text:
(function() {
  var CompositeDisposable, Emitter, Model, PaneAxis, Serializable, flatten, ref,
    extend = function(child, parent) { for (var key in parent) { if (hasProp.call(parent, key)) child[key] = parent[key]; } function ctor() { this.constructor = child; } ctor.prototype = parent.prototype; child.prototype = new ctor(); child.__super__ = parent.prototype; return child; },
    hasProp = {}.hasOwnProperty;

  ref = require('event-kit'), Emitter = ref.Emitter, CompositeDisposable = ref.CompositeDisposable;

  flatten = require('underscore-plus').flatten;

  Serializable = require('serializable');

  Model = require('./model');

  module.exports = PaneAxis = (function(superClass) {
    extend(PaneAxis, superClass);

    atom.deserializers.add(PaneAxis);

    Serializable.includeInto(PaneAxis);

    PaneAxis.prototype.parent = null;

    PaneAxis.prototype.container = null;

    PaneAxis.prototype.orientation = null;

    function PaneAxis(arg) {
      var child, children, flexScale, i, len, ref1;
      ref1 = arg != null ? arg : {}, this.container = ref1.container, this.orientation = ref1.orientation, children = ref1.children, flexScale = ref1.flexScale;
      this.emitter = new Emitter;
      this.subscriptionsByChild = new WeakMap;
      this.subscriptions = new CompositeDisposable;
      this.children = [];
      if (children != null) {
        for (i = 0, len = children.length; i < len; i++) {
          child = children[i];
          this.addChild(child);
        }
      }
      this.flexScale = flexScale != null ? flexScale : 1;
    }

    PaneAxis.prototype.deserializeParams = function(params) {
      var container;
      container = params.container;
      params.children = params.children.map(function(childState) {
        return atom.deserializers.deserialize(childState, {
          container: container
        });
      });
      return params;
    };

    PaneAxis.prototype.serializeParams = function() {
      return {
        children: this.children.map(function(child) {
          return child.serialize();
        }),
        orientation: this.orientation,
        flexScale: this.flexScale
      };
    };

    PaneAxis.prototype.getFlexScale = function() {
      return this.flexScale;
    };

    PaneAxis.prototype.setFlexScale = function(flexScale1) {
      this.flexScale = flexScale1;
      this.emitter.emit('did-change-flex-scale', this.flexScale);
      return this.flexScale;
    };

    PaneAxis.prototype.getParent = function() {
      return this.parent;
    };

    PaneAxis.prototype.setParent = function(parent) {
      this.parent = parent;
      return this.parent;
    };

    PaneAxis.prototype.getContainer = function() {
      return this.container;
    };

    PaneAxis.prototype.setContainer = function(container1) {
      this.container = container1;
      return this.container;
    };

    PaneAxis.prototype.getOrientation = function() {
      return this.orientation;
    };

    PaneAxis.prototype.getChildren = function() {
      return this.children.slice();
    };

    PaneAxis.prototype.getPanes = function() {
      return flatten(this.children.map(function(child) {
        return child.getPanes();
      }));
    };

    PaneAxis.prototype.getItems = function() {
      return flatten(this.children.map(function(child) {
        return child.getItems();
      }));
    };

    PaneAxis.prototype.onDidAddChild = function(fn) {
      return this.emitter.on('did-add-child', fn);
    };

    PaneAxis.prototype.onDidRemoveChild = function(fn) {
      return this.emitter.on('did-remove-child', fn);
    };

    PaneAxis.prototype.onDidReplaceChild = function(fn) {
      return this.emitter.on('did-replace-child', fn);
    };

    PaneAxis.prototype.onDidDestroy = function(fn) {
      return this.emitter.on('did-destroy', fn);
    };

    PaneAxis.prototype.onDidChangeFlexScale = function(fn) {
      return this.emitter.on('did-change-flex-scale', fn);
    };

    PaneAxis.prototype.observeFlexScale = function(fn) {
      fn(this.flexScale);
      return this.onDidChangeFlexScale(fn);
    };

    PaneAxis.prototype.addChild = function(child, index) {
      if (index == null) {
        index = this.children.length;
      }
      child.setParent(this);
      child.setContainer(this.container);
      this.subscribeToChild(child);
      this.children.splice(index, 0, child);
      return this.emitter.emit('did-add-child', {
        child: child,
        index: index
      });
    };

    PaneAxis.prototype.adjustFlexScale = function() {
      var child, i, j, len, len1, needTotal, ref1, ref2, results, total;
      total = 0;
      ref1 = this.children;
      for (i = 0, len = ref1.length; i < len; i++) {
        child = ref1[i];
        total += child.getFlexScale();
      }
      needTotal = this.children.length;
      ref2 = this.children;
      results = [];
      for (j = 0, len1 = ref2.length; j < len1; j++) {
        child = ref2[j];
        results.push(child.setFlexScale(needTotal * child.getFlexScale() / total));
      }
      return results;
    };

    PaneAxis.prototype.removeChild = function(child, replacing) {
      var index;
      if (replacing == null) {
        replacing = false;
      }
      index = this.children.indexOf(child);
      if (index === -1) {
        throw new Error("Removing non-existent child");
      }
      this.unsubscribeFromChild(child);
      this.children.splice(index, 1);
      this.adjustFlexScale();
      this.emitter.emit('did-remove-child', {
        child: child,
        index: index
      });
      if (!replacing && this.children.length < 2) {
        return this.reparentLastChild();
      }
    };

    PaneAxis.prototype.replaceChild = function(oldChild, newChild) {
      var index;
      this.unsubscribeFromChild(oldChild);
      this.subscribeToChild(newChild);
      newChild.setParent(this);
      newChild.setContainer(this.container);
      index = this.children.indexOf(oldChild);
      this.children.splice(index, 1, newChild);
      return this.emitter.emit('did-replace-child', {
        oldChild: oldChild,
        newChild: newChild,
        index: index
      });
    };

    PaneAxis.prototype.insertChildBefore = function(currentChild, newChild) {
      var index;
      index = this.children.indexOf(currentChild);
      return this.addChild(newChild, index);
    };

    PaneAxis.prototype.insertChildAfter = function(currentChild, newChild) {
      var index;
      index = this.children.indexOf(currentChild);
      return this.addChild(newChild, index + 1);
    };

    PaneAxis.prototype.reparentLastChild = function() {
      var lastChild;
      lastChild = this.children[0];
      lastChild.setFlexScale(this.flexScale);
      this.parent.replaceChild(this, lastChild);
      return this.destroy();
    };

    PaneAxis.prototype.subscribeToChild = function(child) {
      var subscription;
      subscription = child.onDidDestroy((function(_this) {
        return function() {
          return _this.removeChild(child);
        };
      })(this));
      this.subscriptionsByChild.set(child, subscription);
      return this.subscriptions.add(subscription);
    };

    PaneAxis.prototype.unsubscribeFromChild = function(child) {
      var subscription;
      subscription = this.subscriptionsByChild.get(child);
      this.subscriptions.remove(subscription);
      return subscription.dispose();
    };

    PaneAxis.prototype.destroyed = function() {
      this.subscriptions.dispose();
      this.emitter.emit('did-destroy');
      return this.emitter.dispose();
    };

    return PaneAxis;

  })(Model);

}).call(this);

redpajama_set_name: RedPajamaGithub


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We have partnered with the LGPS pension funds of Cheshire, Leicestershire, Nottinghamshire, Shropshire, Staffordshire, Worcestershire and West Midlands to form a collective investment pool, known as LGPS Central Pool (the pool), in accordance with government requirements for the pooling of LGPS investment assets.
To provide oversight of the delivery of the objectives of the pool, the delivery of client service, the delivery against the LGPS central business case and to deal with common investor issues, the joint committee provides assistance, guidance and recommendations to the individual councils, taking into consideration the conflicting demands and interests of the participants within the pool. The joint committee does not have delegated authority to make binding decisions on behalf of the participating councils.
Membership of the joint committee consists of one elected member from each participating council. The vice chair of the Pensions and Investments Committee represents Derbyshire on the LGPS Central Joint Committee.
The clerk to the joint committee is the head of paid service or nominee of Cheshire West and Chester Council.
You can find meeting papers and minutes for the joint committee on the Cheshire Pension Fund website.
To oversee the operation and performance of LGPS Central Ltd and to represent the ownership rights and interests of the shareholding councils with the LGPS Central Pool. Collective shareholder discussions take place in the Shareholders' Forum and aim to ensure that the councils act in a unified way in company meetings, having agreed to a common set of principles. Unanimous decisions are required for certain reserved company matters.
Shareholder Forum meetings are distinct from LGPS Central Ltd company meetings, however members of the Shareholders' Forum also represent the councils at company meetings.
Membership of the Shareholders' Forum consists of one representative from each council.
The chair of the Pensions and Investments Committee represents Derbyshire at the Shareholders' Forum and at LGPS Central Ltd company meetings.
Decisions are made in advance of the Shareholders' Forum and company meetings to enable the council's representative to vote at these meetings. Wherever possible, any matter regarding LGPS Central Ltd which requires a shareholder decision will be taken to the Pensions and Investments Committee for consideration.
Where the timetable does not allow for this, decision making is delegated to the Director of Finance and Information and communications technology (ICT) following consultation with the Chair of the Pensions and Investments Committee.
A working group of officers appointed by the shareholding councils within the pool to support the delivery of the objectives of the pool and to provide support for the pool's joint committee and Shareholders' Forum.
The Director of Finance and ICT, the Head of Pension Fund and the Investments Manager represent Derbyshire on the Practitioners' Advisory Forum as required.


Over the past few months we've been tweaking and perfecting the Mighty Mold system, and the time is finally here! Beginning in the month of March, you'll be able to pre-order molds directly from our cart, and we'll begin shipping out orders starting April 1st – no foolin'!
This launch marks a turning point both for our company, and for the soap and candle making communities. We asked for your support, and you answered, helping us create a mold system that we all can be truly proud of. Over the next few weeks, we will begin running polls and contests to find out what our next mold offerings will be!
Included in our launch event will be soap molds, such as the Tall and Skinny Loaf Soap Mold, and the Square Bar Soap Mold, both of which feature the effortless release properties of all Mighty Molds. Additionally, these molds feature innovations such as inset walls that are sure to change the way people think about loaf molds in the future. The extra wide mouth pour spout of the Square Bar Mold is especially helpful to cold process soap makers who use thicker recipes and batters, but still want to create uniform, fully formed bars straight from the mold.
We haven't forgotten about candle makers in our initial releases, as we've included the Taper Candle Mold as well. Boasting our game-changing internal wicking system and release properties that are completely unheard of, these taper candle molds are something we are especially proud of. This particular mold in particular truly embodies the Mighty Mold mission – making candle and soap making easier, faster, and more productive than ever before!
Our final offering for this initial release is our Dragon Egg Mold. Easily the most versatile mold we've ever created, dragon eggs can now be made as both candles and soap at the exact same time, with the added bonus of being able to use the mold "open" and make half-eggs! Create fully formed, 3D dragon eggs in a single pour, or switch things up and make flat backed half-eggs that fit the hand oh-so-perfect. Regardless of what you make, the Mighty Molds Dragon Egg Mold will release your creation effortlessly, and without damaging the hard work you've put into it.
So Much Silicone - So Much Saving!!


Summary: President Gorbachev talked of the opportunity for peace in the wake of the Cold War and the Gulf War - but warned that the Madrid conference would only succeed if all parties work together for a durable peace. He reiterated the US statement that a durable peace implies the implementation of and respect for the rights of the Palestinian people; and also requires the recognition of the state of Israel.
I'd also like to begin with an expression of my gratitude to our hosts, the King of Spain and the Spanish government, for their offer of Madrid as the venue for this Conference, a Conference of such importance to the entire world. It would have been difficult to select a better venue from the standpoint both of the country's prestige and authority and of the geopolitical factor, too.
I welcome here the presence of the President of the United States of America, the Arab delegations and observers, the Israeli delegation, Representatives of the European Community and of the United Nations Secretary-General. The composition of the participants, as well as the nature and objectives of this Conference, are eloquent testimony to the fact that we are participants in an event of major importance in new world politics.
The road to this point was strewn with thousands of victims and with devastations and calamities suffered by whole peoples. It was marred by hatred and atrocities, and many were the crossroads on the path that were fraught with danger of global conflagration. This conflict, the longest in the latter half of the twentieth century, bears the heavy stamp of the so-called Cold War, and it was not until an end was put to that, that ending this conflict became a tangible possibility, too. However, enormous efforts were needed to put on track the process of reaching out towards a settlement. Those efforts reflected the tremendous potential of goodwill and the sense of responsibility of the statesmen and policymakers and of all those who became involved in this undertaking of global importance, for the region of which we speak is a region from which originate many sources of the world's millennial civilization and culture and where the vital interests of today's international community converge. It's a region inhabited by nations whose genius has furnished some of the greatest achievements of the human spirit.
I must say a few words about the role of the two powers whose presidents are now before you as co-chairmen of the Conference. It was the will of history that, without an improvement and then a radical change in Soviet-U.S. relations, we would never have witnessed the profound qualitative changes in the world that now make it possible to speak in terms of an entirely new age, an age of peace in world history. Movement in that direction has begun, and it is only in this context that we can understand the fact that a tangible hope has emerged for an Arab-Israeli settlement.
Cooperation between the two powers and other members of the U.N. Security Council was indispensable in order to stop the aggression against Kuwait and to reaffirm the viability of our new criteria in international relations. Directly after that, just as was agreed between President Bush and myself in September 1990 at our Helsinki meeting on the subject of the Gulf War, vigorous joint efforts began, aimed at achieving a Middle East settlement. All that we and the Americans have under taken to that end signifies the right conclusions have been drawn from the Gulf War.
Our joint participation in the process of settlement was prompted by a desire to offer our good offices, not any desire to impose solutions from outside that would run counter to the national interests of states in the region. Thus, as a result of major bilateral and multilateral efforts, a signal was sent to the parties involved in the conflict, a signal of the need to negotiate, to work together towards finding a realistic balance of interests which alone may form the foundation for a durable peace.
Today we have a unique opportunity, and it would be unforgivable to miss this opportunity. Success is in everybody's interests, not only because the rights of the peoples and nations and of the individual are increasing[ly] recognized today as the universal foundation for our world order, but also for another reason of particular urgency and gravity, and that is the fact that the Middle East has become one of the most heavily armed regions in the world, where lethal weapons and nuclear technologies are building up, and where other weapons of mass destruction are also to be found.
There is justified cause for alarm. The international community is entitled to expect that this Conference will come up with decisions that will put this concern to rest. In my view, the Conference can only succeed if no one seeks any victory for one side over the other, but all seek a shared victory over a cruel past. I'm speaking of peace, rather than merely a cessation of the state of war, and a durable peace implies the implementation of and respect for the rights of the Palestinian people.
We have restored diplomatic relations with Israel. Now that deep-rooted democratic changes are taking place in our country and in the world, and now that a real process towards settling the Middle East crisis is getting underway, the absence of relations with Israel was becoming senseless. We hope and will try to make sure that this will be of benefit to the peoples of our two countries and the entire Arab world. Peace in the Middle and Near East would benefit all.
The region has vast potential. Turning to constructive pursuits, it will help not only to resolve the problems of the nations that live there, but would also become an important pillar of support for global international progress and prosperity. We must break the fetters of the past and do away with hostility, militarism, terrorism, hostage-taking, and those actions that turn people into refugees.
Our country, as a participant in the Middle East process and a neighbor that has maintained long standing and extensive ties with the nations of the region, has a special stake in the success of this Conference. The pace we set and the way we tackle the problems that have emerged at the present stage of world development will have a strong bearing on the settlement of conflicts in the Middle East and elsewhere.
The acceleration of historical evolution when based on democracy is truly amazing. The tremendous social energy of the masses of people is being released, and typical of the way this is made manifest is the dramatic growth of national self-aware ness and national consolidation, particularly where national feelings were long ignored or suppressed. This is, in general, a positive process that holds out great promise for the future. It will add greatly to the creative potential of the world community in all its diversity.
We now have a far better chance of keeping this process on a civilized course. At the micro level of world politics, there is a recognition of the complex implications of national aspirations and a willing ness to put out the fires of inter-ethnic and inter national conflicts as witnessed in the Middle East, in Southern Africa, in Cambodia, in Korea, Afghanistan, and Central America.
Yet dangers do exist, and we're already facing such dangers. Somewhat unexpectedly, they've made themselves most strongly felt in Europe, but this entirely new international environment means that there's a much lesser temptation for any outsiders to exploit, say, the Yugoslav crisis in order to gain some advantage and strengthen their own hand at others' expense. On the contrary, the dominant tendency is to exert joint and vigorous efforts to help overcome the crisis, while respecting the right of the parties involved to decide the future destiny of their country and at the same time reminding them of their responsibility to the international community.
One may hope that crises arising in our time will not be as protracted as the one we're dealing with here. Of late, the world has been confronted by yet another crisis of tremendous proportions. What I have in mind is my own country. It became inevitable as a result of latent contradictions building up over a long period of time. A great country is going through a great transformation. It's a painful and arduous process which has brought about personal tragedies and inter-ethnic and regional conflicts. Much in the world depends on how our crisis will be resolved.
Once this crisis is overcome, our union will acquire new qualities and potential as a world power based materially on a market economy as part of the world economy, politically on democracy as part of universal democracy, and intellectually on the new thinking. We are the ones who will shoulder the main burden of achieving the recovery and prosperity of our country.
This job is for us to do. Our peoples will have to go through a difficult period of transition, but it's important that, under the new conditions created because it was our country that launched the initiative to end confrontation and to join up with the rest of the world, that the world, too, has not remained indifferent to our great cause. The world community is becoming increasingly aware that what is happening in the Soviet Union has a larger bearing than any regional conflict on the vital interests of the greater parts of today's world. Today, we hear not only murmurs of approval and good wishes. We are also beginning to see practical support as well. And this is a very significant sign of the movement towards a new era, a new age. And President Bush's initiative regarding nuclear arms, with our reciprocal initiatives, constitutes a major step and a prescient symbol of this movement.
For almost half a century nuclear arms used to be the axis upon which world politics turned. The task is now by changing the nature of those politics to replace it with something completely new and more attuned with the wheels of 21st century history.
Mankind faces many peacetime challenges. All of them are formidable ones. And they include all what we call global problems: the environment, energy, food supplies, population, all the problems of development, and the total abolition of the nuclear threat, which is spreading to the edges from the former center of world confrontation. All these challenges can only be met through joint efforts. Therefore, it is essential to fracture the logic of so many millennia, and particularly the logic of this century, persistently and patiently, to shape a new logic of interdependence, interaction, and cooperation. But this task is an extremely difficult one. We see both in our country and elsewhere, even here at this Conference, ghosts of the old thinking, sometimes unnoticed, are still present among us. When we rid ourselves of their presence we will be better able to move towards a new world order. And irrespective of our individual vision of this new order, it appears that we should now promote this objective process itself, relying on the relevant mechanisms of the United Nations, the CSCE, the European Community's modernized, old, and completely new structures of regional security and cooperation, as well as the institutions created for crisis prevention and conflict settlement.
Ladies and Gentlemen, it is for the delegations directly participating in the Conference to sort out the details of this enormous task. As co-chairmen of the Conference, we will be in regular contact with our American counterparts, and we will do our utmost to find solutions for which your peoples and the entire world have long been yearning. In my address I've mentioned the more general problems of the global process. I did this in order to emphasize once again the important international context of this Conference and of the challenge which you are facing. I wish you every success.


text:
New TOS Novel, The Weight of Worlds, Out Today
The latest literary Star Trek adventure is available now. Star Trek: The Original Series – The Weight of Worlds is out today from Simon & Schuster/Pocket Books. Penned by bestselling author Greg Cox (Star Trek: The Rings of Time), it's a mass market paperback and eBook that runs 352 pages and sells for the suggested retail price of $7.99. Here's the synopsis direct from Simon & Schuster/Pocket Books:
The Ephrata Institute is an intellectual think tank at the outer fringes of the final frontier. Dedicated to the arts and sciences, the Institute seems an unlikely target for an invasion, but it proves easy pickings when the Crusade comes from beyond, determined to impose its harsh, unbending Truth on all the worlds of the Federation. Armed with weaponized gravity, the alien Crusaders will stop at nothing to rescue the universe from its myriad beliefs… even if it means warping the mind and soul of every sentient being they encounter.
Responding to an urgent distress signal, Captain James T. Kirk and the crew of the U.S.S. Enterprise soon find themselves in conflict with the Crusade, and facing individual challenges. When Kirk and Spock are transported to the Crusade's distant homeland to confront the source of the invasion, Sulu finds himself trapped behind enemy lines, while Lieutenant Uhura is faced with possibly the most difficult decisions of her career.
As the Crusade sets its sights beyond Ephrata IV, it is up to the Enterprise and its besieged crew to keep freedom of thought from being crushed beneath the weight of worlds!
Click HERE to order The Weight of Worlds.
Greg Cox

redpajama_set_name: RedPajamaCommonCrawl


The Ray D'Arcy Show reaches more than 220,000 listeners who tune in daily from 3.00 – 4.30 p.m. to hear from one of Ireland's most well-known media personalities.
As part of our sponsorship, Allcare Pharmacy will be featured on air through five 10-second 'stings' – short but impactful ads – each day. These stings will highlight the great things customers and patients experience in Allcare community pharmacies across the country.
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text:
Peter Jackson Restores The Beatles in New Doco 'The Beatles: Get Back'
By Nick Janks
The Career of Disco Kings the Bee Gees is Explored in New Documentary
The Bee Gees: How Can You Mend a Broken Heart takes a deep look at the iconic band that conquered the music world.
Netflix's 'The Social Dilemma' Trailer is Here to Scare You Off Social Media
The Social Dilemma is a new Netflix documentary that outlines the darker aspects of highly addictive social media platforms.
Outrageous 90's Series 'The Ren & Stimpy Show' Gets a Documentary
Iconic 90's cartoon The Ren & Stimpy Show is the subject of the new documentary film Happy Happy Joy Joy: The Ren & Stimpy Story.
'Strangers to the World' Docu-Drama Showcases Bravery Against Evil
By Núria Falcó
Survival is a natural instinct found in every animal, including us humans. However, what happens when in order to survive, one needs to switch off feelings and resign one's conscience? Would you sacrifice everything to stay true to yourself? Even if it will certainly lead to your death?
'Paradise Without People' Documentary Review - A Moving Refugee Story
It's hard to imagine giving birth in a foreign land, without one's relatives or a home. Having had to flee a war-torn country, leaving everything behind. That's the reality of many Syrian women who fled from a devastating war that led to a refugee crisis.
Melbourne Documentary Film Festival ONLINE - 2020 Highlights
The Melbourne Documentary Film Festival is back for 2020 with a new online only format and it features some very intriguing documentaries.
Media Under Investigation in Netflix Docuseries 'Trial By Media' – Review
By Alaina Dean
There's no denying that the world has gone crazy for true crime. Whether it's streaming on Netflix, docudramas on the big screen, or investigative podcasts, we can't seem to get enough of the genre.
Michael Jordan Documentary 'The Last Dance' Review - Episodes 1 & 2
ESPN has teamed up with Netflix to release the Michael Jordan documentary series The Last Dance, which follows the basketball legend and his team the Chicago Bulls through the 97-98 NBA season.
'The Last Dance' Series Highlights Jordan's 6th NBA Championship Run
The Last Dance follows Michael Jordan and the Chicago Bulls on a run for their sixth NBA championship title during the 1997-1998 season with unprecedented behind-the-scenes access.
'Citizen K' Documentary Charts the 'Gangster Capitalism' Era in Russia
By Aly AW
Alex Gibney's latest documentary Citizen K is educational yet unsatisfying. This documentary tries to fit Russian oligarch Mikhail Khodorkovsky's story into 2 hours (which is definitely not an easy task) – from his rise to financial power in the early days of capitalism to facing off and creating a nemesis no one would dare to touch in Vladimir Putin.
'Honeyland' is a Mesmerizing Documentary About Man and Nature
The astonishingly gorgeous documentary film, Honeyland, explores the life of Europe's last beekeeper, and her struggle to face mankind's flawed condition against nature.
Confronting Documentary 'Wild Butterfly: The Claire Murray Story' Review
Wild Butterfly is a devastating documentary uncovering the truth behind the controversial case of Claire Murray, a Western Australian 24-year-old mother-of-two who needed a liver transplant in order to stay alive.
'For Sama' is a Harrowing War Documentary that Remains Hopeful
Waad, the film's narrator, tells her life story during the five years of uprising in Aleppo, and the siege which forced her to experience the destruction of her home city in For Sama.
'The Biggest Little Farm' is Heartwarmingly Educational - Review
Throughout The Biggest Little Farm, I was in tears. The film details the damage monoculture farming has on the land and the despair that this creates is immense. However, the film is also careful to create a sense of joy out of the simplicity of nature, and its ability to heal itself with the right human care.
'Monster Hunter' Review – Uninspired Adaptation of Popular Video-Game
Sia's Vanity Project 'Music' Can't Find the Right Narrative Balance
'A Call to Spy' Review – A Factual WWII Spy Drama with Little Intrigue
'Wonder Woman 1984' Review – Grand Storytelling at its Finest
Apple Original Film 'Wolfwalkers' is a Fresh and Enjoyable Animation
New 'IT' Movie Featurette Video – 'Face Your Fears'
'Camino Skies' Review - A Touching Exploration on Mortality
'The Australian Dream' - Adam Goodes Documentary Pulls No Punches
Tim Burton's Disney Remake 'Dumbo' Soars - Review
'An Interview with God' Keeps the Faith - Review
No clickbait, no gossip, no drama. Janks Reviews offers only the latest in spoiler-free film reviews, trailers, videos, and feature articles for your reading and viewing pleasure.
See the Rise of the Black Panther Party in 'Judas and the Black Messiah'
Tom Holland Leads Intriguing New Russo Brothers Crime Drama 'Cherry'
Impressive Cast Features in Crime Caper 'Breaking News in Yuba County'
Janks Reviews | Contribute


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Cotoneaster horizontalis Decne.
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Article from Bean's Trees and Shrubs Hardy in the British Isles
Bean's Trees and Shrubs
A deciduous shrub of low, flat habit, rarely more than 2 or 3 ft high in the open, the branches spreading quite horizontally, and increasing but slowly in height; branchlets covered with a thick brown wool, and produced in two opposite rows. Leaves roundish or broadly oval, from 1⁄4 to 1⁄2 in. long, three-fourths as wide, shortly and abruptly pointed; dark glossy green above, glabrous, or with a few scattered hairs beneath. Flowers white, suffused with pink, about 1⁄4 in. diameter, produced during May singly, or in pairs on short leafy twigs springing from the buds of the previous summer's wood; calyx woolly. Fruit globose, bright red, about 1⁄5 in. diameter, nutlets three.
Native of China; described from plants in the garden of the Paris Museum, raised from seed sent by the missionary Père David around 1870 and put into commerce in France in 1885. This is decidedly one of the prettiest and most distinct of cotoneasters. Its most striking characteristic is the opposite branching and low, horizontal habit. The leaves, although small, are so abundant as to be almost without intervening spaces; they remain long on the branches, and the shrub is often in full leaf in November. Then the lower ones of each shoot begin to fade off into various shades of orange and red, whilst the terminal part retains them green. By January the shrub, as a rule, has lost all its foliage, and its bare branches present a curious fish-bone-like appearance. The fruits are very bright, and often abundant, although smaller than in most of the species. In the open ground, where it has plenty of space to develop, this cotoneaster keeps low and flat, but it will grow much higher against a wall. In such a position there is a plant at Kew 10 ft high spreading over the wall, but keeping from actual contact with it. Increased easily by cuttings.
var. perpusillus Schneid. C. perpusillus (Schneid.) Flinck & Hylmö – A pleasing variety introduced by Wilson from W. Hupeh, China, in 1908. It differs from the typical plant in its smaller leaves which are 1⁄4 in. or less in length. Wilson informed us that this variety is the common cotoneaster of the moorlands in its native home, being abundant in open rocky ground. He thought it may be merely a climatic form which under cultivation may revert to the type – as so often happens with depauperate forms. Up to the present, however, it is distinguishable.
cv. 'Saxatilis . – Dwarfer than the type, with the 'fish-bone' habit of branching very well marked; it is also more prostrate and the leaves are smaller. Suitable for the rock garden but shy-fruiting. It was put into commerce by Messrs Hesse of Germany in 1950.
cv. 'Variegatus'. – Leaves edged with white. This is one of the most dainty of variegated shrubs. The low, flat, spreading nature of the growth shows up the variegation very effectively.
In his valuable survey of dwarf cotoneasters (Dendroflora, No. 3, 1966) H. J. Grootendorst also describes 'Robusta', a vigorous and free-fruiting form whose leaves colour well before falling. Put into commerce by Messrs Van Nes in 1954.
C. (horizontalis × salicifolius var. floccosus) 'Gracia' and 'Valkenburg'. – These two hybrids, with horizontalis as the pollen parent, were raised at Boskoop in 1951. Both are triploid and almost sterile, but the second is said to have some value as a semi-evergreen ground-cover. The cross is of interest in that it unites the two sections of the genus.
C. splendens Flinck & Hylmö – This species, described in 1964, was discovered and introduced to Sweden in 1934 by the Swedish botanist Dr Harry Smith from the region of Tatsien-lu (now called Kangting). It is described as an apomictic species allied to C. dielsianus, but differing in its lower growth, in its thinner, broadly ovate-elliptical to almost orbicular leaves with less impressed veins, and in its larger, lustrous, bright orange-red fruits. See also 'Sabrina'.
C. 'Sabrina'. – This cotoneaster arose as a self-sown seedling in the garden of N. G. Hadden, Porlock, and was given an Award of Merit in 1950. It appeared between two cotoneasters, of which one was C. horizontalis; the other was grown as "C. pannosus" but subsequently proved to be C. franchetii (P. F. Yeo in Gard. Chron., April 21, 1962). In their account of C. splendens (see above) the authors remark that, judging from a herbarium specimen of Mr Hadden's plant, 'Sabrina' would appear to be identical with C. splendens and contend that it must have been raised from seed of this species, which has been in cultivation in a number of Scandinavian botanical gardens for some thirty years. This is both interesting and puzzling, since Mr Hadden assures us that his plant was, as stated, self-sown and in his opinion a hybrid between C. horizontalis and C. franchetii. Seedlings of C. splendens and 'Sabrina' are in cultivation in the University Botanic Garden, Cambridge. Dr Yeo tells us that the 'Sabrina' seedlings are uniform and seem to the eye to be very similar to those of C. splendens, though they are tending to produce 'herring-bone' branching, whereas C. splendens has the branches decussate. Until these plants come to maturity the question of the taxonomic position of 'Sabrina' (and of C. splendens) is best left in abeyance.
From the Supplement (Vol. V)
cv.' Variegatus'. – An attractive feature of this cultivar, not noted in the original printing, is that the leaves turn pink in the autumn.
'Cotoneaster horizontalis' from the website Trees and Shrubs Online (treesandshrubsonline.org/articles/cotoneaster/cotoneaster-horizontalis/). Accessed 2020-01-20.
Species Links
Infraspecifics
Cotoneaster horizontalis C (horizontalis × salicifolius
Cotoneaster horizontalis C 'Sabrina'
Cotoneaster horizontalis C splendens
Cotoneaster horizontalis 'Saxatilis
Cotoneaster horizontalis var. perpusillus
Cotoneaster horizontalis 'Variegatus'
Other species in genus
Cotoneaster acuminatus
Cotoneaster acutifolius
Cotoneaster adpressus
Cotoneaster affinis
Cotoneaster ambiguus
Cotoneaster amoenus
Cotoneaster apiculatus
Cotoneaster bullatus
Cotoneaster buxifolius
Cotoneaster congestus
Cotoneaster conspicuus
Cotoneaster cooperi
Cotoneaster dielsianus
Cotoneaster distichus
Cotoneaster divaricatus
Cotoneaster foveolatus
Cotoneaster frigidus
Cotoneaster glabratus
Cotoneaster glaucophyllus
Cotoneaster harrovianus
Cotoneaster hebephyllus
Cotoneaster henryanus
Cotoneaster hupehensis
Cotoneaster integerrimus
Cotoneaster lacteus
Cotoneaster lindleyi
Cotoneaster lucidus
Cotoneaster melanocarpus
Cotoneaster microphyllus
Cotoneaster moupinensis
Cotoneaster multiflorus
Cotoneaster nitens
Cotoneaster nitidifolius
Cotoneaster obscurus
Cotoneaster pannosus
Cotoneaster prostratus
Cotoneaster racemiflorus
Cotoneaster rhytidophyllus
Cotoneaster rotundifolius
Cotoneaster rubens
Cotoneaster simonsii
Cotoneaster turbinatus
Cotoneaster uniflorus
Cotoneaster zabelii
(pl. calyces) Outer whorl of the perianth. Composed of several sepals.
Lacking hairs smooth. glabrescent Becoming hairless.
globose
globularSpherical or globe-shaped.
There are currently no active references in this article.
C (horizontalis × salicifolius var.
floccosus ) 'Gracia' and 'Valkenburg'
These two hybrids, with horizontalis as the pollen parent, were raised at Boskoop in 1951. Both are triploid and almost sterile, but the second is said to have some value as a semi-evergreen ground-cover. The cross is of interest in that it unites the two sections of the genus.
C 'Sabrina'
This cotoneaster arose as a self-sown seedling in the garden of N. G. Hadden, Porlock, and was given an Award of Merit in 1950. It appeared between two cotoneasters, of which one was C. horizontalis; the other was grown as "C. pannosus" but subsequently proved to be C. franchetii (P. F. Yeo in Gard. Chron., April 21, 1962). In their account of C. splendens (see above) the authors remark that, judging from a herbarium specimen of Mr Hadden's plant, 'Sabrina' would appear to be identical with C. splendens and contend that it must have been raised from seed of this species, which has been in cultivation in a number of Scandinavian botanical gardens for some thirty years. This is both interesting and puzzling, since Mr Hadden assures us that his plant was, as stated, self-sown and in his opinion a hybrid between C. horizontalis and C. franchetii. Seedlings of C. splendens and 'Sabrina' are in cultivation in the University Botanic Garden, Cambridge. Dr Yeo tells us that the 'Sabrina' seedlings are uniform and seem to the eye to be very similar to those of C. splendens, though they are tending to produce 'herring-bone' branching, whereas C. splendens has the branches decussate. Until these plants come to maturity the question of the taxonomic position of 'Sabrina' (and of C. splendens) is best left in abeyance.
C splendens Flinck & Hylmö
This species, described in 1964, was discovered and introduced to Sweden in 1934 by the Swedish botanist Dr Harry Smith from the region of Tatsien-lu (now called Kangting). It is described as an apomictic species allied to C. dielsianus, but differing in its lower growth, in its thinner, broadly ovate-elliptical to almost orbicular leaves with less impressed veins, and in its larger, lustrous, bright orange-red fruits. See also 'Sabrina'.
'Saxatilis
Dwarfer than the type, with the 'fish-bone' habit of branching very well marked; it is also more prostrate and the leaves are smaller. Suitable for the rock garden but shy-fruiting. It was put into commerce by Messrs Hesse of Germany in 1950.
var. perpusillus Schneid.
C. perpusillus (Schneid.) Flinck & Hylmö
A pleasing variety introduced by Wilson from W. Hupeh, China, in 1908. It differs from the typical plant in its smaller leaves which are {1/4} in. or less in length. Wilson informed us that this variety is the common cotoneaster of the moorlands in its native home, being abundant in open rocky ground. He thought it may be merely a climatic form which under cultivation may revert to the type – as so often happens with depauperate forms. Up to the present, however, it is distinguishable.
'Variegatus'
Leaves edged with white. This is one of the most dainty of variegated shrubs. The low, flat, spreading nature of the growth shows up the variegation very effectively.In his valuable survey of dwarf cotoneasters (Dendroflora, No. 3, 1966) H. J. Grootendorst also describes 'Robusta', a vigorous and free-fruiting form whose leaves colour well before falling. Put into commerce by Messrs Van Nes in 1954.
A site produced by the International Dendrology Society.
For copyright and licence information, see the Licence page.
To contact the editors: info@treesandshrubsonline.org.


text:
Missed free throws by Peabody allow Wossman to win 3A semifinal in overtime
LAKE CHARLES — The wrong place and time for one team might mean the right place and time for another.
A combination of missed free throws from Peabody and a timely 3-point shot when things were not going well from behind the arc led to the Wildcats securing a 71-67 win in overtime Thursday in the Class 3A semifinals.
"First off, hats off to Peabody and Coach (Charles) Smith; they're always well-prepared and have a great program," Wildcats coach Casey Jones said. "Whenever we play them, it's always going to be a hard-nosed, tough ballgame."
Wossman missed its first eight 3-pointers of the game, but Rayson Robinson's three with 9.9 seconds left gave it new life as it went 5 of 6 from the floor in overtime.
"(Rayson's) our captain and our unquestioned leader," Jones said. "He leads us on the track, weight room and locker room. He's the first one in there and the last one out and he means so much to this program. I'm ecstatic that he was able to make that big shot."
The play initially was supposed to be Nick Traylor (22 points, 23 rebounds) to see if he could force the Peabody defenders to foul him, but Traylor saw an open Robinson and trusted him to make the shot.
"I saw an open shooter and I trust him enough to make a big-time shot, so I passed it out to him," Traylor said.
While Wossman got over its struggles from long range, the Warhorses missed opportunities from the free-throw line.
Peabody missed the front end of three one-and-ones to keep the Wildcats in the game and went scoreless in the final 2:58 of regulation.
"I knew coming in against Wossman that Coach Jones does a great job with his guys," Peabody coach Charles Smith said. "I knew his guys were going to be ready to play and they were. They didn't quit, and they had to make a big shot to tie the game — they did. We had to make free throws to win the game and they didn't."
Despite their free throw woes, the Warhorses still had a shot to win in regulation, but Flanagan missed the game-winning jumper at the buzzer to set up overtime.
Peabody battled in overtime with Kyron Gibson scoring eight points in the extra period, but the Wildcats matched that with LaJarrion Spinks adding eight points of his own to push them to victory.
Spinks closed with 16 points for the Wildcats, while Gibson had 15 points and seven steals for Peabody. Flanagan led the Warhorses with 20 points.
The Wildcats will face Madison Prep in the Class 3A championship game at 8 p.m. Saturday. The Chargers defeated top-seed Sophie B. Wright, 59-53, in the other semifinal game in Class 3A.


Matt has over 27 years of experience advising small business owners. Serving as the firm's benefit plan specialist, Matt has worked closely with business owners to develop benefit and retirement plan packages. His background in income tax planning, coupled with his knowledge of retirement plan regulations, have enabled him to guide clients through the maze of long-term planning decisions.
Matt obtained his formal education at the University of Akron where he recieved a Bachelor of Science in Accounting and a Masters Degeree in Taxation specializing in taxation for individuals and closely-held corporations. Matt serves as a director for the Tuscarawas Society for Children and Adults, Inc. He serves on the Accounting Technology Advisory Board at Kent State-Tuscarawas and is a founding board member of the Strasburg Tiger Foundation. Outside the office Matt enjoys coaching his three boys in basketball and baseball. Matt resides in Strasburg, with his wife Melanie and three boys, Matthew, Michael and Mitchel.


Short or long, which is better for editors?
If you own a publicity firm, your clients are probably asking you to write articles that can be sent to the media, right?
And if you are a company, you're probably asking your in-house pr person to do the same, or wondering why your publicity agency isn't getting those articles published.
Well, this isn't the only way to get noticed and published, but this suggestion is one method to consider. We call them "briefs".
These are short articles, usually less than 100 words. I share the same opinion as another company, called PR Ideas. He too writes that sending good short briefs can be excellent for editors who need fillers, or just short stories on different topics.
This can also position you or your company as experts in the field. Everyone is busy trying to jam long articles to reporters, publishers and editors. When in fact, they need short articles many times.
I like to think of doing these as a way to help the media people with their job and by showing them we offer a lot of valuable information.
On the other hand, don't go wild sending dozens of these briefs every month. Especially to the same reporters. That will put you in a negative position with them. Timely briefs are good, but can be difficult for a publisher or reporter to consider if the timing is not right for them. I suggest doing timely briefs, and have a few that are not subject to an economic situation, or a trend or something that might become dated too soon.


In the past 20 years there has been an abundance of research recognizing the importance of the therapeutic relationship as a predictor of outcome in psychotherapeutic work. In practice, couples seeking help often include those presenting with a recent history of domestic violence, infidelity, substance abuse, or other behavioral anomalies, manifested by one or both members of the dyad. In particular, where interpersonal violence is extant, clinicians often struggle with what to do with couples who want to remain together, and how to help them mitigate their potential to act out non-productively. The approach that is presented in this workshop is distinguished by its emphasis on the unmet relational needs behind maladaptive behaviors, rather than the behaviors themselves. This workshop will demonstrate possibilities for client engagement for couples who are difficult to work with, especially those with a history of interpersonal violence. This workshop will demonstrate when and how to work with "violent" or difficult to engage couples and how this approach can minimize client-therapist contextual resistance, improve the therapeutic alliance, promote couple safety and afford an opportunity for these clients to engage in more productive conversations and the realization of treatment goals.
Tom Caplan, MS, MA, MSW, MFT, PSW is a registered Social Worker (OTSTCFQ), licensed Psychotherapist (OPQ), Certified Marriage and Family Therapist (AAMFT), and a Certified Marriage and Family Therapy Supervisor (AAMFT). Tom is an Adjunct Professor at McGill University's School of Social Work and consultant to the McGill Domestic Violence Clinic. He is also a designated expert in Domestic Violence for the Quebec Court System. Tom does clinical work with forensic populations, is a consultant to the Caplan Therapy Centre and is the founder and consultant to the Montreal Anger Management Centre. Tom has published two books and numerous peer-reviewed journal articles on The Needs Acquisition and Behavior Change model (Needs ABC), which he developed. The Needs ABC model uses an integrated therapeutic approach that combines strategies also described in cognitive-behavioral, motivational, narrative and emotion-focused work. Tom has also participated in numerous research projects in collaboration with McGill University, Concordia University, the Jewish General Hospital and the Douglas Hospital.
Anyone working in the areas of domestic and family violence and abuse, sexual assault and abuse and bullying, trauma, and anyone interested in couples work.
This training will be valuable for, Counsellors, Victim Services, Social Workers, Psychologists, those who work domestic and/or family violence, or anyone that works with difficult couples.


Discerning drivers will appreciate the 2017 Toyota Highlander. Under the hood you'll find a 6 cylinder engine with more than 270 horsepower, and for added security, dynamic Stability Control supplements the drivetrain. Toyota prioritized comfort and style by including: front and rear reading lights, a trip computer, an outside temperature display, lane departure warning, cruise control, rear wipers, and power windows. Third row seats expand the maximum passenger capacity to 8. You and your passengers will enjoy the stereo system, which includes a CD player with MP3 capability, steering wheel mounted audio controls, and 6 speakers, enhancing the audio experience throughout the interior. Toyota also prioritized safety and security by including: dual front impact airbags with occupant sensing airbag, front side impact airbags, traction control, brake assist, ignition disabling, and 4 wheel disc brakes with ABS. When road conditions become unpredictable, rely on all wheel drive to maintain outstanding control. We know that you have high expectations, and we enjoy the challenge of meeting and exceeding them! Please don't hesitate to give us a call.


text:
Q: Display inline block causing a strange line to appear Here is my code: http://jsfiddle.net/spadez/qXZFW/10/
On the menu on the left it seems the display inline block is causing a line to appear at the start of each piece of text
.nav-sprite {
  background: url('http://www.otlayi.com/web_images/content/free-doc-type-sprite-icons.jpg');
display: inline-block;
background-repeat: no-repeat;
padding: 15px;
margin-right: 12px;
vertical-align: middle;
}

If I remove it, the layout changes and calls apart. Can anyone please explain why this is happening and how I resolve it.

A: Add text-decoration: none; to .nav li a - this will solve the problem. It's just the underlining of the link you see.

A: It happens because you are using an anchor tag by default has the property "text-decoration:underline", use the following rule to solve this.
.nav li a{
    text-decoration: none;
}

redpajama_set_name: RedPajamaStackExchange


Your octopus cash card is a proximity card. It works when it gets near to a reader/writer. We all have an octopus card. Some are personal cards linked to a credit card account, and some are standalone cards requiring periodic cash deposit updating. The news below reveals the real power of the card, and its network. This man with an octopus card, a standalone card, was tracked down by the police from the fare payment record of the bus which was linked to fare payment records of other public transport. His journey was mapped. Payment records of purchase in convenient stores and other shops were also tracked, thus a personal profile was created, including his area of movement, purchase habit, what he liked to eat, what he liked to buy. His face was then identified from CCTV record of the shops. I refer to myself that I use octopus card and credit card on all spendings. Cash is only used in taxi. My complete profile is available to those who would try to track me.
There are movies about the power of technology in tracking down information. Whenever someone used his credit card, CIA as well as hackers would immediately know his whereabout. Cars were installed with GPS device for security. The whereabout of the car was known worldwide to law enforcement agencies and hi-tech criminals. These are all known technologies. Now we have an octopus card for everyday use including tracking. With more powerful readers, which may already exist, our physical location may be tracked through the octopus card by the minute by numerous readers available everywhere.
The good news is that a city dweller can then totally integrate into the community and enjoy the services and security of a modern city. Criminals and terrorists can be monitored. The price is that we also offer ourselves to be monitored. While Hong Kong recently had a debate on street surveillance and stopped the police installing CCTV cameras in the streets, I read about the surveillance system in London where there are CCTV cameras in almost every street corner and public place. President Bush also admitted that the USA government read all internet mail, and he claimed it was legal.
Do you feel unsafe if there is no guardian angel watching you in the dark?


text:
Product Information Specifications for Hard Candy Below:
Legend (2015) (Blu-ray + Digital HD)
Major Crimes: Season 3
Jurassic Park Collection: Jurassic Park / The Lost World Jurassic Park / Jurassic Park III / Jurassic World [Blu-ray]
The Finest Hours [Blu-ray]
Manufacturer: Universal Studios Home Entertainment Brand: UNI DIST CORP. (MCA)
From Academy Award winner Brian Helgeland (L.A. Confidential) comes the true story of London's most notorious gangsters, twins Reggie and Ronnie Kray (Tom Hardy, Mad Max: Fury Road). As the brothers rise through the criminal underworld, Ronnie advances the family business with violence and intimidation while Reggie struggles to go legitimate for local girl Frances Shea (Emily Browning, Sucker Punch). In and out of prison, Ronnie's unpredictable tendencies and the slow disintegration of Reggie's marriage threaten to bring the brothers' empire tumbling to the ground.
Manufacturer: Warner Home Video Brand: Warner Manufacturing
Major Crimes: The Complete Third Season (DVD)Television's favorite squad of detectives is back on the case in the thrilling third season of Major Crimes, the powerful crime drama that ranks as one of basic cable's Top 10 original series. The elite team is back, headed by two-time Oscar® nominee Mary McDonnell as Los Angeles Police Captain Sharon Raydor, along with G.W. Bailey as Lieutenant Provenza, Tony Denison as Lieutenant Andy Flynn, Michael Paul Chan as Lieutenant Mike Tao, Raymond Cruz as Detective Julio Sanchez, Kearran Giovanni as Detective Amy Sykes, Phillip P. Keene as tech expert Buzz Watson, Jonathan Del Arco as Dr. Morales and Robert Gossett as Assistant Chief Russell Taylor. Plus, Graham Patrick Martin returns as Rusty Beck, the homeless teen and material witness taken in by Captain Raydor. The hit series shows law enforcement officers and prosecutors working together to score a conviction, with the team diving into some of the most captivating crimes.]]>
Manufacturer: Universal Studios Home Entertainment Brand: Universal Studios
Steven Spielberg returns to executive produce the long-awaited next installment of his groundbreaking Jurassic Park series, Jurassic World, an epic action-adventure.
Manufacturer: Walt Disney Studios Brand: Walt Disney Studios
Based on the extraordinary true story of the greatest smallboat rescue in Coast Guard history, THE FINEST HOURS is a tale of courage, loyalty and honor in the face of overwhelming odds. When a massive storm strikes off the coast of Cape Cod, it rips a T-2 oil tanker in half, trapping more than 30 sailors on its rapidly sinking stern. As Captain Bernie Webber (Chris Pine) and his crew set out in a 12-seat rescue boat to save them, Chief Engineer Ray Sybert (Casey Affleck) struggles to buy his men more time. Packed with heroic larger-than-life action and driven by the men's faith in their mission, themselves and one another, THE FINEST HOURS is a triumph.
Top Level Categories for Hard Candy.


Since 1944, the Ohio National Guard's 122nd Army Band has been a staple of the musical tradition of the United States military in Ohio. Members of the unit hail from every corner of Ohio (plus a few from other states) and are charged with carrying out the mission of strengthening troop morale and building a positive connection between the public and the Ohio National Guard.
As one of the finest National Guard bands in the nation, the 122nd utilizes its resources to perform dozens of missions each year across the state. Citizens, soldiers, and musicians alike all agree that the 122nd Army Band is one of the leading groups of its kind in the nation.


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Champions League: Teams and Their Countries
Champions League Overview
The Champions League is the ultimate soccer competition. Orchestrated by the Union of European Football Associations (UEFA), the Champions League pits the champions of domestic leagues and other qualifiers against one another in a grand annual tournament. Some of the most popular teams from the Premier League, La Liga, Bundesliga, Serie A, and Ligue 1 compete for eternal glory on the biggest stage.
Here's all you need to know to be the most well-versed "football" hipster now that the European version is the only kind available until August.
They Like to Score
No team has scored more goals in the history of the Champions League – rebranded as such from the European Cup in 1992 – than Real Madrid. The team has scored close to 900 goals in pursuit of European and Champions League honors. In their current campaign, the Madridistas count on the scoring power of Portuguese striker Cristiano Ronaldo and Welsh forward Gareth Bale.
German side Bayern Munich and Spanish side FC Barcelona both trail significantly behind the Galácticos of Real Madrid. They've each scored around 300 fewer goals in total, even equipped with strong players in their attacking roles. Robert Lewandowski and Thomas Müller help lead the line for the German giants, while MSN – Messi, Suárez, and Neymar – drive defenders crazy for Barça's benefit.
In fourth place, with close to 500 goals, is Manchester United, the highest-scoring English side and the only one in the top five spots. The team will have to wait another year for their chance to add to this tally, though, as the Red Devils failed to qualify for the Champions League due to their subpar performance last season.
Countries With the Biggest Trophy Cases
Between the European Cup and Champions League, Spanish clubs have produced the most success in winning the yearly competition. However, just two Spanish clubs share this success of over 16 titles: FC Barcelona and Real Madrid. While English clubs haven't seen the same volume of success that Spanish sides have, more teams have had a chance to wrap their collective hands around the trophy.
Liverpool (5 titles), Manchester United (3 titles), Nottingham Forest (2 titles), Aston Villa (1 title), and Chelsea (1 title) have all won either the European Cup or Champions League. In the 2017 campaign, Arsenal, Leicester City, and Manchester City are the three English sides with a chance to claim Champions League glory. If they could win the cup, it would be the first time for any of these clubs to earn such an honor.
Where Winners Are Born
In the first decade of the European Cup, Real Madrid claimed the top prize five times in a row. They then shared this honor with two Italian sides, AC Milan and Inter Milan, and one Portuguese side, Benfica. These were the only sides that won the right to be called European champions in the 1950s and early 1960s.
The 1970s saw the Spanish and Italian sides moved aside for teams hailing from England, Germany, and the Netherlands. There were also instances of back-to-back winners, with Ajax winning in '71, '72, and '73. Bayern Munich would win in '74, '75, and '76, while Liverpool would do a double in '77 and '78.
More recently, there has been a return to Spanish dominance, as Real Madrid and Barcelona have won the last three Champions League trophies.
Quest to Be the Best
Who will win the Champions League this year? Will it be a newcomer or a perennial favorite? Whichever team you're rooting for, show everyone where your allegiance lies with officially licensed merchandise and apparel from Fanatics.
AC Milan|Arsenal|Bayern Munich|Chelsea|FC Barcelona|Inter Milan|Liverpool|Manchester City|Manchester United|Real Madrid
The Best Gifts for World Soccer Fans!
The Greatest World Cup Teams, Players and Achievements in History


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'No, I'm right': Hawke wanted to wear his swimmers in revealing photo
By Glen Humphries
When you doorknock a former prime minister, you don't expect him to answer the door wearing nothing but a pair of swimmers.
Yet that's the sight that greeted reporter Lisa Carty and photographer Orlando Chiodo on New Year's Eve, 1994, when they knocked on the door where Bob Hawke was holidaying with his new love, biographer Blanche d'Alpuget.
Blanche d'Alpuget and Bob Hawke at a polo event.
The pair had been dating for some time but no one had managed to get a photo of them together.
On December 30, a friend of Carty's called to say Hawke and d'Alpuget were staying at a house at Berrara Beach, near Sussex Inlet.
The famous photo, taken on New Year's Eve in 1994, of Bob Hawke and Blanche d'Alpuget. Credit:Orlando Chiodo
They would walk along the beach every morning and evening, the friend said.
Without a chance to pick up a change of clothes or even a toothbrush, Carty and Chiodo jumped in the car and headed south.
That afternoon and the following morning, they staked out the beach near the house - trying to look inconspicuous sitting on the sand in their work clothes - but the couple didn't show.
Then Carty realised there was only one thing to do - walk up and knock on Hawke's door.
"He came to the door wearing nothing but his DPs [dick pokers, a type of swimwear], he didn't change or anything," Chiodo said.
"We explained who we were, where we were from. He was really good, he goes, 'okay, come back at one o'clock and I'll give you an interview'."
The former prime minister had one condition, that The Sydney Morning Herald were not to get a copy of the photo.
When they returned at the appointed hour, Hawke ushered them into the house - still wearing those DPs despite having had several hours to change.
"He opened the house to us, invited us in," Chiodo said.
"We interviewed him and Blanche about the book and what life had in store for them."
When it came time to take that now iconic photo, Chiodo took them out to the backyard - but not before asking the former prime minister if he wanted to change into something a little less revealing.
"No, I'm right," Hawke told him.
They had the photo the media had been after for months but, in the days of film photography, the drive back to the office was nerve-wracking.
"I kept thinking, 'what happens if there's nothing on that film'," Chiodo said.
"When we got back I ran straight into the studio at work and processed the film. There was the negative, as sharp as, a nice photo of Bob and Blanche, with Bob looking into her eyes."
The photo ran on the front page of the Illawarra Mercury the next day - on January 1, 1995 - and made waves around the world.
Chiodo said he had taken better photos, but none had the effect of the Bob and Blanche shot.
And of the man himself, Chiodo remembers Hawke as "a great man, so polite and humble".
"I didn't think it was going to be that easy," he said.
"I thought he'd say 'no, I don't want anything to do with you' and turn around and shut the door."
Illawarra Mercury
Blanche D'Alpuget
Bob Hawke


... a place of education where your child is genuinely loved and nurtured; safe and secure to revel in the challenge of lifelong learning! Penrith Christian School honours the privilege entrusted to educate the next generation – our leaders of tomorrow – and welcomes the opportunity to partner with you to equip, inspire and empower your child with foundations for life.
Penrith Christian School is a vibrant Preschool to Year 12 educational facility registered and accredited with the NSW Education Standards Authority (NESA). We are a distinctive Christian school with a four-tiered school structure unique to our region, reflecting the critical stages in the life of a child; Early Childhood Services, Junior School, Middle School and Senior School.


This course is suitable for anyone who delivers face to face training to others as part of their role. It aims to provide you with a basic training toolkit and will give you the opportunity to practice new skills in a safe and supportive environment. This can be run as a one day or as a two-day course.


That may be an understatement. Ever since human embryonic stem cells were first isolated 13 years ago, ACT (OTCBB: ACTC) has been laboring to capitalize on the cells' talent for transforming themselves into any tissue in the body. Over the years, Lanza and his colleagues have been blamed for everything from overconfidence to unethical science—the latter coming from conservative politicians who wanted to ban such research because the cells are derived from unborn embryos. But ACT charged ahead, raising money from hedge funds and other risk-hungry investors, and concentrating on using embryonic stem cells to regenerate retinal pigment epithelial (RPE) cells, which form a tissue that protects the eye's photoreceptors.
ACT was cleared by the FDA to test its RPE cells in two separate trials: one in patients suffering from Stargardt's macular dystrophy and the other in those with dry age-related macular degeneration (AMD). Stargardt's affects young people, and AMD strikes the elderly, but they are both marked by the degeneration of the RPE cell layer. And both are leading causes of blindness. ACT was the second company cleared by the FDA to test an embryonic stem cell-derived therapy, the first being Geron (NASDAQ: GERN), the Menlo Park, CA-based company that's testing its cells in patients with spinal cord injuries.
ACT's first two patients were treated at the David Geffen School of Medicine at UCLA, and are now being watched for six weeks to ensure the cells don't cause any dangerous side effects. Lanza explains that each trial will include 12 patients, and the doses will escalate over time. If no adverse events are observed in the first set of patients—who will receive the smallest dose of 50,000 RPE cells—the next set of patients will receive 100,000 cells. Then they'll be observed, and so on, until the highest dose of 200,000 cells is reached.
Advance cell technology more popular.
I have dry ARMD and am losing my vision. I would be eager to participate in further trials.
I have wet macular degeneration in my right eye and would jump at the chance to be included in this trial.
HO UNA RETINITE MIOPICA,E' POSSIBILE ACCEDERE ALLA SPERIMENTAZIONE.GLI ESAMI CHE RICHIEDETE POSSO FARLI A PALERMO O LI DEVO FARE FARE IN OSPEDALE DA VOI?
I've had myopic degeneration since 35 years old.I am now 63. Right eye considered blind. Left eye now having problems. I am more than willing to particapate in trials. Live in Spring Hill, Florida but will travel.


Condensation of the gas above the process liquid slowly causes the low side of the transmitter piping to fill with liquid. The pipe is therefore purposely filled with a convenient reference fluid to eliminate this potential error. This is called a wet leg condition.
In a wet leg application, the low pressure side of the level transmitter will always experience a higher pressure than the high pressure side. This type of installation requires that the height of the wet leg will always be equal to or greater than the maximum height of the liquid column (H) inside the tank.
As can be seen, the differential pressure, ΔP, sensed by the transmitter is always a negative number (i.e. low pressure side is at a higher pressure than high pressure side) since in this application, Y is always greater than (H + X) and S.G2 is equal to or greater than S.G1. To properly calibrate this transmitter, a positive bias of (S.G2 * Y – S.G1 * X) is needed to elevate the transmitter output. This calibration technique is called Zero Elevation.
Want to go back to previous sections on Level Measurement?


Elexio Community is a resource for our Grace Family to connect with one another, engage with events and opportunities and manage your online giving. With a fresh new look, Elexio Communiy makes it easier than ever to get in touch with other church members, view the church calendar and sign up for ucoming events, and manage your profile.
If you do not currently have an Elexio account and would like one, press the button below to send us a request form. We will create the account for you and send you your login information via the email you provide.
If you already had an Elexio account with our old system then your login information was carried over to the new system. If you are having trouble logging in, try using the Forgot Password feature or watch our How-To-Videos. Your username should be your primary email address. If you can't remember your username or if you used a different email address, then contact the church office.
We also have an app that is designed for smartphones and tablets! This will be helpful for having quick access to the directory, calendar, and giving.
Personally edit your contact information, check out our online directory, manage your online giving, and also view and sign up for upcoming events. Please note that each individual logging in will need their own unique email.
Basic information (phone, email, address, birthday) added to your profile will be viewable on the Grace Baptist Church directory. Anybody with a Grace Baptist Church Elexio account will be able to view this information.
What if I Don't Want My Contact Information to be Listed?
We completely understand if you would prefer to not have your personal info available in the directory. If you'd like to use Elexio Community, but prefer your info stays private, you can contact our office or click the button below and we will remove your contact information from the directory.
Simply tap on the word "domain" and replace it with gbcbowie. In the end, that field will read "gbcbowie.elexiochms.com"
For help, contact our office!
This is the Giving Portal. This will use your Elexio Giving account - which is a different login than your Elexio Community account. The first time you login to the Giving Portal, you will need to hit Forgot Password. Enter the email that's associated with your Elexio Community account. You will then be sent instructions on how to make a new password.
You cannot actually give through Elexio Community. You will need to go through the Giving Portal or give on the Elexio App. With an Elexio Community account you will be able to view your giving history and print your giving report at your convenience.
Simply open the app and log in. Then tap on the Give button. Follow the app's instructions from there to make your donation.


The Melbourne Business School Doctoral Program in Finance has the largest and most well-developed set of doctoral subjects on offer in Australia. Taught by the Department of Finance, which is internationally recognised for its world-class research and research training and augmented by visitors from the world's top finance programs.
The Doctoral Program consists of a Master of Commerce coursework program followed by a PhD.
All successful applicants will be fully-funded with a scholarship for the duration of their doctoral program.
Graduate Research candidates are provided with funding and encouraged to submit papers to prominent local and international finance journals and conferences. Students are also encouraged to apply for tutoring positions within the Department throughout their candidature.


Culverhill School - Culverhill's Christmas Fayre is Coming Up!
Culverhill's Christmas Fayre is Coming Up!
The ever popular Culverhill Christmas Fayre is almost here! Join us on Thursday the 6th of December for festive fun!


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Petals last won the day on August 8 2013
Petals had the most liked content!
About Petals
Slean Wolfhead
Viee
NorthumbrianDavid
Moving to Melbourne Patterson Lakes ?.
Petals replied to Aggi's topic in Victoria
The plant at Carrum is not a water works its a sewerage plant and my late husband worked there for 30 years. It does pong when the wind gets up at times and depends where you live around there. Its a huge plant and takes all the sewerage for most of Melbourne below the Yarra River. I found on the freeway sometimes the Gathercoles slaughter house smelt too of chlorine type smell. I live on the Mornington Peninsula and that was fine for us as only a short run for my husband to get to work. Patterson Lakes can be very windy before we moved to the Peninsula we lived in Edithvale and we found that it was quite windy as its very flat around there.
Moving to Melbourne
Petals replied to kelv's topic in Victoria
Getting accommodation with animals can be a little harder, they have laws that allow you to have pets but its the landlord who makes the final decision. Also dogs are not as free here as they are in the UK, they are not allowed in pubs or shops or on transport unless they are guide dogs. In the summer they can go to the beach before 9am and after dark in the evening but on a lead unless the beach is leash free. There are dog parks around though where people take their dogs to exercise etc. Houses are more expensive to rent than apartments. Have a look on realestate.com.au for rental in areas such as Port Melbourne, South Melbourne, Prahran, St Kilda Elwood these areas are handy for Port Melbourne. Also look at the public transport site for Melbourne and follow the Frankston line out as it runs along the beach if you want beach.
Aldi to sell alcohol in store
Petals replied to newjez's topic in Aussie Chat
Come live in Victoria we do not have all these trading restrictions and never have had .
Issues with Air BnB Neighbours
Petals replied to ADAVIDH's topic in Aussie Chat
Seems this is something we have to put up with. Anywhere with tourist potential has these properties. On the Mornington Peninsula here in Victoria there are many disgruntled retirees who complain to the paper and the council etc. Also blocks of units, it might look nice to downsize into the city into a nice unit, only to find that most of the units are air bnbs these days. Its a modern problem and what is the answer. Move to acreage at least they are not right next door, of course that is not possible for most people. Its just a shame that these days people do not respect other people and have no consideration.
Breaking News - 457 Visas Stopped
Petals replied to The Pom Queen's topic in Visa Chat
I am pleased this has happened. I am sorry for those of my compatriots who want to use this visa but its not good for Australia. Its not good for a lot of people who have this visa. I see weeping, moaning etc in the news about how we cannot survive without this visa and then I think on. My daughter two degrees on low pay, why because she got ill and had to take 2 years out of work. So hard to get back into a job. We used tor train people in Australia, take then from uni or TAFE and give them a go, but with this visa it stopped. Everyone wants experience. So you are a migrant you come here you bring up your family and then you find that even if they are educated its hard for them to get a job, experience, well where do the people get the experience who come here on these visas. In their own country that still trains people. Getting a degree, diploma shows that you are able to have stickability. However people only start to learn when someone give them a go despite the weight of education behind it. So good lets train those many many graduates and young people wanting a trade.
457 abolished
Petals replied to sunshinedawn's topic in Victoria
Its not a bad wage a lot of people earn a lot less but being Australians they can manage on less as they have family etc. Probably both have to work, rents are expensive for good property unless you go to the fringe of the city. Then you have the added burden of commuting and paying to get to work. Melbourne is a huge place with four million people so you can live a long way away from where you work. Not like UK in distances at all. We think nothing of driving for an hour to get somewhere in Melbourne. As the wage includes super then you will have less than 85000. Have a look on realestate.com.au at property rentals this should give you some idea. A lot of Brits are moving to the western areas of Melbourne as the housing is new and more affordable. Point Cook, Tarneit etc. Cranbourne in the south East is also cheaper. All fringe areas.
Sydney............ What a disappointment!!
Petals replied to MissionMelbourne's topic in Aussie Chat
I lived in Sydney for a few years and then moved to Melbourne. Melbourne is not as scenic and the centre can be described as bricks and mortar dull. However there is no comparison to the lifestyle. I was single then and when my friends and i moved to Melbourne it was so much easier to get somewhere to live. The places we had lived in Sydney at the time, Neutral Bay, McMahons Point had been furnished apartments. Much more choice in Melbourne. Still here after all this time and still think its the best place to live out of the larger cities. I will probably move at some stage but it will be up to the Murray or somewhere like that, somewhere where I can get back to Melbourne.
Are There Any Nursing Jobs?
Petals replied to Phoenix16's topic in Aussie Chat
Sign of the times, its not just nurses, its teachers, it specialists, lawyers, business degrees, etc. There is an over supply as more and more young people go to university. A degree is now requested to do anything. The real winners are the young who have been able to get a trade apprenticeship. Unfortunately where once it was very easy to get a trade apprenticeship, this is no longer the case due to the changes in work place management. Businesses no longer want to take on expense of training people and expect everyone to have experience. When the government was in charge of the electricity, gas, water, trains and other public entities, many young people were taken on as apprentices. This all stopped with the selling up and shake up and down sizing of government and putting into the hands of the private world. Now we have 17% youth unemployment where I live. Graduates are finding that its difficult to get a job without experience and no business wants to give them the opportunity to get it. Teachers all on contracts, nurses in banks, employed to be on the ward you stay on, no moving around for experience these days. Doom and gloom yes it is, the only way it will change is if they stop this stupid idea that trickle down works. It works flowing upwards but there is no downhill with money. To the OP you have a degree but now you need to add to it, a masters a phd, or some diploma that is what is happening now to get the edge. Also the debt that students owe will never be repaid. My daughter has two degrees and through no fault of her own she became ill and had to take 2 years out of work to recover and she has never made it up. She owes a lot of money in hecs and looking like it will never get repaid. All this came about from people who had free education.
Harry's dad is seriously ill
Petals replied to newjez's topic in Chewing the fat
I know its in the papers etc but quite honestly I find the whole idea of questioning anyone's paternity in the press or on social media quite abhorrent. It does not matter whether one is rich, poor, royal or whatever its very very hurtful. How would I feel, well I would feel pretty damned upset etc especially if people kept raising the question year after year.
New Foreign Worker Levy - applies to partner visas?
Petals replied to tylerolo's topic in Temporary Visas
Its ok wanting to get skilled workers,however we have a glut of graduates and under employed people here in Australia desperately wanting to get experience and a job. Any measure that will assist Australians to get work is good. Maybe its not good for people on here at present, however if you come and get permanent residence, bring up your family here, educate your family here, do you not want them to be able to get experience and a job. With all the skill importation its driving ordinary young Australians out of the work force. 17% unemployment here on the Mornington Peninsula. Also so many people under employed and they are not mentioned in figures.
Melbourne - Victoria- the good, the bad, the ugly
Petals replied to Fosh's topic in Victoria
I have lived in Sydney and Melbourne and much prefer Melbourne. Its the lifestyle that is so good, there is something for everyone and every interest and sport. All are catered for. I have lived in Balaclava, Elwood, Caulfield, Edithvale and the Mornington Peninsula and I love all the places I have lived. 30 years in this house and, yep its got busier but that is because there are 2 million more people here than there were in the 80's. People in Australia move to Melbourne for the lifestyle.
They are wanting to stop the visa leading to permanent residence. It will be well accepted by many Australians looking for work.
Petals replied to Beffers's topic in Health
We paid the higher levy it was still cheaper that way. Check on that because they have or are changing it now so that people would stop taking out junk health care and using the public system.
However if you do not use your health insurance count up the cash you spend over the years, its a lot more than waiting until you actually need the private system i e older and needing joints etc. We dropped ours for along time and we did not take up the lifetime system when it came in, why because we felt as though a gun was over our head and we did not like the way it was done. Anyway I took out health insurance when I needed my knee replaced and I have it now and I have to pay the loading but goodness me its a drop in the ocean to what we would have paid, paying in case. If you are hurt at work or in a car you are covered anyway, if you have an emergency, they do not take you to a private hospital they take you to a public one. Private likes us oldies, not much trouble. If we have a really serious problem in a private hospital they move us to the public. They did that to my Dad, one day in private had an op and they said we cannot look after you here, you have to in the public hospital. He did and my mum got bills for gap fees for months from the public hospital.
Child's pre existing medical condition - how does it work for permanent residents?
Petals replied to sns's topic in Health
Pensioners and low income people have a health care card and they are entitled to a free gov type hearing aids every three years. Also they get their attendances paid for by medicare. Most ancillary medical is in private hands these days. The gov does handle at hospitals etc and your daughter may be referred by a doctor to a hearing clinic, depending on the condition. People take out health insurance extras but personally I think you pay more than you get in the long run. The health system is very good with children with any sort of condition. I can only speak for myself as my daughter became a type 1 diabetic at 11 and was looked after in the health care system very well. In fact she was in an adolescent clinic until she turned 25. Prescriptions are not free here and average about 32 dollars per scrip per month unless pensioner or health care card holder. Not all our doctors bulk bill, some do, at my clinic the present rate for an appointment is $70.00 and we get $36.00 approx back from medicare. There are a lot of bulk billing doctors around though, then you do not have to pay. If her specialists think it may rectify itself, why not wait until the time comes. Do not fear the medical system, I actually prefer it as we have a choice of doctor, we can go to who we like. Choice of specialist usually by your local GP and no zoned hospital type system.


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Home » Customer success
Customer Publications March 2022
We at Golden Helix thoroughly enjoy seeing our software being utilized to solve problems and assist in the diagnosis of hereditary diseases. It is gratifying to be notified of customer publications in which they are doing precisely this. While there have been numerous publications this month showcasing Golden Helix software being applied, below are a few that stuck out specifically. The following all utilized our flagship software, VarSeq. VarSeq is a multi-tool for data analysis and allows for scalability, intuitive & repeatable workflows, and user friendliness. Our customers especially appreciate the ease of functionality and automated components for variant classification. So please continue reading to learn of a few examples of the VarSeq suite out in action and how it can help you with your data analysis!
Non-conventional Genetic Basis of Congenital Adrenal Hypoplasia in South Asia
Congenital adrenal hypoplasia or adrenal hypoplasia congenita (AHC) is a rare disorder ascribed to mutations in three genes, namely, the dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene 1 (DAX-1/NROB1 gene), steroidogenic factor-1 gene (SF-1/NR5A1 gene), and Achalasia-Addisonianism-Alacrima syndrome gene (AAAS gene). Five cases of AHC of local South Asian origin are described here. Golden Helix VarSeq 2.2.0 (Golden Helix Inc., Bozeman, MT, United States), the clinical genomics interpretation and reporting platform, was used for genetic study. No subject had congenital adrenal hyperplasia (CAH). Four male neonates presented with hypoglycemia, and one older female child presented with hyperpigmentation. This girl had a recognized mutation in the AAAS gene, while none of the four male neonates had any of the recognized mutations associated with AHC. Further, none were salt-losing, which is the conventional Western phenotype. Thus, additional, yet unknown, gene(s) must be operative in AHC among South Asian subsets.
Chatterjee S, Majumder A (March 26, 2022) Non-conventional Genetic Basis of Congenital Adrenal Hypoplasia in South Asia. Cureus 14(3): e23527. doi:10.7759/cureus.23527
Whole genome sequencing identifies rare genetic variants in familial pancreatic cancer patients
Pancreatic ductal adenocarcinoma (PDAC) represents one of the most lethal malignancies with very high mortality and short survival time. About 5–10% of the PDAC patients have a familial predisposition to the disease designated as familial pancreatic cancer (FPC), suggesting genetic modulation of FPC pathogenesis. It is estimated that currently identified sequence variants account for less than 20% of the genetic basis of FPC leaving the majority of the genetic architecture unclarified. We performed whole genome sequencing (WGS) analysis on benign formalin-fixed paraffin-embedded (FFPE) tissues from 35 FPC patients focusing on genes enriched by rare and functional sequence variants. We identified 40 genes hosting at least 2 protein truncating variants (PTVs). Significant overlaps of the 40 genes were found (p < 1 × 10–22) with cancer genes, cancer driver genes and genes found in previous studies on cancer, including ATM, POLE, BRCA2, TYR03, PABPC1 and SSC5D. The PTV genes are significantly overrepresented in biological pathways in cancer development and progression including extracellular matrix organization, signaling by RHO GTPases and RHO GTPase cycle. Association analysis using external controls detected 6 genes with p < 0.05. The WGS analysis revealed high heterogeneity in the detected rare variants among FPC patients and provides novel genes harboring potential mutational hotspots for future validation and replication.
Tan, M., Brusgaard, K., Gerdes, A-M., Larsen, M. J., Mortensen, M. B., Detlefsen, S., de Muckadell, O. B. S., & Joergensen, M. T. (2022). Whole genome sequencing identifies rare genetic variants in familial pancreatic cancer patients. Annals of Human Genetics, 1–12. https://doi.org/10.1111/ahg.12464
Complex Autism Spectrum Disorder with Epilepsy, Strabismus and Self-Injurious Behaviors in a Patient with a De Novo Heterozygous POLR2A Variant
Autism spectrum disorder (ASD) describes a complex and heterogenous group of neurodevelopmental disorders. Whole genome sequencing continues to shed light on the multifactorial etiology of ASD. Dysregulated transcriptional pathways have been implicated in neurodevelopmental disorders. Emerging evidence suggests that de novo POLR2A variants cause a newly described phenotype called 'Neurodevelopmental Disorder with Hypotonia and Variable Intellectual and Behavioral Abnormalities' (NEDHIB). The variable phenotype manifests with a spectrum of features; primarily early onset hypotonia and delay in developmental milestones. In this study, we investigate a patient with complex ASD involving epilepsy and strabismus. Whole genome sequencing of the proband–parent trio uncovered a novel de novo POLR2A variant (c.1367T>C, p. Val456Ala) in the proband. The variant appears deleterious according to in silico tools. We describe the phenotype in our patient, who is now 31 years old, draw connections between the previously reported phenotypes and further delineate this emerging neurodevelopmental phenotype. This study sheds new insights into this neurodevelopmental disorder, and more broadly, the genetic etiology of ASD.
Evans, D.R.; Qiao, Y.; Trost, B.; Calli, K.; Martell, S.; Jones, S.J.M.; Scherer, S.W.; Lewis, M.E.S. Complex Autism Spectrum Disorder with Epilepsy, Strabismus and Self-Injurious Behaviors in a Patient with a De Novo Heterozygous POLR2A Variant. Genes 2022, 13, 470. https://doi.org/10.3390/genes13030470
Customer success Customer Publications, Golden Helix, VarSeq
About Casey Fullem
Casey Fullem, Marketing Coordinator at Golden Helix, joined team in October of 2021. He is an analytics driven digital marketer that values tactile marketing efforts that yield return. Building a cohesive brand and executing performative marketing campaigns is his passion, alongside the slew of outdoor activities that Bozeman has to offer. Casey is largely passionate about skiing, rock climbing, whitewater kayaking and rafting, fly fishing, backpacking, and other outdoor activities that excite.
View all posts by Casey Fullem →
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What's up babes, these pictures were taken at the awesome 3643 St. Laurent Apt. 200. I decided to wear a denim vest under my V-neck rather than a simple blouse to add my own touch to the look. If you don't already know, I'm completely in love with denim and wear it everyday if possible. I'm off to do some studying.
Hope everyone's week started on the right foot yesterday!
Thank you so much for following & reading, means the world to me.


Ambrose Recruitment will reward you with Amazon vouchers up to the value of £500 for a secure placement made from a recommendation you give us.
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