Cairo is an unincorporated community in Malheur County, Oregon, United States. Its elevation is 2192 ft above sea level. It is about 4 mi southwest of Ontario and a half mile north of Cairo Junction, where U.S. Route 20 and U.S. Route 26, running concurrently with Oregon Route 201, turn south towards Nyssa. Route 201 also continues north from Cairo Junction through Cairo and towards Ontario.
Cairo is about 4 mi southwest of Ontario.