text:
Andrea Marie Jenkyns (born 16 June 1974) is a British politician serving as Deputy Chairwoman of the European Research Group (ERG) since 2019. She was first elected as the Conservative Member of Parliament for Morley and Outwood in West Yorkshire at the 2015 general election, defeating Shadow Chancellor Ed Balls. She was an advocate for the Eurosceptic organisation Leave Means Leave. She was a strong critic of Theresa May during her leadership of the Conservative Party due to her handling of Brexit. Jenkyns served as Parliamentary Under-Secretary of State for Skills from July to October 2022, when she was sacked by new Prime Minister Rishi Sunak.

Early life and career
Jenkyns was born in Beverley, Humberside. After leaving school at 16, she worked at Greggs bakery. When she was 18, Jenkyns' father sent her photo off to a beauty pageant and she got into the final for Miss UK. Her employment history has included being a music tutor in a secondary school and an executive with a management training company. In her late thirties, Jenkyns studied for a degree in Economics from the Open University and for one in International Relations from the University of Lincoln.

She is a former Lincolnshire County Councillor for Boston North West, having defeated the British National Party in a closely run election winning by only 14 votes. Having won the seat in 2009, she lost it to the UK Independence Party (UKIP) candidate at the following council elections in 2013.

Parliamentary career
Following an open primary in 2013, Jenkyns was selected to contest the Morley and Outwood parliamentary seat as the Conservative candidate. In the 2015 general election, she was elected with a slim majority of 422 votes, unseating Shadow Chancellor of the Exchequer Ed Balls in the process. From July 2015, she sat on the Health Select Committee.

Jenkyns supported Brexit in the 2016 EU membership referendum and was a member of the Exiting the European Union Select Committee from 2016 to 2019. Jenkyns stated that she was willing to vote against the Government if it brought forward to the House of Commons the Chequers proposals on Brexit.

In the 2017 general election, Jenkyns increased her vote share by 11.8%, though only increased her majority to 2,104 as Labour's vote share also increased. Both were helped by the lack of a UKIP candidate in her constituency.

Jenkyns is a Trustee and the Regional Representative (Voluntary) for the charity MRSA Action UK, having joined following the death of her father from the superbug MRSA.

In May 2018, Jenkyns quit her role as a PPS in the Ministry of Housing, Communities and Local Government in order to focus on fighting for Brexit.

In July 2018, after David Davis resigned from the Cabinet, Jenkyns called for the Prime Minister Theresa May to be replaced, saying: "Theresa May's premiership is over." She called on the Prime Minister to return to her Lancaster House speech, stating "Prime Ministers keep their jobs when they keep their promises".

She submitted a formal letter to the 1922 Committee requesting a vote of confidence in Theresa May as leader of the Conservative Party; letters from 48 MPs were at that time required to trigger a vote of confidence. Following this, Iain Dale put Andrea Jenkyns on his Top 100 Most Influential Conservatives of 2018 List, that he produces annually.

Jenkyns gained media attention in January 2019 by erroneously stating that Kenya exports flowers to the EU under WTO terms. In May 2019, Jenkyns received further media attention for her appearance on the BBC's Politics Live show, as she was unable to name any countries that trade solely with the EU using World Trade Organization (WTO) terms.
In 2019, Jenkyns received a campaign donation declared (by Jenkyns) at £2,000 from the Brexit advocate and Leave.EU funder Arron Banks. Banks was barred from membership of the Conservative Party at the time, on the grounds that he had advocated entryism.
Jenkyns has received a number of death threats, largely as a result of her stance on Brexit. In October 2019 she discovered graffiti on the wall of her office calling for her to kill herself. In the summer of 2019, a person was taken to court for threatening to "rip" her face off. In 2018, she received a threatening and sexually explicit email calling for her to be cut with barbed wire and die.

Jenkyns is opposed to Britain's sugary drink tax, arguing instead for "better education, better labelling [and] parental responsibility".

Jenkyns held her seat at the 2019 general election with an increased majority. Jenkyns experienced a considerable amount of abuse and intimidation during the campaign. After the election, she was elected Vice-Chair of the European Research Group, replacing Steve Baker, who became the Chair.

In February 2020, Jenkyns defended her decision to provide a character reference for the court case of a Conservative Party activist who made violent threats to Labour MP Yvette Cooper and was subsequently jailed for nine weeks. The statement described the activist as a "decent and honest person whose heart is in the right place". Jenkyns said that the activist had mental health issues and she wanted his emotional and mental well-being to be taken into consideration as part of the judicial process.

On 17 September 2021, Jenkyns was appointed an Assistant Government Whip in the second cabinet reshuffle of the second Johnson ministry.

In July 2022, Jenkyns was appointed Parliamentary Under-Secretary of State at the Department for Education. On the way to attending Boris Johnson's resignation speech in Downing Street, Jenkyns was filmed making a "middle finger" gesture at protesters. Jenkyns said she made the gesture after being provoked by a "baying mob", stating she had received "huge amounts of abuse from some of the people who were there over the years". She said she should have shown more composure "but is only human". Her gesture was criticised by teaching representatives and by Conservative MPs Mark Spencer and George Freeman. On 12 July 2022, her portfolio was confirmed as Parliamentary Under-Secretary of State for Skills, Further and Higher Education. She was reappointed by Liz Truss.

Personal life
Jenkyns lives in Gildersome, West Yorkshire, and London; the latter for her Parliamentary duties where she lives with her husband, fellow Conservative MP Jack Lopresti, and her son, who was born in 2017 and named after her late father. She married Lopresti, the MP for Filton and Bradley Stoke in Bristol, in St Mary Undercroft in the Palace of Westminster on 22 December 2017, two years after it had been reported that she was in a relationship with him while he was still married to his first wife.

Jenkyns suffers from fibromyalgia and glossopharyngeal neuralgia which cause bouts of debilitating pain.

Jenkyns is a vegetarian and supports improvement of animal rights. She also supports keeping the ban on fox hunting. In 2015, her dogs Lady and Godiva won top prize in the Westminster Dog of the Year show.

Jenkyns is also a soprano singer.

Notes

References

External links

1974 births
21st-century British women politicians
21st-century English women singers
21st-century English singers
Living people
Alumni of the University of Lincoln
British Eurosceptics
Conservative Party (UK) MPs for English constituencies
English animal rights activists
English operatic sopranos
English women singer-songwriters
Female members of the Parliament of the United Kingdom for English constituencies
Opera crossover singers
People from Beverley
People from Lincolnshire
Politicians from Yorkshire
Singers with a four-octave vocal range
UK MPs 2015–2017
UK MPs 2017–2019
UK MPs 2019–present
Spouses of British politicians

redpajama_set_name: RedPajamaWikipedia


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News — Jeffrey Lieberman M.D.
CBS This Morning – Medical Expert Weighs in on Robin Williams' Struggle with Depression, Substance Abuse. Actor Suffered from Depression & Substance Abuse. With Charlie Rose, Gayle King and Norah O'Donnell.
CBS This Morning / Morning Rounds - State of Mind. New Book Examines History & Future of Psychiatry. With Charlie Rose, Gayle King and Norah O'Donnell.


text:
16.5: Other Oxygen-Containing Functional Groups
[ "article:topic", "carboxylic acids", "acid", "ether", "aldehyde", "carbonyl group", "ester", "ketone", "carbonyl", "showtoc:no", "carboxylate anion", "license:ccbyncsa" ]
Book: Beginning Chemistry (Ball)
16: Organic Chemistry
Learning Objective
Identify the aldehyde, ketone, acid, ester, and ether functional groups.
There are other functional groups that contain O atoms. Before we introduce them, we define the carbonyl group, which is formed when an O atom and a C atom are joined by a double bond:
The other two bonds on the C atom are attached to other atoms. It is the identities of these other atoms that define what specific type of compound an organic molecule is.
If one bond of the carbonyl group is made to an H atom, then the molecule is classified as an aldehyde (If there are two H atoms, there is only 1 C atom.) When naming aldehydes, the main chain of C atoms must include the carbon in the carbonyl group, which is numbered as position 1 in the carbon chain. The parent name of the hydrocarbon is used, but the suffix -al is appended. (Do not confuse -al with -ol, which is the suffix used for alcohols.) So we have
Methanal has a common name with which you may be familiar: formaldehyde. The main thing to note about aldehydes is that the carbonyl group is at the end of a carbon chain.
A carbonyl group in the middle of a carbon chain implies that both remaining bonds of the carbonyl group are made to C atoms. This type of molecule is called a ketone. Despite the fact that aldehydes and ketones have the same carbonyl group, they have different chemical and physical properties and are properly grouped as two different types of compounds. The smallest ketone has three C atoms in it. When naming a ketone, we take the name of the parent hydrocarbon and change the suffix to -one:
The common name for propanone is acetone. With larger ketones, we must use a number to indicate the position of the carbonyl group, much like a number is used with alkenes and alkynes:
There is another way to name ketones: name the alkyl groups that are attached to the carbonyl group and add the word ketone to the name. So propanone can also be called dimethyl ketone, while 2-butanone is called methyl ethyl ketone.
Draw the structure of 2-pentanone.
This molecule has five C atoms in a chain, with the carbonyl group on the second C atom. Its structure is as follows:
Exercise \(\PageIndex{1}\)
The combination of a carbonyl functional group and an OH group makes the carboxyl group.
Molecules with a carboxyl group are called carboxylic acids. As with aldehydes, the functional group in carboxylic acids is at the end of a carbon chain. Also as with aldehydes, the C atom in the functional group is counted as one of the C atoms that defines the parent hydrocarbon name. To name carboxylic acids, the parent name of the hydrocarbon is used, but the suffix -oic acid is added:
Methanoic acid and ethanoic acid are also called formic acid and acetic acid, respectively. Formic acid is the compound that makes certain ant bites sting, while acetic acid is the active substance in vinegar.
How acidic are carboxylic acids? It turns out that they are not very acidic. No carboxylic acid is on the list of strong acids (Table 12.4.1). This means that all carboxylic acids are weak acids. A 1 M solution of formic acid is only about 1.3% dissociated into H+ ions and formate ions, while a similar solution of acetic acid is ionized by about only 0.4%. Some carboxylic acids are stronger-for example, trichloroacetic acid is about 45% dissociated in aqueous solution. But no carboxylic acid approaches the 100% dissociation amount required by the definition of a strong acid.
As their name suggests, however, carboxylic acids do act like acids in the presence of bases. The H atom in the carboxyl group comes off as the H+ ion, leaving a carboxylate anion:
Carboxylate ions are named from the acid name: the -oic acid is replaced with -oate to name the ion.
Example \(\PageIndex{2}\):
Complete the chemical reaction. Can you name the carboxylate ion formed?
The OH– ion removes the H atom that is part of the carboxyl group:
The carboxylate ion, which has the condensed structural formula CH3CO2−, is the ethanoate ion, but it is commonly called the acetate ion.
The anion is the methanoate ion, which is commonly called the formate ion.
One reaction to consider is that of a carboxylic acid and an alcohol. When combined under the proper conditions, a water molecule will be removed, and the remaining pieces will combine to form a new functional group- the ester functional group:
Note how the acid molecule contributes one alkyl side (represented by R), while the alcohol contributes the other side (represented by R′). Esters are named using the alkyl group name from the alcohol plus the carboxylate name from the acid-for example, the molecule
is called methyl propanoate.
Chemistry Is Everywhere: Esters, Fragrances, and Flavorings
Esters are very interesting compounds, in part because many have very pleasant odors and flavors. (Remember, never taste anything in the chemistry lab!) Many esters occur naturally and contribute to the odor of flowers and the taste of fruits. Other esters are synthesized industrially and are added to food products to improve their smell or taste; it is likely that if you eat a product whose ingredients include artificial flavorings, those flavorings are esters. Here are some esters and their uses, thanks to their odors, flavors, or both:
Tastes/Smells Like
allyl hexanoate pineapple isobutyl formate raspberry
benzyl acetate pear isobutyl acetate pear
butyl butanoate pineapple methyl phenylacetate honey
ethyl butanoate banana nonyl caprylate orange
ethyl hexanoate pineapple pentyl acetate apple
ethyl heptanoate apricot propyl ethanoate pear
ethyl pentanoate apple propyl isobutyrate rum
Finally, the ether functional group is an O atom that is bonded to two organic groups: R-O-R′
The two R groups may be the same or different. Naming ethers is like the alternate way of naming ketones. In this case, the R groups are named sequentially, and the word ether is appended. The molecule CH3OCH3 is dimethyl ether, while CH3OCH2CH3 is methyl ethyl ether. Diethyl ether, another ether, was once used as an anesthetic, but its flammability and toxicity caused it to fall out of favor. Smaller ether molecules that are liquids at room temperature are common solvents for organic chemical reactions.
Aldehydes, ketones, carboxylic acids, esters, and ethers have oxygen-containing functional groups.
Name a similarity between the functional groups found in aldehydes and ketones. Can you name a difference between them?
Explain how a carboxylic acid is used to make an ester.
Name each molecule.
Give an alternate but acceptable name to the molecule in Exercise 3b.
Complete this chemical reaction.
The drug known as aspirin has this molecular structure: Identify the functional group(s) in this molecule.
The drug known as naproxen sodium is the sodium salt of this molecule: (The extra H atoms are omitted for clarity.) Identify the functional group(s) in this molecule.
Identify the ester made by reacting these molecules.
They both have a carbonyl group, but an aldehyde has the carbonyl group at the end of a carbon chain, and a ketone has the carbonyl group in the middle.
propanal
2-butanone
3-methylbutanoic acid
ethyl propionate
ethyl propyl ether
ethyl methyl ketone
H2O + KCH3CH2CO2
acid, ester, and aromatic (benzene ring)
propyl propionate
16.4: Alkyl Halides and Alcohols
16.6: Other Functional Groups
CC BY-NC-SA
carbonyl
carboxylate anion

redpajama_set_name: RedPajamaCommonCrawl


Agronomic IQ is the smartest, most advanced, temperature, humidity and environment control equipment in the world.
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text:
Q: Find server IP in local network with known port in Java/Android I want to find the IP address to a server on a local network in short time. I know the port that the application is using on the server.
I've tried this, but its too slow. Even when I know the IP, the responstime is too long (like 4 seconds or so for each IP). Considered this method, it would take minutes to scan the whole subnet from 10.0.0.0 to 10.0.0.255.
        String ip = "10.0.0.45";

        try {
            InetAddress ping = InetAddress.getByName(ip);
            Socket s = new Socket(ping, 32400);
            System.out.println("Server found on IP: " + ping.getCanonicalHostName());
            s.close();
        } catch (IOException e) {
            System.out.println("Nothing");
        }
}

I could use threads, but that would still be slow. Ive seen application finding the IP in milliseconds out there. How do they do this? Java code would be appreciated!

A: You'll want to do two things - use threads to check many hosts simultaneously, and give the socket connection a lower timeout.
This answer show a very similar example.

A: I can suggest to look for source code of angry ip scanner. It is fast enough I think.
https://github.com/angryziber/ipscan

redpajama_set_name: RedPajamaStackExchange


About Us - An Event Agency With A Creative Streak In Columbus Circle | Creative Games Inc.
Erick is the founder and president of Creative Games Inc.
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The notion that an apology has two parts is rooted in its art and science.
Its science has more to do with content than its flair, from ensuring that "I'm sorry" refers to the same situation to a promise not to do it again.
Those on the receiving side, believe it or not, treasure the response. A 2009 study from the University of Nottingham School of Economics, offering complainers words or cash, found that almost 50 percent preferred the apology. Over pure hard cash.
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Austin, Blog, Conservation, Land, Stewardship, Texas, Travel, Water, Water
Behold the Bounty of the Blanco, Texas Highways magazine
https://texashighways.com/things-to-do/on-the-water/behold-the-bounty-of-the-blanco/
Behold the Bounty of the Blanco
The splendid and fragile beauty
of the Hill Country's keystone river
Photographs by Erich Schlegel
Rivers in Texas run the gamut from bucolic babbling brooks to churning whitewater, from rocky dry channels to wide and muddy waterways. The Blanco River, which winds 87 miles through the eastern Hill Country, stands out for exhibiting all of those characteristics at one time or another. I should know. The Blanco is my river.
Twenty-eight years ago, our family moved to Wimberley to be near the Blanco. I'd been hooked on swimming at Barton Springs, Austin's 68-degree spring-fed swimming pool. When it was time to move, we decided to jump ahead of the inevitable suburban sprawl while looking for another spring-fed place to swim.
I was sold on the house my wife had found the minute we drove over the Blanco on Bendigo Crossing, a low-water bridge also known as the Slime Bridge. Upstream, people were splashing around in the clear water, their laughs punctuated by shrieks of pure joy. Marco! Polo! Bright shafts of late afternoon sunlight shot through the branches of tall cypress trees hovering above the riverbank. Never mind what the house looked like.
Kayaking the Blanco near Wimberley
The vintage '70s ranch-style home needed some love and care, but it would do just fine: It was a half-mile from the Blanco and gave us river access through a property owners' park.
The first time I jumped in the Blanco, I was taken aback. The water tasted clean. The visibility underwater didn't compare to Barton Springs' clarity—the suspended limestone sediment in the Blanco clouds the water and gives the river its name, which translates to White River. But it tasted clean. Smelled clean too.
From April through October, I swim in the Blanco. It is one of the greatest pleasures I know. It's a pleasure I share with growing crowds of both locals and visitors who converge on the river's cypress-lined banks at places like Blanco State Park in Blanco; Blue Hole Regional Park on Cypress Creek, a tributary of the Blanco in Wimberley; and Five Mile Dam Park, a 34-acre Hays County park at the lower end of the river near San Marcos. On summer weekends, the parks routinely fill to capacity.
The crowds have grown as suburban sprawl has infiltrated Hays County. The county's population grew nearly 50% from 2010 to 2019, making it the nation's second fastest-growing county, according to the U.S. Census.
"The Blanco has always been a hidden gem with little access, fiercely hoarded and protected," says Ryan McGillicuddy, a Texas Parks and Wildlife Department conservation biologist who advises landowners on land management. "But the Hill Country continues to become carved up, and whether landowners like it or not, more people are coming to the river."
Over the past year and a half of COVID-19, I've gotten to know my particular stretch of the Blanco even better. Swimming in the river almost every warm day has been a saving grace. Fallow season walks have opened my eyes to the subtle shift of the seasons. The bird and bat migrations, I now realize, aren't a twice-a-year migration, but rather a constant, steady symphony of movement throughout the year.
When the wind kicks up, you can't see the Blanco's bottom for the chop. When the flow is high and fast following a flood, there's enough whitewater to haul out the kayak, and as soon as the muddy current clears up, go paddling. The river is never the same. And no matter how stressed out it might appear to get, it always comes back. The Blanco has never let me down. The question is: Can we hold up our end of the bargain?
Blue Hole Regional Park on Cypress Creek in Wimberley
The Blanco—locally pronounced "Blank-o," rather than the Spanish "Blahn-ko"—is the bellwether river of the Hill Country. It's notorious for its frequent flash floods, treasured for its semi-pristine water quality and quantity, and fretted over because of threats posed by rapid population growth. While human development encroaches the river now, it wasn't always this way. Few written accounts exist of early European explorers in Texas visiting the Blanco. The topography was too rugged, and the river valley too defended by Native Americans, particularly Lipan Apache and Comanche, who were hostile to incursions by outsiders.
Subscribe to Texas Highways
The Blanco begins as a cluster of springs in Kendall County, running shallow as it enters Blanco County and growing as it courses beyond the town of Blanco into the Wimberley Valley and Hays County. It joins the San Marcos River just downstream of the city of San Marcos. Along the way, the Blanco traverses a landscape of cliffs, steppes, canyons, tributaries, waterfalls, springs, and rapids.
The Blanco River bottom is mostly hard limestone and absent natural vegetation. Its water quality remains close to unsullied. On numerous occasions, people have told me the Blanco is the second-cleanest river in Texas. The Devils, the Frio, and the upper Nueces rivers have all been cited as the cleanest, depending on whom you're talking to. As the self-declared "King of Texas Swimming Holes," I've swum in all of these, and written about them in these pages, including stories about the Frio in 2019 and the Nueces in 2020. I'm not sure which is the cleanest, but they're all less polluted than other rivers in the state. The Blanco is hardly pristine, though. More than 100 dams and low-water crossings span the river, according to the Nature Conservancy of Texas. Riverbank and riparian habitat are increasingly fragmented as ranches are cut into subdivisions.
I've lived by the river long enough to see the Blanco go hog wild on uncontrolled rampages, swallowing trucks and trees, and killing livestock and people—most notably during the destructive and deadly Memorial Day flood of 2015. There's a reason the Blanco is the heart of what's known as "Flash Flood Alley." During extended droughts, and practically almost every August, I've watched the river slow to a trickle. My rule of thumb is the earlier in the summer, the better the swimming—as long as the spring and summer rains come. Late in the summer, if it's been dry and there's no apparent flow, I'll skip my swim and go back to the house wondering if I'll outlive the river, what with all these external pressures it faces, most of them human-related. Is the Blanco a relict, a river at the end of its run? With the local climate trending drier and hotter, is the Blanco destined to be a huge dry wash of bleached rubble, like the thousands of once-upon-a-time drainages threading through the Big Bend and the Chihuahuan Desert farther west?
The Blanco is that delicate—and that marvelous.
Proper Respects
Responsible River Recreation
The Blanco has the reputation of being a fenced-off, no-access river. Even today, trespassers can still have a gun pulled on them if they're in the wrong place at the wrong time. Respect "No Trespassing" signs and purple paint markers on fences, trees, posts, and walls. (A Texas law passed in 1997 allows landowners to use purple paint in lieu of "No Trespassing" signs, with the same consequences.) Ignoring those warnings can lead to being arrested, jailed, and/or fined, which can pretty much ruin your river experience. Don't fret. There are numerous parks where the public can access the Blanco River for swimming (see below). Always be mindful of the local environment and practice "leave no trace" principles, such as proper trash disposal, respecting wildlife, and not collecting what you find, including rocks, plants, and arrowheads.
Above: A fern grotto on the Blanco near Wimberley
David Baker at Jacob's Well
David Baker came to the Wimberley Valley in 1988 and bought property on Mount Sharp Road that included a piece of Jacob's Well. Here he started the Dancing Waters Inn.
If there is a steward of the Blanco watershed, it's Baker. If you've seen Jacob's Well, you'll understand.
Located about 5 miles from Wimberley, the deep, heart-shaped underwater cave is the source of Cypress Creek. The well begins as a crack on the limestone surface before tunneling deep into Trinity Aquifer. The mouth of the cave makes an incredible swimming hole, and the sweet sensation of diving off the rocks into the hole's cold, clear water is a rare thrill, even among other spring-fed pools.
Baker founded the Wimberley Valley Watershed Association and led the campaign for Hays County to purchase the well and its surroundings, replacing a trailer park and tennis courts with an educational and research center.
"My first impetus was to erect a fence and keep people out," Baker says. "But thinking long term, if we don't share these special places with people, they won't care if they're destroyed. They won't know. We've got to do better connecting the community to these local resources."
As the protections increase, so have the external challenges. Baker was involved in the successful four-year fight to stop a private company's plans to pump and ship groundwater out of the county, which was finally resolved earlier this year. In 2019, working with Hays County and other interested parties, Baker helped stop the City of Blanco's discharge of 1.6 million gallons daily of treated wastewater into the river. The treated water triggered algae blooms on the Blanco that extended far downstream. The town is now using the wastewater to irrigate alfalfa fields.
"These are some of the few clean rivers left in Texas, and even the most thoroughly treated wastewater contributes to their degradation," Baker says.
It's a race between conservation awareness and unfettered development in a booming region. In 2000, Jacob's Well, which provides about 10% to 20% of the Blanco River's baseflow via Cypress Creek, stopped flowing for the first time in recorded history. In 2008 and 2009, due to drought and groundwater pumping, the well stopped flowing again, and then again in 2011, 2013, and January of this year.
Despite these threats, Baker is an optimist. Last November, 70% of Hays County voters approved a $75 million parks bond for the county to secure land to protect natural resources and increase river access. And Jacob's Well, he likes to point out, has become an economic engine through tourism. In recent years, overnight lodging has contributed $70 million annually to the economy in Wimberley.
"Last year, 35,000 visitors from 28 different countries came and visited the well. Twice that many visited Blue Hole," Baker says. "When people see this, they begin to understand how this all fits together."
Five Mile Dam Park in San Marcos
I've grown to appreciate the Blanco's nuances. Some mornings the surface is smooth as glass, sunlight painting shadowy ribbons on the rock bottom. Other mornings, wind ripples the surface, the wavelets sparkling like shimmering diamonds.
My thing is jumping in and swimming about a quarter-mile upstream to the big boulder and beyond, following the contours of the riverbed as I work a steady alternating stroke, stretching, kicking, my body and mind getting locked in a rhythmic, meditative zone. The sight of a snapping turtle moving slowly across the bottom may startle, interrupting the repast. I've had the same reaction spotting gar and snakes close by underwater.
Hays County Commissioner Lon Shell
As a native of San Marcos, Hays County Commissioner Lon Shell has long known about the Blanco's beauty—and dangers. But still, he says, the growing demands on this local treasure have presented a learning curve for the community. "When we first opened Jacob's Well as a county park in 2011, we didn't understand that people from all over the country, and eventually the world, wanted to see it," he says. "That lesson has been learned."
Shell has made protection of natural resources a priority. Conserving land around the Blanco improves the river's water quality and can also mitigate the severity of flooding, he says, by directing development and impervious cover away from the river and encouraging the restoration of riparian habitat that naturally absorbs floodwaters and mitigates erosion.
"There are a lot of people in western Hays County who haven't been here that long," he says. "They see the Blanco as a river, but I don't think they respect or understand the river and its value as much as old-timers. The [2015] flood brought that to the forefront: the importance of managing the resource, conserving it, and potentially reducing the likelihood of flooding."
Shell is proudest of the Sentinel Peak Preserve, a new 535-acre park. When Shell caught wind of the pending sale of the old El Rancho Cima Boy Scout ranch, he strategized with area officials and the Nature Conservancy to secure some of the land. Located just below the rocky ridge known as Devil's Backbone, the preserve covers a milelong stretch of the Blanco River, protecting prime habitat for the endangered golden-cheeked warbler. Officials hope to have the preserve ready to open to the public by late 2022 or early 2023.
"The importance of getting people on the land and seeing the river is immeasurable," Shell says. "Signal Peak is iconic. It's the perfect spot for us to do this."
The new preserve brings hope for McGillicuddy, of Texas Parks and Wildlife. I recently caught up with the biologist as he met with science students from St. Edward's University. "With a property like Sentinel Peak, there is a rare opportunity to start with a blank slate and shape how the land can be managed for both conservation and recreation," he says.
Pulling up grasses from the bank, McGillicuddy demonstrated how they help prevent erosion and soil loss during floods. The group discussed the importance of landowner stewardship; the restoration of the Guadalupe bass, the state fish; how the Blanco is connected to Barton Springs and San Marcos Springs; the impact of the 2015 flood; and how to manage for future floods.
Such challenges are enough to turn a river lover like me into a worrywart. But the uncertainty of what's to come is balanced by experiences like an afternoon this spring. Swimming in the river, I raised my head every now and then to gaze at the line of majestic cypresses looming above the bank and to check for red-eared slider turtles sunbathing on the rocks. At moments like these, I can't imagine a more splendid place on earth.
A swimming area by the dam on the Blanco River at Blanco State Park; Five Mile Dam Park in San Marcos
Recreating on the River
While private land borders the majority of the Blanco, there are numerous opportunities to swim and enjoy the river's natural beauty.
Blanco State Park: a mile of riverfront, campsites, and cabins. 830-833-4333; texasstateparks.org
Redbud Café: soups, salads, and sandwiches on the square. redbud-cafe.com
Blue Hole Regional Park: Online reservations are required for the swimming hole on Cypress Creek. cityofwimberley.com
Jacob's Well Natural Area: Advance reservations are required for swimming, but not for the hiking trails. hayscountytx.com
Cypress Falls Swimming Hole: swimming and a hotel. thelodgeatcypressfalls.com
Creekside Cookers BBQ & Bar: great food and outdoor seating. creeksidecookers.com
Rio Bonito Resort: cabins and swimming on the Blanco. riobonito.com
7A Ranch Resort: cabins, a pioneer town, and swimming on the Blanco. 7Aranch.co
Five Mile Dam Park: riverfront with swimming and hiking. hayscountytx.com
Herbert's Taco Hut: a longtime local Tex-Mex favorite, near the bank of the San Marcos River. 512-392-2993
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My Wimberley
I SPENT SATURDAY NIGHT IN MID-APRII. Helping chaperone a dance in the cafetorium of Danforth Junior High, the school in Wimberley where my older son Jake attends eighth grade. My assignment was to guard the door at stage left, making sure no one left the building before the dance was over. I mistakenly let three boys leave after telling them they couldn't return, only to find them back inside half an hour later, reeking of tobacco smoke. Other than that mild transgression, I had a splendid evening watching young teenagers, all brimming with adolescent energy and confusion, having fun, chatting in cliques and clusters, boys with boys and girls with girls, meeting together on the dance floor to embrace gawkily whenever a slow song was played.
Nine days later, I stood at the same spot in the Danforth cafetorium at a town meeting. We'd all gathered to ponder why, just three days after a shooting rampage at Columbine High School in Littleton, Colorado, four 14-year-olds were in the Hays County Juvenile Detention Center in San Marcos on charges of conspiracy to commit murder and other assorted acts of violence and mayhem, including blowing up their school. Instead of watching kids on the verge of what for many of them would he one of the most exciting times of their lives, I saw them sitting stone-faced next to their parents, hanging on to the words of the superintendent of the Wimberley Independent School District, the sheriff of Hays County, and an assistant district attorney. Standing between the speakers at the podium and the somber audience was a phalanx of men holding video cameras backlit by bright floodlights, and television reporters whose perfect hair, perfect teeth, and stylish outfits made them stand out from the more casually dressed local residents.
According to authorities, the evidence against the four boys included bomb-making instructions downloaded from the Internet, gunpowder, and crude bombs. And apparently the boys had given police the names of specific teachers and students they had told each other they'd like to get. Many people in the audience who stepped to the microphone praised the superintendent, the school administration, and the sheriff for acting swiftly on the heels of what had happened at Columbine High School. Some called for remedies such as metal detectors, school uniforms, and prayer to ensure the students' safety. Numerous others wondered aloud how the boys, if they really did what they were accused of doing, managed to develop such anger and hate.
I had arrived back home that afternoon from a trip to Chicago on family business. While traveling, I'd seen footage of Jake's school on television framed by words and voice-overs linking Danforth Junior High to the violence in Colorado. On television even the wooden sign at the edge of town identifying Wimberley as "A Little Bit of Heaven" appeared sinister. The whole world, it seemed, was watching my community.
I just had time to pick up Jake and take him to the town meeting. I asked him a few questions about school and the students' reactions. He didn't seem to want to talk about it, so I asked him how his television appearances had gone. Jake was the newly elected president of next year's freshman class, and while I'd been out of town, several reporters had contacted him. Since I've earned a living most of my adult life as a reporter, I didn't want Jake to be afraid of the media. At the same time, I fully understood why many parents were telling their children not to speak to anyone from the press.
"They edited me down to ten seconds," Jake said.
"Welcome to the world of soundbites," I replied cynically.
After the meeting, we came home and watched Jake and my wife, Kris, on NBC's Dateline. Kris talked about the fear of Wimberley being another Littleton and voiced concern for the boys who'd been detained. Jake admitted he had once downloaded instructions on how to make a smoke bomb from the Internet a year ago. The interviewer asked him why he did it. "I was curious," Jake said, acknowledging our concern when we had learned about it.
I was relieved that Jake had said "smoke bomb" instead of "bomb." I thought that by appearing on the program maybe Jake and Kris brought a little reason into what I feared was a state of hysteria being whipped up by the media. But as we continued to talk, Kris and I started wondering if we'd done the right thing. By being forthright, had we set ourselves up?
Should we have just told the reporters no and spared our son the glare of scrutiny? Jake played Doom and Quake, and we had gunpowder in the house, in the form of Black Cat firecrackers left over from New Year's Eve. Would the authorities be paying us a visit next, confiscating computers and fireworks? Kris worried that she'd betrayed Jake's trust by telling the Dateline producers about our own downloading incident. I was so rattled I couldn't tell Jake about the item I'd read in the newspaper about the father in Port Aransas who had turned in his son for downloading bomb-making instructions from the Internet–one of numerous similar incidents across the state and the nation that week. Instead I had to advise Jake that if investigators approached him at school, as they had other students, he wasn't to say a word until we were present, along with an attorney. The four boys who'd been detained had only the count) precinct constable present to explain their rights during their initial interrogation; they weren't allowed to see their parents for more than 24 hours.
It wasn't just us. Everyone in town was uncomfortable until the end of the week, when the cameras and reporters finally left. That's when my community really got busy. Parents, students, and teachers held formal and informal meetings to discuss how to keep kids engaged, identify problems, and seek solutions. Two buildings at the Emily Ann Theatre, an outdoor theater built for high school theater productions with volunteer help last year, have been secured to organize after-school and summer activities. The programs, to he run by volunteers, are the only such alternative to a school system still facing budget cuts after eliminating programs such as art and music from the elementary school. The end-of-the-day advisory period eliminated at Danforth this year is scheduled to be reinstated next fall. Gary Weeks, a craftsman who makes rocking chairs and serves as the president of Wimberley Teens, Inc., the nonprofit parent and student organization that sponsored the dance I had chaperoned, called a meeting to try to anticipate what ninth graders in high school are going to need next year. Nathalie Harris, a parent of another eighth grader and the owner of a Christian bookstore, has organized a campaign to write letters to the boys in detention, noting that they were her daughter's friends and that instead of seeing them, her daughter sees only empty desks in her classes now. Mike Crowley, a neighbor who manages singer-songwriter Jimmie Dale Gilmore, is organizing concerts in August and October to benefit the Emily Ann and further involve the community. Churches are stepping up their youth programs, and Jake has signed up to go on a mission trip to Nuevo Laredo with the Wimberley Presbyterian Church this summer. Wimberley's like that.
At this writing, the boys are still in the Hays County Juvenile Detention Center. Something in the back of my mind tells me that in the full light of day the incident will fade away, that the evidence was factually correct but that the consequences implied by that evidence were blown out of proportion, an understandable overreaction on the side of caution in response to the events at Columbine High. Besides the shame of spending time in the juvenile detention center and being shown on television in prison orange, the four boys will in all likelihood have to attend another high school, which at this time in their tender lives is severe punishment indeed.
The sheriff and school authorities were right to act swiftly. If it could happen in suburban Colorado, it could happen anywhere, even in Wimberley. But I think the parents and friends of the boys detained were right as well. Those boys are our problem too. What prompted them to do what they did, if their intentions were in fact malicious, as has been claimed? Another eighth grader told me that one of the boys detained, who came to Wimberley from Hawaii, disliked a teacher for referring to him as "Kamikaze," reminding me of the comment of one parent at the town meeting: "If we have zero tolerance for students, shouldn't we have zero tolerance for teachers and administrators too?" The incident has prompted both Kris and me to reassess our roles as parents, with the full understanding that no matter how good a job we might do, it will never be good enough. We've tried to keep the dialogue going at our house, and there have been some bumps along the way, as there always will he. We're trying harder to listen with open minds. I still worry that in our rush to feel safe and secure we don't violate the trust that has been built up with our children over the years. If the rules and restrictions we impose on teens become too onerous, will they still feel comfortable enough to confide in us? Will they be able to make mistakes, part of the process of growing up?
On the next to last page of the same edition of the Wimberley View that ran the headline "Wimberley Shocked By Arrests of Four Junior High Boys" was a picture of the eighth-grade boys' track team. The photograph included three of the four boys detained. They looked like good kids to me, just like my kid, just like your kid. We may be relieved it wasn't our child who was detained and accused, but those four boys who are being held belong to us too, at least in a village like Wimberley. We didn't need the whole world watching our little town to understand that.
extra Team Player How George W. Bush ran the Texas Rangers and became, finally, a successful businessman. [Texas Monthly, June 1999]


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Week Seven Newsletter
A crazy late newsletter this week, as I was pretty busy today at work... go figure, right? Nevertheless, we're still rolling and getting ourselves primed up for the Waiver Draft.
Yes, it's Week Eight and we're looking to roll through this Waiver Draft... hell, we've already got one pick down and it should come as no surprise that our last place team, Chris, will take the best player available, Craig Anderson of the Colorado Avalanche. Let me tell you, he's going to need it.
Of course, these players don't actually become active on anyone's team until next Monday, we have to collect all the Draft picks, which has been known to take all week.
If you want to keep up with the Draft, the links are on the Draft Standings Page. The available players page will be updated as the week progresses, so keep up, because you can't have the same player as anyone else.
Last week's poll question picked up a few more votes than in Week Six, so I'm kind of happy about that. With nine votes this past week, seven of them said that their teams were certainly hit by injuries, in this injury-plagued year, but they still think they are far from being out of it when it comes to winning. That's great news... got to keep that optimism in place or else there really isn't much left to go on, right? I know I have had my share of injuries, but I'm right in the thick of things, so that's good. Only one team has counted themselves out of it, but I know there are a few more, just in chatting.
This week's question will surround the jersey prizes... which one would you choose if you were in first place at the end of this week? The 2010 Canada jersey with Sidney Crosby, the 2010 Winter Classic Bruins jersey with Milan Lucic or the 2010 Winter Classic Flyers jersey with Simon Gagne. That's what one lucky team will get to choose from a week from today!
It was a very close race for the Mover & Shaker award for the week, but it finished up on Sunday with a decisive conclusion, seeing Dale C. take the title at the end of the week, which netted him 34 points and 2nd spot in the standings, moving up from 4th place. This is the second straight week that the M&S moved into second place in the standings.
Being Waiver Draft week, Dale has just been knocked down a couple more positions in the actual draft itself, while a couple of teams have moved up for a better spot. This was actually a very good week to be in the Basement, if you were still fairly close to some of the money spots.
Anchoring Dale's team through Week Seven was his goaltending, which came through with 14 of his 34 points this week, thanks to Cristobel Huet's 8 points and Martin Brodeur's 6 points. His goaltending duo has the best points to 60 minutes ratio in the pool, picking up 1.5 points for every 60 minutes played this season. That is incredibly high. His highest ranking forward in the week was Andy McDonald of the Blues, who finished with 4 points, which isn't terribly high, but he only had two players with zero points in the week, so there was some consistency through his line-up.
This is Dale's second M&S mention of the season, after picking his first up during Week Three, where he had 36 points.
We are now down to the final week of the first jersey draw and Leon continues to lead the pool, but his lead has shrunk down from 16 points down to 10 points, where Dale C. is sitting. There is a 19-point gap from 3rd through 5th, which is a super longshot to pull out a jersey, but I'd hate to say its impossible, rather that it is improbable. Not to worry though, once we give this one away, we'll be done the Waiver Draft, then we'll have a couple new faces on your team to help win the second of three jerseys this season in another 8-week period of the year.
Well, we haven't seen a single-digit point total in the week since Week One, where there were only three days worth of games to be played, but John B. and his team showed us how to do it in a 7-day week. John only managed to have five of his players score for him and two of them picked up 3 points a piece (Rene Bourque of the Flames and Kimmo Timonen of the Flyers). He was hit by injuries pretty hard and had Valtteri Filppula, Marian Hossa, Saku Koivu and Alex Ovechkin on the shelf in the week, so that wasn't going to help his cause at all. In Week Eight, he should be getting Koivu and Ovechkin back, which will help him, but the big drop in the standings (from 11th to 14th), should earn him a better pick in the Waiver Draft this week.
The Player of the Week nod was also a very tight race through the week, especially through the weekend, which had a fair bit of scoring between a few guys. Finally, in the end, it was Henrik Zetterberg who came out on top with a Draft-best, 9 points in 3 games for the Red Wings. That should have made his Draft team owner, Trevor, very proud.
The week started off on the Wednesday in Columbus, where he picked up a pair of assists in the 9-1 thrashing of the Jackets. Then on Thursday night, at home to Vancouver, he had a goal and an assist in the 3-1 win over the Canucks. Saturday, he ran wild over the Ducks, picking up a hat-trick and a pair of assists in the 7-4 win. Zetterberg really made a big push this week and Trevor did move up three spots in the standings because of the good week.
It was a tough week for one of the Flyers' top lines in Week Seven. Mike Richards, Scott Hartnell and Claude Giroux had two points in two games (where the Flyers went 1-1-0) between the three of them this week. It might not have been many games to be cold in, but it was somewhat noticeable in the games of theirs that I had watched in the week.
It's now three weeks in a row that John P. has stayed atop of the standings in the Sheet pool, where he now holds onto a 35-point lead, gaining a whopping 30 points on second place in Week Seven. He has set himself up for a pretty good run already, so it will be awfully tough to beat him for a while, unless you have some pretty amazing weeks here soon.
Taking top spot in weekly scoring was Caterina, who finished with 78 points in the week. She can thank Henrik Zetterberg (9 points), Jimmy Howard (7), Martin Brodeur (6), John Tavares (5) and Mike Green (5) for all the help in getting her to the top of the heap in the week. With her big week, she jumped up from 11th to 8th, now sitting 12 points out of the money positions.
The biggest move in the pool was Dieter's, as he moved up 10 spots from 38th to 28th, which is getting him up to the top half of the draw, thanks to a few key trades a couple of weeks ago.
Trades have been coming in quite well this year, so be sure to keep your team up-to-date with trades, as they do help you in the long-term.
Other News and Notes
Well, the Thrashers have kept on rolling with Bryan Little already out of the line-up with a groin injury, but their game against the Oilers also saw the absence of Pavel Kubina, who was out due to lower-body soreness. Neither player has a timetable for a return to the line-up, but with Ilya Kovalchuk back in, the Thrashers will manage just fine.
The Sabres had Drew Stafford scratched from their line-up on Saturday night, thanks to a hip flexor injury, which he suffered earlier in the week versus the Flames. Stafford is listed as out day-to-day with the injury, so it doesn't sound like it's serious. I would imagine that he'll see another game on the shelf, but unless he hits the Injured Reserve, he should be good to return soon.
The Blackhawks had a couple of scratches against the Sharks on Sunday night, as both Kris Versteeg and Andrew Ebbett were held out of the line-up. Versteeg didn't take the pre-game warm-up, as there was no question that he would be held out of the game for some rest, while Ebbett did take the skate, but was scratched before the game got started.
After having a stint on the forward lines for the Panthers, Ville Koistinen was moved back to the blueline for a game, but ended up being a healthy scratch on Saturday night against the Islanders. Koistinen has not had the best starts to the year, scoring only one goal and three assists in 15 games.
The Kings lost the services of their top shutdown defenseman, Rob Scuderi, on Saturday night to an apparent lower-body injury. Scuderi was injured in the first period of the Kings' game against the Lightning in Tampa and didn't return to see any action. There hasn't been much for updates since the game on Saturday night, but the Kings do play on Monday in Miami, so there should be an update before that game.
The Canadiens had a surprise scratch on Saturday night versus the Predators in Nashville, as Brian Gionta was held out of the line-up with a lower-body injury. There have been no immediate details about the injury to Gionta, so you can only speculate that the injury isn't too major at the moment and that he should be considered day-to-day.
The Flyers were without their star rookie, James Van Riemsdyk, for their game against the Sabres on Saturday night. Van Riemsdyk has come down with a bout of the flu and he was not healthy enough to take to the ice. He is also playing with a broken finger, so a night off could be what he was looking for. He'll be a top pick in this week's waiver draft for sure.
Click here to see an updated injury page.
Hockey Night in Canada
Well, we're back to the ol' doubleheader in the Week Eight edition of Hockey Night in Canada, with three games during the early game coverage and then just the single late game. There is an afternoon game on another network, but we won't worry about that. It's only CBC stuff here. I don't know why, I'm not sponsored by them or anything.
In the early game across the country, we should be seeing Alex Ovechkin back in the line-up for the Capitals, as they take on the Maple Leafs in Toronto. If you thought that the Maple Leafs were having trouble with some of these regular teams, you can only imagine what the goaltending for the Leafs will have to play against on Saturday.
On other feeds for the early game, the Senators will play host to the Sabres in a Northeast Division match-up, while the Canadiens will play the Red Wings at home for the Quebec feed.
In the late game, the Oilers are going to be in tough with the high-flying Blackhawks in town. Nikolai Khabibulin will get a shot at trying to stop those young guns that he was a teammate of last season, in what should be a fast-paced game.
Posted by opiatedsherpa at 3:02 PM
Labels: blackhawks, canadiens, flyers, injury, kings, newsletter, panthers, sabres, thrashers
Week Nine Newsletter
Minor Injury for Zidlicky
Hejduk Out Day-to-Day
No Sutton for Isles
Hemsky Done
Clarkson Out Six Weeks
Sheet Scratches on Friday
Redden Out One Week
Lucic Out Again
Pair of Recalls
Sheet Scratches
Undisclosed Injury for Kotalik
Minor Injury Holds Stoll Out
Staal In, Ruutu Out
Fisher Out Tonight Vs Jersey
Hurricanes Get Staal Back Tonight
Sheet Players Waived
Hossa Returns Tonight
Spacek Day-to-Day
Briere Suspended for Two Games
Toskala Injured
Leclaire Gets Hurt on the Bench
More Habs Notes
Habs & Wild Deal
Concussion Again for Burns
Week Eight Newsletter
Kronwall Joins the IR
Back Scratches Khabibulin
Sore Back Sidelines Lupul
Wilson to Condition in AHL
Gomez Sits Day-to-Day
Ohlund Update
Panthers Lose Two to Injury
Wild Claim Ebbett
Bourque Day-to-Day
Neal Suspended for Two Games
Heading Into Weekend Eight
Havlat Out Tonight
Kovalev Away From the Team
Friday's Sheet News
Gonchar & Talbot Return
More Sheet Notes
Semin To Miss Weekend
Week Eight Waiver Draft Recap Part Three
Sheet Happenings
Smyth Out One Month
Gionta Breaks Foot
Week Eight Waiver Draft Recap Part Two
Cory Murphy Sent Down
Senators Sit Regin
Setoguchi Shelved
Pitkanen Out Again
Week Eight Waiver Draft Recap Part One
Gagner Out Day-to-Day
Ohlund Injured
Shanahan Calls It a Career
Theodore Heads Home for the Night
Filatov Gone Home
Smyth Out Tonight
Filatov Sits Again
Goligoski Out
Kunitz Out Two Weeks
Quick Updates on Saturday Morning
Little Sits Out
Knuble Breaks Finger
Heading Into Weekend Seven
Thursday Night Scratches
Sheet Defensemen Woes
Notes for the Sheet
Grebeshkov Flying Home
Ducks Without Koivu
Nylander Signs in Russia
Wednesday's Sheet News
Drury Update
An Update From Long Island
Bolland Out Indefinitely
Schneider Sent Down
Panthers Claim MacIntyre
Letang Out Two Weeks
Giguere Close to a Return
Sykora Out Indefinitely
Toews To Return
Glencross Gets Three Games
Hurricanes Lose Ward, Sign Legace
Week Six Newsletter
Islanders Lose Martinek and Weight
Saturday Morning Notes
Rask Extended
Hedman Was Rocked
Kennedy Scratched Again
Predators Update
Phoenix Without Three
Rob Blake on the IR
Word on More Canes Injuries
Krejci Out With Swine Flu
Two Sheet Scratches
Kipper Sits One Out


text:
Thyronamines - Past, present, and future
S. Piehl, C. S. Hoefig, Thomas (Tom) Scanlan, Josef Köhrle
Physiology & Pharmacology
Thyronamines (TAMs) are a newly identified class of endogenous signaling compounds. Their structure is identical to that of thyroid hormone and deiodinated thyroid hormone derivatives, except that TAMs do not possess a carboxylate group. Despite some initial publications dating back to the 1950s, TAMs did not develop into an independent area of research until 2004, when they were rediscovered as potential ligands to a class of G protein-coupled receptors called trace-amine associated receptors. Since this discovery, two representatives of TAMs, namely 3-iodothyronamine (3-T 1AM) and thyronamine (T 0AM), have been detected in vivo. Intraperitoneal or central injection of 3-T 1AM or T 0AM into mice, rats, or Djungarian hamsters caused various prompt effects, such as metabolic depression, hypothermia, negative chronotropy, negative inotropy, hyperglycemia, reduction of the respiratory quotient, ketonuria, and reduction of fat mass. Although their physiological function remains elusive, 3-T 1AM and T 0AM have already revealed promising therapeutic potential because they represent the only endogenous compounds inducing hypothermia as a prophylactic or acute treatment of stroke and might thus be expected to cause fewer side effects than synthetic compounds. This review article summarizes the still somewhat scattered data on TAMs obtained both recently and more than 20 yr ago to yield a complete and updated picture of the current state of TAM research.
Endocrine Reviews
https://doi.org/10.1210/er.2009-0040
Phodopus
thyronamine
3-iodothyronamine
Piehl, S., Hoefig, C. S., Scanlan, T. T., & Köhrle, J. (2011). Thyronamines - Past, present, and future. Endocrine Reviews, 32(1), 64-80. https://doi.org/10.1210/er.2009-0040
Thyronamines - Past, present, and future. / Piehl, S.; Hoefig, C. S.; Scanlan, Thomas (Tom); Köhrle, Josef.
In: Endocrine Reviews, Vol. 32, No. 1, 02.2011, p. 64-80.
Piehl, S, Hoefig, CS, Scanlan, TT & Köhrle, J 2011, 'Thyronamines - Past, present, and future', Endocrine Reviews, vol. 32, no. 1, pp. 64-80. https://doi.org/10.1210/er.2009-0040
Piehl S, Hoefig CS, Scanlan TT, Köhrle J. Thyronamines - Past, present, and future. Endocrine Reviews. 2011 Feb;32(1):64-80. https://doi.org/10.1210/er.2009-0040
Piehl, S. ; Hoefig, C. S. ; Scanlan, Thomas (Tom) ; Köhrle, Josef. / Thyronamines - Past, present, and future. In: Endocrine Reviews. 2011 ; Vol. 32, No. 1. pp. 64-80.
@article{22a1b1f52b0f462488216955d83da01b,
title = "Thyronamines - Past, present, and future",
abstract = "Thyronamines (TAMs) are a newly identified class of endogenous signaling compounds. Their structure is identical to that of thyroid hormone and deiodinated thyroid hormone derivatives, except that TAMs do not possess a carboxylate group. Despite some initial publications dating back to the 1950s, TAMs did not develop into an independent area of research until 2004, when they were rediscovered as potential ligands to a class of G protein-coupled receptors called trace-amine associated receptors. Since this discovery, two representatives of TAMs, namely 3-iodothyronamine (3-T 1AM) and thyronamine (T 0AM), have been detected in vivo. Intraperitoneal or central injection of 3-T 1AM or T 0AM into mice, rats, or Djungarian hamsters caused various prompt effects, such as metabolic depression, hypothermia, negative chronotropy, negative inotropy, hyperglycemia, reduction of the respiratory quotient, ketonuria, and reduction of fat mass. Although their physiological function remains elusive, 3-T 1AM and T 0AM have already revealed promising therapeutic potential because they represent the only endogenous compounds inducing hypothermia as a prophylactic or acute treatment of stroke and might thus be expected to cause fewer side effects than synthetic compounds. This review article summarizes the still somewhat scattered data on TAMs obtained both recently and more than 20 yr ago to yield a complete and updated picture of the current state of TAM research.",
author = "S. Piehl and Hoefig, {C. S.} and Scanlan, {Thomas (Tom)} and Josef K{\"o}hrle",
doi = "10.1210/er.2009-0040",
journal = "Endocrine Reviews",
publisher = "The Endocrine Society",
T1 - Thyronamines - Past, present, and future
AU - Piehl, S.
AU - Hoefig, C. S.
AU - Köhrle, Josef
N2 - Thyronamines (TAMs) are a newly identified class of endogenous signaling compounds. Their structure is identical to that of thyroid hormone and deiodinated thyroid hormone derivatives, except that TAMs do not possess a carboxylate group. Despite some initial publications dating back to the 1950s, TAMs did not develop into an independent area of research until 2004, when they were rediscovered as potential ligands to a class of G protein-coupled receptors called trace-amine associated receptors. Since this discovery, two representatives of TAMs, namely 3-iodothyronamine (3-T 1AM) and thyronamine (T 0AM), have been detected in vivo. Intraperitoneal or central injection of 3-T 1AM or T 0AM into mice, rats, or Djungarian hamsters caused various prompt effects, such as metabolic depression, hypothermia, negative chronotropy, negative inotropy, hyperglycemia, reduction of the respiratory quotient, ketonuria, and reduction of fat mass. Although their physiological function remains elusive, 3-T 1AM and T 0AM have already revealed promising therapeutic potential because they represent the only endogenous compounds inducing hypothermia as a prophylactic or acute treatment of stroke and might thus be expected to cause fewer side effects than synthetic compounds. This review article summarizes the still somewhat scattered data on TAMs obtained both recently and more than 20 yr ago to yield a complete and updated picture of the current state of TAM research.
AB - Thyronamines (TAMs) are a newly identified class of endogenous signaling compounds. Their structure is identical to that of thyroid hormone and deiodinated thyroid hormone derivatives, except that TAMs do not possess a carboxylate group. Despite some initial publications dating back to the 1950s, TAMs did not develop into an independent area of research until 2004, when they were rediscovered as potential ligands to a class of G protein-coupled receptors called trace-amine associated receptors. Since this discovery, two representatives of TAMs, namely 3-iodothyronamine (3-T 1AM) and thyronamine (T 0AM), have been detected in vivo. Intraperitoneal or central injection of 3-T 1AM or T 0AM into mice, rats, or Djungarian hamsters caused various prompt effects, such as metabolic depression, hypothermia, negative chronotropy, negative inotropy, hyperglycemia, reduction of the respiratory quotient, ketonuria, and reduction of fat mass. Although their physiological function remains elusive, 3-T 1AM and T 0AM have already revealed promising therapeutic potential because they represent the only endogenous compounds inducing hypothermia as a prophylactic or acute treatment of stroke and might thus be expected to cause fewer side effects than synthetic compounds. This review article summarizes the still somewhat scattered data on TAMs obtained both recently and more than 20 yr ago to yield a complete and updated picture of the current state of TAM research.
U2 - 10.1210/er.2009-0040
DO - 10.1210/er.2009-0040
JO - Endocrine Reviews
JF - Endocrine Reviews
10.1210/er.2009-0040


text:
EU mobile roaming charges were abolished today
Thread: EU mobile roaming charges were abolished today
Great for data use up to allowances, calls and texts could still cause unexpected charges.
Smudger
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Virgin 200Mbit
Re: EU mobile roaming charges were abolished today
Apparently, some of the companies have gone with a 'fair use' policy though, restricting how much of your data etc is eligible... Was on the One Show, so it must be true...
aniilv
Redditch, United Kingdom
the prices already went up in begging of year, which I would bet is connected to this
three canceled my contract and told to pay 5£ more, so i had to downgrade in order to not raise my monthly cost
azrael-
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VDSL 55/12 Mbit/s
I don't know how the situation is in the UK, but here in Denmark the prices have gone up at least 10-20% on most subscription plans. Alternatively, some companies gave/give you the option to switch to plans with absolutely no roaming capability.
And there's no "free" roaming as well. At least not when it comes to data. You can only roam for a given amount of GB depending on your plan.
Considering I don't really go anywhere abroad I'm a bit peeved of having to pay extra so other people can "roam" abroad.
Well, having read the article and the EU document it's still not entirely clear to me what "Roam like at home" means.
Situation 1).
I live in, and have a contract in, say, the UK. If I ring my next-door neighbour I pay standard charges, which very likely is free on contract, on maybe £0.0Xp per min on PAYG.
Now I go to Italy (for example) and ring that SAME neighbour. The call is international, and at home, inrernational calks are expensive.
So, does "Roam like at Home" mean whatever it would cost me at home is what it costs me abroad, which is minimal or free.
Live in UK, as before, and am now in Italy as before. If I call my mate in Bologna from the railway station in Bologna, is that "minimal or free" because it's "local", or expensive because the "as at home" bit means it'd be international if I called it from home.
Also, my suspicion is that sooner or later, phone companies will jack up charges, or reduce allowances, somewhere else to compensate for the lost revenue. This may get deferred a bit until they see what the effect is, such as netting off of intra-company costs and whether this simplification for users drives usage and hence revenue up. But sooner or later, if this costs them, we'll pay it some other way.
Note: In the interests of transparency and openness, I personally don't give a hoot. I don't use my mobile much at home, and very, very rarely use it, or even power it up, abroad. Last time I used it abroad has to be 10 years ago. Even then, it's calls only.
scaryjim
Not a good person
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Well, having read the article and the EU document it's still not entirely clear to me what "Roam like at home" means. ...
I don't know if it's based on more detailed advice from the EU or it's just their own interpretation of the legislation, but the way Three are implementing it is that if you're in an EU country outside the UK, all calls & texts back to the UK or to another EU country are taken from your allowance; i.e. the EU is treated as a single "country" for determining whether calls are local or not.
Interestingly, the way they've worded it on their website implies that this doesn't apply if you're in the UK; so if you're abroad the whole of the EU is treated as local, whereas if you're in the UK the rest of the EU is treated as international...
Saracen (15-06-2017)
Originally Posted by scaryjim
Well, at the moment, we (the UK) are as much in the EU as France, Germany and the 25 others are. So if the whole of the EU is local, that includes us.
We're still in, we're still paying budget contributuons, we still have the same single-market membership as the other 27, and we are still subject to EU law in the same way as the other 27.
Post-Brexit, of course, it could all change. Depending on the minutiae of any exit-deal, it probably will. But for now ....
From what I can tell with Virgin, if you're in another EU country and you call home, it comes off your allowances, but if you call someone in that country, it's classed as international.
Which asks another question, if Europe is to be seen as '1 country' with regards to roaming, why is it not the same for international calls/texts? Surely these days, it doesn't cost anything more whether the call's going to Washington DC (USA) or Washington DC* (UK)? Same with texts. I remember in 2000 being in Australia and texting home, thinking I would be coming back to a huge bill, but when I did get back, the texts had come out of my allowance. It seems it was only later on that the mobile companies realised they could make a quick profit off these, and hiked the charges...
*Durham County
Well, at the moment, we (the UK) are as much in the EU as France, Germany and the 25 others are. So if the whole of the EU is local, that includes us. ...
Oh, absoultely - and if you're in an EU country other than the UK that's how Three's contracts work - it's the same cost to call any other EU country. If you're in the UK, however, calls to any other EU country are international, and charged as such. SO it's actually better to go abroad if you want to make calls to other EU countries...
Of course, this is all subject to the usual "fair usage" caveats, but I do wonder how long it'll take before the cost of calling other EU countries from your mobile's home country comes under scrutiny....
So .... if in the UK, calls to EU countries (under 3's contract, at least) are "international". So, if you have a UK Three contract, and go abroad, then you pay "as at home", which suggests calls to Italian numbers, while in Italy, are International. However, if I call a UK number from Italy, then it's charged as if I called that number from within the UK, despite being in Italy.
But that's for Three. Other contracts vary.
Also, does that not imply that it's not "roaming" that's been freed of charges, but rather "calling your home country while roaming".
And this, to directly quote the EU, is
Originally Posted by EU Statement
one of their greatest and most tangible successes
In over 50 years?
And that's one of their "greatest successes".
Great value at only about £10,000,000,000 per year, for the UK.
Now I get what those thousands of bureaucrats have been busy doing for half a flaming century. Why did we ever consider Brexit in the face of such brilliance, nay, genius?
And yes, before this descends into a Brexit debate, I am taking the pee. Just a smidge.
So .... if in the UK, calls to EU countries (under 3's contract, at least) are "international". So, if you have a UK Three contract, and go abroad, then you pay "as at home", which suggests calls to Italian numbers, while in Italy, are International. However, if I call a UK number from Italy, then it's charged as if I called that number from within the UK, despite being in Italy. ...
Erm ... not sure
Details are at http://www.three.co.uk/feel-at-home/
In Feel at Home in Europe: calls and texts back to the UK and made between our Feel at home in Europe destinations.
You can't use your minutes allowance to make calls to local or other international numbers, Unless you are in one of our Feel at Home in Europe destinations, where calls to between European destinations will come from your allowance.
Hmmm, neither of those explicitly states that calling to a country while in that country comes from your allowance - just calls between European destimations.
Damn it, I thought I understood how that was going to work, but now I'm not so sure...
Well, Jim it's about typical for the ..... no, I'm not going there. Again.
qasdfdsaq
qasdfdsaq's system
It will be free.
It will also be free. Before the regulations came in, it varied between networks. On EE for example, it's always been free. On 3, it used to be charged as an international call. Now it's charged as an international call on 3 if you're roaming in a non-European Feel at Home country but is free in a Europe Feel At Home country, because the regulations don't affect non-Europe roaming they can continue to charge international rates for calling the country you're in.
No, that's what the case was before the new roaming regulations take effect. Now on a 3 contract calling Italian numbers while roaming in Italy comes from your allowances. 3's always been awkward and confusing as heck with their pricing and weasel wording though, so it's no surprise you'd be confused:
With Feel at Home in Europe you can use your allowances to call and text the UK and the majority of European destinations, and use your data, and it won't cost you a penny more. If you don't have any allowance left, you'll also benefit from special roaming rates. If you're in one of our Feel at Home Around the World destinations you can also use your allowances to call and text the UK and use your data at no extra cost. Calls and texts to the UK and within the EU/EEA are included in your allowance with all our plans as part of Feel At Home in Europe.
zarnywoop
Surely it means that if I'm in UK and call France; its classed as international (UK intl. rates to EU).
If I travel to France and call Italy; its classed as normal international (at UK intl. rates to EU) (Edit: unless calls across Europe are a flat rate?)
If I travel to Italy and call Italy; I'm roaming on an Italian network, its classed as a local Italy call, so it comes out of my contract allowance/charged local rate.
If I am in Italy, and call home to the UK number, then it again will come out of the allowance (or charged as if I was at home).
Last edited by zarnywoop; 16-06-2017 at 11:01 AM.
CAT-THE-FIFTH
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Less E-PEEN
Massive E-PEEN
RGB E-PEEN
Not in any order
EVEN BIGGER E-PEEN
UNDERSIZED
DOS 6.22
NOT USUALLY ON....WHEN I POST
Don't worry in two years time it will be back to normal!!


Become a player using the image above to get your Greyhorsebot Bonus in seconds (NO Deposit Required)…with this Greyhorsebot.co.uk Casino Bonus, you'll get a 200% bonus on your first deposit. Strike Rate Trainers is fully licensed and rated one of the top gambling sites by Askgamblers.com. Players enjoy HUGE Bonus Offers, Quick Withdrawals, and a Great Portfolio of Games. This greyhorsebot.co.uk deposit bonus is a limited deal ~ Don't miss it!
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text:
Niels Bohr Institute
Industrial collaboration
Niels Bohr celebrations in 2022
Newcomers and International Guests
Namely Names
Andrew D. Jackson
Theoretical Particle Physics and Cosmology
Blegdamsvej 17, 01 Bygning B, Building: 01-0-BA6
jackson@nbi.ku.dk
https://www.nbi.ku.dk/~jackson
Niels Bohr International Academy
Blegdamsvej 17, Building: Ba6
https://www.nbi.ku.dk/
Vortices and hysteresis in a rotating Bose-Einstein condensate with anharmonic confinement
Jackson, Andrew D. & Kavoulakis, G. M., 2004, In: Physical Review A (Atomic, Molecular and Optical Physics). 70, 2, p. 023601 5 p.
Phase diagram of a rotating Bose-Einstein condensate with anharmonic confinement
Jackson, Andrew D., Kavoulakis, G. M. & Lundh, E., 2004, In: Physical Review A (Atomic, Molecular and Optical Physics). 69, 5, p. 053619 7 p.
The stability of solitons in biomembranes and nerves
Reply to "Comment on 'Penetration of Action Potentials During Collision in the Median and Lateral Giant Axons of Invertebrates'"
The Kullback-Leibler divergence as an estimator of the statistical properties of CMB maps
Blegdamsvej 172100 Copenhagen
Please contact your group secretary to change your profile
Tel: +45


What can I feed my fussy horse who struggles to maintain her weight?
It can be difficult to know what to feed a horse who struggles to maintain her weight, especially if she's a fussy eater. Here, Dengie Nutritionist Tracey Hammond, shares her advice on what to do.
A variable appetite and weight loss may be cause for concern, so it'd be best to also discuss this issue with you vet.
If nothing is amiss, one of the first things to try is feeding both feed and forage 'little and often'. This mimics a horse's natural feeding regime, helps promote a healthy digestive system and avoids over-facing your mare with large meals, and it'll keep her entertained for longer in her stable.
Consider offering a variety of fibre sources in nets or buckets around the stable to encourage natural foraging behavior to keep her interested and possibly consuming more.
For condition without fizz, choose feeds based on fibre and oil for slow-release energy. Some molasses in the feed may be beneficial for tastiness, as horses tend to find molassed feeds more palatable, but look for those that contain lower levels, or choose feeds with added flavours or herbs to tempt your mare. Try different textures too - some horses prefer dry feeds while others prefer a wetter mash.
Finally, offer feed cafeteria-style - put each feed in an individual bucket and you should soon see what she is and isn't eating.
Need more advice on nutrients?


WarpQuest társasjáték - Magyarország társasjáték keresője! A társasjáték érték!
A WarpQuest egy nagyszerű társasjáték, 2 játékos részére, az átlagos játékidő rövid, csak 20 perc. A társast, 10 éves kortól ajánljuk kipróbálni. A játékmenet erősen épít a pakli tervezés mechanizmusra.
WarpQuest is an abstract game system that depicts goal driven scenarios.
In a typical WarpQuest game scenario, each player controls a collection of units attempting to reach an objective and be the first to return back to the starting point.
The units could be a party of adventuring archaeologists hoping to recover a lost artifact, a squadron of bombers attempting to hit a military target and return home, a band of samurai seeking to vanquish marauding bandits, or a company of mixed creatures seeking to destroy a piece of evil ornamental jewelry that has the nasty habit of trying to control the minds of all free creatures.
The scenarios that use the WarpQuest engine will hold the details.
A Victorian themed version of the system in presented in the Artifact Core Rules.
Warp Quest was an entry in the 2002 Microgame Design Contest. The contest edition included War Over the Reich, Lost Continent of Atlantis, and Mummys Tomb.


text:
The Holocaust - never again must mankind stumble this way
Ein Mann legt eine weiße Rose an den drei Stolpersteinen für verfolgte Berliner Richter während der NS-Zeit vor dem Oberverwaltungsgericht Berlin-Brandenburg nieder. Foto: Britta Pedersen/dpa, © dpa-Zentralbild
Jan 27 is UN International Holocaust Remembrance Day. Germany's ambassador in Singapore looks at why learning about the conditions that led to genocide is relevant today.
If you walk the streets of Berlin, you will come across the famous "stumbling stones", or Stolpersteine. They will not literally make you stumble - but they are meant to make your mind stumble.
Just under 10 sq cm, easy to miss, they are small brass stones, embedded underfoot in the cobblestones of the street. Each commemorates a Holocaust victim in front of their last-known freely chosen place of residence. Stolpersteine are meant to commemorate all victims of Nazi Germany. The stones honour Jews, Sinti and Roma, and other people who the Nazis labelled "asocial".
The inscription on each stone begins "Here lived", followed by the victim's name, date of birth, and fate: internment, suicide, exile or, in the vast majority of cases, deportation and murder.
To read the inscription, you must bow before the victim, as one of the project initiators emphasises. Gunter Demnig, the German artist behind the grassroots project, has, over more than two decades now, laid more than 70,000 "Stolpersteine", making them the world's largest decentralised monument to the Holocaust.
Among the many monuments linked to Holocaust remembrance, this is probably the initiative that links commemoration closest with everyday lives in Germany.
The Holocaust refers to the systematic, state-sponsored persecution and murder of about six million Jews by the Nazi regime and its collaborators. And this also must be said: The perpetrators were human beings. They were Germans. The worst crime in the history of humanity - it was committed by my countrymen.
This heavy, historical burden of guilt brings about a responsibility that does not expire. There cannot be an end to remembrance. This collective responsibility was woven into the very fabric of the Federal Republic of Germany from day one.
At the international level, the United Nations has designated Jan 27 as a day of remembrance of the victims of the Holocaust. The date marks the liberation of the Nazi concentration and extermination camp of Auschwitz-Birkenau in 1945.
DANGERS OF FANATICISM
The international day is not only an opportunity to commemorate the victims but also a means to raise awareness around the world, especially among young people, of the danger that persists still in the form of racist and fanatic ideologies targeted against ethnic or religious groups.
From the horror of Auschwitz, the world learnt lessons. The nations of the world built an order of peace, founded upon human rights and international law. Germany is committed to this order and determined to defend it, together with people across the globe, including in Singapore.
Germans are grateful for the spirit of reconciliation that has allowed their country to form strong and peaceful relations with other nations.
We wish we could say that remembrance alone confers immunity to evil, but it does not.
Evil comes back in different forms in different eras. This is why the Holocaust commemoration is not just about the past but also the present and the future. By our present efforts to protect and promote the dignity of all human beings, we seek to ensure the horrors of genocide do not happen again in any part of the world. "Never again! Nie wieder!" is a watchword with universal significance.
As Mr Kofi Annan, the late UN secretary-general, once explained, education on the Holocaust is being promoted internationally not just for its historical significance, but also "because, in our increasingly diverse and globalised world, educators and policymakers believe education about the Holocaust is a vital mechanism for teaching students to value democracy and human rights, and encouraging them to oppose racism and promote tolerance in societies".
THREE REASONS WHY
Here are three examples why teaching and learning about the Holocaust remain meaningful and essential today.
First, this can prompt learners to develop an understanding of the mechanisms and processes that lead to genocide, in turn leading to reflection on the importance of the rule of law and democratic institutions.
This enables people to identify circumstances that can threaten or erode these structures, and reflect on their own role and responsibility in safeguarding these principles.
Second, people learn to more critically interpret and evaluate cultural manifestations and representations of the Holocaust and thereby minimise the risk of manipulation.
Time and again, German embassies, including those in South-east Asia, are alerted to the presence of Holocaust-related content - particularly on social media. Sometimes, it turns out to be thoughtless and not meant to offend, but sometimes it is deliberately provocative.
In many countries, the Holocaust has become a theme or motif in both popular culture and political discourse. Teaching and learning about the Holocaust can help people identify distortion and inaccuracy when the Holocaust is used as a rhetorical device in the service of social, political and moral agendas.
Third, while Nazi Germany may feel far away in time and space from Asia, the knowledge and insights gained from learning about the Holocaust can serve as a guide in unpacking and analysing the decisions and actions taken (or not) in times of tumult by a range of actors - from nations to communities to individuals.
The circumstances may be vastly different from the Holocaust but echoes may be found in the dynamics and calculations (fear, greed, peer pressure or indifference) driving these decisions and actions. To be able to discern them and know the possible trajectories of decisions taken is to be better armed against a revival of the conditions that led to the Holocaust.
Everyone can, and should, help build bulwarks against Holocaust denial, intolerance and hatred. These are international challenges, and countering them requires as much an international response as one that is on the spot.
Taking up this challenging subject in a global context provides a way for all to learn how to welcome and appreciate difference and diversity on the basis of respect and tolerance.
This article was written by Dr Norbert Riedel, German Ambassador to Singapore. Germany currently holds the presidency of the International Holocaust Remembrance Alliance.
It was first published in The Straits Times on 27 January, 2021.
Learn more about the Holocaust from a Hybrid Panel Discussion with scholars from Germany, Israel and Singapore on occasion of the United Nations International Holocaust Remembrance Day on 27 Jan 2021:
Hybrid Panel Discussion on Universal and Educational Lessons from the Holocaust
Overview "Startseite"


The Lincoln County Child Advocacy Center is fully equipped with a Medical Evaluation room where our volunteer Medical Physician examines our child victims. We are very thankful to have a dedicated Medical Physician who is specially trained in the examinations and forensic evidence collecting of child physical and sexual abuse victims. The medical exam is a child friendly examination that may include a wellness exam, STD and pregnancy test (when appropriate), and specific exam techniques for alleged sexual assault.


The Department of Education's Strategic Plan 2018-2021 identifies the goal of early learning – From birth to 8 years of age, children are confident, involved learners and effective communicators.
Tasmania's Strategy for Children – Pregnancy to Eight Years 2018-2021 will help us achieve our collective vision of 'Children Thriving in Strong Connected Communities' through a focus on quality, equity and partnerships. We also have a Guide to Reading and using Tasmania's Strategy for Children and an Action Template available.
For information on B4 and how you or your organisation can become more involved in the early years please visit this website.
The Department's initiative on Working Together for 3 Year Olds is an initiative that will be available for eligible children with the greatest need, with access being guided by a set of criteria to include children who are three years old by 1 January in any year from 2020 (i.e. the year before Kindergarten).