Microbubble-Enhanced Clotbust Treatment of Acute Ischemic Stroke
Microbubble-Enhanced Clotbust Treatment of Acute Ischemic Stroke
The study is designed to examine the safety, tolerability, and activity of a combination of
 microbubbles (perflutren lipid microsphere [Definity®]) and continuous monitoring with 2 MHz
 transcranial Doppler ultrasound (TCD) as an adjunctive therapy to tissue plasminogen
 activator (tPA) treatment in subjects with acute ischemic stroke.
Inclusion Criteria:

 -  Measurable focal neurological deficit (National Institutes of Health Stroke Scale
 [NIHSS] score > 4 points)

 -  tPA eligible

 -  Occlusion of the middle cerebral artery

 Exclusion Criteria:

 -  Right to left cardiac shunt

 -  Uncontrolled hypertension

 -  Absent temporal windows