Early Aggressive Correction of Severe Acidosis With Tris-hydroxymethylaminomethane (THAM)
Early Aggressive Correction of Severe Acidosis With Tris-hydroxymethylaminomethane (THAM)
This study involved the medical record review of resuscitation records for all
 severely-injured trauma patients requiring emergent surgical intervention and significant
 acidosis from 2005 through 2009.
The study objective is to assess the efficacy of fluid resuscitation and treatment of
 acidosis in patients who were managed with use of amine buffer THAM
 (tris-hydroxymethlaminomethane) versus those who were resuscitated with crystalloids or
 colloids and may have have received sodium bicarbonate for the treatment of acidosis.
Inclusion Criteria:

 -  Presence of severe traumatic injury requiring emergent surgery

 -  Peri-operative development of severe acidosis (defined arterial ph less than or equal
 to 7.20 or base deficit greater than or equal to 10 mEq/dL)

 -  Acidosis was treated with either THAM or "usual care" (defined as crystalloid either
 or without sodium bicarbonate)

 Exclusion Criteria:

 -  None