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Canada's Mood & the Travels of Justin Trudeau
By Bruce Anderson & David Coletto
Days before the Trudeau government releases its first budget, our latest poll finds that support for the federal government remains strong across the country. A majority approve of the federal government's performance, the Liberals hold a 15-point lead over the Conservatives in ballot support, and a large majority of Canadians consider Mr. Trudeau's trip to Washington to have been a success.
The results, in a nutshell, reveal:
• A steady 52% approve of the federal government performance, unchanged since November. The number of people dissatisfied has risen from 19% immediately after the election to 25% in January, and 27% this month.
• A majority in every region but Alberta approve of the government's performance. In Alberta 38% approve and 48% disapprove.
• The Liberal government has made a positive impression with NDP voters, 55% of whom approve of the government's performance. Among those who voted Conservative, 17% approve and 66% disapprove.
• During the election campaign Mr. Trudeau's opponents argued that he was "not ready" for the job. We asked if after several months on the job Mr. Trudeau critics have been proven right ("that he was not ready to handle this responsibility" or if he has proven that he "is up to handling the responsibility"). By a wide margin 70% Mr. Trudeau has shown that he is up to handling the job. A majority in every region, including Alberta (53%) feel this way. Three out of four NDP voters and 35% of CPC voters say Mr. Trudeau has shown that he was ready.
• If there were an election tomorrow, the Liberal Party would win 44% of the votes, followed by the Conservative Party at 29% and the NDP 16%. These results are unchanged from our last survey and represent a gain of 4-points for the Liberals since the October election, essentially at the expense of the NDP.
• Regionally, we see gains for the Liberals in BC and in Quebec since the election. 7% of those who voted Conservative say they would vote Liberal today, while 4% of Liberal voters would go to the Liberals. 14% of those who voted NDP would shift to Liberals today, and 3% of Liberal supporters would go to the NDP.
• Mr. Trudeau's visit to Washington DC captured some attention among 78% of Canadians, including 29% who followed it pretty closely or closely. TV news program stories were an important source for Canadians, but 41% said they followed some of the coverage live. Also worth noting is that newspaper websites were almost as important as actual newspapers. Facebook posts were a source of information for 25%. Twitter reached 6% and Instagram 3%.
• 82% considered the trip a success "from the standpoint of Canada", while 18% said it was not very or not at all successful. The consensus that it was a success was broad in every region of the country, including 61% of Albertans, and 59% of those who voted Conservative in the last election.
• When asked specifically how they felt about the way Prime Minister Trudeau represented Canada in Washington, 73% said he did a good, very good or excellent job. Another 17% characterized it as "acceptable". Only 10% said he did poor, very poor, or terrible in representing the country. Only 27% of Albertans, and only 26% of Conservative voters panned the PM's efforts. A noteworthy 44% of Conservative voters and 55% of Albertans said the PM did a good job or better.
• Finally, we asked whether people felt that Mr. Trudeau's travels since he assumed office have been "mostly a waste of time and money with too much focus on selfies and celebrity style promotion" or "adding positive visibility for Canada which will turn out to be valuable for our country in many ways. By a margin of 68% to 32% most felt that the visibility was of value for the country. This includes 54% in Alberta and larger majorities everywhere else. More than one in three Conservatives (38%) see more value than waste.
According to Bruce Anderson: "As they approach a key inflection point with their first budget, the government of Justin Trudeau continues to find fairly broad support. Clearly the Liberals' agenda has drawn support away from the NDP, whose voters are quite well disposed towards Mr. Trudeau.
While Alberta was the weakest region for the Liberals, and this remains the case, it would be incorrect to assume that Alberta voters are broadly unhappy or resentful of the new government or of Mr. Trudeau. The results paint a much more nuanced picture than that.
While critics of the PM such as Preston Manning derided Mr. Trudeau's visit to the US, Canadians generally saw things quite differently. The positive reactions to the DC visit are unusually strong and broad in an era where cynicism about politics can seem impossible to overcome.
So far anyway, Mr. Trudeau's trips, selfies and all, are far from a source of dismay for most people: instead they seem to sense value in Canada's profile being raised in a positive way."
Our survey was conducted online with 1,500 Canadians aged 18 and over from March 16 to 18, 2016. A random sample of panelists was invited to complete the survey from a large representative panel of over 500,000 Canadians.
The Marketing Research and Intelligence Association policy limits statements about margins of sampling error for most online surveys. The margin of error for a comparable probability-based random sample of the same size is +/- 2.6%, 19 times out of 20. The data were weighted according to census data to ensure that the sample matched Canada's population according to age, gender, educational attainment, and region. Totals may not add up to 100 due to rounding.
ABACUS DATA INC.
We offer global research capacity with a strong focus on customer service, attention to detail and value added insight. Our team combines the experience of our Chairman Bruce Anderson, one of Canada's leading research executives for two decades, with the energy, creativity and research expertise of CEO David Coletto, PhD.
Tags: Canadian politicsJustin TrudeauState DinnerVote intention
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Conservatives lead Liberals by 4 as inflation, healthcare, and the economy in focus.
Six in ten Canadians believe an electric vehicle will ultimately cost them less than a gas car
Canadians see a Clean Energy System as More Affordable and More Secure than a Fossil Fuel Energy Sys...
Millions Following Emergencies Act Commission. Most are Concluding Ottawa Had No Better Choice


However, both are recommendations only and not binding on the signatory countries so that while some offer reciprocity, others do not.
As far as we are aware, there are no international agreements on reciprocity among any of the ITF countries.
For those countries and regions where there is reciprocity in full or part, we have provided a notice for you to print-out explaining it to local police and parking officials.
This may all seem complicated, but we hope that the individual entries in the Guide will make it clearer.
You should look at the entry in the Guide for the country or state you will be visiting, and when you arrive always ask locally if your Parking Permit will be recognised - local people, police and parking officials will want to help you so don't be afraid to ask.
Always: ask locally, park sensibly and safely, obey the rules, enjoy your visit!


text:
Hanburia parviflora är en gurkväxtart som beskrevs av J. D. Smith. Hanburia parviflora ingår i släktet Hanburia och familjen gurkväxter. Inga underarter finns listade i Catalogue of Life.

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text:
As educator fought cancer, daily Facebook updates kept 'team' informed
"I have coached thousands of kids and I have taught thousands of kids ... But fighting cancer, they were the reason I fought so hard."
As educator fought cancer, daily Facebook updates kept 'team' informed "I have coached thousands of kids and I have taught thousands of kids ... But fighting cancer, they were the reason I fought so hard." Check out this story on mansfieldnewsjournal.com: https://ohne.ws/2H1q3p5
Jake Furr, Reporter Published 10:00 p.m. ET April 15, 2018
Follett spent 120 days documenting his cancer battle for all to see and is now cancer free.
Michael Follett stands with his wife Nancy and his grandchildren (left to right) Ava Cline, 10; Mason Follett, 6; Natalie Cline, 9 and Morgan Follett, 9.(Photo: Brian J. Smith/News Journal )Buy Photo
PLYMOUTH – There are 86,400 seconds in a day.
No one knows that more than Plymouth resident Michael Follett and his wife Nancy.
If fact, Mike has spent 10,368,000 seconds as a cancer fighter. Each day, he has posted an update about his battle on Facebook.
It all started last fall, when Mike, who just accepted a teaching position at St. Edward's School in Ashland on Aug. 1, was eating lunch. As he ate, he found he couldn't keep any food down. He would swallow it and it would get stopped and come right back up a few minutes later.
"At first, I thought I was just getting old," Mike said. "That sort of thing happens when you get old."
As time went on, it got worse and worse, so he went to the doctor and at first was diagnosed as having severe acid reflux. He was sent home with some medicine, but after 14 days of the same old stuff, he realized something was wrong. He went to a specialist who performed a gastrointestinal endoscopy. After the procedure on Oct. 26, his doctor met with Mike and Nancy, threw the papers down on the desk and delivered the bad news: Mike had esophageal cancer.
"I was so goofy from being knocked out during the procedure, and just a goofy guy in general, I said, 'Well, thank you,' while Nancy and my son Jay were crying," Mike said.
It wasn't the first time the Follotts had a cancer diagnosis. Eight years ago, Nancy was diagnosed with cervical cancer. She endured brachial therapy, where she received internal radiation. She was ordered to lie on her back for 40 consecutive hours with nothing to look at but a clock, counting the seconds away. Mike could only be with his wife of 41 years for four hours during a 24-hour period during that time, so he was counting down the seconds with her.
But the entire way, Mike was there.
Now he was facing a cancer battle of his own — but it didn't start out with his dukes up, ready to rumble.
"For the first two days, I was in complete denial," Mike said. "I didn't want to deal with it and I told myself I was going to find a different way to deal with this. That third day, I told Nancy we were going to put a team together and we were going to fight this thing."
Mike's team
Mike went right to work putting together a team to help him into battle. His first order of business was hiring a nurse advocate and he found the perfect on in Sherri Schlitt. Schlitt's job was to be with Mike during his appointments, take notes, relay messages, help with small medical needs and give him a kick in the butt when he needed it.
Also on his team was Nancy, who had been through her own battle. With a full-time job, Nancy was unable to make it to every appointment, but she was still there to offer a foot when Mike needed a kick.
"You don't do this by yourself," Mike said. "You cannot beat cancer by yourself. You must have a support staff that is there and will tell you when you screw up and how you are going to do things. Thank God I have a wife who is that way and a nurse advocate who was that way. As a man, you are thinking what is a woman doing telling me how to do things."
But they told him and told him and led him in the right direction.
"Part of you feels like you owe that to him," Nancy said. "It was hard to go to all of his appointments and still try to work and that was my plan all along. We didn't know what we were getting into with all his appointments. I couldn't go to all of them and that weighed a lot on my guilt. But Sherri was there and it was a huge help."
Along with Sherri, Nancy and their kids, Jay and Katie, Mike found a bigger team: his Facebook family. Every day, Mike would log into Facebook and let his friends know what exactly was happening, what he had to look forward to and updates on what he learned during his appointments. He let everyone know when he started chemo and radiation, when his port was implanted for his feeding tube. He told them the internet said he would have a 45 percent chance of beating this after five years.
And he would share a piece of scripture that was a perfect way to sum up his daily situation. Even though he rarely asked for prayers, he received thousands of them from his Facebook family.
"My team is probably a thousand people total," Mike said. "A lot of the reason I shared was due to our faith. I watched this woman (Nancy) go through her treatment and never lost faith in God. I was in denial and God spoke to me and told me I had to put a team together, but more importantly I had to put a group of people together who would pray for me every day.
"I decided to use Facebook as my tool. I wanted to make it a positive manner; the last thing I want is for people to feel bad for me. It is my disease and I have it and I want people to understand, we need to have our esophagus checked and every woman needs to have a breast exam and a vaginal exam every year. There are just so many things that can go by."
For 120 days, Mike posted sometimes once and other times multiple times a day, letting people know exactly what was going on. After completing chemo and radiation, on the 120th day, Mike would have a surgical procedure done to make him cancer free. On Feb. 27, the toughest part of his cancer battle would begin.
Behind his team of his wife, son, brother Brad and sister-in-law Patty along with his best friend since grade school, Mike Martinelli, Mike was ready for surgery.
"If you look at the numbers online, they are never right," Mike said. "My doctor said to never look at that 45 percent success after five years. My doctor gave me a number, the survival rate of my surgery, which is one of the most radical surgeries they do at the Cleveland Clinic, 0.2 percent of all the surgeries he does, after 30 days, that's how many people do not survive them. I am not a betting man, but if you give me those kinds of odds, I am signing up."
Mike went into surgery on Feb. 27. An incision was made from just above his belly button to the bottom of his sternum to remove 20 percent of his stomach, where the cancer had spread. After 40 stitches closed him up, he was flipped to his side, where another incision was made, tracing his right shoulder blade. The surgeon reached in, separated the muscles, collapsed his lung and cut out the diseased part of his esophagus. He then attached the good part of the esophagus to the remaining part of his stomach and repositioned everything to the right side of his chest.
In all, nine people took eight hours to complete Mike's surgery. The next morning, Mike was in excruciating pain. But right there was Nancy.
"When I was lying there wishing I could get out of the hospital, all I could see was the clock," Mike said. "I was in so much pain, I didn't want to get up, so I just laid there and stared at the clock — we have that in common. She could say, 'I know how you feel,' and she really does. I could have moved, but everything hurt so bad on the inside, I didn't want to."
The next day, Mike's sister-in-law Patty came in the room, asking him if he had been up walking yet. She continued to do that every half-hour, joined by his brother Brad. Finally Nancy chimed in to get him up and walking. After a few hours, Mike was so ticked off, he made Nancy record video as he took his first post-surgery steps.
"I wanted to get it on Facebook," Mike said. "They were just nagging me so much I just said, 'Fine, I am going to walk.' I was so mad at my sister-in-law I was going to walk around that hallway and come back and sit in my bed just to keep her quiet. When I got back in my room, I crumbled and cried. In the end, I was so thankful she pushed me. She was my coach at that point in time."
Mike spent the next week in the Cleveland Clinic before finally heading home to begin the rest of his life.
"This has been a longer and rougher road than anything we have ever experienced," Nancy said. "Everyone looks at you like it is not a good outcome and everyone gives you the sympathy look. I never once asked why me? I always asked why not me? We live in an imperfect world and disease happens."
After 120 days, 10,368,000 seconds, Mike's cancer fight was over. He was officially cancer-free.
"My race is over and all that is left is healing. I am going to be right here eight years from now watching my grandkids playing," Mike said, tears streaming down his face.
"That is our goal, enjoy those grandbabies," Nancy said. "When I was going through everything, the doctors told me to stay away from kids because they are bioterrorists, but they were all I wanted to be around. I would cry when I had to leave them. No one would stop me from seeing them."
When he returned home, he came back to an unbelievable outpouring of support. The man who spent his days teaching at Plymouth Middle school from 1975-2010 received get-well cards and letters from Texas to North Carolina and all over the United States. He had 178 prayer warriors from St. Edward's School in Ashland ready to welcome him home. And he had thousands of people sending him well wishes through Facebook.
"One of my favorite quotes is, 'Don't give up, don't ever give up,' by Jim Valvano and man, what a smart man," Mike said. "He was so smart to share that with people. He was part of my inspiration to battle this and get up in front of people and say its sucks having this. It can take my physical body, but it is not going to touch my spirit and it is not going to touch my mind. I am going to fight this to the end."
"Cancer makes you bold," Nancy said. "It makes you strong in the end. It challenged me to put a bad day behind me and stand on the Bible. I was going to pray over every piece of equipment they used for me. You felt alone, but you knew you were not alone. It just made me bolder. I would ask people to put me on a prayer list. I don't know how they get through it without faith. You go through darkness."
While Follett has worn many hats in his days as a teacher, track and field coach, husband and father, there is one that stands above them all: cancer survivor.
"It is the toughest thing I have ever done and the most satisfying thing I have ever done," Mike said. "I have coached thousands of kids and I have taught thousands of kids and they all come back to say thanks for doing what I did for them. But fighting cancer, they were the reason I fought so hard.
"Being a cancer survivor, there is going to be a tattoo right on my forearm that says, "survivor," because I want people to realize I am a survivor because of what other people did, not because of what I did. I did the easy part. I just laid there. Everyone else had to worry about me and get me to appointments on time. I love all the roles I have played in my life, but God has called me to a new thing."
Nancy wasn't surprised at the outpouring of support Mike received during his battle.
"Just the little time he spent with everyone he has ever interacted with, it circles back around and if you spend that time encouraging others, they are going to come right back and encourage you and that is a big part of healing," Nancy said.
It was the Facebook family that got Mike though some of the darkest of times, along with his major support staff.
"I remember a speech by Ashland University track coach Jud Logan," Mike said. "We had some incredible athletes who were going to win national championships, but he didn't talk about them. He talked about the athletes he called Pennies. Those were the athletes who were going to go out and score one or two points and help us win. Looking back on my life, my penny people were the ones who pushed me through prayer. I couldn't have survived without Jay, Katie and my wife. They are my 10-point national champions, but if I didn't have my penny people, I wouldn't have beat this thing."
Read or Share this story: https://ohne.ws/2H1q3p5
Things to do in the Mansfield area
Entertainment: Final Friday features 3 musical acts
Entertainment: Free summer concerts scheduled
Entertainment: Final Friday Concert Series kicks off May 31

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breadcrumbs Home » Topics A–Z » Sulfasalazine
Sulfasalazine
Author: Anoma Ranaweera B.V. Sc; PhD (Clinical Biochemistry, University of Liverpool, UK), 2013.
Sulfasalazine — codes and concepts
Treatment or procedure
5-Aminosalicylic acid and sulfapyridine, TNF-inhibitor, Immunomodulator, Off-label uses of sulfasalazine in dermatology, Pemphigus vulgaris, Idiopathic urticaria, Lichen planus, Cutaneous LE, Plaque psoriasis, Atrophie blanche, Alopecia areata, Pyoderma gangrenosum, Dermatitis herpetiformis, Adverse effects of sulfasalazine
Z79.899
What is sulfasalazine?
Sulfasalazine is an anti-inflammatory medication consisting of a combination of 5-aminosalicylic acid and the sulphonamide sulfapyridine. Currently, this drug is approved by the US Food and Drug Administration (FDA) for the treatment of ulcerative colitis and rheumatoid arthritis. Sulfasalazine has also been used for some skin conditions.
Off-label indications of sulfasalazine in dermatology
Non-approved reported uses of sulfasalazine in dermatology include:
Corticosteroid-dependent chronic spontaneous urticaria
Cutaneous lupus erythematosus
Generalised morphoea
Atrophie blanche.
With the exception of psoriasis, alopecia areata and lichen planus, all off-label dermatology indications are based on isolated case reports and/or small, uncontrolled series.
Pemphigus vulgaris represents a potentially life-threatening autoimmune blistering disease.
The use of sulfasalazine and pentoxifylline as adjuvant therapy for the treatment of pemphigus vulgaris has been assessed in at least one double-blind randomised study of 64 patients with pemphigus vulgaris.
The use of pentoxifylline and sulfasalazine induced a faster and more significant decrease in serum tumour-necrosis-factor-α levels, and this decrease was associated with rapid clinical improvement at 8 weeks in 42 treated patients compared with 22 placebo recipients.
Chronic spontaneous urticaria
A retrospective medical chart review of 19 patients with antihistamine-unresponsive urticaria treated with sulfasalazine showed that 14 patients (74%) reported significant improvement, 4 patients (21%) reported minimal improvement but were not satisfied with their symptom relief, and 1 patient (5%) reported a worsening of symptoms.
Of the 13 patients who required systemic steroids to control their urticaria, all were able to reduce or discontinue steroid use during sulfasalazine therapy.
Results of a double-blind randomised prospective trial of 52 patients with idiopathic lichen planus treated with sulfasalazine for 6 weeks (max dose 2.5 g/day) showed significant improvement in the cutaneous lesions in patients treated with sulfasalazine compared with placebo (82.6% vs 9.6%). The improvement rate of pruritus was 14.3% in the placebo group and 91.3% in the sulfasalazine group.
The effectiveness of sulfasalazine for the treatment of cutaneous lupus erythematosus was discovered by chance in the early 1990's when a patient who had been using topical corticosteroids to treat her dermatosis for the past 10 years noticed an improvement in her condition when she was prescribed sulfasalazine for suspected ulcerative colitis, followed by a recurrence when treatment was withdrawn.
Since this discovery at least 2 open-label studies, one each in Turkey and in France have assessed the efficacy of sulfasalazine in cutaneous lupus.
A complete or partial response was observed in 9 of the 13 patients enrolled in the Turkish trial and in 13 of the 18 in the French trial. In the latter study sulfasalazine (2 g/d) was given to 18 patients with severe cutaneous lupus, all of whom had contraindications for or treatment failure with antimalarial drugs and thalidomide.
The French study found a clear correlation between acetylation phenotype and treatment efficacy: nine of the ten patients showing a complete response were fast acetylators, and four of the five patients failing treatment were slow acetylators.
A response was observed within 4 to 8 weeks of starting treatment, except for scalp lesions which improved at a later date (after 4 to 5 months of treatment).
Sulfasalazine may be useful as a second-line treatment for fast acetylators with severe SLE as an alternative to thalidomide.
The efficacy of sulfasalazine 3-4 g/day in plaque psoriasis has been explored in at least 2 studies from the USA.
In an 8-week double-blind trial of sulfasalazine for the treatment of moderate-to-severe psoriasis, 23 and 27 patients received the active and placebo tablets, respectively. At the end of the double-blind phase, in 17 assessable patients receiving sulfasalazine, 7 (41%) had marked improvement, 7 (41%) had moderate improvement, and 3 (18%) demonstrated minimal change.
Only 1 patient receiving placebo demonstrated moderate improvement
Sulfasalazine may be an oral treatment option for patients with psoriasis that are unsuitable for methotrexate, acitretin, or phototherapy.
Atrophie blanche
There is anecdotal evidence that sulfasalazine 1g three times daily may be effective in atrophie blanche. which can be a chronic condition for which there is no satisfactory treatment.
In two patients, leg ulcers healed within 3 months of commencing treatment with sulfasalazine 1g three times daily.
Sulfasalazine has been used to treat alopecia areata. The literature is anecdotal.
A retrospective chart review of a series of patients from the USA showed that 7 (23%) of 30 patients with alopecia areata treated with sulfasalazine for 3 months achieved cosmetically acceptable hair regrowth. Doses ranged from 1 to 4 g per day. Eleven patients discontinued medication due to side effects, mainly gastrointestinal.
In 2 open-label studies involving 64 patients with severe recalcitrant alopecia unresponsive to topical and intralesional corticosteroids, 5% minoxidil, or psoralen plus ultraviolet-A (PUVA) there was complete hair re-growth in approximately 27-30% of patients and partial hair re-growth in 30-40% of patients after sulfasalazine therapy.
In one study, 26 patients with recalcitrant or severe alopecia areata (>40% scalp hair loss) received treatment with sulfasalazine 500 mg bid for the first month, then 1 g bid for the second month, and 1.5 g bid for a further three months.
In the second study, 39 patients with persistent alopecia areata received 3 g of oral sulfasalazine for 6 months.
Sulfasalazine has been found useful in the treatment of pyoderma gangrenosum cases that have inflammatory bowel disease.
Sulfasalazine doses start from 1-4 g daily, with the maintenance dose of 0.5-1 g daily.
In dermatitis herpetiformis, sulfasalazine 1–2 g/day may provide an effective alternative to dapsone if it fails to control the disease or dapsone causes adverse events.
How does sulfasalazine work in inflammatory diseases?
The mechanism of action of sulfasalazine has not yet been fully elucidated but is believed to be multiple.
It acts both as an anti-inflammatory and an immunomodulant, inhibiting inflammatory cell chemotaxis and cytokine and antibody production.
It acts in part as a tumour necrosis factor inhibitor.
The immunomodulatory effects of sulfasalazine seem to be particularly important when used for dermatological purposes.
It is also a folate antagonist, so it is antiproliferative.
It has antimicrobial properties.
What are the drug interactions with sulfasalazine?
Concomitant intake of sulfasalazine and digoxin may reduce serum digoxin levels by 50% resulting in a lack of efficacy of digoxin.
Concomitant treatment with azathioprine may increase azathioprine toxicity.
Rarely, sulfasalazine increases the effect of oral diabetic treatments and of warfarin.
What are the adverse effects of sulfasalazine?
Side effects are more likely in slow acetylators, who have higher plasma concentrations of sulfapyridine.
Common but harmless and transient adverse effects include:
Nausea, vomiting and diarrhoea
Dizziness.
Other rare but potentially serious adverse effects include:
Neutropenia (reduced neutrophil white cells)
A moderate increase in liver transaminases (abnormal liver function tests)
Rare pulmonary toxicity, most often eosinophilic pneumonia
Potentially fatal mucocutaneous reactions.
Potential cutaneous adverse events due to sulfasalazine include:
Lichenoid drug eruption
Drug-induced lupus erythematosus
Drug-induced photosensitivity
Drug-induced hyperpigmentation
Drug-induced alopecia
Raynaud phenomenon
Stevens-Johnson syndrome / toxic epidermal necrolysis.
Practical tips for using sulfasalazine in dermatology
As the dermatological indications are all off-label, treatment should only be started after receiving patient consent.
Contraindications to its use are:
Hypersensitivity to a sulfonamide or salicylate
Glucose-6-phosphate-dehydrogenase (G6PD) deficiency
Severe liver or kidney disease
Acute intermittent porphyria and variegate porphyria.
A pretreatment workup should include:
Complete blood and platelet count
Screening for G6PD deficiency
Liver and renal function tests with urinary protein measurement
Antinuclear and anti-DNA antibody tests if necessary
N-acetyltransferase (NAT2) genotyping if necessary.
The starting dose is 500 mg/day.
The dose is titrated up to a maximum of 3000 mg/day in divided doses.
Additional folic acid supplementation is advised.
The dose should be reduced in patients with renal disease.
The US FDA has classified sulfasalazine as Category B.
The Australian TGA has classified sulfasalazine as Category A. Category A medicines have been taken by a large number of pregnant women and women of childbearing age, without any proven increase in the frequency of malformations or other direct or indirect harmful effects on the fetus having been observed. However:
The effect that sulfasalazine has on an unborn child has not been studied extensively
Sulfasalazine should only be used during pregnancy if clearly needed
Folic acid is recommended during pregnancy to reduce the risk of neural tube defects in patients taking folate antagonists
Sulfapyridine does pass into breast milk and could affect a nursing infant
Male fertility may be reduced on sulfasalazine.
Treatment monitoring
Complete blood and platelet count, and renal and liver function tests should be carried out prior to treatment, every two weeks for two months and then every three months thereafter.
Pretest for G6PD deficiency.
Tests for antinuclear and native anti-DNA antibodies should be carried out at baseline and once a year, where necessary.
New Zealand approved datasheets are the official source of information for prescription medicines, including approved uses and risk information. Check the individual New Zealand datasheet on the Medsafe website.
If you are not based in New Zealand, we suggest you refer to your national drug approval agency for further information about medicines (eg, the Australian Therapeutic Goods Administration and the US Food and Drug Administration) or a national or state-approved formulary (eg, the New Zealand Formulary and New Zealand Formulary for Children and the British National Formulary and British National Formulary for Children).
Omidan M, Ayoobi A, Mapar MA et al. Efficacy of sulfasalazine in the treatment of generalized lichen planus: randomized double-blinded clinical trial on 52 patients. J Eur Acad Dermatol Venerol, 2010; 24:1051-1054.
Duparc A, Staumont-Salle D, Broly F et al. Traitement du lupus érythémateux chronique par sulfasalazine (18 cas). Presse Méd, 2006; 35: 1138-1142.
Wolf R, Matz H, O rion E et al. Miscellaneous treatments, I : Sulfasalazine and Pentoxifylline : unapproved uses, dosages, or indications. Clin Dermatol, 2002; 20:531-546.
Gupta AK, Goldfarb MT, Voorhees JJ. The use of sulfasalazine in atrophie blanche. Int J Dermatology, 1990; Nov; 29(9):663-5.
Turaj R, Azarmdokht AM. Treatment of persistent alopecia areata with sulfasalazine. International Journal of Dermatology, 2008; 47(8) : 850–852.
El-Darouti, M., Marzouk, S., Abdel Hay, R., El Tawdy, A et al. The use of sulfasalazine and pentoxifylline (low-cost antitumour necrosis factor drugs) as adjuvant therapy for the treatment of pemphigus vulgaris: a comparative study. British Journal of Dermatology, 2009; 161: 313–319.
A K Gupta, C N Ellis, M T Siegel et al. Sulfasalazine improves psoriasis. A double-blind analysis. Archives of dermatology 1990;126(4):487-93.
McGirt LY, Vasagar K, Gober LM et al. Successful treatment of recalcitrant chronic Idiopathic urticaria with sulfasalazine. Arch Dermatol. 2006;142(10):1337-1342.
Miranda MF. Pyoderma gangrenosum treated with sulfasalazine and dapsone. Indian J Dermatol Venereol Leprol. 2002 May-Jun; 68(3):160-1.
Gupta AK, Goldfarb MT, Voorhees JJ. The use of sulfasalazine in atrophie blanche. Int J Dermatol. 1990; 29(9):663-5.
Sabha SM, Sarka R. Sulfasalazine in dermatology: A lesser explored drug with broad therapeutic potential. Int J Womens Dermatol 2020. Journal
Sulfa drugs and the skin
Antimalarial medications in dermatology
Sulfasalazine: Consumer Medicine Information – Medsafe NZ (PDF file)
Sulfasalazine — MyMedicines New Zealand Formulary
Sulfasalazine: datasheet – Medsafe NZ (PDF file)
Sulfasalazine – MedlinePlus
Sulfasalazine – patient.info


Trivia time! What movie did this character come from? I'll give you a hint, his name is "Jack".
North American XF-108 Rapier is the plane of the week, it was a proposed fighter meant to intercept soviet threats as they approach the US. It would have a top speed of Mach 3 with a combat radius of over 1000nm! The Soviet aerial threat went away due to their use of ballistic missiles, this is a strong contributor that caused the plane to be canceled. This plane would have been a game changer, thankfully we never needed to use it or a need for it to be built but it is still a beautiful plane!
In the movie "Thor," what was the name of Thor's brother?
Keep an umbrella on hand. Not for you, but for the beautiful young lady that forgot hers.


Add me at Facebook my address is jakerpomperada@gmail.com and jakerpomperada@yahoo.com.
My email address are the following jakerpomperada@gmail.com and jakerpomperada@yahoo.com.
My mobile number here in the Philippines is 09173084360.


There is so much more to real estate than simply buying or selling a home. Having the "heart of a teacher" enables me to easily explain real estate to each client. I actively listen to each client to obtain insight, manage expectations, and proactively resolve any concerns that may arise. The goal is to go above and beyond. The focus is to serve clients throughout the entire process with warmth, integrity, and professionalism. The result is building relationships that last a lifetime.
I attended Appalachian State University in the heart of the Blue Ridge Mountains of NC, and graduated with a B.S. in Psychology and M.A. in Marriage and Family Therapy. My real estate career began in 2007. While taking a break from being an in home family therapist working with juvenile delinquents and their families, I stepped into property management. I immediately fell in love with the real estate world and have never looked back.
Having lived in 10 different counties in VA and NC, the experience has taught me the stress of relocation, and the needs that arise when moving to a new city or even across town. Building new contacts for everything from a hairstylist to a plumber starts all over. My job is to make this process as seamless as possible.
Whether buying your first home, tenth home, selling a home, or relocating, I am eager to help you every step of the way.


This is a system that works with a physical board and an app to create pixel based games. You, the builder, can create any type of game you would like and instead of learning code or advanced digital art skills, you simply build what you want with the blocks on board, they're show on the app.
Despite being a fairly simple process, this isn't really a fast process. Creators have to build every aspect of the game. Each room and character is created on the board by hand so even though using is simple, the time it takes to create is quite long. Still, the process can be rewarding! You can get a Bloxels kit for $49.95.


Being able to make a good presentation is definitely one of the most important skills that we have to possess in our life. However, in order to do that, making a good presentation that can help us deliver ideas is essential.
The challenge that I had during the preparation for Pecha Kucha was that I could not easily construct my script because I decided to find all the pictures needed before I thought about what I wanted to talk about in the presentation. After the workshop during the class I received many useful tips from my classmates and then I restarted the process and constructed my script first. Another challenge for me was that it was really hard for me to find a specific topic to talk about, because the topics I came up with were all too broad to be covered in a two minutes and thirty seconds presentation. Making the topic small and digging deeper into one specific subject is going to make a presentation more enjoyable and in-depth.
JR is one of my favorite artists because of his unique way of expression. I first knew about him by seeing him in one of the movies I watched on a flight. By posting huge portraits of human faces on different walls, or even roofs, he was able to deliver his claims implicitly that we should stand up for what we care for. The use of internet and information technology have definitely helped him share his arts with the world because internet serves as a medium where people would comment on and share different art pieces.
In order to make a good presentation, I think we should minimize the information available on the slide because we want audiences to focus on the things the speaker is talking about. If too much information is shown on the slide, audiences will tend to read what appears on the screen instead of paying enough attention, or audiences will just lose their interests. On this picture, I chose the photo which has huge eyes as the main focus, while on the top of them the word "Shocks" were typed in white in order to emphasize one of the rhetorical strategies the artist used. The best way to show audiences what kind of effects art will have is to visually show them what the art looks like in real life. This picture enables the audiences to know more about the effects of visual arts without me elaborating ineffectively about its effects.
In order to make a smooth transition from his art and the effects of using Internet, I created a connection between two transition slides by including the same art project for the second time in the second slides. That presents the abrupt transition between different topics and visually demonstrates the relationship between JR's arts and the use of Internet. From the perspective of audiences, we could better understand the influence Internet would have because the screenshot is very similar to the normal webpage we would see from day to day.
Even though the preparation for this project was really time-consuming, I'm really happy that I eventually understood the importance of being specific on one topic and overcame the fear to present in front of a crowd. If I were to do this presentation again, I would try not to use script and practice even more to be confident on the stage.


> like one precompiled for a specific architecture/bitness let me know.
> Your can view what becomes of the statistics at .
> would like to have any changes to way the plugin behaves (preferences etc).
> Hoping for your co-operation!


text:
Home › Recording
FACILITY SPOTLIGHT: DAVE DOES IMAX: TORONTO STAGE POINTS TOWARD A BIG-SCREEN TOMORROW
It would not be completely off base to imagine a team of sled dogs trekking across Dome Audio Video & Effects. The two-story facility sprawls over 50,000
By Dan Daley
It would not be completely off base to imagine a team of sled dogs trekking across Dome Audio Video & Effects. The two-story facility sprawls over 50,000 square feet of downtown Toronto and is home to more than 100 employees-mixers, audio and video engineers, digital editors, managers and account executives-creating something of a city-within-a-city. But it wasn't always this way.
Jeff Smith opened the original one-room music studio in 1972 as Jeff Smith Interchange. The facility grew as Canada's musical star rose, hosting artists such as Rush and Alannah Myles and music-heavy productions like SCTV. Then, just as the country's music fortunes retreated in the 1980s, Hollywood and Madison Avenue came knocking, seeking a haven from rising domestic production and post-production costs. The facility, meanwhile, had been bought by LaBatt's (yes, the beer brewer) and renamed Sounds Interchange. It grew to five studios doing primarily music recording and mixing, but by the late 1980s had crept into advertising, broadcast and film post-production.
LaBatt's was then purchased by Belgian beer-maker Interbrew, and Canada's legal restrictions on foreign ownership of domestic media industries kicked in, forcing the new owner to divest its interests in broadcasting. (Labatt's owned a controlling interest in regional television, as well as a stake in the Toronto Blue Jays major-league baseball franchise and their Skydome home.) The accompanying broadcast and post facilities had been renamed yet again as Dome Productions, and Interbrew spun off its entertainment properties, creating a consortium known as NetStar.
Dubbed DAVE under its present ownership, the facility is a beehive of post work, most of it coming from the U.S. and abroad thanks largely to what's been euphemistically referred to as a "very favorable exchange rate." (That rate, along with certain tax incentives, has prompted an angry response from production companies and unions in the U.S. that are seeking federal legislation to implement an import tax, among other options.) Consequently, DAVE has been pulling in foreign film, video and editorial work by the truckload in the last several years including feature films and movies-of-the-week for clients such as Showtime, HBO, Sony and Paramount, and a growing number of productions slated for DVD and other new media. And as many as 10% of all of the films done at DAVE are for the large-screen format IMAX. (It's no coincidence that the company that originated the format is also based in Toronto. The IMAX Corporation now has about 350 screens worldwide and expects to add another 100 by the end of the year.)
THEATRE ONEDAVE has 16 audio studios-eight of varying size, including a dedicated Foley studio, and another eight digital audio editing suites outfitted with Pro Tools, DAWN and ScreenSound workstations. Recording is either to DA-88, Sony 3348 digital or Studer A827 analog multitrack decks. But the crown jewel is Theatre One, one of a handful of large-format/multiformat sound-to-picture mixing studios in the world and the only one of its type in Canada. The huge room seats 60 on racked stadium-style seats in the rear. In front is a large, curved producer's desk and a 48-rail, 56-frame Studer D950S digital console.
The 17×24-foot screen can be formatted for standard aspect ratios, as well as the approximately 1.5:1 IMAX dimensions. Theatre One was designed by Claude Fortier, who also designed the specified IMAX audio monitoring system, known as SOTA. The SOTA speakers are a low-efficiency/high-dispersion system, with a single point source radiating out at 160degrees from four corners and the screen. It requires significant amplification-about 15,000 watts total-to fill the room. The room is also THX-certified, and its THX monitor specification utilizes 10 speakers arrayed in an LCRS front and rear surround configuration, with a top-screen and Voice of God speaker as well.
At DAVE, the IMAX playback system uses an Oxmoor EQ system, which can superimpose up to eight frequency response curves on the otherwise flat monitor chain, creating a full 20 to 20k Hz spectrum. "That's something you don't get in THX, which has a specific EQ curve designed for cinematic use," explains James Porteous, veteran of the facility's many incarnations and now supervisor of its extensive audio operations. "It's not really designed to mix music in, which the SOTA setup, which can actually run 20 to 20 flat, is. If you're mixing music for DVD, for instance, you'd want a flat frequency response monitoring environment in 5.1, which this gives you." As a result, Theatre One is a truly multipurpose room, usable for 5.1 music mixing and music video work, as well as film sound.
In addition to standard projection systems, Theatre One has a DLP projector, a system developed by Texas Instruments that uses as many as a million mirrors to focus light from a halogen bulb through dichromatic filters that refocus through a single aperture so that there is no RGB convergence.
Theatre One's centerpiece is the Studer D950S console, which, at ten layers deep, has a theoretical capacity of 560 inputs, though it is capable of 480 at the moment.
Porteous does not see that as overkill. "IMAX films average 300 to 350 sound sources," he says. "The one we did for Sony-Across the Sea of Time-has 450 individual sound sources. And even standard film is using more and more sound in the surround format. So it's really not that huge a number of inputs. The main reason we went with the Studer, though, was that it was highly and quickly configurable. It takes us two hours to configure the SSL 4000 we use in the other surround mixing studio. The 950 takes two minutes. And everybody loves the way it sounds, which doesn't hurt."
The 950's large input capacity is also useful for the 3-D sound that some IMAX films are using, in conjunction with 3-D picture projection that uses a pair of the DLP projectors. (The audience wears special IR binaural headsets equipped with electronic viewing filters.)
As complex as its operations are, the business philosophy of DAVE is simple enough: "In the past, the way post worked outside of Hollywood is what I call 'shoot and run,'" says Porteous. "What we're doing here is creating an environment that says 'shoot and stay.'"
DAVE exists in an increasingly rarefied stratum: the ultra-high-end facility that handles a wide range of audio and video chores, from Foley to ADR to digital editing to scoring to large-format mixing and layback. While such facilities must be able to connect their clients to any point on the globe-DAVE has operated ISDN lines routinely for years and is on the verge of implementing T3 lines-they also must interface with the numerous project studios that now handle more and more of the day-to-day work in audio. "We have Pro Tools, DA-88 and other formats for that," Porteous says. "But we're also getting formats like RADAR in here. It really is a balancing act. And it's tricky. But there's a real thrill to it, too. It's like steering a supertanker."
Dan Daley
JBL Stage 2 Architectural Series, Stage XD Series Loudspeakers Launch
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KV2 ESM312 Stage Monitor Launched
U2/Led Zep Monitor Engineer Dave Skaff Passes at 63
Cover Story: The Creative Genius Of Dave Stewart
Dave Way and Bob Clearmountain Talk A Bad Think's X
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Calendar Pocket Las Ventas 2019.
The perfect souvenir for all users who want to take a special memory of Spain very functional. Delivered in a transparent plastic sleeve.
Measures: 6 x 14 cm closed.
6 x 81 cm open.
Las Ventas Bullring was built in 1929 on the land called Las Ventas del Espíritu Santo, to which it owes its name. It is the largest bullring in Spain, with a total area of 45,800 square meters and capacity for 23,797 people. Its ring, with a diameter of 60 meters is also one of the largest in the world, after the bullring in Ronda. Las Ventas is the third Bullring with more capacity in the world after the Monumental of Mexico and the Bullring in Valencia (Venezuela), and is considered by professionals, amateurs and critics as the most important in the world.
Las Ventas Bullring, also known as The Chair of the Winds, is located in one of the windiest terrains of the city of Madrid, right in the neighborhood of La Guindalera, in the central district of Salamanca.
Calendar Pocket Las Ventas 2019 has a rating of 10 out of 10 based on 1 customer reviews.


What do you want in a tactical shoe test and review? Hard use? Lots of miles wearing a backpack? Rugged terrain? Exotic locations? Well check those boxes. I previously reviewed the Lalo Tactical Shadow Amphibian Boots and walked away more than a little impressed. Having worn them through various environments across three time zones in the USA I thought that was a pretty thorough test. Given my plans for two weeks exploring the Middle East I figured it would be an even better test. I just didn't want to wear boots.
Literally the day before I flew out of the country the Lalo BUD/S Zodiac Recon AT shoes showed up. You never know what to expect with new shoes and I was headed to a distant land. So, I packed my Salomons as backups and hopped a plane to Tel Aviv. Before I'd get home I'd hike the ancient terrain of Petra, wander the Greek and Roman roads of Jarash, Jordan, walk the Via Dolarosa in Jerusalem, hit Masada at full tilt, pound the pavement of Tel Aviv and more.
Zero Miles. They look good new.
Opening the box, "Weird" was my first thought after taking one of the Zodiac Recon AT's out of the box. Weirdly light weight, made from a material that seemed closer to a stiff paper than the usual padded shoe stuff. But they fit nicely and based on my experience with the Lalo Shadow Amphibian Boots I was optimistic.
No time to break them in, I simply put them on and ran 30 yards in front of my house. That felt good, which means little at the moment. Lalo designed the Lalo BUD/S Zodiac Recon AT like their boots with a curved sole "promoting forefoot strike and forward momentum." Marketing jargon aside, it feels like my stride is spring loaded. The spring is compressed upon impact with the ground and then released as I move forward. I don't particularly like running, so this is pretty cool to me.
It's zero dark thirty the next morning when I leave for the airport. First flight down and a four hour layover is in progress. Shoes are fine and feet happy wandering around Boston's international hub. The next flight is 14 hours. Nothing to report, but the test would start as jet lag tried to slow me down.
Tel Aviv is a busy urban center with an ancient port, Jaffa. It's supposed to be the port where Jonah skipped town before being tossed overboard to the whale. Walking through the old town and modern city sidewalks I was pretty happy to have missed those old days. My feet were feeling great. The Lalo BUD/S Zodiac Recon AT shoes aren't squishy, they are firm but absorb my weight plus another 26 pounds from the backpack I'm wearing everywhere. I have no idea how many miles I logged around the Tel Aviv, but I was off to a good start.
The famed desert fortress of Masada would prove a better test. A TV series and at least one movie focused on this historic last stand on the mountain top a couple thousand years ago cannot do this place justice. The mountaintop towers above its surroundings and is a challenging climb today. Of course there's a tram in place now that could save you the hike. Well, that is if everything goes right… With backpack loaded I reached the top. It's an area of roughly 36 acres with rock as both ground plus flooring in places. I stayed up top taking pictures with my son until they were closing the place down, pushing people out. "You must go!" shouted the guard as we headed back to the point of entry we'd used getting up there. But the guard is pointing the other way. We acknowledge his demand to get off the mountain top, but indicate we need to continue towards our chosen point of exit. "You must go, PLEASE!" Armed and animated, he wasn't exactly pleading. We comply, hiking down, down, down from the Byzantine gate hoping somehow there would be a shuttle back to my rental car. This is the first downhill test of the Lalo BUD/S Zodiac Recon AT. They had perfect traction and my foot was stable, not hitting the end of the toe box. That's great, but other things are on my mind.
For all practical purposes we're now stuck on the wrong side of Masada. There's no access to the primary side where my rental car, wife and daughter are. I check in with the guard there. "Who told you to come here?" they demand to know. So the same guy is conscripted to accompany us back up Masada so we can catch the tram car down. "You have fifteen minutes to be off Masada!" we are commanded. I don't like running to start with. Add my pack and the incline of a fortress that held off attackers forever and you can imagine my joy. Well, we make it up top and again I am thrilled with the performance of these tactical shoes. They prove grippy and stable on the rocky and often loose ground. If you ever plan on a high speed assault on Masada, I'd definitely recommend the Lalos as part of your kit.
Another day is spent running around the Judean desert filming epic sites like a monastery carved into deep cliff faces. My green shoes (aka, "Jungle") were turning white from the dust and now I have some sand in my feet as I headed for the Israel/Jordan border. I can't help but smile seeing the Israeli forces rocking Tavors, though in a different configuration than what we have here in the USA. Jordan makes country number three for my Lalos.
First stop in Jordan is Jarash. I have to say it's the strangest thing to see the epic columns of a Greek/Roman city standing against the background of Jordanian apartments, shops and daily life, literally across the street. I step into the ancient city through the same arch Emperor Hadrian walked through eons ago. Jarash is supposed to be the most well preserved town of it's kind. The full layout is intact, the stone columns still mostly standing. They estimate 25,000 people lived there back in the day. I'd hate to be wearing their sandals today!
Cue the Indiana Jones music, the next stop is Petra! Just like in the movie we make our way down the ancient river bed through the crack in the mountain and suddenly the face of the "Treasury" is revealed. Yeah, it is truly amazing, but I wanted to get to the Monastery, a steep hike up a million steps and some rugged terrain. Again, I was supper happy with how the Lalo's literally put some spring in my step.
New shoes, old city. Jarash, Jordan.
Back in the land of the Massod and Tavor I decide it's time to wash my shoes. I remove the insoles wash them out. Like my boots, the BUD/S Zodiac Recon AT's have drains but I'm not walking in them at this point. I'm kicked back checking email with the shoes on the porch of the West Bank Air BNB I've rented for the night. I should have checked the weather. It rains and my shoes are just as wet the next day. Happily, they don't smell bad.
I could go on and on. Two weeks in these from Jerusalem's old city to a Bedouin camp where I slept in Jordan, to Crusader walkways… And so much more. I start typing this BUD/S Zodiac Recon AT review on the plane flying home. I've been flying for a long time now and my feet are swollen. I've loosened the laces on my shoes as we descend towards Boston and my feet are fine. There's snow on the ground at my house so I'll put the Lalo's aside for a bit. At least until I get some that are better suited for snow.
My final Lalo BUD/S Zodiac Recon AT analysis after thoroughly testing them in the Middle East? Color me a convert, a convert to Lalo shoes that is.
The waters of Ein Gedi, where David hid out back in the OT.
This entry was posted in Special Hunting Weapons & Tactics™ - The Center of Gravity for Tactical and Long Range Hunting and tagged Boots, Footwear, Gear Review, Shoes, Tactical by Jonathan Owen. Bookmark the permalink.


text:
import {TextFieldModule} from '@angular/cdk/text-field';
import {CommonModule} from '@angular/common';
import {NgModule} from '@angular/core';
import {MatInputModule} from '@angular/material/input';
import {MatSelectModule} from '@angular/material/select';
import {
  TextFieldAutofillDirectiveExample
} from './text-field-autofill-directive/text-field-autofill-directive-example';
import {
  TextFieldAutofillMonitorExample
} from './text-field-autofill-monitor/text-field-autofill-monitor-example';
import {
  TextFieldAutosizeTextareaExample
} from './text-field-autosize-textarea/text-field-autosize-textarea-example';

const EXAMPLES = [
  TextFieldAutofillDirectiveExample,
  TextFieldAutofillMonitorExample,
  TextFieldAutosizeTextareaExample,
];

@NgModule({
  imports: [
    CommonModule,
    TextFieldModule,
    MatInputModule,
    MatSelectModule,
  ],
  declarations: EXAMPLES,
  exports: EXAMPLES,
})
export class CdkTextFieldExamplesModule {
}

redpajama_set_name: RedPajamaGithub


The Chinook's RAF role is explained by Ken Delve.
OF ALL THE ROLES examined in this series, that of the tactical helicopter has the most recent operational introduction, having a history of less than 40 years. Like a number of the other roles, this arose as a secondary consideration to the original concept for the operational employment of the helicopter. Helicopter development was slow and uncertain in the mid 1940s but by the late 1940s the Americans had taken the lead in this sphere.
Start of tactical missiles "Point" is made in the Kaliningrad region on the Baltic Fleet missile exercises, the press service of the Western Military District.
"A tactical missile, following the flight of a ballistic trajectory, successfully hit the command post of the imaginary enemy. Target accuracy was 97% damaged area — about 7 hectares, "- said the press service.
It notes that this is the first launch of tactical missiles "Point" in the Kaliningrad region for the past three years.
March 27 the Day of Russian Interior Ministry troops at the site of a separate division operational use in Balashikha (New Village) passed a comprehensive anti-terrorism special tactical exercises, with the participation of aircraft interior troops, units of a separate division of the operational purpose (Odon), and 604 soldiers On the center of a special purpose and the 33rd Special Forces "Relight" CRK MVD of Russia.
Gunners of the 58th Army of the Southern Military District (SOUTH) during tactical exercises with live fire in the camp at the site collection Tarskoe (Republic of North Ossetia — Alania) first used the unmanned aerial vehicle (UAV).
Aviation tactical high-speed anti-ship missile Kh-31AD is designed to destroy military (Airborne), surface ships and cargo ships from the battle groups (convoys) or the next single. In comparison with its prototype (X-31A) of the rocket increased by 15% power of the warhead. Firing range increased by almost 2-fold.


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text:
Archives|He Crossed Color Barrier, But In Another's Shadow
He Crossed Color Barrier, But In Another's Shadow
By IRA BERKOW FEB. 23, 1997
Larry Doby remembers clearly his first day in the major leagues, that day 50 years ago when he broke the color barrier in the American League. It was 11 weeks after Jackie Robinson had played his first game for the Brooklyn Dodgers in the National League. Doby remembers the excitement of that day when he became only the second black player in the major leagues -- he had hardly slept in four nights leading up to it -- and he remembers the dismay.
Saturday, July 5, 1947, a sunny morning in Chicago: Lou Boudreau, the manager of the Cleveland Indians, took the 22-year-old second baseman into the visiting team's locker room in Comiskey Park and introduced him to the players. Each of Doby's new teammates stood at his locker and looked over the young black man who had just been purchased by the Indians' owner, Bill Veeck, from the Newark Eagles of the Negro National League. Doby and the manager went from player to player.
''Some of the players shook my hand,'' Doby recalled recently, ''but most of them didn't. It was one of the most embarrassing moments of my life.''
As Major League Baseball and the nation prepare for a season of homage to the integration of the game, virtually all of the attention is centered on Jackie Robinson, which is understandable, since he was the first. Jackie Robinson commemorative coins, a Jackie Robinson video, a Jackie Robinson seminar.
''And that's the way it should be,'' Doby said. ''But Jack and I had very similar experiences. And I wouldn't be human if I didn't want people to remember my participation.''
Doby went through much the same kind of discrimination and abuse that Robinson suffered -- not being allowed to stay in the same hotels and eat in the same restaurants as the white players, hearing the racial insults of fans and opposing bench jockeys, experiencing the reprehension of some teammates.
But while Doby will be honored at the All-Star Game -- which, coincidentally, will be played in Cleveland on July 8 -- and at an Indians game a few days earlier, he in some ways seems the forgotten man.
''Jackie Robinson, of course, deserves all the credit he gets,'' Boudreau said last week. ''But I really don't think that Larry gets the credit he deserves for being the pioneer in the situation he was in.''
When the then-6-foot-1-inch, 185-pound Doby stepped onto the field before that first game with the White Sox, he stood silently in Cleveland uniform No. 14, glove in hand, for what he recalled as 5 or 10 minutes. ''No one offered to play catch,'' he said. Finally, he heard Joe (Flash) Gordon, the All-Star second baseman, call to him, ''Hey, kid, let's go.'' And they warmed up.
Doby, a left-handed batter, was called in to pinch-hit in the seventh inning and after ''hitting a scorching drive foul,'' according to a news-agency report, he struck out.
But he was officially a big-leaguer, one who the following year would help the Indians win the pennant and the World Series. He became the first black player to hit a home run in a World Series, made six straight American League All-Star teams and, at one time or another over a 13-year career, led the American League in homers, runs batted in, runs scored and slugging average, as well as strikeouts. When he retired in 1959, he did so with a .283 career average and 253 home runs.
About Robinson, Doby said: ''I had the greatest respect for Jack. He was tough and smart and brave. I once told him, 'If not for you, then probably not for me.' ''
Robinson and Doby were followed into the big leagues in 1947 by three other blacks: Henry Thompson and Willard Brown, who joined the St. Louis Browns in late July, and Dan Bankhead, who came up to the Dodgers in August. Thompson and Brown lasted for only a few weeks (though Thompson returned in 1949 to play several years with the New York Giants), while Bankhead pitched the rest of the season for the Dodgers.
Roy Campanella joined the Dodgers in 1948 and Don Newcombe made it in 1949. Today, Major League Baseball estimates that about one-third of its players are black or Hispanic, but in 1950, three years after Robinson and Doby broke the color barrier, only five major league teams had been integrated. By 1953 there were 20 blacks on 7 of the 16 teams. And it was not until 1959, when the Boston Red Sox played Pumpsie Green, that every major-league club had a black player.
Lou Brissie, who pitched for the Philadelphia A's beginning in 1947, recalled: ''I was on the bench and heard some of my teammates shouting things at Larry, like, 'Porter, carry my bags,' or 'Shoeshine boy, shine my shoes,' and, well, the N-word, too. It was terrible.''
Brissie, who was from South Carolina, had been shot and left for dead in Italy during World War II. He pitched with a large steel brace on his left leg and instinctively felt an identity with the young black player. ''He was a kind of underdog, like me,'' Brissie said.
Doby has not forgotten the abuse: the ''N-word'' being used every day, the calls of ''coon'' and ''jigaboo,'' the times he slid into second base and the opposing infielder spit in his face.
''I never sought sympathy or felt sorry for myself,'' Doby said. ''And all that stuff just made me try harder, made me more aggressive. Sometimes I'd get too aggressive, and swing too hard, and miss the pitch.''
But he cannot forget the sense of loneliness, particularly after games. ''It's then you'd really like to be with your teammates, win or lose, and go over the game,'' he said. ''But I'd go off to my hotel in the black part of town, and they'd go off to their hotel.''
Doby is now 72, his hair sprinkled lightly with gray. He is huskier than in the old photos of him breaking in with the Indians. He works for Major League Baseball, handling the licensing of former players. Wearing a tie and suspenders and an easy smile and forthright manner, this father of five, grandfather of six and great-grandfather of three reflected on his years as a ballplayer as he sat recently in a sunny 29th-floor room at the Baseball Commissioner's office in Manhattan.
''When Mr. Veeck signed me,'' Doby said, ''he sat me down and told me some of the do's and don'ts. He said, 'Lawrence' -- he's the only person who called me Lawrence -- 'you are going to be part of history.' Part of history? I had no notions about that. I just wanted to play baseball. I mean, I was young. I didn't quite realize then what all this meant. I saw it simply as an opportunity to get ahead.
''Mr. Veeck told me: 'No arguing with umpires, don't even turn around at a bad call at the plate, and no dissertations with opposing players; either of those might start a race riot. No associating with female Caucasians' -- not that I was going to. And he said remember to act in a way that you know people are watching you. And this was something that both Jack and I took seriously. We knew that if we didn't succeed, it might hinder opportunities for other Afro-Americans.''
Doby had been leading the Negro National League in batting average, at .415, and home runs, with 14, when he was signed by the Indians. He began as a second baseman, but was switched to the outfield, where he would be assured of starting. But he was unaccustomed to playing there, and in an early game, in center field, and with the bases loaded, he misjudged a fly ball in the sun and the ball hit him on the head. It caused his team to lose the game.
After the game, Bill McKechnie, an Indian coach who had befriended Doby, said to him, ''We'll find out what kind of ballplayer you are tomorrow.'' Doby recalled that McKechnie smiled. ''It was a challenge and a kind of vote of confidence,'' Doby said. ''The next day I hit a home run to win the game.''
Doby appreciated Gordon and McKechnie and the catcher, Jim Hegan, in particular, who would seek to salve his disappointments and perhaps take a seat next to him after he had struck out or made an error.
''They were tremendous,'' Doby said. ''But there were others who don't remember, or don't want to remember, some of their actions. And sometimes I'd see them later and they'd say, 'Hey, Larry, let's go have a beer.' I thought, 'When I needed you, where were you?' I forgive, but I can't forget. I politely decline their invitations.''
Doby spent his grammar-school years in Camden, S.C. He recalls seeing the white people riding in fringed horse-drawn buggies through the black neighborhood, and tossing dimes and nickels at the small black children. And then they would rub the children's heads for good luck. ''My grandmother warned me never to pick up the money,'' Doby said. ''She thought it was undignified.
''And then I always tried to act in a dignified manner. When I was in the major leagues, some people thought I was a loner. But, well, when Joe DiMaggio was off by himself, they said he just wanted his privacy. And midway through the 1948 season the Indians signed Satchel Paige, and they made him my roommate. Well, he was almost never in the room. I'm not sure where he went. But he was a character and he enjoyed being perceived that way. He'd come into the clubhouse and clown around, and did some Amos 'n' Andy stuff. I didn't think it was right -- at least, it wasn't right for me.''
Eddie Robinson, the Indians' first baseman when Doby broke in, said by telephone from his home in Fort Worth: ''I thought it took a lot of courage for Larry to go through what he did. He handled himself quite well.''
But when Boudreau put Doby at first base to start the second half of a doubleheader on Doby's second day in the major leagues, Robinson would not let him use his glove. ''I didn't want anyone else playing my position, and it had nothing to do with black or white,'' Robinson said. As Doby recalls, the Indians were able to borrow a first baseman's glove for him from the White Sox.
Doby had been the only black player on the Eastside High School baseball, football and basketball teams in Paterson, N.J.. He went briefly to Long Island University and Virginia Union before being drafted into the Navy. He first learned of Jackie Robinson's signing with the Dodgers' organization when he was on a Pacific Island in 1945.
''I wondered if I might have a chance to play in the big leagues, too,'' Doby said. ''Until then, I thought I would just go back to Paterson and become a high-school coach.''
Doby gives talks at schools, and discusses the changes in American life. ''I know people are critical and say that not enough progress has been made in baseball, or sports in general, particularly in the coaching or administrative levels,'' he said. ''And I believe there has not been enough progress made either. But when you look at other elements of American society, then sports stacks up pretty good. If Jack and I had a legacy, it is to show that teamwork -- the ability to associate and communicate -- makes all of us stronger.''
In 1978, Doby was named manager of the White Sox, taking over for Bob Lemon midway through the year. He held the position for just 87 games, posting a record of 37-50.
''I was the second black manager in major league history,'' Doby said, ''after Frank Robinson.''
Frank Robinson managed the Indians starting in 1975.
''Funny thing,'' Doby said, with a smile, ''I followed another Robinson.''
A version of this article appears in print on February 23, 1997, on Page 1001001 of the National edition with the headline: He Crossed Color Barrier, But In Another's Shadow. Order Reprints| Today's Paper|Subscribe


text:
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Analysis on access to a lawyer during the first hours of custody in Mexico
The APT is pleased to announce the publication of its new document "Access to a lawyer during the first hours of custody in Mexico - A Situation Analysis". The document analyses the implementation of the right of access to a lawyer in the first hours of detention in Mexico, identifying the main obstacles and gray areas as well as ways forward that may contribute to reduce the gap between law and reality.
The study was carried out between August and December 2018, as part of a project that seeks to contribute to closing the gap that exists between law and practice in Mexico and to guarantee that all persons deprived of liberty have access to a lawyer in the first hours of detention. The document focuses on the first hours of custody and, in particular, on arrests in flagrante delicto, that is, from the moment the police and the Public Prosecutor's Office detain a person until he or she is brought before the judge. In particular, the study focused on the implementation of the right of access to a lawyer in Mexico City and in the states of Nuevo León and Oaxaca.
The methodology used for the study included a desk review, questionnaires addressed to the 32 State Public Defender's Offices of the country and interviews with key actors, including authorities, human rights institutions and civil society. Together with the National Preventive Mechanism (NPM), an expert meeting was also held in November 2018 in Mexico City, whose conclusions are included in the present study. The event brought together a wide range of participants from several Mexican states, including public defenders, public prosecutors, representatives of the NPM, civil society organizations, judges, representatives of law enforcement agencies and state human rights commissions. .
Based on this study, in the following months the APT will continue to promote the effective implementation of the right of access to a lawyer in Mexico. A partir de este análisis, en los próximos meses la APT seguirá trabajando para promover la implementación efectiva del derecho de acceso a un/a abogado/a en México.
The APT conducted this study as part of a project funded by the Ford Foundation.


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Museum |
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Friends of Photography Association
Museum Structure and Management
Kadırga, a neighborhood which holds a special place in Istanbul's historical landscape and where palaces and select settlements existed during the Byzantine and Ottoman periods, is home to Turkey's first photography museum.
The Museum was established as a result of collaboration with Fatih Municipality whom allocated the Museum's one thousand meter square building. The Museum, which has been photographers' dream for many years, is managed and administered by the Friends of Photography Association
The Museum hopes to bring to Istanbul a brand new cultural service by providing exhibitions, collections, publications, photography archives, electronic and standard libraries, activities, and educational projects to further develop the Turkish art of photography.
Copyright © 2011-2014 FB – FDD | Legal Disclaimer


Grateful for the outpouring of support from the community; from messages of encouragement to artists offering to help me repaint, to people wanting to donate their time and resources to restore the mural. It is really touching to see Houston come together like this. The intent of the BeVisible mural was to create a space that fosters community and acceptance, a place where ANYONE could come and feel inspired and I think it achieved that.
This mural is a broad representation of a Pride Flag and the variation in sections represent the diversity in our communities.
Below are some photos from friends of the Pride Wall.


Your plan is what ties all of these things together. Without a plan to execute your entry strategy or risk management or money management there is no way a will be successful. I offer Forex coaching because I want to save you the time and money that I and so many other traders lose trying to figure out how to trade the markets. I've delivered my Forex coaching course to people in over 58+ Countries around the world & I would like to help you to. To get started join me on a free webinar. Emerging currencies have swung wildly in 2018 as investors fled stock and bond markets, fretting that higher global borrowing costs could squeeze economic growth and even lead to debt defaults. What is the best forex trading robot available today? Trade – The ratio of export vs import prices leads to the balance of payments. Higher exports (than imports) means the country's goods are in demand leading to an increase in their currency which is needed to pay for their good. The Team Trading Markets There are many added complexities to the trading environment and there can be an increased risk. As we take a parallel position in the underlying market, DMA traders need to be aware that once an order has been executed we are unable to change or reverse the position.


Home > Patients & Visitors > Health Library > Hair Loss: Should I Take Medicine to Regrow Hair?
Use medicine to help stop hair loss and possibly regrow new hair.
Do not use medicine to treat hair loss.
This decision aid is about whether to use medicine to treat hair loss. It doesn't discuss hair transplant surgery.
Treatment with medicines may slow hair loss and help to regrow hair. But you may not get as much hair growth as you expect.
You must keep taking the medicine, or any regrown hair will fall out.
Your insurance probably will not cover the medicine, and the medicines can be costly.
It may be very dangerous to take these medicines if you are pregnant or have certain health conditions, such as heart problems.
You may feel that the possibility of regrowing hair and feeling better about how you look is more important than the limitations of hair loss treatment.
What medicines are available to treat inherited hair loss?
Minoxidil. Minoxidil (Rogaine) is available without a prescription. You spray or rub it into your scalp 2 times a day. It can be used by both men and women.
Finasteride. Finasteride (Propecia) is available by prescription. It's a pill that you take once a day. It can be used by men.
Medicine for treating inherited hair loss slows thinning of the hair and increases coverage of the scalp by growing new hair. It also thickens the shafts of your existing hair so that it grows in thicker.
With these medicines, hair coverage tends to improve on the top of the head but not on the forehead area.
How effective are these medicines in treating inherited hair loss?
Finasteride and minoxidil (for men) and minoxidil (for women) have the best level of evidence for medicines used to treat inherited hair loss.footnote 1, footnote 2 How well finasteride or minoxidil works depends on your age and the location of the hair loss. These medicines don't work for everyone, and you should not expect to regrow a full head of hair.
Both medicines must be used daily. It may take 6 months of treatment before you see results.
These medicines slow thinning of the hair and increase coverage of the scalp by growing new hair. They also thicken the shafts of your existing hair so that it grows in thicker. If you stop using the medicine, any hair that has grown in will gradually be lost. Within 6 to 12 months after you stop using the medicine, your scalp will most likely look the same as it did before treatment.
Side effects of minoxidil include skin irritation, dandruff, and an itchy scalp. In women, minoxidil may cause facial hair growth, especially on the forehead and cheeks. If you have heart problems, ask your doctor before you use this medicine.
Finasteride should not be taken or handled by women who are or may become pregnant, because it can cause birth defects. Possible side effects in men include sexual problems, such as trouble getting an erection.
What are the disadvantages of using these medicines?
The medicines may not work. You should not expect to regrow a full head of hair. It may take from a few months to a year before you see results.
You must take the medicine every day. If you stop, any regrown hair will fall out, and you will end up with the same amount of hair you had when you started treatment.
The medicines are costly and usually aren't covered by insurance.
What are the risks of not using these medicines?
There are no risks to your health if you decide not to use medicine for hair loss. But some people may be bothered by hair loss that they feel has affected their appearance.
If you don't use medicine, your hair loss will probably continue. But medicine doesn't always work, and hair loss may continue despite treatment with medicine.
You take or apply medicine every day to stop hair loss and to try to regrow hair.
Medicine can stop hair loss and may lead to new hair growth. This may help some people feel better about the way they look.
Finasteride should not be taken or handled by women who are or may become pregnant. It can cause birth defects. Side effects in men may include sexual problems.
Side effects of minoxidil include skin irritation, dandruff, and an itchy scalp. In women, minoxidil may cause facial hair growth.
Hair loss medicines may have serious side effects when taken with other medicines or if you are pregnant or have health conditions such as a heart problem.
The medicine may not work.
It can take a few months or a year to see any results.
If you stop taking the medicine, the regrown hair will fall out, and you will end up with the same amount of hair you had when you started treatment.
You do nothing to treat the hair loss, or you think about other choices, such as surgery or hairpieces.
You won't have to pay for medicine to treat the hair loss.
You won't have the risk of side effects from the medicine.
You may continue to lose your hair. This may affect the way you feel about the way you look.
My father and grandfather are both bald. I decided to use Rogaine to see if it would slow down my hair loss. I don't want to look like my dad just yet!
My hair began to thin when I was 28 years old. Now I am 44 and the top of my head is bald. Recently, I considered using medicine to treat my hair loss and see if any hair would regrow. After reading the literature and talking to my doctor, I decided not to take medicine because it is unlikely to make a huge difference in my hair—and I don't want to take medicine forever!
My hair is very important to me and my appearance. I noticed that my hair was starting to thin. And because baldness runs in our family, I decided to take an aggressive approach to reduce my chances for more hair loss. I am willing to take a pill every day, and to pay for it.
I have noticed some thinning throughout my scalp. Although this is disturbing to me, I have decided not to take medicine for the hair loss. It seems that medicine works best for young males. So now I'm checking out hair transplant surgery. I think that in the long run, I may be happier with the results.
My hair loss causes me a lot of stress or unhappiness.
My hair loss doesn't bother me too much.
I am willing to pay for the treatment over the long term.
I do not want to pay for treatment over the long term.
I realize that the treatment may not work for me, but I want to try it anyway.
I don't want to try the treatment if there is a chance it won't work.
I will be happy if I can stop the hair loss and some hair grows back.
Using medicine will only be worth it to me if I will have a full head of hair.
Taking medicine to treat the hair loss.
NOT taking medicine to treat the hair loss.
1.1, If I use medicine to treat my hair loss, I will end up with a full head of hair.
TrueNo, that's not right. The medicines don't always work. And if they do, you may not get as much hair growth as you expect. Hair coverage tends to improve on the top of the head but not on the forehead area.
FalseThat's right. The medicines don't always work. And if they do, you may not get as much hair growth as you expect. Hair coverage tends to improve on the top of the head but not on the forehead area.
I'm not sureIt may help to go back and read "Get the Facts." The medicines don't always work. And if they do, you may not get as much hair growth as you expect.
2.2, If I stop taking the medicine, my new hair growth will fall out.
TrueThat's right. You must take the medicines every day, over the long term. Otherwise, any regrown hair will fall out, and you will end up with the same amount of hair you had when you started treatment.
FalseNo, that's not right. You must take the medicines every day, over the long term. Otherwise, any regrown hair will fall out, and you will end up with the same amount of hair you had when you started treatment.
I'm not sureIt may help to go back and read "Get the Facts." You must take the medicines every day, over the long term. Otherwise, any regrown hair will fall out.
3.3, I should check with my doctor before I take hair loss medicines.
TrueThat's right. You should talk with your doctor before you take hair loss medicines. These medicines may cause serious side effects if you take them with other medicines, are pregnant, or have certain health conditions.
FalseNo, that's not right. You should talk with your doctor before you take hair loss medicines. These medicines may cause serious side effects if you take them with other medicines, are pregnant, or have certain health conditions.
I'm not sureIt may help to go back and read "Get the Facts." You should talk with your doctor before you take hair loss medicines.
Varothai S, Bergfeld WF (2014). Androgenetic alopecia: An evidence-based treatment update. American Journal of Clinical Dermatology, 15(3): 217–230. DOI: 10.1007/s40257-014-0077-5. Accessed February 6, 2018.
Van Zuuren EJ, et al. (2015). Interventions for female pattern hair loss. Cochrane Database of Systematic Reviews (5). DOI: 10.1002/14651858.CD007628.pub4. Accessed February 12, 2018.
Finasteride and minoxidil (for men) and minoxidil (for women) have the best level of evidence for medicines used to treat inherited hair loss.1, 2 How well finasteride or minoxidil works depends on your age and the location of the hair loss. These medicines don't work for everyone, and you should not expect to regrow a full head of hair.
"My father and grandfather are both bald. I decided to use Rogaine to see if it would slow down my hair loss. I don't want to look like my dad just yet!"
"My hair began to thin when I was 28 years old. Now I am 44 and the top of my head is bald. Recently, I considered using medicine to treat my hair loss and see if any hair would regrow. After reading the literature and talking to my doctor, I decided not to take medicine because it is unlikely to make a huge difference in my hair—and I don't want to take medicine forever!"
"My hair is very important to me and my appearance. I noticed that my hair was starting to thin. And because baldness runs in our family, I decided to take an aggressive approach to reduce my chances for more hair loss. I am willing to take a pill every day, and to pay for it."
"I have noticed some thinning throughout my scalp. Although this is disturbing to me, I have decided not to take medicine for the hair loss. It seems that medicine works best for young males. So now I'm checking out hair transplant surgery. I think that in the long run, I may be happier with the results."
1. If I use medicine to treat my hair loss, I will end up with a full head of hair.
That's right. The medicines don't always work. And if they do, you may not get as much hair growth as you expect. Hair coverage tends to improve on the top of the head but not on the forehead area.
2. If I stop taking the medicine, my new hair growth will fall out.
That's right. You must take the medicines every day, over the long term. Otherwise, any regrown hair will fall out, and you will end up with the same amount of hair you had when you started treatment.
3. I should check with my doctor before I take hair loss medicines.
That's right. You should talk with your doctor before you take hair loss medicines. These medicines may cause serious side effects if you take them with other medicines, are pregnant, or have certain health conditions.
Varothai S, Bergfeld WF (2014). Androgenetic alopecia: An evidence-based treatment update. American Journal of Clinical Dermatology, 15(3): 217-230. DOI: 10.1007/s40257-014-0077-5. Accessed February 6, 2018.


text:
Q: how to check if a different values are greater than different data frame rows in R? I have a data frame
df1   =data.frame(a=c(100,200,150,NA),
                 b=c(300,40,90,30),
                 c=c(12,500,1000,2))

df2 = data.frame(s= c(150,300,80,15))

I need to check whether the values of df1 are greater than df2$s wrt rows.
For ex. 150 will be compared to 1st row i.e. (100,300,12) of df will result in (F, T, F).
Similarly 300 to 2nd row and so on
Required Output
result_df =  data.frame(a=c(F,F,T,F),
                        b=c(T,F,T,T),
                        c=c(F,T,T,F))

it can be done in the loop, but is there any faster approach?

A: We can replicate to make the lengths same and do the comparison
df1 > df2[row(df1)] & !is.na(df1)

-output
      a     b     c
[1,] FALSE  TRUE FALSE
[2,] FALSE FALSE  TRUE
[3,]  TRUE  TRUE  TRUE
[4,] FALSE  TRUE FALSE

Or may also extract the column from 'df2' and directly do the comparison
df1 >df2$s & !is.na(df1)

redpajama_set_name: RedPajamaStackExchange


The following guidance pertains to the Countering America's Adversaries Through Sanctions Act of 2017 ("CAATSA" or "the Act") (Pub. L. 115-44), which was adopted by the U.S. Congress July 28, 2017 and signed by President Trump August 2, 2017. The Administration will fully implement the Act consistent with the overall national security and foreign policy interests of the United States, as well as our specific policies regarding Russia and its external activities.
On September 29, 2017, President Trump delegated the authority to implement Section 231 to the Secretary of State, in consultation with the Secretary of the Treasury. Section 231 requires the imposition of certain sanctions on persons determined to have knowingly engaged in a significant transaction, on or after the date the Act was enacted, with a person that is part of or operating for or on behalf of the defense or intelligence sectors of the Government of the Russian Federation.
Pursuant to Section 231(d), the Department of State on October 27, 2017, issued guidance to specify persons that are part of, or operating for or on behalf of, the defense or intelligence sectors of the Government of the Russian Federation ("Section 231 Guidance" or "the Guidance").
The Guidance names certain persons, but it is not a determination regarding imposition of sanctions. No asset freezes are being imposed on these named persons as a result of their inclusion in this Guidance, and inclusion in this Guidance does not, of itself, mean such persons are added to the Department of the Treasury's List of Specially Designated Nationals List and Blocked Persons or Sectoral Sanctions Identification List.
The Act requires the imposition of five or more sanctions of the twelve listed in Section 235 of the Act beginning on or after January 29, 2018, with respect to persons determined to have engaged in conduct covered by this Section since enactment of the Act August 2, 2017. Such determinations will be made in a separate notice.
persons – which can be individuals or entities – that are part of, or operating for or on behalf of, the defense or intelligence sectors of the Government of the Russian Federation. This Guidance was developed, and may in the future be amended or updated as circumstances warrant, based on a robust interagency process.
A: No. Specification in this Guidance only indicates that an individual or entity has been identified as part of, or operating for or on behalf of, the defense or intelligence sectors of the Government of the Russian Federation, for purposes of implementing Section 231(d). Some of the individuals or entities named, however, may also be currently subject to U.S. sanctions imposed under other authorities.
A: No. The Act states that sanctions shall be imposed beginning on or after 180 days after enactment on persons that are determined to knowingly engage in a significant transaction with a person specified in the Guidance on or after the date of enactment of the Act.
A: In determining whether a transaction is "significant" for purposes of section 231 of the Act, the Department of State will consider the totality of the facts and circumstances surrounding the transaction and weigh various factors on a case-by-case basis. The factors considered in the determination may include, but are not limited to, the significance of the transaction to U.S. national security and foreign policy interests, in particular whether it has a significant adverse impact on such interests; the nature and magnitude of the transaction; and the relation and significance of the transaction to the defense or intelligence sector of the Russian government.
In this initial implementation stage, our focus is expected to be on significant transactions of a defense or intelligence nature with persons named in the Guidance. If a transaction for goods or services has purely civilian end-uses and/or civilian end-users, and does not involve entities in the intelligence sector, these factors will generally weigh heavily against a determination that such a transaction is significant for purposes of Section 231.
If a transaction is necessary to comply with rules and regulations administered by the Federal Security Service, or law enforcement or administrative actions or investigations involving the Federal Security Service, including rules and regulations administered by the Federal Security Service for the importation, distribution, or use of information technology products in the Russian Federation and the payment of any fees to the Federal Security Service for such licenses, permits, certification, or notifications, then these factors will weigh heavily against a determination that that such transaction is significant for purposes of this section.
A: The Act provides for certain sanctions, including on U.S. persons, in the event of a significant transaction. The Act does not provide for sanctions in cases in which transactions are not "significant." Where possible, the United States intends to work with persons considering transactions with persons named in this Guidance to help them identify and avoid engaging in potentially sanctionable activity.
A: In implementing Section 231, the Department of State is mindful of the importance of unity and coordination with our allies and partners on these issues. The Act itself acknowledges the importance of these relationships, and these purposes, when providing in Section 212 that we "should continue to uphold and seek unity with European and other key partners on sanctions implemented against the Russian Federation, which have been effective and instrumental in countering Russian aggression in Ukraine." Where possible, the United States intends to work with our allies and partners to help them identify and avoid engaging in potentially sanctionable activity while strengthening military capabilities used for cooperative defense efforts.
United States government procurement prohibitions. The Act allows for sanctions on persons that engage in covered transactions as well as on the principal executive officer or officers of the sanctioned person (or a person performing similar functions and with similar authorities as such officer or officers).
A: Transactions with persons not listed in this Guidance are not currently the focus of our Section 231 implementation efforts.


Not too long ago, Suzuki had announced that it will officially pull the plug on its signature superbike, the Hayabusa, in Europe. The decision was taken by the Japanese marque in accordance with the European emission norms, according to which, all new bikes which go on sale in Europe from 1st January 2019 must comply with the Euro-IV emission norms, a criterion which the current Hayabusa does not meet.
However, we had informed our readers that the bike will continue to sell in India since it meets the BS-IV emission norms. And now, Suzuki has launched the 2019 iteration of the mega bike in India. While the 2019 model remains identical to the outgoing model in terms of its mechanicals, the new model will be offered in two new colour schemes – Metallic Oort Grey and Glass Sparkle Black. For added appeal, the grey-colour bike gets maroon-colour wheels and a Japanese decal of the name finished in the same shade. Meanwhile, the black colour option gets silver wheels and decal.
The 2019 model, like its predecessor, continues to be powered by a ballistic 1,340cc inline-four engine which produces 197bhp and 155Nm of torque. What still makes it an absolute beast is the fact that other than the ABS, the bike features no other fancy electronic aid, thereby making it a thoroughbred. The Hayabusa will continue to sell as CKD in India and carries a price tag of ₹ 13.74 lakh (Ex-showroom, Delhi).