text:
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redpajama_set_name: RedPajamaGithub


ONDU is a line of wooden chestnut and maple pinhole cameras designed in Slovenia by Elvis Halilović.
The camera was funded via a Kickstart project. The project was launched in May 13, 2013. The goal was raised in less than 48 hours. At the end of the funding period (June 12, 2013) $109,391 was raised surpassing the original goal of $10,000.
This page was last edited on 7 April 2018, at 02:05.


Discover Best Windshield Wiper Glasses Of 2018. Buyer's Guide.
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Our team has been working on this list of the best windshield wiper glasses for many days. We had to compare many models from various brands. In the end, we selected 10 windshield wiper glasses with the highest price/quality ratios.
No chemicals & clean with water — includes 2 removable washable microfiber covers.
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2) more conveniently and easily to use than traditional windscreen cleaner.
Great for car windows and more — works great as a fog & moisture removal tool. Use the cleaning brush set in your car, hard to reach windows in your house, television, glass screens, glass mirrors and even floors. Easy using — simply slip one of the microfiber bonnets on the head, spray with water, and start washing. No chemicals & clean with water — includes 2 removable washable microfiber covers. No need for throw away wipes and pads. The covers remove more dirt, dust and tar; cleans using plain tap water. Just throw them in the washing machine to clean. Makes cleaning windshield fast and easy — clean car window interiors and exteriors without straining. With the extra long 16″ extension handle and pivoting head getting to those hard-to-reach car window bases is simple. You get the cleaner and clearer shine every time.
Is Amazone.com a good place to buy a windshield wiper glasses?
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Keep car shiny: the tools are specially designed for easy use, convenient for you to hold and clean your car thoroughly, for car surface, leather car seat, windshield, hood, doors, windows and ect. Keeping your car, truck, auto, van and motorcycle clean and shiny all the time. The spray bottle and 30.30cm microfiber cloth bring more useful situation for your car and house use. All of the kit can be stored in a bag which makes it easy to storage in your car when you don t use.
No measuring; no spills; no mess or plastic bottles to dispose of and no storage. Dissolve thoroughly; no residual and apply for all kinds of cars. Mixable with anti-freezing agent; for improved cleaning performance in winter. 2) more conveniently and easily to use than traditional windscreen cleaner. Turns regular water into powerful cleaning fluid; 6pcs solid glass cleaner equal 24l car glass water.
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How to get a refund for a windshield wiper glasses?
Shop has a customer-friendly return policy, which means that you will not have any difficulties returning your money. If there is something wrong with your windshield wiper glasses, you only need to contact the customer support and ask for a refund. However, you should carefully read the item's description before buying a windshield wiper glasses.
What warranty period is considered optimal for windshield wiper glasses?
We think that a two-year warranty is more than enough for a decent windshield wiper glasses. There are many premium options with a lifetime warranty, but we do not think that it is necessary. We recommend you to simply replace windshield wiper glasses with a new one after some time.
How did you create this rating list with the best windshield wiper glasses?
During the creation of this buying guide, we had to look through hundreds of windshield wiper glasses. Our team compared many products from various brands in order to find the most optimal model with the best price to quality ratio. The goal was to determine windshield wiper glassesthat offer the most value for their money, and we think that we have achieved it.


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Advocacy in Nursing: Resources for Nurse Practitioners
Academic Programs » Resources » Advocacy in Nursing: Resources for Nurse Practitioners
As frontline, patient-facing health care professionals, nurses play a vital role in advocating for patients. Advocacy can range from guiding patients in navigating a complex health care system and translating medical terms to helping them make informed decisions about their health. Nurses also can push for policies inside health care settings that improve patient outcomes.
Advocacy in nursing also can involve promoting ideas and policies that benefit colleagues and the nursing profession. For example, a nurse can advocate for a safe, healthy work environment for health care professionals in hospitals.
Nursing advocacy isn't limited to hospitals. Nurses willing to work directly with policymakers at the local, state, and federal levels can take political action for their communities. They can support initiatives to reduce health inequities, malnutrition, and domestic violence.
This guide highlights the importance of nurses supporting their patients and fellow nurses and standing up for professional nursing standards.
What Is Advocacy Work in Nursing?
Advocating for patient health is inherent in nursing roles. In essence, all nurses are patient advocates. Nursing: Scope and Standards of Practice, Fourth Edition describes the new advocacy standard — of individuals, families, groups, and communities —as a measure of performance in nursing. The American Nurses Association (ANA) describes Nursing: Scope and Standards of Practice, Fourth Edition, as a guide that provides "authoritative statements of the actions and behaviors that all registered nurses are expected to competently perform, regardless of role, population, specialty, and setting."
An example highlighting the importance of patient advocacy includes a patient case of passive acceptance. None of the nurses providing care acted on abnormal but mild signs of a health anomaly with a patient that was present over many shifts. This describes a case of passive acceptance. A nurse could have advocated for the patient to begin an investigation into the cause of the anomaly to provide better care for the patient.
In defining what advocacy in nursing is and explaining who benefits from it, it is important to highlight three components of nursing advocacy:
Nurse Advocacy for Patients
Nurse advocacy for patients can be informal, but some individuals serve in formal nurse advocacy roles. Nurses serving in these distinct positions have the clinical background of a typical nurse. Still, their primary focus is on defending patients' rights, ensuring that patients receive high-quality care, serving as liaisons between patients and physicians, listening to patients' concerns and grievances, connecting patients with resources, and helping patients and families deal with insurance companies.
Nurse Advocacy for the Nursing Profession
In health care organizations, employees can complete surveys to share important information about workplace improvements. Organizational leaders and human resources departments largely drive these employee surveys, rather than nurses working at patients' bedsides. Nurse advocates can employ other strategies, such as forums or town halls, to focus more on the issues that nurses face daily, both inside and outside hospitals. These issues can include safe and fair working conditions, adequate pay and compensation, and inclusion in policy and practice decision-making.
Nurse Advocacy for the Community
Some nurse advocates represent voices in their communities. They focus on ensuring the well-being of their communities by promoting an equitable, well-functioning health care infrastructure. Nurse advocates can use their expertise to inform and educate people about wellness and lend a hand in building a healthy, robust community.
The following links provide examples of advocacy work in the nursing field:
10 Nurse Advocacies and Campaigns You Need to Know, Nurselabs: Highlights of nurse advocacy groups and campaigns.
Nursing Advocacy Beyond the Bedside, Wolters Kluwer: Examples for nurses about advocating for patients, the profession, and themselves.
Patient Advocacy: 5 Ways to Advocate for Your Patients, Onward Healthcare: Strategies for nurses to promote advocacy.
Registered Nurses' Description of Patient Advocacy in the Clinical Setting, Wiley Online Library: An investigation of patient advocacy and its positive impact on delivering quality patient care.
How Does Advocacy in Nursing Benefit Patients?
Every nurse must adhere to ANA's Code of Ethics for Nurses, which highlights the importance of respecting, honoring, protecting, and providing safe environments for patients. The ability to mediate, educate, and communicate with patients is critical for nurses. All of these elements are foundational to nurse advocacy, which provides a myriad of benefits to patients.
How does advocacy in nursing benefit patients? Nurses can use the following strategies to help advocate for patients:
Treating patients with respect. When communicating with patients, it is important to have an open dialogue. By respecting them, including and not talking down to them, nurses help build trust.
Honoring patients' wishes. It is a nurse's job to help patients get better. However, nurses must also abide by a patient's wish regarding health care choices.
Protecting patients' rights. As an ethical principle, patients have a right to fair treatment. Nurses help ensure that their patients receive equal care and fair treatment, regardless of race, ethnicity, gender, language, religion, etc.
Keeping patients safe. Nurses ensure that patients receive the right doses of doctor-prescribed medicines and that room environments are secure.
Mediating conversations between patients and physicians. Patients may not have a clear understanding of what physicians are saying. Physicians also sometimes need help understanding patient concerns, due to time factors, language/cultural barriers, or other circumstances. Nurses serve as the go-betweens to ensure clinical accuracy and help address patient needs.
Educating patients about disease treatment and prevention, and healthy lifestyles. With their clinical knowledge and experience treating patients with all types of conditions, nurses can help patients understand the importance of choosing healthy habits for better health, including taking medicine as directed and having a healthy diet.
Communicating with patients' families and the health care team. A nurse should understand the concerns of both patients and their families and relay those concerns to members of the patients' health care team. In interdisciplinary health care settings, it also is important to coordinate care with team members, which helps reduce patient stress and lead to better outcomes.
Advocating for health policy changes. Nurses are the health care practitioners who patients interact with most, and as such, they can understand what patients need and deserve. This may mean challenging higher authorities to implement policies that help patients.
Nurses tend to advocate for patients before themselves. However, nurses should find opportunities to advocate for themselves by participating in nursing mentorships, which can help them acquire critical skills.
Nurses are ideal spokespeople for their field. They can advocate for the nursing profession by joining committees that influence policy and practice and by becoming active in professional nursing associations, such as the American Hospital Association, which has published its 2021 AHA Advocacy Agenda. The American Nurses Association (ANA) is another example of a nursing association that nurses can join.
The following resources include research, data, examples, and other information about how nursing advocacy benefits patients and why it's important in health care:
Patient Advocacy in Nursing: A Concept Analysis, SAGE Journals: A research-based analysis of patient advocacy in nursing.
The New Nurse Advocacy Standard: What Nurses Need to Know, American Mobile: What does ANA's new Nursing: Scope and Standards of Practice, Fourth Edition, mean for nurse advocacy. Learn more about the new standard in this resource.
Nurse Advocacy: Adopting a Health in All Policies Approach, American Nurses Association: A discussion of the benefits of nurse advocacy for achieving health equity, particularly in relation to poor and disadvantaged populations.
Nursing Advocacy, National Center for Biotechnology Information: A highlight of the importance of nursing self-advocacy and an investigation of the ways to promote it.
What Roles Do Nurse Lobbyists Play in Advocating for the Profession?
Professional lobbyists do various policy-related tasks, such as meeting with members of Congress or helping draft legislation. They receive payments from special interest groups, corporate clients, or others. Lobbyists must register with the federal government to do their job.
In the nursing field are a group of professionals known as nurse lobbyists, or health policy Analysts/lobbyists. These professionals promote advocacy in nursing on a large scale by combining their knowledge of health, health care, and the nursing profession with their policymaking, legislative, and communication skills to influence decisions from officials and lawmakers in local, state, and federal governments.
Nursing associations and other health care organizations employ lobbyists who communicate professional concerns, provide relevant data, and represent community concerns to lawmakers. Such policy advocacy helps shape health care legislation. Political and social issues that nurse lobbyists advocate for include:
The nursing shortage. Nurse lobbyists can help legislators understand the nursing shortage, including its implications on the health outcomes of patients.
Ensuring adequate nurse staffing. For all nurses to deliver safe, quality care, the health care setting must have proper nursing staff.
Inequities in the provision of health care. Nurses are mindful of how health inequity affects groups — ethnic minorities, immigrants, and low-income individuals, for example — from receiving the care they deserve. Legislators need help to understand how it impacts nurses and the general population.
Prevention of gun violence. Guns can have detrimental health effects on people. In the case of domestic violence or youth violence, the effects can spill over into health care settings, affecting nurses and patient outcomes.
Health care workplace health and safety. Nurses can face insults or even violence from uncooperative patients and their families. To ensure health outcomes for every patient, nurses must feel safe in their work setting.
Environmental health. Patients with all types of infectious diseases receive hospital care. Improving health care settings through building upgrades and modernization can help create healthier environments.
The following resources highlight how nurse lobbyists can affect legislation and policy by promoting the nursing profession and the patients' rights to quality health care:
Nurses as Self-Styled Lobbyists and Advocates, Ausmed: Explanation of nurse lobbying or advocacy and steps that nurses can take.
Nurses: How to Advocate for Federal Policy Change, Campaign for Action: Advice for nurses and professional nursing organizations interested in expanding their efforts.
Policy & Advocacy News, American Academy of Nursing: Examples of how the American Academy of Nursing serves the public and the nursing profession through nursing advocacy.
Federal Issues, American Nurses Association: A summary of how ANA advances the nursing profession and improves health and health care through advocacy.
Advocacy as the First Line of Defense for Nurses and Their Patients
Through their clinical and nursing training, nurses can help improve outcomes at patients' bedsides. The nursing profession has an increasing need for effective advocacy. Advocacy in nursing represents the interests of patients and promotes their health. After all, nurses have a professional and ethical duty to care for the patients in their care.
Nurse advocacy is also about letting decision-makers know what nurses need to succeed in their roles and about helping communities prosper. By joining nursing associations and participating in advocacy activities, nurses have a positive impact on the lives of patients. They can also serve families, peers, and communities in a greater capacity.
Online Graduate Nursing Programs
Get additional information about our Graduate Nursing Programs.
Nursing: Healthcare Systems LeadershipNursing

redpajama_set_name: RedPajamaCommonCrawl


There are so many occasions in our lives that are so much worth celebrating and that too on a huge scale. Some occasions that are just so special that we don't just celebrate them every other day or month are the occasions worth remembering.
To make these occasions big and memorable in life, we obviously need to think big and different because these are not everyday occasions that we are talking about. These occasions could be anything from being your anniversary to your birthday to just a special day that you want to remember for the rest of your life.
While there are a million ways to make these stupendous occasions memorable, the one thing that always stands out and is always waited for, is definitely the cake. Everyone loves cakes. They're delicious and sweet and so much tasty that every time we eat cake, we feel like we're in some highly privileged part of heaven. It's true, isn't it? Cakes make us feel happy because they are different than all the other kinds of deserts or sweets that we have available otherwise.
These days when we plan on buying a cake, we are always too excited because unlike earlier times, we can now customize our cakes. We can get picture printed cakes, cakes with different designs, in different shapes and customizable flavors too. We can simply get the cake in whatever shape, size and color that we want it to be. It has become so easy to grab on to such cakes these days that we don't really need to go the extra mile just to customize a cake.
Such cakes are available at every nook and corner with so much ease that you wouldn't even have ever imagined before. So we don't need to think much when it comes to getting the best cake for the most special life occasions that occur in our lives. To get the best and the tastiest cakes, we certainly have to spend quite a bit. Sometimes, the cake that we like is so exotic and rare that it definitely costs us a bomb to get it over for our birthdays or anniversaries. When the situation is like that, we obviously tend to skip out that cake because it's super costly. This part shouldn't worry you anymore because we, at Paylesser UAE , have got some amazing coupons for you to use which will reduce your expenditure on cakes , unbelievably.


Chicago, IL, September 06, 2018 --(PR.com)-- Dr. Donna L. Irvin of Chicago, Illinois has been honored as a Woman of the Month for August 2018 by P.O.W.E.R. (Professional Organization of Women of Excellence Recognized) for her outstanding contributions and achievements in the field of Human Resources. Each month women are featured to represent their professions and industries due to their expertise and success in their chosen specialty.
Dr. Donna L. Irvin is the Chief Operating Officer at MyHrFactor, Incorporated. This company generates an electronic job board that specializes in matching human resources to employer electronic job postings. Myhrfactor.com uses a custom algorithm based on the company's desired human traits and matches those traits with questions asked of potential candidates to derive a mathematical score or factor.
With over 7 years of experience, Dr. Irvin is the behavioral algorithm designer for the human resource website. She earned her Ed.D. in Organizational Leadership, with a specialty in Business from Argosy University in 2015.
Dr. Irvin is a member of the Sigma Beta Delta Business Honor Society. She published a study of "The Impact of Baby Boomer Military Veteran Leaders on Non-Military Generation Y Employees." In her spare time she enjoys designing jewelry and glass blowing.
For further information, contact www.myhrfactor.com.
P.O.W.E.R is a website as well as a digital and print magazine featuring professional and famous women. Our mission is to provide a powerful network of empowering women who will mentor and inspire each other to be the best they can be. Through our valuable services, our members can collaborate with like-minded professionals, gain recognition and obtain knowledge from those who have already achieved success.


The 2016 model Lincoln Navigator presents to the public an offering of prestige and elegance. Compared to similar-sized competitors, the Lincoln Navigator shows a healthier price point without missing any of the luxury or amenities.
While the jump from the 2014 Navigator to the 2015 design presented some major upgrades, the 2016 model year (the last of the "Third Generation" line) isn't a far departure from the previous year's model. Aside from some slight body modification and paint choice, the 2016 is a carryover from the last year.
The Lincoln Navigator has become the top choice of celebrities and mainstream consumers alike. Although its body style is reminiscent of past SUV design, the Navigator nonetheless offers major quality, luxury and performance.
Last year, Lincoln switched from a V8 to a vastly improved 3.5-liter EcoBoost V6. The turbocharged engine improves acceleration and fuel economy, and its EPA-estimated 16 mpg city and 22 mpg highway put it ahead of many of competitors. Don't let the size of the engine fool you, this vehicle still puts out an impressive 380 horsepower with 460 pound-feet of torque for towing capacity of up to 9000 pounds.
Regardless of the updates to the Navigator some might say it is an old guard choice when compared to more modern contemporaries, but one look at the entire package and you will see that this couldn't be further from the truth. Even with the base Select package, the Navigator presents top-of-the-line luxury.
The Select package ($63,090 MSRP) offers luxury features including a power lift gate, power running boards, temperature-controlled front seats, power-folding third-row seats, a THX II audio system with fourteen speakers subwoofer and surround, SYNC 3, satellite radio, HID headlights, genuine wood trim and an instrument panel wrapped in leather.
The Reserve package ($71,150 MSRP) adds a rich two-tone exterior, 22-inch alloy wheels, and upgraded interior materials and colors. Standard safety features include trailer sway control, tire pressure monitoring, front and rear parking sensors with a rear camera, blind spot detection with cross traffic alert, LED brake lights, hill hold and descent control, side-impact airbags for front-seat occupants, and side curtain airbags inclusive of all three rows of seats.
The 2016 Lincoln Navigator offers luxury, class and efficiency that make it a good value for its price point versus its competitors. Its functionality, class and amenities in the Select and Reserve offerings make this a good buy for the savvy consumer.
While the Select package offers an excellent value for the consumer, the step up to the Reserve package is worth the investment. It keeps the upgrade price under $10,000, which is well worth the value to someone in the market to purchase a high-end luxury SUV.


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Chocolateria
Interpretation Center of Chocolate
The History of the chocolates of "La Cepedana"
Since 1903, throughout 3 generations, we have been dedicated to the chocolate industry in Astorga.
Lorenzo Cabezas Álvarez 1903
Pedro Cabezas Fernández 1950
Alfredo Cabezas Galán 1971
The History of the chocolates of "La Cepedana"
Before the eighteenth century, workers came to Astorga from other provinces to learn the craft of making chocolates. Astorga was famous at the time for making chocolates by stone.
The origins of the artisan in Astorga is due to the Maragatos Arrieros that transported the fish from the Galician ports to Madrid. They discovered a few cacao beans in the port and brought it to Astorga. Then the chocolate began to be manufactured.
At that time, a worker only produced 30 or 40 pounds of chocolate a day.
It is worth noting that Spain was a pioneer in chocolate production and passed it on to the rest of Europe with the marriage of Princess Anne of Austria with Louis XIII King of France.
At that time, attending a meeting where chocolate was tasted was an honor, since it could only be tasted in meetings of high economic and political status.
GRANDFATHER LORENZO AND HIS SON PEDRO
One day in 1903 Lorenzo Cabezas Álvarez, who came from a family of farmers, out of curiosity decided to test out different types of chocolate with one of his friends who originally taught him how to make chocolate.
To do this, they used an oval stone and a roller.
We were the first chocolate Factory in región known as "La Cepeda". For this reason we decided to call ourselves "Chocolatería La Cepedana". We have been offically recorded in history since 1920.
Lorenzo was the pioneer of the "Chocolatería La Cepedana". He first began making chocolate in Sueros de Cepeda and around 1922 he moved to Astorga. He lived on a street called "Bajada de la Estación"; now called "Pedro de Castro" street. He began his workshop with 2 basic machines. They were a mixer made from stone rollers called "GALET" and a refiner which was also made from stone rollers. The stone rollers moved mechanically through pulleys that moved it to a transmission.
Gradually the machines became more modernized and starts making "SWEETS" and "CANDY". His son PEDRO only took care of the commercial portion of the industry until he had to take care of the business portion as well after the passing of Lorenzo in 1950. Pedro continued the production of chocolates until he decided to pass on his work to his son Alfredo when he had retired in 1971.
THE THIRD GENERATION
Alfredo continued to develop the industry and in 1973 he bought the brand "SAN MARCOS" from VDA DE CASIMIRO DIEZ DE LEÓN when he ended his career. Soon, Alfredo had began to pack the chocolates together with the logo "La Cepedana". In 1983, he bought the factory of Unión de Fabricantes de Mantecadas located on the Carretera Madrid Coruña 350 in the city of Astorga. He moved the production of chocolates there as well as the production mantecadas, puff pastry and homemade candy. He also bought the brands "LOS MARAGATOS" and "LA VEGA" and their machines in 1978. Alfredo had purchased them from D. Isidoro Geijo (a craftsman).
Now Alfredo has retired he has passed on his life's work to two of his workers with whom he has closely worked with for many years. They are María del Carmen and Francisco and they continue to work nonstop to continue the store's legacy.
On the other hand, it maintains a shop in the Located in the center of Astorga "LA CHOCOLATERÍA DE LA CEPEDANA" sells all kinds of chocolates and sweets from our own factory, as well as souvenirs. Here you can even taste our fabulous cups of chocolate.
© 2017 Chocolateria La Cepedana | Aviso Legal


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El Campeonato Cearense de Futsal es una competición realizada por clubes de fútbol sala del estado de Ceará desde 1956. Es organizado por la Federación Cearense de Fútbol Sala (FCFS).

Palmarés

Títulos por equipo

Referencias

Enlaces externos
 Sitio oficial

Fútbol sala en Brasil
Campeonatos de fútbol sala entre clubes

redpajama_set_name: RedPajamaWikipedia


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One of the toughest tasks that handicappers face today, especially in light of all the turf and synthetic races carded on a daily basis, is estimating what the pace of a race is likely to be. Will the frontrunners rush to the front in an all-out sprint for early supremacy or hold back like kids in line for a flu shot?
In last Saturday's Fountain of Youth Stakes, the former approach was on display, as Majestic Hussar rocketed to the front and recorded a -13 early speed ration, carving out an opening half-mile in 45-2/5 seconds.
Of course, after the race, when it was discovered that the 3-5 favorite Violence had fractured his right front medial sesamoid and is no longer on the Kentucky Derby trail, many theorized that the swift Fountain of Youth pace contributed to his demise.
Yet, it is my contention that the -13 Fountain of Youth ESR was not only a non-surprise, it was predictable. In fact, I'm going to show you an easy and reasonably accurate (hey, you can't expect easy and infallible, can you?) method for determining the probable pace of a race.
Now, as you probably guessed, I'm going to use my proprietary speed rations to do it… but don't be discouraged by that fact. I am only using my numbers to draw measurable conclusions. From a handicapping standpoint, the important thing is discerning whether the pace figures to be fast, normal or slow — which is something my ESRs can readily tell us.
In fact, the crux of this method lies in a different set of digits altogether — the Quirin speed points found in Brisnet's Ultimate and Premium Plus past performances or detailed by the man himself in "Winning At the Races." The concept is simple: Just total up all the Quirin speed points in a given race and divide by the number of horses that earned them (first-time starters or horses with zero points should be ignored). Then use the equations derived from my database studies (below) to forecast today's ESR. Because the ESRs are relative, i.e. they are not speed figures, one can instantly get a grasp of how the race is likely to be run once they have been obtained.
Let's go back to last weekend's Fountain of Youth Stakes and put this simple pace method to the test.
Eight horses (Joshua's Compromise wasn't considered — see above) combined to earn 42 Quirin speed points, good for a race rating of 5.3 (42/8= 5.3).
ESR(y)= -0.5877 * 5.3(x) – 7.0519, or -10.
A -10 ESR, as noted above, constitutes a "brisk" pace. Yeah, in real life, the Fountain of Youth pace turned out to be a little faster than that (almost "demanding"), but we're in the ballpark. And that's all this method is attempting to do — give us a general idea as to how fast, relatively speaking, the pace will be.
With this knowledge, we might have concluded that horses able to rate off the early fractions — horses like Orb, Joshua's Compromise, Violence and, to a lesser degree, He's Had Enough and Sr. Quisqueyano — would have an advantage in Saturday's Gulfstream Park feature.
And we'd have been right.
Orb rallied from eight lengths off the pace to catch a leg-weary Violence in the final strides, while Speak Logistics, a frontrunner that has been attempting to rate in recent races, rallied to finish third.
Try this method on other races and see what you think. Hopefully, it will help you more accurately assess the pace picture of the races you bet on, which should help your ROI… and your peace of mind.
Very interesting, thanks for posting...will definitely look to study it further. Why did you multiply by 5.25 instead of 5.3?
I need to change that Larry. I just rounded in one instance and not in another.
The other thing I noted on my Facebook page -- and I'll look into this further -- is to examine, say, the top 3-4 top Quirin point-getters and use THEM as the basis of the pace assessment.
Derek, this is really helpful. Thanks for the explanation. I have one quick question. The formula for Turf Routes adds the final amount (0.1399) to the calculated figure. Is this correct? The reason I ask is that in all the other formulas, the final amount is subtracted from the calculated figure. Thanks.


text:
Primary endpoint met in the CLEAR Outcomes Trial of bempedoic acid showing statistically significant relative risk reduction in major adverse CV events
Successful topline results from the CLEAR Outcomes Trial demonstrate that bempedoic acid, marketed as NILEMDO®▼ in Europe, reduces the risk of serious cardiovascular (CV) events in patients with, or who are at, high risk for atherosclerotic cardiovascular disease (ASCVD) with elevated LDL-C levels1,2
The results position bempedoic acid as the first oral ACL inhibitor acting as a lipid-lowering therapy, known to reduce both LDL-C levels and risk of major adverse CV events1,2
Comprehensive data will be presented at a key medical congress in the first quarter of 2023
MUNICH, December 08, 2022--(BUSINESS WIRE)--Daiichi Sankyo Europe, (hereafter, Daiichi Sankyo) announced today that the primary endpoint was met in the Phase 3 cardiovascular CLEAR (Cholesterol Lowering via Bempedoic acid, an ATP citrate lyase (ACL)-Inhibiting Regimen) Outcomes Trial, demonstrating statistically significant relative risk reduction in major adverse CV events (MACE-4) in patients treated with 180 mg/day bempedoic acid compared to placebo (with no or very low statin background).1,3
Comprehensive data from the CLEAR Outcomes Trial, led by US-based biotech company Esperion Therapeutics Inc., will be presented at a key medical congress in early 2023 and subsequently submitted to applicable regulatory authorities. The initial findings from the data indicate that bempedoic acid is the first oral, ACL inhibitor known to reduce both LDL-C levels and risk of major adverse CV events.1 The findings are congruent with previous significant evidence and the latest clinical guidelines highlighting that the lower a person's LDL-C level, the lower their cardiovascular risk.4
"The positive results from the CLEAR Outcomes Trial represents a pivotal step towards reducing the impact of CVD in Europe for patients who are currently at high risk of heart attack and stroke," said Professor Kausik Ray, Professor of Public Health and President of the European Atherosclerosis Society, Honorary Consultant Cardiologist, Director ICTU Global and Deputy Director of the Imperial Clinical Trials Unit at Imperial College London. "I am very excited to see more data from the trial over the coming months and better understand how bempedoic acid can continue to help clinicians bring LDL-C levels of patients to guideline-recommended goals and thus reduce the impact of cholesterol on CV health in Europe."
"With 10,000 lives lost everyday to CVD in Europe, we are truly encouraged by this new data, which demonstrates that bempedoic acid does reduce the risk of serious CV events for patients who are at high-risk of experiencing a heart attack or stroke,"1,4 said Dr Stefan Seyfried, Vice President Medical Affairs Specialty Medicines, Daiichi Sankyo Europe GmbH. "We look forward to sharing additional analyses and insights, as well as working closely with the scientific and clinical communities, to better understand how the data can support their care for CVD patients across Europe."
CLEAR Outcomes was a Phase 3, event-driven, randomised, multicenter, double-blind, placebo-controlled trial designed to evaluate whether treatment with bempedoic acid reduced the risk of CV events in patients with or who are at high risk for ASCVD with documented statin intolerance and elevated LDL-C levels (fasting blood LDL-C ≥ 100 mg/dL (2.6 mmol/L)).3 The study, which was fully enrolled in August 2019, included 14,014 patients at over 1,200 sites in 32 countries. Patients had at least 36 months of follow-up.3
About bempedoic acid
Bempedoic acid (commercialised in the European Economic Area, Turkey and Switzerland as NILEMDO®▼) is a first-in-class, oral treatment which lowers cholesterol, and which can be combined with other oral treatments to help lower cholesterol even further.2,5 Bempedoic acid inhibits ATP citrate lyase (ACL), an enzyme which is involved in the production of cholesterol in the liver.2
Bempedoic acid has been approved for use in adults with primary hypercholesterolaemia (heterozygous familial and non-familial) or mixed dyslipidaemia, as an adjunct to diet:2
in combination with a statin or statin with other lipid-lowering therapies in patients unable to reach LDL-C goals with the maximum tolerated dose of a statin, or
alone or in combination with other lipid-lowering therapies in patients who are statin-intolerant, or for whom a statin is contraindicated.
Bempedoic acid acts on the well-known cholesterol synthesis pathway, upstream of the statin target in the liver, which allows additional LDL-C lowering when added to statin or other lipid-lowering therapies. Due to its unique mechanism of action, bempedoic acid is not activated in skeletal muscle.
Daiichi Sankyo Europe has licensed exclusive commercialisation rights to bempedoic acid in the European Economic Area, Turkey and Switzerland from Esperion and is the full Marketing Authorisation Holder in these territories.
About Daiichi Sankyo
Daiichi Sankyo is dedicated to creating new modalities and innovative medicines by leveraging our world-class science and technology for our purpose "to contribute to the enrichment of quality of life around the world." In addition to our current portfolio of medicines for cancer and cardiovascular disease, Daiichi Sankyo is primarily focused on developing novel therapies for people with cancer as well as other diseases with high unmet medical needs. With more than 100 years of scientific expertise and a presence in more than 20 countries, Daiichi Sankyo and its 16,000 employees around the world draw upon a rich legacy of innovation to realise our 2030 Vision to become an "Innovative Global Healthcare Company Contributing to the Sustainable Development of Society."
For more information, please visit www.daiichisankyo.com
▼ This medicinal product is subject to additional monitoring.
1 https://www.esperion.com/news-releases/news-release-details/esperion-announces-clear-cardiovascular-outcomes-trial-nexletolr.
2 European Medicines Agency. NILEMDO Summary of Product Characteristics. Available at: https://www.ema.europa.eu/en/documents/product-information/nilemdo-epar-product-information_en.pdf. Last accessed December 2022.
3 Nicholls, S.J., et.al. Rationale and design of the CLEAR-outcomes trial: Evaluating the effect of bempedoic acid on cardiovascular events in patients with statin intolerance. Am Heart J. 2021. 235: 104–112.
4 The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and European Atherosclerosis Society (EAS). ESC/EAS guidelines for the management of dyslipidaemia. Eur Heart J. 2020. 41(1):111–188.
5 SwissMedic. NILEMDO (bempedoic acid) Product Information for Human Medicinal Products. Available at: https://www.swissmedic.ch/swissmedic/en/home/about-us/publications/public-summary-swiss-par/public-summary-swiss-par-nilemdo.html. Last accessed December 2022.
Dr. Wolfgang Schiessl
Daiichi Sankyo Europe GmbH
PR & Portfolio Communication Lead, Specialty Medicines
Fall Out Boy Announces Massive Summer Tour — Band's First Since Joe Trohman's Temporary Exit
The 55 Best Valentine's Day Gifts to Give Her This Year
These romantic Valentine's Day gifts for women are perfect for your girlfriend, wife, mom, or friend, and will make her feel the love then and beyond. Whether she takes Valentine's Day very seriously or is more laid back about grand gestures, you'll find a gift for her that will make her smile and feel all the love. Many of these are top gifts for wives and best-selling presents for girlfriends, but we know that Valentine's Day isn't just for lovers, so we've also added some ideas that would be perfect for a BFF on Galentine's Day or a good gift for your mom.
TRAVERSE CITY, Mich., January 31, 2023--ATLAS Space Operations today announced that it is the first provider to join the Amazon Web Services (AWS) Solution Provider Program (SPP).
More than a million people took to the streets of France on Tuesday, protesting President Emmanuel Macron's plans to raise France's retirement age from 62 to 64 by 2030. Photo: Valery Hache/AFP/Getty Images
The Grammy-nominated rock band is hitting the road in support of the upcoming album So Much (For) Stardust
CAMBRIDGE, Mass., Jan. 31, 2023 (GLOBE NEWSWIRE) -- Catalyst Partners Acquisition Corp, (the "Company") announced today that, due to its anticipated inability to consummate an initial business combination within the time period required by its Amended and Restated Memorandum and Articles of Association, the Company intends to dissolve and liquidate in accordance with the provisions of its Amended and Restated Memorandum and Articles of Association and will redeem all of the ordinary shares outst
Legislation, Not Standards, Key to Fixing Long-Term Care
OTTAWA, Ontario, January 31, 2023--New long-term care standards released today will only be useful if the Liberal government keeps its promise to give them the force of law, according to the Canadian Union of Public Employees, which represents 90,000 workers in long-term care.
Entegris to Report Results for Fourth Quarter of 2022 on Tuesday, February 14, 2023
BILLERICA, Mass., January 31, 2023--Entegris, Inc. (NASDAQ: ENTG), will release its financial results for the fourth quarter of 2022, before the opening of the market on Tuesday, February 14, 2023. A teleconference with management is scheduled for the same day at 10:00 a.m. Eastern Time.
Rep. George Santos quits House committee seats amid uproar over lies: What we know
Republican George Santos, amid calls to step down from Congress, resigned from two House committees a day after meeting with Speaker Kevin McCarthy.
Mason Industrial Technology, Inc. Will Redeem Its Public Shares and Will Not Consummate an Initial Business Combination
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ApartmentLove Raises $415,000 in Final Tranche of Brokered Private Placement led by Canaccord Genuity
NOT FOR DISTRIBUTION TO UNITED STATES NEWSWIRE SERVICES OR FOR DISSEMINATION IN THE UNITED STATES TORONTO, Jan. 31, 2023 (GLOBE NEWSWIRE) -- ApartmentLove Inc. (CSE: APLV) (OTCQB: APMLF) ("ApartmentLove" or the "Company"), a leading provider of online home, apartment, and vacation rental marketing services to property managers, owners, renters, and vacationers in more than 30-countries around the world, is pleased to announce that, further to its press releases dated November 3, 2022, and Decemb
Exco Results for First Quarter Ended December 31, 2022
Consolidated Sales of $139.1 million increased 38% compared to prior year quarter. Net Income of $4.5 million and EPS of $0.12 EBITDA of $15.2 million compared to $9.3 million prior year quarterQuarterly dividend of $0.105 per common share to be paid March 31, 2023 TORONTO, Jan. 31, 2023 (GLOBE NEWSWIRE) -- Exco Technologies Limited (TSX-XTC, OTCQX-EXCOF) today announced results for its first quarter of fiscal 2023 ended December 31, 2022. In addition, Exco announced a quarterly dividend of $0.1
Amcomri Entertainment's 'Left Behind: Rise of the Antichrist' Shines on Opening Weekend with Top 10 Performance at the North American Box Office
Theater chains extend initial run and expand to more screensVANCOUVER, British Columbia, Jan. 31, 2023 (GLOBE NEWSWIRE) -- Amcomri Entertainment Inc. ("Amcomri" or the "Company") (NEO: AMEN) (Frankfurt: 25Y0) (OTC: AMNNF), a global producer and distributor of independent movies, TV series and documentaries, has today confirmed that it's feature film production, 'Left Behind: Rise of the Antichrist', released on Thursday, January 26th, achieved an Opening Weekend Box Office in excess of US$3 mill
Largest Power Distribution Company in Denmark Selects the Copperleaf CNAIM Solution for Asset Investment Planning
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Multi-Met Receives First Payment Under Joint Venture Agreement on Bleiberg Property, Austria
Vancouver, British Columbia--(Newsfile Corp. - January 31, 2023) - Multi-Metal Development Ltd (TSXV: MLY) (OTC Pink: MLYCF) (formerly American Cumo Mining Corporation) and its subsidiary Poly Resources LLC (POLY) are pleased to announce that POLY has received the initial payment under the terms of the Joint venture agreement (previously announced In News Release dated October 26, 2022) with Battery Age Minerals (formerly Pathfinder Resources Ltd.) an Australian public company. A total of $50,00


A luscious Syrah from the south of France that's made from older, 30 year old vines. The yields are low at harvest and all the fruit is hand-harvested and minimally sulphured. The resulting wine is nothing short of stunning with black fruit aromas, peppercorn alongside great structure. Partially aged in old casks before bottling.
In the southern French village of Mont Blanc a pair of brothers named Aymeric and Jordan Amiel are making some beautiful music indeed. Not literally, mind you, but the kind you can pour into a glass. This intense, but nuanced expression of Syrah sings of rich crushed blackberry and plum, pepper and spice, wild flowers and a hint of smoked meat. The Amiel family has been making wine since the the 1400's, so it's no surprise that the brothers inherited a talent. But what is noteworthy is their insistence on keeping their winemaking as natural and non-invasive as possible. Sadly, the Languedoc-Roussillon region in which their estate lies has become better known for large scale production of average wines, so enjoy the exception to the rule. Food pairing? Break out the cassoulet!
Notify me when "A Peïssou", Dom. des Amiel - 2016 is back in stock.


The name Vaughn is of Welsh origin, and means small. The table below indicates the number of times the name Vaughn has been given to baby boys in recent years. The last 125 years refers to 1880 through 2004; last year refers to 2004. The rank and count values are based on U.S. Social Security Administration counts for the one thousand most popular names given to baby boys in each of these years.
The table below indicates the number of times the name Vaughn has been given to baby boys and baby girls each year, from 1880 through 2004. Vaughn first appeared in the top thousand boy or girl names during 1881, which is the first year shown on the table. A blank entry indicates that the name did not rank among the top one thousand names given to boys or girls, respectively, during the specified year.
During the last 125 years, parents have used Vaughn as a boy's name nearly 100% of the time and hardly ever as a girl's name. Cumulative counts and total counts shown on the above tables are slightly lower than actual counts because the name Vaughn appears in the top 1,000 boy names only 112 times during the last 125 years.


Managing Director of Bowhill Engineering was awarded the Industry Leaders Grant to aid him in attending a Leadership training course at Mt. Eliza Business School.
Click here to read a detailed description of Jeremy's experience with the program.


Ewa Beach Family Home - 300 Feet to Pu'uloa Beach!
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Sometimes it's great to travel without any plans, but even the most spontaneous travelers will want to have a basic understanding of just where Ewa Beach sits on the map.
You'll discover it approximately 10 miles west of Honolulu, the state capital of Hawaii, and about 4 miles south of Waipahu.
So, where to go first? The USS Arizona Memorial, a truly impressive sight, lures throngs of tourists to Ewa Beach each year. You'll want to stick it right at the top of your agenda.
This area is home to terrific attractions, like Pearlridge and Wet'n'Wild Hawaii.
Learn some new facts at Hawaiian Railway Society. The railway has never been so much fun! Want some more options? Whether you're an amateur or a budding pro, you'll love Coral Creek Golf Course. Grab your favorite clubs and see if you can improve your average. But there's more! Chip, pitch, drive and putt around Hawaii Prince Golf Club for a great day beneath the sun.
Hi there, globetrotter. We know you want to get the most out of your vacation, so why not check out car rentals in Ewa Beach? Book with Orbitz and get your adventure on the road today!
Escape Daniel K. Inouye International Airport minutes after landing by collecting a vehicle from one of the nearby outlets. Budget and Avis are both not far away from baggage claim.
Renting a vehicle in Ewa Beach means traveling out to one of the surrounding neighborhoods. Make a beeline for Western Honolulu, the home of Economy Rent a car at 4299 Lawehana Street.
Unfortunately, there are no available accommodations in Ewa Beach itself. But don't worry! Sitting 4 miles away, Pearl Harbor has a decent range. Some of our favorite choices include the Airport Honolulu Hotel and Best Western The Plaza Hotel.
Navigating airports can be a hassle, but the getaway at the end of that long plane ride is always worth the effort. Daniel K. Inouye International Airport (HNL) is the closest to Ewa Beach. It's located 6 miles east of the downtown area.
Located 18 miles from Ewa Beach, Haleiwa is adored by locals and travelers alike. Stop by this place to access Banzai Pipeline and the Dole Plantation, two leading attractions that are bound to impress. Just 18 miles away is another neighboring destination that's well worth visiting. Kailua (Oahu) is a handy place to access popular attractions like Lanikai Beach and Kailua Beach.
Whether you've had a complete turnaround or your plans have shifted for a different reason, we won't whack you with a fee if you need to cancel or change your booking. As we can't speak for your chosen airline or hotel, it might pay to check with them as soon as you're able to.


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This is an expanded response to John B.'s posted comment on a Standard-Times, New Bedford, article by Steve Urbon titled: "Petition seeks closing of NOAA fisheries regional office", a comment in which John B. states that the New England fishermen's troubles are due to "over harvesting" and that "NOAA is not the cause of the fishermen's troubles.", NOAA's role he contends, "…is only the bearer of bad tidings" and so NOAA then, quite innocently, didn't "cause" any of this mess; instead, he warns fishermen that "…unless the [fishing] industry takes an unflinching look at the realities that it is facing" or, "Ignore the realities, and the New England fishing industry may well go the way of Newfoundland's, which fished itself out of existence some years ago." http://www.southcoasttoday.com/apps/pbcs.dll/article?AID=/20130221/NEWS/302210353
John, there's that old familiar refrain again, "…too many fishermen chasing too few fish", overfishing, over harvesting? No, sorry, that's not "…an unflinching look at the realities" that's an ENGO talking point. This fishery is a disaster due to inadequate surveys and ambivalent assessments, plus the fact that many fishermen were put out of business by cock-eyed catch share allocations and the consequent fleet consolidation imposed by NOAA's EDF Jane Lubchenco and sustained by lawsuit threats from such enviro-luminaries as Conservation Law Foundation, Pew, Oceana, Center for Biological Diversity, and the Natural Resources Defense Council, to name a few.
Fishermen's troubles are a direct result of mismanagement: inadequate science, unreasonable Maximum Sustainable Yield-crisis centric regulations, NOAA's single species approach to a complex multi-species fishery, and then, of course, our beloved "returning profitability to fishermen" catch shares, a disastrous campaign to privatize and turn the fish resource into a Wall Street commodity at the expense and demise of working fishermen. Additionally, NOAA has traditionally ignored environmental factors, such as climate change, predation, and natural cycles, focusing solely on managing the fishermen, not the fish in their environment. If this cod stock is indeed "collapsing", it is certainly not due to "over harvesting"—the groundfish managers' Total Allowable Catch has been under-harvested for years, sometimes by 75%, but consistently underfished by at least 50%.
NOAA's responsibility goes way beyond simply being the "bearer of tidings". NOAA has now micro-managed the fishermen almost completely out of existence. These "troubles" are not caused by coastal small boat fishing operations following a business plan of "over harvesting".
NOAA, steered by the ENGO's, has mis-managed this groundfishery for decades. Simplistic Maximum Sustainable Yield management of a complex multi-species groundfishery has contributed greatly to the undermining of stock stability. MSY jeopardizes a stock's reproductive ability by encouraging the take of large prolific egg bearing fish, and then estimating stock population health by counting the recruitment of juveniles. It is the large mature fish in the stock population that influences stock stability and health. Managing from the MSY perspective does nothing but remove large fish from the stock, replacing them with a large class of young fish which assures stock population volatility.
As for Newfoundland's cod fishery, it was shut down in 1992. Arguably the collapse was a result of the previous decades' freezer/trawler excesses. National Sea Products, Ltd. a large Canadian integrated fish company, for example, operated several large capacity trawlers in the post 200mi. limit bonanza of the late 70's and 80's. In 1987 National Sea Products, Ltd. generated more than $450 million in annual sales, employed 8,000 workers, and executed fishing operations in all four Atlantic Provinces and three U.S. states in addition to its growing overseas units. As a result of this increased industrial style fishing pressure the average size of the fish decreased and they became harder and harder to find until the Canadian government closed the fishery in 1992. The smaller private fishing operations were penalized for the industrial offshore factory freezer/trawler fleet's activities.
The Newfoundland cod collapse is in no way analogous to what's going on in the dismantling of our fishery here in New England. The only parallel is perhaps between the Canadian Department of Fisheries' faulty management posture, (i.e., inviting in Canadian and foreign industrial exploitation) and the similar posture of NOAA's promulgation of catch shares quota management. NOAA's push for catch share ITQ consolidation is similar Canada's opening the door for exploitation by companies like Canada's National Sea Products, Ltd., and NOAA's push could have an even worse result of collapsing more species than just cod. NOAA it seems is in the process of privatizing all of our fisheries, and is currently working on catch shares for Monkfish.
When any fish becomes a tradable commodity on the "open market" a global moneyed-monster such as the Pacific Andes' China Fishery, with limitless "market capitalized" resources, can buy up limitless amounts of quota and with input restrictions and daily limits removed, they can bring in their factory trawlers and proceed to collapse the fish stocks. These huge integrated fishing companies also have a limitless appetite. They can always use more cod, more anything, to increase profit and bolster stock prices.
Industrialization is what caused the Canadian cod collapse and it will be the fate of all our local fisheries if NOAA's privatization plans are allowed to continue. Far from the independent fishermen "fishing themselves out of existence", it's the choking regulations and fleet consolidation which is clearing the way for the financialization/industrialization of the fish and the ocean environment. This is what is destroying the vital New England fishing industry.
Faulty MSY management, quota give-away consolidation, and only-profit-matters exploitation by market-capitalized companies, causes collapse, not the efforts of independent family owned coastal fishing boats.
NOAA should stick to weather forecasting and navigational charting and give fisheries management over to a Department of Fisheries employing some personnel that know and care something about fishing.
From the petition to close NOAA's office in Gloucester, MA: "On January 26, 2013, the Associated Press reported that John Bullard, the Northeast Regional Administrator for the National Marine Fisheries Service (NMFS), stated, 'failures by fishery managers are ultimately to blame for weak stocks that haven't rebounded.' The AP went on to quote Mr. Bullard as saying, 'we set the rules and clearly the rules have failed. There's no other conclusion.'"
How refreshing! The above statement by Bullard, aside from the discovery by the Inspector General of the corruption in the NOAA Office of Law Enforcement and the consequent reparations by Secretary Gary Locke, is the first time anyone at NOAA Fisheries has even approached admitting the "realities" of NOAA's management failures. Usually NOAA gives off self-congratulatory statements like those from departed Under Secretary Lubchenco declaring on her way out how she saved the fish and returned the fishing industry to prosperity.
However, when this petition attempts to take the NOAA director's admission of regulatory failure into actions which might actually fix some of the faulty management and get some relief to the fishermen who have been most harmed, Bullard responded to Steve Urbon in the Standard-Times article with: "this is very serious business that we're dealing with, and that petition is not serious. So I don't want to waste any time on it." (Pat Kurkul could very well have said these things—we didn't need a new regional director for this kind of disrespect!)
From the Petition:
"By closing the Northeast Regional Office in Gloucester and redirecting these funds to relief and programs benefitting the Northeast groundfish fleet, the Committee [Senate Committee on Appropriations] stands to support and advance important scientific research, particularly cooperative research and surveys conducted by non-NMFS scientists – such as those where fishermen are working together with the University of Massachusetts School for Marine Science and Technology (SMAST) and the Virginia Institute of Marine Science (VIMS), as well as much-needed more frequent assessments of the condition of managed species.
We further urge the Committee to reduce and redistribute current Regional Office operations to minimally staffed offices located in port communities such as New Bedford, Gloucester, and Portland so that necessary permits may still be issued as needed."
http://fishermen.wufoo.com/forms/close-the-nmfs-northeast-regional-office/
When the people who have been most harmed petition to mitigate the devastating effects of inept, "arbitrary and capricious", and the ENGO-agenda-driven "failures by fishery managers" by closing the office of origin from where, as Bullard admits, "…we set the rules and clearly the rules have failed"; and when they suggest in the petition that the rescued funds, resulting from such a closure, can be used for some long awaited Disaster Relief and also for supporting the trust-restoring remedy of stock assessments which are based on cooperative research and co-governance—that petition is not a "waste of time". In fact, it is quite serious.
End of article, comment here


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text:
Q: In PHP, is it more efficient to use a lambda expression for a callable than a string (or array)? In PHP, some function take a "callable" as an argument, meaning you can specify a function to be executed at some point down the line. One example is array_map.
PHP allows you to specify a callable in multiple ways, for example:
// as a string:
$lowerCaseStrings = array_map('strtolower', $arrayOfStrings);

// object methods as an array
// (this could be done with DateTime directly, of course):
class DateFactory {
    private $format;

    public function __construct($format) {
        $this->format = $format;
    }

    public function newDate($dateString) {
        return DateTime::createFromFormat($this->format, $dateString);
    }
}

$factory = new DateFactory('Y-m-d');
$dates = array_map(array($factory, 'newDate'), $arrayOfDateStrings);

// as a lambda expression / closure:
$dates = array_map(
        function ($dateString) {
            return DateTime::createFromFormat('Y-m-d', $dateString);
        },
        $arrayOfDateStrings
    );

Now, I figure that the latter form gets evaluated by the PHP engine once during compilation, while the other might be evaluated during runtime, probably for each call, meaning using a closure would be far more efficient for a large number of calls. Is that assumption correct?

A: I executed a function several different ways and recorded the run times.
It looks like using a string reference to a regular function is much more efficient.
Summary

*

*Normal function definition with array_map():
               4.001193714

*Lambda definition outside loop with array_map():
     10.1116962

*Normal function definition and call:
                              3.208938837

*Lambda definition and call within loop:
                      10.32323852

*Lambda definition outside loop:
                                   9.616424465

*Normal function definition and call_user_func():
        13.72040915

*Lambda definition outside loop and call_user_func(): 19.98814855

Normal function definition and call
$start_time = microtime(true);

function run_this() {
    // Empty function
}

for($i = 0; $i < 5000000; $i++) {
    run_this();
}

print "Execution time: " . (microtime(true) - $start_time) . "\n";

*

*3.1148610115051

*3.0175619125366

*3.5064949989319

*3.3637712001801

*3.0420050621033

Average: 3.208938837
Lambda definition and call within loop
$start_time = microtime(true);

for($i = 0; $i < 5000000; $i++) {
    $run_this = function () {
        // Empty function
    };
    $run_this();
}

print "Execution time: " . (microtime(true) - $start_time) . "\n";

*

*9.857855797

*10.07680297

*10.35639596

*10.51450491

*10.81063294

Average: 10.32323852
Lambda definition outside loop
$start_time = microtime(true);

$run_this = function () {
    // Empty function
};

for($i = 0; $i < 5000000; $i++) {
    $run_this();
}

print "Execution time: " . (microtime(true) - $start_time) . "\n";

*

*9.098902941

*9.580584049

*9.370799065

*9.90805316

*10.12378311

Average: 9.616424465
Normal function definition and call_user_func()
$start_time = microtime(true);

function run_this () {
    // Empty function
};

for($i = 0; $i < 5000000; $i++) {
    call_user_func('run_this');
}

print "Execution time: " . (microtime(true) - $start_time) . "\n";

*

*12.80056691

*13.47905684

*14.51880193

*13.79459596

*14.00902414

Average: 13.72040915
Lambda definition and outside loop and call_user_func()
$start_time = microtime(true);

$run_this = function () {
    // Empty function
};

for($i = 0; $i < 5000000; $i++) {
    call_user_func($run_this);
}

print "Execution time: " . (microtime(true) - $start_time) . "\n";

*

*18.99004483

*20.08601403

*20.52800584

*20.16949892

*20.16717911

Average: 19.98814855
Normal function definition with array_map()
$arr = array_pad([], 5000, 0);

$start_time = microtime(true);

function run_this () {
    // Empty function
};

for($i = 0; $i < 1000; $i++) {
    array_map('run_this', $arr);
}

print "Execution time: " . (microtime(true) - $start_time) . "\n";

*

*3.727953911

*4.213405848

*4.068621874

*4.180392027

*3.815594912

Average: 4.001193714
Lambda definition outside loop with array_map()
$arr = array_pad([], 5000, 0);

$start_time = microtime(true);

$run_this = function () {
    // Empty function
};

for($i = 0; $i < 1000; $i++) {
    array_map($run_this, $arr);
}

print "Execution time: " . (microtime(true) - $start_time) . "\n";

*

*9.418456793

*10.07496095

*10.1241622

*10.74794412

*10.19295692

Average: 10.1116962

redpajama_set_name: RedPajamaStackExchange


The no-cost, or low-cost, open source approach is intended to enlist a critical mass of health care users and developers, to use and enhance the OSCAR system on a ongoing basis. Any developments you make to OSCAR must be contributed back to the pool of OSCAR resources. To read more about how open source software functions, click here.
Oscar's objective is to offer a "royalty free" set of Clinic Applications and Clinic Resources for use by health care providers and clinics in Canada and everywhere.
How much will OSCAR's cost?
Oscar is developed using open-source tools, which are free of royalties.
There is no purchase cost, no license fees, no update/upgrade fees, no user fees.
Users only pay for their own clinic's hardware equipment, desired customizations and the support they need.
OSCAR has no "vendor". The term vendor implies a sale, yet OSCAR software cannot be sold. It has to be free. OSCAR's strong open source license ensures that it will always remain so. OSCAR simply is the finest EMR software no money can buy.
McMaster university holds the strong open source license for the majority of the code base in the OSCAR McMaster trunk. This means that Mc Master has copyright, and no one else may claim ownership of the project.
A growing number of independent commercial OSCAR support providers compete for the support business. These "OSPs" may levy fees for tech support, but none of them have rights to sell licenses to use OSCAR.
OSCAR uses the GPL license, specifically version 2 (GPLv2).
Do I need to be a "techie" to use open source OSCAR?
No. OSCAR is VERY easy to use. Any computer (or smart phone) with a browser can securely connect to your OSCAR server installation, either locally or remotely. The interface is intuitive and very easy to learn. All functions of this fully featured EMR are at your fingertips.
Do I need to be a "techie" to install open source OSCAR?
Yes. You most certainly have to be a techie to set up and install an OSCAR EMR system. If you consider yourself techie and feel confident about configuring a fresh Linux Server, downloading and installing the OSCAR .deb package from here, tweaking the MySQL database settings, sorting out teething issues, troubleshooting the external interfaces with lab and billing agencies, and you really do not wish to pay for support, then doing it yourself might seem tempting. There are a few technically savvy users out there who have chosen to do just that. However...think carefully before you elect to go it alone. You need to be fully aware of the implications regarding data integrity and security, and please don't underestimate the extent of IT experience required. Inexperienced self-supporting users may be taking risks with their patients' data and thus with professional liability. At OCUS we encourage our member users to enlist the help of a professional OSCAR support provider (OSP). Doctors are trusted with their patient's medical records, and this responsibility should be taken seriously. Your friendly OSP will help you keep your EMR running and safe. To find an OSP near you click here.
Keep in mind though that you do want to practice due diligence in choosing and carefully vetting your support provider. Experience matters.
What companies provide support to OSCAR in ON, BC and elsewhere?
Here is our list of commercial OSCAR support providers. This is not a complete list of all OSPs out there. Our listing policy is appended to the list. New OSCAR support providers are entering the market frequently. Some are companies with IT experience in other areas, and they see OSCAR as an opportunity to help deploy and support EMR systems for doctors and other health care professionals. Some OSPs focus solely on OSCAR support.
Some screen-shots are posted on this site here. Some OSCAR support providers or developer groups provide demo sites, these are full OSCAR installations open for the public to explore. The best possible demo experience is to visit an actual working OSCAR user near you and see a living, breathing OSCAR system. Generally OSCAR users embrace the opportunity to show their EMR off to interested colleagues and help them make good choices.
Join our discussion group on the OSCAR user mailing lists.
I am a programmer. How can I join the development team?
If you are programmer interest in getting involved you will find information to get you started here and here. You can also participate in the developer discussion list on Sourceforge.


Is Leeds the best Maine city for your business?
Now you can skip hours of internet research and jump straight to getting answers with our meaningful at-a-glance Demographics Spreadsheet Report. With the most current & most popular demographic data, it's the perfect starting point for your research about Leeds and the rest of Maine.
All Leeds population data above are from the US Census Bureau.
The population data for Leeds are from the Census' American Community Survey 2017 5-year estimates and the Census' 2017 Population Estimates. The demographic data for China, Morrill, Mount Vernon, Phippsburg, and St. Albans are the most current, comparable demographics available from the US Census Bureau, are from the American Community Survey 2017 5-year estimates, and were downloaded on 6 December 2018. Check out our FAQ section for more details.
With 2,300 people, Leeds is the 150th most populated city in the state of Maine out of 523 cities. But watch out, Leeds, because Phippsburg with 2,198 people and St. Albans with 2,172 people are right behind you.
The largest Leeds racial/ethnic groups are White (96.8%) followed by Two or More (1.5%) and Hispanic (1.3%).
In 2017, the median household income of Leeds residents was $53,705. Leeds households made slightly more than China households ($53,574), Morrill households ($53,594), and Mount Vernon households ($53,594) . However, 15.4% of Leeds residents live in poverty.
The median age for Leeds residents is 40.2 years young.
Looking for Leeds, ME Starter Report PDF? Click Here.


New to sales? There are a number of parts to every sale and it is important to get them right. Miss one out or get one wrong and your hit rate will suffer and so will your morale. We look at all the problems facing new people in sales who have to deal with receptionists and then build rapport with busy decision makers and have answers to objections that work. Our research shows that new salespeople who attend this course get off to a good start and go on to be successful.
This course will build a good foundation for those new to selling. Delegates will be able to handle receptionists and secretaries, get through to decision makers, develop rapport, overcome objections and win the business.


In memory of my Elliot.
A tribute to Zinnie, the sweetest German Shepherd on earth.
GSGSR received a gift for the Siggy Fund in memory of Don and Barb Wortman.
In loving memory of Gustopher - a gentle giant and devoted companion.
In memory of Bob Sisemore, a devoted GSD breeder/exhibitor, obedience & tracking judge.


text:
The potential for manipulating RNA with pentatricopeptide repeat proteins
Plant J. 2014 Jun;78(5):772-82. doi: 10.1111/tpj.12377. Epub 2014 Jan 29.
Yusuke Yagi 1 , Takahiro Nakamura, Ian Small
1 Faculty of Agriculture, Kyushu University, Fukuoka, 812-8581, Japan.
DOI: 10.1111/tpj.12377
The pentatricopeptide repeat (PPR) protein family, which is particularly prevalent in plants, includes many sequence-specific RNA-binding proteins involved in all aspects of organelle RNA metabolism, including RNA stability, processing, editing and translation. PPR proteins consist of a tandem array of 2-30 PPR motifs, each of which aligns to one nucleotide in the RNA target. The amino acid side chains at two or three specific positions in each motif confer nucleotide specificity in a predictable and programmable manner. Thus, PPR proteins appear to provide an extremely promising opportunity to create custom RNA-binding proteins with tailored specificity. We summarize recent progress in understanding RNA recognition by PPR proteins, with a particular focus on potential applications of PPR-based tools for manipulating RNA, and on the challenges that remain to be overcome before these tools may be routinely used by the scientific community.
Keywords: PPR proteins; PUF proteins; RNA binding; sequence-specific; synthetic biology; transcription activator-like effectors.
© 2014 The Authors The Plant Journal © 2014 John Wiley & Sons Ltd.
Plant Proteins / metabolism*
RNA, Plant / metabolism*
RNA-Binding Proteins / metabolism*
RNA, Plant
RNA-Binding Proteins


Having a clearly articulated plan that can be easily shared and understood is an important part in any organisation's path to success. This Strategic Planning Manual is a 2-day interactive workshop which enhances the understanding of strategic planning development.
The VMSA (or Vision - Measures - Strategies - Actions) model is a 4-phase, systematic approach to envisioning a desired outcome or future, and translating that vision into a set of measurable goals, strategies and action plans. The VMSA model is based on a hybrid of industry standard models and tools and has been carefully crafted for the Bruneian context in strategic planning development.
Participants will have the opportunity to develop a practical and implementable Strategic Plan using the VMSA model. Appropriate environmental scanning and foresighting tools will also be used in the formulation of a future-proof vision.
The workshop will be facilitated by Dr Sophiana Chua Abdullah. Dr Sophiana is fully trained and certified in Strategic Management (Haines Centre for Strategic Management Singapore) and has facilitated a number of workshops in Strategic Foresight and Strategic Planning for both the private sector and government organisations. She has also earned excellent feedback for the one-on-one coaching for a few ministries and departments in their strategic planning development endeavours.
Dr Sophiana has facilitated several workshops in the area of Change Management, Geographic Information Systems, Report Writing, Presentation Skills, Strategic Foresight and Strategic Management and Planning. Her strengths lie primarily in the one-to-one coaching.
Understand the flow and key phases of Strategic Planning development.
Understand the process of aligning and cascading a Strategic Plan in terms of measures, strategies and actions from throughout the organisational hierarchy.
Build a practical and implementable Strategic Plan using the VMSA model.
Participants learn through various interactive exercises and demonstrations designed to help them understand the full cycle of the strategic planning development process.
What is it? Who does it? What are the characteristics of successful strategic plans?
The 4 Phases of Strategic Planning development.
How to align a Strategic Plan from its vision to measures, strategies and action plans.
How to cascade a Strategic Plan from the top level down to the departmental/individual levels of the organisation.
How to apply the VMSA model, scanning and foresight tools to develop a practical and implementable Strategic Plan.
This training is suitable for middle level officers and will be invaluable to those directly involved in the planning, execution, review and monitoring of strategic plans.


text:
Дупка на пътното платно е сериозно и сравнително дълбоко, но локализирано нарушение на целостта на пътната настилка, принуждаващо отклонение на движението и частична или пълна загуба на функционалността на пътя. При всички видове пътни дупки основна причина за повредата е първоначална пукнатина вследствие износване на настилката и много често наличието на подкопаваща вода, при което част от използвания при изграждането на пътя строителен материал е отнесена или разрушена. Натоварени с трафик участъци, по които се движат несъобразено със заложените технически условия при строителството на пътя тежки моторни превозни средства, могат допълнително да станат обект на напуквания и прогресивно разрушаване на платното. Проблемите с наличие на вода по пътя са известни на магистрало-строителите още от римско време, като за целта пътищата са били изграждани от няколко пласта и им е бил придаван отводнителен профил с по-висока осева част и сравнително дълбоки канавки.

Образуване

Повечето дупки на пътното платно са образувани поради износване на пътната настилка. Късовете между пукнатините се разхлабват и могат да се отделят от повърхността, като по този начин се образува дупка. Възможно е такива дупки да се превърнат в т.нар. крокодилско напукване, разраствайки се. Любопитни явления в по-топлите държави са образуваните коловози в близост до стоп линията, където често спира трафикът в изчакване на зелен сигнал. Тежестта на автомобилите в комбинация с размекнатия от слънцето асфалт създава трайни вдлъбнатини, които са предпоставки за разрушаване на работния слой на пътя.

Образуването на дупки е допълнително "подпомогнато" от ниски температури – водата се разширява, превръща се в лед и оказва по-голям натиск върху вече пропукания път. Веднъж възникнала, дупката се разраства от транспортните средства чрез натрошаването на плътната асфалтова настилка на малки късове материал от баластра и асфалт и тяхното трайно отстраняване от пътното платно. Размерът на разрушения участък, може да бъде увеличен при запълване с вода, тъй като водата отстранява част от пътната повърхност, когато превозни средства преминават. В умерения климатичен пояс дупки често се образуват по време на пролетните дъждовни месеци, когато пътното платно е податливо на деформации заради високото съдържание на влага.

Според ефективността на местните служби за поддръжка на пътните инфраструктури, дупките на пътното платно могат да стигнат от сантиметри до около метър в ширина и от няколко, до няколко десетки сантиметра в дълбочина. От своя страна, според скоростните ограничения и спазването им, почти всички по размер пътни дупки могат да предизвикат щети на гумите и проблеми с окачването, като не са изключени и тежки пътнотранспортни произшествия (най-вече на автомагистрали). Дупките на платното понякога се забелязват трудно от водачите, особено при несъобразена скорост.

Източници

Външни препратки

 Уебсайт с възможност за подаване на сигнали за дупки на пътното платно
  Видеоклип, онагледяващ образуването на дупки


From $253,255 Why 'From' pricing?
With over 2,100 square feet of living space, this home is packed with options and room to grow. The first floor includes an open kitchen with optional island great room with optional fireplace, half bath and gorgeous sun room. Upstairs features a second floor laundry, master bedroom with private bath and walk in closet, two additional bedrooms, full bath, and a game room or optional fourth bedroom!
Rosetta Place is conveniently located in the highly desirable Mishawaka School District. Located just minutes from schools, shopping and dining, this community offers a great suburban lifestyle.
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