The World of Wellesley and the Wellesley Community Center are excited to sponsor the third annual Wellesley Community Book read, The Color of Law –The Forgotten History of How Our Government Segregated America by Richard Rothstein.
World of Wellesley invites community organizers and neighborhood book groups to join and support this book discussion, community conversation and author visit.
The goal is for organizations and book groups to discuss Rothstein's book in their own settings over the next few months. We will then gather on March 26th at the Wellesley Community Center for a community presentation and conversation with Rothstein. Chuck Collins, author of Born on Third Base, which was last year's Community Read, will be on hand as a special guest and moderator.


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News Release 17-Dec-2020
US needs clear vaccine distribution strategy to defeat coronavirus
Columbia University's Mailman School of Public Health
Research News Release
An opinion piece published today online calls for a national vaccine strategy now that COVID-19 vaccines are available. The author writes that a lack of clarity on a distribution plan sets unrealistic expectations among the public and could undermine public trust. But even with a clearly defined strategy in place, vaccinating hundreds of millions of Americans will not be easy.
News Release 9-Dec-2020
Big data offers promise of better groundwater management in California
A McGill University-led research team has analyzed big data of more than 200,000 groundwater samples taken from across the state and found that there are problems with the guidelines used for groundwater management. Known as the 'Base of Fresh Water', the guidelines are close to fifty years old and don't reflect current uses, knowledge, concerns or technologies related to managing groundwater in this coastal state with a multi-billion-dollar agricultural industry.
Natural Sciences and Engineering Research Council
Higher frequency of financial reporting hinders corporate innovation
Research shows that more regular financial reporting increases managerial myopia and stifles innovation.
Journal of Law and Economics
Deciphering the energetic code of cells for better anticancer therapies
A procedure that may help personalise anticancer therapies has just been developed by the CNRS, INSERM, and Aix-Marseille University scientists in association with colleagues from the University of California San Francisco and the Marseille Public University Hospital System (AP-HM), with support from Canceropôle Provence-Alpes-Côte d'Azur. Their patented technique reveals the energy status of cells, an indicator of their activity.
News Release 15-Oct-2020
A review of public comments on a proposed FDA regulatory framework, for modifications to artificial intelligence and machine learning-based software as a medical device, has found that 63% came from parties with financial ties to industry, and that the majority, 86% did not cite any scientific evidence.
National Institute for Health Research (NIHR), Oxford Biomedical Research Centre (BRC)
Foreign election interference: A global response
Mary Ann Liebert, Inc./Genetic Engineering News
The increasing threat of foreign interference in elections has driven six nations to take similar approaches to combat this pervasive threat. A review of the details to their responses brings out valuable differences and insights.
Election Law Journal: Rules, Politics, and Policy
News Release 21-Sep-2020
CU Denver researcher analyzes the use of solar energy at US airports
By studying 488 public airports in the United States, University of Colorado Denver School of Public Affairs researcher Serena Kim, PhD, found that 20% of them have adopted solar photovoltaic (PV), commonly known as solar panels, over the last decade.
ARPA-type funding gives green technology an 'innovation advantage', study finds
Startups funded by US energy agency ARPA-E file patents at twice the rate of similar cleantech firms, according to latest research. UK should trial its own climate-focused ARPA as part of Covid-19 recovery package, argues Cambridge researcher. Learn lessons from US by supporting startups through "valley of death" to boost productivity and innovation in green tech.
Nature Energy
News Release 7-Aug-2020
SFU chemist's new process fast-tracks drug treatments for viral infections and cancer
Discovering antiviral and anticancer drugs will soon be faster and cheaper thanks to new research from Simon Fraser University chemist Robert Britton and his international team.
News Release 30-Jul-2020
Investment, health policy changes are key for new Alzheimer's treatments
Two new USC reports describe a challenging obstacle course for patients to access Alzheimer's disease treatments once they become available.
Alzheimer's Association International Conference
Roche/Genentech
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redpajama_set_name: RedPajamaCommonCrawl


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redpajama_set_name: RedPajamaGithub


The crystal measures 10mm in diameter and is a stunning shade of siam red (January Birthstone colour). It is facet cut to give it an amazing radiance and shine. A beautiful look for everyday wear or layer with other pendants for a more striking style.


To determine the feasibility and acceptability of lower limb neuromuscular electrical stimulation (NMES) as a home-based exercise therapy in patients with cancer who could not attend hospital-based exercise training.
A single-arm prospective pilot study of NMES, applied daily to both quadriceps muscles for six weeks. Participants were recruited from patients referred to a hospital-based multi-disciplinary supportive care team specializing in treatment of patients with nutritional depletion and functional decline.
Of the 15 participants who underwent baseline testing, 10 (67%) completed the study and only one (7%) withdrew because of discomfort due to NMES treatment. 7/10 (70%) of participants used NMES at least three times a week for the duration of the study. Use of NMES did not lead to significant improvements in physical performance tests.
NMES is a feasible and acceptable intervention for home use in patients with cancer, poor performance status and metastatic disease. However, whether NMES is an effective strategy to stabilize or improve physical performance in such patients is not proven.
Patients with cancer frequently suffer problems common to other chronic diseases, namely long-lasting sequelae from their disease and its treatments  as well as progressive decline in overall functional status [2, 3]. In many chronic medical conditions e.g. chronic obstructive pulmonary disease (COPD), and congestive heart failure (CHF), exercise-based rehabilitation programs have a major impact on quality of life and functional status  and are widely deployed as part of standard clinical care. However, despite growing evidence that exercise training in cancer patients also contributes to improved quality of life and tolerance of anti-cancer treatment , exercise-rehabilitation has not been generally adopted for patients with cancer.
Exercise training programs for patients with chronic diseases typically involve hospital-based supervised training two or three times a week. However, attendance at hospital-based exercise training is difficult for debilitated patients with cancer; and though patients with advanced cancer are willing to exercise they strongly prefer to do so at home [6, 7]. However the beneficial impact of such home-based training is still unclear and is difficult to measure. For example, a recent study of home-based semi-supervised exercise was unsuccessful because of unexpected poor accrual and high dropout rates . Outside of such studies, community or home-based supervised training is often not readily available for patients with medical conditions. Thus by default, a self-directed unsupervised home exercise program is often recommended for patients unable or unwilling to attend hospital training, despite the inherent difficulties in monitoring exercise adherence and intensity. Other approaches are therefore needed which can deliver a safe and effective exercise stimulus at home, in a manner which is suitable for use by patients with poor physical function.
Neuromuscular electrical stimulation (NMES) delivers a controlled contractile stimulus to underlying muscles via surface electrodes placed on the skin. It is widely used for rehabilitation of neurological or orthopedic conditions. NMES is often used to assist with rehabilitation following joint surgery , by helping to speed up the recovery of muscle strength and joint function. Moreover, NMES used in conjunction with voluntary contraction exercises, accelerates leg muscle strengthening after knee arthroplasty . More recently NMES has been assessed for patients suffering chronic medical conditions. In debilitated patients with COPD or CHF, NMES of the large lower limb muscles was shown to increase muscle size , improve muscular strength and overall exercise capacity [12–14], facilitate activities of daily living, and improve quality of life .
Despite the evidence for effectiveness of NMES in other patient populations, relatively few studies have been performed to test the potential usefulness of NMES in patients with cancer. One case study reported use of NMES in a single patient with extensive metastatic lung cancer, who achieved improvements in mobility, function and quality of life with NMES . Another pilot study used NMES in a randomized trial involving 16 advanced stage non-small cell lung cancer patients with good performance status. Those receiving NMES found it highly acceptable, but there was only a non-significant trend towards improvement in leg muscle strength or other measures of endurance and habitual daily activity . In a follow-up phase II study, the same authors recruited lung cancer patients undergoing first-line palliative chemotherapy and randomized them to NMES intervention (30 patients) or a control (19 patients) group . In this later study there was no improvement in the physical function tests (quadriceps strength or physical activity), and a lower than expected level of adherence. As a result, the authors concluded that NMES does appear to warrant further study in advanced lung cancer patients at this stage in their treatment . This does not rule out a role for NMES to reduce muscle loss and dysfunction  in other patients with cancer, but to date there is still little published data on the use of NMES in patients with cancer in general, especially those with poor performance status.
The McGill Cancer Nutrition-Rehabilitation Program clinic at the Jewish General Hospital (CNR-JGH clinic) in Montréal, is a multi-disciplinary team that specifically addresses the clinical needs of patients with cancer referred with weight loss, anorexia, and reduced physical function. The CNR-JGH clinic uses a comprehensive interdisciplinary approach to assess and control symptoms, along with individualized dietary interventions and exercise training wherever possible. In our experience, hospital-based exercise training is very difficult to deliver to patients with poor performance status and those who live far away from the hospital. To address this practical problem, a pilot study was performed to evaluate the acceptability and feasibility of a home-based NMES intervention in a heterogeneous group of patients attending the CNR-JGH clinic, the majority of whom had advanced stage cancer. The secondary objective of the study was to assess the impact of the NMES intervention on tests of physical function focused on walking endurance capacity, lower extremity strength and global functional performance.
Patients were recruited from those referred to the CNR-JGH clinic for consultation by their treating oncology teams at the Jewish General Hospital: an urban university teaching hospital in Montréal, Québec, Canada. The participants recruited included both those with impaired performance status (PS = 2 or 3)  and patients with better performance who were unable to attend hospital-based supervised physical rehabilitation more than once a week due to travel distance or other similar constraints. Patients were excluded if they had any cognitive impairment affecting their ability to apply NMES safely without medical supervision, skin conditions contraindicating repeated use of surface electrodes, orthopedic implants in the hip joint, metastatic lesions to the femur, or electronic implants (e.g., pacemakers and defibrillators). Patients who were already actively participating in a supervised rehabilitation or exercise intervention greater than once a week were also ineligible.
All assessments, instruction and follow-ups were performed by the study physiotherapist in the CNR-JGH clinic. Baseline functional evaluation was performed as follows: a) Walking endurance capacity was assessed with the 6-minute walk test (6 MWT) . If patients were unable to walk independently even with standard walking devices (including rolling walking frames) a score of 0 m was recorded. b) Lower extremity functional strength was assessed using the repeated Sit-to-Stand (STS) test, as included in the Simmonds Functional Assessment Battery . The patient was instructed to go from sitting to standing twice in a row as quickly as possible, without the use of their arms. The test was performed twice and the average time of the two trials was recorded. c) Global functional performance status (PS)  was recorded based on patient's report of their level of physical activity to the study physiotherapist.
Participants were instructed on the application of the surface electrodes and the use the portable NMES machine (Neurotech MediStim, Galway, Ireland). Initial training was performed to ensure that participants were able to apply the electrodes and use the device on themselves without additional assistance. After cleaning the skin with an alcohol pad, disposable electrodes (EMPI Self-adhesive Carbon FM electrodes 2"x 2") were applied to the motor points of the Vastus Medialis Oblique distally, and over the midpoint of the quadriceps muscle belly more proximally . The electrodes placed on each thigh were then connected to the individual leads of the NMES unit, to allow for separate intensity control for each quadriceps. Participants were instructed to use NMES at home for 6 weeks on both quadriceps muscles simultaneously for 30 minutes a day. Stimulation parameters were as follows: 300 ms pulses, 50 Hz, alternating 5 s on 5 s off (50% duty). Stimulation intensity was individually adjusted for each limb in order to obtain tetanic contraction or maximum tolerated intensity. In addition, participants were instructed to voluntarily contract the quadriceps muscles during the periods of NMES stimulation (active co-contraction) to enhance the strengthening effect and improve tolerance of NMES. Participants were positioned with their legs on a horizontal surface, and the knee supported on a rolled towel. They were asked to perform an isometric contraction of the quadriceps for the duration of the stimulus, by tightening the thigh muscle and pushing the knee down on towel without lifting the foot. Where appropriate, participants could progress the co-contraction exercise if their strength improved. For this second stage they were instructed to raise their leg off the surface and completely extend the knee against gravity.
The study physiotherapist called or met with each participant at the mid-point (3 weeks) of the study to give additional instruction if needed. Each patient had a maximum of 6 weeks (42 days) of NMES and the total (days) and % maximum possible adherence were calculated using the logs of daily NMES use completed by each patient. Study completion was achieved if patients completed the assessment at the end of the intervention period. Patient adherence was measured using an intervention diary in which participants were asked to log their use of the NMES machine daily, and document any variance from the prescribed intervention. The percentage of maximum possible adherence was calculated using the total number of days during the intervention period when the patient could have used the NMES machine. Thus, if the patient was hospitalized for 7 days during the study, the % maximum possible adherence was calculated as a proportion of 35 days not 42.
Feasibility was assessed by measuring the proportion of patients who completed the 6-week intervention, and by the overall level of adherence achieved over the intervention period. Acceptability of NMES was evaluated at the end of the 6 weeks by a brief structured questionnaire developed for this study which was completed by each patient. The questionnaire used a 5-point Likert scale to rate their answers from 1 = "strongly disagree", 2 = "disagree", 3 = "neutral", 4 = "agree", 5 = "strongly agree".
Physical performance measures were performed at baseline (PS, 6 MWT, STS) and at the end of the study. To determine the effects of adherence with NMES on physical function parameters, results were compared in patients with <40% (poor) vs >40% NMES adherence.
The study was approved by the Jewish General Hospital Research Ethics Committee and all participants provided written informed consent.
Comparison between participants who did and did not complete the study was performed using unpaired t-test and Fisher's exact test for continuous and categorical variables respectively. Assessment of change from before and after NMES intervention was performed using paired t-tests or Fisher's exact test for PS category count data. To assess factors potentially relevant to adherence and change in physical performance tests, mean differences were compared using t-tests and differences in counts within categories were assessed using Fisher's exact test. All analyses were performed using R .
111 new patients were seen in the CNR-JGH clinic between June 2010 and July 2011. Of these 52 (47%) were potentially eligible for the study (poor performance status and/or inability to attend hospital-based exercise training). After further screening, 37 patients were approached and of these 18 (49%) patients were recruited. The reasons that 19 patients were not consented for the study ranged from medical deterioration (3) or improvement (1), preference for standard exercise (4), feeling that the study was not of interest or too burdensome (6), and follow-up and communication difficulties with study coordinator (5). Of the 18 patients who gave signed consent, three withdrew from the study and did not proceed to baseline assessment (Figure 1). Reasons for early withdrawals included: rapid medical deterioration and death (n = 1), started exercising regularly at a local gym (n = 1), withdrawn due to language and communication difficulties which became evident only after consent was obtained (n = 1). The remaining 15 patients underwent baseline function testing and their demographic and disease characteristics are shown in Table 1. Two patients with good PS (PS = 1) were also included in the study as they were not exercising regularly and could not attend the usual hospital-based supervised training sessions. The majority of patients (73%) had metastatic (stage IV) disease. The most common tumour types were lung or gastrointestinal cancers, but five patients had other types of tumours including breast (n = 1), ovarian (n = 1), endometrial (n = 1) and haematological (n = 1) malignancy. One additional patient was being treated with cyclical intravenous chemotherapy for systemic amyloidosis without overt evidence of underlying malignancy. Overall 67% of the patients were undergoing active treatment with chemotherapy and 40% were taking, or had completed within the preceding 14 days, an extended (≥3 weeks' duration) course of corticosteroids (Table 1). Results of functional testing at baseline are shown in Table 2. As a group, the patients in this study had impaired exercise capacity with mean 6 MWT of 257 m (50.2% predicted) and mean STS time of 8.0 s, which is 2.6 standard deviations above the mean expected in (i.e. slower than) healthy individuals of similar age (Table 2).
Breakdown of reasons for early and late withdrawals from the NMES study.
Notes: P indicates result of significance testing (unpaired t-test for means or Fisher's exact test for count data) comparing patients who did, or did not, complete the study.
Notes: Performance status (PS), six-minute walk distance (6 MWT) in metres (m) and expressed as % predicted (from ), Sit-to-stand (STS) test expressed as seconds (s) and as a standard score (S-score) value calculated using age range-specific mean and standard deviations for healthy controls (from ): positive scores indicates STS S-scores above the mean. Pa: #Fisher's exact (for counts) or unpaired t-test (for means) comparing baseline results for patients withdrawn and patients who completed study. Pb : #Fisher's exact (for counts) or paired t-test (for means) comparing baseline and final test results for patients who completed the study.
Completion of the study was achieved by 10 (66.6%) of the 15 patients. All 15 had baseline assessments, used the NMES for the 6-week intervention period, and completed the final assessments. Four of the five late withdrawals were not due to the NMES intervention, namely: death (n = 1) and deterioration in medical status (n = 3). Only one patient withdrew because they found they could not tolerate the local discomfort due to repeated NMES treatments (Figure 1). For those completing the study the machine was used for mean(SD) 20.1(13.0) days during the 42-day study period. When the adherence was adjusted to account for periods when NMES had to be stopped during hospital admissions, this showed that patients used their machines over half the available time (mean(SD) 54.2(32.8)%). On closer examination there were in fact three groups: three poorly adherent patients (mean(SD) use 14.3(6.3)%), three moderately adherent patients (mean(SD) use 49.4(1.1)%) and four highly adherent patients (mean(SD) use 87.8(8.7)%) (Figure 2). Thus, 7(70%) patients completing the study achieved more than 40% adherence: equivalent to NMES use at least three times a week. In subsequent analysis to explore the potential impact of adherence on physical function two groups were defined: poorly adherent (<40%, n = 3) and adherent (>40%, n = 7) patients.
Histogram of adherence with NMES intervention during study.
Informal feedback during the study was positive about the use of NMES at home. Furthermore, the acceptability of NMES at a group level was captured using the questionnaires at the end of the study. More than 50% of patients felt strongly that 6 weeks' of NMES use was acceptable (Table 3: C). Furthermore, a majority of patients reported that NMES was a useful in helping with activities and symptoms (Table 3: F, G). In addition 50% of patients were interested in using NMES outside of a study (Table 3: H).
Notes: Allowed responses ranged from 1–5 where 5 = "totally agree" (see Methods).
Baseline and final assessment results were compared for Completers (Table 2). Global performance status and STS appeared somewhat better, but these changes did not achieve statistical significance (Fisher's exact test p = 0.15 comparing categories of PS; mean reduction in STS = −1.2s, P = 0.3). Only one patient was unable to perform the 6 MWT at baseline, but they had improved and walked 220m at end of study. However, as a group there was no change in mean 6 MWT distance after the NMES intervention period (mean difference = −21.1m, P = 0.7) (Table 2). Adherence with NMES might be expected to be a major determinant of improvement in physical function, but we were not able to detect any such effect of adherence with the number of patients recruited in this study. Thus, the patients with poor adherence (<40%, n = 3) did not have significantly different changes in STS or 6 MWT compared to the adherent patients (>40%, n = 7) (P = 0.56, 0.71 respectively). It was also noted that those on long term steroids had significantly reduced 6 MWT at beginning of study (mean(SD): recent steroids 166(139)m vs no steroids 394(88)m, P = 0.04). We hypothesized that NMES may have a particularly useful role in promoting improving function in these patients. However despite a trend towards differential improvement in patients on steroids, this did not reach statistical significance (6 MWT mean(SD) change: recent steroids 35(184)m, no steroids −59(161)m, P = 0.4). A test of proportions gave similar suggestive but non-significant results for both change in 6 MWT and PS, e.g. for PS: 3 out of 4 patients who had recently been on an extended course of oral corticosteroids reported improved PS compared with only 1 out of 6 non-steroid-treated patients (Fisher's exact test, P = 0.19).
This is the first report of the use of NMES in patients with advanced cancer and poor performance status or other barriers to usual exercise training. Our results suggest that NMES is feasible and well-tolerated in this group of patients with advanced cancer who are unable to attend hospital-based exercise training. Only one patient (7%) withdrew from the study because they were unable to tolerate the NMES intervention, whereas four patients (27%) withdrew or could not complete the study, because of medical complications or death. Furthermore, qualitative feedback confirmed that home-based NMES is highly acceptable. There was a wide range in adherence with NMES over the 6-week period of intervention, but despite this, 70% of patients used the NMES for at least 40% of the available days. This equates to use at least three times a week, which is the usual frequency for standard exercise training programs. Repeated physical performance testing before and after NMES revealed wide intra-individual variability. However, there was no improvement in objective measurements of exercise function after NMES intervention (Table 2). Furthermore, no dose-effect of NMES was demonstrated, as there were no differences in physical functional outcomes, between adherent (>40% maximum usage) and poorly adherent (<40% maximum NMES usage) patients.
We recognize a number of limitations to interpreting our results, including the small number of analyzable patients (10) in this pilot study. The primary study objective was to assess feasibility and acceptability of NMES in a variety of cancer patients and for this reason the patients recruited for the study had a range of pathological types and stages of cancer. However, as a result the study participants also had a widely varying initial functional status and exercise performance, making it more difficult to reliably detect functional changes attributable to NMES. We did not include an untreated control group to assess the likely spontaneous changes in outcome measures over the same time period. In debilitated advanced cancer patients, progressive physical deterioration may be anticipated. Thus a reasonable minimal expectation of successful NMES, and other exercise interventions, would be to inhibit this deterioration, rather than achieve an improvement from baseline. Without an untreated comparison group we are unable to say whether there was any indication of this beneficial effect of NMES in the current study. Due to limited personnel resources, the same physiotherapist who instructed the patient in the use of NMES also performed the outcomes assessments. This raises the possibility of patient response bias, particularly for reported global performance status and responses to questionnaire items.
Maddocks et al.  reported only 15/30 lung cancer patients receiving palliative chemotherapy completed approximately 10 week NMES intervention. In contrast to the present study, they concluded that NMES was not an acceptable treatment based on a pre-defined 80% group adherence threshold . However it is notable that in line with our results only 3(11%) of their patients withdrew because of NMES discomfort suggesting that the intervention, per se, is tolerable for the majority. Furthermore, without any correction for periods when patients were hospitalized etc., 50% of patients in the study by Maddocks et al. achieved the required three times a week treatment frequency, and another 3 patients fell below this threshold because of only one missed session. We would concur with the authors of that study who acknowledged that their conclusion, that NMES is "unacceptable", may have been based on unrealistically stringent criteria .
Published studies of use of NMES describe a range of different electrical stimulation protocols  and there is no clear consensus as to the optimal stimulation frequency, electrode placement sites and duty-cycle etc. The original intention in this study was to use dual stimulation of quadriceps and gluteus muscles. However, it became clear that there were both practical and patient acceptability difficulties in repeatedly and consistently placing the gluteus muscle electrodes, especially in very sedentary patients or those requiring help from caregivers to do so. As a result a simplified protocol was used with electrical stimulation of quadriceps only, combined with active voluntary co-contraction of the stimulated limb muscles, to enhance the contractile stimulus. The use of active co-contraction is novel and proved both practical and acceptable as demonstrated by the feedback received (Table 3). Other informal comments received also suggested the patients appreciated the ability to participate in their exercise training even in this limited way.
Our study was not powered to detect differences in the physical outcome measures and many other confounding factors, including acute changes in medical status, can influence the results of the physical performance tests. The physical outcomes measures adopted (PS, STS, 6 MWT) have been widely used in studies of cancer patients and are relevant to normal daily functional activities . However, direct measurements of muscle strength or cross-sectional area, have been used by other authors [11, 14, 17], and these approaches may be more sensitive to detect modest short-term improvements in muscle induced by NMES. Analysis of pooled data from several different studies of NMES in chronic medical conditions suggests NMES use leads to a mean improvement in 6 MWT of 40 m . However we calculated that 127 patients would be needed to detect a difference of 40 m in 6 MWT (effect size 0.25 SD) with 80% power in any future study, without modifying the entry criteria. This is directly related to the wide variance in initial 6 MWT results. Thus stratifying analysis or selecting patients with a pre-defined baseline performance (e.g. by 6 MWT distance) would make it easier to detect subsequent changes after NMES intervention.
High drop-rate rates and the continuing uncertainty about which patients are most likely to respond to NMES physiologically, present significant challenges to successful completion of studies of NMES in cancer patients. It is noteworthy that many studies in COPD and CHF conclude that use of NMES may be best targeted to the most debilitated patients with very poor function . However cancer patients who have both advanced disease and impaired functional status (e.g. 6 MWT <350 m at baseline ) have very poor prognosis, and even short-term studies in these patients are likely to suffer substantial dropouts [3, 8] due to medical deterioration and death. In this pilot study we were not able to confidently identify any subgroups of patients who have greater potential to complete the NMES intervention. Thus patients who did not complete the intervention had a trend towards lower mean baseline 6 MWT distance (166 m Withdrawn vs 303 m Completed, P = 0.11) (Table 2). However, neither this nor any other demographic or physical function results at baseline were significantly different between those that completed and those who were withdrawn from the study (Tables 1, 2).
One group of patients who may be more likely to benefit from NMES are those that have taken a recent prolonged course of corticosteroids, given that corticosteroids are both widely used in cancer therapy and can cause myopathy . Consistent with this notion, the data from this study did confirm that those patients recently treated with steroids had poorer function at baseline (6 MWT mean(SD): recent steroids 166(139)m vs no steroids 394(88)m, P = 0.04). However there was only a non-significant trend towards a differential improvement in 6 MWT in patients treated with extended courses of steroids. Nevertheless, further studies of NMES may be warranted to establish if early use of NMES can be of particular benefit in cancer patients treated with prolonged courses of steroids. Similarly, it is conceivable that other subgroups of cancer patients should be considered for more focused studies, including the more elderly patients with comorbidities  and those being treated with antitumour agents, such as Sorafenib, which promote muscle loss .
The results of the current pilot study suggest that NMES is both feasible and acceptable in a mixed group of patients with cancer, most of whom had poor performance status. This study does not demonstrate that NMES leads to improved physical functioning in cancer patients with poor performance status despite the success of NMES in other chronic diseases and clinical settings. One reason for the difficulty in detecting functional benefits of NMES in cancer patients may be their marked heterogeneity in terms of medical status and physical functioning. As a result, though it is likely that NMES has a role in achieving or maintaining optimal functional ability in selected patients with cancer, this still remains to be confirmed by future prospective studies. Such studies should be designed to both identify the best candidates for NMES interventions and to confirm the optimal method of delivery of this type of therapeutic exercise.
TS and TW are physiotherapists who worked in the CNR-JGH team during the study. BV worked as study coordinator with the CNR-JGH team during the study. RTJ is an MD and Director of the CNR-JGH team.
Tamara Windholz, Tara Swanson contributed equally to this work.
An erratum to this article is available at http://dx.doi.org/10.1186/1472-684X-13-33.
The authors gratefully acknowledge the support of the other members of the CNR-JGH team. They also thank Lillian and Stephen Vineberg, the organizers and participants of the Angel Ball and the Annual Lila Sigal Hockey Marathon for funding to support the CNR-JGH service.
RTJ has received payments as an advisory board member for NEOMED and lecturer fees from Abbott Laboratories. The authors confirm that individuals or groups who have provided funding for the CNR-JGH activities have not been involved in any aspect of the study design, execution or analysis.
RTJ and TS conceived and designed the study, wrote the protocol and obtained initial ethics approval. TW finalized the study protocol, performed the patient testing and supervised the NMES interventions. BV recruited patients and coordinated the study including completion of study database. RTJ analysed the study results. All authors contributed to the writing of the manuscript. All authors read and approved the final manuscript.


Function Library is a reusable component which can be used multiple times across same or different Test Cases. These functions are user-actions which can be repetitive. You can reference input and output parameters corresponding to the function. This OpKey module is flexible, scalable and robust in nature i.e. function(s) made in this module can be further used among different Test Cases in the form of test steps.
For example: For a shopping portal web-application, four function libraries can be created. One Function library can be for logging into the portal, other for searching the product, third for buying a product and the last one for logging out of the portal. These function libraries can be used in different test cases individually.
After successfully login into OpKey Web, select the appropriate Project in which you want to create a Function Library File.
Click "End Tour" to proceed with the process of creating a Function Library file.
How to create a Function Library File?
After clicking on "End Tour" , you may "Click to Create New Artifact".Select Function Library.
The "Function Library" text will appear highlighted.
The fields marked with * are mandatory. Enter the Name of the Function Library. You can also enter the Description. Click OK.
Go to Project Workspace > Select the root Folder > Click Create New file icon > Select Function Library.
A Function Library file will be created in the root Folder of the project Workspace.
You may rename the Function Library accordingly.
Right click on root folder > select Create New > select 'Function Library'.
There are two way of creating Function Library : By adding test steps and by recording.
Let's first discuss about creating Function Library by adding test steps in the next article.
Open in New Tab feature enables you to view added artifacts (FL, SR method, Mapped Objects, & Mapped DR) in a Function Library.
You can click on the Open in New Tab option of the added Function Library to open it into a new tab.
You can right click on added Service Repository Method and select Open in New Tab option.
You can view mapped object with a Function Library Test step in detail. Right click on mapped object and then click Open in New Tab.


We're a week and a half away from Apple's iPhone gala, which means we're in the absolute thick of Apple rumor season. And while you may have tired by now of hearing about—and seeing—that stretched-out unibody handset, this latest curveball from Vietnam should have your full attention.
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Michael troth serena software
We are committed to creating an inclusive environment for all employees. The company is listed on the london stock exchange and is a constituent of the ftse 250 index. This begins prepilot and ignores the majority of canon. Michael brings to e2open more than 20 years of sales, marketing and leadership experience in supply chain management and enterprise software. She sings and plays the songs from different countries and she performs at various venues in switzerland and in different countries. The second best result is serena d mosteller age 50s in bowie, md.
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Below are my thoughts on the people who could potentially be the next serena williams or michael jordan of the tech industry. It seems a very personal and instinctive way of working, but she is also very good at capturing an insightful likeness in her portraiture, which makes for a powerful combination. Top kodi archive and support file community software vintage software apk msdos cdrom software cdrom software library. View serena tsois profile on linkedin, the worlds largest professional community. The grounds of the venue are predominately grass, so ladies bear that in mind when choosing your choice of shoes.
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This is what the author has to say of him: "In one of Scheherazade's tales I read of the Fisherman who found a copper vessel in his net. In the vessel was a mighty Genie — a magician who had been imprisoned in the bottle for nearly two thousand years. The Genie had sworn to make the one who freed him rich, powerful and happy.
At 7:32 a.m. a merry sun-spot slipped through a hole in the curtain and settled on the nose of Volka Kostylkov, a 6th-grade pupil. Volka sneezed and woke up.
Then they had all argued as to the best place to put the things so as to have them handy when the truck arrived in the morning. Then they had their tea on an uncovered table — as on a march. Then they decided their heads would be clearer after a good night's sleep and they all went to bed.


Hi Thanks for your video love love, how does this decal foil hold up in the wash….?
Lorrie this is such a wonderful project. Am wondering how this holds up to washing.?
Beautiful. But how will the foil stand up to washing, I wonder? I'd love to know about a follow-up. Thanks, Lorrie.


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ACCEPTED

#### According to
Index Fungorum

#### Published in
Mycotaxon 9(2): 488 (1979)

#### Original name
Puccinia pilearum Durrieu

### Remarks
null


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Kourtney Kardashian and Travis Barker star on the Oscars Red Carpet
Kourtney Kardashian and Travis Barker are one of the hottest couples of the moment. During the Oscars Awards 2022 gala, they became the stars of the red carpet and gave us quite a few very romantic moments in front of the cameras.
For the first time, a member of the Kardashian family made her debut on the red carpet of these distinguished awards in film and music. Kourtney Kardashian not only gave style lessons as usual in her public appearances but also attended hand in hand with her fiancé Travis Baker. More in love than ever the couple made their debut in front of the cameras at the Dolby Theatre in Los Angeles.
They went with a lot of class and elegance thanks to their black outfits. Kourtney chose a classic dress tight to the body to define the curves and with an opening in the leg inspired by the mythical Hollywood. The dress is an exclusive vintage design by Mugler. Kris Jenner's eldest daughter, Kris Jenner, joined the wet hair trend with her hair to one side which completed the perfect look for the first time at the Oscar Awards. Her fiancé Travis combined the same black tone with a suit to make the perfect match.
During the red carpet, the businesswoman and the singer expressed all the love they feel for each other. Travis couldn't help but show his affection and while he was very attentive to her, he gave her several very hot kisses. At all times, both were holding hands and when they weren't kissing they were throwing a smiling wave to the cameras. When they passed by the cameras, Travis was heard dedicating very nice words very nice and from the emotion they started dancing.
Kourtney Kardashian and Travis Barker were one of the stars of the night and were undoubtedly the stars of this red carpet. The couple is one step away from the altar and although her sisters Kim and Khloé already lived the excitement of getting to the altar, for Kourtney this is totally new, so she is very excited about the preparations.
Víctor Andrés
Oscars Awards
Beyoncé shines in Valentino dress at Oscars 2022
Kim Kardashian and Julia Fox meet at the same party after the Oscars


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Death in Manchester
By Brian H. Gill - May 24, 2017
(From European Press Agency , via BBC News, used w/o permission.)
("Thousands attended a vigil in Manchester earlier"
(BBC News)
Manchester is England's second-largest urban center, in terms of population.
At around 10:30 Monday night, something like 21,000 folks — pre-teens, teenagers, adults — were leaving a music concert at the Manchester Arena. Someone with a bomb set it off in or near the arena's foyer.
He's dead. So are more than 20 other folks.
Except for the chap who killed them, the dead had been enjoying an Ariana Grande concert. The youngest victims I've read about were eight years old.
Quite a few others are injured. Some are missing.
I am not happy about this, putting it mildly....
More at A Catholic Citizen in America.
being Catholic citizenship death emotions immigrants love tolerance


We have just made modifications to Hatena Star to allow its use on voice browsers. With this update, we have assigned a tabindex attribute to the Add Star button, Comment button, and the Star so that you can add a Star or open a comment window using the Enter key on your keyboard.
We had received complaints from voice browser users as well as other users who wished to operate our system without using a mouse. With today's update, you can operate basic functions through the keyboard. We hope you find this new feature helpful.
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HomeNEWS & RESULTSMMA NEWSLyoto Machida comments on UFC on Fox 19 removal over USADA violation: "I was caught by surprise by this news"
Lyoto Machida comments on UFC on Fox 19 removal over USADA violation: "I was caught by surprise by this news"
Lyoto Machida has made a statement following his removal from Saturday's UFC on Fox 19 event, and revealed that the substance he disclosed taking was 7-keto-DHEA.
Available in over the counter supplements, the substance was nevertheless on the WADA banned list used by USADA, and a quick search of the product would have revealed that. For his part, Machida apologized and said he had not been aware the substance was placed on the banned list.
"I'm here to tell you that I was caught by surprise by this news," Machida wrote on Facebook. "It has been very difficult for me. I've trained a lot for this fight, I've dedicated a lot with all my team mates. I want to tell you that I really didn't know about this substance, so I listed it on my declaration form amongst everything else I was taking, and this substance was recently banned in 2016, so I take the blame for not knowing that, and I'd like to say I'm really sorry and apologize to my fans, team mates, and my family… I always try to play by the book, but unfortunately this happened."
Dan Henderson, Machida's scheduled opponent for Saturday's card in Tampa, Fla., was none too pleased with the news on Wednesday, tweeting out the following:
P.O.S. -No respect https://t.co/03O5oM7sM9
— Dan Henderson (@danhendo) April 13, 2016
Penick's Analysis: This particular substance was not just added in 2016, as athletes have been suspended for it under the WADA code in past years, so this is a complete failure on Machida's part to check his supplements. That part is at least believable, because he himself disclosed what he was taking not realizing it wasn't allowed, and if he'd been trying to skirt a test and hope for a clean result he likely would have tried to hide it. Let this be a lesson to all fighters taking any supplements: just because it's available over the counter doesn't mean it can be used in sport. Check the WADA and USADA sites for the banned list, hit ctrl+f and search for anything in your substances. If it's on there, don't take it. Simple.
[Photo (c) Joe Camporeale via USA Today Sports]
usada
D. FOX: Post-fight reactions to UFC 198 "Werdum vs. Miocic" from Brazil
ROUNDTABLE: What does it mean for UFC's featherweight division if champ Conor McGregor doesn't drop back down?
TUF 22 REPORT 11/4: Penick's thoughts on episode seven of "Team McGregor vs. Team Faber" season


text:
Q: Testing async method using React testing library I have button in component:
<button
    type="button"
    title="Logout"
    data-testid="logout"
    onClick={logout}
>

and method logout:
const logout = async () => {
    try {
        await authLogout()
    } catch (error) {
        console.error(error)
    } finally {
        props.history.push('/login')
    }
}

Now I trying testing logout method by click on button:
describe('UserMenuComponent', () => {
  it('go to login page after click on logout', async () => {
    const history = createMemoryHistory()

    const { getByTestId } = render(
      <Router history={history}>
        <UserMenuComponent />,
      </Router>,
      {
        initialState: { reducersAuth: initialState },
      },
    )

    fireEvent.click(getByTestId('logout'))
    expect(history.location.pathname).toBe('/login')
  })
})

Inside method logout in finally block I have props.history.push('/login') and I check this in my test: expect(history.location.pathname).toBe('/login') but test return error:
expect(received).toBe(expected) // Object.is equality

Expected: "/login"
Received: "/"

A: You should use useHistory() hook to get history object inside your SFC.
Besides, since the logout function is an async function, you should use waitFor method to wait for your expectations to pass.
E.g.
UserMenuComponent.tsx:
import React from 'react';
import { useHistory } from 'react-router-dom';

async function authLogout() {}

export function UserMenuComponent() {
  const history = useHistory();
  const logout = async () => {
    try {
      await authLogout();
    } catch (error) {
      console.error(error);
    } finally {
      history.push('/login');
    }
  };

  return <button type="button" title="Logout" data-testid="logout" onClick={logout}></button>;
}

UserMenuComponent.test.tsx:
import { fireEvent, render, waitFor } from '@testing-library/react';
import React from 'react';
import { Router } from 'react-router-dom';
import { createMemoryHistory } from 'history';
import { UserMenuComponent } from './UserMenuComponent';

describe('UserMenuComponent', () => {
  it('go to login page after click on logout', async () => {
    const history = createMemoryHistory();
    const pushSpy = jest.spyOn(history, 'push');

    const { getByTestId } = render(
      <Router history={history}>
        <UserMenuComponent />,
      </Router>
    );

    fireEvent.click(getByTestId('logout'));
    await waitFor(() => {
      expect(pushSpy).toBeCalledWith('/login');
      expect(history.location.pathname).toBe('/login');
    });
  });
});

test result:
 PASS  examples/66571376/UserMenuComponent.test.tsx
  UserMenuComponent
    ✓ go to login page after click on logout (82 ms)

-----------------------|---------|----------|---------|---------|-------------------
File                   | % Stmts | % Branch | % Funcs | % Lines | Uncovered Line #s
-----------------------|---------|----------|---------|---------|-------------------
All files              |   91.67 |      100 |     100 |   90.91 |
 UserMenuComponent.tsx |   91.67 |      100 |     100 |   90.91 | 12
-----------------------|---------|----------|---------|---------|-------------------
Test Suites: 1 passed, 1 total
Tests:       1 passed, 1 total
Snapshots:   0 total
Time:        3.881 s, estimated 4 s

A: You can use waitFor to wait for your expectation to pass.
await waitFor(() => expect(history.location.pathname).toBe('/login'))

redpajama_set_name: RedPajamaStackExchange


Every other Tuesday, professionals from across the Boulder and Denver tech communities pour into Atlas Purveyors on Pearl Street beginning around 7:30AM. By 7:45AM, you're lucky if you find a place to sit — it's usually standing-room-only by this time.
At 8AM sharp, Boulder Open Coffee Club begins. News is discussed, business partnerships are born, jobs are announced, and those seeking jobs make their presence known.
Boulder Open Coffee Club was founded as a bi-weekly gathering point for Boulder's tech community. Over time, the group has grown into more than just the software developers and their fellow tech enthusiasts, however.
Throughout Boulder, there's no shortage of places to catch a live music show. From local coffee ships after sundown to larger venues, The Boulder Theater offers some of the area's richest performing history in all of Boulder County.
The Boulder Theater opened in 1906, originally as an opera house. Today, residents across the Front Range can enjoy a wide variety of performances inside its beautiful walls.
Artists like Martin Sexton, The Punch Brothers, and the Avett Brothers have all graced its modern day stage. It's also a popular venue for community events like the always sold-out Ignite Boulder, an evening event filled with five-minute presentations from members of the community.
Living in Boulder, you'll want to keep an eye on all of the live music events that tour through town. For that, The Fox Theatre is a must-add to your list.
Situated over by the University of Colorado – Boulder campus on The Hill, The Fox Theatre hosts a wide range of performances throughout the year. Most shows are general admission (read: no seating, standing room only), so be sure to wear your comfortable shoes as you'll be on your feet for awhile!
Since The Fox is located so close to the CU campus, it frequently hosts all-ages shows to accommodate the student population in Boulder. If you're ever curious about whether a show you're interested in is all ages, just pop over to the home page and the current upcoming show along with the future calendar will be posted, including whether the show is 21+ or all ages.
Where do you go when you need inspiration? Events in Boulder range from outdoor sports and live music to others that will have your mind churning with new ideas.
TEDxBoulder began in 2012 and is now the world's largest independently organized TED event. It's even bigger attendance-wise that the annual TED conference itself. If you're looking for an evening to spark inspiration and open your mind to new ideas, you could do worse (can you say Honey Boo Boo worse?) than grabbing a ticket to the annual TEDxBoulder.


The Vashikaran Totka mentioned above is very simple and uncomplicated to practice, but it would be prudent to add that I have not tried or tested this Mrityu Vashikaran Totka myself nor have I heard about anyone gaining success in averting death by controlling the mystical powers, which trigger it off in any living being, including humans.
There are some authentic reports of Sadhus and Yogis living in the most remote regions of the Himalayan Range, who are said to have existed for centuries. It is most likely that such Sadhus would have gained Siddhi through some very difficult and secret Tantrik Sadhanas and Mantra Experiments.
1] It can be practiced on any day at any time because the Ullu Tantra does not recommend any specific or auspicious dates or timings.
2] An owl has to be captured and its heart has to be separated from the body and mixed with Gorochana to prepare a very fine paste.
3] The Ullu Tantra says that if the practitioner applies this paste like an eye-liner[Kajal] in his eyes, even death will become Vishibhut [come under a spell of attraction] with the practitioner and this will increase the life span of the practitioner.
There is another mention in the Tantra about the same Vashikaran Totka, using the same Vashikaran paste, which has been described below.
This mention says that applying the same paste as an eye-liner in the eyes will make any person whom the practitioner makes eye-contact with instantly come under a strong Vashikaran Spell and become submissive and come under the total control of the practitioner. Such a person, be it a man or woman will do whatsoever the practitioner desires.
Note- The Ullu Tantra has not prescribed or recommended any Infusion Mantra nor any kind of Vashikaran Puja-Vidhi for performing the Vashikaran Experiments described by me in this post.
This is an Aghori and Tamsik Vashikaran Sadhana as it involves killing an owl and making the use of its heart.
Hello Sir,I want some suggestion from you but don't know where to post. So I am just posting here. In my kundli there is Brahmaan/Guru Shraap as Brihaspati is in neech(makar) rasi and Rahu in Dhanu rasi in Lagan.Please tell some mantra or any remedy to get rid of this Brahmaan dosha.


text:
Find Is Calendly Worth It – 10 Million Users
Today we are going to be discussing Is Calendly Worth It…I have actually utilized Calendly in a handful of various methods. My number of meetings increased when I was using Calendly.
Today comes news from a startup that has been a part of that pattern: Calendly, a popular cloud-based service that individuals use to set up and verify meeting times with others, has closed an investment of $350 million from OpenView Venture Partners and Iconiq.
The financing round includes both primary and secondary cash (a little more of the latter than the former, from what I comprehend) and values the Atlanta-based startup at over $3 billion.
Okay for a company that before now had raised just $550,000, consisting of the life savings of the creator and CEO, Tope Awotona, to initially get off the ground.
Calendly is a freemium software-as-a-service, built around what is basically a very basic piece of functionality.
It's a platform that provides a quick method to manage open spaces in your calendar for people to book visits with you in those spaces, which then likewise books out the time in calendars like Google's or Microsoft Outlook– with a growing number of tools to boost that experience, including the ability to spend for a service in case your consultation is not a business conference but, state, a yoga class. Prices varieties from totally free (one calendar/one user/one occasion) to premium ($ 8/month) and professional ($ 12/month) for more calendars, occasions, functions and combinations, with larger packages for business likewise offered.
Its growth, on the other hand, has to date been based mostly around an extremely natural technique: Calendly invites become links to Calendly itself, so individuals who use it and like it can (and do) start to utilize it, too.
The vast array of its use cases, and the virality of that development method, have actually been winners. Calendly is already lucrative, and it has actually been for many years. And more recently, it has actually seen an increase, particularly in the last twelve months, as new Calendly users have emerged, as a result of how we are living.
We may not be doing more conventional "organization conferences" weekly, but the variety of conferences we now require to set up, has actually gone up.
All of the unscripted and serendipitous encounters we used to have around a workplace, or a community coffee bar, or the park? Those are now scheduled. Educators and students meeting for a remote lesson? Those likewise need invitations for online meetings.
And so do sessions with therapists, virtual dinner celebrations, and even (where they can still take place) in-person meetings, which are typically now occurring with more timed precision and more record-keeping, to keep social distancing and potential contact tracing in much better order.
Currently, some 10 countless us are utilizing Calendly for all of this on a regular monthly basis, with that number growing 1,180% in 2015. The army of company users from business like Twilio, Zoom, and UCSF has been signed up with by teachers, specialists, business owners, and freelancers, the company says.
The company in 2015 made about $70 million every year in subscription revenues from its SaaS-based business design and seems confident that its aggregated incomes will not long from now get to $1 billion.
So while the secondary financing is going towards offering liquidity to existing investors and early workers, Awotona said the plan will be to utilize the main capital to buy the business's business.
That will include building out its platform with more tools and combinations– it started with and still has a considerable R&D operation in Kiev, Ukraine– expanding its operations with more talent (it presently has around 200 workers and strategies to double headcount), more business advancement and more. Is Calendly Worth It
2 significant proceed that front are also being revealed with the funding: Jeff Diana is beginning as primary people officer with a mission to double the company's employee base. And Patrick Moran– previously of Quip and New Antique– is joing as Calendly's very first chief revenue officer. Significantly, both are based in San Francisco– not Atlanta.
That focus for building in San Francisco is already a huge modification for Calendly. The startup, which is going on eight years old, has actually been somewhat off the radar for several years.
That is in part due to the reality that it raised extremely little money already (just $550,000 from a handful of investors that include OpenView, Atlanta Ventures, IncWell and Greenspring Associates).
It's likewise based in Atlanta, an increasingly significant city for technology startups and other business but usually short on being credited for its heft in that department (SalesLoft, Amex-acquired Kabbage, OneTrust, Bakkt, and many others are based there, with others like Mailchimp also not too far).
And perhaps most of all, proactively courting promotion did not seem part of Calendly's development playbook.
Calendly may have closed this huge round quietly and continued to get on with service, were it not for a short Tweet last autumn that indicated the company raising cash and forming up to be a peaceful giant.
" The business's capital effectiveness and what @TopeAwotona has actually developed are worthy of way more credit than they get," it checked out. "Maybe this will start to alter that acknowledgment."
Does Calendly have a free option? Is Calendly Worth It
After that short note on Twitter– flagged on TechCrunch's internal message board– I made a guess at Awotona's email, sent out a note presenting myself, and waited to see if I would get a reply.
I eventually did get a response, in the form of a brief note consenting to chat, with a Calendly link (naturally) to choose a time.
( Thanks, unnamed TC author, for never discussing Calendly when Tope initially pitched you years ago: you might have whet his hunger to respond to me.). Is Calendly Worth It
Find Calendly Reminder Text – 10 Million Users
Find Calendly Sync Multiple Calendars – 10 Million Users
Today we are going to be discussing Is Calendly Worth It…I have actually utilized Calendly in a handful of different ways. The most common use case for myself is through my emailing and prospecting tool. I connect to a lot of people through e-mail. Many individuals don't wish to make the effort to respond, so having a link in the email makes the scheduling procedure much easier. When I was making use of Calendly, my number of conferences increased.
Today comes news from a start-up that has been a part of that pattern: Calendly, a popular cloud-based service that individuals use to establish and verify meeting times with others, has closed an investment of $350 million from OpenView Venture Partners and Iconiq.
The financing round consists of both primary and secondary money (a little more of the latter than the former, from what I understand) and values the Atlanta-based startup at over $3 billion.
Not bad for a business that before now had actually raised simply $550,000, consisting of the life savings of the creator and CEO, Tope Awotona, to initially get off the ground.
Calendly is a freemium software-as-a-service, constructed around what is basically an extremely basic piece of performance.
It's a platform that provides a quick way to manage open spaces in your calendar for individuals to book consultations with you in those spaces, which then likewise books out the time in calendars like Google's or Microsoft Outlook– with a growing number of tools to improve that experience, consisting of the ability to spend for a service in case your appointment is not a service meeting but, state, a yoga class. Prices ranges from free (one calendar/one user/one occasion) to premium ($ 8/month) and professional ($ 12/month) for more calendars, combinations, features and events, with bigger packages for business also available.
Its development, on the other hand, has to date been based mostly around a very natural technique: Calendly welcomes ended up being links to Calendly itself, so people who use it and like it can (and do) start to utilize it, too.
The wide variety of its usage cases, and the virality of that growth method, have been winners. Calendly is currently profitable, and it has been for many years. And more recently, it has actually seen an increase, specifically in the last twelve months, as new Calendly users have emerged, as a result of how we are living.
We may not be doing more conventional "business meetings" each week, but the number of meetings we now require to establish, has gone up.
All of the serendipitous and unscripted encounters we utilized to have around an office, or a community cafe, or the park? Those are now arranged. Educators and students fulfilling for a remote lesson? Those also require invitations for online meetings.
Therefore do sessions with therapists, virtual supper celebrations, and even (where they can still take place) in-person meetings, which are typically now occurring with more timed precision and more record-keeping, to keep social distancing and potential contact tracing in much better order.
Currently, some 10 million of us are using Calendly for all of this on a regular monthly basis, with that number growing 1,180% last year. The army of service users from companies like Twilio, Zoom, and UCSF has been signed up with by teachers, professionals, business owners, and freelancers, the company says.
The business last year made about $70 million every year in membership revenues from its SaaS-based organization design and seems confident that its aggregated profits will not long from now get to $1 billion.
While the secondary funding is going towards offering liquidity to existing investors and early staff members, Awotona stated the strategy will be to use the main capital to invest in the company's company.
That will include building out its platform with more integrations and tools– it started with and still has a substantial R&D operation in Kiev, Ukraine– expanding its operations with more skill (it presently has around 200 employees and plans to double headcount), further business advancement and more. Is Calendly Worth It
Two notable proceed that front are likewise being announced with the funding: Jeff Diana is coming on as chief individuals officer with an objective to double the business's worker base. And Patrick Moran– previously of Quip and New Relic– is joing as Calendly's very first chief earnings officer. Notably, both are based in San Francisco– not Atlanta.
That focus for structure in San Francisco is already a big change for Calendly. The startup, which is going on 8 years old, has been somewhat off the radar for several years.
That is in part due to the truth that it raised very little cash already (just $550,000 from a handful of investors that include OpenView, Atlanta Ventures, IncWell and Greenspring Associates).
It's likewise based in Atlanta, a significantly notable city for innovation start-ups and other business however usually short on being credited for its heft because department (SalesLoft, Amex-acquired Kabbage, OneTrust, Bakkt, and many others are based there, with others like Mailchimp also not too far away).
And possibly most of all, proactively courting promotion did not appear to be part of Calendly's growth playbook.
In fact, Calendly might have closed this huge round quietly and continued to proceed with organization, were it not for a short Tweet last fall that signaled the company raising money and shaping up to be a quiet giant.
" The company's capital performance and what @TopeAwotona has built deserve method more credit than they get," it checked out. "Possibly this will start to alter that acknowledgment."
After that brief note on Twitter– flagged on TechCrunch's internal message board– I made a guess at Awotona's e-mail, sent out a note presenting myself, and waited to see if I would get a reply.
I ultimately did get an action, in the form of a short note agreeing to chat, with a Calendly link (naturally) to select a time.
( Thanks, unnamed TC writer, for never writing about Calendly when Tope initially pitched you years ago: you might have whet his cravings to respond to me.). Is Calendly Worth It
Find Is Calendly Built In To Iphone – 10 Million Users
Find Calendly Schedule Appointments – 10 Million Users


text:
Home » Archive » Shared News » Back in Charge Puts Longtime Friends in the Winner's Circle
Back in Charge Puts Longtime Friends in the Winner's Circle
Sunday, February 9, 2020 at 4:16 pm | Back to: Shared News, Top News
Previous Story | Next Story
In the winner's circle with Back in Charge | Coglianese
By Jessica Martini
When longtime friends and business partners Greg Back and Al LaRose sold their Special Logistics trucking company three years ago, they decided to give racehorse ownership a try. The fledgling racing stable made it to the winner's circle Sunday when longshot Back in Charge (Will Take Charge) scored a dramatic late-running debut victory at Gulfstream Park.
"It was very exciting for us," Back, who watched the race from his Texas home said. "We knew she had it in her, but first time out, you just never know."
LaRose was at Gulfstream for the race, but wasn't quite as optimistic even as he supported his filly at the windows.
"It was awesome," LaRose said of the result. "We are blessed. It was a real awesome experience."
Asked if he expected the victory, LaRose admitted, "I did not. She was a longshot. But I did have $300 across on her, so I won $9,000."
Trainer Ken McPeek purchased Back in Charge on behalf of Back and LaRose's C&H Diamond Racing for $250,000 at the 2018 Fasig-Tipton July Sale. That purchase price was a far cry from the partners' first foray into racing nearly three decades ago with the bargain acquisition of a Texas-bred named Battle of Apollo (Seattle Battle).
"In 1993, I was friends with the track announcer at Sam Houston and I was going there every day and wagering with him," LaRose recalled. "He told me about a horse that was for sale, he was a grandson of Seattle Slew. I bought him sight unseen for $2,500. After I bought him, I called Greg and said, 'I just bought a horse, do you want half?' He said, 'Yeah, I'll take it,' instantly. He won his first race out wire-to-wire and we were hooked. We had him for three years and he paid for himself the whole time."
Racing took a backseat to business for a time, however.
"Greg and I started a business in 1980 with $5,000 a piece and sold it to J.B. Hunt in 2017," LaRose said. "To treat ourselves, we both put up $1 million and bought 10 babies with Kenny. And that was our gift to ourselves."
Back added, "We've been partners and friends since the sixth grade. We decided we wanted to keep our partnership going. And we chose horse racing."
C&H Diamond Racing–named after wives Carol and Hilda–now includes all or part of 15 horses. Also in the group of original yearling purchases is Morning Gold (Morning Line), acquired for $205,000 at the Fasig July sale, who broke her maiden at Saratoga last August. The filly was fifth in the GII Pocahontas S. and sixth in the GII JPMorgan Chase Jessamine S.
"We have Morning Gold, a very fine filly who is hurt right now," Back said. "We have two other 3-year-olds who haven't raced yet. And we just got into a partnership on six or seven yearlings that we bought at the Keeneland September sale."
Back continued, "We are primarily buying yearlings. That's Kenny's expertise and that's one of the reasons that we went with Kenny, his skills at buying horses."
LaRose added, "We just bought six babies with Three Chimneys and a couple other partners at the last Keeneland September sale. We are in it for a while."
Asked about his goals for the racing stable, LaRose said he was trying to keep realistic expectations.
"We've had a horse in Dubai already, we are running with all of the top horses in the world," he said. "So just to not embarrass ourselves and make a good showing, is what I'm looking for. Winning the Derby or something like that would be fantastic, but you know that's one in a million. So we just want to have fun and meet a lot of nice people. People say one in 10 win and we bought 16, so she could be our one in 16."
While the two Texans might be pragmatic businessmen, they've already broken one of their own rules with Back in Charge's name.
"It's kind of a funny story because my partner said we couldn't name them after any of our family," Back said with a laugh. "And when I went to him wanting to name her Back in Charge, he said, 'You can't do that.' And I said, 'I sure can. That's just a verb.'"
LaRose responded, "I liked the name, so I let him get away with it. But you'll be seeing one LaRose-type in the future."
As for what is next for Back in Charge, Back said, "My hope is that she becomes a stakes quality horse, which after that performance, I think she's headed that way. I think she has the conformation and the build, the speed and the pedigree to be one. We're going to have to huddle up with Kenny and see what he wants to do next, but I've got a feeling she will go to some Grade III or something like that, I would think."
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This story was posted in Shared News, Top News and tagged Al LaRose, Back in Charge, Greg Back, Gulfstream Park, Ken McPeek, Special Logistics.
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