text:
Q: Python requests timeout in AWS Lambda Python requests is timing out from AWS Lambda for below url's.
https://www.nseindia.com/get-quotes/derivatives?symbol=NIFTY
https://www.nseindia.com/api/option-chain-indices?symbol=NIFTY
And its working for other urls.
Working url - https://support.oneskyapp.com/hc/en-us/article_attachments/202761627/example_1.json
Below is the code I am using.
import requests

def lambda_handler(event, lambda_context):
    headers = {"User-Agent":'Mozilla/5.0 (Windows NT 10.0; Win64; x64) AppleWebKit/537.36 (KHTML, like Gecko) Chrome/78.0.3904.87 Safari/537.36'}

    with requests.session() as rq:
        print("Loading cookies")
        rq.get("https://www.nseindia.com/get-quotes/derivatives?symbol=NIFTY", headers=headers)

        print("Execute get request")
        result = rq.get("https://www.nseindia.com/api/option-chain-indices?symbol=NIFTY", headers=headers)

My Lambda is using Python3.7 runtime, not associated with any VPC and timeout is set to 1 minute. I tried with Lambda execution timeout of 5 minutes still no luck.
Output

Response: {   "errorMessage": "2020-11-17T04:58:34.039Z
0f69a07d-6139-4aab-b1cf-310b19243735 Task timed out after 60.06
seconds" }
Request ID: "0f69a07d-6139-4aab-b1cf-310b19243735"
Function logs: START RequestId: 0f69a07d-6139-4aab-b1cf-310b19243735
Version: $LATEST Starting request session... Loading cookies END
RequestId: 0f69a07d-6139-4aab-b1cf-310b19243735 REPORT RequestId:
0f69a07d-6139-4aab-b1cf-310b19243735  Duration: 60060.48 ms   Billed
Duration: 60000 ms    Memory Size: 128 MB Max Memory Used: 59 MB  Init
Duration: 383.95 ms    2020-11-17T04:58:34.039Z
0f69a07d-6139-4aab-b1cf-310b19243735 Task timed out after 60.06
seconds

I am guessing this would be related to User-Agent headers. Any help would be highly appreciated.

A: It could be that https://www.nseindia.com/ is blocking AWS IPs because they don't want to be scraped?
This is what I got when trying to open it from one of my EC2 machines
[ec2-user@ip-10-2-120-90 ~]$ curl https://www.nseindia.com/get-quotes/derivatives?symbol=NIFTY

<TITLE>Access Denied</TITLE>

Access Denied

You don't have permission to access "http://www.nseindia.com/get-quotes/derivatives?" on this server.

Reference #18.d6d3dead.1605602802.2598bb12

redpajama_set_name: RedPajamaStackExchange


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Award-winning choral conductor and Queens College alum Harold Rosenbaum made his mark as a 23-year-old leading his first choral group in performance at Carnegie Hall. The debut of the young maestro received rave reviews in the New York Times.
While he was associate conductor of a Queens College choir and completing his master's degree, "I realized I needed to start my own chorus, to have my own instrument," recalls Harold Rosenbaum '72, '74 MA. Shortly after graduation, he advertised for amateur singers for his new chamber choir, the Canticum Novum Singers, now entering year 39 of presenting early music and works from other periods. Renting Carnegie Recital Hall for their first concert "was brazen for a 23-year-old," he realizes. From that first New York Times rave review in 1973 has risen a crescendo of acclaim.
With his baton, Rosenbaum leads both renowned soloists and amateurs up dizzying choral heights. Over four decades, he has sounded these high notes: choral conductor with 450-plus world premières and more than 1,500 concerts . . . founder of six choral groups . . . currently associate professor of music at the University of Buffalo . . . faculty member at his alma mater (1972-1998) . . . taught at the Juilliard School . . . namesake of the choral music series of the world's largest music publisher, G. Schirmer Music . . . longtime organist and choir director at St. Luke's Episcopal Church in Katonah, New York.
Contemporary choral composers—from the sadly neglected to prizewinners—find in Rosenbaum and his New York Virtuoso Singers the finest of friends. This professional chamber choir, which he founded in 1988, is undaunted by their most complex compositions.
Remaining at QC for a master's in choral conducting, he organized a prep chorus. No one expected it to give concerts. With ecumenical enthusiasm, the grad student brought together the QC Preparatory Choir, Transfiguration Lutheran Church Choir of Harlem, and Westchester Jewish Choral Society (which he also founded). Not on campus. In Carnegie Hall. And to perform Haydn's Creation.
His bio doesn't even mention the 75 high school clinics he has given. "I'm very parental. I love passing on wisdom and guidance to the young," he says warmly. He and his wife, Edie, have two daughters and two grandchildren.
Hidden talent: Drawing. Two from his teenage days—of his father, a musician, and a colored pencil copy of Rubens's The Lion Hunt—hang on his wall.


text:
Angel City Lumber was created in 2015 by Jeff Perry and Charles DeRosa. It was Jeff's big heart that led him to wonder why Los Angeles couldn't be reusing all the trees it was cutting down. It was his big mouth that roped Charles into joining him on this mission. And it was their combined naiveté that led to a 10,000 sq ft warehouse in Boyle Heights full of slabs and boards made from Los Angeles trees.
We officially opened for business in 2017. Since then, we've seen a powerful reaction to urban lumber in Los Angeles. We have a growing team of craftspeople, wood workers and environmental experts, all of them excited by the prospect of reusing as many Los Angeles trees as possible.
The people (and cat) of Angel City lumber
Todd's background as a producer (sort of), director (there was that one time) and actor (really?) led him to work for Apple and discover his true passion for logistics, systems and organization. Todd has transformed Angel City Lumber from a few piles of disheveled wood into the smooth running operation it now is.
Recovery Manager
Vincent heads up our tree recovery department. Regularly tasked with the (very) difficult job of recovering 8,000 lb logs from backyards, construction sites and highway medians around Los Angeles. But don't let Vincent's cool demeanor fool you, he's got a burning, desperate, passionate love for pulling heavy logs behind a 1997 Dodge 3500.
After ten years of working in the film business, Charles made the natural decision to join Jeff Perry in opening an urban lumber yard in Los Angeles. Since then he has taught himself human resources, payroll and workers compensation. He is no fun to talk to at cocktail parties.
Urban Lumber Consultant
On paper Brady, our in house business development and sustainability expert, looks pretty good. An engineer with a resume chock full of work in sustainable consulting, energy conservation and building services, Brady's skill set is invaluable to Angel City Lumber. But don't be deceived, even with all those brains, he's a woodworker at heart - and we all know what that means!
Mill Works
Shayna discovered woodworking cutting animal shapes in her uncle's garage when she was six. Now in charge of our mill works department, Shayna keeps the jointer and planer busy, though her trusty hand plane is never far from her side.
Head Sawyer
Matt brings the organization, dependability and resourcefulness of a fire fighter (from his previous career) to his role as head sawyer. It was his simple and overwhelming love for cutting things that landed him at Angel City Lumber. As he said in his job interview "there's nothing I love more than cutting things up"
The closest thing to a renaissance man Boston is likely to produce, please give it up for Jeff, the Zen master of Los Angeles urban lumber! With a burning (slightly itchy) love for making LA a better place for his kids to live, Jeff is a mere whisker away from attaining full urban lumber enlightenment - if only he would stop mixing up his globulus Eucalyptus with his camaldulensis.
Robles
Shop Cat
Shop cat extraordinaire, Robles was a stray found amongst some oak logs at Angel City Lumber. She prefers salmon over tuna, pets over naps, and she likes her 8/4 sycamore sanded to 220, at the least!!

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Kogama: West Town
Kogama: West Town belongs to Multiplayer and it is often associated with Gun Games and Survival Games. This game has received 1704 votes, 1524 positive ones and 180 negative ones and has an average score of 4.4.
It is a game played in landscape and it's playable on Desktop on www.gamepix.com. This game has been published on 2021-05-28 and updated on 2021-05-28.
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Is there a way to track visitors to a publicly visible page?
If a page is available for Viewing for anonymous users, is there a way to track the visitors to that page?
Is there an ability to see who has visited a page and how many times?
Another option would be to use Google Analytics.


text:
import React from 'react';
import PropTypes from 'prop-types';
import { FormattedMessage } from 'react-intl';
import ValueListCell from './ValueListCell';

export default function ClusterFactCheckedByTeamsCell({ projectMedia }) {
  const values = Object.values(projectMedia.cluster.fact_checked_by_team_names);
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    <ValueListCell
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      noValueLabel={
        <FormattedMessage id="checkedByTeamsCell.noFactCheck" defaultMessage="No fact-check" description="Table cell displayed on feed page when claim is not fact-checked yet" />
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  projectMedia: PropTypes.shape({
    cluster: PropTypes.shape({
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text:
Digesting some Spurs statistics: has Tottenham's luck run out?
Jasmine Baba digs deep into the statistics behind Tottenham's recent form. After their winning streak ended at the weekend, a closer look at the numbers reveals that Spurs should brace themselves for an incoming dip in results…
Tottenham were defeated 2-1 by London rivals Chelsea in Saturday's early kick-off. It wasn't a surprising result, especially to most Spurs fans. Although they had enjoyed three wins on the bounce prior to Saturday, something hadn't felt quite right.
The start of this winning run came after a torrid Christmas period: losing at home to Frank Lampard's side and, although winning at home to Brighton, following up with a draw away to Norwich, defeats against Southampton and Liverpool, and another draw against Watford. Winless in four games, Spurs managed to scrape past Norwich in a match that kicked off this good bit of form. José Mourinho started to grind out wins.
But there's a problem when statistics don't back up victories. Quite frankly, Tottenham have been riding on luck. And here's how.
Tottenham 2-1 Norwich
The first of the winning run came against rock-bottom club Norwich. Relegation-fodder should basically be swept aside by clubs trying to make the Top Four — but the Canaries did beat defending champions Manchester City, so maybe deserve a little more respect.
Although Mourinho's men created the better of chances here (Expected Goals 2.22 – 1.36), the visitors kept the pressure up and shared equal amounts of possession, having two shots on goal compared to Tottenham's three. However, the only goal for Norwich was their penalty: not from open play. In the end, although closer in quality than the league table suggests, Spurs were right to win this one.
Tottenham 2-0 Manchester City
Strange as it sounds, Spurs got hammered in their second win.
On a fundamental level, the home side only had 33% possession, and only three shots which were all on target. Compare this to all the possession the visitors had — plus the fact that five shots out of their 18 were on target — and you wouldn't expect the match to end on a 2-0 scoreline. At an xG level it's even worse; by half-time Tottenham had created nothing (xG 0-1.67) and at the final whistle it was still an astounding 0.43-3.23 in City's favour.
Fortunately for Spurs, the defending champions had missed a penalty to keep it all-square, and their luck increased when Oleksandr Zinchenko was sent off. City going down to 10 men was another pivotal moment, with Tottenham taking advantage of having an extra man, scoring just three minutes after Zinchenko's dismissal. Lady luck had Mourinho on her cards.
Aston Villa 2-3 Tottenham
This match was a tale of two halves. It was rather even in the first 45 minutes in terms of chances: two shots on goal against three, an xG of 0.88-1.30, but Aston Villa had more of the possession. In the second half, the hosts evened things up to make it 2-2, but the away team, for once, was truly dominant. Seven shots on target proceeded for Spurs, and an xG of 1.68-3.72 at the end of the 90 minutes.
But stats don't tell you everything.
The match remained at 2-2 until deep into injury time and, as luck would have it, Villa's Bjorn Engels mis-kicked the ball into Heung-Min Son's path to score the winner. Yes, Spurs deserved to win, but not in the way they did.
There are alarming underlying stats in both Tottenham's wins and their losses. They have conceded at least two goals in 10 Premier League away games this season, which hasn't occurred since the 2008/09 season campaign, when it happened 11 times.
On top of this, their on-the-road form is woeful: they are 11th place in the table in terms of away results. If you dig deeper into xG statistics, and project these stats into Spurs's league position on Expected Goals For v Expected Goals Against, they'd be 12th. Luck is running out for Tottenham. Without Son or Harry Kane, expect their form to worsen.
Follow Jasmine on Twitter @_BabsJ
Jasmine Baba
1 Comment on Digesting some Spurs statistics: has Tottenham's luck run out?
c b waters // February 26, 2020 at 1:25 pm // Reply
Our football has, frankly, been horrible since the CL final, and it wasn't great during that match either, because Liverpool were certainly well below par, and it was either team's match. Subsequently Poch didn't help his cause with ever stranger and frustrating comments, and although I don't blame Mourinho since arriving, I wish he'd been braver in games, even with Sissoko, Kane and then Son receiving long term, team wrecking, injuries.
Our planning and buying/replacing players in the last two years has been appalling!
We're massively imbalanced now while remaining key squad players are playing like strangers in a strange land, with new and 'strange' tactics. I wouldn't have too much of a problem with Mourinho 'shutting up shop', if that particular tactic even worked!! But it doesn't (work), because Verts and Toby are ageing and aren't the players they were, while Sanchez, Foyth, Dier and, of course, Wanyama, have regressed, and the full backs are mediocre. So if I blame anyone in the last few years, I blame Levy. I don't say that lightly because he delivered a fabulous stadium, a wonderful training facility, and did spend money.
But he's not as 'slick' a dealer as he was. Llorente should have come back if we couldn't get anyone to cover Kane. But I don't believe that there wasn't a top striker out there this January willing to to take up the challenge, and join Tottenham. The Eriksen debacle carried on far too long, and we lost a lot of transfer money because of it; the Alderweireld long -term contract situation distracted everyone too (until Toby realised no other top club was coming in for him, so stayed); the Dembele loss was never ever addressed; and the full back situation was disgraceful (Walker going a season too early, Rose a season too late, and Trippier shouldn't have left at all) and look at the 'replacements' in those areas! Lo Celso could prove a great buy and a hopeful replacement for Eriksen, IF he's played in the right position, but what sort of player is Ndombele? I catch glimpses of huge promise, but he has a capacity for not being fully fit, and giving in to minor injuries, and what does he do within a team framework? Is he a DM, a CM, or an attacking midfielder? We do not need the most expensive signing in Spurs history to be a 'utility' or 'impact' player, whose best position is unknown! Ndombele is symptomatic of the loss of our 'team' where all key players should be playing in their 'best' position, and linking with others in THEIR best position. And if someone is injured it should be reasonable to expect decent cover (for each position) stepping in! No wonder Alli is lost! Having once played in a world class axis of himself, Eriksen and Kane, ably supported by Son, no one playing with Alli now has the football brain to understand what he's trying to do! Lamela, Moura, Berjwyn are all excellent players but they need good 'team' players in their specific positions around them, otherwise they look like a jumbled up mess! Horrible to see this mess against Leipzig and Chelsea. If we'd been braver we may have lost by more in those games, but at least we'd have been providing better eye appeal! It really isn't that long since we were beating much better Chelsea teams, while Dortmund (who have been better and more consistent than Leipzig) was in the last couple of years our 'rabbit' opponent! Carry on like this and we'll be staring at mid-table at the end of the season, and certainly with no FA Cup (as though it were a guarantee for Jose' this season anyway!?). We may well end up with no European football at all, and then who could Jose' and Levy target in the summer, let alone 'keep'? Two years ago we were on a par with Liverpool. Over the past 15 months they've soared, while we've gradually declined, and now more recently, 'plummeted'! We should be 'tweaking' NOT rebuilding from scratch!


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Washington DC Real Estate News
Milt Peterson: 50 Years and 120 Projects
Washington DC View count:
September 1, 2015 Ethan Rothstein, Bisnow Deputy Managing Editor
This week, Milt Peterson celebrates 50 years of the company he started in 1965. "When you start from nothing, it's so hard, but fun, to grow," he told us yesterday from his vacation home in Maine.
Peterson Companies
Milt, the guy on the far left in the photo, surveying a future development site, knew he was going to be in real estate when he was in high school. He helped his father fix up the old houses he would buy and move the family into before flipping them and doing it again. "I learned a little bit of electrical, a little plumbing, learned how to use a saw," he says. "I did enough so I knew that I liked it." He bought his first property while he was a junior at Middlebury College, followed by five lots in his senior year before joining the Army Corps of Engineers. Even when he formed his own company, he said he couldn't imagine turning into one of the region's largest developers. "I never had capital," he says. "We always owned everything and were really constrained with capital because I never wanted some 26-year-old Harvard MBA telling me what to do."
Instead, Milt goes with his gut on most of his projects. He says he's famous for "playing 52 pickup," meaning changing plans for major developments to respond to the market. Owning the land enables him to do that, and specializing in vision (he was never one for organizational skills) helped him pull off massive projects like Fair Lakes and Downtown Silver Spring. And no one knows better what it's like to take a big risk and swing and miss. National Harbor (above) opened in 2008 and 75% of the commitments Peterson had for condo sales fell through. "We lost our shirts," he says. But after years of resisting gambling, Milt says the MGM Resort is going to give National Harbor a second life. "MGM is spending $1.4B to open its resort," he says. "They're going to bring in lots and lots of people with money in their pocket." The resort is expected to open next year.
Milt has developed more than 24,000 residential lots and 34M SF of hotel and commercial real estate, including some of the premier housing developments in Northern Virginia. Peterson still owns thousands of acres across the region and all that land has the potential for 7,000 residential units, 4.5M SF of retail and 6M SF of office and industrial space.
Milt is almost 80 now, but is coy when he's asked about the future of his company. His son, Jon, is a principal and Jon's childhood friend Taylor Chess is president of retail (that's Jon and Taylor as teenagers in front of the PRC building in Tysons). In fact, Milt says Taylor "is the visionary in the company now, more so than I." Taylor spoke at our Loudoun County Boom! event last week about one of the things Peterson has done better than anyone else in the region: placemaking. That's what has made retail in Loudoun such a tough nut to crack, he says. "We don't have a lot of places out here. Providing a cool sense of place will drive businesses here."
TopGolf Loudoun on Facebook
Taylor, Jon and Milt seem like they're off to a pretty good start. The flagship TopGolf location is in a soft opening right now (the grand opening is Thursday), and early reviews are as promising as can be. TopGolf will pair with iFly, an indoor skydiving venue, to make Peterson's Commonwealth Center, across the street from Redskins Park and Miller & Smith's One Loudoun, one of Loudoun's true "places." Another, Avonlea Town Center on Route 50, will have the region's first Cinépolis. Among Milt's favorite quotes: "Do the deals you should, not the deals you can."
Contact Ethan Rothstein at ethan.rothstein@bisnow.com
Related Topics: Milt Peterson, National Harbor, The Peterson Companies, Peterson Companies, Topgolf
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Ma Huateng (, znany jako Pony Ma; ur. 29 października 1971) – chiński przedsiębiorca; założyciel i CEO korporacji Tencent, jednego z największych przedsiębiorstw internetowych na świecie.

Przypisy

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redpajama_set_name: RedPajamaWikipedia


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44th Cleveland International Film Festival announces opening and closing night movies
The festival will open with 'Military Wives' and close with 'Dream Horse.' The full lineup will be announced Friday, Feb. 28.
Author: WKYC Staff
Published: 1:40 PM CST February 20, 2020
Updated: 1:47 PM CST February 20, 2020
CLEVELAND — The 44th Cleveland International Film Festival (CIFF44) is coming this Spring and organizers have announced the movies that will both open and close this year's event.
On Wednesday, March 25 at 7:00 PM, CIFF44 will open with Military Wives. The film centers on a group of women from different backgrounds whose partners are away serving in Afghanistan. Faced with their loved ones' absences, they come together to form the very first military wives choir, helping each other through some of life's most difficult moments, and quickly find themselves on an international stage.
Credit: Cleveland International Film Festival
Peter Cattaneo, whose credits include The Full Monty, directs a cast that includes Kristin Scott Thomas and Sharon Horgan.
Opening night includes the screening of the film, followed by a reception – both of which will take place in the KeyBank State Theatre at Playhouse Square. Tickets to Opening Night at Playhouse Square are $225 per person ($200 for CIFF members).
The festival will come to a close at Tower City Center on Sunday, April 5 at 7:00 P.M. with Dream Horse, which tells the inspiring true story of Dream Alliance, an unlikely race horse bred by small town Welsh bartender, Jan Vokes. Vokes is played by Academy Award® nominee Toni Collette.
With very little money and no experience, Jan convinces her neighbors to chip in their meager earnings to help raise Dream in the hopes he can compete with the racing elites. The group's investment pays off as Dream rises through the ranks with grit and determination and goes on to race in the Welsh Grand National, showing the heart of a true champion.
All those in attendance at any of the films showing at Tower City Cinemas on Closing Night are invited to the Closing Night Ceremony (dessert reception and awards presentation) around the Tower City Center Grand Staircase after the screenings. Tickets to any Closing Night film are $14 for CIFF members and $16 for non-members.
This year marks the final time CIFF will be hosted at Tower City Cinemas. Organizers announced last month that the annual event will be permanently moving to Playhouse Square starting in 2021.
RELATED: Cleveland International Film Festival permanently moving to Playhouse Square in 2021
Tickets for this year's event will go on sale to CIFF members on Friday, March 6 before being released to the general public on Friday, March 13.
Program details for the 2020 film festival will be announced Friday, Feb. 28.
RELATED: 1917 One Shot Challenge winner from Northeast Ohio talks about meeting Sam Mendes and making his short film, Wedding Runner
RELATED: 'Like A Boss': Shaker Heights grad co-writes first feature film
RELATED: 'Minister of Culture' Michael Heaton talks with Cleveland International Film Festival goers
In memoriam: Those we lost in 2021


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The Maestro is in the House
Mon 9 Sep 2013	A List - the top stories, Oddball, Players
The Egyptian maestro, four times World Champion and former world number one, Amr Shabana, has signed a three year contract with Eye.
A Norwegian company, Eye was started in 2010. With a relentless passion for squash, Eye believes the signing of a modern day legend is welcome recognition for a brand that likes to do things differently.
Joey Barrington, International Ambassador for Eye: "The brand is a breath of fresh air for the squash market and signing a modern great is incredible. We have two legends signed with us now, the other being Jonah Barrington; you have the best of both worlds in past and present!"
"Amr is the perfect player for us. With his style and decorum on and off the court, he exudes class and shares our obsession for all things squash. Our focus on future generations and in supporting the grass-roots squash player is what we are about. Amr has been at the forefront of world squash for nearly 2 decades; he is a great inspiration to us as a company."
Amr Shabana: "I feel it was time for a change and this brand has a wonderful future. They have a cool approach with very clever racket innovations that basically make the racket lighter, without compromising on feel and touch. Their rackets are perfect for my style of game; can't wait to unleash the fury on my way back to the top!"
Joey Barrington: "Squash is moving forward so quickly, in terms of media and live television; it's great to be part of it. With the UK launch due in early 2014, this is an exciting time for us."
You can see Amr Shabana using the 'xlite 120 Control' for the first time at the PSA International 70 NetSuite Open, San Francisco (17-23 Oct), and again at the World Championship, Manchester (28-03 Nov).
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Amr Shabana Eye Rackets Featured Joey Barrington	2013-09-09
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Tetrops praeustus (frequently misspelled as "praeusta") is a small longhorn beetle found in Europe. It has recently been introduced in eastern North America.

External links

Tetropini
Beetles of Europe
Beetles described in 1758


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Abstract. This paper describes an experimental study on the effects of viscous damping walls on structures. The experimental tests were performed using an instructional shake table developed by the University Consortium on Instructional Shake Tables (UCIST).
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Was this medicine useful for you?
Lurafore (Lurafore) is an antipsychotic medicine. It works by changing the effects of chemicals in the brain.
Lurafore is used to treat schizophrenia in adults.
Lurafore is also used to treat episodes of depression in people with bipolar disorder (manic depression).
Lurafore is indicated for the treatment of patients with schizophrenia.
The efficacy of Lurafore in schizophrenia was established in five 6-week controlled studies of adult patients with schizophrenia.
The effectiveness of Lurafore for longer-term use, that is, for more than 6 weeks, has not been established in controlled studies. Therefore, the physician who elects to use Lurafore for extended periods should periodically re-evaluate the long-term usefulness of the drug for the individual patient.
Monotherapy: Lurafore is indicated as monotherapy for the treatment of patients with major depressive episodes associated with bipolar I disorder (bipolar depression). The efficacy of Lurafore was established in a 6-week monotherapy study in adult patients with bipolar depression.
Adjunctive Therapy with Lithium or Valproate: Lurafore is indicated as adjunctive therapy with either lithium or valproate for the treatment of patients with major depressive episodes associated with bipolar I disorder (bipolar depression). The efficacy of Lurafore as adjunctive therapy was established in a 6-week study in adult patients with bipolar depression who were treated with lithium or valproate.
The efficacy of Lurafore in the treatment of mania associated with bipolar disorder has not been established.
How should I use Lurafore?
Use Lurafore as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Lurafore comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Lurafore refilled.
Take Lurafore by mouth with food (at least 350 calories).
Swallow Lurafore whole. Do not split, crush, or chew before swallowing.
Do not eat grapefruit or drink grapefruit juice while you use Lurafore.
Do not suddenly stop taking Lurafore without checking with your doctor. You may have an increased risk of side effects. If you need to stop Lurafore, your doctor may need to gradually lower your dose.
Take Lurafore on a regular schedule to get the most benefit from it. Taking Lurafore at the same time each day will help you remember to take it.
Continue to take Lurafore even if you feel well. Do not miss any doses.
If you miss a dose of Lurafore, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once unless your doctor tells you to. If you are not sure what to do, call your doctor.
Ask your health care provider any questions you may have about how to use Lurafore.
This medication is used to treat certain mental/mood disorders (such as schizophrenia, depression associated with bipolar disorder). Lurafore helps you to think more clearly, feel less nervous, and take part in everyday life. It may also help to decrease hallucinations (hearing/seeing things that are not there). In addition, this medication may improve your mood, sleep, appetite, and energy level. Lurafore is a psychiatric medication that belongs to the class of drugs called atypical antipsychotics. It works by helping to restore the balance of certain natural substances in the brain.
Read the Medication Guide provided by your pharmacist before you start taking Lurafore and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Take this medication by mouth with food as directed by your doctor, usually once daily. Dosage is based on your medical condition, kidney/liver function, other drugs you are taking, and your response to treatment.
Continue taking this medication exactly as prescribed, even if you are feeling better and thinking more clearly. Do not increase your dose or take this drug more often than prescribed. Your symptoms will not improve any faster, and your risk of side effects will increase. Do not stop taking this medication without consulting your doctor.
Tell your doctor if your condition does not improve or if it worsens. It may take several weeks before you feel the full benefit of this medication.
The recommended starting dose of Lurafore is 40 mg once daily. Initial dose titration is not required. Lurafore has been shown to be effective in a dose range of 40 mg per day to 160 mg per day. The maximum recommended dose is 160 mg per day.
The recommended starting dose of Lurafore is 20 mg given once daily as monotherapy or as adjunctive therapy with lithium or valproate. Initial dose titration is not required. Lurafore has been shown to be effective in a dose range of 20 mg per day to 120 mg per day as monotherapy or as adjunctive therapy with lithium or valproate. The maximum recommended dose, as monotherapy or as adjunctive therapy with lithium or valproate, is 120 mg per day. In the monotherapy study, the higher dose range (80 mg to 120 mg per day) did not provide additional efficacy, on average, compared to the lower dose range (20 to 60 mg per day) [see Clinical Studies (14.2).
Lurafore should be taken with food (at least 350 calories). Administration with food substantially increases the absorption of Lurafore. Administration with food increases the AUC approximately 2-fold and increases the Cmax approximately 3-fold. In the clinical studies, Lurafore was administered with food.
Dose adjustment is recommended in moderate (creatinine clearance: 30 to <50 mL/min) and severe renal impairment (creatinine clearance <30 mL/min) patients. The recommended starting dose is 20 mg per day. The dose in these patients should not exceed 80 mg per day.
Dose adjustment is recommended in moderate (Child-Pugh Score = 7 to 9) and severe hepatic impairment (Child-Pugh Score = 10 to 15) patients. The recommended starting dose is 20 mg per day. The dose in moderate hepatic impairment patients should not exceed 80 mg per day and the dose in severe hepatic impairment patients should not exceed 40 mg/day.
Lurafore should not be used concomitantly with a strong CYP3A4 inhibitor (e.g., ketoconazole, clarithromycin, ritonavir, voriconazole, mibefradil, etc.).
If Lurafore is being prescribed and a moderate CYP3A4 inhibitor (e.g. diltiazem, atazanavir, erythromycin, fluconazole, verapamil etc.) is added to the therapy, the Lurafore dose should be reduced to half of the original dose level. Similarly, if a moderate CYP3A4 inhibitor is being prescribed and Lurafore is added to the therapy, the recommended starting dose of Lurafore is 20 mg per day, and the maximum recommended dose of Lurafore is 80 mg per day.
Grapefruit and grapefruit juice should be avoided in patients taking Lurafore, since these may inhibit CYP3A4 and alter Lurafore concentrations.
Lurafore should not be used concomitantly with a strong CYP3A4 inducer (e.g., rifampin, avasimibe, St. John's wort, phenytoin, carbamazepine, etc.). If Lurafore is used concomitantly with a moderate CYP3A4 inducer, it may be necessary to increase the Lurafore dose after chronic treatment (7 days or more) with the CYP3A4 inducer.
What other drugs will affect Lurafore?
Lurafore is predominantly metabolized by CYP3A4. Lurafore should not be used concomitantly with strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir, voriconazole, mibefradil, etc.) or strong CYP3A4 inducers (e.g., rifampin, avasimibe, St. John's wort, phenytoin, carbamazepine, etc.). The Lurafore dose should be reduced to half of the original level when used concomitantly with moderate inhibitors of CYP3A4 (e.g., diltiazem, atazanavir, erythromycin, fluconazole, verapamil, etc.). If Lurafore is used concomitantly with a moderate CYP3A4 inducer, it may be necessary to increase the Lurafore dose.
Lithium: It is not necessary to adjust the Lurafore dose when used concomitantly with lithium (Figure 1).
Valproate: It is not necessary to adjust the Lurafore dose when used concomitantly with valproate. A dedicated drug-drug interaction study has not been conducted with valproate and Lurafore. Based on pharmacokinetic data from the bipolar depression studies valproate levels were not affected by Lurafore, and Lurafore concentrations were not affected by valproate.
Grapefruit: Grapefruit and grapefruit juice should be avoided in patients taking Lurafore, since these may inhibit CYP3A4 and alter Lurafore concentrations.
No dose adjustment is needed for lithium, substrates of P-gp, CYP3A4 (Figure 2) or valproate when coadministered with Lurafore. ).
Lurafore is not a controlled substance.
Lurafore has not been systematically studied in humans for its potential for abuse or physical dependence or its ability to induce tolerance. While clinical studies with Lurafore did not reveal any tendency for drug-seeking behavior, these observations were not systematic and it is not possible to predict the extent to which a CNS-active drug will be misused, diverted and/or abused once it is marketed. Patients should be evaluated carefully for a history of drug abuse, and such patients should be observed carefully for signs of Lurafore misuse or abuse (e.g., development of tolerance, drug-seeking behavior, increases in dose).
What are the possible side effects of Lurafore?
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.
The information below is derived from an integrated clinical study database for Lurafore consisting of 3799 patients exposed to one or more doses of Lurafore for the treatment of schizophrenia and bipolar depression in placebo-controlled studies. This experience corresponds with a total experience of 1250.9 patient-years. A total of 1106 Lurafore-treated patients had at least 24 weeks and 371 Lurafore-treated patients had at least 52 weeks of exposure.
Adverse events during exposure to study treatment were obtained by general inquiry and voluntarily reported adverse experiences, as well as results from physical examinations, vital signs, ECGs, weights and laboratory investigations. Adverse experiences were recorded by clinical investigators using their own terminology. In order to provide a meaningful estimate of the proportion of individuals experiencing adverse events, events were grouped in standardized categories using MedDRA terminology.
The following findings are based on the short-term, placebo-controlled premarketing studies for schizophrenia in which Lurafore was administered at daily doses ranging from 20 to 160 mg (n=1508).
The most common adverse reactions (incidence ≥ 5% and at least twice the rate of placebo) in patients treated with Lurafore were somnolence, akathisia, extrapyramidal symptoms, and nausea.
A total of 9.5% (143/1508) Lurafore-treated patients and 9.3% (66/708) of placebo-treated patients discontinued due to adverse reactions. There were no adverse reactions associated with discontinuation in subjects treated with Lurafore that were at least 2% and at least twice the placebo rate.
Adverse reactions associated with the use of Lurafore (incidence of 2% or greater, rounded to the nearest percent and Lurafore incidence greater than placebo) that occurred during acute therapy (up to 6 weeks in patients with schizophrenia) are shown in Table 15.
Akathisia and extrapyramidal symptoms were dose-related. The frequency of akathisia increased with dose up to 120 mg/day (5.6% for Lurafore 20 mg, 10.7% for Lurafore 40 mg, 12.3% for Lurafore 80 mg, and 22.0% for Lurafore 120 mg). Akathisia was reported by 7.4% (9/121) of patients receiving 160 mg/day. Akathisia occurred in 3.0% of subjects receiving placebo. The frequency of extrapyramidal symptoms increased with dose up to 120 mg/day (5.6% for Lurafore 20 mg, 11.5% for Lurafore 40 mg, 11.9% for Lurafore 80 mg, and 22.0% for Lurafore 120 mg).
The following findings are based on the short-term, placebo-controlled premarketing study for bipolar depression in which Lurafore was administered at daily doses ranging from 20 to 120 mg (n=331).
The most common adverse reactions (incidence ≥ 5%, in either dose group, and at least twice the rate of placebo) in patients treated with Lurafore were akathisia, extrapyramidal symptoms, somnolence, nausea, vomiting, diarrhea, and anxiety.
A total of 6.0% (20/331) Lurafore-treated patients and 5.4% (9/168) of placebo-treated patients discontinued due to adverse reactions. There were no adverse reactions associated with discontinuation in subjects treated with Lurafore that were at least 2% and at least twice the placebo rate.
Adverse reactions associated with the use of Lurafore (incidence of 2% or greater, rounded to the nearest percent and Lurafore incidence greater than placebo) that occurred during acute therapy (up to 6 weeks in patients with bipolar depression) are shown in Table 16.
In the short-term, placebo-controlled study (involving lower and higher Lurafore dose ranges) the adverse reactions that occurred with a greater than 5% incidence in the patients treated with Lurafore in any dose group and greater than placebo in both groups were nausea (10.4%, 17.4%), somnolence (7.3%, 13.8%), akathisia (7.9%, 10.8%), and extrapyramidal symptoms (4.9%, 9.0%) for Lurafore 20 to 60 mg/day and Lurafore 80 to 120 mg/day, respectively.
The following findings are based on two short-term, placebo-controlled premarketing studies for bipolar depression in which Lurafore was administered at daily doses ranging from 20 to 120 mg as adjunctive therapy with lithium or valproate (n=360).
The most common adverse reactions (incidence ≥ 5% and at least twice the rate of placebo) in subjects treated with Lurafore were akathisia and somnolence.
A total of 5.8% (21/360) Lurafore-treated patients and 4.8% (16/334) of placebo-treated patients discontinued due to adverse reactions. There were no adverse reactions associated with discontinuation in subjects treated with Lurafore that were at least 2% and at least twice the placebo rate.
Adverse reactions associated with the use of Lurafore (incidence of 2% or greater, rounded to the nearest percent and Lurafore incidence greater than placebo) that occurred during acute therapy (up to 6 weeks in patients with bipolar depression) are shown in Table 17.
In the short-term, placebo-controlled schizophrenia studies, for Lurafore-treated patients, the incidence of reported events related to extrapyramidal symptoms (EPS), excluding akathisia and restlessness, was 13.5% versus 5.8% for placebo-treated patients. The incidence of akathisia for Lurafore-treated patients was 12.9% versus 3.0% for placebo-treated patients. Incidence of EPS by dose is provided in Table 18.
In the short-term, placebo-controlled monotherapy bipolar depression study, for Lurafore-treated patients, the incidence of reported events related to EPS, excluding akathisia and restlessness was 6.9% versus 2.4% for placebo-treated patients. The incidence of akathisia for Lurafore-treated patients was 9.4% versus 2.4% for placebo-treated patients. Incidence of EPS by dose groups is provided in Table 19.
In the short-term, placebo-controlled adjunctive therapy bipolar depression studies, for Lurafore-treated patients, the incidence of EPS, excluding akathisia and restlessness, was 13.9% versus 8.7% for placebo. The incidence of akathisia for Lurafore-treated patients was 10.8% versus 4.8% for placebo-treated patients. Incidence of EPS is provided in Table 20.
In the short-term, placebo-controlled schizophrenia and bipolar depression studies, data was objectively collected on the Simpson Angus Rating Scale (SAS) for extrapyramidal symptoms (EPS), the Barnes Akathisia Scale (BAS) for akathisia and the Abnormal Involuntary Movement Scale (AIMS) for dyskinesias.
The mean change from baseline for Lurafore-treated patients for the SAS, BAS and AIMS was comparable to placebo-treated patients, with the exception of the Barnes Akathisia Scale global score (Lurafore, 0.1; placebo, 0.0). The percentage of patients who shifted from normal to abnormal was greater in Lurafore-treated patients versus placebo for the BAS (Lurafore, 14.4%; placebo, 7.1%), the SAS (Lurafore, 5.0%; placebo, 2.3%) and the AIMS (Lurafore, 7.4%; placebo, 5.8%).
The mean change from baseline for Lurafore-treated patients for the SAS, BAS and AIMS was comparable to placebo-treated patients. The percentage of patients who shifted from normal to abnormal was greater in Lurafore-treated patients versus placebo for the BAS (Lurafore, 8.4%; placebo, 5.6%), the SAS (Lurafore, 3.7%; placebo, 1.9%) and the AIMS (Lurafore, 3.4%; placebo, 1.2%).
The mean change from baseline for Lurafore-treated patients for the SAS, BAS and AIMS was comparable to placebo-treated patients. The percentage of patients who shifted from normal to abnormal was greater in Lurafore-treated patients versus placebo for the BAS (Lurafore, 8.7%; placebo, 2.1%), the SAS (Lurafore, 2.8%; placebo, 2.1%) and the AIMS (Lurafore, 2.8%; placebo, 0.6%).
Class Effect: Symptoms of dystonia, prolonged abnormal contractions of muscle groups, may occur in susceptible individuals during the first few days of treatment. Dystonic symptoms include: spasm of the neck muscles, sometimes progressing to tightness of the throat, swallowing difficulty, difficulty breathing, and/or protrusion of the tongue. While these symptoms can occur at low doses, they occur more frequently and with greater severity with high potency and at higher doses of first-generation antipsychotic drugs. An elevated risk of acute dystonia is observed in males and younger age groups.
In the short-term, placebo-controlled schizophrenia clinical studies, dystonia occurred in 4.2% of Lurafore-treated subjects (0.0% Lurafore 20 mg, 3.5% Lurafore 40 mg, 4.5% Lurafore 80 mg, 6.5% Lurafore 120 mg and 2.5% Lurafore 160 mg) compared to 0.8% of subjects receiving placebo. Seven subjects (0.5%, 7/1508) discontinued clinical trials due to dystonic events – four were receiving Lurafore 80 mg/day and three were receiving Lurafore 120 mg/day.
In the short-term, flexible-dose, placebo-controlled monotherapy bipolar depression study, dystonia occurred in 0.9% of Lurafore-treated subjects (0.0% and 1.8% for Lurafore 20 to 60 mg/day and Lurafore 80 to 120 mg/day, respectively) compared to 0.0% of subjects receiving placebo. No subject discontinued the clinical study due to dystonic events.
In the short-term, flexible-dose, placebo-controlled adjunctive therapy bipolar depression studies, dystonia occurred in 1.1% of Lurafore-treated subjects (20 to 120 mg) compared to 0.6% of subjects receiving placebo. No subject discontinued the clinical study due to dystonic events.
Following is a list of adverse reactions reported by patients treated with Lurafore at multiple doses of ≥ 20 mg once daily within the premarketing database of 2905 patients with schizophrenia. The reactions listed are those that could be of clinical importance, as well as reactions that are plausibly drug-related on pharmacologic or other grounds. Reactions listed in Table 15 or those that appear elsewhere in the Lurafore label are not included. Although the reactions reported occurred during treatment with Lurafore, they were not necessarily caused by it.
Reactions are further categorized by organ class and listed in order of decreasing frequency according to the following definitions: those occurring in at least 1/100 patients (frequent) (only those not already listed in the tabulated results from placebo-controlled studies appear in this listing); those occurring in 1/100 to 1/1000 patients (infrequent); and those occurring in fewer than 1/1000 patients (rare).
Serum Creatinine: In short-term, placebo-controlled trials, the mean change from Baseline in serum creatinine was +0.05 mg/dL for Lurafore-treated patients compared to +0.02 mg/dL for placebo-treated patients. A creatinine shift from normal to high occurred in 3.0% (43/1453) of Lurafore-treated patients and 1.6% (11/681) on placebo. The threshold for high creatinine value varied from > 0.79 to > 1.3 mg/dL based on the centralized laboratory definition for each study (Table 21).
Serum Creatinine: In the short-term, flexible-dose, placebo-controlled monotherapy bipolar depression study, the mean change from Baseline in serum creatinine was +0.01 mg/dL for Lurafore-treated patients compared to -0.02 mg/dL for placebo-treated patients. A creatinine shift from normal to high occurred in 2.8% (9/322) of Lurafore-treated patients and 0.6% (1/162) on placebo (Table 22).
Serum Creatinine: In short-term, placebo-controlled premarketing adjunctive studies for bipolar depression, the mean change from Baseline in serum creatinine was +0.04 mg/dL for Lurafore-treated patients compared to -0.01 mg/dL for placebo-treated patients. A creatinine shift from normal to high occurred in 4.3% (15/360) of Lurafore-treated patients and 1.6% (5/334) on placebo (Table 23).
What is the most important information I should know about Lurafore?
Lurafore is not for use in psychotic conditions related to dementia. Lurafore may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions.
You should not use this medication if you are allergic to Lurafore, or if you are also using ketoconazole (Extina, Ketozole, Nizoral, Xolegal) or rifampin (Rifater, Rifadin, Rifamate).
Before you take Lurafore, tell your doctor if you have liver disease, kidney disease, heart disease, high blood pressure, heart rhythm problems, a history of heart attack or stroke, high cholesterol or triglycerides, low white blood cell (WBC) counts, seizures, diabetes, Parkinson's disease, trouble swallowing, or a history of breast cancer or suicidal thoughts.
While you are taking Lurafore, you may be more sensitive to temperature extremes such as very hot or cold conditions. Avoid getting too cold, or becoming overheated or dehydrated. Drink plenty of fluids, especially in hot weather and during exercise. It is easier to become dangerously overheated and dehydrated while you are taking Lurafore.
Lurafore may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
Drinking alcohol can increase certain side effects of Lurafore.
Stop using Lurafore and call your doctor at once if you have very stiff (rigid) muscles, high fever, sweating, confusion, fast or pounding heartbeats, feeling like you might pass out, tremors, or twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs.
There are many other drugs that can interact with Lurafore. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.
DailyMed. "LURASIDONE HYDROCHLORIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
PubChem. "Lurasidone". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
DrugBank. "Lurasidone". http://www.drugbank.ca/drugs/DB08815 (accessed September 17, 2018).
The results of a survey conducted on ndrugs.com for Lurafore are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Lurafore. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.
To what extent do I have to use Lurafore before I begin to see changes in my health conditions?
As part of the reports released by ndrugs.com website users, it takes 1 day and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Lurafore. To get the time effectiveness of using Lurafore drug by other patients, please click here.


text:
Q: Python pandas groupby with lambda My dataframe:
df = pd.DataFrame({'company': ['A', 'A', 'A', 'A', 'A','B','B','B','B','B'],
                      'offered': [1, 1, 0, 1, 1, 1, 0, 0, 1, 1],
                      'accepted': [0, 1, 0, 1, 1, 0, 0, 0, 1, 0]})

    company offered accepted
0   A       1       0
1   A       1       1
2   A       0       0
3   A       1       1
4   A       1       1
5   B       1       0
6   B       0       0
7   B       0       0
8   B       1       1
9   B       1       0

I want my final result looks like this:
df2 = df.groupby('company')[['offered', 'accepted']].agg('sum')
df2['accept_rate'] = df2['accepted']/df2['offered']
df2

    offered accepted    accept_rate
company
A   4       3           0.750000
B   3       1           0.333333

However, I would like to do this in one shot (e.g., using lambda). Here's what I have tried
df['accept_rate'] = df['accepted'] / df['offered']
df.groupby('company')[['offered', 'accepted', 'accept_rate']].agg({'offered': 'sum',
                                                    'accepted': 'sum',
                                                    'accept_rate': lambda x: df['accepted'].sum()/df['offered'].sum()})

    offered accepted    accept_rate
company
A   4       3           0.571429
B   3       1           0.571429

As you can see the accept_rate = 0.571429 is for the total/combined companies.
How can I make the accept_rate to look like my desired final result?
Thanks in advance!

A: You want assign
df.groupby('company').agg({'offered': 'sum', 'accepted': 'sum'}).assign(accept_rate=lambda x: x['accepted']/x['offered'])


What sets us apart from others? Simply stated: we are pretty darn good at what we do! We can discuss design ideas, make drawings and be by your side from start to finish on projects big and small.
Step 3: Final result: Beautiful Wrought Iron Gate!


Ground floor: Open plan lounge/living room/ kitchen. Fully equipped kitchen with washing machine, dishwasher, fridge/freezer, hob/oven, microwave etc. Comfortably furnished lounge/diner area (approx. 20 sq.m) with sofas, chairs & tables plus a lovely open fireplace of stone and wood. A CD/Radio/Cassette is also provided. Double French windows lead to a private patio with furniture and barbecue.
First floor: The two bedrooms are tastefully furnished with one having a king size bed and the other being twin bedded. The bathroom has a corner bath with enclosed shower as well as a washbasin set in grey granite and housed in an old style stand. There is a separate toilet with washbasin and a landing with staircase leading to the living area.


123Grandprix complete workstation, consisting of a GT spoiler desk, LXE office chair and a GT Diamond plate chair mat. The desk is available in the colors red, black and silver. The LXE office chair is available in red, yellow, black, silver and in the carbon fiber look. Look at the separate articles on our website for more product information.


text:
Mount Beck kan syfta på följande platser:

Antarktis

 Mount Beck, Östantarktis,
 Mount Beck, centrala Antarktis,

Robotskapade Antarktisförgreningar


A traditional latte made all the better because it is sweetened with Pure Via sweetener and uses reduced fat milk to save calories. Almond extract provides a nice change of taste.
Whisk coffee and Pure Via sweetener in a 2-cup (500 mL) glass measuring cup until blended. Divide mixture evenly between 4 small mugs.
Whisk heated milk and extract in the same glass measure until frothy. Evenly spoon milk onto top of each mug of coffee and serve.
* Plain soy milk may be substituted for the milk.
VARIATION: Other flavor lattes can easily be made using various flavors of extracts such as rum, peppermint or vanilla.


Do you or someone you know have additional needs? Ever tried kayaking? Now is your chance. In 2018 we'll be offering specific kayaking sessions for people with any health impairments, disabilities, mental health issues or learning difficulties. After 7 years of running Lizard Adventure we have started a new social enterprise – Access Lizard Adventure CIC. See our new page for more info or contact us to find out more.
We had two successful open events this year in June and October where lots of adults and some children had great fun kayaking in Hayle Harbour (see the photos). We all had a great time and the feedback was very positive, and everyone wants to come back for more. We are currently putting together a programme to start in April next year. So, if you'd like to get involved and have not been before please get your name on our mailing list. More details in the new year.
‹ Romany Sport: A female perspective.


 consolidation_company_dropdown 1.00 Freeware Download - Unbelievable and SUPER easy to use software makes creating a drop down menus a BREEZE!
Unbelievable and SUPER easy to use software makes creating a drop down menus a BREEZE! You'll be able to choose, Fonts Font Colors Background Colors Font Styles Font Weights, Create Drop Down Menus that PERFECTLY match your website. Easy to use no programming experience needed.
349 downloads Why don't you design your new company logo all by yourself?
8 downloads Publishing Company Barcodes Generator Software is used to automate ordering and inventory management systems for retailers, independent book publishers and distributors successively various book publishing companies.


text:
Hayes, F. et al.
Hayes, Hallet, Cao,
Insertion mutagenesis as a tool in the modification of protein function. Extended substrate specificity conferred by pentapeptide insertions in the omega-loop of TEM-1 beta-lactamase.
The TEM-1 beta-lactamase enzyme efficiently hydrolyzes beta-lactam antibiotics such as ampicillin but cleaves third generation cephalosporin antibiotics poorly. Variant beta-lactamases that conferred elevated levels of resistance to the cephalosporin ceftazidime were identified in a set of beta-lactamase derivatives previously generated by pentapeptide scanning mutagenesis in which a variable 5-amino acid cassette was introduced randomly in the target protein. This mutagenesis procedure was also modified to allow the direct selection of variant beta-lactamases with pentapeptide insertions that conferred extended substrate specificities. All insertions associated with enhanced resistance to ceftazidime were targetted to the 19-amino acid Omega-loop region, which forms part of the catalytic pocket of the beta-lactamase enzyme. However, pentapeptide insertions in the C- and N-terminal halves of this region had different effects on the ability of the enzyme to hydrolyze ampicillin in vivo. Larger insertions that increased the length of the Omega-loop by up to 2-fold also retained catalytic activity toward ampicillin and/or ceftazidime in vivo. In accord with previous substitution mutation studies, these results emphasize the extreme flexibility of the Omega-loop with regards the primary structure requirements for ceftazidime hydrolysis by beta-lactamase. The potential of pentapeptide scanning mutagenesis in mimicking evolution events that result from the insertion and excision of transposons in nature is discussed.[1]
Insertion mutagenesis as a tool in the modification of protein function. Extended substrate specificity conferred by pentapeptide insertions in the omega-loop of TEM-1 beta-lactamase. Hayes, F., Hallet, B., Cao, Y. J. Biol. Chem. (1997) [Pubmed]


text:
Home » Features » Hidden Covid triggering rare heart condition; timely diagnosis is must: Experts
Hidden Covid triggering rare heart condition; timely diagnosis is must: Experts
An 18-year-old boy with no history of any illness was rushed to Sir Ganga Ram Hospital (SGRH) after he fell unconscious.
Ashish Srivastava | New Delhi | June 16, 2021 2:52 pm
(Representational Image: iStock)
While the wrath of Covid-19 seems to be settling down, what follows now is the sequelae or secondary conditions directly resulting from the viral infection. Perhaps, one of the most concerning is myocarditis, which is defined as inflammation of the heart muscle, whose prevalence is rising among recovered patients of Covid-19.
The hospitals are reporting patients coming with complaints of heart-related issues. Surprisingly, many are found carrying the antibodies of the viral infection. Doctors observed that the undetected Covid infection is triggering the rise in cardiac illnesses.
An 18-year-old boy with no history of any illness was rushed to Sir Ganga Ram Hospital (SGRH) after he fell unconscious. His echocardiography revealed a weak and poorly functioning, enlarged heart that had started to fail. The doctors conducted antibodies test on the patient and found an unusually high level of it.
Similarly, a 28-year-old female with no previous history of a comorbid condition or any cardiac or respiratory illness was admitted to Moolchand Hospital with complaints of multiple episodes of loose stool and vomiting. The hospital did an antibody test on her as a precaution and was surprised to find her possessing high titers of it.
The patient suffered heart failure but got recovered in 12 days of stay at the hospital.
Dr Bhagwan Mantri, Consultant Pulmonologist at Moolchand who followed up the case said that undetectable Covid-19 infection is driving the disease burden, especially associated with heart and lungs.
"We saw such cases in the first wave as well but then, most of the patients had a known history of Covid infection. Now, what are we noticing is that patients are coming with inflammatory markers in their body with no past illnesses. During the investigation, Covid-19 is being found a causation behind their medical condition," he noted.
Dr Ashwani Mehta, Senior Consultant, Department of Cardiology, SGRH said that many of his patients suffering from Covid associated Myocarditis revealed that they never tested positive for the Covid-19.
"One of my patients told me that his family member suffered from Covid-19, but he never tested positive. However, the patient exhibited a high level of SARS-CoV-2 antibodies," he said.
Mantri said that since the infection has seeped into the community wherein tracing every Covid-19 patient seems impossible, one should remain watchful of the symptoms he or she experience.
"Noting warnings and identifying symptoms can help in early diagnosis of the Covid induced condition," he added.
Speaking on warning signs, Mehta said that both in the known history of Covid infection and untracked cases, some symptoms may persist which the patients should not ignore.
"Patients generally experience palpitations, fatigue, breathlessness, puffiness and swelling over the face," he informed.
Doctors suggested that regular follow-up and screening is a must in Covid recovered patients to diagnose any post-Covid cardiac trauma.
"Since a load of asymptomatic Covid cases is high who mostly go undiagnosed, people must check for early warning signs since myocarditis is a potentially life-threatening condition," Mehta said.
rare heart condition
UP Govt inks deal with Hyderabad-based InstaShield to counter Covid-19
Study reveals most long covid symptoms resolve within a year after mild infection
Advisory on guidelines for diabetic patients in Covid-19


text:
Tea for Two (1950)
Format: DVD Genre: Musicals (Theatrical)
Musical comedy based on "No, No, Nanette" stars Doris Day as a would-be stage singer who, in order to get backing for her Broadway show out of her uncle, wagers that she can say "no" to every question put to her for 24 hours. Gordon MacRae, Gene Nelson, Eve Arden, and Billy De Wolfe also star; songs include "I Know That You Know," "I Want to Be Happy," "I Only Have Eyes for You," and the title tune. 98 min. Standard; Soundtracks: English Dolby Digital mono, French Dolby Digital mono; Subtitles: English, French.
Doris Day & Pat Boone
Gordon MacRae
Billy De Wolfe
S.Z. Sakall
Studio: Warner Archives
Attributes: Manufactured on Demand, Full Frame, Dubbed, Amaray Case
Subtitles: ENG, FRE
Dubbed: FRE


text:
Soccerlens · Dec 21, 2018
'Sign him up', 'Get him' – 27-yr-old dreams of playing for Celtic, some fans react
� originally posted on Sportslens.com Former Celtic defender Erik Sviatchenko has revealed that he wants to play for the club again in future. The Danish defender was sold to Midtjylland in the summer after being loaned out to them during the second half of last season. Sviatchenko claims that Rodgers never explained to him why he was let go and he would like to know what he could have done differently. He said: "My dream would be to play for Celtic again. But it's not up to me...
Erik Sviatchenko
Soccerlens
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All kinds of things need not be claimed literally and on encounter value. There are a number of aspects related to any individual topic or any expose and hence you do analyze all the facets of the same. Homework also, if taken literally translates as the work that ought to be and that needs staying done at home. That is not all that is concerning homework. Homework is a well concept, which has been through it since lot of as well as haunts the lives of all the different students. Every student always be do homework and coating the assignments they are administered but it is much less easy as it seems to be.
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Blum-Novotest, a leading supplier of innovative and high-quality measuring and testing technology, will be featuring the new measuring and evaluation software M4P at the CONTROL show in Stuttgart (hall 3 stand 3406). The newly developed software was specifically designed for the company's post-process measuring machines and can now be used for even more demanding tasks thanks to a total sampling rate of up to 100%.
Peter Mösle, Sales Manager Measuring Machines, explains: "Measuring machines from Blum-Novotest are generally used for the 100% measurement of mostly rotationally symmetric components during medium and large-volume production in the automotive industry. Integrated in fully automated production lines, they document the quality of each manufactured component, allowing the immediate rejection of faulty parts and implementation of a closed loop process for managing the machine tool. Our new software M4P has enabled us to improve all aspects of the previous, proven software solution for these machines."
Thanks to the new measuring and evaluation software M4P, which has been specially developed for dynamic measurement tasks, Blum-Novotest is able to offer a software solution that additionally satisfies the test process suitability and measurement uncertainty analysis according to VDA Volume 5 of the German Association of the Automotive Industry (VDA). The software is fully compatible with the current statistical software solutions from Q-DAS. Measurement data can be output as an AQDEF file and contains all the necessary K fields specified by the automotive standard.
The newly developed measuring and evaluation software M4P was specifically designed for the post-process measuring machines from Blum-Novotest.
The measuring and evaluation software M4P displays current SET and ACTUAL values, including bar graphs and measured value trends.
The detailed view of a measurement characteristic shows the course and delivers precise measured values at the click of a mouse.
The intelligent algorithms for calculation are yet another highlight. The measurement uncertainty must be taken into account for each measured value, for example due to temperature fluctuations, factors that influence probing or dirt. If the measurement uncertainty is 1 µm with a tolerance of 10 µm, a remaining tolerance of just 9 µm is effectively available for production. The difficulty now lies in determining this measurement uncertainty precisely for each characteristic, since it can vary. This is particularly important for dynamic diameter measurements, as the axis of rotation also needs to be compensated. Consideration of the measurement uncertainty and the improved correction strategy lead to higher process stability.
The high level of user-friendliness results from many programming refinements. The user is guided intuitively when creating new measurements, can toggle between functions and views at lightning speed by means of quick navigation and is graphically supported.
Another new feature is the box plot view, which allows critical and stable characteristics to be distinguished at a glance – even with a large number of existing characteristics. For example, when measuring a brake disc for measured value acquisition, 15-20 probes are used at the same time, from which up to 100 characteristics can be generated in the evaluation. Of course, not only absolute dimensions, but also form and position deviations for each component are stored in an individual measuring report. Through the dynamic presentation and highlighting of process-critical characteristics, the operator immediately recognises unwanted deviations or trends and is able to take appropriate countermeasures.
The measuring and evaluation software M4P incorporates the latest metrological findings as well as more than 35 years of experience in production measurement technology. The newly redeveloped software is designed for the current 64-bit version of Windows. "Every aspect of the previous software solution has been improved in the new software. We now meet all the market requirements and also offer a significant increase in user-friendliness, flexibility, speed and traceability, as well as greater precision than in the past," Peter Mösle says, in summary.


Four big-ticket National Company Law Tribunal (NCLT) cases — Essar Steel, Bhushan Power and Steel, Jaypee Infratech, and Alok Industries — will see their resolution getting pushed to the next financial year (2019-20), increasing the provisioning burden on lenders. It will also postpone the benefit of reversal of money set aside as provisions.
These cases were in advanced stages of resolution, and their settlement was expected by the end of the March quarter of 2018-19. This would have brought relief to lenders in the form of release of provisions made, which could have been used for some other stressed accounts.
Instead, many banks will now have to make extra provisions, said senior public sector bank executives. These accounts, part of the RBI's first list, were classified as non-performing assets (NPAs) in March 2016, and were taken to the NCLT in 2017-18 for insolvency proceedings.
In the normal course, lenders would have to make 100 per cent provisions in four years. The aggregate provisions for these were about 70 per cent, according to ICRA's estimates.
Banks with exposure to Essar Steel were expecting significant write-backs on account of the account's resolution by March 31, 2019. However, if the account remains unresolved, they would need to increase the provisions, affecting their balance sheets.
For example, SBI is expecting to write back about Rs 6,000 crore from Essar's resolution in Q4, according to a senior official at SBI. However, if the resolution does not happen, the bank would need to make additional provisions, said the official. SBI's provisions for List 1 cases were about 66 per cent.
Earlier, Mallikarjuna Rao, MD and CEO of Allahabad Bank, had said the bank was expecting a write-back of Rs 360 crore from all NCLT accounts by the end of Q4. Of this, a major chunk would be from Essar, he had said.
According to Mrutyunjay Mahapatra, MD and CEO of Syndicate Bank, if the Essar Steel account remains unresolved till March 31, the bank will have to make ageing provisions.
In June 2017, the RBI had asked banks to refer 12 accounts with exposure of Rs 2.5 trillion to the NCLT under the Insolvency and Bankruptcy Code. Out of these, three accounts aggregating Rs 80,000 crore have been resolved: Bhushan Steel (went to Tata Steel), Electrosteel (to Vedanta) and Monnet Ispat (JSW).


8dd7bc3319deb2b77c5d07a51b7d6cd7e11b5beb0The Android Open Source Project * Kenneth Almquist.
14dd7bc3319deb2b77c5d07a51b7d6cd7e11b5beb0The Android Open Source Project *    notice, this list of conditions and the following disclaimer.
17dd7bc3319deb2b77c5d07a51b7d6cd7e11b5beb0The Android Open Source Project *    documentation and/or other materials provided with the distribution.
20dd7bc3319deb2b77c5d07a51b7d6cd7e11b5beb0The Android Open Source Project *    without specific prior written permission.
32dd7bc3319deb2b77c5d07a51b7d6cd7e11b5beb0The Android Open Source Project * SUCH DAMAGE.
52dd7bc3319deb2b77c5d07a51b7d6cd7e11b5beb0The Android Open Source Project * This file implements the input routines used by the parser.
55dd7bc3319deb2b77c5d07a51b7d6cd7e11b5beb0The Android Open Source Project#include "shell.h"
56dd7bc3319deb2b77c5d07a51b7d6cd7e11b5beb0The Android Open Source Project#include "redir.h"
57dd7bc3319deb2b77c5d07a51b7d6cd7e11b5beb0The Android Open Source Project#include "syntax.h"
58dd7bc3319deb2b77c5d07a51b7d6cd7e11b5beb0The Android Open Source Project#include "input.h"
59dd7bc3319deb2b77c5d07a51b7d6cd7e11b5beb0The Android Open Source Project#include "output.h"
60dd7bc3319deb2b77c5d07a51b7d6cd7e11b5beb0The Android Open Source Project#include "options.h"
61dd7bc3319deb2b77c5d07a51b7d6cd7e11b5beb0The Android Open Source Project#include "memalloc.h"
62dd7bc3319deb2b77c5d07a51b7d6cd7e11b5beb0The Android Open Source Project#include "error.h"
63dd7bc3319deb2b77c5d07a51b7d6cd7e11b5beb0The Android Open Source Project#include "alias.h"
64dd7bc3319deb2b77c5d07a51b7d6cd7e11b5beb0The Android Open Source Project#include "parser.h"
65dd7bc3319deb2b77c5d07a51b7d6cd7e11b5beb0The Android Open Source Project#include "myhistedit.h"
84dd7bc3319deb2b77c5d07a51b7d6cd7e11b5beb0The Android Open Source Project * contains information about the current file being read.
120dd7bc3319deb2b77c5d07a51b7d6cd7e11b5beb0The Android Open Source ProjectINCLUDE "input.h"
121dd7bc3319deb2b77c5d07a51b7d6cd7e11b5beb0The Android Open Source ProjectINCLUDE "error.h"
140dd7bc3319deb2b77c5d07a51b7d6cd7e11b5beb0The Android Open Source Project * Read a line from the script.
168dd7bc3319deb2b77c5d07a51b7d6cd7e11b5beb0The Android Open Source Project * Read a character from the script, returning PEOF on end of file.
169dd7bc3319deb2b77c5d07a51b7d6cd7e11b5beb0The Android Open Source Project * Nul characters in the input are silently discarded.
280dd7bc3319deb2b77c5d07a51b7d6cd7e11b5beb0The Android Open Source Project *    from a string so we can't refill the buffer, return EOF.
281dd7bc3319deb2b77c5d07a51b7d6cd7e11b5beb0The Android Open Source Project * 3) If the is more stuff in this buffer, use it else call read to fill it.
282dd7bc3319deb2b77c5d07a51b7d6cd7e11b5beb0The Android Open Source Project * 4) Process input up to the next newline, deleting nul characters.
370dd7bc3319deb2b77c5d07a51b7d6cd7e11b5beb0The Android Open Source Project * Undo the last call to pgetc.  Only one character may be pushed back.
371dd7bc3319deb2b77c5d07a51b7d6cd7e11b5beb0The Android Open Source Project * PEOF may be pushed back.
382dd7bc3319deb2b77c5d07a51b7d6cd7e11b5beb0The Android Open Source Project * Push a string back onto the input at this current parsefile level.
383dd7bc3319deb2b77c5d07a51b7d6cd7e11b5beb0The Android Open Source Project * We handle aliases this way.
429dd7bc3319deb2b77c5d07a51b7d6cd7e11b5beb0The Android Open Source Project * old input onto the stack first.
455dd7bc3319deb2b77c5d07a51b7d6cd7e11b5beb0The Android Open Source Project * interrupts off.
477dd7bc3319deb2b77c5d07a51b7d6cd7e11b5beb0The Android Open Source Project * Like setinputfile, but takes input from a string.
497dd7bc3319deb2b77c5d07a51b7d6cd7e11b5beb0The Android Open Source Project * adds a new entry to the stack and popfile restores the previous level.
541dd7bc3319deb2b77c5d07a51b7d6cd7e11b5beb0The Android Open Source Project * Return to top level.
555dd7bc3319deb2b77c5d07a51b7d6cd7e11b5beb0The Android Open Source Project * after a fork is done.
558dd7bc3319deb2b77c5d07a51b7d6cd7e11b5beb0The Android Open Source Project * as it is still running in the parent.
564dd7bc3319deb2b77c5d07a51b7d6cd7e11b5beb0The Android Open Source Project * pipe!


Image Title: He Is Risen Coloring Page Crafting The Word Of God Pertaining To Jesus Decor 17. Post Title: Jesus Is Risen Coloring Page. Filename: he-is-risen-coloring-page-crafting-the-word-of-god-pertaining-to-jesus-decor-17.jpg. Image Dimension: 800 x 611 pixels. Images Format: jpg/jpeg. Publisher/Author: Anderson Hoppe. Uploaded Date: Tuesday - February 12th. 2019 01:50:28 AM. Category: Coloring Page. Image Source: zillow.com. Is He Plan Resurrection Mr Whats Page Parents Coloring Jesus With To 9. Pertaining Regarding Prepare Risen Decor Has 10. Plans Throughout Easter 16. Pages Word Sunday Of Regard Best Crafting Jellytelly For Crucifixion Twisty In Designs Bible Within 14. 12. Noodle Intended 17. The By Free And 0. 1. Adron God On Printable Kids 4. Decorations Ideas 15.


text:
var assert = require('assert')
  , core = require('nitrogen-core')
  , request = require('request');

describe('permissions endpoint', function() {
    it('index should be not be accessible anonymously', function(done) {
        request(core.config.permissions_endpoint, function(err, resp, body) {
            assert.equal(err, undefined);
            assert.equal(resp.statusCode, 401);
            done();
        });
    });

    it('index should return all permissions', function(done) {
        request({ url: core.config.permissions_endpoint,
                  headers: { Authorization: core.fixtures.models.accessTokens.user.toAuthHeader() },
                             json: true }, function(err,resp,body) {
            assert.ifError(err);
            assert.equal(resp.statusCode, 200);

            assert.notEqual(body.permissions, undefined);
            assert.equal(body.permissions.length > 0, true);
            done();
        });
    });

    it('should allow creating and deleting a permission by a user', function(done) {
        var permission = {
            issued_to:     core.fixtures.models.principals.user.id,
            principal_for: core.fixtures.models.principals.user.id,
            action:        'admin',
            priority:      100,
            authorized:    true
        };

        request.post(core.config.permissions_endpoint,
            { headers: { Authorization: core.fixtures.models.accessTokens.user.toAuthHeader() },
                json: permission }, function(err, resp, body) {
                assert.ifError(err);
                assert.equal(resp.statusCode, 200);

                assert.notEqual(body.permission.id, undefined);

                request.del({ url: core.config.permissions_endpoint + "/" + body.permission.id,
                              headers: { Authorization: core.fixtures.models.accessTokens.user.toAuthHeader() } }, function(err, resp, body) {
                    assert.ifError(err);
                    assert.equal(resp.statusCode, 200);

                    done();
                });
            }
        );
    });

    it('shouldnt allow anotherUser to create a permission on another principal it isnt admin on', function(done) {
        var permission = {
            issued_to:     core.fixtures.models.principals.anotherUser.id,
            principal_for: core.fixtures.models.principals.device.id,
            action:        'admin',
            priority:      100,
            authorized:    true
        };

        request.post(core.config.permissions_endpoint,
            { headers: { Authorization: core.fixtures.models.accessTokens.anotherUser.toAuthHeader() },
                json: permission }, function(err, resp, body) {
                assert.ifError(err);
                assert.equal(resp.statusCode, 403);

                done();
            }
        );
    });

    it('shouldnt allow anotherUser to create a blanket admin permission', function(done) {
        var permission = {
            issued_to:     core.fixtures.models.principals.anotherUser.id,
            action:        'admin',
            priority:      100,
            authorized:    true
        };

        request.post(core.config.permissions_endpoint,
            { headers: { Authorization: core.fixtures.models.accessTokens.anotherUser.toAuthHeader() },
                json: permission }, function(err, resp, body) {
                assert.ifError(err);
                assert.equal(resp.statusCode, 403);

                done();
            }
        );
    });

    it('should allow anotherUser to grant a user view permissions', function(done) {
        var permission = {
            issued_to:     core.fixtures.models.principals.user.id,
            principal_for: core.fixtures.models.principals.anotherUser.id,
            action:        'admin',
            priority:      100,
            authorized:    true
        };

        request.post(core.config.permissions_endpoint, {
            headers: {
                Authorization: core.fixtures.models.accessTokens.anotherUser.toAuthHeader()
            },
            json: permission
        }, function(err, resp, body) {
            assert.ifError(err);
            assert.equal(resp.statusCode, 200);

            done();
        });
    });
});


My Review of Robert Flach's New Book "So You Want to Be a Tax Preparer"
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Read more reviews here and find out why we have a 98.6% approval rating from past students.
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Pronto Income Tax of California, Inc., from which Pronto Tax School, Inc. was born, is a Los Angeles-based tax preparation and consulting company that has been in the tax prep business since 1965. We are a third-generation family-owned and operated company, we operate multiple tax offices in the extremely-competitive Southern California market, and we prepare thousands of tax returns each and every year.
In other words, we don't just talk about this business, we live it for real!
Feel free to review our company history to learn more about our team.
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I had the chance to watch this trailer online a few days after it was released and I had already heard that people were incredibly excited. I have mixed feelings about both the trailer and the film, mainly because, while I liked the first two "X-Men" films, I wasn't thrilled with "X-Men: First Class." I'm not familiar with the Days of Future Past comic book storyline, so I don't know exactly what it entails, and I would have been considerably more enthralled by an Age of Apocalypse film. Being that this is what we have, I think it's worthwhile to try to get into it, and though the trailer includes more unspoken shots of drama and action than actually addresses the plot, it's hard to know just what we'll be in for. The most appealing part of it is the combination of the casts of both the recent reboot and the first three films from the 2000s. Patrick Stewart and Ian McKellen were always a superb pair, and having them come face-to-face, at least at some point, with their younger selves in the form of James McAvoy and Michael Fassbender, seems like a terrific idea. Involving Hugh Jackman's Wolverine in both eras is also fantastic, and I'm hopeful that this will be just what it promises to be – an action spectacular with two magnificent casts side by side. It's not coming out until May, so I'm sure we'll get many more glimpses before then.


Eat lunch or just take a coffee at this café on Hven, Café Tycho. The café serves everything from delicious pies with salad to smoked salmon or sandwiches and baguettes.
Many of the pastries at the café are homemade with ingredients from the Tycho Brahe garden and other locally produced ingredients.