Effects of Mannitol on Delayed Graft Function After Cadaveric Renal Transplantation
Effects of Mannitol on Delayed Graft Function After Cadaveric Renal Transplantation
In this study we want to evaluate the effect of mannitol on postoperative renal biomarkers in
 patient receiving cadaveric renal transplantation. Furthermore we want to evaluate the effect
 of mannitol on perioperative redox status in patients receiving renal transplantation using
 the oxidation-reduction potentials assessed with the RedoxSYS®system.

 We are planning to perform a double-blind randomized controlled trial. In the study, mannitol
 20% with a dose of 1g / kg / BW (5 ml / kg / BW) will be compared to placebo with NaCl 0.9%
 in the dose of 5 ml / kg / BW. Patients will be randomized to receive either the mannitol or
 NaCl. The follow-up of the study is 24 hours. The following biomarkers will be determined
 befor induction of anesthesia and 24 hours after administration of study medication: CCL2,
 CHI3LI, GH, HGF, MMP1, MMP8, Tie2, TNF-R1, VCAM-1, KIM-1, Cystatin C, FGF23, IGFB7, NGAL and
 IL 18.

 Furthermore we want to perform sORP and cORP before induction of anesthesia, just before
 bolus of mannitol, 5 min after bolus of mannitol and after operation in anesthetic recovery
 room.

 Data will be collected, compared and published at the end of the study. It is planned to
 include a total of 34 patients in the study.
Inclusion Criteria: all patients with end stage renal diseases -

 Exclusion Criteria: Patients younger than 18 years of age or older than 80, alergy to
 mannitol, Pregnancy, Breast-feed

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