Welcome to the web site and online service of Soca Foods, Inc. d/b/a Soca, ("Soca Foods, Inc.," "we," "our," or "us").
You can use the Service only if you can form a binding contract with Soca Foods, Inc., and only in compliance with this Agreement and all applicable local, state, national, and international laws, rules and regulations. Any use or access to the Service by anyone under 18 is strictly prohibited and in violation of this Agreement. The Service is not available to any Users previously removed from the Service by Soca Foods, Inc.
Your Soca Foods, Inc. account gives you access to the services and functionality that we may establish and maintain from time to time and in our sole discretion. We may maintain different types of accounts for different types of Users. If you open a Soca Foods, Inc. account on behalf of a company, organization, or other entity, then (a) "you" includes you and that entity, and (b) you represent and warrant that you are an authorized representative of the entity with the authority to bind the entity to this Agreement, and that you agree to this Agreement on the entity's behalf. By connecting to the Service with a -party service, you give us permission to access and use your information from that service as permitted by that service, and to store your log-in credentials for that service.
You may never use another User's account without permission. When creating your account, you must provide accurate and complete information. You are solely responsible for the activity that occurs on your account, and you must keep your account password secure. We encourage you to use "strong" passwords (passwords that use a combination of upper and lower case letters, numbers and symbols) with your account. You must notify Soca Foods, Inc. immediately of any breach of security or unauthorized use of your account. Soca Foods, Inc. will not be liable for any losses caused by any unauthorized use of your account.
You may control your User profile and how you interact with the Service by changing the settings on the personal settings page associated with your Soca Foods, Inc. account. By providing Soca Foods, Inc. your email address you consent to our using the email address to send you Service-related notices, including any notices required by law, in lieu of communication by postal mail. We may also use your email address to send you other messages, such as changes to features of the Service and special offers. If you do not want to receive such email messages, you may opt-out or change your preferences on the personal settings page associated with your Soca Foods, Inc. account. Opting out may prevent you from receiving email messages regarding updates, improvements, or offers.
You are solely responsible for your interactions with other Users. We reserve the right, but have no obligation, to monitor disputes between you and other Users. Soca Foods, Inc. shall have no liability for your interactions with other Users, or for any User's action or inaction.
You agree not to engage in any of the following prohibited activities: (i) copying, distributing, or disclosing any part of the Service in any medium, including without limitation by any automated or non-automated "scraping"; (ii) using any automated system, including without limitation "robots," "spiders," "offline readers," etc., to access the Service in a manner that sends more request messages to the Soca Foods, Inc. servers than a human can reasonably produce in the same period of time by using a conventional on-line web browser; (iii) transmitting spam, chain letters, or other unsolicited email; (iv) attempting to interfere with, compromise the system integrity or security or decipher any transmissions to or from the servers running the Service; (v) taking any action that imposes, or may impose at our sole discretion an unreasonable or disproportionately large load on our infrastructure; (vi) uploading invalid data, viruses, worms, or other software agents through the Service; (vii) collecting or harvesting any personally identifiable information, including account names, from the Service; (viii) using the Service for any commercial solicitation purposes; (ix) impersonating another person or otherwise misrepresenting your affiliation with a person or entity, conducting fraud, hiding or attempting to hide your identity; (x) interfering with the proper working of the Service; (xi) accessing any content on the Service through any technology or means other than those provided or authorized by the Service; or (xii) bypassing the measures we may use to prevent or restrict access to the Service, including without limitation features that prevent or restrict use or copying of any content or enforce limitations on use of the Service or the content therein.
Accessing the audiovisual content available on the Service for any purpose or in any manner other than Streaming is expressly prohibited. "Streaming" means a contemporaneous digital transmission of an audiovisual work via the Internet from the Service to a User's device in such a manner that the data is intended for real-time viewing and not intended to be copied, stored, permanently downloaded, or redistributed by the User.
From time to time, we may offer and/or co-sponsor contests, sweepstakes, raffles, promotions and games on the Service. Each of these activities may be governed by specific rules listed below. By participating in any such activities, you will become subject to those rules and we urge you to read any applicable rules. To the extent that the terms and conditions of such rules conflict with this Agreement, the terms and conditions of such rules shall control.
Some areas of the Service allow Users to post content such as profile information, comments, questions, images, and other content or information. Any content or information a User submits, posts, displays, links to, or otherwise makes available on the Service is referred to as "User Content." We claim no ownership rights over User Content created or provided by you. The User Content you create remains yours; however, by sharing User Content through the Service, you agree to allow others to view, edit, and/or share your User Content in accordance with your settings and this Agreement. Soca Foods, Inc. has the right (but not the obligation) in its sole discretion to remove any User Content that is shared via the Service.
By posting or otherwise making available any User Content on the Service, you hereby expressly grant, and you represent and warrant that you have all rights necessary to grant, to Soca Foods, Inc. a royalty-free, sublicensable, transferable, perpetual, non-exclusive, worldwide license to use, reproduce, modify, publish, list information regarding, edit, translate, distribute, syndicate, publicly perform, publicly display, and make derivative works of all such User Content and your name, voice, and/or likeness as contained in your User Content, in whole or in part, and in any form, media or technology, whether now known or hereafter developed, for use in connection with the Service and Soca Foods, Inc.' (and its successors' and affiliates') business, including without limitation for promoting and redistributing part or all of the Service (and derivative works thereof) in any media formats and through any media channels. You also hereby grant each User of the Service a non-exclusive license to access your User Content through the Service, and to use, reproduce, modify, distribute, display and perform such User Content as permitted through the functionality of the Service and under this Agreement.
You agree not to post User Content that: (i) may create a risk of harm, loss, physical or mental injury, emotional distress, death, disability, disfigurement, or physical or mental illness to you, to any other person, or to any animal; (ii) may create a risk of any other loss or damage to any person or property; (iii) seeks to harm or exploit children by exposing them to inappropriate content, asking for personally identifiable details or otherwise; (iv) may constitute or contribute to a crime or tort; (v) contains any information or content that we deem to be unlawful, harmful, abusive, racially or ethnically offensive, defamatory, obscene, infringing, invasive of personal privacy or publicity rights, harassing, humiliating to other people (publicly or otherwise), libelous, threatening, profane, or otherwise objectionable; (vi) contains any information or content that is illegal (including, without limitation, the disclosure of insider information under securities law or of another party's trade secrets); (vii) contains any information or content that you do not have a right to make available under any law or under contractual or fiduciary relationships; or (viii) contains any information or content that you know is not correct and current.
You agree that any User Content that you post does not and will not violate third-party rights of any kind, including without limitation any Intellectual Property Rights (as defined below) or rights of privacy. To the extent that your User Content contains music, you hereby represent that you are the owner of all the copyright rights, including without limitation the performance, mechanical, and sound recordings rights, with respect to each and every musical composition (including lyrics) and sound recording contained in such User Content and have the power to grant the license granted below.
In connection with your User Content, you affirm, represent and warrant the following: (i) you have the written consent of each and every identifiable natural person in the User Content to use such person's name or likeness in the manner contemplated by the Service and this Agreement, and each such person has released you from any liability that may arise in relation to such use; (ii) your User Content and any use thereof as contemplated by this Agreement and the Service will not violate any law or infringe any rights of any third-party, including but not limited to any Intellectual Property Rights and privacy rights; (iii) Soca Foods, Inc. may exercise the rights to your User Content granted under this Agreement without liability for payment of any guild fees, residuals, payments, fees, or royalties payable under any collective bargaining agreement or otherwise; and (iv) to the best of your knowledge, all your User Content and other information that you provide to us is truthful and accurate.
Soca Foods, Inc. reserves the right, but is not obligated, to reject and/or remove any User Content that Soca Foods, Inc. believes, in its sole discretion, violates these provisions. You understand that publishing your User Content on the Service is not a substitute for registering it with the U.S. Copyright Office, the Writer's Guild of America, or any other rights organization. Soca Foods, Inc. takes no responsibility and assumes no liability for any User Content that you or any other User or third-party posts or sends over the Service. You shall be solely responsible for your User Content and the consequences of posting or publishing it, and you agree that we are only acting as a passive conduit for your online distribution and publication of your User Content. You understand and agree that you may be exposed to User Content that is inaccurate, objectionable, inappropriate for children, or otherwise unsuited to your purpose, and you agree that Soca Foods, Inc. shall not be liable for any damages you allege to incur as a result of User Content.
Except for your User Content, the Service and all materials therein or transferred thereby, including, without limitation, software, images, text, graphics, illustrations, logos, patents, trademarks, service marks, copyrights, photographs, audio, videos, music, and User Content belonging to other Users (the "Soca Foods, Inc. Content"), and all Intellectual Property Rights related thereto, are the exclusive property of Soca Foods, Inc. and its licensors (including other Users who post User Content to the Service). Except as explicitly provided herein, nothing in this Agreement shall be deemed to create a license in or under any such Intellectual Property Rights, and you agree not to sell, license, rent, modify, distribute, copy, reproduce, transmit, publicly display, publicly perform, publish, adapt, edit or create derivative works from any Soca Foods, Inc. Content. Use of the Soca Foods, Inc. Content for any purpose not expressly permitted by this Agreement is strictly prohibited.
Subject to the terms and conditions of this Agreement, you are hereby granted a non-exclusive, limited, non-transferable, freely revocable license to use the Service for your personal, noncommercial use only and as permitted by the features of the Service. Soca Foods, Inc. reserves all rights not expressly granted herein in the Service and the Soca Foods, Inc. Content (as defined below). Soca Foods, Inc. may terminate this license at any time for any reason or no reason.
You may choose to or we may invite you to submit comments or ideas about the Service, including without limitation about how to improve the Service or our products ("Feedback"). By submitting any Feedback, you agree that your disclosure is gratuitous, unsolicited and without restriction and will not place Soca Foods, Inc. under any fiduciary or other obligation, and that we are free to use Feedback without any additional compensation to you, and/or to disclose the Idea on a non-confidential basis or otherwise to anyone. You further acknowledge that, by acceptance of your submission, Soca Foods, Inc. does not waive any rights to use similar or related ideas previously known to Soca Foods, Inc., or developed by its employees, or obtained from sources other than you.
Purchases from Soca Foods, Inc.
From time to time, Soca Foods, Inc. may offer products for purchase through the Service ("Products"). We reserve the right to refuse any order you place with us. We may, in our sole discretion, limit or cancel quantities or Products purchased per person, per household or per order. These restrictions may include orders placed by or under the same account, the same credit card, and/or orders that use the same billing and/or shipping address. In the event that we make a change to or cancel an order, we may attempt to notify you by contacting the email, billing address and/or phone number provided at the time the order was made. We reserve the right to limit or prohibit orders that, in our sole judgment, appear to be placed by dealers, resellers or distributors.
You must be 18 years of age or older to purchase any Products from Soca Foods, Inc.
All payments through the Service are processed using a third-party processor. You acknowledge that Soca Foods, Inc. is not liable for any breaches of credit card or debit card security or privacy by such third-party processor. You agree to pay all charges incurred by users of your credit card, debit card, or other method of payment.
Soca Foods, Inc. will ship all Products purchased through the Service to the address specified in the shipping address section of the order form. Shipments will be made via standard ground service unless otherwise specified at the time of purchase. The time period from order to delivery will vary depending on location. You may have Products shipped only to addresses located within the United States.
Don't love your Soca? Soca Foods, Inc. stands behind our product and will do our best to make it right. If you are dissatisfied with one of our Products for any reason, Soca will refund the amount paid for your most recent order, limited to one 12 pack. To request a refund or replacement send an email to team@socafood.com with your name, order confirmation number, and reason for the request, within 30 days of when you receive your product. We may require proof of purchase if we can't verify your order. If needed we will adjust this policy as required by the laws of the state in which you live. Because of food safety laws we unfortunately can't accept the return of food products.
If the product you received was damaged in transit or is otherwise defective, we will replace it with a similar version of the product at no cost to you. If the product doesn't agree with you we will (at our discretion) refund your order. Refund policy subject to change without notice.
You may cancel your subscription to Products offered through the Service at any time. If there is an outstanding order associated with your subscription, the cancellation will go into effect once that order is processed by Soca Foods, Inc.
You understand that Products may contain materials that could be dangerous if handled improperly, and you acknowledge that Soca Foods, Inc. is not liable for any personal injury or property damage arising from any misuse of any Products offered through the Service. You further acknowledge that you expressly assume sole liability for providing any individual under the age of 18 with access to any Products. You hereby agree not use Products for any illegal purpose and you assume all liability for any action you take for any action that is contrary to any law, rule, or regulation of any territory.
When you place a Subscription Program order, Soca Foods, Inc. will automatically place and ship that same order on the same day every month.
Please note that any coupons will only be applied to your first month's subscription.
The credit card you used to place your initial Subscription Program order will be charged until you cancel your Subscription Program order, or modify your credit card information. Subsequent orders will be charged the day the order is placed and forwarded to the warehouse for processing.
If your credit card is declined at the time of a Subscription Program order placement, your order will not be placed; you will be notified that your Subscription Program payment has failed and you will need to update your credit card information. Once your payment information is corrected, your Subscription Program order will be processed. To update your credit card information, you can go to your "My Account" section and click the "Edit" link next the last four digits of your credit card information on the desired Subscription Program.
The initial Subscription Program period is roughly 30 days, with the same order being shipped on the same day of every month as your initial order. If this date falls on a Sunday or Holiday, it will be processed on the next business day. If your order falls on a date that the following month does not have (example: 31st), your order will be processed on the next business day.
Subscription Program shipments will be of the same Product or Products ordered during the initial Subscription Program shipment. You may change the Product or Products received as part of your Subscription Program at any time by logging into your account, going to your "My Account" section, and clicking "Update subscription." You may also email us at team@socafood.com with your name, Subscription Program number, and the desired Product or Products change. Pricing may change depending on the changes to the Subscription Program order Product or Products.
If you find you have a surplus of Soca you can postpone your subscription anywhere from 1 to 8 weeks by logging into your account, going to your "My Account" section, and clicking "Postpone shipment". You can also email us at team@socafood.com with your name, Subscription Program number, and a description of which Product or Products you'd like to pause and for how long.
You may cancel your subscription to Products offered through the Subscription Program at any time. If there is an outstanding order associated with your subscription, the cancellation will go into effect once that order is processed by Soca Foods, Inc.
Through your online account by logging your account, going to your "My Account" section, and clicking "Cancel" on the desired Subscription Program.
Emailing us at team@socafood.com. In your email you must include your name, Subscription Program number, and what Product or Products you would like to cancel. Please note that response times may exceed 48 hours.
Soca Foods, Inc. is committed to constantly innovating its Soca Products and from time to time will update a Product's or Products' formula. In the event of such an update, your Subscription Program order will continue as before except that the Product or Products will be replaced with the new formula Product or Products. You will not be notified separately of this change before a subsequent Subscription Program order is processed and shipped. The new formula Product or Products will continue on subsequent Subscription Program orders unless you choose to remove this item from your Subscription Program order.
Soca Foods, Inc. cares about the integrity and security of your personal information. However, we cannot guarantee that unauthorized third parties will never be able to defeat our security measures or use your personal information for improper purposes. You acknowledge that you provide your personal information at your own risk.
Please note that this procedure is exclusively for notifying Soca Foods, Inc. and its affiliates that your copyrighted material has been infringed. The preceding requirements are intended to comply with Soca Foods, Inc.' rights and obligations under the DMCA, including 17 U.S.C. §512(c), but do not constitute legal advice. It may be advisable to contact an attorney regarding your rights and obligations under the DMCA and other applicable laws.
In accordance with the DMCA and other applicable law, Soca Foods, Inc. has adopted a policy of terminating, in appropriate circumstances, Users who are deemed to be repeat infringers. Soca Foods, Inc. may also at its sole discretion limit access to the Service and/or terminate the accounts of any Users who infringe any intellectual property rights of others, whether or not there is any repeat infringement.
You agree to defend, indemnify and hold harmless Soca Foods, Inc. and its subsidiaries, agents, licensors, managers, and other affiliated companies, and their employees, contractors, agents, officers and directors, from and against any and all claims, damages, obligations, losses, liabilities, costs or debt, and expenses (including but not limited to attorney's fees) arising from: (i) your use of and access to the Service, including any data or content transmitted or received by you; (ii) your violation of any term of this Agreement; (iii) your violation of any third-party right, including without limitation any right of privacy, right of publicity or Intellectual Property Rights; (iv) your violation of any applicable law, rule or regulation; (v) your User Content or any that is submitted via your account; or (vi) any other party's access and use of the Service with your unique username, password, or other appropriate security code.
THE SERVICE AND PRODUCTS ARE PROVIDED ON AN "AS IS" AND "AS AVAILABLE" BASIS. USE OF THE SERVICE OR PRODUCTS IS AT YOUR OWN RISK. TO THE MAXIMUM EXTENT PERMITTED BY APPLICABLE LAW, THE SERVICE AND PRODUCTS ARE PROVIDED WITHOUT WARRANTIES OF ANY KIND, WHETHER EXPRESS OR IMPLIED, INCLUDING, BUT NOT LIMITED TO, IMPLIED WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, OR NON-INFRINGEMENT. WITHOUT LIMITING THE FOREGOING, Soca Foods, INC, ITS SUBSIDIARIES, AND ITS LICENSORS DO NOT WARRANT THAT THE CONTENT IS ACCURATE, RELIABLE, OR CORRECT; THAT THE SERVICE WILL MEET YOUR REQUIREMENTS; THAT THE SERVICE WILL BE AVAILABLE AT ANY PARTICULAR TIME OR LOCATION, UNINTERRUPTED OR SECURE; THAT ANY DEFECTS OR ERRORS WILL BE CORRECTED; OR THAT THE SERVICE IS FREE OF VIRUSES OR OTHER HARMFUL COMPONENTS. ANY CONTENT DOWNLOADED OR OTHERWISE OBTAINED THROUGH THE USE OF THE SERVICE IS DOWNLOADED AT YOUR OWN RISK AND YOU WILL BE SOLELY RESPONSIBLE FOR ANY DAMAGE TO YOUR COMPUTER SYSTEM OR MOBILE DEVICE OR LOSS OF DATA THAT RESULTS FROM SUCH DOWNLOAD OR YOUR USE OF THE SERVICE.
Soca Foods, INC DOES NOT WARRANT, ENDORSE, GUARANTEE, OR ASSUME RESPONSIBILITY FOR ANY PRODUCT OR SERVICE ADVERTISED OR OFFERED BY A third-party THROUGH THE SERVICE OR ANY HYPERLINKED web site OR SERVICE, AND Soca Foods, INC WILL NOT BE A PARTY TO OR IN ANY WAY MONITOR ANY TRANSACTION BETWEEN YOU AND THIRD-PARTY PROVIDERS OF PRODUCTS OR SERVICES.
TO THE MAXIMUM EXTENT PERMITTED BY APPLICABLE LAW, IN NO EVENT SHALL Soca Foods, INC, ITS AFFILIATES, AGENTS, DIRECTORS, EMPLOYEES, SUPPLIERS, OR LICENSORS BE LIABLE FOR ANY INDIRECT, PUNITIVE, INCIDENTAL, SPECIAL, CONSEQUENTIAL, OR EXEMPLARY DAMAGES, INCLUDING WITHOUT LIMITATION DAMAGES FOR LOSS OF PROFITS, GOODWILL, USE, DATA, OR OTHER INTANGIBLE LOSSES, THAT RESULT FROM THE USE OF, OR INABILITY TO USE, THIS SERVICE OR ANY PRODUCTS. UNDER NO CIRCUMSTANCES WILL Soca Foods, INC BE RESPONSIBLE FOR ANY DAMAGE, LOSS, OR INJURY RESULTING FROM HACKING, TAMPERING, OR OTHER UNAUTHORIZED ACCESS OR USE OF THE SERVICE OR YOUR ACCOUNT OR THE INFORMATION CONTAINED THEREIN.
TO THE MAXIMUM EXTENT PERMITTED BY APPLICABLE LAW, Soca Foods, INC ASSUMES NO LIABILITY OR RESPONSIBILITY FOR ANY (I) ERRORS, MISTAKES, OR INACCURACIES OF CONTENT; (II) PERSONAL INJURY OR PROPERTY DAMAGE, OF ANY NATURE WHATSOEVER, RESULTING FROM YOUR ACCESS TO OR USE OF OUR SERVICE OR PRODUCTS; (III) ANY UNAUTHORIZED ACCESS TO OR USE OF OUR SECURE SERVERS AND/OR ANY AND ALL PERSONAL INFORMATION STORED THEREIN; (IV) ANY INTERRUPTION OR CESSATION OF TRANSMISSION TO OR FROM THE SERVICE; (V) ANY BUGS, VIRUSES, TROJAN HORSES, OR THE LIKE THAT MAY BE TRANSMITTED TO OR THROUGH OUR SERVICE BY ANY third-party; (VI) ANY ERRORS OR OMISSIONS IN ANY CONTENT OR FOR ANY LOSS OR DAMAGE INCURRED AS A RESULT OF THE USE OF ANY CONTENT POSTED, EMAILED, TRANSMITTED, OR OTHERWISE MADE AVAILABLE THROUGH THE SERVICE; AND/OR (VII) USER CONTENT OR THE DEFAMATORY, OFFENSIVE, OR ILLEGAL CONDUCT OF ANY third-party. IN NO EVENT SHALL Soca Foods, INC, ITS AFFILIATES, AGENTS, DIRECTORS, EMPLOYEES, SUPPLIERS, OR LICENSORS BE LIABLE TO YOU FOR ANY CLAIMS, PROCEEDINGS, LIABILITIES, OBLIGATIONS, DAMAGES, LOSSES OR COSTS IN AN AMOUNT EXCEEDING ONE DOLLAR.
THIS LIMITATION OF LIABILITY SECTION APPLIES WHETHER THE ALLEGED LIABILITY IS BASED ON CONTRACT, TORT, NEGLIGENCE, STRICT LIABILITY, OR ANY OTHER BASIS, EVEN IF Soca Foods, INC HAS BEEN ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. THE FOREGOING LIMITATION OF LIABILITY SHALL APPLY TO THE FULLEST EXTENT PERMITTED BY LAW IN THE APPLICABLE JURISDICTION.
The Service is controlled and operated from its facilities in the United States. Soca Foods, Inc. makes no representations that the Service is appropriate or available for use in other locations. Those who access or use the Service from other jurisdictions do so at their own volition and are entirely responsible for compliance with all applicable United States and local laws and regulations, including but not limited to export and import regulations. You may not use the Service if you are a resident of a country embargoed by the United States, or are a foreign person or entity blocked or denied by the United States government. Unless otherwise explicitly stated, all materials found on the Service are solely directed to individuals, companies, or other entities located in the United States.
This Agreement, and any rights and licenses granted hereunder, may not be transferred or assigned by you, but may be assigned by Soca Foods, Inc. without restriction. Any attempted transfer or assignment in violation hereof shall be null and void.
You agree that: (i) the Service shall be deemed solely based in California; and (ii) the Service shall be deemed a passive one that does not give rise to personal jurisdiction over Soca Foods, Inc., either specific or general, in jurisdictions other than California. This Agreement shall be governed by the internal substantive laws of the State of California, without respect to its conflict of laws principles. The application of the United Nations Convention on Contracts for the International Sale of Goods is expressly excluded. You agree to submit to the personal jurisdiction of a state court located in Los Angeles County, California or the United States District Court for the Southern District of California, for any actions for which we retain the right to seek injunctive or other equitable relief in a court of competent jurisdiction to prevent the actual or threatened infringement, misappropriation or violation of our copyrights, trademarks, trade secrets, patents, or other intellectual property or proprietary rights, as set forth in the Arbitration provision below.
For any dispute with Soca Foods, Inc., you agree to first contact us at team@socafood.com and attempt to resolve the dispute with us informally. In the unlikely event that Soca Foods, Inc. has not been able to resolve a dispute it has with you after attempting to do so for a period of sixty (60) days, we each agree to resolve any claim, dispute, or controversy (excluding any Soca Foods, Inc. claims for injunctive or other equitable relief) arising out of or in connection with or relating to this Agreement, or the breach or alleged breach thereof (collectively, "Claims"), by binding arbitration by the American Arbitration Association ("AAA") in the city of Los Angeles, California under the commercial rules then in effect for the AAA, except as provided herein. The award rendered by the arbitrator shall include costs of arbitration, reasonable attorneys' fees and reasonable costs for expert and other witnesses, and any judgment on the award rendered by the arbitrator may be entered in any court of competent jurisdiction. Nothing in this Section shall be deemed as preventing Soca Foods, Inc. from seeking injunctive or other equitable relief from the courts as necessary to protect any of Soca Foods, Inc.' proprietary interests.
ALL CLAIMS MUST BE BROUGHT IN THE PARTIES' INDIVIDUAL CAPACITY, AND NOT AS A PLAINTIFF OR CLASS MEMBER IN ANY PURPORTED CLASS ACTION, COLLECTIVE ACTION, PRIVATE ATTORNEY GENERAL ACTION OR OTHER REPRESENTATIVE PROCEEDING. THIS WAIVER APPLIES TO CLASS ARBITRATION, AND, UNLESS WE AGREE OTHERWISE, THE ARBITRATOR MAY NOT CONSOLIDATE MORE THAN ONE PERSON'S CLAIMS. YOU AGREE THAT, BY ENTERING INTO THIS AGREEMENT, YOU AND Soca Foods, INC ARE EACH WAIVING THE RIGHT TO A TRIAL BY JURY OR TO PARTICIPATE IN A CLASS ACTION, COLLECTIVE ACTION, PRIVATE ATTORNEY GENERAL ACTION, OR OTHER REPRESENTATIVE PROCEEDING OF ANY KIND.
Soca Foods, Inc. may provide notifications, whether such notifications are required by law or are for marketing or other business related purposes, to you via email notice, written or hard copy notice, or through posting of such notice on our web site, as determined by Soca Foods, Inc. in our sole discretion. Soca Foods, Inc. reserves the right to determine the form and means of providing notifications to our Users, provided that you may opt-out of certain means of notification as described in this Agreement. Soca Foods, Inc. is not responsible for any automatic filtering you or your network provider may apply to email notifications we send to the email address you provide us.
This Agreement, together with any amendments and any additional agreements you may enter into with Soca Foods, Inc. in connection with the Service, shall constitute the entire agreement between you and Soca Foods, Inc. concerning the Service. If any provision of this Agreement is deemed invalid by a court of competent jurisdiction, the invalidity of such provision shall not affect the validity of the remaining provisions of this Agreement, which shall remain in full force and effect.
No waiver of any term of this Agreement shall be deemed a further or continuing waiver of such term or any other term, and Soca Foods, Inc.' failure to assert any right or provision under this Agreement shall not constitute a waiver of such right or provision.
Please contact us at team@socafood.com with any questions regarding this Agreement.


Kaduna State government yesterday said it has abolish the operation of independent waste collectors in Kaduna, Kafanchan and Zaria and anyone caught henceforth will be dealt with accordingly.
This was also as the state government said it is engaging the service of 1,500 graduates who will in turn engage 10 other persons to effectively manage wastes in the state.
Speaking on behalf of Governor Nasir El-Rufai at a press briefing in Kaduna on Wednesday, Director of Environment, the State's Ministry of Environment and Natural Resources, Ahmed Saliu, said those still interested must registered with ZL Global Alliance which is key contractor engaged by the state government to manage waste in the state.
He added that the major reasons for the development are to check security, creates gainful employment for graduates and increase internally generated revenue for the state.
"The government has already met with independent waste collectors some of whom have been doing it for quite a long time. They were made to understand that their operation is lopsided and have been advised to register with ZL Global Alliance.
"We are also using the opportunity to check security because we need to know who is doing what and this can be done when everyone involved is fully registered. Henceforth, it is a crime for any company to operate as private and not through ZL Global Alliance in managing waste in Kaduna, Kafanchan and Zaria and anyone found culpable will be sanctioned accordingly", he said.
Also speaking, Managing Director, ZL Global Alliance, Abiola Bashorun, hinted that some individuals have been going round the state illegally to collect waste levy running into millions every month without remitting anything into the state government pause.
She further said that her company will commence house to house waste collection simultaneously come December 1st, 2016 ahead of termination of the first phase of the contract which is 31st of December 2016.
According to her, "We are bringing in smaller company on board including the independent waste collectors. Some of them have been there since 1984. We are saying they should come and register with us as they were told when the Governor and other State executive council members met with them recently.
"What we are doing is transparent and that is why why are working under close supervision of Kaduna State Internal Revenue Service (KADIRS) and Ministry of Environment and Natural Resources. We are moving with minimum of wheelbarrow and maximum of compacting trucks.
"That means no private organization or individual is permitted to collect any waste collection levy/fee on behalf of the state government apart from the recognized ZL Global Alliance.
"We are going to employ 1,500 graduates who indigenes of the state in all out franchise areas who will also engage ten others of lower education cadre to work under them.
"Waste to cash initiative is not dead. We want to look at from other way round. For instance, if we can be doing it once a month where as in environmental day and people after sweeping and clearing their premises especially those in the market place and stand by their waste, we can then come to evacuate and compensate them", she explained.


Bathrooms are used for a variety of essential means – washing, bathing, storing items – and your bathroom cabinet is very likely to be one of the most-used storage solutions in the entirety of your home. To this end, Casanad have worked hard to put together a varied catalogue of affordable and top quality corner bathroom cabinets and wall mounted cabinet solutions to benefit a wide range of interior designs and looks. From small oak bathroom cabinets to dark wood bathroom floor cabinets, we have a comprehensive collection of looks and styles which we think will look fantastic in modern and more ornate vintage-inspired bathroom suites alike. Whether you like the idea of a white wall mounted bathroom cabinet or a simple, small bathroom cabinet to house your essential bits and pieces, you'll be spoilt for choice when you buy online with Casanad.
Wide bathroom storage cabinets, slim white bathroom cabinets and more besides – neutral looks, expansive space or inconspicuous storage solutions – it's all a matter of choice, and that choice is down to you. Bathroom cabinets store an awful lot of essential items. They can be home to medicines, toiletries, creams and soaps – which means that, if you already have a fair amount collected, you may need a bigger space to put everything in! High slim bathroom cabinets are a great idea if you need to keep certain items out of reach of little ones – while glass corner bathroom cabinets and spectacular glossy black bathroom cabinets add an extra shimmer and shine to a space which you should really make all your own.
We work with leading and trusted suppliers and specialists to put together a brimming catalogue full of high quality homeware ideas at a low cost. We love saving our customers money, but at the same time, our focus is on providing consistently high quality furniture and homewares for day to day use. White freestanding bathroom cabinets or wooden bathroom cabinets created and carved in a certain style – the choice is ultimately yours. If you already have a themed or outlandish bathroom or washroom space which you'd like to dress up a little more, count on our online store and buy with us. Small freestanding bathroom cabinets and bathroom storage solutions which blend into minimalist designs and monochrome colour schemes are available, too. We don't offer cheap bathroom cabinets and ideas – we offer top quality, luxury bathroom cabinets at the best prices around.
At Casanad, we can help you to kit out and dress up each and every room in your home with ease. Why settle for cheap items elsewhere when you can feasibly afford luxury for less? Here to help homes with tightened household budgets gain access to opulent and great-looking designs from room to room and from floor to floor, let Casanad be your local ally in homewares, furniture and storage solutions alike. Stuck for ideas? Call our team now on 0203 795 1021.


Never before has there been a cover to enter central park or for it to be exclusive but Tavern on the Green will change all that thanks to the assistance of club owner JE Englebert.
Uhhhh, come again? And a "cover to enter central park [sic]" is meant to be a good thing?


Throughout 2016 and 2017 Manta Ray Bay Resort & Yap Divers is offering a 30th anniversary special!
Location Yap is best-known for it's resident manta ray presence, clear blue water diving and a strong reef shark population.
With almost 100 miles of barrier reef, several big channels and lagoon sites, there is one of everything here to explore - miles of outer reef wall diving, deep and shallow channels to drift as well as inner lagoon macro and night diving.
Instructors & Dive masters Owner is Bill Acker. PADI Open Water Instructor #34545, TDI Enriched Air Instructor #1919, SSI Platinum Pro 5000 Member. Bill founded Yap Divers in July 1986 and has pioneered the dive industry in Yap ever since. Most of the dive sites of Yap were personally discovered and named by Bill and he is always looking for new and better diving for his guests. With over 12,000 logged dives, most of them here in Yap, you can be sure that you are diving with an experienced professional...Continue reading when you dive with Bill. He regularly dives with the guests and continues to enjoy discovering new sites and new critters. Bill is proud of what he has built at Yap Divers. It is the best equipped, most experienced dive shop around and has an impeccable safety record.
John Pekailug. Born on Lamotrek Atoll in the State of Yap on the 31st of January, 1962. Graduated from Outer Island High School. Learned to dive with Yap Divers in August of 1993 as a dive shop summer hire. Has worked with Yap Divers since then and has logged more than 7,500 dives in and around Yap. Few, if any, people know Yap better than John. Not only an excellent diver but also very personable and a leader among the staff. Regularly mentioned as one of our top dive guides.
Alex Raimon. Born on Satawal in Yap State on the 17th of July, 1963. Graduated from Pohnpei Agricultural & Trade School (PATS) and learned to dive at Yap Divers in February of 1991 and has worked with Manta Ray Bay Resort & Yap Divers ever since. The most experienced dive guide, Alex also speaks fluent Japanese as well as fluent English. He has upwards of 8,000 dives and has explored several of Yap's most famous dive sites. Alex's popularity is legendary as evidenced by the numerous cards and letters received from past guests.
Nicholas "Nico" Erhieisap. Born on Satawal Island on the 1st of May, 1965. Graduated from Outer Island High School on Ulithi Atoll in May 1984. Attended Palau Community College and studied business. Nico learned to dive with Yap Divers in 1996 and currently has over 7,000 dives around the island of Yap. Nico makes up 1/2 of the "A Team", along with Bill Acker, for his uncanny ability to find the manta rays on every dive.
Gordon Keiji. Born in Yap on the 25th of November 1970 and graduated from Yap High School in 1988. Began working in the hospitality industry immediately after school. His first job was as a jack of all trades for the Alphonso Family, owners of the ESA Hotel. In June of 1997 Gordon moved to Beyond the Reef dive shop and was a dive guide for them until he had to leave work in early 2006 to take care of his parents. Tragically, Gordon's mom passed away but his father has made vast improvements allowing Gordon to resume doing what he does best – scuba diving. Gordon came to Yap Divers on Halloween of 2006 and has quickly become one of our most dependable guides. He has over 3,000 dives in and around the reefs of Yap.
Tony. Born on Yap October 17th, 1971. Tony started diving with us in 2012 and has over 2000 dives. He was previously working at Wa'ab Construction.
Kintu. Born on Satawal Island February 1st 1975 and graduated Yap Outer Island High School in 1993. Kintu has been guiding with us since 2006 with over 4000 dives. Previously he was a guide in Palau with Sea World Dive Center.
Mike. Born in Yap September, 1971 and graduated Yap High School in 1985. Mike started diving with us in 2009 and has over 3000 dives.
Charles. Born in Woleai Atoll on January 9th, 1975 and graduated at Woleai Elementary School in 1989. Charles has been diving Yap since 2009 and has over 4000 dives.
Equipment Description The Manta Ray Bay Resort was built FOR divers, BY divers. Our harborside dive center, Yap Divers, has everything you'd expect from a PADI 5-star facility, and so much more. Yap Divers is a full-service facility with modern boats, rental gear, dive shop, camera bays, gear rinse and storage. Yap Divers dives all sites around Yap on a daily basis with up to 5 dives per day offered to our guests.
Plus, at the end of an unforgettable day of diving, it's nice to know that ...Continue readingthere are only a few dozen steps or so from the quay to your room or the bar aboard the S/V Mnuw, our 100 year old South Seas Schooner.
The dive center is equipped with three (3) fresh water rinse tanks for dive gear and two (2) dedicated fresh water camera rinse tanks. Our rinse tanks are even lighted at night so that you won't misplace any gear! Adjacent to the rinse tanks is a fresh water shower to rinse the salt off of your skin and a drying area to hang your gear to dry.
Each diving guest has their own, marked gear bay to store all of their dive gear.
No need to take your cameras back to your room! The dive center is equipped with 6, locking camera bays. Each camera bay has an adjustable, magnifying lamp and locked storage compartment. And for added security, the dive center is locked each night for your added peace of mind. But, rest assured that there is almost no crime in Yap to begin with.
Our tanks and rental equipment are up to the same high standards. We don't like rusty, banged-up tanks and gear that's falling apart, so we use nothing but the best. We even have our own hydrostatic testing machine to insure the safety of each and every tank.
Our gear rental comes from ScubaPro and is completely replaced each November with entirely new gear.
We offer Nitrox diving, a great way to go since most of the diving here is ideal for Nitrox. If you would like to try but lack Nitrox certification we offer both TDI and PADI courses.
Fleet of 8 fast, modern, twin engine dive boats ranging in size from 21 to 38 feet allows to accommodate any individual needs, from private charters to fun packed group trips.
All boats carry radio, oxygen and emergency medical kits for safety and boat drivers know every nook and cranny of the reefs by heart.


t x 8....for a total of 39 for 269.
Ifeel like I have done this one before.
Anyone have a total for this one?
If it starts with i, then I have it too.
I like that "i" 7!!
how many points is the 9?
Wow, 32 words starting with X so far. This is fun!
how many letters in the Y word?
I'm completely stuck on 134 for 1412, has anyone got more than this?
any clues for the 9???????
Has to do with having fame or prestige... I'm terrible with clues.
Perfectly good clue, runningforhome - thanks!
thanks for the good clue runningforhome!
There's an alternate spelling of a certain drug for 6/33, and its plural for 7/48.
Kirsty1 - how the hell have you managed to find so many S and T words?
Nah, I'm just home alone today so I've spent more hours on it than is stricly healthy! I don't even know what most of the S and T words are - there are some mad ones that I just got through trial, error and then more error!
stor and stoor are perfectly good words - i checked them - but it won't accept them.
Particularly annoyed by "stoor", its a good scots word. Anyone else had these rejected?
I had the 'st' words rejected as well.
Dictionary certainly doesn't know all.
the only drug I can find in there is an 'e' short... and I'm fixed and stuck on in. any clues on other drugs?
ConXshun, you're on the right track with that drug.
That's the drug I keep trying to make too. Driving me nuts! I should not have started this puzzle. Don't have time to play, but can't keep it out of my mind.
Uggh! Just keep trying end letters where you're missing the E and you'll find it. Who knew?
thanks for the further drug clues! have succeeded :) and yeah - who would've thought eh?
I've got 6s for 27, 33, 24, 18, 18, 18 (in alph. order). What have you all got?
I'm missing two of the 18s, but I have one for 24 ahead of the 27.
Wow, 32 words starting with X so far. This is fun!"
Between ~2AM and ~8AM there were some starting letter counts posted. Some of the categories have more than you listed. There are around 134 words in this puzzle.
I'm fairly sure that was a joke.
Has anyone used the X within a word?
still can't find the drug word. i'm giving up in disgust!
I am stuck at 49.
it's not peyote so what is it?
Anyone got more than 2 I's??
Drug word starts with P.
what the next letter in the nine letter "N" word?
i do not know what the second letter is.
the next letter is "e"
is there even a word with nine letters starting with "N"
you will be able to get.
yes it is the n in the firs column.
Not doing as well today. That bleeping N9 is driving me crazy!
Anyone have a hint for the 7 letter i word?
Has to do with chemistry and the periodic table.
you could go to an online thesaurus, if that helps.
Sorry to not have responded earlier. I got offline not to long after that bit of playing I did.


text:
Crewe Alex: Alex face Luton with loan signing Church
LOAN signing Simon Church is praying for an instant impact in tomorrow's vital clash with Luton Town.
Peter Morse
The 18-year-old striker joined on a month's loan from Premiership side Reading last night and will be immediately thrust into the limelight.
The Wales U21 international will partner fellow loan star Lee Barnard in attack, and said: 'The club has a great history so I'm looking forward to the challenge. I am really excited. I have been playing reserves this year and was on the bench in the Carling Cup.
'I have been waiting all my life for top level football and hopefully I'll take my chance. I aim to work hard, score goals, link the play and get on the ball and cause some damage.
'I want to do well for the club and show I can play at this level. I don't feel any pressure. I am sure all the boys want to work hard and do well. I'm ready.'
The teenager, who has been at Reading since the age of 14, is known as an all-round player rather than one to rely on a particular attribute.
Alex assistant Neil Baker was impressed as he watched Church score for Wales U21s against Malta in midweek, and he comes highly recommended by Royals boss Steve Coppell.
Aside from long-term injury victims Nicky Maynard and Stuart Tomlinson, the Alex have a fully-fit squad to choose from for the visit of the Hatters, who beat Northampton 4-1 on Monday night.
Crewe FC
Opinion: Crewe Alex must break more than one pattern when Bury visit
Crewe Alexandra FCThe verdict on another blank on the road

redpajama_set_name: RedPajamaCommonCrawl


text:
NYU #1 in "Open Doors" Survey for 5th Straight Year
NYU ranks first among US universities for both international students and study abroad five years in a row.
The core of New York University is the academic enterprise. The best students and faculty are drawn to the University by the allure of being part of a compelling intellectual and creative enterprise — a community of scholars characterized by collaboration, innovation, and incandescent teaching. NYU students get the experience of attending a truly global university, anchored in New York City but with nodes throughout the world. Learning opportunities present themselves both in and out of the classroom, befitting an institution that is and always has been "in and of the city". And now our students and faculty are global citizens, exposed to culture, students, faculties and research opportunities throughout the world.
Tap Into Your Academic Resources
Start to construct your academic plans to achieve your career and life goals.
Course descriptions are now available from the search results page. Click on the course number to view the details.
Get your transcripts, grades and verification.
Undergraduate Advisement
Advisors in your school - both faculty and staff - are experts in their chosen profession, ready to help you navigate your academic life.
NYU Classes
Access course materials, collaborate with others, complete assessments and assignments, and track your grades.
Beyond Washington Square Lies a World of Opportunity
As a student in a global network university with campuses in Abu Dhabi and Shanghai as well as 11 global academic centers, you're able to make progress toward your degree on five continents.
NYU Study Abroad Programs >
13 total slides
Located in the cultural and political center of the United Arab Emirates.
Visit Abu Dhabi
Offering courses in the arts, literature, communication, journalism, media, anthropology, history, politics, global public health, and sociology taught by local professors and visiting faculty from New York.
Visit Accra
Experience a cosmopolitan city that holds a complex and crucial place in modern European history.
An exceptional and intimate learning community in one of the world's great cosmopolitan cities.
Visit Buenos Aires
Take advantage of the extraordinary cultural resources provided by the city of Florence.
Visit Florence
Live and learn in the heart of Bloomsbury, a neighborhood that is home to the British Museum, the Royal Academy of Dramatic Art, and the West End (London's famous theatre district).
Visit London
A modern, cosmopolitan city, in the center of the Iberian peninsula and a convenient point of departure from which to explore the entire country.
Visit Madrid
Study in the Latin Quarter, the thriving historic and intellectual heart of Paris.
A broad curriculum in art, architecture, film, media, music, photography, politics, business, the humanities, and social sciences in one of the world's most beautiful cities.
Visit Prague
The third degree-granting campus in NYU's global network, offering a study away option for students interested in a semester or year studying in this exciting business and cultural center.
Visit Shanghai
Providing students the unparalleled opportunity to live and study in a hub of commerce, culture, and communication in the Asia-Pacific region.
Visit Sydney
Experience life in one of the world's most intriguing and multidimensional cities. A vibrant coastal metropolis on the Mediterranean, Tel Aviv is the cultural, financial, and technological center of Israel.
Visit Tel Aviv
Learn under the guidance of a world-class faculty in the U.S. capital - the seat of the federal government; home to 177 embassies; headquarters of international policy-making bodies and think tanks; and the site of many museums, monuments and cultural institutions.
Visit Washington, D.C.
From leading international centers for research and education, to one of the most technologically advanced lecture halls and screening facilities in New York City, the varied institutes and centers at NYU serve as critical points of convergence for the University experience.


text:
Grand Rapids Theological Seminary
Why GRTS?
CU Stance on Justice
Give to GRTS
Why Seminary?
History & Values
Visit GRTS
Seminary Degree Programs
HyFlex Course Delivery
Academic Catalog and Calendar
Israel, Palestine and Jordan Study Tour
Pirsig Fellowship
Urban Cohort
Special Programs & Certifications
Hoch Bookroom
Thursday Evening Bible Class
Intercultural Studies Lecture Series
Christian Worldview Center
Ministry Leaders Program
All Programs Faculty Directory
Learn more about GRTS.
Thank you for your interest in learning more about Grand Rapids Theological Seminary! For more information, please contact the Admissions team.
Seminary Overview
Denomination: Multi-Denominational
Faculty: 10:1 Student-to-Faculty Ratio
Enrollment: 337 Students (Spring 2018)
Gender: 52% Female; 48% Male
Cost: $550 Per Credit Hour (2018-19 Year)
Financial Aid: 77% of Students Receive Financial Aid
Master of Arts in Biblical Exegesis
Master of Arts in Christian Formation
Master of Arts in Christian Studies
Master of Theology (Th.M.)
Degrees Preparation
Q: Can I specialize my degree to my area of interest?
A: Yes! All of our programs have elective space that allow you to tailor your degree. Several of our programs include specializations that allow you to graduate with an area of emphasis on your degree. For example, Master of Divinity students can specialize in Pastoral Ministries, Student and Family Ministries, Small Group ad Discipleship Ministries, Intercultural Ministries, Formation and Soul Care Ministries, Chaplaincy, and Academic. We also offer specializations within the M.A. Biblical Exegesis, M.A. Counseling and M.A. Christian Formation degrees. Please see the individual degree pages to learn more.
Q: Does the MA Counseling program prepare me for state licensure?
A: Yes, the M.A. Counseling degree at GRTS is approved by the State of Michigan to provide training towards LPC status. For more details see the M.A. Counseling page.
Theological Distinctions
Q: What sets GRTS apart from other seminaries?
A: Each seminary will have particular strengths. The primary mission of GRTS is to educate students who are gifted for ministry for service in the church and other ministry settings. As a multi-denominational school GRTS trains students from many different backgrounds and this is reflected in the curriculum and classroom discussion. GRTS is also committed to engaging education from a high view of Scripture and to exegeting the Bible in its original languages. The Ministry Residency program at GRTS provides an in-depth ministry training experience for ministry students. M.A. Counseling students complete Practicum and Internships as part of their practical training prior to graduation. GRTS also integrates academic learning and classroom discussion with practical hands-on training.
Q: I have a diverse denominational background. Will I fit in?
A: Yes, students at GRTS come from many different church backgrounds and denominations. GRTS values learning together in community and students find that they have others who can identify with them and encourage them during their time at seminary.
Q: Will my denomination accept my degree from GRTS?
A: Most denominations will accept a degree from GRTS as part of the requirements for ordination. However, it is important to verify with the denomination (or church association) in which you plan to serve to confirm that they do recognize GRTS degrees. Each denomination establishes their own ordination process and standards so it is advisable to be in contact with your church to confirm their requirements.
81% of Graduates are Employed in Various Forms of Vocational Ministry
83% of Students Graduate within 5 Years
66% of Students who Begin a Degree Program, Complete a Degree Program
87% of Students Achieved the Highest Outcome ("Making Good Progress in Readiness for Ministry") in the Midpoint Assessment
97% of Students Achieved the Highest Outcome ("Making Good Progress in Readiness for Ministry") in the Exit Assessment
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My Cornerstone
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Cornerstone University does not discriminate on the basis of race, national origin, sex, age, disability or veteran status in any of its education policies and programs that it operates.


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text:
Harpenden child with cancer fundraising for experimental treatment in New York
Franki Berry
Published: 7:00 PM January 3, 2018
Isla Austin. Picture: Rick Austin - Credit: Archant
The parents of a toddler with a rare form of cancer are desperately fundraising to obtain an experimental vaccine which offers her best chance at survival.
Two-year-old Isla Austin, who lives in Leverstock Green, was found to have stage IV high-risk neuroblastoma in late 2016 after a growth on her cheek was initially misdiagnosed as mumps.
When neither of her two siblings contracted the infectious illness, her parents Rick and Anna started to suspect something was wrong. On her first birthday, doctors in St Albans told them Isla actually had cancer.
The tumour on her face was just the tip of the iceberg, with a primary 9cm tumour on her kidney and two more secondary growths in her legs and ribs.
Isla started treatment almost immediately and has since undergone seven and a half hours of surgery, radiotherapy, and intense chemotherapy four times a day.
Doctors at Great Ormond Street Hospital had to extract 10,000,000 stem cells from Isla by blood transfusion to protect them from the blasts of radiation designed to kill the terminal lumps.
Rick said: "We felt numb, one moment you are preparing for her birthday and the next moment you are being told she has cancer.
"We just couldn't believe it was happening. You are numb with shock. Your life is turned around.
"These treatments aren't kind on such a little child, but she has made many amazing recoveries. Her determination shines through the smile on her face. She is simply an inspiration to everyone privileged to know her."
Isla finished her treatment program on Christmas Eve and although she is currently clear of cancer, the relapse rate for the rare illness is very high.
If it comes back, her survival rate is only ten per cent and for every reoccurrence the mortality rates become more bleak.
A pioneering new clinical trial at New York's Memorial Sloan Kettering Cancer Center aims to lower the chance of relapse for children like Isla and Rick and Anna hope to send her there to try it out.
Howver, the Bivalent Vaccine would cost £155,000 - an "overwhelming" amount for the family.
Rick said: "It would be fantastic if you could get her over there because it's awful thinking we have done all this and our daughter is still in high danger of relapse.
"It's such a large number to raise at first but as her parents we would do anything and there should be no barrier to get your child the best treatment."
They have already collected more than £45,000 but are pushing to reach their target before February.
Anna added: "Isla was home for Christmas but she was very unwell, underweight and had not long finished her chemotherapy. She had no hair and she had tubes in her nose. She looked like a child with cancer, unable to sit properly due to open wounds from a bone marrow aspiration on her lower back.
"Our hope this year is that she'll be running around opening presents like other children her age."
She added: "We are determined to give Isla the best chance, even if it gives her one extra day, then it would have been worth it."
Fundraising events planned include golf days, charity football matches, Tough Mudder runs, and raffles.
The whole family is getting involved, with Anna's cousin Dan running a marathon distance around GOSH - 52 circuits - and Rick's brother in law walking 155km from Kent to GOSH in London.
Rick and Anna described Isla as "lively, happy, playful and bubbly", and "like most girls her age, loves being creative and adores anything pink, sparkly and cuddly".
Isla has the support of charity Solving Kids' Cancer, which helps families affected by neuroblastoma to access better treatment.
To donate click here.


Sometimes you need to sit back enjoy the view. Reaping the rewards of your hard work. Days like this, I enjoy sipping on my refrigerator tea recipe.
Instead of traditional sun tea, I make refrigerator tea.
1.) Fill your container or pitcher with one quart of cold water.
2.) Place the 5 or 6 tea bags in the water and place in refrigerator overnight.
3.) In the morning remove the tea bags. Squeeze out the moisture.
Easy enough isn't it? You can purchase any flavor tea you would like to try. I personally like black teas with lemon or orange flavorings.


text:
Marcus Schwarzrock (* 4. März 1967 in Hamburg) ist aktuell Bundestrainer für die U23 Athleten des Deutschen Ruderverbandes und ehemaliger Ruderer aus Hamburg.

Sein beruflicher Werdegang hat ihn über verschiedene Stationen als Vereinstrainer und Mitglied der deutschen Nationalmannschaft sowie als Trainer von Olympischen und nicht-Olympischen Bootsgattungen bis zum festangestellten Trainer geführt. Er war sportlicher Leiter beim Ruder-Club Allemannia von 1866 Hamburg und ab 2005 Bundestrainer Rudern/Skullen der B-Senioren. Schwarzrock hat seit den frühen 90er Jahren deutsche Mannschaften auf Weltmeisterschaften trainiert, meist mit Medaillenerfolg (u. a. WM Gold im Leichtgewichts-Achter 2003, Silber 2002). Bei den  Olympischen Spielen 2012 gewann der von ihm trainierte Männer-Doppelvierer die Goldmedaille.

Im Dezember 2012 wurde er als Nachfolger von Hartmut Buschbacher zum Cheftrainer des Deutschen Ruderverbandes ernannt. Ab  2017 verantwortete er als Disziplintrainer den Männer Skullbereich (A-Senioren). Seit November 2021 ist er als Bundestrainer im Nachwuchsbereich für die U23 Athleten zuständig. Bei der U23-WM im Juli 2022 in Varese / Italien führte er das Team bei 20 Starts und 16 erreichten A-Final-Teilnahmen zu 10 Medaillen, davon 7 in den olympischen Bootsklassen.

Weblinks

 Ruderclub Allemannia

Einzelnachweise

Rudertrainer
Nationaltrainer (Deutschland)
Deutscher
Geboren 1967
Mann

redpajama_set_name: RedPajamaWikipedia


text:
Q: DATA NOT INSERT, cause of near table syntax error After i click on "AddData" button, then the app show "DATA NOT INSERT".
How to fix this problem?
Who knows where to get a good tutorial for learning SQLite?
E/SQLiteLog: (1) near "table": syntax error
     E/SQLiteDatabase: Error inserting NAME=hi MARKS=98 SURNAME=ju
     android.database.sqlite.SQLiteException: near "table": syntax error (code 1): , while compiling: INSERT INTO student.table(NAME,MARKS,SURNAME) VALUES (?,?,?)
    at android.database.sqlite.SQLiteConnection.nativePrepareStatement(Native Method)
    at android.database.sqlite.SQLiteConnection.acquirePreparedStatement(SQLiteConnection.java:887)
    at android.database.sqlite.SQLiteConnection.prepare(SQLiteConnection.java:498)
    at android.database.sqlite.SQLiteSession.prepare(SQLiteSession.java:588)
    at android.database.sqlite.SQLiteProgram.<init>(SQLiteProgram.java:58)
    at android.database.sqlite.SQLiteStatement.<init>(SQLiteStatement.java:31)
    at android.database.sqlite.SQLiteDatabase.insertWithOnConflict(SQLiteDatabase.java:1469)
    at android.database.sqlite.SQLiteDatabase.insert(SQLiteDatabase.java:1341)
    at com.example.user.sqliteapp2.DatabaseHelper.insertData(DatabaseHelper.java:42)
    at com.example.user.sqliteapp2.MainActivity$1.onClick(MainActivity.java:32)
    at android.view.View.performClick(View.java:5198)
    at android.view.View$PerformClick.run(View.java:21147)
    at android.os.Handler.handleCallback(Handler.java:739)
    at android.os.Handler.dispatchMessage(Handler.java:95)
    at android.os.Looper.loop(Looper.java:148)
    at android.app.ActivityThread.main(ActivityThread.java:5417)
    at java.lang.reflect.Method.invoke(Native Method)
    at com.android.internal.os.ZygoteInit$MethodAndArgsCaller.run(ZygoteInit.java:726)
    at com.android.internal.os.ZygoteInit.main(ZygoteInit.java:616)
    V/RenderScript: 0x7f27c755c000 Launching thread(s), CPUs 2
    E/Surface: getSlotFromBufferLocked: unknown buffer: 0x7f27cf39e610

This is my code.
public class DatabaseHelper extends SQLiteOpenHelper {
public static final String DATABASE_NAME ="student.db";
public static final String TABLE_NAME ="student.table";
public static final String COL_1="ID";
public static final String COL_2="NAME";
public static final String COL_3="SURNAME";
public static final String COL_4="MARKS";
public DatabaseHelper(Context context){
    super(context,DATABASE_NAME,null,1);

}

@Override
public void onCreate(SQLiteDatabase db) {

    db.execSQL("Create Table " + TABLE_NAME + "(ID INTEGER PRIMARY KEY AUTOINCREMENT, NAME TEXT, SURNAME TEXT, MARKS TEXT);");

}

@Override
public void onUpgrade(SQLiteDatabase db, int oldVersion, int newVersion) {
    db.execSQL("DROP TABLE IF EXIST"+TABLE_NAME);
    onCreate(db);
}
public boolean insertData(String name,String surname,String marks){
    SQLiteDatabase db=this.getWritableDatabase();
    ContentValues contentValues=new ContentValues();
    contentValues.put(COL_2,name);
    contentValues.put(COL_3,surname);
    contentValues.put(COL_4,marks);
    long result=db.insert(TABLE_NAME,null,contentValues);
    if(result==-1)
        return false;
    else
        return true;
}
    }

Can anybody help me?

A: use this line to create the table :-
 db.execSQL("CREATE TABLE " + TABLE_NAME + "("
                + COL_1+ " INTEGER," + COL_2 + " TEXT," + COL_3+ " TEXT," + COL_4 + " TEXT" + ")";);

and please be careful to write the code. because wrong syntax does produce the error. so please write the code same as it is i wrote.

redpajama_set_name: RedPajamaStackExchange


Evicted from their protest camp outside Manchester's town hall, homeless residents have dug in their heels from street to street. They are facing off with a city government that slashed homeless funding by £2million (US$3 million) this year despite a six-fold increase in the number of people sleeping rough since 2010.
Across England that number has increased 55 per cent since Conservative Prime Minister David Cameron was first elected that year. The latest official figures also show the number of households in temporary accommodation has reached 65,000 – the highest figure since the financial crisis of 2008.
Jen Wu, an artist and activist has been spending time with the camp for six weeks and has chronicled her experiences on her website. "The first night I came down and just crashed in the tent and chatted with people until around eight in the morning," she says.
The camp has acquired national recognition as a symbol for the plight of homeless people in the UK, winning support from activists around the country, their Facebook page boasting over 3,000 likes. Trade union representatives of UNISON – Britain's largest trade union - visited the camp and made a donation.
Britain is facing a homeless crisis on an unprecedented scale, with leading charities warning that the situation is likely to deteriorate over the next few years unless the government takes drastic steps to avoid disaster.
While several factors have been blamed for the rise, a report released earlier this year by Crisis revealed that three-quarters of all homeless acceptances between 2010 and 2014 were attributable to evictions from the private rented sector.
Yet while the cost of rent becomes increasingly unaffordable for millions of people the Conservative government promised to cut billions of pounds in public spending over the next five years.
Charities fear this together with the failure to invest in social housing will only exacerbate the problem.
"The biggest cause is a lack of supply of housing, both in general terms in that there isn't enough housing overall but also there is a lack of affordable housing," says Francesca Albanese, a research manager at Homeless Link, a London-based organisation.
London has arguably been affected worse than anywhere else in the UK with the number of people sleeping rough increasing by 37 per centbetween 2013 and 2014, compared to 7 per cent nationally.
The government's own report into the causes of homelessness paints a disturbing picture. Previously the majority of homeless cases were recorded as being the result of 'behavioural' factors, such as relationship breakups. However, figures suggest the primary causes of homelessness may be the result of structural factors.
The single biggest recorded reason for homelessness is now the loss of an assured short-term tenancy - the type of tenancy most commonly held by private renters – which guarantees the tenant the right to have their deposit protected and be given notice of eviction.
This suggests an increasing proportion of those living on the streets were made homeless due to factors outside of their control. Meanwhile, as homeless figures continue to rise, homelessness provisions are being cut by Manchester and other local authorities across the country as they struggle to cope with austerity imposed on them by central government.
In response, many of those living on the streets have taken matters into their own hands, organising political demonstrations and demanding that councils provide them with permanent housing. In April, following an anti-austerity demonstration, a group of homeless protestors formed an Occupy style camp in one of the Manchester's main squares outside the town hall.
Following a legal battle with the council, the protestors were evicted from their initial spot and subsequently moved to a nearby public street, yet the council has renewed attempts to have them evicted.
Their demands are simple. "They want all the camp residents to be offered permanent accommodation, not temporary hostel accommodation and they want a review of Manchester City Council's homeless policy," says Ben Taylor, a solicitor representing the protestors.
The homeless policy refers to the council's categorisation of homeless people into two camps: those who are unintentionally homeless and those who have chosen to live on the streets. Under the under the Housing Act 1996, local councils are obliged to provide accommodation to those who are unintentionally homeless. The issue, according to Taylor, is that councils may classify someone as intentionally homeless when a proper assessment of their circumstances would reveal otherwise.
"An example would be if you've been evicted because of rent arrears, because of the bedroom tax, he explains, "As we know the bedroom tax was a creation of the last government whereby housing benefits would not be paid for the whole of your rent if you had a spare room on the basis that you get someone in to live with you or you should downsize.
Earlier this year Homeless Link launched a manifesto in which it identified five key areas in which government policy must change in order to meet the social challenges presented by the homelessness crisis.
Among them: stronger rights for tenants, better support for job placement, an effective welfare safety net, and a commitment to end rough sleeping. All of which cost money.
I really hope that somone does something about it soon before it gets out of hands. Homeless people are humans too and they should not be treated in a bad way.


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This is the forty-second of 87 letters exchanged during World War II between Nicholas Salvatore and Elizabeth Galloway. For more see Nicholas and Elizabeth.
I am covered with red crosses and as per the Geneva convention am to be treated as a noncombatant. Sometimes, however, it feels more like a target. If the Germans talk like some of our own men do, then they have little respect for me. As I often hear from our side, the only good Nazi is a dead Nazi. I figure that must go both ways. What is my enemy? Death. My weapons are morphine and a hope the kid still believes in god. I am obliged to help the wounded – ally and enemy alike. The blood is the same, the pain is the same. When you are trying to stop a chest wound that is gushing blood it's impossible to tell if it's a Nazi, an American or Jesus Christ himself. I tell them whatever they want to hear when they're dying. I tell them everything is going to be alright. I don't think it's a lie. Wherever they're going has to be better than this nightmare. Some cry, some rage against it. Sometimes I dictate last words to loved ones that I will never send. I hold their hands and shoulders and feel their bodies go limp. My training failed me and them by teaching me only how to treat the body.
Instead of trying to block out the sounds of war and the marching of death I now focus all of my attention on it until the gunfire and screams of men turn into shapes and colors. I am lost in the white noise.


text:
Lost Heaven Multiplayer
How to get it work
How to improve this webpage
Welcome to the official website of Lost Heaven Multiplayer.
"Mr. Salieri sends his regards." - Vito Scaletta
Lost Heaven Multiplayer (LHMP) was a fan-made modification of legendary video game Mafia:The City of Lost Heaven, produced by Illusion Software (today 2K Czech) and released in 2002. The aim of modification was to enhance the original game with multiplayer experience, similar to other popular multiplayer modifications such as SA-MP.
The project initialy started in August 2013 as a hobby attempt of 3 young boys from Slovakia and ended in Summer 2015. The reason was a lack of time due. As for today, project is no longer officially supported, and neither technical, nor mentor support is provided by the original team.
This page has been set up in order to preserve our story and to provide a guide to eager Mafia players that would like to at least try it on their own.
The project was programmed in C++ with chunks of inline Assembler. Due to lack of software engineering skills and experience (that time we were 18-, 16- and 15-years old), the created code resulted in a messy composition of classes connected using a single Singleton. Therefore, there is no ambition to continue the currect project with completely rewriting it from the scratch.
The project files can be found in our official GitHub repo. The compilation process requires some skills with using Make, Visual Studio and C++.
No official binary archives are provided, yet. However, this may change once when someone dares to leave the comfort zone.
Below we mention the names of original 3 authors.
Roman Dobias (Romop5)
Dominik Madarasz (Zaklaus)
David Svitana (Davo)
Credits also go to all guys who helped us with testing, to Qbt from Finland, who created a Qt-based server browser and improved quality of project in its final days.
Mafiascene.com
Here you can find some preserved memories from those glory days.
In case you were a part of our community and you would feel that there was something that should appear here, fork us at GitHub and it may happen.


text:
By Shawn Donnelly / November 24, 2016
The 12 Most Entertaining Holiday Films of All Time
Die Hard (Getty Images)
Eyes Wide Shut (Getty Images)
Chances are, in the next month you're going to be with a group of people who want to watch a holiday movie. But that doesn't mean you have to queue up Miracle on 34th Street. (Or worse, The Santa Clause.)
Instead, you should settle in by the fire with one of these—our picks for the 12 most entertaining holiday films of all time. Sure, they have a Yuletide vibe (some stronger than others). But they've also got something that's missing from the likes of Jingle All the Way: attitude.
Bad Santa (Columbia Pictures)
12. Bad Santa (2003)
Watching Billy Bob Thornton swill booze and yell at kids while wearing a Santa costume somehow never gets old. It's also a pleasure to watch both John Ritter and Bernie Mac, two fine actors who are sadly no longer with us.
11. Trading Places (1983)
An '80s take on Mark Twain's The Prince and the Pauper, Trading Places showcases Eddie Murphy and Dan Aykroyd at the height of their comedic powers. Interestingly, in Italy the movie has become a Christmas classic; it's broadcast every year, usually on December 24.
10. Pieces of April (2003)
Shot for a mere $100,000, Pieces features a twenty-something, pre-Tom Cruise Katie Holmes trying to make Thanksgiving dinner for her family in a tiny New York City apartment without a working oven. Sound boring? The New York Times disagreed, calling it "an intelligent and touching farce."
Elf (New Line Cinema)
9. Scrooged (1988)
Your enjoyment of this film (an update of Charles Dickens' A Christmas Carol) greatly depends on how much you enjoy Bill Murray. If you (like most logical human beings) are a fan, then, to borrow a line from the film, "Yule love it!"
8. Elf (2003)
Nobody plays an orphan who thinks he's one of Santa's elves better than Will Ferrell, and Elf, while not exactly packing "attitude," offers plenty of laughs to go with its Christmas cheer and family-ness. Also, Peter Dinklage as a best-selling children's author is priceless.
7. A Very Harold & Kumar 3D Christmas (2011)
This is easily the best three-dimensional stoner comedy Christmas movie in the history of cinema. And while it's all pretty silly, there are some important themes here. Namely: reconnecting with old friends and standing up to in-laws.
The Apartment (Getty Images)
6. National Lampoon's Christmas Vacation (1989)
This is arguably Chevy Chase's last movie before he got unfunny, and Randy Quaid is a tour de force as the turtleneck dickey-wearing Eddie. Look closely to spot a pre-Big Bang Theory Johnny Galecki and a pre-Seinfeld Julia Louis-Dreyfus.
5. Gremlins (1984)
Talk about a misunderstood picture. It's known as a Spielberg movie, although he served as executive producer, not director. (It was directed by Joe Dante and written by future Home Alone helmer Chris Columbus.) It's also thought to be a kid's film, but it's loaded with black comedy elements.
Gremlins are blown up in a microwave and a movie theater, and the main character's girlfriend (Phoebe Cates) hates Christmas because her father died in a chimney while dressed as Santa Claus. Dark stuff indeed. No wonder the MPAA created the PG-13 rating as a reaction to this film.
This is probably the best buddy cop film ever, but it's also very much a holiday movie. There's a chase down Hollywood Boulevard on Christmas Eve, a shootout at a Christmas tree farm, and it ends (spoiler alert) with Riggs spending Christmas with Murtaugh and his family. Plus, the whole thing starts with "Jingle Bell Rock."
3. The Apartment (1960)
First of all, without this Billy Wilder film, there would be no Mad Men. Also, it's got the greatest holiday office party scene in cinematic history. Then there's the supremely charming Jack Lemmon, everyman-ing it up opposite Shirley MacLaine (at her most adorable). Fred MacMurray as the dirtbag boss is the icing on it, cake-wise.
2. Eyes Wide Shut (1999)
Stanley Kubrick's last movie, Eyes Wide Shut holds the Guinness World Record for the longest continuous film shoot period (more than 15 months). The novella on which it was based, Dream Story, was set during Mardi Gras (in Vienna), but Kubrick changed it to Christmas (in New York). The switch works perfectly.
Alonso Duralde, in his book Have Yourself a Movie Little Christmas, calls the erotic drama a "Christmas movie for grownups." And critic Lee Siegel suggests that the film's recurring motif is the Christmas tree, writing, "Desire is like Christmas: It always promises more than it delivers."
1. Die Hard (1988)
Made for $28 million, Die Hard grossed more than $140 million theatrically, turned Bruce Willis into an action star, spawned four sequels, and is considered one of the best action movies ever made, as well as one of the greatest films ever made.
But people don't really think of it as a holiday movie. Well, they should. The entire story takes place on Christmas Eve, and Hans Gruber and his henchmen seize the Nakatomi Tower during the company Christmas party.
What's more, the score features sleigh bells and "Winter Wonderland," and the end credits begin with "Let It Snow." Yippee-ki-yay? Sure. But also: Ho-ho-ho!
—Shawn Donnelly for RealClearLife


text:
Systematic review and meta-analysis of biosimilar for the treatment of rheumatoid arthritis informing the 2020 update of the Japan College of Rheumatology clinical practice guidelines for the management of rheumatoid arthritis
Eiichi Tanaka, Yutaka Kawahito, Masataka Kohno, Shintaro Hirata, Mitsumasa Kishimoto, Yuko Kaneko, Hiroya Tamai, Yohei Seto, Akio Morinobu, Takahiko Sugihara, Atsuko Murashima, Masayo Kojima, Masaaki Mori, Hiromu Ito, Toshihisa Kojima, Yasumori Sobue, Keiichiro Nishida, Isao Matsushita, Takeo Nakayama, Hisashi YamanakaMasayoshi Harigai
Department of Internal Medicine (Rheumatology)
Objectives: To evaluate the efficacy and safety of biosimilars compared with reference biological disease modifying antirheumatic drugs (bDMARDs) in patients with rheumatoid arthritis (RA) as a part of the process of developing the 2020 update of the Japan College of Rheumatology guidelines for the management of RA. Methods: PubMed, Cochrane Library, and Japan Centra Revuo Medicina were searched for articles to conduct a systematic review (SR). The quality of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation system. Results: Twenty randomized controlled trials were included (biosimilars of infliximab, etanercept, and adalimumab). A meta-analysis revealed that the risk ratios (RRs) and 95% confidence intervals (CIs) of achieving the American College of Rheumatology 50% response (ACR50) at week 24 and serious adverse events (SAEs) for biosimilars compared with the reference bDMARDs were 1.04 (0.98–1.10) and 0.84 (0.61–1.18), respectively. The RRs of achieving ACR50 and SAEs at week 24 were respectively 0.93 (0.69–1.26) and 2.15 (0.55–8.35) in the patients who switched to biosimilars from the reference bDMARDs and 0.92 (0.76–1.12) and 1.41 (0.32–6.15) in those who continued the reference bDMARDs. Conclusion: Biosimilars and reference bDMARDs were equally useful for the management of RA.
Modern rheumatology
Biological disease modifying antirheumatic drug
GRADE system
Dive into the research topics of 'Systematic review and meta-analysis of biosimilar for the treatment of rheumatoid arthritis informing the 2020 update of the Japan College of Rheumatology clinical practice guidelines for the management of rheumatoid arthritis'. Together they form a unique fingerprint.
Biosimilar Pharmaceuticals Medicine & Life Sciences 100%
Antirheumatic Agents Medicine & Life Sciences 85%
Rheumatology Medicine & Life Sciences 77%
Practice Guidelines Medicine & Life Sciences 67%
Meta-Analysis Medicine & Life Sciences 53%
Tanaka, E., Kawahito, Y., Kohno, M., Hirata, S., Kishimoto, M., Kaneko, Y., Tamai, H., Seto, Y., Morinobu, A., Sugihara, T., Murashima, A., Kojima, M., Mori, M., Ito, H., Kojima, T., Sobue, Y., Nishida, K., Matsushita, I., Nakayama, T., ... Harigai, M. (Accepted/In press). Systematic review and meta-analysis of biosimilar for the treatment of rheumatoid arthritis informing the 2020 update of the Japan College of Rheumatology clinical practice guidelines for the management of rheumatoid arthritis. Modern rheumatology. https://doi.org/10.1080/14397595.2021.1899591
Systematic review and meta-analysis of biosimilar for the treatment of rheumatoid arthritis informing the 2020 update of the Japan College of Rheumatology clinical practice guidelines for the management of rheumatoid arthritis. / Tanaka, Eiichi; Kawahito, Yutaka; Kohno, Masataka et al.
In: Modern rheumatology, 2021.
Tanaka, E, Kawahito, Y, Kohno, M, Hirata, S, Kishimoto, M, Kaneko, Y, Tamai, H, Seto, Y, Morinobu, A, Sugihara, T, Murashima, A, Kojima, M, Mori, M, Ito, H, Kojima, T, Sobue, Y, Nishida, K, Matsushita, I, Nakayama, T, Yamanaka, H & Harigai, M 2021, 'Systematic review and meta-analysis of biosimilar for the treatment of rheumatoid arthritis informing the 2020 update of the Japan College of Rheumatology clinical practice guidelines for the management of rheumatoid arthritis', Modern rheumatology. https://doi.org/10.1080/14397595.2021.1899591
Tanaka E, Kawahito Y, Kohno M, Hirata S, Kishimoto M, Kaneko Y et al. Systematic review and meta-analysis of biosimilar for the treatment of rheumatoid arthritis informing the 2020 update of the Japan College of Rheumatology clinical practice guidelines for the management of rheumatoid arthritis. Modern rheumatology. 2021. doi: 10.1080/14397595.2021.1899591
Tanaka, Eiichi ; Kawahito, Yutaka ; Kohno, Masataka et al. / Systematic review and meta-analysis of biosimilar for the treatment of rheumatoid arthritis informing the 2020 update of the Japan College of Rheumatology clinical practice guidelines for the management of rheumatoid arthritis. In: Modern rheumatology. 2021.
@article{675f195145094458bd4691385d9b1e67,
title = "Systematic review and meta-analysis of biosimilar for the treatment of rheumatoid arthritis informing the 2020 update of the Japan College of Rheumatology clinical practice guidelines for the management of rheumatoid arthritis",
abstract = "Objectives: To evaluate the efficacy and safety of biosimilars compared with reference biological disease modifying antirheumatic drugs (bDMARDs) in patients with rheumatoid arthritis (RA) as a part of the process of developing the 2020 update of the Japan College of Rheumatology guidelines for the management of RA. Methods: PubMed, Cochrane Library, and Japan Centra Revuo Medicina were searched for articles to conduct a systematic review (SR). The quality of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation system. Results: Twenty randomized controlled trials were included (biosimilars of infliximab, etanercept, and adalimumab). A meta-analysis revealed that the risk ratios (RRs) and 95% confidence intervals (CIs) of achieving the American College of Rheumatology 50% response (ACR50) at week 24 and serious adverse events (SAEs) for biosimilars compared with the reference bDMARDs were 1.04 (0.98–1.10) and 0.84 (0.61–1.18), respectively. The RRs of achieving ACR50 and SAEs at week 24 were respectively 0.93 (0.69–1.26) and 2.15 (0.55–8.35) in the patients who switched to biosimilars from the reference bDMARDs and 0.92 (0.76–1.12) and 1.41 (0.32–6.15) in those who continued the reference bDMARDs. Conclusion: Biosimilars and reference bDMARDs were equally useful for the management of RA.",
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author = "Eiichi Tanaka and Yutaka Kawahito and Masataka Kohno and Shintaro Hirata and Mitsumasa Kishimoto and Yuko Kaneko and Hiroya Tamai and Yohei Seto and Akio Morinobu and Takahiko Sugihara and Atsuko Murashima and Masayo Kojima and Masaaki Mori and Hiromu Ito and Toshihisa Kojima and Yasumori Sobue and Keiichiro Nishida and Isao Matsushita and Takeo Nakayama and Hisashi Yamanaka and Masayoshi Harigai",
note = "Publisher Copyright: {\textcopyright} 2021 Japan College of Rheumatology.",
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AU - Seto, Yohei
AU - Morinobu, Akio
AU - Sugihara, Takahiko
AU - Murashima, Atsuko
AU - Kojima, Masayo
AU - Mori, Masaaki
AU - Ito, Hiromu
AU - Kojima, Toshihisa
AU - Sobue, Yasumori
AU - Nishida, Keiichiro
AU - Matsushita, Isao
AU - Nakayama, Takeo
AU - Yamanaka, Hisashi
AU - Harigai, Masayoshi
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N2 - Objectives: To evaluate the efficacy and safety of biosimilars compared with reference biological disease modifying antirheumatic drugs (bDMARDs) in patients with rheumatoid arthritis (RA) as a part of the process of developing the 2020 update of the Japan College of Rheumatology guidelines for the management of RA. Methods: PubMed, Cochrane Library, and Japan Centra Revuo Medicina were searched for articles to conduct a systematic review (SR). The quality of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation system. Results: Twenty randomized controlled trials were included (biosimilars of infliximab, etanercept, and adalimumab). A meta-analysis revealed that the risk ratios (RRs) and 95% confidence intervals (CIs) of achieving the American College of Rheumatology 50% response (ACR50) at week 24 and serious adverse events (SAEs) for biosimilars compared with the reference bDMARDs were 1.04 (0.98–1.10) and 0.84 (0.61–1.18), respectively. The RRs of achieving ACR50 and SAEs at week 24 were respectively 0.93 (0.69–1.26) and 2.15 (0.55–8.35) in the patients who switched to biosimilars from the reference bDMARDs and 0.92 (0.76–1.12) and 1.41 (0.32–6.15) in those who continued the reference bDMARDs. Conclusion: Biosimilars and reference bDMARDs were equally useful for the management of RA.
AB - Objectives: To evaluate the efficacy and safety of biosimilars compared with reference biological disease modifying antirheumatic drugs (bDMARDs) in patients with rheumatoid arthritis (RA) as a part of the process of developing the 2020 update of the Japan College of Rheumatology guidelines for the management of RA. Methods: PubMed, Cochrane Library, and Japan Centra Revuo Medicina were searched for articles to conduct a systematic review (SR). The quality of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation system. Results: Twenty randomized controlled trials were included (biosimilars of infliximab, etanercept, and adalimumab). A meta-analysis revealed that the risk ratios (RRs) and 95% confidence intervals (CIs) of achieving the American College of Rheumatology 50% response (ACR50) at week 24 and serious adverse events (SAEs) for biosimilars compared with the reference bDMARDs were 1.04 (0.98–1.10) and 0.84 (0.61–1.18), respectively. The RRs of achieving ACR50 and SAEs at week 24 were respectively 0.93 (0.69–1.26) and 2.15 (0.55–8.35) in the patients who switched to biosimilars from the reference bDMARDs and 0.92 (0.76–1.12) and 1.41 (0.32–6.15) in those who continued the reference bDMARDs. Conclusion: Biosimilars and reference bDMARDs were equally useful for the management of RA.
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