Safety and Efficacy of Topamax Versus Carbamazepine in Benign Rolandic Epilepsy
Safety and Efficacy of Topamax Versus Carbamazepine in Benign Rolandic Epilepsy
The purpose of this study is to determine the efficacy and safety of Topiramate in comparison
 to Carbamazepine in Benign rolandic epilepsy.
Benign rolandic epilepsy (BRE) is a common seizure disorder confined solely to children. The
 disorder is marked clinically by nocturnal generalized tonic-clonic seizures and diurnal
 seizures consisting of simple partial seizures consisting of brief unilateral facial clonic
 activity, dysphasia, and drooling. The EEG abnormalities are unique, consisting of generally
 high amplitude, centrotemporal spikes that are activated by sleep. The seizures typically
 begin in the first decade and almost always stop by age 16 years. The seizures are usually
 infrequent although clusters of seizures do occur. When the physician elects to treat, the
 seizures are usually easily controlled. This is a randomized, open label, active controlled,
 multi-center based clinical trial to determine the efficacy and safety of Topiramate
 comparing with Carbamazepine in Benign rolandic epilepsy. The study hypothesis is that
 topiramate will be more effective in treatment of Benign rolandic epilepsy than
 Carbamazepine, as evaluated by seizure-free rate at 24 weeks and Intellectual Functioning :
 KEDI-WISC (Korean Educational Development Institute Wechsler Intelligence Scale for
 Children-Revised) and is generally well-tolerated.

 Topiramate (target dose) 4mg/kg/day, B.I.D, oral, for 24 weeks, carbamazepine(target dose)
 30mg/kg/day, B.I.D, oral, for 24 weeks.
Inclusion Criteria:

 -  Subjects whose guardians submitted written consent

 -  Subjects with more than 2 seizures in last 1 year

 -  Subjects showing one of the following additional criteria

 -  Psychological burden due to seizure

 -  Seizure in daytime

 -  More than 3 seizures in last 6 month

 -  Convulsive seizure

 Exclusion Criteria:

 -  Abnormalities on MRI, EEG

 -  Mental retardation

 -  History of seizure relapse

 -  Seizures due to organic causes

 -  Medically serious acute or chronic disease or progressive and degenerative disorders

 -  Patients who have received an investigational medication