The Mercedes-Benz W221 is a chassis code of S-Class, the successor of the Mercedes-Benz S-Class (W220) and the predecessor of the Mercedes-Benz S-Class (W222). The S-Class are the flagship vehicles of Mercedes-Benz and each generation typically introduces a range of technical innovations and developments that over time will find their way into smaller cars.
The W221 is the last S-Class vehicle made by Mercedes-Benz.