text:
Study Suggests Chronic Inflammation Triggers Alzheimer's
Posted: Thursday, December 20, 2012 5:19 PM
(Source: PsychCentral) - A team of scientists under the guidance of the University of Bonn and University of Massachusetts have discovered a new signaling pathway in mice associated with the death of brain nerve cells from chronic inflammation.
"Many years before the initial symptoms of Alzheimer's disease occur, so-called plaques, which consist of incorrectly folded beta-amyloid peptides, form in the brain of affected persons," said lead author Dr. Michael T. Heneka. In addition, there are abnormal tau protein deposits in the brain cells of the patients. "As a result of a signal cascade, there is a chronic inflammatory reaction and the progressive loss of nerve cells," said Dr. Eicke Latz.
Go to full story:
http://psychcentral.com
Lane Simonian
Serenoa and I have been trying to determine the role of inflammation in Alzheimer's disease on the thread on TREM2. I think it more or less comes down to this: peroxynitrites contribute to tissue damage and the death of neurons which leads to inflammation and inflammation can lead to the further production of peroxynitrites. Peroxynitrite scavengers will limit tissue damage, neuronal cell death, and inflammation.
http://www.fasebj.org/content/14/5/691.full
One of the best peroxynitrite scavengers is eugnol which is found in various essential oils (clove, bay laurel, rosemary, basil, nutmeg, etc.).
https://docs.google.com/viewer?a=v&q=cache:GXUZvMR-ndEJ:www.mdpi.com/1420-3049/15/12/9252/pdf+anti-oxidant+anti-inflammatory+essential+oils&hl=en&gl=us&pid=bl&srcid=ADGEESgZADz4sd8Ij_JKcN0c7CO6VxaphGP3--_SlkY_VYgKc5Sh_Cy-zwrmDLCunevFY9jXNPmduRlXpZULfTsgo-aOAPvWtkeESypEXfvoT6WxN2Hkf_jwPIAJ7m5y0yr-NueFtGN9&sig=AHIEtbS3hvD9BzImNtA5Ga5aLQTdFk8k4g
http://www.ingentaconnect.com/content/ben/cbc/2006/00000002/00000001/art00005
Posted: Friday, December 21, 2012 12:16 AM
Good. good, good! Scavenge peroxynitrites and you prevent cell death and inflammation in Alzheimer's disease. This article comes very close to making this point.
Int J Mol Sci. 2012;13(9):12113-29. doi: 10.3390/ijms130912113. Epub 2012 Sep 24.
Gelam honey scavenges peroxynitrite during the immune response.
Kassim M, Mansor M, Suhaimi A, Ong G, Yusoff KM.
Department of Anesthesiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia; E-Mails: marzida@gmail.com (M.M.); gracieo@um.edu.my (G.O.).
Monocytes and macrophages are part of the first-line defense against bacterial, fungal, and viral infections during host immune responses; they express high levels of proinflammatory cytokines and cytotoxic molecules, including nitric oxide, reactive oxygen species, and their reaction product peroxynitrite. Peroxynitrite is a short-lived oxidant and a potent inducer of cell death. Honey, in addition to its well-known sweetening properties, is a natural antioxidant that has been used since ancient times in traditional medicine. We examined the ability of Gelam honey, derived from the Gelam tree (Melaleuca spp.), to scavenge peroxynitrite during immune responses mounted in the murine macrophage cell line RAW 264.7 when stimulated with lipopolysaccharide/interferon-γ (LPS/IFN-γ) and in LPS-treated rats. Gelam honey significantly improved the viability of LPS/IFN-γ-treated RAW 264.7 cells and inhibited nitric oxide production-similar to the effects observed with an inhibitor of inducible nitric oxide synthase (1400W).... Thus, honey may attenuate inflammatory responses that lead to cell damage and death, suggesting its therapeutic uses for several inflammatory disorders.
And two that I have cited before:
Cellular/Molecular
Peroxynitrite Mediates Neurotoxicity of Amyloid β-Peptide1–42- and Lipopolysaccharide-Activated Microglia
Zhong Xie1,
Min Wei1,
Todd E. Morgan1,
Paola Fabrizio1,
Derick Han2,
Caleb E. Finch1, * , and
Valter D. Longo1, *
+ Author Affiliations
1 Division of Biogerontology, Andrus Gerontology Center, and Department of Biological Sciences, and
2 Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles, California 90089
The amyloid β-peptide (Aβ) activates microglia and promotes the generation of cytokines and oxygen species, including nitric oxide (NO) and tumor necrosis factor α (TNF-α), which can be either neurotoxic or neuroprotective. We show that neuron death in cocultures of rat cortical microglia and neurons activated by lipopolysaccharide (LPS) or Aβ1–42 plus interferon γ (IFNγ) is caused by short-lived diffusible molecules and follows the generation of superoxide and/or peroxynitrite as determined by electron paramagnetic spectroscopy. Neurotoxicity induced by LPS or Aβ1–42 plus IFNγ is blocked by inhibitors of NO synthesis and by the peroxynitrite (ONOO−) decomposition catalysts FeTMPyP [5,10,15,20-tetrakis(n-methyl-4′-pyridyl)porphinato iron (III) chloride] and FeTPPS [5,10,15,20-tetrakis(4-sulfonatophenyl)prophyrinato iron (III) chloride] but not by the TNF-α inhibitor pentoxifylline. The specificity of FeTMPyP for ONOO− was confirmed by its ability to block the toxicity of a peroxynitrite donor but not of NO donors or of high levels of superoxide in a yeast mutant lacking superoxide dismutase 1. These results implicate peroxynitrite as a mediator of the toxicity of activated microglia, which may play a major role in Aβ1–42 neurotoxicity and Alzheimer's disease.
Behav Brain Res. 2007 Jun 18;180(2):139-45. Epub 2007 Mar 12.
A natural scavenger of peroxynitrites, rosmarinic acid, protects against impairment of memory induced by Abeta(25-35).
Alkam T, Nitta A, Mizoguchi H, Itoh A, Nabeshima T.
Department of Neuropsychopharmacology & Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan.
Peroxynitrite (ONOO(-))-mediated damage is regarded to be responsible for the cognitive dysfunction induced by amyloid beta protein (Abeta) in Alzheimer's disease (AD). In the present study, we examined the protective effects of rosmarinic acid (RA), a natural scavenger of ONOO(-), on the memory impairment in a mouse model induced by acute i.c.v. injection of Abeta(25-35). Mice daily received i.p. several doses of RA after the injection of Abeta(25-35). RA prevented the memory impairments induced by Abeta(25-35) in the Y maze test and novel object recognition task. RA, at the effective lowest dose (0.25mg/kg), prevented Abeta(25-35)-induced nitration of proteins, an indirect indicator of ONOO(-) damage, in the hippocampus. At this dose, RA also prevented nitration of proteins and impairment of recognition memory induced by ONOO(-)-i.c.v.-injection. Co-injection of the non-memory-impairing dose of ONOO(-) with Abeta(25-35) blocked the protective effects of RA (0.25mg/kg). These results demonstrated that the memory protective effects of RA in the neurotoxicity of Abeta(25-35) is due to its scavenging of ONOO(-), and that daily consumption of RA may protect against memory impairments observed in AD.
Find the right peroxynitrite scavenger or scavengers and you not only stop the progression of Alzheimer's disease, you partially reverse it.
Posted: Saturday, December 22, 2012 2:07 PM
Thanks, Lane!!! Ummm, I am great at reading/understanding legalese, but go cross-eyed reading medical terms, but got that peroxynitrites are the problem...right?
That is right, Myriam! The same pathway that leads to the formation of peroxynitrites leads to inflammation. It may be the peroxynitrites themselves by damaging tissue and killing neurons cause most of the inflammation. In any case if you block peroxynitrite formation, you also block inflammation, and more importantly you prevent the death of neurons. That is why eugenol in various essential oils by acting as peroxynitrite scavengers help prevent the death of neurons.
Eugenol (4-allyl-2-methoxyphenol) is a fragrant compound that is commonly contained in various sorts of plants, especially in spices and medicinal herbs. Eugenol has been used for dental analgesic, which also has anticonvulsive and anti-microbial activities. Besides, anti-inflammatory and antioxidative activities of eugenol are known...Eugenol inhibits Aβ-induced excessive influx of calcium ion into neurons that causes neuronal death.
J Agric Food Chem. 2005 Jun 15;53(12):4762-5.
In vitro activity of the essential oil of Cinnamomum zeylanicum and eugenol in peroxynitrite-induced oxidative processes.
Chericoni S, Prieto JM, Iacopini P, Cioni P, Morelli I.
Dipartimento di Chimica Bioorganica e Biofarmacia, Università di Pisa, via Bonanno 33, 56126 Pisa, Italy.
The essential oil obtained from the bark of Cinnamomum zeylanicum Blume (Lauraceae) and three of its main components, eugenol, (E)-cinnamaldehyde, and linalool (representing 82.5% of the total composition), were tested in two in vitro models of peroxynitrite-induced nitration and lipid peroxidation. The essential oil and eugenol showed very powerful activities, decreasing 3-nitrotyrosine formation with IC50 values of 18.4 microg/mL and 46.7 microM, respectively (reference compound, ascorbic acid, 71.3 microg/mL and 405.0 microM) and also inhibiting the peroxynitrite-induced lipid peroxidation showing an IC50 of 2.0 microg/mL and 13.1 microM, respectively, against 59.0 microg/mL (235.5 microM) of the reference compound Trolox. On the contrary, (E)-cinnamaldehyde and linalool were completely inactive.
And from one of the best early studies on peroxynitrites:
Widespread Peroxynitrite-Mediated Damage in Alzheimer's Disease
Mark A. Smith1,
Peggy L. Richey Harris1,
Lawrence M. Sayre2,
Joseph S. Beckman3, and
George Perry1
1 Institute of Pathology and
2 Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, and
3 Department of Anesthesiology, School of Medicine, University of Alabama, Birmingham, Alabama 35233
Increasing evidence suggests that oxidative damage to proteins and other macromolecules is a salient feature of the pathology of Alzheimer's disease. Establishing the source of oxidants is key to understanding what role they play in the pathogenesis of Alzheimer's disease, and one way to examine this issue is to determine which oxidants are involved in damage.
In this study, we examine whether peroxynitrite, a powerful oxidant produced from the reaction of superoxide with nitric oxide, is involved in Alzheimer's disease. Peroxynitrite is a source of hydroxyl radical-like reactivity, and it directly oxidizes proteins and other macromolecules with resultant carbonyl formation from side-chain and peptide-bond cleavage. Although carbonyl formation is a major oxidative modification induced by peroxynitrite, nitration of tyrosine residues is an indicator of peroxynitrite involvement. In brain tissue from cases of Alzheimer's disease, we found increased protein nitration in neurons, including but certainly not restricted to those containing neurofibrillary tangles (NFTs). Conversely, nitrotyrosine was undetectable in the cerebral cortex of age-matched control brains. This distribution is essentially identical to that of free carbonyls.
These findings provide strong evidence that peroxynitrite is involved in oxidative damage of Alzheimer's disease. Moreover, the widespread occurrence of nitrotyrosine in neurons suggests that oxidative damage is not restricted to long-lived polymers such as NFTs, but instead reflects a generalized oxidative stress that is important in disease pathogenesis.
http://www.jneurosci.org/content/17/8/2653.full
And one of the best conclusions in regards to peroxynitrite scavengers in the treatment of Alzheimer's disease.
[Clinical trials with over-the-counter supplements have concentrated either on
items which suppress inflammation, or on antioxidants which scavenge oxygen
derived free radicals. Most of these items have proved to be worthless in the
treatment of Alzheimer's disease. Similarly most drugs used to treat Alzheimer's
disease do little to slow the deterioration, but instead offer a mild temporary
symptom relief. However, evidence has been accumulating that the primary driver
of Alzheimer's disease is a nitrogen derived free radical called peroxynitrite,
which may mediate both amyloid and tau accumulation as well as their toxicity.
Excellent results have been obtained with peroxynitrite scavengers, with
reversals of Alzheimer's disease in human clinical trials being repeatedly
demonstrated. IMHO, the only thing which may be preventing the abolition of
Alzheimer's disease is the mental inertia of scientists, as well as the
bureaucrats who fund them. Unfortunately, most bureaucrats keep throwing money into repeatedly testing discredited interventions, while ignoring successful
ones. Common sense is anything but...]
http://www.cryonet.org/cgi-bin/dsp.cgi?msg=32233
Further evidence that peroxynitrites are the principal cause of and should be the prinicipal target in the treatment of Alzheimer's disease.
Peroxynitrite, the coupling product of superoxides and nitric oxide, is a potent oxidant that induces an array of deleterious events including peroxidation of membrane lipids (Rubbo et al., 1994), depletion of glutathione (Salgo et al., 1995), DNA single strand breakage (Szabó & Ohshima, 1997), mitochondrial dysfunction (Brown, 1999) and cell death (Cookson et al., 1998; Pieper et al., 1999). All these events are thought to be directly mediated by peroxynitrite.
In the present study, we report experimental evidence consistent with the possibility that peroxynitrite may also act as a signalling molecule. In particular, endogenous as well as exogenous peroxynitrite promotes a release of arachidonic acid (AA) most likely attributable to stimulation of phospholipase A2 (PLA2).
In the chart below it is phospholipse C activation that causes the activation of protein kinase C and MAPK which results in the production of peroxynitrites. So now I understand why most anti-inflammatories, such as aspirin and ibuprofen, don't work in the treatment of Alzheimer's disease: they work to control inflammation long after peroxynitrites have already formed. I become more certain of the mantra every day. Stop the formation of peroxynitrites and you prevent Alzheimer's disease. Scavenge and repair the damage done by peroxynitrites, and you not only stop the progression of Alzheimer's disease you partially reverse it. I know fairly specifically which compounds do both, but armed with this knowledge some researcher who was truly interested in treating this disease could likely find even more effective treatments in very short order.
Posted: Friday, December 28, 2012 9:38 PM
My neurologist recommended that I consider trying this diet to help with the plaque in my brain that seems to be the cause of my frontaltemporal dememetia and vascular dementia.
The Anti-Inflammatory diet may help with the dementia it is worth a try. http://www.drweil.com/drw/u/ART02012/anti-inflammatory-diet
Posted: Saturday, December 29, 2012 10:59 AM
A belated welcome, Brutus. I am glad that your neurologist recommended that you consider trying Dr. Weil's anti-inflammatory diet. I contacted Dr. Weil's institute in Arizona but they are not currently doing any research on dementia. Nevertheless this type of diet may help in the treatment of dementia.


text:
//
//  MKAnnotationView+YYWebImage.h
//  YYKit <https://github.com/ibireme/YYKit>
//
//  Created by ibireme on 15/2/23.
//  Copyright (c) 2015 ibireme.
//
//  This source code is licensed under the MIT-style license found in the
//  LICENSE file in the root directory of this source tree.
//

#import <UIKit/UIKit.h>
#import <MapKit/MapKit.h>

#if __has_include(<YYKit/YYKit.h>)
#import <YYKit/YYWebImageManager.h>
#else
#import "YYWebImageManager.h"
#endif

NS_ASSUME_NONNULL_BEGIN

/**
 Web image methods for MKAnnotationView.
 */
@interface MKAnnotationView (YYWebImage)

/**
 Current image URL.

 @discussion Set a new value to this property will cancel the previous request
 operation and create a new request operation to fetch image. Set nil to clear
 the image and image URL.
 */
@property (nullable, nonatomic, strong) NSURL *imageURL;

/**
 Set the view's `image` with a specified URL.

 @param imageURL    The image url (remote or local file path).
 @param placeholder The image to be set initially, until the image request finishes.
 */
- (void)setImageWithURL:(nullable NSURL *)imageURL placeholder:(nullable UIImage *)placeholder;

/**
 Set the view's `image` with a specified URL.

 @param imageURL The image url (remote or local file path).
 @param options  The options to use when request the image.
 */
- (void)setImageWithURL:(nullable NSURL *)imageURL options:(YYWebImageOptions)options;

/**
 Set the view's `image` with a specified URL.

 @param imageURL    The image url (remote or local file path).
 @param placeholder The image to be set initially, until the image request finishes.
 @param options     The options to use when request the image.
 @param completion  The block invoked (on main thread) when image request completed.
 */
- (void)setImageWithURL:(nullable NSURL *)imageURL
               placeholder:(nullable UIImage *)placeholder
                   options:(YYWebImageOptions)options
                completion:(nullable YYWebImageCompletionBlock)completion;

/**
 Set the view's `image` with a specified URL.

 @param imageURL    The image url (remote or local file path).
 @param placeholder The image to be set initially, until the image request finishes.
 @param options     The options to use when request the image.
 @param progress    The block invoked (on main thread) during image request.
 @param transform   The block invoked (on background thread) to do additional image process.
 @param completion  The block invoked (on main thread) when image request completed.
 */
- (void)setImageWithURL:(nullable NSURL *)imageURL
               placeholder:(nullable UIImage *)placeholder
                   options:(YYWebImageOptions)options
                  progress:(nullable YYWebImageProgressBlock)progress
                 transform:(nullable YYWebImageTransformBlock)transform
                completion:(nullable YYWebImageCompletionBlock)completion;

/**
 Set the view's `image` with a specified URL.

 @param imageURL    The image url (remote or local file path).
 @param placeholder he image to be set initially, until the image request finishes.
 @param options     The options to use when request the image.
 @param manager     The manager to create image request operation.
 @param progress    The block invoked (on main thread) during image request.
 @param transform   The block invoked (on background thread) to do additional image process.
 @param completion  The block invoked (on main thread) when image request completed.
 */
- (void)setImageWithURL:(nullable NSURL *)imageURL
               placeholder:(nullable UIImage *)placeholder
                   options:(YYWebImageOptions)options
                   manager:(nullable YYWebImageManager *)manager
                  progress:(nullable YYWebImageProgressBlock)progress
                 transform:(nullable YYWebImageTransformBlock)transform
                completion:(nullable YYWebImageCompletionBlock)completion;

/**
 Cancel the current image request.
 */
- (void)cancelCurrentImageRequest;

@end

NS_ASSUME_NONNULL_END

redpajama_set_name: RedPajamaGithub


text:
The UK will issue a new version of the European Health Insurance Card (EHIC) to individuals entitled to it under the withdrawal agreement.
UK same-sex unions to face hurdles in some EU countries from 2021
Same-sex unions (and divorces) registered in the UK from January 2021 will not be recognised in some EU countries as a result of Brexit.
UK and EU urge holidaymakers to prepare for "inevitable changes" from 2021
Holidaymaking between the UK and EU countries will require more preparation from next year.
Under a proposal by the British government, from January 2021 the UK will no longer reimburse healthcare for pensioners who move to EU countries.
EU Parliament calls for 'attention' for children in post-Brexit divorces
From January 2021, UK-EU families involved in separations will have to deal with more complex and costly legal procedures.
Discovering Europe by bike on the EuroVelo routes
Did you know that there is a network of 16 long distance cycle routes that cross and connect the whole European continent?
Most EU countries to open internal borders by 15 June
After three months of lockdown due to the Covid-19 pandemic, most European countries are preparing to re-open their borders with other EU states.
Stranded abroad: how EU repatriations work and why some EU citizens struggled to return to the UK
Coronavirus travel restrictions have left some 600,000 EU citizens stranded overseas, according to data published by the European Commission.
How to make home schooling with bilingual children more effective
Home schooling is not easy at the best of times, let alone in the midst of a pandemic. And when multiple languages are involved, the task gets even harder.
Do you speak English? The link between language and identity
Why are some people feeling offended by the sound of other languages? Soile Pietikäinen interviews Dr Philip Seargeant from the Open University.
Who is entitled to a UK's European Health Insurance Card (EHIC) after Brexit
The UK has left the EU, but will continue to issue European Health Insurance Cards (EHICs) under the provisions of the withdrawal agreement.
"I lived through 'interesting times', now I want stability" – two stories about moving across borders
Following our survey, we have asked two people who have experienced moving across multiple borders to share their stories, hopes and doubts about Brexit.

redpajama_set_name: RedPajamaCommonCrawl


text:
Q: Blazor 0.6.0 "wipes" Flurl-compatibility? After updating Blazor from 0.5.1 (with working Flurl) to 0.6.0, calls via flurl throw an exception:
WASM: [Flurl.Http.FlurlHttpException] Call failed. Cannot invoke method
because it was wiped. See stack trace for details.

The project creates a HttpClientFactory which gets Blazor's HttpClient for being used by Flurl:
Create FlurlClient with Blazor's HttpClient (http) using HttpClientFactoryForBlazor:
IFlurlClient c = new FlurlClient() { Settings = new Flurl.Http.Configuration.ClientFlurlHttpSettings { HttpClientFactory = new HttpClientFactoryForBlazor(http) }};

Use the FlurlClient (c) for example by via Flurl's extensionmethod "IFlurlRequest.WithClient(c);"
private class HttpClientFactoryForBlazor : Flurl.Http.Configuration.IHttpClientFactory
{
    private readonly HttpClient httpClient;

    public HttpClientFactoryForBlazor(HttpClient httpClient)
    {
        this.httpClient = httpClient;
    }

    public virtual HttpClient CreateHttpClient(HttpMessageHandler handler)
    {
        return this.httpClient;
    }
}

So, it seems like this approach does no longer work.
Does anybody know how to make Flurl with Blazor 0.6.0 work?
Call-Stack is:
WASM: [Flurl.Http.FlurlHttpException] Call failed. Cannot invoke method because it was wiped. See stack trace for details. GET http://srv01.servicegrid.eu:4455/API/Status?forceLoadDbs=False blazor.webassembly.js:1:32098
WASM:   at Flurl.Http.FlurlRequest.HandleExceptionAsync (Flurl.Http.HttpCall call, System.Exception ex, System.Threading.CancellationToken token) <0x26945b8 + 0x001c2> in <c38761af4558433f81b1691eb86a1548>:0 blazor.webassembly.js:1:32098
WASM:   at Flurl.Http.FlurlRequest.SendAsync (System.Net.Http.HttpMethod verb, System.Net.Http.HttpContent content, System.Threading.CancellationToken cancellationToken, System.Net.Http.HttpCompletionOption completionOption) <0x2665d30 + 0x005e6> in <c38761af4558433f81b1691eb86a1548>:0 blazor.webassembly.js:1:32098
WASM:   at Flurl.Http.FlurlRequest.SendAsync (System.Net.Http.HttpMethod verb, System.Net.Http.HttpContent content, System.Threading.CancellationToken cancellationToken, System.Net.Http.HttpCompletionOption completionOption) <0x2665d30 + 0x0079a> in <c38761af4558433f81b1691eb86a1548>:0 blazor.webassembly.js:1:32098
WASM:   at Flurl.Http.HttpResponseMessageExtensions.ReceiveJson[T] (System.Threading.Tasks.Task`1[TResult] response) <0x26a2180 + 0x000d6> in <c38761af4558433f81b1691eb86a1548>:0 blazor.webassembly.js:1:32098
WASM:   at DotNetFabrik.FlurlExtensions.FlurlRequestExtensions.HandleWebApiExceptions[T] (System.Threading.Tasks.Task`1[TResult] task) <0x26a43f8 + 0x000e2> in <8c1e6df9d3f545cd831ff49915df2d85>:0 blazor.webassembly.js:1:32098
WASM:   at DotNetFabrik.FlurlExtensions.FlurlRequestExtensions.HandleWebApiExceptions[T] (System.Threading.Tasks.Task`1[TResult] task) <0x26a43f8 + 0x00264> in <8c1e6df9d3f545cd831ff49915df2d85>:0 blazor.webassembly.js:1:32098
WASM:   at BlazorCoreDMSTools.CommunicationService.CommunicationService.SetTokenAsync (System.String token, System.String database, System.String serverUri) <0x260dc60 + 0x00d9e> in <cb925648b50340888772566fbaeac465>:0

A: Just for some background, the Blazor team is in the process of significantly reducing the app's footprint, and resorting to some unusual measures to do so. In a nutshell, they've reduced it by about 20% by "wiping" HttpClientHandler.

wipe means "replace specified method bodies with a single throw
  instruction". Doing this (instead of actually removing the method
  entirely) means that the assembly retains a completely standard API
  surface, and if you try to use one of the wiped methods, you get an
  easy-to-understand exception stack trace that tells you which wiped
  method you're trying to call.

This is what you've bumped up against: Blazor is still aware of HttpClientHandler for compilation purposes, but will throw a runtime exception if you (or in this case a compatible library) try to use it.
But HttpClient must wrap some implementation of HttpMessageHandler Blazor has its own: BrowserHttpMessageHandler. And Flurl provides an easy way to swap this in via its HttpClientFactory. But you don't need to pass in an HttpClient instance or implement CreateHttpClient. Instead, inherit from DefaultHttpClientFactory and just override CreateMessageHandler:
private class HttpClientFactoryForBlazor : DefaultHttpClientFactory
{
    public override HttpMessageHandler CreateMessageHandler()
    {
        return new BrowserHttpMessageHandler();
    }
}

I'd also recommend registering this once globally on app startup, rather than every time you create a FlurlClient:
FlurlHttp.Configure(settings =>
{
    settings.HttpClientFactory = new HttpClientFactoryForBlazor();
});

It should also be noted that Blazor is still experimental and that BrowserHttpMessageHandler may be deprecated in a future release, so expect that this could be just a temporary work-around.

A: Currently in my 3.0 preview 5, BrowserHttpMessageHandler is not there anymore. Here is my current fix by simply not using any HttpMessageHandler. As far as I am aware, no problem happens to me yet, but I am not sure in all use cases:
class BlazorHttpClientFactory : DefaultHttpClientFactory
{

    public override HttpClient CreateHttpClient(HttpMessageHandler handler)
    {
        return new HttpClient();
    }

    public override HttpMessageHandler CreateMessageHandler()
    {
        return null;
    }

}

redpajama_set_name: RedPajamaStackExchange


Published 04/22/2019 08:18:03 pm at 04/22/2019 08:18:03 pm in How To Make Bottle.
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text:
Singapore's national flag
In 1959, a new state flag was created to represent Singapore shortly after it became a self-governing state under British rule. Developed by a committee led by then Deputy Prime Minister Toh Chin Chye, the flag was unveiled on 3 December 1959, the day when Singapore's ...
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Singapore's lion's head symbol was launched in 1986 as an alternative national symbol. The logo is in solid red against a white background – the colours of the national flag. The lion symbolises courage, strength and excellence, while the five partings of the lion's ...
National coat of arms (State crest)
The national coat of arms, also known as the state crest, symbolises Singapore as a self-governing and independent state. Like the national flag, the state crest was designed by a committee headed by then Deputy Prime Minister Toh Chin Chye. Singapore's state crest ...
The Shared Values are five national values of Singapore. They were formalised by the government on 15 January 1991 to forge a national identity in the face of a changing society with evolving values. The Shared Values were formulated according to the nation's multicultural ...
Singapore's national anthem
The Singapore national anthem, Majulah Singapura, was composed in 1958 by Zubir Said, a prolific songwriter, as the official song of the City Council of Singapore. After Singapore became a self-governing state under British rule on 3 June 1959, the song was shortened ...
National Pledge
The finalised version of the national pledge was largely drafted by then Minister for Foreign Affairs S. Rajaratnam in February 1966 as a way to promote national loyalty and consciousness among citizens following Singapore's separation from Malaysia on 9 August ...
The Merlion is a mythical creature with the head of a lion and the body of a fish. Regarded as a Singapore icon, the Merlion was designed in 1964 for the Singapore Tourist Promotion Board (STPB; now known as the Singapore Tourism Board) and functioned as its logo ...
Vanda Miss Joaquim
Papilionanthe Miss Joaquim, commonly referred to as Vanda Miss Joaquim, is the first recorded orchid hybrid from Singapore, created in the early 1890s. On 15 April 1981, the Agnes variety of the Vanda Miss Joaquim was launched as Singapore's national flower. The ...
Agnes Joaquim
Agnes Joaquim (Ashkhen Hovakimian) (b. 7 April 1854, Singapore–d. 2 July 1899, Singapore), a second-generation Singapore resident of Persian Armenian descent, is best known for successfully cross-breeding Vanda teres with Vanda hookeriana to create a new orchid ...


This model Red-Dot Sight features a 5 MOA Dot Red/Green reticle. For unmatched versatility this reticle can be illuminated in green or red at various brightness settings. The 11-position rheostat controls the brightness to perfectly match any lighting condition. The Dual Color Red-Dot Sight includes an integral saddle mount for Remington 12 Ga. shotguns.
This model sight is machined from a one-piece extrusion. Lightweight and easy to mount the Dual Color Red-Dot Sight features an unlimited eye relief a wide field of vision and multi-coated lenses that produce 95% light transmittance. A special anti-reflective interior eliminates stray light from appearing inside the sight. The TruGlo Red-Dot Sight is waterproof and fog-proof. It is great in most any environment and performs well even in inclement weather. The Dual Color 1 x 30 Red-Dot Sight includes see-thru /flip-up lens caps and runs on a 3V-CR2032 battery (included).


Proposals to change the H-1B visa program, which allows companies to hire specialized foreign workers in the U.S. on a temporary basis, have been debated by lawmakers from both sides of the aisle for years. The visas are most heavily used by foreign companies providing temporary computer services, especially Indian companies such as Tata, Wipro and Infosys, but also by high-tech companies such as Amazon, Microsoft and Google. Critics contend that the program does not attract the "best and brightest" foreign workers, that it pays lower wages, and that it is used to facilitate the offshoring of services (by allowing non-U.S. workers to be trained at the offshoring company, and to be based at the offshoring company as a liaison with the company providing the services). While the Trump Administration has not made any official announcements regarding the H-1B visas, its emphasis on reforming the U.S. immigration system might give new steam to H-1B reforms. Four bills that address H-1B visas have been introduced in the House and Senate since January.
Critics contend that the program does not attract the "best and brightest" foreign workers, that it pays lower wages, and that it is used to facilitate offshoring of services.
The H-1B visa program allows companies to employ in the U.S. temporary workers who have a bachelor's degree or equivalent, if they work in a "specialty occupation" requiring "theoretical or practical application of a body of highly specialized knowledge" --or are fashion models. Currently, 65,000 such visas are available each year without further restriction, and these are allocated by lottery if the cap is reached. Another 20,000 visas may be awarded to workers with a master's or doctoral degree from a U.S. university, and an unlimited additional number may be awarded to non-profit organizations including universities. In fiscal year 2014, 124,326 petitions of new H-1B employment were approved, and 191,619 petitions for continuing employment (renewals) were approved. The majority, 65 percent, were issued for work in computer-related occupations.
The H-1B visa is not intended for the "best and brightest" workers: that is the purpose of the O-1 temporary visa. The 1990 Immigration Act split the precursor to the H-1B visa, the H-1, into visas for workers of exceptional ability or achievement (O-1) and visas for specialty occupation workers and fashion models (H-1B). The number of O-1 visas is uncapped, but applications are burdensome (for both applicants and adjudicators) and adjudicators have considerable latitude for discretion. 11,406 workers received new O-1 visas in FY 2015.
Rather than constituting an abuse, the use of the H-1B for offshoring is something the United States has committed to under the General Agreement on Trade in Services (GATS) of 1995. In this World Trade Organization (WTO) agreement aimed at facilitating trade in services, the United States committed to making 65,000 H-1B visas available for temporary foreign workers providing services. The United States also committed to allowing companies to transfer certain employees from abroad to the U.S. The WTO notes: "The supply of many services is possible only through the simultaneous physical presence of both producer and consumer. There are thus many instances in which, in order to be commercially meaningful, trade commitments must extend to cross-border movements of the consumer, the establishment of a commercial presence within a market, or the temporary movement of the service provider himself." Because of these commitments, changes to the H-1B visa program can lead to international challenges. The World Trade Organization is currently adjudicating a complaint by India that U.S. H-1B practices such as fee increases violate the GATS.
The system of H-1B prevailing wages provides an incentive for employers to hire inexperienced, and therefore less skilled, workers. H-1B workers must be paid the maximum of the "prevailing wage" and the wage paid by the employer to workers with similar skills and qualifications. The program's "prevailing wage" varies by education (bachelor's degree versus master's degree) and years of experience, increasing sharply at low experience levels to reach a maximum at five years of experience. In contrast, average actual salaries rise gradually with experience over about fifteen years. The difference in how actual and "prevailing" wages progress over time makes it more likely that companies will hire H-1B workers that have lower levels of experience.
It would be legally difficult to reorient the H-1B program away from the provision of computer services and towards attracting the best and brightest immigrants, and may not be desirable. Concerns about insufficient immigrant workers considered among the "best and brightest" would be best addressed by an expansion of the O-1A visa. The language of the legislation is very general, and changes could be made through the rule-making process to expand the number of visas awarded. Substantive changes to the H-1B visa program could constitute violations of U.S. obligations under the General Agreement on Trade in Services (GATS). Changes aimed at reducing the number of H-1B visas awarded to computer and information technology service companies, including the prioritization of applications for workers with the highest salaries or education, would likely trigger a complaint against the U.S. at the World Trade Organization (WTO). A successful complaint would permit retaliation against the United States in the form of tariffs. However, one way to raise the skills of workers for whom H-1B petitions are filed would be to restructure the prevailing wage schedule. The rule-making process should be used to base the prevailing wage schedule on data relating salaries and experience, which is not currently the case.


Processing SSAS Databases Using PowerShell - bzzzt!
Late night maintenance on databases also means I get to write a blog post during the downtime. Tonight's blog post is more PowerShell/SSAS: following on from calculating the size of dimensions and Finding Unprocessed Objects, here's a PowerShell script that will process all the databases on a given instance that match the current process state you input: If you've deployed all the databases to an instance, entering Unprocessed for $CurrentProcessState and ProcessFull for $TypeOfProcess will process all the objects. This is great for overnight batching of processing. I've also used this script to apply changes and then run a ProcessDefault on a database that is PartiallyProcessed and it seems to have worked well.
Once you have saved this to a .ps1 file you open up a PowerShell console and drag and drop the file there (or copy as path, whichever way you like) and press enter. It'll ask you for the ssasInstance, the CurrentProcessType of your database and which Processing option you want, hit enter and off it goes.


Tirren Staaf (born 1977), otherwise known as Pegz (or MC Pegasus), is an Australian hip hop artist and producer hailing from Melbourne, Victoria. He is the CEO of Obese Records. The record label responsible for artists such as Hilltop Hoods, Downsyde, and Bias B. Pegz musical career is long and impressive and his impact as an artist is no less impressive than his business achievements. Pegz earliest music influences were his mom's Stevie Wonder records and Polynesian parties with his father. This soulful influence can be heard on his various tracks throughout his releases.


text:
Be courageous, enthusiastic witnesses of Jesus: Archbishop Filipe Neri Ferrao
Javadekar pitches for private participation in 52nd IFFI edition
Panaji: 'If government respects people's sentiments, cancel Mollem projects' - Congress
This year's edition of IFFI is special: Javadekar
Move over Maharashtra, Maratha politics is Goa's flavour of the season
Amid protests, CM announces relocation of IIT-Goa campus
Panaji: Konkani Cinema - A Long Way to Go
Sat, Apr 25 2009 06:06:41 PM
by Tomazinho Cardozo
April 24, 1950 is a date to be remembered because 59 years back, on this day, the first-ever full-fledged Konkani film entitled "Mogacho Anvddo" was released at the Dasharata Cinema in Mapusa. Konkani language and culture for the first time entered the film world, thanks to the pioneering efforts of A L Jerry Braganza, a cinema enthusiast from Mapusa. Braganza did not only produce the film but also acted the male lead role in the film. He is known as Father of Konkani Cinema but rarely remembered for his great contribution to the Konkani silver screen. The Goa government or any other institution working in the field of Konkani never thought of remembering this great personality for all these years. It was only in 2005, after the completion of 55 long years that Dalgado Konkanni Akademi, for the first time, organized a function on April 24 to commemorate the screening of the first Konkani film "Mogacho Anvddo" and to pay homage to the memory of the late A L Jerry Braganza.
During the last 59 years about 40 full length films and over 150 video films were produced in Goa, Maharaxttra and Karnataka. Some of the important films are 'Mogacho Anvddo', 'Sukhachem Sopon', 'Amchem Noxib', 'Nirmonn', 'Mhoji Ghorkarn', 'Kortubancho Sonvsar', 'Jivit Amchem Oxem', 'Mog ani Moipas', 'Bhuierantlo Monis', 'Suzanne', 'Bhogsonne' etc. In the recent past 'Alisha', 'Sood', 'Padri' and 'Antarnad' have entertained the film lovers of Goa and elsewhere. Very few films have become commercially successful. It is because, although all Goans speak Konkani, very few of them make a point to see a Konkani film. I think it is high time that Goans patronize Konkani films so that they (films) become financially viable, otherwise a time may come when no producer will be willing to take the risk of making a Konkani film. Under these circumstances we will lose Konkani films forever and with it a powerful medium of preserving and promoting our culture.
The government of Goa organized the first-ever Konkani Film Festival in 1997. This was the first step on the part of the government to promote Konkani films. Most of the films that participated were video films because of the cost factor of production. From 1997 to 2005, in all three Konkani Film Festivals were organized and awards presented. The Goa government also announced "The Goa Scheme of Financial Assistance for Films". This scheme provides financial assistance for the production of feature films in Konkani and Marathi and non-feature films including tele-films, short films, and documentaries in Konkani, Marathi, English and Hindi. This scheme envisages grant of financial assistance upto 50% of the cost of production as per the provisions made in the scheme. This scheme which was formulated by the Department of Information & Publicity has been now transferred to the Entertainment Society of Goa (ESG) which deals with all film-related activities in the state. The ESG is in the process of reviewing the said scheme in order to make it more attractive and more beneficial to the producers of Konkani films.
The success of this scheme will depend on both, i.e. the government as well as the producers. The budget provision made by the government for this scheme is of utmost importance. The success of this scheme will depend on the financial support from the government. Secondly the success of this scheme is equally dependent on the producers. Their sincerity and dedication in making films of a high standard is the base of the success. Without being sincere and dedicated to the cause of the development of Konkani cinema, no success can be achieved at any point of time. The unity among the film producers of Goa is also of utmost importance. In a tiny state of Goa, having more than one Association of film producers, is a negative approach towards development of Goan film. Therefore, on this 'Konkani Cinema Day' let us resolve to work in unity in order to produce good quality Konkani films and contribute towards the preservation and promotion of Goan culture.
Ruma Ramani, Margao-Goa
Mon, Mar 14 2011
Do anybody has a cd,dvd or video casette of the movie " jivit amchem oxem".need it desperately.please let me know.
DisAgree Agree [2] Reply Report Abuse
donald, bangalore
Sun, Apr 26 2009
All Goans,Mangaloreans, Konkani speaking people of Ratnagiri upto Cochin should come together to promote Mother konkani cause and promote cultural get togethers and come to an understanding to create more oppertunities for our youth to take over. JAI HO KONKANI !
Melwin D souza/Q8, Melwin / Milar
Amchi Konkani filma It is great and our Konkani songs aer always good.
DisAgree Agree Reply Report Abuse
vimithpeter/shirva \pilar, vimithlpeter ST.MARYS COTTAGE.
Sat, Apr 25 2009
EVERYTHING IS GOLD IF IT IS COUNT AS OLDIES. KEEP IT UP ALL YOUR CHARM.
socorro, Mumbai
long live konkani films.
Charles D''Cunha, Borivli
PADRI- movie a combination of Goan and Mangalorean artists was a hit and well appreciated by all Konkani loving people. Hope many more movies will follow of this calibre.
DisAgree [1] Agree Reply Report Abuse
Lloyd Dsouza, Dubai
Konkani film its good to watch, and best of is konkani songs its always rocking............. every mloreans like it all over the world. Long live Konkani Movies
Jemilson Monteiro, GOA / Saudi Arabia
well written article by Tomazin.we all know the evergreen konkani songs from some of the old films like amchem noxib, nirmon. songs like claudia, mogan asunk borem, godacho panv are etched firmly in the memory. however for the new films to be financially viable requires our support and encouragement.May our mai bhas not only survive but thrive in every way.
Prem, Mangalore
Long live konkani movies....Even today we can hear famous song from Amche nashib..(mogan asun boren) and Mog ani maipas movie..(mog tuzo kithlo ashelo)...
Shankar Bhat, Puttur
In 1980, a Konkani film "JANA MANA" was produced and directed by Dr.Ramesh Kamath, CEO of NETINDIA, Bangalore. Mangalore people were in the lead roles.. It was a hit film.
Great.. In 1980, a Konkani film was produced and directed by Dr.Ramesh Kamath of NETINDIA, Bangalore. It was a hit film..
Title : Panaji: Konkani Cinema - A Long Way to Go
Covid-19 altered cultural, entertainment scenario of Goa: Amit Satija, IAS.
426 Health care workers beneficiaries of Covidshield vaccine.
Be courageous, enthusiastic witnesses of Jesus: Archbishop Filipe Neri Ferrao.
Javadekar pitches for private participation in 52nd IFFI edition.
Don't crowd vaccination rooms, offer inoculated person flower: Javadekar.
Panaji: 'If government respects people's sentiments, cancel Mollem projects' - Congress.
This year's edition of IFFI is special: Javadekar.
Move over Maharashtra, Maratha politics is Goa's flavour of the season.
Amid protests, CM announces relocation of IIT-Goa campus.
Panaji: GMC reports Shripad's health improving.


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Just a quick report from tonights fun over at Ferngully Stamps Craft weekend.....these two lovely ladies both won some Fiskars goodness in the door prize giveaways tonight... Julie and Tracy Anne were newbies tonight who were having lunch across the road at Zagame's and saw the sign....so they booked in for a fun night out...they loved it!
It was lovely meeting you ladies.....and nice to be able to introduce you both to the FISKARS PUNCHES!
ok...better get to bed as I have an early start tomorrow.....we have 2 Sessions fully booked tomorrow....but there are still a few spots for Sunday if you wish to come and have some fun!
......that there are two HUGE Papercrafting Events happening in and around Melbourne this weekend!
and over in the Eastern Suburb or BORONIA.........................Ferngully Stamps (LSS)have their fabulous Demo Dayz Craft Weekend....starting 6pm tonight!! I'm both excited and a little sad....excited to be involved once more with Kerry and Maurie,Marlene and the TEAM at Ferngully Stamps.....offering a fun FISKARS Punches Workshop....but a little sad that I'll miss working with the fabulous PAPERIFIC TEAM!!
We had a change of plans late yesterday with an SOS to have SAM (grandson)over night and today....so whilst he sleeps I'm loading the car......LOL!! Both my boys are asleep....yes....Rod is rocking the house with his snoring....LOL! Sam woke us up around 6:45am. this morning with his little chatter......I don't get him up straight away though.....7am is more reasonable.....LOL!
.........so hubby has gone down for a nap at the same time...he,he.
Hope you all manage to get a little crafty this weekend!! I'll be sure to share some fun pics on here over the weekend!
I popped by my LSS (FernGully Stamps )yesterday to finalise a few things for my Workshop this weekend and spotted Marlene trimming her cardstock with the Fiskars Trimmer so just had to take a quick pic with my Point and Shoot camera......thanks Marls!!!
With over 250 people expected for the Demo Dayz fun craft weekend the Fiskars Trimmers sure make cutting out multiples much quicker.....I'll be doing the same thing with my trimmer today.....and also giving my Scoring blade a good workout!!
OMG......you should see the fabulous range of FISKARS TOOLS now in-store....including trimmers,eyelets setters,scissors.....punches galore.....we are going to be having sooooooooooo much fun Punching up a storm in my Fiskars Workshop!!
I believe spots are filling up very quickly in fact if you intend coming and haven't booked in then make sure you ring the store asap............see number below!!! It's going to be such a fun weekend!!!
I'm packing my trolley later today once I finish work at the WATERGARDEN....it's the last day for the Season...................yeh!!!!
I'm looking forward to working again at FernGully Stamps Demo Dayz coming up on April 1-3rd.
I'll be there demoing Fiskars Tools and offering a fun Make'n'take Workshop using the fabulous FISKARS PUNCHES and Trimmers!!
Also attending shall be Leone Em....lovely lady! Leone is retiring shortly so she is providing some goodies to give away on the weekend.....and she shall be writing some books in the future!
.....this is such a fabulous weekend of crafting fun...sharing of ideas and techniques,specials, door prizes,goody bags.....and so much more!!
The cost is only $15.00 for 3 and a half hours of fun!! Each participant shall complete 5 different projects,be given a goody bag on leaving and be in the draw for some fabulous door prizes......thanks to my good friends at FISKARS for providing some fabulous Door Prizes!!
There are 5 Sessions running over the weekend....one on Friday April 1st commencing at 6pm....then 2 on Saturday April 2nd and 2 on Sunday April 3rd !!
I was visiting one of my Local Craft Stores (Creative Dreams in Boronia) today and was amazed at the amount of FISKARS CRAFT TOOLS that they now have on their shelves.....including the latest Border Punches,Everywhere Punches ,Limited Edition Squeeze Punches and even the hard to find "Oval "n" Oval Again Squeeze Punches.
Some of the tools are on Special eg....Rotary Trimmers for $29.99....great prices!!
I took some pics to share with you all......and put them in this slide show.....I love going in to this store....they also have a HUGE Range of Kaisercraft products,Fynmark Products,heaps of Beading,Cardmaking Supplies,Scrapbooking Supplies.....you name it....they have it!
So if you are after a particular Fiskars Tool....then contact this store.....they are in Dorset Road Boronia,Victoria.......you won't be sorry!
If anyone else spots some Fiskars Specials when they are out and about...let us know and we'll share on here.
I am still on such a HIGH after a fabulous craft weekend......demoing "Punching Techniques" and teaching around 300 partipants at Fern Gully Stamps Craft Store in Boronia how to have fun with punches......get creative.....and create a fun and personal Christmas card.
We also gave the Fiskars Border Punches a work out ....I used "Sunburst" on my sample above......but some participants chose other designs....from what I had provided on the tables......many using these for the first time....we had some men join as well as some teenagers.....which was lovely to see.....there were also families crafting together......the Embossing Border Punches were also on the tables for participants to try...they proved popular.
here are a few more pics from the Weekend FUN!!
ON Sunday....the major door prize winner was drawn by Maurie.....one very excited lady I might add!
Lorraine was lucky enough to win a fabulous Fiskars Stamp Factory which Rod and I had donated.....she had only dropped by the store on Saturday morning to purchase a few supplies and saw us all having such a fun time....that she was able to book in for Sunday afternoon.....so she came back and had the best time.......as did we all.
I love how Maurie and Kerry organise this weekend...they hold these twice a year....and they have 5 workshops stations going at any one time....participants only pay $15 to attend which includes 5 demo workshops where different product/tools are demoed and introduced,afternoon or morning tea.....and 3 and a half hours of pure fun crafting! Crafters then have time to do some serious retail therapy.....it's so well run and I am privileged to have been working in this store the past 3 years....both for FISKARS and for Maurie and Kerry.
I also learnt many techniques over the weekend......including the CD trick in the microwave.....love it!
We even had some Spotlight and Officeworks staff attend...and they also loved it! One came from Fountain Gate and the other from Ferntree Gully.
If you wish to attend the next one early next year......then feel free to contact the store.....or ask to be put on their mailing list so you don't miss out. It really is a fabulous weekend....I can gaurantee a great fun time! Thanks again to Maurie,Kerry, Cassy,Marlene,Jacqui and Jodie.
WOW....what a fun time I have been having over at a favourite Craft Store in Boronia......FERNGULLY STAMPS.......I'm heading back over there for another day of crafting fun,laughter,demos,projects,yummy food,shopping....what more could a girl want.....LOL!
It was nice to see many new people this time trying out tools for the first time...didn't take too long and they were addicted.....LOL!
ok....need to get to bed for an early start tomorrow...shall try and take some more pics......I'd also like to thank store owners Maurie and Kerry for taking me out for dinner tonight.....great food,great company....great fun! What a fun staff to work with......absolutely love it!
These punches are only available through Wholesalers (SSS and Stamp -It)..So ask at your Local Store to see if they have them in yet....if not...tell them you would like them to get them in....they really are a MUST HAVE TOOL! I'm loving mine!
I have been having fun playing around with this Punching System......creating some fun cards lately..
...firstly I created this fun window birthday card for my DIL...Sally for her birthday which was yesterday......I don't normally use much red cardstock but I did this time as it's Sally's favourite colour.
So whilst I had the red out..... I thought I'd have a go at creating a Christmas Window Card...again using the Square Cartridge.......I added some acetate under the windows and punched out some more Kaisercraft Chrsitmas Stamped images using my Fiskars 1" Circle Squeeze Punch and then punched out one red scalloped heart.....alos using my Fiskars My Funny Valentine Squeeze Punch.
I just love how easy this is to use.....you do need to get the Started Set and then you can also purchase other Cartridges...eg. Square..that just fit into the starter set base....so interchangeable.......gotta' love that..........these also come in a Scallop Square and Scallop Circle.
This Everywhere Punch Window System means that you can punch windows anywhere on your card or layout project.......so you can just move it around to suit.....and the base is magnetised so that the top and bottom stay in place once you have lined up where you wish to punch....there are also grid lines on the Placement Piece......think you might like one of these little beauties....??
I shall be taking my Fiskars Everywhere Punch Window System to FernGully Stamps Demo Dayz Craft Weekeend next weekend in Boronia for partipants to try.......in fact Maurie is trying to get some in as he just fell in love with my one this week when I visited......so I actually left it with he and Kerry......they loved it!.....it's actually on loan to them this week....shall be picking it up Thursday.......LOL! That's how much they loved it....they just wanted to be able to play with it......just like I did.......LOL!
Can't wait to work for FernGully Stamps again....they run the best Craft Weekend with over 300 partipants attending over 5 Workshop Sessions on the weekend.Door prizes,giveaways,show bags,workhops,access to new products....and it's a whole lot of fun.
Alison Ellis is also involved next weekend ....we sure are going to have a fun time crafting ALL WEEKEND!! I'll share a few sneak peeks later in the week...you can book with the store...but be quick as Friday Night is already booked out....only a few spots left for Saturday Workshops...and a few left for Sunday.........it's going to be a Whole Lot Of Fun!!
I always take my Fiskars Punches with me when we come to Paynesville in East Gippsland and they were starting to feel neglected I'm sure the past 2 weeks......LOL! But at least I now have some fun Gift Cards all ready to go on Christmas pressies this year......nice to get them done. Does anyone else use craft as a way to relax and unwind?
I was recently sent this 2 and a half inch Circle Lever Punch to play with...OMG....it's perfect for creating Christmas Baubles.......fun Place Cards,etc.etc.


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Late summer offers anglers an array of fishing options to choose from. Fish Coho on the fly, target Halibut, Lingcod and Rockfish in the offshore waters, drift the river for Trout and Coho or travel out to the BlueWater in search of Albacore Tuna. It's all part of the program this fall with Tofino Fish Guides!
Watch the new #yourtofino video we recently collaborated on with Tourism Tofino.
Coho on the fly or on gear, for that matter, provide anglers with a scrappy acrobatic fight and are fantastic table fare. This time of year Coho are abundant in the beautiful waters of Clayoqout Sound. Spectacular scenery and a multitude of sea life is sure to thrill whether your a seasoned angler or out fishing for the first time.
Hooking up these bottom dwellers is a blast, going home with a load of fresh halibut isn't so bad either! Halibut can be fished on a half day charter or incorporated into a full day. In order to access the best Lingcod and Rockfish zones a full day charter is necessary. Blending bottom fishing with a touch of Coho action is a great way to spend a September day!
The river is in prime condition during September and is a fantastic place to spend a day drifting in search of Cutthroat Trout and Coho Salmon. Float down the river in one of our brand new NRS inflatable river kayaks. These safe, stable kayaks are getting rave reviews. Our river raft is another great way to drift the river. Join Lochie MacKenzie a long time fly fishing instructor and a former guide at the prestigious Silver Hilton Steelhead Lodge to learn to cast, or polish up your stroke. Lochie specializes in Spey and overhead techniques. A remote river drift is a great place to take your fly-fishing skills to the next level and hook a few nice trout while your at it! Have a look at our freshwater options. Enjoy a day on our raft or experience the freedom of your own personal watercraft.


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MP introduces bill proposing 'binding planning requirements' for flood resilience measures
Michael Donnelly
A Labour MP has submitted a private members' bill seeking to set "binding planning requirements" to ensure consistency across council areas in the use of pre-commencement conditions that require developers to introduce flood resilience measures in their new schemes.
Emma Hardy, the MP for Kingston upon Hull West and Hessle, yesterday delivered the first reading of her Flooding (Prevention and Insurance) Bill to the House of Commons.
The bill, which is yet to be published in full, is titled: "A Bill to set national minimum requirements for flood mitigation and protection measures in new build public and private properties enforced by local planning authorities; to place reporting requirements on local and national government in relation to flood prevention measures; to establish a certification scheme for improvements to domestic and commercial properties for flood prevention and mitigation purposes and an accreditation scheme for installers of such improvements; to require insurers to take account of such improvements and any existing flood prevention and mitigation measures that were planning permission requirements when determining premiums; to extend eligibility to the Flood Reinsurance scheme under section 64 of the Water Act 2014 to small and medium-sized enterprises and homes built after 2009; and for connected purposes."
In her speech to the house, Hardy said that amongst its purposes, the bill would "set out binding planning requirements for properties, enforced by local authorities".
She explained that, currently, "provided that they are within the scope of current planning law, the property flood resilience measures required in new build properties are... set by local planning authorities in pre-commencement conditions. That results in adjacent local authorities having different requirements in flood zones with the same rating, which is not only inconsistent but hampers collaboration by allowing local authorities to export their flood-related problems to other areas".
Notes on the bill, provided by Hardy's parliamentary office, say that councils can currently "choose what property flood resilience (PFR) measures are required in new build through pre-commencement conditions".
Hardy said that her bill would "create a level playing field by setting minimum standards nationwide".
The MP said that she hoped these minimum standards would be based on "measures put in place by Hull City Council and those supported by the Association of British Insurers, which is calling for the government to enact schedule 3 to the Flood and Water Management Act 2010, and align planning policy related to sustainable drainage systems, as recommended by the [government's climate change advisors] the Climate Change Committee."
The provisions of the 2010 act make the use of sustainable drainage in all new developments mandatory and provide a mechanism for adoption and maintenance. However, it has not been implemented in England.
In July 2019, the Climate Change Committee recommended that the National Planning Policy Framework (NPPF) and planning practice guidance (PPG) be updated to ensure that sustainable urban drainage systems (SuDS) installations "maximise their impact in terms of flood risk reduction and their co-benefits. This could be done by aligning the NPPF and PPG with the aims of Schedule 3 of the Flood and Water Management Act (2010)."
Hull's local plan states that "all development should incorporate sustainable drainage systems (SuDS) unless it has been demonstrated this is not technically or economically feasible".
Although SuDS are not a mandatory requirement in new developments, the government's recently-published national guidance said that "ideally" water "needs to be captured for use on site for irrigation and non-potable uses". The NPPF states that development should incorporate sustainable drainage systems "unless there is clear evidence that this would be inappropriate".
Hardy said that the "common-sense move" to strengthen planning policy requirements for SuDS "is supported by both the insurance industry and Flood Re in its most recent review, and it can be supported by members on both sides of the House. It is about prevention not cure, and it is about building homes that are fit for a changing future."
Elsewhere, Hardy said that, at present, "there is no mandatory requirement for insurers to lower premiums for homes where flood risk is mitigated by flood resilience or protection measures. That is largely due to lack of evidence, both at a landscape scale and at the level of individual properties."
To remedy this, Hardy said that her bill would make the "relevant government agencies" make "readily available the information on all flood prevention and mitigation measures in place regionally and locally".
Hardy said that, collectively, she hoped that the measures set out in the bill would "make it impossible to build a house without adequate flood protections".
The bill's second reading is set for 14 January.
Private members' bills rarely make it through the legislative process and are often used by MPs to raise awareness of issues.
This article originally appeared in ENDS Report's sister title Planning Magazine
The debrief: How a flood defence project plans to protect an industrial hub and deliver environmental gain
A flood defence project, covering a 17-kilometre stretch of coastline in the south-west, is seeking to protect an 'internationally significant' economic area from rising sea levels and deliver environmental gain
'Adapt or die': EA warns people will die unless UK does more to prepare for climate change
The Environment Agency has issued a stark warning to the government that environmental regulation is 'not ready for a changing climate' and that people will die unless more is done to adapt the UK to increases in extreme weather forecast over the coming decades
Planning & land use
'A UK first': Wales planning policy updated to reflect climate change flood risk
Developers in Wales will have to take into account the risk posed by potential climate change induced flood and coastal erosion to have their plans approved, according to new guidance


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Q: What is Iphone help file format As we know the help file format on windows is .chm
What is the help format on iphone?
Best Regards
interdev

A: HTML using PastryKit
http://help.apple.com/iphone/3/mobile/
http://daringfireball.net/2009/12/pastrykit


This 100% Organic & Natural Hair Growth Essence Formula features so many benefits!
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Mix 4-6 drops with shampoo, then massage onto scalp for 3 minutes to make the essence to absorb well on the scalp OR Add 3-6 ml Hair Growth Essence Into 100ml Shampoo (Natural / Organic) and Mix Evenly.
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Then Rinse off With Warm Water. Can Be Used for Daily Hair Wash.


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Movies directed by William A. Graham
Change of Habit (1969)
88 mins Crime, Drama
"Change of Habit" was Elvis's 31st movie and the last proper movie which he starred in, it was actually part of a deal which his manager struck with NBC in return for his 1968 TV special. To be honest, you can see through Elv...
Women of San Quentin (1983)
97 mins Drama, TV Movie
Women of San Quentin (1983) Debbie Allen stars as of the women guards at San Quentin prison who find themselves in the thick of it when rival cultures cause a riot...
Calendar Girl Murders (1984)
92 mins Crime, Drama, Mystery, TV Movie
"Calendar Girl Murders" has one of those tantalising titles which suggest something which might be a little sexy. "Calendar Girl Murders" also has the tantalising prospect of featuring Sharon Stone before she became a big sta...
Billy the Kid (1989)
96 mins TV Movie, Western
The story of William Bonney (aka: Billy the Kid) is such an interesting one that despite it having been covered several times on the big and small screen each version has its merits. When it comes to this 1989 TV version base...
Return to the Blue Lagoon (1991)
98 mins Adventure , Drama, Romance
I can sort of see why after 11 years they decided to make a sequel to "The Blue Lagoon", partly to give a new generation that same magical feeling and partly to elaborate on the story. But what that means is that "Return to t...
Bed of Lies (1992)
100 mins Drama, TV Movie
I should think I have watched at least a dozen movies based on true stories where the poor woman married into society and then ends up on trial for murder. It makes me think that every time a rich white dude gets killed and i...
Death of a Cheerleader (1994)
So let's get some facts down to start with "Death of a Cheerleader" is inspired by a true story but is not a direct dramatization of it. It also starts with the murder of Stacy a series of scenes which are unfortunately very ...
Betrayed: A Story of Three Women (1995)
I can picture it now, the bosses of a studio sitting around a table with their writers trying to come up with new ideas. The middle age woman whose life is rocked by an affair has been done as has the variation of the affair ...
Midwest Obsession (1995)
Midwest Obsession (1995) (aka: Beauty's Revenge) Courtney Thorne-Smith stars in this true story movie about a dangerously obsessed young woman...
Terror in the Shadows (1995)
87 mins Drama, Thriller, TV Movie
So here we go with another made for TV movie which is doing "The Hand That Rocked the Cradle" thing with a psycho seeking insane revenge on someone and in no hurry to inflict that revenge but preferring to doing some stalking...
The Man Who Captured Eichmann (1996)
96 mins Drama, TV Movie, War
So I've mentioned it before but feel that I should mention it again, my historical knowledge is extremely basic and as such had never even heard of Adolf Eichmann. But after coming into possession of two movies with "Eichmann...
Sleeping with the Devil (1997)
Movie Review - Sleeping with the Devil (1997) true story movie starring Shannen Doherty as the rape victim who years later ends up in a relationship with the charming Dick (Tim Matheson) unaware that he has a controlling and ...
Dying to Belong (1997)
Movie Review - Dying to Belong (1997) Hilary Swank, Sarah Chalke, Jenna von O� and Mark-Paul Gosselaar star in this made for TV movie inspired by a true story involving a student's death from a college hazing and the followin...
* This is purely a list of reviews on The Movie Scene featuring the name William A. Graham as one of the directors.
1 pages	/ 13 reviews
Simple list of William A. Graham movies
RANDOM MOVIE QUOTE
Keeping Mum (2005)
MOST READ REVIEWS THIS WEEK
1) Out of Reach (2013)
2) Fatal Friends (2015)
3) Evidence of Truth (2016)
4) Dangerous Lessons (2016)
5) Reflections (2008)
6) 911 Nightmare (2015)
7) The Ultimate Sin (2007)
8) Abducted (2015)
9) The Promise (1999)
10) The Other Mother (2017)
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The BCCLA Liberty Awards are given to individuals and/or entities who have made exceptional contributions to human rights and civil liberties in Canada.
The Liberty Award recipients are devoted in their own ways to the cause of protecting and expanding hard-won democratic rights and freedoms; their collective contributions are invaluable – and essential – to the work of the BC Civil Liberties Association.
Without their principled, creative and often courageous efforts to do right and seek justice, we would have a less free society.
Nominations are welcome from all BCCLA members and supporters. They will be voted on by the BCCLA Board of Directors.
Nominations shall be submitted by completing the form below. Send any questions you might have to [email protected]!
Nominations for the 2018 Liberty Awards close on February 15, 2018.
Is the nominee aware that you are submitting this nomination?
If selected, do you think the nominee would be willing and able to attend the 2018 Liberty Awards Gala happening on May 17, 2018 at the Villa Amato in Vancouver?


Punjab police SHO started crying when he came to hospital and doctor injecting him. According to the details, a police officer was suffering in fever and he went to a hospital for treatment, where doctor injected him, and during injecting he give a very funny expression and start crying. This video become viral on internet. Watch the video from below.


With the explosion of the New media technology it has also brought along new entrepreneurship spirit. This made the Young and New Entrepreneurs to enter the business scene. Some achieved big goals and attained massive success, which exceeded those from the baby boomer generation.


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Home/Disasters & Accidents/Hurricane Ida leaves 1 dead, plunges New Orleans into darkness
Hurricane Ida leaves 1 dead, plunges New Orleans into darkness
Miami, US, Aug 30 (EFE).- At least one person has died and the entire city of New Orleans was left without power on Sunday after Hurricane Ida's passage caused serious damage to transmission lines, local authorities reported.
The death of a 60-year old man occurred in Ascension Parish, in southeastern Louisiana, after a tree fell on his house, according to authorities.
Ascension Parish is part of the Baton Rouge metropolitan area, a region that is expected to receive the worst of Hurricane Ida until early Monday, according to the National Weather Service.
Catastrophic damage was also reported in wide swaths of that area of Louisiana on Sunday night after Hurricane Ida struck the state. The governor said it was "one of the strongest storms to make landfall here in modern times."
All of New Orleans was without power, the city's electricity company said, threatening its sewer system.
The incident occurred just as dusk began to fall and Hurricane Ida was passing about 30 miles (50 kilometers) west of the city.
New Orleans' emergency preparedness campaign NOLA Ready said that the only power in the city is coming from generators.
There are more than 780,000 customers without power in the entire state of Louisiana, according to the specialized website poweroutage.us, although other media put the number of affected at over 1 million.
The outages are presumably due to system failures such as the one in New Orleans or the falling of numerous electricity poles.
This number is expected to increase in the coming hours as Ida continues to move north towards the interior of the region.
Hurricane Ida's landfall at noon accompanied by winds of 150 miles per hour (240 kph) coincided with the anniversary of the havoc wreaked by Hurricane Katrina in the city in 2005.
The storm surges produced by Katrina, which made landfall on Aug. 29 of that year, caused the levee system built to protect the city from storm surges to fail and led to major flooding that killed more than 1,800 people.
Meanwhile, Ida maintained its Category 4 landfall strength for several hours and is generating maximum sustained winds of 115 mph, according to the latest bulletin from the National Hurricane Center (NHC).
Although its winds have weakened, storm surge and heavy rainfall pose the greatest danger to the city, especially now that the storm's speed has slowed to 9 mph. This causes the storm to dump more rain in one place, which increases the chances of water accumulation.
In its latest bulletin, the NHC warned that a "catastrophic storm surge, extreme winds and flash flooding continue in portions of southeastern Louisiana" due to the passage of Ida. EFE
abm/pd/tw
ADDS PHOTOS) EFE HURRICANES ATLANTIC (UPDATES TEXT)
At least 50 children killed in Pakistan boat capsize
Australia's nuclear safety agency joins search for radioactive capsule
Authorities work to identify Pakistan bus crash victims
Indelible wounds from Beirut's explosion


Taylor Swift Finally Found Someone To Play Scrabble With. Love Stories Do Come True!
Taylor Swift Teams Up With Ed Sheeran + Future in "End Game" Music Video!
Taylor Swift doesn't come to play. She sees it all.
Taylor Swift + Ed Sheeran Perform Together At Jingle Ball!
Watch the entire set and see the pictures!
Reputation is more than just an album, it's advice, it's hope, it's courage to stick up for yourself and bravery to do what you feel in your heart is right. So listen to each song as it should be listened to, for its content and meaning, rather than the latest gossip.
Jingle Ball Performers Announced For All Cities!
Check out all 13 cities!


text:
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      break;
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      supportedLocale === def) {
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  return [supportedLocale, def];
}