text:
The Lake District, Edinburgh & the Outlander Trail
8 day Rail and Trail Journey
Hop on a train from Manchester and join an adventure through the Lake District, Edinburgh, and Outlander's most famous locations.
Ullswater - The second largest lake in the English Lake District is famous for its sublime, tranquil beauty.
Aira Force Waterfall - A lovely stone bridge crosses the fabulously flowing waterfalls.
Lake Windermere - You can choose to wander the shores or put on your sailing hat and go for a cruise.
Edinburgh – Visit the castle, savour the food, and explore one of the most beautiful Medieval cities in the world.
Doune Castle - One of the most filmed castles in Scotland. It stars as Castle Leoch in Outlander, and featured in Monty Python's 'Holy Grail', and the pilot for Game of Thrones.
Loch Ness - Take a chance to go on an optional boat cruise or wander around this alluring and eerie loch.
Culloden - A sad place to visit. It's the location of a tragic Outlander scene and a catastrophic battle between Jacobites and Government troops.
Culross - This town looks like it never left the 16th century. It was also the setting for the fictional Outlander town, Cranesmuir.
Falkland - This quaint town in the Kingdom of Fife boasts a beautiful palace and a serene setting.
Midhope Castle - Jamie's family home, Lallybroch, is as lovely as it looks in the show.
Glencoe - Be moved by the sheer beauty and tragic tales of one of Scotland's most famous landscapes Jamie and Claire travel through
So, you're travelling to Britain.
This means you need to get out and about and discover the sights.
But in all honesty, you'd rather experience every Outlander episode again and again.
Well, we've got the solution for you, because on this tour you can do both.
You first take the quick and comfortable train from Manchester to England's premier beauty spot, the Lake District. Here, your guide takes you rambling around trickling rivers, quaint cottages, and gorgeous mountains.
And after you spend couple of nights in Edinburgh, you head on an adventure to where they filmed Outlander's gory battles, tragic moments, and sultry scenes.
So, forget the couch and combine the Lake District with your favourite TV show on this eight-day tour.
Rail & Trail Journey
Travel from England to Scotland on this trip that combines a one-way train journey with two of our tours. Between the tours, you get free time in Edinburgh. Please see the itinerary for more details.
Check-in closes at 10:45 (tour departs at 11:00) - Manchester Piccadilly Station, Piccadilly Station Approach, Manchester, M60 7RA
*Train times may vary a little. We'll email you your exact departure time before your tour
19:00 - Edinburgh Bus Station Drop Off, Gate J and Gate K, Edinburgh Bus Station, St Andrew Square, Edinburgh, EH1 3DQ
Students and seniors over 60
After booking your tour, we'll contact you about your train journey
Accommodation in Edinburgh sells out fast. But don't worry; when you book your tour, you can ask us to reserve everything for you.
This tour combines two of our trips and a free day in Edinburgh. This means you swap your bus and guide during the journey.
Unfortunately we don't carry anyone under 18 years old on this tour
Transportation by a 16 seat Mercedes mini-coach
A one-way train ticket from Manchester to Penrith
Take as many photographs as you can at 'England's most beautiful lake', Ullswater
Relax in the market town of Keswick
You collect your train ticket at the station and head north from Manchester to the historic Cumbrian market town of Penrith. The town's uniquely coloured castle played a key role in defending the border from its invading Scottish neighbours.
After arriving in Penrith and meeting your Rabbie's Guide, you enter the Lake District National Park and travel along the northern shores of Ullswater. This lake is often described as England's most beautiful lake, and it's here we give you the chance to take a forest walk and see the mighty Aira Force waterfall.
You then travel towards Keswick, stopping outside the town to visit the mysterious Castlerigg standing stones, thought to have been built over 5,000 years ago and a hub of ancient pagan rituals.
You have a short journey into the lively market town of Keswick* where you're dropped off at your accommodation and free to explore the charming town.
* Please note all tours that depart between 18th July and 4th August 2022 stay in Bowness-on-Windermere instead of Keswick.
* All the tours that depart between 20th June and 1st July 2022; 11th July to 15th July 2022; and 11th September to 18th September 2022 stay in Torquay instead of Keswick.
Stare in wonder at the views on an optional boat trip, Lake Windermere
Wander around the cosy village of Hawkshead
After breakfast, you take in views of Ullswater as we head along country roads to its southern shores.
You continue further south and travel over the narrow and winding Kirkstone Pass towards the wonderful Windermere. Here you have the option to take a leisurely cruise on the Lake or eat lunch while enjoying sublime views of the surrounding scenery.
After lunch you travel around the southern tip of Windermere and on towards Coniston Water. Your next stop is the picturesque conservation village of Hawkshead, where the poet William Wordsworth attended Grammar School.
After exploring the cosy village, you take the narrow country lanes north towards Grasmere, which Wordsworth described as "the loveliest spot that man hath found".
There's free time to visit Wordsworth's Dove Cottage, taste the legendary gingerbread, or enjoy the peace and tranquillity of the Wordsworth Daffodil Garden by the River Rothy.
In the late afternoon, you return to Keswick*.
Set your sights on sweeping views from atop the Whinlatter Pass
Learn about the slate mines at the Honister Mountain Pass
We pick you up from your accommodation and head for the Whinlatter Forest Park and over the Whinlatter Pass into the most dramatic landscapes the Lake District has to offer.
You journey along winding lanes, past the shores of Crummock Water and Buttermere, and towards the Honister Mountain Pass.
Stopping amongst the mountains you have the opportunity to enjoy the views of the old slate workings, where a small number of Cumbrians continue to make their living.
After refreshments, you continue through the forests of Borrowdale, passing Derwent Water, where there's free time for lunch and shopping.
Once you've eaten lunch, you begin your return journey, heading towards Penrith and north towards the border. After crossing into Scotland, you take a stop in the town of Biggar, a royal burgh since 1415. From here, it's a leisurely drive through the rolling border hills to Edinburgh.
Wander over cobbled lanes past medieval window panes and under Gothic spires in Scotland's stunning capital city, Edinburgh
Today is a free day to explore Edinburgh.
You can venture deep under the city on ghost tours, hike to the lofty heights of Arthur's Seat, or even just relax in the many beautiful gardens.
Just ensure you relax and prepare for the next part of your adventure.
Get as close as possible to the 16th century in the well-preserved town of Culross. Or as it's known to Outlander fans, Cranesmuir
Visit beautiful Falkland and explore the setting for 1940s Inverness in Outlander
Learn how Highlanders lived at the Newtonmore Highland Folk Museum
Today you join a new bus for the continuation of your tour to the Highlands. You leave Edinburgh and begin following the trail of the best-known film locations featured in the Outlander TV series.
Heading north, your first stop is the charming village of Culross. In Outlander, Culross posed as the fictional village of Cranesmuir and the home of Geillis Duncan and her husband, Arthur. Exploring the town's cobbled streets is like taking a step back in time. Look carefully and you may even find Claire's herb garden behind the impressive Culross Palace.
You continue to the small town of Falkland to relive the first scenes of the show, where Falkland substitutes for 1940's Inverness. See if you can recognize the familiar sights such as Mrs. Baird's Guesthouses (The Covenanter Hotel) and the Bruce Fountain, where Claire's husband Frank sees the ghost of Jamie.
In the early afternoon we stop at the Newtonmore Highland Folk Museum, which houses replicas of 18th-century turf-roofed Highland crofts. These were used as a setting in the first season of the show.
Venturing further north we pass Aviemore, where you may recognise the stunning hilly and wooded area of Tulloch Ghru. This appeared during the journey Claire takes with Jamie and the Highlanders from Craigh na Dun to Castle Leoch.
You arrive in Inverness later in the afternoon.
Learn about the last battle fought on British soil at Culloden
Discover how whisky is made at a distillery in the Highlands
You first travel to Culloden. This site plays an important role in Scottish history and the Outlander books. It's not far from the battlefield where the couple said their tearful goodbyes before Jamie joined the Jacobite army to fight for the Stuarts. You have the opportunity to explore the visitor centre and site, and pay tribute to those who lost their lives at the last battle fought on British soil.
You then take a short drive to the ancient standing stones at Clava Cairns, which may have been the inspiration for Craigh na Dun.
After lunch, we continue to Castle Leod, "home of the Clan MacKenzie", where you can enjoy a relaxing walk while your guide tells you the history of the clan and area. The castle resembles how Diana Gabaldon described Castle Leoch, however she had never heard of this building prior to writing Outlander.
A short drive takes you to Beauly, the site of Beauly Priory and the tomb of Lord Lovat in the heart of Clan Fraser lands. Beauly Priory is a beautiful 13th-century ruin and where the Lovat Frasers are buried in Diana Gabaldon's book.
In the afternoon, you can sample 'The Water of Life' with a whisky distillery tour and tasting.
We return to Inverness with time to explore the town and enjoy the city for another evening.
Wander through the ancient indigenous forests of Glen Affric
Explore Inverness, the Capital of the Highlands
Your day starts with a visit to the majestic Glen Affric. Lochs, mountains and pine forests: this is one of Scotland's most glorious glens. It's also an ideal spot for Jamie to hide.
You then continue along the entire length of Loch Ness and through the Great Glen before heading to Glenfinnan. The monument here commemorates the beginning of the last Jacobite rising. It stands framed by Loch Shiel and bedside a famous section of the Jacobite Steam Train railway line, famously used as the Hogwarts Express in Harry Potter.
Your overnight stop is in Fort William underneath the shadow of Britain's tallest mountain, Ben Nevis.
Be moved by the sheer beauty of Glencoe
See two of Scotland's quintessential castles, Doune Castle and Blackness Castle
We start the day with a magnificent drive through Glencoe and cross the rugged Trossachs area onto Doune Castle. The Castle is an extensive ruin that represents Castle Leoch in the TV programme, home to Colum MacKenzie and his clan in the 18th-century episodes.
Later, you have a photo stop at Blackness Castle on the banks of the Firth of Forth. This was used as the set for Fort William in the show and appears in many other movies because of its beautiful setting and thickly fortified walls.
You return to Edinburgh in the early evening.
Once you've booked your tour, let us know if you want us to book this evening's Edinburgh accommodation.
What are the overnight locations on this journey?
Our Rail & Trail journeys are a combination of two our tours. You have a break between the trips where you spend free time in Edinburgh.
You stay two nights in Keswick*, two nights in Edinburgh, two nights in Inverness and one night in Fort William.
*Please be aware that Keswick is busy. You may need to be flexible with rooms we're able to reserve for you here. If you'd prefer to find your own accommodation for this location, please choose the 'book your own accommodation' option when you book your tour.
How does the accommodation work in Edinburgh?
When you book online, there's no option to select Edinburgh accommodation preferences.
But don't worry, we'll contact you once you've made your booking and give you an option to book Edinburgh hotel rooms with us. You're welcome to book the accommodation we suggest or arrange your own Edinburgh overnights.
How does the accommodation work on tour?
When you book online, we'll ask you for your accommodation preferences and get to work making reservations on your behalf. You'll pay your accommodation directly to hosts on tour (excluding Edinburgh). Most don't accept credit cards, so be prepared to pay cash.
You'll need to contact us with your accommodation details. Please only reserve accommodation within the overnight towns that your tour stops in. Your driver will drop you off at your chosen accommodation as long as it's relatively central (excluding Edinburgh).
You may be liable for the cost of your first nights' accommodation for each separate accommodation booked. If you cancel less than three days before departure, you may be liable for all your accommodation costs.
The prices below are for guidance only and exclude Edinburgh accommodation.
We try to reserve accommodation that's no more than a 20-minute walk from the town centre. We regularly check our accommodation suppliers to ensure they reach a certain standard.
B&B (Bed and Breakfast) Standard
The toilet and showering facilities are shared with at least one other room in the house, and the price includes breakfast. The cost is £35 - £50 per person per night based on shared accommodation. A single standard room is £40 - £70 per night.
Hotels have a bar or restaurant and provide evening meals. Breakfast is included in the price. The cost is £75 - £90 per person per night based on shared accommodation. A single is £90 - £150 per night.
A hostel consists of dormitory rooms with 4 to 16 bunk beds. The bathroom facilities are a short distance from the dorm room. Kitchen facilities are equipped so you can make your own meals. The cost based on dorm beds is £19 - £30 per person per night.
Please note that SYHA hostels only offer same gender dorms. Some independent hostels will offer mixed rooms (males and females together).
Where does the tour depart from?
Unlike our other Manchester tour departures, this tour departs from either Manchester Airport Railway Station or Manchester Piccadilly Railway Station. From either of these stations, you catch an Express service train and meet one of our driver-guides at Penrith Railway Station.
How do I get to Manchester Airport Railway Station or Manchester Piccadilly Railway Station?
Depending on where your Manchester accommodation is located, there are several ways to get to these stations. You can easily access these stations using the local or Intercity rail network, local buses, or by taxi. If you're travelling from Manchester Airport Railway Station you're within walking distance of the following hotels: Clayton Hotel, Radisson Blu, Crowne Plaza, Hilton Hotel, Holiday Inn Express, Marriott Hotel, Premier Inn. Manchester Piccadilly Station is in central Manchester and is within walking distance of many major hotel chains.
What time does the train depart?
The departure time of your train will vary depending on availability and season. We will email you with details of the exact train departure and arrival times prior to your tour. We recommend that you plan to arrive at the train station at least thirty minutes before your train departs. This will allow for travel delays should they occur on the way to the station and give you enough time to collect your tickets, locate your platform and purchase refreshments. It's important for you to arrive early because if you miss your train, you will be responsible for purchasing new tickets for the next departure.
Where do I collect my tickets?
In advance of your tour, we send you a unique ticket collection reference code. Please take this confirmation code with you when you collect your tickets. To collect your tickets at either railway station, just insert a credit or debit card into a ticket machine and enter your Ticket Collection Reference. If you have problems collecting your tickets, please go to a manned ticket window with your booking confirmation.
Do we have reserved seats?
In most cases, yes you have pre-assigned and reserved seats. If you booked your ticket within one week of departure, you may not have a seating reservation. If this is the case, you can choose from any of the unreserved seats on the train.
Can I buy food and drink on the train?
Yes, you can. The majority of services between Manchester Airport, Manchester Piccadilly and Penrith have a refreshment trolley service. If you require anything in particular, we recommend you pick up what you need from one of the various food and beverage outlets at your station of origin.
Which platform does the train leave from?
The platform changes every day. Please keep an eye on the departure boards in the main terminal. From both Manchester Airport Railway Station and Manchester Piccadilly Railway Station, your train is the service for Glasgow Central train station. The correct departure time will be printed on your ticket, and correspond to the time on the departure board. The platform will be announced about 10 minutes before departure so please make your way to the train once you have seen which platform the train is departing from.
What happens if the train is cancelled?
If your train is cancelled, your ticket is valid on the next departure, however you'll not have reserved seats. If this happens, please contact the Rabbie's customer service team on +44(0)131 226 3133, so we can advise the guide and ensure they're there to pick you up at the new time.
How long is the train trip?
The train takes 1 hour and 47 minutes from Manchester Airport and 1 hour 36 minutes from Manchester Piccadilly to Penrith Station.
Where do we meet the tour bus?
Your Rabbie's driver-guide will meet you outside Penrith Station with other guests who started the tour in Edinburgh or London. Penrith Station is small, and you will see your bus waiting for you just outside the station. If you do have problems finding your bus just give us a call on +44(0)131 226 3133.


Metaglossary.com - Definitions for "all wheel drive"
Definitions for "ALL WHEEL DRIVE"
All four wheels are driven by the engine. AWD systems are superior to 4WD as AWD can be used under any road conditions.
Taken literally AWD means all four wheels can be driven, but there is some ambiguity as to just what "driven" means. If a centre diff' is used between the front and rear axles then all wheels share equal torque (unless one slips and an LSD or diff' lock takes over). A cheaper arrangement is to drive one axle via a viscous coupling or similar. In this case one axle receives no torque until the other axle slips - is this all wheel drive? Debatable.
all wheels provide driving force to enhance traction in inclement weather or when spirited driving is wanted. On-road all-wheel-drive systems are biased for sporty driving in clear to moderately inclement conditions. Four-Wheel-Drive or 4x4 systems are usually found on pickup trucks and SUVs and are capable of driving off-road in very challenging conditions.
Term used to describe a full time four wheel drive system or any other car drive system that continuously delivers power to all four wheels. This system is found primarily on station wagon cars and SUVs not utilized for significant off road use.
This is where all the wheels are utilized as active drive wheels for greater control in challenging road conditions. It works by dividing up the engine torque between the front and rear wheels in varying amounts depending on the needs. AWD is designed as an on-road control system and is therefore not the same as Four Wheel Drive (4WD or 4x4). (See also Torque).


If you wish to be informed of Baroque Voices activities, please sign up here - remember to send us your postal address if you wish to receive our brochure. You can unsubscribe at any time by sending an email through the "unsubscribe" link. Of course you are also welcome to pass on a personal message!
receive brochure by mail - please don't forget to enter your name and postal address!


text:
Important Case Documents
About Class Counsel
The following are important dates that will affect your rights:
Deadline for Submitting a Claim: February 17, 2022. Detailed Instructions on submitting a claim can be found here.
Deadline for Requesting Exclusion: November 15, 2021. If you ask to be excluded, your financial institution will not get any payment as part of this Settlement, and you cannot object to this Settlement. Your financial institution will not be legally bound by anything that happens in the Settlement and related proceedings. Your financial institution may be able to sue (or continue to sue) Hudson's Bay in the future. If you object to the Settlement and seek to exclude your financial institution, you will be deemed to have excluded your financial institution. Detailed instructions on how to exclude your financial institution from the Settlement can be found here.
Deadline for Submitting an Objection: November 15, 2021. If your financial institution is a Settlement Class Member, you can object to the Settlement if you do not think it is fair, reasonable, or adequate. You can give reasons why you think the Court should not approve it. The Court will consider your views. If you both object to the Settlement and seek to exclude your financial institution, your financial institution will be deemed to have excluded itself and your objection will be deemed null and void. Detailed instructions for objecting to the settlement can be found here.
Deadline for Objectors to File Response to Final Approval Motion and Fee Application: November 29, 2021. Class Counsel has a deadline of November 1, 2021, to file a motion for final approval of the Settlement and a motion for attorneys' fees, costs, and expenses and for Service Awards. Objectors, if any, have until November 29, 2021, to file any response to Class Counsel's motions.
Final Approval Hearing: December 7, 2021 at 2:30 p.m. The Court will hold a Final Approval Hearing at 2:30 p.m. on December 7, 2021, in Courtroom 11D before Senior United States District Judge P. Kevin Castel of the United States District Court for the Southern District of New York, at the Daniel Patrick Moynihan United States Courthouse, 500 Pearl St., New York, NY 10007-1312, or at such other time, location, and venue as the Court may Order. This hearing date and time may be moved. Please refer to the Settlement Status page for notice of any changes. At the Final Approval Hearing, the Court will consider, among other things, whether the Settlement is fair, reasonable, and adequate; how much Plaintiffs' lawyers will receive as attorneys' fees and costs and expenses; and whether to approve service awards to the Settlement Class Representatives. If there are objections, the Court will consider them. The Court will listen to people at the hearing who file in advance a timely notice of their intention to appear (see instructions here). At or after the Final Approval Hearing, the Court will decide whether to approve the Settlement. There is no deadline by which the Court must make its decision.
© 2023 . Analytics Consulting LLC Privacy Policy and Terms of Use

redpajama_set_name: RedPajamaCommonCrawl


text:
Q: Enter value to textArea on IE with PowerShell I have a PowerShell script that open Internet Explorer browser at specific URL.
I know how to refer to specific elements ant to enter values to textBox (See at the code on the bottom).
But when I used this code on textArea, the data I am enter isn't inserted to the textArea.
PLS help me.
thanks in advance
$userNameID = "ctl00_MainContent_login_control_UserName"
$passwordID = "ctl00_MainContent_login_control_Password"

$loginButton = "ctl00_MainContent_login_control_LoginButton"
$phonesID = "ctl00_MainContent_reciSel_TabsContacts_tabFromFile_txtFromFile"
$sendSmsButton = "ctl00_MainContent_btn_SaveAndSave"
$messageBoxID = "ctl00_MainContent_txt_ContentText"
$confirmButton = "ctl00_MainContent_ButtonOk"

$IE=new-object -com internetexplorer.application
$IE.visible = $true
$IE.navigate2("myUrl")
while($IE.Busy) { Start-Sleep -Milliseconds 100 }

**#this works on this element:**
$IE.Document.getElementByID($userNameID).value = "user name"
**#this works on this element:**
$IE.Document.getElementByID($passwordID).value= "password"

$IE.Document.getElementByID($loginButton).Click()
while($IE.Busy) { Start-Sleep -Milliseconds 100 }

**#Does not work on this element:**
$IE.Document.getElementById($messageBoxID).value = $messageToSend

redpajama_set_name: RedPajamaStackExchange


World War II brought death to more than 300,000 Americans who were serving their country overseas. While the war was on, most of these honored dead were buried in temporary US military cemeteries.
Several temporary cemeteries were constructed – one was in lower Hālawa Valley, overlooking Pearl Harbor.
Following the war, Congress passed, and the President signed, a bill that authorized the War Department to take steps to provide a reverent final burial for those who gave the last full measure of devotion.
In September 1947, the American Graves Registration Service (AGRS) disinterred and moved the remains to the Schofield Barracks Central Identification Laboratory (Schofield CIL), located at the AGRS Pacific Zone Headquarters, in order to effect or confirm identifications and return the men to their next of kin for burial.
The image shows Hālawa Naval Cemetery. (Babcock) In addition, I have added other images in a folder of like name in the Photos section on my Facebook and Google+ pages.
The Hawaiian Islands are made up of one or more shield volcanoes that are composed primarily of extremely permeable, thin basaltic lava flows (within the flows are a few ash beds.) Ordinarily, basalts are among the most permeable rocks on earth.
The latter contributes to the groundwater recharge of the area (in the Koʻolau, it takes about 9-months for the rain, now groundwater, to seep down through cracks and permeable materials in the mountain.) Other recharge components include cloud drip (moisture condenses on the trees and leaves as clouds/fog drift through) and irrigation of an area helps add to the recharge.
Rainfall percolating through the ground may accumulate in three principal types of groundwater bodies: (1) high-level bodies perched on relatively impervious soil, ash or lava layers; (2) high-level bodies impounded within compartments formed by impermeable dikes that have intruded the lava flows; and (3) basal water bodies floating on and displacing salt water.
The principal source of fresh ground water in the Hawaiian Islands is the roughly lens-shaped basal water body floating on and displacing denser sea water. (It varies by area, sometimes there is high-level confined water.) Recharge of the basal water body results directly from percolating rain water or by underground leakage from perched-water bodies and bodies impounded by dikes.
North Hālawa Valley overlies the Pearl Harbor aquifer, an important source of potable water for the island of Oʻahu. Freshwater in the Pearl Harbor aquifer is part of a large, lens-shaped body of ground water that is thickest in the central part of Oahu and thins toward the coastline.
In some early installations, vertical wells were drilled in the tunnels to develop additional water. Hālawa was different; it is referred to as a skimming tunnel. It's commonly called the Hālawa Shaft.
The fundamental advantage of the skimming tunnels over conventional wells is their capability to produce large quantities of fresh water from lenses so thin that drilled wells would recover only brackish water.
For this reason, skimming tunnels are especially useful in some of the dry leeward coastal areas of Hawaiʻi, as well as on many small oceanic islands with extremely thin fresh-water lenses.
Approximately 15-million gallons of pure water is pumped every day from the Hālawa shaft by three pumping units which have a capacity of 18 to 20-million gallons per day.
The completion of the Hālawa Shaft made possible the importation of water from the Pearl Harbor area to Honolulu permitting a reduction in draft from the Honolulu aquifer.
While I was at DLNR, I had the opportunity to have a private tour of the Hālawa Shaft. The lack of a key to unlock a gate on the stairs leading down the shaft caused quite an embarrassment to the Water staff.
The image shows a simple water level gauge at the water pool at the Hālawa Shaft. In addition, I have included other related images in a folder of like name in the Photos section on my Facebook and Google+ pages.


text:
Chase Utley: Thumb "Not Bothering Me At All"
By Jason Brewer Aug 16, 2010, 11:39am EDT
Share All sharing options for: Chase Utley: Thumb "Not Bothering Me At All"
Chase Utley will play twice today as part of the Clearwater Thresher's doubleheader and then will fly back to Philadelphia to re-join the Phillies. Utley says his thumb is healed.
"My thumb feels good," Utley said. "It's not bothering me at all. I don't know what the plans will be after that. I'll have to discuss that with [manager] Charlie [Manuel] and [general manager Ruben] Amaro and go from there."
With the thumb healed, all that remains for Utley is to get his timing back.
"I know I could use a few more plate appearances," he said. "The big thing is just getting into the flow again and making sure my timing is down in the batter's box."
Phillies Activate Chase Utley From The DL
Phillies Activate Chase Utley From DL
Chase Utley Could Rejoin Phillies Tuesday To Face Giants


text:
package com.intive.intivemvpframework.internal.di.components;

import com.intive.intivemvpframework.internal.di.PerActivity;
import com.intive.intivemvpframework.internal.di.modules.ActivityModule;
import com.intive.intivemvpframework.view.fragment.UserDetailsFragment;
import com.intive.intivemvpframework.view.fragment.UserListFragment;

import android.app.Activity;

import dagger.Component;

/**
 * A base component upon which fragment's components may depend.
 * Activity-level components should extend this component.
 *
 * Subtypes of ActivityComponent should be decorated with annotation:
 * {@link com.intive.intivemvpframework.internal.di.PerActivity}
 */
@PerActivity
@Component(dependencies = ApplicationComponent.class, modules = ActivityModule.class)
public interface ActivityComponent {

    //Exposed to sub-graphs.
    Activity activity();

    void inject(UserListFragment userListFragment);

    void inject(UserDetailsFragment userDetailsFragment);
}

redpajama_set_name: RedPajamaGithub


European standard S275JR H profile steel, steel,Hot sell European standard S275JR H profile steel, Steel Plates Thickness and Weights stock in China,China European standard S275JR H profile steel, Steel Plates Thickness and Weights factory. Keeps more than 10,000 tons hot rolled and cold rolled European standard S275JR H profile steel, Steel Plates Thickness and Weights in stock each month. We can meet our customer's any quantity request. Based on these stock source, our advantage industry spread into steel process like : cutting ( any size and any shape ) drilling, welding, milling, machining and steel structure. We also have a high quality logistics team who make sure the fast delivery time and shipment. Anyway, if you want to find European standard S275JR H profile steel, Steel Plates Thickness and Weights plate/sheet supplier, European standard S275JR H profile steel, Steel Plates Thickness and Weights plate/sheet bar manufacturer, European standard S275JR H profile steel, Steel Plates Thickness and Weights plate/sheet bar exporter, please contact steel's sales team. We will give you the European standard S275JR H profile steel, Steel Plates Thickness and Weights plate competitive price, European standard S275JR H profile steel, Steel Plates Thickness and Weights plate good quality and best service from us.
European Standard Beams,Heb,Ipe,Iupn,Upn Steel Beams , Find Complete Details about European Standard Beams,Heb,Ipe,Iupn,Upn Steel Beams,Factory Supply Galvanized Steel H Beam, E Structural Carbon Steel H Beam Profile H Beam,S275jr Heb Steel Beams from Supplier or Manufacturer Tianjin JMS Steel Co., Ltd.
S275JR Steel Grade, Mechanical Properties, Chemical Composition, Grade Equivalent StandardEN 10025 2:2004, European standard for hot rolled structural steel. Part 2 Technical delivery conditions for non alloy structural steels.
HEB beams, European standard wide flange H beams, dimensions, specifications. HE B beams in accordance with former standard Euronorm 53 62. Current table represents European standard wide flange H steel beams specifications.
IPE I beam S275JR I beam price hot dip galvanized steel beam . The IPE European I beam provided is a kind of hot rolled steel profile which is manufactured according to European standards EN 10034 and EN10025. IPE European I beams are also called "H beams", "H sections", "steel W section I beams" and "wide flange sections".
Home >Product list > European standard S275J2 angle bar stock. processing property, be rolled into steel plates, shaped steel and profile steel, which usually used to build workshop, bridge, vessels and so on. Read more; s275j2 Boiler and Pressure Vessel Steel Plate. S235 material can be supplied in S275JR, S275J0, S235J2W.
S275JR Steel Plate EN 10025 2 2004 Technical S235JR, S235J0, S235J2, S355JR, S355J0, S355J2, S355K2, S450J0 steel grade . S275JR steel plate . Steel Plates According to EN 10025 2 Steel Exporter EN 10025 2004 is the new six part European standard for hot rolled structural steel.
Steel Beam, Steel Profile, Steel Building manufacturer / supplier in China, offering European Standard Steel H Beams From China Tangshan Manufacturer, Hot Rolled Steel I Beam From Jin Xi Steel, Hot Rolled Steel I Beam From Jinxin and so on.


text:
Call for Submissions: Special Issue on Thomas McGrath
For almost 50 years, North Dakota Quarterly published work by and about the poet Thomas McGrath. Now NDQ plans to celebrate the 100th anniversary of his birth, November 20, 2016, with an issue devoted to him and his work. This call for papers seeks previously unpublished material about McGrath as
On the Radio: NDQ on Prairie Public's Main Street
We should hear poetry read. With almost every issue of North Dakota Quarterly, Bill Thomas, the Director of Radio at Prairie Public Radio, reads some of the most recent issue. Check it out on Main Street at the 27 minute mark.
Short Take: Bureaucracies in a Transnational Perspective
Sharon Carson Ahmet Hamdi Tanpinar, The Time Regulation Institute. Introduction by Pankaj Mishra. Translated from the Turkish by Maureen Freely and Alexander Dawe. Penguin Books, 2013. These days it's not hard to imagine someone writing a satiric novel about the recent North Dakota oil boom. It could easily include a send-up
North Dakota Quarterly and Budget Cuts: What Can You Do?
We'd like to thank everyone who has sent notes of support, words of encouragement, and thoughts our way as we begin to look ahead toward a new future for North Dakota Quarterly. We particularly appreciate the willingness of subscribers, contributors, and colleagues to be part of this process. To keep
North Dakota Quarterly and the Budget Cuts at the University of North Dakota
North Dakota Quarterly, an interdisciplinary public humanities journal published at the University of North Dakota for more than 83 years, has been notified that it will lose its funding in the current wave of budget cuts at UND. Effective August 15th, NDQ will no longer have salary for its managing
New Issue: North Dakota Quarterly 83.1
North Dakota Quarterly is pleased to announce the release of our newest issue, Volume 83.1. Chuck Kimmerle's lovely black and white photographs point to the chilly and sometimes chilling themes found in this Winter issue. On the cover, lines of leafless trees stand against the bleak backdrop of snow covered
Podcast: Kim Stanley Robinson and Archaeological Science Fiction
This week, we're being a little experimental and expanding the media that appears on the NDQ page. We're collaborating with the Caraheard podcast to bring some audio goodness to our readers. Enjoy! Bill Caraher and Richard Rothaus were lucky enough to have a chance to sit down with Kim Stanley
Poetry: Subtraction and the Body is No Scientist by Katharine Coles
Two poems by Katharine Coles from NDQ 80.4-82.4. She's a featured speaker at this years University of North Dakota Writers Conference. Subtraction Katharine Coles The black art of "borrowing" . . . is only a little more baroque than that of "carrying." Steven Stogatz, The New York Times Hard to
Short Take: Rare Views of Natural History
Kathryn Sweney The UND Writers Conference starts tomorrow. Its theme—"The Art of Science"—is the perfect excuse to point out a book that is the very embodiment of that theme: Tom Baione ed., Natural Histories: Extraordinary Rare Book Selections from the American Museum of Natural History Library (New York 2014). Check out some of
The University of North Dakota Writers Conference
This week is the 47th annual UND Writers Conference. It gives us a chance here at North Dakota Quarterly headquarters to rub shoulders with some of our contributors and to meet some genuinely exceptional writers read their works and talk about the craft of writing. This year's theme, "The Art


text:
Tatra T7B5 (podtyp tramvaje T7) je model tramvaje vyráběný společností ČKD Praha, závod Tatra Smíchov na přelomu 80. let a 90. let 20. století.

Konstrukce

T7B5 je jednosměrný čtyřnápravový motorový tramvajový vůz, který koncepčně vycházel z vozů Tatra T6B5; oba typy měly i podobné rozměry vozové skříně. Hmotnost celého vozu se ale zvětšila, přiblížila se 20 tunám, což bylo velkou nevýhodou tohoto typu. Byly také použity podvozky s dvojím vypružením. Tramvaj je vybavena elektrickou výzbrojí typu TV3 s tyristorovou regulací.

Prototypy
První dva prototypy (čísel 0024 a 0025) se v Praze objevily v roce 1988. Po řadě zkoušek byl vůz č. 0024 odstaven v pražské vozovně Hloubětín. Zde zůstal až do 7. října roku 2001, kdy byl správcem konkurzní podstaty zkrachovalé společnosti ČKD Dopravní systémy prodán firmě, která vůz rozebrala, některé díly využila a zbytek vozu sešrotovala.

Vůz č. 0025 byl roku 1991 rekonstruován a prodán do norského Osla, kde obdržel evidenční číslo 200. Roku 1995 obdržel nové evidenční číslo 321 a byl používán pro vyhlídkové jízdy. V roce 1998 byl pro nedostatek zaměstnanců odstaven a ještě téhož roku se dostal do švédského města Göteborg, kde pod číslem 100 jezdí dodnes jako vyhlídkový vůz.

Další dva prototypy tramvaje T7B5 (čísla 0026 a 0027 vyrobené 1989) jezdily krátkou dobu také v Praze, ale brzy byly předány ke zkouškám do Moskvy, kde již zůstaly. V roce 1990 byly označeny ev.č. 7001 a 7002 a nasazeny do pravidelného provozu. Roku 1994 byly vozy opět přečíslovány na 3321 a 3322. Vůz ev. č. 3322 byl odstaven roku 2002 a sloužil jako zdroj náhradních dílů a sklad. Třetí prototyp si v roce 2003 vyměnil evidenční číslo se sériovým vozem č. 3326 (pův. č. 7006) a s tímto označením v pravidelném provozu dojezdil v roce 2005, kdy se stal exponátem moskevského tramvajového muzea.

Dodávky tramvají
V letech 1988 až 1993 bylo vyrobeno celkem osm vozů.

Odkazy

Reference

Externí odkazy

 Článek o tramvajích typu T7B5
 Fotogalerie vozů T7B5 v Moskvě
 Poslední prototyp ČKD v pražských ulicích (popis a fotografie z převozu pražského kusu ev. č. 0024 z hloubětínské vozovny na kolejové propojení zličínského nádraží)

T7B5
Kolejová vozidla vyráběná od roku 1988
Kolejová vozidla vyráběná do roku 1993

redpajama_set_name: RedPajamaWikipedia


Check back here for the latest news on our groups and upcoming events.
Gamin' Gals l 2nd Friday of the month l 7:00 p.m.
Play fun games, eat great food, and laugh out loud with us! We enjoy classics like Dominos and Bunco, but are also always looking for new games, too. You may even go home with a great prize!
We gather together to work on items to donate to the Mennonite Central Committee, and other projects for our community. We give free lessons!
To get connected to any of these groups, please email women@firstmbchurch.org.


text:
Revenue of the cosmetic industry in the U.S.
Value of the leading 10 textile exporters worldwide
Vegetable oils: global consumption by oil type 2013/14 to 2019/2020
Cocoa bean production worldwide 2018/19 & 2019/20, by country
World coffee per capita consumption: major consumer countries
Cosmetics Industry in the U.S. - Statistics & Facts
Coca-Cola Company - statistics & facts
Consumer Goods & FMCG›
Champagne purchases for home consumption by channel in France 2015
Published by Statista Research Department, Mar 1, 2016
This chart highlights the breakdown of purchases of champagne for home consumption in France in 2015, by channel. More than 66 percent of champagne purchases for home consumption took place in supermarkets.
Champagne purchases for home consumption in France in 2015, by channel
Breakdown of champagne purchases
* Hypermarket-Supermarket.
** Hard discount.
*** The source gives no information regarding this answer.
Supermarkets and grocery stores: quarterly e-commerce revenue in Spain 2014-2019
Number of employees of Hipercor S.A. in Spain 2011-2016
Number of employees of Mercadona in Spain 2012-2019
Number of employees of Carrefour in Spain 2011-2019
Statistics on "Leading supermarkets in Spain"
Sales share of the biggest supermarkets in Spain 2019
Employee volume in large supermarkets in Spain in 2019
Average annual salary in main supermarket chains in Spain 2020
Most stolen food products in food stores in Spain 2017, by type
Food sales share by distribution channel in Spain in 2019
Supermarkets and food stores: e-commerce transactions in Spain 2019
Sales volume of Mercadona in Spain 2013-2019
Sales value of Mercadona in Spain 2014-2019
Net profit of Mercadona in Spain and Portugal 2010-2019
Mercadona's annual investment in Spain 2013-2019
Mercadona shops in Spain 2010-2019
Share of employees of Mercadona by type of contract in Spain 2012-2019
Mercadona EBITDA margin in Spain and Portugal 2010-2019
Sales value of Carrefour in Spain 2013-2019
Sales value of the supermarket chain DIA in Spain 2014-2019
Number of employees of the supermarket chain DIA in Spain 2010-2019
Number of supermarkets of Grupo DIA in 2019, by country
Sales value of Eroski in Spain 2014-2019
Sales value of Lidl in Spain 2014-2019
Sales value of Alcampo in Spain 2012-2018
Number of supermarkets of Consum in Spain 2019, by region
Number of employees of Caprabo in Spain 2011-2019
Sales value of Sabeco in Spain 2012-2017
Sales channels of cosmetics and beauty products in the U.S. 2011
Revenue of Unilever in the United States from 2006-2011
Sales channels luxury watch brands will focus on 2017
Market share of bottled water in CHD by sector in France 2014
Brazil: wholesale sales 2018-2019, by model & channel
Share of retail spend in Germany 2013-2018, by channel
Value sales of champagne in supermarkets by type in France 2016
Number of champagne promotions at major food retailers United Kingdom (UK) 2016
Champagne purchases in volume in France 2018, by sales channel
Revenues from wine in Germany 2008-2014, by sales channel
Champagne sales volume by type of brand in France 2015
Sales volume of champagne in Germany 2000-2019
Sales value of ice cream in Italy 2019, by sales channel
Sales volume of most popular champagne brands in France 2015
Consumers purchasing chocolate online in the United Kingdom (UK) 2015
Price of wine in Germany 2008-2014, by sales channel
Supermarkets in Mexico Food industry in Brazil Food industry in Mexico Supermarkets in the U.S. Supermarkets in the United Kingdom (UK)
CIVC. (March 1, 2016). Champagne purchases for home consumption in France in 2015, by channel [Graph]. In Statista. Retrieved January 21, 2021, from https://www.statista.com/statistics/767437/champagne-purchases-for-home-consumption-by-channel-in-france/
CIVC. "Champagne purchases for home consumption in France in 2015, by channel ." Chart. March 1, 2016. Statista. Accessed January 21, 2021. https://www.statista.com/statistics/767437/champagne-purchases-for-home-consumption-by-channel-in-france/
CIVC. (2016). Champagne purchases for home consumption in France in 2015, by channel . Statista. Statista Inc.. Accessed: January 21, 2021. https://www.statista.com/statistics/767437/champagne-purchases-for-home-consumption-by-channel-in-france/
CIVC. "Champagne Purchases for Home Consumption in France in 2015, by Channel ." Statista, Statista Inc., 1 Mar 2016, https://www.statista.com/statistics/767437/champagne-purchases-for-home-consumption-by-channel-in-france/
CIVC, Champagne purchases for home consumption in France in 2015, by channel Statista, https://www.statista.com/statistics/767437/champagne-purchases-for-home-consumption-by-channel-in-france/ (last visited January 21, 2021)


text:
Row erupts over Brazil suspension of Chinese vaccine trials
Issued on: 10/11/2020 - 17:30 Modified: 10/11/2020 - 17:28
Brasília (AFP) –
Brazil's decision to halt trials of a Chinese-developed Covid-19 vaccine triggered a politically charged row Tuesday as health officials expressed "indignation" over the move and far-right President Jair Bolsonaro claimed it as a victory.
Brazilian health regulator Anvisa announced late Monday it was suspending clinical trials of CoronaVac, developed by Chinese pharmaceutical firm Sinovac Biotech, after a "severe adverse incident" involving a volunteer in the study.
Privacy regulations prevent officials from disclosing details on the incident, which came as a setback for one of the most promising vaccines aiming to end the pandemic.
However Brazilian media reports said the fatality was a suicide, citing a leaked death certificate.
Both Sinovac and the public health institute coordinating the study in Brazil said the incident had nothing to do with the vaccine.
"There is no relation with the vaccine," said Dimas Covas, head of the Butantan Institute, the respected public health center coordinating the study in Brazil.
"We can't go into details because of privacy regulations, but what I can tell you is that Anvisa has all the data, all the information in its hands, and the conclusion from the (independent expert) report is exactly that: There is no link with the vaccine," he told a news conference.
Anvisa's decision, he said, "came as a surprise... and caused indignation here at Butantan."
Bolsonaro, who has railed against CoronaVac as the vaccine from "that other country" and blocked the federal government from purchasing it, meanwhile said he considered the regulatory decision "another win for Jair Bolsonaro."
CoronaVac has been caught up in a messy political battle in Brazil, where its most visible backer has been Sao Paulo Governor Joao Doria, a leading Bolsonaro opponent.
Sao Paulo state has a deal with Sinovac to buy a total of 46 million doses -- six million produced in China and the rest produced in Sao Paulo, which broke ground last week on a factory to make the vaccine domestically.
Bolsonaro has thrown his support behind another vaccine, developed by Oxford University in Britain and the pharmaceutical firm AstraZeneca.
Bolsonaro faces criticism from experts for his handling of the pandemic, which has included playing down the virus, opposing lockdown measures and relentlessly promoting the drug hydroxychloroquine despite studies showing it is ineffective against Covid-19.


Jump-Hurdle-Jumping-Rope-Play-Exercise-Girl-Free-I-7670.jpg is totally free to download without any copyright so you can use it privately or commercially without any attribution however a link back to this post is appreciated. The uploader to PixCove has waived all rights to this image, so is free to use anywhere under Creative Commons Deed CC0.
To download Jump-Hurdle-Jumping-Rope-Play-Exercise-Girl-Free-I-7670.jpg right mouse click on the above image and choose "Save Image as…." from the menu and save it to your desktop.
Inside WPG navigate to your desktop and double click on Jump-Hurdle-Jumping-Rope-Play-Exercise-Girl-Free-I-7670.jpg then click "Auto adjust" in the menu.
Snow-Snowflake-Hike-Shoes-Winter-Free-Image-Sport–9048.jpg is totally free to download without any copyright so you can use it privately or commercially without any attribution however a link back to this post is appreciated. The uploader to PixCove has waived all rights to this image, so is free to use anywhere under Creative Commons Deed CC0.
To download Snow-Snowflake-Hike-Shoes-Winter-Free-Image-Sport–9048.jpg right mouse click on the above image and choose "Save Image as…." from the menu and save it to your desktop.
Inside WPG navigate to your desktop and double click on Snow-Snowflake-Hike-Shoes-Winter-Free-Image-Sport–9048.jpg then click "Auto adjust" in the menu.
Explosions-Bangs-Exercise-Panzer-War-Fire-Free-Ima-3391.jpg is totally free to download without any copyright so you can use it privately or commercially without any attribution however a link back to this post is appreciated. The uploader to PixCove has waived all rights to this image, so is free to use anywhere under Creative Commons Deed CC0.
To download Explosions-Bangs-Exercise-Panzer-War-Fire-Free-Ima-3391.jpg right mouse click on the above image and choose "Save Image as…." from the menu and save it to your desktop.
Inside WPG navigate to your desktop and double click on Explosions-Bangs-Exercise-Panzer-War-Fire-Free-Ima-3391.jpg then click "Auto adjust" in the menu.
Stairs-Staircases-Brick-Stone-Exercise-Free-Image–5188.jpg is totally free to download without any copyright so you can use it privately or commercially without any attribution however a link back to this post is appreciated. The uploader to PixCove has waived all rights to this image, so is free to use anywhere under Creative Commons Deed CC0.
To download Stairs-Staircases-Brick-Stone-Exercise-Free-Image–5188.jpg right mouse click on the above image and choose "Save Image as…." from the menu and save it to your desktop.
Inside WPG navigate to your desktop and double click on Stairs-Staircases-Brick-Stone-Exercise-Free-Image–5188.jpg then click "Auto adjust" in the menu.
Active-Lively-Athletics-Activity-Play-Free-Image-B-3775.jpg is totally free to download without any copyright so you can use it privately or commercially without any attribution however a link back to this post is appreciated. The uploader to PixCove has waived all rights to this image, so is free to use anywhere under Creative Commons Deed CC0.
To download Active-Lively-Athletics-Activity-Play-Free-Image-B-3775.jpg right mouse click on the above image and choose "Save Image as…." from the menu and save it to your desktop.
Inside WPG navigate to your desktop and double click on Active-Lively-Athletics-Activity-Play-Free-Image-B-3775.jpg then click "Auto adjust" in the menu.
Active-Lively-Court-Ball-Player-Free-Image-Exercis-8241.jpg is totally free to download without any copyright so you can use it privately or commercially without any attribution however a link back to this post is appreciated. The uploader to PixCove has waived all rights to this image, so is free to use anywhere under Creative Commons Deed CC0.
To download Active-Lively-Court-Ball-Player-Free-Image-Exercis-8241.jpg right mouse click on the above image and choose "Save Image as…." from the menu and save it to your desktop.
Inside WPG navigate to your desktop and double click on Active-Lively-Court-Ball-Player-Free-Image-Exercis-8241.jpg then click "Auto adjust" in the menu.


Hello and happy Friday! So, maybe you've seen this collection floating around...maybe you haven't. If you haven't, let me be the FIRST to talk to you about these polishes.
Ever since creating my blog almost 2 years ago, I've made some pretty awesome blogger/vlogger friends. They are some the sweetest ladies I know and I love to support them when my wallet allows me to. The moment that Jess from Love for Lacquer posted that she was collaborating with Nailtini, I knew I had to grab these shades. Keep reading to see if the purchase was worth it!
Look at Jess's face in my Nailtini Lacquer Cabinet box! I think i may have squealed a little and said, "I kinda know her!" when I got the package in the mail.
Jess designed three shades that are shown below. When you purchase this set, it also comes with 2 mini bottles where you can mix your own shades. As much as I love frankening, I honestly don't think I'd mess with these colors. Did I give away my opinions already?? Okay, let's just get right to it. Below are my swatches.
Jess, I hope my nails can do these polishes justice!
First up is Bubbles & Berries. It is described as a deep berry purple awash with gold shimmer. Yes, yes it is! I applied 2 coats. With 2 even coats, this polish is AMAZING! The formula has a great consistency and the color just pops right on my nails! Love it! It's definitely perfect for fall or any evening affair.
The second polish in this collection is Lady Grey. It's described as a sophisticated dark grey cream. I am FLOORED by how creamy this color actually is. I don't have many grey creams in my collection and I'm actually very happy to add this one to the stash. It applied flawlessly in 2 even coats. I might also mention that I love the long brushes that these polishes have. Makes applying polish easier for me.
This last polish, I have to admit, was scary to me. Usually when I see that a polish has different dimensions to it...it usually doesn't show up on the nail and is very sheer. Imagine my surprise when this polish was most definitely opaque in 2 coats AND showed off the color shift. YAY! This polish is called Alchemist Punch and is described as a muted turquoise with orchid travel.
So, what do you think? I absolutely LOVE these shades and i am so happy I bought it! You can get this entire set for just $25 HERE. Let me know if you have this already or if you're planning on getting it! Not sure how long it's going to be available so get moving if you want it!
*Purchased by me. All opinions are 100% honest and my own.
Alchemist Punch is my absolute favorite, lovely swatches!
These polishes are SO gorgeous!! Hard to pick a fave!
These are SO gorgeous! Bubbles & Berries is my fave!
Love bubbles and berries. Great swatches.
These are beautiful! Great for fall too.
I love this collection - great job, Jess!
Bubbles & Berries looks so pretty!
Nice shades! I love the grey!
I am obsessed with Lady Grey!
They are certainly beautiful! I love a shimmer.
I love the first two shades, but that blue is all wrong for me.
They are gorgeously swatched but I don't think these colours are for me.
Ohh i have never seen this brand before, but let me tell you, that Bubbles & Berries looks fantastic. Such a great deep color & one of the best shades for fall in my opinion.
This is a cute set! Very nice color picks for fall!


text:
Q: MYSQL not getting the sum zero values (having no entries of that id) against distinct id of another table SELECT d.millid, d.bookno, d.partyname, d.count,
       d.counttype, d.orderqty, d.dispqty, d.pending
from ( SELECT b.millid, b.count, b.counttype, b.bookno, b.partyname,
              COALESCE(b.bags,0) as orderqty,
              COALESCE(sum(y.bags),0) as dispqty,
              COALESCE((b.bags-sum(y.bags)),0) as pending
       from yarnDispatch y
       JOIN yarnbook b ON b.bookno=y.bookno
       GROUP by b.bookno) d
WHERE d.pending>0
ORDER BY d.millid, d.bookno

In this query, table yarnbook is master table, having unique bookno (Booking Nos) from 1 to 2600 (and on) and other table yarndispatch have several or zero dispatch (bags) entries against the each of the same bookno (yarnbook).
When I'm running this query, giving the correct result where there is atleast single dispatch entry against bookno, but not giving (sum(bags) as 0) where there is no entry of dispatch in yarndispatch table.
Please share your views/solution.

A: You need to perform an outer join, which preserves data in the case where one table has data and the other table does not, instead of an inner join which only returns rows if data is present in both tables.
Saying JOIN is equivalent to INNER JOIN. Replace JOIN with LEFT OUTER JOIN and your results should be more in line with what you want.

A: You need a LEFT JOIN or RIGHT JOIN  to get the "empty" rows
SELECT d.millid, d.bookno, d.partyname, d.count,
       d.counttype, d.orderqty, d.dispqty, d.pending
from ( SELECT b.millid, b.count, b.counttype, b.bookno, b.partyname,
              COALESCE(b.bags,0) as orderqty,
              COALESCE(sum(IFNULL(y.bags,)),0) as dispqty,
              COALESCE((b.bags-sum(y.bags)),0) as pending
       from yarnDispatch y
       RIGHT JOIN yarnbook b ON b.bookno=y.bookno
       GROUP by b.bookno) d
WHERE d.pending>0
ORDER BY d.millid, d.bookno

Both joins are interchangeble but some peolple prefer LEFT JOIN
SELECT d.millid, d.bookno, d.partyname, d.count,
       d.counttype, d.orderqty, d.dispqty, d.pending
from ( SELECT b.millid, b.count, b.counttype, b.bookno, b.partyname,
              COALESCE(b.bags,0) as orderqty,
              COALESCE(sum(IFNULL(y.bags,0)),0) as dispqty,
              COALESCE((b.bags-sum(y.bags)),0) as pending
       from
       yarnbook b
        LEFT JOIN yarnDispatch y ON b.bookno=y.bookno
       GROUP by b.bookno) d
WHERE d.pending>0
ORDER BY d.millid, d.bookno

A: Thank you for your valuable reply;
I've tried following query and it is working;
    SELECT
    d.millid,
    d.bookno,
    d.partyname,
    d.count,
    d.counttype,
    d.orderqty,
    d.dispqty,
    (d.orderqty - d.dispqty) AS pending
FROM
    (
    SELECT
        b.millid,
        b.count,
        b.counttype,
        b.bookno,
        b.partyname,
        COALESCE(b.bags, 0) AS orderqty,
        Y.bags,
        COALESCE(SUM(Y.bags),
        0) AS dispqty
    FROM
        yarnDispatch Y
    RIGHT JOIN yarnbook b ON
        b.bookno = Y.bookno
    GROUP BY
        b.bookno
    ORDER BY
        b.millid,
        b.bookno
) d
WHERE
    (d.orderqty - d.dispqty) > 0
ORDER BY
    d.millid,
    d.bookno


text:
Maurkice Pouncey, Ju-Ju Smith-Schuster show support for Antonio Brown from Pro Bowl
ByJEREMY FOWLER via <a href="http://espn.go.com/" title="ESPN" class="espn_sc_byline">ESPN </a>via
ORLANDO, Fla. -- The Pittsburgh Steelers are supporting Antonio Brown from the Pro Bowl.
Center and captain Maurkice Pouncey said he believes the team can work out its issues with Brown, while receiving mate JuJu Smith-Schuster stressed he doesn't want Brown traded.
The Steelers are shopping Brown after the All-Pro receiver did not show up for the Saturday walk-through and cut off contact with the organization.
"We're a band of brothers. We've been together a long time," Pouncey said. "You can't tell me a great phone conversation or a sitdown can't get things right."
Pouncey compared Brown's relationship with quarterback Ben Roethlisberger to brothers who occasionally have a dispute but find ways to make up. Pouncey also disputed the Pittsburgh Post-Gazette report that Brown threw a football at somebody during the Wednesday walk-through of Week 17. "It didn't happen," he said.
Brown became upset and left the walk-through after Roethlisberger wanted to run a hot read again and the team put somebody else in the lineup, a source told ESPN's Adam Schefter, who also reported Roethlisberger and Brown talked afterward and Brown felt underappreciated by some in the organization.
Pouncey believes that time can heal issues and every star player he's been around has had an edge to him, an "it" factor.
"The simple fact it's two Hall of Fame players, there's a reason it's being brought up so much," said Pouncey about Brown and Roethlisberger. "Rightfully so. I agree everyone has opinions and everybody can talk about things.
"But I honestly think, and I've been playing football a long time, things will get worked out. They are the best duo in Steeler history. If you don't want to talk to two Hall of Famers who have played with each other and did so much together, I just don't understand what team is anymore."
Smith-Schuster, who replaced Brown in the Pro Bowl due to injury, said he's reached out to Brown and hasn't heard back but stressed players are vacationing this time of year and contact is minimal. He "no doubt" expects to chat with Brown at some point soon, he said.
Smith-Schuster won the Steelers' Most Valuable Player award, as voted on by teammates, after recording a team-high 111 catches and 1,426 yards.
"He helps out the team a lot -- not only myself, he makes the team better," said Smith-Schuster about why he doesn't want Brown traded. "Obviously I don't control the situation, but if I could, I wouldn't like for that to happen."
Asked about the source of Brown's frustration, Smith-Schuster said he's focused on himself.
Brown has an NFL-record six straight 100-catch seasons and led the league with 15 touchdowns in 2018. During the season, several coaches and players stressed Brown's ability to draw double teams from defenses helps unlock the offense for other playmakers.
But tension seemed to be building throughout the season. Brown had a flare-up on the sideline in a loss to Kansas City in Week 2, and the next day, he tweeted 'trade me let's find out' to a former Steelers employee who floated the notion Brown should thank Roethlisberger for his production. Coach Mike Tomlin acknowledged after the season that there might come a point when Brown's antics outweigh his positives.
Pouncey said issues inside NFL locker rooms boil over when a team loses. The Steelers finished 9-6-1, losing four of their last six games to fall out of the playoffs for the first time since 2013.
"We've got a lot of great players on this team. We should be in the playoffs playing," Pouncey said. "I honestly think we should be still playing right now. For reporters that have been following this team a long time, for the fans who have been following a long time, I get it it's disappointing, trust me. It's disappointing to us. We all want it. Whenever things like that happen, sometimes you can overlook some of the bad things that have happened over the years. When you're winning, everything's great."


If you need parts we are here to help. We carry a multi-million dollar parts inventory and have a trained staff of service technicians ready to get your equipment back up and running. We are on call 24 hours a day, seven days a week.


text:
package aks

import "log"
import "math/big"

// Returns whether (X + a)^n = X^n + a mod (n, X^r - 1). tmp1, tmp2,
// and tmp3 must be bigIntPoly objects constructed with N, R = n, r,
// and they must not alias each other.
func isAKSWitness(n, a big.Int, tmp1, tmp2, tmp3 *bigIntPoly) bool {
	// Left-hand side: (X + a)^n mod (n, X^r - 1).
	tmp1.Set(a, *big.NewInt(1), n)
	tmp1.Pow(n, tmp2, tmp3)

	// Right-hand side: (X^n + a) mod (n, X^r - 1).
	tmp2.Set(a, n, n)

	isWitness := !tmp1.Eq(tmp2)
	return isWitness
}

// Returns the first AKS witness of n with the parameters r and M, or
// nil if there isn't one.
func getFirstAKSWitness(n, r, M *big.Int, logger *log.Logger) *big.Int {
	tmp1 := newBigIntPoly(*n, *r)
	tmp2 := newBigIntPoly(*n, *r)
	tmp3 := newBigIntPoly(*n, *r)

	for a := big.NewInt(1); a.Cmp(M) < 0; a.Add(a, big.NewInt(1)) {
		logger.Printf("Testing %v (M = %v)...\n", a, M)
		isWitness := isAKSWitness(*n, *a, tmp1, tmp2, tmp3)
		if isWitness {
			return a
		}
	}
	return nil
}

// Holds the result of an AKS witness test.
type witnessResult struct {
	a         *big.Int
	isWitness bool
}

// Tests all numbers received on numberCh if they are witnesses of n
// with parameter r. Sends the results to resultCh.
func testAKSWitnesses(
	n, r *big.Int,
	numberCh chan *big.Int,
	resultCh chan witnessResult,
	logger *log.Logger) {
	tmp1 := newBigIntPoly(*n, *r)
	tmp2 := newBigIntPoly(*n, *r)
	tmp3 := newBigIntPoly(*n, *r)

	for a := range numberCh {
		logger.Printf("Testing %v...\n", a)
		isWitness := isAKSWitness(*n, *a, tmp1, tmp2, tmp3)
		logger.Printf("Finished testing %v (isWitness=%t)\n",
			a, isWitness)
		resultCh <- witnessResult{a, isWitness}
	}
}

// Returns an AKS witness of n with the parameters r, start, and end,
// or nil if there isn't one. Tests up to maxOutstanding numbers at
// once.
func GetAKSWitness(
	n, r, start, end *big.Int,
	maxOutstanding int,
	logger *log.Logger) *big.Int {
	numberCh := make(chan *big.Int, maxOutstanding)
	defer close(numberCh)
	resultCh := make(chan witnessResult, maxOutstanding)
	for i := 0; i < maxOutstanding; i++ {
		go testAKSWitnesses(n, r, numberCh, resultCh, logger)
	}

	// Send off all numbers for testing (counted by i), draining
	// any results that come in (counted by j) while we're doing
	// so.
	var i, j big.Int
	i.Set(start)
	j.Set(start)
	logResult := func(result witnessResult) {
		logger.Printf("%v isWitness=%t\n", result.a, result.isWitness)
	}
	for i.Cmp(end) < 0 {
		select {
		case result := <-resultCh:
			j.Add(&j, big.NewInt(1))
			logResult(result)
			if result.isWitness {
				return result.a
			}
		default:
			var a big.Int
			a.Set(&i)
			numberCh <- &a
			i.Add(&i, big.NewInt(1))
		}
	}

	// Drain any remaining results.
	for j.Cmp(end) < 0 {
		result := <-resultCh
		j.Add(&j, big.NewInt(1))
		logResult(result)
		if result.isWitness {
			return result.a
		}
	}

	return nil
}

// Returns an upper bound for r such that o_r(n) > ceil(lg(n))^2 that
// is polylog in n.
func calculateAKSModulusUpperBound(n *big.Int) *big.Int {
	two := big.NewInt(2)
	three := big.NewInt(3)
	five := big.NewInt(5)
	eight := big.NewInt(8)

	// Calculate max(ceil(lg(n))^5, 3).
	ceilLgN := big.NewInt(int64(n.BitLen()))
	rUpperBound := &big.Int{}
	rUpperBound.Exp(ceilLgN, five, nil)
	rUpperBound = max(rUpperBound, three)

	var nMod8 big.Int
	nMod8.Mod(n, eight)
	if (nMod8.Cmp(three) == 0) || (nMod8.Cmp(five) == 0) {
		// Calculate 8*ceil(lg(n))^2.
		var rUpperBound2 big.Int
		rUpperBound2.Exp(ceilLgN, two, nil)
		rUpperBound2.Mul(&rUpperBound2, eight)
		rUpperBound = min(rUpperBound, &rUpperBound2)
	}
	return rUpperBound
}

// Returns the least r such that o_r(n) > ceil(lg(n))^2 >= ceil(lg(n)^2).
func CalculateAKSModulus(n *big.Int) *big.Int {
	one := big.NewInt(1)
	two := big.NewInt(2)

	ceilLgNSq := big.NewInt(int64(n.BitLen()))
	ceilLgNSq.Mul(ceilLgNSq, ceilLgNSq)
	var r big.Int
	r.Add(ceilLgNSq, two)
	rUpperBound := calculateAKSModulusUpperBound(n)
	for ; r.Cmp(rUpperBound) < 0; r.Add(&r, one) {
		var gcd big.Int
		gcd.GCD(nil, nil, n, &r)
		if gcd.Cmp(one) != 0 {
			continue
		}
		o := calculateMultiplicativeOrder(n, &r)
		if o.Cmp(ceilLgNSq) > 0 {
			return &r
		}
	}

	panic("Could not find AKS modulus")
}

// Returns floor(sqrt(Phi(r))) * ceil(lg(n)) + 1 > floor(sqrt(Phi(r))) * lg(n).
func CalculateAKSUpperBound(n, r *big.Int) *big.Int {
	one := big.NewInt(1)
	two := big.NewInt(2)

	M := calculateEulerPhi(r)
	M = floorRoot(M, two)
	M.Mul(M, big.NewInt(int64(n.BitLen())))
	M.Add(M, one)
	return M
}

// Returns the first factor of n less than M.
func GetFirstFactorBelow(n, M *big.Int) *big.Int {
	var factor *big.Int
	var mMinusOne big.Int
	mMinusOne.Sub(M, big.NewInt(1))
	trialDivide(n, func(q, e *big.Int) bool {
		if q.Cmp(M) < 0 && q.Cmp(n) < 0 {
			factor = q
		}
		return false
	}, &mMinusOne)
	return factor
}


text:
Coinbase Recommends Users to Enable Google Authenticator, Ditch Authy
Posted on October 7, 2022 December 8, 2022 by desherit
You'll then be able to log in again normally without the need to use the authentication app or backup codes. If you want a new list of backup codes it's the same process except you'll click Regenerate Recovery Codes instead. To set up MFA by app instead of text message, go to your banking site's security settings and look for the multi-factor or two-factor https://www.beaxy.com/ authentication section. Most sites list the simple SMS code option first, but go past that and look for authenticator app support. One of Twilio Authy's big advantages is encrypted cloud backup. However, it's somewhat concerning that you can add the account to a new phone using "a PIN code sent via a call or an SMS," according to Authy's support pages.
Authy offers flexible pricing plans for your use case, your volume, and your needs.
It's reliable, supports basically everything and is easy to use.
Apart from sending the OTP to your device, Authy also utilizes soft tokens or time-based one-time passwords , which can be generated even when your device is not connected to the data network.
Authy has the best combination of features, security, and support of any two-factor authentication app we tested.
AndOTP is a free and open-source app for generating TOTPs and HOTPs.
While some of these steps vary between services, entering a code from Authy at the end is required almost every time. Simple, user-friendly Google Authenticator may not have a modern UI, but the minimalist style makes it extremely easy to use. Generating TOTP or HOTP codes is quick and easy, making logging in a breeze. Authy takes support a step further than Google Authenticator. One account easily links to multiple devices, making it easy to set up. However, Authy does not currently support Blackberry devices.
Android Police
You'll sign into your No-IP account as normal with your email or username and password. If you are in the same boat and thinking of making a switch, Authenticator can be an excellent app to have installed for two-factor authentication codes. When you enable two-factor authentication with online services, most services give you a token/QR code that you can add/scan to generate codes. Authenticator apps generate time-based, one-time passcodes , which are usually six digits that refresh every 30 seconds. Once you set up MFA, every time you want to log in to a site, you open the app and copy the code into the secured login page. The time limit means that if a malefactor manages to get your one-time passcode, it won't work for them after that 30 seconds.
This will become a mandatory authentication solution in a few weeks from now. Not everyone will be pleased by this decision, but it appears to be the right one. The app also features multiple providers out of the box, like Google Drive and Proton Mail.
Authy plans & pricing
You can remove an account by tapping the account tile to view the full screen of the account you wish to delete. Authy will permanently remove a credential within 48 hours of marking it for deletion. In the 48 hours before it expires, users can undelete or recover this token, after which it is lost forever. Microsoft has now gone one step further, and in their latest release, they have introduced some new security features for iOS and Android. These include the Number Matching and GPS Location Capabilities. With Microsoft Authenticator, you do not need to use a SIM card, and backups are stored in your iCloud account if you use your Microsoft account.
Authy supports encrypted backups for free, allowing you to store your account data in the cloud and sync it across your devices. That way, you can always restore your account, even if you get a new device. If you decide not to backup your data, Authy has a recovery system in place, too. Two-factor apps use one-time passwords as your second factor. After turning on 2FA on your account, you can scan a QR code to tie that account to your app.
Authy vs Microsoft Authenticator: Ease of Account Recovery
When you use an authenticator app, you bolster the password you know with the token, smartphone, or smartwatch that you have. Authy is an application that installs on your selected device and produces a 6-digit code for you to use in Two-Factor Authentication . The best thing about Authy is that it is compatible with many platforms. Whether you are using iOS, Android, Windows, Mac, or even Linux, you can protect your accounts with Authy.
A two-factor authentication app is a similar idea, but instead of a physical card, the second element is your phone. Do you travel constantly and lose access to your accounts? Authy generates secure tokens offline from the safety of your device, this way you can authenticate securely even when in airplane mode. Whether or not this message will fall on deaf ears, remains to be seen. A lot of consumers are lax when it comes to upgrading their account security. Users who log in to their account will be asked to set up the Google Authenticator as well.
Authy vs Google Authenticator: Two-factor authenticator comparison
If you use a lot of Microsoft applications and services, Microsoft Authenticator is a useful tool that supports passwordless logins for Microsoft apps such as Office, OneDrive, and Outlook. Microsoft includes a cloud backup option too, though it's not as clear as Authy about how the encryption on those backups works. Like Authy, the Microsoft Authenticator has colorful icons for each service that makes it easier to skim for the login you're looking for.
How do you use Authy Authenticator?
Open the Authy Chrome app.
Click the Settings icon.
Click the Red + sign for Add Authenticator Account.
Enter the code from your desired account page, and then click Add Account.
Select the desired logo and token length, enter the desired account name, and then click Done.
Zachary has loved writing about Android since he was a teenager and has worked as a freelance writer at Android Police since the beginning of 2020. He specializes in Samsung products covering hardware news, software updates, and deep dives into new features and customizations. While Samsung is Zac's primary specialty, he has plenty of experience with Pixel devices and Android in general. He's often among the first to install the latest Android beta or Developer Preview onto his phone.
Google Street View app will shut down in 2023, Photo Paths will end with it
You don't need to change your platform because you want to use an app or service to protect your accounts. No new Authy apps will be able to be downloaded to new devices moving forward, but all existing Authy apps will continue to work as designed. With Authy, data can be encrypted and decrypted only on devices you know the password for.
Utilisez Twilio Authy Authenticator pour vos identifications – https://t.co/AoeHlQ8NPq
— Android-Zone.fr (@androidzone1) November 30, 2022
IOS and Android are the two operating systems compatible with Google authenticator. FeatureAuthyGoogle AuthenticatorMulti-device platform supportYes. Android and iOSSecurity capabilitiesYesYesWorks offlineYesYesBackups and synchronizationYes.
You're definitely not making the most of your password manager – ZDNet
You're definitely not making the most of your password manager.
Posted: Tue, 06 Dec 2022 13:33:54 GMT [source]
This code, which is time-sensitive, can come to ETH you via SMS, or it can be generated by a two-factor authentication app, such as Authy, on your phone. When you open Authy you see a grid with large icons that makes it easy to find the account you're looking for, copy the security token, and get on with your day. This simple but fully functional app does everything you want in an authenticator. It lets you add online accounts either manually or with a QR code. The backup is encrypted and only accessible from the 2FAS app.
The number of businesses affected due to data breaches has risen over the years.
Are you re-scanning all your QR codes just to add them to your tablet and smartphone?
Whether you are using iOS, Android, Windows, Mac, or even Linux, you can protect your accounts with Authy.
When you log in next time, enter your username and the code the application generates.
Google Authenticator is one exception in this regard, according to the company. It is possible to make Authy behave more securely, though. Users can disable the multi device setting to ensure phone porting becomes a trivial issue. You'll need the device you installed the authentication app on to sign into your No-IP account.
Enter it in the field shown in the screenshot and click verify. If you no longer have access to your device or authentication application you can log in using a Backup Code. Unlike the other apps listed here, Authy requires your phone number when you first set it up. Authy's Help Center offers a workaround, but we'd prefer it just worked more like other authenticator apps. At least there's an Apple Watch app for those who want it. Unlike Authy, 2FAS doesn't need to know your phone number or even require you to create an online account, so it's not susceptible to SIM-swapping fraud.
But codes can be generated offline and without Internet access once scanned and saved to the device. There are also common FAQs and troubleshooting guides for multiple devices. And there is an in-app chatbot available to ask questions and send feedback. Before you decide on the 2FA app, another crucial factor is how reliable the service is. This means you get continued support for the new mobile operating system, tech support, alerts when security is breached, and, of course, the app's reliability. Microsoft Authenticator also has an easy-to-navigate recovery process.
These devices authenticate with a unique hardware token, and they're generally origin-bound, making them safer overall. Authy combines all the elements we want to see in a 2FA app under one roof. It's totally free, automatically syncs across your devices and it works without an internet connection. It's also very easy to use, with widget support on Android and support for the Apple Watch. If you're looking for a 2FA app that does it all, Authy is for you. Google Authenticator is really the baseline here, because nearly all sites that support 2FA support Google's app as well.
How-To Backblaze Cloud Backup Review – Updated 2021 Backing up your data to the cloud via an automated service is critical. You'll then be prompted to select a logo for the authentication. You can simply search for noip to get our logo for the authentication.
Пришло время https://vulkanrussia-777clubs.com/book-of-fate/ попробовать игры интернет-казино
Как получить максимум от Игорного Вулкан Platinum заведения В интернете пять Бонус за первый взнос


When I commit, IDEA 7 runs code analysis that flags a whole bunch of errors that aren't actually errors (e.g. Hibernate table annotations). In addition, code analysis slows down the commit a lot. How can I turn this off when I'm committing to version control (I'm okay with it running while I'm editing code)?


text:
Home / Archive by Category "Chemical Biology and Medicinal Chemistry" (Page 2)
Category: Chemical Biology and Medicinal Chemistry
Skrajna Awarded American Cancer Society Postdoc Fellowship
Aleksandra Skrajna, Ph.D., a postdoctoral researcher at the UNC Eshelman School of Pharmacy and UNC Lineberger Comprehensive Cancer Center, has been awarded a three-year post-doctoral fellowship from the American Cancer Society. The fellowship, worth over $150,000 over three years, supports the training of promising post-doctoral scientists in preparation for independent careers in cancer research. Skrajna works in the lab of Robert McGinty, M.D., Ph.D., an assistant professor at the School and an associate Lineberger member. Skrajna's research is focused on how enzymes bind to our genetic material in cells to ensure that our genes are expressed appropriately. "By understanding how … Continued
Self-Taught UNC AI System Designs Drugs from Scratch
An artificial-intelligence approach created at the University of North Carolina at Chapel Hill can teach itself to design new drug molecules from scratch. ReLeaSE is an algorithm and computer program developed at the UNC Eshelman School of Pharmacy. It comprises two neural networks: a teacher and a student. The teacher knows the syntax and linguistic rules behind the vocabulary of chemical structures for about 1.7 million known biologically active molecules, said K. H. Lee Distinguished Professor Alexander Tropsha, Ph.D., one of the creators of the new AI system. "After learning the molecular alphabet and the rules of the language, the … Continued
Albert Bowers Promoted to Associate Professor
Albert Bowers, Ph.D., a faculty member in the Division of Chemical Biology and Medicinal Chemistry, has been promoted to the rank of associate professor at the UNC Eshelman School of Pharmacy. Bowers is a member of the UNC Lineberger Comprehensive Cancer Center and an affiliate member of the School's Center for Integrative Chemical Biology and Drug Discovery. Bowers' research focuses on harnessing natural product biosynthesis to make next generation therapeutics. Researchers in the Bowers Lab, who go by the Twitter handle @BowersRangers, use insights and chemistries from natural product biosynthesis to facilitate the discovery and development of new natural product-like … Continued
Eshelman Institute Awards $3.5 Million in June 2018 Funding Round
The Eshelman Institute for Innovation on June 1 funded projects proposed by 25 UNC Eshelman School of Pharmacy faculty and staff members totaling more than $3.5 million. The Eshelman Institute was created by a $100 million gift from alumnus, philanthropist and pharmaceutical executive Fred Eshelman, Pharm.D., to the UNC Eshelman School of Pharmacy in December 2014. The institute aims to inspire a culture of innovation where imagination and creative solutions accelerate change in education, research and health care. The Eshelman Institute has awarded more than $20.8 million since 2015. Awards are divided into three funding tiers: tier 1 projects are funded up to $50,000, … Continued
SGC@UNC Researchers Adopt 'Extreme' Open Science, Share Data as It Happens
Researchers in the UNC Eshelman School of Pharmacy are taking part in an experiment in experimentation by making their research publicly available as it happens. Postdoctoral research associates Alfredo Picado, Ph.D., and Carla Alamillo Ferrer, Ph.D., are participants in the Structural Genomics Consortium's Extreme Open Science Initiative, which encourages SGC scientists in labs around the world to publish their notes online. The UNC-Chapel Hill hub of the SGC, run by Tim Willson, Ph.D., conducts open research into new protein kinase inhibitors with the aim of expanding drug discovery and creation. The norm in science is to guard data until publication. … Continued
UNC Releases Huge Database of Molecules to Support Artificial Intelligence Methods in Chemistry
Researchers at the University of North Carolina at Chapel Hill and the University of Florida have publicly released a massive set of data that they used to create an artificial intelligence that drastically cuts the time needed to design new molecules in drug discovery and other areas of chemistry. The high quality database is publicly available to aid other researchers in creating similar tools and contains over 20 million conformations — or structural variations — of more than 57,000 small, drug-like molecules. In 2017 UNC-Chapel Hill and UF scientists created the ANAKIN-ME method, a neural network that can calculate the … Continued
As Hawke Retires, Jarstfer Steps in as Graduate Education Assistant Dean
After serving as the assistant dean for graduate education with distinction since the position was created in 2011, Roy Hawke, Ph.D., is stepping down in conjunction with his decision to retire. Associate Professor Michael Jarstfer, Ph.D., succeeded Hawke as assistant dean effective March 1. "Our graduate students and faculty owe Roy a big debt of gratitude for his selfless and tireless service on their behalf," said Dhiren Thakker, Ph.D., interim dean of the School. "On behalf of the students, faculty and staff of the School, I am happy to welcome Mike to his new role and thank Roy for providing … Continued
Huang, Roth among 2017's Most Highly Cited Researchers
Leaf Huang, Ph.D., and Bryan Roth, M.D., Ph.D., both faculty members at the UNC Eshelman School of Pharmacy, were included in Clarivate Analytics' roster of the most highly cited researchers of 2017. Clarivate Analytics assembled the roster of more than 3,300 highly cited researchers. The researchers included have published a high number of papers that rank in the top 1 percent most cited in 21 fields of science from 2005 to 2015. Huang, the Fred Eshelman Distinguished Professor in the Division of Pharmacoengineering and Molecular Pharmaceutics, is included in the field of pharmacology and toxicology. Huang is a co-principal investigator … Continued
UNC Researchers Create Light-Activated Version of a Ubiquitous Protein Kinase
In a lab at the University of North Carolina at Chapel Hill, a tiny blue light flashes, and a protein switches on in a cell. Light directs the protein to the mitochondria of the targeted cell. Alternatively, by a bit of genetic tweaking, the protein can be directed to the cell membrane or the cytoskeleton of the cell. This selective targeting and activation allows scientists to see exactly what the protein is doing in a single place and time. This technology is possible due to the efforts of a team at the UNC Eshelman School of Pharmacy led by Fred … Continued
UNC Scientists Take a Big Step toward a Better Opioid
For the first time, scientists at the University of North Carolina at Chapel Hill and collaborators solved the crystal structure of the activated kappa opioid receptor bound to a morphine derivative. They then created a new drug-like compound that activates only that receptor, a key step in the development of better pain medications. The research, published in the journal Cell, shows a route toward creating opioids that relieve pain without causing the severe side effects at the heart of the opioid epidemic. Currently, most opioids bind to several opioid receptors on the surface of cells, and this is one of the main reasons … Continued