The Clinical Efficacy of Non-steroidal Anti-inflammation Drugs in Patients With Benign Prostatic Hyperplasia
The Clinical Efficacy of Non-steroidal Anti-inflammation Drugs in Patients With Benign Prostatic Hyperplasia
Non-steroidal Anti-inflammation Drugs can effectively reduce the lower urinary tract symptoms
 from benign prostatic hyperplasia
Inclusion Criteria:

 -  Who had the treatment of BPH with alpha-1 blockers for more than 3 months

 -  Who have the IPSS(International Prostatic Symptom Score) >= 15

 -  Who have the maximum flow rate(Qmax) < 15 with voided volume > 150mL

 -  Who have the PPBC(patient's perception of bladder condition) >= 3 (The PPBC was
 assessed by the use of a six point ordered categorical scale(1-6 point). The higher
 score means the higher bother)

 -  Who had the PSA level < 4 ng/mL within 6 months (But, the patient who are revealed not
 to have prostate cancer by prostate biopsy can be included even if he had PSA level of
 4-10 ng/mL)

 -  Who underwent the transrectal ultrasound of prostate within 6 months

 -  Who can understand this study and can give the informed consent

 Exclusion Criteria:

 -  Who had regular intake of 5-alpha reductase inhibitor or NSAID within 6 months before
 screening

 -  Who have peptic ulcer and/or asthma

 -  Who have urologic malignancies such as prostate cancer and bladder cancer

 -  Who have urethral strictures, large bladder diverticuli, and bladder neck contractures

 -  Who had surgical treatment for BPH

 -  Who have histories of bladder and/or urethra

 -  Who have serum PSA level more than 10 ng/ml

 -  Who have histories of orthostatic hypotension

 -  Who have serum creatinine level more than 2.0 mg/dl

 -  Who have serum ALT and/or AST level more than 1.5 times of normal upper limit

 -  Who have heart failure

 -  Who have histories of bacterial prostatitis within 1 year

 -  Who have histories of active urinary tract infection within 1 month

 -  Who have histories of the biopsy of bladder and prostate within 1 month

 -  Who are unable to void

 -  Who use pads because of incontinences

 -  Who have hypersensitivities for alpha blockers that include quinazoline, NSAID,
 aspirin, sulfonamide

 -  Who have histories of unstable angina, myocardial infarction, and cerebrovascular
 accident within 6 months

 -  Who have neurogenic bladder due to multiple sclerosis, Parkinson's disease, Spinal
 injuries and etc.

 -  Who have thinking disturbances

 -  Who have histories of abuses of alcohol and/or other drugs

 -  Who seem to be not fit to this study by the decision of investigators