Exercise Training and Endothelial Function in Type 1 Diabetes
Exercise Training and Endothelial Function in Type 1 Diabetes
Endothelial dysfunction and vasoreactivity disorders are early subclinical complications of
 type 1 diabetes (T1D). In a preventive setting, in T1D patients still free of complications,
 the research of non-pharmacological interventions to improve endothelial function appears
 fundamental.

 In this randomized controlled trial, the effects of exercise training on endothelial function
 will be evaluated in T1D adults. Secondary objectives are to evaluate the exercise training
 effects on the micro and macrovascular function and exercise-induced tissue vasoreactivity
 and their possible neurometabolic consequences.

 An improvement in vascular function, particularly endothelium-dependent, as well as in
 neurometabolic profile, through this non-pharmacological strategy is expected
Inclusion Criteria:

 -  Covered by social security

 -  With a T1Diabete, diagnosed for at least 1 year, and free from macrovascular and
 microvascular diabetic complications.

 Exclusion Criteria:

 -  type 1 diabetes diagnoses for less than 1 year

 -  MODY diabetes, mitochondrial diabetes or type 2 diabetes

 -  presence of macrovascular and/or microvascular diabetic complications (retinopathy,
 nephropathy, neuropathy ,…)

 -  Obesity (Body Mass Index > 30 kg/m²

 -  Smokers

 -  Hypertension

 -  Disabling painful discomfort for trunk, upper or lower limb movements

 -  Active chronic disease or in remission (excluding type 1 diabetes)

 -  Head trauma in the past