text:
The Greatest Video Game Comeback Of My Life
Yannick LeJacq
Filed to:blizzard
ggheroes of the stormmobasrektthe comeback is real
"This team sucks," the Raynor player quipped once again. "I want to quit," he added a moment later. All I kept hearing was: I have the power to make your life miserable for the next twenty or thirty minutes, and I'm going to. But I wasn't going to let him.
Once the game starts to get away from you, playing a match of a highly competitive MOBA like Heroes of the Storm or League of Legends can start to feel like you're trapped in a subway car with the most virulent type of internet troll. They might start insulting you. Or they could moan and groan and stomp their feet in a more general fashion. During a recent Heroes match that I played, two of my teammates started to do both of these things at the same time.
I was playing very badly. We all were, really. Within five minutes the enemy team had established a strong lead, remaining consistently two levels ahead of us. This meant by the eight-minute mark, our opponents had already reached level 10. That's the moment when each character on a HOTS teams unlocks their ultra-powerful "heroic abilities." We were still at level 8. That's when the person playing Jim Raynor, a soldier from the StarCraft universe, and our Malfurion, an elf from Warcraft lore, decided to start crapping on all of us.
I wanted to prove them wrong. But instead I just kept dying.
Every time I looked down at the splayed-out corpse of Anub'arak, the large red beetle hero I was playing that you can see in these videos, his dead body gleamed like an unpleasant reminder. Whispering to me in an eager growl: Yes, these people are correct. You really do suck.
Defeats are never a pleasant thing to experience. But moments like these — when one or more of your teammates starting venting their rage on whoever or whatever will take it — are the only thing in Heroes that actually feels defeating. Once our Malfurion started bemoaning the way the game was going, I knew that winning wasn't going to only be an uphill battle against the mechanical gameplay odds we were facing — the fact that we were underpowered compared to our enemies, the way they had diced through our outer defences leaving little more than a thin tissue between themselves and the heart of our base.
Securing a victory would also mean trying to revive our team's forlorn spirits — right when two of us were doing their very best to make that impossible. Even when we managed to pick off one or two or our enemies, they wouldn't let up. "We don't even need our team," Malfurion jabbed after he and another teammate managed to kill someone. A moment later, we were all dead again.
Normally when I've come across people like this particular Raynor or Malfurion, I've called them out for their destructive negative attitudes. I've even indulged my own ugly tendencies and lashed out at people in retaliation. And I almost started to help them pick a fight in this game, typing: "Thanks for your contributions." It was the snidest remark I could think of.
But then I stopped, and decided to do something different. I decided to shut up, grit my teeth, and just keep playing the game, no matter what happened.
Somehow, we managed to take out the enemy team's Rehgar, a wolf-man-type hero from the Warcraft universe, while they were pushing hard against our last line of defences:
The surviving opponents started to run away. I noticed Valla, a live dual-crossbow-wielding assassin from Diablo, was low on health. I lunged towards her and didn't stop chasing.
Looking back, that wasn't a wise move. I was isolating myself from my allies, which was the same error that had kept getting us killed the whole beginning of the match. But it was so late in the game and our defeat was so seemingly probable that I didn't care. I just wanted to get the kill, to make her pay.
I should have died. But something incredible happened when I chased Valla across the map:
I managed to kill both of the enemy assassins with the help of Malfurion — the player I'd grown to detest over the course of knowing him for fifteen minutes or so. Suddenly, the guy started to sound a very different tune.
"OK guys," he typed. "We can make a comeback. Just don't engage dumbly." We scrambled to capture two mercenary camps, sending the hellish monsters we'd overpowered to attack the enemy base for us. Then we ran back towards the gigantic angle and demon fighting at the center of the map. These are the two "Immortals" you're supposed to help or hurt in this specific HOTS map, depending which side you're on. The first team to kill the opposing Immortal gets rewarded with the big angel (or demon) jumping into the main battle and attacking the enemy base.
The Immortal was our only chance to turn things around. I died again when trying to take theirs down, losing myself to tunnel vision once again and not noticing the enemy team walking up behind me. But Raynor held them off until we could regroup.
Once we had the Immortal down, it was all or nothing. Too risky to bet that we'd manage to turn things around again if we didn't manage to win the game right then and there. We had to make one final push:
It's odd to rewatch this game after it ended. I played much more clumsily than I remembered. Not during the beginning portion of the game — obviously that was bad. But during those triumphant moments that felt so spectacular in the moment. Taking out Valla and Nova, and feeling like I'd bought my team a second chance at life. Looking back, I was still faltering, still making mistakes even as my team began to rebound. I wasn't paying close enough attention to my surroundings, focusing entirely on the single target at hand that I'd chosen in my fit of desperation.
That's what makes a comeback like this feel so amazing, though, and what makes Heroes of the Storm so special. It's tempting to always focus on the superhuman feats that professional eSports players can accomplish. But what's revolutionary about MOBAs is the fact that they give everyone who plays them a chance to achieve something.
Something that feels truly great, even if just for a moment.
ashigaru says:
Yeah that moment when your team engaged in a 3v5 when you and Gazlowe weren't there was special… Also gazlowe is such a crap champ, bl being stuck with him!
Good work turning it around, too often people throw in the towel and give up 😀
spyder says:
Really enjoying these Heroes anecdotes! My experience with MOBAs is limited exclusively to Smite on the Xbone, but it seems like the meta generally translates across titles. Also, good to see even more experienced players have a bad start!
Slightly off topic; any seasoned MOBA players care to weigh in on the learning curve, say, from playing Smite to attempting to jump into Heroes? I really like the 3rd person view in Smite, so I'm wondering whether the top down is that much of a leap to get used to…
rakunado says:
There is no greater feeling in HOTS then winning when you are down. That feeling of helplessness at the beginning when the opposing side hits 10 while you are two levels down. That feeling of the weighted boot descending on your behind. That feeling when you just concentrate on your game and play to the best that you can. Then suddenly… you see that light. Just a glimmer but enough to give you hope. Your team also begins to see it. There is hope. There is a lot of hope. Even if my side loses those type of games in the end, everyone generally leaves positive with pats on the back and praise for each other for holding it together down to the last second. I had fun, and if we did win, its a bonus. 😀
Another personal blog entry from this guy, if its not hots its crying about something to do with LoL.
dashals says:
All about dem map objectives. Doesn't matter how far ahead they are if you managing to group up and dominate one map objective. Also helps if you then smash every merc camp on the map. I always fall back on that. Splits them up trying to defend against mercs when important map objectives pop up.


text:
is a 1975 Japanese film in Nikkatsu's Roman porno series, directed by Akira Katō and starring Kumi Taguchi.

Plot
After the director's message, "I visualize the romance of Roman Porn and I attempt to share that image," a loosely connected series of softcore sex scenes unfolds. The plot concerns Kyoko (Kumi Taguchi), a young Japanese woman married to a man in France. When he abandons her, she returns to Japan. With her sexual appetite now at a high pitch, she engages in sexual escapades with a wide assortment of people, including old friends, both male and female, and an entire soccer team.

Cast
 Kumi Taguchi as Kyoko
 Fujio Murakami
 Naka Fuyuki
 Mitsuko Aoi
 Namio Sokame
 Mitsuyasu Maeno

Background
Director Akira Katō was a competent, but not highly successful member of the Nikkatsu Roman Porno team. His Crazy for Love (1971) was part of Nikkatsu's second Roman Porno double-release, and he stayed with the studio throughout its 17-year production of the series. Tokyo Emmanuelle was Katō's first successful film. Later well-regarded films by the director include Slave Wife (1976) and Momoe's Lips: Love Beast (1980).

Tokyo Emmanuelle has some notoriety for one of the supporting actors in its cast. This was the first billed film appearance of Mitsuyasu Maeno. Maeno made international headlines in March 1976 when he died in a kamikaze attack on Yoshio Kodama, a multi-millionaire right-wing leader and leading figure in the Lockheed bribery scandals. In this film he made love to the lead actress while flying a plane. In the years after Maeno's death, his Roman Porno appearances attracted a cult following among enthusiasts of the genre.

Tokyo Emmanuelle made an appearance in Chilean writer, Antonio Skármeta's 2003 novel, The Dancer and the Thief. In the novel, lead character, Ángel meets his love interest in front of a Japanese movie theater. The poster advertising Tokyo Emmanuelle becomes a point of connection between the two.

Critical appraisal
In a contemporary review, the Monthly Film Bulletin stated that "the continuity is sometimes choppy" and that "the film has been designed and shot with enough surface gloss to ensure that in this soft-core package tour, at least the packaging looks tolerably fresh"

In their Japanese Cinema Encyclopedia: The Sex Films, the Weissers note that the film's plot is a weak construct designed only to give lead actress Kumi Taguchi opportunities to appear nude. They also note that this is not a bad thing. The nude Taguchi seen horseback riding on the beach and riding a porpoise are highlights of this good-looking film, according to the Weissers. The lack of good plotting, however, harms the film. "With just a bit of creativity, they write, "this could have been a great pinku eiga instead of a trendy Penthouse-ish pictorial."

Pink film scholar Jasper Sharp writes that the film appealed to the taste for the exotic in both Japanese and Western audiences. For the Japanese audiences, the association with Emmanuelle Arsan's novel Emmanuelle and the 1974 film based on it, gave the film a touch of class. For Western audiences, the interest of a distant country was an attraction. Both Japanese and Western audiences, writes Sharp, were able to appreciate Kumi Taguchi's "well-proportioned figure and smouldering dark looks".

Availability

Tokyo Emmanuelle was released theatrically in Japan on July 1, 1975. It was unusually widely circulated for Nikkatsu Roman Porno film. It was released in Germany under the title Wilde Emmanuelle im Paradies der Lust. In 1977 Tokyo Emmanuelle became the first of Nikkatsu's Roman Porno films to be distributed in Britain, when the exploitation studio Intercontinental released the film under the title Emmanuelle in Tokyo. Under the title Tokyo Emmanuelle, it was also playing in Canadian theaters in mid-1977. It was also released in Hong Kong by the Shaw Brothers.

Tokyo Emmanuelle was released on VHS in Japan on August 10, 1988 and re-released in December 1994.

Bibliography

English

Japanese

Notes

1975 films
1970s Japanese-language films
Nikkatsu films
Nikkatsu Roman Porno
1970s Japanese films

redpajama_set_name: RedPajamaWikipedia


text:
Jürgen Janke (* 18. Dezember 1948 in Bremen) ist ein Bremer Beamter und war Politiker (SPD) sowie Mitglied der Bremischen Bürgerschaft.

Biografie

Familie, Ausbildung und Beruf
Janke war verheiratet und hat eine Tochter.

Er absolvierte in Bremen eine Ausbildung beim Finanzamt und arbeitete dort bis 1978 – zuletzt als Steueramtmann. Nach seiner Abgeordnetenzeit war er kaufmännischer Geschäftsführer des Überseemuseums Bremen und dann beim Senator für Inneres, Kultur und Sport in der Kulturabteilung als Oberamtsrat tätig. 2009 wurde er pensioniert.

Politik
Janke ist Mitglied der SPD und war in seinem SPD-Ortsverein in Obervieland im Vorstand aktiv.

Von 1979 bis 1995 war er mit Unterbrechungen rund 15 Jahre lang Mitglied der Bremischen Bürgerschaft. Er war zwischenzeitlich auch Mitglied des Beirats Obervieland und in verschiedenen Deputationen und Ausschüssen der Bürgerschaft tätig u. a. in der Sportdeputation. Einer seiner politischen Schwerpunkte war der Datenschutz, von 1983 bis 1987 war er Vorsitzender eines Ausschusses der Bürgerschaft, der eigens für dieses Thema eingerichtet worden war.

Weitere Mitgliedschaften
 2002 bis 2009 war Janke als Vorstandsmitglied der Stiftung Wohnliche Stadt vom Bremer Senat berufen und mit den Verwaltungsaufgaben der Stiftung betraut.
 Er war Vorsitzender des Sportvereins VfB Komet in Obervieland.

Quellen
 Norbert Korfmacher: Mitgliederverzeichnis der Bremischen Bürgerschaft 1946 bis 1996 (= Kommunalpolitik. Band 1). LIT, Münster 1997, ISBN 3-8258-3212-0.

Einzelnachweise

Mitglied der Bremischen Bürgerschaft (ab 1945)
SPD-Mitglied
Deutscher
Mann
Geboren 1948


text:
Q: "Calculate" button on decimal to/from binary calculator doesn't respond This is my first term in programming, just got to GUIs.
Context: I built a JFrame with North, Center, and South border layout. In the North are radio buttons for decimal -> binary and binary -> decimal; that part works fine. In the Center panel are a decimal JTextField (decimalField) and a binary JTextField (binaryField); those appear correctly and receive input. In the South panel are Calculate and Clear buttons. Clear works fine, but
Problem:
When a number is entered into, say, decimalField and the JButton btnCalc is clicked, nothing happens.
I am specifically using an anonymous inner class to distinguish this button from others for pedagogical reasons.
Is it a syntax problem?
btnCalc.addActionListener
(
    new ActionListener()
    {
    @Override
    public void actionPerformed(ActionEvent e)
    {
        if(e.getSource() == decimalField)
        {
            String textDec = decimalField.getText();
            binaryField.setText(Integer.toBinaryString(Integer.valueOf(textDec) ));
        }

        if(e.getSource() == binaryField)
        {
            String textBin = binaryField.getText();
            decimalField.setText(Integer.toString(Integer.valueOf(textBin, 2) ) );
        }
    }
}

);
Searched internet for similar examples. Couldn't find anyone using anon inner classes for this type of problem, and other examples do not help me solve it with this approach.
Advice on how to troubleshoot is also welcome. It seems like the most important skill in programming.

redpajama_set_name: RedPajamaStackExchange


Experience nature close-up, with breathtaking views and unforgettable impressions away from the crowds.
With snow-shoes, you can explore the untouched nature away from the pistes and gather unique impressions. Tours in varying degrees of difficulty and lengths are available. The routes are generally well signposted and therefore ideal for all levels of fitness.
What's more, there will be plenty to keep body and soul united on your snow-shoe walks, as our mountain lodges offer you selected regional delicacies to keep up your strength. You are certain to find a shop that hires out snow-shoes close to you.
The snowshoe walks are offered by the local sports equipment shop Sport Rettensteiner in Forstau. The snowshoe walks take you to places you would never be able to reach on skis.
In the midst of the snowed-in mountain scenery the snow crunches beneath your feet every step through untouched nature. Walk on age-old paths, just like the miners centuries ago: an incomparable experience.
Walk with snowshoes on your feet and telescope hiking poles through the virgin snow and enjoy the pristine winter countryside.


text:
RIA Novosti website group:
en.rian.ru
R-sport
Trial & Litigation
Corruption & Bribery
Appeals against sentence of nine terrorist group members set for September 25
18:22 19/09/2019 The Supreme Court of Russia will consider appeals against sentence of nine members of Hizb ut-Tahrir terrorist organization banned in Russia on September 25.
Russia's culture official charged with fraud
15:06 19/09/2019 Deputy Director of the Culture Ministry's department on the state protection of cultural heritage Pavel Mosolov has been charged with large-scale fraud.
Copyright infringement suit against IKEA dismissed by Moscow Region court
14:54 19/09/2019 A court in Khimki, a town in the Moscow Region, has dismissed a copyright infringement lawsuit against the Swedish furniture corporation IKEA.
Ex-chair of republican election commission gets 6 years for bribery
13:50 19/09/2019 Ex-chair of the election commission of Russia's Republic of Komi Yelena Shabarshina has received 6 years in colony for taking bribes.
Prosecutors seek to release actor jailed in Moscow rally case on travel restrictions
12:40 19/09/2019 The Prosecutor General's Office has filed a motion to release actor Pavel Ustinov, an alleged participant of riots during a Moscow unauthorized rally, from detention on travel restrictions until his case is considered by an appeals court.
Russian business ombudsman pushes for creation of blacklist of judges
11:35 19/09/2019 Russia's business ombudsman Boris Titov proposes to set a special expert group to assess judges' decisions and rulings and create the so-called blacklist of Russian judges.
Journalist convicted of inciting terrorism, extremism freed from Russian prison
10:44 19/09/2019 Journalist Boris Stomakhin, who had been convicted of inciting terrorism, was released from prison in a Saratov Region on Thursday morning.
May 2019 June 2019 July 2019 August 2019 September 2019
No referendum required to amend Russia's Constitution – rights advocate
17:13 17/01/2020 The renewal of the Constitution proposed by Russia's President Vladimir Putin requires neither a referendum, nor convening of the Constitutional Assembly, a member of the Presidential Council of Human Rights Alexander Brod has stated.
Moscow court to hear case over $950 mln embezzlement in BTA Bank on January 31
15:31 17/01/2020 The Moscow Tagansky District Court is to hear a criminal case against ex-Chairman of the board of directors of Kazakh BTA Bank Mukhtar Ablyazov, charged with embezzlement of over 58 billion rubles (about $950 million) of the bank's controlled structure.
Ex-top official of regional penal colony convicted of $300k embezzlement
16:09 17/01/2020 A court in Russia's Saratov Region has sentenced a former head and a former chief accountant of one of the local penal colonies to 4 and 3 years in custody respectively for embezzling over 18 million budget rubles ($300,000).
Russian Economy Minister Ulyukayev charged with bribery
IKEA's slippery slope in Russia
Russian antimonopoly watchdog probes Microsoft upon complaint from Kaspersky
Russian communications regulator starts blocking LinkedIn
Photo: The Navalny brothers sentenced in Yves Rocher case
Photo: 2012 Bolotnaya protesters found guilty
Photo: Bolshoi soloist Dmitrichenko on trial for acid attack
Infographics: What changes lie in store for non-profit organizations
Copyright © RAPSI All rights reserved.
RAPSI news is registered by the Federal Service for Supervision of Communications, Information Technology, and Mass Media (Roskomnadzor).
Registration certificate ИА № ФС77-57654 was issued on April 8, 2014.
Some material may be inappropriate for children under 12

redpajama_set_name: RedPajamaCommonCrawl


text:
Duo Xu
Postdoctoral Scholar, Biochemistry
Doctor of Philosophy, University of California Los Angeles (2019)
Master of Arts, Washington University in St. Louis, Chemistry (2014)
Bachelor of Science, Jilin University, Chemistry & Biotechnology (2012)
Stanford Advisors
Peter Kim, Postdoctoral Faculty Sponsor
xuduo@stanford.edu
University - Scholar Department:&nbspBiochemistry Position: Postdoctoral Scholar
Designing epitope-focused vaccines via antigen reorientation. bioRxiv : the preprint server for biology Xu, D., Li, C., Utz, A., Weidenbacher, P. A., Tang, S., Sanyal, M., Pulendran, B., Kim, P. S. 2022
A major challenge in vaccine development, especially against rapidly evolving viruses, is the ability to focus the immune response toward evolutionarily conserved antigenic regions to confer broad protection. For example, while many broadly neutralizing antibodies against influenza have been found to target the highly conserved stem region of hemagglutinin (HA-stem), the immune response to seasonal influenza vaccines is predominantly directed to the immunodominant but variable head region (HA-head), leading to narrow-spectrum efficacy. Here, we first introduce an approach to controlling antigen orientation based on the site-specific insertion of short stretches of aspartate residues (oligoD) that facilitates antigen-binding to alum adjuvants. We demonstrate the generalizability of this approach to antigens from the Ebola virus, SARS-CoV-2, and influenza and observe enhanced antibody responses following immunization in all cases. Next, we use this approach to reorient HA in an "upside down" configuration, which we envision increases HA-stem exposure, therefore also improving its immunogenicity compared to HA-head. When applied to HA of H2N2 A/Japan/305/1957, the reoriented H2 HA (reoH2HA) on alum induced a stem-directed antibody response that cross-reacted with both group 1 and 2 influenza A HAs. Our results demonstrate the possibility and benefits of antigen reorientation via oligoD insertion, which represents a generalizable immunofocusing approach readily applicable for designing epitope-focused vaccine candidates.GRAPHICAL ABSTRACT: Seasonal influenza vaccines induce a biased antibody response against the variable head of hemagglutinin, whereas conserved epitopes on the stem are a target for universal vaccines. Here we show that reorienting HA in an "upside-down" configuration sterically occludes the head and redirects the antibody response to the more exposed stem, thereby inducing broad cross-reactivity against hemagglutinins from diverse influenza strains.
View details for DOI 10.1101/2022.12.20.521291
Multimerization of Ebola GPDeltamucin on protein nanoparticle vaccines has minimal effect on elicitation of neutralizing antibodies. Frontiers in immunology Powell, A. E., Xu, D., Roth, G. A., Zhang, K., Chiu, W., Appel, E. A., Kim, P. S. 2022; 13: 942897
Ebola virus (EBOV), a member of the Filoviridae family of viruses and a causative agent of Ebola Virus Disease (EVD), is a highly pathogenic virus that has caused over twenty outbreaks in Central and West Africa since its formal discovery in 1976. The only FDA-licensed vaccine against Ebola virus, rVSV-ZEBOV-GP (Ervebo), is efficacious against infection following just one dose. However, since this vaccine contains a replicating virus, it requires ultra-low temperature storage which imparts considerable logistical challenges for distribution and access. Additional vaccine candidates could provide expanded protection to mitigate current and future outbreaks. Here, we designed and characterized two multimeric protein nanoparticle subunit vaccines displaying 8 or 20 copies of GPDeltamucin, a truncated form of the EBOV surface protein GP. Single-dose immunization of mice with GPDeltamucin nanoparticles revealed that neutralizing antibody levels were roughly equivalent to those observed in mice immunized with non-multimerized GPDeltamucin trimers. These results suggest that some protein subunit antigens do not elicit enhanced antibody responses when displayed on multivalent scaffolds and can inform next-generation design of stable Ebola virus vaccine candidates.
View details for DOI 10.3389/fimmu.2022.942897
Enzyme Therapeutic for Ischemia and Reperfusion Injury in Organ Transplantation ADVANCED MATERIALS Yan, R., Ren, J., Wen, J., Cao, Z., Wu, D., Qin, M., Xu, D., Castillo, R., Li, F., Wang, F., Gan, Z., Liu, C., Wei, P., Lu, Y. 2022; 34 (1): e2105670
Ischemia-reperfusion injury (IRI) remains as a critical challenge for organ transplantation. Herein, an enzyme therapeutic based on superoxide dismutase and catalase for effective mitigation of IRI and pathogen-induced liver injury is reported, providing a therapeutic for organ transplantation and other diseases.
View details for DOI 10.1002/adma.202105670
Systemic delivery of microRNA for treatment of brain ischemia NANO RESEARCH Liu, C., Wen, J., Li, D., Qi, H., Nih, L., Zhu, J., Xu, D., Ren, Y., Zhang, S., Han, D., Jia, H., Zhou, J., Qin, M., Wu, J., Yuan, X., Liu, J., Zhao, J., Kang, C., Lu, Y. 2021; 14 (9): 3319-3328
Dual redox mediators accelerate the electrochemical kinetics of lithium-sulfur batteries NATURE COMMUNICATIONS Liu, F., Sun, G., Wu, H., Chen, G., Xu, D., Mo, R., Shen, L., Li, X., Ma, S., Tao, R., Li, X., Tan, X., Xu, B., Wang, G., Dunn, B. S., Sautet, P., Lu, Y. 2020; 11 (1): 5215
The sluggish electrochemical kinetics of sulfur species has impeded the wide adoption of lithium-sulfur battery, which is one of the most promising candidates for next-generation energy storage system. Here, we present the electronic and geometric structures of all possible sulfur species and construct an electronic energy diagram to unveil their reaction pathways in batteries, as well as the molecular origin of their sluggish kinetics. By decoupling the contradictory requirements of accelerating charging and discharging processes, we select two pseudocapacitive oxides as electron-ion source and drain to enable the efficient transport of electron/Li+ to and from sulfur intermediates respectively. After incorporating dual oxides, the electrochemical kinetics of sulfur cathode is significantly accelerated. This strategy, which couples a fast-electrochemical reaction with a spontaneous chemical reaction to bypass a slow-electrochemical reaction pathway, offers a solution to accelerate an electrochemical reaction, providing new perspectives for the development of high-energy battery systems.
Enhanced Delivery of Rituximab Into Brain and Lymph Nodes Using Timed-Release Nanocapsules in Non-Human Primates FRONTIERS IN IMMUNOLOGY Qin, M., Wang, L., Wu, D., Williams, C. K., Xu, D., Kranz, E., Guo, Q., Guan, J., Vinters, H. V., Lee, Y., Xie, Y., Luo, Y., Sun, G., Sun, X., He, Z., Lu, Y., Kamata, M., Wen, J., Chen, I. Y. 2020; 10: 3132
Tumor metastasis into the central nervous system (CNS) and lymph nodes (LNs) is a major obstacle for effective therapies. Therapeutic monoclonal antibodies (mAb) have revolutionized tumor treatment; however, their efficacy for treating metastatic tumors-particularly, CNS and LN metastases-is poor due to inefficient penetration into the CNS and LNs following intravenous injection. We recently reported an effective delivery of mAb to the CNS by encapsulating the anti-CD20 mAb rituximab (RTX) within a thin shell of polymer that contains the analogs of choline and acetylcholine receptors. This encapsulated RTX, denoted as n-RTX, eliminated lymphoma cells systemically in a xenografted humanized mouse model using an immunodeficient mouse as a recipient of human hematopoietic stem/progenitor cells and fetal thymus more effectively than native RTX; importantly, n-RTX showed notable anti-tumor effect on CNS metastases which is unable to show by native RTX. As an important step toward future clinical translation of this technology, we further analyzed the properties of n-RTX in immunocompetent animals, rats, and non-human primates (NHPs). Our results show that a single intravenous injection of n-RTX resulted in 10-fold greater levels in the CNS and 2-3-fold greater levels in the LNs of RTX, respectively, than the injection of native RTX in both rats and NHPs. In addition, we demonstrate the enhanced delivery and efficient B-cell depletion in lymphoid organs of NHPs with n-RTX. Moreover, detailed hematological analysis and liver enzyme activity tests indicate n-RTX treatment is safe in NHPs. As this nanocapsule platform can be universally applied to other therapeutic mAbs, it holds great promise for extending mAb therapy to poorly accessible body compartments.
View details for DOI 10.3389/fimmu.2019.03132
Sustained delivery and molecular targeting of a therapeutic monoclonal antibody to metastases in the central nervous system of mice NATURE BIOMEDICAL ENGINEERING Wen, J., Wu, D., Qin, M., Liu, C., Wang, L., Xu, D., Vinters, H. V., Liu, Y., Kranz, E., Guan, X., Sun, G., Sun, X., Lee, Y., Martinez-Maza, O., Widney, D., Lu, Y., Chen, I. Y., Kamata, M. 2019; 3 (9): 706–16
Approximately 15-40% of all cancers develop metastases in the central nervous system (CNS), yet few therapeutic options exist to treat them. Cancer therapies based on monoclonal antibodies are widely successful, yet have limited efficacy against CNS metastases, owing to the low levels of the drug reaching the tumour site. Here, we show that the encapsulation of rituximab within a crosslinked zwitterionic polymer layer leads to the sustained release of rituximab as the crosslinkers are gradually hydrolysed, enhancing the CNS levels of the antibody by approximately tenfold with respect to the administration of naked rituximab. When the nanocapsules were functionalized with CXCL13-the ligand for the chemokine receptor CXCR5, which is frequently found on B-cell lymphoma-a single dose led to improved control of CXCR5-expressing metastases in a murine xenograft model of non-Hodgkin lymphoma, and eliminated lymphoma in a xenografted humanized bone marrow-liver-thymus mouse model. Encapsulation and molecular targeting of therapeutic antibodies could become an option for the treatment of cancers with CNS metastases.
Real-Time Quantification of Cell Internalization Kinetics by Functionalized Bioluminescent Nanoprobes. Advanced materials (Deerfield Beach, Fla.) Wu, D., Yang, Y., Xu, P., Xu, D., Liu, Y., Castillo, R., Yan, R., Ren, J., Zhou, G., Liu, C., Qin, M., Du, J., Hou, L., Chen, I., Kang, C., Jin, L., Wen, J., Chen, W., Lu, Y. 2019: e1902469
Cells transport mass dynamically, crossing cell membranes to maintain metabolism and systemic homeostasis, through which biomolecules are also delivered to cells for gene editing, cell reprograming, therapy, and other purposes. Quantifying the translocation kinetics is fundamentally and clinically essential, but remains limited by fluorescence-based technologies, which are semi-quantitative and only provide kinetics information at cellular level or in discrete time. Herein, a real-time method of quantifying cell internalization kinetics is reported using functionalized firefly-luciferase nanocapsules as the probe. This quantitative assay will facilitate the rational design of delivery vectors and enable high-throughput screening of peptides and other functional molecules, constituting an effective tool for broad applications, including drug development and cancer therapy.
Efficient Delivery of Nerve Growth Factors to the Central Nervous System for Neural Regeneration. Advanced materials (Deerfield Beach, Fla.) Xu, D. n., Wu, D. n., Qin, M. n., Nih, L. R., Liu, C. n., Cao, Z. n., Ren, J. n., Chen, X. n., He, Z. n., Yu, W. n., Guan, J. n., Duan, S. n., Liu, F. n., Liu, X. n., Li, J. n., Harley, D. n., Xu, B. n., Hou, L. n., Chen, I. S., Wen, J. n., Chen, W. n., Pourtaheri, S. n., Lu, Y. n. 2019: e1900727
The central nervous system (CNS) plays a central role in the control of sensory and motor functions, and the disruption of its barriers can result in severe and debilitating neurological disorders. Neurotrophins are promising therapeutic agents for neural regeneration in the damaged CNS. However, their penetration across the blood-brain barrier remains a formidable challenge, representing a bottleneck for brain and spinal cord therapy. Herein, a nanocapsule-based delivery system is reported that enables intravenously injected nerve growth factor (NGF) to enter the CNS in healthy mice and nonhuman primates. Under pathological conditions, the delivery of NGF enables neural regeneration, tissue remodeling, and functional recovery in mice with spinal cord injury. This technology can be utilized to deliver other neurotrophins and growth factors to the CNS, opening a new avenue for tissue engineering and the treatment of CNS disorders and neurodegenerative diseases.
A Bioinspired Platform for Effective Delivery of Protein Therapeutics to the Central Nervous System. Advanced materials (Deerfield Beach, Fla.) Wu, D. n., Qin, M. n., Xu, D. n., Wang, L. n., Liu, C. n., Ren, J. n., Zhou, G. n., Chen, C. n., Yang, F. n., Li, Y. n., Zhao, Y. n., Huang, R. n., Pourtaheri, S. n., Kang, C. n., Kamata, M. n., Chen, I. S., He, Z. n., Wen, J. n., Chen, W. n., Lu, Y. n. 2019: e1807557
Central nervous system (CNS) diseases are the leading cause of morbidity and mortality; their treatment, however, remains constrained by the blood-brain barrier (BBB) that impedes the access of most therapeutics to the brain. A CNS delivery platform for protein therapeutics, which is achieved by encapsulating the proteins within nanocapsules that contain choline and acetylcholine analogues, is reported herein. Mediated by nicotinic acetylcholine receptors and choline transporters, such nanocapsules can effectively penetrate the BBB and deliver the therapeutics to the CNS, as demonstrated in mice and non-human primates. This universal platform, in general, enables the delivery of any protein therapeutics of interest to the brain, opening a new avenue for the treatment of CNS diseases.
Systemic Delivery of Monoclonal Antibodies to the Central Nervous System for Brain Tumor Therapy. Advanced materials (Deerfield Beach, Fla.) Han, L. n., Liu, C. n., Qi, H. n., Zhou, J. n., Wen, J. n., Wu, D. n., Xu, D. n., Qin, M. n., Ren, J. n., Wang, Q. n., Long, L. n., Liu, Y. n., Chen, I. n., Yuan, X. n., Lu, Y. n., Kang, C. n. 2019: e1805697
As an essential component of immunotherapy, monoclonal antibodies (mAbs) have emerged as a class of powerful therapeutics for treatment of a broad range of diseases. For central nervous system (CNS) diseases, however, the efficacy remains limited due to their inability to enter the CNS. A platform technology is reported here that enables effective delivery of mAbs to the CNS for brain tumor therapy. This is achieved by encapsulating the mAbs within nanocapsules that contain choline and acetylcholine analogues; such analogues facilitate the penetration of the nanocapsules through the brain-blood barrier and the delivery of mAbs to tumor sites. This platform technology uncages the therapeutic power of mAbs for various CNS diseases that remain poorly treated.
Nanocapsules of oxalate oxidase for hyperoxaluria treatment NANO RESEARCH Zhao, M., Xu, D., Wu, D., Whittaker, J. W., Terkeltaub, R., Lu, Y. 2018; 11 (5): 2682–88
Fabrication of Hybrid Silicate Coatings by a Simple Vapor Deposition Method for Lithium Metal Anodes ADVANCED ENERGY MATERIALS Liu, F., Xiao, Q., Wu, H., Shen, L., Xu, D., Cai, M., Lu, Y. 2018; 8 (6)
View details for DOI 10.1002/aenm.201701744
A Hepatocyte-Mimicking Antidote for Alcohol Intoxication. Advanced materials (Deerfield Beach, Fla.) Xu, D. n., Han, H. n., He, Y. n., Lee, H. n., Wu, D. n., Liu, F. n., Liu, X. n., Liu, Y. n., Lu, Y. n., Ji, C. n. 2018; 30 (22): e1707443
Alcohol intoxication causes serious diseases, whereas current treatments are mostly supportive and unable to remove alcohol efficiently. Upon alcohol consumption, alcohol is sequentially oxidized to acetaldehyde and acetate by the endogenous alcohol dehydrogenase and aldehyde dehydrogenase, respectively. Inspired by the metabolism of alcohol, a hepatocyte-mimicking antidote for alcohol intoxication through the codelivery of the nanocapsules of alcohol oxidase (AOx), catalase (CAT), and aldehyde dehydrogenase (ALDH) to the liver, where AOx and CAT catalyze the oxidation of alcohol to acetaldehyde, while ALDH catalyzes the oxidation of acetaldehyde to acetate. Administered to alcohol-intoxicated mice, the antidote rapidly accumulates in the liver and enables a significant reduction of the blood alcohol concentration. Moreover, blood acetaldehyde concentration is maintained at an extremely low level, significantly contributing to liver protection. Such an antidote, which can eliminate alcohol and acetaldehyde simultaneously, holds great promise for the treatment of alcohol intoxication and poisoning and can provide therapeutic benefits.
Nanocapsules of therapeutic proteins with enhanced stability and long blood circulation for hyperuricemia management. Journal of controlled release : official journal of the Controlled Release Society Zhang, X. n., Xu, D. n., Jin, X. n., Liu, G. n., Liang, S. n., Wang, H. n., Chen, W. n., Zhu, X. n., Lu, Y. n. 2017; 255: 54–61
Among a broad spectrum of medical treatments, protein therapeutics holds tremendous opportunities for the treatment of metabolic disorders, cancer, autoimmune diseases and etc. Broad adaption of protein therapeutics, however, still remain challenging, not only because of poor protein stability, but they also experience fast clearance after administrated and elicit immune responses, resulting in undesirable biodistribution and short blood residence time. In this study, we demonstrate a novel protein delivery method via encapsulating therapeutic proteins within thin shells of poly(N-vinylpyrrolidone) (PVP), which leads to significantly improved protein stability, reduced macrophage uptake, prolonged circulation time and reduced immunogenicity. Exemplified with urate oxidase (UOx), the enzyme used for hyperuricemia treatment, as-formed UOx nanocapsules, n(UOx), exhibits enhanced stability, more significant therapeutic effects, and a more than 10-fold improvement in circulation time when compared with native UOx. This technology not only demonstrates the use of UOx nanocapsules for hyperuricemia management, but also provides a general approach for a broad spectrum of therapeutic proteins for in vivo applications.
Prolonging the plasma circulation of proteins by nano-encapsulation with phosphorylcholine-based polymer NANO RESEARCH Zhang, L., Liu, Y., Liu, G., Xu, D., Liang, S., Zhu, X., Lu, Y., Wang, H. 2016; 9 (8): 2424–32
An intracellular protein delivery platform based on glutathione-responsive protein nanocapsules. Chemical communications (Cambridge, England) Li, J. n., Zhang, L. n., Liu, Y. n., Wen, J. n., Wu, D. n., Xu, D. n., Segura, T. n., Jin, J. n., Lu, Y. n., Wang, H. n. 2016; 52 (93): 13608–11
An efficient strategy for the intracellular delivery of proteins was developed based on assembling proteins with a self-crosslinkable polymer. Such a disulfide-crosslinking structure enhances the stability of the protein-polymer assembly, and also allows effective dissociation of the assembly in response to glutathione, which allows effective delivery of various proteins with high intracellular bioactivity.
Structural insight into the type-II mitochondrial NADH dehydrogenases NATURE Feng, Y., Li, W., Li, J., Wang, J., Ge, J., Xu, D., Liu, Y., Wu, K., Zeng, Q., Wu, J., Tian, C., Zhou, B., Yang, M. 2012; 491 (7424): 478-+
The single-component type-II NADH dehydrogenases (NDH-2s) serve as alternatives to the multisubunit respiratory complex I (type-I NADH dehydrogenase (NDH-1), also called NADH:ubiquinone oxidoreductase; EC 1.6.5.3) in catalysing electron transfer from NADH to ubiquinone in the mitochondrial respiratory chain. The yeast NDH-2 (Ndi1) oxidizes NADH on the matrix side and reduces ubiquinone to maintain mitochondrial NADH/NAD(+) homeostasis. Ndi1 is a potential therapeutic agent for human diseases caused by complex I defects, particularly Parkinson's disease, because its expression restores the mitochondrial activity in animals with complex I deficiency. NDH-2s in pathogenic microorganisms are viable targets for new antibiotics. Here we solve the crystal structures of Ndi1 in its substrate-free, NADH-, ubiquinone- and NADH-ubiquinone-bound states, to help understand the catalytic mechanism of NDH-2s. We find that Ndi1 homodimerization through its carboxy-terminal domain is critical for its catalytic activity and membrane targeting. The structures reveal two ubiquinone-binding sites (UQ(I) and UQ(II)) in Ndi1. NADH and UQ(I) can bind to Ndi1 simultaneously to form a substrate-protein complex. We propose that UQ(I) interacts with FAD to act as an intermediate for electron transfer, and that NADH transfers electrons through this FAD-UQ(I) complex to UQ(II). Together our data reveal the regulatory and catalytic mechanisms of Ndi1 and may facilitate the development or targeting of NDH-2s for potential therapeutic applications.
View details for DOI 10.1038/nature11541


Cutting the Game - Grab Your Copy!
Cutting the Game by Tom Mee, Jr., a look at what it takes to bring professional baseball from the field to your television, AVAILABLE NOW!!
Step into the fascinating, usually off-limits world of the TV sports truck for a guided tour of how major television sports productions are created.
Only a limited number of copies of Cutting the Game by Tom Mee, Jr., are available. Grab yours right now!


text:
Sainte-Marthe est une commune du Sud-Ouest de la France, située dans le département de Lot-et-Garonne, en région Nouvelle-Aquitaine.

Géographie

Localisation
La commune est située dans l'aire d'attraction de Marmande.

Communes limitrophes

Climat
Le climat qui caractérise la commune est qualifié, en 2010, de « climat océanique altéré », selon la typologie des climats de la France qui compte alors huit grands types de climats en métropole. En 2020, la commune ressort du même type de climat dans la classification établie par Météo-France, qui ne compte désormais, en première approche, que cinq grands types de climats en métropole. Il s'agit d'une zone de transition entre le climat océanique et les climats de montagne et le climat semi-continental. Les écarts de température entre hiver et été augmentent avec l'éloignement de la mer. La pluviométrie est plus faible qu'en bord de mer, sauf aux abords des reliefs.

Les paramètres climatiques qui ont permis d'établir la typologie de 2010 comportent six variables pour les températures et huit pour les précipitations, dont les valeurs correspondent à la normale 1971-2000. Les sept principales variables caractérisant la commune sont présentées dans l'encadré ci-après.

Avec le changement climatique, ces variables ont évolué. Une étude réalisée en 2014 par la Direction générale de l'Énergie et du Climat complétée par des études régionales prévoit en effet que la  température moyenne devrait croître et la pluviométrie moyenne baisser, avec toutefois de fortes variations régionales. Ces changements peuvent être constatés sur la station météorologique de Météo-France la plus proche, « Fauillet », sur la commune de Fauillet, mise en service en 1992 et qui se trouve à  à vol d'oiseau, où la température moyenne annuelle est de  et la hauteur de précipitations de  pour la période 1981-2010.
Sur la station météorologique historique la plus proche, « Agen-La Garenne », sur la commune d'Estillac, mise en service en 1941 et à , la température moyenne annuelle évolue de  pour la période 1971-2000, à  pour 1981-2010, puis à  pour 1991-2020.

Urbanisme

Typologie
Sainte-Marthe est une commune rurale, car elle fait partie des communes peu ou très peu denses, au sens de la grille communale de densité de l'Insee.

Par ailleurs la commune fait partie de l'aire d'attraction de Marmande, dont elle est une commune de la couronne. Cette aire, qui regroupe , est catégorisée dans les aires de  à moins de .

Occupation des sols

L'occupation des sols de la commune, telle qu'elle ressort de la base de données européenne d'occupation biophysique des sols Corine Land Cover (CLC), est marquée par l'importance des territoires agricoles (64,2 % en 2018), néanmoins en diminution par rapport à 1990 (66,8 %). La répartition détaillée en 2018 est la suivante :
terres arables (36,6 %), forêts (26,1 %), prairies (15 %), zones agricoles hétérogènes (12,6 %), milieux à végétation arbustive et/ou herbacée (6,8 %), zones urbanisées (2,4 %), zones industrielles ou commerciales et réseaux de communication (0,4 %).

L'IGN met par ailleurs à disposition un outil en ligne permettant de comparer l'évolution dans le temps de l'occupation des sols de la commune (ou de territoires à des échelles différentes). Plusieurs époques sont accessibles sous forme de cartes ou photos aériennes : la carte de Cassini (), la carte d'état-major (1820-1866) et la période actuelle (1950 à aujourd'hui).

Risques majeurs
Le territoire de la commune de Sainte-Marthe est vulnérable à différents aléas naturels : météorologiques (tempête, orage, neige, grand froid, canicule ou sécheresse), inondations, mouvements de terrains et séisme (sismicité très faible). Il est également exposé à un risque technologique, le transport de matières dangereuses. Un site publié par le BRGM permet d'évaluer simplement et rapidement les risques d'un bien localisé soit par son adresse soit par le numéro de sa parcelle.

Risques naturels
Certaines parties du territoire communal sont susceptibles d'être affectées par le risque d'inondation par une crue à  débordement lent de cours d'eau, notamment l'Avance et le Gauret. La commune a été reconnue en état de catastrophe naturelle au titre des dommages causés par les inondations et coulées de boue survenues en 1982, 1983, 1992, 1999 et 2009.

Les mouvements de terrains susceptibles de se produire sur la commune sont des tassements différentiels.

Le retrait-gonflement des sols argileux est susceptible d'engendrer des dommages importants aux bâtiments en cas d'alternance de périodes de sécheresse et de pluie. La totalité de la commune est en aléa moyen ou fort (91,8 % au niveau départemental et 48,5 % au niveau national). Depuis le , en application de la loi ELAN, différentes contraintes s'imposent aux vendeurs, maîtres d'ouvrages ou constructeurs de biens situés dans une zone classée en aléa moyen ou fort.

Concernant les mouvements de terrains, la commune a été reconnue en état de catastrophe naturelle au titre des dommages causés par la sécheresse en 2003 et 2005 et par des mouvements de terrain en 1999.

Toponymie
La commune doit son nom à celui de la sainte patronne du village, sainte Marthe de Béthanie. La paroisse est citée pour la première fois au  par un cartulaire d'Agen faisant état de l'existence d'un village appelé Sancta Marsa.

Histoire
La commune de Sainte-Marthe est détachée de celle de Fourques-sur-Garonne le .

Politique et administration

|-
|colspan="5" align="center" bgcolor="#f3fff3" |

Démographie
Les habitants sont appelés les Saint-Marthais.

Culture locale et patrimoine

Lieux et monuments
 Église Sainte-Marthe, construite au , remaniée au  ;
 Église Saint-Sauveur, construite au , située dans le nord du territoire communal  ;
 Château de Lanauze, construit de 1751 à 1754, propriété privée, inscrit à l'inventaire supplémentaire des monuments historiques, par arrêté du , pour son élévation et sa toiture. Propriété des Séré de Lanauze au début du .

Personnalités liées à la commune

Héraldique

Voir aussi

Articles connexes
 Liste des communes de Lot-et-Garonne

Liens externes
 Site de la mairie
 Sainte-Marthe sur le site de l'Insee

Notes et références

Notes et cartes
 Notes

 Cartes

Références

Sainte-Marthe
Aire urbaine de Marmande
Sainte-Marthe (Lot-et-Garonne)
Aire d'attraction de Marmande


text:
Ej att förväxla med tjänstekort, som tjänstemän på myndigheter (till exempel poliser) använder för att identifiera sig.

Yrkeslegitimation innebär att det finns ett lagrum som beskriver vilka krav som ska vara uppfyllda för att en sådan legitimation ska kunna utfärdas, av en behörig myndighet. Vanligtvis är det ett formellt intyg, ett dokument, som certifierar att man är behörig att utöva ett yrke. Myndigheter som utfärdar yrkeslegitimationer är Socialstyrelsen för hälso- och sjukvårdsyrken, Jordbruksverket för veterinärer och djursjukskötare och Skolverket för lärare. Beteckningen legitimerad får endast användas av den som genomfört den utbildning som krävs och i vissa fall fullgjort praktisk tjänstgöring enligt särskilda föreskrifter (se tabell), samt sökt och av berörd myndighet fått legitimation att utöva ett visst yrke, samt inte fått denna legitimation indragen.

Etymologi
Legitim från mitten 1400-talet, lagenligt född/avlad, från mellanfranska legitimer och direkt från medeltida latinska legitimatus av legitimare göra laglig, förklarar sig vara laglig, från latin legitimus laglig ursprungligen fastställt i lag, i linje med lagstiftningen, från lex (genitiv legis) law  (se laglig). Överfört med innebörden äkta, genuin, verklig, dokumenterat från 1550-talet. Relaterat ord laglig.

I Sverige
Legitimationen är ett uttryck för att en yrkesutövare står under samhällets tillsyn och har godkänts för yrkesverksamhet inom det område legitimationen avser. De som har en legitimation utfärdad av Socialstyrelsen står alltid under legitimationens krav, vilket innebär att personen inte kan ha ett vårdliknande yrke som inte baseras på vetenskap, t.ex. homeopatiska yrken, och måste föra journal om de utför vårdliknande uppgifter, t.ex. bedriver massageverksamhet.

I mars 2011 godkände riksdagen en lag om lärarlegitimation. Lagen innebär krav på legitimation för tillsvidareanställning av lärare. Vissa lärargrupper är undantagna från legitimationskravet och andra omfattas inte. Lagen skulle träda i kraft den 1 juli 2012, med särskilda övergångsregler att gälla fram till 2015. Skolverket kunde inte utfärda legitimationer i den takt man räknat med, och i april 2012 godkände regeringen en hemställan om att senarelägga det fastställda datumet, och kommer därför att föreslå riksdagen att krav på lärarlegitimation senareläggs till den 1 december 2013.

Bestämmelser om legitimationen finns i:
Patientsäkerhetslag (SFS 2010:659), vilken även reglerar ensamrätt till yrke, skyddad yrkestitel och skyddad specialistbeteckning för ett antal vårdyrken;
Lag om behörighet att utöva veterinäryrket m.m. (SFS 1965:61).
Lag om verksamhet inom djurens hälso- och sjukvård (SFS 2009:302).
Förordning (2011:326) om behörighet och legitimation för lärare och förskollärare och utnämning till lektor.

Utomlands
I internationella sammanhang används samlingsbeteckningen "licensed practitioner of medicine" för läkare. En legitimerad sjuksköterska kallas "registered nurse".

Se även
Skyddad yrkestitel
Auktoriserad yrkesman
Ensamrätt till yrke
Legitimation
Reglerade yrken

Referenser

Arbetsrätt
Personcertifiering
Patientsäkerhet


text:
About Karat
Governance and Staff
Case studies, infosheets
Archival publications
KARAT » Karat in the feminist dialogue on women migrants in Europe
14-15th of October 2017 we were in Vienna at a meeting of partner organizations in the project "The Europe we want? Feminist approaches to gender, migration and democracy "(Erasmus +). The participants from Austria, Spain, Belgium, Sweden and Poland (Karat Coalition) shared their experiences in working with organizations and networks of women migrants. We also discussed the discrimination and problems encountered by women refugees or migrants in European countries. WIDE Austria and Network Of Eritrean Women organized a public debate on gender, migration and security.
You will find more about this initiative on the project page https://www.karat.org/programmes/womens-human-rights/europe-want-feminist-approaches-gender-migration-democracy/
Share the post "Karat in the feminist dialogue on women migrants in Europe"
Leaflet. Practical information for migrant women looking for a job in Poland (in russian language)
Publication "The Europe we want? Feminist approaches to gender, migration, and democracy"
The site was created with the support of the Stefan Batory Foundation under the "Democracy in Action".
Modification of the website was financed by the City of Warsawas as part of the project of the Capital Center for Support of Non-governmental Organizations.
KARAT COALITION
03-916 Warsaw, Poland
BIC (SWIFT): INGBPLPW
Bank account IBAN (EURO):
PL65 1050 1012 1000 0090 3106 2699
Bank account IBAN (PLN):
© Copyright 2022 - Karat - All rights reserved. Designed by: Condictor


text:
InfoQ Homepage News QCon Plus ML Panel Discussion: ML in Production - What's Next?
Using Reinforcement Learning To Beat Go Masters and Write Java Unit Tests (Live Webinar Feb 10th, 2022) - Save Your Seat
QCon Plus ML Panel Discussion: ML in Production - What's Next?
Nov 23, 2021 3 min read
The recent QCon Plus online conference featured a panel discussion titled "ML in Production - What's Next?" Some key takeaways were that many ML projects fail in production because of poor engineering infrastructure and a lack of intra-disciplinary communication, and that both model explainability and ML for edge computing are important technologies that are still not mature.
The panel was moderated by Frank Greco, senior technology consultant, chairman at NYJavaSIG, and QCon Plus November 2021 committee member. Panelists included Chip Huyen, a machine-learning startup founder and Lecturer at Stanford; Shijing Fang, principal data scientist at Microsoft, and Vernon Germano, senior manager of machine learning engineering at Zillow. The panelists discussed questions posed by Greco and fielded a few more from the audience at the end of the session.
Greco began by asking panelists for their opinion on why many ML projects fail in production. Germano said in his experience many organizations will focus on the data science aspect of the problem, developing models that achieve good results on test data and evaluation metrics; however, getting the models into production presents many engineering problems that require expertise the data scientists don't have. Fang added that the problem is often cultural, with a lack of a "holistic view" of the business objective and failure to communicate across departments or disciplines within the company. Huyen noted a lack of systematic postmortems for these failed projects, making it hard to know what percentage was due to problems such as a lack of tooling.
Greco then asked about continuous delivery of models, comparing the current method to the Waterfall model of software delivery. Huyen suggested that delivering models should be thought of as part of the same process as delivering the rest of the software stack, and that companies needed to focus on tools and processes. Germano noted that producing ML models did require a slightly different approach and that there was a lack of off-the-shelf infrastructure needed for the long-term "care and feeding" of models in production; instead, companies must invest in building that infrastructure. He also stressed that continuously monitoring the performance of models in production was "one of the most critical things you can do." Fang added that for reinforcement learning in particular, the problem is even more complicated due to the need for real-time collection and distribution of data.
Huyen posed a follow-up question to the panel about tooling: given that there are many commercial and open-source products dedicated to ML tooling and solving problems of deploying and monitoring models, why are companies still struggling? Fang suggested that the problem wasn't a failure of tooling. Instead, the problem is one of integrating many systems as well as dealing with complex business problems.
The panelists then answered several questions from audience members. When asked about feature engineering, Fang discussed her team's use of a "feature bank," a centralized server that documents datasets and features that can be shared across multiple projects. When asked about whether using Jupyter notebooks in production is a good practice, Germano replied that it would depend on the context. He said he had seen it work in some cases, such as overnight batch processes, but it would probably not scale to support a website with millions of users.
Another audience member asked about model interpretability and explainability. Germano suggested that with very complex deep-learning models, explainability was difficult and teams may have to trust the evaluation metrics. Huyen pointed out that explainability and interpretability have many different use cases; for example, one is to help ensure that models are unbiased and fair, but another is for helping developers to troubleshoot model performance. She noted that when a model's performance in production drifts over time, there are many possible causes, and without understanding how the model arrives at an answer it can be impossible to determine the root cause.
Greco concluded the session by asking panelists their thoughts about ML on edge devices. Huyen called this the "Holy Grail," noting that the more computation businesses could push to consumer devices, the less they would have to pay for their own computing costs. However, she said there are many problems to be solved: under-powered edge hardware, managing multiple model versions, monitoring model performance, and pushing updates. Germano agreed, and also discussed the idea of end-users running models in their web browsers, which could save businesses on compute costs and give users a better experience.
DeepMind Releases Weather Forecasting AI Deep Generative Models of Rainfall
Benefits of Loosely Coupled Deep Learning Serving


Department for Community Based Services Standards of Practice Online Manual. Chapters. 1; 2; 3; 4; 9; 10; 11; 12; 13; 19; 20; 23; 24; 25; 26; 27; 30; 31; 38 Department for Community Based Services Standards of Practice Online Manual. Chapters. 1; 2; 3; 4; 9; 10; 11; 12; 13; 19; 20; 23; 24; 25; 26; 27; 30; 31; 38 Kentucky Court of Justice The Judicial Branch of State Government for the Commonwealth of Kentucky A unified court system Legal Forms Legal Forms Legal Forms Kentucky General Stormwater Permits Have you received a letter like the one below?
If you have received a letter discussing the electronic Notice of Intent for coverage of the General Permit for Stormwater Discharges Associated with Industrial Activity (eNOIKYR00), please follow these instructions carefully.
Transportation Redesign Organizational Resources FormsLibrary View All Page Content Welcome to the forms resource page, the official source of the Kentucky Transportation Cabinet's forms. Commercial Driver's License (CDL) Verification of Document Status The CDL Verification Portal, launched by the Kentucky Transportation Cabinets Division of Driver Licensing, is designed to give commercial driver license ( CDL ) holders and their employers the ability to check the receipt and processing of their documents at any time.
To navigate through the Ribbon, use standard browser navigation keys. To skip between groups, use CtrlLEFT or CtrlRIGHT. To jump to the first Ribbon tab use Ctrl[. SCL Forms. Click on the name of a form type in the list below to access a list of links to the forms. An assessment administration manual has been part of Kentucky property tax professionals libraries for over sixty years. In January 1950, following the historic General Federation of Women's Clubs Kentucky FORMS AND MANUALS.
FORMS: Change of Officer Form and Clubwoman Ad Submission Form 2017& 2018 COF. pdf. Dues& Contributions Form 2016 Dues& Contributions. pdf. Official Score Card Form 2016 Official Score Card. pdf. MANUALS: Division of Family Support Operation Manuals. Search: Advanced Search Instructions. Manuals. Division of Family Support Operation Manual. Division of Protection and Permanency SOP's.
Kentucky Child Support Handbook. Jan 25, 2012 Association's Diagnostic and Statistical Manual of Mental Disorders and seriously limits a child's capacity to function in the home, school, or community.


The declare truly is the limit when it comes to mural painting ideas. Most people just dependence a springboard to get them thinking in the past the possibilities are appropriately vast. My make known is Michael Cooper and I have been painting murals for roughly 20 years! I know, showing off too long! But I know a event or two about it and I've seen just more or less anything you can imagine!
Here's one thig you have to know not quite murals and muralists past it comes to large-scale murals afterward a focus upon trompe l'oeil and one lessening perspective: If you can imagine it, it can more than likely be created.
Now, think big and peruse the below lists of mural painting ideas and acquire ready to tilt that hum-drum playroom, bedroom, foyer or kitchen into something that transcends space, height and time!
I have to give a positive response that the popularity of this is higher than my wildest imagination. It's agreed not child's play! This is big business! Interior designers, retailers, artists, even parents and grandparents are finding a lot of freedom of outing in creating the perfect mural for a child's room.
It's my suggestion that all goes in a child's room as it relates to color. It doesn't have to flow taking into consideration the settle of the colors in your house correspondingly just permit your imagination to direct wild. And remember, most kids view their rooms as their "fort" or "princess castle" therefore don't be too serious. This is their melody – where they get to be creative and…they get to be kids!
Here you are at our site, content above published by zabelyesayan.com. Today we are pleased to announce we have found an incredibly interesting topic to be pointed out. namely, Dr who Wall Mural. Most people trying to find specifics of Dr who Wall Mural and certainly one of them is you, is not it?
Related Posts of "Dr who Wall Mural"


text:
Q: React not updating state on Child Component load So my interface is such that I have a MainScreen Component and then a UserList and People children component...when I click on the name in the list it runs a prop function from the Mainscreen and updated a prop which is sent to the People component I run a JS and update the prop I send to the People component...Person Details box in the graphic.....

So here is my People Component::
import { useState } from 'react'
import { FontAwesomeIcon } from "@fortawesome/react-fontawesome";
import { faXmark } from '@fortawesome/free-solid-svg-icons'
import { faPlusCircle } from '@fortawesome/free-solid-svg-icons'

function People(props){
    //LINE 8
    console.log('Start People')
    console.log(props.userDet)
    console.log(props.userDet.FirstName)
    const users = props.userDet
    console.log('Users vairable')
    console.log(users.FirstName) //returns true
    console.log(props.userDet.hasOwnProperty('FirstName'))
    const [fName,setfName] = useState(users.FirstName || 'n')
    const [lName,setlName] = useState(users.LastName || 'n')
    console.log('fName')
    console.log(fName)
    console.log(props.userDet.FirstName)
    //LINE 21

    const handleChange = e => {
        console.log('handle change running')
        if(e.target.name === 'fName'){
            setfName(e.target.value)
        }
        else{
            setlName(e.target.value)
        }

      }

    function formatPhoneNumber(phoneNumberString) {
        var cleaned = ('' + phoneNumberString).replace(/\D/g, '');
        var match = cleaned.match(/^(\d{3})(\d{3})(\d{4})$/);
        if (match) {
          return '(' + match[1] + ') ' + match[2] + '-' + match[3];
        }
        return null;
    }

    var phoness = props.userDet.phones;
    //console.log('phoness');
    //console.log(phoness);
    const onephone = phoness.map((phone,index) =>

{phone.phone_type}

{formatPhoneNumber.call(this, phone.phone_number)}

<FontAwesomeIcon icon={faXmark}/>

)

    return (

Person Details

First Name:

<input onChange={handleChange} name="fName" type="text" value={fName} />

Last Name:

<input onChange={handleChange} name="lName" type="text" value={lName} />

Person Phones<FontAwesomeIcon icon={faPlusCircle}/>

        {onephone}

)

}

export default People;

The returning Javascript shows that the prop is set but I can't get it to set the STATE because it is goint into an input field and needs to be updateable....no idea what is going on or why the state is not being updated.....
The JAVASCRIPT CONSOLE show the following

A: Add useEffect after line 21 like this:
useEffect(() => {
   setfName(users.FirstName);
   setlName(users.LastName);
}, [users.FirstName, users.LastName]);


The Taylor Swift-approved shoe trend you'll love!
If you've been following my blog for a while, you'll know that when it comes to shoes, i mostly tend to gravitate towards the "borrowed from the boys" styles. Loafers, Brogues, Oxfords.... I love em! I'd pair them with almost everything. Although, I do love me some stunning, feminine heels and strappy sandals. But there's something about this shoe trend which takes your look to a whole new level of chic. Practical, unpredictable, trendy and majorly stylish; they are an amazing departure from the usual shoes people tend to sport. They instantly elevate your outfit to several notches. This trend is way more versatile than it seems. Pair it with jeans, skirts, dresses, maxis, shorts and pretty much everything. Just don't overdo it. These shoes are a statement in their own right. Let them stand out in your outfit.
If there's one celebrity who could be the official ambassador of this trend, it would undoubtedly be none other than, Taylor Swift. This girl knows exactly how to work the hell out of this trend. Trust her to make them look as feminine and chic as ever. Here's proof!
If she doesn't sell you on this trend, what will? Need I say more?
Read on to see exactly why this shoe trend has me and a horde of other bloggers, fashion people and celebs nothing short of obsessed.
Warning: major shoe lust ahead!


It's sunblock and swimsuit time in San Diego! Most of us are making sure we have our summer essentials in place, and pretty soon it will be time do your favorite summer activities! Like clockwork, my clients begin to express anxiety about an upcoming pool party or BBQ where they may be wearing a lot less than they have in the last few months. I'm getting the annual calls asking, "What's the best way to lose weight?", and more often, "I can lose the weight but gain it right back, how can you help me?".
If you've never lost a pound or if you've successfully lost weight only to gain it back, you are certainly not alone. Cutting calories, exercising more, and watching your carbs is not enough on their own. Almost everyone knows what they need to do to lose weight, but may not be clear on how to make it happen. The most powerful aspect of moving towards a healthy body is a change in mindset. Knowing that each individual has their own reasons for wanting to change, what works for one client will almost certainly not work for everyone. Creating a specific plan, tailored to your unique thought process, can make a significant difference in effective weight loss.
You can use any reasonable diet you want- when you pair it with new habits of thought you will see it work. The question is not simply 'What is the best weight loss plan?', but rather- 'How can I think differently about myself and my health?'. This is where cognitive behavioral therapy (CBT) comes into play, as it guides you to focus on changing your perceptions of yourself and replace sabotaging thoughts, which can lead to massive long-term changes in your health.
Do this first before anything else….
One of the first exercises I complete with clients is to create an 'advantages' card, which is outlined with more detail in Judith Beck's book, The Beck Diet Solution. When you write down the reasons you want to lose weight, it can really add a boost to your motivation. Looking at it a couple of times a day can build excitement in reaching your big goal. The advantages card is your 'eyes on the prize' reminder, and whenever you hear yourself saying "One donut won't hurt", you pull out your handy card out to kindly remind you what you truly want. The more you conquer your cravings, the more confident you will become in knowing you can do this!
Relapse is part and parcel of changing any habit- it's also one of the most exciting opportunities for change. Now is when your new CBT skills are put to the test, as you begin to see how to shift your behaviors and habits that combat those negative, self-sabotaging thoughts. We only change when we are uncomfortable, so when you are struggling or simply doubting yourself this is when the magic happens. Most of us are much more capable than we give ourselves credit for; imagine how pushing yourself through this challenge will confirm strong you really are. This is the time to use your supports to boost you up and let you know you can do it!
If you're reading this, it's likely that you've already discovered that establishing weight loss plans on without outside help often doesn't produce the results you aim for. Evaluating and making shifts in the way you look at your problem can create a long-lasting solution that will not only help you lose weight, but also help you recognize skills and resources within you that can be useful in any aspect of your life.


text:
Methods for evaluating natural experiments in obesity: A systematic review
Wendy Bennett, Renee Wilson, Allen Zhang, Eva Tseng, Emily Knapp, Hadi H K Kharrazi, Elizabeth Stuart, Oluwaseun Shogbesan, Eric B Bass, Lawrence J Cheskin
Background: Given the obesity pandemic, rigorous methodological approaches, including natural experiments, are needed. Purpose: To identify studies that report effects of programs, policies, or built environment changes on obesity prevention and control and to describe their methods. Data Sources: PubMed, CINAHL, PsycINFO, and EconLit (January 2000 to August 2017). Study Selection: Natural experiments and experimental studies evaluating a program, policy, or built environment change in U.S. or non-U.S. populations by using measures of obesity or obesity-related health behaviors. Data Extraction: 2 reviewers serially extracted data on study design, population characteristics, data sources and linkages, measures, and analytic methods and independently evaluated risk of bias. Data Synthesis: 294 studies (188 U.S., 106 non-U.S.) were identified, including 156 natural experiments (53%), 118 experimental studies (40%), and 20 (7%) with unclear study design. Studies used 106 (71 U.S., 35 non-U.S.) data systems; 37% of the U.S. data systems were linked to another data source. For outcomes, 112 studies reported childhood weight and 32 adult weight; 152 had physical activity and 148 had dietary measures. For analysis, natural experiments most commonly used cross-sectional comparisons of exposed and unexposed groups (n = 55 [35%]). Most natural experiments had a high risk of bias, and 63% had weak handling of withdrawals and dropouts. Limitation: Outcomes restricted to obesity measures and health behaviors; inconsistent or unclear descriptions of natural experiment designs; and imperfect methods for assessing risk of bias in natural experiments. Conclusion: Many methodologically diverse natural experiments and experimental studies were identified that reported effects of U.S. and non-U.S. programs, policies, or built environment changes on obesity prevention and control. The findings reinforce the need for methodological and analytic advances that would strengthen evaluations of obesity prevention and control initiatives.
https://doi.org/10.7326/M18-0309
Genetic Selection
Bennett, W., Wilson, R., Zhang, A., Tseng, E., Knapp, E., Kharrazi, H. H. K., ... Cheskin, L. J. (2018). Methods for evaluating natural experiments in obesity: A systematic review. Annals of Internal Medicine, 168(11), 791-800. https://doi.org/10.7326/M18-0309
Methods for evaluating natural experiments in obesity : A systematic review. / Bennett, Wendy; Wilson, Renee; Zhang, Allen; Tseng, Eva; Knapp, Emily; Kharrazi, Hadi H K; Stuart, Elizabeth; Shogbesan, Oluwaseun; Bass, Eric B; Cheskin, Lawrence J.
In: Annals of Internal Medicine, Vol. 168, No. 11, 05.06.2018, p. 791-800.
Bennett, W, Wilson, R, Zhang, A, Tseng, E, Knapp, E, Kharrazi, HHK, Stuart, E, Shogbesan, O, Bass, EB & Cheskin, LJ 2018, 'Methods for evaluating natural experiments in obesity: A systematic review', Annals of Internal Medicine, vol. 168, no. 11, pp. 791-800. https://doi.org/10.7326/M18-0309
Bennett W, Wilson R, Zhang A, Tseng E, Knapp E, Kharrazi HHK et al. Methods for evaluating natural experiments in obesity: A systematic review. Annals of Internal Medicine. 2018 Jun 5;168(11):791-800. https://doi.org/10.7326/M18-0309
Bennett, Wendy ; Wilson, Renee ; Zhang, Allen ; Tseng, Eva ; Knapp, Emily ; Kharrazi, Hadi H K ; Stuart, Elizabeth ; Shogbesan, Oluwaseun ; Bass, Eric B ; Cheskin, Lawrence J. / Methods for evaluating natural experiments in obesity : A systematic review. In: Annals of Internal Medicine. 2018 ; Vol. 168, No. 11. pp. 791-800.
@article{e2a362195b8243c1ab31e76ef8231152,
title = "Methods for evaluating natural experiments in obesity: A systematic review",
abstract = "Background: Given the obesity pandemic, rigorous methodological approaches, including natural experiments, are needed. Purpose: To identify studies that report effects of programs, policies, or built environment changes on obesity prevention and control and to describe their methods. Data Sources: PubMed, CINAHL, PsycINFO, and EconLit (January 2000 to August 2017). Study Selection: Natural experiments and experimental studies evaluating a program, policy, or built environment change in U.S. or non-U.S. populations by using measures of obesity or obesity-related health behaviors. Data Extraction: 2 reviewers serially extracted data on study design, population characteristics, data sources and linkages, measures, and analytic methods and independently evaluated risk of bias. Data Synthesis: 294 studies (188 U.S., 106 non-U.S.) were identified, including 156 natural experiments (53{\%}), 118 experimental studies (40{\%}), and 20 (7{\%}) with unclear study design. Studies used 106 (71 U.S., 35 non-U.S.) data systems; 37{\%} of the U.S. data systems were linked to another data source. For outcomes, 112 studies reported childhood weight and 32 adult weight; 152 had physical activity and 148 had dietary measures. For analysis, natural experiments most commonly used cross-sectional comparisons of exposed and unexposed groups (n = 55 [35{\%}]). Most natural experiments had a high risk of bias, and 63{\%} had weak handling of withdrawals and dropouts. Limitation: Outcomes restricted to obesity measures and health behaviors; inconsistent or unclear descriptions of natural experiment designs; and imperfect methods for assessing risk of bias in natural experiments. Conclusion: Many methodologically diverse natural experiments and experimental studies were identified that reported effects of U.S. and non-U.S. programs, policies, or built environment changes on obesity prevention and control. The findings reinforce the need for methodological and analytic advances that would strengthen evaluations of obesity prevention and control initiatives.",
author = "Wendy Bennett and Renee Wilson and Allen Zhang and Eva Tseng and Emily Knapp and Kharrazi, {Hadi H K} and Elizabeth Stuart and Oluwaseun Shogbesan and Bass, {Eric B} and Cheskin, {Lawrence J}",
doi = "10.7326/M18-0309",
journal = "Annals of Internal Medicine",
publisher = "American College of Physicians",
T1 - Methods for evaluating natural experiments in obesity
T2 - A systematic review
AU - Bennett, Wendy
AU - Wilson, Renee
AU - Zhang, Allen
AU - Tseng, Eva
AU - Knapp, Emily
AU - Kharrazi, Hadi H K
AU - Stuart, Elizabeth
AU - Shogbesan, Oluwaseun
AU - Bass, Eric B
AU - Cheskin, Lawrence J
N2 - Background: Given the obesity pandemic, rigorous methodological approaches, including natural experiments, are needed. Purpose: To identify studies that report effects of programs, policies, or built environment changes on obesity prevention and control and to describe their methods. Data Sources: PubMed, CINAHL, PsycINFO, and EconLit (January 2000 to August 2017). Study Selection: Natural experiments and experimental studies evaluating a program, policy, or built environment change in U.S. or non-U.S. populations by using measures of obesity or obesity-related health behaviors. Data Extraction: 2 reviewers serially extracted data on study design, population characteristics, data sources and linkages, measures, and analytic methods and independently evaluated risk of bias. Data Synthesis: 294 studies (188 U.S., 106 non-U.S.) were identified, including 156 natural experiments (53%), 118 experimental studies (40%), and 20 (7%) with unclear study design. Studies used 106 (71 U.S., 35 non-U.S.) data systems; 37% of the U.S. data systems were linked to another data source. For outcomes, 112 studies reported childhood weight and 32 adult weight; 152 had physical activity and 148 had dietary measures. For analysis, natural experiments most commonly used cross-sectional comparisons of exposed and unexposed groups (n = 55 [35%]). Most natural experiments had a high risk of bias, and 63% had weak handling of withdrawals and dropouts. Limitation: Outcomes restricted to obesity measures and health behaviors; inconsistent or unclear descriptions of natural experiment designs; and imperfect methods for assessing risk of bias in natural experiments. Conclusion: Many methodologically diverse natural experiments and experimental studies were identified that reported effects of U.S. and non-U.S. programs, policies, or built environment changes on obesity prevention and control. The findings reinforce the need for methodological and analytic advances that would strengthen evaluations of obesity prevention and control initiatives.
AB - Background: Given the obesity pandemic, rigorous methodological approaches, including natural experiments, are needed. Purpose: To identify studies that report effects of programs, policies, or built environment changes on obesity prevention and control and to describe their methods. Data Sources: PubMed, CINAHL, PsycINFO, and EconLit (January 2000 to August 2017). Study Selection: Natural experiments and experimental studies evaluating a program, policy, or built environment change in U.S. or non-U.S. populations by using measures of obesity or obesity-related health behaviors. Data Extraction: 2 reviewers serially extracted data on study design, population characteristics, data sources and linkages, measures, and analytic methods and independently evaluated risk of bias. Data Synthesis: 294 studies (188 U.S., 106 non-U.S.) were identified, including 156 natural experiments (53%), 118 experimental studies (40%), and 20 (7%) with unclear study design. Studies used 106 (71 U.S., 35 non-U.S.) data systems; 37% of the U.S. data systems were linked to another data source. For outcomes, 112 studies reported childhood weight and 32 adult weight; 152 had physical activity and 148 had dietary measures. For analysis, natural experiments most commonly used cross-sectional comparisons of exposed and unexposed groups (n = 55 [35%]). Most natural experiments had a high risk of bias, and 63% had weak handling of withdrawals and dropouts. Limitation: Outcomes restricted to obesity measures and health behaviors; inconsistent or unclear descriptions of natural experiment designs; and imperfect methods for assessing risk of bias in natural experiments. Conclusion: Many methodologically diverse natural experiments and experimental studies were identified that reported effects of U.S. and non-U.S. programs, policies, or built environment changes on obesity prevention and control. The findings reinforce the need for methodological and analytic advances that would strengthen evaluations of obesity prevention and control initiatives.
U2 - 10.7326/M18-0309
DO - 10.7326/M18-0309
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
10.7326/M18-0309


text:
By Stephan Uersfeld
Bayer Leverkusen's Leon Bailey will look to leave club if playing time doesn't improve - source
Leon Bailey will be considering his options in January if his situation at Bayer Leverkusen does not improve, a source close to the player has told ESPN FC.
Bailey, 21, one of the breakout stars of the 2017-2018 Bundesliga season, has seen his playing time limited at Bayer Leverkusen this term. While featuring in all but one competitive match, the Jamaica youth international winger has not started in a league game since Sept. 26.
Transfer grades: Rating every major signing from Europe
Why did Prem teams spend less this window?
European transfer review: Successes and failures
Bailey came off the bench during the second half in the four matches which followed and has only spent 514 minutes of a possible 810 on the pitch so far. After 12 goals and 6 assists across all competitions last term he currently stands at just one goal on the second match day this season.
And citing Bailey's record last season, a source close to the player told ESPN FC that in January it will "be considered whatever is in the best interest of the player and in this case it may not be to remain at Leverkusen under these circumstances."
"Leon is 21 now, with aspirations of being one of the worlds top players. He can't do so from the bench in Leverkusen," the source added, explaining that in January all options will be considered if his situation at Bayer does not change.
In August, Bailey signed a new five-year deal at Leverkusen. But the source said he was confident both parties could find a "mutually beneficial" solution "as to avoid leaving or staying with hard feelings."
In the summer, Bailey told kicker that there was concrete interest in him amid rumoured links with Roma, Chelsea and Liverpool.
Meanwhile, the president of the Jamaican Football Association has accused Bailey of having an attitude problem.
In an ongoing dispute that is yet to see the winger represent the country of his birth, Bailey was called up to the Jamaica squad in October but failed to make his competitive debut after his brother didn't receive a call-up.
When asked by ESPN FC if he thought Bailey had a slight attitude problem, president Michael Ricketts said: "Yes, I do think so, I really do. He's been very indecisive. He won't become eligible for another country for many years and by then he would be in his late 20s which means he would have wasted a number of years.
"I think he needs to relax a little, stay focused and just let things unfold. He's a good player, a high-quality player, but he must stay focused and humble."


Turn to this resource all year long for engaging reading response activities that deepen comprehension and increase motivation! Includes graphic organizers, collaborative bulletin boards, dramatic activities, and hands-on projects for responding to fiction and non-fiction. A great supplement to any independent reading program!


So a TED talk has been on your vision board for a while, or maybe the opportunity to speak presented itself and you want to take it? Either way – good for you! It is absolutely a platform you can take advantage of!
If you have a TEDx stage in your sights, then you are probably an accomplished speaker or at the very least are comfortable speaking in front of a crowd. As long as you can get your presentation nailed down, you will be fine, right?
You: I am so excited to finally make this vision come true.
Hag in the Attic: That's nice! It is probably going to be more difficult than you think.
You: I have an idea worth spreading!
Hag in the Attic: Yes! So have other people on the same topic and they most likely had better credentials than you.
You: That doesn't really matter. They approved my talk. I have been invited to speak.
Hag in the Attic: True, but that was before they knew you had trouble memorizing your speeches. They aren't going to be very happy when they find out you wing it.
You: I can memorize. The good news is I really know my topic.
Hag in the Attic: Okay great! Just make sure that you don't talk down to the audience in your speech. Nothing worse than having to listen to someone who thinks they know everything, and you definitely don't know everything.
You: I wouldn't do that. Would I? Maybe this isn't such a good idea. If only there was someone to guide me through this. I really do feel like I have something worthwhile to say.
If you have ever had the Hag in The Attic show up when she wasn't invited trying to wreak havoc on your plans, Kim Boudreau Smith knows how you feel. Kim is masterful at taming the hag for women who are trying to use their voices in bold and powerful ways. A TEDx talk doesn't get much bolder and having an ally to help tame the hag with a whole host of other services can be your secret weapon for success.
Kim Boudreau Smith understands that when the stakes are high, the best speakers have coaches to help craft and hone your message, work with flow and memorization techniques, and share a toolbox full of tips and skills that will calm nerves and quiet the hag. If you are looking to have a powerful stage presence and deliver a memorable and moving presentation, you will want to take advantage of the services Kim has to offer.
There is much at stake and you don't want to leave it to chance. Set up an opportunity to talk with Kim about what options are available for creating the best TEDx experience as possible. Please email her at Kim@kimboudreausmith.com or through the online form here.
You have been preparing for this talk your whole career. Why would you not utilize every tool possible to give your best and boldest performance? You and your audience deserve an experience that you won't forget! Contact Kim today!


Sapporo Beer dates back to 1876, with the founding of Kaitakushi Brewery, the first Bavarian-style brewery in Japan. Sapporo lagers have a crisp, refreshing taste that can be enjoyed by itself or as the perfect complement to any meal.
The original. The icon. The perfect beer to pair with any meal and any occasion. Kampai!


Keita Bates-Diop is leaving Ohio State to enter the NBA draft. He explained why during a press conference Monday also attended by his parents and Ohio State coach Chris Holtmann.
The NBA draft is tonight. Coverage begins on ESPN at 7 p.m.
1. For the second year in a row, there is a Southwest Ohio connection.
Last year, it was Luke Kennard. The Franklin High School graduate went to the Detroit Pistons in the first round.
This year it's Vincent Edwards, a former Middletown Middie who just finished up a strong four-year career at Purdue.
Two sites have projected the versatile forward as a second-round pick.
2. Dayton could have a player drafted.
Kostas Antetokounmpo didn't do much in a Flyers uniform, but his potential was obvious every time he stepped on the court.
The NBA draft is pretty much all about potential, so he might hear his name called before all is said and done.
No Dayton player has been drafted since Negele Knight in 1990, but four Flyers have made it to the league since 1999.
3. Ohio State likely will have a player drafted.
After playing a vital role in the Buckeyes' surprising success in year one under Chris Holtmann, Keita Bates-Diop profiles as a perfect fit in today's NBA.
An athletic player with long arms who can shoot the 3 and play defense, the reining Big Ten Player of the Year could go in the first round.
The last Ohio State player drafted was D'Angelo Russell, who went No. 2 overall to the Los Angeles Lakers in 2015. He's since been traded to the Brooklyn Nets.
"You're talking about an elite athlete on the wing position."
4. A pair of Cincinnati Bearcats are also in the running.
Forwards Jacob Evans and Gary Clark are also on the radar of NBA teams.
Sports Illustrated ranks Evans as the No. 36 prospect with Clark at 55, but Sporting News has both higher with Evans at No. 24 and Clark at 43.
CBS Sports ranks Evans 48th and Clark 82nd.
Lance Stephenson is the most-recent Bearcat to be drafted. He went to the Pacers in the second round in 2010.
5. Expect a lot of tall young collegians and one European to be taken early in the draft.
The consensus seems to be the top prospects are Deandre Ayton of Arizona, Jaren Jackson Jr. of Michigan State and Marvin Bagley III of Duke with Mo Bamba of Texas and Michael Porter Jr. are wildcards with rising stocks.
All of them spent one year in college and are listed at 6-foot-10 or taller, but they have different sorts of games.
Luka Doncic, a 6-6 guard from Slovenia, is also expected to go very early while college freshman point guards Collin Sexton (Alabama) and Trae Young (Oklahoma) are also intriguing prospects.


Detective Clarence Daly (1885-1926) is part of a collateral line but researching him was fun. A family story said there was a "Clarence Daly" who became a New York City policeman and died on the job. Oddly enough, that family story is true.
Most family stories may contain a hint of the true story or are just wishful thinking but this one turns out to be true. For years I couldn't find a Clarence Daly so I wasn't really looking for him. Then one day I decided to look at my great-grandfather's brother and his family. I realized John Robert Daly (1848-1915) lived across town from my great-grandfather, James Martin Daly (1850-1927). James was in Sayre (PA) and John was in South Waverly (PA) or Waverly village (NY). Digging into John's family I came across Clarence and decided to spend some time looking at him.
That "some time" turned into several months and lots of records because Clarence was in the newspapers a lot once he became an NYPD detective. I've been tinkering with the idea of writing short stories about specific ancestors so I chose Detective Clarence Daly as my first subject. The photo at right shows Clarence in 1916 as a member of his sister Mary's wedding to George Sutton.
The story also follows his two children, John (1916-2003) and Loretta (1918-1988), as far as I could find them so far.


text:
Crimson Tide separates itself from rest of the SEC
Randy Kennedy | rkennedy@al.com
TUSCALOOSA -- Win No. 19 in a row for Alabama did more than maintain the Crimson Tide's No. 1 ranking. It solidified Alabama as the country's best program. And it's not even close.
What Alabama did to a proud but rebuilding Florida team Saturday night in Bryant-Denny Stadium has to leave the rest of the country wondering what it might take to knock off the Crimson Tide.
Alabama and Florida entered Saturday night as the two most recent national champions and the standard bearers for college football. Both had won 30 games since 2008, more than anyone else. The two had split the last two SEC championship games.
But the gulf between the Crimson Tide and Gators today is as wide as John Brantley's eyes with a blitzing Mark Barron closing in on him.
A quick recap on where this Alabama team stands today: It has beaten nine straight ranked opponents, including a program-record six straight over top-10 teams. Bama has won 29 regular-season games in a row, also a school record. Saturday night's dominating win was over a team that had not lost in its last 24 regular-season games and had not even been an underdog in its last 40 contests.
It's easy to say the Gators were overrated as the seventh-ranked team entering the game. But what other visiting team could have come to Bryant-Denny Stadium Saturday night and done much better? How many others would even relish the shot at this point?
It's easy to romanticize the great teams of Alabama's past. And it's not worth the effort to compare the current team to ones from 1965 or 1979 or even 1992.
But it's easy to look at the recent past -- plus project what the roster is going to look like in the next couple of years -- and realize that Alabama has never been more firmly entrenched as the country's elite program.
Saturday night's blowout was the most significant game of the season, not only because it was against Florida but because of the way it was accomplished.
Heisman Trophy winner Mark Ingram, fellow running back Trent Richardson and quarterback Greg McElroy (now 19-0 as a college starter) all played well but didn't put up big numbers.
The stars of this game were almost all on defense. Theodore's C.J. Mosley looked like he was back playing against Alma Bryant the way he was flying around the field and even scored a touchdown on his first interception. Courtney Upshaw had the best game for an Alabama defender since Marcell Dareus in last year's BCS national championship game. And Dareus finally played like the disruptive force he was expected to be this season.
The conventional wisdom was that Alabama would have to be beaten before the defense got some experience and settled down. But now the Crimson Tide is 5-0, and it's hard to image its remaining opponents seeing any relief.


March Madness is here and that means it's almost time for the 2018 NCAA Tournament.
The conference tournaments will lead to one of the most highly anticipated dates in college basketball - Selection Sunday. The NCAA Tournament bracket will be revealed on Sunday, March 11, at 6 p.m. ET on TBS.
From there, the Field of 68 will be set and it will be NCAA Tournament time. Below is information on the important dates and locations for all of March Madness.
When is March Madness 2018?
After Selection Sunday, the First Four games will kick off March Madness in Dayton, Ohio, on Tuesday, March 13, and Wednesday, March 14. The real first round begins after that on March 15 and 16, with the second round following on March 17 and 18.
The following week's games start with the Sweet 16 on March 22 and March 23 and end with the Elite Eight on March 24 and March 25.
The Final Four games will take place in San Antonio on Saturday, March 31. The national championship game caps March Madness on Monday, April 2.
Below is a full schedule for the 2018 NCAA Tournament with dates, times and locations from Selection Sunday to championship Monday.
Here is the TV schedule for each round of the NCAA Tournament. You can also live stream the entire NCAA Tournament with the March Madness app.
At NCAA.com you can find a blank NCAA Tournament bracket to fill out during the Selection Sunday show. Sporting News will also have a complete, printable bracket following the show. Here is Sporting News' latest NCAA Tournament bracket projection.