Corzine: Start early, stay with it, and keep talking to the public about what the problems are. Make it clear that you're addressing these problems, but also make it clear that the challenges didn't get created in a year or two or even a single term, it's almost the exact words that President-elect Obama said on the night of his election, that it will take time for any administration, any leader to move a country that is in the kind of position that we're in as a nation. And I can say that just as equally about where we are as a state. How you restructure, reform and get into a position of stability for the public is going to take time and it's going to come with a lot of hard choices. And so, people need to give the President-elect the opportunity to see these things work. It's now a tired phrase but there are no silver bullets to this. It is a lot of hard work and it takes time.
Jon Corzine says not all economic recovery is top down.


text:
Kirk Cousins says penalty on Clay Matthews was a 'generous' call
It was the difference between the Vikes tying and losing.
Joe Nelson
Fun fact: Daniel Carlson would've missed just one field goal in Sunday's tie between the Vikings and Packers had the officials not flagged linebacker Clay Matthews for roughing the passer late in the fourth quarter.
Matthews dumped quarterback Kirk Cousins on a pass that was intercepted by the Packers. Had the flag not been thrown, the Packers would've taken a couple of knees and won the game 29-21. But the flag gave the Vikings life and Cousins wound up hitting Adam Thielen for an incredible touchdown with 31 seconds left in the fourth quarter.
Interestingly, referee Tony Corrente made the call and later explained to ESPN that Matthews' flag didn't fall under the new rule that keeps players from driving quarterbacks into the ground with their full body weight. Instead, Corrente through the flag because Matthews picked Cousins up and drove him into the ground.
But even Cousins said the call was a bit "generous."
"I haven't seen it. I'm sure it was probably a generous call, and two or three years ago, it probably doesn't get flagged," Cousins said in Peter King's Football Morning in America. "But that's one of those plays the Packers felt made a huge difference in the game, and there are some we felt made a huge difference in the game. Both sides can point to several plays I'm sure."
Watching the replay back, one might argue that Cousins left the ground with both feet when he let the pass fly, making it look like Matthews picked him up off the ground.
Regardless, pretty much everyone on the planet agrees that it was a questionable call, and likely the difference between the Vikings leaving Lambeau with a tie rather than a loss.
Clay MatthewsKirk CousinsGreen Bay PackersMinnesota Vikings
Schefter says Vikings, Kirk Cousins will 'figure something out'
Should the Vikings restructure his contract to delay the inevitable 2-3 years?
National columnist calls Kirk Cousins a flop, says he's 'astonishingly meh'
What's up with the attacks on Olive Garden's quality?
NFL insider: 'A Kirk Cousins trade would not surprise me'
Jason La Canfora of CBS Sports has made some big Vikings reports this week.
Cousins trying to trademark catchphrase 'You Vike that!'
It's a play on the "You like that!" phrase he made famous in Washington.
Kirk Cousins dominates on his first drive with the Vikings
The Vikings beat the Broncos 42-28 in their preseason opener.
Vikings GM raves about Cousins, says he's great 'when the odds are shifted in his favor'
Kwesi Adofo-Mensah also talked about Cousins needing to find the balance between Superman and Clark Kent.
Kirk Cousins has a new podcast to get to know him
Episode one is pretty entertaining.

redpajama_set_name: RedPajamaCommonCrawl


text:
House of Saint Peter (Capernaum)
House of saint Peter (Latin: "Domus Ecclesia") or referes to a first century structure discovered underneath a fourth-fifth century church remains. Facing the lake shore, the residence formed the southeastern extremity of a large inhabited area. The compound had its main door on its eastern side, opening onto an open. The door jamb preserves traces of the door leaves which were bolted from the inside in the evening when people went to bed.
Home > Middle East > Israel/Palestine > Capernaum > House of Saint Peter
Although slightly larger than most, the house of Saint Peter was simple, with coarse walls and a roof of earth and straw. Like most early Roman-period houses, it consisted of a few small rooms clustered around two open courtyards. Despite later proving to be one of the most exciting Biblical archaeology discoveries, the house appeared quite ordinary. A fish-market and frontier post beside the Sea of Galilee, Capernaum became Jesus' home town and the scene of his activities.
The rectangular remains of the old black basalt stone walls, torn down during the construction of the octagonal church in the fifth century. Italian excavators working in Capernaum may have actually uncovered the remnants of the humble house of Peter that Jesus called home while in Capernaum. It is considered "the first church in the world" and believed it could be the place where the house of the Apostle Peter was.
The plastered floor of the inner room, or the large room, later Domus Ecclesia. In the 4th century, the room was enlarged and a central arch was added (illustration), the supporting ends of which can still be seen. The room was now the focal center of a house-church, perhaps the one built by Joseph. By 450 CE - to judge from "the hundreds of dishes stamped on the bottom with crosses" that were also found all over the site.
Mosaic lacerto. The Byzantine church dedicated to Saint Peter was paved with refined mosaics like this one with peacock (reconstruction) symbolizing the resurrection in the remains of the fourth and fifth century church of Saint Peter in Capernaum. The remains of Saint Peter's house in Capernaum were revealed when archaeologists decided to remove these mosaics to study the previous layers.
Floor plan of the structure dubbed as the House of Saint Peter (illustration) in Capernaum. Buried beneath the remains of an octagonal Byzantine martyrium church, excavators found the ruins of a rather mundane dwelling dating to the first century BCE. The "large room- later venerated room", stands out from as early as 50 CE, its floor, walls, and ceiling were plastered, a feature that does not appear anywhere else in the village. The ramins of the walls bear the graffiti; for example, "Lord Jesus Christ help your servant...".
Coin of Caracalla (215-217 CE) found in Peter's house. During excavations remains of items from different times were found, including this coin from early third century, fragments of Herodian era oil lamps, pottery shards fron first century and even a Hellenistic lamp.
Buried (dark blue outine) beneath the remains of an octagonal Byzantine martyrium church (light blue outine), Italian excavators found the ruins of a rather mundane dwelling dating to the first century BCE. Although slightly larger than most, the house was simple, with coarse walls and a roof of earth and straw. Like most early Roman-period houses, it consisted of a few small rooms clustered around two open courtyards.
The modern Saint Peter Memorial Church also called the Pilgrimage Church of St. Peter in Capernaum is a modern Catholic pilgrimage church built over the purported site of Saint Peter's House. The church is part of the Franciscan monastery in Capernaum. It is dedicated to St. Peter, which Catholics consider the first leader of the Church.
The Capernaum Synagogue is located north of the supposed House of Saint Peter. The synagogue appears to have been built around the 4th or 5th century. Beneath the foundation of this synagogue lies another foundation made of basalt, and Loffreda suggests that this is the foundation of a synagogue from the 1st century, perhaps the one mentioned in the Gospels (Loffreda, 1974).
Byzantine Era Saint Peter's Church
Pilgrimage Church of St. Peter in Capernaum


Welcome back to my fourth Christmas colour combo at The Colour Tree.
I hope the colour palette provides you with some inspiration for your Christmas projects!
Hi there and welcome to addINKtive designs. Over the weekend I made a few acceptance cards and this is my favourite one of the three. The gorgeous colour palette at Create with Connie and Mary provided me with a great starting point.
The arty process involved some heat embossing with white embossing powder, some masking, watercolouring a background with aquapainters, some collage stamping then adding the embellishments. It's not my usual style but I had a lot of fun putting this one together.
Welcome back to my third Christmas colour combo at The Colour Tree.
Welcome to addINKtive designs. I'm sharing another 'acceptance' card that I made today and decided to use the colour combo from Colour Me - Soft Suede, Crushed Curry and Cherry Cobbler.
They are gorgeous colours for 'Fall' but it just so happens that we are nearing the end of Spring down under, so I inked up my Swallowtail stamp and did some emboss resist using the Dots Decorative Mask.
1. Stamp Swallowtail with Versa Mark Ink onto Shimmery White Card.
2. Heat Emboss with White Embossing Powder.
3. Place Dots Decorative Mask over the image and use Sponge Daubers to apply the three different coloured inks.
4. Use an Aquapainter and watercolour the rest of the butterfly image using Crushed Curry Ink.
5. Add a sentiment using the Alphabet Rotary Stamp and secure the Blossom Accent with a Glue Dot.
Hi there. Here's a very clean and simple card; it's stamped in neutral colours on Kraft card stock using the beautiful stamps from Summer Silhouettes.
The sentiment is stamped using the Alphabet Rotary Stamp as I didn't have any 'acceptance' stamps - such a handy tool.
Welcome to addINKtive designs. I recently entered a watercolouring challenge at Just Us Girls and made a Small Flowerpot Easel Card for my mum's upcoming birthday. The card was inspired by a recent trip we had to the Tulip Farm at Table Cape. There were so many photos that I wanted to share on my blog that I decided to write another post.
This easel card is made with SU's Envelope Liners Framelits smallest die and the beautiful tulips stamp is from a retired set called, Blessed Easter.
I really appreciate the many crafters all over the globe that purchase my tutorials; the sales help to keep me in SU supplies so I can continue to create and share my ideas with you. My day job keeps me very busy and I have limited time available to hold classes or workshops. So ... thank you!
My mum enjoying the tulips at Table Cape, near Wynyard in Tasmania.
Another place ticked off my bucket list!
I love Spring in Tasmania. It sure is a beautiful part of the world.
It's Trend Week at Just Us Girls and it's all about using watercolouring on your card or project. What perfect timing! I recently purchased a retired stamp set called, Blessed Easter and it only just arrived in the mail on Friday. The tulips are perfect for watercolouring so I chose a variety of inks and used an Aqua Painter to colour the flowers.
Inspiration came from a recent trip to the Tulip Farm at Table Cape.
Welcome back to my second Christmas colour combo at The Colour Tree.
I hope the colour palette provides some inspiration for your Christmas projects!
Hi there. Yesterday I enjoyed some time in my craft room and was loving the idea of not having to think too hard about what I wanted to create; I decided that in order to get my mojo back, I would CASE (copy and share everything) a beautiful card that I spotted over at The Global Design Project. It's a real stunner designed by Steffi Helmschrott from Stempelwiese.
It's rare that I completely CASE a card right down to the layout and colour scheme but Steffi's card was sheer perfection in my book. Not only did I end up with a very pretty card, my mojo did return and for that I am extremely grateful. I now have a list of supplies I need for another SU order, my Swallowtail stamp got inked up for the second time, I decided that I really do enjoy heat embossing and watercolouring the background and have now declared Shimmer White as my favourite card stock of all time! It also did take my mind off the fact that I was missing being in Melbourne for On Stage with my stamping buddies (sniff).
There's a few subtle changes that I made because I didn't have all the same supplies as Steffi and I also decided to emboss the vellum punched flowers and use Shimmer White Card Stock instead of watercolour paper. Thanks, Steffi for your inspiration; I think I might need to make some more in different colours!
Be sure to come back in a few hours (7 pm AEST) to see my second Christmas Colour Combo for The Colour Tree.
Hi there. It's been a while since I have had the opportunity to make some cards as life has been a little hectic lately. I needed a sympathy card for a friend of mine who recently lost her mum and decided to CASE a design that I discovered through Pinterest.
You can view Brandy's Cards Tutorial on You Tube - Butterfly Basics, 10 cards in 20 minutes.
I love Brandy's design but made a few subtle changes and chose one of my Colour Tree colour combinations.
The next card is a CASE of the above using a different stamp set, Awesomely Artistic and another one of my Colour Tree colour palettes.


text:
Cinema Spotlight
Movie Reviews and More
REVIEW: "Split"
By jasonbleau March 1, 2017 December 31, 2017
1 Comment on REVIEW: "Split"
While he has certainly seen his share of critical failures, Director M. Night Shyamalan has seen somewhat of a resurgence in recent years with the under appreciated found-footage film "The Visit" shocking moviegoers in 2016 and "Devil", which he wrote and produced, making its mark on modern horror in 2010. However many have waited for his true comeback film to arrive and it appears we finally have it in the form of the psychological horror thriller "Split".
Focusing on a trio of young women taken captive by a man with 23 personalities living in his brain, "Split" features a very impressive performance by James McAvoy ("X-Men: Apocalypse", "Wanted") who steps into the shoes of the film's antagonist, Kevin, and his many different identities. Casey, played by Anya Taylor-Joy ("Morgan", "The Witch") who has found an early niche for her career as a horror actress, is among the three girls abducted and works to formulate an escape with her fellow captives, meeting several of Kevin's personalities along the way.
The three women meet neat freak Dennis, who kidnapped the trio, proper woman Patricia, and 9-year-old personality Hedwig who has the ability to force personalities into and out of "the light" to take control of Kevin's body. The audience also learns about Kevin's condition through his meetings with Dr. Karen Fletcher, played by Betty Buckley ("The Happening") and as the film unfolds the pieces begin to come together as to the motives of the three personalities for performing the kidnapping and their plan for Kevin's future.
In true Shyamalan fashion the film has it's twists and turns. The shocking reveal of Casey's past is harsh enough but once we find out the motives of Dennis, Patricia, and Hedwig the film takes a darker turn that puts the girls, and potentially the world, in danger as Kevin's other personalities begin to lose control. The film also tackles some deep, and in ways disturbing, themes as Kevin's darker personalities make implications about the human condition and imperfection. McAvoy does an outstanding job switching seamlessly between personalities while Anya Taylor-Joy proves to be a standout, continuing to show her growth as an actress by guiding her character through fear, setbacks, and a life-or-death battle of wits.
Of course the film concludes on an amazingly well kept secret, which many have probably learned by this point through word of mouth. For those who are fans of Shyamalan's previous work, the concluding scene will truly surprise you and hints at a sequel while showing the viewer the world that was so small inside Kevin's hideout is actually much bigger and the threat is more real than the film implied at the beginning.
While "Split" may have its naysayers due to the somewhat convoluted nature of its main character's condition and its more negative and fear driven approach to the concept of dissociative identity disorder, it is a very solid film. With great casting, an impressive series of twists, and even a few character-developing scenes that actually feel significant to the plot, "Split" it an entertaining thrill ride that brings out the best Shyamalan, and the actors involved, have to offer. Here's hoping this film solidifies a return to form for the always divisive king of plot twists.
Published by jasonbleau
View all posts by jasonbleau
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text:
The **LinkTo** plugin for Grav is an extension to twig. This extension contains a filter and a function used to convert a given set of variables and options to some html link tags.

## Usage

### Create a link with a page object

If nothing else than a page object is passed, the url and the content will default to it's *url* and *menu* properties.

```twig
{{ pages.find('/home')|link_to }}
{# or #}
{{ link_to(pages.find('/home')) }}

{# outputs '<a href="/">Home</a>' #}
```

### Adding some options

It is possible to configure the link that will be displayed by passing an array of [options](#options) to the filter.

```twig
{{ pages.find('/home')|link_to({'class': 'some-class'}) }}
{# or #}
{{ link_to(pages.find('/home'), {'class': 'some-class'}) }}

{# outputs '<a href="/" class="some-class">Home</a>' #}
```

### Using a string as content

A string can be passed to the link_to filter. This will be used as the link's body. If no [options](#options) are passed to the link, the link will have no href and can be used as a [placeholder hyperlink](https://www.w3.org/TR/html-markup/a.html#placeholder-hyperlink)

```twig
{{ 'Some External Page'|link_to({'class': 'some-class', href="http://example.com/"}) }}
{# or #}
{{ link_to('Some External Page', {'class': 'some-class', href="http://example.com/"}) }}

{# outputs '<a href="http://example.com/" class="some-class">Some External Page</a>' #}
```

### Creating a link from array

It is also possible to create a link only from an array of option. If a second array of [options](#options) is passed, the [options](#options) contained in this second array will override [options](#options) from the first array.

```twig
{{ {'page': pages.find('/home'), 'class': 'some-class'}|link_to }}
{# or #}
{{ link_to({'page': pages.find('/home'), 'class': 'some-class'}) }}

{# outputs '<a href="/" class="some-class">Home</a>' #}
```

### Using a block as content

The [filter](http://twig.sensiolabs.org/doc/tags/filter.html) section can be used to pass a block of content as the body of the link.

```twig
{% filter link_to({'class': 'some-class', href="http://example.com/image.jpg"}) %}
  <img src="http://example.com/thumbnail.jpg" width="100" height="100" alt="Sample image">
{% endfilter %}

{# outputs '<a href="http://example.com/image.jpg" class="some-class"><img src="http://example.com/img.jpg" width="100" height="100" alt="Sample image"></a>' #}
```

## Options

Options are used to configure the html link tag that will be outputted.

Valid options are:
* **page**: Page object passed to set default link and content.
* **content**: Html string that will be inserted as content into the link. When specified, it will overwrite any content retrieved from a page object.

Any other attributes passed to the option array will be added to the html link tag.

```twig
{{ {'href': '/lorem-ipsum', 'data-lorem-ipsum': 'dolor-sit-amet', 'content': 'Lorem Ipsum'}|link_to }}

{# outputs '<a href="/lorem-ipsum" data-lorem-ipsum="dolor-sit-amet">Lorem Ipsum</a>' #}
```

redpajama_set_name: RedPajamaGithub


text:
Phase I and pharmacokinetic study of tirapazamine (SR 4233) administered every three weeks
Suresh Senan*, Roy Rampling, Martin A. Graham, Peter Wilson, Hernani Robin, Nils Eckardt, Nora Lawson, Alex McDonald, Reinhard Von Roemeling, Paul Workman, Stanley B. Kaye
Tirapazamine (SR 4233; 3-amino-1,2,4-benzotriazine-1,4-di-N-oxide) is a bioreductive agent exhibiting up to 200 x greater toxicity for hypoxic cells as compared to oxygenated cells. In murine studies, a selective increase in tumor kill was observed when tirapazamine was coadministered with other agents, notably cisplatin. A Phase I study of single-agent tirapazamine administered i.v. every 3 weeks was conducted to determine the toxicity of a schedule for use with systemic chemotherapy. A total of 28 patients were given 50 courses of tirapazamine at doses ranging from 36-450 mg/m2. No tumor responses were observed. Reversible deafness and tinnitus were dose-limiting, with ototoxicity observed in 1 of 6 patients treated at 330 mg/m2, 1 of 4 patients treated at 390 mg/m2, and 3 of 3 patients treated at 450 mg/m2. Muscle cramps, nausea, and vomiting were also observed. Pharmacokinetic studies revealed a greater than dose-proportional increase in the area under the plasma concentration x time curve (AUCs) of the two major metabolites. Patients who developed ototoxicity generally showed higher plasma AUC values for the parent drug and metabolites. The mean plasma tirapazamine AUC at 330 mg/m2 was 1026.5 μg/ml x min (range 863.8-1252.3), but no pharmacokinetic data are available for the solitary patient who developed otoxicity at this dose level. These AUC values were in the (estimated) range required for therapeutic effect in murine studies. Ototoxicity was not observed when the AUC of tirapazamine was equal to or less than 1252 μg/ml x min. The dose of 330 mg/m2 was therefore chosen as an appropriate level for combination chemotherapy studies.
Senan, S., Rampling, R., Graham, M. A., Wilson, P., Robin, H., Eckardt, N., Lawson, N., McDonald, A., Von Roemeling, R., Workman, P., & Kaye, S. B. (1997). Phase I and pharmacokinetic study of tirapazamine (SR 4233) administered every three weeks. Clinical Cancer Research, 3(1), 31-38.
Senan, Suresh ; Rampling, Roy ; Graham, Martin A. et al. / Phase I and pharmacokinetic study of tirapazamine (SR 4233) administered every three weeks. In: Clinical Cancer Research. 1997 ; Vol. 3, No. 1. pp. 31-38.
@article{8510f1bf72a1433583d419fbaa5184e3,
title = "Phase I and pharmacokinetic study of tirapazamine (SR 4233) administered every three weeks",
abstract = "Tirapazamine (SR 4233; 3-amino-1,2,4-benzotriazine-1,4-di-N-oxide) is a bioreductive agent exhibiting up to 200 x greater toxicity for hypoxic cells as compared to oxygenated cells. In murine studies, a selective increase in tumor kill was observed when tirapazamine was coadministered with other agents, notably cisplatin. A Phase I study of single-agent tirapazamine administered i.v. every 3 weeks was conducted to determine the toxicity of a schedule for use with systemic chemotherapy. A total of 28 patients were given 50 courses of tirapazamine at doses ranging from 36-450 mg/m2. No tumor responses were observed. Reversible deafness and tinnitus were dose-limiting, with ototoxicity observed in 1 of 6 patients treated at 330 mg/m2, 1 of 4 patients treated at 390 mg/m2, and 3 of 3 patients treated at 450 mg/m2. Muscle cramps, nausea, and vomiting were also observed. Pharmacokinetic studies revealed a greater than dose-proportional increase in the area under the plasma concentration x time curve (AUCs) of the two major metabolites. Patients who developed ototoxicity generally showed higher plasma AUC values for the parent drug and metabolites. The mean plasma tirapazamine AUC at 330 mg/m2 was 1026.5 μg/ml x min (range 863.8-1252.3), but no pharmacokinetic data are available for the solitary patient who developed otoxicity at this dose level. These AUC values were in the (estimated) range required for therapeutic effect in murine studies. Ototoxicity was not observed when the AUC of tirapazamine was equal to or less than 1252 μg/ml x min. The dose of 330 mg/m2 was therefore chosen as an appropriate level for combination chemotherapy studies.",
author = "Suresh Senan and Roy Rampling and Graham, {Martin A.} and Peter Wilson and Hernani Robin and Nils Eckardt and Nora Lawson and Alex McDonald and {Von Roemeling}, Reinhard and Paul Workman and Kaye, {Stanley B.}",
journal = "Clinical Cancer Research",
publisher = "American Association for Cancer Research Inc.",
Senan, S, Rampling, R, Graham, MA, Wilson, P, Robin, H, Eckardt, N, Lawson, N, McDonald, A, Von Roemeling, R, Workman, P & Kaye, SB 1997, 'Phase I and pharmacokinetic study of tirapazamine (SR 4233) administered every three weeks', Clinical Cancer Research, vol. 3, no. 1, pp. 31-38.
Phase I and pharmacokinetic study of tirapazamine (SR 4233) administered every three weeks. / Senan, Suresh; Rampling, Roy; Graham, Martin A. et al.
In: Clinical Cancer Research, Vol. 3, No. 1, 26.02.1997, p. 31-38.
T1 - Phase I and pharmacokinetic study of tirapazamine (SR 4233) administered every three weeks
AU - Senan, Suresh
AU - Rampling, Roy
AU - Graham, Martin A.
AU - Wilson, Peter
AU - Robin, Hernani
AU - Eckardt, Nils
AU - Lawson, Nora
AU - McDonald, Alex
AU - Von Roemeling, Reinhard
AU - Workman, Paul
AU - Kaye, Stanley B.
N2 - Tirapazamine (SR 4233; 3-amino-1,2,4-benzotriazine-1,4-di-N-oxide) is a bioreductive agent exhibiting up to 200 x greater toxicity for hypoxic cells as compared to oxygenated cells. In murine studies, a selective increase in tumor kill was observed when tirapazamine was coadministered with other agents, notably cisplatin. A Phase I study of single-agent tirapazamine administered i.v. every 3 weeks was conducted to determine the toxicity of a schedule for use with systemic chemotherapy. A total of 28 patients were given 50 courses of tirapazamine at doses ranging from 36-450 mg/m2. No tumor responses were observed. Reversible deafness and tinnitus were dose-limiting, with ototoxicity observed in 1 of 6 patients treated at 330 mg/m2, 1 of 4 patients treated at 390 mg/m2, and 3 of 3 patients treated at 450 mg/m2. Muscle cramps, nausea, and vomiting were also observed. Pharmacokinetic studies revealed a greater than dose-proportional increase in the area under the plasma concentration x time curve (AUCs) of the two major metabolites. Patients who developed ototoxicity generally showed higher plasma AUC values for the parent drug and metabolites. The mean plasma tirapazamine AUC at 330 mg/m2 was 1026.5 μg/ml x min (range 863.8-1252.3), but no pharmacokinetic data are available for the solitary patient who developed otoxicity at this dose level. These AUC values were in the (estimated) range required for therapeutic effect in murine studies. Ototoxicity was not observed when the AUC of tirapazamine was equal to or less than 1252 μg/ml x min. The dose of 330 mg/m2 was therefore chosen as an appropriate level for combination chemotherapy studies.
AB - Tirapazamine (SR 4233; 3-amino-1,2,4-benzotriazine-1,4-di-N-oxide) is a bioreductive agent exhibiting up to 200 x greater toxicity for hypoxic cells as compared to oxygenated cells. In murine studies, a selective increase in tumor kill was observed when tirapazamine was coadministered with other agents, notably cisplatin. A Phase I study of single-agent tirapazamine administered i.v. every 3 weeks was conducted to determine the toxicity of a schedule for use with systemic chemotherapy. A total of 28 patients were given 50 courses of tirapazamine at doses ranging from 36-450 mg/m2. No tumor responses were observed. Reversible deafness and tinnitus were dose-limiting, with ototoxicity observed in 1 of 6 patients treated at 330 mg/m2, 1 of 4 patients treated at 390 mg/m2, and 3 of 3 patients treated at 450 mg/m2. Muscle cramps, nausea, and vomiting were also observed. Pharmacokinetic studies revealed a greater than dose-proportional increase in the area under the plasma concentration x time curve (AUCs) of the two major metabolites. Patients who developed ototoxicity generally showed higher plasma AUC values for the parent drug and metabolites. The mean plasma tirapazamine AUC at 330 mg/m2 was 1026.5 μg/ml x min (range 863.8-1252.3), but no pharmacokinetic data are available for the solitary patient who developed otoxicity at this dose level. These AUC values were in the (estimated) range required for therapeutic effect in murine studies. Ototoxicity was not observed when the AUC of tirapazamine was equal to or less than 1252 μg/ml x min. The dose of 330 mg/m2 was therefore chosen as an appropriate level for combination chemotherapy studies.
JO - Clinical Cancer Research
JF - Clinical Cancer Research
Senan S, Rampling R, Graham MA, Wilson P, Robin H, Eckardt N et al. Phase I and pharmacokinetic study of tirapazamine (SR 4233) administered every three weeks. Clinical Cancer Research. 1997 Feb 26;3(1):31-38.


text:
Station Ebeltoft var en station i den danske by Ebeltoft. Stationen var tegnet af arkitekt Heinrich Wenck.

Det var endestation for Trustrup - Ebeltoft Jernbane, som i 1968 blev lukket. Selve stationen blev revet ned i 1970.

Nedlagte jernbanestationer i Danmark
Ebeltoft

redpajama_set_name: RedPajamaWikipedia


text:
Q: I need to add more and more  for an irrigation schedule, an idea? It is in javascript, and I use cloneNode(), the clone it's created but "time-picker" not work.
addSchedule() {
    var time_picker = document.getElementById("time");
    var clone = time_picker.cloneNode(true);
    document.getElementById("schedule").appendChild(clone);
}

redpajama_set_name: RedPajamaStackExchange


Cannabidiol or CBD is a promising phytocannabinoid found in industrial hemp. It has been recognized for its benefits on human and animal health and is capable of affecting nearly every biological process. CBD is non-psychoactive and non-toxic.
*The FDA has not evaluated these statements. This product is not intended to treat, cure, or diagnose any disease.
**If you have a medical condition or take pharmaceutical drugs, please consult a physician before use.
All CBD Oil sales are final. No return or exchanges. However, see shipping return policy if you ordered CBD oil online. On other hemp items, returns are accepted for in store credit if returned within 10 days of purchase with a receipt.
Yes, we can ship to all 50 states. However, we cannot ship CBD oil to any P.O. Box addresses.
Of course! Our friendly and knowledgeable customer services reps are available to answer your questions during store hours. Please feel free to email 502hemp@gmail.com or call our store at 502-654-7100.
Yes! These products are produced in a federally approved program authorized under Section 7606 of the 2014 Farm Bill. Kentucky Department of Agriculture has established this program, which allows for the production, manufacturing, and shipping of hemp products across state lines. Kentucky is one of a few states operating in compliance with the federal guidelines, which allows sales as part of market research.
Where are the CBD oil products produced?
All of the hemp is grown in Kentucky. Our manufacturer has growers in 23 counties throughout the commonwealth. All of their extracts are made in their manufacturing facility located in Louisville, KY. They formulate and package all of their products in house.
Can CBD oil be given to children?
Yes! These products are non-toxic and non-psychoactive. However, we only recommend vape products to people at least 18 years of age.
Will these products interact with any medications?
If someone is on medication, we recommend discussing these products with your doctor and/or pharmacist BEFORE consuming.
Read US Patent # 6,603,507. This is the patent owned by The United States Department of Health and Human Services. It lists the value as an anti-oxidant and a neuroprotectant. This information is available through the United States Patent and Trademark Office.
Can it ``Get you high``?
No! These products are derived from Industrial Hemp. Cannabidiol is non-psychoactive. There is not enough THC in the products necessary to induce a high. All retail products must be below the federal guidelines for THC, which is less than 0.3%.
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Looking for the best Dog Walking trails around Venice?
Find the top rated dog walking trails in Venice, whether you're looking for an easy short dog walking trail or a long dog walking trail, you'll find what you're looking for. Click on a dog walking trail below to find trail descriptions, trail maps, photos, and reviews.
Some shade on northern half depending on time of day. Phillips Park about mid island is a good place to park.
We rode from St James to the middle of Pine Island. The trail was just okay. Nice cement sidewalk along side the highway. Not a lot to see. However, beyond the trail in St James we had the best seafood gumbo ever at The Waterfront Inn Restaurant and the Key Lime Pie was to die for!!
Stop at the visitor center as you enter the island to get a map. Free parking and restrooms at the SCCF Park 1300 Periwinkle Way, about a mile from the visitor center. Trails are all in good condition and separated from traffic. There are much more than 24 miles if you do all the trails. The trail is busy along Periwinkle, but then it thins out and you can ride as fast as you want. Bikes can be rented in a number of locations so there are a lot of kids and inexperienced riders, but they usually stay on their side.
Nice trail! North of Tarpon Springs is a bit boring, but the entire trail is very well maintained!
This long concrete path links Bokeelia in the north, to St James City in the south of Pine Island.
Yes, it can be somewhat boring, due to lack of buffer landscaping and rest areas along the busy main road, Stringfellow. However, just off the path are some truly unique sights: such as the historically-significant Calusa homeland, Pineland (extinct indigenous peoples of southwest Florida), and beautiful conservation areas, like Galt Preserve.
Off-path side roads are flat, quiet and welcoming for bicyclists, especially beginning north of Harbor Drive-Pineland, keeping west and north. Don't be afraid to venture off the concrete, but bring plenty of drinking water and snacks.
Great photo opps: Bokeelia fishing pier, Pineland Marina pier, Calusa shell mounds, Randall Research Center.
Note: locally, bicyclists and residents have been asking Lee County, FL to reduce speed on Stringfellow to 45 mph. In the meantime, use caution when crossing Stringfellow Road.
Of interest to mountain bike and dirt riders: numerous dirt-sand roads crisscross Pine Island's many palm plantations. Some, but not all of these roads, are public property. Consult local maps for the best guides, available at Pine Island Library, Russell Road.


text:
E3 2016: 'Batman – The Telltale Series' – New Screens, Cast Details, Release Window
By Jamiex66 on June 13, 2016 • ( 2 Comments )
Telltale Games have released the first screenshots from the upcoming Batman – The Telltale Series, alongside revealing a star-studded cast of voice acting talent who will help bring Gotham's favourite characters to life.
The newly revealed screens showcase both Bruce Wayne and his alter-ego Batman, alongside Batman's on and off again ally, Catwoman. Batman – The Telltale Series is running on a new Telltale engine and it shows, with the beautiful visual style mimicking a comic book come to life.
"We've been hard at work at Telltale creating an all-new iteration of the iconic Batman story that puts players in the suit of billionaire Bruce Wayne, just as much as it will put them behind the mask, deciding how to carefully navigate a complex drama, rich with action, crime, corruption, and villainy lurking around every corner of Gotham City," said Kevin Bruner, Co-Founder and CEO of Telltale Games. "The complex life and fractured psyche of Bruce Wayne has lent itself to becoming a bold evolution of the signature 'Telltale' role-playing experience, and we couldn't be more excited as we prepare to debut the series to players across the world this summer."
Telltale has also revealed a the voice-cast that will be taking the role of iconic DC characters throughout the series. Well-known voice actor Troy Baker will be taking the role of Batman (interestingly he also has previously voiced Joker in Batman Arkham Origins), Travis Willingham as Harvey Dent/Two-Face, Erin Yvette as Vicki Vale, Enn Reital as Alfred Pennyworth, Murphy Guyer as Lieutenant James Gordon, Laura Baily as Selina Kyle/Catwoman and Richard McGonagle as Carmine Falcone, with additional characters and voice actors to be revealed throughout the series.
Batman – The Telltale Series is scheduled to launch digitally "this summer" on PC, Mac home consoles and mobile devices. Batman – The Telltale Series will also release as a special 'Season Pass Disc' (in a similar vein to Minecraft: Story Mode) allowing players to download all five subsequent episodes as they release.
Tagged as: Batman, Batman - The Telltale Series, Batman Announcement, Batman Screens, Batman Telltale Screens, Batman Voice Actor, Bruce Wayne, E3 2016, TellTale, Telltale E3
E3 2016: New Information on 'Star Wars' Game Development, 'Star Wars Battlefront 2' Announced
E3 2016: 'Titanfall 2' Collection's Edition Officially Revealed
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Illustration and full spread for Swarthmore College's winter 2016 publication featuring an article by Jonathan Riggs titled "Flying Blind" about Indiana bats. They wanted the cover illustration to feel fantastic and maintain a more realistic style for the inside spread that accompanied the article. Both illustrations were done primarily with gouache and ink.
Cover illustration and full spread Swarthmore College's winter 2016 publication featuring an article by Jonathan Riggs titled "Flying Blind" about Indiana bats. They wanted the cover illustration to feel fantastic and maintain a more realistic style for the inside spread that accompanied the article.


What makes Discover different from other carpet cleaners in San Antonio?
Comments: Comments Off on Why Choose Discover Carpet Carpet Care?
Comments Off on Why Choose Discover Carpet Carpet Care?
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Discover Carpet Care has quickly become one of San Antonio's top rated carpet cleaning businesses. The business owes its rapid success to owners who put attention to detail and customer satisfaction above all else. Anthony, John, and Alex knew the best way to grow their carpet cleaning business was to offer a high quality service and let their results speak for themselves. They invested in top-of-the-line truck mounted cleaning equipment that would allow them to get the best possible carpet cleaning results. As such, our customers can rest assured that no other carpet cleaners in San Antonio can do a better job than Discover Carpet Care.
One of the reasons Discover Carpet Care's customers have stayed loyal over the years is because the price they're quoted is the price they pay. Unfortunately, lots of carpet cleaners in San Antonio will quote you one price to convince you to schedule only to tack on fees once they arrive. At Discover Carpet Care, we pride ourselves on transparency. This means that when scheduling a customer, we ask about issues such as pet accidents and odors so that we can give an accurate quote. In almost all cases, the price you are quoted is the price you will pay. On the off chance of a change in price the technician will always let you know the new price before they begin and explain exactly why the price has changed.
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I've gotten quite a good water analysis from a friendly chemist at my local water plant. My water is very soft, and I would like to amend it with a touch of gypsum (calsiumsulfate), to bring up those two ions. I just wanted to check my thought pattern here: I will calculate the addition to the final amount of liquid left in the kettle, yes?
I have been learning to use https://sites.google.com/site/brunwater/, and it's quite handy once you understand what's what.
If I'm understanding you correctly, no you actually pre-treat the total water needed (TWN) prior to mashing (or during mash is fine I guess, but the additions are based on this volume).
In brunwater, it's hard to stuff this up ... because you enter what we refer to as TWN and VAW on the "water adjustment" tab. Then, your additions are calculated as gram/gallon additions relative to TWN.
The TWN is used for additions, and the VAW entered is only for color calculation I believe.
hmmm. If I calculate the amount of gypsum to add according to the TWN, then the ion concentration will be greater in the amount that goes to the fermenter. But that said, I am adjusting the ion balance for the mash, first and foremost, yes? For the mash to work in a certain way.
onkeltuka wrote: hmmm. If I calculate the amount of gypsum to add according to the TWN, then the ion concentration will be greater in the amount that goes to the fermenter. But that said, I am adjusting the ion balance for the mash, first and foremost, yes? For the mash to work in a certain way.
Is there any reason you are focused on the ion concentrations going into the fermenter?
If you choose a proper water profile for a given style/grist, and adjust your water according to the spreadsheet ... the proper considerations are made (mostly for mash pH, yes). If there is some reason you are worried about final concentrations, you might want to provide context as to why that even matters? If you ask me, it's irrelevant ... but maybe I'm missing something?
It sounds like you were given advice by somebody, but it's hard to tell how accurate that advice was without knowing its application relative to brewing.
Every brew is different, and there is no singular water profile that will guarantee a good result with every single type of beer. We need to know the beer style and desired water target before we can start thinking about adjusting.
I suggest reading the "water knowledge" page on brunwater site, as it informs you of everything I mention.
Last edited by Rick on 01 Aug 2014, 22:26, edited 1 time in total.
This water tinkering is just something to kill time with while I wait for my stuff to arrive so I can start brewing in the first place... I just like to read a lot (too much probably) and get side tracked to stuff that doesn't really matter (yet).
I'm just worried that as I saw how really soft my water is, if there's enough of all the good stuff for the malts to do their thing? For example my calsium is just 20ppm and sulfate is 24ppm.
onkeltuka wrote: This water tinkering is just something to kill time with while I wait for my stuff to arrive so I can start brewing in the first place... I just like to read a lot (too much probably) and get side tracked to stuff that doesn't really matter (yet).
No reason to worry. You have the water information, and you have brunwater. Brunwater will tell you if your water is good enough (or not).
Just enter all of the information and see what it tells you.
Last edited by Rick on 01 Aug 2014, 23:13, edited 1 time in total.
Well, from what I gather from Brunwater and "How to Brew" chapter 15, adding 0.2 grams of gypsum per litre will bring me closer to ball, not so that I wouldn't already be in the right ballpark, but still. And brewing an APA I guess the sulfate level can be a bit higher.
I'm not sure where you are now, but the pale ale profile within brunwater "requires" 300ppm sulfate. I've used that profile, and it makes a good APA.
Ok, I was looking at "Pale bitter" or "Amber bitter". But if I add 0.5grams gypsum per litre, then I'll be at 136 calsium 303 sulfate, which is pretty much perfect for the "Pale ale"! Excellent.
Getting back to this water stuff. One thing I can't get my mind around is this: when calculating mineral additions in BW, I calculate the mineral amounts based on the TWN, but once I'm done boiling I might have only 60% liquid of that left, so won't I end up with hugely concentrated amount of minerals in that smaller volume of wort?
I only have time to do one answer tonight and was about to jump in here with a 'fast' answer that I thought would be correct but, the above question, when you stop and think about it, well, at least to me, is revolutionary.
The question asks, "What should we end up with?" rather than, "What should we start with?"
What a great question .
I've got a few beers up my sleeve now so if it is not as revolutionary as I think, let me know, otherwise, any ideas?
John Kimmich's (brewer for The Alchemist) brew sheet for Heady Topper was spotted in a somewhat recent video, and it looks like he considers a final target as well. It's the only sense that I can make of that high alkalinity number coupled with "liquor profile".
But this is where I'm at with my thinking: first and foremost we want to get a certain pH for the mash, yes? We can do that with the malts, with acids like lactic acid or minerals like calcium etc. But the minerals we want also in certain amounts for the flavour, so we want the minerals to be at a certain level in the finished wort? Or is that last one wrong; does the effect that,for example, a high sulfate level gives to the hop aroma "happen" in the boil by affecting the chemical process the hops go through, or is it a certain sulfate level in the finished beer that somehow "makes" them taste like that? Is sulfate here something like salt in food, that it enhances the flavours of the other flavour compounds?
Could we first adjust the water with minerals to a level calculated to fit the projected VAW, and then get the final pH- drop in the mash with acidulated malt or lactic acid or something like that?
Onkeltuka, there is data that shows Calcium Sulfate enhances Hop Aroma and Flavor, and Chloride content enhances Malt-eness.
1-2 ounces of Black Barley will drop PH up to 2 levels in a 5 gallon mash....Of course it can darken beer 1-2 SRM.
I always thought (rightly or wrongly) that mineral additions were done purely to affect the mash. If they were meant to affect the fermentation then maybe there should/would be some post boil additions required (that I have never heard of)?
Maybe I am undersimplifying it!
Rick - Have I read that correct? 20 Gallons anticipated cellar loss?
Jesus! them draymen wil be staggering about!!!
Loving your thinking onke although it is a bit stream of consciousness - lol . I'm thinking the reverse of your last sentence but am on board with everything else. Get your mash pH correct with acids or whatever but aim your thinking of salts/flavours to work around VAW.
I'm a bit worn out now but consider that, the amount of water used in the mash by traditional brewers is about half of what we full-volume brewers use. I've no time to check it out but perhaps, this is another area where pure BIAB (full volume brewing) might be enlightening.
Last edited by PistolPatch on 13 Sep 2014, 20:23, edited 1 time in total.
onkeltuka wrote: I calculate the mineral amounts based on the TWN, but once I'm done boiling I might have only 60% liquid of that left, so won't I end up with hugely concentrated amount of minerals in that smaller volume of wort?
Look here at these Brew Strong episodes for more info on water. The 4-part series from 2009 is a great overall course in water (although there is a small amount of incorrect info); I just finished listening to it. In either part 3 or 4 of that series, JZ specifically says that the water should be adjusted pre-boil. Realize that if you're trying to replicate Pilsen or Dortmund water, that is the water characteristic you start with. If a brewer were using water of a certain mineral characteristic, all of the water (mash and sparge) would have the same mineral content.
Obviously, evaporation is the big variable, since higher levels of evaporation will result in higher mineral concentrations in the finished beer. You may just have to learn to make those adjustments based on experience. Then report back here with your findings. Bru'n Water identifies the same mineral adjustments for both mash and sparge (for the non-BIAB traditionalists who have both). I expect that experienced brewers may adjust their sparge additions or they may just back off on both the mash and sparge additions as you have.
I personally set my TWN as the mash volume in BW, 0 as sparge, and treat the whole TWN. For something like an IPA with high sulfate/chloride ratio, you can always back off on the total ppm while maintaining an approximate target ratio. The only thing that scares me about BIAB is that we are treating so much more water for the mash, so the total amount of minerals is pretty high.
I brewed 29L VIF of Tasty McDole's Janet's Brown Ale yesterday. He posted on the BN forum "FWIW, I raise RO water to Ca-110ppm, Mg-18ppm, Na-17ppm, SO4-350ppm, Cl-50ppm when I make JBA."
According to BW, my adjustments should have resulted in the following: Ca-66ppm, Mg-15ppm, Na-12ppm, SO4-153ppm, Cl-51ppm. I had to add 8g of gypsum, 6.6g of epsom salt & 4.5g of CaCl2 to 13.2 gallons (50L). This was a lot of additions, so I'd rather come up short rather than over-doing it, not to mention that Tasty is a bit more of a hop-head than I am. This is already a very hoppy beer, so I'm scared of overdoing the sulfate and over-accentuating. In essence, you and I are achieving the same result, whether by reducing the minerals based on volume or reducing the target ppm. I'd say that personal experience and perhaps info from other forums (and then sharing here) may be the key to learning more.
Last edited by cwier60 on 14 Sep 2014, 22:28, edited 1 time in total.
I wish I had the testing equipment to know how many parts per Million is in my water.
joshua wrote: I wish I had the testing equipment to know how many parts per Million is in my water.
I certainly don't. If your water comes from a consistent supply, you can either have it tested by Ward Labs, or check to see if your municipal water supply (assuming that's where you get your water) supplies this info. The municipal reports often only report on bacteria and things they are legally required to certify as being safe for drinking, not mineral content that's important to brewers. Also look at brewersfriend. Many people post the latest results from their water reports; maybe there is one from your area. Finally Google "water report joshua town" to see if anyone has posted anything. You could at least learn basic info about water for your south TN location.
Last edited by cwier60 on 14 Sep 2014, 23:06, edited 1 time in total.
Exactly, My Water department Guarantees the water is Safe......and All Minerals but Calcium are less than 100 PPM.
Knowing That, tells me to Remove the Chloramine with either Ascorbic acid, or Campden tablets, and add a few grams of table salt, to balance the Carbonate, and bring out the Malt.
I just listened to this again. Listen to Water Part IV starting at 58:00 for JP & JZ's explanation about volume of water to treat.
Last edited by cwier60 on 15 Sep 2014, 21:01, edited 1 time in total.
Won't I need 1,000,000 grams of water to add 1 gram of a mineral??????
Isn't 1,000,000 grams of water equal to 1000 Liters???
I am Confused about this water adjustment idea.
Joshua - That sounds about right to me.
cwier60 wrote: I just listened to this again. Listen to Water Part IV starting at 58:00 for JP & JZ's explanation about volume of water to treat.
Kind of confirms what I thought/wrote previously.
For us BIABers that is the TWN in the mash treated, 3V is mash plus sparge treated.
Last edited by mally on 15 Sep 2014, 21:25, edited 1 time in total.
ppm is basically equal to mg/L.


text:
Q: Django Custom Password Reset Form widget not working Stumped as to why my template isn't showing my custom password reset form.
Here is code:
forms.py
class CustomPasswordResetForm(PasswordResetForm):
def __init__(self, *args, **kwargs):
    super(CustomPasswordResetForm, self).__init__(*args, **kwargs)

email = forms.EmailField(
    label='', widget=forms.EmailInput(attrs={
        'placeholder': 'placetest@test.com',
        'class': 'form-field', }))

Views.py
class PasswordResetView(auth_views.PasswordResetView):
form_class = CustomPasswordResetForm
template_name = 'password_reset.html'

urls.py
urlpatterns = [
path('login/', LoginView.as_view(), name='login'),
path('password_reset', PasswordResetView.as_view(), name='password_reset'),
path('login_success/', login_success, name='login_success'),]

Template
{% load static %}
{% block title %}Home{% endblock %}
{% block content %}

Enter your email address

    <form method="POST">
        {% csrf_token %}

email

{{ form.email }}

        <input class="submit-button" type="submit" value="Send me instructions!">
    </form>

{% endblock %}

CSS
.form-field{
    width: 300px;
    height:30px;
    margin-bottom:5px;
    margin-top:5px;
    border:none;
    border-radius: 5px;
    background-color:whitesmoke;
}

Rendered HTML

Enter your email address

    <form method="POST">
        <input type="hidden" name="csrfmiddlewaretoken" value="TOKEN">

email

<input type="email" name="email" autocomplete="email" maxlength="254" required id="id_email">

        <input class="submit-button" type="submit" value="Send me instructions!">
    </form>

When I view the template in my browser, I am seeing the form field as the default, its almost like its just not recognizing the CSS class.
I'm not sure what I've missed.
.


McWane and Associates is a small privately owned engineering services firm established in 1975 to provide consulting services in welding, metallurgical, and materials engineering. Specifically the firm helps you design and build in quality by avoiding costly welding, metallurgical, and materials mistakes when designing, selecting and purchasing materials, establishing, specifying or performing welding, heat treating, forming, or other material fabrication methods.
Since 1999 the company has been answering technical questions and providing engineering support and consulting online through its' web site, in addition to serving clients at their locations.
Because the science of welding, metallurgy and materials does not change from one industry to the next, the company is able to continue to successfully serve a diversity of clients and industries, and therefore pass the benefits of this diverse industry experience on to you in the form of best industry practices.
Mr. McWane has more than 40 years of successful hands-on experience in the welding, metallurgical, and materials engineering field, and has held several engineering and teaching positions, plus practical experience as a welder.
Mr. McWane also holds a full time credential for teaching in the California Community College system, and has held certifications as a welder, welding inspector (QC1/CWI), and SNT-TC-1A level II certifications in radiography, ultrasonic, magnetic particle, and liquid penetrant examination methods.
He is a seasoned veteran who continues to gain valuable diverse industry knowledge and experience for the benefit of his clients. His knowledge and experience is continuing to help clients to successfully achieve their objectives.
While most welding engineers today go from high school to college without getting practical hands-on welding experience, Mr. McWane has the unique experience of making a living as a certified welder/fabricator for ten years before getting his bachelors degree. This unique and valuable experience gives him the ability and advantage of being able to look at any welding situation from the standpoint of both a welder, and welding engineer.


My name is Mark Sims I was diagnosed with Stage 4 malignant melanoma on the 18th of February last year at the age of 27. I'm a qualified doctor and my life has changed inconceivably over the last year and a bit.
Please give generously and spread your sunscreen copiously.
I just wanted to congratulate you on your incredible fundraising effort, it's amazing!!
I was hoping that I might be able to share some information with you about Trekstock a relatively new and small cancer charity aimed at supporting young adults (18-39) to thrive through and beyond cancer. I was diagnosed with melanoma (stage 3 – as it had already spread to several lymph nodes in my groin) last year. I had 3 surgeries but wasn't eligible for any clinical trials due to the date of my last surgery / the trial not yet being open. As a result of feeling totally lost and alone I went online and came across Trekstock. I have currently put my job as an F2 junior doctor on hold and I'm working for Trekstock for a few months.
Part of my job involves developing the new 'Young Person's Network'. This contains several links to a range of blogs and personal journeys – all young adults who have experienced cancer (you'll see a link to my cancer blog on there too). Currently I am the only young adult with melanoma in the network, however, given that skin cancer is the most common cancer in my age group, I know there are many other young adults in the UK in a similar position to me. It would be great if you might consider joining the network – and sharing some info about the network on your blog – so that other young adults with melanoma in the UK can support and connect with each other.
I'm a Producer at ITV's Good Morning Britain. We'd be really keen to have a chat about your story.
Just wanted to mention that the reason I sent my first email was because I read your story in Reveal and was really moved & wanted to help. I wish all the best in the future whatever you decide to do.
Thank you for providing this informative blog and for raising awareness.
I hope you don't mind me reaching out – i've kept up with your blog since watching a TV programme called before I kick the bucket on the BBC.
I was particularly interested as I also had a melanoma, in my case an early one that hasn't spread, although the experience of waiting on results of biopsies, lymph node scans etc was challenging enough for me to empathise to the best extent I can.
I also visited Saskia Reeken in Kingston – mentioned in an earlier blog of yours – who was excellent.
The reason I am getting in touch is that when I read you visited Saskia I figured you must live somewhere within touching distance of West London, where I live with my wife and children and run a corporate health company. Prior to this I spent 15 years as a Personal trainer and then a gym owner.
I am not sure what the position of your medical team (or yourself) is on the benefits of physical exercise in "wrestling melanoma", or even if it is a possibility for you whilst on treatment – but if I can support you with any physical training to help you build muscles, heart, lungs or whatever matters in your drive to progress (regression) and recovery, i'd like to help.
I'm embarrassed to say that I was completely ignorant on all fronts when the melanoma was found. Your blog was a real education for me when I was trying to work out what having melanoma meant or could mean – reading an account from yourself, a trained doctor, meant a lot to me as i'm sure it does to many, many other people – if I can provide any of the resources I have available in return, and help in any small way, that would be a pleasure.
I couldn't see anywhere to send you an email – which I would have preferred to do – which is why I posted here.
My email is daniel@bodyproject.com – I won't put my number up publicly but would be delighted to share it with you.
Hey, thanks for your message I'm very glad that your melanoma has not spread. I no longer live in West London. Unfortunately my body has wasted to a significant degree due to the side effects of the steroids. So I don't think I'd be able to take you up I on the kind offer.
I can't explain to you what I want to tell you. Just know you are something truly special.
Dearest Mark and family – all my love to you all. I have followed this blog since Mark started writing it and have been cheering him on during all the many victories along the way. A truly wonderful and inspiring man, a credit to you all. May he rest peacefully.
I would like to personally congratulate you as your blog Wrestling Melanoma has been selected by our panelist as one of the Top 70 Melanoma Blogs on the web.
I personally give you a high-five and want to thank you for your contribution to this world. This is the most comprehensive list of Top 70 Melanoma Blogs on the internet and I'm honored to have you as part of this!


text:
Le 31 juillet 1923, l'Automobile Club de France crée la Fédération Nationale des Clubs Automobiles de France (F.N.C.A.F.). Son objectif est de fédérer les Automobile-Club régionaux.

Son siège se situe au sein de l'Automobile Club de France (ACF) au 8, place de la Concorde à Paris.

Sa dissolution a lieu le 15 janvier 2009.

Membres Fondateurs

Automobile Club de France et les Clubs Régionaux :  Automobile-Club ardennais, Automobile-Club armoricain, Automobile-Club d'Auvergne, Automobile-Club bordelais, Automobile-Club bourguignon, Automobile-Club de la Corse, Automobile-Club des Côtes-du-Nord, Automobile-Club dauphinois, Automobile-Club du Gard, Automobile-Club d'Île-de-France, Automobile-Club limousin, Automobile-Club lorrain, Automobile-Club de Marseille, Automobile-Club de Nice, Automobile-Club du Nord de la France, Automobile-Club du Périgord, Automobile-Club de Picardie et de l'Aisne, Automobile-Club du Rhône, Automobile-Club de Toulouse et des Pyrénées, Automobile-Club vauclusien, Automobile-Club vosgien.

Objet de la Fédération
Cette fédération avait pour objet de fédérer les Clubs Automobiles de France et d'ouvrer à une action concertée en vue de la Défense des automobilistes et de l'étude de toutes les questions relatives à l'organisation générale du sport et du Tourisme en France.

Fond de course Automobile

Pour contre-carrer les voitures de course de l'Allemagne nazie, la commission sportive de la F.N.C.A.F. décide de créer un fonds de course Automobile, dédié aux constructeur français. Cette cause deviendra nationale à l'approche de la  Guerre mondiale lorsque les Auto-Union soutenues de façon considérables par le Troisième Reich ont remporté un grand nombre de courses automobiles.

Fonds de course Automobile (Prix 1 million de Francs)
 1937 - René Dreyfus
 1938 - René Dreyfus

Fonds de course motocycliste ()
 1938 - Monneret

Effectifs

En nombre d'adhérents
 1948: 254 711
 1957 : 662 559
 1958: 698 154
 1966 : 711 109

Liste des clubs membres avec année de création

Notes et références

Voir aussi

Articles connexes
Touring club de France
Automobile Club de France
Automobile Club Association

Organisation du sport automobile
Club automobile
Association ou organisme lié au secteur du transport en France
Association de consommateurs en France
Lobbyisme


Victor Andrews, who is legally blind, is the lead plaintiff in a series of putative class action lawsuits recently filed in federal court against nearly a dozen businesses in the retail and hospitality industries. The lawsuits allege that the businesses' websites are inaccessible to Mr. Andrews and therefore in violation of Title III of the Americans with Disabilities Act of 1990 ("ADA"), the New York State Human Rights Law ("NYSHRL"), the New York State Civil Rights Law, and the New York City Human Rights Law ("NYCHRL").
These lawsuits are part of a rapidly growing trend in the area of internet, technology and website accessibility litigation. In fact, the Wall Street Journal reported in 2014 that accessibility lawsuits had increased by 55% from the prior year. In 2015, the United States Department of Justice ("DOJ") received over 6,000 accessibility complaints, representing a 40% increase from the prior year. More recently, the New York Times reported that, since January 2015, over 750 accessibility lawsuits have been filed in federal court.
By way of background, Title III of the ADA provides that "[n]o individual shall be discriminated against on the basis of disability in the full and equal enjoyment of the goods, services, facilities, privileges, advantages, or accommodations of any place of public accommodation." Similarly, the NYSHRL and NYCHRL generally make it unlawful for the owner, manager, agent or employee of any place of public accommodation to deny a person, because of disability, the accommodations, advantages, facilities or privileges of the place of public accommodation.
At issue in most of these website accessibility lawsuits is whether the website is a "place of public accommodation" within the meaning of federal, state, and local disability laws. Because the ADA was passed in 1990, there is no reference within the statute to the internet or websites. The DOJ has taken the position that the ADA applies to the internet and web-based goods and service providers; however, the DOJ has delayed promulgating regulations that would codify its position, and it appears unlikely to happen any time soon, particularly after the Trump Administration's DOJ placed web regulations on its list of "inactive" agenda items this past July. In the absence of clarity from the federal government, the resolution of this issue has generally been left to the courts, resulting in varying judicial interpretations and conflicting decisions.
The Courts of Appeals for the Third, Sixth, Ninth, and Eleventh Circuits hold that the statute is unambiguous: "places of public accommodation" are physical structures, and the only goods and services that a disabled person has a "full and equal" right to enjoy are those offered at a physical location. Discrimination only exists if the discriminatory conduct has a "nexus" to the goods and services of a physical location. . . . By contrast, the Courts of Appeals for the First and Seventh Circuits, while also holding that the ADA is unambiguous, reach the conclusion that "places of public accommodation" need not be physical structures, and discrimination may occur when the goods or services of a "place of public accommodation" are enjoyed by customers who never visit a physical location.
No. 17-CV-767, 2017 U.S. Dist. LEXIS 121007, at *11-18 (E.D.N.Y. July 31, 2017). Notably, the Second Circuit Court of Appeals, which has appellate jurisdiction over the federal district courts in New York, has not addressed the precise issue of whether a website should be considered "a place of public accommodation," but it has indicated, in the context of whether the ADA "regulates insurance underwriting practices," that it may share the view of the First and Seventh Circuits. See Pallozzi v. Allstate Life Insurance Co., 198 F.3d 28 (2d Cir. 1999).
That said, the recent trend of courts liberally interpreting the ADA's "place of public accommodation" requirement can be found in National Federation of the Blind v. Scribd, Inc., 97 F. Supp. 3d 565, 576 (D. Vt. Mar. 19, 2015). The National Federation of the Blind (the "Federation") brought suit against Scribd—a digital library that operates reading subscription services on its websites and apps for mobile phones—alleging that Scribd's content violated Title III of the ADA because it used an exclusively visual interface and lacked any non-visual means of operation. Id. at 567. Scribd moved to dismiss the Federation's complaint, contending that it had not alleged facts demonstrating that Scribd "owns, leases, or operates a place of public accommodation" since its services are provided exclusively online. Id. The court disagreed with Scribd and denied its motion to dismiss. In doing so, the court dismissed Scribd's argument that "since all of the examples listed in [the statute] are physical places, Title III of the ADA only applies to discrimination occurring at a physical place. . . ." Id. at 569. The court stated that "[r]equiring a physical structure or some connection to a physical threshold would result in arbitrary treatment. For example, it would make little sense if a customer who bought insurance from someone selling policies door to door was not covered but someone buying the same policy in the parent company's office was covered." Id. Next, the court looked to the statute's legislative history to conclude that its drafters did not intend for it to apply only in the physical realm, noting the purpose of the law—i.e., "to end widespread discrimination" and to implement a program to address the "compelling need for a clear and comprehensive national mandate to eliminate discrimination against disabled individuals. . . ." Id. at 573 (internal quotations omitted). Furthermore, the court noted, the Committee Report explicitly stated that "the types of accommodations and services provided to individuals with disabilities . . . should keep pace with the rapidly changing technology of the times." Id. at 574 (citing H.R. Rep. 101-485(II), at 108).
More recently, on June 12, 2017, a federal judge out of the Southern District of Florida entered a first-of-its-kind verdict, finding that grocer Winn-Dixie violated Title III of the ADA by having a website that could not be used by the visually impaired plaintiff to download coupons, order prescriptions, or find store locations. Gil v. Winn-Dixie Stores, Inc., 2017 U.S. Dist. LEXIS 90204 (S.D. Fla. June 13, 2017). Three days later, on June 15, 2017, a federal judge out of the Central District of California found that Hobby Lobby failed to provide disabled individuals with full and equal enjoyment of goods and services offered by its physical stores by not maintaining a fully accessible website. Gorecki v. Hobby Lobby Stores, Inc., 2017 U.S. Dist. LEXIS 109123 (C.D. Cal. June 15, 2017). Notably, however, the decision in Gorecki is in stark contrast to a recent decision reached by a federal judge in the same United States District Court. See Robles v. Domino's Pizza LLC, 2017 U.S. Dist. LEXIS 53133 (C.D. Cal. March 20, 2017) (holding that requiring Domino's Pizza to provide an accessible website in the absence of a clear regulation would violate the company's constitutional right to due process).
Although the trend appears to be shifting toward a more liberal interpretation of the phrase "place of public accommodation," the absence of clear direction from the DOJ or the courts leaves businesses in a difficult position. Modifying an existing website or designing a new website to accommodate individuals with disabilities can be both a time-consuming and expensive undertaking, and ultimately may not be required if the courts or DOJ adopt a different website accessibility standard. That said, conservative businesses that design or operate websites (and mobile applications) are taking steps to ensure that the technology is accessible to individuals with disabilities and otherwise compliant with federal, state, and local disability laws. Such steps include conforming all web content and services with the Web Content Accessibility Guidelines, available here, at least until the DOJ promulgates regulations governing website accessibility.
Should you have questions regarding the information presented in this alert, please contact Robert J. Thorpe at rthorpe@barclaydamon.com or Laurence B. Oppenheimer, Chair of the firm's Labor & Employment Practice Area, at loppenheimer@barclaydamon.com.


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Timeline: Celina Cass investigation
Updated: 3:56 PM EST Feb 27, 2017
KC Downey
On July 26, 2011, 11-year-old Celina Cass was reported missing. She was taken from her home in Stewartstown.
Cass's family members said that she was last seen on the family computer the night she vanished. She and her sister Kayla shared a basement bedroom, but Kayla was away at a friend's house.
PHOTO: NH State Police
The last time Celina was seen alive, she was inside her home, where she lived with her mother, stepfather and sister. The family has since moved, and the house has new tenants.
Soon, more than 100 people from state police, FBI, NH Attorney General's office and others were called in to help in a massive search effort for the 11-year-old.
PHOTO: Colebrook Chronicle
Celina's family stayed out of the media spotlight during the investigation. Everything was searched from the family's cars to their home.
Authorities also searched for Celina by air.
Cass's face was spotted all over the region on these "Missing" posters.
Missing posters were placed across town.
The small town was devastated to hear that the young girl was missing. They all wanted answers as to what happened to her and why.
State police, FBI. the attorney general's office, and residents of Stewartstown combed through miles of land and water to find Cass.
On the morning of Aug. 1, 2011, Celina's biological father, Adam Laro, who discovered the young girl missing from their home, shared a few words with the media.
Hours after Wendell Noyes spoke to the press about his missing stepdaughter, he was rushed to the hospital for an undisclosed reason.
Dive teams search the Connecticut River in the hopes of finding Celina.
PHOTO: WMUR
After 6 days of searching, on Aug. 1, 2011, Celina's body was found in the depths of the Connecticut River, not far from her home. Her body was wrapped in a blanket and she was still wearing her pajamas. Her death was labeled as suspicious.
Wendell Noyes' truck was taken away by investigators.... The second vehicle taken from the property that week...but investigators didn't reveal why.
According to police records, in 2003, Noyes was diagnosed with schizophrenia and was committed to a hospital. Louisa says that he took his medication daily for his condition.
As the investigation continued, Celina's family laid her to rest and the community gathered to remember a young life lost.
Assistant Attorney General Jane Young announced a $30,000 reward in the Celina Cass case and said the public is able to make donations.
Louisa was never called to testify before the Grand Jury, but she did take and pass a lie detector test.
Louisa also said that she was frustrated with the lack of information investigators gave to her during the case and she never saw Celina's body after she was found.
Louisa visits her daughter's grave three or four times a month and she says is helps her feel close to Celina.
Until June 2016, not a single person of interest had ever been named in this case. Tomie Noyes (Wendell's mother), Wendell Noyes, Wendell's sister and his brother were all called to testify before a grand jury in January 2012.
Wendell and Louisa were married for nine months before Celina went missing, but living together for a couple of years prior to the wedding. They are now divorced and Louisa and Kayla live in Vermont, while Noyes lives close by.
Crews battled a fire Dec. 2, 2013, at the West Stewartstown home where Celina lived when she disappeared in 2011.
Celina's stepfather, Wendell Noyes, was arrested June 20, 2016, in connection with the girl's killing.
On Feb. 27, 2017, Noyes was found not competent to stand trial, so charges were dismissed. If he is ever found competent, charges could be brought against him again.
Charges dismissed against stepfather accused of killing Celina Cass
See a full timeline of the search for and death investigation of Celina Cass.


— Leonard Cohen, "The Future"
A Bad Future is one of the most common Alternate Timelines and one, who if Time Travel exist in their universe, any stars of a long-running series will surely visit. The heroes are sent into the near future (common intervals are 5, 10, and 20 years), and discover a Crapsack World. Usually the villain(s) have taken over. They may even encounter themselves. 90% of the time the hero(es) will meet La Résistance and/or Future Badass versions of his friends who were left in the past. Typically they go back in time to Set Right What Once Went Wrong.
Technically Dystopian, but doesn't fit that trope description well as it's usually ascribable to a single villain-related event. It's a good (or cheap, depending on the execution) way of becoming Darker and Edgier and adding tension while working under Status Quo Is God. If a series gives only a brief glimpse of the Bad Future instead of actually going there, it may be Storyboarding the Apocalypse.
If this happens to a character from the past to "our" future, then they've entered a Bad Present. If the reason the bad future is so bad is because The Bad Guy Wins, it's a Villain World. Sometimes the characters find out about the Bad Future via an Ominous Message from the Future rather than Time Travelling themselves.
Compare with Future Me Scares Me, Dark World, Techno Dystopia, It's a Wonderful Plot and Mirror Universe.
Aladdin: The Series: villain Abis Mal goes back in time, teams up with his own ancestor Abnor Mal, and tries to replace the current sultan's family as founders of Agrabah. Both of them being rather inept however, their plan does not work and is, as always, foiled by Aladdin.
Meet the Robinsons, with the alternate future ruled by a robotic bowler hat. Specifically, when the Bowler Hat Guy takes credit for Lewis's Memory Scanner, he unwittingly helps Doris and her demonic, robotic bowler-hat offspring destroy the bubblegum neo-fifties Zeerust future in favor of a dystopian future. Bonus points for a Future Badass mind-controlled Robinson family. You can tell they're Future Badass because all the women wear black lipstick.
One of those rare inversions drives the plot of Bill & Ted's Excellent Adventure: the good future is in danger of not happening if Bill and Ted don't get to start their band.
Inverted in Hot Tub Time Machine, as the movie starts out in one. Nick works a dead-end job of cleaning dogs' anuses, Jacob lives in his uncle's basement, and Lou's life is so bad, he attempts suicide. At the end of the film, Nick lives his dream of being a musician, Lou becomes a billionaire by exploiting what he knew would happen after the '80s, and Jacob lives with his rich father.
The premise of X-Men: Days of Future Past is preventing a horrific dystopian future by changing past events.
Thrill Seekers: After a reporter finds out that tourists from the future are visiting disasters in his own time, he actively seeks to prevent these events. Two agents travel back to stop him from changing anything else. Their boss at one point calls them up from the future which is now overpopulated, polluted, and had bad people get voted into power.
Time Runner: In 2022, the Earth is invaded by a race of aliens who have already infiltrated most layers of society by posing as humans. A wormhole allows the hero to go back in time to Set Right What Once Went Wrong.
Frodo sees a bad future of the entire Middle Earth conquested by Orcs looking at Galadriel's fountry in Peter Jackson's The Lord of the Rings, this is film only as is not in the books.
In Conciencia y Voluntad the future isn't very bright: economical crisis and warfare has bring down most nations, and a catastrophical technological disaster (Massive EMP) get back the technology level at an incertain point between 1950 and 1980, although many of the knowledge is saved.
The book features a possible bad future, observed during Aviendha's final tests to become a Wise One. It seems that her descendants become embroiled in a war with the Seanchan Empire, who have acquired gunpowder weapons, conquered Tar Valon and subjugated the rest of the world. Decades or centuries later, the once-proud warrior Aiel have been reduced to scavengers living off the refuse of the Seanchan and their vassals.
One of the legs of the White Tower's Accepted test is apparently designed to invert this trope. The women taking the test are shown an ideal future where they're not part of the White Tower but have to decide to abandon it in favor of staying.
Averted in The Pendragon Adventure, where part of Bobby's quest in the third book involves talking to a contact from the year 5010, which is a nice time to live. Played straight later on, when Saint Dane's meddling changes timelines in multiple territories.
In Obsidian Mirror, Sarah is from one. She travels back in time to try and prevent it.
The Buffy the Vampire Slayer serial novel, The Lost Slayer had Buffy make a tactical mistake trying to rescue Giles, then get sent five years into the future, to her older self's body, to see a world where Sunnydale was ruled by vampires—with Giles as their king.
The Forever War: The effects of the war cause Earth to fall further and further into chaos, getting more and more Crapsack as the war drags on—every time Mandella returns to Earth from one of his deployments light years away, he becomes more and more estranged.
The hero of the Belisarius Series is given a number of visions of what will happen if he fails to defeat the Malwa. They range from the horrific to the apocalyptic.
The Queen of Rolitania and her army manage to escape a future filled with an Earth ruined beyond repair. A good portion of those considered "normal" are dead. Espers have ravaged the landscape with their reality-warping powers. Marauding bands of crazed Espers roam freely and often clash.
Clover Lappina of Spectral Shadows gets a vision of one of these for Suburbia, and how she can be the cause of it.
In TimeRiders, it's constantly referenced that in the 2070s mankind is all but wiped out by the Kosong-Ni virus. Rashim is even close to witnessing it first hand.
The Time War in the Doctor Who – Expanded Universe Eighth Doctor Adventures (not to be confused with the Last Great War in the RTD TV series) is a Bad Future for the whole Doctor Who universe and the Time Lords in particular, which dominates the first half of the series before getting averted in The Ancestor Cell by Justin Richards.
In Super Powereds, Alice and Mary are shown a glimpse of a possible future, where humans, Supers, and former Powereds start a Mêlée à Trois that devastates the world. What's worse, it's only three decades away. And they are the key figures who might have a chance of preventing it.
In All Our Yesterdays, Em is trapped in one thanks to James, and goes back in time to avert it.
"Consider Her Ways" by John Wyndham. The narrator agrees to take part in clinical trials of an hallucinogenic drug which causes dissociation from the body, and wakes up in a post-Gendercide world where society has been totally restructured into something more closely resembling an ant's nest. It's explained to her that the plague that wiped out all men in this future was caused by a mutation of a virus created to kill off brown rats. When the narrator returns to her body, she seeks out the researcher whose work caused the plague and murders him, not realizing that he had a son who did similar research and, of course, had the same name as him.
Robot features a Robot War between the remains of humanity and an army of Humongous Killer Robots, while once-great cities lie in ruins on the horizon.
Two are scene in the second arc of Sequinox during the team's battle with Gemini, who distrcts them by constantly clapping them into different dimensions and timelines. In one, the girls find themselves in a world where they agreed to join the Sky Queen and have razed Westbrook and the surrounding area, becoming very powerful but also very, very evil. In another, they're After the End and have to act as a militia against the entirety of the Star invasion force.
At the beginning of the A Touch of Darkness from Interstitial Actual Play, a Homura from the future appears, warns her past self not to speak with Hiram Lodge, and is then dragged back through time by a clawed hand and killed. Homura isn't phased, since it happens to her a lot.
The Big Finish Doctor Who audio drama The Mutant Phase has a similar event to the Day of the Daleks, a Stable Time Loop causing an alternate future where the Daleks are mutating into creatures even more dangerous then them.
At the end of the primary phase of The Hitchhiker's Guide to the Galaxy, Ford Prefect tells the Golgafrinchams (with whom he and Arthur Dent have landed in prehistoric days) that their days as the human race will be numbered in 2 million years when the Vogons destroy Earth.
Bleak Expectations: An unusual one, caused deliberately by the heroes. At the end of series 4, Pip Bin sides with Mr. Benevolent in taking over the world, which lasts for decades, until mankind collectively gets fed up with them and decide they'd rather risk total annihilation than live under Pip and Gently's rule. It takes divine intervention (and a What the Hell, Hero? from God Himself) for Pip to go back and prevent it.
Rifts is this to prequel game Beyond the Supernatural, which is set in the present day. Victor Lazlo, a parapsychologist who got time-shifted from the 1970's to this future is horrified when he meets, and is recognized by, an old friend (who was secretly a dragon) and realizes that this is his world's future, and not just an alternate one.
Sentinels of the Multiverse has a few plot points involving the Bad Future. Visionary came from the Bad Future to the past in order to prevent it, while Iron Legacy (from another, separate future) is what Legacy would become if Young Legacy was killed by Baron Blade. Chrono-Ranger was just a lawman from 1883 who was sent to a third, distant Bad Future where humanity was wiped out whose goal is to time travel and kill the monsters of the past before they take over the future. The last one is the only ine that is actually a bad future of this specific timeline. The others were alternate timelines. However, since chrono-ranger has been altering the past this one is also quickly becoming an alternate timeline.
Harry Potter And The Cursed Child, Albus and Scorpio use a time turner to save Cedric's life, as Cedric's father begs them. Unfortunately they cause him so much humiliation in the process that he joins the Death Eaters and kills Neville, so no one kills Nagini, Voldermort kills Harry and Take Over the World..
Clock Zero has one, as a direct result of an alternate Nadeshiko getting into a coma from a car "accident" and alternate Takato going through extreme lengths to save her and prevent the same thing from happening to her again, even if it means he has to commit downright ruthless acts in doing so. King's attempts of preventing the aforementioned incident from happening kickstarts the VN's plot.
In Higurashi: When They Cry, the first episode of the second season features a destroyed Hinamizawa, an aging Oishii going back there to find out what went wrong accompanied by a grieving, regretful Akasaka and a broken, nigh catatonic, middle- aged Rena.
In a series with plenty of Bad Endings, the third arc of Umineko: When They Cry leads to a Bad Future that is inextricably tied to the fourth arc thanks to the miracle of Time Travel (or maybe not). By the end of the series, it's clear that this particular future is in fact the future in this series, with no way to avoid it happening. Despite everything that happens, though, there is an undercurrent of happiness at the end.
Steins;Gate has two: time travel research by CERN leads to them using time travel to take over the world and establishing a communist dystopia. The protagonists' actions prevents this and inadvertently causes every country in the world to race to become the first with a working time machine, which touches off a hellish World War III that kills 5.7 billion people.
For Time players, this is the result of not keeping Stable Time Loops Stable, since any divergence from the main "Alpha" timelinenote (not to be confused with the Alpha universe or the Alpha session) will inevitably result in the timeline in question being destroyed and everyone in it dying along with everything else. John, however, recently obtained the power to alter events in canon without dooming a give timeline.
All of the prior examples are overshadowed by the Game Over Timeline, the mother of all Bad Futures. This timeline pretty much makes every other doomed timeline look like a walk in the park. There are prior clues that the timeline is going down the drain, such as Gamzee going unpunished for his crimes, Terezi entering an abusive relationship with Gamzee, and Rose developing an alcohol addiction. But even in light of these clues, what is probably the biggest Wham Episode in Homestuck, the aptly-named [S]GAME OVER, is still unexpected. Jane and Jade become Brainwashed and Crazy, several planets are smashed together and set entirely on fire, Dirk commits suicide, and every single one of the heroes except John and Roxy die. The cause? Terezi trying to save everyone's life by killing Vriska before she could accidentally lead Bec Noir to their hideout. The faults in the timeline run so deep that John has to rewrite three years of his and his friends' lives via Butterfly of Doom to Set Right What Once Went Wrong.
There's a future in which superintelligent dinosaurs rule the world and most of the characters are either dead or part of La Résistance.
Chuck Goodrich came to the past the first time around to prevent the Zombie Apocalypse, but instead ended up branching the universe into a split timeline where another Chuck Goodrich comes to the past to prevent his own future, and so on. Because if the zombies don't destroy the future, the robotic vacuum cleaners will, and if they don't, then the superintelligent dinosaurs will. This seems to be a constant of all timelines, with each subsequent Chuck Goodrich (and it's always Chuck Goodrich) only diverting from one potential bad timeline to the next. This includes King Radical, whose goal is to save his kingdom from the Bad Future where Sparklelord destroyed everything.
In Powerpuff Girls Doujinshi, there's at least one timeline where Megaville and everyone in it are slaughtered due to one of the heroes performing a Face–Heel Turn. Said timeline is explored in a spinoff to its sister comic, Grim Tales from Down Below.
Seeing one of these with her as the cause is what starts off Kendra's Face–Heel Turn in To Prevent World Peace. In said future Kendra would lead other Magical Girls to destoy all villains and then Take Over the World, supposedly for its own good.
Girl Genius has one of these, through not in the main comic, but on Othar's twitter. Apparently in this future Lucerezia manages to take over Agatha's body for good and marries mind-controlled Klaus, gaining control over Europa. Many years later Europa is completely deserted, with only a handful of survivors hiding in the remote corners of the continent.
The Dark Future story in Deviant Universe where an evil AI all but destroys all life on Earth.
In Luminary Children, Earth is in poverty and the galaxy is ruled by a corrupt government that hunts down kids.
In Wayfarer 1805, would-be writer "Tussel" Lee learns she's somehow responsible for three different bad futures: one in which Earth is fighting a losing war against an Alien Invasion, one in which it's been subjugated by an all-knowing moon-sized supercomputer, and one in which the planet is slowly freezing to death in a new ice age. This news doesn't bother her as much as the fact that she doesn't finish the novel she's working on in any of them.
The SCP Foundation developed a time machine labeled SCP-2003 and learned that in January 2349 humanity gets wiped out by an asteroid. They then begin to desperately ensure that this takes place because every possible future they encountered managed to be even worse, excluding one with a depopulated but more advanced human race that they're still investigating.
New Vindicators has several of these. First, there's the future of Hikari's alternate dimension-where Apocatasis wins and rules most of the world. Then, there's the one where Jason Lamperouge has manipulated most of the heroes and villains in one way or another and culminates in the death of most of the Vindicators, Jason himself, and a few others dimension hopping and unable to get back. Lastly, there's the far future where Sol Invictus, an immortal Neo-Sapien, rules over an empire with his family, the Pantheon, as god kings. Humans are treated as second class citizens, and by the time Sol Invictus is eventually stopped, most of the heroes are dead as well.
One of The Angry Video Game Nerd christmas episodes parodies A Christmas Carol by having the Ghosts of the Past, Present and Future Christmas show the Nerd his never ending cycle of getting tortured by bad games, beginning with his childhood. The last ghost (which turns out to be Dracula from Simon's Quests) shows the Nerd a bad future in which he continued to complain about games all the way up to the Wii, even starting to enjoy it.
The Onion's Future News From the Year 2137 . Wyoming nuked itself by popular referendum after gay marriage was legalized, there is one Palestinian and one Israeli left on Earth in the Gaza Scrap, and the United States is building a particle accelerator to create a black hole in the Earth to end everyone's suffering.
Zesty Lewis: Meanwhile, criticalism is piling up near the president, who was voted into office for a sixth time primarily because he promised to kill us all.
Lewis: President's Wilsons approval ratings have gone down steadily since the delays, excepting a small rise when he personally murdered 7,000 people with a hatchet.
The Nostalgia Critic's review of The Room features one ruled by seahorses.
Played with in Dragon Ball Z Abridged. The future where the Androids conquer the Earth is just as horrible as it was in canon, but Future Gohan doesn't consider it to be the "bad" future. His friends were constantly dying all around him long before the Androids ever showed up, so to him, it's just "the future." Other than that, it's pretty much the same, except Yamcha, rather than being killed by the Androids, hangs himself when he finds out Trunks' father is Vegeta.
In "10 EPIC BATTLES that Changed History FOREVER!" by Matthew Santoro, Matthew returns from the future only to be freaked out by the fact that the future was taken over by robots.
Society of Virtue parodies it in the episode Undesired Days Of Future Past and plays it straight in Season Finale.
Well, we just got back in our Time Machine and, hahahaha, you guys are so boned. Oh yes, especially you.