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, né le  à Yokohama et décédé à l'âge de 85 ans le  à Tokyo, est un bureaucrate et homme politique japonais des ères Taishō et Shōwa qui fut très présent dans l'administration du Mandchoukouo.

Biographie
Hoshino est né à Yokohama où son père travaille dans l'industrie textile. Sa tante paternelle fut principale du collège Tsuda, une université pour femmes réputée.

Devenu membre de la clique financière dirigeante Ni-Ki-San-Suke par l'intermédiaire de son père, Hoshino sort diplômé de droit de l'université impériale de Tokyo avant de travailler au ministère du Trésor. Il gravit les échelons dans différents secteurs allant de la régulation bancaire à la taxation et, en 1932, devient vice-ministre du développement industriel.

Après l'invasion japonaise de la Mandchourie et la création de l'État fantoche du Mandchoukouo, il mène une équipe de bureaucrates du ministère du Trésor en  pour fournir une structure financière au nouveau territoire. En 1937, il devient vice-ministre des Affaires financières du Mandchoukouo. Il dirige ainsi personnellement le bureau d'État du monopole de l'opium qui propage à grande échelle l'usage des narcotiques, d'abord en Mandchourie puis en Chine, afin d'atténuer la résistance de la population à l'occupation et à l'expansion japonaise tout en engendrant des profits colossaux. Sous son autorité, des dizaines de milliers d'hectares sont confisqués pour y planter du pavot, tandis que des dizaines de laboratoires sont construits pour transformer le goudron d'opium en morphine ou héroïne de différentes qualités. L'économie mandchoue devient ainsi inextricablement liée aux drogues dures. Ce succès administratif fait du Japon en 1935 le plus grand fabricant de narcotique du monde, produisant environ trois tonnes ou 10 % du volume total de morphine et 37 % de l'héroïne. Selon le testament du général Ryūkichi Tanaka lu devant le tribunal militaire international pour l'Extrême-Orient, durant son poste en Mandchourie, les revenus issus du trafic d'opium et autres narcotiques devinrent la première source de liquidités du gouvernement du Mandchoukouo. Une partie de ces narcotiques est exportée vers le Japon où elle est utilisée par la compagnie de tabac Mitsui pour produire des cigarettes spéciales pour le marché chinois sous la marque , très populaire en Extrême-Orient. Contenant de petites doses d'opium à leur embouchure, ces cigarettes provoqueront l'addiction de millions de personnes et contribueront au délabrement de la société chinoise tout en procurant d'importants profits à l'économie japonaise évalués à (toujours selon le testament) 300 millions de dollars d'avant-guerre chaque année.

Ayant réussi avec succès sa mission d'établir la bonne santé de l'économie japonaise en Mandchourie, Hoshino est rappelé au Japon en 1940 pour prendre la tête du « département des projets » au ministère du Trésor afin de réorganiser l'économie du Japon dirigé par l'association de soutien à l'autorité impériale dans le second gouvernement de Fumimaro Konoe. En 1941, il devient membre de la chambre des pairs et est nommé secrétaire général du Cabinet dans le gouvernement de Hideki Tōjō avec pour mission de basculer l'économie du Japon en économie de guerre sur la base d'un socialisme d'État.

Après la défaite de 1945, il est arrêté par les forces alliées et jugé au tribunal militaire international pour l'Extrême-Orient en tant que criminel de guerre de classe A sur les chefs d'accusation 1, 27, 29, 31, 32 en même temps que d'autres membres de l'ancienne administration du Mandchoukouo responsables des décisions de l'administration japonaise. Il est reconnu coupable et condamné à la prison à vie à la prison de Sugamo de Tokyo tandis que son proche allié, le général Kenji Doihara est reconnu coupable de contrebande de narcotiques dans les zones occupées et non-occupées et est condamné à mort et pendu. Selon l'acte d'accusation, en tant qu'outils des gouvernements japonais successifs ils « .. poursuivaient une politique visant à affaiblir la résistance des populations autochtones (. . .) en encourageant directement ou indirectement l'augmentation de la production et l'importation d'opium et autres narcotiques et en soutenant la vente et la consommation de diverses drogues ».

Il est libéré de prison en 1958 et devient président de plusieurs compagnies, dont la Tōkyū. Il publie ses mémoires en 1963, qui créent un peu de sensation en raison de l'admiration toujours importante pour les accomplissements japonais au Mandchoukouo, et pour son manque de respect au dirigeant Hideki Tōjō. Il meurt à Tokyo en 1978.

Bibliographie

Notes et références

Source de la traduction

Étudiant de l'université de Tokyo
Membre de la chambre des pairs du Japon
Personnalité du Mandchoukouo
Personne condamnée pour crimes de guerre commis pendant la Seconde Guerre mondiale
Trafic de stupéfiants
Naissance à Yokohama
Naissance en avril 1892
Décès à Tokyo
Décès en janvier 1978
Décès à 85 ans
Personnalité politique de l'association de soutien à l'autorité impériale


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New order indefinitely bars almost all travel from seven countries
By News Sources, September 25, 2017
The New York Times reports: President Trump on Sunday issued a new order indefinitely banning almost all travel to the United States from seven countries, including most of the nations covered by his original travel ban, citing threats to national security posed by letting their citizens into the country.
The new order is more far-reaching than the president's original travel ban, imposing permanent restrictions on travel, rather than the 90-day suspension that Mr. Trump authorized soon after taking office. But officials said his new action was the result of a deliberative, rigorous examination of security risks that was designed to avoid the chaotic rollout of his first ban. And the addition of non-Muslim countries could address the legal attacks on earlier travel restrictions as discrimination based on religion.
Starting next month, most citizens of Iran, Libya, Syria, Yemen, Somalia, Chad and North Korea will be banned from entering the United States, Mr. Trump said in a proclamation released Sunday night. Citizens of Iraq and some groups of people in Venezuela who seek to visit the United States will face restrictions or heightened scrutiny.
Mr. Trump's original travel ban caused turmoil at airports in January and set off a furious legal challenge to the president's authority. It was followed in March by a revised ban, which expired on Sunday even as the Supreme Court is set to hear arguments about its constitutionality on Oct. 10. The new order — Chad, North Korea and Venezuela are new to the list of affected countries and Sudan has been dropped — will take effect Oct. 18. [Continue reading…]
Filed Under: Donald Trump, human rights, immigration, Iran, Islamophobia, Libya, News, North Korea, refugees, Somalia, Syria, Yemen

redpajama_set_name: RedPajamaCommonCrawl


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Solintal Unveils 40-Ton Loader Bucket at Smopyc Fair
Quality and service are the two words that best define a leading company in the manufacture of buckets, tools, and all kinds of structures used in engineering projects, and in the energy, construction, and cement sectors, among others.
Revista técnica Rocas y Minerales 543
Solintal is a company based in Madrid with over 125 employees. It specialises in steel manufacturing, particularly in cutting, bending, boring, countersinking, turning, shot-blasting, and welding.
Solintal is known for its high degree of specialisation, the excellent quality of the products it makes, and unbeatable after-sales services. With facilities covering over 16,000 m2, in recent years Solintal has become known for being a modern company with a philosophy based on innovation, improving its services, and adopting a personal approach with customers.
Proof of this are the 130-plus excavator mining buckets that the company makes every year for important machinery manufacturers such as Komatsu, Liebherr, and Esco. It also makes tools for machinery weighing over 100 tons. Many of these are made from start to finish in the company's base in Madrid: dredging equipment, like the ones it makes exclusively for Esco; water tanks for off-highway and articulated mining trucks; chassis for special vehicles; tools for foundations; bulldozer blades; structures for railway vehicles; etc.
One of the most eye-catching examples was recently unveiled during Zaragoza's machinery fair. Solintal, one of the world's largest manufacturers of buckets for excavators and loaders in the mining sector, attended the 2017 Smopyc fair with a spectacular example of the quality of its manufacturing capabilities. It was a 40,000-kg bucket; specifically, a very large bucket for a Komatsu PC5500 backhoe loader with a 28 m3 capacity. This object caught people's attention more than any other at Smopyc. There was also a photo booth inside it, which was used by everyone, from the authorities who opened the fair, to children who were amazed by the size of the bucket, as well as other visitors who were simply curious.
The 40-ton bucket shown in Zaragoza, from a Komatsu PC 5500 backhoe, was just as impressive as the one shown at the 2016 fair in Bauma, which was also made by Solintal, and displayed outside the fair, mounted on a Komatsu PC 7000 backhoe loader.
Solintal is undoubtedly a leader in manufacture of loader buckets and tools for different sectors. It has reached this status thanks to the quality of the products it makes and the service it offers its clients.
Members of the Smopyc 2017 inaugural committee, with Rafael Chavarri, manager of Solintal, in the photo booth inside Solintal's bucket. From left to right: Rafael Chavarri, manager of Solintal; Vicente Guillén, Presidential Advisor of the Government of Aragón; Gustavo Alcalde, Delegate of the Government of Aragón; Manuel Teruel, president of the Zaragoza Fair; Pedro Santisteve, Mayor of Zaragoza; and Stoian Markov, President of Smopyc.
Fuente: Rocas y Minerales 543: Solintal expone un Cazo de 40 toneladas en la Feria de Smopyc
Solintal continues manufacturing and delivering buckets for the Komatsu PC5500
Solintal: fabricación a medida
Cazos y Baldes que necesita el sector minero
Solintal commissioned by Sánchez y Lago to build a 90.000-litre cistern
Mining Catalogue


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After a lifetime of research in computational linguistics, semantics, and dialogue, Manfred Pinkal is going to retire this autumn.
We will celebrate Manfred's academic life to remind him and us of the impact he has had on his research fields and on the lives of other people in style with a one-day workshop on October 1. We envision a day at which some of Manfred's closest friends and collaborators speak about Manfred the scientist, Manfred the academic politician, and especially Manfred the person. Of course, knowing Manfred, such an event would not be complete without giving the man himself the opportunity for a speech, and there will also be food and drinks.


Last weekend FOS pulled off an incredible Bar and Bat Mitzvah for two siblings that love the sea. The complex decor explored the ocean's diversity of colour and texture, taking guests on an underwater journey that began with a beach-inspired entrance, and coasted through an immersive underwater event space.
Guests began their evening in a beach-themed lobby with a tiki hut, decaled bars and a sleek black lounge space. The decor was minimalistic, and consisted of scenic backdrops and bar decals, palm trees, and surfboard seating.
After enjoying a drink with friends, guests were submerged into the main event space, which was designed to explore the ocean depths.
Every table had a starfish table number on a twine-wrapped base, with colourful table linens and matching chair covers. Half of the centerpieces consisted of painted Manzanita "corals" with hanging ornaments – fish, seahorses, octopuses, etc. – on a mossy green base with seashells. The rest of the centerpieces consisted of water and coral filled glass vases with live swimming fish, topped with an arrangement of hanging amaranthus, red coral and sword fern that looked like sea grass, with a mossy green base decorated with seashells.
Oceanic backdrops lined the room and became the canvas for our artistic team. Working in from the backdrops, we set up decaled bars and food stations, each sporting its own underwater scene.
Around the floor of the room we created three dimensional reef vignettes made of seahorses, moss, and painted manzanita trees to give the scene dimension and texture.
From the ceiling we hung a massive great white shark prop, and strung up clusters of jellyfish made from iridescent material and light fabrics that caught the air and shimmered as if floating gently by.
We completed the scene with a light white lounge area that popped against the vibrant colours of the rest of the room. The lounge featured white sofas and ottomans, Manhattan coffee tables, and square glass votives filled with blue fish tank pebbles, small shells, a bright white LED light and red manzanita branches painted to look like coral.
With such a fun, unique concept to work our team was incredibly inspired throughout the entire design process leading up to this event. Our range of artistic talent was given a chance to shine, and our clients were thrilled with the creativity and level of detail we were able to achieve for this momentous event.


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Happy New Year's Eve (and 7th day of Christmas)! By now you may have sorted through the myriad of gifts you received. Some you may care for more than others. So, what is a good Southern Belle to do with the gifts she doesn't exactly care for? I'm glad you asked, and I'm here to help.
First and foremost, regardless of how much you like a gift, it is worthy of a thank you note. Yes, I know that traditional etiquette says that if you thanked the gift giver in person, you are exempt from having to write a note. That's just not commonly practiced in the South. Here, if you receive something, you send a note UNLESS the gift itself was a thank you gift.
Secondly, you are free to re-gift, provided a few rules are followed. When you are re-gifting, you should carefully considering to whom you will give the gift. You don't want the future recipient to be put in a position of re-gifting it yet again. Try your best to make sure it will be appreciated by its future owner. If you can't think of anyone who would want/like the gift, return it if you know where it was purchased. If not, donate it to a good cause.
When re-gifting, try your absolute best to make sure the original gifter does not find out about said re-gift. It was undoubtedly hurt his or her feelings. For example, if it was given to you by your mom, do not re-gift it to your brother.
For this rule, I speak from personal experience: Do not re-gift in the same bag you received the item in unless you've double-checked for name tags that could be a dead giveaway to the item being a re-gift.
Now for an aside: My car stays a wreck. I don't know why. I feel like I continuously clean it out, but with two kids, stuff keeps getting shoved back in. I'm also in several clubs and organizations, so I have notes, minutes, etc. floating around always. This year, I gave my sister-in-law a gift I purchased for her. Read – not a re-gift. Anyhow, I'm pretty sure one of my Dial Study Club thank you notes somehow made its way into the bag, so she likely thought it was a re-gift. This is why I prefer to use wrapping paper. It's much harder for inanimate objects to work its way into that.
Ok, back to the actual story. Regarding name tags – making sure bags are clear of old name tags is a good rule of thumb, even if the actual gift is not a re-gift. I cannot bring myself to throw out perfectly good gift bags that were briefly used. I cannot tell you the last time I re-gifted anything, but I CAN tell you it's difficult when a bag says it's to both my aunt and my mom. Mommy brain.
There you have it! A few, simple re-gifting guidelines to consider when sending gifts to a new home.
Door Etiquette – Who Opens For Whom?
First, if at all possible, etiquette, particularly in the South, leans toward a man opening a door for a woman. It's not because she isn't capable. It's a sign of respect. Just like in introductions, the woman is the "more important" person, the same holds true for door opening. Likewise, a younger man should hold the door open for an older man. However, there's no sense in racing to the door to accomplish this task. If the woman gets there first, it's completely ok for her to open the door. If a group of people are exiting a "push" door, and the first person through happens to be a woman, she should hold the door for the others. A respectful man will at least offer to take over the task for her. She may freely decline, if she so chooses.
Secondly, unless there's a tornado or zombie apocalypse outside, people always exit before people enter. I don't care if it's from an elevator or a restaurant. If you are trying to enter a place, ALWAYS wait for those who are trying to immediately exit. There's practicality behind this, too, particularly in smaller space, such as an elevator. There's only so much room before it's physically impossible for one to exit due to crowdedness.
It's always kind, regardless of gender, to hold the door for the person behind you. In olden days, a man would push a door out and allow the woman through before following her out. If a man's objective is to be kind and hold the door open, he may follow that suggestion OR he may head out first, holding the door for her exit. The woman may also just walk through, holding the door open behind her for him.
Finally, please say thank you to anyone, male or female, kind enough to hold a door open for you. You're not accepting a proposal. It's just a simple, nice gesture, and the world could sure use more simple, nice gestures.
As always, thank you for reading! I'd love to hear your thoughts!
Merry Christmas!! If you are feeling behind in getting your Christmas cards out, take heart! You have until the Epiphany (Jan. 6th) to do so!
Now, for the first part of the changes that are coming!!!!
Tonight I will host the FIRST (of, hopefully, many) Facebook Live video going over introduction etiquette! Sometimes it's easier to see than read, so I hope this helps!
I want to truly make etiquette for everyone, and I know not everyone can afford to attend one of the classes or you may not be close, physically, to Sulphur Springs.


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Jason Aldean 'Excited to Move on to the Next Chapter' With 2013 Night Train Tour
Alanna Conaway
Isaac Brekken, Getty Images
Jason Aldean's new year will consist of his first-ever stadium tour. The 2013 Night Train Tour will feature a new set of opening acts scattered dates -- including Miranda Lambert, Jake Owen, Kelly Clarkson, Luke Bryan and Thomas Rhett -- and will pick up where his My Kinda Party Tour left off.
"We're actually in the process right now of designing a new set and whole new production," Aldean reveals to Taste of Country. "[We're] revamping the whole tour, so it will be a whole new look, a whole new everything, going out next year. It will be a completely different deal. Right now it's just kind of in the designing stages of the stage and the lights and video. We're kind of getting all that stuff together right now."
Perhaps Aldean will have a better grasp on planning a new trek after he bids farewell to his current monster success, the My Kinda Party Tour, which is set to wrap on Oct. 27 in Dallas, Texas. While Aldean is grateful for everything the tour and album have done for his career, he is looking forward to closing one door and opening another.
"I think that record and this tour and everything about this My Kinda Party ride has been not only a career-changing thing, but a life-changing thing for me," he explains. "It will always be a really, really special record for that reason, the tour -- everything about it -- but at the same time, I feel like it's served its purpose. It did more than I could have ever hope for it to do. I'm kind of excited to move on to the next chapter. I feel like we have a great record to come behind that with, and kind of keep the 'train' rolling."
Jason Aldean 2013 Night Train Tour Dates (So Far):
4/13 - Athens, Ga. | Sanford Stadium (Luke Bryan, Jake Owen Thomas Rhett)
7/13 - Boston, Mass. | Fenway Park (Miranda Lambert, Jake Owen, Thomas Rhett)
7/20 - Chicago, Ill. | Wrigley Field (Kelly Clarkson, Jake Owen, Thomas Rhett)
Next: Find Out What Jason Aldean's Ringtone Is
Categories: Country Music News, Exclusives


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New X-Men (2004-2008)
Follow the exploits of the next generation of X-Men as they recover from more tragedies, celebrate more triumphs and deal with more superpowered villains than any group of kids should ever have to. Packed with wall-to-wall action, pitch-perfect dialogue and dynamic art, this is the X-Men title with something for everyone!
comiXology Unlimited
New X-Men: Academy X Yearbook Special
Collected Editions12
New X-Men: Academy X - The Complete Collection
New X-Men: Childhood's End - The Complete Collection
New X-Men: The Quest For Magik - The Complete Collection
New X-Men: Academy X
Vol. 1: Choosing Sides
Vol. 2: Haunted
Vol. 3: X-Posed
New X-Men: Childhood's End
House of M: New X-Men
Mutopia X
HOUSE OF M tie-in! Special investigator of human and mutant affairs, Ismael Ortega, teams up with ordinary cop, Lucas Bishop, to make sure terrorists from the Human Resistance Movement don't kill hundreds by sabotaging a glamorous movie premiere!
New X-Men: Hellions (2005)
From the pages of New X-Men, the resident bad boys (and girls) of Xavier's get their own miniseries. The Hellions spend the summer in California, where they'll discover the dirty secrets from one of their pasts and will face a temptation that will determine whether these kids will be heroes or villains.
Excalibur (2004-2005)
Collects Excalibur (2004) #1-4. The island of Genosha was once a thriving nation of mutants, built from the ground up by Magneto, Master of Magnetism. Then, an apocalyptic attack killed every man, woman and child-reducing an entire society to rubble within hours. Now, Professor X has come to Genosha with one intention: to rebuild a nation from its ashes!
X-Men: Legacy (2008-2012)
Professor X is forced to revisit the biggest challenge and the biggest failure of his career: Logan.


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nature reviews cancer
A Nature Research Journal
Cell motility in cancer invasion and metastasis: insights from simple model organisms
Christina H. Stuelten1,
Carole A. Parent1,2 &
Denise J. Montell3
Nature Reviews Cancer volume 18, pages296–312(2018)Cite this article
Cancer models
Cell migration
The motility of both tumour and normal host cells contributes to tumour metastasis at several steps, including breaching of basement membrane, escape from the primary tumour, migration to blood and lymphatic vessels, intravasation and extravasation and movement into distant organs. The ability to migrate towards favourable environments is a fundamental and evolutionarily conserved cellular behaviour from unicellular organisms to humans.
Both normal and cancer cells migrate using diverse modes including amoeboid, mesenchymal, epithelial, collective and individual. Simple model organisms also exhibit these diverse modes of motility and offer experimental advantages such as low cost, amenability to large-scale genetic and pharmacological screening and live imaging of cells interacting within their native environments.
Studies of the social amoeba Dictyostelium discoideum have unravelled the complex signalling networks that mediate chemokine-directed cell migration, which is also observed with human immune and tumour cells.
The combination of high-resolution live imaging and genetic screening in the nematode has revealed that cells can breach a basement membrane by pushing the matrix aside and also by degrading it. This potentially offers a new mechanism to target cancer invasion therapeutically.
Cooperative, collective cell motility appears to contribute to tumour metastasis. Border cells in the Drosophila melanogaster ovary serve as a simple model that is genetically tractable and amenable to live imaging. This model has revealed that some mechanisms of cooperative, collective cell migration, such as the requirement for E-cadherin, differ from those of single-cell motility.
Direct modelling of metastasis can be carried out in both flies and fish. Work in flies has resulted in the identification and optimization of kinase inhibitors for metastatic thyroid cancer. The fish offers the lowest-cost vertebrate model for intravasation and extravasation studies and is amenable to live imaging as well as genetic and pharmacological manipulation.
Metastasis remains the greatest challenge in the clinical management of cancer. Cell motility is a fundamental and ancient cellular behaviour that contributes to metastasis and is conserved in simple organisms. In this Review, we evaluate insights relevant to human cancer that are derived from the study of cell motility in non-mammalian model organisms. Dictyostelium discoideum, Caenorhabditis elegans, Drosophila melanogaster and Danio rerio permit direct observation of cells moving in complex native environments and lend themselves to large-scale genetic and pharmacological screening. We highlight insights derived from each of these organisms, including the detailed signalling network that governs chemotaxis towards chemokines; a novel mechanism of basement membrane invasion; the positive role of E-cadherin in collective direction-sensing; the identification and optimization of kinase inhibitors for metastatic thyroid cancer on the basis of work in flies; and the value of zebrafish for live imaging, especially of vascular remodelling and interactions between tumour cells and host tissues. While the motility of tumour cells and certain host cells promotes metastatic spread, the motility of tumour-reactive T cells likely increases their antitumour effects. Therefore, it is important to elucidate the mechanisms underlying all types of cell motility, with the ultimate goal of identifying combination therapies that will increase the motility of beneficial cells and block the spread of harmful cells.
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Figure 1: Simple model organisms can be used to investigate aspects of tumour invasion and metastasis.
Figure 2: Regulation of chemoattraction in Dictyostelium discoideum.
Figure 3: Caenorhabditis elegans anchor cell invasion.
Figure 4: Border cell migration in Drosophila melanogaster.
Figure 5: Jnk pathway signalling is a key part of metastatic spread in Drosophila melanogaster.
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The authors thank their anonymous reviewers for helpful suggestions and careful reading of the manuscript. This work was funded by the Intramural Research Program, National Cancer Institute, National Institutes of Health, by internal funding from the University of Michigan to C.A.P and by NIH grants R01GM73164 and R01GM46425 to D.J.M.
Laboratory of Cellular and Molecular Biology, Center for Cancer Research, NCI, NIH, Bethesda, MD, USA
Christina H. Stuelten
& Carole A. Parent
Department of Pharmacology, Michigan Medicine, Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA
Carole A. Parent
and Developmental Biology Department, Molecular, Cellular, University of California, Santa Barbara, CA, USA
Denise J. Montell
Search for Christina H. Stuelten in:
Search for Carole A. Parent in:
Search for Denise J. Montell in:
D.J.M. wrote the sections on Caenorhabditis elegans and Drosophila melanogaster. C.A.P and C.H.S. wrote the sections on Dictyostelium discoideum and zebrafish. All authors contributed equally to writing the other parts of the article and reviewing and/or editing the manuscript before submission.
Correspondence to Carole A. Parent or Denise J. Montell.
CbioPortal
PowerPoint slide for Fig. 1
Lamellipodium
A quasi-two-dimensional structure localized at the leading edge of motile cells that contains a highly dynamic actin network.
Lamellum
A structure containing stable actin filaments and mature adhesion sites localized just behind the lamellipodium.
A thin, fibrous membrane that separates epithelium, mesothelium or endothelium from the underlying stroma.
A family of low molecular mass proteins that are secreted by various cells and regulate a variety of responses, including cell migration, morphogenesis and proliferation as well as angiogenesis by binding to G protein-coupled receptors.
(MMP). Calcium-dependent, zinc-containing endopeptidases that degrade matrix proteins.
Mesendoderm
An embryonic tissue layer that differentiates into mesoderm and endoderm.
Directional persistence
A measure commonly defined as the ratio of displacement to trajectory length.
Stuelten, C., Parent, C. & Montell, D. Cell motility in cancer invasion and metastasis: insights from simple model organisms. Nat Rev Cancer 18, 296–312 (2018) doi:10.1038/nrc.2018.15
Issue Date: May 2018
DOI: https://doi.org/10.1038/nrc.2018.15
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text:
Inform, Engage, Empower
Make the most of your time with your rheumatologist by understanding the content and flow of a typical appointment.
By Diana Price
Shannon Wylie was diagnosed with rheumatoid arthritis (RA) in 1978; she was four years old. Since the diagnosis the San Antonio, Texas, resident has used a wide range of medications and has undergone several surgeries; she had her right hip replaced when she was 12 and her left at 21; in 2006 she had to have the right hip replaced for a second time. "There has been a lot of damage done at this point," Shannon says. "I tell everyone I'm in the repair stage."
Given how many years Shannon has been living with RA, it's fair to say that she has spent her share of time in doctors' offices—and specifically in rheumatology clinics. Today she sees her rheumatologist every three months, more often if she is experiencing a significant flare. Treating the disease has been an ongoing journey, she says, as she has worked with her doctor to find effective therapies. She feels grateful that her current treatment plan—which includes weekly injections of the biologic drug Orencia® (abatacept), Azulfidine® (sulfasalazine, a sulfa drug that treats pain and swelling), and Rayos® (prednisone, a delayed-release steroid)—is working well: "The medicine I'm taking now has been preventing more damage and controlling everything."
Like many women who live with RA, Shannon depends on regular monitoring and engagement with her rheumatologist to manage the chronic condition. The relationship she has developed with her doctor and the dialogue that the two engage in when she has an appointment empower her to proactively manage the disease.
As a patient, understanding how your time and connection with your rheumatologist can best serve your needs is an important step in managing the disease.
What to Expect in Your Rheum Exam
Stacy Kennedy, MD, a rheumatologist at Rowan Diagnostic Clinic in Salisbury, North Carolina, treats patients managing RA and other autoimmune diseases. She says that when she sees an RA patient, a typical appointment will include disease assessment and disease management.
Often patients make an appointment because they are experiencing more pain than normal, Dr. Kennedy says, so assessment and management are directed at relieving that pain. "During disease assessment we are asking questions and performing a physical exam, working to determine what is causing a patient's pain or flare," she says.
Disease assessment will generally include a physical exam, during which the doctor will ask you to describe your current symptoms; listen to your heart, lungs, and bowel; take your pulse; and check for signs of inflammation (swelling, redness, heat, rashes) all over the body. He or she will also press on or squeeze all of your joints. (Shannon jokes that this is the "mini massage" portion of the exam.)
Another important aspect of a visit with your rheumatologist is a discussion of disease markers in the blood to monitor RA. Dr. Kennedy says that she looks carefully at "the complete blood count, as well as liver and kidney function and inflammatory markers." Dr. Kennedy also includes Vectra® DA, a blood test that measures 12 markers of RA disease activity in the blood, which she says "is one of the most objective measures we have in helping to see if a patient is having a flare."
Together the information you provide about your health, the physical exam, and the blood test results provide your rheumatologist with the information needed to help you plan for treatment.
Efficient Planning for Effective Treatment
The discussion of how to best manage a patient's current disease state is most complete when a physician has all the most current information at the time of the visit. That means, ideally, that the doctor will be seeing the patient in person to assess physical symptoms and also to have the most recent blood test results.
Traditionally, this best-case scenario hasn't always been possible; the standard operating procedure in most rheumatology practices has been for patients to have blood drawn when they come in for their appointment with their rheumatologist. Because blood test results won't be available on that same day, the discussion with the physician will likely revolve around the previous round of tests, which could have been as long as three months earlier and therefore don't reflect the current disease state.
Recently, that model has begun to change. Crescendo Bioscience has developed a program to train staff to revise the standard workflow in rheumatology practices to ensure that lab results are part of the disease management discussion. Kari Kalgren, manager of strategic accounts at Crescendo Bioscience, says that the program, called practice integration, reverses the timing of testing and information sharing: patients are asked to come in two weeks prior to their appointment to have their blood drawn; lab results are then available to the provider at the time of the visit.
While it sounds like a simple switch, the change can mean significant benefits for patients. In the traditional workflow, patients would wait for information to come via a phone call. "We all know what it's like to call a doctor's office—it's a lot of phone tag back and forth," Kalgren says. "It's frustrating for patients and for the provider." But with the new approach, she says, patients get the information they want right away, allowing them "to be more of a voice in their own treatment plan because the doctor and patient are looking at the same, complete information and discussing it together."
Dr. Kennedy says that the opportunity to discuss a patient's condition with information gathered from both the lab results and the physical exam results in a much more productive dialogue. "With practice integration we have vital information from labs at the time of the appointment, so we can discuss the results with patients, and they have a much clearer sense of what the plan is when they leave the appointment."
As a patient, Shannon has seen the benefits of the new system, which was implemented at her rheumatologist's office, Rheumatology Associates of South Texas. "I never really understood why I had the blood testing the day of the appointment because during the appointment we would be talking about blood test results from three months earlier," she says. "Now my doctor is able to go over all of my markers with me; the treatment planning can be more accurate and need less adjustment."
Importance of an Empowered Dialogue
After years of discussing treatment with various rheumatologists, Shannon has learned the value of informed, empowered conversations with her provider. "I want a doctor who will sit there and listen to me—not just tell me what the tests show," she says. "I want someone who will go over every little detail and answer all of my questions."
Dr. Kennedy says that engaging with your rheumatologist in this way is key to effective care planning: "I recommend that patients ask for an explanation of labs: 'What labs were ordered and why, and what do they mean?' I want my patients to understand and communicate; it's their body and their health, and they need to know what's going on." When you have a clear understanding of your condition and treatment options, you can help devise a plan that best meets your needs. "I always tell patients that more important than the medications we prescribe is knowledge; the knowledge you gain about your disease state will have the greatest impact and will do the most to alter the course of your disease."
Shannon agrees: "At each stage of treatment, you need to ask, 'What is this treatment going to do for me? And what are the side effects?' You can't be afraid to talk to the doctor."


text:
EO Media Group to purchase La Grande, Baker City papers
SALEM — EO Media Group's presence in Oregon is set to get even stronger.
Pending court approval, the company will be adding two more newspapers to the fold with the expected additions of the La Grande Observer and the Baker City Herald, Heidi Wright, chief operating officer of EO Media Group, announced on Tuesday.
Newspaper purchase
EO Media Group, the owner of The Astorian, has purchased two papers in Eastern Oregon.
"We're excited to welcome the La Grande Observer and Baker City Herald into the EO Media Group family," Wright said. "Our family-held company has deep roots in Eastern Oregon since 1908."
The reported purchase price was $775,000 for the two papers. Fourth-generation EO Media Group owner Kathryn Brown, of Pendleton, said she is excited about the purchase.
"My cousins and I are committed to keeping local journalism alive in the rural communities we serve," she said. "We look forward to providing credible and relevant news to Union and Baker counties for many years to come."
Wright said that if all goes well, the sale will be completed July 1.
Western Communications Inc. owns the two Eastern Oregon newspapers, along with the Bend Bulletin and a few other publications in Oregon and California. The corporation filed for Chapter 11 bankruptcy protection in January. Lawyers for Western Communications told the bankruptcy court the plan was to sell property and buildings, according to court records, and in a hearing last week said all the newspapers had offers.
"A few weeks ago, the (EOMG) put in a bid to take over ownership of the papers in La Grande and Baker City," Wright said. "These towns are in close proximity to the company's other publications on the east side of Oregon, which makes this a great opportunity to strengthen news coverage for all of Eastern Oregon."
The bankruptcy court has the final say in accepting EOMG's offer. Wright said the expectation is the court is going to give the approval.
Western Communications previously filed for Chapter 11 protection in August 2011, following a three-year dispute with the Bank of America, the company's largest creditor at the time. The company emerged from Chapter 11 protection in April 2012.
Earlier this year, the motor failed on the 53-year-old press that had long printed the La Grande Observer and the Baker City Herald. Since then, the two newspapers have been printed on the East Oregonian's press in Pendleton.


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(07-16-2018, 03:49 PM)UniqueStranger Wrote: Raw veggies with homemade dip, cold chicken, and I am on the hunt for a good tuna and macaroni salad recipe. So I looked over a few recipes and decided to make it with tuna, macaroni, diced pickle and a little pickle juice, half a yellow onion lightly caramalized, asiago cheese, peas, salt & peppa, and a mix of sour cream and mayonnaise. It's quite tasty.
^ cold tuna macaroni salad on a hot summer day is a great idea..
I'll try the sliced tomato with thyme today (I have fresh thyme growing outside) with the leftovers - thanks a heap NIGHTMARE. And my nephew is a nuclear engineer and I've researched the radioactivity within the oceans, and I have to go with what the expert studies show, which is that the radiation levels are low to nil. So canned or fresh tuna is not an issue.
We are not talking about canned tuna here.
That looks mouthwatering. 86 on my back porch in the shade.
Mmm, smoked and boneless. What are herrings like to eat with the bones?
That's not necessarily so, TU, because with sardine bones they just dissintegrate and are not crunchy. Annoying posters...geeze.
I wasn't specific enough I guess, that is no reason for you to insult and bash. I explained it further later for clarity. Anyway, to explain further so you fully understand. Sardine bones are cooked in a way that they disintegrate, as I have never eaten canned/cooked herring, I am now asking if the herring bones are cooked in the same. There, fixed that for you.
I think the problem is not with my English articulation, but rather not being specific enough and reminding you that I was not asking you that question.
The question was not directed at you to interpret. Move on.
(07-18-2018, 12:22 AM)UniqueStranger Wrote: The question was not directed at you to interpret. Move on.
Me think U inglish ok.
Y can't answer feel free questions on open board postings?
What about you Fatima. Ever eat canned herring with the bones? Crunchy or not?
She doesn't eat any kind of meat, including fish, but she does enjoy the bone.


By Keith Horan | February 16, 2017.
Donore Boxing Club in Saint Teresa's Gardens has been home to many talented fighters down the years, and the club needs to muster all that fighting spirit as they battle for inclusion in the ongoing regeneration of the area.
Big Joe Egan, who was a sparring partner of Mike Tyson's for two years, is one of the club's ex-heavyweight champions, and men like Noel Reid and Noel McEvoy became Irish junior champions while boxing at Donore. Head coach Gerry Balfe Smyth believes it is vital for the area they find a new home.
Looking the part can only come after learning the basics of boxing, and for many of the club's 45 members that began as early as eight years of age. "For the eight-year old age group, it would be just learning the basic skills in boxing, how to throw a correct left jab, how to correctly throw a straight punch, repetitively getting them to do the same thing every night until they get those basics down because they are the most important parts of boxing," explained Gerry.
As they get older the club members move on to learn more advanced skills, but the coaching staff at Donore are keen to ensure all the training is carried out in an enjoyable, jovial atmosphere, befitting of The Liberties. "There's a really good community in Saint Theresa's Gardens, there always has been, and we keep that going with the kids in the area by keeping the club open for them", said Gerry, who knows how much of a positive influence boxing can have on children from disadvantaged areas.
With training on Mondays, Wednesdays and Fridays, along with visits to other clubs for sparring sessions on Thursdays and Sundays, it's also a great way to keep the kids active and healthy, especially when they grow to really enjoy the training sessions.
The club is currently hard in training for the County Dublin Boxing Championships, which take place at the end of March. Six Donore boxers will compete at the championships. Gerry also noted that the club currently have two really bright prospects in girls boxing, Brooke Roche and Charlie McEvoy, coming through the system, alongside all the talent competing at events and in the gym.
The coaches at Donore will be keen to ensure that the successful era enjoyed under Robert's presidency will be continued into the future. And hopeful that new facilities can be obtained, to keep the production line of champion boxers from the Liberties rolling.
Ireland qualifies for the Euros: What happens next?


text:
'The Game' boys
Offense, defense, Balestracci go ballistic to chill out Yale, 37-19
By Andrew Brooks Harvard News Office
Harvard running back Clifton Dawson '07 pushes aside a Bulldog for a long gain in New Haven. Earlier this year, Dawson became the first freshman in Ivy League history to rush more than 1,000 yards in a season. (Staff photos Jon Chase/Harvard News Office)
Featuring two of Division I-AA's most prolific teams, the 120th playing of "The Game" was billed as a battle of offensive might. And even though Harvard and Yale combined for nearly 1,000 total yards and 48 first downs (not to mention Yale quarterback Alvin Cowan's record-setting day of 438 yards), that tagline proved less than comprehensive at the end of the day.
To be sure, it was "The Game's" under card – the enduring, and at times, flat-out sensational Harvard defense – that served to soften the Bulldog bite, as Harvard went on to capture the Nov. 22 contest, 37-19, in front of 53,136 sun-drenched fans at the Yale Bowl.
Playing very much like it was his final game in a Harvard uniform, senior linebacker Dante Balestracci paced the Crimson defense with eight tackles, a sack and a half, and a blocked extra-point attempt. He also took the snap on a fake punt in the second quarter for an eight-yard gain. It was a gamble that set up the Crimson's next scoring drive – and its go-ahead touchdown – as Harvard took a 10-3 lead.
Freshly dubbed MVP by his teammates, Balestracci, who recently became the first player in Ivy League history to earn All-Ivy first-team honors for four consecutive seasons, topped off "The Game" (arguably one of the best of his career) with a recovered onsides kick with 1:45 left on the clock.
As a team, the Crimson denied the high-octane Yale offense when it mattered most, thrice stumping the Bulldogs in the red zone. A further testament to the clutch Harvard defense: Yale had possession of the ball nearly five and a half minutes longer than the Crimson. What's more, the Bulldogs' astounding 14 (of 22) third-down conversions proved all for naught.
Handsome Dan XVI, the Yale mascot, looks a bit dour during the fourth quarter as Harvard pulls ahead.
Harvard never trailed in the game, converting a 3-3 tie at the end of the opening quarter into a 17-6 advantage at the half. Favoring a sprained ankle and torn cartilage in his knee, quarterback Ryan Fitzpatrick '05 still managed to effectively orchestrate the Crimson all afternoon, completing 13 of 22 passes for 230 yards and four touchdowns. Rushing, Clifton Dawson '07 slogged it out on 32 carries for 174 yards – more than enough for his sixth straight 100-yard performance.
The victory secured a four-way tie for the Crimson for second place alongside Brown, Dartmouth, and Yale, who all finished with a 4-3 mark in the Ancient Eight. In the bragging-rights department, the win also established Harvard as the Big Three title-holder, having edged Princeton, 43-40, in overtime back in October. The win marks Harvard's third straight in the storied series against Yale.
Four other Crimson players joined Balestracci as first-team All-Ivy selections this season. They include Dawson, cornerback Benny Butler '04, who had a league-high five interceptions, safety Chris Raftery '04, who broke up nine passes to pace the Crimson, and offensive guard Joe Traverso '04. With seven touchdown receptions, wide receiver Brian Edwards '05 made all-league second team, along with defensive tackle Jon Berrier '04, who recorded 29 tackles. Garnering honorable mentions were Fitzpatrick, offensive tackle Joe Mujalli '04, and defensive end Brad Payne '04.
Celia Maccoby '07 gets a celebratory ride on the shoulders of Chrix Finne '07 following Harvard's victory over Yale.


I met up with local photographer Rebecca Caudell on the final day of her exhibition 'I see' in which she exhibited a number of photos taken during her time travelling around Australia, Indonesia and Thailand.
With only a fairly modest compact camera, a Nikon J4, and no accessories such as a tripod due to the limitations of space in her trusty backpack she clearly demonstrates that you do not need expensive equipment to take great photos.
Rebecca didn't even embark on her travels with the intention of taking great photos, she said "I went travelling to explore, to open my eyes, to step away from 'Life' and find out what it means to 'Live'.
"I travelled so I could sleep under stars, wake up to the sound of crashing waves and run in sand with my bare feet, sunshine kissing my skin and the warm breeze blowing in my hair. I wanted to feel free, to wake up not knowing what the day will bring.
If you missed the exhibition you can catch up with Rebecca at RAW and exhibition at the Pie Factory in Margate from 2nd to 7th September, where she will be joining other local artists including Dean Tweedy and Russell Wood.


text:
package ro.isdc.wro.maven.plugin;

import static org.junit.Assert.fail;

import java.io.File;
import java.io.FileInputStream;

import org.apache.commons.io.FileUtils;
import org.apache.maven.plugin.MojoExecutionException;
import org.junit.Test;

import ro.isdc.wro.extensions.support.lint.ReportXmlFormatter.FormatterType;
import ro.isdc.wro.util.WroTestUtils;
import ro.isdc.wro.util.WroUtil;

/**
 * Test the {@link JsLintMojo} class.
 *
 * @author Alex Objelean
 */
public class TestJsLintMojo
    extends AbstractTestLinterMojo {
  @Override
  protected AbstractLinterMojo newLinterMojo() {
    return new JsLintMojo() {
      @Override
      void onException(final Exception e) {
        fail("Shouldn't fail. Exception message: " + e.getMessage());
      }
    };
  }

  @Test
  public void usePredefOptions()
      throws Exception {
    getMojo().setOptions("predef=['YUI','window','document','OnlineOpinion','xui']");
    // ignore found linter errors
    getMojo().setFailNever(true);
    getMojo().setTargetGroups("undef");
    getMojo().execute();
  }

  @Test(expected = MojoExecutionException.class)
  public void testMojoWithPropertiesSet()
      throws Exception {
    getMojo().setIgnoreMissingResources(true);
    getMojo().execute();
  }

  @Test(expected = MojoExecutionException.class)
  public void testWroXmlWithInvalidResourcesAndIgnoreMissingResourcesTrue()
      throws Exception {
    setWroWithInvalidResources();
    getMojo().setIgnoreMissingResources(true);
    getMojo().execute();
  }

  @Test(expected = MojoExecutionException.class)
  public void testResourceWithUndefVariables()
      throws Exception {
    getMojo().setTargetGroups("undef");
    getMojo().execute();
  }

  @Test(expected = MojoExecutionException.class)
  public void testEmptyOptions()
      throws Exception {
    getMojo().setOptions("");
    getMojo().setTargetGroups("undef");
    getMojo().execute();
  }

  @Test
  public void shouldGenerateReportWithDefaultFormat() throws Exception {
    generateAndCompareReportFile(null, "jslint-default.xml");
  }

  @Test
  public void shouldGenerateReportWithCheckstyleFormat()
      throws Exception {
    generateAndCompareReportFile(FormatterType.CHECKSTYLE.getFormat(), "jslint-checkstyle.xml");
  }

  @Test(expected = MojoExecutionException.class)
  public void cannotGenerateReportWithInvalidFormat()
      throws Exception {
    final File reportFile = WroUtil.createTempFile();
    final JsLintMojo mojo = (JsLintMojo) getMojo();
    try {
      mojo.setReportFile(reportFile);
      mojo.setReportFormat("INVALID");
      mojo.setOptions("undef, browser");
      mojo.setTargetGroups(null);
      mojo.setFailNever(true);
      mojo.setIgnoreMissingResources(true);
      mojo.execute();
    } finally {
      FileUtils.deleteQuietly(reportFile);
    }
  }

  public void generateAndCompareReportFile(final String reportFormat, final String expectedFileName)
      throws Exception {
    final File reportFile = WroUtil.createTempFile();
    final JsLintMojo mojo = (JsLintMojo) getMojo();
    try {
      mojo.setReportFile(reportFile);
      if (reportFormat != null) {
        mojo.setReportFormat(reportFormat);
      }
      mojo.setOptions("undef, browser");
      mojo.setTargetGroups(null);
      mojo.setFailNever(true);
      mojo.setIgnoreMissingResources(true);
      mojo.execute();
    } finally {
      // Assert that file is big enough to prove that it contains serialized errors.
      WroTestUtils.compare(getClass().getResourceAsStream("report/" + expectedFileName),
          new FileInputStream(reportFile));
      FileUtils.deleteQuietly(reportFile);
    }
  }

  @Test
  public void shouldNotFailWhenThresholdIsGreaterThanNumberOfErrors()
      throws Exception {
    getMojo().setFailNever(false);
    getMojo().setFailFast(true);
    getMojo().setFailThreshold(9);
    getMojo().execute();
  }
}

redpajama_set_name: RedPajamaGithub