text:
Structure Based Identification of Potential Inhibitors of NS3 Protein of Zika Virus
Author(s): Md. Imam	Faizan, Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India	Abu Turab	Naqvi, Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India	Md. Imtaiyaz	Hassan, Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India	Mohd.	Abdullah, Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India	Ayesha	Tazeen, Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India	Zoya	Shafat, Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India	Malik	Hisamuddin, Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India	Aftab	Alam, Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India	Shahnawaz	Ali, Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India	Sher	Ali, Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India	Anam	Farooqui, Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India	Abu	Hamza, Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India	Nazish	Parveen, Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India	Farah	Deeba, Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India	Anwar	Ahmed, Protein Research Chair, Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia	Shama	Parveen*. Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India
Journal Name: Letters in Drug Design & Discovery
Background: The re-emerging Zika virus has posed a serious threat to human health due to its association with the neurological disorders. The NS3 protein of Zika virus plays a pivotal role in the genome replication and thus may prove to be a critical target for the drug designing studies.
Objective: The present study was conceptualized to analyze the crystal structure of NS3 protein of Zika virus followed by the identification of it's potential inhibitors.
Methods: Crystal structure of the NS3 protein was evaluated in detail. Docking of the NS3 protein was done with 130 different ligands including dengue virus inhibitors and their similar compounds along with some approved drugs. The drug likeliness properties were checked for non drug compounds.
Results: Structural analysis of the NS3 protein revealed three important sites namely ATP- and RNAbinding sites as well as a central cavity. The selected ten ligands (ZINC05487635, ZINC0092398, ZINC13345444, 4-methoxyphenyl 4-chloro-3-nitrobenzoate, Luteolin, Ivermectin, Suramin, Dasatinib, Panduratin A, and ARDP0009) showed a higher binding affinity for the NS3 protein and good drug likeliness properties.
Conclusion: These inhibitors could possibly act as potential lead molecules for future drug designing studies. Our present computational data is envisaged to be useful for gathering experimental evidences towards the development of potential therapeutic molecules against this arthropod mediated pathogen.
Keywords: Zika virus, NS3 protein, inhibitors, antiviral drugs, molecular docking, structure based drug design and discovery.
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Letters in Drug Design & Discovery
Title:Structure Based Identification of Potential Inhibitors of NS3 Protein of Zika Virus
Author(s):Md. Imam	Faizan, Abu Turab	Naqvi	, Md. Imtaiyaz	Hassan, Mohd.	Abdullah, Ayesha	Tazeen, Zoya	Shafat, Malik	Hisamuddin, Aftab	Alam, Shahnawaz	Ali, Sher	Ali, Anam	Farooqui, Abu	Hamza, Nazish	Parveen, Farah	Deeba, Anwar	Ahmed and Shama	Parveen*
Affiliation:Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, Protein Research Chair, Department of Biochemistry, College of Science, King Saud University, Riyadh, Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi
Keywords:Zika virus, NS3 protein, inhibitors, antiviral drugs, molecular docking, structure based drug design and discovery.
Md. Imam	Faizan, Abu Turab	Naqvi	, Md. Imtaiyaz	Hassan, Mohd.	Abdullah, Ayesha	Tazeen, Zoya	Shafat, Malik	Hisamuddin, Aftab	Alam, Shahnawaz	Ali, Sher	Ali, Anam	Farooqui, Abu	Hamza, Nazish	Parveen, Farah	Deeba, Anwar	Ahmed and Shama	Parveen*, "Structure Based Identification of Potential Inhibitors of NS3 Protein of Zika Virus ", Letters in Drug Design & Discovery (2019) 16: 761. https://doi.org/10.2174/1570180815666180821105012


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Although Laser Radar has been in use for almost a decade, the new software suite simplifies its programming and operation.
Screen shot of Metrolog X4 i-Robot as it controls and synchronizes the motions of both the robot and the Laser Radar.
After six years in development, Nikon Metrology and software developer Metrologic Group (metrologicgroup.com) have released a new production line-ready 3D metrology system in which Nikon's robot-mounted Laser Radar is programmed with Silma X4 i-Robot simulation software and controlled and automated by Metrolog X4 i-Robot software.
Nikon Laser Radar is an automated, non-contact measurement system for applications of up to 50-m radius that is fitted to a six-axis robot arm. It precisely measures geometry without requiring photogrammetry targets, laser tracker spherically mounted retro-reflectors or probes. Laser Radar is not sensitive to lighting or temperature and can measure most surfaces, including glass. It can also measure through transparent materials. Accuracies range from 24µm at a 2-m distance to 300µm at a 30-m distance. Inspection speeds reach 2,000 points per second in Vision Scan capture mode.
Although Laser Radar has been in use for almost a decade, the new software suite greatly simplifies its programming and operation. Metrolog X4 i-Robot controls and synchronizes the motions of the robot and the Laser Radar. It can accommodate any robot cell, including a 7th axis rail or a rotary table axis—or even multiple robots. The solution is independent of the robot accuracy; therefore, robot drift, warm-up and backlash do not influence the results. The system simply executes single or multiple part programs that can easily adapt to different part models or variations.
Silma X4 i-Robot is a virtual, offline programming and simulation tool that can generate automatically optimized Laser Radar and robot positions. It handles the robot constraints (singularities, over speed, limits) and Laser Radar specifics (line of sight, incidence angle, etc.) to combine optimized and collision-free trajectories. The software automates what was formerly a complex programming operation.


DESPITE talk of recession and worldwide financial crisis, Australia's Reserve Bank believes many of us have never been better off.
It backs its claim with statistics in its half-yearly Financial Stability Review, though it notes that retirees are an exception.
The real after-tax incomes of households on wages have jumped 10 per cent in the past year — more than double the usual rate.
The bank says the December stimulus payments were responsible for much of the rise, along with tax changes in the middle of last year.
For households with interest bills, things are even better. The bank says the ratio of interest payments to disposable incomes has fallen from 15 per cent to 11 per cent and is set to fall further, undoing five years of growth.
The bank also notes that petrol prices are down.
Household wealth has fallen about 10 per cent in the year, with the biggest blow being tumbling share prices, which are down around 50 per cent. By contrast, house prices are down just 4 per cent.
But the bank says most of the share price pain has been felt by wealthiest 20 per cent of households, most of which are still on good wages "and so are likely to have other sources of income to offset the decline in the value of their financial assets".
On the other hand, the downturn has been dire for retirees not receiving benefits. The bank says many will have lost half their sharemarket wealth, "most likely resulting in a large fall in their available income". About half of Australia's top 200 companies have cut their dividends, about a quarter of them by more than 50 per cent.
The bank is unconcerned by talk of people having trouble paying mortgages, reporting that across the millions of home loans in Australia only 20,000 are more than three months behind. While this is an increase of 7000 on the year before, it remains minuscule by foreign standards.
In only one region of Victoria are there more than 2000 home loans in arrears — the Latrobe Valley, and even there the arrears rate is below 1 per cent.
Separately, the bank's head of economic analysis, Anthony Richards, told a housing conference he was not concerned about a jump in arrears when mortgage rates eventually began to climb.
"Our discussions with banks indicate that they are indeed testing the ability of borrowers to continue servicing their loans if interest rates were to rise," he said. "No doubt, as at any time, some of the loans being written now will turn sour.
"However, overall, I suspect that the risk of non-performing loans increasing to the extent seen in the United States is low."
The Reserve says business borrowers have also benefited, with big businesses enjoying rates 3.7 points lower on average and small businesses paying rates 2.3 points lower.


text:
3D View: Structure | Electron Density
2ESK
Human Ubiquitin-Conjugating Enzyme (E2) UbcH5b, wild-type
DOI: 10.2210/pdb2ESK/pdb
Classification: LIGASE
Deposition Author(s): Ozkan, E., Yu, H., Deisenhofer, J.
Mechanistic insight into the allosteric activation of a ubiquitin-conjugating enzyme by RING-type ubiquitin ligases
Ozkan, E., Yu, H., Deisenhofer, J.
(2005) Proc.Natl.Acad.Sci.Usa 102: 18890-18895
2ESQ, 2ESP, 2ESO
Ubiquitin-conjugating enzymes (E2s) collaborate with the ubiquitin-activating enzyme (E1) and ubiquitin ligases (E3s) to attach ubiquitin to target proteins. RING-containing E3s simultaneously bind to E2s and substrates, bringing them into close prox ...
Ubiquitin-conjugating enzymes (E2s) collaborate with the ubiquitin-activating enzyme (E1) and ubiquitin ligases (E3s) to attach ubiquitin to target proteins. RING-containing E3s simultaneously bind to E2s and substrates, bringing them into close proximity and thus facilitating ubiquitination. We show herein that, although the E3-binding site on the human E2 UbcH5b is distant from its active site, two RING-type minimal E3 modules lacking substrate-binding functions greatly stimulate the rate of ubiquitin release from the UbcH5b-ubiquitin thioester. Using statistical coupling analysis and mutagenesis, we identify and characterize clusters of coevolving and functionally linked residues within UbcH5b that span its E3-binding and active sites. Several UbcH5b mutants are defective in their stimulation by E3s despite their abilities to bind to these E3s, to form ubiquitin thioesters, and to release ubiquitin at a basal rate. One such mutation, I37A, is distant from both the active site and the E3-binding site of UbcH5b. Our studies reveal structural determinants for communication between distal functional sites of E2s and suggest that RING-type E3s activate E2s allosterically.
Department of Biochemistry and Pharmacology and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA.
Ubiquitin-conjugating enzyme E2 D2
Gene Names: UBE2D2 (PUBC1, UBC4, UBC5B, UBCH4, UBCH5B)
EC: 2.3.2.23
Go to Gene View: UBE2D2

redpajama_set_name: RedPajamaCommonCrawl


KABUL: NATO's International Security Assistance Force (ISAF) has said attacks by anti-government armed groups against foreign forces declined by 17 percent in the first seven months of the current year, as compared to the same period in 2011.
Brigadier General Günter Katz, spokesman for the international force, told journalists here on Monday (Sept. 24) that attacks on their troops by armed rivals decreased by 9% percent in August 2012, as compared to the same month last year.
He said numerous attacks by the Taliban and other armed groups were repelled and the gunmen were ousted from key areas and cities of Afghanistan, adding capacity of the Afghan security forces has also been raised as a result decline in rival attacks were reported.
If we compare Taliban attacks conducted in the current year with attacks in 2010 then the attacks declined by 30 percent, he claimed.
He continued that if attacks in the first seven months of 2012 are compared with the same period in last year then these attacks decreased by 17 percent.
Brigadier General Günter Katz said Taliban were still using roadside bombs which, he said, cause casualties to civilians.
He, however, admitted that Taliban attacks and activities in some areas of the war ravaged Afghanistan increased this year.
He said ISAF findings suggested that near 80 percent Taliban attacks and operations were conducted in remote districts and far flung areas which has 20 percent population of Afghanistan.
ISAF reports decline in Taliban attacks at a time when some media reports suggested that Taliban were increased.
Taliban spokesman Zabihullah Mujahid rejected ISAF's claim as false and told Afghan Islamic Press (AIP), "We strongly and clearly rejected this claim.
Like the past, attacks by Taliban against the enemy continue while the enemy has retreated from numerous areas of the country and abandoned their major bases which resulted in decline in Taliban attacks."


text:
12th Congressional District update
by Michael Lowrey
From the UPoR:
Who has money: Alma Adams. She who is known for her hats has raised the most money and has the most money on hand. Adams is also the only woman in the race, which could also be a significant advantage.
Who doesn't have money: James "Smuggie" Mitchell, who's dropping out. Mitchell says that the arrest Patrick Cannon really cut into his fundraising ability, which is kind of ironic. The people he was counting on for $1,000 were suddenly only writing only $100 or $200 checks. "I think the whole city of Charlotte has been kind of in a shock mode," Mitchell said to the UPoR.
Who's trying to the spin the race. Or has the most interesting spin on the race: Sen. Malcolm Graham of Charlotte. "When you've got one candidate in Greensboro and four others in Charlotte the math becomes tricky for a Charlotte-based candidate. That's why it's important we rally around the one in Charlotte with the best chance of winning otherwise we lose the seat to Greensboro." Of course, Graham thinks that the candidate from Charlotte everyone should rally around is him. Note that he's effectively saying that Adams will get through to the runoff.
Demographic note: With the amount of population growth in North Carolina, we can expect the state to add a congressional seat come 2022. And with Mecklenburg County's population growing as much as it has, it may well also eliminate the need for a Charlotte to Greensboro bug-splat of a district to elect an African-American.
And the Meck Deck wishes you adieu
And speaking of American Airlines…
American Airlines' airport lease is up for renewal


text:
PublicSource | News for a better Pittsburgh (https://www.publicsource.org/public-transit-in-the-pittsburgh-area-is-at-risk-for-drastic-cuts-under-state-budget-proposal/)
Public transit in the Pittsburgh area is at risk for 'drastic' cuts under state budget proposal
By J. Dale Shoemaker | September 7, 2017
More on MONEY & POLITICS
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The Allegheny County Port Authority and its public transit system are at risk of losing $80 million in state funding under a state budget proposal. (Canadian Pacific/flickr)
A plan introduced Wednesday to balance the state budget threatens a significant amount of funding to the Allegheny County Port Authority and could result in its public transit system having to cut operations by up to half.
A proposed cut of $80 million to the agency could mean cuts twice as deep as what the agency sustained several years ago when it was left with a $35 million deficit.
Port Authority Spokesman Adam Brandolph said the 2011 and 2012 cuts in state funding and the resulting deficit caused the agency to eliminate 29 bus routes, close the Harmar garage and lay off 200 employees.
"These [cuts] would be similar if not much worse," he said. "We would anticipate these cuts to be just as drastic if not twice as drastic."
Proposed cuts to various pots of state money — including funds that are allocated to public transit — were the Republican lawmakers' way of proposing a balanced state budget more than two months after the deadline has passed. In total, their proposal finds $2.4 billion that would cover the state's deficits from both last year and this one. Rank and file lawmakers said at a press conference yesterday that they didn't anticipate any programs to be affected by their proposal, though the Port Authority is preparing for the worst.
"We would anticipate these cuts to be just as drastic if not twice as drastic."
The $80 million on the chopping block accounts for nearly a third of the funding the agency receives from the state. This fiscal year, the Port Authority is set to receive nearly $241.88 million in state funding, which accounts for nearly 60 percent of its overall operating budget.
On top of the $80 million in direct cuts lawmakers proposed, Brandolph said a number of matching grants from both the county and the federal government could also be affected. Losing matching grants — meaning losing county and federal money that is only available after state funding is spent — could deepen the potential deficit. Brandolph couldn't provide a figure for how much matching funds could be at risk.
The plan proposed by lawmakers outlines a number of "one-time transfers" of monies that fund 911 call centers, cleanups of hazardous waste sites, highway beautification and historical preservation projects. Included in the cuts are $120 million from the Multimodal Transportation Fund and $375 million from the Public Transportation Trust Fund. Philadelphia's transit system, SEPTA, also faces drastic, potential cuts. The Philadelphia Inquirer reported on Wednesday that that agency could face up to $263 million in cuts.
The Commonwealth Foundation, a right-leaning think tank, defended the lawmakers' plan and argued in a blog post on Wednesday that the proposed "cuts" are only coming from reserve funds.
"These reserve funds have not been needed to pay bills related to mass transit," Nathan Benefield, vice president and COO of the foundation, wrote in the post.
Brandolph said the Port Authority was preparing a heavy counterattack to the budget proposal and would be outlining the impact of the potential cuts in letters the agency plans to send to Allegheny County lawmakers by next week.
"It's going to have a massive impact on people's lives."
One of those lawmakers likely to receive a letter, State Sen. Wayne Fontana (D-Allegheny) said the cuts would be particularly devastating to the elderly, people with disabilities and others who can't afford to drive, though he said it was unlikely that the plan would pass.
"When they start cutting routes and changing hours, the outcry will be immense," he said. "This will hurt the elderly and the disabled - that's the shame of it."
Less power use and meat-eating, more trees and public transit: What you need to know about Pittsburgh's new climate plan.
A baby born in Pittsburgh in 2017 will live in a very different city by the time she heads off to middle school in 2030, if a new city climate action plan bears out. The new plan outlines how dramatically the city will have to change to meet its goal to reduce greenhouse gases.
To anyone who rides the bus in Pittsburgh: PA turnpike debt is threatening your commute
Transportation Buried in last week's report about the deepening debt of the Pennsylvania Turnpike Commission was an early warning for the thousands of people in the Pittsburgh area who rely on public transit for rides to work or the grocery store.
In the hours following Wednesday's news conference, which GOP House leaders did not attend, Fontana said he'd already begun to receive calls from constituents urging him to help keep Port Authority's funding in place. He also said the lawmakers' logic in pulling money from dedicated funds doesn't make sense.
"They think taking money from a fund because it's just sitting there isn't hurting anyone but it is, it's earmarked," he said. "And to stand up there and say it's not going to have any consequences? It blows my mind."
Public transit advocates, too, also began mobilizing shortly after the budget announcement. Laura Wiens, who works with the group Pittsburghers for Public Transit, said her group would push back against the proposal and fight to help keep the Port Authority funded. She noted that more than half of the people who travel Downtown use public transit and that those who are most vulnerable will be hit the hardest.
"It's not an exaggeration to say it's going to have a drastic affect on the Allegheny County economy," she said. "It's going to have a massive impact on people's lives."
(This story was updated at 7 p.m. Sept. 7, 2017, to include additional information.)
You can reach J. Dale Shoemaker at 412-515-0069 or dale@publicsource.org. He's on Twitter at @JDale_Shoemaker.
2 thoughts on "Public transit in the Pittsburgh area is at risk for 'drastic' cuts under state budget proposal"
Kevin Schmidt on September 15, 2017 at 3:39 am said:
LOL! I can't believe you censored my comment!
All I said was that PA should do what CA did. Vote out the Republicans and raise taxes on the wealthy to balance the budget and provide for the welfare of the people. What the hell is wrong with that?
Kevin Schmidt on September 14, 2017 at 7:48 pm said:
PA should do what California did. We voted out the Republicans, raised taxes on the wealthy, and now we have balanced budgets and our citizens are not suffering from austerity any more.


text:
American Missiles
The Complete Smithsonian Field Guide
Brian Nicklas
This remarkable guide provides for the
first time an illustrated listing of almost
200 of America's most powerful missiles.
With information on all aspects of the
missile's specifications, including the
speed and capacity of the explosives
used in its warhead, this book provides
a comprehensive guide to the US
Army's projectile hardware. American
over 200 color/b/w photographs
Dimensions : 9 X 6.5 inches
This remarkable guide provides for the first time an illustrated listing of almost 200 of America's most powerful missiles. With information on all aspects of the missile's specifications, including the speed and capacity of the explosives used in its warhead, this book provides a comprehensive guide to the US Army's projectile hardware. 'American Missiles: The Complete Smithsonian Field Guide' draws heavily on the Herbert S. Desind Photo Collection, a resource of more than 110,000 images recently catalogued at the National Air and Space Museum. Of interest to both the specialist and the aviation enthusiasts, this book demonstrates the evolution of American missile design over the last forty years in an accessible and entertaining format.
Brian Nicklas is a life-long enthusiast of aviation and studied Aeronautical Studies at Embry-Riddle Aeronautical University, Daytona Beach, Florida. As a writer and photographer, he has been published in several newspapers, magazines and calendars, and has written for aviation websites. Since 1987, he has been a member of the Archives Division of the Smithsonian Institution's National Air and Space Museum. He lives near Washington DC.
"A sound source of factual information."
- Spaceflight
"This book will probably become the definitive work on the subject for the period covered and provides fast access to facts on the range of US missiles produced since 1962."
- FIRE Reviews
"I found the title to be very informative. The book is a great primer on US Missiles and well worth it just for the detailed introduction and the information on naming and designations. I have enjoyed reading this title and recommend it as a general reference on US Missiles."
- Hyperscale
"The Complete Smithsonian Field Guide American Missiles by Brian D. Nicklas is the first book that covers all American missiles in the modern U.S. military designation system from the MGM-1 (Matador) to the present RIM-174 ERAM. All previous U.S. missile directories have only been snapshots of what missiles were active at the time. This meticulously-written, beautifully illustrated and invaluable work has been a labor of love for Nicklas, a Museum Specialist with the National Air and Space Museum of the Smithsonian Institution for 22 years with the Archives Division. In addition, the book contains a very useful Bibliography, including historical works, including several that cover the historical foundations of missiles, plus a list of missiles with modern designations within the Museum's collections."
- Frank H. Winter, Retired Curator of Rocketry, National Air and Space Museum.
American Missiles Reviews
The Forgotten VCs
Brian Best
The Lines of Torres Vedras
John Grehan
The Battle of Neuve Chapelle
The Sniper Anthology
Julius Caesar's Invasion of Britain
Roger Nolan
The Battle of Bellicourt Tunnel
Dale Blair
The Duke of York's Flanders Campaign
Letters from Kimberley


text:
Portraits / People
Landscape / Fine Art
Food / Beverage
Home / Images / The Underpants
The Underpants
by Damian Vines on March 11, 2015 with No Comments
Catchy title huh? This is the name of a 1910 stage play that was originally written by playwright Carl Sternheim. The original German farce was called Die Hose and later adapted by Steve Martin and renamed, The Underpants. I had the pleasure of taking the promotional photos for the Mount Baker Theatre's production of this play recently. Mount Baker Theatre's repertory theater has produced some amazing plays in its 3 year of its existence; My Fair Lady, Into the Woods, The Producers, Little Shop of Horrors, to name a few. It's been a real treat to work with the theatre over the years. The opportunity to assist and create the photographic images that will help to promote the show is truly as rewarding as it is challenging. Often as is the case with advertising and promotion, early deadlines and advance printing can be a challenge for a production that often times doesn't come together until the last few weeks or days before opening. We'll often have to shoot promotional images 2 months in advance of show opening. This forces us to be quite creative in staging, costuming, location scouting and creative brainstorming to come up with the idea that will become the playbill image or cover image for local magazines. The image here of the actors/characters in their period costumes was no exception. We had to beg borrow and steal from anyone that had early 1900's clothing, as mentioned early, we wouldn't have the actually costumes for months. The location scouting was challenging because we wanted to find some location that wouldn't give away our modern time period and that had the charm and look of the early 1900's. Alas, and of course for you locals, Fairhaven near Bellingham, WA turned out to be just the ticket. The town is steeped and brimming with an old timey vibe and décor to match. The image above was shot in Finnegan's Alley up on the balcony. This vantage point provided us with the perfect look and feel. Our plan was to capture our actors as if they were up above the crowd looking down on a parade going by, one of the scenes in the play. I love collaborating with a team of people to make a shoot come together. I certainly don't work alone on these types of shoots with the Mount Baker Theatre, I have to give them a huge thank you for doing all of the costuming and coordinating with the actors schedules getting them to the shoot. I encourage you to check out the Mount Baker Theatre's repertory schedule. They always have a fantastic host of amazing in-house and traveling shows. Click here to find out more: Mount Baker Theatre
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Aurora Borealis Hits Home July 1, 2015
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There are several methods to pivot, or transpose, data in T-SQL, but most are difficult to understand and write. Phil Factor demonstrates how to take advantage of JSON support, introduced with SQL Server 2016, to create a function that makes pivoting data simple.
Many developers just want to 'rotate', pivot or transpose a result as if it were a matrix. This involves turning columns into rows by, in effect, transposing the two coordinates. There is, of course, a lot of difference between a pivot and a transpose because columns in a SQL Table represent the discrete values of entities, not values in a range. However, we are all faced with data in a table format such as an Excel PivotTable or a tabular report that may be a table but not a relational table. Often, we want to pivot it/do a transpose. Usually, neither a pivot or a tabular report are, strictly, relational tables, but if we are in the midst of delivering meaningful reports, who cares? A lot of systems need reports in a particular format and we have to provide that.
There is a problem here because someone is going to add some columns to represent recent data. What about the two subsequent years at least 2016 and 2017? I've recently described some of the classic ways of doing this, and a good brute-force JSON technique to achieve the same, but they have the problem that the code to do the rotation needs to change when those extra rows are added. What about a technique that goes further by transposing/pivoting data of any size? Well, sure, as long as it is a JSON table, but there is just a little essential task at the end to provide the column names and datatypes of the SQL Server result.
Let's just demonstrate what I mean as simply as possible. We start with a simple result produced by this test code.
That line at the end is important because it tells the system function OpenJSON() what columns you want from the JSON document and what SQL Datatype they should be. This task is essential because there is a loss of metadata when a table is converted into JSON. We don't know much about numbers when they are stored in JSON, only that something is a number.
Despite the change in the number of rows and columns, we can use the same routine, unaltered. We just need, when we use the function, to define the extra two columns that result from there being two extra rows in the original.
You will have noticed a problem. What about the column headings (One to Five). Those have gone. Shouldn't we have made them into row headings?
In this particular example of the matrix we don't have to, but we can. We can reference what were the column headings as another column ''$.Col0'', to transpose what were the row headings into column headings.
Here is the code of the procedure used in the preceding examples. All we are really doing is to take a matrix of one consistent data type and to transpose it. We can't add a column of strings, because that would equate to a row of strings in a table of integers which makes no sense in SQL Server. JSON can cope with it without any problem at all, but only because it is not, by default, a way of representing tabular data. All we are really doing is to use the OpenJSON() function to unwrap the JSON into a relational table that records each cell and its value, together with its column and row. We then create a new JSON document with transposed rows and columns. Because we pass JSON in and out of the function we avoid the problems that we'd have with doing the same thing with tables.
+ Stuff --we will be concatenating a list of rows.
Now we can put our generic function through its paces to test it out. Here is the data before the transpose.
-- we can avoid iteration for small tables!
Now the first example we gave at the start of the article is generated simply by following the same pattern. Remember that this code would be very small were it not for the fact that we are generating the data table as a table-source, using several sets of row value expressions to be constructed into a table via the VALUE table-value constructor. This is useful when running a function through a series of unit tests because it keeps everything in one place.
What about doing other datatypes besides integers?
So far, we've stuck resolutely to integers in our matrix. As long as we are consistent, we can use whatever we like. Obviously, if we are pivoting a matrix, the cells will all need to have the same datatype in SQL Server.
We can to other datatypes. How about numeric?
What About the row and column aggregations?
Yes, that first example, the oil consumption totals, needed row and column totals, didn't it? We wanted to see how the petrol consumption increased over the years.
With a bit of a tweak that I'll show you in a moment, we can do this (I've highlighted the aggregation column and row).
…which, this being my lucky day, checks out if we do the totals using the SUM() function within Excel.
How could we do this so easily? You see, we had to shred the JSON into its normalised form anyway in order to do the transpose, so doing the aggregation within the function was the natural thing to do. Unfortunately, we can't do every type of aggregation within the one function, and we can't aggregate every datatype. You will have to build very slightly different functions for each.
There isn't that much code needed to perform this magic.
Inside the function, after we insert our data into the @TheNormalisedVersionOfTheMatrix table, we have a couple of extra insertions to do to get the extra column and row in.
Here is the code that produced the Oil Consumption figures with the added sum column and total row .
We can see the aggregation column just by specifying Colx as the column in the JSON path where x is one more than the number of data columns. (We used Col0 in the JSON path for the rotated column headings). The Total row just appears!
The code for both functions can be downloaded from the link at the bottom of the page.
I couldn't do any of this sort of trickery until the JSON support came into SQL Server 2016. I suspect that there is a way to use OpenXML to work the same magic, but I leave that for the keen reader, if any are still with me at this point. JSON is just so handy, and seems fast. It is a very relaxed way of getting data in and out of functions. It is also easy to debug. It was relatively easy to bring it to bear on a problem that has previously proved resistant to easy solution, the generic function to pivot data regardless of the number of rows and columns.
How would you cope with dynamic columns where the number of headers could change?
I assume you mean columns in the output table. (input columns are all put in the 'Col0' so no worries there). I didn't go into this because isn't part of the function. The function itself merely returns a JSON document and there are ways of converting that into a SQL result using OpenJSON when you don't know how many columns there are. This is easier because the columns all have the same datatype and merely increment the column number. You can be certain that the JSON will represent a tabular format in a particular way. Have you looked at https://www.red-gate.com/simple-talk/blogs/consuming-hierarchical-json-documents-sql-server-using-openjson/ ? That should give you a start.
My solution to doing this is a bit clunky because it uses dynamic SQL but you might get a better idea!
My only concern would be how you would deal with a SQL Result where you don't know the number of columns!
There's just too much hard-coded data in your examples to make it even conceivable in real-world scenarios. Why don't you use a real table as the source, I'm sure this would make more sense to many of the readers?
Sorry. I hadn't realised it was a problem. It was done purely to cut down on the amount of code in the article. It deals fine with ordinary tables. I'll see if we can add a more conventional table to the article.
Nice. I imagine a cast to sqlvariant would unshackle the function's data type constraint. Never thought I would say that… And I assume a constraint on resource consumption is needed, otherwise I fear this hammer of a function will nail SQL Server ;).


text:
Lee Circle is a central traffic circle in New Orleans, Louisiana, which featured a monument to Confederate General Robert E. Lee between 1884 and 2017. The monument was a bronze statue by Alexander Doyle, a prominent American sculptor known for statues of Civil War figures.  Lee Circle is located at the intersection of St. Charles and Howard Avenues. Prior to the erection of the monument, the location was known as Tivoli Circle or Place du Tivoli.  Tivoli Circle was an important, central point in the city, as it linked upriver areas with downriver areas.  It was a common local meeting point and the site remains a popular place to gather for Mardi Gras parades.

Renaming controversies
On July 31, 1877, "Lee Place" within "Tivoli Circle" was authorized by Ordinance A.S. 4064  Although the traffic circle is commonly referred to as "Lee Circle", this ordinance makes clear that the "enclosure" containing the statue is to be known as "Lee Place", while the traffic circle itself continues to be known as "Tivoli Circle". This ordinance contains no reference to the name "Lee Circle".

On June 24, 2015, New Orleans Mayor Mitch Landrieu acknowledged the impact of the June 2015 Charleston church shooting but credited a 2014 conversation with New Orleans jazz ambassador Wynton Marsalis for his decision to call for the removal of the Lee statue and renaming of Lee Circle and other city memorials of Confederate slaveholders.

As part of a sixty-day period for public input, two city commissions called for the removal of four monuments associated with the Confederacy: the Lee statue, statues of Jefferson Davis and P.G.T. Beauregard, and an obelisk commemorating the "Battle of Liberty Place".  Governor Bobby Jindal opposed the removals.

On December 17, 2015, the New Orleans City Council voted to remove the four monuments from public display. Four organizations immediately filed a lawsuit in federal court the day of the decision and the City administration agreed that no removals would take place before a court hearing.

Removal of the Lee statue
On May 18, 2017, the City of New Orleans announced that the Lee statue would be removed at 9 a.m. the following day. This was the last of the four Confederate memorials to be removed by the city. The city also announced that the statue would be replaced with a water feature.

The removal of the Lee statue was completed on the evening of May 19 at 6 p.m. C.D.T., a departure from the other removals which occurred during early morning hours under the cover of darkness.

On February 23, 2019, a rider was banned for life from a Mardi Gras parade for throwing beads bearing the likeness of the Lee statue, which she had created and sold online as a business venture for profit.  The beads were against a city ordinance that restricts advertising and political messaging, and were known to be non-compliant within Orleans Parish.

See also
 Robert E. Lee Monument (New Orleans, Louisiana)
 List of streets of New Orleans

References

Further reading

  Published on the occasion of the dedication of the John Hancock Building (now known as K&B Plaza), New Orleans, LA, December 7, 1961.

Geography of New Orleans
Transportation in New Orleans
Streets in New Orleans
Monuments and memorials to Robert E. Lee

redpajama_set_name: RedPajamaWikipedia


text:
Risks & Rewards of ExactTarget Deal Still Hinge on People, Ideas & Dollars
By Todd SaxtonSeptember 10, 2013
Todd Saxton is an associate professor of management at the IU Kelley School of Business Indianapolis, where he also serves as the Indiana Venture Faculty Fellow.
Earlier this quarter, Salesforce.com formally closed on its long-discussed acquisition of ExactTarget. As ownership of one of our region's largest high-tech employers shifts from Indianapolis to San Francisco, many questions remain: How will the acquisition impact local employees, the company's commitment to civic endeavors, its position as the anchor of a growing cluster of local digital marketing firms?
These questions may not be answered for some time. The entrepreneurial world isn't a place for the faint-hearted. This summer, we've seen a leadership change at one of the region's most visible entrepreneurial initiatives (Verge) and a major investigative report from the Star on the state's major source of public funds for start-ups (IEDC and Elevate Ventures). The entrepreneur always has to be ready for the next curveball.
But there are a few constants in successful entrepreneurship – namely, the core elements of people, ideas and money. The long-term impact of the ExactTarget acquisition will largely depend on the allocation and evolution of these critical resources:
First, human capital. As it was launched here and skyrocketed into a global corporation, ExactTarget has developed legions of executives who have gained valuable experience along the way. In the wake of the acquisition, how many of these employees will take the opportunity to start their own ventures…and will they stay in Central Indiana to do so?
ExactTarget can already claim 'parentage' of a number of enterprises launched by former employees. For example, co-founder Chris Baggott starting Compendium, the successful blogging platform headquartered on Monument Circle. If this process accelerates, the infusion of risk-taking talent into our entrepreneurial ecosystem will be a big win.
Then there is the intellectual property, new ideas. Large companies have the wherewithal to attract lots of smart people, who generate lots of good ideas. But conversely, big business is also hamstrung by its size – often too slow to take advantage of niche opportunities, too focused on quarterly earnings or core business priorities to see the potential in 'orphan technologies.'
ExactTarget is a big company that's getting a lot bigger. And to the extent its operations are assimilated into the even more mammoth structure of Salesforce.com, it may simply be unable to pursue every promising idea with the vigor of a smaller start-up. If opportunities are left on the table, the ability of would-be entrepreneurs now in the company's ranks (or outside the organization looking in) to liberate and commercialize this portfolio of intellectual property could be a tremendous economic opportunity.
Finally, the money – specifically, the estimated $2.5 billion price tag paid by Salesforce.com. While some of that money will flow into the pockets of venture capitalists on the coasts and investors outside Central Indiana, much of it will stay with ExactTarget's early investors, founders, and leading executives. If redeployed as angel investment and seed funding for the next generation of high-tech start-ups, these funds will leave a lasting legacy for Indiana's entrepreneurial community.
We should recall that this churn of people, innovative ideas and dollars plays out constantly in places like Silicon Valley, and can here in Indiana as well. After all, it was the IPO of Software Artistry in the late 1990s that led to the formation of Interactive Intelligence, Aprimo, and yes, ExactTarget. We should applaud the ExactTarget visionaries who have been rewarded for their ideas, risk, and hard work – and understand that uncertainty comes with opportunity.
Todd Saxton See More of 's Stories


With its many historic buildings, ancient streets, and unique character, Edinburgh is the perfect destination for immersing yourself in Scotland's fascinating history, culture and heritage.
Whether you spend your days exploring ancient ruins, palaces, and castles, sampling your favourite whisky in Edinburgh's many charming pubs, or indulging in leisurely walk along some of our ancient waterways, you're sure to leave with fond memories of Scotland's capital city.
And our holiday apartments are perfectly placed in the heart of Edinburgh's historic Old Town, meaning you're always only a short walk away from some of the city's most iconic landmarks and attractions.
Our Parliament Apartments are located at the front of a very prestigious building on Parliament Square, opposite the Edinburgh City Chambers (local Government Offices) on the famous Royal Mile and the rear of the magnificent St Giles Cathedral. Both apartments command a prestigious position in the very heart of Edinburgh's historic Old Town and only 300m to Edinburgh Castle. We also welcome in 2018 our new neighbours the French consulate to Parliament Square a very welcome addition to the neighbourhood.
Close to a wide range of restaurants, bars, eateries, shops, and cafes, just a stone's throw away from Edinurgh's main shopping streets, both apartments have been furnished to the highest possible standard - ensuring that you are able to rest, work and play in the optimum comfort. Both properties feature all of the home comforts and modern amenities that you would expect to find in a luxury apartment.
With so much happening throughout the year in Edinburgh, including the Edinburgh Festival, Christmas and Hogmanay, as well as events such as The Edinburgh Military Tattoo and Edinburgh's Winter Festival, it's always best to book up in advance due to limited availability during busy periods.


text:
import sys
import subprocess

def git_grep(params: [], error_msg: ""):
    try:
        output = subprocess.check_output(["git", "grep", *params], universal_newlines=True, encoding="utf8")
        print(error_msg)
        print(output)
        return 1
    except subprocess.CalledProcessError as ex1:
        if ex1.returncode > 1:
            raise ex1
    return 0

def main():
    # PRE31-C (SEI CERT C Coding Standard):
    # "Assertions should not contain assignments, increment, or decrement operators."
    exit_code = git_grep([
        "-E",
        r"[^_]assert\(.*(\+\+|\-\-|[^=!<>]=[^=!<>]).*\);",
        "--",
        "*.cpp",
        "*.h",
    ], "Assertions should not have side effects:")

    # Aborting the whole process is undesirable for RPC code. So nonfatal
    # checks should be used over assert. See: src/util/check.h
    # src/rpc/server.cpp is excluded from this check since it's mostly meta-code.
    exit_code |= git_grep([
        "-nE",
        r"\<(A|a)ss(ume|ert) *\(.*\);",
        "--",
        "src/rpc/",
        "src/wallet/rpc*",
        ":(exclude)src/rpc/server.cpp",
    ], "CHECK_NONFATAL(condition) or NONFATAL_UNREACHABLE should be used instead of assert for RPC code.")

    sys.exit(exit_code)

if __name__ == "__main__":
    main()

redpajama_set_name: RedPajamaGithub


text:
from django.db import models
from django import forms

# Create your models here.

class Join(models.Model):

	email = models.EmailField()
	timestamp = models.DateTimeField(auto_now_add = True, auto_now = False)
	updated = models.DateTimeField(auto_now_add = False, auto_now = True)

	password =  models.CharField(max_length=32)
	#password = models.CharField(max_length = 30)
	#e-mail information

	#password information
	#pTimestamp = models.DateTimeField(auto_now_add = True, auto_now = False)
	#pUpdated = models.DateTimeField(auto_now_add = False, auto_now = True)

	def __unicode__(self):
		return self.email


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May 18, 2021 | Victoria Hudgeons
Becoming certified in public health can deliver many career benefits. Certified professionals stand out among other job applicants, maintain current knowledge of best practices, and demonstrate expertise in their field.
Unlike certificates, which indicate completion of an educational course or program, professional certifications provide credentialing based on nationally recognized standards.
Individuals can pursue public health certifications at different career stages, including recent graduates and career professionals.
Career and Salary Outlook in Public Health
The public health field comprises scientific research, healthcare services, government policy, and education. Professionals work one-on-one with community members, develop and evaluate health programs, or research causes of disease outbreaks.
Three popular public health careers and relevant credentials are listed below. We have compiled the following information and data from the U.S. Bureau of Labor Statistics (BLS).
Epidemiologists
Epidemiologists work to reduce negative health outcomes by investigating causes of diseases, promoting community education, and advising on health policy. Epidemiologists typically work in offices and laboratories at state and local health departments, hospitals, or universities. Most epidemiologists hold master's degrees in public health.
Median Annual Salary (2020): $74,560
Projected Growth Rate (2019-2029): +5%
Health Educators and Community Health Workers
Health educators and community health workers implement strategies to improve public health and teach people about wellness. These professionals provide an important link between healthcare professionals and communities. Some employers require health educators to obtain certified health education specialist (CHES) or master certified health education specialist (MCHES) credentials.
Projected Growth Rate (2019-2029): +13%
Medical and Health Services Managers
Medical and health services managers plan, direct, and coordinate services in clinical departments and healthcare facilities. Some employers hire candidates with bachelor's degrees, while others require master's degrees. Managers can pursue certification through the Professional Association of Health Care Office Management, the American Health Information Management Association, or the American College of Health Care Administrators.
Median Annual Salary (2020): $104,280
Certified in Public Health
Offered by the National Board of Public Health Examiners, the voluntary CPH credential demonstrates competency in public health sciences and practices. As the only credential of its kind, more than 6,500 professionals have passed the CPH exam after it became available in 2008.
Earning a certification in public health demonstrates a professional's dedication to meeting and maintaining national standards, adhering to professional values, and following a core body of knowledge. To sit for the exam, a candidate must meet one of the following criteria:
Currently enrolled in a graduate school accredited by the Council on Education for Public Health (CEPH)
Alumni of a CEPH-accredited master's or doctoral program
Bachelor's degree and at least five years of public health work experience
Master's degree and at least three years of public health work experience
The standard exam fee is $385. Discounts are available for individuals enrolled in specific schools or programs and members of certain organizations.
Certified Health Education Specialist
The National Commission for Health Education Credentialing (NCHEC) designed the CHES exam for health education professionals in the early stages of their careers. This competency-based exam measures how well candidates understand, apply, and interpret entry-level competencies in the following seven key areas:
Assessing needs, resources, and capacity for health education
Planning health education
Implementing health education
Conducting evaluation and research related to health education
Administering and managing health education
Serving as a health education resource person
Communicating, promoting, and advocating for health and the health education/promotion profession
To sit for the exam, an applicant must hold a bachelor's degree with at least 25 credits specific to the seven key areas. Exam fees range from $220-$370 depending on student status and registration deadline.
Master Certified Health Education Specialist
Offered by the NCHEC, the MCHES credential suits experienced health education practitioners with advanced knowledge in the field. The MCHES exam covers both entry-level and advanced competencies in the seven NCHEC key areas listed above.
The MCHES exam emphasizes public health leadership skills, such as identifying staff development training needs, developing and managing budgets, and creating strategic plans.
To qualify for the exam, a CHES-certified professional should possess at least five years of active certification. Professionals without CHES certification can qualify if they hold a master's degree in a relevant discipline in addition to five years of experience as a health education specialist.
Exam fees range from $285-$435, depending on registration deadline.
Public Health Administrator
The Public Health Practitioner Certification Board, Inc., designed the voluntary public health PHA credential for public health professionals in administrative roles. It focuses on the following five competency areas:
Public health policy, advocacy, and law
Program development and evaluation
Public health administration
Obtaining the PHA requires at least a bachelor's degree and three years of administrative and supervisory experience in the public or private health sector. Each applicant must also provide evidence of fulfilling the five professional competencies through previous education or work experience.
Candidates do not need to pass an examination, but a $175 application fee applies. Professionals must renew their PHA credentials every three years by completing continuing education or academic credits.
Certified Physical Activity in Public Health Specialist
The American College of Sports Medicine, in collaboration with the National Physical Activity Society, designed the PAPHS certification exam. This credential is intended for professionals who promote physical activity in all areas of public health. It aligns with career goals in physical activity advocacy, policy, and program development/evaluation.
The PAPHS exam covers the following areas:
Planning and evaluating
Data and scientific information
Exercise science in public health settings
To sit for the exam, each applicant must hold a bachelor's degree in a health-related field. A candidate with a bachelor's in other subjects must possess at least 1,200 hours of experience in a setting that promotes physical activity or healthy lifestyle management to qualify. Exam fees range from $150-$195, depending on membership and certification status.
What is the difference between a certificate and a certification?
A certificate is a document proving completion of academic or vocational education. It is conferred by an educational program. Certifications, delivered by independent organizations, provide professional credentials earned through experience and/or examination.
Do I need to renew my certifications in public health?
Typically, yes. Most professional certifications require each candidate to complete a recertification process every few years. Specific requirements vary by credential, but this process often requires continuing education, proof of active employment, and recertification fees.
What certifications do I need to become a public health nurse?
Public health nurses, also called community health nurses, are registered nurses (RNs) who promote public wellness. RNs must obtain licensure by passing the NCLEX-RN examination. RNs can also pursue other public health certifications.
Bachelor's Degree in Public Health Master's Degree in Public Health Graduate Certificate in Public Health
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Providing administration support to the Project Manager and site team.
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List of BuildMoNa Scientific and Methods Modules in 2018 (inverse chronological order). Click on the Module Code to get more information on a Module.
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Home News NIH Issues Proposal on Using Animal Embryos Containing Human Cells
NIH Issues Proposal on Using Animal Embryos Containing Human Cells
A growing number of scientists have expressed interest in growing human tissues and organs in animals by introducing pluripotent human cells into early animal embryos. Formation of these types of human–animal chimeras holds tremendous potential for disease modeling, drug testing, and perhaps eventual organ transplant, say researchers. But uncertainty about the effects of human cells on off-target organs and tissues in the chimeric animals, particularly in the nervous system, raises ethical and animal welfare concerns.
In 2009 the NIH issued guidelines for human stem-cell research that specifically prohibit introducing human pluripotent cells into nonhuman primate blastocysts and the breeding of animals into which human pluripotent cells may have contributed to the germ line. Given the direction of the science, however, NIH felt that it was an appropriate time to consider whether further policy provisions regarding other chimera models were needed before making funding decisions.
Proposed Expansion of NIH Guidelines for Human Stem Cell Research [NIH]
Last fall the NIH put in place a funding moratorium for research proposing to introduce human pluripotent cells into animal embryos prior to the gastrulation stage.
Since the moratorium was issued, NIH has reviewed the state of the science and also held a workshop last November 2015 to bring together leading experts in the field of chimera research and animal welfare. Now the NIH has published in the Federal Register and the NIH Guide to Grants and Contracts a proposal to make two changes to its policy in this area, for which the agency is seeking public comment.
The NIH is establishing an internal NIH steering committee to provide programmatic input to NIH Institute and Center Directors in making funding decisions for two areas of research in which:
human pluripotent cells are introduced into nonhuman vertebrate embryos, up through the end of the gastrulation stage, with the exception of nonhuman primates, which would only be considered after the blastocyst stage, or
human cells are introduced into postgastrulation nonhuman mammals (excluding rodents), where there could be either a substantial contribution or a substantial functional modification to the animal brain by the human cells.
Proposed Scope of Chimera Research Considered by new NIH Steering Committee [NIH]
NIH wants public comment on the proposed scope of the chimera research to be considered by the NIH steering committee. The committee will focus on the experimental design and likely nature of the chimeric animal model. The committee's work will be independent of the peer review process. This committee will also monitor new developments in this field and provide analysis and advice to NIH leadership as needed.
NIH is also seeking comment on modifications to the NIH Guidelines for Human Stem Cell Research where the agency proposes to expand slightly the current prohibition on the introduction of human pluripotent cells into nonhuman primate embryos to include the preblastocyst stage, and to clarify that NIH will not fund research involving the breeding of animals where the introduction of any type of human cell may result in human egg or sperm development.
NIH officials say these actions are consistent with recently updated guidelines from the International Society for Stem Cell Research (ISSCR), which suggest that a specialized review of certain types of chimera research is appropriate. The ISSCR guidelines also contain useful suggestions of best practices for experimental design, which the research community is encouraged to consider, according to an NIH spokesperson.
Public comments regarding the NIH proposal can be made at http://grants.nih.gov/grants/rfi/rfi.cfm?ID=57.
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Cricket TimesThoughts, updates and news from Jimmy Cricket
Free Newsletter & Lyndene 2020
No More Fiffen & Faffen
Jimmy's Cricket Team
Page Three
Papal Knighthood KSG.
Find out more about Jimmy's life!
By:mhamer
'Meeting the legend that is Jimmy Cricket' – Karen's childhood dream comes true https://www.jimmycricket.co.uk/wp-content/themes/blade/images/empty/thumbnail.jpg 150 150 mhamer mhamer https://secure.gravatar.com/avatar/e3e9e71d9bef1ab16642587b224d590b?s=96&d=mm&r=g March 24, 2019 March 24, 2019
'Meeting the legend that is Jimmy Cricket' – Karen's childhood dream comes true
A fan of Jimmy Cricket saw a life-time ambition fulfilled when she met the famous comedian in person.
The Northern Irish entertainer was performing at the Comedy Lounge in Hull, East Yorkshire, on Friday (15 March).
Afterwards, @karenlouise80, who is a Fan's Liaison Officer at rugby league Super League club Hull KR, posted on Twitter: "@jimmy__cricket well a childhood dream of mine came true tonight,meeting the legend that is jimmy cricket "
Jimmy retweeted Karen's comment and posted: "What an electric atmosphere tonight, pictured here with the owners Paul and Bev @LoungeComedy in Hull my thanks also goes to comic/compère @dominicwoodward "
East Riding Film Festival: Jimmy Cricket to talk about The Quiet Man https://www.jimmycricket.co.uk/wp-content/themes/blade/images/empty/thumbnail.jpg 150 150 mhamer mhamer https://secure.gravatar.com/avatar/e3e9e71d9bef1ab16642587b224d590b?s=96&d=mm&r=g September 17, 2017 September 17, 2017
East Riding Film Festival: Jimmy Cricket to talk about The Quiet Man
Jimmy Cricket will be talking about his favourite film to a live audience at a festival on the East Yorkshire coast later this year.
The famous entertainer will be taking part in the East Riding Film Festival, which arranges for celebrities, film-makers and those with a deep knowledge of their subject to introduce films of their choosing.
Jimmy, 71, will be talking about The Quiet Man at the Bridlington Spa theatre on Sunday 12 November.
It will be followed by a question-and-answer session.
John Ford's 1952 classic film starred legendary actors John Wayne and Maureen O'Hara, who was an Irish-born American actress and singer. A comedy drama, it won an Oscar for the best cinematography that year. All the support actors were from the famous Abbey Theatre in Dublin.
You can buy a ticket to hear Jimmy talking about the film in November here.
Oh I do like to sing along the prom, prom, prom https://www.jimmycricket.co.uk/wp-content/themes/blade/images/empty/thumbnail.jpg 150 150 mhamer mhamer https://secure.gravatar.com/avatar/e3e9e71d9bef1ab16642587b224d590b?s=96&d=mm&r=g September 11, 2014 September 14, 2014
Oh I do like to sing along the prom, prom, prom
Jimmy Cricket did an unscheduled performance on the promenade in Bridlington this summer.
Over the August Bank Holiday weekend, the famous entertainer brought his stand-up comedy show to the Spa Bridlington theatre at the East Yorkshire resort.
As Jimmy was about to release his new comedy, I was bit by Luis Suarez, he decided to do some promotion of the song during the afternoon before his show began later that day.
So the Spa management arranged for him to have a pitch on the promenade outside their complex where Jimmy could belt out his new novelty song for those in the vicinity.
Many passers-by were intrigued by what was going on. John – pictured above with Jimmy – was one of those people and his friend, Richard, posted the photo above on Twitter, saying John could not stop mentioning it at work the next day!
The outdoor performance went well for Jimmy and later that day he also had a good crowd turning up to see his comedy show at the theatre – some who maybe came after their Sunday afternoon peaceful stroll along Bridlington Prom had been interrupted by a well-known Northern Irishman!
I was bit by Luis Suarez is based on the Uruguay and former Liverpool striker who was banned for four months for biting Italy defender Giorgio Chiellini during the World Cup in Brazil this summer.
To watch the video of the song, visit Jimmy's video channel at YouTube here.
And you can pre-order I was bit by Luis Suarez at iTunes.
For all the latest updates on the song from Jimmy, go to his Twitter page.
Jimmy impersonator won Butlin's award https://www.jimmycricket.co.uk/wp-content/themes/blade/images/empty/thumbnail.jpg 150 150 mhamer mhamer https://secure.gravatar.com/avatar/e3e9e71d9bef1ab16642587b224d590b?s=96&d=mm&r=g January 16, 2014 January 16, 2014
Jimmy impersonator won Butlin's award
Philip Lewis is on the right of the talent show line-up
Pictures of a young Jimmy Cricket impersonator from the 1980s have been sent to the well-known Northern Irish entertainer.
They were posted to Jimmy at his home in Rochdale just before Christmas and were taken back in 1987 during a Butlin's holiday talent show hosted at the Grand Hotel in Scarborough.
Philip won an award for his impersonation
The focus of the photos are a young man named Philip Lewis who, as a 10-year-old, entered the competition complete with hat and wellies!
It was at a time when Jimmy had several television series on ITV and Philip was dressed up in attire for which Jimmy had become famous.
And Philip did such a great job of impersonating Jimmy that he won an award for it!
Jimmy said: "It was a nice surprise when I opened the letter containing these pictures and a bit of nostalgia crept in as well."
8:30 pm Lyndene Hotel @ Lyndene Hotel
Lyndene Hotel @ Lyndene Hotel
for more information visit their website http://www.lyndenehotel.com/next-tribute-acts/
2:30 pm "No More Fiffing and Faffing" @ Plaza Theatre
"No More Fiffing and Faffing" @ Plaza Theatre
for more information visit their website, here is a link https://stockportplaza.co.uk/whats-on/no-more-fiffing-and-faffing/
Here's a little fun Video about the forthcoming show at the @StockportPlaza1 on Sunday 19th January 2020 at 2.30pm, tickets are £10 concessions £5 🎭 pic.twitter.com/UlpLYsQXnq
@GerryMolumby 😂😂See you soon! x
Prince Harry and Meghan aren't the only ones to go and live in Canada. Wasn't it The Lone Ranger who said to his faithful Indian companion " On to Toronto, Pronto Tonto!"
A Spot of Cricket is Coming to The Plaza! - Totally Stockport totallystockport.co.uk/news/a…
What a great story. twitter.com/STVNews/status…
Cricket Times
Back to Blackpool – then it's the comedy play
The 2020 season begins back at the Lyndene Hotel
Happy New Year from Team @LyndeneHotel
New Year's Eve date at Blackpool's Lyndene Hotel
Jimmy's Archive
Jimmy's Archive Select Month January 2020 December 2019 November 2019 October 2019 September 2019 August 2019 July 2019 June 2019 May 2019 April 2019 March 2019 February 2019 January 2019 December 2018 November 2018 October 2018 September 2018 August 2018 July 2018 June 2018 May 2018 April 2018 March 2018 February 2018 January 2018 December 2017 November 2017 October 2017 September 2017 August 2017 July 2017 June 2017 May 2017 April 2017 March 2017 February 2017 January 2017 December 2016 November 2016 October 2016 September 2016 August 2016 July 2016 June 2016 May 2016 April 2016 March 2016 February 2016 January 2016 December 2015 November 2015 October 2015 September 2015 August 2015 July 2015 June 2015 May 2015 April 2015 March 2015 February 2015 January 2015 December 2014 November 2014 October 2014 September 2014 August 2014 July 2014 June 2014 May 2014 April 2014 March 2014 February 2014 January 2014 December 2013 November 2013 October 2013 September 2013 August 2013 July 2013 June 2013 May 2013 April 2013 March 2013 February 2013 January 2013 December 2012 November 2012 October 2012 September 2012 August 2012 July 2012 June 2012 May 2012 April 2012 March 2012 February 2012 January 2012 December 2011 November 2011 October 2011 September 2011 August 2011 July 2011 June 2011 May 2011
Subscription to Jimmy's Newsletter
7:30 pm "No More Fiffing and Faffing" @ Middlesbrough Theatre
"No More Fiffing and Faffing" @ Middlesbrough Theatre
for more information visit their website, here is a link https://www.middlesbroughtheatre.co.uk/whats-on/
7:45 pm St Patrick's Show @ St Patrick's Primary School
St Patrick's Show @ St Patrick's Primary School
Stockport next for No More Fiffing and Faffing
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Izzy reaches out to Rask with a proposition. Tamara gives Ronald the push he needs to change his life for good. Nick makes a sickening discovery while Izzy executes a devastating plan to decimate Araknet's enemies.
As Araknet celebrates a huge win, Ronald struggles to repair his life before it's too late. The Russians extend a tainted olive branch, causing dissent within the company and throwing Izzy into inner turmoil. Just as Araknet is poised to make a controversial move, an unforeseen enemy strikes.
After Ronald suggests a game-changer for Araknet, he struggles to live up to the team's expectations of him. The Russians hit Araknet hard in an underhanded move, leaving Nick and Izzy to plot swift retaliation.
As ArakNet struggles to best their competitor, Izzy butts heads with the team. Rask recovers, but his murderous past threatens to resurface. Wes, Nick and Mara hustle to bring ArakNet street cred against slim odds. Ronald goes down a dangerous road he's long avoided.
Rask makes a bold move to set things right. After a near-death experience, Izzy reaches out to an old friend. Ronald and Nick rally to Izzy's defense as they rethink the future of their business. The group fears Araknet's baggage will scare off Wes.
After a devastating tragedy, Ronald faces a harrowing decision. Izzy finds herself in hot water after a brazen plan lands her in the Russians' sights. Nick finally grabs Wes's attention with the help of Wes's daughter, Mara.
After a discouraging discovery, the trio forges a new plan. Izzy seeks the help of someone significant from her past. Nick faces a setback while catching a glimpse into the strange world of Wes Chandler. Ronald struggles to get his crew behind the new way of doing business.
Nick has an unexpected encounter with Wes Chandler; Nick has a proposition for Ronald and Izzy; Rask struggles to repair his life; Nick takes on CEO duties.
Nick makes a ruthless deal with Rask; after asking Izzy for help, Ronald is left with limited options to ease the pressures on his gang; Rask gets squeezed by the Russians; Izzy has a breakthrough.
The Morales family mourns Delfia's death; Izzy wants revenge; Rask makes a bargain with Vera; as the new king, Ronald is facing many challenges; Touie comes up with a risky idea.
In the season finale, Nick and Izzy hash out their differences. Nick has an ace up his sleeve, leading to a shocking new ally for GenCoin. Rask is faced with the brutal truth about Alex. The Morales family is blindsided by tragedy.
A struggling GenCoin finds a way to set up shop, but Ronald's plan to put some money in their pockets backfires. An anxious Rask must field questions from his fellow agents. Izzy follows up on an ambitious lead.
Rask is forced clean up his mess. Izzy reaches out to an old classmate and finds a promising lead. Taylor's discovery of Nick's predicament places GenCoin in serious jeopardy. In the face of disaster, Ronald has a burst of inspiration.
As Rask slides into a pit of violence and corruption, he fights to regain control. Nick and Izzy absorb a devastating blow to GenCoin. Ronald takes a risk with the company pitch.
Nick makes the pitch of a lifetime, reviving GenCoin. Rask and Maddie's partnership takes a surprising turn just as Rask forms an unlikely alliance. Ronald gets pulled into a wave of violence with his gang.
Nick, Izzy and Ronald's fundraising is off to a slow start, but Ronald spots an opportunity with a neighborhood VIP. Rask and Maddie catch wind of GenCoin just as Andy tells Nick the truth about Rask. Nick makes a promising business connection.
When Miami tech visionary Izzy Morales fails to attract funding for her new cryptocurrency GenCoin, financier Nick Talman funnels dirty money from his embezzling father. Meanwhile, gangster Ronald Dacey finds his money is missing, while cynical FBI agent Phil Rask hunts for Nick's father.


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