of digital subtraction angiography (DSA).
 The missing teeth counts of each participant will be collected and some of them will recieved
 comprehensive periodontal examination. Besides, blood samples will be collected in order to
 investigate the serum inflammatory markers(CRP,WBC,albumin,IL-6,IL-10). The relationship
 between tooth loss and atherosclerotic-related arterial stenosis will be analysed by
 regression models adjusted for conventional risk factors (sex,age, obesity,smoking,Alcohol
 drinking,diabetes,hypertension,hyperuricaemia,hyperhomocysteinaemia)
Inclusion Criteria:

 1. subjects who underwent cerebral angiography at Guangdong Provincial Hospital of
 Chinese Medicine from April 2020 to December 2021

 2. subjects who voluntarily participated in this study and provided informed consent.

 Exclusion Criteria:

 1. intracranial and extracranial artery stenosis caused by vascular inflammation,
 systemic connective tissue disease, and muscle fibre structure hypoplasia

 2. inability to cooperate with the investigation

 3. intracranial aneurysm and cerebral arteriovenous malformation confirmed by cerebral
 angiography

 4. receipt of periodontal treatment in the previous 24 months.