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Günter Schultz (* 23. Januar 1936 in Frankfurt am Main; † 14. August 2021) war ein deutscher Pharmakologe. Er hatte wesentliche Erkenntnisse über die biologische Signalverarbeitung gewonnen. Außerdem hatte er zahlreiche Jüngere zu diesem Forschungsgebiet hingeführt und es so vor allem in Deutschland mitgeprägt.

Leben
Seine Eltern waren der Arzt Ernst-Gottfried Schultz und dessen Ehefrau Margarete geb. Eichner. Nach dem Besuch des Charlottenburger Gymnasiums und dem Abitur 1955 studierte er an der Freien Universität Berlin Medizin. 1963 erhielt er die Approbation als Arzt und wurde mit einer Dissertation "Untersuchungen über das morphologische und sekretorische Verhalten der Corpusschleimhaut des Magens bei chronischer Hepatitis und Lebercirrhose" zum Dr. med. promoviert. Er trat in die Arbeitsgruppe von Gerhard Senft (1926–1967) an dem von Hans Herken geleiteten Pharmakologischen Institut der Freien Universität ein. Nach Senfts Tod wechselte er 1968 an das Pharmakologische Institut der Ruprecht-Karls-Universität Heidelberg, dessen Leitung im selben Jahr Franz Gross übernahm. In Heidelberg habilitierte er sich 1970 für Pharmakologie mit einer Arbeit "Wirkungen von Hormonen und Pharmaka auf den Stoffwechsel cyclischer Nucleosid-3'-5'-monophosphate in der Rattenniere". 1970 heiratete er auch die medizinisch-technische Assistentin Karin Munske (1941–2009), Mitarbeiterin in seiner Gruppe und Ko-Autorin einiger Publikationen erst unter ihrem Mädchennamen, dann als Karin Schultz. Von 1971 bis 1973 arbeitete er als Visiting Scientist (Gastwissenschaftler) bei Earl Wilbur Sutherland in der Gruppe von Joel Griffith Hardman (* 1933) an der Physiologischen Abteilung der Vanderbilt University in Nashville, Tennessee. Sutherland hatte um 1960 das cyclische Adenosinmonophosphat (cAMP) als einen second messenger bei der Wirkung chemischer Botenstoffe wie des Adrenalins sowie das cAMP-bildende Enzym Adenylylcyclase und das cAMP-spaltende Enzym Phosphodiesterase entdeckt und dafür 1971, im Jahr als Schultz in sein Labor eintrat, den Nobelpreis für Physiologie oder Medizin erhalten. Von 1973 bis 1983 bekleidete Schultz eine C3-Professur in Heidelberg, verbrachte aber wieder einige Monate an der Vanderbilt University. 1983 wurde er als C4-Professor – ordentlicher Professor – an die Freie Universität Berlin berufen und folgte am 1. Oktober Hans Herken als Direktor des Pharmakologischen Instituts an der Thielallee in Dahlem. 2003 wurde er pensioniert. Die Übergabe des Lehrstuhls an seinen Nachfolger Walter Rosenthal, den Leiter des Berliner Forschungsinstituts für Molekulare Pharmakologie, späteren Leibniz-Instituts für Molekulare Pharmakologie, fiel in die schwierige Zeit der Zusammenlegung der Medizinischen Fakultäten der Freien Universität und der Humboldt-Universität.

Forschung

Diuretika, cyclisches AMP und die Phosphodiesterase
Senft interessierte sich für Diuretika. Manche, besonders die Thiaziddiuretika sowie das chemisch verwandte, allerdings nicht diuretisch wirkende Diazoxid, erhöhten den Blutzuckerspiegel. Die Berliner Gruppe erwog, dass dabei cAMP eine Rolle spielen könnte, das den Kohlenhydratstoffwechsel regelt. Schultz baute eine Methode zur Messung von cAMP auf. In der Tat hemmten sowohl Diazoxid als auch die Thiaziddiuretika die cAMP-abbauende Phosphodiesterase. Vermutlich ist Phosphodiesterase-Hemmung nicht die Hauptursache für die Blutzuckerwirkung der Thiazide und des Diazoxids. Schultz aber hatte mit diesen Arbeiten zu seinem Thema gefunden, der biologischen Signalverarbeitung.

Cyclisches GMP und die Guanylylcyclase
Kurz bevor er Berlin verließ, war ein zweites cyclisches Nucleotid entdeckt worden, das cyclische Guanosinmonophosphat (cGMP). Ihm wandte sich Schultz in Heidelberg zuerst zu. "In den letzten Jahren wurde die Ausscheidung von cyclischem Guanosin-3',5'-monophosphat [..] im Urin von Ratten beschrieben […]. Über Bildung und Vorkommen dieses cyclischen Nucleotids in tierischen Geweben ist bisher nichts bekannt." Schultz und seine Mitarbeiter, darunter sein erster Doktorand Eycke Böhme (1943–1993), entdeckten "Bildung und Vorkommen" – und damit die cGMP-bildende Guanylylcyclase, genauer die im Zytosol gelöste Guanylylcyclase – gleichzeitig mit zwei US-amerikanischen Gruppen, darunter Hardman und Sutherland, in vielen Organen. Die Guanylylcyclase ist das Gegenstück zur cAMP-bildenden Adenylylcyclase. Sie existiert in mehreren Isoformen. An deren Reinigung und Charakterisierung bis zur Strukturaufklärung durch Klonierung ihrer Gene hat die Gruppe in Heidelberg und später Berlin weiter mitgewirkt.

Auf der Suche nach der Funktion von cGMP fand Schultz in Nashville, dass im Samenleiter von Ratten Noradrenalin, Acetylcholin und Carbachol, die das Organ zur Kontraktion bringen, den Gehalt an cGMP steigerten. cGMP war aber keineswegs ein second messenger für die Kontraktion – im Gegenteil. Das wurde 1977 klar. Wie Schultz' Gruppe und die Gruppe von Ferid Murad in den USA fanden, erhöhten auch mehrere Stoffe, die die glatte Muskulatur erschlaffen lassen, insbesondere die Nitrovasodilatatoren, den Gehalt an cGMP. Außerdem bewirkte ein cGMP-Derivat selbst Erschlaffung. cGMP war also ein second messenger nicht für Kontraktion, sondern für Erschlaffung. Ab 1980 wurde mit der Erkennung von Stickstoffmonoxid als dem körpereigenen Aktivator der zytosolischen Guanylylcyclase – anders ausgedrückt mit der Erkennung der zytosolischen Guanylylcyclase als des Rezeptors für körpereigenes Stickstoffmonoxid – die große physiologische Bedeutung des Enzyms klar.

Hemmung der Adenylylcyclase
Adrenalin löst seine Wirkungen über zwei Typen von Rezeptoren aus, die α- und β-Adrenozeptoren. Sutherlands Stimulation der Adenylylcyclase geschieht über β-Adrenozeptoren. Was die α-Adrenozeptoren angeht, so hatte man um 1970 beobachtet, dass ihre Aktivierung den cAMP-Gehalt von Organen verminderte. An Membranen von Thrombozyten (Blutplättchen) erforschten Schultz und sein zweiter Heidelberger Doktorand Karl-Heinrich Jakobs (* 1941) den Mechanismus. Er bestand in einer Hemmung der Adenylylcyclase. Es gab also eine gegenläufige biologische Signalverarbeitung über das Enzym, Stimulierung und Hemmung. Über β-Adrenozeptoren und Stimulierung der Adenylylcyclase hemmte Adrenalin die Thrombozytenaggregation, über α-Adrenozeptoren und Hemmung der Adenylylcyclase dagegen förderte es die Thrombozytenaggregation. Die α-Adrenozeptoren unterschieden sich von jenen, die Glattmuskelkontraktion auslösen, und wurden 1979 als α2-Adrenozeptoren identifiziert.

G-Proteine

Gs, Gi und darüber hinaus
Ebenfalls seit etwa 1970 war bekannt, dass Adrenalin und andere Botenstoffe wie Glukagon die Adenylylcyclase nur in Gegenwart von Guanosintriphosphat (GTP) stimulierten, wobei GTP in Guanosindiphosphat (GDP) und Phosphationen gespalten wurde. GTP trat dazu nicht mit dem Rezeptor oder der Adenylylcyclase in Kontakt, sondern mit einem separaten Proteinkomplex aus drei verschiedenen Untereinheiten α, β und γ, einem heterotrimeren G-Protein (GTP-bindenden Protein). Auch die Hemmung der Adenylylcyclase in Blutplättchen durch Adrenalin erwies sich als GTP-abhängig. Außer über α2-Adrenozeptoren wird die Adenylylcyclase über manche Muscarinrezeptoren, Rezeptoren für den Neurotransmitter Acetylcholin, gehemmt, zum Beispiel im Herzen. Wiederum erforderte die Hemmung die Anwesenheit von GTP. Die Frage der G-Protein-Forschung um 1980 lautete "whether the same, or distinct, G-proteins confer activating and attenuating signals to the adenylate cyclase enzyme", ob es ein und dasselbe G-Protein ist oder verschiedene G-Proteine sind, die einerseits stimulierende, andererseits hemmende Signale an die Adenylylcyclase weitergeben.

Zwei Heidelberger Experimente von Schultz, Jakobs und einem Post-Doktoranden, Klaus Aktories, entschieden 1983 für verschiedene G-Proteine. Das erste wurde an Lymphomzellen durchgeführt, deren Adenylylcyclase eines Gendefekts wegen auf stimulierende Botenstoffe nicht mehr reagierte. Der Adenylylcyclase-hemmende Botenstoff Somatostatin dagegen verursachte bei diesen Zellen die übliche Hemmung: Es fehlte des Gendefekts wegen das stimulierende G-Protein Gs – "s" für – "stimulierend", nicht aber das davon verschiedene inhibierende G-Protein Gi – "i" für "inhibierend". Das zweite Experiment wurde an Blutplättchen durchgeführt, deren Adenylylcyclase, wie oben erwähnt, durch Adrenalin über α2-Adrenozeptoren gehemmt wird. Das Prostaglandin Prostaglandin-E1 stimuliert die Blutplättchen-Adenylylcyclase. Ein bakterielles Toxin, das vom Erreger des Keuchhustens stammende Pertussistoxin, verhinderte die Hemmung durch Adrenalin und die begleitende Spaltung von GTP zu GDP und Phosphationen, nicht aber die Stimulierung durch Prostaglandin-E1: Pertussistoxin blockierte Gi, nicht aber das davon verschiedene Gs.

Die G-Proteine wurden weltweit eines der intensivst beforschten biologischen Themen. 1983 kannte man drei, Gs, Gi und das in den Photorezeptorzellen der Netzhaut der Lichtwahrnehmung dienende Transducin. 1984 kam ein weiteres hinzu, das wie Gi durch Pertussistoxin blockiert wurde, Go, in dessen Bezeichnung "o" für "other" steht, "ein anderes" G-Protein. Vor allem durch Klonierung der Gene wurde die Vielfalt immer größer. 2005 waren 17 verschiedene Gene für α-, 5 verschiedene Gene für β- und 12 verschiedene Gene für γ-Untereinheiten bekannt, aus denen durch alternatives Spleißen eine noch größere Zahl von Proteinen resultierte. Die aus ihnen zusammengesetzten Heterotrimere teilt man nach den α-Untereinheiten in vier Klassen ein, Gs, Gi/o, Gq/11 und G12/13. Über fast tausend "G-Protein-gekoppelte Rezeptoren" können Botenstoffe, auch viele Arzneistoffe, auf die G-Proteine und dadurch weiter auf "Effektoren", also Enzyme oder Ionenkanäle wirken.

Gi, Go und die Modulation von Calciumkanälen
Schultz zeigte 1987 und 1988 in Berlin zusammen mit Walter Rosenthal und den Homburger Elektrophysiologen Wolfgang Trautwein und Jürgen Hescheler (* 1959) erstmals eine Beeinflussung spannungsgesteuerter Calciumkanälen durch G-Proteine, zunächst bei Nervenzellen. Ein Opioid hemmte den Eintritt von Calciumionen in die Zellen. Die Hemmung wurde durch Pertussistoxin blockiert. Wurde ein Gemisch von Gi und Go in die Pertussistoxin-behandelten Zellen injiziert, so trat die Hemmung durch das Opioid wieder auf: Die Hemmung wurde durch das injizierte Gi-Go-Gemisch "rekonstituiert". Die Veröffentlichung erregte sogleich Aufsehen, zumal das verantwortliche G-Protein anscheinend Go war, dem damit erstmals eine Rolle bei der Signalverarbeitung zugeschrieben werden konnte.

Die gegenteilige Rolle spielten G-Proteine in der Nebennierenrinde. In deren Zellen steigerte Angiotensin II den Calciumeintritt durch spannungsabhängige Calciumkanäle, und Pertussistoxin blockierte die Steigerung. Immunologisch ließ sich Go ausschließen und ein Gi-Protein identifizieren. In einer weiteren endokrinen Drüse schließlich, dem Hypophysenvorderlappen – "GH3"-Zellen aus einem Hypophysenvorderlappentumor von Ratten – wurde der Calciumeintritt durch Somatostatin gehemmt und durch LHRH – das Luteinisierungshormon-freisetzende Hormon – gesteigert. Pertussistoxin blockierte die Hemmung wie die Steigerung. Hemmung und Steigerung wurden anscheinend durch verschiedene G-Proteine vermittelt, denn die Zellen enthielten sowohl Go als auch ein Gi-Protein.

Selektivität und Komplexität
Aus der unübersehbaren Zahl von G-Protein-Untereinheiten und G-Protein-Heterotrimeren wählen Zellen bestimmte, für ihre jeweilige Funktion adäquate Kombinationen. Das wurde zuerst durch eine "surprising series of experiments", "eine staunenerregende Versuchsserie" an GH3-Hypophysenvorderlappenzellen deutlich. Deren Calciumkanäle werden außer, wie oben erwähnt, über Somatostatin-Rezeptoren auch über Muscarinrezeptoren gehemmt. Schultz injizierte mit dem Molekularbiologen Burghardt Wittig, ihrer beider Doktorandin Christiane Kleuss und anderen in die Zellkerne von GH3-Zellen Antisense-Oligonukleotide zur präzisen Unterdrückung der Synthese bestimmter G-Protein-Untereinheiten, zunächst α-, dann β-, schließlich γ-Untereinheiten und behandelte die Zellen dann mit Somatostatin oder Carbachol. Die Schlussfolgerung in der dritten Publikation: "Bei jedem der beiden Signalübersetzungswege ist anscheinend eine spezifische γ-Untereinheit mit einer spezifischen β-Untereinheit und einer spezifischen αo-Untereinheit komplexiert, so dass zwei spezifische G-Proteine resultieren. … Der Muscarinrezeptor ist an ein aus αo1/β3/γ4 bestehendes, der Somatostatin-Rezeptor an ein aus αo2/β1/γ3 bestehendes G-Protein gekoppelt. Beide G-Proteine vermitteln eine Hemmung spannungsabhängiger Calciumkanäle."

Mit derselben Methode untersuchte Schultz' Gruppe die Signalverarbeitung an den GH3-Rezeptoren für TRH – das Thyreotropin-freisetzende Hormon. TRH förderte wie LHRH (siehe oben) den Calciumeintritt. Die Wirkung, genauer der durch Pertussistoxin hemmbare Teil der Wirkung, wurde durch G-Proteine mit den α-Untereinheiten αi2 und αi3 vermittelt.

Der Doktorand Karl-Ludwig Laugwitz (* 1968) und der Post-Doktorand Stefan Offermanns entwickelten eine weitere Methode zur Analyse von G-Proteinen, Photoaffinitätsmarkierung gefolgt von immunologischer Identifizierung. Damit wurde die Signalverarbeitung an den Rezeptoren der Schilddrüse für das die Drüse stimulierende Thyreotropin untersucht. Effektoren sind dabei die Adenylylcyclase, die den second messenger cAMP bildet, und eine Phospholipase C, die die second messenger Inositoltrisphosphat und Diacylglycerin bildet. Beide Enzyme werden durch Thyreotropin stimuliert. G-Protein-Analyse ergab zunächst, dass daran die G-Protein-Klassen Gs und Gq/11, im weiteren, dass auch die Klassen Gi/o und G12/13 beteiligt waren, mit insgesamt zehn verschiedenen α-Untereinheiten, ein, wie die Autoren schreiben, unerwarteter Befund, der zeige, dass neben spezifischen auch multiple Rezeptor-G-Protein-Kopplungen vorkommen.

Spezifisch hingegen waren Signalkaskaden bei der Wirkung von Thromboxan A2 und Adenosindiphosphat auf Blutplättchen. Beide sind wichtige Mediatoren der Thrombocytenaggregation. Thromboxan A2 aktivierte neben anderen G-Proteinen G12 und G13; das war – 1994 – der erste Nachweis einer biologischen Funktion dieser beiden G-Proteine. Spezifisch über G13 und die kleine GTPase Rho als Effektor löste Thromboxan A2 dann den mit der Aggregation einhergehenden Formwandel der Plättchen aus. Adenosindiphosphat dagegen hemmte über seinen Rezeptor, den "Purinozeptor" P2Y12, und Gi2 die Adenylylcyclase.

Auch an der Kontraktion der glatten Muskulatur von Blutgefäßen durch Endothelin-1 waren G12/13 und als Effektor die kleine GTPase Rho beteiligt.

Selektivität und Komplexität – "Diversity and Selectivity": "Mit der Vorstellung einer linearen Signalübersetzung – ein Rezeptor koppelt sich an ein G-Protein, das dann einen Effektor aktiviert – lassen sich die experimentellen Befunde nicht erklären. … G-Protein-vermittelte Signalverarbeitung ist vielmehr ein komplexes Netzwerk mit Divergenzen und Konvergenzen bei jedem Schritt, vom Rezeptor zum G-Protein zum Effektor."

TRP-Kanäle
Schultz' jüngstes Forschungsgebiet, ab Beginn der 1990er Jahre, geht auf Mutageneseuntersuchungen an der Taufliege Drosophila melanogaster zurück. Eine von zahlreichen Mutationen hatte dazu geführt, dass die Photorezeptoren auf Belichtung mit einem zu kurzen elektrischen Strom antworteten, einem transient receptor potential; helles Licht blendete die Fliegen deshalb. 1985 bis 1989 hatte man als Ursache das Fehlen eines neuartigen Calciumkanals erkannt, eines TRP-Kanals, transient receptor potential channel, benannt nach der Fehlfunktion bei seiner Deletion. Angesichts der Bedeutung von Calcium bei der biologischen Signalverarbeitung begann sogleich die Suche nach ähnlichen Ionenkanälen bei Säugern. 1995 berichteten zwei US-amerikanische Gruppen über die Klonierung eines dem Drosophila-trp-Gen homologen menschlichen Gens. Schultz' Gruppe folgte 1996, ging aber weiter, exprimierte das homologe Gen in tierischen Zellen (CHO-Zellen) und erhielt in der Tat einen Kationenkanal – den ersten TRP-Kanal von Säugern, TRPC1. Besonderes Interesse gewann er, weil die Autoren vermuteten, er könne jener Kanal in der Zellmembran sein, durch den Zellen ihre Calciumspeicher nach Entleerung wieder auffüllen, der CRAC-Kanal, calcium release actived calcium channel, oder speichergesteuerte Kanal, store-operated channel.

Nach 1995 bis 1996 proliferierte die TRP-Forschung rasch. Schultz' Gruppe hat erheblich zur Klonierung und Charakterisierung etlicher der heute (2013) bekannten 26 TRP-Proteine beigetragen. Zur Bildung der CRAC-Kanäle scheinen außer TRP-Kanälen der TRPC-Familie weitere Proteine beizutragen. Kandidaten als chemische Signale für die Öffnung der CRAC-Kanäle sind die durch Phospholipase C gebildeten second messenger Inositoltrisphosphat und Diacylglycerin. In der Tat öffnete Diacylglycerin TRPC3- und TRPC6-Kanäle. Aber auch ganz andere Reize, chemische wie physikalische, öffnen manche TRP-Kanäle, so Kälte und Hitze, das ein Wärmegefühl hervorrufende Capsaicin und das ein Kältegefühl hervorrufende Menthol. Der OTRPC4- oder TRPV4-Kanal, den Schultz Gruppe klonierte, reagierte auf Änderungen des osmotischen Drucks im Extrazellularraum.

Im Jahr 2000 haben Schultz und Mitarbeiter die TRP-Kanäle in eine Ordnung mit drei Familien gebracht, die mit Erweiterungen – sechs Familien – Bestand hat.

Forschungsorganisation
Zusätzlich zu seiner Tätigkeit als Arbeitsgruppenleiter und Institutsdirektor hinaus widmete sich Schultz übergeordneten Aufgaben. 1988 gründete er den Forschungsschwerpunkt der Deutschen Forschungsgemeinschaft "Molekulare Mechanismen der Signaltransduktion in Membranen", den er bis 1994 koordinierte. Aus dem Forschungsschwerpunkt ging 1994 der bis 2005 bestehende Sonderforschungsbereich 366 (SFB 366) "Zelluläre Signalerkennung und -umsetzung" hervor, mit dem Biochemiker Werner Reutter als Sprecher und Schultz als stellvertretendem Sprecher. Zeitweilig gehörten ihm acht Teilprojekte aus dem Pharmakologischen Institut an. Im Rahmen der Dahlem-Konferenzen veranstaltete der SFB jährlich internationale Tagungen über "Signaltransduktion". Von 1994 bis 2000 war Schultz im Senat der Deutschen Forschungsgemeinschaft. Er war lange Hauptherausgeber der Zeitschrift Molecular and Cellular Endocrinology und der Buchreihe Reviews of Physiology, Biochemistry and Pharmacology.

Schüler
Folgende Wissenschaftler haben sich in Schultz' Heidelberger Arbeitsgruppe oder seinem Berliner Institut habilitiert (Jahr der Habilitation):
 Franz Hofmann (1977), später Lehrstuhlinhaber für Pharmakologie und Toxikologie der Technischen Universität München und Gründungsdirektor des Berliner Forschungsinstituts für Molekulare Pharmakologie; Hofmanns Habilitation wurde von Franz Gross mitbetreut
 Eycke Böhme (1978), später Professor am Berliner Institut; auch seine Habilitation wurde von Franz Gross mitbetreut
 Karl Heinrich Jakobs (1979), später Lehrstuhlinhaber für Pharmakologie und Toxikologie der Universität-Gesamthochschule Essen
 Klaus Aktories (1983), später Lehrstuhlinhaber für Pharmakologie und Toxikologie der Universität des Saarlandes in Homburg und dann der Albert-Ludwigs-Universität Freiburg
 Walter Rosenthal (1990), später zu Schultz Nachfolger berufen und seit 2009 Direktor des Max-Delbrück-Centrums für Molekulare Medizin in Berlin-Buch
 Roland Seifert (1992), später Lehrstuhlinhaber für Pharmakologie und Toxikologie der Universität Regensburg und dann der Medizinischen Hochschule Hannover
 Doris Koesling (1996), später Lehrstuhlinhaberin für Pharmakologie und Toxikologie der Ruhr-Universität Bochum
 Bernd Nürnberg (1997), später Lehrstuhlinhaber für Biochemie und Molekularbiologie der Heinrich-Heine-Universität Düsseldorf und dann Lehrstuhlinhaber für Pharmakologie und Experimentelle Therapie der Eberhard Karls Universität Tübingen
 Thomas Gudermann (1998); später Lehrstuhlinhaber für Pharmakologie und Toxikologie der Philipps-Universität Marburg und dann der Ludwig-Maximilians-Universität München
 Stefan Offermanns (1998), später Lehrstuhlinhaber für Pharmakologie und Toxikologie der Ruprecht-Karls-Universität Heidelberg und dann Direktor des Max-Planck-Instituts für Herz- und Lungenforschung in Bad Nauheim
 Torsten Schöneberg (2001), später Lehrstuhlinhaber für Molekulare Biochemie der Universität Leipzig
 Michael Schaefer (2001), später Lehrstuhlinhaber für Pharmakologie und Toxikologie der Universität Leipzig
 Christian Harteneck (2003), später Professor für Pharmakologie in Tübingen

Anerkennung
1994 erhielt Schultz den Max-Planck-Forschungspreis und 1999 den Feldberg-Preis für britisch-deutschen wissenschaftlichen Austausch. 2001 wurde er Mitglied der Deutschen Akademie der Naturforscher Leopoldina. 2003 wurde er mit dem Bundesverdienstkreuz 1. Klasse ausgezeichnet.

Literatur
 Eberhard Hackenthal, Stefan Offermanns, Günter Schultz: Pharmakologisches Institut, Medizinische Fakultät der Ruprecht-Karls-Universität Heidelberg. In: Athineos Philippu (Hrsg.): Geschichte und Wirken der pharmakologischen, klinisch-pharmakologischen und toxikologischen Institute im deutschsprachigen Raum, S. 329–336. Berenkamp-Verlag, Innsbruck 2004. ISBN 3-85093-180-3.
 Helmut Kewitz, Helmut Coper, Diether Neubert, Eckard Oberdisse, Konrad Keller, Günter Schultz: Institut für Pharmakologie, Fachbereich Humanmedizin der Freien Universität Berlin. In: Athineos Philippu (Hrsg.): Geschichte und Wirken der pharmakologischen, klinisch-pharmakologischen und toxikologischen Institute im deutschsprachigen Raum, S. 47–58. Berenkamp-Verlag, Innsbruck 2004. ISBN 3-85093-180-3.

Einzelnachweise

Pharmakologe
Hochschullehrer (Freie Universität Berlin)
Mediziner (20. Jahrhundert)
Mediziner (21. Jahrhundert)
Mitglied der Leopoldina (21. Jahrhundert)
Träger des Bundesverdienstkreuzes 1. Klasse
Absolvent der Freien Universität Berlin
Deutscher
Geboren 1936
Gestorben 2021
Mann
Max-Planck-Forschungspreisträger


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Furthermore, thanks to a longstanding social, political and trading history between the UK and Sri Lanka, there are already strong ties between the two nations that make Sri Lanka an especially attractive prospect for UK businesses. English is widely spoken amongst the country's workforce and, thanks to much of the burgeoning middle class already having familial ties to the UK, there is already a good level of cultural understanding.
Plus, as a UK investor, you'll be in distinguished company, as over 100 important companies with UK affiliation, from a wide range of business sectors, have already made Sri Lanka their home, such as Marks and Spencer Clothing, HSBC, GlaxoSmithKline, Standard Chartered Bank and Rolls Royce.
You can find out more about the specific benefits to UK businesses of investing in Sri Lanka via the Department for International Trade's online booklet, entitled Doing Business in Sri Lanka: Sri Lanka Trade and Export Guide.
It's undeniable that Sri Lanka offers a fantastic business investment opportunity for any British company wishing to expand into the Asian or global markets, but before taking such a momentous step, it's always advisable to go and experience the country for yourself. Hence the reason BRISLA decided to arrange this forthcoming trade mission; to enable potential investors like yourself to encounter the opportunities in person.
As part of the trade mission, thanks to our good friends in Colombo at the British High Commission and the Department for International Trade, we've put together an impressive itinerary, offering potential investors an unmissable opportunity that just could not be achieved if travelling alone. Delegates will be able to take part in a programme of events that includes a series of seminars and lectures given by eminent speakers including government ministers, civil servants and prominent company directors or CEOs, as well as more informal networking events and visits to relevant business premises or projects.
Moreover, by splitting the delegates into two streams – those who wish to import from Sri Lanka and those who wish to export from the UK – we've managed to create two targeted programmes of events that will be both informative and relevant to the specifics of your business. And provided we're notified in advance, delegates will even be able to attend sessions from the other programme, creating a truly bespoke experience that will provide you with all the information you need to make an informed decision.
But despite the amazing trade and business prospects that this trip will offer, it won't be all work and no play. In addition to an excursion to a popular tourist attraction on the final day of the trip, attendees will be offered very favourable rates to stay in the 5-star Cinnamon Grand Hotel, meaning that your business deals can be brokered in luxurious surroundings with the most delicious food and drink available too.
On top of that, there will be plenty of opportunities to sample the atmosphere and culture of Sri Lanka's capital city and see some of the city's landmarks, so it's the perfect way to get a taste for this vibrant country whilst doing something productive and – with a bit of luck – profitable too! Plus, thanks to the incredibly discounted rates we're able to offer on the cost of air fares, accommodation and all other expenses, you'll be able to do it for much less than you ever thought possible.
Hence, if you're a UK based business and think that Sri Lanka might just be the perfect investment opportunity you've been searching for, then why not get in touch with BRISLA today to find out more? We will happily send you some further information including the specifics of the trip and the itinerary and would be happy to answer any questions you might have.
You can get in touch with our Chairman and President, Dr Zimar Sivardeen, by completing the contact form on the website, by emailing him at chairman@brisla.org.uk or by phoning him on 07887 902902.
Sri Lankan Sinhalese and Tamil New Year's Celebrations.


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Game of Thrones Castles You Can Actually Visit in Real Life!
January 12, 2022 Luke Franklin Blogs Leave a comment
Game of Thrones (2011) is one of the fantastic shows with the highest viewership. And something that made it even more favourable is the costumes worn by the cast and shooting locations. However, the costume design is still easy to match, but the location is something that many shows couldn't think about shooting at. Rather than using VFX and shooting the show in a congested studio, the GOT team decided to shoot the entire show at real-life castles to represent Westeros. And, if you are a GOT fan, you would definitely love to visit these Game of Thrones castles at least once in your life.
In all seasons of GOT, we got a chance to watch countless stunning castles that made us wanderlust. From introducing Winterfell castle to Dorne castle, the show's production team has spared no expense finding the best castles and preparing them to be a part of the show. And the best part is that you can visit many of all Game of Thrones castles and feel nostalgic.
So, pack your bag and get excited because we are taking you through a list of famous Game of Thrones castles that you can actually visit in real life.
1 1. Gosford Castle, Northern Island:
2 2. Shane's Castle, Northern Island:
3 3. Alcazar Of Seville, Spain:
4 4. Castell De Santa Florentina, Spain:
5 5. Castillo De Trujillo, Spain:
6 6. Doune Castle, Scotland:
7 7. Castle of Zafra, Spain:
8 8. Castle Ward, Northern Ireland:
9 9. Lovrijenac Fortress, Croatia:
10 10. Ait Benhaddou, Morocco:
11 11. Dunluce Castle, Northern Ireland:
11.1 You Might Also Be Interested In
11.2 Nearby Castles
1. Gosford Castle, Northern Island:
"Gosford Castle", by Robert Ashby, is licensed under CC BY-SA 2.0
Gosford Castle is a beautiful 19th-century country house based in Northern Ireland, which Game of Thrones recognises as Riverrun. The Riverrun was seen in Season 3 of the show as Catelyn Stark's childhood home.
In 2006, the castle made a new debut with its sale price, i.e. $656,452, and for its one of the most extensive renovations that made the space counted as one of the 23 luxury residences in Northern Ireland. The castle was then sold for an undiscovered price, but it is still open for visitors to explore.
2. Shane's Castle, Northern Island:
"Shane's Castle, County Antrim", by Kenneth Allen, is licensed under CC BY-SA 2.0
Shane's Castle is one of the castles in Game of Thrones by a radicalised high sparrow, who forced all the prisoners to confess in favour of him. Also, it's the same castle where Cersei nearly found her match.
The Shane's Castle was originally built in the year 1345, and now it has a crumbling structure. If you plan to visit the Northeastern shores of Lough Neagh in Northern Island, don't forget to check out this castle of Game of Thrones.
3. Alcazar Of Seville, Spain:
"Alcázar of Seville", by Anna & Michal, is licensed under CC BY 2.0
The Alcazar of Seville was built for King Peter of Castile and had a pure royal touch. This Spain based castle was also a part of Game of Thrones castles and appeared as one of the palaces of Dorne. Although Drone was not a very lovable character among fans, this castle attained a top position in the list of most beautiful locations seen in the show.
The Architecture of Alcazar of Seville is Ornate, inspired by Muslim Moores, who was once the owner of this royal castle. Now, it is a beautiful home of Spain's royal family.
4. Castell De Santa Florentina, Spain:
"Castell De Santa Florentina", by Jordi Domènech, is licensed under CC BY 3.0
Castell De Santa Florentina is located outside Spain, and you will also notice it in the 6th season of the Game of Thrones Series. This castle has served as Horn Hill, which was an ancestral house of Samwell Tarly. Sam brought Ginny to this castle, his home, to meet his family.
It is one of the ancient castles in the game of thrones with the Roman Domus foundation. You can tour or rent this castle at your convenience.
5. Castillo De Trujillo, Spain:
"Castillo de Trujillo", by Discasto, is licensed under CC BY-SA 4.0
Although you will notice Casterly Rock throughout the Game of Series, the Castillo De Trujillo castle is shown in the series in the 7th season. You can notice it when Daenerys Targaryen's Unsullied army attacked the Lannister Home.
This Game of thrones castle is built over the old Muslim Citadel, the medieval Moorish stone and is located at the highest point of Cáceres. Its structure has eight towers and a horseshoe arch.
6. Doune Castle, Scotland:
"Doune Castle", by Christian Kadluba, is licensed under CC BY-SA 2.0
There are chances that you must have missed Doune Castle in the Game of Thrones series, but it stood in for a section of Winterfell, the Ancestral home of Starks, during the pilot episode. The shooting for the scene where Jamie Lannister pushes Bran out of the window, saying, "The things we do for love." is also done in its tower.
It is one of the famous Scotland based Game of Thrones Castle, built in the 14th century as Home of Regent Albany, the uncrowned king of Scotland. When you visit this castle, you get a chance to explore its steep, cobbled tunnel, courtyard, and cellar.
7. Castle of Zafra, Spain:
"Castillo de Zafra", by Diego Delso, is licensed under CC BY-SA 4.0
The castle of Zafra is noticed at the Tower of Joy in the Game of Thrones series. It is where you will notice this one of the beautiful Game of Thrones castles. In the 3rd episode of the 6th season of the show, the young Ned Stark and his bannermen fought Ser Arthur Dayne and Ser Gerold Hightower in the flashback of Bran Stark.
The castle of Zafra was built in the 12th century in a little village of Campillo De Duenas, Spain. The best part is that it is unearthed, and visitors can explore it.
8. Castle Ward, Northern Ireland:
"Castle Ward – Classical Facade", by Amanda Slater, is licensed under CC BY-SA 2.0
Castle Ward is one of the most famous Game of Thrones castles because it is the first location in the show. It played a part of Winterfell in the pilot and can be seen throughout the 1st season of this show. Also, after the airing of 1st season, this castle has become the home of many GOT fans.
People can sign up for one of the Winterfell Tours to explore this 18th-century castle. It gives a chance to explore the full-on immersive Game of Thrones vibes and dress up as your favourite character of the show.
9. Lovrijenac Fortress, Croatia:
"Lovrijenac Fortress", by aiva., is licensed under CC BY 2.0
Lovrijenac Fortress is famously known as Dubrovnik's Gibraltar and was seen at the start of Season 2 of the show when all Landings of the King were shot in the Mediterranean Coastal city Dubrovnik. Even it was the location for the biggest battles seen in the Game of Thrones show. Now, the town is filled with mediaeval buildings and is a famous tourist attraction.
Although the Red Keep was majorly created through Nifty CGI, the various scenes of Red Keep were filmed at Lovrijenac Fort. In total, this Game of Thrones castle is a combination of amazing views seen from the iconic orange rooftops.
10. Ait Benhaddou, Morocco:
"Ait Benhaddou", by Maureen, is licensed under CC BY 2.0
Ait Benhaddou is one of the most visited places in Morocco, famous for its Ancient touch and clay architecture. Because of its historical and cultural vibes, this city was used in Game of Thrones for representing Yunkai.
It was one of the slave cities in the South captured by Daenerys Targaryen and liberated during her crusade. Although the enemy captured the city, it still represented an important step towards the Iron Throne. You can visit this place to experience amazing architecture, history, and culture.
11. Dunluce Castle, Northern Ireland:
"Dunluce Castle", by Alex Ranaldi, is licensed under CC BY-SA 2.0
Dunluce Castle was one of the castles used in Game of Thrones as the Castle of Pyke, which was the home of Greyjoys on Iron Irelands. Although the castle is ruined now, you can still check out its Carrick-a-Rede bridge that you must have also noticed in the show.
You can visit this castle to explore the remaining architecture. However, as this castle is broken now, don't expect to find it in the same position which you must have watched on the screen. Modern technology was used to make the castle look in perfect condition.
There are also other Game of Thrones castles you must have noticed in the show, such as Peniscola Castle and Castillo Almodovar, but these are our top picks. Whenever you visit the respective countries, don't forget to explore these castles of Game of Thrones and relive all the scenes shot there.
The History of Upton Castle
LocationCosheston, Pembrokeshire, Wales (Google Maps)Open for VisitorsYesOwned byStephen and Prue BarlowOfficial WebsiteUpton CastleRooms AvailableYes (Stay,…
The History of Eynsford Castle
LocationEynsford, Kent, England (Google Map Location)Open for VisitorsYesOwned byEnglish HeritageOfficial WebsiteEynsford CastleRooms AvailableNone Located in…
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On September 30, 2008, the United States Department of Health and Human Services Office of Inspector General ("OIG") published Supplemental Compliance Program Guidance for Nursing Facilities ("CPG"). The CPG is available on the OIG's web site at http://www.oig.hhs.gov/fraud/docs/complianceguidance/nhg_fr.pdf.
In the CPG, the OIG details fraud and abuse risks that nursing home compliance programs should address. The CPG also offers recommendations for the establishment of a proper ethical and compliance culture, for the assessment of the effectiveness of compliance programs, and for proper self-reporting protocols. We recommend that all nursing facilities review the CPG and use it to measure and evaluate existing compliance programs. To assist in that effort, this Advisory discusses the evolution of the CPG, summarizes its contents, and provides a list of suggested action items for consideration.


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Home National Raptors end Bucks' eight-game winning streak with 97-93 victory
Raptors end Bucks' eight-game winning streak with 97-93 victory
TORONTO — Fred VanVleet scored 29 points to lead the short-handed Raptors to a 97-93 victory over Milwaukee on Thursday, snapping the Bucks' eight game winning streak.
The Raptors (10-13) ended a four-game losing skid with just their second win in their last six games, and third at home this season.
Pascal Siakam had 20 points and eight rebounds, while rookie Scottie Barnes had 13. Back after missing two games with a deep calf bruise, Gary Trent Jr. had eight points and eight rebounds.
Jrue Holiday scored 26 points to lead a Bucks team (14-9) that was missing star Giannis Antetokounmpo.
The Raptors were coming off an ugly 98-91 loss to Memphis, dropping five straight at home for the first time since January of 2011. Siakam said after the loss to the Grizzlies that "the fans deserve better."
They were solid out of the gate Thursday, holding the Bucks to a three-point lead then assembling an 11-point lead of their own. They led 73-68 to start the fourth.
The Bucks pulled to within two early in the final frame, but VanVleet almost single-handedly led the Raptors on a 7-0 run to put them up by nine.
A layup by Sandro Mamukelashvili had the Bucks within two with 4:34 to play, but the Raptors buckled down on the defensive end and when VanVleet muscled through a pair of Milwaukee defenders to the basket and scored, the Raptors were back up by six with 3:06 to play. VanVleet raised his hands in the air, encouraging the fans at Scotiabank Arena to cheer. They obliged.
Bobby Portis Jr., however, connected on a three-pointer with 33 seconds to play to slice the difference to three points. VanVleet drained a pair of free throws for some breathing room, but a pair of back-to-back fouls with 14 seconds to play sent the Bucks to free-throw line for five shots. They missed two.
Precious Achiuwa missed a pair of free throws with 3.6 seconds to play, but Barnes grabbed the offensive rebound that all but sealed the victory.
Toronto has been hit hard by injuries. OG Anunoby sat out his eighth straight game with a hip injury, and there's no timeline for his return, while Khem Birch remains out with knee swelling.
The Bucks were also short-handed, missing a trio of big men in Antetokounmpo, Brook Lopez and DeMarcus Cousins.
Trent Jr., who wore one white shoe and one black, made his presence felt immediately, connecting on a three-pointer for the first points of the game.
"Obviously he's a scorer and a shooter and we could use as much of that as we can handle right now, that's for sure," coach Nick Nurse said before the game.
Toronto made six of the 10 shots from long-distance in a solid first quarter, and led 26-23 to start the second.
The Raptors kept up the momentum and when Achiuwa scored on a running dunk, swinging from the rim like a gymnast on the high bar, Toronto went up by eight. The home team went into the locker-room at halftime with a 48-40 lead.
Chris Boucher, who's played sparingly the past few games, missed an easy layup and held his head with both hands in frustration. He hit his next two shots though, including a putback dunk that he followed up with a glare at the TV camera.
While Anunoby still isn't practising after his recovery recently stalled, Nurse sounded more hopeful about Birch.
"I think it's getting better," Nurse said. "He's not in practice or anything but I see him in the gym and it seems like he's working fairly hard so I think it's improving, hopefully he'll be back soon."
The Raptors' season-long seven-game homestand continues on Sunday against Washington. Toronto is at home for 10 of its 13 games in December.
Lori Ewing, The Canadian Press
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With no VanVleet, Siakam narrowly misses triple-double in win over Charlotte
Raptors slice 34-point deficit to just four points before losing to Portland
Raptors' six-game winning streak ends with 99-95 loss to Phoenix Suns


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Roger Federer Photos
2019 US Open Tennis Championships Photos: Friday, August 30, 2019.
August 30, 2019, New York City, NY: Kobe Bryant arrives in the tunnel during the 2019 US Open Tennis Championships at the Billie Jean King National Tennis Center in New York, New York Friday, August 30, 2019. (Photo by Billie Weiss/US Open Tennis Championships)
August 30, 2019, New York City, NY: Roger Federer poses with Kobe Bryant during the coin toss before a match against Dan Evans during the 2019 US Open Tennis Championships at the Billie Jean King National Tennis Center in New York, New York Friday, August 30, 2019. (Photo by Billie Weiss/US Open Tennis Championships)
August 30, 2019, New York City, NY: Roger Federer waits in the tunnel before a match against Dan Evans during the 2019 US Open Tennis Championships at the Billie Jean King National Tennis Center in New York, New York Friday, August 30, 2019. (Photo by Billie Weiss/US Open Tennis Championships)
August 30, 2019, New York City, NY: Roger Federer in action during a match against Dan Evans during the 2019 US Open Tennis Championships at the Billie Jean King National Tennis Center in New York, New York Friday, August 30, 2019. (Photo by Billie Weiss/US Open Tennis Championships)
August 30, 2019, New York City, NY: Serena Williams exits the tunnel as she is introduced before a match against Karolina Muchova during the 2019 US Open Tennis Championships at the Billie Jean King National Tennis Center in New York, New York Friday, August 30, 2019. (Photo by Billie Weiss/US Open Tennis Championships)
August 30, 2019, New York City, NY: Roger Federer reacts after a match against Dan Evans during the 2019 US Open Tennis Championships at the Billie Jean King National Tennis Center in New York, New York Friday, August 30, 2019. (Photo by Billie Weiss/US Open Tennis Championships)
August 30, 2019, New York City, NY: Serena Williams in action during a match against Karolina Muchova during the 2019 US Open Tennis Championships at the Billie Jean King National Tennis Center in New York, New York Friday, August 30, 2019. (Photo by Billie Weiss/US Open Tennis Championships)
August 30, 2019, New York City, NY: Serena Williams reacts during a match against Karolina Muchova during the 2019 US Open Tennis Championships at the Billie Jean King National Tennis Center in New York, New York Friday, August 30, 2019. (Photo by Billie Weiss/US Open Tennis Championships)
August 30, 2019, New York City, NY: Madison Keys is introduced before a match against Sofia Kenin during the 2019 US Open Tennis Championships at the Billie Jean King National Tennis Center in New York, New York Friday, August 30, 2019. (Photo by Billie Weiss/US Open Tennis Championships)
August 30, 2019, New York City, NY: Fans cheer during the 2019 US Open Tennis Championships at the Billie Jean King National Tennis Center in New York, New York Friday, August 30, 2019. (Photo by Billie Weiss/US Open Tennis Championships)
August 30, 2019, New York City, NY: Madison Keys in action during a match against Sofia Kenin during the 2019 US Open Tennis Championships at the Billie Jean King National Tennis Center in New York, New York Friday, August 30, 2019. (Photo by Billie Weiss/US Open Tennis Championships)
August 30, 2019, New York City, NY: Madison Keys reacts after defeating Sofia Kenin during the 2019 US Open Tennis Championships at the Billie Jean King National Tennis Center in New York, New York Friday, August 30, 2019. (Photo by Billie Weiss/US Open Tennis Championships)
August 30, 2019, New York City, NY: Novak Djokovic s introduced as he walks on court before a match against Denis Kudla during the 2019 US Open Tennis Championships at the Billie Jean King National Tennis Center in New York, New York Friday, August 30, 2019. (Photo by Billie Weiss/US Open Tennis Championships)
August 30, 2019, New York City, NY: Denis Kudla in action during a match against Novak Djokovic during the 2019 US Open Tennis Championships at the Billie Jean King National Tennis Center in New York, New York Friday, August 30, 2019. (Photo by Billie Weiss/US Open Tennis Championships)
August 30, 2019, New York City, NY: Novak Djokovic in action during a match against Denis Kudla during the 2019 US Open Tennis Championships at the Billie Jean King National Tennis Center in New York, New York Friday, August 30, 2019. (Photo by Billie Weiss/US Open Tennis Championships)
August 30, 2019, New York City, NY: Serena Williams grips her racquet during a match against Karolina Muchova during the 2019 US Open Tennis Championships at the Billie Jean King National Tennis Center in New York, New York Friday, August 30, 2019. (Photo by Billie Weiss/US Open Tennis Championships)
August 30, 2019, New York City, NY: Novak Djokovic reacts after defeating Denis Kudla during the 2019 US Open Tennis Championships at the Billie Jean King National Tennis Center in New York, New York Friday, August 30, 2019. (Photo by Billie Weiss/US Open Tennis Championships)
August 30, 2019, New York City, NY: Supermodel Adriana Lima attends the 2019 US Open Tennis Championships at the Billie Jean King National Tennis Center in New York, New York Friday, August 30, 2019. (Photo by Billie Weiss/US Open Tennis Championships)
August 30, 2019, New York City, NY: Novak Djokovic reacts during a match against Denis Kudla during the 2019 US Open Tennis Championships at the Billie Jean King National Tennis Center in New York, New York Friday, August 30, 2019. (Photo by Billie Weiss/US Open Tennis Championships)
Another day of action here at the grounds! I was on for the night session, but came in early in the day to catch Roger Federer and a bit of Serena Williams playing in the light (and a quick glimpse of Kobe). Here is my take from the day and night together.
I wish I had a few more days in me here! A big thanks to the US Open and the super talented photo content team for having me on board again. It's always a pleasure. And now the drive back to Boston begins.
August 31, 2019 bjweiss22 Tagged 2019, 2019 US Open Tennis Photos, Adriana Lima, Adriana Lima Photos, Billie Weiss, Billie Weiss Photo, Billie Weiss Photography, Madison Keys, Madison Keys Photos, Novak Djokovic, Novak Djokovic Photos, Photo, Photography, Roger Federer, Roger Federer Photos, Serena Williams, Serena Williams Photos, US Open, US Open 2019, US Open Tennis Championships	Leave a comment
The Championships Wimbledon 2019: Day 2 – July 2, 2019.
July 2, 2019 , Wimbledon, England: Catherine, Duchess of Cambridge attends day 2 of the 2019 Championships Wimbledon at the All England Lawn Tennis Club in Wimbledon, England Tuesday, July 2, 2019. (Photo by Billie Weiss/Wimbledon)
July 2, 2019 , Wimbledon, England: Roger Federer adjusts his hair tie during a match against Lloyd Harris on Centre Court during the 2019 Championships Wimbledon at the All England Lawn Tennis Club in Wimbledon, England Tuesday, July 2, 2019. (Photo by Billie Weiss/Wimbledon)
July 2, 2019 , Wimbledon, England: Catherine, Duchess of Cambridge attends the 2019 Championships Wimbledon at the All England Lawn Tennis Club in Wimbledon, England Tuesday, July 2, 2019. (Photo by Billie Weiss/Wimbledon)
July 2, 2019 , Wimbledon, England: Roger Federer serves during a match against Lloyd Harris on Centre Court during the 2019 Championships Wimbledon at the All England Lawn Tennis Club in Wimbledon, England Tuesday, July 2, 2019. (Photo by Billie Weiss/Wimbledon)
July 2, 2019 , Wimbledon, England: A fan cheers for Roger Federer during a match against Lloyd Harris on Centre Court during the 2019 Championships Wimbledon at the All England Lawn Tennis Club in Wimbledon, England Tuesday, July 2, 2019. (Photo by Billie Weiss/Wimbledon)
July 2, 2019 , Wimbledon, England: Roger Federer hits a volley during a match against Lloyd Harris on Centre Court during the 2019 Championships Wimbledon at the All England Lawn Tennis Club in Wimbledon, England Tuesday, July 2, 2019. (Photo by Billie Weiss/Wimbledon)
July 2, 2019 , Wimbledon, England: Serena Williams hits a forehand during a match against Giulia Gatto-Monticone on Centre Court during the 2019 Championships Wimbledon at the All England Lawn Tennis Club in Wimbledon, England Tuesday, July 2, 2019. (Photo by Billie Weiss/Wimbledon)
Here is some visual work from Day 2 at Wimbledon! The first piece is a quick 60 second video hit on the return of Wimbledon defending Champion, Angelique Kerber. I also shot a few photos of some famous people.
July 4, 2019 bjweiss22 Tagged 2019, Billie Weiss, Billie Weiss Photography, Billie Weiss Photos, Billie Weiss Wimbledon Photos, NO. 1 Court, No. 1 Court Wimbledon, Photo, Roger Federer, Roger Federer Photos, Serena Williams, Serena Williams Photos, Wimbledon, Wimbledon Photos	1 Comment
2017 US OPEN TENNIS CHAMPIONSHIPS PHOTOS: THURSDAY, AUGUST 31, 2017.
August 31, 2017, New York City, NY: Roger Federer walks onto the court before a match against Mikhail Youzhny during the 2017 US Open Tennis Championships at the Billie Jean King National Tennis Center in New York, New York Thursday, August 31, 2017. (Photo by Billie Weiss/US Open Tennis Championships)
August 31, 2017, New York City, NY: Roger Federer reacts during a match against Mikhail Youzhny during the 2017 US Open Tennis Championships at the Billie Jean King National Tennis Center in New York, New York Thursday, August 31, 2017. (Photo by Billie Weiss/US Open Tennis Championships)
August 31, 2017, New York City, NY: Mikhail Youzhny walks onto the court before a match against Roger Federer during the 2017 US Open Tennis Championships at the Billie Jean King National Tennis Center in New York, New York Thursday, August 31, 2017. (Photo by Billie Weiss/US Open Tennis Championships)
August 31, 2017, New York City, NY: Roger Federer and Mikhail Youzhny in action during the 2017 US Open Tennis Championships at the Billie Jean King National Tennis Center in New York, New York Thursday, August 31, 2017. (Photo by Billie Weiss/US Open Tennis Championships)
August 31, 2017, New York City, NY: Roger Federer hits an overhand on match point during a match against Mikhail Youzhny during the 2017 US Open Tennis Championships at the Billie Jean King National Tennis Center in New York, New York Thursday, August 31, 2017. (Photo by Billie Weiss/US Open Tennis Championships)
August 31, 2017, New York City, NY: Mikhail Youzhny walks off the court after losing a match against Roger Federer during the 2017 US Open Tennis Championships at the Billie Jean King National Tennis Center in New York, New York Thursday, August 31, 2017. (Photo by Billie Weiss/US Open Tennis Championships)
August 31, 2017, New York City, NY: Roger Federer reacts after defeating Mikhail Youzhny in five sets during the 2017 US Open Tennis Championships at the Billie Jean King National Tennis Center in New York, New York Thursday, August 31, 2017. (Photo by Billie Weiss/US Open Tennis Championships)
August 31, 2017, New York City, NY: Coco Vandeweghe reacts after defeating Ons Jabeur during the 2017 US Open Tennis Championships at the Billie Jean King National Tennis Center in New York, New York Thursday, August 31, 2017. (Photo by Billie Weiss/US Open Tennis Championships)
August 31, 2017, New York City, NY: Ons Jabeur reacts during a match against Coco Vandeweghe during the 2017 US Open Tennis Championships at the Billie Jean King National Tennis Center in New York, New York Thursday, August 31, 2017. (Photo by Billie Weiss/US Open Tennis Championships)
August 31, 2017, New York City, NY: Coco Vandeweghe in action during a match against Ons Jabeur during the 2017 US Open Tennis Championships at the Billie Jean King National Tennis Center in New York, New York Thursday, August 31, 2017. (Photo by Billie Weiss/US Open Tennis Championships)
August 31, 2017, New York City, NY: Rafael Nadal is introduced to the crowd on Arthur Ashe Stadium before a match against Taro Daniel during the 2017 US Open Tennis Championships at the Billie Jean King National Tennis Center in New York, New York Thursday, August 31, 2017. (Photo by Billie Weiss/US Open Tennis Championships)
August 31, 2017, New York City, NY: Rafael Nadal in action during a match against Taro Daniel during the 2017 US Open Tennis Championships at the Billie Jean King National Tennis Center in New York, New York Thursday, August 31, 2017. (Photo by Billie Weiss/US Open Tennis Championships)
August 31, 2017, New York City, NY: Rafael Nadal reacts during a match against Taro Daniel during the 2017 US Open Tennis Championships at the Billie Jean King National Tennis Center in New York, New York Thursday, August 31, 2017. (Photo by Billie Weiss/US Open Tennis Championships)
August 31, 2017, New York City, NY: Rafael Nadal reacts after defeating Taro Daniel during the 2017 US Open Tennis Championships at the Billie Jean King National Tennis Center in New York, New York Thursday, August 31, 2017. (Photo by Billie Weiss/US Open Tennis Championships)
Here is a gallery from my third and final day of the 2017 US Open Tennis Championships. A big thanks to the USTA and the amazing photo team for including me. It's an honor to be just a small part on a hard working, talented team like this one is.
I'll be sad to miss the rest of the tennis, but excited to be back in Boston for a busy month of September!
September 1, 2017 bjweiss22 Tagged 2017, 2017 US Open Photos, 2017 US Open Tennis, 2017 US Open Tennis Photos, Arthur Ashe Stadium, Arthur Ashe Stadium Photos, Billie Weiss, Billie Weiss Photography, Billie Weiss Photos, Coco Vandeweghe, Coco Vandweghe Photos, Mikhail Youzhny, Mikhail Youzhny Photos, Photo, Photography, Rafael Nadal, Rafael Nadal Photos, Roger Federer, Roger Federer Photos, US Open, US Open Photos, US Open Tennis Championships Photos	Leave a comment
2017 BNP Paribas Open: Sunday, March 20, 2017.
Elena Vesnina in action during the women's final against Svetlana Kuznetsova at the Indian Wells Tennis Garden in Indian Wells, California on Sunday, March 19, 2017. (Photo by Billie Weiss/BNP Paribas Open)
The Tiger Squadron performs a fly over over Stadium 1 before the women's final between Svetlana Kuznetsova and Elena Vesnina at the Indian Wells Tennis Garden in Indian Wells, California on Sunday, March 19, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Svetlana Kuznetsova in action during the women's final against Elena Vesnina at the Indian Wells Tennis Garden in Indian Wells, California on Sunday, March 19, 2017. (Photo by Billie Weiss/BNP Paribas Open)
A general view of stadium one during the women's final between Svetlana Kuznetsova and Elena Vesnina at the Indian Wells Tennis Garden in Indian Wells, California on Sunday, March 19, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Elena Vesnina reacts after winning the women's final against Svetlana Kuznetsova at the Indian Wells Tennis Garden in Indian Wells, California on Sunday, March 19, 2017. (Photo by Billie Weiss/BNP Paribas Open)
at the Indian Wells Tennis Garden in Indian Wells, California on Sunday, March 19, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Roger Federer in action during the men's final against Stan Wawrinka at the Indian Wells Tennis Garden in Indian Wells, California on Sunday, March 19, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Actress Charlize Theron attends the men's final between Roger Federer and Stan Wawrinka at the Indian Wells Tennis Garden in Indian Wells, California on Sunday, March 19, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Roger Federer reacts after winning the men's final against Stan Wawrinka at the Indian Wells Tennis Garden in Indian Wells, California on Sunday, March 19, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Roger Federer holds up the trophy as confetti falls during the trophy presentation after the men's singles final against Stan Wawrinka at the Indian Wells Tennis Garden in Indian Wells, California on Sunday, March 19, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Roger Federer poses for a portrait with the Baccarat Crystal trophy after winning the men's singles final against Stan Wawrinka at the Indian Wells Tennis Garden in Indian Wells, California on Sunday, March 19, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Stan Wawrinka speaks during the trophy presentation after the men's singles final against Roger Federer at the Indian Wells Tennis Garden in Indian Wells, California on Sunday, March 19, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Stan Wawrinka in action during the men's final against Roger Federer at the Indian Wells Tennis Garden in Indian Wells, California on Sunday, March 19, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Roger Federer wears a Swiss flag as he poses for a portrait after winning the men's singles final against Stan Wawrinka at the Indian Wells Tennis Garden in Indian Wells, California on Sunday, March 19, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Here are photos from championship Sunday at this year's BNP Paribas Open. This was the 5th time I've shot this tournament. That's hard to believe. Shooting around the grounds in the 90 plus degree heat has become second nature to me by this point, but with familiarity comes the challenge of making what you shoot look unique and different from years past. It's a good challenge every year, and this go around was just that – a good challenge.
It's not just a challenge creatively, either. 15-plus hour days in the desert sun with no days off is really difficult to do. By the end of this tournament, I was completely spent, both physically and mentally. Luckily, I think pacing is something you learn as you get older. I feel like I've gotten a little better at this over the years, at least.
While the tennis is always amazing in Indian Wells, what keeps me coming back year after year are the people I work with. I'm so lucky to be included each year as part of an incredibly talented, hard working, fun group of photographers, editors, writers, videographers, and social media gurus. Having a team of people like this around you pushes you to be better, and it's amazing to see ideas and concepts come to life through the collaboration among us. Thanks again to everyone on the team – you know who you are!
After a month in Florida for Spring Training, followed immediately by 10 days at this tournament, I'm back in Boston and catching up on rest. But not too much rest. Opening Day is in 11 days!
March 22, 2017 March 22, 2017 bjweiss22 Tagged 2017, 2017 BNP Paribas Open, 2017 BNP Paribas Open Photos, Billie Weiss, Billie Weiss Photography, BNP Paribas Open, BNP Paribas Open Photos, Elena Vesnina, Elena Vesnina Photos, Elena Vesnina Portrait, Indian Wells, Indian Wells Tennis, Indian Wells Tennis Photos, Photo, Photography, Roger Federer, Roger Federer Photos, Roger Federer Portrait, Stan Wawrinka, Stan Wawrinka Photos, Tennis, Tennis Photography	Leave a comment
2017 BNP Paribas Open: Friday, March 17, 2017.
Jack Sock reacts after defeating Kei Nishikori at the Indian Wells Tennis Garden in Indian Wells, California on Friday, March 17, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Roger Federer addresses the crowd after his opponent Nick Kyrgios retired from their upcoming match due to illness at the Indian Wells Tennis Garden in Indian Wells, California on Friday, March 17, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Roger Federer signs autographs after addressing the crowd after his opponent Nick Kyrgios retired from their upcoming match due to illness at the Indian Wells Tennis Garden in Indian Wells, California on Friday, March 17, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Jack Sock in action during a match against Kei Nishikori at the Indian Wells Tennis Garden in Indian Wells, California on Friday, March 17, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Jack Sock reacts during a match against Kei Nishikori at the Indian Wells Tennis Garden in Indian Wells, California on Friday, March 17, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Kristina Mladenovic and Elena Vesnina walk through the tunnel before the semi-final match at the Indian Wells Tennis Garden in Indian Wells, California on Friday, March 17, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Kristina Mladenovic walks through the tunnel before the semi-final match at the Indian Wells Tennis Garden in Indian Wells, California on Friday, March 17, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Elena Vesnina in action during the semi-final match against Kristina Mladenovic at the Indian Wells Tennis Garden in Indian Wells, California on Friday, March 17, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Kristina Mladenovic reacts during the semi-final match against Elena Vesnina at the Indian Wells Tennis Garden in Indian Wells, California on Friday, March 17, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Kristina Mladenovic in action during the semi-final match against Elena Vesnina at the Indian Wells Tennis Garden in Indian Wells, California on Friday, March 17, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Svetlana Kuznetsova reacts after winning the semi-final match against Karolina Pliskova at the Indian Wells Tennis Garden in Indian Wells, California on Friday, March 17, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Elena Vesnina reacts after winning the semi-final match against Kristina Mladenovic at the Indian Wells Tennis Garden in Indian Wells, California on Friday, March 17, 2017. (Photo by Billie Weiss/BNP Paribas Open)
I'm late catching up on tennis from Friday. Here are some photos from a busy day.
March 19, 2017 bjweiss22 Tagged 2017, 2017 BNP Paribas Open, 2017 BNP Paribas Open Photos, Billie Weiss, Billie Weiss Photography, BNP Paribas Open, BNP Paribas Open Photos, Elena Vesnina, Elena Vesnina Photos, Indian Wells, Indian Wells Tennis, Indian Wells Tennis Photos, Jack Sock, Jack Sock Photos, Kristina Mladenovic, Kristina Mladenovic Photos, Photo, Photography, Roger Federer, Roger Federer Photos, Tennis, Tennis Photography	Leave a comment
2017 BNP Paribas Open: Wednesday, March 15, 2017.
Svetlana Kuznetsova in action during a match against Anastasia Pavlyuchenkova at the Indian Wells Tennis Garden in Indian Wells, California on Saturday, March 11, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Svetlana Kuznetsova reacts after defeating Anastasia Pavlyuchenkova at the Indian Wells Tennis Garden in Indian Wells, California on Saturday, March 11, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Nick Kyrgios in action during a match against Novak Djokovic at the Indian Wells Tennis Garden in Indian Wells, California on Saturday, March 11, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Novak Djokovic in action during a match against Nick Kyrgios at the Indian Wells Tennis Garden in Indian Wells, California on Saturday, March 11, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Novak Djokovic reacts during a match against Nick Kyrgios at the Indian Wells Tennis Garden in Indian Wells, California on Saturday, March 11, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Roger Federer warms up before a match against Rafael Nadal at the Indian Wells Tennis Garden in Indian Wells, California on Saturday, March 11, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Nick Kyrgios reacts during a match against Novak Djokovic at the Indian Wells Tennis Garden in Indian Wells, California on Saturday, March 11, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Rafael Nadal in action during a match against Roger Federer at the Indian Wells Tennis Garden in Indian Wells, California on Saturday, March 11, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Rafael Nadal reacts during a match against Roger Federer at the Indian Wells Tennis Garden in Indian Wells, California on Saturday, March 11, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Roger Federer in action during a match against Rafael Nadal at the Indian Wells Tennis Garden in Indian Wells, California on Saturday, March 11, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Roger Federer gestures as he hits tennis balls into the stands after defeating Rafael Nadal at the Indian Wells Tennis Garden in Indian Wells, California on Saturday, March 11, 2017. (Photo by Billie Weiss/BNP Paribas Open)
at the Indian Wells Tennis Garden in Indian Wells, California on Saturday, March 11, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Roger Federer reacts after defeating Rafael Nadal at the Indian Wells Tennis Garden in Indian Wells, California on Saturday, March 11, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Roger Federer waves as he rides away in the golf cart after defeating Rafael Nadal at the Indian Wells Tennis Garden in Indian Wells, California on Saturday, March 11, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Roger Federer signs autographs after defeating Rafael Nadal at the Indian Wells Tennis Garden in Indian Wells, California on Saturday, March 11, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Roger Federer walks through the tunnel after defeating Rafael Nadal at the Indian Wells Tennis Garden in Indian Wells, California on Saturday, March 11, 2017. (Photo by Billie Weiss/BNP Paribas Open)
A fan holds a big head during a match between Roger Federer and Rafael Nadal at the Indian Wells Tennis Garden in Indian Wells, California on Saturday, March 11, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Gael Monfils in action during a match against Dominic Thiem at the Indian Wells Tennis Garden in Indian Wells, California on Saturday, March 11, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Gael Monfils kicks a tennis ball during a match against Dominic Thiem at the Indian Wells Tennis Garden in Indian Wells, California on Saturday, March 11, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Yesterday was another full day of tennis in Indian Wells. Roger Federer wiped Rafael Nadal off the court. It's always a fun match up to shoot.
March 16, 2017 March 16, 2017 bjweiss22 Tagged 2017, 2017 BNP Paribas Open, 2017 BNP Paribas Open Photos, Billie Weiss, Billie Weiss Photography, BNP Paribas Open, BNP Paribas Open Photos, Gael Monfils, Gael Monfils Photos, Indian Wells, Indian Wells Tennis, Indian Wells Tennis Photos, Novak Djokovic, Novak Djokovic Photos, Photo, Photography, Rafael Nadal, Rafael Nadal Photos, Roger Federer, Roger Federer Photos, Tennis, Tennis Photography	Leave a comment
2017 BNP Paribas Open: Tuesday, March 14, 2017.
Rafael Nadal reacts after defeating Fernando Verdasco at the Indian Wells Tennis Garden in Indian Wells, California on Tuesday, March 14, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Donald Young reacts after defeating Lucas Pouille at the Indian Wells Tennis Garden in Indian Wells, California on Tuesday, March 14, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Lucas Pouille in action during a match against Donald Young at the Indian Wells Tennis Garden in Indian Wells, California on Tuesday, March 14, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Rafael Nadal practices before a match at the Indian Wells Tennis Garden in Indian Wells, California on Tuesday, March 14, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Venus Williams in action during a match against Shuai Peng at the Indian Wells Tennis Garden in Indian Wells, California on Tuesday, March 14, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Roger Federer walks out of the tunnel before a match against Steve Johnson at the Indian Wells Tennis Garden in Indian Wells, California on Tuesday, March 14, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Venus Williams reacts after defeating Shuai Peng at the Indian Wells Tennis Garden in Indian Wells, California on Tuesday, March 14, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Roger Federer in action during a match against Steve Johnson at the Indian Wells Tennis Garden in Indian Wells, California on Tuesday, March 14, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Elena Vesnina in action during a match against Angelique Kerberat the Indian Wells Tennis Garden in Indian Wells, California on Tuesday, March 14, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Grigor Dimitrov in action during a match against Jack Sock at the Indian Wells Tennis Garden in Indian Wells, California on Tuesday, March 14, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Elena Vesnina reacts after defeating Angelique Kerber during a match at the Indian Wells Tennis Garden in Indian Wells, California on Tuesday, March 14, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Jack Sock reacts after defeating Grigor Dimitrov at the Indian Wells Tennis Garden in Indian Wells, California on Tuesday, March 14, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Another big day of tennis yesterday. Here are a few favorites from the day.
March 15, 2017 bjweiss22 Tagged 2017, 2017 BNP Paribas Open, 2017 BNP Paribas Open Photos, Billie Weiss, Billie Weiss Photography, BNP Paribas Open, BNP Paribas Open Photos, Donald Young, Donald Young Photos, Elena Vesnina, Elena Vesnina Photos, Indian Wells, Indian Wells Tennis, Indian Wells Tennis Photos, Jack Sock, Jack Sock Photos, Photo, Photography, Rafael Nadal, Rafael Nadal Photos, Roger Federer, Roger Federer Photos, Tennis, Tennis Photography, Venus Williams, Venus Williams Photos	Leave a comment
Rafael Nadal in action during a match against Guido Pella during the 2017 BNP Paribas Open at the Indian Wells Tennis Garden in Indian Wells, California on Sunday, March 12, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Stan Wawrinka signs autographs during the 2017 BNP Paribas Open at the Indian Wells Tennis Garden in Indian Wells, California on Sunday, March 12, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Fans attend the 2017 BNP Paribas Open at the Indian Wells Tennis Garden in Indian Wells, California on Sunday, March 12, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Caroline Wozniacki walks off the practice court during the 2017 BNP Paribas Open at the Indian Wells Tennis Garden in Indian Wells, California on Sunday, March 12, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Rafael Nadal reacts after defeating Guido Pella during the 2017 BNP Paribas Open at the Indian Wells Tennis Garden in Indian Wells, California on Sunday, March 12, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Rafael Nadal waves as he walks off court after defeating Guido Pella during the 2017 BNP Paribas Open at the Indian Wells Tennis Garden in Indian Wells, California on Sunday, March 12, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Juan Martin Del Potro in action during a match against Federico Delbonis during the 2017 BNP Paribas Open at the Indian Wells Tennis Garden in Indian Wells, California on Sunday, March 12, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Juan Martin Del Potro walks out of the tunnel before a match against Federico Delbonis during the 2017 BNP Paribas Open at the Indian Wells Tennis Garden in Indian Wells, California on Sunday, March 12, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Juan Martin Del Potro reacts after hitting a between the legs shot during a match against Federico Delbonis during the 2017 BNP Paribas Open at the Indian Wells Tennis Garden in Indian Wells, California on Sunday, March 12, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Juan Martin Del Potro reacts after defeating Federico Delbonis during the 2017 BNP Paribas Open at the Indian Wells Tennis Garden in Indian Wells, California on Sunday, March 12, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Roger Federer in action during a match against Stephane Robert during the 2017 BNP Paribas Open at the Indian Wells Tennis Garden in Indian Wells, California on Sunday, March 12, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Roger Federer walks through the tunnel before a match against Stephane Robert during the 2017 BNP Paribas Open at the Indian Wells Tennis Garden in Indian Wells, California on Sunday, March 12, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Fans cheer after a match between Roger Federer and Stephane Robert during the 2017 BNP Paribas Open at the Indian Wells Tennis Garden in Indian Wells, California on Sunday, March 12, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Roger Federer reacts after defeating Stephane Robert during the 2017 BNP Paribas Open at the Indian Wells Tennis Garden in Indian Wells, California on Sunday, March 12, 2017. (Photo by Billie Weiss/BNP Paribas Open)
Here are some images from my third day out here at Indian Wells. A decent, very hot, day of shooting.
March 13, 2017 bjweiss22 Tagged 2017, 2017 BNP Paribas Open, 2017 BNP Paribas Open Photos, Billie Weiss, Billie Weiss Photography, BNP Paribas Open, BNP Paribas Open Photos, Indian Wells, Indian Wells Tennis, Indian Wells Tennis Photos, Juan Martin Del Potro, Juan Martin Del Potro Photos, Photo, Photography, Rafael Nadal, Rafael Nadal Photos, Roger Federer, Roger Federer Photos, Tennis, Tennis Photography	Leave a comment
2015 BNP Paribas Open – Day 15.
"The 2015 BNP Paribas Open Women's Singles Final between Simona Halep and Jelena Jankovic in Indian Wells, California on Sunday, March 22, 2015."
"Simona Halep reacts after defeating Jelena Jankovic in the 2015 BNP Paribas Open Women's Singles Final in Indian Wells, California on Sunday, March 22, 2015."
"Trophy Ceremony after the BNP Paribas Open Women's Singles Final between Simona Halep and Jelena Jankovic in Indian Wells, California on Sunday, March 22, 2015."
"The 2015 BNP Paribas Open Men's Singles Final between Novak Djokovic and Roger Federer in Indian Wells, California on Sunday, March 22, 2015."
"Novak Djokovic reacts after winning the 2015 BNP Paribas Open Men's Singles Final against Roger Federer in Indian Wells, California on Sunday, March 22, 2015."
"Novak Djokovic during the 2015 BNP Paribas Open Men's Singles trophy ceremony in Indian Wells, California on Sunday, March 22, 2015."
"Novak Djokovic poses with the Serbian flag following his victory in the Men's Singles Final of the 2015 BNP Paribas Open in Indian Wells, California on Sunday, March 22, 2015."
Above is a gallery of photos from both the men's and women's singles finals matches at the 2015 BNP Paribas Open. I'm a bit late in posting these, but it's been a crazy few days of traveling and getting back into the swing of things in Boston.
Sunday made for an amazing day of tennis, with two back and forth, three set matches. In the end, Simona Halep and Novak Djokovic were able to pull off wins against Jelena Jankovic and Roger Federer. These are some of my favorites from the day.
And with that, the tournament comes to a close! Indian Wells has a special place in my heart, and just like years before, my experience working for the tournament web and social media team was incredible. It was long days in 90 plus degree heat, tired legs and sore shoulders. But it was also amazing tennis, unparalleled access, and genuinely great people to work with.
I believe that any place or experience is only as good as the people it's shared with, and the team of writers, photographers, editors, social media specialists, and public relations experts that I am lucky to be a part of is second to none. I owe many thanks to each person on our team. They are all talented, creative, hard working, and fun to be around.
I hope I'm able to continue working in tennis in the future!
March 26, 2015 bjweiss22 Tagged 2015, 2015 BNP Paribas Open Finals, 2015 BNP Paribas Open Finals Photos, Billie Weiss, Billie Weiss Photography, Billie Weiss Tennis, BNP Paribas Open, BNP Paribas Open 2015, BNP Paribas Open 2015 Photos, BNP Paribas Open Photos, Indian Wells, Indian Wells 2015 Photos, Indian Wells Photos, Indian Wells Tennis Garden, Indian Wells Tennis Garden Photos, Jelena Jankovic, Jelena Jankovic Indian Wells Photos, Jelena Jankovic Photos, Novak Djokovic, Novak Djokovic Indian Wells Photos, Novak Djokovic Photos, Photo, Photography, Roger Federer, Roger Federer Indian Wells PHotos, Roger Federer Photos, Simona Halep, Simona Halep Indian Wells Photos, Simona Halep Photos, Tennis	Leave a comment
"A semifinal match between Novak Djokovic and Andy Murray on Stadium 1 at the 2015 BNP Paribas Open in Indian Wells, California on Saturday, March 21, 2015."
"A semifinal match between Roger Federer and Milos Raonic on Stadium 1 at the 2015 BNP Paribas Open in Indian Wells, California on Saturday, March 21, 2015."
"Vasek Pospisil and Jack Sock defeat Simone Bolelli and Fabio Fognini to win the Menís Doubles Championship on Stadium 1 at the 2015 BNP Paribas Open in Indian Wells, California on Saturday, March 21, 2015."
"Vasek Pospisil and Jack Sock defeat Simone Bolelli and Fabio Fognini to win the Men's Doubles Championship on Stadium 1 at the 2015 BNP Paribas Open in Indian Wells, California on Saturday, March 21, 2015."
"Martina Hingis and Sania Mirza defeat Ekaterina Makarova and Elena Vesnina to win the Womenís Doubles Championship on Stadium 1 at the 2015 BNP Paribas Open in Indian Wells, California on Saturday, March 21, 2015."
Here are photos from the men's semi-finals and the men's and women's doubles finals. Not a lot of time to post so this is a rough cut!
March 22, 2015 bjweiss22 Tagged 2015, Andy Murray, Andy Murray Indian Wells Photos, Andy Murray Photos, Billie Weiss, Billie Weiss Photography, Billie Weiss Tennis, BNP Paribas Open, BNP Paribas Open 2015, BNP Paribas Open 2015 Photos, BNP Paribas Open Photos, Indian Wells, Indian Wells 2015 Photos, Indian Wells Photos, Indian Wells Tennis Garden, Indian Wells Tennis Garden Photos, Jack Sock, Jack Sock Photos, Novak Djokovic, Novak Djokovic Indian Wells Photos, Novak Djokovic Photos, Photo, Photography, Roger Federer, Roger Federer Indian Wells PHotos, Roger Federer Photos, Tennis, Vasek Pospisil, Vasek Pospisil Indian Wells Photos, Vasek Pospisil Photos	Leave a comment


Hey ! I would like to request a showing of 5523 E 107th Street. Let me know what times you are available. Thank you!
This listing is courtesy of the listing agent Jim Bigelow (#jbigelow), with the office Coldwell Banker Select.
All data for this listing was last updated on April 17, 2019 at 11:34AM.


text:
PV project exchange
QMC bags fresh Amtronics order for solar cell production equipment
The $500k order follows the delivery of two high-volume quantum-dot production systems—valued at $1 million—to support roll-to-roll printing of thin-film solar cells at Assam facility.
July 26, 2019 Uma Gupta
Aerial view of Assam Tech City, where the Qamronics facility is coming up.
Quantum Materials Corp.
U.S.-based Quantum Materials Corp (QMC)—a cadmium-free quantum-dot and nanomaterials manufacturer—has received an additional $500k equipment order from construction and electronics business Amtronics to support quantum-dot based solar cell printing through joint venture Qamronics India. The equipment order is scheduled for delivery during the fourth quarter of this year.
Formed by Amtronics and the state-owned Assam Electronics Development Corp Ltd (Amtron), the Qamronics quantum-dot development/production facility is part of the Tech City project in Assam, which is currently under construction with a target completion date of November 2019.
In June, QMC had won Amtronics order totaling $1 million for two high-volume quantum-dot production systems. The order was secured with a letter of credit issued by Amtron.
"The two systems are already in transit for delivery to the Assam facility," according to a press statement by QMC.
"The shipment of these two units clears the payment obligation for the first $700,000 of the sale amount, which is being satisfied by a Letter of Credit established by Amtron to fund this project. Once the equipment have been installed, an additional $150,000 will be eligible for transfer to Quantum Materials Corp., with the final $150,000 eligible for payment to Quantum Materials once the units have been certified for production at the facility"—added the press statement.
QMC CEO Stephen B. Squires commented, "Our team is doing a fantastic job of manufacturing and delivering the highly specialized quantum-dot production equipment required to fulfill our licensees' specifications for this forward-thinking project. It is very exciting to see the project footprint increase from 20,000 to 75,000 sq. ft, enabling us to expand our mission of developing infrastructure to support roll-to-roll printing of next-generation quantum-dot based thin-film solar cells."
In addition to thin-film solar cells, the Assam factory will also develop flat panel displays and solid-state LED lighting.
Amtronics India CEO Dr Tony Balchin added, "Due to the substantial increase in size of the facility, we are now including a multi-story quantum-dot laboratory and factory complex incorporating the latest engineering and environmental technologies. Design work is nearly completed and we have appointed a local architectural/engineering company as the 'Architect of Record' to prepare conceptual designs as well as execute detailed engineering plans of the project in accordance with all local regulations and building codes."
Uma Gupta
Based in New Delhi, Uma reports on the latest PV market trends and projects in India. After gaining an MSc Physics (Electronics) and an MBA, she has gone on to accrue over a decade of experience in technology journalism.
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The Low-Down on Digital Pianos – We look at the top 5 best sellers!
Digital pianos are an amazing new take on an old instrument. Houses these days just haven't got the room for a large, even if beautifully made, grand piano. The sound of a piano is certainly not outdated though, and that's where these digital devices come in – all the musical ability and versatility of the piano without being immobile and expensive.
Digital pianos come in a large variety of types, and you need to decide what would work best for you, but generally the upright stand pianos, constructed to mimic an actual upright piano, are the most popular.
The tone, keyboard sensitivity, hammer action, and acoustics vary from model to model, as do the piano's effects and other digital abilities, so it's worth taking your time and trying out a few before you buy.
This looks and feels like an impressive piece of kit. It's solidly built, comes with excellent instructions, has a huge range of features, and is super value.
This is a nice sized keyboard, and the weighted keys make a real difference to the experience of playing it– they feel more like a traditional piano, and spring back rapidly. The sound quality is impressive, and there are a huge range of settings and effects to play with.
Alesis have made a great addition to the digital piano market with this decently priced keyboard.
Despite what our neighbors think, this piano could do with being a little louder; the volume doesn't go quite as high as we'd like.
A wonderful modern musical instrument that will be a joy to play for novices and seasoned pianists alike. The settings are fun to experiment with, or you can keep it as a traditional piano. The sound is beautiful, albeit a little on the quieter side. Overall we're very happy.
Yamaha have cornered the market in digital pianos, and on unpacking this one, it's easy to see why – it's sturdy, well made, and has brilliantly easy to follow instructions. Design wise, it's nice and slim, and not too heavy. So far, it's looking good!
This model is great fun, allowing you to really play around with mixing voices, including the pre-programed tones and acoustics, while the weighted keys make it feel very professional. All in all, very impressive.
After playing around with this, we found that, in order to use the 'sustain' pedal, it needs to be plugged in before turning on the keyboard. If you do otherwise, it doesn't 'sustain' at all!
This lived up to everything I'd expected from Yamaha. With the amount of options available, and the weighted keys, this piano could be used by a professional pianist, and comes at a fantastic online price!
After arriving in several boxes, this was easy to set up, thanks to simple to follow instructions. We were happily practicing our menuets in no time.
The tone of this piano is perfect. Hearing it from afar, you wouldn't know it was digital, and for us that is crucial. Together with ultra sensitive pedals, nicely weighted and textured keys, and it arriving with everything we need to play, is what makes this one of the best on the market!
The bench that is part of the set is not adjustable, and thus it was a little bit tall for some of our team to comfortably reach the pedals.
We loved this smart piano. Sound-wise you wouldn't know it wasn't the real thing, and after a month of enthusiastic use, it remains in perfect condition. This is a piano that'll cause you to smile when you play!
This is a great looking piece of kit – RockJam have really gone to town with this. Sturdy enough to withstand the rigors of even the most enthusiastic hammering, the full size keyboard, complete with music stand, LCD screen and stool is hugely versatile, both for beginners and experienced players alike.
The interface is very user friendly, and with tutorials, songs, and rhythms all preprogrammed, once we'd unpacked it, got the stand ready, and taken time out for a coffee, we were ready to play. Even the most novice among us was able to follow the tutorials, sounding great and full of confidence very quickly.
We love the cross-platform app, which is regularly updated with new tunes and lessons.
The RockJam is quite heavy if you want to carry it around regularly. But this isn't a deal breaker for us.
The RockJam makes learning and playing music simple. For adults and children, the tutorials are easy to follow, and progressive, setting you off on your own creations with confidence and skill. Highly recommend.
Finally, the Yamaha Digital Grand Piano.
If you're looking for the ultimate digital piano, you've found it. It just doesn't get much better than this.
As you'd expect from a leading brand, it's superb quality, asily put together, looks much more expensive than it is, and comes with lots of extras.
The pitch, the tone, the voices – all perfect! The keys are the right weight, and you can get carried away playing Beethoven, without striking two keys by accident (well, almost). We're very impressed by this, and it could take someone with talent from beginner to concert without changing the keyboard!
Our only complaint is that the number of settings could be a little daunting – there are so many options to choose from, but we found one that we liked and stuck with it.
Also the bench was ever so slightly too tall for some of us to reach the pedals without stretching – not too much of a problem, but it did disturb the flow sometimes.
This Yamaha Grand is an incredibly good piano – very versatile and with excellent sound quality. Even if you had the space and budget for a real baby grand, I would recommend this baby every time.
If you enjoy reading this article then check out some of our other hand selected recommendations!


text:
#region License

#endregion

using System.Messaging;

namespace Spring.Messaging.Core
{
    /// <summary>
    /// Utility class to recreate message queues if they do not exist.
    /// </summary>
    /// <author>Mark Pollack</author>
    public class MessageQueueUtils
    {
        public static void RecreateMessageQueue(string path, bool transactional)
        {
            bool defaultCacheEnabled = MessageQueue.EnableConnectionCache;
            MessageQueue.ClearConnectionCache();
            MessageQueue.EnableConnectionCache = false;
            if (MessageQueue.Exists(path))
            {
                // TODO (EE): delete/create doesn't work for some reason
                //                MessageQueue.Delete(path);
                //                queue = MessageQueue.Create(path, transactional);
                using (MessageQueue queue = new MessageQueue(path))
                {
                    queue.Purge();
                }
            }
            else
            {
                /*
                 * MSDN docs indicate that calls to the static .Create() method should include
                 *   an explicit call to .Dispose() b/c unmanaged resources are involved
                 * Here this req'ment is handled implicitly with the using() statement
                 *  even though the empty using() block seems odd at first glance b/c it
                 *  encloses a static method call
                 */
                using (MessageQueue.Create(path, transactional))
                {

                }
            }
            MessageQueue.ClearConnectionCache();
            MessageQueue.EnableConnectionCache = defaultCacheEnabled; // set to default
        }
    }

}

redpajama_set_name: RedPajamaGithub


text:
Andrew Lorinser
Michigan Politics | Andrew Lorinser
Community Benefits Agreement
Labor / Trades / Nurses Union / CBAs
Shoreline Development
Labor Federation endorses Lorinser for City Commission
June 24, 2019 andrewlorinser
MARQUETTE, Mich. — After candidate screening with the Marquette-Alger Community Labor Council a motion was made recommending the endorsement of Andrew Lorinser by the UP Regional Labor Federation, AFL-CIO. This motion was in turn passed unanimously by the Committee on Political Education, securing Lorinser's endorsement.
"It is my hope that our endorsement will play a role in securing victory come August and November," says UPRLF Field Coordinator, Alex Gustafson. "Working families need allies in city government and we believe strongly that as a friend of labor, Andrew will be one."
Beyond several hundred personal endorsements, Lorinser did not seek out many organizational endorsements for his primary candidacy in the 2019 race for Marquette City Commission. One organization important to him was the Upper Peninsula Regional Labor Federation (UPRLF).
The UPRLF aims to improve the lives of working families – to bring economic justice to the workplace and social justice to our region. It is an organization of U.P. labor unions representing AFL-CIO affiliates with over 10,000 union members. Affiliates include AFGE, AFSCME, AFT, APWU, BAC, CWA, IAFF, IAMAW, IBEW, IBT, IRON, IUOE, IUPAT, LIUNA, UBC, MNA, SMWIA, TEAMSTERS. UA, UAW, UBC, and USW.
The organization is one of nearly 500 state and local labor councils of the AFL-CIO and are the heart of the labor movement. UPRFL are democratically elected bodies dedicated to represent the interests of working people at the state and local level.
UPRLF mobilizes members and community partners to advocate for social and economic justice and strive daily to vanquish oppression and make our communities better for all people—regardless of race, color, gender, religion, age, sexual orientation, or ethnic or national origin.
"These are values I share, which I hope to translate to policies and representation on City Commission," says Lorinser. "From the beginning of my campaign I've set forth initiatives to celebrate and advocate for cohesive balance between city-development and respect for the rights of the hard working groups that build it, those who care for its people, and the environment upon which it's sustained. UPRFL and I share this goal."
"I want to advocate for the rights of workers, and make it easier for local business and city developers to employ an eager and skilled labor force."
A major policy Lorinser hopes to bring forth to City Commission is the implementation of Community Benefits Agreements, or a Community Benefits Ordinance for all major development projects.
"We need to ensure projects are benefiting the community, employing a local labor force, and are built in more agreeable locations," says Lorinser. "We don't have a CBA right now, so the needs of residents are not being met. If so honored to be elected, I'll get CBAs to a vote."
"I want to extend my gratitude to the organization for their endorsement and reiterate my commitment to issues that affect working families who build and sustain our wonderful micropolis. With me, workers have an ally."
From UPRLF Executive Board
Rich Helgren
Lucas Bradshaw
Andy Schwartz
Tony Alessandrini
Tony Ghiringhelli
Brandon Stromberg
Tony Rossi
Dear Candidate Lorinser,
I am pleased to inform you that the U.P. Regional Labor Federation, AFL-
CIO has endorsed your candidacy for Marquette City Commission.
This endorsement acknowledges your interests in the issues which affect workers, your dedication to the values embodied by the labor movement, and your commitment to addressing the needs of all the hard-working men and women in our community… Best wishes, and good luck on the campaign trail!
Michael Thibault
← What could a Community Benefits Agreement do for Marquette?
Remembering a local political mentor – In her words →
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