text:
The following list of quotes are from my son Patrick (age 5 age 6 age 8 as of March 2014). I feel that these were worth saving for posterity.
"Candy is evolution." (2009)
"My life is not at home, it's in another building." (11/13/2009)
"I'm not a blob, I've got bones." (11/7/2009)
Patrick: "Please Dad can I have a cheesestick?" Me: "Why?" Patrick: "Because I want one in my belly." (9/30/2009)
"Daddy, what continent do we live on?" (11/11/2009)
Seeming unpleased with tonight's cheese-filled shells and peas, walked away from the table and said, "I'm gonna wash my hands 'cause that's a stupid dinner." (1/18/2010)
"There's garbage everywhere. That's unhealthy for the Earth and it makes the Earth mad." (3/6/2010)
Patrick: "What is this?" (pointing to an insect on his placemat) Me: "A mosquito." Patrick: "What does it eat?" Me: "It drinks… what do you think it drinks?" Patrick: "Milk." (4/6/2010)
On Patrick having a handful of rocks when I picked him up from preschool. Me: "What is it about rocks that you like?" Patrick: "Because I'm a science kid." (2010)
On seeing Hubble IMAX: "I'm going to be an astronaut… No, I'm not going to be an astronaut. I love the Earth." (6/27/2010)
Patrick, playing his keyboard and singing a song: "Dinosaurs lived before people. They fly and go around" – to the tune of "Can you Feel the Love Tonight." "Dinosaurs, Dinosaurs. There's meat eaters and plant eaters. Then people come." Now I've been invited to do the dinosaur dance. (7/28/2010)
Patrick, on thinking about how we have evolved from fish: "I eat fish, but I don't eat my grandpas." (8/8/2010)
Whilst reading a book about prairie dogs – Michael: "Are you a prairie dog?" Patrick: "No, I'm a human being. [pause] Wait, why are we called human beans?" (8/2010)
Patrick, in the backyard finding bugs to put in his little magnifying container: "Dad, do you want to see the tiniest spider in the WHOLE world?" (11/5/2010)
"Space is up / Earth is down / The sun is hot / Earth is not" (1/24/2011)
Patrick, getting ready for bed: "Let's count sheep. One, two, three" [pause] Me: "How many sheep did you count?" Patrick: "Three, but there was a kangaroo at the end." (1/30/2011)
Patrick, when asked by an OMSI volunteer if he knows what he wants to be when he grows up: "I want to be one of those scientists who goes into nature and looks at stuff and doesn't take it back." (3/15/2011)
When riding the bus home from preschool, Patrick asked me: "Dad, I know that people did not make the planet, the earth. So where did it come from then?" (3/16/2011) Such a big question from a little guy – I did my best!
Patrick, in the backyard looking for bugs and finding a worm: "This worm is AWESOME! I am going to make a good habitat for it." (4/1/2011)
"If you're an elephant, you're an elephant. If you're a Patrick, you're a Patrick. That's being yourself." (7/24/2011)
Patrick, to Catherine, during lunch: "Mom, you speak Spanish and English, [long pause] but do you speak Galapagos Island?" (8/21/2011)
Patrick: "Knock knock." Me: "Who's there?" Patrick: "Pumpkin." Me: "Pumpkin who?" Patrick: "I'm going to carve your face out." (10/20/2011)
Patrick, on being told that he is going to be a big brother: "That's going to be a lot of work for me." (1/3/2012)
Patrick, on being asked what his favorite place in nature is: "I don't have one favorite place, because I love all places in nature. Even the boring places." (6/13/2012)
Patrick has decided we should name the baby based on "where she comes from" or "her features." He says either "Uterus" or "Cutie." Catherine: "Yeah I'm glad our 6 yr old isn't naming our child." (6/15/2012)
Patrick: "Hey Mom, If you're curious we're having the baby tomorrow night." Me: "OK, Nostradamus, pajamas." (7/25/12; due date for our girl is August 11)
Patrick, upon seeing that NASA's Curiosity Mars Rover landed: "But will it work?" (8/5/2012; well, there were pictures [thumbnails!] pretty quickly so I guess it will work!)
Catherine posted on Facebook on 8/12/12: "Love it when my son's sentences start with 'According to my research….'"
Note: Patrick's sister Afton Lee was born on August 15, 2012.
Patrick, to Catherine, in so many words: "Afton and I came from mommy and daddy, and they came from star stuff. Actually, they had extra star stuff and that's how Afton and I were made. There was enough star stuff left over for 100 babies." (August 21, 2012)
"Dad, I love nature. That means I love us, because we are nature." (February 24, 2013)
Patrick, on seeing four young nutria in the water at the Tualatin River National Wildlife Refuge: "So cute, but so invasive!" (July 18, 2013)
We had a close call at Laurelhurst Park. Afton in her stroller almost rolled into the pond. I caught her by quickly throwing my arm out and grabbing the handlebar the last second. Talking to Catherine today about how it scared the shit out of me, and had my heart racing, and Patrick shared: "Yeah, it scared my shit, too!" (August 14, 2013)
4 thoughts on "Patrick Quotes"
Rene'e Crowell on September 29, 2010 at 9:18 PM said:
Michael~these are too precious~mom
Pingback: Monday thought of the week (belated): even the boring places |
Brian Mooney on April 27, 2014 at 11:01 PM said:
Gotta love 'em! (Both the pithy quotes and Patrick!)
bewilderbees on May 11, 2014 at 5:54 AM said:
Kids! Gotta love 'em!


Loving Our Neighbors – The Upward Call Ministries, Inc.
In searching for a home almost two and a half years ago, my wife found a small community of houses in East County San Diego. I passed by this community daily on my way to work not thinking this would be a place we would ever settle down in. The Lord opened doors that allowed us to purchase a home in this area, and since then we have come to love the community we live in.
Over the past few months I started noticing Jehovah's Witnesses setting up brochure stands on the sidewalks around our community. As I drove to work, the grocery store, gas station, post office, etc., I counted a total of four areas Jehovah's Witnesses were consistently setting up stands, all within a mile of our home. Also within that mile, we have one high school, two elementary schools, four bus stops and a community park. Our housing community alone has over 800 homes. As I thought about them in passing, I was struck with how many people potentially the Jehovah's Witnesses had contact with daily.
The Lord began to stir my heart. Do I truly love my neighbor? Am I not only loving my neighbor next door, but am I thinking of the Jehovah's Witnesses in my community as my neighbor too? I felt convicted that I have not been. I should be. All Christians should be. Jehovah's Witnesses are image bearers of God. They're walking in darkness, being deceived and believing in a lie. They need the saving power of the gospel.
After a few weeks of prayer, reading God's Word, and studying the history of the Jehovah's Witness doctrine, I began meeting with them on the street. My first interaction with two younger adults started by immediately addressing their false doctrine. I found myself reading scripture proclaiming the deity of Jesus, addressing the heresy of works based salvation, and so on. The conversation was heightened at times, and after going back and forth with the two Witnesses, I felt frustrated and exhausted. The mutual exchange came to a screeching halt as the couple refused to engage any further. I thanked the couple for their time and left. As I prayed afterward, the Lord reminded me that it is the gospel that saves, (Romans 1:16) not my attempt to defend my faith, or by disprove their doctrine. He reminded me to be more patient, slower to speak.
Early the next morning on my way to work I came across three other Jehovah's Witnesses around the corner from a bus station. I parked close and walked up to their brochure stand just as they were getting out of their truck to pack up. I asked one of them their name and said I would like to speak with them. He told me his name and that he was leaving for work. I asked when he was usually at this spot and he said "5am," I replied back "5am?", "Yes, every day" he said. Wow. Here is someone proclaiming a false gospel to this community, here daily, at 5am. Hours of dedication, all for not. I left for work wondering if indeed he would be there tomorrow at 5am.
My alarm went off just before 5. I spent some time in prayer and the word, leaving for the same location as the day before to see if the Jehovah's Witnesses would indeed be where they said they would be. As I pulled out of the driveway, it was very dark. Just the musky orange glow of the street lights, and a few front porch lights were on around our street. I thought to myself that there was no way they would be out in the dark. As I drove down the street, I noticed the corner where they were located the day before had no street lights, and was barely lit by the lights from across the street. But I could barely make out what seemed to be two small flood lights shining downward. Yep, they had spot lights for their stand.
As I waked up to their truck, an older gentleman got out of the truck and introduced himself. He had a strong accent. I introduced myself and asked about his name and expressed my curiosity of what nationality he was given such a strong accent. He told me he was Jewish. Two others, one whom I spoke with the day before, came out of the truck. They asked me what it was that I wanted.
I began the conversation asking what they were hoping to accomplish out here at so early. The older gentleman began explaining the reason, and started discussing Watchtower doctrine. I felt lead to not interrupt and let him finish speaking knowing exactly where he was going, but giving him my time and my full attention. After he was finished, I thanked him for explaining that to me and asked in return to give me equal amount of time to share the truth of God's word. With the full attention of all three Witnesses, I went through the full message of the gospel. After I was finished with sharing the gospel, we then engaged in further discussion and I had additional time to address many points of contention of their false belief. Looking back at the previous encounter, I spent too much time trying to immediately disprove their beliefs, and walked away without fully sharing the gospel. As vital as it is for us to be equipped and have solid apologetic understanding of our faith (1 Peter 3:15), it is not a substitute for the gospel.
Brothers and sisters in Christ, remember, all those devoting themselves to the Watchtower are on the wide path headed to destruction. If we wait for Jehovah's Witnesses to walk through the doors of our church on their own, we will be waiting, and waiting, and waiting. I know it can be intimidating speaking with cults, and false religions, especially ones that twist scripture, remove scripture, and seek to lead the conversation down seemingly a never ending road. As followers of Jesus Christ, we are filled with the power of the Holy Spirit and suited with the full armor of God.
We, as Christ's church, must step out of the confines of our church doors and take the gospel to the front line. We must bring the good news, the saving gospel, directly to the lost (Isaiah 52:7, Romans 10:13-17).
Pray and ask God to strengthen you. Pray that He fills you with courage and a heart for our Jehovah's Witness neighbors, and the next time you cross paths with them, stop and take the time to share the truth. We are merely messengers, heralds of the gospel. Our duty as Christians is to share the gospel in love, truth, and grace, and let the power of Almighty God to do the rest.
1) First and foremost seek the Lord in prayer, immerse yourself in His Word.
2) Seek the counsel of your local Pastors and Elders to help you prepare.
Good growing response, Don! I have talked to many Jehovah's Witnesses over the years. At one point a couple continued weekly visits to my house for well over a year. Friendly, honest conversation brought joy and life to both of us. These are real people and not robotic members of a cult. Yes, they belong to an organization that has some truly heretical ideas, especially regarding the deity of Christ. And they are our neighbors who want real relationships just like you and I.


Award-winning author, Renea Winchester recently spoke to members of Garden Mania, a part the Enrichment of Life group, which meets at the First United Methodist Church. Winchester spoke about how gardening creates communities. She gave away seeds from Botanical Interests™ (available at Pike's Nursery), liquid fertilizer from Grow Best plant food (available at Home Depot), and tomato plants from Farmer Billy Albertson's garden.
Renea blogs about Billy's farm at Bloggin' Billy's. She is the author of In the Garden with Billy: Lessons about Life, Love & Tomatoes and Stress-Free Marketing: Practical Advice for the Newly Published Author. She is available to speak to book clubs and garden clubs, as well as writing groups.
Contact Renea through her website at reneawinchester.wordpress.com.


Visit our adrenaline pumping, indoor go kart racing attraction and experience some high-octane fun.
We have something for everyone, whether you're a racer, racing fan or spectator. Team building, corporate and social events and kids parties are all catered for. We know what it takes to make your event a roaring success. We have one of the longest (280m), widest and fastest indoor tracks in New Zealand. The main straight is 80m long. Our top end, German engineered, go karts ensure you have the best racing experience ever. You can even try your hand at our indoor paintball and indoor 18 hole mini putt course.
Safety is a top priority at Daytona Raceway Wellington. Our innovative track barrier system absorbs energy on impact meaning a safer track with fewer crashes.
Come and get where the action is at Daytona Raceway Wellington!


A while ago we were sent some sets from Strictly Briks to play with.
The company makes Lego compatible pieces which open up different ways to play with bricks. They specials it base plates and pieces so you can build towers, they also have letters and numbers you can use on the plates as well as a game.
The Brik Trap and Gap set has two large base plates, and 2 stackable base plates plus 15 of the column pieces. They idea is that the trap doors open so that you can push things through (such as cars!).
The Tower set has a whopping 12 base plates and 50 stackers.
These sets are great for anyone who is crazy for Lego and already have a collection. If you like to build towers these are interesting to play with.
A few things to point out about these sets though – on their own, they didn't amuse my kids for long. You do want to have other pieces of lego, esp Lego men and women to play with it (see above!) and cars too. Otherwise you're just building empty towers.
They also can be a little fiddly for younger kids. There's a knack to it as of course the tower gets more fragile the higher up you build it and even my older one got a bit frustrated if the tower came crashing down when adding another layer.
Overall though, these are great. You can get an alphabet set for this (which clicks on) which I definitely have an eye on.
Check out the brand on Amazon.


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Trenčianske Stankovce es un municipio del distrito de Trenčín en la región de Trenčín, Eslovaquia, con una población estimada a final del año 2017 de .

Se encuentra ubicado en el centro-norte de la región, cerca del río Váh (cuenca hidrográfica del Danubio) y de la frontera con la República Checa.

Referencias

Enlaces externos

Distrito de Trenčín

redpajama_set_name: RedPajamaWikipedia


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Self Storage: Everyone Wants a Piece of the Pie
Kris Bennett of Landis shares his thoughts on the future of self storage, as well as tips on how to keep up with this growing sector.
Hilary Daninhirsch
Kris Bennett. Image courtesy of Landis
Kris Bennett earned his real estate license in 2007 with the intention of entering the residential sector. Then, the Great Recession of 2008 happened, which was a less-than-ideal time to be in real estate, to say the least. But after going back to school, Bennett landed an internship with a private equity real estate firm and the world of commercial real estate investment opened before his eyes. As his career grew, Bennett became intrigued by self storage, having pivoted from strictly multifamily investing. He recently left a job with a capital investment firm and entered into a new partnership called Landis, based in Charlotte, N.C., and intends to continue his journey into the self storage world, one facility at a time.
Commercial Property Executive spoke with Bennett about the ins and outs of self storage investing as well as its future outlook.
What are some facts and figures regarding the self storage industry?
Bennett: The U.S. is by far the country that has the most self storage facilities per capita. There is a debate as to what constitutes a self storage facility, but let's say there are 40,000-50,000 facilities that are purely self storage. That is more than all the McDonalds' plus Starbucks' combined square footage. On average, there is seven to eight feet of self storage square footage that exists per person in the U.S.
A lot of self storage is still owned by mom and pop (companies). There is more opportunity here versus multifamily. About 75 percent are owned by the sophisticated investor, while in storage, 25 percent are owned by the sophisticated investor.
The rule of thumb is that about half the tenant base will stay 12 months or more, the other half, about 30-60 days. In that sense, storage is kind of a retail business. People come in and out and you have to have good customer service and treat people well.
Is it easier to develop than multifamily?
Bennett: Yes, it's easier to develop because it's a metal building on a concrete slab. There isn't as much to build compared to a three-story apartment (community) across 10 acres. The developer is more concerned with the width of the drive aisles and if there are enough bollards to protect the buildings than if the clubhouse is painted pretty, the furniture matches, or if the gym has the right equipment. There are some firms that have pivoted from multifamily to self storage. Several cities are pushing back on self storage development by implementing moratoriums. Miami being the latest. It seems we are our own worst enemy.
Is there a region in the country in which self storage is particularly thriving?
Bennett: Texas and Florida are really known for having a lot of self storage, making it a very competitive marketplace. The Southeast in general is where people look to invest. There is a population growth in a lot of Southeastern cities, so you see it popping up more and more in this area. You have friendly business climate for the most part, and the population growth is driving a lot of it as well.
What are some trends that are driving the self storage industry?
Bennett: Storage is driven by change in people's lives. We have a lot of that going on, like someone moves or gets a divorce. For about half the facilities, renters are renting a unit for two months or so, and are doing it because of some change. For example, I talked to a guy a while ago whose father passed away and he can't bring himself to get rid of his father's stuff. The other 50 percent use it long term, like if you have a trade or business, such as keeping medical devices at a facility.
On the investor side, to get into numbers: If I'm renting an apartment for $1000, I might move if there is a $50 raise in rent. If I'm renting a storage unit for $100 and the rent goes up $5, it's not a big deal. There still can be a 5 percent rental increase in both cases, but the tenant base is fairly sticky in self storage because of the hassle to move out, and you can see that rental rate increases don't cause customers to move or get upset for the most part. The sticky tenant base willing to absorb rental rate increases combined with the ease of development compared to multifamily, has lead yield-seeking investors to jump into storage.
It's been said that this is a recession-resistant business, do you agree? Why or why not?
Bennett: I do, looking at history. If you look back in 2008-2009, storage was the only asset classes that showed a positive return, so that is why they called it recession resistant. When the SBA started lending in self-storage via SBA loans around 2010/11, the government began to view self storage as an actual business like they would view any other business, which is really interesting, because there is no asset class in real estate you can do that with. Now, going forward, will that be the case? I don't know because of all the development that is going on.
What are the main challenges in this industry?
Bennett: I think there is always going to be risk of development coming down the road. Too many facilities are competing in the same markets for the same customers. This year and 2021 will be an interesting year for acquisitions professionals because there may be opportunities to purchase facilities that aren't performing. However, because other pros in this industry are saying what I just said, those deals may not trade at a good value. In other words, there is plenty of capital forcing its way into this industry deals that should sell at a discount probably won't because the big groups are chasing the same deals which will continue to push up prices.
On the management front, if you have a competitor opening up down the road, you have to figure out how to manage your facility to retain your tenant base. Those rental rate increases that we talked about earlier may not be so wise to implement. There are third-party management groups that help navigate these waters and they would be worth talking to.
What are the pros and cons of self-storage investing?
Pros: Sticky tenant base, SBA lending options, no eviction hassles, opportunity to acquire from mom-and-pop (but that is getting harder to do).
Cons: Short-term rentals (month-to-month), retail-like with a need for good customer service, pricing is high for acquisitions (harder to find deals that make sense).
What can we expect from the industry going forward in 2020?
Bennett: On the investment side, the storage industry is no longer an investment "secret." In the last few years, more education has hit the market, more operators have jumped in and more small investors want a piece of the pie. I think pricing for facilities will remain high. If a facility is not leasing up well, but it's marketed by a storage broker, that facility will still sell on future potential income (i.e. higher than it should) because there are groups that want in on the action and they think they will be able to fix the problems and lease it up.
No doubt there are smart operators that will be successful at fixing those problems. But a lot of groups should just stay out of storage for now. On the consumer side, the general public knows there are too many facilities because they see it everywhere. People still need it during their personal life changes, or for their businesses. But they might get a better rate for a unit than they could have just a year ago.
#CPETalks
CBRE Global Investors Pays $54M for National Storage Portfolio
Public Storage Expands With $528M Portfolio Acquisition
Top 5 Self Storage Markets for Transaction Activity
Extra Space Storage Adds 37 Properties to Management Portfolio
Blackstone to Pay $1.2B for Simply Self Storage

redpajama_set_name: RedPajamaCommonCrawl


Tuesday's news in less than 2 minutes.
The former Queensland Premier Anna Bligh has given an exclusive interview with Women's Weekly, in which she bares her bald head and talks about her battle with cancer.
The 53-year-old spoke to Channel 9 about her decision to appear in the magazine, and said she thought it was important to highlight for women that if they felt a lump they should call a doctor and do something about it. She also wanted to show what her fight with cancer had really been like.
Back in June, the former Premier announced that she had been diagnosed with non-hodgkin's lymphoma. The diagnosis had been confirmed after a tumour was removed from a lymph node in her neck only a week earlier.
1. The Australian who was killed in a Kenyan shopping mall terrorist attack has been named. Tasmanian Ross Langdon, died alongside his partner Elif Yavuz in the horrific attack. The couple were expecting their first child in two weeks.
Thirty-three-year-old Langdon was an architect, who had designed an AIDS hospital in Kenya on a pro bono basis, and had further helped to develop evo-villages in the area. Ms Yavuz was a malaria specialist working with the Gates Foundation. Kenyan security forces are still fighting the terrorists inside the shopping centre.
2. Gold Coast Suns' captain Gary Ablett Jr has been named as the AFL's best and fairest player, having been awarded the Brownlow Medal at a ceremony at Melbourne's Crown Casino last night.
Also on the agenda at last night's Brownlow Medal was FROCKS. Check out Mamamia's gallery of red carpet arrivals here.
St Kilda's Nick Riewoldt and his wife.
Jarrad McVeigh and his wife Clementine.
Gary Abblett's partner Jordan Papalia.
Brynne Edelsten with husband Geoffrey.
3. New mothers who feel stressed and sad in the early days of parenting are being urged to seek help, after a study of 1000 women revealed that most new mothers tend to suffer in silence. The Bupa Health Foundation report found new mothers were unlikely to seek treatment, even though talking to a specialist could help them cope and to understand that feeling depressed after birth is perfectly natural.
4. Eighty-three-year-old entertainer Rolf Harris appeared in a London court overnight, charged with indecent assault and creating indecent images of children.
Harris' lawyer said his client was likely to plead not guilty to the charges when he appears in front of a higher court early next month. In the meantime, Harris has been granted conditional bail.
5. The principal of an ACT school has come under fire from students and members of the community for sending Australian Christian Lobby campaign material in opposition to gay marriage to parents of students via email.
6. When Australian Financial Review journalist Marcus Priest put questions to billionaire Clive Palmer regarding his $6 billion Waratah coal mine (which is currently seeking Federal environment approval), the journalist probably did not expect the following response.
Priest later clarified on Twitter that the question had been, "whether he would seek approval of project in return for support in Senate". Clive Palmer won the seat of Fairfax this past weekend by 36 votes. Ballots cast in the seat are currently being recounted.
7. Yesterday, a four-year-old child was found in possession of a quantity of methamphetamine, while at a childcare centre in Perth. The staff found the boy playing with a bag of the illegal substance, which a police test confirmed was methamphetamine. The Department of Child Protection and Family Services has released a statement saying that they would interview the parents of the boy.


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Method for the elimination or the enlargement of points of constriction in vessels carrying body fluids
For the provision of an apparatus to lessen or remove points of constriction in vessels of all types whereby ruptures and tears are to be avoided in the vessel walls and, during the treatment of stenosis in blood vessels, the danger of infarction is to be avoided, through use of a treatment catheter (1) that is equipped with two expandable balloons (4, 5) which seal off both sides of a point of constriction (6) in a vessel, whereby the degree of expansion of both balloons (4, 5) can be controlled externally, it is proposed that there be mounted in the wall of the treatment catheter (1) within the region confined by the balloons (4, 5) an inlet piece (A) for the supply of media capable of dissolving or crumbling into smaller particles the material (7) at the point of constriction and an outlet piece (B) for the removal of the material (7) dissolved or crumbled at the point of constriction, whereby these pieces are connected with an externally accessible conduit (10, 11) (FIG. 1).
Weikl, Andreas (Erlangen, DE)
Merkel, Volkmar (Erlangen, DE)
Schneider Medintag AG (Zurich, CH)
604/101.05, 604/919
A61M25/00; A61B17/22; A61F2/958; A61M1/00; A61B; A61M; (IPC1-7): A61M25/00
128/328, 128/344, 128/348.1, 604/101, 604/102, 604/53, 604/49-52, 604/54, 604/28, 604/265, 604/266, 604/269
4430083 Infusion catheter 1984-02-07 Ganz et al. 604/265
4271839 Dilation catheter method and apparatus 1981-06-09 Fogarty et al. 128/344
4224929 Endoscope with expansible cuff member and operation section 1980-09-30 Furihata 128/6
2687131 Female incontinence catheter 1954-08-24 Raiche 128/349
DE1069823B November, 1959
DE2816391A1 1978-11-02
FR1460776A 1966-01-07 128/328
FR2350849A1 1977-12-09
THALER, MICHAEL H
WILLIAM H. LOGSDON (WEBB, BURDEN, ROBINSON & WEBB 515 OLIVER BLDG., PITTSBURGH, PA, 152222363, US)
1. A method of treating stenosis by eliminating or expanding the points of constriction which are customarily formed of a sponge-like calcified and fatty tissue in blood carrying vessels of the body through use of a flexible treatment catheter having separate support conduits formed by longitudinal partition walls and at whose end two balloons are situated, said method comprising the steps of sealing off the section of the blood vessel containing the stenosis with the two balloons, introducing a solvent of predetermined concentration and duration of effect to act upon the stenosis through a first support conduit in the catheter such that the tissue of the stenosis is dissolved, softened, or crumbled into smaller particles, and draining the particles from the sealed section of the blood vessel through a second separate support conduit.
2. The method defined in claim 1, and including maintaining the circulation of blood contained in the blood-carrying vessels to the downstream organs by a further separate support conduit in the catheter.
3. The method defined in claim 1, wherein the solvent, as determined by its type, concentration, and duration of effect, acts upon the stenosis only to soften the tissue to permit it to be removed as a whole by the treatment catheter when the treatment catheter is withdrawn from the vessel.
4. The method defined in claim 1, wherein the solvent, as determined by its type, concentration, and duration of effect, acts upon the stenosis to such an extent that the tissue of the stenosis is crumbled into smaller particles which are removed through the second separate draining support conduit of the treatment catheter.
5. The method defined in claim 1, wherein the solvents are selected from the group consisting of enzymes, acids and alkaline solutions.
6. The method defined in claim 5, wherein the acid is a nitrous acid.
7. The method defined in claim 5, wherein the alkaline solution is caustic soda.
8. The method defined in claim 1, characterized in that the duration of effect of the solvent on the stenosis is limited to a predetermined time interval by inhibitors.
9. The method defined in claim 1, and including a circulating rinse for the removal of the tissue at the point of constriction which has been dissolved, softened or crumbled into smaller particles.
10. The method defined in claim 9, characterized in that the double-balloon catheter is used for performing the circulating rinse process.
The invention relates to an apparatus and method for the elimination or the enlargement of points of constriction in vessels carrying body fluids.
An apparatus of this art known from DE-AS No. 10 69 823 has as least two expandable balloons arranged one behind the other and separated by a given distance from each other on the vascular end of a treatment catheter. Each balloon is connected with an externally accessible conduit and can be inflated separately be external pressure. After insertion of the treatment catheter into a ureter, the ureter can be distended by inflating the balloons. A concretion which gives rise to a point of constriction or which can block the ureter can be confined between the balloons. While the balloons are in expanded condition the treatment catheter can be withdrawn from the ureter and thus remove the concretion. However, such a process can lead to complications when the concretion, for example, becomes wedged during withdrawal between a balloon and the inner wall of the ureter. By changing the expansion of the balloons the concretion must be correctly reconfined within the region bounded by the balloons. Upon such withdrawal the entire ureter from the narrow point on is subjected to a pronounced distention and the inner wall is especially stressed by the strong frictional pressure. Thus the pressure can result in tearing and separation of at least the inner wall of the ureter.
Furthermore, it is already understood from DE-OS No. 30 28 089 for the enlargement of points of constriction in the arterial system to use a treatment catheter on the end of which is fixed a balloon whose circumference can be expanded by a determined amount. This balloon is situated in the region of the point of constriction and is filled by a catheter with fluid such that the tissue in the blood vessel wall which is causing the point of constriction is compressed and remains in that condition. In the course of this procedure there are not many means for avoiding tearing the intima--the innermost wall of the vascular system--during the dilation. Moreover, there exists the danger that the interior vascular layers will be partially separated and cover the open interior space of the blood vessel which can lead to obstructions in the vascular system and/or reduced blood flow to those organs which are supplied by the afflicted blood vessel. Thus, for example, insufficient blood supply to the coronary arteries can give rise to an infarct.
The requirements to be met by the present invention consist of the provision of a reliable, economically producible apparatus of simple design with the aid of which the points of constriction of vessels that carry any given body fluid, irrespective of their spatial arrangement or extension in the vascular system, are reduced or eliminated to such an extent that no collapses or tears in the vascular walls can occur. Upon application in the blood vessels of an apparatus in accordance with the invention, provision of the organ or organs located behind the point of constriction is assured even during a longer treatment period for the point of constriction, and consequently even in these cases the danger of infarction is precluded.
These requirements are met in accordance with the invention.
By establishing a gap between the two balloons and its connection to an externally accessible conduit, any point of constriction can be gently removed in a relatively short time by targeted dissolution or crumbling of material at the point of constriction. In this procedure virtually no unfavorable side effects occur as a result of the distension of the vessel since this distension is undertaken in a healthy region of the vessel and only at two closely bounded points. The apparatus in accordance with the invention can therefore be used in all of those cases where the point of constriction is formed by substances that can be dissolved and/or crumbled into smaller pieces.
By softening the material at the point of constriction, the removal of same from the vicinity of the point of constriction is particularly unproblematic since the danger of damaging the vessel walls is totally precluded in this case due to the consistency of the material at the point of constriction.
As a result of a favorable configuration of the invention, a supply conduit can also be provided through which sufficient support for the organ located behind the treatment area can be assured simultaneously with treatment of the point of constriction. It is especially advantageous that, by use of this invention within predictable regions of vessels carrying body fluids, treatment fluids in a definable range, even in rather strongly concentrated form, can be brought to act upon material at the point of constriction for quite arbitrarily selectable time intervals.
Favorable configurations of the invention are the subject of the subordinate claims.
There follows a more detailed explanation of the invention by way of illustrative examples which are presented in the drawing in greatly expanded scale. There is shown:
FIG. 1 In longitudinal cross-section, a blood vessel with inserted guidance and treatment catheters as well as confinement balloons situated on both sides of the point of contracted passage,
FIG. 2 a cross-section as defined by the intersecting line II--II of FIG. 1,
FIG. 3 a longitudinal section of the treatment catheter with a movable balloon mounted on it,
FIG. 4 a cross-section as defined by the intersecting line IV--IV FIG. 3,
FIG. 5 a view of a treatment catheter with retracted partitions for the formation of conduits to feed and to drain liquids or gases,
FIG. 6 A longitudinal section of a part of a treatment catheter with partially perforated lateral surfaces or predetermined points of rupture, as defined by the intersecting line VI--VI of FIG. 5,
FIG. 7 a longitudinal view of a section of a vessel with inserted treatment and guidance catheters and with a conduit, which provides support and simultaneously supplies the balloon with pressure, in the treatment catheter,
FIG. 8 a cross-section as defined by the intersecting line VIII--VIII of FIG. 7,
FIG. 9 a longitudinal view of a section of a blood vessel with inserted treatment catheter upon which is mounted a movable catheter used for confining the region in question,
FIG. 10 a cross-section as defined by the intersecting line X--X of FIG. 9 and
FIG. 11 a cross-section corresponding to an intersection line X--X of FIG. 9, but with a treatment catheter with only one longitudinal partition, as is shown in FIGS. 7 and 8.
The treatment catheter 1 is inserted by a guidance catheter 2 into a blood vessel 3. It extends beyond the guidance catheter 2 so far that the balloons 4 and 5 positioned on the treatment catheter 1, along with the point of constriction 6 or stenosis which is confined between them, lies in front of the end of the guidance catheter 2. The point of constriction 6 is usually formed from a spongy, fatty, calcium-rich tissue 7 which is indicated by cross-hatching in the drawing. In cases where the tissue 7 completely or almost completely closes off the blood flow of the blood vessel 3, the treatment catheter 1 or tentatively another instrument is pushed through the latter. Otherwise, the treatment catheter 1 is brought far enough through the remaining opening at the point of constriction 6 that the balloon 4 in its inflated condition 4' seals off the point of constriction 6 to the rear and the balloon 5 in its inflated condition 5' seals off the point of constriction 6 to the front side, i.e. that the blood vessel 3 is totally closed off on both sides of the point of constriction 6.
The expansion or inflation of the balloons 4, 5 can be accomplished by a gas or liquid medium. The letter can be let in or out across the inlet/outlet nozzle 8 or 9 through an externally connected, pressurized conduit, by which means the quantity and pressure can be regulated. In order to assure during the treatment of points of constriction 6 in blood vessels the support of the organ or organs behind the point of constriction 6 despite the seals at both sides of the latter, especially in cases of rather long operating times, an additional support conduit 11 is provided which represents a type of "bypass line" to the sealed off area around the point of constriction. The support conduit 11 is preferably arranged coaxially with the treatment catheter 1. It can, however, in deviating from the described manner, also be installed or connected in another position and/or in the form of a rather large number of conduits. Through this support conduit 11 blood and/or another liquid can be introduced in front of the blockage from the outside, preferentially under positive pressure, or from the blood steam with the help of an overflow conduit. These means provide sufficient operating times without giving rise to a danger of infarction.
In order that only the fatty, calcium-rich tissue 7 of the point of constriction 6 is affected and not the inner layers of the blood vessel 3, a chemical medium in the form of a solution, which is capable of dissolving the tissue 7, is pumped through the supply conduit 12 with the inlet piece A into the space containing the tissue 7 of the point of constriction. For this purpose digestive enzymes and similar substances are suitable, among other possibilities.
For other applications, such as the treatment of gall or kidney concretions, still other substances such as solvent acids can be considered.
For the removal of dissolved or crumbled particles and for reducing the treatment time, it is advantageous to have a continuous, circulating rinse process which is assured by a return conduit 13 with the outlet piece B. In principle, however, it is also possible to return through a single conduit the medium which dissolves or crumbles the tissue 7 at the point of constriction and alternately to drain the dissolved or crumbled tissue 7 at the point of constriction through the same conduit. Such a development is shown in FIGS. 7, 8 and 11 which are to be explained in greater detail later. It is evident that the feed conduit 12 can also be used a a return conduit, and that the return conduit 13 can also be used as a feed conduit. The number of feed and return conduits can also always be increased according to need. The same number of inlet/outlet nozzles 8, 9 or openings in the treatment catheter 1 may be chosen as there are inlet and runback channels so that an opening can be assigned to each channel.
In order to be able to accommodate the extent of the blockage as determined by the extension of the tissue 7, it is advantageous not to mount the balloon 5 rigidly--as shown in FIG. 1--but rather movably on the treatment catheter 1. One such design is represented in FIGS. 3 and 4. The balloon is thereby fixed to a sliding member 14 which can be moved from the outside back and forth, preferably with the aid of a rather stiff strand 15 of synthetic fiber--preferentially of Perlon or equal. The artificial fiber strand 15 can thereby pass through a conduit 16 which is incorporated, for example, in the elongated projection 17, of the treatment catheter 1 that also serves simultaneously to guide the sliding member 14, and which thus is practically incorporated into the reinforcement of the wall of the projection. Simultaneously, the inflation medium can be introduced and removed through this conduit 16 and its pressure can be regulated externally.
In order that the gap between sliding member 14 and the outer wall of the treatment catheter 1 can be faultlessly sealed, there is provided, at least on the side facing the point of constriction 6, a sealing sleeve 18 which additionally contributes to effective sealing at this point because of its particular shape. The orifice, through which the gaseous or liquid expansion medium is supplied or removed for the expansion of the now movable balloon 5, is identified as 19.
Instead of tubular conduits 10, 12, 13 which are positioned and mounted on the wall sections of the treatment catheter 1, the inner cavity of the treatment catheter 1 can also be accordingly subdivided by longitudinal partitions 20 (FIGS. 2 and 5) such that chambers 21 are established through which, depending upon the requirements, the corresponding medium can be fed.
Furthermore, in many cases--especially when using longitudinal partitions 20--instead of mounting inlet/outlet orifices 8 and 9 or orifices A and B at the ends of the conduits 12 and 13, it can be advantageous at these points to provide the walls of the treatment catheter 1 with perforations 23 so that the latter appear, as can be seen in FIGS. 5 and 6, only after breaking the predetermined points of rupture 22, thus allowing the length of the perforated section of the catheter to be adjusted, just before the operation, in accordance with the size of the region of constriction which is to be treated.
FIGS. 7 and 8 present a further illustrative example in accordance with the invention with a single longitudinal partition 20. The treatment catheter 1 is thereby divided into two conduits of which the one is configured as a combined pressure and support conduit 24 and the other as a combined feed and drain conduit 25 for the point of constriction 6. The one conduit 24 has an orifice 8 or 9 in the region of each balloon 4, 5 and an outlet orifice 27 on the vascular end 26 of the treatment catheter 1. The other conduit 25 has an inlet/outlet orifice A/B in the region of confinement. Through use of this treatment catheter 1, whose potentially small diameter is especially well suited for vessels with small cross-sections, it is possible to expand simultaneously the balloons 4, 5 by means of the fluid pressure generated in conduit 24 by an externally supplied fluid, in particular, a support fluid for organs located downstream--e.g., blood--and consequently to seal on both sides the confined region around the point of constriction 6. The fluid is then discharged under pressure through the outlet orifice 27. On the other hand, the substance for dissolving the material at the point of constriction, or another type of substance, can be continuously or periodically pumped through the other conduit 25 into the point of constricted passage 6 and subsequently the dissolved material can be drained from the point of constriction along with the remaining substance. Thus the process provides the desired effect through use of an easily manufactured treatment catheter 1, while maintaining a very small diameter of this catheter.
In accordance with a further, advantageous development of the invention, either balloon 4 or 5 can be equipped in this configuration with a covering or wall which is more elastic than that of the other balloon. In the example shown in FIGS. 7 and 8, this balloon is 4. It is thus possible to establish and regulate the pressure such that both balloons 4 and 5 do seal and, for example, balloon 4 continues to seal during withdrawal of the substances from the confined region but balloon 5 does not (see FIG. 7). Hereby, it is possible to use in addition the guidance catheter 2 for rinsing or draining since, with such a pressure setting, the point of constriction 6 is also externally accessible from the side of the guidance catheter 2.
For practical considerations the balloons 4, 5 of the apparatus in accordance with the invention can be configured such that they assume a definite form and size and then do not expand further, even upon application of considerably higher pressure.
In the advantageous configurations of the object of the invention which are shown in FIGS. 9, 10 and 11, the balloon 5, which is rather far from the vascular end 26 of the treatment catheter 1, is situated on or at the end of a region-confining, or confinement, catheter 28 which is mounted on the treatment catheter 1 by a sliding attachment. The confinement catheter 28 is equipped with a pressure conduit 29 which preferably is integrated into the wall of the confinement catheter 28, the length of the confined region can be chosen according to requirements and can be sealed off or opened by means of the separate expansion capability of the balloon 5. Here again a space can advantageously be retained between the treatment catheter 1 and the confinement catheter 28, and the latter can be used for rinsing or removing fluid. For a very compact design, one or more indentations 31 can be provided on the inner wall of the confinement catheter 28 and/or indentations 32 on the outer wall of the treatment catheter 1, as shown in FIGS. 10 and 11. In order to subsequently achieve greater flow cross-sections, the indentations 31 of the confinement catheter 28 can be positioned opposite the indentations 32 of the treatment catheter 1. Even with this design solution, a single longitudinal partition--as shown in FIG. 11--can be provided in the treatment catheter 1, and the treatment catheter 1 can include orifices, as demonstrated by FIG. 7, so that it is additionally possible to attain the beneficial effects indicated there. Furthermore, the apparatuses as shown in FIGS. 9, 10 and 11 can include a guidance catheter 2 which is not illustrated.
The catheter for the treatment of points of constriction, in accordance with the invention, can be used with all types of vessels carrying body fluids, thus with all types of blood vessels or other fluid-bearing vessels, such as conduits carrying medicinal liquids, or also with larger lymphatic vessels.
Further areas of application--besides the primary area of treating points of constriction in blood vessels--are, for example, the treatment of constrictions in the bile duct, in the outlet duct of the pancreas, or in the spinal canal.
It is also possible with the invention to feed chemical substances in high or rather high concentrations to regions of vessels for the purpose of stimulating capillary branching from these vascular regions outwards. Of special interest in this regard are the materials described by Dr. Josef Wissler, Max-Planck-Institut, Bad Nauheim, for the stimulation of vascular branching, angiotropines by name, which are isolated from white blood corpuscles.
The treatment of points of constriction with the catheter in accordance with the invention can be undertaken in several steps and, if necessary, with the use of various treatment media and/or various concentrations of the treatment media.
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Lysergic acid diethylamide (LSD), also known as 'acid', is the most potent man-made hallucinogenic drug. Just 1/250 millionth of a gram can cause altered perceptions of reality.
Users generally take LSD orally, but they also can smoke, inject or inhale it through the nose. The normal dose is about one millionth of a gram. Because the dose size is so tiny, LSD is measured into or onto other substances (such as sugar cubes or pieces of paper) so that the user can find and ingest it.
When the drug is taken orally, the initial effects begin within 30 minutes. The user experiences the maximum effects in about an hour. The psychological, perceptual and behavioural effects of LSD last eight to 12 hours, then slowly wear off. The body rids itself of LSD with 24 hours.
LSD is not physically addictive. However, this powerful drug can be habit forming and may create psychological dependence when taken frequently or in large doses.
LSD does not actually occur naturally, and there appears to be quite a lot of confusion on this point. Lysergic acid is different to Lysergic acid amides, which occur naturally. To get technical, an amide is a compound that is usually formed from a carboxylic acid (which LSD is) and an amine (in this case diethylamine).
Morning glory seeds (less potent).
For the record magic mushrooms do not contain lysergic acid at all, but rather contain the psychedelic substance psilocybin.
Because LSD grossly impairs judgment, on occasion users have injured or killed themselves by jumping out of windows, throwing themselves in front of moving cars, swimming out to sea, trying to run through walls and other dangerous acts.
Bad trips are LSD experiences during which users feel they have lost control of their thoughts, perceptions and behaviours. This frightening mental state may cause panic reactions, confusion and mental depression. Bad trips can happen to anyone, but occur most often in first-time LSD users and individuals with psychiatric problems.
What determines a user's reaction to LSD?
There is no sure way to know who will experience a bad LSD trip. LSD tends to intensify the user's natural personality traits.
Flashbacks are spontaneous recurrences of an LSD experience that tend to have all the qualities of the original trip. They may happen after a single dose, but are more common among frequent LSD abusers.
Flashbacks can occur days or even weeks after using LSD. I have had clients who had radically 'bad trips' and then experienced flashbacks, nightmares and re-experiencing of the trip up to a month later. Flashbacks may last a few minutes or several hours, and can happen several times a day, once a week, once a month or only once. Certain experiences also can trigger flashbacks, including stress, bright flashing lights and use of other drugs.
Perceptual flashbacks: The user experiences the perceptual distortions of vision, hearing, smell, taste and touch that occurred in the original LSD trip.
Emotional flashbacks: The user relives strong feelings of panic, fear and loneliness similar to those experienced during a bad LSD trip.
Somatic flashbacks: The user feels altered body sensations similar to those experienced during a bad LSD trip.


text:
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text:
Q: How do neural networks handle noise in activations? If the activations of different layers of a neural network are perturbed, will the network be able to recover from that and do the correct prediction?
Is there a training method that makes neural networks resilient to noise?

A:
If the activations of different layers of a neural network are perturbed, will the network be able to recover from that and do the correct prediction?

That depends on the amount of noise, and if the network was trained with this noise. If you train network without any noise, it won't be able to handle it later. Also, if the noise is too strong, the network will probably give you bad results.

Is there a training method that makes neural networks resilient to noise?

There are plenty. Take dropout for example: Dropout trained networks are by default made resilient to multiplicative binary noise. Another example are noisy autoencoders [1].

[1]: Poole B. et al., 2014: Analyzing noise in autoencoders and deep networks.

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text:
Dr Tapas Sen
Reader in Nanomaterials Chemistry
Tapas is currently a "Reader in Nanomaterials Chemistry" and leading the Nano-biomaterials Research group at UCLan. He is fully associated with three Research Centres at UCLan. He is passionate about teaching materials chemistry with physical aspects and doing cutting edge research on Nano/ Nano-biomaterials Chemistry. He has supervised several PhDs, MPhil, MSc and BSc Chemistry students and established a track record by publishing high quality research papers in collaboration with academic and industrial organisations across the Globe.
Tapas is responsible for several levels 6 and 7 modules as a module leader. More specifically he is the module leader of the dissertation research projects of BSc Hons in Chemistry and MSc in Synthetic Organic Chemistry. He is leading the Nano-biomaterials Research Group (www.senlabs.org) within the area of Materials Science and is a member of the Functional Materials Research Group. He is fully associated with three UCLan's Research Centres such as (i) Centre for Smart Materials; (ii) Centre for Drug Design & Development and (iii) Centre for Brain Barrier He is a Fellow of the Royal Society of Chemistry (FRSC) and Higher Education Academy (FHEA) in UK. He has a foundation degree in project management (PRINCE II) endorsed by the UK government as the project management standard for public projects. He has a worldwide network and successfully chaired one International Symposium "Functional Nanomaterials in Industrial Applications: Academic – Industry Meet" (www.nanosymposiumatuclan.net) at the University of Central Lancashire, Preston in 2016, and several International workshops at UCLan campus. He is now the convenor of 1st Virtual International symposium (www.secondnanosymposiumatuclan.net) in July 2020. He is also the creator of Society for Functional Nanomaterials at UCLan in collaboration with industries.
After completing his PhD in India, Tapas has been outside India since 1997. He worked in Weizmann Institute of Science, Israel from 1997 to 1999 in the world leading Solid state NMR group as a post-doctoral visiting scientist. He then moved to UK in February 2000 and worked as a postdoctoral Research Fellow in the University of Manchester Institute of Science and Technology (UMIST), Manchester (2000-2003) on an industrial project funded by ICI Synetix. He later worked on multimillion Euro projects under EU framework V and VI programmes (2003-2008) in Italy under Greenwich University, Kent University in UK before joining as a lecturer in Chemistry at the University of Central Lancashire in 2008. He was promoted to senior lecture in 2010 followed by Reader in Nanomaterials Chemistry in 2015. He was the course leader for two MSc in Chemistry courses and MSc in Forensic Toxicology from 2013 to 2019. He was instrumental in successful accreditation of Forensic Toxicology course as a course leader and an active contributor of Undergraduate Chemistry both BSc Hons and MChem courses. His main research area is Nano/ Nano-biomaterials in chemical and bio-chemical applications.
(www.senlabs.org)
BSc. Hons in Chemistry 1989
MSc in Physical Chemistry 1991
PhD in Materials Chemistry, 1997
National Chemical Laboratory, Pune, India
PGCHE, Kent University, UK 2009
Hind Rattan Award (Indian Jewel) by NRI society, Bangkok, Thailand, January 2018
Livesey Award (Sabbatical scheme) 2011-12
ICI-Synetix Patent Quiz award during the 11th ISCT meeting, Sunderland Marriott Hotel, Seaburn, Nr Sunderland, UK, May 2001
Feinberg Visiting Fellowship at Weizmann Institute of Science, Nov'97 to Nov'99
Fellowship granted by University Grant Commission of India after qualifying the National Eligibility Test (NET) 1992-1997
National (Indian) scholarship during M.Sc studies for securing 3rd position in the University (First 3 students were awarded) 1988-1991
Nano-water
Nano-catalysis
Nano-biosensor
Fellow of the Royal Society of Chemistry (FRSC)
Fellow of the Higher Education Academy in UK (FHEA)
Editorial board members of several international peer-review high impact journals such as Nature Scientific Reports, Biomedicine, International Journal of Nanomaterials, Nanotechnology and Nanomedicine, Journal of Nanoparticles, International Scholarly Research Notices and Advances in Nanomedicine and Nanotechnology Research
Tapas is leading the Nano-biomaterials Research group at the University of Central Lancashire founded in 2008 when he moved from the University of Kent, Canterbury, UK. The group is dedicated in researching nano / nano-biomaterials and their applications in separation science, nanomedicine, industrial catalysis and bio-sensors. More information can be found in group's website here
Nano-biomaterials Research Group
Design and development of highly efficient route for the deep photocatalytic decontamination of waste water with heavy metal ions and recalcitrant organics (Jan'18 to Dec'20): Project funded by Shanghai Government, China in collaboration with East China University of Science & Technology, China
Multifunctional Nanoparticles in Cancer Therapy (June 2017 to May 2020): Project funded by UK-India Education and Research Initiative (UKIERI) and Department of Science and Technology (DST), India in collaboration with Indian partners (Delhi University and VP Chest Institute, New Delhi, India) with UK industrial partner (Hosokawa Micron Ltd. UK).
Magnetic hyperthermia based drug delivery (Dec'13 to Nov'18): Project funded by Royal Society, UK and Nanoscale Biomagnetics SL, Spain to study magnetic hyperthermia for bio- catalysis and drug delivery
Multifunctional hybrid nanocomposites for the separation of toxic and microbial contaminants from water (Aug'14 to Dec'16): Project funded by UK-India Education and Research Initiative (UKIERI) and Department of Science and Technology (DST), India in collaboration with Indian partners (Tata Chemicals Ltd. and Indian Association for the Cultivation of Science) with UK industrial partner (Feedwater Ltd.)
Removal of toxic and valuable metal ions from soil and water contaminated with battery wastes (Sept'13 to Dec'16): One PhD thesis (Amritvir Kaur, University of California, Merced, USA) has been completed.
Multifunctional Nanocomposites for the Separation of Pollutants from Industrial and Municipal Sewage Water (Dec'11-Dec'14)
Collaborators: Prof Dongyuan Zhao (Editor, J. Mat. Chem. RSC), Fudan University China and Mr Gary Hogben (Technical Manager) Feedwater Ltd. UK, Prof. Glyn Morton, Dr Tim Mercer, Dr Justin Whitty from UCLan
Immobilisation of biomolecules on magnetisable solid supports for applications in bio-catalysis and biosensors (Oct'10 to Sept'13): One PhD has successfully completed in Dec'13. Collaborator: Dr Boris Oberheitmann (CEO), Q-Bioanalytic, GmbH, Germany
Identification of monolayer and multilayers patterned organic groups and single stranded DNA primers on flat and particulate materials by Atomic Force Microscope (Feb'13 to Dec'13): A postdoctoral fellow (Dr Erdal Sonmez) from Ataturk University, Turkey completed successfully and initiated a new project
Enzyme immobilised hierarchically ordered porous silica for chiral catalysis (2011-2012) Royal Society of Chemistry small research grant
Transition metal containing hierarchically ordered porous materials for oxidation catalysis (2010-2012) under summer internship and UG project scheme
Immobilisation of enzyme in hierarchically ordered porous solid (2010-11) ) Royal society of Chemistry small research grant
Core-shell bio-compatible superparamagnetic iron oxide nanoparticles (SPIONs) for drug delivery (2009-2011) Collaborators: Dr Abdelbary Elhissi, Dr Tim Mercer at UCLan and Dr Morteza Mahmoudi, Pasteur Institute, Iran
Development of biocompatible fluorescence nanoparticles (2009), Nuffield Foundation, UK, As a collaborator
Surface Patterning of Nanoparticles in Suspension (2009-2011) EU Framework VI grant, completed as a collaborator
Collaborator: Prof Ian James Bruce, Emeritus professor of University of Kent, Canterbury, UK
One month distinguish collaborative Programme £1500-2019
URIS Summer Internship: 8 weeks fully paid £200/week (total £1600)-2019
2 years collaborative project (Jan'18-Jan'20) funded by Shanghai Government, China in collaboration with East China University of Science & Technology, Shanghai, China, Total value: 0.5M CHN (£50K)-2018
UCLan summer internship £2K-2017
3 years collaborative project funded by UK-India Education and Research Initiative (UKIERI) and University Grant Commission (UGC), India in collaboration with Delhi University, VP Chest Institute, India and Hosokawa Micron Ltd., UK: Total value £215477-2017
UKIERI for dissemination activity £11495-2016
£15970 from 1st International Symposium-2016
School of Forensic and Investigative strategic research fund 2014-15: £8.5k
2 years collaborative research project with Peking University China, funded by Shenzhen Government, China: Total value RMB 800K (£80K)=2014
2 years collaborative project funded by UK-India Education and Research Initiative (UKIERI) and Department of Science and Technology (DST), India in collaboration with Tata Chemicals Ltd. India and Indian Association for the Cultivation of Science, India along with Feedwater Ltd. UK: Total value £144K-2014
RSC instrument grant for magnetic hyperthermia, £14.96K as a part of a larger project (£55k)-2013
School of Forensic and Investigative strategic research fund for REF 2014: £4.5k-2013
UCLan Summer Intern scheme: £2K
Royal Society of Chemistry small research grant: £1.94K (05th December 2011)
Q-Bioanalytic, Germany, Partial PhD studentship: £15K (2011-2013) Date of award Sept'11
UCLan China Collaborative Research Grant £108.3K (2011-2014) funded by UBTSL, Shenzhen and Fudan University
Royal Society of Chemistry small research grant : £2K (date of award 12th December 2010)
International Studentship Grant for PhD: £15K (2011-2014)
EU Framework VI (subcontractor): £20K (date of award November 2009)
UCLan research equipment (RED) funding to buy mercury porosimeter: £55K
UCLan summer Internship: £3K
UCLan travel bursary scheme: £0.5K
UCLan Summer internship: £2.5K
Nuffield Foundation: £1.2K (June'09)
Arnoux PhD bursary scheme: £12.5K
Global Challenge Research Fund via Royal Society, UK in collaboration with Kumayun University, India, India (Total value £168K)
UKIERI project with Central Glass & Ceramic Research Institute, Khurja, India on Waste Management (Prof Karl Williams as PI and Dr Tapas Sen as Co-I from UCLan): Total value £120K
First International Virtual Symposium: Second International Symposium "Functional Nanomaterials in Industrial & Clinical Applications: Academy-Industry-Clinicians Meet" July 2020
First International Symposium "Functional Nanomaterials in Industrial Applications: Academy-Industry Meet" April 2016
First International workshop on Magnetic Nanoparticles, August 2016
Telephone:+44(0)1772894371
Email:tsen@uclan.ac.uk


prev: BOF #5: BPI: What's your Business Programming Interface?
We're pleased to have John Coggeshall (and spring) return to NYPHP for our April meeting. Long-time web expert, John will show his latest techniques for rolling out and managing web applications.
One of the most undiscussed subjects in web application development today is application deployment. In this talk, we'll discuss how to use a great deployment tool Puppet to not only deploy your application into staging or production, but how that exact same work can be used to build robust development environments quickly and easily that are entirely consistent with their staging and production counterparts. In this talk you'll learn actionable techniques, tips and tricks to take your deployments and development environments from self-created hacks to robust maintainable processes.
John Coggeshall is CTO of Individual Digital, Inc., an advertising market platform designed to connect consumers and advertisers directly together. A former senior member of Zend Technologies' Global Services team, he got started with PHP in 1997 and is the author of four published books and over 100 articles on PHP technologies with some of the biggest names in the industry such as Sams Publishing, Apress and O'Reilly. John also is a active contributor to the PHP core as the author of the tidy extension, a member of the Zend Education Advisory Board, and frequent speaker at PHP-related conferences worldwide. His web site, http://www.coggeshall.org/ is an excellent resource for any PHP developer and you can follow him on twitter by adding @coogle.


text:
Il singolare maschile del torneo di tennis Prague Open 2005, facente parte dell'ATP Challenger Series, ha avuto come vincitore Jan Hernych che ha battuto in finale Jiří Vaněk 3-6, 6-4, 6-3.

Teste di serie

 Tomáš Zíb (secondo turno)
 Jan Hernych (Campione)
 Peter Wessels (primo turno)
 Gaël Monfils (quarti di finale)

 Raemon Sluiter (primo turno)
 Marcos Baghdatis (primo turno)
 Jiří Vaněk (finale)
 Michal Tabara (secondo turno)

Tabellone

Finale

Parte alta

Parte bassa

Collegamenti esterni

Prague Open 2005


text:
Vettel fastest in final Italian GP practice
September 01 2018 02:54 PM
Hamilton on pole after rain shakes up Belgian grid
Ferrari Mercedes Formula One Lewis Hamilton Sebastian Vettel Italian Grand Prix
Ferrari's German driver Sebastian Vettel drives during the third practice session in Monza on Saturday ahead of the Italian Formula One Grand Prix.
Reuters/Monza, Italy
Sebastian Vettel was fastest in final practice for the Italian Grand Prix on Saturday but Mercedes's Formula One leader Lewis Hamilton closed the gap and split the two Ferraris on the timesheets.
Vettel lapped with a best time of one minute 20.509 seconds, 0.081 quicker than Hamilton, with the sun coming out after morning rain at Monza.
The German did his run earlier in the session than Hamilton.
Ferrari's Kimi Raikkonen was third fastest, 0.173 off the pace, with Valtteri Bottas fourth for Mercedes ahead of what is likely to be a battle between the two front-running teams for pole position.
Red Bull's Max Verstappen was fifth fastest.
Hamilton, 17 points clear of Vettel with eight races remaining, has been on pole at Monza for the past four years while Mercedes are unbeaten there in the V6 turbo hybrid era that started in 2014.
However Ferrari's hopes of a first home win since 2010 are high after Vettel triumphed in Belgium last weekend with a car that clearly had the measure of the Mercedes.
He was also fastest on Friday at Monza in a one-two with Raikkonen.
Both Hamilton and Vettel have five wins each in a season likely to see one of them crowned as a five-times world champion.
Sauber's Swedish driver Marcus Ericsson returned to action after a huge crash on Friday that had his mechanics breaking the overnight curfew to get the car rebuilt in time.
Ericsson is likely to have to take a grid penalty as a result of engine changes made.


text:
Contact mechanics of polyolefins: effect of pre-stretch on the frictional response and the onset of wear
S.F.S.P. Looijmans, P.D. Anderson, L.C.A. van Breemen
Research output: Contribution to conference › Poster › Academic
Looijmans, S. F. S. P., Anderson, P. D., & van Breemen, L. C. A. (2018). Contact mechanics of polyolefins: effect of pre-stretch on the frictional response and the onset of wear.
Looijmans, S.F.S.P. ; Anderson, P.D. ; van Breemen, L.C.A./ Contact mechanics of polyolefins : effect of pre-stretch on the frictional response and the onset of wear.
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title = "Contact mechanics of polyolefins: effect of pre-stretch on the frictional response and the onset of wear",
author = "S.F.S.P. Looijmans and P.D. Anderson and {van Breemen}, L.C.A.",
Looijmans, SFSP, Anderson, PD & van Breemen, LCA 2018, 'Contact mechanics of polyolefins: effect of pre-stretch on the frictional response and the onset of wear'.
Contact mechanics of polyolefins : effect of pre-stretch on the frictional response and the onset of wear. / Looijmans, S.F.S.P.; Anderson, P.D.; van Breemen, L.C.A.
T1 - Contact mechanics of polyolefins
T2 - effect of pre-stretch on the frictional response and the onset of wear
AU - Looijmans,S.F.S.P.
AU - Anderson,P.D.
AU - van Breemen,L.C.A.
M3 - Poster
Looijmans SFSP, Anderson PD, van Breemen LCA. Contact mechanics of polyolefins: effect of pre-stretch on the frictional response and the onset of wear. 2018.


The law of attraction works with momentum. Things may be manifested instantly or it may take a longer time to happen. Why?
The reason has a lot to do with the strength of your desire, the clarity of your vision and the power of your intention. Remember that the Universe will orchestrate and rearrange itself to bring to you all that you want but it will also allow you to wrangle with your choices and all the different aspects, elements and options that your mind may conceive.
Napoleon Hill, the author of 'Think & Grow Rich' said, "fears are nothing more than a state of mind." He forewarned that indecision and doubt can breed fear. The blending of the two, though steady and insidious, may not be obvious to the conscious mind and the end result is fear. Fortunately, fear is a state of the mind that can be altered by conscious thought.
Law Of Attraction: Thoughts Become Things!
My Bubble: Packing Up For Heart Of Asia!
My Poem: My Heart Sings!
Random Bubbles ... MERRY CHRISTMAS!!!
My Bubble: Lassitude & Breakouts!
My Poem: Are We Really The Same?
My Bubble: Will 2011 Close With A Bang For You?


London Rd. and Afton Dr.
Cash 4 You is the trusted and versatile licensed money lender in Canada, with more than 100 convenient locations in Ontario. From personal unsecured loans to payday advance loans, cheque cashing, money orders, Western Union money transfers, and more, our judgment-free team of financial experts will get you the cash you need when you need it most. Stop by our Sarnia store and find out how our loan experts can work for you!
With more than a decade serving Canadians in Sarnia and beyond, we stand by our promise to provide each and every customer with the personalized financial solutions and an unmatched customer service that they want and deserve. Along with providing Canadians everywhere with installment loans, easy payday loans, and cheque cashing options at more than 100 locations in Ontario, we maintain extended business hours our customers can access the cash they need when it is convenient for them. Come see us in Sarnia and experience the Cash 4 You difference!
Need same day cash for a major purchase or to pay off a credit card? Apply for an installment loan from Cash 4 You, where we guarantee a hassle-free loan with no hidden fees, no additional costs, and no closing costs. We offer a simple repayment plan on all loans up to $5,000 that can be paid off over time and under terms that work for you. Apply online and pick your cash up at our Sarnia location once you've been approved. Loan approval is fast and easy, so why wait?
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text:
Saint-Laurent-de-la-Plaine est une ancienne commune française située dans le département de Maine-et-Loire, en région Pays de la Loire, devenue le  une commune déléguée de la commune nouvelle de Mauges-sur-Loire.

Géographie
Commune angevine des Mauges, Saint-Laurent-de-la-Plaine se situe au nord-est de Bourgneuf-en-Mauges, sur les routes , Chalonnes-sur-Loire - Bourgneuf-en-Mauges, et , Saint-Lambert-du-Lattay.

Histoire

Les Mauges, dont fait partie Saint-Laurent-de-la-Plaine, sont habités depuis la Préhistoire. Plus tard, Jules César fait mention d'une tribu des Andes ou Andégaves dans cette région. Elle passe ensuite sous différentes dominations (Saxons, Bretons, Comté de Nantes, Anjou, Angleterre, etc.). Tout bascule véritablement avec la Guerre de Vendée. En 1790, l'Assemblée vote la Constitution civile du clergé. Pendant cette période, la Chapelle est brûlée, mais les rassemblements continuent, et comptent parmi eux Jacques Cathelineau, futur généralissime des armées vendéennes. Le décret du 24 février 1793, connu le 2 mars, déclenche l'insurrection vendéenne. Les registres de la ville de Saint Laurent font état de 113 combattants qui prirent les armes.

La commune nouvelle de Mauges-sur-Loire naît le  de la fusion des 11 communes de la communauté de communes, dont la création a été officialisée par arrêté préfectoral du 5 octobre 2015.

Politique et administration

Administration municipale

Administration actuelle
Depuis le  Saint-Laurent-de-la-Plaine constitue une commune déléguée au sein de la commune nouvelle de Mauges-sur-Loire et dispose d'un maire délégué.

Administration ancienne

Ancienne situation administrative
La commune est membre en 2015 de la communauté de communes du canton de Saint-Florent-le-Vieil, elle-même membre du syndicat mixte Pays des Mauges. L'intercommunalité disparait à la création de la commune nouvelle.

Population et société

Évolution démographique

Pyramide des âges
La population de la commune est relativement jeune. Le taux de personnes d'un âge supérieur à 60 ans (18,8 %) est en effet inférieur au taux national (21,8 %) et au taux départemental (21,4 %).
Contrairement aux répartitions nationale et départementale, la population masculine de la commune est supérieure à la population féminine (50 % contre 48,7 % au niveau national et 48,9 % au niveau départemental).

La répartition de la population de la commune par tranches d'âge est, en 2008, la suivante :
 50 % d'hommes (0 à 14 ans = 22,4 %, 15 à 29 ans = 20,9 %, 30 à 44 ans = 20,9 %, 45 à 59 ans = 19,5 %, plus de 60 ans = 16,3 %) ;
 50 % de femmes (0 à 14 ans = 21,6 %, 15 à 29 ans = 18,6 %, 30 à 44 ans = 20,2 %, 45 à 59 ans = 18,3 %, plus de 60 ans = 21,3 %).

Culture
Le théâtre des Rêveries est un des rares théâtres à posséder un plateau tournant. Construit dans les années 1950, ce plateau permet d'accueillir jusqu'à trois décors, et il est un outil original pour la mise en scène de spectacles.

La troupe du Théâtre des Rêveries : depuis des années, la troupe référente du Théâtre des Rêveries, encadrée par des professionnels du spectacle, présente régulièrement des spectacles de théâtre. Pour la première fois en juillet 2012, l'association du Musée des métiers et la troupe du Théâtre des Rêveries s'associent pour présenter un spectacle en plein air.

Économie
Sur 139 établissements présents sur la commune à fin 2010, 32 % relevaient du secteur de l'agriculture (pour une moyenne de 17 % sur le département), 6 % du secteur de l'industrie, 14 % du secteur de la construction, 43 % de celui du commerce et des services et 6 % du secteur de l'administration et de la santé.

On y trouve notamment l'entreprise Ateliers Perrault Frères.

Lieux et monuments

 Musée des métiers regroupant les plus vieux métiers de France tels le boulanger, le maître d'école.
 La chapelle Notre-Dame-de-Charité (vitraux d'Abel Pineau).

Personnalités liées à la commune
 Raphaële Garreau de Labarre, organiste, native de la commune.

Voir aussi

Articles connexes
 Les Mauges
 Anciennes communes de Maine-et-Loire

Liens externes

 Commune de Saint-Laurent-de-la-Plaine sur le site de l'Insee

Notes et références

Notes

Références

Mauges-sur-Loire
Commune déléguée en Maine-et-Loire


text:
Le mont de Lans est une montagne de l'archipel des Kerguelen, sur la Grande Terre, culminant à  d'altitude.

Géographie

Le mont se situe à l'est du glacier Cook.

Histoire
Le mont de Lans a été reconnu pour la première fois par Polian et Rens lors d'une reconnaissance menée vers le glacier Cook. Il fait référence au mont et à la commune de Mont-de-Lans en Isère d'où était originaire l'un des membres de l'équipe.

Notes et références

Lans
Lans
Grande Terre (archipel des Kerguelen)


text:
Supping with the devil
It's an established dogma of the so-called public health movement that partnering with the alcohol industry to reduce harms is tantamount to supping with the devil. It's not that they think you should use a long spoon, you shouldn't even be at the meal.
It was entirely predictable that when Public Health England (PHE) announced a partnership with Drinkaware to jointly campaign for "drink-free days" to reduce heavy drinking and promote moderate consumption, the usual anti-alcohol groups shrieked in horror.
This alarmist concern resulted in a letter sent to PHE by the Alcohol Health Alliance (AHA) signed by 50 anti-alcohol pressure groups and individuals. The concern arises from the fact Drinkaware is funded by the alcohol industry and therefore, in the view of the AHA, tainted by Big Alcohol. I defy anyone viewing the Drinkaware website to conclude it is an industry shill. The level of paranoia by these single-issue pressure groups verges on the pathological – "don't fraternise with the enemy" is their credo!
Their view is that partnership working with the alcohol industry leads to the dilution of policies that really work and to the substitution of ineffective policies – such as education. So even though the PHE "low risk" drinking guidelines promote drinking no more than 14 units of alcohol a week interspersed by one or two alcohol-free days, and all these groups are signed up to that advice, if the alcohol industry supports it in conjunction with PHE it is tantamount to heresy. So much so professor Sir Ian Gilmore, chairman of the AHA and a key advisor to PHE, threatened to resign his post in protest. If you point a gun to your head and say: "Do as I say or I'll shoot" you run the risk your bluff will be called, and it was. Professor Gilmore has resigned!
It seems to me if the AHA and its membership want to separate itself from the industry that produces the products they profess to be experts on, they will isolate themselves in an academic ivory tower and their policy prescriptions will lack any relevance to the real world in which they are enacted. This bone-headed, know-nothing approach does have one advantage, however, it enables them to make things up in their heads and ensure their own ideological purity by burying themselves deeply in the temperance rabbit hole. This immunises them from any kind of reasoned compromise with an industry they despise as comprised of capitalist bad guys engaged in a conspiracy against public health.
And, of course, the policies they describe as "best buys" for reducing alcohol-related harm are whole-population policies designed to reduce overall consumption through minimum unit pricing, tax rises and bans on advertising and promotions.
Contrast this with the pragmatic approach taken at Walsall NHS Trust. It recognised a disproportionate amount of time and NHS resources were being spent on a small number of "frequent flyers" – people with alcohol problems who turned up at A&E for treatment multiple times. They identified a cohort of just ten patients who were admitted 499 times between them in six months. On average, each patient was admitted twice a week.
Walsall NHS Trust identified 38 frequent flyers whose needs were complex and varied – alcoholism, mental health, family breakdown – and by taking a joined-up approach it was able to achieve a 54% drop in alcohol-related A&E admissions and a 68% reduction in bed days. Overall the trust saved more than £250,000.
Daniel Hodgkiss, patient safety manager at Walsall NHS Trust, said: "We identified a small number of hospital patients with complex needs that were discharged only to return multiple times, which accounted for a very disproportionate number of admissions.
"This was due to a lack of cohesion between social care, mental health services, police and a range of other services. By bringing these agencies together to co-ordinate patient care, we were able to substantially reduce admissions."
This is the kind of pragmatic approach to alcohol-harm reduction we need to see. An approach that recognises the locus of alcohol-related harms lies with a minority of drinkers, the heaviest drinking 4%, who are people with complex needs and for whom drinking is a symptom as much as a cause of their problems. Why aren't the AHA, Alcohol Concern and Alcohol Focus Scotland championing this approach instead of throwing their dummies out of the pram because PHE has, for once, adopted a sensible, partnership approach with the industry?