text:
Q: Como subir imagen a servidor node.js, usando expo-image-picker y typescript Busco subir una imagen desde react native, usando la libreria expo-image-picker, a un servidor node.js que utiliza multer para procesar archivos. Una vez en el servidor, quiero subir la imagen a AWS.
He hecho este proceso completo con react web de forma exitosa. Sin embargo, con react native,
el archivo que recibo en el servidor (req.file) llega como undefined.
Este es el codigo que estoy usando:
//sendImage.tsx

import { useState } from 'react';
import {View, Text, Button} from 'react-native'
import * as ImagePicker from 'expo-image-picker';
const sendImage : React.FC = ()=>{

        const [picture, setPicture] = useState<string>('')

        const pickImage = async ():Promise<string|boolean> => {
          // No permissions request is necessary for launching the image library
          let result = await ImagePicker.launchImageLibraryAsync({
            mediaTypes: ImagePicker.MediaTypeOptions.Images,
            allowsEditing: true,
            aspect: [4, 3],
            quality: 1,
          });

          console.log(result);

          if (!result.cancelled) {
            setPicture(result.uri);
            return result.uri
          }
          return false
        };

        const sendPictureToServer = async () => {
            const formData = new FormData()
            formData.append('file', picture)
            const result = await fetch(`http://localhost:5001/dashboard/chooseProfilePic`, {

                method : 'POST',
                body : formData
            })

        }
    return(
            <View>
                <Text>Change profile picture</Text>
                <Button title = 'select' onPress={pickImage}/>
                <Button title='send' onPress={sendPictureToServer}/>

            </View>
    )
}

Este es el lado del servidor
//
//  routes/dashboard.js
const {Router} = require('express')
const router = Router()
const multer= require('multer')
const upload= multer({dest:'uploads'})

router.post('/chooseProfilePic', upload.array('file') , controller.chooseProfilePicture)

// controller/dashboard.js
chooseProfilePicture : async(req, res) =>{
        const id = req.params.id
        console.log('this is the file',req.file) //imprime undefined

        const url = await bucket.uploadProfileImage(req.file, id)
        console.log(url)
    },

A: tienes que agregar el Content-Type asi:
        const sendPictureToServer = async () => {
        const formData = new FormData()
        formData.append('file', picture)
        const result = await fetch(`http://localhost:5001/dashboard/chooseProfilePic`, {

            method : 'POST',
            body : formData,
            headers: {
              'Content-Type': 'multipart/form-data',
            },
        })

    }

redpajama_set_name: RedPajamaStackExchange


Unite Your Local Creative Community. The Egotist Network is an exclusive platform built specifically to feature the work, talent, resources and point-of-view of your local creative market – wherever it may be.
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A starting point for the production of our packaging is high quality cardboard. It determines the aesthetics, functionality and durability of the packaging. As cardboard quality is of top priority to us, the paper used for cardboard production is also of premium quality and is sourced from the best suppliers in Europe. Another factor is our BHS and Fosber corrugated board production lines located in the plants in Geater and Lesser Poland. However, people are an asset that matters most in the entire production process and our corrugator operators are valued professionals possessing outstanding technical abilities in the field.
The offered range of corrugated board types, however, goes much beyond the standards.
hydrophobic corrugated board (impregnated) used when corrugated board needs to be waterproof (corrugated board for fruit and vegetable market, lockers, maritime transport etc.). It is possible to have corrugated board cold or hot impregnated, we can also use waterproof paper.
High quality corrugated board is mainly used by us for the production of our own corrugated board but as we are aware of its value you can also find it in our offer available as a finished article for other processors converters.


Check out our orthodontic rewards program!
Welcome to our new and improved patient rewards program, Patient Rewards Hub! Like our former Orthobucks program, the Patient Rewards Hub is designed to recognize and reward our patients' hard work through orthodontic cooperation, academic achievement, community involvement, and much more.
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This consensus paper provides an overview of the state of the art in research on the aetiology and treatment of nightmare disorder and outlines further perspectives on these issues. It presents a definition of nightmares and nightmare disorder followed by epidemiological findings, and then explains existing models of nightmare aetiology in traumatized and non‐traumatized individuals.
Chronic nightmares develop through the interaction of elevated hyperarousal and impaired fear extinction. This interplay is assumed to be facilitated by trait affect distress elicited by traumatic experiences, early childhood adversity and trait susceptibility, as well as by elevated thought suppression and potentially sleep‐disordered breathing. Accordingly, different treatment options for nightmares focus on their meaning, on the chronic repetition of the nightmare or on maladaptive beliefs.
Clinically, knowledge of healthcare providers about nightmare disorder and the delivery of evidence‐based interventions in the healthcare system is discussed. Based on these findings, we highlight some future perspectives and potential further developments of nightmare treatments and research into nightmare aetiology.
As registered user, you can create one (or more) information-profiles, with which we can keep you informed with news on the subjects that you are interested in.
Click on my personal page to register yourself.


text:
Jaime Iván Martínez Betancur (born 1972), known as The Guarne Killer and The Monster of the East, is a Colombian serial killer. He was responsible for the murder of several people, including the killings of his wife and children. The bodies of the victims were exhumed by specialized personnel of the Attorney General's Office, in cooperation with the Technical Investigation Body (CTI), the Unified Action Groups for Personal Liberty (GAULA) and police dogs, who conducted on-site investigations as part of the procedures.

The Colombian authorities suspect that he has killed between 20 and 25 people for a decade. He was sentenced to 42 years in prison by a specialized court in the Antioquia Department.

Crimes
It is believed that Martínez committed between 20 and 25 murders in the span of a decade. One of the victims was identified as Natalia García Gil, Martínez's former wife, whom was hanged with the use of nylon. The other people were murdered in the same way, including children who were 5 and 7 years respectively, all of whom were killed in November 2015. It was also established that María Gladis Arango was another victim, who disappeared in mid-January 2016 in a village called Hoja Anche de Guarne, in Guarne. Due to Arango's disappearance, the Colombian authorities imposed an "assurance measure for the crime of enforced disappearance", which allowed for a more detailed follow-up investigation.

According to the investigating authorities, Martínez buried most of his victims in potter's fields at depths of 3 meters, wrapped in several yards of canvas, at a farm where he worked, as a method to forcibly hide the bodies. Nevertheless, according to his own confessions, he claimed that others were buried in two farms near the place where he lived. He also collected objects and personal elements of his victims such as watches, smart phones, jewelry, etc.

He was captured in Guarne by specialized personnel of the CTI, very close to the eastern subregion of Antioquia Department in a farm where he worked as a majordomo and guard, the same place where he committed several of the murders, although it is believed that he has killed others in Medellín and Valle del Cauca Department. Martínez had worked as a farmer, but also held other jobs in surveillance and gardening.

Condemnation
Martínez was sentenced to 42 years imprisonment for the murder of Arango, Gil and her two children. He was charged with several crimes, including forced disappearance and murder.

See also
 List of serial killers in Colombia

References

1972 births
21st-century criminals
Colombian serial killers
Filicides
Living people
Male serial killers
People convicted of murder by Colombia
People from Caldas Department
Uxoricides

redpajama_set_name: RedPajamaWikipedia


text:
Broavo
93 – Host of the new show Your, Mine, or Ours, Taylor Spellman
Host of the new show Your, Mine, or Ours, Taylor Spellman
Today in the lounge I have an amazing interior designer and home stager, Taylor Spellman from New York, that has just launched a television show on Bravo called Yours, Mine, or Ours.
Get to know Taylor Spellman from New York (4:06)
Taylor is currently in SoHo. She loves a heavy-bodied red wine, her bedroom because sleep is scarce, and her family's annual tradition of vacationing to Rhode Island.
How did Taylor get into interior design? (10:10)
Taylor has not had any formal training or education within the interior design field, but rather attended Fordham University for dance. She then moved to New York to continue dancing, but soon realized a disconnect between the lifestyles of the people around her – great jobs, nice restaurants, a tasteful wardrobe, but they go home to a nightmare apartment and drink wine out of plastic cups!
She turned this observation into a business that took off. She catered her interior design business to single men to start, but in time women and families showed interest. Taylor fondly remembers her first client, Sal, from nine years ago, who showed proof of concept for what some thought was a far-fetched idea.
What does Taylor's business look like today? (14:30)
While the bachelor focus was a great launch-pad and competitive advantage, the business has been rebranded as Taylor Spellman New York. Taylor's seven person firm focuses on high-end residential design as well as staging too.
Taylor saw staging as an opportunity due to lack of competition in the market, with just one other prominent company. Like interior design, the is a self-trained stager. She had the opportunity to stage one of Ryan Serhant's listings,which had been on the market for years. After Taylor's staging, there was a bidding war and now she works with Ryan regularly.
Being on TV (19:15)
Taylor's show Yours, Mine, or Ours launched this week. It's a 10 episode series that's both funny and kind. In each episode Taylor and Reza Farahan (from Shahs of Sunset) meet with a couple who each have their own homes. Taylor resolves the design issues in their current homes, while Reza shows the couple two new homes. In the end, the couple must choose between these four options.
The Taylor Touch (25:16)
As Taylor's company grows, she has had to be less hands on, which she mentioned is good, but challenging. She is learning to delegate and oversee. Taylor is still involved with initial meetings and consultations, but then hands projects off to her team for execution. She is able to keep things moving forward, and then provide some finishing touches – The Taylor Touch.
Taylor also mentioned that she is present on all home staging projects. Her goal is to maximize the price per square foot, not just provide a beige couch and a taupe rug. She wants to make everyone feel at home instantly.
How did Taylor learn to do this if she didn't go to school? (32:00)
Taylor Spellman has always loved interior design. She decided to do what she thought was right for her and make it work. To some degree, it is innate and instinctual. In the beginning she received feedback about not having a portfolio, education, or ASID behind her name, but didn't let that stop her.
As of Monday, Taylor got what she wanted. Her company is up and running. She is helping others turn their home into the sacred space they need. And her TV show is launching. She is sleeping better than ever, until the next challenge arises!
Business and beyond (37:02)
It has taken Taylor ten years to get to this point. She now feels comfortable taking interviews. She has her point of view on design. In order to get her business to this point, Taylor has had to put processes in place and make the company scalable. She is moving into the lifestyle market with flower arrangements and table scapes and hopes to be the next modern day Martha Stewart!
If you would like to connect with Taylor Spellman, please visit taylorspellman.com and check out Yours, Mine, or Ours Monday nights on Bravo at 10/9C

redpajama_set_name: RedPajamaCommonCrawl


text:
The Mindy Project: While I Was Sleeping
September 16, 2015 12:01 PM - Season 4, Episode 1 - Subscribe
In which Mindy experiences a parallel universe.
Disregarding the implausibility of Danny and Morgan travelling to India and back in what seemed to be a single day, this was a delight. A couple of lovely cameos from Joseph Gordon-Levitt and Kunal Nayyar, and a final scene that made me cry.
posted by essexjan (7 comments total)
I discovered by surprise that Mindy was back. Thankfully, there's no discernible drop in the quality of the show and watching Danny suffer Boston love because he was burdened with guilt was a delight. Morgan a failed recruiting attempt for the Taliban was great, "I could go blow up a bus! No, wait...."
The It's a Wonderful Life But In Color and Not Boring for Mindy was entertaining, but definitely felt a little forced. I don't think Mindy really needed to have some kind of life changing experience to make her want to be with Danny, with or without a marriage.
posted by Atreides at 2:20 PM on September 16, 2015
Just finished watching, loved it, so happy that Hulu picked it up! I felt that it was an improvement over the network version. Production values, editing, shooting all looked better. VERY funny and tight - I tried not to laugh out loud because I would miss the next joke.
Up to a point, I don't care much if the plots are contrived (and they certainly were here). I just want to watch Mindy Kaling do her comedy. For me, all they need is a frame to hang jokes on, and please god not too much drama and soapy bs. (I admit that Chris Messina is able to make me cry, though, too.)
I liked the Boston bit, too. Also, when Joseph Gordon-Levitt appeared, I said, "Too bad she couldn't get Michael Fassbender," and then there was a Michael Fassbender joke. Ha!
posted by hiker U. at 6:54 PM on September 16, 2015 [3 favorites]
It felt like the episode was slightly longer than usual (without commercials); if it was, it showed. On Fox, it was too jam packed with stuff whereas this episode felt like it had room to breathe (even though I agree it was was very tight and I know I missed jokes from laughing).
Mindy's parents were perfect and, as a long time fan of Mindy's brother who has been waiting for more of her family, worth the wait.
posted by MCMikeNamara at 8:00 AM on September 17, 2015
I completely agree about Mindy's parents, I don't think they could have been written any better to make one understand and appreciate who Mindy and her brother are today. It was well cast and well written.
posted by Atreides at 8:23 AM on September 17, 2015
I really enjoyed the episode. Something about the A plot being a dream and the B plot being real but still cutting back and forth between them as though they're happening simultaneously was weirdly appealing to me.
I loved Mindy's parents.
posted by doctornecessiter at 8:47 AM on September 17, 2015
This was a great episode of television. I'm so glad it got picked up by Hulu, it might be my favorite show.
posted by phunniemee at 5:12 PM on September 21, 2015
Mindy's parents were indeed perfect and non-stereotypical (we didn't need a stereotypical conflict here), which is underlined by how little Danny and Morgan know about anything to do with India (including how long it takes to get there and back, unless Mindy slept for a scarily long time, or we can just assume dream logic). It makes total sense why Mindy is such a believer in love, and it's great to see her parents' love of and support for her (honestly, we need more "supportive parents" on TV, but maybe that's because I watch too many shows by Joss Whedon).
I'm getting a little sick of "Danny is a dick, comes around" plots, but they really sold this one. The little hitch in his voice when he says "I want to believe" at the end of the proposal made my heart happy in a way that had really been lacking through a lot of the last season, which is why TMP had gone from "I need to watch this awesome show, which I love, immediately" in season two to feeling my heart sink until I was almost completely blank about it. I have hope again. I want to believe.
Enjoyed JGL in this, and it was interesting to see the "Mindy indulges herself without Danny" subplot, but yeah, they don't both need epiphanies, because she already knows what she wants. Brendon Deslaurier is so damn creepy when he smells her hair, and the scene between Mindy and the Danny who hasn't talked to her in two years was surprisingly upsetting. It's nice to revisit the scene on the plane, and the "why didn't you just kiss me" scene in the rain was well done.
"Men who dance after 30 just look foolish"
posted by ilana at 2:34 PM on September 28, 2015
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themindyproject


I recently had the opportunity to visit Vancouver, British Columbia for work and I was looking forward to it since I haven't been there since I was about 14 years old. I must say, although I didn't get to sight see a great deal, Vancouver exceeded my expectations.
Vancouver is a thriving multi-cultural community situated between a breathtaking mountain range and the beautiful waters of the Pacific Ocean.
The city appears to have invested a lot of money and effort into developing its harbour and shoreline trails. As a former roller derby player I was envious of the miles of smooth pathways and wished I had brought along my roller skates to get some exercise and take full advantage of these wonderful trails. Without my skates I had to settle for a leisurely 10 km jog around the scenic Stanley Park. I say leisurely because there were many photo stops along the way to photograph the natural beauty of the area as well as cherry and apply blossoms which were in bloom while I was there.
Not far from my hotel, the Hyatt, was the 2010 Olympic Cauldron which was considerably less magnificent than I had remembered from watching all the television footage of the event. In its defence however, I did not get to see it lit up and there was a barrier around it to the mar the visual effect.
One item that was as good as the hype from the Olympics was the Japadog food truck. A juicy hotdog with traditionally Japanese toppings like seaweed and wasabi sauce may sound odd together but came together in a surprisingly tasty meal. I completely understand why they were in such demand during the Olympics.
As with most conferences I attend I seem to eat my way through them and the conference in Vancouver was no exception. I can't even remember how many mouth-watering salmon dishes I gorged myself on, especially sushi.
One of my favorite meals was at the Cactus Club across the street from the Hyatt. I had the butternut squash ravioli with truffle butter sauce and jumbo prawns for an appetizer and the raincoast greens salad as my main. Everything was so fresh and tasty and the Bellini and their Signature Sangria weren't too bad either.
They Hyatt itself is a newer tastefully decorated hotel with the most attentive and helpful concierge staff I have had the pleasure to deal with in recent years. Not only did they provide maps, directions, suggestions and arrange multiple tours and transportation for our diverse group. They also (without us asking them to) called around to confirm attractions we wanted to see would be open and thankfully too, since the Dr. Sun Yat-Sen Chinese Garden was not open on the day we wanted to visit.
My one minor complaint with the Hyatt was the new elevator system that could not keep up with the extremely large volume of guests that wanted to use the elevators all at the same time when the sessions let out. I took more than one elevator trip with a repair technician as he tested the system but I was comforted by the fact that they were actively trying to correct the problems.
One of the tours that the concierge suggested was a free tour and I love free. Tour guys operate in a number of larger centers and their guides work strictly on tips. Emma (I believe her name was) was our guide for the morning, leading us around the downtown core telling us about some of the more interesting buildings, like the Marine Building and Christ Church Cathedral. She also pointed out some of the many art pieces, like "The Pendulum" and "The Drop".
I found it commendable that in the current climate of cutbacks for the arts Vancouver has implemented a policy whereby for every square foot of new private sector re-zoned space built in the downtown core the builder is required to contribute $1.81/per sq. ft. to a public arts process. These art projects have certainly lent themselves to the beautification of the area and created more interesting items for tourists (like me) to admire.
As I said at the start of this post Vancouver exceeded my expectations and I can't wait to return.


text:
anthropology-group-journalslipid-metabolism-disorderIntracellular ProteinsInternational Retailing Cell Replacement Therapy for Diabetes Top Journalsfinancial-affairs-group-journalsEnvironmental Forensics and chemical fingerprinting Peer-review Journalschild birthDNA microarrays journals Bone Marrow Aspirate JournalsHaematopoiesis Open Access JournalsAuditingcancer cell top open access journalsInsect Biodemographytumorigenicity
Open Access Articles- Top Results for Imidazole
Advanced Techniques in Biology & Medicine
Double β-alanine Substitutions Incorporated in 12-ring Pyrrole-Imidazole Polyamides for Lengthened DNA Minor Groove Recognition
Research & Reviews: Journal of Medicinal & Organic Chemistry
Synthesis, Characterization and Antimicrobial Evaluation of Novel Organo Phospho Carbamates Containing Imidazole Ureas/Carboxamides
Biomolecular Research & Therapeutics
Electrochemical Sensor Based on 2-Benzimidazolethiole Modified Carbon Paste Electrode for Lead Chelation Therapy
Journal of Pharmaceutical Research and Clinical Practice
Insilico Design, Synthesis and In vitro Antidiabetic and Anti- Inflammatory Activities of 1,3,4-Thiadiazole Substituted 2-Methyl Benzimidazole Deriv
Pharmaceutica Analytica Acta
Structural Elucidation of Sulfur Derivatives of Benzimidazoles by Density Functional Calculations, and Vibrational and NMR Spectral Analyses
#REDIRECTmw:Help:Magic words#Other
This page is a soft redirect. colspan=2 class="borderless" border=0 align=center #REDIRECTmw:Help:Magic words#Other
This page is a soft redirect.
Full structural formula
Skeletal formula with numbers
This page is a soft redirect.- #REDIRECTmw:Help:Magic words#Other
Ball-and-stick model
Space-filling model
This page is a soft redirect.-
colspan=2 style="background:#f8eaba; border-top:2px solid transparent; border-bottom:2px solid transparent; text-align:center;" #REDIRECTmw:Help:Magic words#Other
This page is a soft redirect. Names
1H-Imidazole
1,3-diazole
glyoxaline (archaic)
1,3-diazacyclopenta-2,4-diene
This page is a soft redirect. Identifiers#REDIRECTmw:Help:Magic words#Other
288-32-4 7pxY
ChEBI CHEBI:16069 7pxY
ChEMBL ChEMBL540 7pxY
ChemSpider 773 7pxY
InChI=1S/C3H4N2/c1-2-5-3-4-1/h1-3H,(H,4,5) 7pxY
Key: RAXXELZNTBOGNW-UHFFFAOYSA-N 7pxY
InChI=1/C3H4N2/c1-2-5-3-4-1/h1-3H,(H,4,5)
Key: RAXXELZNTBOGNW-UHFFFAOYAS
Jmol-3D images Image
KEGG C01589 7pxY
PubChem Template:Chembox PubChem/format
RTECS number NI3325000
Template:Chembox SMILES/format
This page is a soft redirect. Properties
C3H4N2
Molar mass 68.077 g/mol
Appearance white or pale yellow solid
Density 1.23 g/cm3, solid
Melting point Script error: No such module "convert".
Boiling point Script error: No such module "convert".
Acidity (pKa) 14.5 (for imidazole) and 7.05 (for the conjugate acid) [1]
UV-vis (λmax) 280 nm
This page is a soft redirect. Structure
Crystal structure monoclinic
planar 5-membered ring
Dipole moment 3.61D
This page is a soft redirect. Hazards
SDS External MSDS
Main hazards Corrosive
R-phrases R20 R22 R34 R41
S-phrases S26 S36 S37 S39 S45
Flash point Script error: No such module "convert".
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
14pxY verify (what is: 10pxY/10pxN?)
Infobox references
Imidazole is an organic compound with the formula (CH)2N(NH)CH. It is a colourless solid that dissolves in water to give mildly alkaline solution. In chemistry, it is an aromatic heterocycle, classified as a diazole and as an alkaloid.
Derivatives of imidazole, called imidazoles, form a common family of heterocycles that share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building-blocks, such as histidine, and the related hormone histamine. Many drugs contain an imidazole ring, such as antifungal drugs, nitroimidazole, and the sedative midazolam.[2][3][4][5][6]
When fused to a pyrimidine ring, it forms purine, which is the most widely occurring nitrogen-containing heterocycle in nature.[7]
1 Structure and properties
1.1 Amphoterism
2 Preparation
3 Biological significance and applications
3.1 Pharmaceutical derivatives
4 Industrial applications
5 Salts of imidazole
6 Related heterocycles
Structure and properties
Imidazole is a planar 5-membered ring. It exists in two equivalent tautomeric forms, because the proton can be located on either of the two nitrogen atoms. Imidazole is a highly polar compound, as evidenced by a calculated dipole of 3.61D. It is highly soluble in water. The compound is classified as aromatic due to the presence of a sextet of π-electrons, consisting of a pair of electrons from the protonated nitrogen atom and one from each of the remaining four atoms of the ring. Some resonance structures of imidazole are shown below:
Amphoterism
Imidazole is amphoteric. That is, it can function as both an acid and as a base. As an acid, the pKa of imidazole is 14.5, making it less acidic than carboxylic acids, phenols, and imides, but slightly more acidic than alcohols. The acidic proton is located on N-1. As a base, the pKa of the conjugate acid (cited above as pKBH+ to avoid confusion between the two) is approximately 7, making imidazole approximately sixty times more basic than pyridine. The basic site is N-3. Protonation gives the imidazolium cation, which is symmetrical.
Imidazole was first reported in 1858, although various imidazole derivatives had been discovered as early as the 1840s. Its synthesis, as shown below, used glyoxal and formaldehyde in ammonia to form imidazole (or glyoxaline, as it was originally named).[8] This synthesis, while producing relatively low yields, is still used for creating C-substituted imidazoles.
In one microwave modification, the reactants are benzil, benzaldehyde and ammonia in glacial acetic acid, forming 2,4,5-triphenylimidazole (Lophine).[9]
Imidazole can be synthesized by numerous methods besides the Debus method. Many of these syntheses can also be applied to different substituted imidazoles and imidazole derivatives by varying the functional groups on the reactants. These methods are commonly categorized by which and how many bonds form to make the imidazole rings. For example, the Debus method forms the (1,2), (3,4), and (1,5) bonds in imidazole, using each reactant as a fragment of the ring, and thus this method would be a three-bond-forming synthesis. A small sampling of these methods is presented below.
Formation of one bond
The (1,5) or (3,4) bond can be formed by the reaction of an imidate and an α-aminoaldehyde or α-aminoacetal, resulting in the cyclization of an amidine to imidazole. The example below applies to imidazole when R=R1=Hydrogen.
Formation of two bonds
The (1,2) and (2,3) bonds can be formed by treating a 1,2-diaminoalkane, at high temperatures, with an alcohol, aldehyde, or carboxylic acid. A dehydrogenating catalyst, such as platinum on alumina, is required.
The (1,2) and (3,4) bonds can also be formed from N-substituted α-aminoketones and formamide with heat. The product will be a 1,4-disubstituted imidazole, but here since R=R1=Hydrogen, imidazole itself is the product. The yield of this reaction is moderate, but it seems to be the most effective method of making the 1,4 substitution.
Formation of three bonds
Formation of four bonds
This is a general method that is able to give good yields for substituted imidazoles. In essence, it is an adaptation of the Debus method called the Debus-Radziszewski imidazole synthesis. The starting materials are substituted glyoxal, aldehyde, amine, and ammonia or an ammonium salt.[10]
Arduengo imidazoles
Formation from other heterocycles
Imidazole can be synthesized by the photolysis of 1-vinyltetrazole. This reaction will give substantial yields only if the 1-vinyltetrazole is made efficiently from an organotin compound, such as 2-tributylstannyltetrazole. The reaction, shown below, produces imidazole when R=R1=R2=Hydrogen.
File:Ringformation.svg
Imidazole can also be formed in a vapor-phase reaction. The reaction occurs with formamide, ethylenediamine, and hydrogen over platinum on alumina, and it must take place between 340 and 480 °C. This forms a very pure imidazole product.
Van Leusen reaction
The Van Leusen reaction can also be employed to form imidazoles starting from TosMIC and an aldimine.
Biological significance and applications
Imidazole is incorporated into many important biological molecules. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes and plays a vital part in the structure and binding functions of hemoglobin. Imidazole-based histidine compounds play a very important role in intracellular buffering.[11] Histidine can be decarboxylated to histamine, which is also a common biological compound. It is a component of the toxin that causes urticaria, which is another name for allergic hives. The relationship between histidine and histamine are shown below:
File:Histidine decarboxylase.svg
One of the applications of imidazole is in the purification of His-tagged proteins in immobilised metal affinity chromatography (IMAC). Imidazole is used to elute tagged proteins bound to Ni ions attached to the surface of beads in the chromatography column. An excess of imidazole is passed through the column, which displaces the His-tag from nickel co-ordination, freeing the His-tagged proteins.
Imidazole has become an important part of many pharmaceuticals. Synthetic imidazoles are present in many fungicides and antifungal, antiprotozoal, and antihypertensive medications. Imidazole is part of the theophylline molecule, found in tea leaves and coffee beans, that stimulates the central nervous system. It is present in the anticancer medication mercaptopurine, which combats leukemia by interfering with DNA activities.
A number of substituted imidazoles, including clotrimazole, are selective inhibitors of nitric oxide synthase, which makes them interesting drug targets in inflammation, neurodegenerative diseases and tumors of the nervous system.[12][13] Other biological activities of the imidazole pharmacophore relate to the downregulation of intracellular Ca++ and K+ fluxes, and interference with translation initiation.[14]
Pharmaceutical derivatives
The substituted imidazole derivatives are valuable in treatment of many systemic fungal infections.[15] Imidazoles belong to the class of azole antifungals, which includes ketoconazole, miconazole, and clotrimazole.
For comparison, another group of azoles is the triazoles, which includes fluconazole, itraconazole, and voriconazole. The difference between the imidazoles and the triazoles involves the mechanism of inhibition of the cytochrome P450 enzyme. The N3 of the imidazole compound binds to the heme iron atom of ferric cytochrome P450, whereas the N4 of the triazoles bind to the heme group. The triazoles have been shown to have a higher specificity for the cytochrome P450 than imidazoles, thereby making them more potent than the imidazoles.[16]
Imidazole has been used extensively as a corrosion inhibitor on certain transition metals, such as copper. Preventing copper corrosion is important, especially in aqueous systems, where the conductivity of the copper decreases due to corrosion.
Many compounds of industrial and technological importance contain imidazole derivatives. The thermostable polybenzimidazole PBI contains imidazole fused to a benzene ring and linked to a benzene, and acts as a fire retardant. Imidazole can also be found in various compounds that are used for photography and electronics.
Simple imidazolium cation
Salts of imidazole
Salts of imidazole where the imidazole ring is in the cation are known as imidazolium salts (for example, imidazolium chloride). These salts are formed from the protonation or substitution at nitrogen of imidazole. These salts have been used as ionic liquids and precursors to stable carbenes. Salts where a deprotonated imidazole is an anion are also possible; these salts are known as imidazolide or imidazolate salts (for example, sodium imidazolide).
Related heterocycles
Benzimidazole, an analog with a fused benzene ring
Dihydroimidazole or imidazoline, an analog where 4,5-double bond is saturated
Pyrrole, an analog with only one nitrogen atom in position 1
Oxazole, an analog with the nitrogen atom in position 1 replaced by oxygen
Thiazole, an analog with the nitrogen atom in position 1 replaced by sulfur
Pyrazole, an analog with two adjacent nitrogen atoms
Triazoles, analogs with three nitrogen atoms
1-Methylimidazole
^ Walba, H. & Isensee, R. W. Acidity constants of some arylimidazoles and their cations. J. Org. Chem. 26, 2789-2791 (1961).
^ Alan R. Katritzky; Rees. Comprehensive Heterocyclic Chemistry. Vol. 5, p.469-498, (1984).
^ Grimmett, M. Ross. Imidazole and Benzimidazole Synthesis. Academic Press, (1997).
^ Brown, E.G. Ring Nitrogen and Key Biomolecules. Kluwer Academic Press, (1998).
^ Pozharskii, A.F, et al. Heterocycles in Life and Society. John Wiley & Sons, (1997).
^ Heterocyclic Chemistry TL Gilchrist, The Bath press 1985 ISBN 0-582-01421-2
^ Rosemeyer, H (2004). Chemistry & Biodiversity 1: 361. doi:10.1002/cbdv.200490033. Missing or empty |title= (help)
^ Heinrich Debus (1858). "Ueber die Einwirkung des Ammoniaks auf Glyoxal". Annalen der Chemie und Pharmacie 107 (2): 199–208. doi:10.1002/jlac.18581070209.
^ Microwave-Mediated Synthesis of Lophine: Developing a Mechanism To Explain a Product Crouch, R. David; Howard, Jessica L.; Zile, Jennifer L.; Barker, Kathryn H. J. Chem. Educ. 2006 83 1658
^ US patent 6,177,575, A. J. Arduengo, "Process for Manufacture of Imidazoles", issued 2001-01-23
^ Hochachka, P.W. & G.N. Somero, 2002. Biochemical adaptation: mechanisms and process in physiological evolution. New York: Oxford University Press. 466 p.
^ Castaño T, Encinas A, Pérez C, Castro A, Campillo NE, Gil C. (2008). "Design, synthesis, and evaluation of potential inhibitors of nitric oxide synthase."Bioorg Med Chem. 16 (11) : 6193-206. PMID 18477512
^ Bogle RG, Whitley GS, Soo SC, Johnstone AP, Vallance P. (1994). "Effect of anti-fungal imidazoles on mRNA levels and enzyme activity of inducible nitric oxide synthase". Br J Pharmacol. 111 (4) : 1257-61. PMC1910171
^ Khalid MH, Tokunaga Y, Caputy AJ, Walters E. (2005)."Inhibition of tumor growth and prolonged survival of rats with intracranial gliomas following administration of clotrimazole." J Neurosurg. 103 (1) : 79-86. PMID 16121977
^ Leon Shargel. Comprehensive Pharmacy Review (6th ed.). p. 930.
^ Riviere and Papich. Veterinary Pharmacology and Therapeutics (9th ed.). pp. 1019–1020.
Antifungals (D01 and J02)
Wall/
Ergosterol
Azoles
(lanosterol 14
alpha-demethylase inhibitors)
Topical: bifonazole
chlormidazole
clotrimazole#, croconazole
econazole
isoconazole
miconazole#, neticonazole
omoconazole
oxiconazole
sertaconazole
Topical: (fluconazole#, fosfluconazole
terconazole)
Systemic: (fluconazole
isavuconazole†, itraconazole
voriconazole)
Unknown: (albaconazole)
Topical: (abafungin)
Polyene antimycotics
(ergosterol binding)
Topical: (hamycin
nystatin#)
Systemic: (amphotericin B#, hamycin)
Allylamines
(squalene monooxygenase
inhibitors)
Topical: (amorolfine
butenafine
naftifine
terbinafine)
Systemic: terbinafine
β-glucan synthase
echinocandins (anidulafungin
micafungin)
Intracellular
Pyrimidine analogues/
thymidylate synthase inhibitors
flucytosine#
Mitotic inhibitors
griseofulvin#
Aminoacyl tRNA synthetase inhibitors
bromochlorosalicylanilide
methylrosaniline
tribromometacresol
polynoxylin
chlorophetanol
ticlatone
sulbentine
haloprogin
selenium disulfide#
amorolfine
dimazole
tolciclate
sodium thiosulfate#
Whitfield's ointment#
potassium iodide#
lemon myrtle
PCP: pentamidine
Index of fungal disease
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The microturbine maker hit record revenue and gross profit in its third quarter, so why are investors worried?
Capstone Turbine's (NASDAQ:CPST) third-quarter numbers missed Street estimates, and that hasn't gone down well with the market -- the stock's down about 6% this morning. But considering that the microturbine maker hit new highs on its top line as well as gross profit, why is the market getting fidgety? Maybe investors need to dig deeper into the earnings report.
Capstone appears to have done a decent job during the third quarter. Here's a quick recap of the key performance metrics.
Capstone's revenue jumped 11% year over year to $37 million, which was a record for the company.
Gross margin expanded an astounding six percentage points to 20%, both sequentially and year over year, to hit record high.
Capstone halved its losses to $2.2 million year over year. But net loss per share was flat at $0.01 since the company repurchased shares under expired warrants in Q3 this year which increased its outstanding share count.
That pretty much sums up Capstone's third-quarter performance, and it looks good to me. The losses shouldn't have freaked the market out, because Capstone may still have some more quarters before it can turn profitable. But while above metrics give you an overview of things, they don't tell you the full story. To know whether the company is moving in the right direction or not, you need to know the following numbers.
Capstone's third-quarter-backlog value improved 7% year over year to $160.4 million, indicating a growing order book.
A book-to-bill ratio of 1.4 means that the company booked orders worth $140 for every $100 worth of orders fulfilled and billed during the quarter. Total order value was $40.5 million for the quarter, up 87% year over year. But, the company received orders for only 109 microturbines during the third quarter, compared to 137 units in Q3 2012.
So what does that mean? It looks like Capstone's sales volumes aren't growing, and the product mix is boosting the company's revenue. In other words, Capstone is selling more higher-wattage microturbines like C65 and C1000 (which are, of course, priced at a premium compared to lower-wattage machines) even as sales for its smaller machines are slowing down.
That's actually favorable from the profitability angle, since the company can generate higher margins even on low volumes. That's evident from the fact that Capstone's average revenue per machine rose 16% to $184,000 year over year during the third quarter despite a drop in the number of units shipped.
Going forward, Capstone expects to break even on its operating earnings or earnings before interest, taxes, depreciation, and amortization (EBITDA) by the next quarter. Considering that the company needs roughly $40 million in revenue and gross margin of about 21.5% to break even, it looks feasible, which is great news for investors.
Capstone started 2014 on a solid note, judging by the number of orders it received in January. The lucrative and high-potential oil and gas market continued to be its largest and fastest-growing market, accounting for 59% of its total shipments during the quarter. So it looks like the company's top line should continue to grow at an accelerating pace, which should help it reverse losses and turn cash flow positive over the next few quarters.
More notably, Capstone wants to hit a gross margin of 35% over the next two years. The good news is that management expects most of it to be driven by cost reductions, and not higher selling prices. Whether the company will achieve the target or not is anyone's guess, but management seems to have some plans up its sleeves and sounds confident. And that sounds like a good reason to keep an eye on this company.
Editor's Note: Article previously included a section telling investors to pay attention to slowing orders of C200 turbines. Since the company now packages five C200's in a C1000, the logic was incorrect because more C200's are being sold, just not on an individual basis. The Motley Fool apologizes and regrets this error.


Located in Santa Cruz de Tenerife, near Tenerife Espacio de las Artes, Heliodoro Rodriguez Lopez Stadium and Museo municipal de Bellas Artes, Casa Kilig features free WiFi.
Museo militar regional de Canarias is 5.5 km from Casa Kilig, while Auditorio de Tenerife is one kilometer from the property. Tenerife Norte Airport is 9.7 km away.
This is our guests' favorite part of Santa Cruz de Tenerife, according to independent reviews.


2019 Honda Ridgeline Vcm Specs, Interior, Changes, Interior – 2019 honda ridgeline vcm, . A full and diverse car model is what the after that technology of 2019 Honda Ridgeline pledges. There are different rumors that Honda is seeking to arrive up with a new concept of the car's body and are looking to produce a standard body on the body creating.
This might let them consider a directly the Tacoma and additional on the pickups trucks on the market. This car review is supposed to maintain our serious car visitors current on the new truck arrivals.
What Will The 2019 honda ridgeline vcm Changes Look Like?
In terms of the exterior of the 2019 Honda Ridgeline you will see various changes to the car which is from my spy photos. The new image of the new model with its well balanced and wealthy components will really update the voyage research. Gossip has it that the new Honda Ridgeline can have softer street performance which is since it will likely be heightened by with a superb shut down box single body platform.
It include four doors together with a very little long roof top. Customers of the truck do not need to to be concerned as you will find huge cargo room and a huge trailers for carrying heavy components and relationships for crucial add-ons as nicely as digital instruments. The front side component of the new Honda Ridgeline may have an arresting rectangle grille with the add-on of chrome clip. The front side include will slip lower from its hood by way of its fender to the base of the truck. Higher quality front lights are anticipated as well as includes LED lighting. The new truck is also supposed to have new tires repaired with really appealing car tires that can match all form s of highways.
The on the inside of the 2019 Honda Ridgeline has not yet been through significantly changes in comparison with its outdoors. The inside of will certainly be produced with higher quality components. The interior cabin of the new Honda Ridgeline is created in this kind of a way that it may very easily hold a lowest of five passengers. Engineering improvements are also envisioned which consists of: progressive screen on the trucks middle gaming console, menu, a new ac as effectively as infotainment amongst other desirable features.
At the leading of its class in performance and dealing with, the Ridgeline's V6 engine delivers clean velocity and couples beautifully with the clean-switching six-speed automatic, when the crossover-centered chassis carves sides a lot more like a car. Abnormal street areas are managed with aplomb (better yet than the Pilot) with very much of the credit history because of a middle bed furniture encouragement, as properly as hydraulic suspensions bushings, double-activity dampers, and, on AWD models, a rear torque-vectoring system. Payload capability – which shirts out at 1,569 weight – is in line with Chevy's body-on-framework Colorado.
The Ridgeline's unibody design and shortage of reduced-range gearing also ensure it is a significantly less-than-ideal away from-roader. The litany of transgressions includes an acceptable 7.9 ins of terrain clearance that's lessened to 6 " under the rear management biceps and triceps, and a shortfall in torque in comparison to the Canyon/Colorado, causing a 5,000-lb towing capacity that's 2,000 brief of GM's twins. The Rideline also is lacking in mountain descent manage, when its technique and leaving aspects can't match up all those of its competitor's off-road editions.
When Does 2019 honda ridgeline vcm Come Out?
How Much Is 2019 honda ridgeline vcm Price?
The price of the Honda Ridgeline is predicted to get from some thing among 38,000 $ $ $ $ to 42,000 bucks.
What Is New For 2019 Honda Ridgeline ?


text:
CANON BROOK TRAIL and A. MURRAY YOUNG PATH
There are so many interesting hiking routes to the top of Cadillac Mountain that it may be hard to keep track of them all and choose which one(s) to hike. Aside from the popular Cadillac South Ridge Trail, the Cadillac North Ridge Trail, the Gorge Path, and the Cadillac West Face Trail, there are also a few connector trails that are worthy of exploration, including Canon Brook Trail, the A. Murray Young Path, and the Bubble-and-Jordan-Ponds Path. These remote sections of trail traverse around the south side of Cadillac Mountain to hit a few off-the-beaten-path viewpoints and can be included in longer loop hikes through the park.
Canon Brook Trail (2 miles one way):
The Canon Brook Trail starts at a roadside parking area along Route 3 roughly one mile south of the Sieur de Monts Entrance. From the trailhead, hike west to cross the small marshy ponds to the first trail junction. The Kane Path heads north to the Tarn (pond), but we'll head south along the forested Canon Brook Trail as it circles clockwise around the south side of Dorr Mountain to pass the junction with the Dorr South Ridge Trail. (This whole section of trail used to be known as the "Tarn Trail.") At the next junction with the A. Murray Young Path, the trail joins up with Canon Brook and starts a fairly steep ascent up the south ridge of Cadillac Mountain.
The highlight of this hike is a beautiful open section of rock where the brook trickles through an impressive crevasse cut out of the granite mountain. The trail goes up and around to the left/south side of the notch, offering a great view of Dorr and Champlain Mountain to the northeast. The trail then continues its ascent to the west and soon enough, we are at the junction with the Cadillac South Ridge Trail by the picturesque Featherbed (pond). Head north up the South Ridge Trail to the summit of Cadillac Mountain or head west along the Bubble-and-Jordan-Ponds Path to descend another beautiful remote section of trail.
A. Murray Young Path (1.2 miles one way):
This memorial path named for Andrew Murray Young (an early fan of the island) connects the Canon Brook Trail with the Gorge Trail and follows the gorge between Cadillac Mountain and Dorr Mountain south of the saddle between the two peaks. The lower forested section of the trail follows the gorge's small stream and ascends to the upper section where the well-engineered path navigates the boulder-choked gorge. At the saddle is the trail junction where you can take the Gorge Path west another .4 miles to the summit of Cadillac Mountain or the short but steep trail east to the summit of Dorr Mountain.
Bubble-and-Jordan-Ponds Trail (1.1 miles one way):
The Bubble-and-Jordan-Ponds Trail acts as a connector between Jordan Pond and the Cadillac South Ridge Trail. The total trail length from its start at the southeast corner of Jordan Pond to the junction with the Cadillac South Ridge Trail is 2.2 miles, but the most interesting section of this trail, east of the Bubble Pond carriage road ascending the Cadillac south ridge to the junction at the Featherbed (pond), is 1.1 miles. Heading east from the carriage road junction, the Bubble-and-Jordan-Ponds Trail leaves the forested marsh near Bubble Pond and ascends an interesting section of the mountain with several picturesque viewpoints. Iron handrails help in a few spots, but this fairly strenuous section of trail isn't as precarious as the Cadillac West Face Trail. Soon enough you top out at the Featherbed and the junction with the Cadillac South Ridge Trail.
Joe's Spin:
I lumped these three remote trails into one description because they are all interconnected and several golden spots make them all worthy of exploration. Due to their somewhat remote locations, they do not make for short and simple hikes, so they must be included in a longer loop hike up and around Cadillac Mountain and/or Dorr Mountain.
VIEW THE PHOTOGRAPHS! Return to the Middle Peaks


Remember Nonna's home-baked cookies? Cookie Jough makes the dough like she made, using old family recipes with the finest ingredient, so you can make cookies that bring back memories of your childhood.
With Cookie Jough, the dough arrives frozen and you bake them fresh! We make the mess so you can bake wonderful family memories!
Cookies are a wonderful treat and the smell of fresh baked cookies is a warm welcome in any home. Not just everyday cookies, but cookies like your Nonna use to make. Cookie Jough cookies are based on old Italian family recipes that will bring you back to the smells and tastes of your own childhood.
Yes, it takes time to prepare fresh baked cookies, but with Cookie Jough, we take the time to make the cookie dough, using the same ingredients that you would use at home. The dough will arrive frozen so you can bake them fresh! The dough comes complete with everything you will need to make cookies like you remember!
Wouldn't you like to spend quality time as a family and bake the memories you will all treasure for a lifetime!
Interested in ordering Cookie Jough?
We will have prepared dough for six different cookie ready to ship in December (just in time for your Holiday baking).
Snowball Cookies (complete with powdered sugar for coating), buttery-rich nut cookies coated with powdered sugar.
Anginetti Cookies (complete with powdered sugar to make a frosting), otherwise known as Nona Cookies, flavored with citrus and anise and topped with multi-colored sprinkles.
Italian Nougat Cookie, is almost a confection and it is sure to will remind you of the little box of torroni candy you got as a child.
Ricotta Cookie (complete with powdered sugar to make a frosting), these cake-like cookies are brimming with orange and lemon flavor.
Regina Cookie (complete with sesame seeds), not too sweet and coated with sesame seeds. It's as good with a morning cup of coffee as it is with an afternoon glass of Moscato. This is truly the the queen of cookies!


text:
From: Thomson Reuters Foundation
Wenni Zhou/Unsplash
Norway Just Banned Child Marriage and Set an Example for the World
Norway's minimum marriage age is 18, but exceptions can be made for children as young as 16.
By Emma Batha
LONDON, May 22 (Thomson Reuters Foundation) — Norway approved a law banning all child marriage on Tuesday, with campaigners saying it would set an example to others ahead of a global 2030 deadline for eradicating the practice.
The Nordic country has a minimum age of 18, but allows 16- and 17-year-olds to marry with parental consent and permission from the county governor. A government spokeswoman said very few under 18s had sought to wed in recent years.
"We believe ... this law will send a clear message, nationally as well as internationally, that we do not accept children getting married in Norway," Minister of Children and Equality Linda Hofstad Helleland said in emailed comments.
Take Action: Stand with Sonita: Tell World Leaders to End Child Marriage
"A marriage should always be based on full, free and informed consent," she told the Thomson Reuters Foundation.
Globally, an estimated 12 million girls are married every year before their 18th birthday — nearly one girl every two seconds, according to global campaign group Girls Not Brides.
The United Nations has said all countries should end child marriage by 2030 under global development goals.
The Norwegian branch of aid agency Plan International, which has led calls to reform the law, said Tuesday's unanimous vote in parliament for a total ban was an important milestone.
"A major reason why the law needs to change is the global perspective," said spokeswoman Siv Meisingseth.
"How can we encourage other countries in the developing world to ban child marriage if we don't have our own house in order?"
Read more: Death Sentence for Sudanese Teen Bride Who Stabbed Her Rapist Sparks Outrage
Meisingseth said the reform, which comes a year after Denmark passed a similar ban, would give Norway one of the strictest laws on child marriage in Europe.
"We really want other countries in Europe to copy this law. This should be the standard," she said.
Child marriage forces girls to drop out of school, limits their opportunities, and traps them in poverty, experts say. It also raises the risk of domestic abuse, rape, and serious childbirth complications.
Parliament will hold another reading of the bill next week, but sources said this was a formality and the law would likely come into force shortly.
The law will also ban Norwegians from marrying abroad if either party is under 18. Meisingseth said there had been cases where girls had been taken overseas to be married off to men in their parents' country of origin.
The maximum penalty for child marriage will be three years' imprisonment.
(Editing by Katy Migiro. Please credit the Thomson Reuters Foundation, the charitable arm of Thomson Reuters, which covers humanitarian news, women's rights, trafficking, corruption and climate change. Visit news.trust.org to see more stories.)
TopicsGender EqualityWomen's RightsChild MarriageNorwayGirls EducationChild BrideForced MarriageChildren's RightsEarly Marriage


text:
{
    // here we define a variable for record keeping
    distances : [],
    // optional function called at the beginning of the simulation
    setupSimulation: function() {
	this.startPos = this.getRobot().getCoreComponent().getRootPosition();
	return true;
    },
/*
    // optional function called after each step of simulation
    afterSimulationStep: function() {
	return true;
    },
*/
    // optional function called at the end of the simulation
    endSimulation: function() {

	// Compute robot ending position from its closest part to the origin
	var minDistance = Number.MAX_VALUE;

	bodyParts = this.getRobot().getBodyParts();
	console.log(bodyParts.length + " body parts");
	for (var i = 0; i < bodyParts.length; i++) {
		var xDiff = (bodyParts[i].getRootPosition().x - this.startPos.x);
		var yDiff = (bodyParts[i].getRootPosition().y - this.startPos.y);
		var dist = Math.sqrt(Math.pow(xDiff,2) + Math.pow(yDiff,2));

		if (dist < minDistance) {
			minDistance = dist;
		}
	}

	this.distances.push(minDistance);
	return true;
    },
    // the one required method... return the fitness!
    // here we return minimum distance travelled across evaluations
    getFitness: function() {
	fitness = this.distances[0];
        for (var i=1; i<this.distances.length; i++) {
		if (this.distances[i] < fitness)
			fitness = this.distances[i];
	}
        return fitness;
    },

}

redpajama_set_name: RedPajamaGithub


text:
Y3K is the beautiful new band put together by Yuri Goloubev.
Take three exceptional musicians, fresh memorable tunes, and you get music and improvisation that's out of this world.
Electronic Press Kit
BAND IMAGE NEEDED HERE
Formed in 2015, Y3K brings together three like-minded world-class talents: Yuri Goloubev on bass, Jason Rebello on piano and Asaf Sirkis on drums. Each of them has been internationally celebrated for years, and together they now form a mesmerising trio. Hailing from Russia, the UK and Israel respectively, they now all reside in England, and find their shared passion for beautiful, quality jazz has found a new life in this band.
Audiences warm to a lethal combination of breathtaking soloing and communal good spirits - you can't help but enjoy yourself.
Jason Rebello: Piano
Born 29 March 1969, London, UK
SInce the age of 19, Jason has been hailed as one of the most gifted pianists ever to come out of the UK.
His work has spanned jazz, funk, rock and hip-hock, from Peter Gabriel and Sting to Joss Stone and Clare Teal. However he plays, wherever he performs, audiences are struck by his fluency and the brilliance of his melodic lines.
In Y3K he has found a trio to match his legendary ability to create and entertain.
Yuri Goloubev: Doublebass
Born 27 July 1972, Moscow, Russia
Yuri is a rare thing - a doublebassist that audiences and critics alike will travel a long way to see.
Trained classically in Moscow, Yuri has performed worldwide since the age of 18, equally at home at the Bolshoi Opera and the Montreaux Jazz Festival. When he shifted into the world of jazz, no-one had heard anything like his lyrical, expressive playing before.
He composes beautiful, memorable tunes for Y3K which take himself, his fellow musicians and his audience into an outer world of expression.
Asaf Sirkis: Drums
Born 22 March 1969, Petah-Tiquah, Israel
Inspired by the diverse culture of his youth, Asaf has a passionate world-view on music, rhythm and culture. His hypnotic playing is flavoured by Europe, the Middle East and North Africa, and brings rock and world music into jazz. He defies genres!
His sensitivity within the jazz trio is what makes him one of the world's premier drummers. And yet he is a drmmer who the audience cannot wait to see solo - he fixes a firm smile onto everyone's face to match his own.
Yuri Goloubev
"Yuri's voice is so distinctive; what he does with his instrument is a unique thing."
Ian Patterson, All About Jazz
"Amazing. His double-bass playing has the fluidity of a fretless electric bass player. Goloubev is set to reach a much wider audience."
Dave Liebman
"Yuri Goloubev is a truly sensational bassist."
Rainlore's World of Music
"The bass player Yuri Goloubev and the drummer Asaf Sirkis generate the most pertinent rhythmical support of exceptional level."
Gerlando Gatto, A Proposito di Jazz
Asaf Sirkis
"He is one of those musicians who, in concert, completely captivates with his confidence, meticulousness and (very clearly) the enjoyment of all he is sharing with colleagues and audience alike."
Adrian Pallant
"Asaf Sirkis sounding creatively freer and more dramatically inventive than ever on drums".
John Fordham, The Guardian
"Sirkis: simply the most sensitive of percussionists"
Chris Parker
''Sirkis is just a joy throughout."
Peter Bacon, Jazz Breakfast
Jason Rebello
"Rebello is possessed of a great pianistic gift."
Chris Parker, The Times
"Even as a teen prodigy, Rebello received praise for his maturity; but now in his forties, having a rich career to draw upon, he's singularly soulful."
Andy Robson, Jazzwise
"For the hard core jazz follower... an excellent reminder of Rebello's abilities as a straight ahead jazz pianist."
Ian Mann, JazzMann
Links to hi-res print-ready images here.
Further information can be found by visiting:
yurigoloubev.com
jasonrebello.co.uk
asafsirkis.co.uk
https://en.wikipedia.org/wiki/Yuri_Goloubev
https://en.wikipedia.org/wiki/Jason_Rebello
https://en.wikipedia.org/wiki/Asaf_Sirkis
Y3K Management
Kathryn Davies
kathryn.e.davies@btinternet.com


text:
Fear of arrest stops some needed calls to 911 after opioid overdose is administered
IMAGE: This is the contents of Naloxone kit. view more
Credit: by IU Communications
INDIANAPOLIS -- Fear of being arrested still undercuts an Indiana law that shields anyone who administers naloxone from criminal charges, according to a survey conducted by two researchers at Indiana University-Purdue University Indianapolis. Naloxone is a lifesaving emergency antidote for opioid overdose.
Approximately 73 percent of survey respondents said 911 was called after naloxone was administered for an overdose, but 27 percent of respondents indicated 911 was not called, according to Dennis Watson, an associate professor in the Indiana University Richard M. Fairbanks School of Public Health, and Bradley Ray, an assistant professor in the IU School of Public and Environmental Affairs, both at IUPUI.
Watson and Ray said their research shows that people don't call 911 because they are afraid of being arrested.
"There is a possibility this fear may translate to death if the naloxone dose provided is not strong enough to completely counteract the opioids in the person's system," Ray and Watson wrote in a recent blog post.
"A person could look perfectly fine, get up and walk away, and then go into overdose again 30 minutes later," Watson said.
Under Aaron's Law, anyone may legally obtain naloxone -- also known by the brand name Narcan -- and administer it. Naloxone can be obtained through a standing order that allows pharmacies to dispense it to the public.
Part of the reason Aaron's Law exists is to make sure people receive the care they need without fear of arrest, Ray said: "This is a public health problem, not a criminal justice problem.
"Naloxone is an incredible, lifesaving substance, and if you use it to save someone's life, you should get a round of applause, not worry about a night in jail," Ray said.
The two IUPUI researchers said additional educational efforts are needed to inform the public about Aaron's Law and naloxone. These efforts should focus on the general public but also be directed at professionals working in this area, they said.
Naloxone is not intended to replace emergency medical care. Persons who administer it are urged to call 911 for medical help.
This survey is part of an evaluation the researchers have conducted of opioid policies that have been implemented in Indiana since 2013. The evaluation is funded by an $800,000 Centers for Disease Control and Prevention grant.
Ray and Watson's team placed survey postcards with the naloxone kits that are handed out at local health departments. Among the questions asked on the postcard, which is mailed back to the researchers, is whether 911 was called after naloxone was administered.
The number of deaths from drug overdoses continues to rise in Marion County. Last year, a record number of people -- 345 -- died from drug overdoses in the county. By comparison, on average, 85 people are killed per year in traffic accidents in Marion County.
As of May 1, there have been 130 drug-overdose deaths in Marion County in 2017, compared to 98 deaths that were recorded at the same time last year.
Ray and Watson received a total of 1,281 cards, including 1,197 that were filled out when the person picked up the kit and 84 that were filled out after the kit was used.
The postcard survey initially targeted 20 counties in Indiana. Another 16 counties were recently added to the survey.
Rich Schneider
rcschnei@iu.edu
@IUScienceNews
http://newsinfo.iu.edu
LAW ENFORCEMENT/JURISPRUDENCE
Naloxone Kit (IMAGE)
https://news.iu.edu/stories/2017/07/iupui/releases/18-naloxone-kits-survey.html
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The Hewlett-Packard Company (commonly referred to as HP) was an American multinational information technology company headquartered in Palo Alto, California. It developed and provided a wide variety of hardware components as well as software and related services to consumers, small- and medium-sized businesses (SMBs) and large enterprises, including customers in the government, health and education sectors.The company was founded in a one-car garage in Palo Alto by William Redington Hewlett and David Packard, and initially produced a line of electronic test equipment. HP was the world's leading PC manufacturer from 2007 to Q2 2013, after which Lenovo came to rank ahead of HP. It specialized in developing and manufacturing computing, data storage, and networking hardware, designing software and delivering services. Major product lines included personal computing devices, enterprise and industry standard servers, related storage devices, networking products, software and a diverse range of printers and other imaging products. HP marketed its products to households, small- to medium-sized businesses and enterprises directly as well as via online distribution, consumer-electronics and office-supply retailers, software partners and major technology vendors. HP also had services and consulting business around its products and partner products.
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text:
Q: Windows scheduled task access NAS as anonymous user I want to create a scheduled task on a computer in my domain. This task should be executed as a specific user, regardless on with user is currently logged in. The task executes a PowerShell script that creates a new folder on a NAS.
(New-Item "path" -Type Directory)
My problem is that the file can not be created, because it does not use the right credentials and therefore the access is denied.
The Event log (on the nas) shows under SMBServer the Username NT-AUTORITÄT\ANONYMOUS-ANMELDUNG.
I would be thankful for any help, and sorry for my mediocre English.
I tried a lot of different approves and found out, that the problem must be in the communication between the client/ad/NAS server. Probably a setting or safety feature that prevents the transfer of the user credentials.


text:
<RelativeLayout xmlns:android="http://schemas.android.com/apk/res/android"
    xmlns:tools="http://schemas.android.com/tools"
    android:layout_width="match_parent"
    android:layout_height="match_parent"
    tools:context="benzm.yugiohlifepointcounter.TimerFragment">

    <TextView
        android:id="@+id/timerPlayer2TextView"
        android:layout_width="wrap_content"
        android:layout_height="wrap_content"
        android:layout_alignParentEnd="true"
        android:layout_alignParentRight="true"
        android:freezesText="true"
        android:text="9:59"
        android:textSize="35sp" />

    <TextView
        android:id="@+id/timerPlayer1TextView"
        android:layout_width="wrap_content"
        android:layout_height="wrap_content"
        android:layout_alignParentBottom="true"
        android:freezesText="true"
        android:gravity="center"
        android:text="7:43"
        android:textSize="35sp" />

    <LinearLayout
        android:layout_width="wrap_content"
        android:layout_height="wrap_content"
        android:layout_centerInParent="true"
        android:orientation="vertical">

        <ImageButton
            android:id="@+id/resetButton"
            android:layout_width="60dp"
            android:layout_height="60dp"
            android:background="?selectableItemBackgroundBorderless"
            android:scaleType="fitCenter"
            android:src="@drawable/ic_refresh_black_128dp" />

        <ImageButton
            android:id="@+id/switchTimer"
            android:layout_width="70dp"
            android:layout_height="70dp"
            android:background="?selectableItemBackgroundBorderless"
            android:scaleType="fitCenter"
            android:src="@drawable/ic_cached_black_128dp" />

        <ImageButton
            android:id="@+id/playPauseButton"
            android:layout_width="60dp"
            android:layout_height="60dp"
            android:background="?selectableItemBackgroundBorderless"
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            android:src="@drawable/ic_play_arrow_black_128dp" />
    </LinearLayout>

</RelativeLayout>


text:
HOME BOOKS FORTHCOMING NEWS & REVIEWS ABOUT CONTACT
Tough Poets Press
Bookshop.org / Barnes & Noble / Amazon
Segelfoss Town
May 24, 2021 / 404 pages
ISBN 9780578882628 Paperback / $16.99
First-ever new edition of J. S. Scott's English translation of Nobel Prize winner Knut Hamsun's novel.
Segelfoss Town (original Norwegian title: Segelfoss By) was first published in 1915 and is an independent continuation of Hamsun's Children of the Age, published two years earlier. The novel is a criticism of modern times, depicting the fall of the landed gentry and the rise of the working class. Segelfoss Town and its predecessor were the first of Hamsun's novels devoted to social issues. The two novels are described by Monika Zagar in Knut Hamsun: The Dark Side of Literary Brilliance (2009) as "much more than dry social analysis; indeed, they investigate, in rich novelistic form, the propagation and survival of a family."
The English translation of the novel was published by Alfred A. Knopf, Inc., in 1925. Unlike most of Hamsun's other novels that were released in the U.S. shortly after he won the Nobel Prize for Literature in 1920, the English version of Segelfoss Town has never been reissued.
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Copyright © 2015–2022 by Rick Schober d/b/a Tough Poets Press


text:
Q: Use synonyms in elasticsearch I am trying to implement synonyms file in my search implementation. I found many documents as guidelines for implementing that but could not end up with a working solution.
First, I have added the analyzer as follows:
PUT /products/_settings
{
    "settings": {
        "index" : {
            "analysis" : {
                "analyzer" : {
                    "synonym" : {
                        "tokenizer" : "whitespace",
                        "filter" : ["synonym"]
                    }
                },
                "filter" : {
                    "synonym" : {
                        "type" : "synonym",
                        "synonyms_path" : "analysis/synonym.txt"
                    }
                }
            }
        }
    }
}

Then I was trying to use this synonym analyzer like the following:
GET products/_search
{
    "query": {
        "multi_match": {
            "query": "television",
            "fields": ["prd_name","brand_name", "prd_sdescription"],
            "analyzer": "synonym"
        }
    }
}

I have the synonym as solr format like:
GB,gib,gigabyte,gigabytes
MB,mib,megabyte,megabytes
Television, Televisions, TV, TVs

But the search gets nothing for television while I have records for TV.
I also tried to search single field (prd_name) with synonym match, for that I need to change the but getting error when I want to change the mapping of the prd_name field.
"type": "illegal_argument_exception",
"reason": "Mapper for [prd_name] conflicts with existing mapping in other types:\n[mapper [prd_name] has different [analyzer]]"

The current mapping of prd_name is:
"prd_name": {
    "type": "text",
    "fields": {
      "keyword": {
        "type": "keyword",
        "ignore_above": 256
      }
    }
}

If someone could give me step by step solution that would be great for me.
Elasticsearch version: 6.4.1

A: Solution 1: Requires change in custom analyzer created and adding that in field name
Point 1: Add lowercase tokenizer in mapping
Whitespace tokenizer would not convert the tokens into lowercase. And in the list of synonyms, you have added 'Television' but you are querying 'television'.
Add Lowercase Token Filter in your mapping as follows and your query would give you the expected result.
Point 2: Add analyzer to the field-name
Check the prd_name as how I've created in the below mapping. Notice that I've added analyzer to it.
Mapping
PUT products
{
   "settings":{
      "index":{
         "analysis":{
            "analyzer":{
               "synonym":{
                  "tokenizer":"whitespace",
                  "filter":[
                     "synonym",
                     "lowercase"
                  ]
               }
            },
            "filter":{
               "synonym":{
                  "type":"synonym",
                  "synonyms_path":"analysis/synonym.txt"
               }
            }
         }
      }
   },
   "mappings":{
      "mydocs":{
         "properties":{
            "prd_name":{
               "type":"text",
               "analyzer":"synonym",
               "fields":{
                  "keyword":{
                     "type":"keyword",
                     "ignore_above":256
                  }
               }
            }
         }
      }
   }
}

Note that any mapping change would require you to recreate the index and ingest the documents again.
Make sure that your synonym file is available in all the nodes.
Let me know if it helps.
Solution 2: Redefine default analyzer
In case if you are not able to change the mapping of the field, what you can do is, create an analyzer with name default in the settings
Basically redefining the default analyzer with settings exactly as analyzer synonym.
That way it would be the default analyzer that'd be used instead of standard analyzer and requires no change in the mapping of field name.
Below is how the mapping would be in that case.
Mapping
PUT <your_index_name>
{
   "settings":{
      "index":{
         "analysis":{
            "analyzer":{
               "default":{
                  "tokenizer":"whitespace",
                  "filter":[
                     "synonym",
                     "lowercase"
                  ]
               }
            },
            "filter":{
               "synonym":{
                  "type":"synonym",
                  "synonyms_path":"analysis/synonym.txt"
               }
            }
         }
      }
   },
   "mappings":{
      "mydocs":{
         "properties":{
            "prd_name":{
               "type":"text",
               "fields":{
                  "keyword":{
                     "type":"keyword",
                     "ignore_above":256
                  }
               }
            }
         }
      }
   }
}

Note that I've simply renamed synonym to default in the mapping.
Important Note: Somehow you would need to reindex all the data for the changes to be in effect. In case if you do come up with having to change mapping, reindex all data, and you can do anything you'd want w.r.t field names, then I strongly suggest solution 1.
Let me know if this helps :)


There's a new type of fighter that's been quietly taking the world by storm. They're faster, stronger, healthier, and have better mental clarity—all thanks to what they put on their plate.
This new type of fighter is having much success eating vegan. They all have their strengths and reasons for choosing a plant-based lifestyle. Vegan athletes are proof that you will not be frail, weak, protein-deficient just because you decide to leave meat, dairy, and eggs out of your diet.
They put an end to the idea that being a great athlete and eating plant-based are mutually exclusive. So here is an attempt to show exactly why these fighters have so much success in their training, recovery, and performance in the ring.
Don't you feel weak? How do your muscles grow? WHERE DO YOU GET YOUR PROTEIN?!
There is an unhealthy obsession in this day and age over protein intake, or, more specifically, how to get as much protein as possible. With the huge boom in recent years in the health industry and considerable interest in high-protein diets, many people are eating as much protein as they can.
Protein supplements marketed towards athletes are sold in stores, claiming they help with muscle recovery and growth. People eat massive servings of meat thinking it will make them stronger, even with the protein supplements. There are even formulas going around saying you should eat 2 grams of protein per pound of body weight.
"Everyone is under the illusion that not only protein has to come from animals, but that they aren't getting enough of it," says Rudy Felix, a 26-year old Muay Thai fighter who has been vegan for 3-4 years.
Yes, it is true that protein is extremely important to our well-being. Protein is used to make muscles, tendons, skin, organs, enzymes, and other molecules that are important to our daily function. Without protein, we simply cannot survive. However, this concern with eating enough protein is unwarranted and unnecessary. Let's take a look at how much protein you actually need.
The Recommended Daily Allowance (RDA) for protein is 0.8 grams of protein per kilogram (or, 0.36 grams per pound) of body weight a day (g/kg/d). This means the average sedentary woman needs 45 grams of protein a day and the average sedentary man needs 55 grams a day. This is estimated to be sufficient to meet the needs of almost all healthy men and women 19 years and older (Campbell, et al., 2007).
But I do Muay Thai! Don't I need more protein than someone who doesn't exercise?
Yes… but you also need more fat and carbohydrates. Because athletes—especially Muay Thai fighters—burn so many calories during training, they need to eat more calories overall. Eating more calories automatically means proportionately consuming more protein.
Eating more protein than is necessary does not mean you will have more muscle, either. To prove this, a study was performed on "resistance-trained individuals" (think weightlifters). They fed these men and women a very high protein diet of 4.4 g/kg/d and wanted to see what the effects were when it came to muscle composition. "The current investigation found no changes in body weight, fat mass, or fat free mass in the high protein diet group" the researchers found. "The high protein group consumed an extra 145 grams of protein daily (mean intake of 307 grams per day or 4.4 g/kg/d)" (Antonio, Peacock, Ellerbroek, Fromhoff, & Silver, 2014).
Eating a high protein diet also does not seem to have positive health benefits either. It may increase the risk of osteoporosis (Sellmeyer, Stone, & Sebastian, 2001) and impair kidney function (Knight, Stampfer, & Hankinson, 2003). Too much protein releases nitrogen into the blood, which places a strain on the kidneys. A study was done by Harvard University that linked high protein diets with reduced kidney function. This damage was only seen with animal protein; plant protein seemed to have no effect (Knight, Stampfer, & Hankinson, 2003).
Animal protein has also been found to increase risk of cancer. "Specifically, certain proteins present in meat, fish, and poultry, cooked at high temperatures, especially grilling and frying, have been found to produce compounds called heterocyclic amines. These substances have been linked to various cancers including those of the colon and breast.
Long-term high intake of meat, particularly red meat, is associated with significantly increased risk of colorectal cancer. The 2007 report of the World Cancer Research Fund and American Institute for Cancer Research, Food, Nutrition, and the Prevention of Cancer reported that, based on available evidence, diets high in red meat were considered probable contributors to colorectal cancer risk. In addition, high-protein diets are typically low in dietary fiber. Fiber appears to be protective against cancer. A diet rich in whole grains, fruits, and vegetables is important in decreasing cancer risk, not to mention adding more healthful sources of protein in the diet" (The Protein Myth, n.d.).
Simply put, protein is the combination of different amino acids. There are 20 total amino acids, 9 of which are called "essential amino acids" because your body cannot produce them on its own—that is one of the reasons you eat food. Amino acids are continuously put together and taken apart depending on what your body needs. When you eat, the proteins are broken down into amino acids for your body to use, whether it's to repair muscle tissue or form new cells.
Amino acids are found in ALL foods. Yup, that apple has amino acids in it. So does broccoli. However, with the exception of soy, chia seeds, and hemp seeds, a specific plant-based source will not have all 9 essential amino acids.
This means those beans you eat have a few essential amino acids, and the rice you eat with it will have the amino acids the beans does not have. As long as you eat a variety of foods, with adequate calorie intake, you will have no problem getting the different amino acids you need, and subsequently you will get enough protein!
Here is a great chart on the essential amino acids and the plant-based sources you can get them from!
But that seems like a lot of work…can't I just eat a piece of meat and get all 9 essential amino acids at once?
Yes, you can. But keep in mind that just as you can have a poor, uneducated plant-based diet (there is such a thing as a junk food vegan), you can just as easily have a poor, uneducated diet that includes meat. The typical western diet includes lots of meat (cholesterol, saturated fats) along with refined sugars and poor amounts of vitamins and fiber. We live in a world where unhealthy food is much cheaper and more widely-accessible than healthy food. Any sort of attempt to eat better will take some work! But at least with a vegan diet, you avoid the negative side effects such as kidney and bone issues, high blood pressure, and cancer.
So what happens to that extra protein you eat?
Again, from the National Research Council (US) Subcommittee from 1989: "Amino acids consumed in excess of the amounts needed for the synthesis of nitrogenous tissue constituents are not stored but are degraded; the nitrogen is excreted as urea… utilized directly as sources of energy or are converted to carbohydrate or fat." Yup, that extra protein can be used either as energy… or stored as fat!
What about B12? Iron? Creatine levels?
There's a saying in the vegan community: Tell someone you're going to eat McDonald's and nobody says anything, but tell someone you're going vegan and everyone suddenly turns into a nutritionist or doctor. Keep in mind that while vegans do have to make sure they get the proper vitamins and nutrients, so do people who are not on a plant-based diet!
Low levels of B12 can cause nerve damage and anemia, but a diet that includes a variety of foods should raise no concern to the levels of B12. B12 is found in spirulina and seaweed. Many foods are also fortified with B12, such as cereals, plant-based milks (soy, almond, rice, etc.), energy bars, and nutritional yeast. B12 is one of the few vitamins that are stored in substantial amounts in the liver until it is needed. "If a person stops consuming the vitamin, the body's stores of this vitamin usually take about 3 to 5 years to exhaust" (Johnson).
Iron is a part of hemoglobin, which helps to carry oxygen in the blood. "Some might expect that since the vegan diet contains a form of iron that is not that well absorbed, vegans might be prone to developing iron deficiency anemia. However, surveys of vegans have found that iron deficiency anemia is no more common among vegetarians than among the general population although vegans tend to have lower iron stores" (Mangels, n.d.). Also, the amount of iron found per 100 calorie serving of food is much higher in plant-based sources! Generally, dark leafy greens are excellent sources of iron and consuming foods high in vitamin C (such as fruit) helps to increase iron absorption in the body (Hallberg, 1981).
Many people, especially weightlifters, supplement their training with creatine because it supposedly increases power output. Creatine can be made by the body, and it can also obtained by eating meat and fish.
People on vegetarian and vegan diets do have lower levels of creatine in their bodies but that does not mean they are weaker! Some studies done show that creatine supplementation has no effect on power output (Clarys, Zinzen, Hebbelinck, & Verlinden, 1997), while one study showed that creatine supplementation did increase power output, but guess which group had the highest increase in power? Yup, those on a plant-based diet who supplemented with the same amount of creatine as meat eaters (who get additional creatine through their diet) increased their muscle mass and power output way more (Burke, et al., 2003).
Also, keep in mind that having a high power output on paper (like being able to deadlift 1,000 pounds) does not mean it will transfer over into functional power when it comes to Muay Thai. There are plenty of meatheads at a regular gym who can't throw a punch nearly as hard as someone who can lift half as much.
That being said, let's take a look at some vegan athletes (including fighters) that trump their meat-eater counterparts.
Carl Lewis won 10 olympic medals and 10 World Championship medals in his career running track. He said his best year was his first year eating vegan.
David Carter is a 28-year old NFL defense lineman and calls himself the 300-pound vegan. He advocates his lifestyle through social media and says you don't have to take a life to gain muscle.
Venus and Serena Williams, sisters and stars in the tennis world, announced they were going fully vegan in 2011.
Cam Awesome is a decorated boxer and is currently representing the U.S. in boxing at the Rio Olympics. He is ranked #4 in the world.
Okay…so it is possible (and very easy) to get enough protein, vitamins, and minerals through a vegan diet. What other benefits are there to eating vegan?
Before going out to eat, look on the website for items that can be easily be made vegan (eg, telling them to leave out the cream sauce) or even items that are already vegan! You can also call the restaurant ahead of time and let them know you are vegan – many times, they will be happy to accommodate and make something for you off-menu.
Keep in mind that when you do go vegan, not everyone will understand it, and some people will try to dissuade you from doing so. The vegan jokes will not stop, so don't get angry and pick your battles wisely. Use it as an opportunity to prove people wrong and show that you can thrive without meat, eggs, and dairy. Lead by example.
Special thank you to everyone who took time to answer my questions, even the ones who are not featured in this article.
Antonio, J., Peacock, C. A., Ellerbroek, A., Fromhoff, B., & Silver, T. (2014). The effects of consuming a high protein diet (4.4 g/kg/d) on body composition in resistance-trained individuals. Journal of the International Society of Sports Nutrition.
Burke, D., Chilibeck, P., Parise, G., Candow, D., Mahoney, D., & Tarnopolsky, M. (2003). Effect of creatine and weight training on muscle creatine and performance in vegetarians. Med Sci Sports Exerc., 1946-1955.
Campbell, B., Krieder, R. B., Ziegenfuss, T., La Bounty, P., Roberts, M., Burke, D., . . . Antonio, J. (2007). International Society of Sports Nutrition position stand: protein and exercise. Journal of the International Society of Sports Nutrition.
Clarys, P., Zinzen, E., Hebbelinck, M., & Verlinden, M. (1997). Influence of oral creatine supplementation on torque production in a vegetarian and non-vegetarian population. Vegetarian Nutrition, 100-105.
Hallberg, L. ( 1981). Bioavailability of dietary iron in man. Ann Rev Nutr, 123-147.
Johnson, L. E. (n.d.). Vitamin B12 (Cobalamins). Merck Manual.
Knight, E., Stampfer, M., & Hankinson, S. (2003). The impact of protein intake on renal function decline in women with normal renal function or mild insufficiency. Ann Intern Med, 460-467.
National Research Council (US) Subcommittee. (1989). Recommended Dietary Allowances: 10th Edition. Washington (DC): National Academies Press (US).
Sellmeyer, D., Stone, K., & Sebastian, A. (2001). A high ratio of dietary animal to vegetable protein increases the rate of bone loss and the risk of fracture in postmenopausal women. Am J Clin Nutr 2001, 118-122.


text:
ME3 may refer to:

 ME3 (gene)
 Maine's 3rd congressional district
 Maine State Route 3
 Mass Effect 3
 ME3 carriers


text:
CAF Paralympics poll
A survey of the public on behalf of the Charities Aid Foundation.
Health Media Public and communities Social UK
Further Description
Immediate "Paralympic effect" has made people more positive about disability
The London 2012 Paralympics has led to a significant increase in people feeling positive about the role of disabled people, according to polls tracking how perceptions have changed during the Paralympic Games.
Surveys by ComRes carried out immediately before the Paralympics and over the last weekend of the Games, show that three quarters of people (76%) say they feel positive about the role of disabled people in UK society, up from 68% a fortnight ago.
The research, commissioned by the Charities Aid Foundation (CAF), which promotes charitable giving and provides financial services and social finance to not-for-profit organisations, found 81% of the public agree that disabled people often experience prejudice and discrimination, up from 74% a fortnight ago.
ComRes surveyed people between 24-25 August before the Games opened, and again between 7-9 September over the last weekend of the Games.
The survey found strong support for charities working with disabled people. Nearly three quarters of people (73%) believe it is important to donate to charities working to support disabled people in the UK, consistent with opinion before the Games.
The research also showed that people see disabled people as role models for society. Nearly two out of three people (79%) say that the media should do more to promote disabled people as role models in society.
The survey found:
• 76% of people agree that the Paralympic Games are making them feel more positive about the role of people with disabilities in UK society, up from 68% before the Paralympics
• 73% of people believe it is important to donate to charities that work to support disabled people in the UK, compared with 72% before the Paralympics
• 45% of people agree that the Paralympic Games will make them more likely to give to charities that help disabled people, up from 44% before the Paralympics
• 76% of people agree that disabled people often experience prejudice or discrimination in UK society, up from 68% before the Paralympics
• 79% of people agree that the UK media should do more to promote people with disabilities as role models in society
up from 78% before the Paralympics
• 78% of people agree that, "with the exception of the Paralympic Games, disabled people are not generally visible in UK media" compared with 72% before the Paralympics
• 37% of people agree that the British Government does enough to support disabled people in the UK, down from 39% before the Paralympics
Richard Harrison, Director of Research at the Charities Aid Foundation, said: "The Games has been an incredible, life-affirming celebration of sport and humanity. The Paralympic Games have already started to change attitudes to disabled people.
"It is great to see such strong support for charities which work with disabled people. This summer of sporting excellence has shown what can be achieved when both athletes and the volunteers helping to deliver the Games, give their time and commitment.
"The feeling of the nation rallying round a great sporting cause has been fantastic. One fantastic legacy of the Games would be for people to think of new ways to support the causes they really care about."
ComRes interviewed 2102 British adults online between 7th and 9th September 2012. ComRes also interviewed 2045 British adults online between 24th and 27th August 2012 – the weekend before the start of the Paralympic Games. Both sets of data were weighted to be demographically representative of all GB adults. ComRes is a member of the British Polling Council and abides by its rules.
Download CAF_Paralympics poll (0MB)


A collection of essays written by William Blum, some of which were published over the past decade in various magazines and anthologies, some appeared in his regular internet newsletter: The Anti-Empire Report, some which appeared only on his website, and some written explicitly for this book.
Myth and Denial in the War on terrorism: Just why do terrorists terrorize?
Hiroshima: Last military act of World War II or first act of the Cold War?
To purchase Freeing the World to Death by credit card, take note of the price and use the PayPal button below.
Or purchase it online elsewhere: Amazon; Common Courage Press.
This book is also available in Italian and Finnish. Contact the author at for further information.