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HomeIssue 2O. percent epithelial and stromal cell proliferation index. (A) Proportion of parenchymal tissue composedIssue 2O. percent epithelial and stromal cell proliferation index. (A) Proportion of parenchymal tissue composed
Issue 2O. percent epithelial and stromal cell proliferation index. (A) Proportion of parenchymal tissue composed
ack1 inhibitor April 28, 2022 April 28, 2022
Issue 2O. percent epithelial and stromal cell proliferation index. (A) Proportion of parenchymal tissue composed of epithelium percent epithelial and stromal cell proliferation (mean (A) Proportion of parenchymal tissue composed of epithelium average enrichment index. common deviation) of COL10 animals from day one particular to seven (parenchymal epithelial location; PEA) and (B) % of epithelial and stromal cells in parenchymal compartment stained % of epithelial and stromal cells in parenchymal compartment stained postnatal was three.48 1.21, and COL20 averaged 3.38 0.82 (Figure 5). The yield of DNA with KI67 asas marker of proliferating population in mammary tissue of baseline (n = 6; gray) animals collected immediately with KI67 a a marker of proliferating population in mammary tissue of baseline (n = six; gray) animals collected per unit of mammary parenchymal tissue, while numerically higher in COL20 (0.66 right after birth and in neonatal piglets fed 10 (COL10; n = 7; black) or 20 (COL20; n = 6; white) of birth weight of colostrum 0.08 ng DNA/mg tissue) treated gilts, was not distinct (p = 0.2) from COL10 (0.55 0.21 over the very first 24 h postnatal, returned to sow to suckle and after that euthanized on day seven postnatal. Inside the boxplot, the ng DNA/mg tissue) animals (Table 4). `x' indicates imply, and line indicates median. Unique letters indicate a substantial difference at p 0.05.Evaluation of percent 3-Hydroxymandelic Acid manufacturer deuterium oxide in piglets' plasma across the seven days of la-Figure five. Percent deuterium oxide (D2O) in plasma of neonatal gilts at birth (day 0) and 1, three, five and Figure 5. % deuterium oxide (D2 O) in plasma of neonatal gilts at birth (day 0) and 1, 3, 5 and 77days postnatal. Open and cross-hatched symbols represent percent deuterium in COL20, and filled days postnatal. Open and cross-hatched symbols represent percent deuterium in COL20, and filled symbols represent COL10 animals across the 5 days sampled. The dashed line and gray markers symbols represent COL10 animals across the five days sampled. The dashed line and gray markers represent the mean % deuterium across all animals. Distinct letters indicate a considerable difrepresent the mean percent deuterium across all animals. Distinct letters indicate a considerable ference at p 0.05. distinction at p 0.05. Table 4. DNA yield, mean fraction (f) and fractional synthetic price (FSR) of DNA and protein along with the these elements in between mammary morphological capabilities and days postnatal in plus the ratio ofrelationship in mammary parenchymal tissue more than the first seven mammary DNAgilts protein(COL10, n = 7) or 20 (COL20, n = (Table 5). weight colostrum over relationship (r =birth. fed 10 f and FSR were investigated 7) of birth A relatively powerful the very first 24 h after 0.86;p 0.0001) between percent KI67 labeled stroma, and epithelial cells was CP-31398 Autophagy evident on postnatal day Variable seven. PEA was related to percent KI67 labeled stroma (r = 0.75; p 0.001) COL10 COL20 SEM p and KI67 labeled epithelial cells (r = 0.66; p = 0.01). The percent of KI67 labeled epithelial cellsDNA content material day seven was positively0.55 0.05) associated with protein f (r = 0.61) on postnatal (ng/mg tissue) (p 0.66 0.15 0.20 and FSR (r = 0.63). There was a trend for any connection in between parenchymal epithelial area as well as the fraction of newly synthesized DNA (r = 0.48; p = 0.09), 0.06 also as a trend for Mammary Protein f 0.70 0.68 0.Mammary Protein FSR ( /day) Mammary DNA f 0.18 0.29 0.18 0.29 0.02.
Death [13]. Systemic dexamethasone therapy for BPD sufferers has also been shown to alter particular
Death [13]. Systemic dexamethasone therapy for BPD sufferers has also been shown to alter particular peripheral blood lymphocyte populations, notably a lower in CD4+T-cells [2]. CD4+T-cells have diverse roles and subsets, active in innate and adaptive immune function and regulation [14]. Interestingly, peripheral CD4+T-cells have also been shown to be drastically decrease in premature infants who sooner or later develop BPD when measured during the very first two weeks of life, whereas other peripheral blood lymphocyte populations, which include CD8+ T-cells, lack such differences [15]. CXCR3, a chemokine receptor very expressed on sort 1 helper (Th1) T-cells, represents a different location of interest in T-cell mediated inflammation. CXCR3 expression regulates trafficking of Th1 cells to injured tissue to amplify the inflammatory response [16]. Furthermore, a sizable longitudinal cohort study demonstrated that T-cell phenotype at birth was influenced by gestational age, with CD4+ T-cells transitioning from CD31TNF-+ mid-gestation toward a CD31+IL-8+ phenotype closer to full term gestation. Preterm infants low in CD31+IL8+CD4+T cells at discharge had been located to become at higher danger for post-discharge respiratory complications, emphasizing the highly effective function of T-cell function in respiratory morbidity and mortality of preterm infants [17]. There is certainly restricted understanding in the significance of T-cell expression profiles and cytokines in the lungs of GS-441524 Purity & Documentation ventilated preterm infants. We hypothesized that the administration of postnatal dexamethasone to ventilated preterm infants reduces the pro-inflammatory nature of T-cells as measured by intracellular cytokine production. We utilized a panel of T-cell markers and to specifically examine expression on T-cells of typical pro-inflammatory cytokines, because these research have been exploratory within a modest cohort of sufferers. T-cells have been studied because CD3+ T-cells were shown in previously unpublished but nationally presented data to be far more prevalent inside the lungs of deceased infants with BPD compared with equivalent corrected gestational age infants who died with no lung disease [18]. CXCR3 was studied based on its known association with adult idiopathic fibrosis [19]. IL-6 was integrated because higher TA IL-6 on day 3 of life is connected with later BPD [20]. If our hypothesis is confirmed, better description of cytokine expression and receptor modifications may elucidate the mechanism of dexamethasone positively influencing respiratory outcomes in these infants. Characterization and clinical correlation of those elements may well allow improved choices regarding the timing, initiation, and duration of corticosteroids in ventilator-dependent preterm infants, or probably inform more certain treatments, sparing the use of steroids with their broad range of effects and unwanted side effects.Kids 2021, eight,3 of2. Components and Approaches two.1. Ethics This study was performed with all the approval of the Healthcare University of South Carolina Institutional Overview Board (IRB Darapladib In Vivo Protocol 00018389, authorized 13 August 2012). All subjects' parents offered written informed consent. 2.2. Patient Traits This pilot study utilized a potential observational cohort with convenience sampling. Infants have been chosen for inclusion if they have been born amongst 23 0/7 weeks and 28 6/7 weeks, and mechanically ventilated for a minimum of 14 days before initiation of dexamethasone. Infants who received any prior corticosteroids or had any life-threatening congenital anomalies had been excl.
Sformation properties on the distortion and residual stresses of the gears. These outcomes offer further
Sformation properties on the distortion and residual stresses of the gears. These outcomes offer further insight into the impact of Ti on the phase transformation properties and also reveal the impact with the phase transformation properties on the distortion and pressure fields generated inside the carburizing quench. This will be of good use in predicting the mechanical strength and properties of carburized quenched gears and suggesting optimizing processes. 2. Summary of your Theoretical Model The carburizing and quenching course of action enables the phase transformation structure from the material to be changed. In particular, mechanical components, like gears, bearings and rollers, which spot high demands around the surface with regards to resistance to friction and put on, is usually substantially hardened and enhanced by the carburizing procedure. On the other hand, the carburizing and quenching approach includes a complex continuous medium thermodynamic theory and calls for consideration on the coupling involving the carbon concentration diffusion field, temperature field, phase transformation kinetics and tissue distribution, as well because the inelastic stress/��-Amanitin site strain field (as shown in Figure 1) [60].Coatings 2021, 11, 1224 PEER Critique Coatings 2021, 11, x FORof 14 33ofFigure 1. Metallo-thermal-mechanical theory in heat remedy processes. Figure 1. Metallo-thermal-mechanical theory in heat PPADS tetrasodium medchemexpress therapy processes.In this theory, the coupling effects the following aspects are deemed. The very first can be a In this theory, the coupling effects ofof the following aspects are regarded as. The initial comprehensive consideration of the effects on material properties and phase transformation is actually a complete consideration in the effects on material properties and phase transforkinetics because of the diffusion of carbon ions ions inside the and the creation of of a gradimation kinetics as a consequence of the diffusion of carbon within the steelsteel and also the creation a gradient distribution. The second considers the effect of temperature adjustments on the nucleation and ent distribution. The second considers the effect of temperature adjustments around the nucleation growth of phase distortion and around the temperature field because of the generation of latent and development of phase distortion and around the temperature field as a consequence of the generation of laheat in the phase transformation. The growth of the phase transformation has an effect tent heat from the phase transformation. The growth with the phase transformation has an on the anxiety and strain fields as the phase transformation brings about neighborhood expansion or impact on the anxiety and strain fields because the phase transformation brings about regional expancontraction. Conversely, the stress/strain fields also can inhibit or induce the nucleation sion or contraction. Conversely, the stress/strain fields also can inhibit or induce the nuand growth on the phase transformation. The third aspect is the fact that alterations inside the temperature cleation and growth from the phase transformation. The third aspect is the fact that alterations within the field inevitably cause expansion or contraction of the material, i.e., thermal strain. When temperature field inevitably lead to expansion or contraction of your material, i.e., thermal massive distortions take place inside the material because of processing and heat remedy, strain. When big distortions happen inside the material as a result of processing and heat heat generation also occurs, which affects the adjust inside the temperature field. That is the therapy, heat genera.
Muscle, mice have been sacrificed at 18 months of age and also the gastrocnemius and
Muscle, mice have been sacrificed at 18 months of age and also the gastrocnemius and vastus lateralis had been dissected and weighed on a laboratory scale. To weigh the WAT, mice have been sacrificed at 18 months of age, and also the epididymal, mesenteric, and inguinal WATs have been dissected and weighed on a laboratory scale. The motor coordination was assessed at various months of age working with the rotarod test by recording the length of time that mice could remain on the rod ("latency to fall"), rotating at a rate of 4 rpm, accelerating to 40 rpm in 300 s. Muscle strength was assessed applying a computerized grip strength meter (Model 47200, Ugo-Basile, Varese, Italy). The experimenter held the mouse gently by the base from the tail, allowing the animal to grab the metal bar with all the forelimbs prior to becoming gently pulled till it released its grip. The peak force of each and every measurement was automatically recorded by the device and expressed in grams (g). The hindlimb grip strength of every single mouse was measured in duplicate with at least 1 min between measurements [1]. two.two. Cell Culture and Cell Assays 3T3-L1 preadipocytes (ECACC #: 86052701; lot CB 2618) have been obtained from the cell bank of your University of Granada and maintained in DMEM PHA 568487 custom synthesis containing 10 fetal calf serum (FCS) within a humidified atmosphere of 5 CO2 at 37 C. The differentiation in the preadipocytes was induced two days Biotinylated Proteins Gene ID post-confluence (day 0) following the manufacturer's instructions (DIF001-1KT; Merck Life Science S.L.U, Madrid, Spain)) by means of the addition of 0.5 mM 3-isobutyl-1-methylxanthine (IBMX), 1 dexamethasone, and 10 /mL insulin (several every day insulin (MDI)) for 2 days. Subsequently, the culture medium was changed to DMEM and 10 fetal bovine serum (FBS) containing insulin. Just after 2 days, the medium was replaced with DMEM and ten FBS, and also the cells have been incubated for a further 2 days until the cells have been harvested to be made use of within the experiments described beneath. C2C12 myocytes (ECACC #: 91031101; lot 08F021) were obtained in the cell bank at the University of Granada and maintained in DMEM containing 10 FBS inside a humidified atmosphere of five CO2 at 37 C. The differentiation in the preadipocytes was induced 1-day post-confluence (day 0) by changing to a 1 FBS medium. Subsequently, the culture medium was changed to DMEM and 1 FBS. The medium was changed every other day plus the cells had been harvested to become used within the experiments described below.Biomedicines 2021, 9,4 ofIn both cell types, namely, 3T3-L1 and C2C12, each and every assay was carried out in certainly one of three experimental conditions: proliferative, differentiative, or proliferative + differentiative. Proliferative circumstances had been created in both sorts of cells just after cell splitting, and cells have been collected upon reaching the confluency at day 7. Differentiative conditions were initiated in both cell forms when the cells reached confluency. In 3T3-L1 cells, the differentiation was induced together with the differentiation medium described above. In the C2C12 cells, differentiation was induced in a medium with 1 FBS, as described above. The cells were collected on day 7. Proliferative + differentiative situations combined both procedures within the similar experiment. -RA was added at a final concentration of 1 mM every other day in each experimental situation. To visualize the lipid droplets, the 3T3-L1 cells had been fixed in formalin and stained with Oil Red resolution on days two, four, and six in both the proliferative and proliferative + differentiative conditions. Cell viability a.
Avenues for drug delivery and tumor LAU159 Cancer diagnosis by way of imaging.Citation: Rajan, C.;
Avenues for drug delivery and tumor LAU159 Cancer diagnosis by way of imaging.Citation: Rajan, C.; Seema, J.; Chen, Y.-W.; Chen, T.-C.; Lin, M.-H.; Lin, C.-H.; Hwang, D.W.-H. A Gadolinium DO3A Amide m-Phenyl Boronic Acid MRI Probe for Targeted Imaging of Sialated Solid Tumors. Biomedicines 2021, 9, 1459. https:// doi.org/10.3390/biomedicines9101459 Academic Editor: Paul R ch Received: 22 September 2021 Accepted: 12 October 2021 Published: 13 OctoberKeywords: MRI; contrast agent; CA; DOTA; PBA; SA1. Introduction Magnetic resonance (MR) spectroscopy/imaging has turn out to be among the most effective analytical techniques for any diverse array of applications in chemistry, physics, biology, materials, and medicine. The aims of this study had been to develop revolutionary bio-inspired materials and techniques for sensing, and to considerably enhance the sensitivity of detection of biomarkers employing MR spectroscopy and imaging, a fundamental challenge in modern day MR. Sensitivity enhancement is especially crucial for the early detection of diseases, for example cancers and dementia, utilizing MR molecular imaging [1,2]. Gadolinium contrast agents that enhance the top quality of magnetic resonance imaging (MRI) are extensively utilised in the diagnosis and treatment of tumors [3]. Although an incredible deal of study had been carried out more than the previous decade, it's pretty hard to distinguish involving tumor regions and normal regions, considering that only a little quantity of contrast agent is retained in the tumor web site by way of the enhanced permeability retention impact. Studies have revealed that, immediately after the administration of gadolinium-based contrast agents, sufferers with renal failure create nephrogenic systemic fibrosis (NSF) [6]. Hence, the European Medicine Agency has recommended restrictions on the use of some intravenous linear MRI contrast agents so as to prevent the adverse overall health effects associated with the administration of gadolinium [7]. For that reason, the synthesis of macrocyclic chelator CAs with higher stability, selectivity, and less toxicity has develop into a focus of investigation. Comprehensive study is becoming undertaken toward the improvement of novel gadolinium probes with selective targeting, higher tumor retention, and fast clearance from nontarget tissues [8]. Contrast agents are frequently conjugated to specific targeting agents to actively target the selective moieties which are expressed around the tumor surface. Although these kinds of techniques show guarantee, a lot of concerns, which include the long-term stability and in vivo integrity ofPublisher's Note: MDPI stays neutral with regard to jurisdictional claims in Apoptosis| Published maps and institutional affiliations.Copyright: 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access report distributed below the terms and circumstances of your Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).Biomedicines 2021, 9, 1459. https://doi.org/10.3390/biomedicineshttps://www.mdpi.com/journal/biomedicinesBiomedicines 2021, 9,two ofthe newly created contrast agents, remain unanswered [91]. Regardless of the high targeting efficiency, rapid nonrenal clearable compounds can exhibit serious accumulation in the liver and spleen, raising concerns of long-term toxicity. Therefore, elimination of contrast agents will be the crucial aspect to be thought of. Contrast agents with fast elimination are preferred for clinical use considering that their accumulation in other organs could be proficiently minimized. Phenyl boronic acid (PBA), which selectively recogniz.
Cursor product ion pair of 90 m/z 44 m/z; 91 m/z 45
Cursor product ion pair of 90 m/z 44 m/z; 91 m/z 45 m/z; 92 m/z 46 m/z; 93 m/z 47 m/z; and 94 m/z 48 m/z; so as to measure the intensity/area of isotopomer (M) with no heavy isotopes (M0), one particular (M+1), two (M+2), 3 (M+3) and 4 (M+4), respectively. Supplementary Phenylacetylglutamine Formula Components Details S1 shows the distribution of alanine M0, M+1, and so forth., in a sample from an unlabeled animal (blank) and eight samples from D2 O labeled animals, with corresponding LC/MS spectra of samples. 2.5.7. Mass Isotopomer Distribution Evaluation (MIDA) of Adenosine and Alanine for Calculation on the Fraction (f) of DNA and Protein Newly Synthesize plus the Fractional Synthetic Rate (FSR) of DNA and Protein To figure out the % of newly synthesized DNA and proteins, the % of enrichment (p) was calculated because the mean percentage of D2 O enrichment from postnatal day 1 to day seven in every single piglet. LC-MS/MS analysis of adenosine and alanine supplied the intensities for M0 to M+2 and M0 to M+4, respectively. The percentage of M0 ( M0) at birth and day seven ( M07 ) was calculated as the intensity M0 isotopomer divided by the total from the intensities for all isotopomers measured for adenosine and alanine. The distinction between M0 and M0t is defined as EM0t [14]. EM0t = M0t – M0 (1)EM0t can be defined as the modifications on M0 after a precise time (t) of exposure to D2 O and is, in portion, determined by the synthetic ratio (balance involving synthesis and degradation) of DNA, as tissue cells are inside a continual turnover of division and death. Each and every cell includes a different turnover based on its biological functions and properties. Nourseothricin Protocol Additionally, the speed of synthesis of dA, or FSR, could be modified by physiological events or experimental treatment options. The M0 (max M0 when one hundred from the DNA are de novo synthesized) is usually calculated determined by M0 , p and n. Where p is definitely the probability of getting labeled, which is the percent enrichment of D2O, and n is definitely the number of hydrogens within a molecule that may be labeled (`replace') hydrogen. The following formulas for DNA synthetic rate had been adapted from [16,17]: M0 = (1 – p)n M0 (two) After we know the M0 , we're able to elucidate EM0 , related to EM0t . EM0 = M0 – M0 EM0 is definitely the M0 when 100 of your DNA is turned over. After EM0t and EM0 are determined, fractional synthesis (f ) is calculated. f = EM0t /EM0 FSR = -ln (1 – f )/t 2.6. Statistical Evaluation All statistical analyses were performed in SAS (version 9.four; Cary, NC, USA). Amino acids that had been beneath the detectable limit had been assigned a worth that was one-fifth the highest value, which was beneath the lowest value. Procs Mixed model was utilised with treatment run because the class. Normality was checked by running the residuals within the model. All statistical models included therapy and birthweight. Birthweight was excluded in the model if not important (p 0.05). The least-square implies were performed making use of the Tukey-Kramer approach, having a pairwise comparison. p 0.05 was deemed important, with p-value 0.05, but 0.1 discussed as a tendency. Bodyweight and average daily achieve have been run with Procs Mixed with remedy and day as fixed effects using the day as a repeated measurement. Therapy by day interactions and birthweights had been included inside the model and removed if not significant (p 0.05). Proc corr was made use of for correlations. (four) (5) (3)Animals 2021, 11,ten of3. Results 3.1. Colostrum Composition as well as the Effect of Colostrum Intake on Neonate's Plasma Insulin, Gl.
Ple was the ratio from the geometric mean of your sample to the average across
Ple was the ratio from the geometric mean of your sample to the average across all geometric implies. For each and every sample, we divided all gene counts by the corresponding Ciprofloxacin (hydrochloride monohydrate) Epigenetics scaling element. Lastly, to normalize for variations in RNA input, we utilized the same system as was employed in good manage normalization, except that right here, geometric indicates had been calculated more than 40 housekeeping genes (Supplementary Table S2). The outcomes are expressed in fold alter induction. two.5. Principal Component Evaluation Principal element Methoxyfenozide manufacturer Analysis (PCA) was performed employing the sklearn.decomposition.PCA function inside the Python package scikit find out (v0.22). two.6. Differential Gene Expression Evaluation Normalized counts were analyzed in accordance with the study's objectives. The expression of each and every single gene inside the categories was compared by way of t-test applying the nSolver four.0 application. The p-value and false discovery rate-adjusted p-value (Benjamini ochberg) have been computed. Genes with an adjusted p-value 0.05 and an absolute log2 fold transform 1.0 were deemed to become drastically differentially expressed. two.7. Biological Pathway Enrichment Analysis Biological pathway enrichments had been performed on the drastically differentially expressed genes by means of the enrichGO function (FDR 0.05) employing the molecular function (MF) annotation tool in Gene Ontology GO.db_v3.ten.0 (Bioconductor R3.6.3, https:// www.bioconductor.org/, accessed on 27 August 2021). The enrichGO and the cnet (category net plot utilised for visualization) functions had been executed by ClusterProfiler v3.14.three (Bioconductor R3.six.three, https://www.bioconductor.org/, accessed on 27 August 2021). 2.8. Immunohistochemistry Tissue samples had been processed as described previously [16]. In total, 14 comprehensive mole and 15 postmolar choriocarcinoma samples had been integrated for immunohistochemical evaluation. Monoclonal Sall4 antibody (Sigma ldrich, 38070 Saint Quentin Fallavier, France) was utilised at 0.two /mL. To quantify the intensity in the immunostainings, the photos had been morphometrically analyzed using Image J software. three. Outcomes three.1. Comparison of Full Moles versus Postmolar Choriocarcinoma three.1.1. Clinical Qualities The clinical qualities of individuals having a diagnosis of total mole and/or postmolar choriocarcinoma are presented in Table 1. As expected, many of the postmolar choriocarcinoma patients displayed low-risk disease (i.e., FIGO score six) limited for the pelvis (i.e., FIGO stage I or II), and were treated through monochemotherapy or surgery.Biomedicines 2021, 9,five ofTable 1. Clinical traits of individuals with total mole and/or postmolar choriocarcinoma. Comprehensive Mole n = 14 Age (imply, range), y Serum hCG ahead of D C FIGO score (median, range) hCG at treatment initiation (median, range); IU/L Larger tumor size five cm (n) FIGO stage (n) I II III First-line remedy (n) Monochemotherapy (methotrexate) Polychemotherapy (EMA-CO) Surgery (hysterectomy) 37 (255) Postmolar Choriocarcinoma n = 17 35 (265) 3 (0) 19,098 (73901,938) 3 14 1 2 9 5hCG, human chorionic gonadotropin; IU/L, international units/liter; D C, dilatation and curettage; FIGO, F ation Internationale des Gyn ologues et Obst riciens; EMA-CO, etoposide, methotrexate and actinomycinD alternated weekly with cyclophosphamide and vincristine.three.1.2. Differential Gene Expression involving Total Mole and Postmolar Choriocarcinoma The comparison involving transcriptomic profiles of complete mole and postmolar choriocarcinoma samples identified 33 differentially expre.
Ment simulations. below fast cooling can be a incredibly successful and practical experimental method.2.The behavior
Ment simulations. below fast cooling can be a incredibly successful and practical experimental method.2.The behavior of transformation plasticity is crucial to predict component distortionAuthor Contributions: Brequinar Data Sheet Conceptualization, D.J. and Y.C.; Methodology, D.J. improveSoftware, X.L.; and residual Balovaptan Data Sheet stresses soon after carburizing and quenching and to and X.L.; the accuracy Validation, X.L. and D.J.;simulations. of heat therapy Formal evaluation, D.J., X.L., F.H. and H.L.; Investigation, D.J. and X.L.; Information curation, D.J., J.C., S.W. and X.L.; Writing, D.J. and X.L.; Review and editing, D.J. and J.C.; Visualization D.J.; Supervision, D.J.; Project management, D.J. and Y.C.; Funding acquisition, D.J. All authors have study and agreed to the published version of your manuscript. Funding: This investigation was funded by National Crucial R D System of China (2018YEE0207000). Institutional Overview Board Statement: Not applicable.Coatings 2021, 11,14 ofInformed Consent Statement: Not applicable. Information Availability Statement: The information presented in this study are readily available on request in the corresponding author. Conflicts of Interest: The authors declare no conflict of interest.
coatingsArticleInfluence of Voltage Sags on the Continuity from the Operation and Lifespan of Single-Phase Industrial RobotsGrzegorz Putynkowski 1, , Krzysztof Wony 1 , Elzbieta Szychta two and Leszek Szychta 2 zCBRTP S.A. Study and Improvement Center of Technology for Market, Warynskiego 3A, 00-645 Warsaw, Poland; [email protected] Faculty of Telecommunications, Personal computer Science and Electrical Engineering, UTP University of Science and Technology, al. prof. S. Kaliskiego 7, 85-796 Bydgoszcz, Poland; [email protected] (E.S.); [email protected] (L.S.) Correspondence: [email protected]: As a consequence of the enhance inside the quantity of automated processes that employ industrial robots (in particular in industrial and laboratory environments, like vacuum systems), and also the resulting enhance in the number of unresolved service requests, the purpose in the authors' analysis was to confirm the occurrence of disturbances inside the form of voltage sags which are not recorded by automation systems and which result in the destruction of robots or their gear in places defined by the characteristics of ITIC/SEMI F47 and CBEMA as becoming absolutely free from such disturbances. The article also describes the environmental classification of robots by their method functionalities/features, and recommends equipment that's capable to compensate for these disturbances. Such a classification strategy is usually a fantastic tool for building an exploitation culture and help the conscious choice of electrical gear in robotised systems susceptible to disturbances (e.g., robots in load-lock in vacuum environment).Citation: Putynkowski, G.; Wony, z K.; Szychta, E.; Szychta, L. Influence of Voltage Sags around the Continuity on the Operation and Lifespan of Single-Phase Industrial Robots. Coatings 2021, 11, 1229. https:// doi.org/10.3390/coatings11101229 Academic Editor: Ajay Vikram Singh Received: ten August 2021 Accepted: 28 September 2021 Published: 9 OctoberKeywords: robots destruction; electromagnetic compatibility; resistance of electrical gear; sag; vacuum environment1. Introduction As part of their investigation and development perform, the authors sought answers towards the question of how voltage sags influence the continuous operation and lifespan of single-phase industrial robots using a lifting.
On-Woog Chung 4 , Se-Hyun Chang 2 , Jae-Kwon Kim two , Dai-Jin Kim 5
On-Woog Chung 4 , Se-Hyun Chang 2 , Jae-Kwon Kim two , Dai-Jin Kim 5 and In-Young Choi two, Division of Biomedicine Health Sciences, The Sarpogrelate-d3 Epigenetic Reader Domain Cathlic University of Korea, Seoul 06591, Korea; [email protected] (K.-H.K.); [email protected] (W.C.); [email protected] (S.-J.K.) Department of Healthcare Informatics, College of Medicine, The Cathlic University of Korea, Seoul 06591, Korea; [email protected] (S.-H.C.); [email protected] (J.-K.K.) Department of Ophthalmology, Yeouido St. Mary's Hospital, The Cathlic University of Korea, Seoul 06591, Korea; [email protected] Division of Ophthalmology and Visual Science, St. Vincent's Hospital, College of Medicine, The Cathlic University of Korea, Seoul 06591, Korea; [email protected] Department of Psychiatry, Seoul St. Mary's Hospital, College of Medicine, The Cathlic University of Korea, Seoul 06591, Korea; [email protected] Correspondence: [email protected]: Kim, K.-H.; Choi, W.; Ko, S.-J.; Chang, D.-J.; Chung, Y.-W.; Chang, S.-H.; Kim, J.-K.; Kim, D.-J.; Choi, I.-Y. Multi-Center Healthcare Information High-quality Measurement Model and Assessment Making use of OMOP CDM. Appl. Sci. 2021, 11, 9188. https:// doi.org/10.3390/app11199188 Academic Editor: Pentti Nieminen Received: 12 July 2021 Accepted: 30 September 2021 Published: two OctoberAbstract: Healthcare data has economic value and is evaluated as such. Therefore, it attracted international attention from observational and clinical studies alike. Lately, the significance of information high-quality study emerged in healthcare data study. A variety of studies are getting performed on this subject. In this study, we propose a DQ4HEALTH model that may be applied to healthcare when Phortress Biological Activity reviewing current information good quality literature. The model consists of 5 dimensions and 415 validation rules. The four evaluation indicators consist of the net pass price (NPR), weighted pass rate (WPR), net dimensional pass rate (NDPR), and weighted dimensional pass price (WDPR). They were used to evaluate the Observational Healthcare Outcomes Partnership Common Data Model (OMOP CDM) at three healthcare institutions. These indicators identify variations in information high quality between the institutions. The NPRs in the three institutions (A, B, and C) were 96.58 , 90.08 , and 90.87 , respectively, and also the WPR was 98.52 , 94.26 , and 94.81 , respectively. Within the high quality evaluation from the dimensions, the consistency was 70.06 of your total error information. The WDPRs had been 98.22 , 94.74 , and 95.05 for institutions A, B, and C, respectively. This study presented indices for comparing excellent evaluation models and high-quality within the healthcare field. Applying these indices, healthcare institutions can evaluate the high-quality of their data and suggest practical directions for decreasing errors. Key phrases: healthcare data; OMOP CDM; multisite study; data top quality assessmentPublisher's Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.1. Introduction Healthcare information is evaluated as information with financial worth; subsequently, it attracts worldwide consideration from observational studies and clinical studies alike [1]. Healthcare information is often utilized remarkably swiftly, as a result of its large information set, continuity more than time, and timely availability. Regardless of this possible, it remains difficult to analyze and integrate multicenter data as a consequence of skepticism amongst healthcare centers and distinct data structures of electronic wellness record (EHR) systems [41]. To overcome this, the recent introductio.
T, the efficiency of absorption of lysine by sows and placental lysine transfer to gilts
T, the efficiency of absorption of lysine by sows and placental lysine transfer to gilts in the course of their late fetal development could possibly be a factor. Further investigation in this region is required, as lysine levels at 24 h postnatal were also positively connected to the fraction of newly synthesized DNA and the fractional synthetic price of DNA in mammary parenchymal tissue over the initial seven days postnatal. In the amount of the cell, nutrients, such as amino acids, regulate gene expression [24]. The mTORC1 signaling pathway in cells functions to integrate nutrient availability, development element signaling and developmental cues to regulate development [25]. The production of proteins, lipids and nucleotides need to increase for cells to develop and divide, although catabolic pathways for instance autophagy have to be suppressed. mTORC1 regulates all of these processes [25]. Amino acids and constructive cellular power status activate mTORC1, whereas lack of amino acids or energy inhibits its activity [26]. As a result, the association of lysine together with the total amount of DNA synthesized and DNA synthetic fractional synthetic rate probably reflects that it is indicative of nutrient-amino acid availability which can be utilised for cellular growth, and in certain, nucleotide synthesis. The physique does not retailer amino acids, so muscle protein is mobilized to produce absolutely free amino acids [24]. Protein undernutrition decreases the plasma amount of most important amino acids and causes adjustments in physiological functions, using a primary consequence of feeding a low protein eating plan resulting in the inhibition of growth [24]. The reduced levels of essential amino acids and reduced growth of COL10 gilts relative to COL20 animals likely reflect adaptations of COL10 animals towards the undernutrition they seasoned over the very first 24 h in the experiment. In addition, decrease in COL10 animals, there have been numerous non-essential amino acids, such as glutamine. For maximal growth overall performance, pigs demand dietary glutamine [27]. Research of neonatal pigs identified that nearly all glutamate and glutamine feed was metabolized by the gut, to ensure that glutamate and glutamine within the bodyAnimals 2021, 11,17 ofmust derive nearly completely from synthesis de novo [28]. Glutamine and glutamate are precursors and solutions of one another, with reactions catalyzed by glutamine synthetase and glutaminase. Circulating glutamate levels appear to become resistant to significant variations, with levels somewhat constant in experimental manipulations of diet plan and energy [29]. Component of this persistence can be as a result of sensitivity of hepatic glutaminase to metabolic state and its transcriptional stimulation induced by starvation. Meanwhile, there is certainly small effect of metabolic state on glutamine synthetase [29]. This might clarify the significantly reduce levels of glutamine in COL10 versus COL20 animals. In addition, though seemingly counterintuitive, the negative partnership involving glutamate and PEA may perhaps reflect that reduce power CC 122 Technical Information inside the postnatal environment negatively impacts mammary epithelial expansion. Inside the present study, the effect of returning D-Glutamic acid Epigenetic Reader Domain piglets for the birth litter after 24 h of bottle feeding was not controlled, aside from by matching treatments by litter. Differences in milk composition in between sows and competitors in between piglets could influence developmental trajectory inside the mammary tissue. Furthermore, this study didn't look at other bioactive variables in colostrum, like fatty acids or hormones. Future research aiming to understand the plan.
HomeT, the efficiency of absorption of lysine by sows and placental lysine transfer to giltsT, the efficiency of absorption of lysine by sows and placental lysine transfer to gilts


'What is life, if full of care we have no time to stand and stare?' So said Welsh poet W H Davies – and it's a good motto for gardeners. Take time out to simply enjoy being in the garden you've so lovingly created.
Seating in the garden in Trowbridge - Wiltshire slows the pace, providing a spot to pause and take in the view, and there's a great range of benches and chairs in our garden centre. Here are just some of the designs.
Formal wooden seats: including the ever-popular Lutyens bench, these well-crafted early 20th century designs look fabulous in country gardens.
Wrought-iron: a Gothic design popular in the late 18th and early 19th centuries, with ornate backs and scrolled arms, these look wonderful in Victorian-style gardens.
Contemporary style: clean lines, minimalist shapes and cool colours mark out modernist benches and chairs in sleek wood or moulded plastic - perfect for chic city gardens.
Tree seats: built around the trunk, these octagonal benches enhance the tree as well giving you views around the garden.
Adirondack chairs: American-designed wooden chairs made for comfort, available in natural teak or painted.
Please ask the staff in our Trowbridge - Wiltshire garden centre for more information and advice about choosing chairs and benches for your garden.


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NBCD
Statement_NBCD_Englisch
Statement on the "Interchangeability of drugs with a complex active substance composition"
The non-biological complex drugs (NBCD) consist of four drug groups: the low-molecular-weight heparins, the glatiramoids, the iron carbohydrate complexes and the liposomal parenterals (e.g. containing the active substance doxorubicin). They all share the common feature of being drugs with a complex composition. As they also include the low-molecular-weight heparins, however, which are biological in origin, the term "non-biological complex drug" is a legitimate subject for debate. None of the products is of biotechnological origin (i.e. a biological), however, which is to be conveyed by the internationally introduced name "NBCD".
In principle, all NBCDs differ very significantly from drugs with small, chemically defined molecules, in that:
they consist of a range of very similar complex components rather than having a unified molecular structure,
the total mixture of similar molecules is to be considered as "the active substance",
it has not yet been possible to characterize the complex features by means of physico-chemical analyses,
a consistent, carefully monitored manufacturing process is essential for ensuring the product's uniformity and reproducibility and
the clinical significance of any differences in the complex product features, such as immunogenicity, is largely not or only partially understood.
This very complex molecular and/or product structure makes it practically impossible to develop generic alternatives, i.e. products with an identical molecular composition. Instead, with these drugs, each product's composition is determined by its special manufacturing process ("the process is the product"). To this extent, distinguishing this group from those drugs with a chemically defined composition is not only meaningful but also essential.
Apart from the complexity of their composition, the various NBCD drugs have no immediate similarities. To date, therefore, there has been no uniform regulatory concept for them. The low-molecular-weight heparins do constitute a special case, however, because their biological origin means that, in Europe, they are treated as biosimilars for regulatory purposes.
Due to their non-biological origin, the glatiramoids, iron carbohydrate complexes and liposomal parenterals cannot be correspondingly classified, despite the fact that their complex composition also precludes any generic development. Even using the most efficient, highly sensitive and selective analytical methods currently available, the products' molecular composition can only be insufficiently characterized. Of course, this applies in equal measure when comparing originator drugs with imitator (me-too) products, for which it is thus not possible to provide unequivocal confirmation of an identical composition. Such products can therefore only be classified as "similar". As a result, in contrast to the generics, an authorization that references another product based on proof of bioequivalence is definitely not acceptable in such cases. Instead, there must be a requirement for comprehensive pharmaceutical/analytical investigations and preclinical and clinical trials, equivalent to those seen during the development of biosimilars, comparing the originator drug in each case.
This fundamental appraisal applies not only to the preconditions for authorization in the European Union but also to the assessment of the "interchangeability" of the NBCD in the course of its therapeutic application. This aspect has been clearly regulated for biosimilars, as an aut-idem substitution is excluded in principle pursuant to section 129 subsection 2 of the German Social Security Code, Book V. This decision is substantiated by the complexity of the product composition, which ensures only "similar", but possibly not really identical, clinical efficacy (and safety). In addition, the clinical comparative studies are not generally designed to encompass a switch from one product to another during an ongoing treatment. This rule should be extended to the other NBCDs, which are to be similarly assessed in this regard.
Detailed analysis of specific NBCD features leads to the conclusion that, in view of their particular product features with their very complex composition in all cases, a simple authorization referencing another product, solely supported by evidence of pharmacokinetic bioequivalence based on a single ingredient, is definitely not acceptable. To ensure safety of treatment in such cases, clinical studies confirming efficacy and safety are essential and should always be performed in comparison to the originator drug (if necessary, supported by comprehensive pharmacodynamic investigations). In each case, it must be ensured that the comparable therapeutic effects for the me-too products can be confirmed with the aid of adequate clinical or paraclinical (e.g. medical imaging procedures) endpoints. It remains to be seen to what extent this will actually occur for the products in question. From the point of view of medical professionals, who ultimately have to deal with this problem in practice, it should also be ensured that the evidence obtained from these clinical studies is provided in a form that allows them to fulfil their responsibility of always providing their patients with an effective and safe drug therapy. In addition, it is important that the safety of me-too products continues to be observed and monitored during their therapeutic use in the form of post-authorization safety studies.
For those NBCDs used in the long-term therapy of a patient whose drug dosage has been carefully titrated, an aut-idem substitution can therefore – analogous to the biosimilars – not be recommended until confirmation of "therapeutic interchangeability" is available. Based on current scientific evidence, the German Pharmaceutical Association (Deutsche Pharmazeutische Gesellschaft [DPhG]) considers it advisable to include the NBCDs on the "List of medicinal products excluded from substitution" published by the Federal Joint Committee (Gemeinsamer Bundesausschuss), provided that, as biosimilars, they are not already excluded from substitution, as is the case with the low-molecular-weight heparins.
This statement was prepared on the basis of the results of a consultation of experts organized by the German Pharmaceutical Association [DPhG]) together with the House of Pharma & Healthcare, Frankfurt. The following members of the expert panel contributed to the preparation of the statement and support the recommendations formulated therein:
Prof. Dr. Susanne Alban, Kiel Prof. Dr. Stefan Laufer, Tübingen
Dr. Michael Binger, Wiesbaden Dr. Martin Lorenz, Frankfurt
Prof. Dr. Henning Blume, Oberursel Prof. Dr. Jochen Maas, Frankfurt
Prof. Dr. Wolfgang Brück, Göttingen Dr. Milan Novakovic, Berlin
Dr. Joachim Burschäpers, Frankfurt Prof. Dr. Friedemann Paul, Berlin
Prof. Dr. Theodor Dingermann, Frankfurt Dr. Otto-Quintus Russe, Frankfurt
Dr. Daniel Fendji, Berlin Prof. Dr. Manfred Schubert-Zsilavecz, Frankfurt
Prof. Dr. Sebastian Harder, Frankfurt Prof. Dr. Fritz Sörgel, Heroldsberg
Prof. Dr. Eva Herrmann, Frankfurt Dr. Gerhard Tischler, Berlin
Lothar Jungbluth, Obertreis Dr. Christian Ude, Darmstadt
Prof. Dr. Michael Lämmerhofer, Tübingen Dr. Dagmar Walluf-Blume, Berlin

redpajama_set_name: RedPajamaCommonCrawl


What is the exact path that you have for Flora 3 at the moment?
where do i put the Flora 3 download? i placed the install directory into the OMSI 2 directory although for some reason Yorkshire map claims the assets are not there.
When you chose the place to install it on the wizard did put it in \OMSI 2 or something else? Because I installed it directly into the iomex folder and had to do some rearranging as it's set up in such a way that you just place it in the main OMSI directory and it sorts itself out.


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Home News BILLY IDOL, GRINSPOON, ESKIMO JOE just some of the Superstars to set the tone for Summer at AO Live Stage 2020
BILLY IDOL, GRINSPOON, ESKIMO JOE just some of the Superstars to set the tone for Summer at AO Live Stage 2020
A stellar line-up of international superstars and home grown heroes is set to perform at the AO Live Stage over 15 days of music at Australian Open 2020.
Presented in association with Mushroom Events, this exciting roster of artists boasts 16 ARIA nominations between them, promising two stunning weeks of music for fans at the AO Live Stage at Middle Terrace.
Six major international acts plus 23 Australian artists are confirmed, with more to be announced in the coming months.
Example (UK), Billy Idol (UK), Bastille (UK), Max Frost (USA) and Broods (NZ) will bring eclectic international flair, offering fans everything from hip hop, dance, indie pop and electropop to classic hard rock, making the AO Live Stage a 'must-do' in 2020.
Bastille will make a triumphant return to the AO on the back of massive success with mega tunes such as 'Pompeii' and recent Marshmello collaboration 'Happier'. With more than eight million album sales and global streams over the 6.5 billion mark, Bastille is one of the most streamed acts on the planet.
Idol's place in rock & roll history is one of legend. 'White Wedding', 'Dancing With Myself', 'Rebel Yell', 'Flesh For Fantasy', 'Eyes Without A Face'… with a huge list of global hit singles to his name including 8 x US Top 20 hits, rock icon Billy Idol needs little introduction to fans and will delight AO crowds.
Cub Sport, Matt Corby and Ziggy Alberts will entertain crowds with their smooth vocals and acoustic tunes while Hot Dub Time Machine, Hayden James and Example will appeal to the DJ and EDM scene.
Kate Miller-Heidke, Broods and Seeker Lover Keeper will appeal to pop aficionados, and Billy Idol, Eskimo Joe and Grinspoon will charm the most nostalgic music fan.
Award winning singer songwriter Kate Miller-Heidke traverses the worlds of indie-pop, folk and opera. She is the only artist in history to perform at the New York Metropolitan Opera, the Eurovision Song Contest and Coachella, and the AO Live Stage.
Australia's favourite sister-act, The Veronicas, set to appear on Thursday 23 January, will be supported by up and coming artists Japanese Wallpaper and Kian; whose hit song 'Waiting' made its way quickly to the top of the Australian music charts this year.
"The AO Live Stage continues to go from strength to strength and the 2020 line up is the biggest and best ever," Australian Open Tournament Director, Crag Tiley said.
"As well as being Australia's biggest sporting event, the AO Live Stage has become one of the country's biggest music festivals. This has helped us grow our event and introduce the Australian Open to new fans who now have even more spectacular entertainment choices, both on and off the court."
CEO of Mushroom Events Michael Gudinski says "After the unprecedented success of the 2019 AO Live Stage and the amazing growth of the Australian Open, the music component at the AO has cemented itself as a must play summer concert date.
"Attractive to International artists plus the vast array of great Australian, established and up & coming talent, the diversity of the line-up over the two-week period means there is absolutely something for everyone. Our team at Mushroom Events continue to work alongside the Australian Open to produce an incredible varied line-up for tennis & music fans."
The spectacular shade structure which was a hit at the AO Live Stage this year, will return for 2020, and along with the popular giant misting fans, will help fans keep their cool while getting their groove on.
Fans can access AO Live Stage with either an Australian Open Ground Pass ($49) or stadium ticket.
Please note: All patrons aged under 18 must be accompanied by a responsible adult. Photo ID is required for entry. For more information on these terms and conditions please click here.
AO LIVE STAGE
JANUARY & FEBRUARY 2020
AO GIRLS DAY OUT
Sun 19 Jan | Jessica Mauboy with special guests Montaigne and Lily Papas
Tickets on sale on Wed 20 Nov – $5 for children and $20 for adults at ticketmaster.com.au
THE AO STAGE LINEUP SO FAR:
Mon 20 Jan | Cub Sport with special guest: Hatchie
Tue 21 Jan | To be announced…
Wed 22 Jan | Lime Cordiale with special guest: Ruby Fields
Thu 23 Jan | The Veronicas with specials guests: Japanese Wallpaper Kian
Fri 24 Jan | Grinspoon with special guests: Eskimo Joe
Sat 25 Jan | Hot Dub Time Machine with special guest: Example (UK) (18+ only)
Sun 26 Jan | To be announced…
Mon 27 Jan | Kate Miller-Heidke with special guests: Seeker Lover Keeper
Tue 28 Jan | Broods (NZ) with special guest: George Alice
Wed 29 Jan | Billy Idol (UK) with special guests: The Delta Riggs
Thu 30 Jan | Matt Corby with special guest: Charlie Collins
Fri 31 Jan | Hayden James with special guests: Running Touch
Sat 1 Feb | Bastille (UK) with special guest: Max Frost (USA)
Sun 2 Feb | Ziggy Alberts with special guest: Fergus James
Australian Open 2020, presented by Kia Motors in association with Luzhou Laojiao and Rolex, will take place at Melbourne Park from 20 January to 2 February. Australian Open tickets including ground passes, which allow access to Melbourne Arena, are on sale via ticketmaster.com.au.
Visit ausopen.com for more information.
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Rheumatologist Sherry Wu is also trained in traditional Chinese medicine.
Growing up in northeast India, Renu Sinha recalls her family using therapies from Western and Eastern traditions to stay healthy. They would meditate and practice yoga, and she recalls getting ayurvedic treatment, an ancient Indian healing system. When she was sick, her mother would give her ginger tea sprinkled with turmeric, a spice long used in Asian cuisine that's recently been recognized for its range of health benefits.
After moving to the U.S. and graduating from medical school, Sinha took a job teaching at the University of Arizona's College of Medicine. There, she says, therapies from various traditions were similarly blended. Andrew Weil, a physician who has popularized complementary and alternative treatments, is on the faculty.
But when she moved to Spokane, where she works a surgeon specializing in thyroid surgery, she says she didn't find the same acceptance of nontraditional medicine.
Now Sinha, and a group of like-minded health care providers, are hoping to change the culture of medical care in Spokane. Specifically, Sinha wants nontraditional therapies, including Tai Chi, acupuncture, special diets, chiropractic and other unconventional treatments to become as mainstream in Spokane as X-rays and prescriptions.
"If we educate and break down barriers, we can improve access and opportunities for wellness, and improve discussions between health care providers on how we can integrate traditional and nontraditional approaches," says Sinha.
Since June, the group of health care professionals (about half are medical doctors) called "Healing Spokane" has been meeting nearly every month to exchange ideas and strategies on how to make better use of nontraditional therapies. They're also planning on holding forums intended to educate the public on the benefits of nontraditional therapies for common ailments; the first was a back pain forum in September.
Sinha says that research is increasingly confirming the effectiveness of many treatments that were once dismissed by mainstream medicine. For instance, she points to research published in medical journals showing that acupuncture, yoga, Tai Chi, massage therapy and relaxation techniques have the potential to help treat and manage pain. She also says that some of the these treatments are being embraced by the Duke University School of Medicine and the Mayo Clinic.
They're also being embraced by patients. In 2012, the National Health Interview Survey found that 59 million Americans spent $30 billion on alternative care.
However, despite growing evidence and a clear interest from patients, there are barriers to making these treatments more widely accepted in places like Spokane.
"We're a pill-popping society," says Catherine Anne Lee, a rheumatologist involved with Healing Spokane, who became interested in complementary medicines after her patients kept seeking them.
Patients and medical professionals, she says, are accustomed to looking for quick fixes for ailments. But taking medications or having an invasive surgery can carry side effects, says Lee, and a lifestyle change that incorporates treatments such as massage therapy and chiropractic work can lead to lasting health.
"I think medications can only take you so far," says Lee, who notes she's had patients who switch to low-sugar, low-glucose or anti-inflammatory diets, and it's made a significant difference in their health.
Lee says that one obstacle to having complementary therapies used more widely is that insurance plans differ in terms of what types of treatments they'll cover. And, she says, if patients have to pay out of pocket for an additional complementary treatment, they might just skip it.
Lee and Sinha, both specialists, say they have more time to discuss alternative or complementary therapies with their patients. They point out that primary care doctors are typically pressed for time and aren't able to talk with patients about holistic approaches to their health that include diet changes, stressors and therapies that might be helpful.
"You can't do that in 10 minutes," says Lee.
Sherry Wu, a local physician who grew up in China, decided to go back to school for a master's in traditional Chinese medicine after getting her medical doctorate. Now, Wu, who is also involved with Healing Spokane, offers acupuncture to help patients with pain relief. But she says that for many members of the public, nontraditional treatments still seem "mysterious or odd."
Lee says Healing Spokane provides an opportunity for simply meeting with other health care professionals who have a similar philosophy, noting it is helpful for them to swap ideas. She says they all have a goal of maintaining patients' health and doing more than just responding to diseases, which she says have become the focus of traditional Western medicine.
In the future, Sinha says she hopes to get nonprofit status for Healing Spokane and further expand its outreach efforts to the city's medical community and local patients. She thinks the message will eventually take hold in Spokane the same way it has in other communities.


Posted on 03/14/2018 by Lesli W.
After a blizzardy day, the sun decided to make itself known again. This photo says something aspirational to me. Maybe it's the light, tap-dancing on the storm's receding waves. Maybe it's the idea of flight; the allure of escaping, by wing, to warmer climes. The touch of warm sun on cool earth, like spring's teasing foreplay, as dormant life finds new purchase and scrabbles for its footing amidst a slippery, snow-covered terra (not-so) firma. Or it's just seagulls, doing what they do.
A blizzard this week, and who knows what the rest of March will bring (of late, it seems to come in like a lion and go out like a pissed-off yeti rather than lamb), it will be weeks before we feel true warmth here in New England. Until then, I'll watch and wait, planning the next tropical adventure, a continuation of Year of Africa and a land-locked mermaid's dream; my own spirits warming with the increasing daylight.


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"Prime Meridian" and Its Many Marses
Prime Meridian by Silvia Moreno-Garcia
Silvia Moreno-Garcia's "Prime Meridian" is about Mars, though not the red planet nor the Roman god of war. Instead, this story features a black-and-white Mars decorated with cheap studio effects, another Mars that exists only as a bond between a young couple that cannot survive the chasm of their inequity of wealth, and a third Mars that calls to Amelia's soul from a billboard. Each Mars drives the plot and situates the story in terms of real world history, culture, and the history of science fiction.
In Moreno-Garcia's near future, Mexico City's wealthy exploit the despair of vast masses of disadvantaged youth in a hyper version of today's gig economy. Amelia, our protagonist, abandoned her studies of urban agriculture to care for her ailing, dying mother and is saddled with ferrying her sister's children around in the bargain. Amelia calls herself a freelancer on her CV, noting it is a "euphemism for unemployed." Her bleak possibilities recall Birdie's options in Disch's "Problems in Creativeness," but what is at stake for Amelia is not the right of procreation but merely basic survival. At the story's inception Amelia's current gig is Friendrr, where lonely rich people pay her to be their friend for an hour, and her sole client is Lucía, once a "middling starlet" in 1960s Mexican cinema. From Amelia's description, comparing her to "the core of a dead tree," her house "artificial, too-calculated, too overdone" and her hospitality as generous as an infrequent dish of pomegranate seeds and glass of mineral water, our heroine clearly despises the ex-actress.
They watch Lucía's second movie, dated 1965, which is set on Mars. At one point, Lucía says, "The real Mars is bland compared to the one the set designer imagined." Amelia volunteers to the actress how she wants to go to the colonies. Amelia reinforces her wish in later conversations as well, but Moreno-Garcia underplays these exchanges, so the payoff at the story's end is unexpected (at least to me it was.)
The author plants the story in the real world by amply seasoning the tale with Mexican culture. Lucía's casona, for example, is plausibly placed in Coyoacán, the neighborhood where Frida Kahlo lived, where she was jailed after Leon Trotsky's assassination. A wealthy ex-actress "who got lucky and married a filthy rich politician" who lived there certainly might decorate her home with colorful talaveras. Moreno-Garcia adds other recognizable elements—pulquerias, champurrado, esquite, rebozos, huipiles, and tinacos—but in Amelia's world the pulquerias are being replaced by fusion restaurants, the huipiles are designer brands, and the rebozos are made in China. "Folkloric bullshit," our protagonist opines, but these references illustrate the Swanwickian large, philosophical question of the story, the postcolonial effects upon the Mexican poor. The rich are free to enjoy Nahuan tamazcal in Peru, while the poor scrape by in purposeless hand-to-mouth existence.
Moreno-Garcia also reinforces her setting by adding real world references. Alejandro Jodorowsky and Luis Buñuel were active in Mexico's film industry. In fact, Buñuel's film Fando y Lis caused a riot in Acapulco. The producer of Lucía's film, however, Nahum (Eduard) Landmann, is actually an inside joke, a reference to the "legendary founder" of Moreno-Garcia and Lavie Tidhar's (who wrote the novella's introduction) literary journal, The Jewish Mexican Literary Review (Tidhar).
In any case, Stanley Weinbaum ("A Martian Odyssey") and A.E. Van Vogt ("The Enchanted Village") would recognize Lucía's Mars, because it is not Mars but "Mars. The moons are paper and the stars are tinfoil. So, it is possible to step forward [without a spacesuit]." The Mars of Lucías heyday is only for stories. It is the same Mars early SF stories were set, one for SF but not for science.
The Mars of the colonies is the same of the tender couple's dreams, however rich Elías is bound to Earth. A creature of privilege, when he ghosts Ameli, he blames his father. Once he finds her on Friendrr, he transforms her into a willing, if unenthusiastic, whore. When she catches him in his stalking lie, he expresses regret saying, "I should have gone to New Panyu [a Martian colony] with you… My dad wouldn't give me the money, but I should have done something." Amelia compassionately offers him another chance, but at the story's end, when Amelia announces her get-out-of-squalor-free card (Lucía's gift), he chooses instead a boring life with Anastasia, the meat exhibition virtuoso. ("No offense, Amelia, but what do you know about art?")
Moreno-Garcia's story of income discrepancy is well founded in Mexico's current conditions. The author just tightened the screws already present a few more turns. According to its public site, Mexico City is the "eighth-richest urban agglomeration" and produces over a fifth of Mexico's wealth, but its distribution of income is sinfully unequal. In 2010, Reyes, Teruel, and Lopez determined the truth was worse than the official numbers, demonstrating "the richest 1% of the population receives the same amount of income as the other 90%." These people are rich enough to pay poor workers for an hour of cuddling, friendship, or even less savory duties.
Perhaps Elías did once dream of a life with Amelia in New Panyu, but when asked to choose, he chose the dream he already lives. "Cut the shit," he tells her. "Come with me to Monterrey. I'll rent a place for you there. I'll pay your expenses." He is offering her a long-term constant side gig until he gets bored again and ghosts her. Amelia, who despite misgivings of being a bad friend (though she cleans out her life savings for Pili), deserves more, and Lucia's "shaky words… scrawled with a black felt pen" leave her no confusion. "Do what you want, Amelia," they say. The gift transforms Amelia into the woman on the billboard, the "confident" girl who "knew things" (in numerous asides she recites Martian facts) and "knew people" (enough of them at least.) Through Lucía's gift, she is ready for her final Mars, her exit from Mexico City. She may struggle, but after Mexico City's grind, she is ready. The story's satisfying conclusion, though the gift is unexpected, feels earned.
On Silvia Moreno-Garcia's patron page, she describes her work as "magic realism, horror, fantasy and noir." She also won a World Fantasy Award as editor for She Walks in Shadows. "Prime Meridian," set in a near-future Mexico City with musical tattoos and "dancing, singing, 3D hologram[s] [of] teenage avatar[s] in a skimpy French maid's outfit who… call you "Master" and wake you up in the morning with a song" recalls Williamson's "With Folded Hands" perfect mechanicals, albeit with spicy upgrades. Read as a tale of a collection of Marses, it fits Zelazny's SF definition too, but the story itself feels more like literary fiction. Moreno-Garcia adds a parallel aside, told in script form, which draws attention to the prose, and despite the protagonist's enormous efforts to change her destiny, she is ever the target rather than the instigator of events. In any case, this is a thought-provoking story by a versatile author (Zombies!) and a fulfilling end to a semester of exploration.
#Goodreads #Review #SFF #SpeculativeFiction
Labels: #Goodreads #Review #SFF #SpeculativeFiction


text:
Prince Arthur
The Royal Mile
PS Kingswear Castle
A Personal Tribute
John Megoran
Former skipper John Megoran shares his archive of images of Kingswear Castle
Kingswear Castle is one of a number of smaller paddle steamers built in the nineteenth and early twentieth centuries to provide transport and excursions along some of Britain's most beautiful rivers. One of three identical sisters, she was the last to be built for service on the River Dart and also the last to be withdrawn, ending her first career in September 1965.
Fortunately, she did not follow other paddle steamers into the scrapyard but lingered on, first on the Isle of Wight and then on the Medway, where a sort of restoration began, which culminated in her return to full passenger service in 1985.
Written by John Megoran, her manager and captain during the Medway and Thames years, this book chronicles Kingswear Castle's story – including how revenue from her new operational life sailing in an area bounded by Putney, London, Southend, Whitstable, Herne Bay, Chatham and Aylesford, plus grants and donations, financed further major restoration, including the provision of a new coal-fired boiler, sponsons, paddle boxes, fiddley, decks, hull re-plating and much more.
Returned to her old home waters in 2013, Kingswear Castle now offers a new generation the joys and delights of sailing on the River Dart aboard a traditional steamship.
British Paddle Steamers
PaperbackJohn Megoran
Bell's Comet
PaperbackP. J. G. Ransom
Medway & Swale Shipping Through Time
PaperbackGeoff Lunn
Industrial Locomotives & Railways of the South and West England
PaperbackGordon Edgar
Traction Engines
PaperbackAnthony Coulls


text:
Perth Glory v Gold Coast United - Preview
Glory's amazing season continues! Can Gold Coast United stop Glory from marching on? Will Robbie Fowler strike again…?
Perth Glory v Gold Coast United Sunday 12th September 3:00pm nib Stadium
Glory-s amazing season continues! Can Gold Coast United stop Glory from marching on? Will Robbie Fowler strike again…?
There-s a real feeling of momentum about Perth right now. Backed by a big and vocal crowd at nib Stadium last week, Glory returned to the top of the ladder with a hard-fought victory over Wellington.
Now, with their second home game in a row, The Shed are sure to be in the strong voice we have come to expect from them as they see an opportunity for three more points against winless Gold Coast United.
In aiming for their eighth undefeated match in a row, Glory will be looking to create the longest streak without losing since Melbourne went for eight unbeaten matches in 2008.
Last week, it was the marquee men that did the job as Glory continued their unbeaten start to the Hyundai A-League 2010/11 season. Mile Sterjovski's fifth-minute strike got the ball rolling before Robbie Fowler's second-half goal sealed the win.
Having broken his Perth duck the previous week with an injury-time penalty against Melbourne Heart, it seemed almost inevitable that the goals would start to flow from the former Liverpool legend. With two crucial strikes in the last two matches, the veteran-s hunger for goals is clearly as strong as ever. Not good news for Gold Coast United!
Having already faced two weekend breaks, United have experienced a stuttering start to their Hyundai A-League 2010/11 season. With two draws and one defeat from their three weeks of action so far, it feels like their campaign has yet to really get under way.
However, a decent goalless derby draw at home to fierce rivals Brisbane and a fantastic point in the harshest of conditions in Wellington suggest that United will be no pushovers for Glory.
As Shane Smeltz-s 'will-he-won-t he- transfer saga finally came to end when he signed for Turkish Super League club Genclerbirligi SK last week, United moved swiftly to replace him by bringing in Qantas Socceroo Bruce Djite until the end of the Hyundia A-League 2010/11 season.
The former Adelaide United striker is set to make his debut against Glory, and will be looking to start his second spell in Australia with a bang as Gold Coast seek their first win of the season.
It-s the tale of two strikers at nib Stadium this Sunday. Will it be Fowler or Djite that comes out on top? It-s time for The Shed to make some serious noise and ensure that it-s a golden afternoon for Glory.
Tickets available Here.
Full squad information and match details will be available at www.a-league.com.au on Thursday.


Map to Kleberg OCD therapists.
What does therapy look like at Kleberg Center for OCD & Anxiety?
OCD Kleberg, Texas 75334. Obsessive Compulsive Disorder (OCD) is identified in pair of parts: fascinations and also compulsions. Fixations are unwanted and also intrusive thought and feelings or emotions that start to cause stress and also distress that interrupt daily jobs. In feedback to these thought and feelings or emotions the individual begins to take part in repeated actions that minimize the stress, called an obsessions or routines.
The obsession is used to counteract or counteract the stress. Although most sufferers recognize that their fascinations are irrational the compulsive actions really feels gratifying and also triggers the individual to experience a lot less restless and also distressed. About 1-2% from the standard populace struggles with OCD, a disorder that commonly provides in teenage years or very early maturity, however signs found in incredibly younger kids also. Signs and symptoms frequently flare-up during time periods from enhanced tension.
Many OCD sufferers carry out certainly not look for procedure, frequently mentioning emotions from pity or embarrassment concerning the nature from their fascinations and/or compulsions. Studies advise that OCD sufferers go in between 12 and 17 years off the onset from signs before obtaining procedure from an ERP (Visibility and also Response Deterrence) professional.
Obsessive-compulsive ailment (OCD) is a stress and anxiety ailment through which people possess unwanted and also repetitive thought and feelings, emotions, tips, experiences (fascinations), or actions that produce all of them feel steered to carry out something (compulsions). This impacts kids, children, teenagers and also grownups.
Commonly the individual executes the actions in order to get rid from the uncontrollable thought and feelings, however this only provides short-term comfort. Not executing the uncontrollable routines may cause excellent stress. A person's degree from OCD could be anywhere off mild to intense, however if intense and also left behind unattended, this may ruin an individual's capability to work at the office, at university or maybe to lead a relaxed existence in the home.|Obsessive-compulsive ailment (OCD) is a stress and anxiety ailment in which people possess unwanted and also repetitive thought and feelings, emotions, tips, experiences (fascinations), or actions that produce all of them feel steered to carry out something (compulsions).
A person's degree from OCD may be actually anywhere off mild to intense, however if intense and also left behind unattended, this may ruin an individual's capability to work at job, at university or even to lead a relaxed existence in the home.} If you are actually searching for help along with OCD therapy in Kleberg or for an Kleberg OCD specialist, these professionals supply OCD procedure and also obsessive compulsive disorder procedure. They include OCD counselors, OCD psycho therapists, OCD psychoanalysts and also OCD therapists in Kleberg They may assist with Kleberg OCD guidance, OCD signs, OCD kids, obsessive compulsive disorder, and also OCPD. Hair-pulling (trichotillomania) and also skin layer selecting (dematillomania), together pointed to as Physical body Focused Repeated Behaviors, are categorized as OCD-related disorders.
We also services Bobwyn OCD, Rylie OCD, Lawson OCD, Balch Springs OCD, Seagoville OCD, Hutchins OCD, Mesquite OCD, Patrick OCD, Wilmer OCD, Markout OCD. Please contact us if you have a child with OCD in any of these areas.
The gold specification, very most effective procedure from OCD is referred to as Direct exposure and also Response Deterrence (ERP). Therapy is especially significant for people who have actually cultivated ritualized, repeated actions including compulsions. ERP is a needed part from CBT for most stress health conditions, especially OCD. The pair of elements include direct exposures– encountering concerns in an organized, steady, and also deliberate way to evoke stress– and also feedback (or ritual) avoidance– definitely avoiding protection actions and also other avoidant approaches that only offer temporary decrease from signs however keep the pattern from stress and also avoidance in the long-term. Each elements are vital for effective ERP. Via the ERP procedure, the individual overcomes concerns, gains corrective info, and also re-trains the human brain to no more evoke a fight or trip response despite these "duds." Our counselors will certainly guide you to considerably deal with the situations and also thought and feelings that prompt your OCD while learning just how certainly not to respond along with routines, compulsions, reassurance finding or avoidance. Our experts likewise offer an "Extensive Outpatient Course" (IOP) for OCD sufferers in the event that where no available ERP professionals are in your geographical place, when companies are just certainly not conveniently obtainable, or given that symptom extent is also high for regular hospital therapy. The procedure is tailored to satisfy the degree from necessity, schedule, and also preparedness for change to attend to present signs and also acquire the individual to a higher degree from operating where more conventional hospital therapy could be the degree from care. The goal from an IOP is to full procedure along with 4-6 weeks and also for that reason commonly requires treatments back to support times, several hrs every day, and also at times over the weekend break.
Just what does therapy resemble at Kleberg Center for OCD & Stress and anxiety? A counselor will meet with you for an initial examination (your 1st consultation). In the course of the 1st session, you and also the specialist will certainly establish if the specialist is the most effective individual to supply the companies you must fulfill your targets. If both you and also the specialist determine to proceed functioning with each other in procedure, you will certainly review a therapy planning and also assess your development as you move on. If the specialist feels our experts are certainly not the appropriate provider, or you are certainly not a great match for the companies our experts supply, our experts will certainly let you know, and then assist you discover a service provider who might be a. much better match.


text:
Q: Drawing a chart with owc chartspace in userform vba excel I have a little problem with my owc chartspace, I would like to draw a chart like in the picture but my problem is that it draws only for one series I would like to draw it for the 1 the 2 and the 3 I don't know how to do this.
I have a listbox and a combobox, I select from the list box the 1,2,3 and I select from the combobx y or z such that x is fixed.
Then I put the data in plage(1) for x and plage(2) for y but the problem is that it works only for the first item I select from the listbox ( in this picture the "1" )
Could you tell what is wrong in my code?

the vba code for drawing the chart into the userform is:
      Private Sub drow()
                                                                                Dim i, k As Integer, x As Integer
          Dim j As Integer
          Dim Table(), Plage(2)
          Dim id As Integer

          id = 1

         Do While ComboBox.Value <> idi(id, 1)
           id = id + 1
          Loop

          For i = Cht.SeriesCollection.Count To 1 Step -1
             Cht.SeriesCollection.Delete i - 1
          Next i

              k = 1
           ReDim Table(ListBox.ListCount)

        For i = 0 To ListBox.ListCount - 1
          If ListBox.Selected(i) = True Then
             Table(k) = ListBox.List(i)
            k = k + 1
          End If
          Next i

    With Cht
    .HasLegend = True
     .Legend.Position = chLegendPositionBottom
         .HasTitle = True
        .Title.Caption = ComboBox.Text
       End With

  Cht.Type = C.chChartTypeColumnClustered3D

    With Cht
        'first serie
        .SeriesCollection.Add
        .SeriesCollection(0).Caption = sheet.Cells(2, 15 + id)
        .SeriesCollection(0).DataLabelsCollection.Add
        .SeriesCollection(0).DataLabelsCollection(0).Position = chLabelPositionCenter
        .SeriesCollection(0).DataLabelsCollection(0).Font.Color = RGB(255, 255, 255)

        .SeriesCollection.Add
        .SeriesCollection(1).Caption = sheet.Cells(2, 20)      .SeriesCollection(1).DataLabelsCollection.Add
        .SeriesCollection(1).DataLabelsCollection(0).Position = chLabelPositionCenter
        .SeriesCollection(1).DataLabelsCollection(0).Font.Color = RGB(255, 255, 255)

        .SetData C1.chDimCategories, C1.chDataLiteral, Table

        End With

   For j = 0 To ListBox.ListCount - 1
    If ListBox.Selected(j) = True Then

     Plage(1) = sheet.Cells(j + 3, 15 + id) 'the Xs
     Plage(2) = sheet.Cells(j + 3, 20) 'Les 'the Ys

      With Cht

        .SeriesCollection(0).SetData C1.chDimValues, C1.chDataLiteral, Plage(1)
        .SeriesCollection(1).SetData C1.chDimValues, C1.chDataLiteral, Plage(2)

      End With
    Erase Plage
   End If
  Next j

  End Sub

A: I am very new to the whole owc and VB thing and I am having some troubles myself, but have you tried using C1.chDimXValues and C1.chDimYValues instead of the chDimValues in the below statement:

.SeriesCollection(0).SetData
  C1.chDimValues, C1.chDataLiteral,
  Plage(1) .SeriesCollection(1).SetData
  C1.chDimValues, C1.chDataLiteral,
  Plage(2)

Sorry if this might sound trivial, I can see your coding skills are much more advanced than mine. Good luck!

redpajama_set_name: RedPajamaStackExchange


With Kyrie Irving's season over, the Boston Celtics don't look as scary as they once did. And since the Celtics are just about locked into the No. 2 seed, the No. 7 seed might actually look attractive to teams. Milwaukee could have moved into No. 7 on Thursday, but it lost to Brooklyn.
Utah's easy win over the Los Angeles Clippers put the Jazz on the brink of clinching. Minnesota hurt its cause with a loss to Denver and dropped to No. 8 in the Western Conference.
It's still seven teams alive in the race for the final five spots out West.
— Atlanta at Washington: The Wizards will try to end a three-game losing streak, but John Wall won't play.
— Chicago at Boston: Celtics' first game since the Irving-is-done news came out.
— Miami at New York: Win keeps Heat in the driver's seat for No. 6 seed and, possibly, a first-round matchup against LeBron James.
— New Orleans at Phoenix: Obviously, not a game the Pelicans can waste, not against a team with the NBA's worst record.


text:
Haute-Épine és un municipi francès, situat al departament de l'Oise i a la regió dels Alts de França. L'any 2007 tenia 288 habitants.

Demografia

Població
El 2007 la població de fet de Haute-Épine era de 288 persones. Hi havia 102 famílies de les quals 16 eren unipersonals (12 homes vivint sols i 4 dones vivint soles), 39 parelles sense fills, 43 parelles amb fills i 4 famílies monoparentals amb fills.

La població ha evolucionat segons el següent gràfic:

Habitants censats

Habitatges
El 2007 hi havia 112 habitatges, 100 eren l'habitatge principal de la família, 10 eren segones residències i 2 estaven desocupats. Tots els 112 habitatges eren cases. Dels 100 habitatges principals, 81 estaven ocupats pels seus propietaris, 17 estaven llogats i ocupats pels llogaters i 2 estaven cedits a títol gratuït; 3 tenien dues cambres, 14 en tenien tres, 28 en tenien quatre i 55 en tenien cinc o més. 90 habitatges disposaven pel capbaix d'una plaça de pàrquing. A 35 habitatges hi havia un automòbil i a 61 n'hi havia dos o més.

Piràmide de població
La piràmide de població per edats i sexe el 2009 era:

Economia
El 2007 la població en edat de treballar era de 178 persones, 131 eren actives i 47 eren inactives. De les 131 persones actives 122 estaven ocupades (69 homes i 53 dones) i 9 estaven aturades (2 homes i 7 dones). De les 47 persones inactives 15 estaven jubilades, 16 estaven estudiant i 16 estaven classificades com a «altres inactius».

Ingressos
El 2009 a Haute-Épine hi havia 98 unitats fiscals que integraven 282 persones, la mediana anual d'ingressos fiscals per persona era de 21.356 €.

Activitats econòmiques
Dels 2 establiments que hi havia el 2007, 1 era d'una empresa de fabricació d'altres productes industrials i 1 d'una empresa d'hostatgeria i restauració.

L'únic servei als particulars que hi havia el 2009 era un restaurant.

L'any 2000 a Haute-Épine hi havia 5 explotacions agrícoles.

Equipaments sanitaris i escolars
El 2009 hi havia una escola elemental integrada dins d'un grup escolar amb les comunes properes formant una escola dispersa.

Poblacions més properes
El següent diagrama mostra les poblacions més properes.

Referències

 Résumé statistique Fitxa resum de dades estadístiques de Haute-Épine a l'INSEE.
 Évolution et structure de la population Fitxa amb el detall de dades de Haute-Épine a l'INSEE
 France par commune  Dades detallades de tots els municipis de França accessibles a partir del mapa.

Municipis de l'Oise

redpajama_set_name: RedPajamaWikipedia


text:
using Microsoft.VisualStudio.TestTools.UnitTesting;

namespace LiteDB.Tests
{
    public class MyBsonFieldTestClass
    {
        [LiteMapper(FieldName = "MY-STRING")]
        public string MyString { get; set; }

        [LiteMapper]
        internal string MyInternalPropertySerializable { get; set; }

        [LiteMapper]
        private string MyPrivatePropertySerializable { get; set; }

        [LiteMapper]
        protected string MyProtectedPropertySerializable { get; set; }

        [LiteMapper(FieldName = "INTERNAL-PROPERTY")]
        internal string MyInternalPropertyNamed { get; set; }

        [LiteMapper(FieldName = "PRIVATE-PROPERTY")]
        private string MyPrivatePropertyNamed { get; set; }

        [LiteMapper(FieldName = "PROTECTED-PROPERTY")]
        protected string MyProtectedPropertyNamed { get; set; }

        internal string MyInternalPropertyNotSerializable { get; set; }
        private string MyPrivatePropertyNotSerializable { get; set; }
        protected string MyProtectedPropertyNotSerializable { get; set; }

        public void SetPrivateProperties(string str)
        {
            MyPrivatePropertyNamed = str + "Named";
            MyPrivatePropertySerializable = str + "Serializable";
            MyPrivatePropertyNotSerializable = str + "NotSerialisable";
        }

        public void SetProtectedProperties(string str)
        {
            MyProtectedPropertyNamed = str + "Named";
            MyProtectedPropertySerializable = str + "Serializable";
            MyProtectedPropertyNotSerializable = str + "NotSerialisable";
        }

        public string GetMyPrivatePropertySerializable()
        {
            return MyPrivatePropertySerializable;
        }

        public string GetMyProtectedPropertySerializable()
        {
            return MyProtectedPropertySerializable;
        }

        public string GetMyPrivatePropertyNamed()
        {
            return MyPrivatePropertyNamed;
        }

        public string GetMyProtectedPropertyNamed()
        {
            return MyProtectedPropertyNamed;
        }

        public string GetMyPrivatePropertyNotSerializable()
        {
            return MyPrivatePropertyNotSerializable;
        }

        public string GetMyProtectedPropertyNotSerializable()
        {
            return MyProtectedPropertyNotSerializable;
        }
    }

    [TestClass]
    public class BsonFieldTest
    {
        private MyBsonFieldTestClass CreateModel()
        {
            var c = new MyBsonFieldTestClass
            {
                MyString = "MyString",
                MyInternalPropertyNamed = "InternalPropertyNamed",
                MyInternalPropertyNotSerializable = "InternalPropertyNotSerializable",
                MyInternalPropertySerializable = "InternalPropertySerializable"
            };

            c.SetProtectedProperties("ProtectedProperties");
            c.SetPrivateProperties("PrivateProperty");

            return c;
        }

        [TestMethod]
        public void BsonField_Test()
        {
            var mapper = new BsonMapper();
            mapper.UseLowerCaseDelimiter('_');

            var obj = CreateModel();
            var doc = mapper.ToDocument(obj);

            var json = JsonSerializer.Serialize(doc, true);
            var nobj = mapper.ToObject<MyBsonFieldTestClass>(doc);

            Assert.AreEqual(doc["MY-STRING"].AsString, obj.MyString);
            Assert.AreEqual(doc["INTERNAL-PROPERTY"].AsString, obj.MyInternalPropertyNamed);
            Assert.AreEqual(doc["PRIVATE-PROPERTY"].AsString, obj.GetMyPrivatePropertyNamed());
            Assert.AreEqual(doc["PROTECTED-PROPERTY"].AsString, obj.GetMyProtectedPropertyNamed());
            Assert.AreEqual(obj.MyString, nobj.MyString);
            //Internal
            Assert.AreEqual(obj.MyInternalPropertyNamed, nobj.MyInternalPropertyNamed);
            Assert.AreEqual(obj.MyInternalPropertySerializable, nobj.MyInternalPropertySerializable);
            Assert.AreEqual(nobj.MyInternalPropertyNotSerializable, null);
            //Private
            Assert.AreEqual(obj.GetMyPrivatePropertyNamed(), nobj.GetMyPrivatePropertyNamed());
            Assert.AreEqual(obj.GetMyPrivatePropertySerializable(), nobj.GetMyPrivatePropertySerializable());
            Assert.AreEqual(nobj.GetMyPrivatePropertyNotSerializable(), null);
            //protected
            Assert.AreEqual(obj.GetMyProtectedPropertyNamed(), nobj.GetMyProtectedPropertyNamed());
            Assert.AreEqual(obj.GetMyProtectedPropertySerializable(), nobj.GetMyProtectedPropertySerializable());
            Assert.AreEqual(nobj.GetMyProtectedPropertyNotSerializable(), null);
        }
    }
}

redpajama_set_name: RedPajamaGithub


text:
'use strict';

import React from 'react';
import {_} from 'underscore';
import $ from 'jquery';

var dropdownStyle = {
    display: 'inline-block',
    marginRight: '10px'
};

var dropdownButtonStyle = {
    backgroundImage: 'none'
};

var clickableStyle = {
    cursor: 'pointer'
};

var drillDownControlStyle = {
    cursor: 'pointer',
    width: '20px'
};

function camelCaseToTitleCase(camelCase) {
    var result = camelCase.replace( /([A-Z])/g, " $1" );
    return result.charAt(0).toUpperCase() + result.slice(1);
}

function getDataFromUrl(url) {
    return new Promise((resolve, reject) => {
        $.ajax({
            url: url,
            dataType: 'json',
            success: (data => resolve(data)),
            error: ((xhr, status, error) =>  reject(xhr, status, error))
        });
    });
}

function pivotData(data, groupBys, summaries, sortColumn, sortAscending) {
    function groupToRow(group, key) {
        return _.extend(
            {rawData: group, key: key},
            _.extend(
                _.object(groupBys, groupBys.map(gb => group[0][gb])),
                _.object(summaries, summaries.map(s => _.reduce(_.pluck(group, s), (a, b) => a + b)))));
    }
    var groups = _.values(_.groupBy(data, d => _.map(groupBys, gb => d[gb] )));
    var key = 0;
    var sortedResults = _.sortBy(groups.map(g => groupToRow(g, key++)), r => r[sortColumn]);
    return sortAscending ? sortedResults : sortedResults.reverse();
}

var HeaderRow = React.createClass({
    propTypes: {
        groupBys: React.PropTypes.arrayOf(React.PropTypes.string).isRequired,
        summaries: React.PropTypes.arrayOf(React.PropTypes.string).isRequired,
        sortColumn: React.PropTypes.string.isRequired,
        sortAscending: React.PropTypes.bool.isRequired,
        onChange: React.PropTypes.func
    },
    updateSort: function(sortColumn) {
        var newSortAscending = this.props.sortColumn == sortColumn ? !this.props.sortAscending : true;
        this.props.onChange(sortColumn, newSortAscending);
    },
    render: function() {
        var sortClass = this.props.sortAscending ? 'glyphicon glyphicon-arrow-up' : 'glyphicon glyphicon-arrow-down';
        var groupByHeaders = this.props.groupBys.map(gb =>
             this.updateSort(gb)}>
                {camelCaseToTitleCase(gb)}
                {this.props.sortColumn == gb ?  : }
            	);
        var summaryHeaders = this.props.summaries.map(s =>
             this.updateSort(s)}>
                {camelCaseToTitleCase(s)}
                {this.props.sortColumn == s ?  : }
            	);
       return (

	{groupByHeaders}{summaryHeaders}

)
   }
});

var GroupRow = React.createClass({
    propTypes: {
        selectedGroupBys: React.PropTypes.arrayOf(React.PropTypes.string).isRequired,
        selectedSummaries: React.PropTypes.arrayOf(React.PropTypes.string).isRequired,
        groupBys: React.PropTypes.arrayOf(React.PropTypes.string).isRequired,
        summaries: React.PropTypes.arrayOf(React.PropTypes.string).isRequired,
        row: React.PropTypes.object.isRequired
    },
    getInitialState: function() {
        return {
            showDrillDown: false
        }
    },
    toggleDrillDown: function() {
        var showDrillDown = ! this.state.showDrillDown;
        this.setState({showDrillDown: showDrillDown});
    },
    render: function() {
        var cellKey = 0;
        var groupValues = this.props.selectedGroupBys.map(gb => {this.props.row[gb]}	);
        var summaryValues = this.props.selectedSummaries.map(s => {this.props.row[s]}	);
        var drillDownClassName = this.state.showDrillDown ? 'glyphicon glyphicon-minus' : 'glyphicon glyphicon-plus';
        var drillDownControl =
            this.props.row.rawData.length > 1
                ?
                : 	;
        var drillDownColSpan = this.props.groupBys.length + this.props.summaries.length + 1;
        var drillDownRow = (

                    <PivotTable groupBys={this.props.groupBys}
                                summaries={this.props.summaries}
                                data={this.props.row.rawData}
                                hideControls={true}/>

        );
        return (

{drillDownControl}{groupValues}{summaryValues}

                {this.state.showDrillDown ? drillDownRow : null}

);
    }
});

var DropdownSelection = React.createClass({
    propTypes: {
        title: React.PropTypes.string.isRequired,
        options: React.PropTypes.arrayOf(React.PropTypes.string).isRequired,
        onChange: React.PropTypes.func
    },
    getInitialState: function() {
        return {
            selectedOptions: this.props.options.slice()
        }
    },
    toggleOption: function(option) {
        var selectedOptions = this.state.selectedOptions.slice();
        if (selectedOptions.indexOf(option) > -1) {
            selectedOptions.splice(selectedOptions.indexOf(option), 1)
        } else {
            selectedOptions.push(option);
        }
        this.setState({selectedOptions: selectedOptions});
        this.props.onChange(selectedOptions);
    },
    render: function() {
        var optionElements = this.props.options.map(option => {
            var isSelected = this.state.selectedOptions.indexOf(option) > -1;
            return (

                 this.toggleOption(option)}>
                    {isSelected ? :    }
                      {camelCaseToTitleCase(option)}

)});

        return (

            <button className="btn btn-default dropdown-toggle" type="button" data-toggle="dropdown" style={dropdownButtonStyle}>
                {this.props.title}

            </button>

                {optionElements}

);
    }
});

var PivotTable = React.createClass({
    propTypes: {
        groupBys: React.PropTypes.arrayOf(React.PropTypes.string).isRequired,
        summaries: React.PropTypes.arrayOf(React.PropTypes.string).isRequired,
        dataUrl: React.PropTypes.string,
        data: React.PropTypes.arrayOf(React.PropTypes.object),
        hideControls: React.PropTypes.bool
    },
    getInitialState: function() {
        return {
            selectedGroupBys: this.props.groupBys.slice(),
            selectedSummaries: this.props.summaries.slice(),
            sortColumn: this.props.groupBys[0] ? this.props.groupBys[0] : this.props.summaries[0] ? this.props.summaries[0] : undefined,
            sortAscending: true,
            data: this.props.data || []
        };
    },
    componentWillReceiveProps: function(nextProps) {
        this.setState({
            sortColumn: nextProps.groupBys[0] ? nextProps.groupBys[0] : nextProps.summaries[0] ? nextProps.summaries[0] : undefined
        });
    },
    componentDidMount: function() {
        if (this.props.dataUrl) {
            getDataFromUrl(this.props.dataUrl)
                .then(data => this.setState({data: data}))
                .catch((xhr, status, error) => {
                    console.error('Failed to retrieve pivot table data from ' + this.props.dataUrl, status, error.toString())
                });
        }
    },
    groupBysUpdated: function(selectedGroupBys) {
        this.setState({selectedGroupBys: selectedGroupBys});
    },
    summariesUpdated: function(selectedSummaries) {
        this.setState({selectedSummaries: selectedSummaries});
    },
    headerRowUpdated: function(sortColumn, sortAscending) {
        this.setState({sortColumn: sortColumn, sortAscending: sortAscending});
    },
    render: function() {
        var pivotRows = pivotData(this.state.data, this.state.selectedGroupBys, this.state.selectedSummaries, this.state.sortColumn, this.state.sortAscending);
        var groupRows = pivotRows.map(pr =>
            <GroupRow selectedGroupBys={this.state.selectedGroupBys}
                      selectedSummaries={this.state.selectedSummaries}
                      groupBys={this.props.groupBys}
                      summaries={this.props.summaries}
                      row={pr}
                      key={pr.key}/>);
        var controls = (

                    <DropdownSelection title="Group By" options={this.props.groupBys} onChange={this.groupBysUpdated}/>
                    <DropdownSelection title="Summaries" options={this.props.summaries} onChange={this.summariesUpdated}/>

        );
        return (

                {this.props.hideControls ?  : controls}

                            <HeaderRow groupBys={this.state.selectedGroupBys}
                                       summaries={this.state.selectedSummaries}
                                       sortColumn={this.state.sortColumn}
                                       sortAscending={this.state.sortAscending}
                                       onChange={this.headerRowUpdated}/>
                            {groupRows}

        )
    }
});

export default PivotTable;