text:
Q: Checkbox isn't taking action til my cursor leaves it I have about ten check boxes that each implement different functions. I am trying to make one master checkbox that will
a) check all 10 checkboxes;
b) implement the functions in each
I have gotten one to work but for some reason, when I check it, the others aren't checked until I move my mouse off of the master checkbox (after checking it). Bizarre, right? Here is the code for the master checkbox and the sub-checkboxes. (I have to warn you that I am a little new to javascript and it's possible that this is terribly written. Advice in that direction also welcome.)
/*change all buttons of a single genre*/
$("a[id^="+genre+"_]").attr("class",  modereplacement+"Button" + " showButton");
$("a[id^="+genre+"_]").attr("onClick", function(index, currentValue){ return currentValue.replace(mode, modereplacement) ; });
$("#"+"all_"+genre+'_cur').attr("onClick",function(index, currentValue){ return currentValue.replace(mode, modereplacement) ; });

/*check all checkboxes*/
if (category =='All')
{
    $("#"+"alls_cur").attr("onClick",function(index, currentValue){ return currentValue.replace(mode, modereplacement) ; });
    for (var i = 0 ; i < 13 ; i++)
    {
        /*change individual buttons*/
        var currentgenre = allgenre[i];
        $("a[id^="+currentgenre+"_]").attr("class",  modereplacement+"Button" + " showButton");
        $("a[id^="+currentgenre+"_]").attr("onClick", function(index, currentValue){ return currentValue.replace(mode, modereplacement) ; });

        /*change Quick button*/
        $("#"+"all_"+currentgenre+'_cur').attr("onClick",function(index, currentValue){ return currentValue.replace(mode, modereplacement) ; });
        $("#"+"all_"+currentgenre+'_cur').prop("checked", (mode == "offx"));

    }
}

And here is the HTML that implements the 'Check All' aka 'Watch All' buttons:
 Watch All
       <input type='checkbox'  id='alls_cur' onclick=\"watchgenre( $user_id,'All','alls', 'offx', 1);\" ></input>
       <input type='checkbox' $checkname  id='alls_fut' onclick=\"watchgenre( $user_id,'All','alls', 'offx', 2);\" ></input>

Thanks for any advice you are able to give

A: something like this?  http://jsfiddle.net/swm53ran/118/
the below shows a snippet of the code in teh demo. the demo is showing that there are 5 check boxes and 1 check all checkbox. each box, when checked, triggers its div to have a colored background. when unchecked, it's background changes to white.  the check all checkbox checks all the other check boxes and triggers their actions with the line: $(this).trigger('change');.  This line of code simulates a .change() event for each of the checkboxes

    <input type="checkbox" class="chkbox check1"/> Background gray

    <input type="checkbox" class="chkbox check2"/> Background lightgray

<input type="checkbox" class="checkAll"/> Check All

$(document).ready(function() {
    $('.checkAll').on('change', function() {
        if($(this).is(':checked')) {
            $('.chkbox').each(function() {
                $(this).prop('checked', true);
                $(this).trigger('change');
            });
        }
    });
    $('.check1').on('change', function() {
        if($(this).is(':checked')) {
            $(this).closest('div').css('background-color', 'gray');
        }
        else {
            $(this).closest('div').css('background-color', 'white');
        }
    });
    $('.check2').on('change', function() {
        if($(this).is(':checked')) {
            $(this).closest('div').css('background-color', 'lightgray');
        }
        else {
            $(this).closest('div').css('background-color', 'white');
        }
    });
});

hope this helps!
btw, just in case you didnt know .change() or .on('change') is an event triggered when the state of the checkbox changes (from checked to unchecked and vice versa)

A: try to use events (like onclick ) in jQuery like this_
$("selector").on("click", callbackOrFunction)


Nintendo has announced Super Mario Maker 2 for Switch. Metroid Prime 4 is in the works as well, but with development having been handed off to Retro Studios, who rebooted the project, it's safe to say we won't see a new Metroid for at least a year.
Outside of that, the Direct will be a whopping 35 minutes long. Luigi's Mansion 3, Daemon X Machina, and Switch installments of Animal Crossing and Pokemon have also been announced for this year, although none of those have received release dates yet.
One certainty is that we'll be receiving more detail on the elusive Fire Emblem: Three Houses. Join us, won't you? Finally, Nintendo will also be streaming the Direct on its website, and while it's only embedded the YouTube stream, you can head over there if you want to get the full Nintendo effect.
For now, keep reading for everything we know about the game so far. We know how much Nintendo can pack in in such a short space of time, so get ready to have your hearts broken when they don't reveal the Jet Set Radio Future remaster we've all been waiting for... Visit the Nintendo.com game page here.
Metroid Prime Trilogy could be coming to Switch very soon indeed. That doesn't necessarily stop Nintendo from making a surprise 3DS announcement, but that seems unlikely given what the company has already said about the Direct. "We have made a decision to re-examine the development structure and change it".


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The highly publicized case involving the stabbing death of a Coral Gables student has finally reached its conclusion with the exception of any appellate matters that they may be heard by the 3rd District Court of Appeal. Andy Rodriguez appeared at his sentencing hearing with his Miami criminal attorney. The circuit court judge presiding over the case ordered the defendant to spend the next forty years in prison. If that was not bad enough, the judge tacked on 10 years of reporting probation once the defendant concludes his prison sentence. The courtroom was packed with reporters and family members from both the victim's and the defendant's family members. While the sentence levied by the judge appears harsh at first blush, it could have been a lot worse.
The defendant was charged by information with second degree murder and convicted by a jury of the same offense. Because the defendant was not charged with or convicted of capital first degree murder, the decision on the sentencing was left up to the judge with no input from the jury. A second degree murder case is non-capital and therefore only a 6 person jury will decide whether a defendant is guilty or not-guilty. First degree murder cases, which are capital offenses, entitle a defendant to have a jury consisting of 12 jurors. The sentencing process varies a little. In cases where Defendants are convicted in capital first degree murder cases where the death penalty is being sought by the prosecution, the jury will vote on whether or not to impose the death penalty. The judge of course has the ultimate decision when the sentence is actually imposed. In all other cases, the six or twelve person will have no say in the sentence whatsoever.
In the case involving Rodriguez, the defendant decided to make a statement before the judge handed down the sentence. In all cases, a defendant is permitted to make a statement after he or she has been found guilty. Well thought out and planned statements can cause a judge to hand down a more lenient sentence than you would normally expect. In this case, the statement given to the judge at the sentencing hearing was quoted as being "tepid" and not overly heartfelt. The defendant in his statement denied the crime. Denying the crime after a criminal conviction shows a lack of acceptance of responsibility and lack of remorse which will have deleterious effect on the judge. That is why it is important for a criminal lawyer to prepare his or her client for the hearing. Another way to persuade a judge to hand down a lighter sentence is for defendant's to have his or her friends and family speak on their behalf. A good support structure goes a long way with a judge, depending on the crimes charged and convicted of, of course.
The judge in this case also sentenced the defendant to 10 years of probation after he completes his prison sentence. Whether the matter of probation was appropriate or not has been discussed around town. Probation sentences are usually ordered for first time offenders who did not qualify for the pre-trial intervention program, most likely because of the charge. After sentencing someone to 40 years of prison, a follow-up probation sentence hardly makes sense. Just because the judge sentenced the defendant does not mean he will serve the entire prison sentence. He will about serve 85% of that time provided there are no significant infractions during the prison stay. Cases where a judge sentences someone to life or cases involving minimum mandatory sentences do not allow for the 85% (gain time rule).
Forty-Year Prison Term for Coral Gables High Killer, Miami Herald.com, November 29, 2011.


While South Africa's wineries may not get as much attention as those of the Old World, they have developed a strong reputation over the years. Wine was first produced in what is now South Africa in February 1659, according to Jan van Riebeeck of the Dutch East India Company. By the end of the 17th century, wine production in the region had grown so much that the colony started to export wines to Europe.
Production grew to 4 million liters per year by the end of the 18th century and continued to increase in the 19th century, when the British took control of the Cape from the Dutch. With this change and with greater ship traffic, vineyard areas doubled in size, with 31 million vines planted by 1825. Although the country's wine industry has since experienced ups and downs, its vintners produce some outstanding wines celebrated by wine lovers throughout the world.
The following is a look at two of South Africa's oldest and most recognized wineries: Spier Wine Farm and Vergelegen Estate.
Dating back to 1692, Spier is located in the famous Stellenbosch wine region. Committed to sustainability, Spier has earned Conservation Champion status from the World Wildlife Fund-South Africa (WWF-SA). A farm as well as a vineyard, Spier grows wine grapes and other produce without the use of pesticides or artificial fertilizers, and livestock and chickens roam freely without exposure to hormones or antibiotics.
Spier produces a number of award-winning wines across five collections. Spier white wines include the 2016 Ideology Sémillon and the 2016 21 Gables Chenin Blanc, which won the IWSC Chenin Blanc Trophy in 2018. Its red wines include a 2012 Blind Astronomer Pinotage and the Spier Signature Cabernet Sauvignon. The winery also makes the 2016 Farm House Organic Rosé, which is made with hand-picked organic Shiraz grapes.
Visitors can sample Spier's wines paired with fresh cuisine at Eight Restaurant, which sources its food from the vineyard's farm or nearby producers. The vegetables served are free from artificial chemicals and pesticides, and the sirloin, sausages, and filets come from Spier's own grass-fed cattle. Dishes include the Farmer Angus pork neck steak and the grass-fed Farmer Angus rump, while vegetarians can choose from the twice-baked spinach soufflé or the sweet potato gnocchi, which is served with mushrooms, spinach, and broccoli.
Another dining option at Spier Wine Farm is Vadas Smokehouse and Bakery, which overlooks the beautiful estate. Guests can choose from a variety of slow-cooked meats, such as pork neck, lamb shoulder, and beef brisket, which are smoked at a low temperature. Finally, Spier Wine Farm sells picnic baskets packed with cheeses, wines, and charcuterie. Guests can purchase a basket to enjoy under the beautiful ancient oak trees or near the estate's dam.
Established in 1700, Vergelegen stands out as one of the most beautiful wineries in Cape Town. The name means "situated far away," which is fitting given that it is located in the Hottentots Holland mountain range, which took three days to reach via ox wagon at the time it was developed.
Over the course of its more than 300-year history, the estate has been owned by several explorers and influential settlers, including Willem Adriaan van der Stel, governor of the Cape Colony from 1699-1707. After purchasing the land in 1700, he created a beautiful homestead by planting vines and trees, cultivating fruit orchards, building cattle stations, and digging irrigation canals.
The estate preserves its natural beauty and now features a gravity-flow cellar with the classic Cape aesthetic. The octagonal cellar complements the octagonal garden developed by van der Stel and sits on a hill that offers beautiful views of Table Mountain and False Bay.
Vergelegen produces a number of award-winning wines, including the 2015 G.V.B. White, a blend of Sauvignon Blanc and Sémillon that earned 92 points from Stephen Tanzer in the International Wine Report. Red wine enthusiasts should be sure to try the 2012 Cabernet Sauvignon, which is considered one of Vergelegen's best wines in the last three decades. The winery produced 30,000 bottles of this vintage, which earned 92 points from Tanzer.
Vergelegen serves its wines at its Camphors at Vergelegen restaurant, named after the huge camphor trees that van der Stel planted on the estate in 1700. The restaurant has been recognized by JHP Gourmet Guide on its list of 21 exceptional South African restaurants and has earned recognition multiple times in the Eat Out Mercedes Benz Restaurant Awards. The menu includes a diverse array of entrées, such as dry-aged duck with rhubarb and shiitake mushrooms and atchar-glazed hake with mussels and turnip.
Guests can also opt for a more casual dining experience at the Stables at Vergelegen, a bistro-style eatery with gorgeous views of the mountains. Finally, those who want an authentic vineyard experience can enjoy a white-tablecloth picnic in the estate's beautiful camphor tree forest. With their long history and beautiful vineyards, Spier Wine Farm and Vergelegen Estate offer a great introduction to South African wines. Before visiting, read up on the most recent vintages to get an idea of the best wines to sample. Also, be sure to call ahead if you plan to dine at the restaurants. You may find that South Africa becomes one of your favorite wine destinations after you tour these beautiful estates and sample their exceptional wines.


BIRDS (Friendship): This round, reversible pendant features a sloth and reads: "The best mirror is an old friend. a friend is a gift you give yourself. If you want to make a friend, let someone do you a favor."
RABBIT (Family): This round, reversible pendant features a rabbit and reads: "You don't choose your family. They are god's gift to you, as you are to them. The family is one of nature's masterpieces."


Students participating in the 2016 APL NASA Intern Program will work at the APL facility in Laurel, Maryland, and will contribute to NASA missions and space-related research work. Students selected for this program will receive a stipend ($4,500 for undergrads, $5,500 for graduates, and $6,500 for Ph.D. students) for the 10-week program, and housing will be provided at the University of Maryland. Talks by key mission engineers and scientists, along with tours of APL, will be provided throughout the summer. Interested intern candidates must be U.S. citizens, be in high academic standing (3.0 GPA or higher) and have successfully passed a background check (criminal, social security, and driving record).
The APL NASA Intern Program runs for 10 weeks, from June 6 to August 12, 2016.
Housing is provided at no additional cost at the University of Maryland (move in on May 31; move out on August 13).
Standard weekday work hours are 8:30 a.m. to 5:00 p.m., Monday–Friday.
APL will be closed on Monday, July 4, 2016, in observance of Independence Day.
Copyright 2019 The Johns Hopkins University Applied Physics Laboratory LLC. All rights reserved.


Following the opening of the Delano in South Beach Miami, its sister property in Vegas has found its home at the Mandalay Bay Resort and Casino. Channelling a Miami-cool vibe into Vegas, the 43-story gold tower hotel features high-end design in its spacious all-suite accommodations. At Rivea, an Alain Ducasse restaurant, find dishes inspired by the food markets of Provence and Italy, while the variety of beach clubs and beachside casinos in both hotels are ideal for lively evening warm-ups or simply lounging in a tropical oasis.


text:
Q: Change the way JRadioButtons displayed on JPanel I have a JPanel, and I want to add JRadioButtons to it, this is the code I tried :
private void populateQuestionnaire(Question question){
            buttonGroup = new ButtonGroup();
            for(Choix c : question.getListChoix()) {
                radioButton = new JRadioButton(c.getChoixLibelle());
                buttonGroup.add(radioButton);
                jPanel1.add(radioButton);

            }
            jPanel1.revalidate();
            jPanel1.repaint();
    }

And I have the layout of JPanel is FlowLayout.
This is how the JRadioButtons displayed :

I want JRadioButtons to be added one below the other and to be centered in the JPanel.

A: Instead of using a FlowLayout, which lays out items left to right and wraps appropriately, you can use a BoxLayout, which allows you to specify laying out items either horizontally or vertically.
You can set the LayoutManager for your JPanel at construction:
JPanel jpanel1 = new JPanel(new BoxLayout(parentComponent, BoxLayout.Y_AXIS));

A: BoxLayout is great for stacking elements on top of each other. Consider this code:
public class MyFrame extends JFrame {

    public MyFrame() {
        ButtonGroup bg = new ButtonGroup();
        JRadioButton b1 = new JRadioButton("My Button 1");
        JRadioButton b2 = new JRadioButton("My Button 2");
        bg.add(b1);
        bg.add(b2);

        BoxLayout bl = new BoxLayout(this.getContentPane(), BoxLayout.Y_AXIS);
        this.setLayout(bl);

        b1.setAlignmentX(CENTER_ALIGNMENT);
        b2.setAlignmentX(CENTER_ALIGNMENT);

        this.add(b1);
        this.add(b2);
    }

}

Which makes, when instantiated and shown, the following window:

Now let's look at how this code works:
Consider this code:
ButtonGroup bg = new ButtonGroup();
JRadioButton b1 = new JRadioButton("My Button 1");
JRadioButton b2 = new JRadioButton("My Button 2");
bg.add(b1);
bg.add(b2);

This code does the same thing you were doing before, only a little simpler for example's sake. It creates a button group and two JRadioButtons, then adds the buttons to the button group. Now here is when it gets interesting.
Next, consider this code:
BoxLayout bl = new BoxLayout(this.getContentPane(), BoxLayout.Y_AXIS);
this.setLayout(bl);

The first line creates a new BoxLayout with the following parameters:
1 The container which it is laying out. (It needs this because it can't be shared.)
2 The axis which it should be laying out components. (You want Y-AXIS for your case.)
The second line set's the JFrame's contentPane's layout to the BoxLayout you just created.
Finally, consider this code:
b1.setAlignmentX(CENTER_ALIGNMENT);
b2.setAlignmentX(CENTER_ALIGNMENT);

this.add(b1);
this.add(b2);

This sets the alignment of the two radio buttons so that their centers will be aligned to each other and to the center of the frame. Then it adds them to the frame's content pane.
Hope this helped!
Note: The reason I used this.getContentPane() while constructing the BoxLayout instead of just using this is because when working with JFrames commands like add() and setLayout() get redirected to the frame's content pane. So if we were to use this in the constructor, when we called this.setLayout(bl) we really would be calling this.getContentPane().setLayout(bl). But, we just told the BoxLayout it'll be laying out the frame, not it's content pane, so you'll get an exception saying that the BoxLayout can't be shared. To correct the error, we just need to realise that we are actually working with the content pane through the frame's methods, and update the BoxLayout's constructor accordingly to let it know what it really is laying out.

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text:
Oktoberrevolutie (Russisch: Октябрьской Революции, Ostrov Oktjabrskoj Revoljoetsii) is het middelste en grootste van de vier grote eilanden van de Noordland-archipel (Severnaja Zemlja) in het Russische deel van Noordelijke IJszee, tussen de Karazee in het westen en de Laptevzee in het oosten. Aan noordwestzijde wordt het gescheiden van Pionier en Komsomolets door de Rode Legerstraat (ca. 4 km), aan zuidoostijde van Bolsjevik door de Straat Sjokalski (18 km) en aan westzijde van de Sedov-archipel door de Straat Vostotsjny (ca. 2 km vanaf het schiereiland Commune van Parijs).

Geografie
De oppervlakte wordt geschat op ca. 14.000 km². De kust van het eiland loopt aan oostzijde steil af naar de Laptevzee. Aan westzijde bevindt zich een laaggelegen sedimentaire kustvlakte, bestaande uit kwartaire afzettingen. Op verschillende plekken steken baaien en fjorden het land in, waarvan de Matoesevitsjfjord (aan noordoostzijde) tot 60 kilometer doorloopt. De belangrijkste hoogten van het bergachtige eiland bevinden zich in het oosten, in de rotsachtige gebergten aldaar, die vaak zijn overdekt met gletsjers, die meer dan de helft van het eiland (7.600 km²) overdekken en aflopen naar de zee. De hoogste bergpiek is de Karpinski (963 meter), die onderdeel vormt van de Karpinskigletsjer aan oostzijde.

Het eiland telt vijf koepelvormige ijskappen; vanuit het noorden met de klok mee dragen deze de namen Roesanov (tot 704 meter hoog), Karpinski (963), Universiteit (800), Vavilov (728) en Albanov (524). Een andere kleinere ijskap op het eiland is de Maljoetkagletsjer. De ijsvrije delen, met name de kusten en het centrale deel bestaan uit poolwoestijn, toendra, stranden en laaggelegen kliffen. De hoogste ijsvrije piek is de Bazarnaja (594 meter).

Het centrale deel van het eiland is vrij van glaciale bedekking en bestaat uit een laaggelegen gedenudeerde vlakte, die bestaat uit Beneden-Paleozoïsche afzettingen en die wordt doorsneden door een aantal rivieren, die op plekken door diepe kloven voeren. De rivieren Podemnaja en Bolsjaja stromen naar het noordwesten tussen de gletsjers Vavilov en Albanov en de rivieren Bedovaja en Obryvistaja naar het noorden tussen de gletsjers Albanov en Roesanov.

Rondom het eiland bevinden zich ongeveer 50 kusteilandjes. De grootste ervan is Najdjonysj ("vondeling") aan oostzijde. De grootste eilandengroep bij het eiland zijn de Rode Vlooteilanden aan zuidwestzijde, waar zich van 1953 tot 1991 een poolstation bevond op het eiland Bolsjoj.

Geschiedenis
Het eiland werd voor het eerst onderzocht tijdens een expeditie tussen 1931 en 1932 van het Instituut voor het Onderzoek naar het Noorden, waaraan Nikolaj Oervantsev, Georgi Oesjakov, Sergej Zjoeravljov en Vasili Chodov deelnamen. Van 1935 tot 1937 bevond zich een weerstation bij Kaap Olovjanny aan zuidoostzijde.

Aan noordzijde van de Vavilovgletsjer werd in 1974 het poolstation Vavilov opgericht, dat in 1988 werd gesloten. In de sovjetperiode bevond zich aan zuidzijde van het Zjiloj-schiereiland (ten oosten van het Commune van Parijs-schiereiland) bij Kaap Vatoetin een voormalige basis van waaruit vanaf 1957 expedities werden uitgevoerd voor het bepalen van het reliëf van de zeebodem in de kustgebieden van de eilanden van Noordland. Van 1981 tot 1988 had het Arctisch en Antarctisch Onderzoeksinstituut aldaar een wetenschappelijk onderzoekstation, waarna het werd verplaatst naar Kaap Baranov aan noordzijde van Bolsjevik.

Na de heiligverklaring van de laatste Russische tsaar en zijn familie werd in 2005 gepoogd om het eiland 'Heilige Alexandra' (Святая Александра) te vernoemen, hetgeen in 2007 echter geblokkeerd werd door het huis van afgevaardigden van de kraj Krasnojarsk.

Eiland van Noordland
Onbewoond Russisch eiland

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Is It Possible To Have A Log Burner Without A Chimney?
If you've always dreamed of snuggling up in front of a beautiful crackling stove and taking in the wholesome, rich smell of woodsmoke, what do you do if you find yourself in possession of a property without a fireplace or chimney?
Can A Wood Burning Stove Heat Your Whole House?
Friends or relatives of yours may have memories of their whole home being heated by a single stove. Nowadays, in the time of radiators and underfloor heating, this might just sound like a romantic and rustic myth - so is it really possible?
Can You Buy A Gas Stove Online?
When you're on the hunt for something new, it's now a natural and straightforward approach to first work out a clear idea of the products you want, then buy them online and get them delivered without further ado.
Which Is Cheaper to Run, an Electric Fireplace or a Gas Fireplace?
If you're lucky enough to find yourself at the exciting stage of choosing a new fireplace as part of the refurbishment of a living space or reception room, it's likely that you're quickly realising just how many options are available to you - not only in terms of look, but also when it comes to fuel sources.
Give your Fireplace or Stove a Pre-Spring Makeover!
If your fireplace or stove is looking a little grubby and sooty after the winter, there are a few, very straightforward ways to return it to its former glory and even possibly give it a whole new look. Read on for a few ELB Fireplace tips and tricks for the perfect fireplace makeover.


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text:
New Dolphins Coach, Veteran Of The Patriots Way, Must Confront Legacy Of Losing, Mediocrity
Miami Dolphins Are Gunning To Play Home From Super Bowl LIV As a parade snaked through Boston's streets on Tuesday to celebrate the winning of another Super Bowl by...
Miami Dolphins Are Gunning To Play Home From Super Bowl LIV
As a parade snaked through Boston's streets on Tuesday to celebrate the winning of another Super Bowl by the New England Patriots, Brian Flores was considering how to make something similar happen in Miami.
Miami will be the site of Super Bowl LIV next year and the Dolphins surely won't be in it. The biggest question surrounding the team is not whether it can compete for a title – it can't – but how extensive and lengthy the teardown and rebuild will be.
Flores, who was the Patriots linebackers coach and defensive signal-caller, steps into replace Adam Gase, fired after three seasons and a 23-25 record (and now the New York Jets head coach). Flores is accustomed to winning; the Dolphins are not.
They haven't won a Super Bowl in four decades or a playoff game in 18 years. They've won the AFC East, the division owned by the Patriots, once since 2000. They've had one 10-win season since 2009 and have been outscored by their opponents each of the last four years.
This will not require culture change. It will require an entirely new mind-set for a team that has questions at quarterback, running back, offensive line and defense. Where do we begin?
"You fix that on a day-to-day basis. Everyone tries to improve every day. You take it one day at a time," Flores said in his introductory news conference. "There is a selflessness and a 'put the team first' attitude that you have to have, and that goes from the owner to the general manager to the head coach to the people who clean up at nighttime. If you can get everybody to buy into that, then good things will happen. I believe that."
The Dolphins have not improved on a yearly basis. Maybe one day at a time, boring as that sounds, will be the way to go.
Post By: Larry Weisman, a longtime sportswriter for USA TODAY, blogs for Twistity.com. Follow him on Twitter @MrLarryWeisman
Larry Weisman	February 7, 2019
2020adam gasebrian floresCoachFootballLivMIAMI DOLPHINSNewsNFLreplacementsportsSuper Bowl
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The Mystery Of Engin's Hair Solved, Plus Other Items
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-- From the Greensboro News & Record's SportsExtra blog:
On Friday, [Atsur] finally broke under intense scrutiny from the media and revealed the reason why his once close-cropped hair is now resembling afro status.
Apparently Atsur continue to let his hair grow out because it pleases N.C. State SID Annabelle Vaughan, who thinks Atsur looks - and I'm quoting accurately here - "cute" with long, curly hair.
Also, Atsur - ever the college student - pointed out that not getting a regular haircut helps him save money.
[Edit: On second thought, this joke prolly wasn't a good idea.]
-- I watched the debut of Knight School on ESPN yesterday. Please don't judge me too harshly. The show wasn't very good, though I liked the part where Knight removed a ball from practice because it had been "dribbled too much." Watching a bunch of guys with questionable talent fumble the ball around the court brought back memories of my own days as an intramural basketball player of questionable talent. All the familiar faces were there on the show, too: Slow Footed, One-Dimensional Shooter Guy; No-Pass Guy; Self-Important "I'm The Point Guard" Guy; Needs Four Put-Backs To Make One Layup Guy... It brought a tear to my eye, it really did.
-- Caulton Tudor points out a big reason why NC State needs to beat Carolina on Wednesday: to increase its chances of playing in Greensboro for the NCAA tournament's opening weekend.
Carolina defeated State, then ranked No. 13 nationally, by 13 points in Chapel Hill on Jan. 7. Should the Tar Heels pull out a win at Raleigh, a regular-season series sweep would be weighed heavily by the NCAA selection and seeding committee. If the two teams do not face each other again during the ACC Tournament, Carolina could get the nod.
NC State already has the edge in RPI, but it's a small one. If State were to beat Carolina, the Pack would almost certainly finish the regular season with a better conference record than the Heels (at worst, they would tie), which, when combined with the advantage in the RPI standings, would make NC State the pretty clear choice for Greensboro.
-- From Doyel's Dribbles:
Reasonable people disagree about the Indiana job.
Not talking about me. For one thing, I'm not reasonable. For another, I'm not a coach.
But this weekend I did speak with two coaches whose names have been tossed around regarding the Indiana job. In both cases, we spoke off the record. They were brutally honest. And in brutal disagreement.
One coach says Indiana is a top-five job nationally. He mentioned Duke, North Carolina, Kentucky and Kansas. "Indiana might be fifth, but it's in the top five," this coach told me. "Indiana is a place you can go and win national championships."
One coach says Indiana isn't even the best job in the Big Ten. This coach says the Indiana job isn't as good as Michigan State or Ohio State. "The facilities are terrible, the salaries haven't been that good, and the fans are brutal," this coach told me. "It's a job that looks good because of Bob Knight, but that's it."
The more I thought about this, the more I started to lean towards the second coach's opinion. What makes the Indiana job more compelling than tOSU (barring NCAA sanctions) or Michigan State? A school's tradition and the quality of its head coaching position aren't always as closely related as fans like to think they are. Along with losing its elite status (in terms of results), Indiana has also lost a lot of its cachet. And I'm not just talking about the Mike Davis era--the last 5-6 years of Knight's tenure didn't do the program many favors either.
I'm not going to delve too deeply into a situation that I'm not familiar with, but I thought the negative comments from the anonymous coach were interesting. Times change.


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Mountains Of Trouble: The Kashmir Conflict
By Amos Chapple
Seventy years of hostility in the Himalayas has led Pakistan and India back to the brink of major conflict.
1 Ringed by the world's highest peaks and streaked with precious waterways, the Kashmir region lies behind almost every conflict between India and Pakistan since the British Empire left the continent.
2 Louis Mountbatten, the last viceroy of British-ruled India. In 1947, the departing British authorities oversaw the slicing up of India along religious lines. The partition sparked the largest mass migration in history.
3 As Muslims flooded west and east to the newly formed Islamic "homelands" of today's Pakistan and Bangladesh, Hindus and Sikhs moved in the opposite directions.
4 In the chaos, mobs attacked their religious counterparts in violence that killed hundreds of thousands and shocked the world.
5 In 1947 Kashmir had a mostly Muslim population but a Hindu ruler. Maharajah Hari Singh (pictured in London) needed to decide if his region would join India, Pakistan, or become an independent state.
6 As the maharajah wavered, violent uprisings broke out and tribal militants sent from Pakistan infiltrated the region in a bid to seize it by force. This rare photo shows one of the Pathan fighters, swaddled in looted clothing, after his capture by Indian troops.
7 Finally, in late October 1947, the maharajah requested military help from Delhi and signed a declaration to join his mountainous fiefdom with India. The maharajah fled to safety, and Indian troops arrived in Kashmir to seize control. But the chronology of those events remains bitterly disputed.
8 Female fighters being inspected by Indian Prime Minister Jawaharlal Nehru in Kashmir in 1947. Many argue that Maharajah Singh had left the region before signing the accession and therefore had no right to declare Jammu and Kashmir's union with India.
As the two countries dug in on their respective claims in Kashmir, the disputed region was split into a Pakistani-held north and Indian-held south. The "line of control" was to become the front line of the ensuing conflict. The United Nations recommended that India prepare for a referendum that would decide whether Kashmir would join with India or Pakistan, a vote that was never held.
10 Indian troops patrolling the Kashmiri mountains in 1965. Pakistan and India have fought three wars over Kashmir, most recently in 1999.
11 An Indian soldier leaps from a blazing government compound after it was attacked by militants in 2005. Violence in Indian-administered Kashmir has been nearly continuous but surged after 1989, when a Pakistan-backed insurgency against Indian rule began. Since then, more than 20,000 people have died in the violence.
12 A demonstration in Pakistan in 1998. That year, both India and Pakistan acquired nuclear weapons, further raising the stakes in the ongoing dispute over Kashmir.
13 Indian police in Kashmir grieve at the funeral of four colleagues killed during a shoot-out with a militant in 2008. As well as attacks on Indian troops, Islamic fundamentalists in the heavily Muslim Kashmir Valley have reportedly targeted and intimidated religious minorities.
14 Indian police beat Kashmiri demonstrators in 2008. Indian authorities have been accused of unlawful killings, torture, and sexual violence against civilians in the ongoing conflict.
15 In 2016, militant leader Burhan Wani (seen on a poster during a rally in Pakistan) was killed in a shoot-out with Indian forces in Kashmir, sparking deadly demonstrations. Pakistan's prime minister prompted Indian outrage when he referred to Wani as a "martyr."
16 In February 2019, the Kashmir conflict again flared up when a suicide bomber slammed his explosives-laden car into a bus carrying Indian police. Forty-one people were killed.
17 India's response to the deadly bombing met with failure on February 27. One day after a bombing raid on what India described as a militant camp in northeastern Pakistan, at least one Indian fighter jet was downed and its pilot (pictured) captured.
18 Pakistan pledged on February 28 to hand over the captured pilot as a "gesture of peace." Meanwhile, India's prime minister struck a more combative tone, vowing less than two months before a general election that his country would "fight as one."
Amos Chapple
Amos Chapple is a New Zealand photojournalist with a particular interest in the former U.S.S.R.
ChappleA@rferl.org
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Pilot Shot Down By Pakistan Returns To India


Doug von Koss is an artist, teacher and performer who presents chanting workshops, poetry performances, rituals and other festive surprises from coast to coast.
Teaching by call and response, in a "perfection free zone," Doug draws upon world music to create with chants and songs an almost instant chorus of radiant voices. His passion is to guide circles of community through ecstatic and sacred experiences of harmony and beauty that celebrate the human spirit.
Doug is the artistic director of The Noah Project, a men's ritual performance group in the San Francisco bay area. Gratitude Goulash, his joyful book of poetry is doing well on Amazon.
Having retired from a life in theater and film, for the last twenty years Doug has been a senior teacher at the Redwood Men's Center in California, The Minnesota Men's Conference, and The Great Mother and New Father Conference.


I don't have amazing skin. AT ALL.
In fact, I didn't get acne until AFTER high school. I turned 18, went to my first semester of college, and my face turned into a 15 year old's acne nightmare.
So as a adult-acne survivor, I LOVE seeing my not-so-perfect skin looking smooth, creamy, and oh-so-perfect in images. It makes me feel like a million bucks!
So as much as we photographers care about the artistry, background, light, and composition of our images (all very important still) the BIGGEST thing that most of our clients care about is looking NATURAL.
In fact, with everything else being equal, your clients will (1) be the most happy with their images and (2) look their best if their skin looks as naturally perfect as possible.
Well, there's no magic post processing tricks to get skin tones just right after a shoot (although there's a bunch of Photoshop actions that try pretty hard).
It's really all about how you CAPTURE the image in your camera.
The best way to get your clients to look their best and have the most natural skin tones is to shoot the image "properly" at the time of capture.
When selecting a location to shoot, if you have the ability to choose between two locations, ALWAYS choose the one with the better light over the better background.
Light wins over background. Every time.
QUANTITY is the measure of how much light is present - or how bright the light is.
QUALITY is how pleasing the light actually is.
Harsh sunlight on someones face has a lot of Quantity, but not a lot of Quality.
Conversely, imagine sunlight striking a giant white building on the other side of the street, reflecting off that building and producing a soft, white light that illuminates your subject in a flattering way.
The easiest way to make a judgement about the quality of the light is to hold your hand out in front of your face, at arms length, and look at the skin on the palm of your hand.
That soft skin on your palm is similar to facial skin, so the palm of your hand will tell you how someone's skin tone will look in the light you're choosing.
Move your hand around, and study how the light changes on your hand while turning in different directions.
This is something that Jeff and I do all the time - just ask our clients.
When we're walking around on a shoot, we're constantly checking our hand and looking for a skin tone that is bright, clean, and true-to-life - not super red, green, or blue - but a fresh, balanced white.
Find a room that is dark and only illuminated by a window. Hold your palm a few feet away from the window facing toward the window.
Notice that the quality of light is very even and pleasing on your hand, right?
Now slowly move away from the window (where it becomes darker) and watch how that light changes quite quickly.
Go outside and find a big shady spot like the shade of a building or a tree.
Stand right at the edge where the shadow ends, and hold your palm facing out away from the shadow while walking forwards and backwards (if your body is facing towards a building, for example, you're palm will be facing towards your face away from the shadow).
Notice how quickly the light changes on your hand as you move deeper into the shadow.
Also notice how nice and creamy the light is right at the edge of the shadow and the harsh light.
As you do this in different environments (by trees, different colored buildings, near water, near glass buildings) you'll begin to "see" how light changes, where it's reflecting, and where to position your subjects for the best skin tones based on what you like on the palm of your hand.
2. Overexpose. But just a little bit.
Friends, the importance of exposure can't ever be underestimated.
It's always best to have the exposure that you want straight out of the camera, instead of brightening up your images in post.
The less work you do on the backend, the better!
So if there's any "tricks" that we do, it's that we overexpose skin tones a touch - by about 1/3 stop - all the time.
When your eye sees an image, it confuses brightness for smoothness, so if we overexpose for skin, we'll get it looking a little brighter and therefore a little smoother and appealing.
This is a really delicate thing because if you overexpose by too much (say, a full stop) you're going to get into some issues with white balance.
So use this trick sparingly, and with practice.
What this mean, is that if we don't absolutely nail the color temperature or exposure during the shoot (even though we try so very hard!), we'll be able to adjust it after the fact to give the most appealing skin tones possible if we shot it in RAW instead of JPG.
In addition, since RAW files contain so much more color information, we're able to make really fine color and contrast adjustments to get things super perfect.
Hopefully this helps - if you have any follow-up questions, if I can clarify anything, or if you've simply got a burning question you've been dying to ask, head on over to our Photographer-Only Facebook Group!


Showing our 2 Charles Faram Hops Charles Faram 100g Hop Pellets - Northern Brewer (2017 Harvest Alpha 7%) reviews with an average rating of Excellent. Would you like to write a review?
5Great, cheap and on time.


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Post Tagged with: "Intellectual Property"
The Broadcasting Act Blunder, Day 14: The Risk to Canadian Ownership of Intellectual Property
The Broadcasting Act blunder series has previously examined Bill C-10's enormous cost to the foundational elements of Canadian broadcasting policy including the beginning of the end of Canadian ownership and control requirements and how it downgrades the role of Canadians in their own programming. There is another significant cost that comes from a bill that Andrew Coyne of the Globe and Mail describes as "one of the most radical expansions of state regulation in Canadian history." At a time when the government has emphasized the importance of intellectual property, the bill opens the door to less Canadian control and ownership over its IP.
December 9, 2020 — 4 comments — News
Canadian Government Consults on Expanding Pacific Trade Treaty to UK, Taiwan, South Korea, and Thailand
The Canadian government has launched a public consultation on expanding the Comprehensive and Progressive Agreement for Trans-Pacific Partnership (CPTPP, formerly TPP) to other countries, specifically citing the UK, Taiwan, South Korea, and Thailand. The consultation could raise significant concerns as the UK would be the first non-Pacific country in the agreement and Taiwan could spark a response from China. Moreover, opening the agreement to new countries must likely factor in the possibility that the U.S. might want to re-enter the agreement if there is a change in administration in 2020.
July 30, 2019 — Comments are Disabled — News
NAFTA Modernization and IP/E-commerce: My Appearance at the Senate Open Caucus
I appeared earlier this week before the Senate Open Caucus to discuss the IP and e-commerce implications of the NAFTA renegotiation. The panel, which included Jerry Dias, Al Mussel, and Brenda Swick, featured an engaging discussion with senators from across the political spectrum. My opening remarks emphasized three points from a Canadian perspective: meeting international standards, doing no harm, and seeking a level playing field. The comments are posted below.
October 20, 2017 — 4 comments — Committees, News
Canada's National IP Strategy: My Submission on Awareness, Administration and Innovation
The Canadian government announced plans for the development of a national IP strategy in this year's budget. The Ministry of Innovation, Science and Economic Development held a series of roundtables late last month and invited public comment. The comment period closed earlier this week and the submissions should soon be posted online. My submission is posted below.
Drawing on prior writing and committee appearances (and some overlap with NAFTA issues), the submission focuses on three broad areas: IP awareness, administration and fostering innovation. The innovation piece forms the majority of the submission with discussion of seven issues: knowledge transfer strategies, IP abuse and misuse, fair use/flexible fair dealing, anti-circumvention legislation exceptions, artificial intelligence, crown copyright and copyright term.
July 20, 2017 — 3 comments — Committees, News
Budget 2017: Why Canada's Digital Policy Future Is Up For Grabs
Canadian Finance Minister Bill Morneau released his government's 2017 budget today and while the spending promises may be underwhelming for some, the documents sets out an ambitious agenda for digital policy review. In fact, with changes to copyright, patent, broadcast, telecom, net neutrality, digital taxes, fintech, Canadian media, and Cancon all under consideration, the coming year will have enormous implications for the future of Canada's digital policies.
The budget does include several spending promises, including $13.2 million over five years to support an affordable Internet access program, $50 million for kids coding programs, $29.5 million over five years for digital literacy, and $14.9 million for digitization of Indigenous language and materials. There is also new money for the growth of artificial intelligence sector and the much-anticipated revamping of innovation funding programs.
Yet the biggest digital implications may ultimately come from the policy reforms. First up may be new digital sales taxes. The budget includes a commitment to extend sales taxes to ride sharing companies such as Uber, a move that seems likely to ultimately lead to a broader extension of sales taxes to digital services such as Netflix.
March 22, 2017 — 8 comments — News


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All miRNA treatments were at a concentration of 30 nM premiR per
Posted on January 28, 2016 by hsdp4869
All miRNA treatments were at a concentration of 30 nM premiR per well. Twenty-four Cisplatin hours post-transfection, cells were lysed and RNA isolated for further analysis using TRI Reagent? (Sigma-Aldrich) according to the manufacturer��s specifications. Complementary DNA (cDNA) synthesis and quantitative reverse transcription polymerase chain reaction (qRT-PCR) for miR-126 miRNA expression was measured using Taqman miRNA assays (Applied Biosystems) according to the manufacturer��s instructions, and qRT-PCR was performed on an LC480 Lightcycler (Roche, Basel, Switzerland). Expression of miRNA relative to ��-actin was determined using the 2(?����Ct) method.27 All qRT-PCR experiments were performed in triplicate, including no-template controls.
cDNA synthesis and qRT-PCR for TOM1 Equal quantities of RNA were reverse transcribed into cDNA using a Quantitect reverse transcription kit (Qiagen, Valencia, CA, USA). The cDNA resulting from this reaction was used as a template for qRT-PCR using SYBR Green (Roche) on the LightCycler 480 PCR system (Roche). The expression of TOM1 relative to ��-actin was determined using the 2(?����Ct) method.27 Primers for TOM1 and ��-actin were obtained from MWG Eurofins Genetics (Ebersberg, Germany) (TOM1-F 5��-ATTCTGTGGGCACTGACTCC-3�� and TOM1-R 5��-CACTCACCATCTCCAGCTCA-3��, ��-actin-F 5��-GGACTTCGAGCAAGAGATGG-3�� and ��-actin-R 5��-AGGAAGGAAGGCTGGAAGAG-3��). Statistical analysis All analyses were performed using GraphPad Prism 4.0 software package (San Diego, CA, USA). Results are expressed as the mean �� standard error of the mean and were compared using the Student��s t-test (nonparametric, one-tailed).
Differences were considered significant at P �� 0.05. Results Characterization of miRNA nanoparticles GSK-3 Characteristics such as size, zeta potential (surface charge), and degree of complexation or encapsulation all affect the delivery, efficiency, and toxicity of nanoparticles, and the preparation methods were optimized to produce small miRNA-loaded, PEI, and chitosan nanoparticles that complexed and condensed miRNA. Large particles, with sizes greater than 1,000 nm, were obtained when PEI was complexed with premiR-126 at N/P ratios of 1:1, 3:1, and 5:1 using PBS as the diluent (Figure 1). These sizes are likely due to aggregation of nanoparticles. Using a higher N/P ratio of 10:1, a reduced size of 588 �� 34 nm was obtained. Using 5% (w/v) glucose as the complexation diluent for preparation of PEI:miRNA nanoparticles instead of PBS, much smaller complexes were obtained.
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Facy and coll (23), commenting
Facy and coll. (23), commenting Dorsomorphin manufacturer on their case series, are indicating the theoretical possibility of adding a TC to D-CAA but then exclude a practical realization due to the high rate of complications reported from others (47). Our experience does not confirm this: the exteriorized colonic stump opposes to the sphincteric tone of the anus and seems to work as a means of protection for the healing of TC. Conclusion In conclusion P-T confirms a reliable and reproducible surgical procedure – anything but surpassed and forgettable – a useful alternative especially in extreme restorative resections. To us it represents the preferential option for total proctectomies or ISR by VL access and with primary reconstruction.
Moreover, in more complex situations affecting rectum and anus, in pelvic reinterventions, in the larger group of patients at increased risk of anastomotic leakage, and when a sufficient rectal stump cannot be salvaged, D-CAA – with the technique we described – confirms as a precious resource. D-CAA deserves to be rediscovered and valorised especially if, by integrating a TC, it is possible to confirm on a more ample scale the positive functional results obtained by our study.
Severe acute pancreatitis (SAP) management has changed over the last fifteen years, and from too aggressive behaviour, we moved to a cautious one. In every case, we can appreciate defect of extremist conceptual position. We reviewed our strategy on disease treatment, and we analyzed treatment of single cases. We collected 4 SAP cases from January 2009 to January 2010.
All patients were septic, and we adopted the same approach for all of them, avoiding surgery without peritoneal infection. In all patients we placed jejumostomy and, after cleaning of septic site, we started immediate enteral nutrition (EN). Antibiotic therapy against Gram+, Gram? and antifugal drug had been started. No one died and all patients were back to an active life even if social costs are considerably high especially due to very long hospital stay. Keywords: Pancreatitis, Endoscopic, Surgical, Nutritional, Therapy Introduction Severe acute pancretitis (SAP) treatment has changed during the last fifteen years. From too aggressive behavior, we moved to a too cautious one, on both cases, we can appreciate defects of extremist conceptual positions. Critical review of our cases allowed to point out single treatments.
Patients Dacomitinib and methods Four case of SAP observed during a year from January 2009 to January 2010, reflect therapeutic behavior adopted. All patients had an APACHE II score > 10, and each one has been treated by same conceptual approach, that reserves surgical approach to infection of pancreatic necrosis. CG, 54 years old, man, hyperamylasemia 16000 U/l, plenty painful onset after dinner. Patient has been admitted to another hospital, on the fourth day he has been transferred to our ward.
CCLC use among American high school students is alarming given pe
CCLC use among American high school students is alarming given perceptions surrounding CCLC use and its associated negative outcomes. Marketing campaigns depict these products as more socially acceptable and fashionable than cigarettes and also as potential cessation aids. CCLC selleck inhibitor use is commonly perceived as a healthy alternative to and less addictive than smoking cigarettes (Baker et al., 2000; Iribarren, Tekawa, Sidney, & Friedman, 1999; Jolly, 2008; Malone, Yerger, & Pearson, 2001). However, relative to cigarettes, CCLC include higher levels of carcinogens (i.e., nitrosamines), tar per gram of tobacco, and toxins (Baker et al., 2000; National Cancer Institute [NCI], 1998). Furthermore, CCLC contain more tobacco (1�C20 grams) and require longer smoking intervals than cigarettes, resulting in increased exposure to carbon monoxide, hydrocarbons, ammonium, and cadmium (Baker et al.
, 2000; Kozlowski et al., 2008; NCI, 1998). Given this, it is not surprising that use of these products is accompanied by a dose-dependent risk for significant deleterious health outcomes including chronic obstructive pulmonary disease and cancers of the mouth, lung, esophagus, and larynx (Baker et al., 2000; Boffetta et al., 1999; Dollar, Mix, & Kozlowski, 2008; Rodriguez et al., 2010; Shapiro, Jacobs, & Thun, 2000). Understanding the correlates of CCLC use is particularly critical among cigarette users given that this population is more likely to use CCLC than noncigarette smokers (CDC, 1997; Delnevo et al., 2004; Soldz, Huyser, & Dorsey, 2003).
Approximately 50% of current cigarette-using students in the United States also use other forms of tobacco (Bombard, Rock, Pederson, & Asman, 2008; Gilpin & Pierce, 2003; Tercyak & Audrain, 2002), with CCLC use representing the most common form of additional tobacco use (Bombard, Pederson, Koval, & O��Hegarty, 2009; Rigotti, Lee, & Wechsler, 2000). In a sample of young adults from a 10-year cohort study, 10% used only cigarettes compared with 26% who used both cigarettes and other forms of tobacco (Bombard et al., 2009): the most likely combination of tobacco use was cigarettes and CCLC (67%; Bombard et al., 2009). Taken together, use of both cigarettes and CCLC is alarmingly prevalent among American high school students, which necessitates a more nuanced profiling of this subpopulation of tobacco users. Several studies have shown that polytobacco users exhibit different demographic and behavioral Drug_discovery profiles than cigarette-only users (Smith-Simone, Curbow, & Stillman, 2008).
e , Table 1) Again, combination therapy produced generally lower
e., Table 1). Again, combination therapy produced generally lower 8-week smoking rates than monotherapy. Further, as is the case in the All Mono ABT-888 and All Combo comparisons, the discrepancy in smoking rates between monotherapy and combination NRT conditions is significant in all cells except that of the combination of high-context exposure and low FTND1 scores. The relative 8-week smoking risk was 86% in individuals receiving combination NRT versus monotherapy NRT in this cell and ranged from 72% to 77% in the other three cells. The Effectiveness Trial data showed that combination pharmacotherapy produced significantly better results in most smokers, except those who were low in nicotine dependence and who lived with a spouse who smokes.
For the Efficacy Trial, Table 2 shows the sample sizes, 8-week smoking rates, and relative risks of smoking when using dependence (FTND1) and the context exposure (SPOUSE SMOKES) variables to categorize smoking risk. Table 2 shows that, as in the Effectiveness analyses, the rate of smoking was significantly lower in the All Combo condition versus the All Mono condition in only three of the four cells constituted by the crossing of the FTND1 and context exposure variables. For instance, when subjects had a low FTND1 score and low-context exposure, 53% were smoking by 8 weeks among those receiving one of the monotherapies compared with only 42% in comparable cells in the combination therapy condition. However, among subjects who had low FTND1 scores and high-context exposure, 58% were smoking if given monotherapy and 56% were smoking if given combination therapy.
Relative risk data also showed that combination pharmacotherapy benefitted all groups except those with low FTND1 scores and high-context exposure. The Efficacy trial also comprised a placebo control group. This group was smaller in size than the pharmacotherapy Brefeldin_A conditions by design (n = 188), conferring little power for statistical comparisons. However, this group showed a risk pattern similar to that of the monotherapy participants, with high FTND1 scores predicting a greater risk of 8-week smoking than was found in the low-dependence group (78% vs. 66%). The same analyses were conducted in the Efficacy sample using only the NRT treatments. These analyses showed that combination therapy generally produced lower 8-week smoking rates than did monotherapy. However, in the Efficacy trial, the smoking rate was higher in individuals with low FTND1 scores and high-context exposure who received combination NRT versus monotherapy NRT (i.e., 61% vs. 55%); thus, the relative risk of smoking was 111% in the combination NRT subjects versus the monotherapy NRT subjects in the low-dependence/high-context exposure cell.
Chronic infection was defined by positive total core antibody (an
Chronic infection was defined by positive total core antibody (anti-HBc), positive HBsAg, and negative surface antibody (anti-HBs). Immunity to HBV infection was defined Alisertib purchase as positive for anti-HBs (��10mg/IU) and either negative (vaccinated) or positive (past HBV infection) for total anti-HBc. Susceptible to infection was defined as negative for all HBV serologic markers. Retrospective Cohort Study A retrospective cohort study was performed to identify risk factors associated with developing acute HBV infection. The study cohort included ALF residents (as of March 1, 2010) who were uninfected and at risk for experiencing acute infection before the investigation (i.e., residents chronically infected or immune were excluded). All statistical analyses were performed by using SAS? 9.2 (SAS Institute, Inc.
, Cary, NC). We calculated an overall attack rate for acute HBV infection and risk ratios (RRs) and 95% confidence intervals (CIs) for each risk factor assessed. HBV DNA Sequence Analysis The relatedness among virus obtained from resident specimens with detectable HBV DNA was assessed by genotyping and sequencing of the full viral genome. Genotyping was based on the HBV S-gene sequence (nucleotides 222�C656) [23]. Whole-genome sequencing was conducted as published elsewhere [24]. Viral sequences from infected residents were compared with each other and with selected viral sequences from the CDC Division of Viral Hepatitis library, which were used as a reference group. Phylogenetic analysis with MEGA5 (Biodesign Institute, Tempe, AZ) used the neighbor-joining method to construct a dendrogram [25], [26].
Results Setting The ALF had 160 beds in 2 adjacent buildings with 2�C3 residents/room. Among 139 residents present in March 2010, median age was 59 years (range: 28�C93 years); 57 (41%) were female; 82 (59%) were black; and median duration of residence at the facility was 1,645 days (range: 1�C8,364 days). Neuropsychiatric diagnoses were documented for 129 (93%) residents and included schizophrenia (95), other psychiatric diagnoses (45), mental retardation (21), seizure disorder (20), substance abuse (13), dementia (11), stroke (7), and traumatic brain injury (5). A majority of residents were dependent on Medicaid and Supplemental Security Income to pay expenses. Among 36 ALF employees, 3 were trained to perform AMBG and administer insulin injections, including a licensed practical nurse, a certified nursing assistant, and a registered medication aide. However, AMBG was also performed routinely by direct care staff, who are unlicensed and comprise the majority of ALF employees. Staff usually rotated between buildings, but some worked Brefeldin_A routinely in a single building.
PCR products following website were clearly detectable in chromatin fractions immunoprecipitated with RAR antiserum (Fig. 2B). In contrast, no PCR products were detected when we used IgG as a control in this assay (Fig. 2B). Thus, our analysis provides evidence that RARs specifically bind to the predicted RARE within the human ISX promoter. Figure 2. RARs directly bind to the ISX promoter in the ChIP assay. A) Schematic representation of the retinoic acid response element (RARE) in the human ISX promoter region, along with PCR primer pair locations. B) ChIP assays in CaCo-2 cells were performed with … ISX represses SR-BI expression in HepG2 cells Previous studies in mice provide evidence that ISX directly controls BCMO1 expression (18).
It has been reported that the expression of SR-BI is highly increased in ISX deficiency (15), but it is unknown whether SR-BI is a direct downstream target of ISX. To address this question, we cloned the full-length human ISX from CaCo-2 cells and tranfected it into the human hepatocyte cell line HepG2, a cell line that expresses SR-BI (26). The transfection efficiency was determined to be 67 to 72% using a GFP-reporter construct (data not shown). We performed immunoblot analysis for SR-BI using total protein extracts of these transfected HepG2 cells. As shown in Fig. 2C, SR-BI protein levels decreased in HepG2 cells ectopically overexpressing ISX as compared to cells transfected with the vector alone. Quantification revealed a decrease of SR-BI protein levels to 57% after 48 h and 43% after 72 h of the levels in nontransfected cells (Fig. 2D).
Considering the transfection efficiency, the remaining SR-BI expression can be attributed largely to nontransfected cells (33%). Thus, we conclude that ISX repressed the expression of SR-BI in HeG2 cells. RA induces ISX expression in vitamin A-deficient mice Our studies in human cell lines showed that ISX is an RA target gene. Therefore, we next analyzed retinoid dependency of ISX expression in a mouse model. The lecithin:retinol acyl transferase (LRAT)-deficient mouse model cannot convert retinol to retinyl esters; hence, it lacks liver vitamin A stores and possesses only trace amounts of retinyl esters in most other tissues (23, 27, 28). Due to impaired vitamin A storage, LRAT-knockout mice are highly susceptible to dietary vitamin A-deficiency (27, 28).
To induce vitamin A deficiency in these mice, we fed 8-wk-old LRAT-deficient animals a diet lacking any source of vitamin A (n=5) or a vitamin A sufficient diet (n=5). After 2 wk, we sacrificed Entinostat animals and performed qRT-PCR analysis with duodenal and jejunal RNA preparation. In animals subjected to vitamin A depletion, ISX mRNA levels were decreased (5.2- and 3.6-fold in duodenum and jejunum, respectively), whereas SR-BI mRNA levels (4.2- and 3.8-fold in duodenum and jejunum, respectively) and BCMO1 mRNA levels were increased (25- and 8.
68% of the HBsAg-positive subjects (79 75% of ASCs, 54 43% of the
68% of the HBsAg-positive subjects (79.75% of ASCs, 54.43% of the CHB patients, 62.57% of the LC patients, and 50.15% of the HCC patients); the preS region was sequenced from 47.14% of the HBsAg-positive subjects (41.14% of ASCs, 51.90% of the CHB patients, selleck inhibitor 54.19% of the LC patients, and 45.05% of the HCC patients). Of the HBV-infected subjects, 741 (36.85%) had the HBV mutation data in the two regions. The HBV mutations including T1674C/G, A1762T/G1764A, T1753V, C1653T, and G1896A in the EnhII/BCP/PC as well as preS deletion, preS1 start codon mutation, preS2 start codon mutation, C2875A, A3120G/T, C7A, and C76A in the preS region were significantly associated with an increased risk of HCC, while C1730G and C1799G were inversely associated with HCC risk [39].
The associations of the SNPs with the frequencies of all the HCC-related HBV mutations were assessed using the data of the HBV-infected subjects including the HCC patients. It was found that pri-miR-34b/c rs4938723 CC genotype was significantly associated with increased frequency of T1674C/G, while pre-miR-196a2 rs11614913 TC genotype was significantly associated with increased frequency of G1896A (Table 3). Table 3 The associations of the polymorphism with the HCC-related HBV mutations using the data of all HBV-infected subjects. Contributions of the Interactions of the SNPs with the HBV Mutations to HCC Risk Contribution of each SNP and its multiplicative interaction with the HCC-related HBV mutations to HCC risk were assessed using multivariate regression analyses, adjusted for covariates including the HBV mutations.
The contributions of the SNPs and their multiplicative interactions with HBV mutations in the EnhII/BCP/PC region or in the preS region were calculated by adding each SNP and the interaction term to the same multivariate regression model. In the study subjects with the data of HBV mutations in the EnhII/BCP/PC region, pri-miR-34b/c rs4938723 in dominant genetic model was significantly associated with an increased risk of HCC whereas its interaction with C1730G, a HBV mutation inversely associated with HCC risk, was significantly associated with a reduced risk of HCC; the interaction of pre-miR-196a2 rs11614913 TC genotype with G1896A was significantly associated with an increased risk of HCC (Table 4).
In Cilengitide those with the data of HBV mutations in the preS region, pri-miR-34b/c rs4938723 in dominant genetic model was significantly associated with an increased risk of HCC whereas its interactions with viral mutations were not significantly associated with HCC risk; the interaction of pre-miR-196a2 rs11614913 TC genotype with A3120G/T was significantly associated with a reduced risk of HCC, although A3120G/T was a risk factor of HCC (Table 5). Table 4 Contributions of pri-miR-34b/c and pre-miR-196a2 polymorphisms and their interactions with the HBV mutations in the EnhII/BCP/PC region to the risk of HCC in multivariate regression analyses.
Genogroup II has the highest circulating frequency, and GII 4 gen
Genogroup II has the highest circulating frequency, and GII.4 generally predominates as the most commonly-detected genotype molarity calculator in epidemic norovirus gastroenteritis [12], [14]�C[16]. Currently, there are no vaccines or antivirals available to prevent or treat norovirus gastroenteritis. Soon after the discovery of noroviruses in 1972 [17] and rotaviruses in 1973 [18], the NIAID Laboratory of Infectious Diseases (LID) of the National Institutes of Health collaborated with the WHO to determine the role of viruses in childhood diarrhea globally, particularly in developing countries [19]. The LID examined 438 fecal specimens obtained between 1976 and 1979 from infants and young children (including 2 adults) with diarrhea for the presence of rotaviruses and the Norwalk agent, the first detected norovirus genotype, GI.
1 [17], [19]. Rotaviruses were detected by an enzyme-linked immunosorbent assay in 27% (n=118) of the cohort, which was consistent with the WHO recommendation for rotavirus vaccine development [19]�C[21]. However, a radioimmunoassay developed for the detection of GI.1 Norwalk virus failed to detect any norovirus strains [19], [22]. The availability of new diagnostic assays now makes it possible to detect a wide range of viral genotypes with a high degree of sensitivity [23]�C[29]. The aim of this study was to reevaluate the archival specimens from this global cohort, supplemented by 47 additional archived WHO specimens that were not previously tested, for the presence of rotaviruses and noroviruses.
Furthermore, we examined the geographical distribution of previously circulating viral genotypes, while using phylogenetic analyses to assess genomic variation and evolution over a span of more than three decades. Our data confirm the predominance of the rotaviruses that launched concerted vaccine development efforts soon after their discovery, but show also an early underestimation of noroviruses as serious pediatric pathogens. This retrospective approach to rotavirus and norovirus molecular epidemiology and evolution provides insight for the prediction of epidemiologic trends that are relevant to the development of efficacious vaccines for viral gastroenteritis. Methods Study Cohort and Specimens Diarrheic stools from 483 infants and young children and 2 adults from the following regions were tested for rotaviruses and noroviruses: Central African Republic, French Guiana, Senegal, Uganda, China, South Korea, Malaysia, Sri Lanka, Tunisia, Democratic Republic of the Congo, and Singapore (Table 1).
Collection dates ranged from 1976 to 1979, and ages of individuals, reported for 312 children, ranged from 3 weeks to 14 years old, with the majority between 3 weeks and Batimastat 3 years of age (n=284). Hospitalization status was reported for 266 of 483 children; 259 (97.4%) of the 266 children were hospitalized.
4, E and F) Blockade of L-type calcium channels results in a red
4, E and F). Blockade of L-type calcium channels results in a reduction selleck chemical Wortmannin in phosphorylated ERM in mouse islets and in MIN6 cells in response to a glucose challenge (10 min) (Fig. 4, A�CD). Concomitant with the general increase in phosphorylated ERM in response to glucose stimulation, an increase in the abundance of phosphorylated ERM at the periphery of MIN6 cells was found by immunofluorescence. This increase in abundance of phosphorylated ERM at the periphery is blocked by the addition of nifedipine (Fig. 4G). Phosphorylated ERM was also imaged in low glucose by optical z-sectioning confocal imaging and presented as a tilting volume reconstruction movie (Supplemental Movie 3). Through this method, we observed that the appearance of active ERM is punctate along the membrane and at the interface between cells.
These results indicate that glucose stimulation of islets and MIN6 cells results in an increase in [Ca2+]i, which in turn leads to an increase in the abundance of active ERM at the membrane. Fig. 4. ERM proteins are phosphorylated in islets and MIN6 cells in response to glucose stimulation in a calcium-dependent manner. Islets (A) and MIN6 cells (C) contain significantly more phosphorylated ezrin (top), radixin (middle), and moesin (bottom) (Thr … Glucose leads to translocation of ezrin and radixin to the cell periphery which is dependent upon COOH-terminal phosphorylation. To determine the kinetics of translocation of radixin-Cherry, we transfected radixin-Cherry into MIN6 cells and stimulated those cells with 20 mM glucose.
In response to high glucose, radixin-Cherry translocates to the cell periphery (Fig. 5A) in a similar manner
Sustained pancreatic beta-cell death, which mainly occurs by apoptosis, ultimately leads to diabetes mellitus [1]�C[3]. Apoptosis follows an autoimmune process called insulitis that involves secretion of a number of pro-inflammatory cytokines by activated inflammatory cells including interleunkin-1beta (IL-1��), tumor necrosis factor alpha (TNF-��) and interferon gamma (IFN��) [4]�C[6]. It has been shown that exposure of beta-cells to these cytokines is sufficient to induce apoptosis [3], [4]. The c-Jun N-terminal Kinases (JNKs), also known as stress-activated protein kinases (SAPKs), are potently activated by pro-inflammatory cytokines and have been involved in cytokine-mediated beta-cell apoptosis [7]�C[9].
Three JNK isoforms have been identified: JNK1, JNK2, and JNK3. JNK1 and JNK2 are ubiquitously expressed, while JNK3 was found to be restricted to the brain and testis [10], [11]; we however Brefeldin_A recently described high expression and functional role of this isoform in pancreatic islet cells [12]. Despite their high structural homology, the JNK isoforms have distinct biological functions. Genetic disruption of Jnk1 is associated with insulin resistance and obesity [13], while Jnk2 disruption partially protects Non-Obese Diabetic (NOD) mice from destructive insulitis [14].
(1)All the solutions employed in this work were prepared with 18M
(1)All the solutions employed in this work were prepared with 18M? Perifosine 157716-52-4 cm water produced and purified in a Reverse Osmosis System (Puritech model RO 300). Electrochemical studies were conducted by using 0.5mol?dm?3H2SO4 (Sigma-Aldrich) as the supporting electrolyte. The electrochemical experiments were carried out in a one-compartment cell with a main body of 30mL. The working electrode was prepared by starting from a black ink consisting of 1mg of the catalyst, 5��L Nafion (Sigma-Aldrich), and 95��L ethanol, then; the solution was placed in ultrasonic bath for a period of 20 minutes, followed by deposition from a micropipette onto a freshly polished glassy carbon substrate and the drying in oven at 60��C for 20 minutes.
The carbon electrode was utilized as counterelectrode, and an Ag/AgClsat reference electrode was employed and positioned close to the working electrode. The electrochemical activity of the catalysts was assessed by chronoamperometry in the presence of glycerol (Sigma-Aldrich) 1.0mol?dm?3 at 400mV versus Ag/AgClsat for 2 hours. The electrochemical experiments were performed using an AUTOLAB potentiostat/galvanostat model 302N.3. Results and DiscussionThe representative TGA and DTA curves obtained for the C/Pt-Sn-Ni-Me catalysts are presented in Figure 1. This technique monitors the mass loss of the catalyst as a function of the temperature. The results show that there is mass reduction beginning at ca. 87��C, with total mass loss of ~60% for all the investigated catalysts. Moreover, there are two other mass loss processes: one localized at ca.
~245��C and the second located at ca. ~320��C, which continues until ca. 350��C. Thereafter, the mass remains practically constant. These processes are associated with the thermal decomposition of the polymer formation. The TGA study helped the monitoring of three parameters of the catalyst. Firstly, it aided in the selection of the calcinations temperature range (350 to 450��C), in which there was no change in the mass of the catalyst. Secondly, it indicated the temperature 350��C at which all the organic compounds had been removed. Finally, it helps establish the lower temperature at which the smallest particle size is ensured, in order to increase the surface area and consequently promote greater catalytic efficiency.Figure 1TGA curves obtained for the C/Pt60Sn10Ni10Ir20 catalysts at a heating rate of 5��C min?1 from room temperature to 550��C.
Figure 2 shows the XRD patterns obtained for the different Pt-based electrocatalysts prepared at 350��C for 3 hours. All the catalysts display a smooth peak at �� = 24.3��, attributed to carbon with the reflection plane (002). The AV-951 other peaks are characteristic of the structure of the face-centered cubic (fcc) structure of metallic platinum and refer to the reflections planes (111), (200), (220), (311), and (222) [15, 16].


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The Kit x Smirnoff
Get the Summer Vibes Going with this Picnic-Ready Y2K-Inspired Clothing Line
An adorable bucket hat that doubles as an ice bucket? Yes, please.
Quick-drying nail polish. Makeup that also delivers skincare benefits. Stackable makeup brushes. We can't get enough of cute products that are also super functional and make our multi-tasking constantly-on-the-go lives a little more seamless.
The next natural step? Wardrobe pieces that effortlessly give off cool vibes while also serving a higher purpose, obviously.
Photo: Smirnoff
Enter the Very Berry Cool Clothing Line, the latest collab between irreverent Canadian designer Hayley Elsaesser and Smirnoff. Dripping with on-trend Y2K nostalgia, the limited-edition summer-ready collection (which also happens to be unisex, FYI) includes three delightful pieces that are perfect for picnic and patio season: a cherry-print bucket hat, a classic tee and colour-blocked cargo pants.
But that's not all. The line is inspired by the brand-new Smirnoff Vodka & Soda Berry Blast, a refreshing sparkling bevvy that tastes of a bright blend of cherry, citrus and blue raspberry. (It's also sugar- and carb-free, coming in at only 90 calories per can.) Both the bucket hat and cargo pants are lined with a coolant material, making them perfect to transport your Berry Blast cans while keeping them ice cold. Use the hat as an ice bucket or pop some cans into the pockets of the cargo pants, and you're good to go.
"As any Canadian who grew up in the '90s and early 2000s, I'm a huge fan of summer and Y2K style, so bringing those two inspirations together to celebrate the delicious Berry Blast was a match made in heaven," Elsaesser said in a press release. "When producing this collection, we were very conscious of choosing high-quality, size-inclusive, made-to-last fabrics, along with reducing waste during the pattern making process."
This content was created by The Kit; Smirnoff funded and approved it.
By Jenna MacGregor
The CAFA 2022 Nominees Are Official! Here Are a Few We're Most Excited About
Celebrating the best of Canadian fashion and beauty
CAFA returns! The Canadian Arts & Fashion Awards, which recognize and promote our country's most exciting fashion and beauty talent, are officially back in full in-person force after two years of pandemic-related complications. This week, 85 nominees were announced in 17 categories. Then, on October 15, hundreds of designers, stylists, makeup artists, models and content creators will descend on the Fairmont Royal York for the gala, where…


A good way to draw attention to your products or business is through social media marketing. However, a thorough knowledge of the subject is required in order to make it work. The information below will inform you on all the latest social marketing trends that will help you master the skills necessary to be a social marketing guru!
Create a strategy prior to starting with social media marketing. Decide who will be in charge of managing the pages, the kind of layout you desire and the amount of time you are interested in investing in it. Set up a timeline and budget for your media marketing. To succeed, stick as closely as possible to your plan.
All social medial profiles should have buttons included, along with RSS feeds of any updates you would like people to see. Add it to your comments signature. Provide multiple links on any social networks sites you have to make it easy for customers to find you.
Use tools related to Twitter such as Tweepi or Twellow. Tools, such as these, let you easily locate consumers who you are trying to target, which helps save you lots of time. By creating a Twitter account, you can have a list of followers that you can use as a foundation for your client list.
Write new posts on Twitter as often as possible so that your updates do not get buried in your followers' feeds. With Twitter it is very much about volume and quality. You need to post often. Using short posts, you can create more updates from a single event.
Remain somewhat flexible to the schedule of page updates. If you are about to release a new product, keep people informed via social networks. If you are having a hard time coming up with new content, you may want to post less often.
Blogs written by actual employees are a great way to provide content to your customers which is informative and entertaining. These blogs offer added value to site visitors and also improve your relationship with existing customers. This serves as a window into your business' culture, atmosphere and operations that are used to provide the products and services your clientele come to you for. Letting customers see what goes on inside is a great way to get them to put more trust into your business.
Hold a photo contest to get your customers' interest in your social media site. Have users submit an interesting photo that includes your product and offer a prize for the best one submitted. They will share these photos with others in their networks who might not know who you are and expose you and your company to new markets.
This entry was posted in Computer And Tech Advice and tagged social marketing, social media marketing, social networks by Computer Education World. Bookmark the permalink.


Earrings look good, good quality.
Baby, good, better installation....After the opening, there is no less, and the quality is good, it is recommended.
Received, good, good workmanship, packaging is very good, there is no damage, the price is very affordable.
Just posted today, try the effect.
Baby, good, better installation. The letter posted up wallcloth.


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What is the guru prayer?
August 2, 2022 By Michael Simons Recommendations
What are the 8 manifestations of Guru Rinpoche?
What is guru mantra?
How do you worship a guru?
How do you pray to Jupiter?
How do I get guru grace?
How long did Guru Rinpoche meditate for?
I Bow down to that great Guru, Who is the essence of all living and nonliving things. Which pervades in the whole universe creation, moving and unmoving. To that benevolent Guru(spiritual guide) who showed me the true state of being, I bow down.
Elucidation of the Eight Manifestations:
Shakya Senge, "Lion of the Shakya clan"
Pema Gyalpo, "Lotus King"
Nyima Odzer, "Rays of the Sun"
Dorje Drolo, "Vajra Comforter of Beings"
Senge Dradog, "Roaring Lion"
Lodan Chokse, "Guru Possessing Wisdom/Highest Aspirations"
Pema Jungne,
What does Guru Rinpoche mean?
the Precious Guru
Guru Padmasambhava, also known as Guru Rinpoche (the Precious Guru), is an important figure in Buddhism who was instrumental in establishing Vajrayana Buddhism in Tibet around the 8th century CE.
Who prophesied the birth of Guru Rinpoche?
Guru was born 3,060 years ago in the Fire Monkey Year, 12 years after Buddha attained parnirvana in accordance with Buddha's prophesy.
A guru mantra is one that a guru gives to a disciple, who then chants the mantra for his/her spiritual growth. Derived from Sanskrit, gu means "darkness"; ru means "remover"; man means "to think"; and tra means "liberate." The guru, therefore, is a remover of darkness, and the mantra is a means to liberation.
How Do You Worship Guru Bhagawan?
Respect and assist the poor and disadvantaged.
Donate food for those who are in hunger.
Respect and be grateful to the teachers in your life (Mother, Father, Teachers, Idols, Mentors and etc.)
Provide educational or financial assistance to students.
Donate food to cows.
Who is Chana Dorje?
Chana Dorje (also known as Vajrapani) is one of the 8 "important" Bodhisattvas and is the god of power and energy, rain and thunder, and snakes. Chana Dorje also protects people from the Naga, which are beings found in lakes and rivers and make people sick.
What is a Terma in Buddhism?
Terma (Tibetan: གཏེར་མ་, Wylie: gter ma; "hidden treasure") are various forms of hidden teachings that are key to Vajrayana and Tibetan Buddhist and Bon spiritual traditions. In the Vajrayana Nyingma school tradition, two lineages occur: an oral kama lineage and a revealed terma lineage.
According to astrologer, applying saffron tilak on the forehead will also be beneficial for the happiness of Jupiter. Take a bath by adding a pinch of turmeric in water on Thursday. During this, keep chanting the mantra "Om Namo Bhagwate Vasudevaya". Keep fast on Thursday and worship Lord Vishnu methodically.
A guru's grace is essentially a channel for experiencing the divine. In order to experience this, a devotee must surrender completely to the guru, offering pure and unconditional love.
Who is Vajrapani?
Vajrapani, the "holder of a thunderbolt" (vajra), shares his origins with the Vedic deity Indra, god of storms. Early in Buddhist iconography, the thunderbolt scepter assumed an independent meaning associated with clarity of pure thought leading to enlightenment.
What does Om Vajrapani hum mean?
Vajrapani is an enlightened Buddhist deity, or Bodhisattva, who embodies the infinite energy of the liberated mind. Through recitation of the mantra "Om Vajrapani Hum", one can learn to access the boundless and fiery energy which Vajrapani emits.
The Taktsang Monastery, also known as the 'Tiger's Nest', in Bhutan, was built in 1692 around a cave where the great Padmasambhava (Guru Rinpoche) meditated for three years.
What did Joseph John Thomson discover?
What is Rhinocerebral disease?


Thomson Reuters Elite, part of Thomson Reuters Legal, today announced that long-time client Steptoe & Johnson PLLC has become the latest firm to select 3E® as its technology-driven practice and financial management platform for the future. The 3E deployment will enable the firm to replace its Enterprise™ system and other solutions it currently relies on to manage workflows, reports, and more. 3E is an integral component of the Elite Enterprise Business Management Solution, an end-to-end system built to help firms manage all operational aspects of the business.
Steptoe & Johnson is a leading business, litigation and energy law firm with over 400 timekeepers across offices throughout the US. Chosen after a thorough market review, 3E won out over the competition due to its superior technology and the confidence Steptoe & Johnson has in Elite due to their existing relationship.
Steptoe & Johnson PLLC is a U.S. law firm with more than 300 attorneys and core strengths in energy, business, employment, and litigation. Steptoe & Johnson operates 13 offices in six states including Colorado, Kentucky, Ohio, Pennsylvania, Texas, and West Virginia. Visit http://www.steptoe-johnson.com and connect on Twitter and LinkedIn.


Master the Mechanical Aptitude & Spatial Relations Tests provides the key to test-prep success on exams measuring spatial relations, symbol reasoning, and mechanical aptitude for training and employment opportunities in the military, civil service, technical schools, and private industry. Featuring practice questions covering all major exam topics-including hidden figures, tool knowledge, and mechanical insight-with overviews of concepts that appear on mechanical aptitude/spatial relations exams, such as visual-motor coordination and pattern analysis. The book also includes detailed subject reviews, along with charts and diagrams to illustrate answers.


When Helen Clay Frick began amassing material for an art reference library in the 1920s, she had a vision of documenting every work of art in the western world and making the visual record accessible to a community of art researchers and the public. Her vision seems presciently 21st century, as today, images and catalog records from the Frick Collection's Photoarchive are now digitally available to the public free of charge through an online interface -- the NY Art Resources Consortium online catalog, Arcade -- which unites the collections of the Frick Art Reference Library and the libraries of the Brooklyn Museum and The Museum of Modern Art and allows users to search through a unified interface.
The contents of the Photoarchive reveal an inquiring, curious, and encyclopedic mind: Helen Clay Frick wanted images not just of the paintings, sculpture, and architecture of the western canon, but of unpublished and little known works in private homes in the United States and Europe. Traveling to Europe in 1920, she saw the devastation to cultural heritage from World War I, and began compiling before-and-after shots to document the damage. She hired agents and employed professional photographers in Europe to document artwork in museums, private homes, and at auctions. One of these, a portrait of the Drummond family at Cadland (England), painted by Johann Zoffany (1733-1810), was photographed at a sale at Christie's in London in 1924 and was later destroyed during the London Blitz in 1940 (see image in gallery). The Frick image is the only visual record of the painting. Between 1922 and 1967, in an effort known as "the American campaigns," her team of photographers discovered (and photographed) examples of fine art and folk art in private homes and small public institutions across the U.S. Many of these were early American portraits, such as the anonymous mid-19th century painting of the Gilbert sisters, held by a descendant of the subjects (see image in gallery); most of them are unique and are not documented in any other source.
Two NEH awards through the Division of Preservation and Access's Humanities Collections and Reference Resources grant program have provided public access to this critical catalog: The first, awarded in 2009, digitized 15,000 deteriorating negatives, most of them from the American campaigns. A second award made in 2011 continues the work of the earlier award. When complete, the project will have digitized and made freely available online all of the Library's original large-format, black-and-white glass plate, acetate, and nitrate negatives (totaling approximately 30,000).
Information and images from U.S. and European auction and exhibit catalogs from the 18th century to the present were entered into the archive and are today an essential tool for art historians, students, and art market professionals undertaking provenance research. The archive continues to be an important source to facilitate the restitution of lost or stolen works of art in international legal cases.
A selection of Paris exhibition pamphlets from the 1920s and 1930s along with an example of one of the Frick Art Reference Library's "faux catalogues," consisting of a typed checklist and newspaper reviews, for a 1943 exhibition at Wildenstein Gallery in New York.
Photograph of Francesco Guardi's painting, The Island of San Giorgio. The painting was photographed by A.C. Cooper (London) in the sale at Christie's, London on June 26, 1925, lot 117.
For scholars who study social history or the history of collecting, the reference images are critical primary source material, since they reveal the tastes and habits of collectors, and the material culture of individuals, classes, and regions that may not be documented in any other source. The archive is used by researchers and the interested public to chart changes in the condition of an artwork over time, or view a work of art that has since been lost, stolen, or destroyed. It is also used to document the careers of little-known American artists, or fill in gaps in knowledge about a work of art's long (and at times treacherous) journey from artist's studio through dealer to private owner, thief, or museum exhibit.
It is perhaps the uses of the archive for online genealogical research that highlights the broad public appeal of the resource. Imagine their surprise when a couple from Pennsylvania conducting genealogical research discovered through an online search the records for two Frick negatives of portraits of the wife's ancestors. The portraits of Mr. and Mrs. Philip Eisenbrey were painted by Jacob Eichholtz in 1828, and were photographed in 1959 by a staff photographer at an exhibition at the Pennsylvania Academy of the Fine Arts (see image in gallery). The couple was able to fill in some blanks on their genealogical chart and the Frick was able to update the ownership records for the image.
Photograph of back of Francesco Guardi's painting, The Island of San Giorgio. The back of the painting was photographed by A.C. Cooper (London) in the sale at Christie's, London on June 26, 1925, lot 117.
Photograph of the title page of 1925 Christie auction catalog. Title page of the auction catalog in which the Francesco Guardi painting, The Island of San Giorgio, is listed.
The Library is always updating its records and invites users with additional information about images and records to contribute to the archive. See the Photoarchive (link no longer exists) for more information about how you can contribute to creating more accurate records for research. If you are interested in the European agents who contributed photographs that helped build up the archive in its early years, see the list of agents here.
The catalog records may be accessed elsewhere besides Arcade. Images are available through the Frick Digital Image Archive and image records (though not images themselves) are available through the Frick's own online catalog, FRESCO. And 25,000 images have also been uploaded to ARTstor, where they are available by subscription.
The projects mentioned in this article have been awarded through the NEH Division of Preservation and Access's Humanities Collections and Reference Resources grant program: PW-50310-09 and PW-50778-11.