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Binge at Cork Midsummer
Tuesday 30 June 2020 - 10:07 to Sunday 12 July 2020 - 10:07
For more information and for tickets follow the link
BINGE was commissioned by La Jolla Playhouse in San Diego who had paused all of their activities out of respect for the anti-racism movement in the U.S. It will now be possible to participate in BINGE from Tuesday 30 June - tickets will go on sale on 12 June.
In the virtual company of an artist, transform the solitary experience of binge-watching television shows to bring you a little solace at home.
A one-on-one performance piece that takes the solitary experience of binge-watching television shows and transforms it into an opportunity to find comfort in the lives of fictional characters. Participating artists include Ruairí Ó'Donnabháin and Louise White. Tailor-made to fit the life of each individual audience member, the performance offers a live Zoom session with a personal artist companion, resulting in the prescription of a classic television episode to provide a little bit of solace at home. Leave your own drama behind, and insert yourself into a world where whatever the drama, it'll probably be solved in under 30 minutes.
Brian Lobel is a performer, teacher and curator who is interested in creating work about bodies and how they are watched, policed, poked, prodded and loved by others. His practice is most efficiently described as Former-American-Camp-Counselor-Turned-Performance-Artist, and his work has shown work internationally in a range of contexts from Sydney Opera House, to Harvard Medical School, to the National Theatre (London) and Lagos Theatre Festival, blending provocative humour with insightful reflection…
Cork Midsummer Festival


Posted on July 17, 2016 by catsynth	This entry was posted in Music, Reviews, San Francisco, Synthesizers and tagged amanda chaudhary, analog, bran...(pos), electronic, electronic music, experimental music, funk, haight, jazz, modular, moog, Music, nord, passions nouveau, review, Reviews, San Francisco, second act, Synthesizers, theremini, video. Bookmark the permalink.
Looks like you really enjoyed yourself and I'm glad the audience liked it too !


The Computer Based Examination in respect of the Delhi Police Constable Recruitment was held from 5 Dec to 8 Dec 2017 at different centres all over the country.
As of now, The Staff Selection Commission has uploaded official SSC Delhi Police Answer Key which will help candidates to recheck the answers they marked. The candidates' response sheet along with the tentative answer keys are now available on the link given below.
Representations in respect of the tentative answer keys, if any, may be submitted online till 22-11-2017 (5.30 PM) on payment of Rs. 100/- per question/answer challenged. Representations received after 5.30 PM on 22-12-2017 will not be entertained under any circumstances.


text:
va ser un lluitador rus, especialista en lluita grecoromana. Va competir sota bandera de la Unió Soviètica i va guanyar una medalla olímpica.

Va començar a lluitar amb tan sols 16 anys i ben aviat fou un dels millor lluitadors soviètics del pes wèlter. El 1956 va prendre part en els Jocs Olímpics d'Estiu de Melbourne, on va guanyar la medalla de plata en la competició del pes wèlter del programa de lluita grecoromana.

En el seu palmarès també destaca una medalla d'or al Campionat del Món de lluita de 1955 i a la Copa del Món de lluita de 1956. així com els campionats nacionals de 1954 i 1955. A la fi dels Jocs de 1956 va passar al pes mitjà i al pes lleuger, però sense obtenir cap resultat destacable.

Una vegada retirat de l'esport, el 1970, va treballar com a responsable de diverses explotacions mineres de Sibèria. Morí el gener de 1985 a causa d'un atac de cor.

Referències

Lluitadors soviètics
Persones de la província de Kémerovo
Medallistes soviètics als Jocs Olímpics d'estiu de 1956
Morts a Rússia

redpajama_set_name: RedPajamaWikipedia


This book has 2 sections: 1st section will lead you through a step-by-step process in what you need to do before, during and after an interview. The 2nd section is Discovering Your Genius: Workbook on Skills Identification and Goal Setting. This workbook will help you discover your personality profile in which you can use in writing your cover letter and resume as well as prepare you for speaking while in the interview. By knowing all this information about yourself will make you more confident in yourself and your abilities. It also has a step-by-step process formula in creating goals for yourself. Without setting goals, you may struggle to find direction!
Interview preparation: Understand yourself before going for that interview, and you will have a greater chance of getting that job you dream of.


text:
\section{Introduction}

In the context of the nonlinear light-matter interaction, spontaneous parametric-down conversion (SPDC) is the well-known nonlinear optical process in which a twin-photons beam, a pair of signal-idler photons, is generated out of quantum vacuum when a pump laser beam is incident onto an optical nonlinear material \cite{shySPDC,boyd,agrawal,entanglementReview}.
In SPDC, an input photon of classical laser pump at higher frequency is annihilated and two entangled photons are created at lower frequencies under the so-called phase-matching (PM) conditions \cite{shySPDC}, i.e., energy-momentum conservation.
SPDC sources in bulk NLCs, as an entangled-squeezed biphoton source (for more details see Ref.~\cite{shySPDC}), are very interested compared to other technologies such as superconductors since they are inexpensive, user-friendly, work at room-temperature, needs no cooling, and finally can be on-chip using integrated quantum photonic techniques in order to be commercialized.
That is why SPDC in NLCs has been variety range of applications \cite{quantummetrologybook} from the fundamental to the applied point of view such as quantum communication \cite{pirandola2015Communication}, entanglement generation and nonlocal realism tests \cite{epr,nonlocal2,nonlocal3,nonlocal4,aliBellBBO,aliBellPPKTP,nonlocalGenoveseReview2005,polarizationentanglement1995,Forbes}, quantum state teleportation \cite{teleport2001shih,teleportationReview2015}, quantum illumination \cite{qillumination2,qillumination5}, quantum imaging \cite{imagingGenoveseReview2016,mexico1,mexico2,imagingshy}, and quantum interferometry \cite{Mandel1,interferometryGenovese2021} and finally quantum efficiency and absorption measurement \cite{klyshkoEfficiency,absorb1,absorb2,absorb3}.

Some well-known physical technologies in the context of the quantum light-matter interaction, such as optical spectroscopy, magnetic resonance imaging, and tomography have been employed for understanding biological structure and disease treatment to medical diagnosis. Beyond these, recently, the SPDC-/entanglement-based methods, have attracted interests to be applied in the field of biology and medicine from different points of view such as metrology, phenomenology, philosophy and consciousness \cite{brain1,brain2,brain3,brain4,brain5,brain6,proteinconcentration,human,octbiology}.
In Refs.~\cite{brain1,brain2,brain3,brain4,brain5,brain6}, the effect of brain tissues with different thicknesses, type and ages on the entangled state has been investigated. High-precision protein concentrometry and tomography of the biological samples such as onion-skin tissue have been done through entangled photons in Refs.~\cite{proteinconcentration} and \cite{octbiology}, respectively. More interestingly, in Ref.~\cite{human} the authors have shown that the Rod cells which respond to individual photons in the human cornea can detect a single-photon incident on with a probability significantly above chance.
But, in all of them they have not provided any practical optical parameter to characterize the target sample.

Inspired by the above-mentioned investigations, and using the extension of the Klyshko method \cite{klyshkoEfficiency} we are motivated to measure the transmittance of DNA and Methylene-Blue (MB) solutions through frequency-entanglement, as a practical meaningful optical parameter unlike the Refs.~\cite{brain1,brain2,brain3,brain4,brain5,brain6,proteinconcentration,human,octbiology}.
In cancer therapy and genetic sciences, the measurement of DNA concentrations, identification/detection of the different types of DNAs or even diagnosis of DNAs with different concentrations are essential to biologists and medicines. Furthermore, the MB with different doses as a disinfectant is very important in surgeries.
Very recently, it has been shown \cite{drug1} a drug developed by Boxin (Beijing) Biotechnology Development LTD based on MB photochemical technology, the so-called BX-1 drug, can inactive lipid-enveloped viruses such as HIV-1 in plasma with high efficiency and without damage to other components in the plasma as a safe and reliable method in clinical trials of HIV treatment. In addition, it has been challengingly confirmed the inactivation effect of BX-1 in SARS-CoV-2 \cite{drug1}. In Ref.~\cite{drug1}, the authors have argued that BX-1 can effectively eliminate SARS-CoV-2 within 2 mins and the virus concentration (titer) decreases and can reach 4.5 log10 $ \rm TCID_{50} $/ml (fifty-percent tissue culture infective dose which is the measure of infectious virus titer). The authors have also argued that BX-1 is safe for blood transfusion and plasma transfusion therapy in recovery patients, and the inactivated vaccine preparation has great potential for treatment in the current Coronavirus outbreak \cite{drug1}. That is one reason we are interested in MB and DNA as a biological and medical/chemical solution samples for its transmittance measurement vs concentration.
Despite of the quantum spectroscopy, here, the frequency of twin-photons are far from the absorption frequency of the samples which means that it needs no monochromators or very notch filters.
In the following, as an application of quantum measurement in biology we have shown that how a simple method based on the coincidence-count rate measurement of the generated frequency-entangled twin-photons beam due to the type-I SPDC in nonlinear BBO crystal which pass through DNA-and Methylene-solutions enables us to quantum measurement of the transmittance with $ \% 0.01 $ uncertainty \textit{without} any advanced or sub-pixel data analysis.
\textit{Interestingly}, through the quantum transmittometry Human-/Rabbit-DNA solutions with different concentrations $ \sim (0.01-100) \rm ng/\mu l $ have been detected.
The DNA solutions with concentrations in order of $ 0.01$ and $0.1  \rm ng/\mu l $ never can be detected by the standard (conventional) commercial spectrometer devices while we could detect them by CC- or transmittance-measurement with more than at lest 10-standardeviation.
\textit{Surprisingly}, in the same concentration we could distinguish/identify the Human-DNA and Rabbit-DNA solutions via their CC rates which never can be distinguished by classical methods such as single-count measurements. Furthermore, the same procedure has been performed to MB which led to detection of a very diluted Methylene solutions with concentrations $ \sim 4.5 \rm pg/\mu l $ through its quantum transmittometry.
Finally, the transmittance of some known physical thin-films on soda-lime are measured, that because of similarities to biological tissues, it points out that the introduced method may be applied to cancer-tissues or Stem Cells towards quantum diagnosis.

The paper is organized as follows. In Sec.~(\ref{theory}), we review shortly on the physical model of the SPDC and their PM equations. Also, in this section we show that the output of the SPDC is an frequency-entangled state. The experimental setup, methods and results are discussed in Sec.~(\ref{experiment}).
Finally, we summarize our conclusions and discuss our outlooks in Sec.~(\ref{summary}) .

\section{Theoretical model and description} \label{theory}
However, there is a large texts on the SPDC physics with more details, but, here in this section, we again would like to review short on the SPDC physics to better understanding of the readers especially in the field of biology.

\subsection{Two-particle entangled state}
Entanglement which has no classical counterpart plays the key role in the quantum technologies as the second revolution of the quantum theory during these decades. The best definition which can quantify the entangled state is non-separable property of a quantum state. Let us consider a pure state for a system composed of two spatially separated subsystems 1 and 2 which are closed:
\begin{eqnarray} \label{density1}
&& \hat \rho= \vert \Psi \rangle \langle \Psi \vert , \qquad  \vert \Psi \rangle=\sum_{a,b} \mathcal{C}(a,b) \vert a \rangle \vert b \rangle ,
\end{eqnarray}
where $ \hat \rho $ is the density matrix operator, $ {\vert a \rangle} $ and $ {\vert b \rangle} $ are two sets of orthogonal vectors for subsystems 1 and 2, respectively.
If $ \mathcal{C}(a,b) $ cannot be factored into a product of the form $ f(a) \times g(b) $, then, the state of the system is non-separable, and thus
\begin{eqnarray} \label{nonseparable1}
&& \hat \rho \neq \hat \rho_1 \otimes \hat \rho_2 ,
\end{eqnarray}
which means that it is an entangled state \cite{shySPDC}, as was defined for the first time by Schr{\"o}dinger.
The first simplest example known as the Einstein-Podolsky-Rosen (EPR) state is given by \cite{epr2}
\begin{eqnarray} \label{EPRstate}
&& \vert \Psi \rangle=\sum_{a,b} \delta(a+b-\alpha_0) \vert a \rangle \vert b \rangle,
\end{eqnarray}
where $ a $ and $ b $ are the momentum or the position of particle 1 and 2, respectively, and $ \alpha_0 $ is a constant.
As can be seen the value of momentum or position is determined for neither single subsystem. Also, the Dirac delta function indicates if one of the subsystems is measured to be at a certain value for that observable the other one is $ \% 100$ determined independent of their distance.

The \textit{Bell} states (or EPR-Bohm-Bell states), which are the most popular entangled two-particles state, are a set of polarization states for a pair of entangled photons.
They can be represented by
\begin{subequations} \label{Bell1}
	\begin{eqnarray}
	&&  \vert \phi_{12}^{(\pm)} \rangle=  \frac{1}{\sqrt{2}} [ \vert 0_1 0_2 \rangle \pm \vert 1_2 1_1 \rangle ],\\
	&&  \vert \psi_{12}^{(\pm)} \rangle=  \frac{1}{\sqrt{2}} [ \vert 0_1 1_2 \rangle \pm \vert 1_2 0_1 \rangle ],
	\end{eqnarray}
\end{subequations}
which form a complete orthonormal basis for polarization of light. $ \vert 0 \rangle $ and $  \vert 1 \rangle $ represent the two orthogonal polarization bases, for example, horizontal and vertical linear polarization, respectively. Note that in Eq.~(\ref{Bell1}) the two-photon space-time wavepackets have been ignored. Here, it should be emphasized that to experimentally prepare the Bell states one must overlap these two wavepackets \cite{polarizationentanglement1995,nonlocal4}, i.e., to make them quantum mechanically \textit{indistinguishable}, to keep valid the quantum state \textit{superposition} in Eq.~(\ref{Bell1}).

\subsection{SPDC as a source of two-photon entangled-state}
In nonlinear optical process of SPDC \cite{klyshkobook}, when a coherent pump laser beam is incident onto an optical nonlinear material with second-order nonlinearity, susceptibility $ \bar {\bar \chi}^{(2)} $, a pair of signal-idler photons, the so-called twin-photons, is generated with an efficiency in order of $ 10^{-7}-10^{-11} $.

Using the first-order perturbation theory together considering the second-order nonlinear interaction Hamiltonian of the SPDC, after some algebraic manipulations the state of the SPDC can be obtained as follows (for more details see Ref.~\cite{shySPDC})
\begin{subequations}  \label{spdcstate1}
	\begin{eqnarray}
	&& \vert \Psi \rangle_{\rm SPDC} \simeq - \frac{i}{\hbar}  \int   dt   \mathcal{\hat H}_{int}    \vert 0 \rangle   \nonumber \\
	&&  = \sum_{s,i} \delta (\omega_p -\omega_s -\omega_i) \Phi(\Delta_k L) \overbrace{ \hat a_s^\dag(\textbf{k}_s) \hat a_i^\dag (\textbf{k}_i) \vert 0 \rangle }^{\vert k_s \rangle \vert k_i \rangle}  \label{spdcstate1a}  \\
	&&  = \! \! \!  \int \! \! \!  g(\omega_p) d\omega_p \!\! \int \!\! d\omega_s f(\omega_p,\omega_s) \overbrace{ \hat a_s^\dagger(\omega_s) \hat a_i^\dagger(\omega_p-\omega_s) \vert 0 \rangle }^{\vert \omega_s \rangle \vert \omega_i \rangle}  \label{spdcstate1b},
	\end{eqnarray}
\end{subequations}
where $ \omega_j $, $ \textbf{k}_j $ ($ j=p,s,i $) are the frequency and wavevector of the signal ($ s $), idler ($ i $), and pump
($ p $) photons, respectively, and also $ \hat a_s^\dag $ ($ \hat a_i^\dag $) is creation operator for signal (idler) photon. Note that $ \omega_p $ and $ \textbf{k}_p $ can be considered as constants. $ g(\omega_p) $ and $ f(\omega_s,\omega_i) $ are the spectral amplitudes of the pump and signal-idler beams, respectively, which usually determined by the wavevector phase-matching condition of the SPDC and provide all information about the spectrum and the correlation properties of the signal-idler pair under the pump photons.
The sinc-like function $ \Phi(\Delta_k L) $ shows the effect of the finite length of the crystal ($ L $) which is given by \cite{shySPDC}
\begin{eqnarray} \label{sincdunction}
&& L \Phi(\Delta_k L)= \int_0^L dz e^{i\Delta_k L} \frac{e^{i\Delta_k L}-1}{(i\Delta_k L)},
\end{eqnarray}
where $ \delta_k= k_p-k_s-k_i $. It is easy to show that in the ideal case, infinite length, $ \Phi(\Delta_k L) \to \delta (\textbf{k}_p-\textbf{k}_s-\textbf{k}_i) $, and thus, the state of the SPDC can be simplified as
\begin{eqnarray} \label{SPDCstatefinal}
&&  \vert \Psi \rangle_{\rm SPDC} \simeq \sum_{s,i} \delta (\omega_p -\omega_s -\omega_i) \delta (\textbf{k}_p-\textbf{k}_s-\textbf{k}_i)  \vert k _s \rangle \vert k_i \rangle.
\end{eqnarray}
The first Dirac delta in the SPDC state implies on the energy conservation and the latter implies on the momentum conservation.
More surprisingly, compared to Eq.~(\ref{EPRstate}) the signal-idler two-photon SPDC state of Eq.~(\ref{SPDCstatefinal}) is an EPR type \textit{entangled}-state only because of the delta functions due to phase-matching. It is obvious that it cannot be factorized into a product of the signal and the idler photon state.
By looking at the space-time projection of the state which is equivalent to a Fourier transform, for a
pictorial view of the effective two-photon wavefunction, or wavepacket or \textit{biphoton}, one can emphasize this important physics of this EPR-type-entanglement of the two-photon SPDC-state (for more details see Ref.~\cite{shySPDC}).

Here, it is worthwhile to remind that the biphoton state which is an EPR-type entangled state is also usually the so-called `\textit{frequency}-entangled' state \cite{shySPDC,quantummetrologybook} (for better understanding see Eqs.~(\ref{spdcstate1a}) and (\ref{spdcstate1b})). Furthermore, one should emphasize that the concept of the biphoton or signal-idler pair photon or twin-photon is never what usually people think, i.e., the two individual independent photons.
\\

\subsection{Phase-matching equations}
The two delta functions in biphoton state of Eq.~(\ref{SPDCstatefinal}) which are the so-called the \textit{phase-matching} (PM) equations determine the energy of the signal-idler pair photons and what they `looks' like and how propagate in space-time. For example, in type-I PM in a negative uniaxial NLC, a linearly polarized pump laser beam as an extraordinary ray under the PM condition can generate a signal-idler pair which both are polarized as the ordinary rays while in the type-II, a signal-idler pair with one ordinary polarization and another extraordinary polarization are generated (for more details see Refs.~(\cite{shySPDC,phasematchBBO,phasematchPPKTP}). The PM equations, the energy-momentum conservation, can be written as
\begin{eqnarray} \label{pm1}
&& \omega_p=\omega_s + \omega_i ,   \qquad    \textbf{k}_p=\textbf{k}_s + \textbf{k}_i .
\end{eqnarray}
In our case, the planar type-I SPDC in which the signal-idler pair have the same ordinary ($ o $) polarization and pump has extraordinary ($ e $) polarization, the PM conditions can be simplified as follows \cite{shySPDC,phasematchBBO}
\begin{eqnarray} \label{pmfinal}
&& \! k_s(\lambda_s) \! \sqrt{1\! -\left(\frac{\sin\theta_s^{out}}{n_o(\lambda_s)}\right)^2} \! + \! k_i (\lambda_i) \sqrt{1 \!-\left( \frac{\lambda_i}{\lambda_s}\frac{\sin\theta_s^{out}}{n_o(\lambda_i)}\right)^2} \! \! =  \! k_p(\lambda_p,{\rm  \psi}), \nonumber \\
\end{eqnarray}
where $ \lambda_i= \lambda_s \lambda_p / (\lambda_s - \lambda_p) $, $ k_j(\lambda_j)=2\pi n_o (\lambda_j)/\lambda_j $ with $ j=s,i $ and $ k_p(\lambda_p,\rm \psi)= 2\pi n_{\rm eff} (\lambda_p,\rm \psi)/\lambda_p  $. The type-I tuning curves, outside angles versus wavelength, for a NLC can be theoretically plotted using Eq.~(\ref{pmfinal}). Note that the output angles $ \theta_{s,i}^{out} $ are the angles between the pump wavevector $ \textbf{k}_p $ and the signal or idler output beam from the end-side of the crystal. Also, $ \rm \psi $ is the angle between the pump wavevector with the OA inside the crystal.
It should be noted that the refraction indexes can be calculated from the Sellmeier equations \cite{shySPDC,phasematchBBO,boyd,agrawal} as follows
\begin{eqnarray}
&& n_j(\lambda_j)= \sqrt{L_1 + \frac{L_2}{\lambda_j^2 - L_3} - L_4 \lambda_j^2},  \qquad  (j=e,o)
\end{eqnarray}
where coefficients $ L_m $ ($ m=1,2,3,4 $) are determined experimentally (for example in the case of BBO crystal see Ref.~\cite{bbocoefficient}).
Furthermore, we emphasize that the refractive index for the $ e $-ray also depends on the angle $ \varphi_e = \rm \psi - \theta_s^{int} $ which can be found from Snell's law as $ \sin \theta_s^{int}= \sin \theta_s^{out}/n_o(\lambda_s)$. Therefore, we need to use the effective refractive index for all $ e $-rays (here in our case, \textit{e}-ray is only the pump beam $ p $) which is given by \cite{shySPDC,phasematchBBO,boyd,agrawal}
\begin{eqnarray} \label{n_eff}
&& n_{\rm eff} (\lambda_e, {\rm \psi})= \left[ \frac{\cos^2 \varphi_e}{n_o^2(\lambda_e)} +\frac{\sin^2 \varphi_e}{n_e^2(\lambda_e)} \right]^{-\frac{1}{2}}.
\end{eqnarray}

\subsection{Coincidence count rate}
The joint detection counting rate of detectors $ \rm D_1 $ and $ \rm D_2 $ (for example the first detector is in signal-arm and the other one is in the idler-arm), which is also known as the coincidence count (CC) $ R_c $, on the acquisition time interval $ T $, is the time-integrals over the biphoton wavepacket $ \Psi_{Bp}(r_1,t_1;r_2,t_2) $ as follows \cite{shySPDC}
\begin{eqnarray} \label{r_c1}
&& R_c \! \propto  \! \frac{\eta_1 \eta_2}{\rm T} \! \! \! \int_0^T \! \! \! \!\! \int_0^T  \!\! \! \!  dt_1 dt_2  \vert  \overbrace{ \langle 0 \vert E_2^{(+)}(r_2,t_2) E_1^{(+)}(r_1,t_1) \vert \Psi \rangle_{\rm SPDC }}^{\equiv \Psi_{Bp}(r_1,t_1;r_2,t_2)} \vert^2 ,
\end{eqnarray}
where $ E_j^{(+)}(r_j,t_j)=\int d\omega \hat a(\omega) {\rm exp}[-i(\omega t_j-k(\omega)r_j)]  $ ($ j=1,2 $) is the positive-frequency component of the field operator at detector $ \rm D_j $ with quantum efficiency $ \eta_j $.
It should be noted that the CC rate can be seen as a criterion for quantum correlation or frequency-entanglement in SPDC systems which reads a counting statistics. Note that in the SPDC-based experiment we usually measure the CC rate to exploit the entanglement. \\

Now, it is worthwhile to illustrate the relation between the CC rate as an experimental quantity and the second-order correlation function $ g^{(2)}(\tau) $, as a photon counting statistics criterion in the theoretical point of view which is given by
\begin{eqnarray} \label{g2}
&& g^{(2)}(\tau)= \frac{\langle \hat a^{\dag}_s(t+\tau) \hat a^{\dag}_i(t) \hat a_i(t) \hat a_s(t+\tau)  \rangle}{\langle \hat a^{\dag}_s(t+\tau) \hat a_s(t+\tau) \rangle  \langle \hat a^{\dag}_i(t) \hat a_i(t) \rangle  }  \quad .
\end{eqnarray}
The correlation function is proportional to the probability of detecting one signal-photon at time $ t + \tau $, given that another idler-photon was detected at earlier time $ t $. $ \tau $ is the delay time of detection between the idler and signal arm in output of the SPDC.
When $ g^{(2)}(\tau) < g^{(2)}(0) $, the photons tend to distribute themselves preferentially in bunches rather than at random (photon bunching). On the other hand, if $ g^{(2)}(\tau) > g^{(2)}(0) $, fewer photon pairs are detected close together than further apart (photon antibunching).
Using the quantum moment factoring theorem or the Gaussian properties of the noise forces and the quantum regression theorem (see Ref.~\cite{factorizationcite}), the correlation function can be simplified as follows
\begin{eqnarray} \label{g2factor}
&& g^{(2)}(\tau)= 1 + \frac{ R_{si} R_{is}}{R_s R_i} ,
\end{eqnarray}
where $ R_{s(i)}=\langle a^{\dag}_{s(i)}(t) a_{s(i)}(t) \rangle $ is the signal(idler) photon generation rate, and $ R_{si}= R_{is}^\ast=\langle a^{\dag}_{s}(t+\tau) a_{i}(t) \rangle $ is the cross-correlation rates or signal-idler correlation rate.
In Eq.~(\ref{g2}) we have assumed an infinite time resolution of the photon detector and ideal efficiency of the detectors.
However, in practice in lab, in the detectors, one can only resolve photons in a finite time window $ \tau_w $.
In the optical frequency, the time resolution is generally within a nanosecond while in microwave is of the order of a microsecond because Raman-absorption and arrival time cannot be distinguished that it sets the length of the detection time window.
The finite time resolution of the detectors imply that the second-order correlation function is usually a piecewise function as
\begin{eqnarray} \label{g2simple}
&& g^{(2)}(\tau_j)=1 + \frac{\int_{\tau_j}^{\tau_j+\tau_w} \vert R_{si} (\tau)\vert^2 d \tau}{R_s R_i \tau_w},
\end{eqnarray}
in which $ \tau_{j+1}=\tau_j +\tau_w $ and can be rewritten as
\begin{eqnarray} \label{g2final}
&&  g^{(2)}(\tau_j):= \frac{R_{cc}(\tau_j)}{R_{acd}}= \frac{R_s R_i \tau_w + \int_{\tau_j}^{\tau_j+\tau_w} \vert R_{si} (\tau)\vert^2 d \tau}{R_s R_i \tau_w} ,
\end{eqnarray}
where the generalized CC rate $ R_{cc}(\tau_j) $ includes two parts: the accidental rate $ R_{acd}=R_s R_i \tau_w $, and the correlated CC rate which contains the contribution of cross-correlation of the signal-idler which is also proportional to $ R_c $ in Eq.~(\ref{r_c1}).
It should be noted that what we measure in the Lab usually is $ R_c $ in Eq.~(\ref{r_c1}) which can be related to the second-order correlation function or counting statistics through Eq.~(\ref{g2final}).

\section{Experimental results \label{experiment}}
In this section, we are going to proceed with our experimental results, quantum measurement of the transmittance of the different samples such as DNA, MB and thin-films. Also, we compare the obtained transmittance via the CC-measurement to the SC measurement, as a classical-like measurement, which clarifies the advantage of entanglement-based measurement.

\subsection{Experimental Setup and Adjustments}
Schematic illustration of our experimental arrangement has been shown in Fig.~\ref{fig1}(a).
A $ 180{\rm mW} $ Gaussian beam of a $ 405{\rm nm} $ diode laser with $ \varnothing 3.8 \rm mm$ after passing through a diaphragm SP1, acting as a spatial filter, passes through a HWP [Newlightphotonic: WPA03-H-810, air-spaced 0th-order waveplate at 810nm, $\varnothing $15.0mm, and OD 1" mounted] to satisfy the PM condition.
For achieving this, we have set the HWP to $ +3.5^{\circ} $ to have  horizontally e-polarize pump beam. The e-polarized pump beam is reflected from two broadband (380-420nm) high-reflective ($  R>\%99.0 $) mirrors M1 and M2 [Newlightphotonic: BHR10-380-420-45; AOI 45 deg, $ \varnothing $25.4mm] and then passes through the SP2. After SP2, the horizontally \textit{e}-polarized pump beam has power around $ 85{\rm mW} $.
The pump beam is incident vertically on the single BBO type-I crystal [Newlightphotonic: NCBBO5050-405(I)-HA3] with Size $ (5 \times 5 \times 0.5){\rm mm} $, cut only for type-I PM SPDC and pumped by 405nm diode laser with the half opening angle of 3 degrees, and also AR coated with OD 1" mounted.
Based on the information of the manufacturer company when the pump beam are incident vertically on the entrance-side of the crystal the angle between pump wavevector and the OA is around $ \rm \psi=29.3^\circ $. In this manner, the frequency-entangled signal-idler pair are generated in planer case at output angles around $ \theta_s=\theta_i\simeq 3^\circ $.
The down-converted photons after passing through an uncoated long-wave pass red filters LPFj ($ j=1,2 $) [Newlightphotonic: LWPF1030-RG715; cutoff wavelength 715nm, $ \varnothing $25mm] by the fiber coupler lenses FCj ($ j=1,2 $) [Thorlabs: PAF2A-11B; FC/APC, f=11.0 mm, 600-1050 nm, $ \varnothing $2.38 mm waist] are focused into the multimode fibers MMFj ($ j=1,2$) [Excelitas: SPCM-QC9FIBER-ND 100 FC], and then transferred via the couplers into the 4-channel single-photon counting module (SPCM) [Excelitas: SPCM-AQ4C; dark counts 351, 483, 156, 146 cps for channels A,B,C, D respectively, time resolution 600ps, dead-time 50ns and quantum efficiency about $ \% $28 at 810nm].
To obtain the CC rate of the D1 and D2 we have used the coincidence counter module which we have made it using Altera-DE2 FPGA board and has coincidence time window $ \tau=7.1 $ns with adjustable acquisition time greater than 0.1s. To make sure its validity and also to calibration, we have compared it to the 8-channel coincidence-counter/time-tagger made by QuTools Co. [with time resolution (bin-size) and time-stamp 81ps] such that we found their SCs and CCs were in good agreement.
After online calculations via the C++ software in our CC module, the CC and SC rates fed to the PC and shown online in the Labview interface panel on the monitor. All the analysis of the experimental data has been done in MATLAB software. Finally, to decrease the background noises we have tried to remove all the reflected and scattered light from the environment and blocked the pump beam after crystal by blocker B. Moreover, we control the temperature of the Lab during each experiment.
Furthermore, to keep laser power constant to avoid noise in count rates, we stabilized the diode laser by a 5V 1A driver with $ \lesssim \% 0.1$ current-fluctuation which results $ \lesssim \% 0.1 $ power-fluctuation by assumption constant load on the adapter.
The distance between two detectors is about 120mm and the distance between detectors and BBO NLC is roughly 98cm.
To calibration and have the optimum PM and maximum CC rate we follow these steps before adding the samples:

(i) tuning the incident angle and polarization of pump beam to have stable maximum CC rate;

(ii) adjusting, tilting and moving detectors and BBO crystal which is on tiltable/rotatable mount. Note that the entrance port of the detectors (filter + coupler + entrance edge of fiber are fixed together on a holder as one element) is in the rotatable and movable mechanical elements.

After calibration and achieving the stable maximum CC rates, samples (DNA or MB solutions and thin-films on soda-lime) are added into the setup in the signal-port. The signal beam propagates and transmits through the samples and then reaches to the D2. In this condition, the CC and also SC rates are affected by the transmittance of the samples $ \mathcal{T} $ which depends on the concentration of the solutions or refractive index of the thin-film samples. In the following we show how can measure the transmittance $ \mathcal{T} $ via the CC rate and SC rate as a result of quantum entanglement and classical-like measurements, respectively, to characterize and detect the samples.

\begin{figure}
	\centering
	\includegraphics[width=13cm]{1.pdf}
	\caption{(Color online)  (a) Schematic illustration of the experimental arrangement for quantum measurement of the transmittance of DNA and Methylene-Blue solutions which are inside the glass cuvette and also thin-film samples. (b) Schematic of DNA chain and Methylene- Blue molecule. (c) Top-view of the experimental setup. (d) Different solution samples of Methylene-blue inside Erlen and frozen DNA-solutions with different concentrations inside the micro-tubes at $ -20^{\circ}  {\rm C}$. }
	\label{fig1}
\end{figure}

\subsection{Samples Preparation}
DNA is the first sample which we are interested in with different concentrations (see Fig.~\ref{fig1}(b)).
DNA (Deoxyribonucleic acid) is a molecule composed of two chains or strands that are intertwined and wrapped around each other to form a double helix carrying genetic instructions which are responsible for the development, functioning, growth and reproduction of all known organisms and many viruses and plays the key role in genetics.
These strands are also known as polynucleotides and composed of simpler monomeric units called nucleotides.
Each nucleotide includes one of four nitrogen-containing nucleobases (cytosine [C], guanine [G], adenine [A] or thymine [T]), a sugar or deoxyribose, and a phosphate group. We choose two different types of DNA, a Human-muscle and a Rabbit-muscle DNA solutions with different concentrations. These samples have been prepared by a PCR (Polymerase Chain Reaction) device. We have prepared Human DNA solutions with concentrations $ 0.01,0.1,1,10 $ and 100 $ { \rm ng/\mu l}$ and Rabbit solution with concentration 100$ { \rm ng/\mu l}$. Prepared samples have been identified via their transmittance using UV-IR Thermo 200C Spectrophotometer device by manufacturer (Neda Chemistry Co.) It should be noted that using the Thermo 200C Spectrophotometer device DNA solutions with concentrations less than 1$ { \rm ng/\mu l}$, we have called it the standard limit (SL) of this device, never can be detected and distinguished. In the other words, our DNA solutions with concentrations 0.01 and 0.1 $ { \rm ng/\mu l}$ never can be detected and identified via their transmittances by the standard commercial spectrometer device Thermo 200C. The prepared samples should be maintained at $-20^\circ \rm C $.

MB [$ \rm C_{16} H_{8} Cl ~\! N_3 S $] with different concentrations is the second type of our sample (see Fig.~\ref{fig1}(b)). Its different doses act as a disinfectant. We prepare the master sample by adding 1.5g MB  in 100ml Ethanol. After that, by adding Ethanol into master Methylene-blue (MMB) one can dilute it and the different concentrations $ 1.5 \rm \mu g/\mu l- 4.5 pg/\mu l$ are prepared to use.

Finally, we prepared some different dielectric thin-films: soda-lime glass without thin-films and also Al and Cr single metal layer and multilayers such as 3-layers $ \rm MgF_2/ZnS/MgF_2 $ and 4-layers $  \rm MgF_2/ZnS/MgF_2/ ZnS $ on the soda-lime glass.
We prepared Cr/Al nano layers by DC-sputtering coating (by MSS110 DC-Sputtering assisted turbo molecular pump  device made by ACECR in IRAN) on soda-lime glass slides at final vacuum pressure $ 1 \times 10^{-5} $mbar, Ar work-pressure $ 6.6 \times 10^{-3} $mbar, deposition rate $ 3.5 \rm A^{o}/s $, 7SCCM Ar gas, and with current 120mA and voltage 500v at temperature $ 100 ^o C $ around the substrate.
For the dielectric multilayers we used evaporation method (by EDS110 device assisted diffusion pump made by ACECR) at final vacuum pressure $ 8 \times 10^{-6} $mbar with deposition rate $ 1\rm A^{o}/s $. Here, all thickness have been obtained by the piezo crystal during the coating process with around $\%  10$ accuracy.

In our experiments, DNA and MB solutions are inside the glass cuvette (see inset in Fig.~\ref{fig1}(c)). Also, the thin-films are placed in mount. The cuvette and mount can be fixed on the tiltable and rotatable sample-holder which is placed in the signal-arm in the nearest distance to D2 such that the signal photons incident vertically on the cuvette or thin-film surface and thus transmit without any refraction. To sure it, we couples a 120mW 810nm-diode laser to the fiber coupler FC2 from the back in the signal-port, D2, and try to tilt and rotate the samples to retroreflect incident test-beam 810nm on itself.

At this point, the setup is ready to measurement of the transmittance (see Fig.~\ref{fig1}(c) which shows the top-view of experimental arrangement and Fig.~\ref{fig1}(d) shows the MMB and diluted MMB inside Erlen and also freezed DNA solutions inside microtubes. The inset shows a diluted MB inside cuvette in front of the D2). In the next subsection, we introduce our simple and short method to measurement of the transmittance.

\subsection{Method}

As mentioned, the samples with transmittance $ \mathcal{T} $ are placed in the signal-arm or sample-arm.
Interestingly, since the absorption frequency of our samples is roughly far from the signal-idler wavelength 810nm, then in contrast to the quantum spectroscopy, we need no monochromators and narrow-band filters to add in our setup. Therefore, one can assume and sure that all changes in the CC or SC rates is only and mostly due to the transmittance of the samples because of the changes in their refractive index or concentrations. In this manner, using the quantum correlation, i.e., CC rate, we have
\begin{eqnarray} \label{trans1}
&& \eta_2 \mathcal{T}_{cc}= \frac{N_{cc}^{(s)}}{N_1^{(s)}},
\end{eqnarray}
where the quantum efficiency is given by $ \eta_2= N_{cc}^{(0)}/ N_1^{(0)}$ \cite{quantummetrologybook}. $ N_{cc}^{(s)} $ and $ N_{cc}^{(0)} $ are the CC rates in the presence and absence of the samples, respectively, while $ N_1^{(s)} $ and $ N_1^{(0)} $ are the SC rates of the idle-arm (which there is no sample in this arm) in the presence and absence of the sample in sample or signal-arm.
Keeping it in mind that the time average idler SC rate is approximately the same for both cases of the presence and absence of the sample S, i.e., $ \bar N_1^{(s)} \simeq \bar N_1^{(0)}= \bar N_1$. Therefore, the transmittance can be precisely measured using the following relation
\begin{eqnarray} \label{transexact}
&& \mathcal{T}_{cc}= \frac{N_{cc}^{(s)}}{N_1^{(s)}} \frac{N_1^{(0)}}{N_{cc}^{(0)}} ~ ,
\end{eqnarray}
which can be approximated as
\begin{eqnarray} \label{transapp}
&&  \mathcal{T}_{cc} \simeq \frac{N_{cc}^{(s)}}{N_{cc}^{(0)}} ~ .
\end{eqnarray}
In our experiments we use Eq.~(\ref{transexact}) to obtain the transmittance by calculating the time-dependent CC rate matrix from the experimental data versus acquisition time. To have error in transmittance measurement, we clearly can use the relation
\begin{eqnarray} \label{errorCC}
&& \frac{\Delta \mathcal{T}_{cc}}{\mathcal{\bar T}_{cc}}= \vert \frac{\Delta N_{cc}^{(s)}}{\bar N_{cc}^{(s)}} \vert + \vert \frac{\Delta N_{cc}^{(0)}}{\bar N_{cc}^{(0)}} \vert + \vert \frac{\Delta N_{1}^{(s)}}{\bar N_{1}^{(s)}} -  \frac{\Delta N_{1}^{(0)}}{\bar N_{1}^{(0)}} \vert  ~ .
\end{eqnarray}
The standard method for transmittance measurement, which is used in the standard commercial spectrometer devices, is measuring the transmitted intensity divide to incident intensity of light, which is fully classical method based on the intensity measurement of the light. Now, for comparison to the classical method for illustration of the advantage of the quantum correlation, frequency-entanglement, respect to the classical intensity measurement one can write a relation for transmittance based on SC rate measurement, which is seen as a best classical-like method, as follows
\begin{eqnarray} \label{transclassic}
&& \mathcal{T}_{sc} = \frac{N_{2}^{(s)}}{N_{2}^{(0)}} ~ , \qquad  \frac{\Delta \mathcal{T}_{sc}}{\mathcal{\bar T}_{sc}}= \vert \frac{\Delta N_{0}^{(s)}}{\bar N_{2}^{(s)}} \vert + \vert \frac{\Delta N_{2}^{(0)}}{\bar N_{2}^{(0)}} \vert ,
\end{eqnarray}
where $ N_{2}^{(j)} $ (j=s,0) are the SC rates of the signal-arm (sample-arm) in the presence and the absence of the samples.
Note that if one arm of the SPDC to be blocked, the state of the system to be approximately collapsed to a pure state and thus the other arm can be seen as a non-ideal single-photon source or heralded single-photon source \cite{quantummetrologybook,boyd}.
Therefore, if by measuring the second-order autocorrelation function via HBT-interferometry (Hanbury Brown and Twiss), one finds $ g^{(2)}(0) <0.1 $ the source is called the idea single-photon source \cite{quantummetrologybook,boyd}, otherwise if $g^{(2)}(0) <1 $ the source is a non-ideal single-photon source.
Therefore, we would stress that in principle $ \mathcal{T}_{sc} $ which is obtained by measuring the SC rate is more accurate than the measurement of the classical light beam intensity to obtain transmittance.

 It is worth to note that the classical analog of the CC measurement of entangled photons is a measurement based on the classically correlated light beam which can be prepared by Arrechi's disk \cite{arrechi} or spatially light modulator (SLM). Surprisingly, it has been shown theoretically and experimentally that the CC-based measurement of the entangled photons is much more accurate than its classical counterpart, CC measurement of classically correlated beam \cite{qillumination2,qillumination5}.
That is why here we are going to show the advantage and compare the transmittance measurement based on the CC measurement of entangled photons and SC-based measurement.

Finally, it should be noted that we have to take into account the well-known error corrections \cite{errorcorrectionBrida200} due to the accidental coincidence rate, dark count, and dead-time. The accidental rate, $ N_{Ac}=N_1 N_2  \tau_{cc}/T  $, and dark counts $ D_j $ ($ j=1,2 $) can be taken into account \cite{errorcorrectionBrida200} by substituting $ N_{cc}-N_{Ac} $ and $ N_j-D_j $ instead of experimentally recorded counts $ N_{cc} $ and $ N_j $, respectively. Another correction due to the dead time of the detectors can be taken into account by substituting $ \gamma N_j $ instead of $ N_j $ where $ \gamma $ is the dead time correction factor, $ \gamma=1- N_j \tau_{\rm dead}/T $ \cite{errorcorrectionBrida200}. Note that since single count in the sample arm is variable due to the present of the different samples, then its $ \gamma $-factor is not constant and changes in each case but is around 0.9.
Here, $ \tau_{cc} $, $ \tau_{\rm dead} $ and $ T $
are, respectively, the coincidence time window, the dead time of the detectors and the interval (integration) or gate time which in our case their values are, respectively, 7.1ns, 50ns and 0.3s. Other corrections factors which are discussed in Ref.~\cite{errorcorrectionBrida200} are ignorable in our setup.

\subsection{DNA results}

After calibration of the setup we checked our methods on DNA solutions with different concentrations $ \mathcal{C} $. The results of the transmittance measurement based on CC- or SC-count measurement on Human (H) and Rabbit (R) DNAs are given in Tab.~(\ref{tabDNA}).
Comparing the four last columns in Tab.~(\ref{tabDNA}) clearly shows that the errors due to transmittance measurement via the CC rate, as a quantum entanglement-based measurement, are very smaller than the SC measurement as a classical-like measurement.  Moreover, relative error ($  \Delta N/\bar N $) in CC rate is generally in order of $ 10^{-4} $ while in SC rate is in order of $ 10^{-3} $, i.e., the CC rates are 1-order more accurate than the SC rates. Furthermore, the average of transmittance obtained by both CC and SC rates is in very good agreement to each other which shows the self consistency of the method.

\begin{table*}

	\caption{ Experimental values for the transmittance measurement on DNA of Human (H)/Rabbit (R) hand-muscle with different concentrations based on the SC-measurement and CC-measurement. Here, during the experiment the temperature of the Lab is fixed at $ (18 \pm 0.1) ^{\circ} \rm C $. The acquisition time and coincidence time window are respectively $ T_{\rm acq}=0.3\rm s $ and $ \tau=7.1 \rm ns $. The average single-count rate of the idler-arm during the experiment is $ \bar N_1=(1.240 \pm 0.005) \rm Mcps $. Here, the CC and SC rates are vs count per second (cps) or Hz. Also, we define a figure of merit as an entanglement advantage respect to the single-count measurement in count rates as $ \mathcal{G}_{N}={\rm err}^{\rm rel} (N_2)/ {\rm err}^{\rm rel} (N_{cc}) $ and to transmittance measurement as $ \mathcal{G}_{T}={\rm err}^{\rm rel} (\mathcal{T}_{sc})/ {\rm err}^{\rm rel} (\mathcal{T}_{cc})  $ in which the relative error is defined as $ {\rm err^{rel}}(x)=\Delta x/\bar x $.Note that, here, the standard limit of concentration (SL) to detection or identification of DNA through its transmittance is defined as 1$ \rm ng/\mu l $ which is obtained by the standard commercial Thermo200c UV-spectrometer device by manufacturer.}

	\resizebox{\textwidth}{!}{
		\begin{tabular}{cccccccccc}
			\multicolumn{1}{c}{ Sample} & \multicolumn{1}{c}{ DNA }& \multicolumn{1}{c}{Concentration} & \multicolumn{2}{c}{ Count Rates
			} & \multicolumn{2}{c} {Transmittance} & \multicolumn{2}{c}{Ent. Adv. } \\

			$ \# $ & Type & $\mathcal{C}$ [$ \rm ng/\mu l $] & CC $  N_{cc}$[K cps] & SC $ N_2$[K cps] & $\mathcal{T}_{cc}$[$ \% $] & $\mathcal{T}_{sc}$[$ \% $] & $  \mathcal{G}_{T} $ & $  \mathcal{G}_{N} $ \\ \hline \hline

			$1$ & No.samp/cuv. & ----- & $107.17\pm0.05$ & $1005.172\pm0.721$ &  -----  & -----  & ----- & $1.52$ \\ \hline

			$2$ & R & $100$ & $90.28\pm0.05$ & $853.118\pm1.001$ &  $84.24\pm0.09$   & $84.89\pm0.16$  & $1.89$ & $1.87$ \\ \hline

			$3$ & H & $100$ & $91.50\pm0.03$ & $864.208\pm0.980$ &  $85.37\pm0.07$   & $85.98\pm0.16$  & $3.85$ & $3.84$ \\

			$4$ & H & $10$ & $92.53\pm0.01$ & $873.128\pm0.748$ &  $86.34\pm0.05$   & $86.86\pm0.13$  & $2.60$ & $6.43$ \\

			$5$ & H & $1$ (SL) & $93.28\pm0.01
			$ & $877.985\pm0.920$ &  $87.04\pm0.05$   & $87.35\pm0.15$  & $3.19$ & $13.42$ \\

			$6$ & H & $0.1$ & $94.16\pm0.03$ & $887.752\pm0.667$ &  $87.86\pm0.07$   & $88.32\pm0.13$  & $1.83$ & $2.24$ \\

			$7$ & H & $0.01$ & $94.90\pm0.04$ & $888.613\pm0.774$ &  $88.55\pm0.08$   & $88.40\pm0.14$  & $1.84$ & $2.24$ \\

		\end{tabular}

	}
	\label{tabDNA}
\end{table*}

By Comparing the second and the third row in Tab.~(\ref{tabDNA}), one can interestingly figure out the advantage of the use of entanglement or CC rate respect to use of SC rate. As is seen in Fig.~(\ref{fig2}) and Tab.~(\ref{tabDNA}), at the same concentration 100$ \rm ng/\mu l $ the Rabbit-DNA can be detected and distinguished from the Human-DNA by more than 30$ \sigma_{\rm st} $ and 13$ \sigma_{\rm st} $ via the CC rate and its analogous transmittance, respectively, while it can be detected by more than 9$ \sigma_{\rm st} $ and 4.8$ \sigma_{\rm st} $ using SC rate and its analogous transmittance, respectively.
This shows the entanglement or quantum correlation advantage to high-precision distinguishability between Human and Rabbit DNAs with the same concentration such that the CC-based measurement is approximately 3-times more accurate than the SC-based measurement.
As is seen in Fig.~\ref{fig2}(c) and (d) and H-rows in Tab.~(\ref{tabDNA}), below the SL of concentration ($ 1\rm ng/\mu l $ which is defined for DNA detection using transmittance measurement via standard spectrometer devices such as Thermo200C) the SC-based measurements never can detect DNA solutions with high reliability, we called it unreliable measurement region. While, surprisingly, using the CC-based measurement (transmittance or CC rate) one can detect and distinguish DNA solutions with high-reliability more than 20$ \sigma_{\rm st} $ and 8$ \sigma_{\rm st} $, respectively, via the CC rate and CC-based transmittance (see Fig.~\ref{fig2}(a) and (b)). In other words, frequency-entanglement enables us to ultra-precise measurement and high-accuracy distinguishability at least 2-order below the SL of DNA-concentration to diagnose and distinguish DNA with concentrations 0.01 and 0.1 $ \rm ng/\mu l $. From the experimental results in Tab.~(\ref{tabDNA}) it is clear that the CC-base measurement of the transmittance has 0.05 accuracy which is at least 3-times more accurate than the SC-based measurement of the transmittance.

\begin{figure}
	\centering
	\includegraphics[width=6.50cm]{2a.pdf}
	\includegraphics[width=6.50cm]{2b.pdf}
	\includegraphics[width=6.50cm]{2c.pdf}
	\includegraphics[width=6.50cm]{2d.pdf}
	\caption{(Color online) (a) and (c) Experimental CC and SC rate measurements for DNA solutions with different concentrations, respectively. (b) and (d) Experimental CC-based and SC-based transmittance measurement of DNA solutions vs their concentrations, respectively. Here, the thick blue circle points and thick red triangle points are respectively referred to experimental data for the Human and Rabbit DNAs. Below the SL region the CC-base measurement results are very reliable in contrast to the SC-based measurement results. }
	\label{fig2}
\end{figure}

By considering the SNR definition as the signal to noise ratio \cite{mexico1,mexico2} and the sensitivity $ \mathcal{S} $ as the minimum noise in the system (see Ref.~(\cite{aliDCEBECforce}) and references therein) as
\begin{eqnarray} \label{snr}
&& \rm SNR= 10 {\rm Log}(\frac{P_{\rm signal}}{P_{\rm Noise}}) ~ , \qquad   \mathcal{S}=-10 {\rm Log} P_{\rm Noise}^{\rm min}
\end{eqnarray}
where the power of signal and noise is defined as their count rates ($ P_{\rm signal(noise)}:=N_{\rm signal(noise)} $).
Using the experimental results in Tab.~(\ref{tabDNA}), one can find the average SNR for the CC and SC rates as $\rm  SNR_{\rm Ent.}\simeq 36.5\rm dB $ and $ \rm SNR_{\rm SC}=30.3 \rm dB $, respectively. Moreover, the average sensitivity is respectively $ \mathcal{S_{\rm Ent.}}\simeq -14.2 \rm dB $ and $ \mathcal{S_{\rm SC}} \simeq -29.2 \rm dB $.
This clearly shows that in our experiment the CC-based measurements which are due to the frequency-entangled state of SPDC has 6dB SNR, and 15dB sensitivity more than the SC-based measurement. Furthermore, in case of transmittance measurement: $ \rm SNR_{\rm Ent.}^{T} \simeq 31.1 \rm dB $ and $ \rm SNR_{\rm SC.}^{T} \simeq  \rm 27.8dB $ which means 3dB more SNR is achievable using CC-based transmittance measurement. As is seen in Fig.~(\ref{fig2}), we should emphasize that different DNAs with different concentrations are reliably detectable and distinguishable from each other using the CC-based measurement with accuracy at least more than 10$ \sigma_{\rm st} $.

\begin{figure}
	\centering
	\includegraphics[width=10cm]{3.pdf}
	\caption{(Color online) Theoretical fitted curve to the experimental transmittance points of DNA obtained from the CC-measurement. }
	\label{fig3}
\end{figure}

In Fig.~(\ref{fig3}) the theoretical exponential model for transmittance vs concentration as
\begin{eqnarray} \label{t_fit}
&& \mathcal{T}_{\rm fit}= T_0 e^{- \mathcal{C}/\mathcal{C}_0} + T_{\infty} e^{- \mathcal{C}/\mathcal{C}_{\infty}}  ,
\end{eqnarray}
have been fitted to the experimental transmittance points obtained via the CC-measurements. Using this model which has good agreement in this concentration regime, one can estimate concentration of DNA solutions with unknown concentration. This may lead indirectly to high-accuracy DNA concentration measurement, concentrometry. If we assume $ \%  0.01$ uncertainty in experimentally transmittance measurement using the CC rate, one can expect $ 3\rm pg/\mu l $ uncertainty in concentration measurement, while in SC case the uncertainty in transmittance could be $\% 0.1  $ which results  $ 30 \rm pg/\mu l $ uncertainty in concentration measurement using SC rate. Although, we have focused on the transmittance measurement, but using the theoretical fitting curve in Eq.~(\ref{t_fit}), and preparing a database for some DNA solutions in different concentration regimes, one can indirectly measure concentration of DNA solutions via their CC-based transmittance measurement. Furthermore, the concentrometry using CC rate is more accurate than the SC rate notably below the SL which the SC-based measurement cannot work reliably. But, it is clear that the method works better and more accurate for the transmittance measurement instead of concentration measurement.

Finally, this introduced method in this subsection might be used to manufacture an entanglement-based transmittometer/concentrometer simple-device for DNA detection via the CC-measurement.

\subsection{MB results}

\begin{table}
	\caption{ Experimental values for the transmittance measurement on the Methylene-blue (MB) with different concentrations based on the SC-measurement and CC-measurement. Here, during the experiment the temperature of the Lab is fixed at $ (27 \pm 0.1) ^{\circ} \rm C $. Here, $ \bar N_1=(1.238 \pm 0.005) \rm Mcps $ and the other experimental parameters are the same as Tab.~(\ref{tabDNA}).}

	\resizebox{\textwidth}{!}{
		\begin{tabular}{cccccccccc}
			\multicolumn{1}{c}{ Sample} & \multicolumn{1}{c}{ MB }& \multicolumn{1}{c}{Concentration} & \multicolumn{2}{c}{ Count Rates} & \multicolumn{2}{c} {Transmittance} & \multicolumn{2}{c}{Ent. Adv. } \\

			$ \# $ & Type & $\mathcal{C}$ [$ \rm ng/\mu l $] & CC $  N_{cc}$[K cps] & SC $ N_2$[K cps] & $\mathcal{T}_{cc}$[$ \% $] & $\mathcal{T}_{sc}$[$ \% $] & $  \mathcal{G}_{T} $ & $  \mathcal{G}_{N} $ \\ \hline \hline

			$1$ & No.samp/cuv. & ----- & $59.87\pm0.03$ & $931.34\pm0.33$ &  -----  & -----  & ----- & ----- \\ \hline

			$2$ & MMB & $1.5\times 10^4 $ & $2.32\pm0.02$ & $32.13\pm1.23$ & $3.37\pm0.03$ &  $3.44\pm0.14$   & $1.02$  & $1.03$ \\ \hline

			$3$ & $ \rm S_0 $ & $4.5\times 10^3$ & $33.23\pm0.01$ & $506.56\pm1.39$ & $55.51\pm0.04$ &  $54.39\pm0.17$ & $4.58$ & $12.54$   \\ \hline

			$4$ & $ \rm S_1 $ & $15$ & $51.51\pm0.01$ & $809.26\pm1.84$ &  $86.04\pm0.06$ & $86.89\pm0.23$ & $3.81$ & $9.82$ \\

			$5$ & $ \rm S_2 $ & $1.5$ & $52.38\pm0.01$ & $820.02\pm1.58$ &  $87.49\pm0.06$   & $88.05\pm0.20$  & $3.37$ & $8.86$ \\

			$6$ & $ \rm S_3 $ & $0.15$ & $53.27\pm0.01$ & $828.51\pm1.47$ &  $88.97\pm0.06$   & $88.96\pm0.19$  & $2.96$ & $6.80$ \\

			$7$ & $ \rm S_4 $ & $0.075$ & $53.89\pm0.01$ & $840.56\pm1.80$ &  $90.00\pm0.06$   & $90.25\pm0.23$  & $3.56$ & $8.83$ \\

			$8$ & $ \rm S_5 $ & $0.045$ & $54.58\pm0.01$ & $847.24\pm1.68$ &  $91.17\pm0.06$   & $90.97\pm0.21$  & $3.42$ & $8.81$ \\

			$9$ & $ \rm S_6 $ & $4.5\times 10^{-3}$ & $55.42\pm0.01$ & $858.15\pm1.15$ &  $92.56\pm0.06$   & $92.14\pm0.16$  & $2.52$ & $6.22$ \\

		\end{tabular}

	}
	\label{tabMB}
\end{table}

Similar to DNA solutions, the same procedure have been performed on the MB solutions to obtain their transmittance vs concentration (see Tab.~(\ref{tabMB}) and Fig.~(\ref{fig4})). As is seen the transmittance obtained in both cases CC- and SC-based measurement are in good agreement. Similar to DNA case the CC-based measurements have more accuracy and more SNR concerning the SC-based measurement. For example, very diluted MB solution with concentration $ 4.5 \rm pg/\mu l $ and $\% 92 $ transmission has been detected through CC-based transmittance measurement with $ \rm SNR\simeq 37dB $ which is 9dB more than SC-based measurement. The physical conclusion in case MB is the same as DNA: the entanglement enables us to more accurate measurement of the transmittance of the diluted solutions with higher SNR and smaller noise.
The uncertainty in transmittance due to the CC and SC rate measurement is respectively, $ \%0.06 $ and $ \%0.17 $. It means that the CC-based measurement is more accurate and more reliable because of entanglement advantage. Moreover, using the fitting Eq.~(\ref{t_fit}) a $ 0.1 \rm pg/\mu l $ uncertainty is achievable using CC-based transmittance measurement due to the frequency-entanglement advantage.

\begin{figure*}
	\centering
	\includegraphics[width=6.50cm]{4a.pdf}
	\includegraphics[width=6.50cm]{4b.pdf}
	\includegraphics[width=6.50cm]{4c.pdf}
	\includegraphics[width=6.50cm]{4d.pdf}
	\caption{(Color online) (a) and (b) Experimental CC and SC rates for MB solutions with different concentrations, respectively. (c) and (d) Experimental CC- and SC-based transmittance measurement of MB solutions vs their concentrations, respectively. }
	\label{fig4}
\end{figure*}

Here, It should be reminded that as DNA case, one can manufacture an optical device based on frequency-entanglement to high precision measurement of the transmittance or indirect measurement of the concentration through the transmittance.

Furthermore, as we said in the previous section the maximum absorption wavelength of DNA and MB are about $ \lambda_{\rm DNA}^{\rm ab.}\sim 260\rm nm$ \cite{absorbDNA} and $ \lambda_{\rm MB}^{\rm ab.} \sim 668 \rm nm $, respectively, which are far from signal wavelength $ \lambda_{s}=810 \rm nm $ that passes through the sample. This means that our method for transmission measurement based on the CC rate measurement is still valid.

\subsection{Thin-films results: towards quantum diagnosis of cancer tissues}

To test our method for measuring the transmittance of the transparent bulk object, specially, thin-film (TF) samples, we proceed in this subsection to measure the transmittance of soda-lime glass, single- and multi-layer dielectric thin-films and also single metal layers using CC and SC rate measurement (see Tab.~(\ref{tabTF})).

To test the validity of our methods, we try to perform measurements on the Soda lime and Lamel glasses (see samples $ \#2 $ and $ \#3 $ in Tab.~(\ref{tabTF})).
Our transmittance results are in agreement with transmittance that we expect for soda-lime with thickness around 1mm and Lamel with thickness around 150$ \mu \rm m $ based on Ref.~\cite{refractivecite}(around $ \% $ 3(2)-4 absorption and $ \% $ 3(2)-4 reflection for soda-lime(Lamel) glass). Moreover, as is seen in Tab.(\ref{tabTF}) both transmittances using CC and SC measurement are in agreement but CC-based measurement has more accuracy than SC-based measurement.
Using the Fresnel coefficient for transmittance at near-normal incident as a rough model (ignoring the effects of absorption, interference and thickness), $ T=4n_{\rm air} n/(n_{\rm air} + n)^2 $, one can simply find $ n=1.677\pm 0.003 $ and $ n=1.530\pm 0.004  $ using the CC, respectively, for soda-lime and Lamel glasses. It seems in this method one can obtain the refractive index with accuracy in order of $ 10^{-3} $.

Samples $ \#4 $ and $ \#5 $ show the transmittance measurement of dielectric multilayers MgF2/ZnS on soda-lime in which MgF2 and ZnS layers have thickness around $\lambda_{\tiny {1064}}/4 $ with $ 10\% $ tolerance, respectively.
Their imaginary refractive index are $\tilde n_{\rm MgF2}^{\rm \lambda_s} = 1.4193 + \rm i 4.2103 \times 10^{-4}  $ with absorption coefficient $ \alpha_{\rm MgF2}^{\rm \lambda_s}=65.319\rm cm^{-1} $ and $\tilde n_{\rm ZnS}^{\rm \lambda_s} = 2.3256 + \rm i 0.027886  $ with absorption coefficient $ \alpha_{\rm MgF2}^{\rm \lambda_s}=4326.3\rm cm^{-1} $ \cite{refractivecite} which imply that their absorption wavelength is far from signal-wavelength or they are fully transparent for incident signal-idler wavelength $ 810 \rm nm $. As is seen in Tab.~(\ref{tabTF}), similar to solution cases both SC- and CC-based transmittance measurement are in agreement. However, it is clear that the CC-based measurement is more accurate.
Here we remind that in cases of glasses and multi-layers samples since the absorption wavelength are far from incident signal-wavelength, thus, our method works well as we expected.

Despite of this to show that our method as we expected cannot work well for absorber material like metals, we try to preform our method on Al and Cr nanolayers with thickness around 15nm and 25nm with $ 10\% $ precision, respectively. Note that both Al and Cr are good absorbers at wavelength 810nm which absorb more than $\% 50 $, especially Al. Refractive index of Al and Cr are, respectively, $\tilde n_{\rm Al}^{\rm \lambda_s} = 2.7670 + \rm i 8.2925  $ with absorption coefficient $ \alpha_{\rm Al}^{\rm \lambda_s}=1.2865 \times 10^6 \rm cm^{-1} $, and $\tilde n_{\rm Cr}^{\rm \lambda_s} = 3.1797 + \rm i 3.4698  $ with absorption coefficient $ \alpha_{\rm Cr}^{\rm \lambda_s}=5.3831 \times 10^5 \rm cm^{-1} $. As is seen in Tab.~(\ref{tabTF}), the results of transmittance based on CC and SC measurement has no agreement which is due to the absorption. In this manner, to have a precise and valid transmittance we need to put narrow-band filters or monochromator to receive exactly the re-emitted photon due to the absorption. That is why the results have no coincidence together.

Surprisingly, it should be noted that our most motivation to perform the method on the TFs is that the similarity between TFs and cancer tissues such as brain tissues which can be prepared as a thin-film on a slide. Therefore, it may be used for cancer therapy or diagnostic purposes. We are hopeful that in the soon future this simple method, which is based on the CC-measurement of generated frequency-entangled biphotons, opens a new pave and simple platform to cancer therapy and quantum diagnosis of cancer more accurate than the present classical methods in different types of cancer tissues.

\begin{table*}
	\caption{ Experimental values for the transmittance measurement of TFs. Here, the temperature of the Lab is fixed at $ T=(20 \pm 0.1) ^{\circ} \rm C $, and $ \bar N_1=(1.270 \pm 0.008) \rm MHz $. }

	\resizebox{\textwidth}{!}{
		\begin{tabular}{cccccccccc}
			\multicolumn{1}{c}{} & \multicolumn{1}{c}{ Sample } & \multicolumn{2}{c}{ Count Rates} & \multicolumn{2}{c} {Transmittance} & \multicolumn{2}{c}{Ent. Adv. } \\

			$ \# $ & Type & CC $  N_{cc}$[K cps] & SC $ N_2$[K cps] & $\mathcal{T}_{cc}$[$ \% $] & $\mathcal{T}_{sc}$[$ \% $] & $  \mathcal{G}_{T} $ & $  \mathcal{G}_{N} $ \\ \hline

			$1$ & No sample & $ 95.50\pm 0.04 $ & $ 933.35\pm 0.74 $ &  -----  & -----  & ----- & ----- \\
			$2$ & Soda Lam & $ 89.39\pm 0.01 $ & $ 869.99\pm 0.80$ & $ 93.61 \pm 0.05 $  & $ 93.21 \pm 0.16 $  & 3.50 & 7.01 \\
			$3$ & Lamel & $ 91.30\pm 0.02 $ & $ 893.63\pm 0.76$ &  $ 95.61 \pm 0.06 $  & $ 95.74 \pm 0.16 $  & 2.77 & 3.66  \\  \hline
			$4$ & MgF2/ZnS/MgF2/Soda Lam & $ 84.430\pm0.013 $ & $ 821.96\pm 0.49 $ &  $ 88.42 \pm 0.05  $ & $ 88.07 \pm 0.13  $ & 2.72 & 3.96\\
			$5$ & MgF2/ZnS/MgF2/ZnS/Soda Lam & $ 65.862\pm0.008 $ & $639.97 \pm 0.82 $ &  $68.97 \pm 0.03  $  & $ 68.57\pm 0.15$ & 4.39 & 10.44 \\ \hline
			$6$ & Al/Soda Lam & $ 16.320\pm 0.002 $  & $ 146.50\pm 0.37 $ & $ 17.09 \pm 0.01 $ & $ 15.70\pm0.05 $ & 7.23 & 25.78 \\
			$7$ & Cr/Soda Lam & $ 27.882\pm 0.004 $ & $ 250.51 \pm 0.50 $ &  $ 29.20\pm0.01 $  & $ 26.84 \pm 0.08 $  & 5.48 & 13.60 \\

		\end{tabular}

	}
	\label{tabTF}
\end{table*}

\section{Discussion}
Let us discuss more in this section to illustrate the ability of the introduced simple method.

\begin{itemize}
	\item[(a)]
	  A considerable difference of coincidence count (CC) rate by human- and rabbit-DNA solutions are actually just due to the difference of their transmittance which itself originates to difference of their refractive indexes at 810nm. It is very important to note that the absorption wavelength of DNAs is usually around 250-300nm \cite{absorbDNA} while our probe wavelength of the signal-idler biphoton is at 810nm which is very far from the absorption frequency of Rabbit and human DNAs.

	\item[(b)]
	It should be mentioned that the other important physical parameters which may influence or affect on the CC or SC rate are temperature, concentration and inhomogeneity of the solution during the measurement. To avoid the first one, we have fixed the temperature of Lab during the experiment, then, we are sure that any small difference of the CC/SC is just due to the difference of transmittance or small difference of refractive index.
	Furthermore, to avoid the second one, we requested from our genetic expert colleagues in Neda Shimi Ltd to prepare both human and Rabbit DNA with the same concentration as possible as.
	Finally, to avoid the effects of inhomogeneity, diffusion, and turbulence of the solutions during the measurement, after pouring solution in the cell, we waited for a certain time to be sure that there is no inhomogeneity, diffusion, and turbulence, and then, we start the data acquisition to obtain the transmittance.

	\item[(c)]
	 It should be noted that the introduced method can be applied to other solutions as far as the absorption wavelength to be far from the signal wavelength. Note that, by having a tunable source like PPKTP or PPLN SPDC sources, which exists in many Labs, one can always apply this method for any solutions or samples. Since it is just enough to tune the SPDC-pump to generate the output wavelength far from the absorption wavelength of the target solution. In this case, in addition to tunable source, one needs to a wide range single photon detectors. In other words, different samples cannot change the physics, and just change the values of the CC/SC rates and consequently the transmittances at desired wavelengths.

	 \item[(d)]
	 It should be emphasized that in the present work all transmittance-measurements are a \textit{relative} measurement with \textit{respect} to the prepared concentrations by our reference external molecular genetic Lab, Neda Shimi Co., not an absolute measurement. Furthermore, since our goal is transmittance measurement, then, we have not used or found a theoretical model for behavior of the transmittance vs concentration, temperature, and refractive index of the used samples. But, if we can find a convenient theoretical model similar to Refs.~\cite{concentrationModel1,concentrationModel2} whose authors provided the model versus concentration and temperature for Ethanol, thus, we are able to perform an absolute measurement which yields to absolute values of refractive index or concentration at the fixed temperature.
	 It would be a good future research plan with collaboration of chemists and geneticists to find a model for the behavior of the DNA and MB to apply the introduced method to obtain the absolute value of the refractive index and concentration.

	 Nevertheless, with no theoretical model, one can still prepare many solution samples with different concentrations at fixed temperature to prepare a database for their transmittance behavior. Then, one can find a trend for each sample versus its concentrations in the fixed temperature. Then, by calibration respect to the used concentration reference at the determined temperature, one can provide relatively concentration and refractive index of an unknown solutions with respect to the reference through their measured transmittance. This may lead to manufacture of a quantum-based device in the future.

	 \item [(e)]
	 Let us clarify the probable ambiguity that why we argue that the thin film multilayer results may lead to quantum diagnosis or application in medicine and biology in the future.

	 In Refs. \cite{brain1,brain2,brain3,brain4,brain5,brain6,proteinconcentration,octbiology,human}, the authors have investigated how much the brain tissue, biological objects, rat or kidney tissues can preserve the frequency-entanglement, polarization-entanglement and even recently the hyper-entanglement such as orbital angular momentum (OAM) which are very interesting from the philosophy and \textit{consciousness} point of view. Their motivations are usually to show that entanglement can be used to characterize these tissues and can be used to cancer therapy or diagnosis of the tissues, or quantum interpret of the brain of biological mechanism.
	 But, as far as we know, they have not provided a practical measure or quantity for this aim, except Bell parameter S or some well-known nonlocality parameter such entanglement entropies \cite{brain1,brain2,brain3,brain4} which quantify the entanglement.
	 While we have provided an optical parameter, transmittance, which can practically characterize the sample via its response to the quantum entanglement, nonclassical light. That is why we have been motivated to investigate the thin films samples, since we believe that it may open a new practical way to cancer therapy and quantum diagnosis in medicine and biology.

	 Let us now illustrate the relation or similarities/differences between thin films and cancer tissues or rat sections. As presented in mentioned Refs.~\cite{brain1,brain2,brain3,brain4,brain5,brain6,proteinconcentration,octbiology,human}, the rat sections or brain/kidney tissues with different thickness (10-600$ \mu  $m) are similar to a thin or thick films. But, usually the optical thin films or multilayers are homogeneous and uniform while these biological tissues with different thickness are inhomogeneous and scatterer which can be modeled theoretically by considering different scatterer layers. Although there are this differences between optical multilayers and biological films like brain/kidney/rat tissues, but the thin film model can still provide a rough approximate model to investigate the interaction of entanglement light source with these biological tissues.
	 That is another reason we have been motivated to perform our method on the thin film layers to measure their transmittance, and we believe that our simple quantum measurement approach can open a new platform to quantum diagnosis of biological tissues and its characterization as has been addressed in Refs.~\cite{brain1,brain2,brain3,brain4}.
	 Besides these, in Refs.~\cite{brain1,brain2,brain3,brain4} the authors have used the Bell parameter S and entanglement entropy measures which give no information about the materials, while if our method has been applied, then, transmittance measurement enables us to precisely characterize. Furthermore, they have used polarization-entanglement which is very fragile when light passing through the tissues while our frequency-entanglement biphoton is robustness with much higher rate. These are reasons we argue that the thin film results can open a way towards the quantum diagnosis, quantum therapy and also quantum characterization in the context of medicine and biology.

	 \item [(f)]
	One of the most important questions which can be addressed here is the genuine damage of a biological sample that may be caused due to its transmittance measurement process.
	Note that we \textit{never} have shown in this paper that a genuine damage is avoided in DNA or MB samples through the use of quantum correlations.  But, it is worth to remind that in SPDC process in NLCs a quantum signal usually has a power in order of pW or smaller which means that it is very low-power compared to the classical light signal which may be in order of $ \mu $W or nW or mW. Thus, one can urge that the damage or destructive effects in case of quantum measurement are definitely very smaller than the case of classical light with very higher power. Therefore, a quantum-based measurement might be seen as a non-invasive measurement technique which is so important especially in biological samples. Nevertheless, it definitely needs to be proven but we leave it as a novel research for the next future works.

\end{itemize}

\section{Summary, Conclusion remarks and Outlooks \label{summary}}
We have shown that the CC rate measurement of the generated frequency-entangled biphotons at NIR wavelength $ \rm 810nm $ which pass through the solutions, DNA and MB, and TFs enables us to high precision quantum transmittometry with 4-digit accuracy for coincidence time-window 7.1ns, while the SC measurement as the classical measurement leads to 3-digit accuracy.
Furthermore, for very dilute solutions in order of $ 0.01 \rm ng/\mu l $ or lower, the SC measurement of transmittance never gives reliable answers, while the CC measurement leads to highly reliable measurement of transmittance and distinguishability between the very diluted solutions.
Also, by obtaining the transmittance, one can calculate the refractive index by considering the proper model for the transmittance vs refractive index and parameters sample yielding to 3-digit accuracy.
In contrast to the quantum spectroscopy, the method needs no monochromators or narrow-band filters for the samples with absorption frequency far from signal-photon wavelength 810nm.
Moreover, by choosing a convenient model for concentration vs refractive index or transmittance, one may estimate and obtain the concentration of solutions with $ \rm 0.1pg/\mu l$ precision.

Interestingly, it seems that the method has potential to be improved. If one can use the coincidence counter with more narrower time-window, for example in order of ps instead of current ns, using the deep learning methods for noise cancellation, and using a source with higher rate such as PPKTP Sagnac-based source (see Ref.~\cite{pirandola2015Communication} and references therein) in which $  \Delta N/\bar N $ is usually in order of $ 10^{-5} $, one may expect to measure the transmittance based on the CC measurement with at least 5-digit, which may yield to very more accurate refractive index or concentration.

Finally as outlooks, the method has potential to open a new platform to high-precision quantum transmittometry of different types of samples. Also, we are hoping it opens a new pave in the next future to \textbf{\textit{non-invasive} }quantum diagnosis of cancer tissues like brain tissues or rat, Retina, Liver tissues and Stem Cells as an application of quantum measurement based on entangled photons in the context of quantum biology.

\section*{AUTHOR CONTRIBUTIONS}
A.M.F. proposed the primary idea. A.M.F and S.A.M. developed the idea of using DNA and MB solutions, respectively, and conceived the experiment, built the experimental setup, experimental measurements and analyzed the data. A.M.F. and S.A.M. performed the theoretical calculation and numerical analysis (via MATLAB software), respectively. All authors contributed to prepare the manuscript. A.M.F. wrote the manuscript, revised and answered to the referees' comments during the process.

\section*{Acknowledgments}
We express our gratitude to ICQTs.
We also express our gratitude to Dr. M. Abbasi who performed the graphical works related to DNA/Methylene via AVOGADRO software. We also thank Dr. M. Akbari because of his useful comments on quantum spectroscopy. Furthermore, we express our gratitude to Dr. Neda Shirin, manager of Neda Chemistry Ltd., and also to Mr. F. Alidoust and Dr. P. Zardari for preparing DNA and Methylene solution samples, respectively, and their discussions on biological/chemical properties of these solutions. Finally, we thank Prof. A. Rostami, Prof. M. H. Naderi and Prof. R. Roknizadeh because of their useful comments and discussions. We also thank the Dr. N. S. Vayaghan  who is also the supervisor of the quantum optics Lab, and currently the equipment is at his disposal. Finally, we thank the Dr. J. Sabet and Dr. M. Aaram.

\section*{Disclosures}
The authors declare no conflicts of interest.

redpajama_set_name: RedPajamaArXiv


Portable oxygen concentrators have revolutionized the care of oxygen-dependent patients. With portable oxygen concentrators, patients are no longer bound to use their devices at home and can travel with their devices and live a more independent lifestyle.
Patients using portable oxygen concentrators enjoy the benefits of increased ambulation, which also contributes to their mental and physical well-being.
Most patients would find it challenging to choose the best portable oxygen concentrator on the market. This is because getting an oxygen concentrator is not just about selecting the best device. Rather, it is about getting a product that fits the patient's health issue or condition.
There are two types of portable oxygen concentrators: Continuous flow and pulse dose (otherwise known as intermittent flow) oxygen concentrators.
These are the most common type of portable concentrators. These units provide a pulse of oxygen every time the user inhales.
Therefore a pulse flow portable oxygen concentrator only produces enough oxygen required to meet the user's needs and can deliver between 450 to 1250 milliters per minute of oxygen in short pulses.
In general, a pulse dose device is usually recommended for patients with low oxygen needs, i.e., up to two liters of oxygen per minute.
These devices are mostly used during the day when patients are awake and active. Although some people sleep with a pulse flow device, most do not. If you plan to sleep with one, it is best you consult your doctor first so that they can determine whether this is good for you.
Also, note that plus flow devices won't work with a continuous positive airway pressure (CPAP) or bilevel positive airway pressure machine (BiPAP).
These units are designed to provide oxygen continuously, regardless of the user's breathing pattern. Continuous flow units can deliver up to three liters of oxygen per minute. These devices work with CPAP and BiPAP and can be used 24 hours/7 days.
With the wide range of models available, it is no surprise that many patients do not know how to select an appropriate device. If this is you, the factors outlined below can help you narrow the search.
Your doctor will determine whether you need supplemental oxygen based on the results of a series of tests. They will determine the oxygen flow rate. Generally, any person who is prescribed more than two to three liters per minute is said to have a higher liter flow.
Note that although the setting on pulse oxygen concentrators reaches six, this is not synonymous to six liters per minute continuous flow. Some higher capacity devices can deliver up to 10 liters per minute.
If you do not require a high oxygen flow rate, you should opt for a smaller and less powerful device that can deliver one to five liters of oxygen per minute. This is where you should consider a model that will provide the ideal range of oxygen delivery to meet your needs and care.
Besides the size and weight, another factor to consider is the battery life of the device. Most portable oxygen concentrators use one battery that can last two and a half hours. In many cases, however, you can add a second battery.
Think of your daily routines, and how adding this device might alter them, if at all. So, when choosing a portable oxygen concentrator, think of your daily activities and how the use of the device might affect them.
When purchasing a portable oxygen concentrator, you should select a device that you can conveniently carry around. These devices come in a wide range of sizes and weights, so you have the option of choosing one that meets your needs.
Continuous flow oxygen concentrators are generally less portable than pulse dose units, with some weighing up to 18 pounds (excluding the weight of accessories). This is enough to warrant that you use a cart to pull the oxygen device.
Portable oxygen concentrators are economically priced compared to previous years. The latest offerings on the market are priced between $1499 and $3500.
Used devices cost anywhere between $800 and $2000 depending on the brand and model. Besides the initial cost of the device, users will have to spend on replacement batteries.
Budget is also important when making a purchasing decision because you should ensure the unit you purchase meets your oxygen delivery requirements.
While your current oxygen requirement is an important factor, you might have to consider your future needs, especially if you have chronic or unstable oxygenation requirements.
You wouldn't want to purchase a device that has a maximum capacity of five liters per minute if you'll require more in the future.
Therefore, it is imperative that you consult your doctor so that you have a better idea of your current and future oxygen requirements before purchasing an oxygen concentrator.
The oxygen concentrators listed here were chosen based on their functionality. What you finally settle for will depend on your needs, as determined by your doctor, and what your insurance provider covers.
Inogen One G4 is one of the smallest, lightest and most versatile portable oxygen concentrators. The device runs very quietly, with a noise level of only 40 dB at flow setting 2. Therefore, the patient can feel comfortable using the device at night or during social gatherings.
This pulse dose concentrator has three oxygen flow settings, and it is very effective in patients who regularly follow a physical activity. It can meet the increased oxygen demands of the patient during exercise physical activity by releasing a quick bolus or pulse dosage size, with each inhalation.
Inogen One G4 can detect when the patient's respiration becomes shallower and react by delivering a wider bolus of oxygen to meet the patient's breathing pattern and needs.
With the Inogen One G4, patients have the option between a single battery or double battery. In any case, the G4 has an acceptable battery life average, implying that you can use it for longer periods than you can with several other models.
Additionally, at 2.8 pounds, it is lighter than most portable oxygen concentrators and therefore more convenient to carry around.
This powerful and efficient pulse dose device is a good fit for patients who require oxygenation on a 24-hour basis. The device comes with integrated batteries and power cords.
Like the G4, Inogen One G3 can detect changes in the patient's breathing pattern and respond accordingly to match the patient's natural breathing pattern.
This is the best continuous flow device, although it has pretty much similar features to that of other portable oxygen concentrators. What makes it stand out from the rest is that it is equipped with DNA Technology.
With this technology, the Oxlife Independence sends information to your caregiver and oxygen provider through a secure network.
This smart continuous flow device sends data related to the use of your device, i.e., the frequency of use, oxygen setting, and respiratory rate. It can detect any issues and transmit them to your provider so they can fix the issues you might be facing as soon as possible.
Additionally, the DNA Technology makes the Oxlife Independence one of the most reliable oxygen concentrators in that it permits the device to learn and react to your usage patterns and environmental conditions.
Your carer can use these data to determine whether therapy is effective and whether there's any need to make changes to your treatment plan.
is very versatile and offers both continuous and pulse flow oxygen delivery, implying that it can meet the needs of most patients all year round. It can work with CPAP and BiPAP devices so you can use it during bedtime as needed.
You have the option of using one or two batteries at a time. Since this unit has a battery rating for pulse flow settings and another for continuous flow settings. The battery will run down faster when you use the device on continuous flow because the compressor and motor will be working continuously.
However, among other oxygen concentrators, the Oxlife Independence has one of the best battery life.
At 16 pounds, Oxlife is quite bulky. However, it is designed such that it can fit snuggly into tight spaces such as beneath a plane seat. Additionally, it has a foldable handle, which makes storage easier.
The Respironics SimplyGo is a reliable, easy-to-carry device that can provide both continuous flow and pulse dose therapy. In fact, it is the smallest portable oxygen concentrator weighing less than 10 pounds capable of working as a continuous flow and pulse dose concentrator.
SimplyGo was designed to provide optimal oxygen therapy to patients at all times of the day, during physical activity and social outings or while traveling.
When the user sets the device to Sleep Mode, it will detect the initiation phase of a breath–one of the four phases of a mechanical breath–it will release a pulse dosage of oxygen based on the setting.
In Sleep Mode, the Respironics SimplyGo is very sensitive and will detect changes in the patient's breathing pattern. In the case where it doesn't detect the patient's breath, the device switches to continuous flow mode to ensure the patient gets the necessary oxygen.
The device comes with a fashionable carry bag, rechargeable battery, cart, power cords, accessory case, and an instruction manual.
You're going to need a carry bag to go with your portable oxygen concentrator. Besides, the bag will also serve to store other accessories and your personal belongings.
These accessory bags come in various forms and styles. Most manufacturers offer users the option of choosing either a backpack or shoulder bag. It is important that you choose what you'll be comfortable carrying around.
When looking for a bag, there are a few things that you should consider.
Is your portable oxygen concentrator heavy, i.e., heavier than 15 pounds? If yes, you would need a mobile cart. Some designs come with a mobile cart. These concentrators are pretty bulky and are therefore not practical to carry in a bag.
Would you prefer to carry your portable oxygen concentrator on your back, hang it over your shoulder, or carry it across your chest? Whatever your choice, you check to make sure that your preferred option is available for your model.
What type of activities will you undertake? If you'll be undertaking activities such as bicycling, you'll need a backpack because a shoulder bag would get in the way or make you feel uncomfortable.
Inogen One G4 Carry Bag provides a protective cover to Inogen G4 Oxygen Concentrator. The stretchable fabric at the base of the bag is expandable to allow for use with a single or double battery. There is a slim open pocket inside the bag to allow for minimal storage of items such as ID cards and currency.Note: Image is shown with Concentrator which is sold separately.
Inogen One G3 Carry Bag provides a protective cover with a handle and adjustable shoulder strap to enable you to carry the Inogen One G3 Portable Oxygen Concentrator System (code IS-300-NA). No cart required.
Inogen One G3 Backpack is the perfect addition to the active oxygen user. It features a mesh shell with vents to ensure the G3 will not overheat. There are specially designed openings located on the top of the backpack that will allow the user to connect AC/DC power cords or cannulas without taking off the backpack.
Respironics SimplyGo Carrying Case is the carrying case for SimplyGo Oxygen Concentrator to be either carried over the shoulder or pulled on a cart.
Respironics Backpack For SimplyGo Mini Portable Oxygen Concentrator is designed as an alternative carrying case for the SimplyGo Mini Portable Oxygen Concentrator. It fits both standard and extended battery oxygen concentrators. This backpack features a main compartment for carrying the SimplyGo Mini concentrator and a zippered pocket for paperwork and accessories.
Invacare Accessory Bag is to be used with XPO2 Portable Oxygen Concentrator. It features convenient top handle and can hold AC and DC adapters and al batteries.
Invacare Platinum Mobile Oxygen Concentrator Carrying Bag for the Invacare Platinum Mobile Oxygen Concentrator can convert to messenger, handbag, or backpack style carrying while on the go.
Precision Medical EasyPulse Portable Oxygen Concentrator Carry Bag is intended to make the POC easier to transport, prevent movement due to vibration and protect the device from minor mishaps. The POC can be operated in an upright position with the carry bag and the POC can be operated lying on its back only while in the carry bag.
GCE Zen-O Carry Bag for Zen-O Portable Oxygen Concentrator is the accessory bag for Zen-O Oxygen Concentrator.
Although this post describes the best portable oxygen concentrators, your decision to purchase an oxygen concentrator should be driven by your doctor's advice. Because oxygen therapy is a prescription, it is imperative that you follow the directions set out by your doctor.
Your doctor or respiratory specialist will determine how often and when you'll need oxygen therapy, the ideal flow rate, and how long you need it every day. You can then use this information to help you select a concentrator that will best suit your needs.
If you have used any of these devices, we would be glad to hear about your experience in the comment section below. To find out about other devices that can help you do everyday tasks and activities more easily, follow Healthy Buddys on Facebook.


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About Ridout Lumber
At Ridout, we have achieved a half-century of quality service to the residents of Arkansas and Missouri. If you haven't experienced the Ridout difference firsthand, just ask a friend or neighbor about our customer-first approach. We've been fortunate to stay in business for decades by providing the best prices, an extensive inventory with materials made to last along with in-store experts waiting to answer all of your questions and concerns.
With the ongoing growth and success at Ridout, it became time to merge resources and knowledge with US LBM Holdings, to better serve our customers. Now, the same family-owned values and approach from founder Homer Ridout, which have sustained Ridout since 1971, have the support and backing of over 7,000 associates, working to provide you with the optimal:
Design and Take Off
Flooring, Cabinets, Doors and Windows (With installed sales available)
Rentals (At Select Locations)
Construction Materials and Tools
Superior Hardware
Electrical, Plumbing, Roofing, Sidings, Lumber, Paint and More
The Ridout philosophy remains the same: to sell the highest-quality building materials at a competitive price while providing the best service in the industry. Without question or compromise. But don't take our word for it, start shopping now or find a location near you and see for yourself.
We are involved with many organizations for people in need. Check out the links below to learn more about them, and how you too, can invest in these organizations.
History of the Ridout Companies
The Ridout Companies have seen continued growth based on the ideals on which Homer Ridout started the business in 1971: "Our goal is to sell the highest quality materials for a competitive price while providing the best service in the industry."
Ridout was started in 1971 by Homer L. Ridout and his son Wayne Ridout. Many members of the Ridout family worked in the business over the years, including Wayne's wife, Robbye Ridout, son, Ross Ridout, and two daughters, Kristen Ridout Smith and Kari Ridout Rockwell. All of these family members were active in the business at the time of the acquisition by US LBM in 2017, with Ross Ridout staying on as President through 2021.
Ridout Lumber Company was Arkansas' largest family-owned lumber company chain and a top 20 lumberyard in the country in 2017 when it was acquired by US LBM. US LBM is one of the largest building material distributors in the United States via its network of leading specialty dealers and building supply companies. US LBM implements the philosophy of local autonomy and leadership to capitalize on the premier reputation of its operating companies and local customer relationships. For this reason, the Ridout companies still operate under the Ridout name, with Brad Cunningham being named President in January 2022.
There are 11 retail locations including 10 Ridout Lumber Companies and a Commercial Division in Little Rock which sells drywall, metal framing, and acoustical ceilings. All locations are in Arkansas except for one Ridout Lumber Company in Joplin, Missouri.
In addition to the 11 retail locations, the Ridout Companies also operate Arkansas Wholesale Lumber Company, which is a fully functional wholesale lumber distributor, serving as the buying company for all the Ridout Lumber Company locations and many independent dealers across the state.
Ridout also operates Ridout Door Company in Searcy. Through this facility, the largest door assembly plant in Arkansas, each Ridout location is supplied with a full line of interior and exterior doors in materials including wood, steel, and fiberglass.
The corporate offices for the Ridout Companies and Arkansas Wholesale are located in Searcy, Arkansas.
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While the off-brand shoes cost a fraction of the price of the top name brands, you shouldn't have to settle for inferior shoes just to save money. Shopping at thredUP gives you access to the brands you love at affordable prices. Whether you're a big fan of Nike, Stride Rite and Adidas or you want some cute kicks from The Children's Place, Land's End, or Gymboree, you can find boys' sneakers on our site that won't break the bank.
We're constantly updating our inventory of boys' gym shoes and casual shoes, so make sure you check back when your kiddo outgrows his pair. Little ones are notorious for only wearing shoes for a few months before their feet get too big, so why bother paying those expensive name-brand prices? Instead, just browse the latest additions at thredUP and you'll have a fresh new selection of sneaker styles from which to choose every time he needs the next size up.
Half the fun of picking out kids' shoes is that you have so many fun colors and styles at your disposal. Just like when you shop for boys' dress shoes, boys' boots, or boys' sandals, you'll be able to find cute looks when you browse our collection of boys' sneakers. It's easy to find a neutral color like black, white, or navy to go with everything, but you'll also discover funky colors and cool patterns that are sure to make him feel special. Try Nike sneakers or Adidas sneakers for bright neon colors and bold tones, and chuck out Sanuk or Hanna Andersson shoes if you like cute patterns.
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It was a so-called "model camp" that the Nazis used to show the Red Cross that they were treating prisoners well. It was also a camp in which musicians, artists, and theater people were held to stage shows for visiting officials. It was in that camp where a cabaret, called The Last Cyclist, was created by an artist named Karl Svenk in 1944.
Lake Effect's Bonnie North with playwright Naomi Patz, director Marc Boergers and dramaturg Dan Haumschild.
The Last Cyclist will be at Cardinal Stritch University's Nancy Kendall Mainstage Theater in the Joan Steele Stein Center for Communication Studies/Fine Arts building on the Cardinal Stritch University campus April 5-14.


The management of Lotus Laboratory Services (M) Sdn.Bhd is committed to constantly ensure the	available of latest analytical technique and equipment, and to provide the most accurate result	for our clients. It is also the objective of the company to ensure speedy delivery of reliable	results and high quality products.
It is the policy of the company to self guard the interest of the clients. Hence, you can be assure	that when your sample reaches our laboratory, all information shall be strictly confident and	shall not be reveal to any third party without your prior approval.


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Rock the Night For Charity With Boogie & the Yo-Yoz at the Lake
Lac du Flambeau, Wis. – Enjoy a night rocking and dancing to your favorite hits with Boogie & the Yo-Yoz at Lake of the Torches on Saturday, March 16, at Lake of the Torches Resort Casino.
One of Wisconsin's hottest bands, Boogie & the Yo-Yoz will perform the favorite pop, rock and country songs of today and the past three decades. The band includes a three-piece horn section for an amazing musical experience. Must be 18 to enter showroom.
They will play from 7PM – 10PM in the Hall of Nations convention center. Admission is $5 and proceeds will be donated to a local branch of The Salvation Army which provides emergency assistance and other basic services to families and residents throughout the Northwoods.
"Cure your cabin fever and hit the dance floor with this extraordinary band performing your favorite tunes. Join us for a wonderful night to help out the important work of The Salvation Army here in northern Wisconsin," said Lake of the Torches Director of Marketing Leana Schlecht.
Situated on the shores of Pokegama Lake and nestled in Wisconsin's Northwoods, the Lake of the Torches Resort Casino has a feel of a classic Northern retreat and reflects its Ojibwe culture and heritage. The casino has over 800 slot machines, Blackjack, Craps, a high-stakes Bingo Hall, Woody's Bar and Grill and the Eagle's Nest Restaurant. The hotel has 101 well-appointed rooms, the Dancing Waters Lounge and the Woodland Oasis pool area. The 8,500 square-foot Convention Center with the Hall of Nations offers an outstanding venue for entertainment, receptions, trade shows, meetings, presentations and seminars. It is proudly owned and operated by the Lac du Flambeau Band of Lake Superior Chippewa Indians.
Information on upcoming events and promotions at Lake of the Torches is available at www.lakeofthetorches.com.


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2022 Night Sky Almanac: A Month-By-Month Guide to North America's Skies from the Royal Astronomical Society of Canada (Paperback)
A portable guidebook for enjoying the night sky in 2022.
2022 Night Sky Almanac is the ideal resource for both novice and experienced sky watchers in the United States and Canada, with all of the advice, information and data that enthusiasts need to understand and enjoy the wonders of the night sky.
This in-depth guide first introduces readers to the objects in the sky -- from stars, to comets, to globular clusters -- and then takes them through the cosmic events to look out for each month in 2022, with sky maps, moon phase charts and info about the planets. The book also features:
Methods for using your hands to measure angles in the sky Information about binoculars and telescopes A glossary of terms A list of helpful resources And much, much more
2022 Night Sky Almanac is both a comprehensive introduction to astronomy and a quick reference book for more experienced sky watchers who don't want to miss a thing. Its compact size means it's perfect for taking on an astro-vacation or simply sky viewing in the backyard.
The Royal Astronomical Society of Canada (RASC) was founded ad hoc in 1868 and incorporated in 1890 with a dual membership of professionals and amateurs. It has 29 Canadian chapters and over 5,000 members. The Journal of The Royal Astronomical Society of Canada is entering its 115th year of publication, and the RASC also produces a number of other publications and guidebooks.
Nicole Mortillaro is an avid amateur astronomer, author, editor, Senior Science Reporter for CBC News and the editor-in-chief of the Journal of The Royal Astronomical Society of Canada. She is the author of Saturn, and lives in Toronto, Canada.
Publisher: Firefly Books
Space Science - Astronomy
Yearbooks & Annuals