Lot 261 Maps Pre-Grouping Rolled: CLC track plan showing the track layout and signalling at Southport Junction. 24" x 11", part coloured diagram on paper. Undated, punch holes at l/h end, disbound from larger volume. Rolled. - Sold for £60 to bidder number 7310.
Lot 262 Maps Pre-Grouping Rolled: CLC track plan showing the track layout and signalling at Aintree station. 24" x 11", part coloured diagram on paper. Undated, punch holes at l/h end, disbound from larger volume. Rolled. - Sold for £60 to bidder number 7310.
Lot 263 Maps Pre-Grouping Rolled: GNR large rolled book of plans and sections of the proposed Boston deviation produced in 1846. 3pp, some wear. Plus another similar. (2) - Sold for £16 to bidder number 1204.
Lot 264 Maps Pre-Grouping Rolled: EASTERN UNION AND HADLEIGH JUNCTION RAILWAY large rolled book of plans and sections of the proposed extension from Bentley to Hadleigh dated 1845. 7pp, replacement covers. - Sold for £85 to bidder number 342.
Lot 265 Maps Pre-Grouping Rolled: EASTERN UNION RAILWAY large rolled book of plans and sections of the proposed extension from Ipswich to Bury St.Edmunds dated 1844. 18pp, replacement covers. - Sold for £85 to bidder number 342.
Lot 266 Maps Pre-Grouping Rolled: IPSWICH AND BURY ST.EDMUNDS RAILWAY large rolled book of plans and sections of the proposed extension from Bury St.Edmunds to Newmarket & Ely dated 1846. 23pp, replacement covers. - Sold for £85 to bidder number 342.
Lot 267 Maps Pre-Grouping Rolled: NORTH MIDLAND RAILWAY plan of the line through the parish of Wingfield in Derbyshire. Approx 6ft long, 12" wide, part coloured on linen showing line and land ownership. Plus similar, although smaller, plan on paper showing parish of Wingerworth. Undated. (2) - Sold for £55 to bidder number 356.
Lot 268 Maps Pre-Grouping Rolled: GWR large rolled book of plans and sections for additional lands for various locations, produced for the 1865 parliamentary session. 20+pp, wear and faults. - This item was not sold.
Lot 269 Maps Pre-Grouping Rolled: Railway Signal Company plan for the LIVERPOOL OVERHEAD RAILWAY Northern Extension. 30ft to 1", coloured, showing Seaforth station, carriage shed and Alexandra Dock station. 40" x 18" on linen, dated 1893. Folds. - Sold for £100 to bidder number 3451.
Lot 270 Maps Pre-Nat Rolled: GWR coloured plan showing the junctions at Middle Duffryn Sidings, Cwmbach Crossing, Cresselly Crossing and Mountain Ash and instructions to be carried out when flooding occurs. Dated 1946. Plus office copy signalbox diagram for Stonefield dated 1936. (2) - Sold for £18 to bidder number 829.
Lot 271 Maps Pre-Nat Rolled: SR plan of the colour light signalling between Victoria Central and Battersea Park. Coloured plan on linen, 24" wide, very long, dated 1937. - This item was not sold.
Lot 272 Maps Pre-Nat Rolled: SR plan of the colour light signalling between Victoria Eastern and Wandsworth Road. Coloured plan on linen, 24" wide, very long, dated 1937. - This item was not sold.
Lot 273 Maps BR Rolled: BR(W) Signal Engineer's diagram on linen showing signalling at St.Blazey Bridge Crossing. Approx 18" x 16", dated 1961. Plus similar (although larger) 1950 issue. (2) - This item was not sold.
Lot 274 Maps BR Rolled: BR(S) plan of the proposed colour light signalling between Norwood Junction and Bricklayers Arms Junction. Coloured plan, 20" wide, very long, dated 1948. - This item was not sold.
Lot 275 Maps BR Rolled: BR(E) Civil Engineer's Department plan of Tinsley Marshalling Yard. 72" x 16" on paper, dated 1962. Folded, minor faults and wear. - Sold for £12 to bidder number 3732.
Lot 276 Maps BR Rolled: Two privately produced PLANS on linen showing lines in Nottinghamshire and Lincolnshire and the route of the Notts & Lincs Railtour, 12th September 1964. Rolled. (2) - Sold for £70 to bidder number 234.
Lot 277 Maps Non-Railway: GUILDFORD BOROUGH EXTENSION OS type map dated 1933, published by Edward Stanford Ltd. Coloured to show water facilities around Guildford and Woking. Dmf into clothbound hardback covers with title on label on front. - This item was not sold.
Lot 278 Maps Non-Railway: MAIDSTONE WATER OS type map dated 1885. Hand coloured to show River Medway. Dmf into clothbound hardback covers with title on label on front. - This item was not sold.
Lot 279 Maps Non-Railway: DERBY CORPORATION WATER OS type map dated 1899. Hand coloured to show reservoirs south of Sheffield. Dmf into clothbound hardback covers with title on label on front. - Sold for £16 to bidder number 1642.
Lot 280 PTT Sheets: DOVER AND DEAL RAILWAY thin card 12" x 8" timetable for Margate - Shorncliffe and Dover - Deal services. Red and black print, dated October 1888. Grubby and creased. - Sold for £290 to bidder number 249.


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BUILDING SECTOR – Small units are optimistic
Posted on October 25, 2011 by Editor's Desk
Business Standard,
A large majority of small and medium enterprises (SMEs) in the building and construction sector are upbeat about the future and are looking to expand their business.
A large percentage of survey respondents (62.1 per cent) had high expectations of market growth for the next quarter, while 19.7 per cent had low expectations and 18.1 per cent felt there would be no change.
While 76.7 per cent plan to increase their production capacity, only 23.2 per cent said that they did not plan to do so, according to a survey of the building and construction sector carried out by IndiaMART Knowledge Services.
IndiaMART is one of India's largest business-to-business online marketplaces. Around 70.6 per cent of the SMEs wanted to expand their employee base, while 29.5 per cent said that they were not looking to increase employee numbers. More than half of the respondents (54.6 per cent) said that they were planning to increase the number of offices, but 45.5 per cent did not plan to do so.
While the majority of SMEs in the building and construction sector have seen growth, they still continue to reel under different challenges which include poor infrastructure, unskilled manpower, inadequate finance and absence of technology, among others.
Finding unskilled manpower was identified as one of the most difficult challenges by 62.6 per cent of the survey participants. Also, about 54.5 per cent agreed that lack of availability of finance was a major difficulty. The SMEs also identified poor infrastructure (46.9 per cent) and absence of technology (45.9 per cent) as other big impediments.
An overwhelming 90.9 per cent felt that working closely with customers can help them counter challenges and gain a competitive edge, while only 9.1 per cent felt otherwise. About 87.8 per cent of the survey respondents revealed that offering innovative products could give them an edge over competitors, whereas 12.2 per cent did not agree.
About 77.2 per cent wanted additional government support, while 76.3 per cent felt training of labour was also an important consideration. However, investment in information technology is not seen as a major factor that can drive business growth, as only 52.53 per cent were in favour of it.
Expectations for input costs were fragmented — 43.4 per cent of the respondents expected input costs to increase in the next quarter, while 34.3 per cent felt they would come down and 22.2 per cent believed they would remain unchanged.
Around 11.2 per cent of the respondents said the last order they received exceeded `50 lakh, 26.4 per cent said they received orders of between `5 lakh and `10 lakh, and 62.3 per cent said that they received orders worth less than `5 lakh. A thriving infrastructure and real estate sector is the main reason for the growth of SMEs in the building and construction industry.
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Vegetables ›
What is Kimchi
by Jinal Gangar last updated - June 12, 2020
Kimchi or Kimchee is a traditional fermented Korean delicacy, which is made from vegetables like napa cabbage and radishes, and a range of spices and seasonings. These seasonings include pepper, chili powder, garlic, ginger, and scallions. The taste of kimchi is salty and spicy like pickled vegetables and it is used as a side dish in many countries.
It is the national dish of Korea and has been their staple food for ages. There are many varieties of kimchee prepared using different vegetables. There are about 200 variations and the taste of kimchi is customized depending on the season and region you are in.
Origin of Kimchi
The name has been derived from a Korean word 'shimchae' which means 'salting of vegetables'. Later, after going through many phonetic changes the term 'kimchi 'came into the picture and has remained to date. [1]
It traces its origin in Korea around the 7th century. Initially, it was nothing more than just salted vegetables. Gradually, several spices and flavors were added to kimchi, and finally, around 18th-century it was modernized with the introduction of the red hot pepper as a major ingredient. The history of kimchee is rooted in the agrarian culture, which started earlier than the period of the three kingdoms of the Korean peninsula.
A bowl of tangy kimchi Photo Credit: Shutterstock
Cabbage, kimchi
Serving Size : 100 g1 cup (150 g)
Water [g] 94.3
Energy [kJ] 65
Protein [g] 1.1
Total lipid (fat) [g] 0.5
Ash [g] 1.7
Carbohydrate, by difference [g] 2.4
Fiber, total dietary [g] 1.6
Sugars, total including NLEA [g] 1.06
Calcium, Ca [mg] 33
Iron, Fe [mg] 2.5
Magnesium, Mg [mg] 14
Phosphorus, P [mg] 24
Potassium, K [mg] 151
Sodium, Na [mg] 498
Zinc, Zn [mg] 0.22
Copper, Cu [mg] 0.02
Selenium, Se [µg] 0.5
Thiamin [mg] 0.01
Riboflavin [mg] 0.21
Niacin [mg] 1.1
Vitamin B-6 [mg] 0.21
Folate, total [µg] 52
Folate, food [µg] 52
Folate, DFE [µg] 52
Choline, total [mg] 15.5
Vitamin A, RAE [µg] 5
Carotene, beta [µg] 55
Carotene, alpha [µg] 1
Vitamin A, IU [IU] 93
Lutein + zeaxanthin [µg] 49
Vitamin E (alpha-tocopherol) [mg] 0.11
Vitamin K (phylloquinone) [µg] 43.6
Fatty acids, total saturated [g] 0.07
12:0 [g] 0
16:0 [g] 0.06
Fatty acids, total monounsaturated [g] 0.04
Fatty acids, total polyunsaturated [g] 0.24
18:2 [g] 0.1
Sources include : USDA [2]
Attributing to the extremely cold weather which made the cultivation practically impossible, Koreans had to come with a storage method called 'pickling' to secure food.
Kimchee was also taken to space by astronauts on the spaceship. The multi-million dollar research conducted on it took several years and was aimed at achieving a version of kimchi which would remain harmless and bacteria-free even after exposure to cosmic radiations and remain safe for consumption. [3]
Even after so many alterations and additions were done in its ingredients over the centuries, this Korean appetizer is still prepared using the same cooking method and has still retained the same qualities and benefits as it used to be when first introduced. [4]
Types of Kimchi
The most commonly relished varieties are:
Baechu kimchi – Made from Napa cabbage
Baek kimchi – White kimchi without a chili pepper
Kkakdugi kimchi – Made with Korean radish containing fermented shrimp
Chonggak kimchi – Prepared with ponytail radish
Oi sobagi – Cucumber kimchi enjoyed during summer and spring
With so many types available, it deserves to be on the list of 'World's Healthiest Foods'. And it comes as no surprise that the natives of Korea love it, so much that they say 'kimchee' instead of 'cheese' while getting clicked.
http://www.nytimes.com/2008/02/24/world/asia/24kimchi.html?_r=0
https://www.researchgate.net/publication/286043007
https://doi.org/10.1016/j.jef.2015.08.005
Jinal, an ex-banker who has completed her MBA in finance from Mumbai University, is passionate about health and wellness. She is a social media enthusiast. She has completed an online program on "Introduction to Food and Health" from Stanford University, US. On weekends you can find her in cafes or movie theaters. Positivity drives her and she finds peace in cooking, reading, and coffee!


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You are here: Home / Championships / GT – Davide Rigon draws attention on himself at Navarra
GT – Davide Rigon draws attention on himself at Navarra
18 October 2012 /in Championships /by Redazione
In the final racing weekend of Blancpain GT Endurance Series which took place at the Spanish circuit of Navarra, Davide Rigon drew attention on himself by keeping a top driver pace and leading his Ferrari 458 to the second place, before yielding the wheel to his team mate Gattuso.
Two years after winning the Superleague Formula Championship for the second time, the talented Italian driver is now ready to go back to the Spanish track behind the wheel of his Ferrari 458. In a cool and rainy Sunday, Davide took the lead of the car during the second hour of the race and soon managed to get up to the 2nd position, next to McLaren.
When the rain was getting harder and harder and the race was getting into the final part, Rigon had to pit to change tyres and yielded the wheel to his team mate. Due to heavy rain, the track was impracticable, so the race director decided to stop the race a little bit in advance, just after the safety car dominated the track for a long time.
" It was a good weekend, I like the Navarra circuit so much. Last time I raced here was in 2010, when I won the Superleague Formula Championship for the second time. We handled a good race since qualifying and during the race I managed to get up to the 2nd position under a rainy weather, and got next to the McLaren. As rain was getting harder and harder, we decided to pit and that was the moment I yielded the wheel to my team mate. It was a hard season and the Championship was very selective. I want to thank Kessel Team for giving me such a great opportunity."
With the race at Navarra, Davide Rigon' first racing season in the GT Blancpain Endurance Series ends up. It's a magnificent Series in which more than 50 cars were involved throughout the six venues scheduled for the Championship.
Redazione http://www.minardi.it/wp-content/uploads/2019/07/logo_m-1.png Redazione2012-10-18 14:25:272019-10-23 00:35:17GT – Davide Rigon draws attention on himself at Navarra
F.3 – Nicholas Latifi ready for the final race in Monza F.3 – At Monza Latifi finishes a racing season during which he has so much...


The Caisson platoon of the 3rd U.S. Infantry "The Old Guard" have the honor of carrying a comrade for his last ride to Arlington National Cemetery where he will rest in peace with other honored dead.
The Old Guard honor one of their own.
Six horses, matched gray or black, pull the caisson through the quiet lanes of Arlington National Cemetery.
A full-honor funeral, allowed for a soldier or Marine in the rank of colonel or higher, includes the caparisoned horse. The horse is led behind the caisson wearing an empty saddle with rider's boots reversed in the stirrups, indicating the warrior will never ride again.
On a visit to Arlington, Virginia, you can tour the stables, pet the horses and see up close how The Old Guard soldiers and horses train and prepare constantly for this solemn duty.


Smoke and Mirrors, or Refuse to Give Up!
This fall started out with great promise, with some key seniors replacing graduation losses; and coming off of a very successful 2015 season! Yet, with the academic pressure of senior year; and injuries to no less than four starters – the boys soccer program had to be 'redesigned'! They became the youngest varsity group in the area, with five eighth graders playing on the varsity! The girls also came to the aid of the program by providing experience and leadership. The team played the schedule as a 'coed' program! Adding to that a rash of cancellations, from schools dropping teams to weather events; and this became a very 'unique' season!
In spite of this, the boys rallied around goalie Sam Levine, and defenders Jake Payne, Tucker Pauli, and Grayson Early. They built a young, energetic midfield of Finn Doering, Samson Orlinsky, Monte Chetkof, Eli Propper, and Lucca Lofaro; complimented by the offense of Hudson Price! This youthful offensive group helped account for 35 goals on the season, quite impressive for a group of 8th and 9th graders! With help from the girls program, the boys fought their way to a 4 – 4 .500 record! In the process they managed to out score their opponents 35 – 24! This was the 'smoke and mirrors' which surprised all of their opponents! What great potential for the future, as no one graduates!
In contrast, the girls just 'kept on winning'! With the leadership of goalie Casey Hall, and juniors Kendall Wind, Hazel Dunning, Layla Michalopoulos, and Ruby Nagelberg; the girls took credit for a second consecutive undefeated season! With the support of Sophie Levy, Tonya DeChar, and the incredible ninth graders Starllie Swonyoung, Lola Cook, and Lily Brady; the girls gelled as a force among their rivals! Add to this the efforts of Ellie Zur, Cally Mansfield, and Dora Wilt; and our girls produced a 7 – 0 – 1 record; while outscoring their opponents 35 – 9! Their combined two year record is 12 – 0 – 3! They are regarded as one of the best girls teams among the small preps of the Hudson Valley! Kudos! And only Casey graduates!
The 5/8th team, under the coaching of Brandon Harkin, amassed a very respectable 5 – 3 record! With experienced players Alex Ober, Zach Zabriskie, Niko Poort, and Ben Fox, they played again in the Dutchess Day seven – a – side tournament! Jerome Martindale, Ollie Milford, Eve Riskind, and Shannon Leiching were supported by younger players Jack Barker, Harry Thomter, Marly Lofaro, Owen Koelmel, Levi Koelmel, Jackson DeVito,Sam Leon, and Harrison Hughes.This group outscored their opponents 41 -24; and the 7th grade looks to have a brilliant future as they move up to the boys program next year!
The combined record of these three teams is 16 – 7 – 1! Considering the obstacles overcome, injuries suffered, and opponents dropped seasons; this was a remarkable accomplishment! The fact that there is only one senior leaving the soccer program creates anticipation for the future! WDS soccer is alive and well!
While the cross country program was hit by sickness and 'senior-itis', Sasha Mancuso continued to run with coach Roy Verspoor throughout the Fall. Finally, joined by returning teammates Max Cohen and Will Cullen, they managed a run in the 'HVAL Division Championship' on Nov.9th in Poughkeepsie. Max won a medal for his 6th place finish in the 10th grade race; Will took a third place in the 11th grade run, and to his credit; Sasha WON his boys senior division race! A fitting finish to Sasha's running years at WDS; and the event that saved our Cross Country program! Here's to the future, WDS Harriers!


Nowadays people are combining antique and the modern innovative bath vanities features, furnishings and fittings to renovate their bathrooms in to frill personal retreats. Items such as bathroom vanity cabinets, paintings and even plants are now becoming mutual place among-st the furniture within the confines of the bathroom. This not only helps to make the space more tempting but it combines suitability with relaxation.
In statistic home owners are now becoming fashion aware towards the interior styling of their bathrooms. Creative materials and antique bathroom vanities color patterns mixed with modern features are now energetic components for the bathroom. It does not end there; interior designers are nowadays earning massive amounts of money from people wanting to create a whole new look to any bathroom. Vintage bathroom vanities manufacturers are also flattering much more creative with their variation of bath products, all to see the difficulties of home owners throughout the world.
The selection of vintage bathroom vanities cabinets and accessories is vast taking on many exclusive and dissimilar forms from practical bath furniture like the bathroom vanity to the more chic elements such as bathroom vanities sets, well-lit mirrors right up to the well-appointed steam showers and baths. The only problem to overwhelm is to know what pieces of bath furniture will best suite your present inner.
There is nothing quite as discerning than adding a few stylish pieces of bathroom furniture to your existing décor to then find that your elegant look has just clashed and now looks cluttered and at worse unsightly.
It can seem to be really difficult knowing what vanities, countertops and sinks will go with what without first assimilating them together. But it is wise to take life-threatening consideration as to whether the bath product you are searching for will balance your existing bathroom. A boundless way to start is to simply check out the things your current interior involves of. For instance if your interior features a certain sort of bath vanities woods, countertops and vessel sinks then obviously the safest option is to go for more to modern bathroom vanities design. Or look at what mirrors will look noble beside your existing antique bathroom vanity cabinets.
Your bathroom situation is themed on an antique, traditional or modern bathroom vanities ambiance the new or latest designs are definitely shaped to make it ample easier for vanities to be combined in to any bathroom.
This entry was posted in Antique Bathroom Vanities, Contemporary Bathroom Vanities, Discount Bathroom Vanities, Modern Bathroom Vanities, Traditional Bathroom Vanities, Vanities for Bathroom, White Bathroom Vanities and tagged Antique and the Modern innovative bath vanities. Bookmark the permalink.


The old school style of these leather trainers is made for walking. The low-cut design elevates your sophistication score. And you never have to skimp on comfort with the EVA midsole and removable sockliner that accommodates orthotics. The stitched logo adds a touch of detail. Make this classic look last with the durable rubber outsole. You'll never want to take these trainers off.


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Press Gazette's submission to Government consultation on Official Secrets Act reforms
Ronan Keating wins News of the World phone-hacking payout over 15 years of 'suspicious' stories
News diary 26 July-1 August: Chris Whitty assault accused in court and full capacity Proms return to Royal Albert Hall
By Foresight News Twitter
Foresight News rounds up the key events that need to be in your news diary this week…
Monday 26 July
The UK's COP26 President Alok Sharma wraps up a two-day ministerial meeting for discussions on outcomes at the UN climate summit in Glasgow this November. Against the backdrop of soaring summer heatwaves across the globe, most recently in North America, the November meeting is the most important political conference on climate change since the Paris agreement was inked in 2015. Last week, more than 100 developing countries set out their negotiating demands, saying COP26 "needs to be a summit where we see action, not words", and that major economies need "to start delivering on their promises."
News diary 31 January - 6 February: Liz Truss visits Ukraine, Winter Olympics open and Sue Gray report awaited
News diary 24-30 January: Assange judgment, Downing Street investigation results and 'Plan B' measures end
News diary 17-23 January: Australian Open begins and Sue Gray finalises parties investigation
A pre-inquest review hearing takes place as part of the investigation into the 2015 Shoreham Airshow disaster, which claimed the lives of 11 people. A hearing last month ruled that the full inquest will now be delayed until February next year, pending a High Court decision on access to certain materials. The inquest was initially scheduled to take place this October, having already been delayed for 12 months because of the coronavirus pandemic.
Olympic highlights: Swimming dominates the day with the finals of the women's 100m butterfly, men's 100m breaststroke (Adam Peaty may race), and the men's and women's freestyle.
Former Health Secretary Ken Clarke appears before the Infected Blood Inquiry on the opening day of a week-long evidence session. Clarke's evidence presents something of a landmark moment for the inquiry; previous hearings have seen him accused of "deliberately peddling false information" relating to the scandal during his time in charge of the Department for Health. Questions will further explore allegations of a government cover-up of the scandal, which saw thousands of NHS patients receiving contaminated blood treatments throughout the 70s and 80s.
The US House of Representatives' Select Committee to Investigate the January 6 Attack on the US Capitol holds its first hearing, featuring testimony from law enforcement officials on duty that day. Though intended to be bipartisan, the committee features just one Republican, Trump critic Liz Cheney. All other Republicans are boycotting the investigation after Speaker Nancy Pelosi rejected the participation of two Congressmen who supported efforts to undermine the results of the election.
Olympic highlights: Medals are awarded in the team dressage, men's and women's rowing, and women's softball.
Boris Johnson and Kenyan President Uhuru Kenyatta co-host an international high-level summit on access to education around the globe. The summit comes as evidence suggests the COVID-19 pandemic has worsened the global education crisis, with 1.7 billion children experiencing disruption at the peak of school closures. Ahead of the summit, Johnson pledged £430m for girls' education as part of the UK's contribution to the Global Partnership for Education, for which the host nations hope to raise £5bn over the two days in London.
Olympic highlights: Finals of the men's and women's individual time trial cycling, the individual dressage, and the men's and women's butterfly swimming.
Housing Minister Christopher Pincher is due to issue a decision by today on the planning application for the Holocaust Memorial and Learning Centre, following the submission of a planning inspector's report into the project on 29 April. The application was called in after being rejected by the local council amid opposition to its location at Victoria Tower Gardens and fears that it could become a target for terrorism. The memorial is due to open in 2024 if planning permission is granted.
A week after the UK saw roads "melt like chocolate" during the stifling heatwave that swept across the country, The Met Office publishes its annual report into the UK climate. Last year's report identified 2019 as the 12th warmest year on record in the UK, including a new all-time high when temperatures reached 38.7 degrees that July. While 2020 didn't set any records for heat, the Met Office says it does feature in the Top 10 for the warmest, sunniest and wettest years on record, something they attribute to human-caused climate change.
Olympic highlights: Men's and women's pairs take to the water in rowing finals, and Simon Biles likely competes in the final of the women's all-round individual gymnastics.
Two men are due before magistrates in Westminster charged with common assault over an incident involving England's Chief Medical Officer Chris Whitty (pictured). Lewis Hughes and Jonathan Chew are accused of accosting Whitty as he walked through St James' Park on 27 June. Prime Minister Boris Johnson described the incident as "despicable", with Health Secretary Sajid Javid and Home Secretary Priti Patel also lending their support to Whitty soon after.
Classical music lovers descend on the Royal Albert Hall for the start of the Proms season. Despite the spike in coronavirus cases, this year's festival takes place at full capacity, a stark contrast to the 14 concerts performed to an empty hall last year. The sense of normality extends to the programme, which features the return of Rule, Britannia! and Land of Hope and Glory sung in full on the final night.
Olympic highlights: First major athletics event comes with the running of the men's 10,000m, and medals are also awarded in BMX racing and eights rowing.
NHS England chief executive Sir Simon Stevens steps down after seven years in the role. The organisation's new boss, to be chosen by the NHS board and new Health Secretary Sajid Javid, will assume the role at a pivotal time for the health service; the backlog of operations and appointments stands at around five million, with that number expected to double in the next few months. The new chief executive is also likely to have their independence curbed due to health legislation placing greater power in the hands of ministers as well as having to contend with the government's decision to fund a three per cent staff pay rise from within the NHS budget.
Pensioners face the prospect of enforcement for not paying their TV licence fee as the grace period for non-payment comes to an end. The transition period began after the free licences for over-75s were scrapped in in August 2020, with more than a quarter of a million pensioners having failed to pay for their licence as of last month.
The hotly anticipated Olympic women's 100-metre final sees Team GB's Dina Asher-Smith attempt to beat Jamaica's Elaine Thompson-Herah and Shelly-Ann Fraser-Pryce, who recently became the world's second-fastest woman of all time. The race has drawn an unusual amount of attention, in part due to the controversial suspension of 21-year-old American Sha'Carri Richardson. A favourite to win gold, Richardson was banned for a month following a positive marijuana test.
Sunday 1 August
The cost to employers of keeping staff on furlough increases from today as the government grant in the Job Retention Scheme is reduced to 60 per cent of wages. The furlough scheme has been one of the pillars of Chancellor Rishi Sunak's economic support packages since the pandemic began, with over £65bn spent on the scheme to the end of May this year. The Labour Party and unions have warned that many businesses could struggle to meet the additional costs, with employers expected to pay national insurance and pension contributions from this month on top of the wage top-ups.
The men's 100-metre final takes centre stage at Tokyo on Sunday as a crowded field jostles to succeed Usain Bolt as Olympic champion. As athletics looks for its newest sprint sensation, American duo Noah Lyles and Trayvon Bromell seem best placed to clinch the gold – fans hoping for a fairy-tale win though need look no further than Canada's Andre De Grasse.
The news diary is provided in association with Foresight News.
Picture: Daniel Leal-Olivas/PA Wire


Visit our partner store, Delphine's Flower Bead Shop for their entire line of Lucite Flower Beads for the every day beader, all at unbeatable prices! There you will find all the Lucite flowers, Lucite leaves, West German Lucite, and more that anyone that loves Lucite will be crazy for!
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Ever wondered how to create a dashboard in Jira? You can create your own dashboard or share a dashboard with your team by adding permissions for specific users, groups or project roles to access your dashboard. The first step will be to create a filter. The filter will be specific information you may require. Dashboards work well if you need a specific view or information on a certain project.


Copper preparations had back to the mainstream of sterilization because of its no-drug resistance.Hence,we developed supported nano original pesticide,including nano material and carrier, specially for making copper preparation,which is added and no need to add again when prepare post-copper complex formulation.With nano material characteristics of macro effect,quantum tunneling effect and surface effect,this products have advantage of strong bactericidal power,higher suspension rate,stronger ahension,and longer duration of action.Combining with nano technology can greatly improve the quality of copper preparations.
Supported nano copper oxide nanowires contains nano copper chloride basic and carrier,withdiameter of 60-100nm,light green powder.Insoluble in water and organic solvents,soluble in ammonia and acid,stable in the air.
Supported hydroxide nanowires contains nano copper hydroxide and carrier,with diameter 40-80nm,length 1-2μm.Light blue or blue powder,insoluble in water but soluble in acid and ammonia.
Supported copper sulfate basic contains nano basic copper sulfate and carrier,with thickness of 10-50nm,length 1-2μm.Green or light green powder,soluble in water.
Supported nano copper oxide contains copper oxide nanowires and carrier with diameter of 40-60nm,length 1-2μm.Brown or black powder.
"Pesticide is the basis of agricultural security and stability of guaranteeing agricultural production. But because the traditional pesticide with poor dispersion, bad deposition, low biological activity , slow degradation and other reasons, the target crop utilization of less than 30% and the pest accept inadequate doses of 0.1%, resulting in pesticide residues, environmental pollution, destruction of biodiversity, ecological degradation and other issues. Therefore, breaking the bottleneck of the development of pesticide industry, researching and developing green pesticides has become a major national strategy. Many countries put more importance on developing nano technology besides on studying bio-pesticides. "Cui Haixin,scientist of nano pesticides "973" project,said.
Modern pesticides is the foundation and prerequisite of modern agriculture, our company take the lead in developing nano-original pesticide series,which can greatly improve the quality of copper preparations, and reducing usage amount and residues.Do our best to protect people's health and the world environment.


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text:
Zakrjow ist der niedersorbische Ortsname von:

 Sacrow, Ortsteil der Gemeinde Spreewaldheide
 Türkendorf, Ortsteil der Stadt Spremberg

redpajama_set_name: RedPajamaWikipedia


text:
Saosjornaja (russisch ) ist der Name folgender Dörfer in Russland:
 Saosjornaja (Kurgan, Kargapolje), in der Oblast Kurgan, Rajon Kargapolje
 Saosjornaja (Kurgan, Wargaschi), in der Oblast Kurgan, Rajon Wargaschi
 Saosjornaja (Omsk), in der Oblast Omsk
 Saosjornaja (Tjumen), in der Oblast Tjumen

Siehe auch:
 Saosjornoje (Begriffsklärungsseite)
 Saosjorny (Begriffsklärung)


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If you are on the prowl for a way to keep purses, backpacks and more nice and organized, you won't want to miss today's sewing tutorial from PS contributor Megan. These see-through zipper pouches are a great organization project that can be used for any number of purposes, and you'll be shocked when you see how easy they are to stitch up. And, with back-to-school time just around the corner (believe it or not!) sewing these would be a great way to prepare for the school year to come. Take it away, Megan!
Hi Everyone! This is Megan, visiting today from The Homes I Have Made, with a really fun, quick, and easy sewing project! Don't let the zipper and the bias tape in these cute little purse pouches scare you away – I promise, these are easier than you think. Plus, they come together in a jiffy; are great for using up scraps and extra notions you might have laying around the house; AND can be used in all sorts of ways to keep your purse, diaper bag, backpack (or anything!) tidy and organized!
In addition to the clear vinyl front and zipper access (making it super easy to see and grab what's inside!), my favorite part of these little pouches is that you can use two coordinating fabrics on the front and back to give them an extra dose of cuteness!
Here's what you need to whip up your own pouches!
Start by cutting ONE of your prints down to a 9″x9″ square. Do the same with your Heat'n'Bond. Don't bother measuring/cutting your second fabric, we'll get to it in the next step!
Next, you're going fuse your two fabrics together using the Heat'n'Bond.
a) Iron your Heat'n'Bond (paper side up) onto the WRONG side of your other fabric.
b) Remove the paper backing from the Heat'n'Bond.
c) Iron your 9″ square of coordinating fabric (RIGHT side UP) onto the area that has the Heat'n'Bond.
With your two fabrics secured, wrong sides together, cut out the 9″ square with a scissors, using the top square as your guide (bottom left). When you're done with this step, you should have a 9″ square with patterned fabrics facing out on both sides (bottom right)! Set this square aside.
Next, cut the vinyl into two rectangles, each measuring 4.5″x8″.
Now it's time to install the zipper. Don't panic – this is going to be a lot easier than you think!
a) Pin the zipper (FACE DOWN) onto one edge of the vinyl (keep thinking: wrong sides together).
b) Using a zipper foot, sew the vinyl to the zipper as close to the zipper teeth as you can get.
c) Flip the zipper right-side-up and fold/bend the vinyl open, just like you would with a fabric seam.
Next, to help the vinyl/zipper lay flat, top stitch back down the length of the zipper (still using your zipper foot), right next to (or on top of) your original line of stitching.
Now it's time to bring your two squares together!
Decide which fabric you want to face up (as in, through the vinyl window) and place it facing you on your work surface. Next, center your zipper/vinyl square onto the fabric square RIGHT SIDE UP (as in, the zipper pull should be out facing you). Pin the two squares together to hold everything in place (bottom left). Using a scissors, trim the excess fabric around the vinyl square to ensure you have matching edges all the way around.
Since vinyl is too bulky to sew/flip right-side-out/press, as you would a normal seam with fabric, we are going to sew the two squares together and finish the edges all in one step using bias tape. Simply pin your bias tape all the way around the square, with the edges of the square tucked all the way up inside the fold of the tape. If you used my same measurements, the bias tape should come right down to the zipper stops (bottom left). When you get back to the beginning, you can sew your bias tape together the fancy way (bottom right) or just fold your ends under and sew one on top of the other.
Here's the pouch with the bias tape pined down all the way around, ready for sewing. To keep my corners clean, I folded the bias tape at 90 degree angles instead of easing it around the bends (which would result in a more circular shape in the end). I found this quicker, easier, and cleaner, but to each his/her own 🙂 You could also miter your corners if you have the patience!
…just un-zip and fill the pouch with all those things that fall to the bottom or your purse/diaper bag, in my case: snacks, gum, a pen, and Chapstick!
Other items I am constantly fishing out of my purse are cars for my Cars-loving two-year-old. We can't go anywhere without one (or five!). To keep them corralled and at the ready, I made a special pouch to hold Lightening McQueen and his friends!
I'm kind of addicted to making these, as I can now think of a million uses for them. And what a fun way to use up some of my fat quarters and notion leftovers from other projects! Most of all, I love that they are a fun and cute way to keep my purse organized–no more digging around for a piece of gum or whatever else I may need at a moment's notice!
Hope everyone is having a great summer! See you back here soon next month!!
Thanks for this tutorial. I am definitely going to make one for my purse, but I also need to make one for another reason. Hubby and I are planning on going to a pro football game this year, and the NFL has banned standard sized purses from all stadiums. A small clutch no larger than a person's hand is OK. A large freezer bag passes, too. But anything else must be made of a clear material, such as plastic, and must not be larger than 12 x 6 x 12. I will be making one of these to take with me to the game!
Great tip, Sandy! These will work perfectly for that. Enjoy the game!!
It's times like these I wish I could sew. I need these so badly! What a great idea, they are SO cute!
Amanda check with your nearest school, the students might like these and might make you one, if not e-mail me and I'll make one for you.
Great zip bag. Do you have a pdf that I can save?
Cute and practical! It'll be great for beach too.
These would be great in any size, especially when traveling through busy airport security checkpoints. It would have saved me so much frustration zipping and unzipping small bags in my luggage for the searches! Great instructions, BTW. One question?… I noticed you used NO-SEW adhesive, at least in the picture, did you find it gums up your needle at all?…I've always been scared to use it…even though it is usually the strongest!
very good project see-through zipper pouch, since my sewing studio is organized with see through items where everything can be seen, why not keep my purse organize too, thank u very much for a cute sewing idea.
I'm going to make mine a bit larger…say 12×12 and add a couple of "puckers/gathers" to each side…in order to make the inside have a bit more room…otherwise you can only fit flat items in these!
I love this project. I think I'll go work on one, but I was thinking of making it 2 sided, by putting a second sheet of plastic and zipper on the other side of the fabric. Thanks for the tutorial.


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redpajama_set_name: RedPajamaGithub


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Tag Archives: Hollywood
Snow Above Los Angeles (Feb 2019)
The winter storm of the past few days is over, leaving a thick coat of snow on the higher parts of the San Gabriel Mountains and a thin dusting on the lower parts, even the mountains behind the Hollywood Hills, still lingering though mid-morning.
By mid-afternoon, most of the snow in the second photo appeared to have melted, and the patches on Mt. Wilson (barely visible to the left in the first and third images) had mostly faded. The next ridge back was still thoroughly covered, though!
I left work just before sunset, to make sure I could get some photos of the reddish light glinting off of the still snow-covered mountains.
This entry was posted in Photos and tagged Hollywood, Los Angeles, San Gabriels, snow on February 6, 2019 by Kelson.
Ah, Hollywood Accounting!
The Los Angeles Times is reporting that Dreamworks and Aardman are going their separate ways after the disappointing performance of Flushed Away and Wallace & Gromit: Curse of the Were-Rabbit.
Wait… Wallace and Gromit? Wasn't it #1 on opening weekend? Didn't it stay in the top 5 for at least a month?
Aardman's dry British wit went over well with critics on such films as "Chicken Run" in 2000 and 2005's "Wallace & Gromit: The Curse of the Were-Rabbit," which won an Oscar for best animated feature.
But both "Wallace & Gromit" and "Flushed Away" were costly misfires, failing to resonate with American audiences. DreamWorks reported a $25-million loss on "Wallace & Gromit."
Hmm, according to IMDB, W&G had an estimated budget of $30 million. It grossed $16 million its opening weekend and went on to gross $56 million by January, 2006. Domestically. That's not even counting foreign distribution or DVD sales.
If they spent $30 million and made more than $56 million, how exactly did they "lose" $25 million? Where did that missing $50 million go?
This entry was posted in Entertainment and tagged Aardman, accounting, Dreamworks, Hollywood, movies on January 31, 2007 by Kelson.
Mary Shelley's Bride of Frankenstein
I've been working my way through the classic Universal Frankenstein movies, some of which I'm sure I've seen before, and some of which I'm sure I haven't. Of course, they get filtered through having read the book at least three times and having watched Young Frankenstein many times.
Last weekend I watched Bride of Frankenstein. It's a good movie, but the framing sequence bugs me. In it, Lord Byron is telling Mary Shelley how much he enjoyed her tale of horror, and proceeds to revisit the high points in the 1935 version of "Previously, in Frankenstein…" Unfortunately, just about everything he mentions wasn't in her book! (Neither the 1818 or 1831 versions.) He then bemoans that it should have ended so abruptly, at which point she says something like, "Ended? That wasn't the end at all!" and proceeds to tell Percy Shelley and Lord Byron the tale of, well, the next movie.
All this, despite the fact that the movies clearly take place in the 20th century, though they at least went to the effort to dress Byron and the Shelleys in period costumes.
On one hand, it's a nifty conceit, made somehow more appropriate by casting the same actress, Elsa Lanchester, as both Mary Shelley and the Bride.
On the other hand, it's emblematic of Hollywood's mixed demand and contempt for original source material and its authors. This is the industry that brought us both Bram Stoker's Dracula and Mary Shelley's Frankenstein, trading on the author's name as a claim of authenticity while still taking things in their own direction. (To be fair, both movies made efforts to include aspects of the original stories that are usually left out. And MSF followed quite well until about 5 minutes before the end, at which point it took a 90° turn and flew off into another movie entirely.)
Neil Gaiman says it best in his short story, "The Goldfish Pool and Other Stories" (in Smoke and Mirrors):
She managed a pitying look, of the kind that only people who know that books are, at best, properties on which films can be loosely based, can bestow on the rest of us.
This entry was posted in Sci-Fi/Fantasy and tagged authors, Frankenstein, Hollywood, horror, movies, scifi on September 11, 2006 by Kelson.
Reality TV and Remakes
On seeing an ad for the upcoming Dukes of Hazzard movie, I started thinking of other 70s and early 80s TV shows that Hollywood might remake. Then I started thinking of late 80s and 90s shows. I'm certain that, 10-20 years from now, there will be a Beverly Hills 90210 movie.
But what about the big hits of this decade—the reality shows? Will Hollywood want to release Survivor or Fear Factor movies for 2025? Or would it be like producing a Jeopardy movie?
One of the big draws for shows like Survivor or American Idol is watching the contestants' stories unfold over time. You can't do that in a two-hour movie as effectively as you can over a 10–20–week season. On the other hand, not every reality show is about the long haul. Assuming the public's taste doesn't change, I'm sure Fear Factor could be made into a movie. (Though one could argue that it already has been.)
Later in my drive I heard a story on the radio about Iraqi reality TV. Apparently the genre has become quite popular there, particularly the helpful sub-genre (like Extreme Makeover: Home Edition). There's a show that helps people navigate government bureaucracy, a show that rebuilds homes destroyed in the war, one that gives couples dream weddings, one that takes people to foreign hospitals for medical procedures, etc.
Who knew what else we'd be exporting?
This entry was posted in Entertainment, Politics and tagged Hollywood, Iraq, reality, remakes, TV on July 12, 2005 by Kelson.


Companies that were sued over contaminated pet food have agreed to a settlement of $24 million.
Atlas: SETTLEMENTS EXPLAINED!! New War System, New Claim System, New Upkeep System, & MUCH MORE!
"Petrousha" is a classical Russian cuisine restaurant, located in the historic building of the former Horse Life Guards Regiment barracks of St Petersburg, Russia.


text:
Structural stability and functional remodeling of high-density lipoproteins.
ABSTRACT: Lipoproteins are protein-lipid nanoparticles that transport lipids in circulation and are central in atherosclerosis and other disorders of lipid metabolism. Apolipoproteins form flexible structural scaffolds and important functional ligands on the particle surface and direct lipoprotein metabolism. Lipoproteins undergo multiple rounds of metabolic remodeling that is crucial to lipid transport. Important aspects of this remodeling, including apolipoprotein dissociation and particle fusion, are mimicked in thermal or chemical denaturation and are modulated by free energy barriers. Here we review the biophysical studies that revealed the kinetic mechanism of lipoprotein stabilization and unraveled its structural basis. The main focus is on high-density lipoprotein (HDL). An inverse correlation between stability and functions of various HDLs in cholesterol transport suggests the functional role of structural disorder. A mechanism for the conformational adaptation of the major HDL proteins, apoA-I and apoA-II, to the increasing lipid load is proposed. Together, these studies help understand why HDL forms discrete subclasses separated by kinetic barriers, which have distinct composition, conformation and functional properties. Understanding these properties may help improve HDL quality and develop novel therapies for cardiovascular disease.
Correlation of structural stability with functional remodeling of high-density lipoproteins: the importance of being disordered.
Project description:High-density lipoproteins (HDLs) are protein-lipid assemblies that remove excess cell cholesterol and prevent atherosclerosis. HDLs are stabilized by kinetic barriers that decelerate protein dissociation and lipoprotein fusion. We propose that similar barriers modulate metabolic remodeling of plasma HDLs; hence, changes in particle composition that destabilize HDLs and accelerate their denaturation may accelerate their metabolic remodeling. To test this notion, we correlate existing reports on HDL-mediated cell cholesterol efflux and esterification, which are obligatory early steps in cholesterol removal, with our kinetic studies of HDL stability. The results support our hypothesis and show that factors accelerating cholesterol efflux and esterification in model discoidal lipoproteins (including reduced protein size, reduced fatty acyl chain length, and/or increased level of cis unsaturation) destabilize lipoproteins and accelerate their fusion and apolipoprotein dissociation. Oxidation studies of plasma spherical HDLs show a similar trend: mild oxidation by Cu(2+) or OCl(-) accelerates cell cholesterol efflux, protein dissociation, and HDL fusion, while extensive oxidation inhibits these reactions. Consequently, moderate destabilization may be beneficial for HDL functions by facilitating insertion of cholesterol and lipophilic enzymes, promoting dissociation of lipid-poor apolipoproteins, which are primary acceptors of cell cholesterol, and thereby accelerating HDL metabolism. Therefore, HDL stability must be delicately balanced to maintain the structural integrity of the lipoprotein assembly and ensure structural specificity necessary for interactions of HDL with its metabolic partners, while facilitating rapid HDL remodeling and turnover at key junctures of cholesterol transport. The inverse correlation between HDL stability and remodeling illustrates the functional importance of structural disorder in macromolecular assemblies stabilized by kinetic barriers.
Protein Backbone and Average Particle Dynamics in Reconstituted Discoidal and Spherical HDL Probed by Hydrogen Deuterium Exchange and Elastic Incoherent Neutron Scattering.
Project description:Lipoproteins are supramolecular assemblies of proteins and lipids with dynamic characteristics critically linked to their biological functions as plasma lipid transporters and lipid exchangers. Among them, spherical high-density lipoproteins are the most abundant forms of high-density lipoprotein (HDL) in human plasma, active participants in reverse cholesterol transport, and associated with reduced development of atherosclerosis. Here, we employed elastic incoherent neutron scattering (EINS) and hydrogen-deuterium exchange mass spectrometry (HDX-MS) to determine the average particle dynamics and protein backbone local mobility of physiologically competent discoidal and spherical HDL particles reconstituted with human apolipoprotein A-I (apoA-I). Our EINS measurements indicated that discoidal HDL was more dynamic than spherical HDL at ambient temperatures, in agreement with their lipid-protein composition. Combining small-angle neutron scattering (SANS) with contrast variation and MS cross-linking, we showed earlier that the most likely organization of the three apolipoprotein A-I (apoA-I) chains in spherical HDL is a combination of a hairpin monomer and a helical antiparallel dimer. Here, we corroborated those findings with kinetic studies, employing hydrogen-deuterium exchange mass spectrometry (HDX-MS). Many overlapping apoA-I digested peptides exhibited bimodal HDX kinetics behavior, suggesting that apoA-I regions with the same amino acid composition located on different apoA-I chains had different conformations and/or interaction environments.
ApoA-I-Mediated Lipoprotein Remodeling Monitored with a Fluorescent Phospholipid.
Project description:We describe simple, sensitive and robust methods to monitor lipoprotein remodeling and cholesterol and apolipoprotein exchange, using fluorescent Lissamine Rhodamine B head-group tagged phosphatidylethanolamine (*PE) as a lipoprotein reference marker. Fluorescent Bodipy cholesterol (*Chol) and *PE directly incorporated into whole plasma lipoproteins in proportion to lipoprotein cholesterol and phospholipid mass, respectively. *Chol, but not *PE, passively exchanged between isolated plasma lipoproteins. Fluorescent apoA-I (*apoA-I) specifically bound to high-density lipoprotein (HDL) and remodeled *PE- and *Chol-labeled synthetic lipoprotein-X multilamellar vesicles (MLV) into a pre-? HDL-like particle containing *PE, *Chol, and *apoA-I. Fluorescent MLV-derived *PE specifically incorporated into plasma HDL, whereas MLV-derived *Chol incorporation into plasma lipoproteins was similar to direct *Chol incorporation, consistent with apoA-I-mediated remodeling of fluorescent MLV to HDL with concomitant exchange of *Chol between lipoproteins. Based on these findings, we developed a model system to study lipid transfer by depositing fluorescent *PE and *Chol-labeled on calcium silicate hydrate crystals, forming dense lipid-coated donor particles that are readily separated from acceptor lipoprotein particles by low-speed centrifugation. Transfer of *PE from donor particles to mouse plasma lipoproteins was shown to be HDL-specific and apoA-I-dependent. Transfer of donor particle *PE and *Chol to HDL in whole human plasma was highly correlated. Taken together, these studies suggest that cell-free *PE efflux monitors apoA-I functionality.
Effects of cholesterol on thermal stability of discoidal high density lipoproteins.
Project description:Reverse cholesterol transport in plasma involves variations in HDL cholesterol concentration. To understand physicochemical and functional implications of such variations, we analyzed stability of reconstituted HDL containing human apolipoproteins (apoA-I, apoA-II, or apoC-I), phosphatidylcholines varying in chain length (12-18 carbons) and unsaturation (0 or 1), and 0-35 mol% cholesterol. Lipoprotein heat denaturation was monitored by circular dichroism for protein unfolding/dissociation and by light scattering for particle fusion. We found that cholesterol stabilizes relatively unstable complexes; for example, incorporation of 10-30 mol% cholesterol in apoC-I:dimyristoyl phosphatidylcholine complexes increased their kinetic stability by deltaDeltaG* congruent with 1 kcal/mol. In more stable complexes containing larger proteins and/or longer-chain lipids, incorporation of 10% cholesterol did not significantly alter the disk stability; however, 15% or more cholesterol destabilized the apoA-I-containing complexes and led to vesicle formation. Thus, cholesterol tends to stabilize less stable lipoproteins, apparently by enhancing favorable packing interactions, but in more stable lipoproteins, where such interactions are already highly optimized, the stabilizing effect of cholesterol decreases and, eventually, becomes destabilizing. These results help uncouple the functional roles of particle stability and chain fluidity and suggest that structural disorder in HDL surface, rather than chain fluidity, is an important physicochemical determinant of HDL function.
Effects of Disease-Causing Mutations on the Conformation of Human Apolipoprotein A-I in Model Lipoproteins.
Project description:Plasma high-density lipoproteins (HDLs) are protein-lipid nanoparticles that transport lipids and protect against atherosclerosis. Human apolipoprotein A-I (apoA-I) is the principal HDL protein whose mutations can cause either aberrant lipid metabolism or amyloid disease. Hydrogen-deuterium exchange (HDX) mass spectrometry (MS) was used to study the apoA-I conformation in model discoidal lipoproteins similar in size to large plasma HDL. We examined how point mutations associated with hereditary amyloidosis (F71Y and L170P) or atherosclerosis (L159R) influence the local apoA-I conformation in model lipoproteins. Unlike other apoA-I forms, the large particles showed minimal conformational heterogeneity, suggesting a fully extended protein conformation. Mutation-induced structural perturbations in lipid-bound protein were attenuated compared to the free protein and indicated close coupling between the two belt-forming apoA-I molecules. These perturbations propagated to distant lipoprotein sites, either increasing or decreasing their protection. This HDX MS study of large model HDL, compared with previous studies of smaller particles, ascertained that apoA-I's central region helps accommodate the protein conformation to lipoproteins of various sizes. This study also reveals that the effects of mutations on lipoprotein conformational dynamics are much weaker than those in a lipid-free protein. Interestingly, the mutation-induced perturbations propagate to distant sites nearly 10 nm away and alter their protection in ways that cannot be predicted from the lipoprotein structure and stability. We propose that long-range mutational effects are mediated by both protein and lipid and can influence lipoprotein functionality.
Triglyceride increase in the core of high-density lipoproteins augments apolipoprotein dissociation from the surface: Potential implications for treatment of apolipoprotein deposition diseases.
Project description:Lipids in the body are transported via lipoproteins that are nanoparticles comprised of lipids and amphipathic proteins termed apolipoproteins. This family of lipid surface-binding proteins is over-represented in human amyloid diseases. In particular, all major proteins of high-density lipoproteins (HDL), including apoA-I, apoA-II and serum amyloid A, can cause systemic amyloidoses in humans upon protein mutations, post-translational modifications or overproduction. Here, we begin to explore how the HDL lipid composition influences amyloid deposition by apoA-I and related proteins. First, we summarize the evidence that, in contrast to lipoproteins that are stabilized by kinetic barriers, free apolipoproteins are labile to misfolding and proteolysis. Next, we report original biochemical and biophysical studies showing that increase in triglyceride content in the core of plasma or reconstituted HDL destabilizes the lipoprotein assembly, making it more labile to various perturbations (oxidation, thermal and chemical denaturation and enzymatic hydrolysis), and promotes apoA-I release in a lipid-poor/free aggregation-prone form. Together, the results suggest that decreasing plasma levels of triglycerides will shift the dynamic equilibrium from the lipid-poor/free (labile) to the HDL-bound (protected) apolipoprotein state, thereby decreasing the generation of the protein precursor of amyloid. This prompts us to propose that triglyceride-lowering therapies may provide a promising strategy to alleviate amyloid diseases caused by the deposition of HDL proteins.
Morphology and structure of lipoproteins revealed by an optimized negative-staining protocol of electron microscopy.
Project description:Plasma lipoprotein levels are predictors of risk for coronary artery disease. Lipoprotein structure-function relationships provide important clues that help identify the role of lipoproteins in cardiovascular disease. The compositional and conformational heterogeneity of lipoproteins are major barriers to the identification of their structures, as discovered using traditional approaches. Although electron microscopy (EM) is an alternative approach, conventional negative staining (NS) produces rouleau artifacts. In a previous study of apolipoprotein (apo)E4-containing reconstituted HDL (rHDL) particles, we optimized the NS method in a way that eliminated rouleaux. Here we report that phosphotungstic acid at high buffer salt concentrations plays a key role in rouleau formation. We also validate our protocol for analyzing the major plasma lipoprotein classes HDL, LDL, IDL, and VLDL, as well as homogeneously prepared apoA-I-containing rHDL. High-contrast EM images revealed morphology and detailed structures of lipoproteins, especially apoA-I-containing rHDL, that are amenable to three-dimensional reconstruction by single-particle analysis and electron tomography.
Structures of discoidal high density lipoproteins: a combined computational-experimental approach.
Project description:Conversion of discoidal phospholipid (PL)-rich high density lipoprotein (HDL) to spheroidal cholesteryl ester-rich HDL is a central step in reverse cholesterol transport. A detailed understanding of this process and the atheroprotective role of apolipoprotein A-I (apoA-I) requires knowledge of the structure and dynamics of these various particles. This study, combining computation with experimentation, illuminates structural features of apoA-I allowing it to incorporate varying amounts of PL. Molecular dynamics simulated annealing of PL-rich HDL models containing unesterified cholesterol results in double belt structures with the same general saddle-shaped conformation of both our previous molecular dynamics simulations at 310 K and the x-ray structure of lipid-free apoA-I. Conversion from a discoidal to a saddle-shaped particle involves loss of helicity and formation of loops in opposing antiparallel parts of the double belt. During surface expansion caused by the temperature-jump step, the curved palmitoyloleoylphosphatidylcholine bilayer surfaces approach planarity. Relaxation back into saddle-shaped structures after cool down and equilibration further supports the saddle-shaped particle model. Our kinetic analyses of reconstituted particles demonstrate that PL-rich particles exist in discrete sizes corresponding to local energetic minima. Agreement of experimental and computational determinations of particle size/shape and apoA-I helicity provide additional support for the saddle-shaped particle model. Truncation experiments combined with simulations suggest that the N-terminal proline-rich domain of apoA-I influences the stability of PL-rich HDL particles. We propose that apoA-I incorporates increasing PL in the form of minimal surface bilayers through the incremental unwinding of an initially twisted saddle-shaped apoA-I double belt structure.
Compositional Features of HDL Particles Interact with Albuminuria to Modulate Cardiovascular Disease Risk.
Project description:Lipoproteins containing apolipoprotein B modify associations of elevated urinary albumin excretion (UAE) with cardiovascular disease (CVD). Additionally, it is known that elevated UAE alters high-density lipoprotein functionality. Accordingly, we examined whether HDL features might also modify UAE-associated CVD. Multivariable Cox proportional-hazards modeling was performed on participants of the PREVEND (Prevention of Renal and Vascular Endstage Disease) study at the baseline screening with standard lipid/lipoprotein analyses and, three-to-four years later (second screen), with nuclear magnetic resonance lipoprotein analyses focusing on HDL parameters including HDL particle (HDL-P) and apolipoprotein A-I concentrations. These were used with UAE and derived measures of HDL apoA-I content (apoA-I/HDL-C and apoA-I/HDL-P) in risk models adjusted for gender, age, apoB, diabetes, past CVD history, CRP and GFR. Interaction analysis was also performed. Baseline screening revealed significant associations inverse for HDL-C and apoA-I and direct for apoA-I/HDL-C. The second screening demonstrated associations inverse for HDL-P, large HDL-P, medium HDL-P, HDL size, and apoA-I/HDL-P. Significant interactions with UAE included apoA-I/HDL-C at the baseline screening, and apoA-I/HDL-P and medium HDL-P but not apoA-I/HDL-C at the second screening. We conclude that features of HDL particles including apoA-I/HDL-P, indicative of HDL apoA-I content, and medium HDL-P modify associations of elevated UAE with CVD risk.
Double superhelix model of high density lipoprotein.
Project description:High density lipoprotein (HDL), the carrier of so-called "good" cholesterol, serves as the major athero-protective lipoprotein and has emerged as a key therapeutic target for cardiovascular disease. We applied small angle neutron scattering (SANS) with contrast variation and selective isotopic deuteration to the study of nascent HDL to obtain the low resolution structure in solution of the overall time-averaged conformation of apolipoprotein AI (apoA-I) versus the lipid (acyl chain) core of the particle. Remarkably, apoA-I is observed to possess an open helical shape that wraps around a central ellipsoidal lipid phase. Using the low resolution SANS shapes of the protein and lipid core as scaffolding, an all-atom computational model for the protein and lipid components of nascent HDL was developed by integrating complementary structural data from hydrogen/deuterium exchange mass spectrometry and previously published constraints from multiple biophysical techniques. Both SANS data and the new computational model, the double superhelix model, suggest an unexpected structural arrangement of protein and lipids of nascent HDL, an anti-parallel double superhelix wrapped around an ellipsoidal lipid phase. The protein and lipid organization in nascent HDL envisages a potential generalized mechanism for lipoprotein biogenesis and remodeling, biological processes critical to sterol and lipid transport, organismal energy metabolism, and innate immunity.


Locura's menu (available from 5pm-9pm)takes a Latin American approach and showcases a variety of smaller style plates influenced by a blend of Mexican, Costa Rican and Peruvian cuisine. Menu items will feature a selection of cold and hot options including fried corn and chickpeas, oysters, ceviches, tacos and salads. There will also be a variety of house-made fermented hot sauces, rubs and salsas on offer. Something simple and tasty to accompany early evening drinks.
Award winning bartender, Tim Phillips, of Deadringer and Bulletin Place in Sydney, has joined forces with the Locura team to create an elevated cocktail list, complementing the food offering. The drinks menu is fun, fresh and flavoursome, with plenty of Tequila, Mezcal and Pisco based cocktails. The wine list features a compact selection of international organic, biodynamic and natural wines, with a smattering of South American wines. A changing selection of craft beers and ciders will be available on tap and in bottles and cans.


text:
Study: Infosec underestimates the importance of business communication
According to a recent study done by PricewaterhouseCoopers and (ISC)2, information security teams don't communicate well with other business units, which costs them valuable resources, as well as the general respect they need to get the job done.
Ron Condon
Published: 13 Oct 2010 5:00
Information security pros need to start recognizing the importance of business communication and speaking the language of business if they are to be taken seriously by senior management and the rest of the organisation, according to the results of a new study carried out jointly by (ISC)2 Inc., the industry training body and PricewaterhouseCoopers (PwC).
Security is about people, and if people are not interested or engaged by what you're saying, then you won't influence them
James Gay
CISOTravelex UK Ltd.
The two bodies asked senior CISOs working in UK organisations to identify how best to bridge the apparent communications gap that exists between information security, IT and senior management.
The full results of the study will be presented this week at RSA Conference Europe in London, offering some detailed advice to both management and security pros to help them work better together.
"Historically, business leaders and boards have tended to regard information security as a technology issue, but this is a complete misconception and needs to change," the report says. "The message is clear: Business leaders today ignore or underestimate information security risk at their peril."
PwC's research shows that many organisations' ability to secure their mission-critical corporate information is being undermined by a communications gap among the three key participants in any information security strategy: the business units, the IT function and the information security department. "Instead of working together toward common goals, these three stakeholders often fail to understand -- or even respect -- each other's roles and value to the organisation," it says.
While the business units often grudgingly accept the role that IT plays in the business, they often regard information security as a barrier to getting work done.
At the same time, IT feels underappreciated by the business and regards information security as the group that delays new system implementations by insisting on code inspections and penetration testing.
As for information security pros, they feel unappreciated and disliked by both the business and IT, and cannot understand why both of these units fail to understand the importance of their role. Yet when infosec pros try to explain the nature and scale of the threats facing the business and IT, the report says, they tend to come up against misunderstanding and incomprehension.
The study concedes that in some industries, such as financial services, regulatory and compliance pressures have helped information security sell the concept of security to the business and get security onto the business agenda. "But in most sectors this remains an uphill battle."
And yet, change could be on the way. In its new 2011 PwC Global State of Information Security Survey, PwC shows that chains of command are beginning to change in business, with more CISOs reporting directly to the board rather than through the CIO. The global study, based on information from 12,800 senior business people, found that 15% of CISOs now report to the chief operating officer (9% in 2007); 15% to the chief finance officer (11% in 2007); and 36% to the chief executive officer (32% in 2007).
"This appears to signal a growing executive recognition that security's strategic value should be more closely aligned with the business than with IT," the report concludes.
The communications gap
In their research with a group of UK CISOs, PwC and (ISC)2 uncovered a strong need to break down the communications gap among elements of the organisation. Stephanie Daman , head of information security risk at HSBC Plc., typified the general view: "Language is the biggest barrier," she is quoted as saying in the report. "In security [information security pros] don't speak business language, so what seems clear to us can sound like double Dutch to the people we are speaking to in the business. … Adding 'risk' to my job title has been very useful. The business understands 'risk'."
James Gay, CISO at Travelex UK Ltd., underlined the need for CISOs to have multiple skills: "As head of information security, you need to know about encryption, firewalls and so on. But if you go to the board and use that language, then you'll lose them immediately. Security is about people, and if people are not interested or engaged by what you're saying, then you won't influence them," Gay said.
The paper suggests the kinds of questions that could be used to help all three parties recognize and focus on their common goals. The programme, it says, should aim to articulate the importance of the organisation's critical corporate information -- ranging from customer databases to intellectual property -- and highlight the impact on the business should these assets be compromised. This means answering questions such as:
What information is most critical, and where and how is it held?
Why does it matter to everyone in the business that this information is kept secure?
Can the business place a value on this information in both financial and reputational terms, and if so, what is it worth?
What security risks does this information face, and what safeguards are in place to mitigate those risks?
What would be the financial, reputational and regulatory effects on the business if the information were compromised?
To bridge the divide between business and information security, the paper outlines five steps for the business leader to take, also outlining what he or she should ask of the information security leader:
Engage the whole board in the need for world-class information security standards, and get the organization's information security leader to outline threats and solutions, using straightforward business language and couching the message in terms of risk.
Discuss future strategic technology choices, identify forthcoming changes in areas such as device and application usage and involve the security leader in assessing the impact and implications if these shifts happen.
Rate the security of each business unit and, where risk is high, consider offering financial incentives to senior executives to help them focus on implementing top-level security standards.
Bring together people from information security, business and IT to brainstorm the threats and opportunities and debate solutions.
Over the long term, engage the security leader more deeply in the strategic agenda and future plans. Ensure that information security's key business role and relevance is understood and appreciated throughout the organisation.
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A medicinal herb is any one of the five herbs forageable by a herbalist.
There are five different types of medicinal herbs, with each having a unique effect applying to the player's health once consumed. The plantain, comfrey and wild garlic must first be crafted into a poultice using a mortar and pestle, whilst the others can be consumed raw.
Medicinal herbs can only be found by foraging. They will never be found unless the player has the herbalist trait or read The Herbalist magazine.
This page was last edited on 10 August 2018, at 12:26.


text:
Cherry Red Records Premier Challenge Cup
 16 Jan 2019 By Admin ccl
Quarter Final Draw on Monday 21 January
We now know five of the Premier Challenge Cup quarter-finalists following Tuesday's results and included amongst them are holders Knaphill, who are looking to retain the trophy they won last season. There was a bit of a shock brewing it seemed, when visitors Fleet Town from Division One took the lead but George Dorley scored in the second half to level matters up, followed by two late goals from Sheridan Campbell sent the Knappers through.
In other ties Bedfont & Feltham showed their credentials with the only goal of the match away to AFC Hayes who have been in good form lately. It was yet another goal from Michael Capon, way out in the goal scorers' list in Division One who did the trick.
Banstead though, also away to Division One opposition, enjoyed a solid 3-0 win at Sheerwater, whilst arguably the shock of the night came at Chertsey where 4th place Abbey Rangers won 2-1, both goals coming from Brad Thomas, the second one arriving in the closing minutes after Abbey had come under terrific pressure beforehand. An attendance of 172 witnessed this local derby.
In the other match, another very local derby between Spelthorne Sports and Hanworth Villa saw the latter secure the only goal of the game from Cyril Ocansey to go through.
Two of the other three remaining matches are taking place this evening whilst the tie between Epsom & Ewell and Godalming Town is scheduled for 12 February.
The draw for the Quarter-Finals will take place at the next Management Meeting on Monday 21 January and will be published the following day.
 SPECSAVERS SURREY SENIOR CUP Draw made for Quarter-Finals
Middx Premier Cup match OFF  BRIDGE STOPS PLAY
2019-03-13 Fleet Spurs v Sandhurst Town  15 Apr 2019
2019-03-30 Fleet Spurs v Bedfont & Feltham  2 Apr 2019
2019-03-23 Godalming Town v Fleet Spurs  25 Mar 2019
The Cherry Red Records Combined Counties Football League newsletter
The Cherry Red Records Combined Counties Football League


Art Gallery Cards: Art Gallery Cards Newsletter For the Week of August 10, 2015--Halloween! Christmas! Shaker Cards!
Art Gallery Cards Newsletter For the Week of August 10, 2015--Halloween! Christmas! Shaker Cards!
I hope this week finds you happy, healthy and enjoying many creative pursuits!
We had a fun and happy day yesterday creating 2 really terrific cards.
We are adding to our Christmas card collections with the pretty and simple card below. Just a quick stamp, punch and voila! I can see myself making 10 or 15 of theses for my Christmas card recipients. Our card base is Smoky Slate and while the Red Glimmer Paper added WOW, the simple Gold Glimmer Paper star added the pop!
We were able to use the Whisper White tree punchout on the inside of our card to make the inside pretty too!
Boo! Trick or Treat! Yes, while we're thinking of Christmas, we're also thinking of the younger set and Halloween fun! Retro stamps (both cards) provided a grand array of cute and spooky for our card! I love it when my students inspire me! Thank you, Dara, for the idea for crooked windows for our haunted house! Thank you, Sharon, for the idea for our "eyeballs" using our White Perfect Accents. (Can't wait to share another idea for a pinwheel design from Sharon. I'm thinking Christmas colors!) The orange dots are the accents colored with an orange Sharpie. Brilliant!! Our base is Tangerine Tango (always a favorite!).
We were done in record time and that left time for shopping, lunch out and relaxation for the AGOV stampers! You're awesome, gals! Can't wait for next week!! We'll be making a Christmas card and a fall card.
Yayyyyyy! We get to shop for school supplies too! (Don't you just love Office Depot and all of the various and sundry supplies!!) You can order at www.reenathan.stampinup.net or you can email your order to me at reenathan@bellsouth.net All "freebies" and perks aply!!
Art Gallery Stampers will meet at 10:30 am and at 1:30 pm (2 identical classes) on Monday, August 17 at the Art Gallery of Viera. Please RSVP by email by Saturday, August 15.
August 12 from 9:30-11:30 am. Come and join us for 3 great projects.
Yes, Holiday Catties Will Soon Be On Their Way!
If you don't have one, email me to get on my mailing list! You. will. love. this. brochure!!!!
I made some of my shaker cards this morning! They were so much fun!!
Overflow date is Saturday, 9/12, 1-3 pm at the Oasis (My home.) Email Ree to reserve your spot!
Friday, September 11, 1:30-3:30 pm, Art Gallery of Viera. Price is at cost at $29. Kit makes 18 fun shaker Christmas cards and includes all supplies. We'll make 6-8 during the workshop and you'll be able to then complete the kit on your own. RSVP to Ree by 9/1.
Come and make the cutest Halloween centerpiece ever. Too adorable! All supplies are provided in the at cost price of $25. Thursday, September 17, 2-4 pm at the Art Gallery of Viera. RSVP to Ree by 9/7.
Friday, October 16, 1:30-3:30 pm at the Art Gallery of Viera. Join us for a fun time creating a pretty briefcase, using a stamp case (wooden stamp sized), beautiful papers, punches and dies. We'll also create 4 coordinating note cards and envelopes to complete the gift, all for $15. RSVP to Ree by 10/7.
Snowflakes and Holly Berries Just 2 seats left! Overflow date is Saturday, November 7 at the Oasis.
Christmas Cards Workshop: Friday, October 30, 1:30-3:30 p at the Art Gallery of Viera. It's never to early to start creating your beautiful, handmade Christmas cards. Join us to make 6 cards (2 each of 3 different designs). All supplies are provided. Just bring your favorite adhesive. (I recommend snail tape runners.)Cost of the workshop is $20. RSVP to Ree by October 23.