Study of Retinal Vascular Parameters in Patients With Wilson's Disease
Study of Retinal Vascular Parameters in Patients With Wilson's Disease
The rare disease reference center " Wilson disease and other rare copper-related diseases" of
 the Rothschild Foundation follows a large number of patients with Wilson's with varying
 degrees of impairment and located at different times of their care.

 Many people with Wilson's disease have a characteristic greenish-brown ring, known as
 Kayser-Fleischer, appearing at the periphery of the cornea due to a deposit of copper at the
 Descemet membrane. As a general rule, if the patient is compliant with his treatment, the
 ring usually disappears within a few years, although it may persist in some patients.
 However, apart from the stage of diagnosis, and the evolution of the ring, ophthalmological
 examinations are little used for the follow-up of these patients.

 The objective of this study is to describe the retinal parameters, in particular vascular
 with two new retinal imaging technologies (OCT-A :Optical Coherence Tomography-Angiography ,
 Adaptive optics) in patients with Wilson's disease and to correlate them with the parameters
 of the usual follow-up of these patients (hepatic assessment, exchangeable plasma copper,
 neurological scores, compliance, etc.).
Inclusion Criteria:

 -  Wilson's disease with Ferenci score ≥4

 Exclusion Criteria:

 -  Neurological or behavioral handicap that does not allow for ophthalmological
 examinations

 -  Hepatic decompensation that does not allow for ophthalmological examinations

 -  Pregnant or breastfeeding woman