Classifying Ectopia Lentis in Marfan Syndrome Into Five Grades of Increasing Severity
Classifying Ectopia Lentis in Marfan Syndrome Into Five Grades of Increasing Severity
Marfan syndrome is characterized by musculoskeletal manifestations, cardiovascular disease
 and ocular abnormalities, particularly ectopia lentis. Diagnosis depends on clinical
 evaluation, family history and molecular data: mutation in the fibrillin-1 gene (FBN1).
 Ectopia lentis is the most common ocular manifestation in Marfan syndrome with FBN1 mutation
 and is relatively specific to this disease when associated with other features. However,
 clinical examinations for identifying ectopia lentis have not really been codified. The
 purpose of this study is to describe a 5-grade classification of increasing severity for
 ectopia lentis based on clinical examination and to evaluate the predictive value for the
 early grades of ectopia lentis in order to help characterize this major clinical diagnosis
 criterion.
Inclusion Criteria:

 -  MFS patient, clinical diagnosis according to revised Ghent criteria, confirmed by FBN1
 mutation.

 -  Relatives of MFS patients with none of the clinical features of MFS and in whom
 testing for the familial FBN1 mutation was negative.

 Exclusion Criteria:

 -  Patients who had surgery for ectopia lentis

 -  Patients for whom dilation was not optimal.