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El Paso Theater
Your independent guide to the best shows in El Paso
OTHER INDIE & ROCK IN EL PASO
Chicano Batman
Enrique Bunbury
ZZ Top Event homeBuy ticketsCustomer reviews Chicano BatmanEnrique BunburyREO Speedwagon
ABRAHAM CHAVEZ THEATRE
Dwight Yoakam (Jan 16, 2021)
Stomp (Apr 20 - 21, 2021)
Mickey Gilley (May 8, 2021)
Brian Culbertson (May 13, 2021)
Gilberto Santa Rosa (Oct 7, 2021)
REO Speedwagon (Nov 10, 2021)
Abraham Chavez Theatre Please selectVenue homeLocation and directionsPre-theatre diningOvernight accommodationSeating maps Dwight Yoakam (Jan 16, 2021)Stomp (Apr 20 - 21, 2021)Mickey Gilley (May 8, 2021)Brian Culbertson (May 13, 2021)Gilberto Santa Rosa (Oct 7, 2021)REO Speedwagon (Nov 10, 2021)
1 Civic Center Plaza, El Paso, TX 79901
Prices from: $75
So distinctive are they, so beyond parody, that it's more like watching some exotic, endangered wildlife than a rock band.
Why See ZZ Top?
Bearded rock wizards ZZ Top ARE ON Tour!
The boys are back with a vengeance, bringing their red-hot blues-rock to you! Influenced by the likes of Johnny Lee Hooker and Muddy Waters, the Rock & Roll hall of famers infuse their classic blues riffs with the spirited, often humorous pursuit of worldly pleasures; look no further for catchy tunes about fast cars, sharp clothes and good times.
The band's sense of humour permeates through their music and onto the stage. Lead vocalist and guitarist Billy Gibbons is charming and self-deprecating, a perfect contrast to the high-energy, fast-paced licks and grooves he creates with bassist Dusty Hill and drummer Frank Beard. Accompanied by stellar lighting design, their high-energy performance is not to be missed!
Performance date: 23 June 2021
And before you stop reading
image: Ralph Arvesen
About El Paso Theater: We are an independent show guide not a venue or show. We sell primary, discount and resale tickets and prices may be above or below face value.
Next available performances
Wed, Jun 23
View all times and dates
10 reviews, average rating: (3.8 Stars)
Anonymous: "As of now best show in town !"
Just like a good vine or cheese , gets better with age ! more
Fido Brown : "ZZ Top Rocks "
The boys rocked like it was the 80s. They played some awesome songs opening... more
Sound good to you? Share this page on social media and let your friends know about ZZ Top at Abraham Chavez Theatre.
Please note: The term Abraham Chavez Theatre and/or ZZ Top as well as all associated graphics, logos, and/or other trademarks, tradenames or copyrights are the property of the Abraham Chavez Theatre and/or ZZ Top and are used herein for factual descriptive purposes only. We are in no way associated with or authorized by the Abraham Chavez Theatre and/or ZZ Top and neither that entity nor any of its affiliates have licensed or endorsed us to sell tickets, goods and or services in conjunction with their events.
El Paso Theater is part of the Theatreland Ltd Collection. Established in 2003, Theatreland offers the largest individual collection of websites providing complete, impartial guides to all the theatrical, musical and performance arts events and venues in the world's greatest theatre cities, from New York's Broadway to London's West End and from the showrooms of Las Vegas to Shakespeare's Globe Theatre.


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Alyson Hurt
Tracking The Money Race Behind The Presidential Campaign
By Sean McMinn & Alyson Hurt • Apr 15, 2019
Raising money isn't just a necessity for candidates hoping to make it through the long and expensive presidential primary process — it's a way to measure candidates' credibility and staying power in a crowded field.
Democrats are dealing with their largest primary pool in at least 40 years, and how they fare in raking in cash could separate the candidates in the pack.
Here are the financial figures that the candidates, including President Trump, have reported to the Federal Election Commission, so far.
Who's Running For President? The 2020 Democrats
By Renee Klahr, Domenico Montanaro & Alyson Hurt • Jan 31, 2019
The Democratic presidential field is big.
Maps Show A Dramatic Rise In Health Insurance Coverage Under ACA
By Alyson Hurt • Apr 14, 2017
New data from the U.S. Census Bureau present the most detailed picture yet of the dramatic rise in the number of people covered by health insurance since the Affordable Care Act went into effect.
County-level data going back to 2010, when the law was signed, show a patchwork of people living without health insurance that ticked down slowly for the first three years under the ACA. But once the online insurance exchanges opened at the end of 2013 and Medicaid expanded, the population living without coverage dropped noticeably.
Oroville Dam Reached Capacity Faster Than Previous 16 Years
By Alyson Hurt • Feb 17, 2017
Since going over capacity last week, the water level in the Oroville Dam has dropped, but it's still at a higher level for this time of year than the previous 16 years.
Sweeping Or Skydiving? When Counting Calories It's All The Same
By Alyson Hurt • Jul 2, 2015
Sure, playing in the women's World Cup burns a lot more energy than watching the women's World Cup. But the number of calories expended in sports and daily activities isn't always so obvious.
To figure it out, we dove into this database compiled by Arizona State University. It charts the energy expenditure for hundreds of activities, from mainstream ("bicycling, leisure, 5.5 mph") to obscure ("caulking, chinking log cabin").
Drinking Too Much? One-Third Of Americans Say Yes
By Alyson Hurt • Jun 3, 2015
"Alcohol use disorder" might not be a hashtag, and there's good reason. The term was created in 2013, when the DSM-5, the bible of mental health diagnoses, ditched the two distinct disorders of alcohol abuse and alcohol dependence in favor of one term: alcohol use disorder.
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Frances Conroy Biography
Biography by Kalsang Published on 07 Jun, 2018 Updated on 07 Jun, 2018
Facts of Frances Conroy
Frances Hardman Conroy
Franny and Frannie
Vincent Paul Conroy
Ossie Hardman
Jan Munroe
View more / View Less Facts of Frances Conroy
Frances Conroy is an American actress popularly known for playing Ruth Fisher in HBO series, Six feet under. She is active in the entertainment industry since 1978 till present and has given some amazing performances in movies, TV series, theatres, and TV films. Conroy is cast in some renowned series like How I Met Your Mother, Desperate Housewives, American Horror Story, Six Feet Under, Grey's Anatomy, and Law & Order among others. She was cast in the 2018 movie, The Tale which aired on 26 May on HBO.
Early Life And Education Of Frances Conroy
Frances Conroy was born Frances Hardman Conroy to parents Vincent Paul Conroy and Ossie Hardman on November 13, 1953. Her father was of Irish descent and worked as a business executive and her mother also worked in business.
CAPTION: Frances Conroy SOURCE: Pinterest
She did her schooling at Dickinson College in Carlisle, Pennsylvania and later moved to New York City to enroll in a drama school named Neighbourhood Playhouse. He also attended Juilliard School. While learning drama in Juilliard she was listed in the Juilliard Drama Division Group 6 with other actors like Harriet Sansom Haris, Kevin Conroy, Robin Williams and Kelsey Grammer.
Frances Conroy's Career
Conroy debuted in the entertainment industry in 1978 with All's Well That Ends Well as Diana and a year later appeared in the feature film Manhattan. In 1982, she debuted in the Television industry with an anthology television series called American Playhouse. Since her debut, Conroy has been cast in several uncountable movies, TV films and TV series. Conroy has also acted in many dramas plays in her career as a theatre artist.
Conroy has been cast in movies since 1979 till present. She did movies like Manhattan, Falling in love, Amazing Grace and Chuck, Rocket Gibraltar, Scent of a Woman, The Neon Bible, Angela, The Crucible and so on in her 20 years of film career. In the recent 2010's she was cast in some movies like Bloodworth, All-star Superman, Welcome to Happiness, No PAY, Nudity, Tom & Jerry: Back to Oz, and The Tale among others. Her recent release is the Amercian drama film, The Tale which premiered on May 26, 2018, on HBO.
Convey has quite the career in Television and has done several TV series like American Playhouse, Kennedy, The Twilight Zone, NewHart, Crime Story, Cosby, Happy Town, Love Bites, Casual, and Getting On among others. However, she is popular for her roles in American Horror Story, Grey's Anatomy, How I Met Your Mother, Desperate Housewives, Six Feet Under, and Law & Order.
Conroy first appeared in a TV film in 1978 with the role of Diana in All's Well That Ends Well. After her debut, she featured in other TV films like The Royal Romance of Charles and Diana, Journey, Thicker than Blood, Murder In a Small Town, and A Perfect Day. Her last film was 2013's Ring of Fire, a biographical television film about the life of June Carter Cash and Johnny Cash.
Conroy first acted in the drama play named Othello as Desdemona. Later on, she acted in multiple dramas acts like The Lady from Dubuque, Painting Churches, Our Town, The Secret Rapture, Ivanov, The Last Yankee, The Little Foxes, The Dinner Party, The Subject was Roses, The Skin of Our Teeth and lots more. She was last seen acting in a drama in 2010 which was The Subject Was Roses, a Pulitzer Price Winning drama written in 1964.
Frances Conroy's Awards And Honors
Conroy has won many awards and has been nominated numerous times till now for her work in the entertainment industry.
Nominated Work Awards Result
1980 Othello Outstanding featured actress in a play(Drama Desk Awards) Nominated
The Last Yankee Outstanding featured actress in a play. (Obie Awards) Won
1994 In the Summer House Outstanding featured actress in a play. (Drama Desk Awards) Nominated
1997 The Rehearsal Outstanding featured actress in a play. (Drama Desk Awards) Nominated
2000 The Ride Down Mt. Morgan Outstanding actress in a play. (Outer critics circle Award)
2002 Six Feet Under
Outstanding performance in a play. (Screen Actors Guild Awards)
2003 Six Feet Under Outstanding actress in a drama. (Screen Actors Guild Awards)
Outstanding featured actress in a series. (Screen Actors Guild Awards)
2012 American Horror Story: Murder House Outstanding featured actress in a play. ( Primetime Emmy Awards) Nominated
2014 American Horror Story: Coven Outstanding featured actress in a play. (Primetime Emmy Awards). Nominated
Frances Conroy's Net Worth
Conroy's estimated net worth is $4 million. She earns her fortune mostly from stage shows, movies, and TV series. For being cast in the popular series How I Met Your Mother, she earned around an estimated $225,000 per episode and for Law & Order, she made $450,000 per episode.
She earned $40,000 per episode for her role in the American Horror Story. She appeared in a total of 35 episodes and made $1,400,000 from the series.
Frances Conroy's Personal Life
Conroy is married to actor Jan Munroe since 1992 and going strong till present. They don't have any children and are happy together. Her favorite famous colleagues are Alyson Hannigan and Burt Lancaster.
Her left eye is different as she suffered from Corneal damage in a car accident. As a result in her eye appears glazed or lighter in color. Her left eye acts different from the other and she uses color lenses to hide her eye condition.
CAPTION: Frances Conroy with husband Jan Munroe SOURCE: Zimbio
Conroy revealed in an interview that she is scared to watch horror movies but she has acted in one.


If you're ready to work with a company that delivers more than just quality, or if you have any questions about our services and pricing, please don't hesitate to call or email us. Our friendly, knowledgeable staff is waiting on the other end! WAGD Garage Door Repair Everett, NH (425) 528-8350 Same Day Service!


This Piece was a finalist in the National Portrait Society's 2015 international portrait competition.
"Life 2" 2012, oil on panel, 34 in. x 14 in.
"Convenient Charity", 2011, oil on canvas, 64" x 40"
"Consumed" 2010, oil on canvas, 96" x 72"
Contact me here to purchase or commission a piece of art, for information about available works, or to learn about my commission process.


Health ministry helps congregations care for one another by attaining, maintaining and/or regaining the best possible whole person health — wellness of body, mind and spirit — that can be experienced. The parish nurse is a registered nurse who is committed to this concept of health ministry.
Parish nurses are licensed, registered nurses who practice wholistic health for self, individuals and the community using nursing knowledge combined with spiritual care. They function in paid and unpaid positions as members of the pastoral team in a variety of religious faiths, cultures, and countries. The focus of their work is on the intentional care of the spirit, assisting the members of the faith community to maintain and/or regain wholeness in body, mind, and spirit. Their practice is governed by the nurse practice act of their state, the Nursing: Scope and Standards of Practice, Faith Community Nursing: Scope and Standards, and the Code of Ethics with Interpretive Statements (for nurses).
Must have an active license in the state in which she/he practices.
Should have specialized knowledge of the spiritual beliefs and practices of the faith community.
Should reflect personal spirituality maturity in her/his practice.


Los Angeles Trip July 2009, originally uploaded by ShashiBellamkonda.
Marinated Breast of Chicken Enchiladas wrapped with Blue Corn Tortillas, Tomatillo Sauce, Sour Cream, and Avocado Garnish. Served with Black Beans and Rice.
Fresh Corn off the Cob, Corn Masa, Cheddar Cheese and Ortega Chile, Steamed in its Own Husk. Beans and Rice.
Delicate Chunks of Chicken Breast.


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Elections board: No recount for Herkimer County Family Court judge race
Donna Thompson
donna@timestelegram.com
If Herkimer County Family Court Judge candidate Mark Rose wants a recount of the ballots cast in last month's Republican primary, he will have to seek it through legal options.
Kim Tranter and Anthony Fumarola, commissioners of the Herkimer County Board of Elections, said in a statement they understood the concerns given the closeness of the race between Rose and Thad Luke. While the race was initially called a tie, a number of missing absentee ballots found after the preliminary certification of the results tipped the race in Luke's favor by five votes.
"The Herkimer County Board of Elections is dedicated to preserving the right to vote and adhering to the policies and procedures prescribed in New York State Election Law," the commissioners said in a statement. "We have consulted with the State Board of Elections and our legal counsel and believe procedures were followed properly. The commissioners are confident in the accuracy of the voting systems and final outcome."
The response comes after a request from Rose sent a letter earlier this week to the Board of Elections and the Herkimer County Legislature seeking a manual recount. The Board of Elections statement was also in response to multiple requests for comment from the Times Telegram.
"A candidate may seek further options and recourse within the judicial system," the commissioners said in the statement.
Rose said he is not surprised that commissioners "failed to act." He previously stated that he does not wish to file a lawsuit.
"This is another black eye given to the voters of Herkimer County," Rose said. "To quote a caller from yesterday's 100.7 FM radio interview, if this doesn't call for a recount, what does?"
Herkimer County Legislature Chairman Vincent J. Bono previously said that while Rose directed his request to the Legislature as well as the Board of Elections, the decision would be up to the commissioners. He said the county attorney had talked with the state attorney at the board of elections, who advised that the decision rested with the local commissioners.


You'll be amazed how we transform your outdoor living area's potential. Greenscape Turf & Design has the vision driven tools and dedicated, talented team that begins and ends with our employees to ensure the success of each project. Customers can count on our staff to provide an attractive and functionally sound landscape that adds beauty and value to your property.


(Ella totally helped me sand her down, remove the hardware and helped roll the first coat of paint on).
and we think she's just gorgeous.
in anticipation of some upcoming FUN photo shoots.
• Lightly sand the entire piece so the paint will stick.
• Wipe down the furniture to remove the dust created from sanding.
• Apply 1st coat of paint. (I prefer using a brush but Ella used a mini roller to help).
• Add hardware back on.
• Apply 2nd coat of paint with brush.
• Let it dry a bit. (I'm pretty impatient so I don't do the whole "let it sit overnight" thing).
• Bring it inside the house and admire.
This is NOT my first "restyle" project.
I've repainted beds, armoires, and various other pieces of furniture in our home.
(I'll have to share those at some point too).
• I didn't let her sit for months before I did something with her. (which can be pretty typical of me).
3 days from the time we brought her home I jumped into the project. Yay me!!
• $6 was all I spent - besides my time - Can't get much better than that.
stating their case for the many reasons why the new furniture should go into their rooms.


Since 1971, Hopelink has served homeless and low-income families, children, seniors and people with disabilities in north and east King County; providing stability and helping people gain the skills and knowledge they need to exit poverty for good. Programs and services focus on nine categories of assistance: Adult Education, Emergency Financial Help, Employment Services, Energy Assistance, Family Development, Financial Literacy, Food Assistance, Housing and Transportation. Hopelink serves about 64,000 people annually.


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User Guide in English
Live View
The Live View interface
Live View Controls
Adjusting focus using the camera's AF system
When a compatible camera is connected for tethered capture, starting Capture One Pro's Live View mode opens a new window with a dedicated workspace that's separate from the main application. The workspace consists of a high-quality viewer, displaying the live view image directly off the camera's sensor, as well as a mix of tools from the main application. In addition, there are several dedicated tools to help accelerate your workflow.
A supported camera can be controlled directly, allowing you to not only adjust a number of exposure settings, but also initiate autofocus and, in some cases, manually adjust the point of focus in small steps. Images are captured directly to the computer, however, as control over focusing is separate from capture, the Live View mode allows you to concentrate on achieving accurate focus without distraction.
When space is at a premium the new workspace can be positioned in front of the main application's workspace or moved (and resized) to a second monitor if desired. Alternatively, the main application's workspace can be minimized, but not closed. In addition to the workspace's high-quality viewer, the Live View window consists of three main user interface elements; the Toolbar, Cursor Tools, and Tool Tabs.
To start Live View, whether you have connected your camera for tethering or not (and you just want to take a look), simply navigate to the Camera tool tab (in the default workspace), go to the Camera tool and click on the Live View button (movie camera icon). Alternatively, navigate to the main menu and click Window -> Live View. The Live View window opens. This window can be moved to a second monitor in a dual-display setup.
NOTE: The Live View mode is not available in Capture One Express.
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Herbert Kappler, né le  à Stuttgart et décédé le  à Soltau est un militaire allemand, officier SS (Obersturmbannführer) et commandant des services secrets et de la Gestapo de Rome, qui organisa en particulier le massacre des Fosses ardéatines.

Le nazisme

Électricien en 1929, il adhére au NSDAP le , à l'âge de 23 ans. Il devient alors Sturmtruppen de la SA, ayant le rang peu élevé de Mann. Il entre ensuite comme Anwärter (candidat) chez les SS, étant officiellement admis le  après six mois d'endoctrinement. En raison de son affiliation antérieure à la SA, il reçoit la chevron d'Honneur de la Vieille Garde dédiée aux membres du Parti nazi ayant adhéré avant l'accession d'Hitler au pouvoir. Il est d'abord assigné à la Allgemeine-SS dans la région de Stuttgart.

En 1935, il fait son service militaire en tant que Schütze, sortant avec le grade de Feldwebel (sergent) de réserve. Volontaire à la Sicherheitspolizei (SD), il est promu Scharführer (sergent) et assigné à des tâches à la Gestapo de Stuttgart, faisant ainsi la rencontre de Reinhard Heydrich. Devenu Oberscharführer, il est envoyé en 1937 en formation à la Führerschule der Sicherheitspolizei de Berlin, sortant Kriminalkommissar. Le , il est promu Untersturmführer (sous-lieutenant) de la Gestapo, étant monté jusqu'au grade de Hauptsturmführer (capitaine) à l'été 1939.

La guerre

Nommé en Pologne où il participe aux Einsatzgruppen, il est ensuite muté en Belgique où il officia pour la Gestapo. Après la conférence de Wannsee, il est chargé de la mise en œuvre de la « solution finale », c'est-à-dire des rafles préalables à la déportation.

Maîtrisant parfaitement l'italien, il est promu officier de liaison de Mussolini grâce à Heydrich, et est chargé du rôle de conseil de la police italienne. Après l'armistice de 1943 entre l'Italie et les Alliés, il est promu Oberbefehlshaber des Sicherheitspolizei und SD, c'est-à-dire chargé de la police secrète SD. Le , il est promu Obersturmbannführer. Avec Otto Skorzeny, il planifie l'évasion de Mussolini.

Début 1944, il devient le plus haut responsable du Reichssicherheitshauptamt (RSHA) à Rome, répondant directement aux directives de la Luftwaffe, dirigée par le général Kurt Mälzer, et du Höherer der SS und Polizeiführer, l'Obergruppenführer Karl Wolff.

Il organise et exécute le massacre des Fosses ardéatines quand il commandait la police militaire allemande à Rome, assisté de son adjoint, le capitaine Erich Priebke, ainsi que du capitaine Karl Hass.

La rafle du Ghetto de Rome

Le , Kappler convoque le rabbin Foà, chef de la communauté juive de Rome, ainsi que le président de la communauté. Il les menace de la déportation de 200 Juifs, sauf à verser une rançon de  d'or.

La rançon de 50 kilogrammes d'or, à laquelle le pape Pie XII ordonna aux services financiers du Saint-Siège de largement participer, ne permit qu'une brève pause. Deux semaines plus tard, le , trahissant la promesse faite au pape,  sont impitoyablement raflés et  d'entre eux sont envoyés à Auschwitz. Seuls 16 d'entre eux survivront.

Kappler est également responsable de la fusillade du ghetto de Rome d'octobre 1943 et des tortures contre les partisans dans la prison de la via Tasso.

Après-guerre

À la fin de la guerre, il est arrêté puis remis aux autorités italiennes en 1947. Il est condamné à la prison à vie. En 1959, l'ancien chef de la SD tant redoutée de Rome, reçoit le baptême catholique en prison, administré par un prêtre, Monseigneur Hugh O'Flaherty. En 1977, il profite d'une hospitalisation pour s'évader en Allemagne, qui alors refuse d'extrader Kappler en Italie ainsi que de le juger. Il meurt l'année suivante à Soltau, en Allemagne.

Références

Liens externes

SS-Obersturmbannführer
Naissance en septembre 1907
Naissance à Stuttgart
Décès en février 1978
Décès en Basse-Saxe
Décès à 70 ans
Agent du Sicherheitsdienst
Membre de la Gestapo
Membre de la SA
Nazi condamné à l'emprisonnement à perpétuité pour crimes de guerre
Mort d'un cancer en Allemagne
Shoah en Italie

redpajama_set_name: RedPajamaWikipedia


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4E-BP2/SH2B1/IRS2 are part of a novel feedback loop that controls β-cell mass
Manuel Blandino-Rosano, Joshua O. Scheys, Margarita Jimenez-Palomares, Rebecca Barbaresso, Aaron S. Bender, Akiko Yanagiya, Ming Liu, Liangyou Rui, Nahum Sonenberg, Ernesto Bernal-Mizrachi
The mammalian target of rapamycin complex 1 (mTORC1) regulates several biological processes, although the key downstream mechanisms responsible for these effects are poorly defined. Using mice with deletion of eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2), we determine that this downstream target is a major regulator of glucose homeostasis and β-cell mass, proliferation, and survival by increasing insulin receptor substrate 2 (IRS2) levels and identify a novel feedback mechanism by which mTORC1 signaling increases IRS2 levels. In this feedback loop, we show that 4E-BP2 deletion induces translation of the adaptor protein SH2B1 and promotes the formation of a complex with IRS2 and Janus kinase 2, preventing IRS2 ubiquitination. The changes in IRS2 levels result in increases in cell cycle progression, cell survival, and β-cell mass by increasing Akt signaling and reducing p27 levels. Importantly, 4E-BP2 deletion confers resistance to cytokine treatment in vitro. Our data identify SH2B1 as a major regulator of IRS2 stability, demonstrate a novel feedback mechanism linking mTORC1 signaling with IRS2, and identify 4E-BP2 as a major regulator of proliferation and survival of β-cells.
https://doi.org/10.2337/db15-1443
10.2337/db15-1443
Fingerprint Dive into the research topics of '4E-BP2/SH2B1/IRS2 are part of a novel feedback loop that controls β-cell mass'. Together they form a unique fingerprint.
Insulin Receptor Substrate Proteins Medicine & Life Sciences
Carrier Proteins Medicine & Life Sciences
Cell Survival Medicine & Life Sciences
Eukaryotic Initiation Factor-4E Medicine & Life Sciences
Janus Kinase 2 Medicine & Life Sciences
Eukaryotic Initiation Factors Medicine & Life Sciences
Blandino-Rosano, M., Scheys, J. O., Jimenez-Palomares, M., Barbaresso, R., Bender, A. S., Yanagiya, A., Liu, M., Rui, L., Sonenberg, N., & Bernal-Mizrachi, E. (2016). 4E-BP2/SH2B1/IRS2 are part of a novel feedback loop that controls β-cell mass. Diabetes, 65(8), 2235-2248. https://doi.org/10.2337/db15-1443
4E-BP2/SH2B1/IRS2 are part of a novel feedback loop that controls β-cell mass. / Blandino-Rosano, Manuel; Scheys, Joshua O.; Jimenez-Palomares, Margarita; Barbaresso, Rebecca; Bender, Aaron S.; Yanagiya, Akiko; Liu, Ming; Rui, Liangyou; Sonenberg, Nahum; Bernal-Mizrachi, Ernesto.
In: Diabetes, Vol. 65, No. 8, 01.08.2016, p. 2235-2248.
Blandino-Rosano, M, Scheys, JO, Jimenez-Palomares, M, Barbaresso, R, Bender, AS, Yanagiya, A, Liu, M, Rui, L, Sonenberg, N & Bernal-Mizrachi, E 2016, '4E-BP2/SH2B1/IRS2 are part of a novel feedback loop that controls β-cell mass', Diabetes, vol. 65, no. 8, pp. 2235-2248. https://doi.org/10.2337/db15-1443
Blandino-Rosano M, Scheys JO, Jimenez-Palomares M, Barbaresso R, Bender AS, Yanagiya A et al. 4E-BP2/SH2B1/IRS2 are part of a novel feedback loop that controls β-cell mass. Diabetes. 2016 Aug 1;65(8):2235-2248. https://doi.org/10.2337/db15-1443
Blandino-Rosano, Manuel ; Scheys, Joshua O. ; Jimenez-Palomares, Margarita ; Barbaresso, Rebecca ; Bender, Aaron S. ; Yanagiya, Akiko ; Liu, Ming ; Rui, Liangyou ; Sonenberg, Nahum ; Bernal-Mizrachi, Ernesto. / 4E-BP2/SH2B1/IRS2 are part of a novel feedback loop that controls β-cell mass. In: Diabetes. 2016 ; Vol. 65, No. 8. pp. 2235-2248.
@article{16cbf3be03e74eaeab9509692b094dae,
title = "4E-BP2/SH2B1/IRS2 are part of a novel feedback loop that controls β-cell mass",
abstract = "The mammalian target of rapamycin complex 1 (mTORC1) regulates several biological processes, although the key downstream mechanisms responsible for these effects are poorly defined. Using mice with deletion of eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2), we determine that this downstream target is a major regulator of glucose homeostasis and β-cell mass, proliferation, and survival by increasing insulin receptor substrate 2 (IRS2) levels and identify a novel feedback mechanism by which mTORC1 signaling increases IRS2 levels. In this feedback loop, we show that 4E-BP2 deletion induces translation of the adaptor protein SH2B1 and promotes the formation of a complex with IRS2 and Janus kinase 2, preventing IRS2 ubiquitination. The changes in IRS2 levels result in increases in cell cycle progression, cell survival, and β-cell mass by increasing Akt signaling and reducing p27 levels. Importantly, 4E-BP2 deletion confers resistance to cytokine treatment in vitro. Our data identify SH2B1 as a major regulator of IRS2 stability, demonstrate a novel feedback mechanism linking mTORC1 signaling with IRS2, and identify 4E-BP2 as a major regulator of proliferation and survival of β-cells.",
author = "Manuel Blandino-Rosano and Scheys, {Joshua O.} and Margarita Jimenez-Palomares and Rebecca Barbaresso and Bender, {Aaron S.} and Akiko Yanagiya and Ming Liu and Liangyou Rui and Nahum Sonenberg and Ernesto Bernal-Mizrachi",
note = "Funding Information: This work was supported by National Institutes of Health (grant nos. RO1-DK073716 and DK084236) and JDRF (grant no. 17-2013-416 to E.B.M.). The authors acknowledge support from the Morphology and Image Analysis Core and the Molecular Biology and DNA Sequencing Core of the National Institutes of Health-funded Diabetes Research Center (NIH P60-DK20572).",
doi = "10.2337/db15-1443",
journal = "Diabetes",
publisher = "American Diabetes Association Inc.",
T1 - 4E-BP2/SH2B1/IRS2 are part of a novel feedback loop that controls β-cell mass
AU - Blandino-Rosano, Manuel
AU - Scheys, Joshua O.
AU - Jimenez-Palomares, Margarita
AU - Barbaresso, Rebecca
AU - Bender, Aaron S.
AU - Yanagiya, Akiko
AU - Liu, Ming
AU - Rui, Liangyou
AU - Sonenberg, Nahum
AU - Bernal-Mizrachi, Ernesto
N1 - Funding Information: This work was supported by National Institutes of Health (grant nos. RO1-DK073716 and DK084236) and JDRF (grant no. 17-2013-416 to E.B.M.). The authors acknowledge support from the Morphology and Image Analysis Core and the Molecular Biology and DNA Sequencing Core of the National Institutes of Health-funded Diabetes Research Center (NIH P60-DK20572).
N2 - The mammalian target of rapamycin complex 1 (mTORC1) regulates several biological processes, although the key downstream mechanisms responsible for these effects are poorly defined. Using mice with deletion of eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2), we determine that this downstream target is a major regulator of glucose homeostasis and β-cell mass, proliferation, and survival by increasing insulin receptor substrate 2 (IRS2) levels and identify a novel feedback mechanism by which mTORC1 signaling increases IRS2 levels. In this feedback loop, we show that 4E-BP2 deletion induces translation of the adaptor protein SH2B1 and promotes the formation of a complex with IRS2 and Janus kinase 2, preventing IRS2 ubiquitination. The changes in IRS2 levels result in increases in cell cycle progression, cell survival, and β-cell mass by increasing Akt signaling and reducing p27 levels. Importantly, 4E-BP2 deletion confers resistance to cytokine treatment in vitro. Our data identify SH2B1 as a major regulator of IRS2 stability, demonstrate a novel feedback mechanism linking mTORC1 signaling with IRS2, and identify 4E-BP2 as a major regulator of proliferation and survival of β-cells.
AB - The mammalian target of rapamycin complex 1 (mTORC1) regulates several biological processes, although the key downstream mechanisms responsible for these effects are poorly defined. Using mice with deletion of eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2), we determine that this downstream target is a major regulator of glucose homeostasis and β-cell mass, proliferation, and survival by increasing insulin receptor substrate 2 (IRS2) levels and identify a novel feedback mechanism by which mTORC1 signaling increases IRS2 levels. In this feedback loop, we show that 4E-BP2 deletion induces translation of the adaptor protein SH2B1 and promotes the formation of a complex with IRS2 and Janus kinase 2, preventing IRS2 ubiquitination. The changes in IRS2 levels result in increases in cell cycle progression, cell survival, and β-cell mass by increasing Akt signaling and reducing p27 levels. Importantly, 4E-BP2 deletion confers resistance to cytokine treatment in vitro. Our data identify SH2B1 as a major regulator of IRS2 stability, demonstrate a novel feedback mechanism linking mTORC1 signaling with IRS2, and identify 4E-BP2 as a major regulator of proliferation and survival of β-cells.
U2 - 10.2337/db15-1443
DO - 10.2337/db15-1443
JO - Diabetes
JF - Diabetes


A large proportion of cancer patients do not enroll in clinical trials, and those who do participate may not adequately represent age groups, cancer stages, cancer types, and racial and ethnic groups. These findings were recently reported in the Annals of Surgery.
Clinical trials are the process through which medications ultimately become approved by the Food and Drug Administration (FDA) in the United States. Clinical trials provide necessary information about drug safety, efficacy, and optimal dose and schedule of treatment.
Research has suggested that for some medications, treatment effects vary by age, ethnicity, or gender. If certain subgroups of the population are under-represented in clinical trials, however, it may be difficult to determine whether this is the case.
To calculate recent patient participation in clinical trials in the United States, researchers reviewed data from 2001–2008 from the California Cancer Registry. Data were evaluated for enrollment in trials for Stage 0–IV solid tumors and included almost 250,000 patients.
Less than one percent of cancer patients enrolled in clinical trials: 0.64% or 1,566 of 244,528.
White patients were more likely to enroll than African-American patients: 0.67% versus 0.48%.
Certain factors were associated with a lower likelihood of participating in trials. These included older age, early-stage cancer, and lung or gastrointestinal cancers.
Under-enrollment was also more common among uninsured and underinsured patients.
Without broader representation of patient characteristics such as age, cancer type and stage, and race or ethnicity, it's uncertain how well trial outcomes can be applied to a broader population. Increased patient participation in clinical trials may produce results that can help more patients. In other words, trials with patient demographics that best match real-world patient populations are likely to be better indicators of a drug's performance.
Reference: Al-Refaie WB, Vickers SM, Zhong W, et al. Cancer trials versus the real world in the United States. Annals of Surgery. September 2011 – Volume 254 – Issue 3 – p 438–443 doi: 10.1097/SLA.0b013e31822a7047.


Detroit's ongoing bankruptcy saga has now taken another turn with the long-awaited release of Emergency Receiver Kevyn Orr's plan of adjustment last week. While considerable attention is understandably being paid to the treatment of creditors and pensioners in the overall plan, it's also important to review how the plan addresses future city government operations-specifically with regard to the privatization of services and assets-as well as proposed reforms to the city's pension system. In two new articles, Reason Foundation analysts explore these issues.
In my latest article, I write that the more services and assets privatized, the more manageable the emergence from bankruptcy and the smoother the path to long-term fiscal and financial sustainability-which translate into improved quality of life for Detroit's citizens and businesses. However, on both fronts-outsourcing and asset privatization-the proposed plan of adjustment is a mixed bag.
In a separate article, my Reason Foundation colleague Anthony Randazzo writes that the history of Detroit's bad actuarial assumptions and its poor operating practices more than make the case for pension reform. The city's plan to "adjust" its $18 billion in debt by slashing as much as half of it before exiting bankruptcy includes cuts to already accrued pension benefits, as well as changes to how future public pension benefits are earned. The proposal also has less innovative, but important elements of good pension reform including forcing the city to use "market values" in accounting for its liabilities, using slightly more realistic investment return assumptions, and adjusting its defined-benefit system. However, while the Detroit plan of adjustment makes some steps towards the needed reform, there is more to do.
New Reason Foundation Pension Reform Case Study on San Jose: Starting in 2010, San Jose embarked on a series of pension reforms that are profiled in a new Reason Foundation case study. These reforms culminated with the passage of Measure B, under which retirement benefits were reduced for new employees, while current employees had to choose between switching to a plan with reduced benefits or contributing more of their salaries in order to maintain their existing benefits. In addition, the measure eliminated the "13th checks" that had been issued in the past when the pension investment fund had earned a return higher than a certain threshold, reduced the automatic annual cost-of-living adjustment from 3 percent to 1.5 percent, and required voters to approve any future benefit increases. With many other cities and states facing large unfunded liabilities for post-employment benefits, San Jose offers one possible model for reform.
Detroit Council Gives Final Approval to Solid Waste Outsourcing: Last week, Detroit's city council gave final approval to two contracts with private waste haulers for residential trash and recycling pickup services that are expected to save taxpayers $6 million annually, according to the Detroit News. The firms will offer positions to current city solid waste workers at a higher pay rate, and the city will avoid an estimated $35 million in costs for new vehicles to replace its aging fleet. "We let the facts drive our decision and […] concluded that the residents of Detroit are better served by turning over trash collection to private contractors better equipped to provide improved and expanded service," according to the city's Chief Operating Officer Gary Brown.
Dallas Exploring Privatized Road Maintenance: Dallas, Texas city manager A.C. Gonzalez is reportedly exploring privatizing the city's street maintenance, according to the Dallas Morning News. Gonzalez recently informed the city council that it was in preliminary discussions with a private infrastructure firm on privatization concepts-including a fixed-cost contract covering all street maintenance services-to stem the city's annually rising costs in maintenance expenditures. "If they could just keep it the same as what we're spending, it's a big win," according to Gonzalez.
Washington State Opens Bulk Printing to Competition: After a lengthy, year-long review, Washington State Gov. Jay Inslee's administration recently announced plans to open up bulk state printing services to private sector competition. State agencies seeking products like business cards, letterhead, brochures, maps, and voter guides will now be able to solicit bids directly from the state's print shop as well as over 350 private printing firms, according to The News-Tribune. The administration also announced plans to review four more state activities for potential outsourcing, including remaining print and imaging functions, website functions, real estate leasing services and vehicle liability claims.
Texas Approves Bundled Maintenance Contract for Houston-Area Highways: Earlier this month, the Texas Transportation Commission approved a two-year, $23 million contract with a private vendor to perform all routine highway maintenance on 350 miles of state-controlled highways-including Interstates, U.S. highways, state highways and farm-to-market roads-within the Beltway 8 loop around Houston. Under the contract, Texas Tree and Landscape, Ltd. will take over a full-scope of routine maintenance functions-encompassing pavements, guardrails, signage, mowing, striping, litter removal and more-at a cost nearly 15 percent lower than the state's, according to Engineering News-Record. The state expects to roll out a number of similar bundled highway maintenance contracts across the state, with anticipated aggregate savings of approximately $96 million over the next five years.
Goldwater Institute Challenges Tucson's Bid Preference Program: Earlier this month, the Arizona-based Goldwater Institute filed a lawsuit challenging a 2012 City of Tucson ordinance that enacted a discriminatory preference for local and state vendors in city contracts for goods and services. Filed on behalf of two Tucson taxpayers and a local business owner, Goldwater is seeking a court order to invalidate the bid preference ordinance as being illegal under state statute and unconstitutional under both the federal and state constitutions. More details on the case and the legal rationale are available here.
University of Kentucky to Pursue Privatized Dining Services: Earlier this month, officials at the University of Kentucky directed its purchasing division to begin negotiations with potential vendors to take over campus dining services in an effort to expand the capacity of dining facilities, as well as lower the cost and improve the quality of dining services offered. Conditions sought by the university include the retention of current dining employees and student workers, the continuation of a current local food purchasing program, and the addition of healthier food choices. The university is also asking bidders to make a capital investment of between $25 million to $50 million to improve and expand dining facilities on the campus in order to avoid taking on new debt, according to the Lexington Herald-Leader. The university received several private proposals in November 2013 after issuing a request for proposals in September.
Maine Announces New Liquor Wholesale Lease: Though categorized as a "control state," Maine has leased the operation of its state-owned liquor wholesale enterprise since 2004. In the summer of 2013, Maine launched a procurement to rebid its wholesale liquor warehousing and delivery operation, and early last month announced that it had selected Pine State Trading Company for a 10-year lease designed to significantly increase revenues to the state relative to the previous 10-year lease agreement. Under the previous wholesale system lease with Maine Beverage Company, the state received an estimated $190 million in revenues over the 10-year contract period, which included a $125 million upfront payment and a share of annual revenues; the new lease agreement is expected to generate up to $450 million in revenue over the next decade, primarily due to shifting from a percentage-based revenue share model to one that pays the contractor a set fee, according to the Bangor Daily News. The administration of Gov. Paul LePage sought the increased revenues to help cover nearly a half million dollars in past Medicaid debts owed to the state's hospitals.
Early Results from the Justice Reinvestment Initiative: A new Urban Institute report developed on behalf of the U.S. Department of Justice's Bureau of Justice Assistance (BJA) offers some early insights into the implementation of the BJA's Justice Reinvestment Initiative (JRI) across 17 states since 2010. The initiative relies on using evidence-based strategies to identify the drivers of prison populations and correctional costs and develop corresponding policies to better manage them while enhancing public safety. Part of the initiative involves reinvesting the cost savings from successful evidence-based programs into more effective public safety measures. According to the report, eight states have already experienced reductions in their prison populations since launching JRI, and it projects cost savings-both from reduced prison populations and avoided capital costs of new prisons-of up to $4.6 billion. The full report-Justice Reinvestment Initiative State Assessment Report-is available here.
-Robert Novy-Marx and Joshua D. Rauh, "Policy options for state pension systems and their impact on plan liabilities," Journal of Pension Economics and Finance, April 2011.


Life on this planet stands at the cusp of a great threshold. As we awaken to the full scale of space and time, we awaken also to our own capacities for altering our planet and ourselves. Now more than ever, do humans need to construct new myths and express a new sense of spirituality.
Religions have always been technologies of belief, protocols for organizing environmental and social interactions. But today's faiths, adapted for ancient agrarian conditions, no longer serve us, and in fact imperil our survival.
New Peace rejects the old dualisms of nature vs. culture and spirit vs. matter, instead fostering a non-dual conception of reality. It is a new protocol to understanding one's place in the vastness of time and space and a toolkit for building new myths and meanings for a world undergoing profound changes. A radically inclusive, secular faith of the real. A mysticism for the anthropocene that fosters a spiritual relationship to matter itself. No divine beings, transcendent realms or eternal essences necessary: only the true in nite creativity of pattern, matter, and energy.
In Campaign for A New Protocol Part I, Si-Qin launches a drive to communicate a new sense of non-dualistic and secular spirituality adapted for the future. Against the backdrop of intricately rendered digital landscapes, New Peace proverbs present a spiritual framework for the world of the contemporary and the future. Here, the natural and the synthetic co- alesce in a space beyond the spirit/matter dualities New Peace seeks to shed.


By Emily Farnworth. - The °Climate Group recently held its first North American members meeting with attendance from over 50 leading businesses, states and cities. The conversation was centered on action from the US on climate change. It was a far-ranging and optimistic conversation with a striking focus on the need for leadership and a robust carbon market.
Many were of the view that although climate change is not on the average American's voting agenda, a new President will provide the opportunity needed to change the rhetoric and open the door for positive discussions to set a carbon emissions reduction target as part of the post-Kyoto process.


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redpajama_set_name: RedPajamaGithub


How much does a textbook weigh today?
The average weight of an individual physics textbook is just over 4.5 pounds (2.04 kg).
Physics and science textbooks tend to be heavier than those of history and geography as there is a need for more illustrations and charts.
The average high school student will carry a bag with textbooks weighing around 16 to 20 pounds (7.25 to 9.07 kg).
This is according to a study carried out by the California Board of Education in 2004.
It is in the 11th grade when the student is carrying the most amount of weight. The weight of the books combined will peak at around 20 pounds.
That is a good amount of weight to be toting around throughout the day.
Chiropractors have expressed concern over the amount of weight that children are carrying on a daily basis. They hear many complaints from children about neck and back pain.
Currently, there is a movement towards digital textbooks as they cost considerably less than paper textbooks and are more environmentally friendly. Not to mention much lighter in weight!
Did you know that the most banned books in the USA are Harry Potter books? This is due to religious complaints.


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Darkroom updated with macOS Monterey support, 'Clarity' feature for Mac, and more
- Oct. 25th 2021 12:02 pm PT
@joseadorno
Alongside the release of macOS Monterey today, the award-winning photo and video editor Darkroom is getting updated to version 5.7 with some new features for the latest version of macOS.
With macOS Monterey release, Darkroom is ready to support Shortcuts on the Mac. In the update's release notes, the team behind Darkroom says:
We're excited to roll out full support for Shortcuts on macOS. This is particularly exciting for us because of all the ways that shortcuts are integrated into Monterey. You can now edit your photos right from Finder, from the menu bar, or from context menus. The full power of Darkroom's editing engine is exposed, including cropping, filters, frames, and more. This works for photos anywhere on your file system, not only those in iCloud Photo Library!
Alongside the Shortcuts feature on the Mac, Darkroom is also adding RAW Smart Album on Monterey and iOS 15. With that, the library sidebar and album selector now lists a RAW Smart Album that collects all of users RAW and RAW+JPEG photos in one place.
Another feature that was exclusive to the iPhone and iPad "due to technical constraints" is finally available with macOS Monterey: Clarity. In a blog post in May, the Darkroom developers explained how this feature works:
Clarity adjusts the contrast within the details of your image, without affecting the overall tone of the image. As you adjust Clarity, the details are either clarified or smoothened, but the whites and blacks remain unaffected, and sharp edges remain sharp.
Apart from these features, there's also deeper keyboard shortcuts integration, zoom improvement, bug fixes, and overall improvements within the app.
Darkroom is available on the App Store for iPhone, iPad, and Mac.
Brazilian tech Journalist. Author at 9to5Mac. Previously at tv globo, the main TV broadcaster in Latin America.
Got tips, feedback, or questions? jose@9to5mac.com


Security Training for NEW or RE-CERTIFYING.
Currently, we are just doing classes as they are needed. If you want to do a class, email us and we will see what we can do.
The Prices listed below are for you to come to our class room in Greenville, SC on a weekday.
We will come to you if the class size and location is discussed and negotiated beforehand.
Remember…if you need SLED Private Security training done right away during the week, we can do it.
This is the bare minimum class you can take.
This class gives you the authority to work as a UN-Armed SLED Private Security Officer. Your Authority will be only to Observe and Report. You Will Not have arrest powers. You wont be allowed to carry handcuffs, a weapon, baton, pepper spray or anything except a whistle and flashlight.
Time: 4 hours / 8:00am – 12:00pm (times are decided by the individual or class).
Again, with this class, you cannot carry a Taser, OC pepper Spray or anything. You will be a SLED Private Security Officer once you get hired by a Private Security Company, but just to Observe and Report.
Primary Basic and Primary Plus taken together WITHOUT Weapons qualifications.
This class gives you the authority to work as a UN-Armed SLED Private Security Officer. Your Authority will be just like a sheriffs deputy on the property you are contracted with EXCEPT you will not carry a Lethal Weapon (handgun). You will be able to carry Pepper Spray, Taser and a Baton when you take this full Primary Plus Course.
Time: 6-8 hours / 8:00am – 4:00pm (times vary per class or individual).
Primary Basic and Primary Plus taken together W / Weapons qualifications.
This class gives you the authority to work as a Armed SLED Private Security Officer. Your Authority will be just like a sheriffs deputy on the property you are contracted with. You Will be a SLED Certified Armed Private Security Officer with this class once you are hired by a company and send your application to SLED. For this class, you must bring the weapon you want to qualify with. If you do not have a weapon, we have them at the range included in our pricing.
Price: $165.00. We supply range, books, weapon, class training.
Email us with questions and we will answer them quickly.
A. Email us and tell us exactly what class you choose.


Capital Centre (Phase 4 Master plan) will be a visionary and spectacular mixed-use community with a variation of indoor and outdoor public spaces designed to seamlessly integrate a balanced mix of uses including office, hotel and residential. Our mission is to create a landmark destination that utilizes the full potential of the site and its location within the emerging City of Abu Dhabi. Our goal is to create the foundation for a fully sustainable community; a place to live, work and shop.
The variation of building heights and the layout of the scheme creates pleasant, usable spaces within a unique public realm that offers places for relaxation, leisure and community.


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Gardner Inlet – wypełniony lodem przesmyk położony na południowo-zachodniej stronie Bowman Peninsula na wschodnim wybrzeżu Ziemi Palmera w południowej części Półwyspu Antarktycznego.

Został odkryty 21 listopada 1947 w trakcie ekspedycji badawczej Finna Ronne (1899–1980) (ang. Ronne Antarctic Research Expedition (RARE)). Częściowo zbadany przez uczestników FIDS-RARE ze Stonington Island w grudniu 1947. Sfotografowany z lotu ptaka w latach 1965–1967 i zmapowany przez United States Geological Survey.

Pierwsza nadana nazwa to American Geographical Society Bay, zmieniona na Gardner Bay, a później na Gardner Inlet dla upamiętnienia fizyka Irvine'a C. Gardnera, którego badania z zakresu optyki zastosowane w aerofotografii były ważnym wkładem w badania polarne.

Przypisy

Półwysep Antarktyczny
Ziemia Palmera


The Brown-Lyons Lecture series explores the many facets of Jewish history, culture and faith and how these shape, are shaped by and intersect with other world traditions, faiths and peoples.
Jack D. Spiro, D.H.L., Ed.D, has long enlightened audiences and fueled community dialogue with his thought-provoking lectures on some of the most important topics in the Jewish culture and faith. This year, he will consult the wisdom of Abraham, Job and philosopher Baruch Spinoza to reflect upon the timeless problem of evil.
In the "catalog" of Jewish beliefs, the concepts of resurrection and immortality may be the least credible to the contemporary mind. But still there are those who accept them not only as acts of faith but as rational prospects. No one has proved or disproved life beyond death. But the idea persists, and the general conviction that death is not the end endures. One thing seems sure: The hope of eternal life crystallizes the teaching of Judaism about the divine worth and character of human personality.
Marni Davis, associate professor of history at Georgia State University, presents her book Jews and Booze: Becoming American in the Age of Prohibition. The book discusses the involvement of Jews in the trafficking of alcohol during Prohibition and how this involvement enflamed anti-Semitism and brought to the surface tensions within the Jewish community over Jewish identity and the interest in full integration into American culture. Doors open at 6:45 p.m. A public reception will follow.
Jonathan D. Sarna, Ph.D., university professor, Joseph H. & Belle R. Braun professor of American Jewish History, and chair of the Hornstein Jewish Professional Leadership Program at Brandeis University, presents his book Lincoln and the Jews: A History. The book details a new aspect of Abraham Lincoln's remarkable relationship with American Jews that impacted both his path to the presidency and his policy decisions as president. Doors open at 6:45 p.m. A public reception will follow.
Rabbi Jill Jacobs, executive director of T'ruah: The Rabbinic Call for Human Rights, speaks about the mission, accomplishments and ongoing efforts of her organization, which mobilizes rabbis, cantors and other concerned American Jews to protect human rights in North America and Israel. She is the author of Where Justice Dwells: A Hands-On Guide to Doing Social Justice in Your Jewish Community and There Shall Be No Needy: Pursuing Social Justice through Jewish Law and Tradition. Doors open at 6:45 p.m. A public reception will follow.


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Cam Newton benched for Jarrett Stidham during poor game
Cam Newton was benched by the New England Patriots for Jarrett Stidham during a poor start on Sunday against the San Francisco 49ers at Gillette Stadium in Foxborough, Mass.
Newton was having a rough
Cam Newton shoulder injury concerns resurface
Cam Newton played miserably in the New England Patriots' loss to the Denver Broncos last week, and he may have been even worse in the first half against the San Francisco 49ers on Sunday. Newto
Cam Newton had great quotes about his performance in Patriots' loss
Cam Newton played his worst game as a New England Patriot in Sunday's loss to the Denver Broncos, and the former NFL MVP is making no excuses for the poor performance.
Newton handled himself ex
Cam Newton, Stephon Gilmore reportedly cleared from coronavirus
It has been less than two weeks since New England Patriots stars Cam Newton and Stephon Gilmore tested positive for the coronavirus, but both are ready to return to practice.
Reports on Wednesday ind
Cam Newton may benefit from Broncos-Patriots being postponed
The New England Patriots are not playing in Week 5 after another member of their organization tested positive for the coronavirus on Saturday. While that is not the ideal scenario for the NFL, it may
Report: Cam Newton has chance to return for Week 5
Cam Newton isn't back in practice, but it sounds like the New England Patriots quarterback still has a chance to return for Monday's game.
Patriots coach Bill Belichick confirmed Saturday
Bill Belichick provides update on Cam Newton's situation
It has been nearly a week since Cam Newton tested positive for the coronavirus, but Bill Belichick says the New England Patriots quarterback is still taking part in preparation for Sunday's gam
Cam Newton shares optimistic message after contracting coronavirus
Cam Newton could potentially miss multiple games after he tested positive for the coronavirus this week, but the New England Patriots quarterback is maintaining a positive attitude.
Newton took to In
Cam Newton tests positive for coronavirus, will not play Sunday
The New England Patriots will not have their starting quarterback on Sunday against the Kansas City Chiefs.
As first reported by ESPN's Adam Schefter, Cam Newton tested positive for COVID-19. H
Bill Belichick heaps more praise on Cam Newton
Bill Belichick certainly seems to be impressed with what he's seeing from quarterback Cam Newton in the early stages of the season.
The New England Patriots coach was full of praise for Newton&
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WKHS Dashboard
Workhorse (WKHS) 8-KWorkhorse Group Reports Third Quarter 2021 Results
Filed: 9 Nov 21, 9:02am
99.1 Workhorse Group Reports Third Quarter 2021 Results
WKHS similar filings
24 Feb 22 Workhorse Group Appoints Bill Quigley to Board of Directors
4 Jan 22 Workhorse Appoints Robert Ginnan as Chief Financial Officer
30 Dec 21 Workhorse Announces Annual Stockholders' Meeting Results
9 Nov 21 Workhorse Group Reports Third Quarter 2021 Results
8 Nov 21 Other Events
4 Nov 21 Unregistered Sales of Equity Securities
3 Nov 21 Entry into a Material Definitive Agreement
WORKHORSE GROUP INC.
Nevada 001-37673 26-1394771
100 Commerce Drive, Loveland, Ohio 45140
Common Stock, $0.001 par value per share WKHS The Nasdaq Capital Market
Item 2.02. Results of Operations and Financial Condition.
On November 9, 2021, Workhorse Group Inc. (the "Company") issued a press release regarding its financial results for the quarter and nine months ended September 30, 2021. The full text of the press release issued in connection with the announcement is furnished as Exhibit 99.1 to this Current Report on Form 8-K.
The information contained in this Item 2.02 shall not be deemed as "filed" for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), or incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such filing.
Item 9.01 Financial Statements and Exhibits.
Press Release dated November 9, 2021
104 Cover page from this Current Report on Form 8-K, formatted as Inline XBRL
Date: November 9, 2021 By: /s/ Gregory T. Ackerson
Title: Gregory T. Ackerson


If you are an EU citizen, and you wish to change your residence, then you need to bring the documents stated below.
written permission from the head of the family that you will be living with, and a photocopy of his/her identity card, if you are going to live with citizens who are already resident.
Depending on your circumstances, you may also have to give extra documentation, as explained below.
original + photocopy of your last 2 pay packets.
- € 11,778.00 or each applicant with 2 or more dependent children under 14 years old.
your dependent direct ancestors (parents, grandparents, etc.) and those of your spouse.
c) certificate of attendance at courses of study, for students.
a spouse joining their already-resident spouse must show their marriage certificate (original or photocopy), translated and authenticated.
the sworn statement of the already-resident family member, declaring that the applicant is dependent on them.
If you have one, your proof of residence (attestazione di soggiorno – the original) issued by the municipality where you lived before.
copy of the authorisation for temporary accommodation, issued by the public housing authority (for those hosted in Public Housing dwellings).
If such documents attesting to the legality of the right to occupy are not produced, the declaration of residency will be inadmissable.
If you wish, you can book an appointment at the counter to change your residence. Click here to make your appointment http://www.comune.vicenza.it/servizi/prenotazioni at the central registry office (ufficio anagrafe centrale) piazza delle Biade, 26.
At District no. 3 – villa Tacchi, viale della Pace 89 – the change of residence service is available only by appointment made online via the above link.
To submit your change of residence application and get informed online of the progress of your application, please visit: Portale del Cittadino – Comune in casa (www.comune.vicenza.it/portaledelcittadino ). To have access to the service, you must register with MyId, the regional authentication system of Veneto Region (you can find all the instructions for completing your MyId registration at: https://www.comune.vicenza.it/servizi/istruzioniaccreditomyid.php ).
4. OR you scan the hand-signed declaration and your identity document and send them by ordinary email.
Under Decree-Law no. 5/2012, residence declarations sent to the Registry office (Ufficio Anagrafe) as stated above are registered by the Registry officer within 2 working days of receipt. From then, the individual residence certificates and family-status certificates can be issued. For all the other certificates – including the identity card – you will need to wait until the municipality where you lived before has sent all your personal details and we have checked that you meet the requirements. You may also have to show suitable documentation, where required. After the residence declaration has been recorded, the Registry officer has to check that your declaration is true and accurate. Someone will come to see you where you live. To facilitate the controls relating to your residency, You must show a copy of the documentation that entitles you to stay there – e.g. a tenancy or lease agreement, or the title deeds.
Because of article 5, paragraphs 4 and 5, of Decree-Law no. 5/2012 and article 75 of Presidential Decree no. 445/2000, if you make false statements, then you will lose the benefits that you gained by making them. This means that your residence will be cancelled, and your situation will return to how it was before. Also, the Registry officer will have to report you to the law-enforcement authorities, because what you told us did not match what we found when we checked.
By article 76 of Presidential Decree no. 445/2000, if you make false statements, then you will be punished under the Criminal code and the relevant special laws.
To access the counter citizens must have a progressive numerical ticket withdrawable to the queue management display in the waiting room for the public, until the available accesses are exhausted. Citizens who proceeded with an online booking of a service, however, are not required to have a ticket, as they access the counter with the reservation number.


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Die Zisterzienserinnenabtei Bondeville war vom 12. Jahrhundert bis 1790 ein Kloster der Zisterzienserinnen in Notre-Dame-de-Bondeville bei Rouen im Département Seine-Maritime in Frankreich.

Geschichte
Das in der ersten Hälfte des 12. Jahrhunderts vom örtlichen Adel sieben Kilometer nördlich Rouen am Fluss Cailly  gestiftete Nonnenkloster Bondeville (auch: Saint-Denis de Bondeville) wurde 1147 als Priorat in den Zisterzienserorden aufgenommen und vom Kloster Bival besiedelt. Die 1170 fertiggestellte Klosterkirche war dem heiligen Dionysius von Paris (Saint Denis) geweiht. Durch weitere Schenkungen und das Wohlwollen der Kaiserin Matilda kam es zu einer förderlichen Entwicklung mit (Mitte des 13. Jahrhunderts) rund 30 Nonnen und 10 Konversen. Die Erzbischöfe von Rouen (u. a. Eudes Rigaud), denen das Kloster unterstand, erhoben es 1657 zur Abtei. Erste Äbtissin war Françoise Le Normand de Beaumont. 1790 kam es durch die Französische Revolution zur Auflösung des Klosters und zum Abbau der Gebäude. In Notre-Dame-de-Bondeville sind nur noch archäologische Spuren erhalten. Die Straßennamen Rue de l'Abbaye, Rue des Bernardines, der Gemarkungsname Bois de l'Abbaye und der Gebäudename L'Abbaye (modernes Gebäude des Konzerns Sanofi) erinnern an das einstige Kloster.

Literatur
 Alain Alexandre: Notre-Dame-de-Bondeville. A. Sutton, Saint-Cyr-sur-Loire 2004. 127 Seiten (Ortsgeschichte).
 Alain Alexandre: Du prieuré de Notre dame de Bondeville au laboratoire Choay. Généalogie d'un site de la Vallée du Cailly. Etablissements Choay. Notre-Dame de Bondeville 1983.
 Armelle Bonis und Monique Wabont (Hrsg.): "Cisterciens et Cisterciennes en France du Nord-Ouest. Typologie des fondations, typologie des sites". In: Cîteaux et les femmes, hrsg. von Bernadette Barrière und Marie-Élizabeth Henneau. Créaphis, Paris 2001, S. 151–175 (Rencontres à Royaumont, 15).
 The register of Eudes of Rouen. Hrsg. von Jeremiah F. O'Sullivan. Columbia University Press, New York 1964 (darin mehrere Visitationsberichte über das Kloster Bondeville).

Handbuchliteratur
 Laurent Henri Cottineau: Répertoire topo-bibliographique des abbayes et prieurés. Bd. 1. Protat, Mâcon 1939–1970. Nachdruck: Brepols, Turnhout 1995. Spalte 419.
 Bernard Peugniez: Le Guide Routier de l'Europe Cistercienne. Editions du Signe, Straßburg 2012, S. 265.
 Gereon Christoph Maria Becking: Zisterzienserklöster in Europa. Kartensammlung, Lukas Verlag Berlin 2000, ISBN 3-931836-44-4, Blatt 53 C.

Weblinks
 "Bondeville" in Cistopedia - Encyclopaedia Cisterciensis
 Eintrag auf der Website der Certosa di Firenze
 Seite im Zisterzienserprojekt des Fotografen Carsten Gier
 Archivseite mit Klostergeschichte, Äbtissinnenliste und Literatur, französisch
 Kurze Klostergeschichte, französisch, bebildert
 Historische Abbildung des Klosters
 Archäologische Information zum Kloster, französisch
 Kartularienseite des Klosters

Bondeville
Bondeville
Aufgelöst 1790
Bondeville
Organisation (Département Seine-Maritime)
Bondeville


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UK Government bows to pressure to set out government plan for leaving EU
British Prime Minister, Theresa May, has agreed to publish a "white paper" setting out HM Government's plans for Brexit in greater detail. According to an article in the Financial Times, Mrs May said she accepted there was an "appetite" for such a document after Tory MPs stepped up the pressure on her to set out a written plan for Brexit. Downing Street had last week played down the need for a white paper, arguing that Mrs May's speech at Lancaster House a week ago provided sufficient clarity on her plans for leaving the EU. Following yesterday's Supreme Court ruling that the government must hold a parliamentary vote before starting the UK's two-year exit from the EU, former business minister Anna Soubry, stated that "They [the government] will be in genuine difficulties on the Article 50 motion if they try and thwart the genuine desire to have a proper debate". The legislation setting out the government's plan will be published tomorrow on Thursday 26 January 2017 in the form of a bill. Mrs May indicated that she wanted to push the bill through the House of Commons and the House of Lords by the middle of March, allowing her to maintain her original timetable of triggering Brexit by the end of that month.


While many football-loving artists are preoccupied with showing only the glitz and the glamour of life on and off the pitch, capturing a player's good side and playing up to their polished reputations, illustrator Daryl Rainbow is one who remains perfectly content to buck that trend at every opportunity.
Far more aroused by the anarchy the sport often inspires, and the foibles of those at its centre, who find themselves inexplicably catapulted into stardom despite being wholly unprepared for such a role, Daryl's work seeks not to represent the players as stars but remind us all that the stars are always only human.
Daryl recently chatted to These Football Times to discuss the origins of his keenly recognisable art style, why he focuses on the facets of football so many of his contemporaries seek to shun, the players that most stand out from his childhood of falling in love with the game, and much more.
What are your earliest memories of football and do you believe these memories inspired you to draw the game in the way you do today?
"My earliest memories of football are of the great late-90s Arsenal team. I loved the rivalry between Arsenal and Manchester United; the fights between Vieira and Keane. I remember the intensity of those matches, being excited throughout the week waiting for the match on Saturday. As I child I remember being fascinated by those games, but at the same time having massive anxiety watching it.
"I think what made me fall in love with the Premier League was the brilliant characters each team had back then, it was like Eastenders to me. Each club had so many great personalities; from the inspirational captains to the elegant flair players, to the bruising hard men. And they all had their flaws, which I think is why they were so interesting. They were well-rounded characters, with their own demons, rather than the sort of two-dimensional, slightly dull, perfect role model footballers you have in the Premier League now.
In addition to being, at times, a little caricaturish, I hope you'd agree your style presents players in a way that is cruder and rather less polished than many illustrators seek to. Is this in any way a representation of your opinion on football – a case of you drawing players the way you view them – or is it more just the natural result of the subject matter colliding with your own style of drawing?
"I suppose with my work, outside of the football illustrations, I've always been interested in flawed characters and situations and I guess that also shows with my football illustration. The flawed characters always have more engaging personalities. Whether they be the hot-heads, cheaters, the prima donnas or the players suffering from addictions.
Beyond the everyday actions of a football game, your drawings tend to take on a wider narrative quality and depict players performing actions for which they eventually became famous or, as is often the case, infamous off the pitch. Is this intentional and if so why? What makes those moments more memorable in your eyes?
"Focusing on the slightly negative side of the footballers, I suppose, is intentional. I think those big controversies in the game – from Zidane's headbutt to Rivaldo's dive, to the addictions of the 90s Arsenal players – are just as important as a magnificent volley that wins a final. I think those controversies make people fall in love the game just as much if not more than the glorious moments. People remember and talk about those moments just as much.
What do you usually look for in a subject or a scene to draw? Furthermore, who is your favourite footballer to draw?
What are your ambitions for this season? What would be your dream commission?
Thanks to Daryl Rainbow for speaking to These Football Times as part of The Gallery. If you're an artist for whom football remains the ultimate muse, and you'd like to feature in The Gallery, please email us with examples of your work.


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A Possible Replacement For Your Daily Pill?
Intarcia is developing a yearly implant that may be able to replace daily type 2 oral medications.
Intarcia Therapeutics, a Boston-based biotech startup, has been working on creating a new type 2 diabetes treatment that could replace the need for a daily pill. Development started in 2012 and the company has recently started to make plans to file for FDA approval.
The drug is designed to help control high blood sugar levels, but will not be an oral medication like many of the type 2 drugs currently on the market. Intarcia's drug is contained in a matchstick-sized osmotic pump that is implanted during a one-minute outpatient procedure. Rather than having to take a pill every day, this pump will provide continuous treatment for up to one year.
In a preliminary trial of 535 type 2 diabetes patients, the researchers claim those on Intarcia's drug nearly doubled glucose reductions and more than tripled weight loss in comparison to patients using Januvia.
The company is planning on filing for FDA approval in early 2016 and is hoping to release the drug by mid-2017.
Would you be interested in trying a new drug of this type? Share with the community in the comment section below.


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Harlan "Hal" Wygant
Retired from the banking world. Served three years in Army Security Agency in Tokyo, Japan. Recently remarried at age 80. Loves writing, crafts, golf and cooking. Has already published two novels; Junkyard Dog and Samurai Conspiracy. Gideon's Chariot (available in paperback and eBook) is the third of the trilogy.
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By Harlan Wygant
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Published: FriesenPress - March 27th, 2013
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This sequel to "The Junkyard Dog" takes place five years later. Brad Logan is now a homicide captain and must stop a gang of terrorists who have killed several prominent citizens. When Brad's wife is kidnapped by the gang, the hunt becomes more personal. When he becomes reckless in his investigation, he is suspended and must continue on his own.
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Published: iUniverse - December 1st, 2001
‹ Ernie Zarra, Ph.D. up Heather James ›


text:
Ultraleggero è un singolo del cantante italiano Gianni Morandi pubblicato l'11 maggio 2018 come terzo estratto dal suo quarantesimo album in studio D'amore d'autore.

Video musicale
Il videoclip, diretto da Gaetano Morbioli, è stato pubblicato il 28 maggio 2018 sul canale Vevo-YouTube del cantante.

Note

Collegamenti esterni


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© Copyright 2007 Luxology LLC. Modo, imageSynth and Nexus are trademarks of Luxology LLC., in the USA and/or other countries. All products or brand names mentioned are trademarks or registered trademarks of their respective holders.
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How do you ensure validity in a summative assessment?
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Reliability refers to the extent to which an assessment method or instrument measures consistently the performance of the student. Assessments are usually expected to produce comparable outcomes, with consistent standards over time and between different learners and examiners.
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Validity is commonly understood as referring to the outcomes of an assessment and whether the evidence known about the assessment supports the way in which the results are used. Test users need to be sure that the particular assessment they are using is appropriate for the purpose they have identified.
They are what every psychometrician AND teacher need to know and understand. When psychometricians build large scale tests for state departments of education, there's a list of validity and reliability concerns that they need to address.
In order for assessments to be sound, they must be free of bias and distortion. Reliability and validity are two concepts that are important for defining and measuring bias and distortion. Reliabilityrefers to the extent to which assessments are consistent.
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A Mothers Ramblings: Top Ender Giggles - Even I knew that!
Earlier this week, on one of the nights I was working, Daddy decided that an extended walk was in order for him and Baby Boy to help them both keep out of my way.
Daddy put Baby Boys sleep suit on and a fleece sleep suit on top and put a blanket over the top of that. Over the top of this was the rain covers as it was drizzling.
Daddy then set off on the walk.
Five minutes later a very wet Daddy returned with an asleep Baby Boy.


London smog in winter seems an unlikely inspiration for a painter but the impressionist Claude Monet came three times to the capital for extended visits to see the fog change the light patterns over the Thames.
He returned to France to finish a series of more than 30 paintings, not exhibiting them until 1904; insisting that they should all be seen at once to get the full effect. Sadly with a price tag for just one painting now above £10 million they are unlikely to be seen together again, and since diesel fumes do not have the same magical effect, we are never likely to be able to repeat his experience.
The critics thought the paintings "pure art" and compared Monet to Turner. Satisfied, Monet turned to painting water lilies – something for which he is now better known.


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2017 Outstanding Informal Education Award | Jonathan Frederick
Jonathan Frederick Wins Award for Work with the NC Science Festival
RESEARCH TRIANGLE PARK, N.C. – Jonathan Frederick, the director of the North Carolina science Festival has been awarded the North Carolina Science, Mathematics, and Technology Education Center's award for informal science education excellence. Mr. Frederick will be recognized at the SMT Center's gala on April 29 in Raleigh, N.C.
The annual award recognizes an outstanding educator in informal STEM education (science, technology, engineering, and mathematics) in North Carolina.
"Mr. Frederick is a driven and passionate educator," said CEO and President of the SMT Center Dr. Sam Houston. "He is just as curious and engaged in the learning process as the students he is teaching."
In 2011 Mr. Frederick was named the director of the North Carolina Science Festival, the first statewide festival of its kind in the nation. The Festival is a multi-day celebration showcasing science and technology. The festival highlights the educational, cultural, and financial impact of science in our state. The Festival provides hands on activities, lab tours, nature experiences, exhibits, and performances and engages a wide range of public audiences. This 2017 Festival had more than 700 events attended by hundreds of thousands of North Carolinians. And for the first time, Festival events were held in all 100 North Carolina counties.
Mr. Frederick began his career in Tampa as an educator at the Florida Aquarium. In 2001 he moved to North Carolina to develop the first residential environmental education program in North Carolina State Park history. Most recently he served as the science programs manager at the Morehead Planetarium and Science Center.
Mr. Frederick is a graduate of Penn State University, receiving his bachelor's degree in biology.
The N.C. Science, Mathematics, and Technology (SMT) Center is focused on improving education as a means of providing all students in North Carolina with the knowledge and skills to have successful careers, be good citizens, and advance the economy of the state. Promoting innovation and change in education, the SMT Center celebrates educational excellence in North Carolina by supporting educators, engaging students, and advancing the growing importance of having a STEM-educated workforce.
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Posted on August 13, 2013 by catsynth	This entry was posted in Art, Photography, Travel, Wordless Wednesday and tagged architecture, Art, hipstamatic, industrial southeast, pdx, Photography, portland, railroad, Travel, Wordless Wednesday. Bookmark the permalink.
Hipstamatic from the Southeast Industrial section of Portland. I recalled this area from my band tour in 2007, and made time the past weekend to explore it in more detail.
That is such a neat picture. I love seeing train tracks. It is fun looking down the tracks. Great picture.
A nicely composed, moody image!
I agree with the others, this is really evocative.
So industrial, yet somehow very "quiet." Nice capture!
I like what seems to be a red filter ring around the center of the photo but probably is just the natural light. And I always enjoy anything related to trains because my dad is a model railroader.
Like this – like the lines of the tracks leading into the distance! Cool shot.
I love looking at your pics; I'm also glad I don't live in those places!
Found you through Twitter and now following your lovely blog via Bloglovin. Have a lovely day.
Actually, my neighborhood in San Francisco is a bit like this. Or rather, was like this. Earlier rounds of gentrification still left a lot of industrial flavor and grit, but the latest round of redevelopment threatens to erase what is left.


Asheville is one of the fast growing towns that has taken up the challenge of maintaining its identity while engulfing itself with smart growth. It may be a top destination for many people but for many new comers and old timers alike, the dream destination may be found in its surrounding areas which still offer cheaper housing options while still giving a mountain like experience for urban dwellers.
While acknowledging this well balanced act, Jonathan believes that the area is buzzing with entrepreneurs and millennial who have so much to offer to the area.
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