text:
nature nanotechnology
A novel magnetic crystal–lipid nanostructure for magnetically guided in vivo gene delivery
Yoshihisa Namiki1,
Tamami Namiki2,
Hiroshi Yoshida3,
Yukiko Ishii1,2,
Akihito Tsubota1,
Shigeo Koido4,
Kouichi Nariai5,
Makoto Mitsunaga4,
Satoru Yanagisawa6,
Hideyuki Kashiwagi6,
Yasuo Mabashi1,
Yoko Yumoto1,
Sadayori Hoshina1,
Kiyotaka Fujise1,4 &
Norio Tada1,7
Nature Nanotechnology volume 4, pages 598–606 (2009)Cite this article
Cancer gene therapy requires a safe and effective gene delivery system. Polymer- and lipid-coated magnetic nanocrystals have been used to deliver silencing RNA, but synthesizing these magnetic vectors is difficult. Here, we show that a new nanoparticle formulation can be magnetically guided to deliver and silence genes in cells and tumours in mice. This formulation, termed LipoMag, consists of an oleic acid-coated magnetic nanocrystal core and a cationic lipid shell. When compared with the commercially available PolyMag formulation, LipoMag displayed more efficient gene silencing in 9 of 13 cell lines, and better anti-tumour effects when systemically administered to mice bearing gastric tumours. By delivering an optimized sequence of a silencing RNA that targets the epidermal growth factor receptor of tumour vessels, the intended therapeutic benefit was achieved with no evident adverse immune reaction or untoward side effects.
Controlled drug delivery vehicles for cancer treatment and their performance
Sudipta Senapati
, Arun Kumar Mahanta
… Pralay Maiti
Signal Transduction and Targeted Therapy Open Access 16 March 2018
A novel targeted angiogenesis technique using VEGF conjugated magnetic nanoparticles and in-vitro endothelial barrier crossing
Mark Christopher Arokiaraj
BMC Cardiovascular Disorders Open Access 28 July 2017
Magnetic forces enable controlled drug delivery by disrupting endothelial cell-cell junctions
Yongzhi Qiu
, Sheng Tong
… Gang Bao
Nature Communications Open Access 08 June 2017
Figure 1: The preparation and in vitro nucleic acid delivery efficiency of LipoMag.
Figure 2: LipoMag-mediated delivery of nucleic acid to tumour lesions under a magnetic field.
Figure 3: Biodistribution of siRNA delivered by LipoMag and PolyMag.
Figure 4: Screening EGFR-targeted siRNA and avoiding cytokine induction by chemical modification.
Figure 5: Anti-tumour effect of tumour vessel-targeted RNA interference delivered by LipoMag and PolyMag.
Figure 6: RACE-PCR analysis.
Kato, H. et al. (ed.) Cancer Statistics in Japan (Foundation for Promotion of Cancer Research, 2008).
Fire, A. et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391, 806–811 (1998).
Li, C. X. et al. Delivery of RNA interference. Cell Cycle 5, 2103–2109 (2006).
Toub, N., Malvy, C., Fattal, E. & Couvreur, P. Innovative nanotechnologies for the delivery of oligonucleotides and siRNA. Biomed. Pharmacother. 60, 607–620 (2006).
Scherer, F. et al. Magnetofection: enhancing and targeting gene delivery by magnetic force in vitro and in vivo. Gene. Ther. 9, 102–109 (2002).
Huth, S. et al. Insights into the mechanism of magnetofection using PEI-based magnetofectins for gene transfer. J. Gene Med. 6, 923–936 (2004).
Kamau, S. W. et al. Enhancement of the efficiency of non-viral gene delivery by application of pulsed magnetic field. Nucleic Acid Res. 34, e40 (2006).
Plank, C. et al. The magnetofection method: using magnetic force to enhance gene delivery. Biol. Chem. 384, 737–747 (2003).
Neuberger, T., Schopf, B., Hofmann, H., Hoffmann, M. & von Rechenberg, B. Superparamagnetic nanoparticles for biomedical applications: possibilities and limitations of a new drug delivery system. J. Magn. Magn. Mater. 293, 483–496 (2005).
Harris, L. A. et al. Magnetite nanoparticle dispersions stabilized with triblock copolymers. Chem. Mater. 15, 1367–1377 (2003).
Krotz, F. et al. Magnetofection: a highly efficient tool for antisense oligonucleotide delivery in vitro and in vivo. Mol. Ther. 7, 700–710 (2003).
Lawrie, A. et al. Ultrasound enhances reporter gene expression after transfection of vascular cells in vitro. Circulation 99, 2617–2620 (1999).
Berg, K. et al. Photochemical internalization: a novel technology for delivery of macromolecules into cytosol. Cancer Res. 59, 1180–1183 (1999).
Namiki, Y. et al. Enhanced photodynamic anti-tumor effect on gastric cancer by a novel photosensitive stealth liposome. Pharmacol. Res. 50, 65–76 (2004).
De Cuyper, M. & Joniau, M. Mechanistic aspects of the adsorption of phospholipids onto lauric acid stabilized magnetite nanocolloids. Langmuir 7, 647–652 (1991).
Chandler, D. Interfaces and the driving force of hydrophobic assembly. Nature 437, 640–647 (2005).
Kauzmann, W. Some forces in the interpretation of protein denaturation. Adv. Prot. Chem. 14, 1–63 (1959).
Rosenweig, R. E. Magnetic fluids. Int. Sci. Tech. 55, 48–56 (1966).
Reimers, G. W. & Khalafalla, S. E. Production of magnetic fluids by peptization techniques. U.S. patent 3,843,540 (1974).
Hirota, Y., Suzuki, H. & Tsuda, S. Magnetic fluid having an improved chemical stability by surface modifying treatment. Proceedings of the Japan Society of Magnetic Fluid Research Annual Conference 27–29 (Tohoku University, Sendai, Japan, 2003).
Namiki, Y. et al. Preclinical study of a 'tailor-made' combination of NK4-expressing gene therapy and gefitinib (ZD1839, IressaTM) for disseminated peritoneal scirrhous gastric cancer. Int. J. Cancer 118, 1545–1555 (2006).
Patel, P. C., Giljohann, D. A., Seferos, D. S. & Mirkin, C. A. Peptide antisense nanoparticles. Proc. Natl Acad. Sci. USA 105, 17222–17226 (2008).
Cho, S. W. et al. Delivery of small interfering RNA for inhibition of endothelial cell apoptosis by hypoxia and serum deprivation. Biochem. Biophys. Res. Commun. 376, 158–163 (2008).
Jangi, S. M. et al. Terfenadine-induced apoptosis in human melanoma cells is mediated through Ca2+ homeostasis modulation and tyrosine kinase activity, independently of H1 histamine receptors. Carcinogenesis 29, 500–509 (2008).
Folkman, J. & Shing, Y. Angiogenesis. J. Biol. Chem. 267, 10931–10934 (1992).
Amin, D. N., Hida, K., Bielenberg, D. R. & Klaqsbrun, M. Tumor endothelial cells express epidermal growth factor receptor (EGFR) but not ErbB3 and are responsive to EGF and to kinase inhibitors. Cancer Res. 66, 2173–2180 (2006).
Judge, A. D., Bola, G., Lee, A. C. & MacLachlan, I. Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo. Mol. Ther. 13, 494–505 (2006).
Robbins, M. et al. Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation. Hum. Gene Ther. 19, 991–999 (2008).
Elbashir, S. M., Martinez, J., Patkaniowska, A., Lendeckel, W. & Tuschl, T. Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate. EMBO J. 20, 6877–6888 (2001).
Soutschek J. et al. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature 432, 173–178 (2004).
Serikawa, T., Suzuki, N., Kikuchi, H., Tanaka, K. & Kitagawa, T. A new cationic liposome for efficient gene delivery with serum into cultured human cells: a quantitative analysis using two independent fluorescent probes. Biochim. Biophys. Acta 1467, 419–430 (2000).
Takahashi, T., Namiki, Y. & Ohno, T. Induction of the suicide HSVtk gene by activation of the Egr-1 promoter with radioisotopes. Hum. Gene Ther. 8, 827–833 (1997).
Namiki, Y., Takahashi, T. & Ohno, T. Gene transduction for disseminated intraperitoneal tumor using cationic liposomes containing non-histone chromatin proteins. Gene Ther. 5, 240–246 (1998).
Hida, K., Hida, Y. & Shindoh, M. Understanding tumor endothelial cell abnormalities to develop ideal anti-angiogenic therapies. Cancer Sci. 99, 459–466 (2008).
We dedicate this study to the late T. Terada for his fight against cancer, which came too early in his life. HSC39, HSC43 and HSC45 were kindly donated by K. Yanagihara. OCUM-2MD3 was kindly donated by M. Yashiro. This work was supported by an Industrial Technology Research Grant, Program 08C46049a (2008), from the New Energy and Industrial Technology Development Organization (NEDO) of Japan, the Futaba Electronics Memorial Foundation (2008), the Takeda Science Foundation (2007) and the Tsuchiya Foundation (2006).
Institute of Clinical Medicine and Research, The Jikei University School of Medicine, 163-1 Kashiwa-shita, Kashiwa, Chiba, 277-8567, Japan
Yoshihisa Namiki, Yukiko Ishii, Akihito Tsubota, Yasuo Mabashi, Yoko Yumoto, Sadayori Hoshina, Kiyotaka Fujise & Norio Tada
Department of Radiology, The Jikei University School of Medicine, 163-1 Kashiwa-shita, Kashiwa, Chiba, 277-8567, Japan
Tamami Namiki & Yukiko Ishii
Department of Laboratory Medicine, The Jikei University School of Medicine, 163-1 Kashiwa-shita, Kashiwa, Chiba, 277-8567, Japan
Hiroshi Yoshida
Division of Gastroenterology and Hepatology, The Jikei University School of Medicine, 163-1 Kashiwa-shita, Kashiwa, Chiba, 277-8567, Japan
Shigeo Koido, Makoto Mitsunaga & Kiyotaka Fujise
Laboratory Animal Facilities, The Jikei University School of Medicine, 163-1 Kashiwa-shita, Kashiwa, Chiba, 277-8567, Japan
Kouichi Nariai
Department of Surgery, The Jikei University School of Medicine, 163-1 Kashiwa-shita, Kashiwa, Chiba, 277-8567, Japan
Satoru Yanagisawa & Hideyuki Kashiwagi
Division of General Medicine, The Jikei University School of Medicine, 163-1 Kashiwa-shita, Kashiwa, Chiba, 277-8567, Japan
Norio Tada
Yoshihisa Namiki
Tamami Namiki
Yukiko Ishii
Akihito Tsubota
Shigeo Koido
Makoto Mitsunaga
Satoru Yanagisawa
Hideyuki Kashiwagi
Yasuo Mabashi
Yoko Yumoto
Sadayori Hoshina
Kiyotaka Fujise
Y.N. and T.N. conceived and designed the experiments. Y.N., H.Y., A.T., K.N., S.K, M.M., Y.M. and Y.Y. performed the experiments. Y.N., H.Y. and Y.I. co-wrote the paper. T.N. performed the statistical analysis. S.Y. and H.K. supplied the clinical specimens from gastric cancer patients. S.H., K.F. and N.T. supervised the project.
Correspondence to Yoshihisa Namiki.
Supplementary information (PDF 4827 kb)
Namiki, Y., Namiki, T., Yoshida, H. et al. A novel magnetic crystal–lipid nanostructure for magnetically guided in vivo gene delivery. Nature Nanotech 4, 598–606 (2009). https://doi.org/10.1038/nnano.2009.202
DOI: https://doi.org/10.1038/nnano.2009.202
Arun Kumar Mahanta
Pralay Maiti
Magnetic nanoparticles based cancer therapy: current status and applications
Huan Zhang
Xiao Li Liu
Hai Ming Fan
Science China Life Sciences (2018)
BMC Cardiovascular Disorders (2017)
Sheng Tong
Gang Bao
Synergistically enhanced selective intracellular uptake of anticancer drug carrier comprising folic acid-conjugated hydrogels containing magnetite nanoparticles
Haneul Kim
Ara Jo
Jinhwan Yoon
Silence the target
Christian Plank
Nature Nanotechnology News & Views 23 Aug 2009
Nature Nanotechnology (Nat. Nanotechnol.) ISSN 1748-3395 (online) ISSN 1748-3387 (print)
Find nanotechnology articles, nanomaterial data and patents all in one place. Visit Nano by Nature Research


Haskins Laboratories (President: Kenneth Pugh, PhD), located in New Haven, Connecticut, is a world-renowned research institute that focuses on the biological bases of speech, language and reading. The institute is affiliated with both the University of Connecticut and Yale University. The partnership with Haskins Laboratories primes the way to extend our efforts beyond the Bay Area.
The Dyslexia Foundation (TDF) is a non-profit dedicated to the identification and assistance of children with dyslexia. The program, established in 1989, aims to achieve higher levels of learning and promote better reading. A partnership with The Dyslexia Foundation places the UCSF Dyslexia Center in a position to maximize our success in translating research to outreach and practice.
The Education and Brain Sciences Research Lab (Director: Laurie Cutting, PhD) at Vanderbilt University is a top-notch facility dedicated to the investigation of the neural correlates of learning. Their primary focus is on the successes and failures of reading, including interventions and reading comprehension. The partnership with Vanderbilt emphasizes our strong collaborative relationships with other premiere laboratories and dedication to alleviating the burden of reading disability nationwide.
The UC Merced Alliance is a partnership of groups and individuals engaged in service and research related to the healthy development of children and their families in and around the unique contexts of the San Joaquin Valley and nearby rural mountain regions.
We are currently seeking school-wide partnerships. If you have any non-dyslexic elemenatry school children, please visit this page.


In a little more than a week, I will celebrate another trip around the globe sun.? (Thanks FuriousBall for the correction!)? In order to share the love, I make this one time offer.
I will answer your questions here next week. Feel free to ask anything you'd like. But remember the rules of questions: Only ask questions you want to know the answers to.
Leave questions as comments or shoot me an email at opengrove@gmail.com.
Not curious? That's cool. We'll still party.
UPDATE:?? I have solemnly sworn not to speak about certain people on this blog.? Even telling you who would break my promise. ? So if you have a people question, it's best to email.
So, I'm thinking about changing my God.
I think I'm going to change my God from Yahwey to Haashch????ti??.? Now before you just click away, let me explain.
Yahwey gave the tribe of Israel the most valuable piece of property in the Middle East.? Long after the OPEC nations runs out of oil, Israel will reside on the only access to the Mediterranean in the Middle East. (Pricey property, right?)? In return for this gift, the tribe of Israel has spent the last 3,000 years (King David united Israel in 1005 BC) fighting over this land.
The Navajo God, Haashch????ti??, gave the Dinetah the Navajo Nation.? No one in their right mind wanted that property.? So while most Native American tribes were shuffled off some remote uninhabitable location, the United States Government couldn't find a more uninhabitable place for the Navajo.? So the US Government told the Navajo to go home.
That's not to mention Uranium, Coal, the only road from Utah to Arizona and all the money that can be swindled earned in a casino.
Now before you send me nasty email, Israel is also a beautiful country.
3000 years of war or Uranium, Coal, road, casino?
Ok, I always talk about the importance of laughing at yourself. Right? Right?
So I'm a little behind.
In my wanderings around the web last week, I found that people seemed really sad. Some had recently lost loved ones. Other bloggers were bogged down under the day to day rejection of their dreams. Still others seemed just to have the mid-winter blahs. A lot of people are in transition, stressed out, anxious, frustrated and dealing with angry, frustrate, stressed out people.
And on Monday we say another "howdy" to Mercury in Retrograde.
I found this in Yoga Journal and thought it might help.
"For Los Angeles cardiologist Alejandro Junger, love is a great healer. Along with performing EKGs and prescribing exercise and diet plans, Junger teaches a simple visualization technique to his patients that focuses on love, which he believes can help mend a weak heart - and more.
"Start by closing your eyes. Take some deep breaths and picture in great detail someone you love - seeing them smile, hearing them laugh. Then imagine telling the object of your affection how mush you love them.
"Junger believes that depression, anxiety, and even heart disease can arive from having a 'closed' heart, or not fully experiencing your emotions. When you bring love into your consciousness, you release that emotional constriction and open your heart center, resulting in improved mood and an overall sense of well-being. The body responds to the sensation of love by secreting endorphins, which counteract stress and lower blood pressure. Junger adds that people report feelings of warmth and ease filling their chests while they do the exercise. 'It's a tool you can use outside the office for a more holistic approach to health,' he says.
I hope this little meditation helps brighten your corner of the world.


text:
A classe Júpiter foi um modelo de lanchas de fiscalização pequenas (LFP), ao serviço da Marinha Portuguesa, entre 1965 e 1975.

As lanchas foram construídas nos Estaleiros Navais do Mondego, na Figueira da Foz, sendo baptizadas com nomes de planetas.

A maioria das embarcações da classe foram atribuídas à Esquadrilha de Lanchas do Niassa, baseada em Metangula, Moçambique. Para isso, foram organizadas complexas operações de transporte, por caminho de ferro e por estrada, para as fazer percorrer as centenas de quilómetros que separavam os portos do Índico do lago Niassa. No Niassa, as lanchas participaram em missões de vigilância e de proteção das águas portuguesas do lago, contra as forças da Frelimo e da Tanzânia, bem como em missões de transporte e de apoio aos fuzileiros navais e missões de cooperação com o Exército, Força Aérea e forças do Malawi.

Em 1975, as lanchas foram cedidas à nova República Popular de Moçambique.

Unidades

Referências

Jupiter
Jupiter

redpajama_set_name: RedPajamaWikipedia


Cumbria Stone Walling provides a range of stonemasonry services specifically designed for the restoration and repair of older buildings. All of my stonework is crafted using traditional methods and designed to compliment local vernacular styles and the individual character of your property.
Modern stone saws and power tools make efficient work of shaping stone, but can result in a finish which appears lifeless when used in traditional buildings. At Cumbria Stone Walling, I believe that understanding the tools and techniques traditionally used in stonemasonry can significantly improve the appearance of new stone.
Conservation area and listed building rules often set stringent restrictions on construction standards and sourcing and working new stone sympathetically can significantly help with the approvals process.


I'm just back home from an inspirational couple of days at CukenFest, time for a quick summary while things are still fresh in my head.
Time to catch up on my blogging plans for this project before moving on to the next one. The next step in the process was to create a model of my Christmas tree in xLights so that xLights knows how it looks, then create some simple sequences to be run when the status of builds in Jenkins changes.
Last weekend I attended Oslo Elm Day. Oslo Elm Day is an two track conference of talks regarding the Elm language with 174 attendees. Personally I'm quite excited about the promise of writing applications that can't crash at runtime and want to learn more.
While I'm reasonably comfortable running Linux on the desktop these days, connecting to a projector has always been a challenge, until yesterday when I finally found the right link on the internet to explain what I needed.
I'm currently on my second office where the preferred computer setup for developers is to run Linux in a VM on a beefy laptop. From Windows the DirectAccess VPN works out of the box, but giving Linux in a VM the same access has proved to be non-trivial. What follows is a step by step configuration that worked for me.
Meet my Christmas nerd project from last year.
Since early summer last year I've been working on a small hobby project in Rust. I recently reached a level of functionality where it might be useful to someone so I wanted to write a few words about the project.
For reasons that I touch upon at the end of the post I've been starting to look into Rust for "back-end" projects that I write in my spare time, and I want to brain dump my initial thoughts when trying something new or investigating a new crate. First up is Serde.


text:
Weird Tales of the City: An Anarchist History of the San Francisco Bay Area Forteans, 1920-1959 (xv)
It is common to look upon Forteans as atavists—people seeking refuge from the harshness of modern life by indulging a fascination for an imagined past. Recent research has called into question this schema, suggesting that modernity and enchantment grow together. This view is consistent with Scott's argument about those who did not want to be ruled: often dismissed as primitive holdovers, they, instead, co-evolved with the paddy state, adapting their lifestyles to the growth of the state. They traded, too. Citizens of the state had products that made life more convenient for the hill tribes—proving again that their lifestyles were patchworks of the modern and the old—and the hill tribes had access to goods citizens did not: fruits and other foods that grew only in the forest, for example, artisanal products. Thus, even as the hill tribes tried to remain free from the coercive force of the state, they still engaged with it. The same was true of the Forteans although, of course, not everyone was interested in such trade.
The flow of material and ideas from science to the Forteans is the easiest to document. Fort, clearly, was not interested in retreating to a Romantic past. He read scientific journals, grappled with scientific ideas—he was, perhaps, the first popular writer on the new Quantum Mechanics, for example. He took these scientific facts and re-interpreted them according to the logic of his monistic system. Bern Porter, too, was an example of this trade: brought to his art a familiarity with modern science and its techniques, that he then attempted to put to other uses. Fortean science fiction writers such as Garen Drussai and Anthony Boucher were consumers of science, too, keeping up with developing ideas so that they could incorporate them into their stories. Boucher, for instance, wrote a story that turned on forensic science—in particular, that two people could have the same fingerprint. (Thayer wrote documented examples of this in Doubt; he was no friend of forensics.) E. Hoffman Price and Philip Lamantia were both astrologists. Astrology was an outdated science, no doubt, but its continued practice required an understanding of astronomy, and thus their work necessitated familiarity with science.
What did Forteans provide to science in turn? Some were uninterested in the trade. Henry Miller, for example, also developed an interest in astrology, but he thought of it as only another language in which to speak—and not a way of studying the universe or understanding its mechanics. The same was true of his fascination with Madame Blavatsky's Theosophy: he came to admit she had probably invented her gurus, but what counted were not the facts: what counted was the poetry of her work. He had little interest in modern science—the Cosmodemonic Telegraph Company section of The Tropic of Capricorn is a stinging rebuke of modern organizations and their scientific rules—and saw little reason to contribute to science. "The gulf between knowledge and truth is infinite. Parents talk a lot about truth but seldom bother to deal in it. It's much simpler to dispense ready-made knowledge. More expedient too, for truth demands patience, endless, endless patience." Miller was a purveyor of truth, he thought. Other Forteans, such as Robert Barbour Johnson, similarly seemed to have little interest in science, either in learning from it or contributing to it, beyond seeking out examples of events that violated scientific expectations, such as the stones that fell on Irene Fellows's home.
But there were ways in which the Forteans passed ideas into science. Most obvious in this regard is George F. Haas, who did basic taxonomic work on the flower genus Penstemon in the late 1930s and early 1940s, as well as research on redwoods when he was a ranger at Big Trees State Park. Forteanism itself did not seem to drive Haas's interest in these subjects, but his involvement with both the Fortean Society and the American Penstemon Society show, at the very least, that Forteanism did not force one to reject all scientific knowledge. Similarly, Kenneth Rexroth worked in an asylum while he was a conscientious objector and developed some of his own ideas about therapy; George Leite was interested in criminology, as was, of course, Maynard Shipley. More speculatively, Forteans may have contributed to science in a less direct way: through their writings. Fantastic fiction is a well known influence on the scientific imagination—notably so during the 1920s, when scientists showed little interest in rocketry but science fiction fans and amateurs kept the dream of a rocket to the moon alive. It may be that Lamantia's surrealist poetry or Boucher's fantasies fire the imagination of later scientists. One of Fort's messages was that explanations of the world should not be taken at face value, but treated skeptically, tested, and probed: which is the exact job of new generations of scientists.

redpajama_set_name: RedPajamaCommonCrawl


People love getting really creative, one-of-a-kind books for Christmas. Books that elicit a "where did you find this?" response. As the leading indie- and self-publishing platform, Blurb has an entire online bookstore full of unique books by an incredible array of undiscovered, self-published authors, artists, and photographers. And while these books probably aren't in your recipient's bookshelf, many of them should be. So, if you're thinking of giving unique gifts this year, check out the Blurb bookstore.
This charming collection of original, vintage photos shows us that as long as there have been cameras, we've wanted to photograph our canine best friends. As a special bonus, there's a glossary of the early photographic methods used in the original images.
Whether you decide to buy one of the gift books from the Blurb bookstore, or create your own, be sure to head on over to Blurb now to get some ideas AND start tackling that long gift list! If you get inspired and decide to make your own photo books to give as gifts, you can take advantage of the FREE design tools and templates plus you'll save 30% on Blurb's Print Books with Blurb Promo Code: SAVE30 when you order by 11/30!
Here's a super great idea of what to do with all those cute pet and family photos you've taken this year…make a FREE photo book! It's perfect for your coffee table or to give as a gift and they are easy and fun to make DIY Pet Project!
Just order by September 11, 2013 (11:59 P.M. PT) and snag one free 20-page 8×8 hard photo cover photo book. Offer cannot be redeemed more than once per account and/or billing address. Taxes, shipping, and handling will apply. Make sure to use Shutterfly promo code SUMMERBOOK when you order.
Shutterfly has all kinds of design templates and themes so all you have to do is choose the one you like and drop your own photos and text in where you want it. I made one for Daisy's daddy last year for Christmas and it turned out really CUTE!
You can also use the free book offer to create a cookbook, baby book, vacation book, or just about any else you can think of. It's a great chance to put some of those favorite photos to use instead of leaving them trapped in your phone or digital camera! Go HERE to get started and remember to order by 9/11 and use Shutterfly promo code SUMMERBOOK at checkout!
Blurb Flash Sale: 25% OFF Photo Books Thru 2/25 Only!
Time seems to pass so quickly, and its so important to have something tangible to reflect on good times, hard work paying off, or simply being creative. The fur kids and human ones grow up so quickly…blink and you miss it! I love the idea of making Blurb books for just about every occasion and milestone, whether it be a wedding book, a birthday album, a secret family cookbook, all of your family trip pictures, even your Instagram account can be converted into a Blurb book! Of course, you could always make a book starring your dog, cat or other critter! A nice surprise as a gift or to treat yourself.
I have been meaning to make a new book for a while and as if Blurb read my mind, they are offering 25% off purchases from 2/22-2/25. Head over to Blurb now and tap into your creative side! To get your 25% off just make sure to use Blurb Promo Code FLASH25OFF when you order.
Facebook books that include photos, comments, and captions.
Planners with beautifully designed templates and your favorite photos.
Notebooks that are filled with photos, can be lined or unlined, and full of plenty of white space for you to add notes, stories or sketches.
Plus you can turn your printed book or magazine into an ebook! This is a great way to share your creation with others.
Daisy's Cute New Photo Book + Make Your Own with 40% OFF from Shutterfly!
One of my favorite gifts this year is actually one that I made myself. It's a photo book from Shutterfly.com made with some of my favorite photos of Daisy and her Papa! It was super easy to make and I wish I'd done it sooner since now I see what great keepsakes they are. You just choose the style, theme and layout you like and then either let it automatically fill in the pages, or do them one by one yourself.
I kept mine simple, but you can also add captions or text to tell a story, or even upload recipes and photos of your favorite family dishes and create a cookbook! A photo book would also make a great wedding present or baby book! You can use photos from Facebook too, and I really took advantage of that.
If you want to make your own photo book, now it a great time since Shutterfly is offering up to 40% Off! Just click here to get started making yours. You can save your project as you go and come back to it later so it's super-easy to play around with and see how you like it before ordering. Mine came out exactly the way I previewed it and I love it!
25% OFF Blurb Photo Books Made with Your Facebook or Instagram Photos!
Today through Monday, 12/3 create the perfect personalized gift and get 25% Off with Blurb when you use promo code HOLIDAYTHANKS. Blurb books are a great way to make thoughtful gifts for friends and family.
Also, don't forget, with Blurb you can now create a photo book in just 1 night by uploading your Instagram and Facebook images. Do something special with all your favorite pet or family photos! To receive your Blurb Book by Christmas, using ground shipping, the deadline is 12/10! Don't miss out on these great savings and create your Blurb book today!


Jacksonville Beach hosts a wide variety of festivals and events year round. It's a perfect spot for a pre/post convention stay!
Show off Jacksonville to your attendees with images and footage of Downtown and the beaches, our golf courses, parks, nightlife, shopping, waterways, outdoor activities, venues, sports, family attractions, and so much more!
Visit our online media gallery to find the perfect image or video for your needs, CLICK HERE and REGISTER to create a profile, wait for approval, then gain access to our online media gallery. Make sure you specify you are a CONVENTION GROUP.
If you have further questions, please reach out to Courtney Gumbinger.
NOTES: All images and videos are to be credited to Visit Jacksonville or the photographer (if there is one noted).


The admission to B.Tech (four year programme) and MCA (three year programme), shall be done by Haryana State Technical Education Society (HSTES) through Online Off Campus Counseling for academic session 2019-20. Admission to any institution will be governed by rules stated in Information Brochure of HSCS.
Admission for the 25 % seats will be done by the Institute through the conseling strictly on the basis of JEE-MAIN-19, OLET(LEET)-19, rank as per the schedule and procedure given below.
1. Submit the completed application form at the campus or office in Delhi (Adarsh Nagar and Shalimar Bagh). Application form can be obtained from the campus or admission office in Delhi. It can also be downloaded from the Institute's website by clicking the link below.
2. Admission will be done based on the Merit list displayed at the Institute.
3. Candidates are required to report for the counseling with all the original documents (for verification), 3 set of photocopies of all the documents (as mentioned in the brochure of HSTES) and 5 passport size colour photographs.
SBIT Information Brochure and Application Forms (for 25 % Management Seats ) are available from the Institute and from our Admission Office in Delhi: AG-16, Shalimar Bagh, Ring Road, Delhi � 110088 OR 236, Sarai Pipal Thala, Near Adarsh Nagar Metro Station, Opp Metro Pillar No 95, Adarsh Nagar, Delhi - 110033.


text:
Our Members In Action
VVA Member Benefits
Program Spotlight
Agent Orange & Other Toxic Exposures
Education | JROTC | Eagle Scout
Minority Affairs
PTSD & Substance Abuse
Veterans Health Care
Veterans Incarcerated and in the Justice System
Veterans Against Drugs
VVA Testimony
The VVA Veteran
Arts of War
Books in Review II
VVA Brochures
Inside VVA Chapters
Web Weekly
Chaplains Corner
Donate Join/Renew
Jack McManus to Serve as National President of Vietnam Veterans of America
Home » News » Press Releases
(Washington, D.C.) –Jack McManus was elected to serve as National President of Vietnam Veterans of America on November 6 at the organization's 20th National Convention in Greensboro, North Carolina. He was first elected VVA national…
VVA Applauds Legislation to Expand Vet Center Access to Underserved Veterans; Vet Centers Save Lives
(Washington, D.C.) – "Vietnam Veterans of America applauds Rep. Mikie Sherrill (NJ-11) and the bipartisan coalition of House Members for introducing the Vet CENTERS for Mental Health Act, H.R.5543, which calls for the expansion of…
Message from John Rowan on VA Healthcare After Receiving Pacemaker at Manhattan VAMC
(Washington, D.C.) – I am grateful to the staff of the Manhattan VA Medical Center as well as the medical team from New York University Medical School for the excellent care I received last week.…
VVA's Rick Weidman Honored as VVA Executive Director Emeritus
(Washington, D.C.) – "Richard F. "Rick" Weidman has led VVA's advocacy since his return to the National headquarters in 1998, fighting for change and ensuring our veterans receive the care and respect of a grateful…
VVA Applauds Swift Action of VA Secretary in Adding Bladder Cancer, Hypothyroidism, and Parkinsonism to list Agent Orange-recognized Diseases
(Washington, D.C.) --"VVA applauds VA Secretary Denis McDonough for his decision to immediately implement provisions of the William M. Thornberry National Defense Authorization Act for Fiscal Year 2021 (Public Law 116-283) by adding bladder cancer,…
VVA Applauds Major Policy Reversal by Joint Chiefs on Military Sexual Trauma
(Washington, D.C.) --"Vietnam Veterans of America applauds the recent decision of Joint Chiefs Chair Gen. Mark Milley to drop his opposition to policy changes on how the military handles sexual assault and his current openness…
POW/MIA Flag to Fly Over White House Again
"As of today, April 9, the POW/MIA flag will, once again, fly over the White House," said VVA National President John Rowan. "We are grateful to President Joe Biden for restoring the POW/MIA flag to…
VVA Applauds House Passage of VA VACCINE Act
(Washington, D.C.) -- "We applaud Chairman Mark Takano (D-Calif.) and Ranking Member Mike Boss (R-Ill) for the swift passage of H.R. 1276, The Department of Veterans Affairs Veterans' and Caregivers' COVID-19 Immunizations Now Expanded Act…
VVA President Rowan Presents VVA's Legislative Priorities before Congress; Calls for Recognition of Toxic Wounds
(Washington, D.C.) – "From Vietnam to the present-day, members of the U.S. military have been exposed to toxic elements, at home and abroad, that have killed more people than our enemies," said John Rowan, National…
VAOIG Faults VA Delivery of Services to Children of Vietnam Vets
(Washington, D.C.)--"The recent findings of the VA Office of Inspector General echo what we have long known. Most Vietnam veterans are unaware of the benefits available for children with certain birth defects due to their…
Receive the Latest VVA News
Stay informed about the latest veteran news
Arts of War(871)▾
Archives(14)
Art Exhibits(41)
Artistic Queries(108)
Arts on the Web(60)
Book News(135)
Book Talk(18)
Comic Books(7)
Conferences(16)
Dance(5)
Documentaries(115)
Drama(42)
Essays(31)
Feature Films(77)
History(111)
Honors and Prizes(14)
In the Classroom(24)
Journalism(34)
Journals(10)
Magazines(21)
Memorials(32)
Museums(27)
Musicals(10)
Obituaries(60)
On DVD(8)
On Line(17)
On Stage(17)
On TV(35)
Opera(1)
Plays(35)
Poetry(52)
Sculpture(8)
TV Series(10)
Benefits Updates(19)
Books in Review(694)▾
Anthology(3)
Antiwar Movement(9)
Audiobook(1)
Australian Vietnam veterans(1)
Biography(27)
Childrens(3)
Compliation(12)
Detective Novel(7)
Diplomatic History(3)
Electronic Book(94)
Fantasy(2)
Fiction(225)
Fiction War short stories(1)
Graphic Novel(1)
Guidebook(5)
Iraq War(1)
Memoir(55)
Military History(21)
Mystery(9)
Nonfiction(378)
Novel(78)
Oral History(15)
Paperback(428)
Papterback(1)
Play(2)
Reference(11)
Self Help(9)
Short Stories(19)
The Wall(1)
Thriller(25)
Vietnam Veterans Memorial(1)
Vietnam War(35)
Vietnam War biography(2)
Vietnam War fiction(4)
Vietnam War History(35)
Vietnam War memoir(7)
Vietnam War novel(7)
Vietnam War poetry(1)
Vietnam War post-traumatic stress disorder(1)
Vietnam War themed novel(10)
World War II novel(1)
Committee Reports(2)▾
Econominc Opportunities(2)
In Service Newsletter(13)
Inside VVA Chapters(654)
Membership Affairs(1)
Press Releases(189)
Programs(372)▾
Agent Orange(73)▾
Faces of Agent Orange(32)
Government Affairs(35)
Homeless Veterans(36)
Minority Affairs(20)
POW/MIA(68)
PTSD & Substance Abuse(45)
Veterans Against Drugs(9)
Veterans Health Care(19)
Veterans Incarcerated and in the Justice System(33)
Women Veterans(29)▾
Public Affairs(2)
The VVA Veteran(58)
VA Voluntary Service(3)
Vietnam veterans(32)
VVA Testimony(133)
Web Weekly(348)
Facebook Widget Plus
View Monthly Posts
View Monthly Posts Select Month January 2022 December 2021 November 2021 October 2021 September 2021 August 2021 July 2021 June 2021 May 2021 April 2021 March 2021 February 2021 January 2021 December 2020 November 2020 October 2020 September 2020 August 2020 July 2020 June 2020 May 2020 April 2020 March 2020 February 2020 January 2020 December 2019 November 2019 October 2019 September 2019 August 2019 July 2019 June 2019 May 2019 April 2019 March 2019 February 2019 January 2019 December 2018 November 2018 October 2018 September 2018 August 2018 July 2018 June 2018 May 2018 April 2018 March 2018 February 2018 January 2018 December 2017 November 2017 October 2017 September 2017 August 2017 July 2017 June 2017 May 2017 April 2017 March 2017 February 2017 January 2017 December 2016 November 2016 October 2016 September 2016 August 2016 July 2016 June 2016 May 2016 April 2016 March 2016 February 2016 January 2016 December 2015 November 2015 October 2015 September 2015 August 2015 July 2015 June 2015 May 2015 April 2015 March 2015 February 2015 January 2015 December 2014 November 2014 October 2014 September 2014 August 2014 July 2014 June 2014 May 2014 April 2014 March 2014 February 2014 January 2014 December 2013 November 2013 October 2013 September 2013 August 2013 July 2013 June 2013 May 2013 April 2013 March 2013 February 2013 January 2013 December 2012 November 2012 October 2012 September 2012 August 2012 July 2012 June 2012 May 2012 April 2012 March 2012 February 2012 January 2012 December 2011 November 2011 October 2011 September 2011 August 2011 July 2011 June 2011 May 2011 April 2011 March 2011 February 2011 January 2011 December 2010 November 2010 October 2010 September 2010 August 2010 July 2010 June 2010 May 2010 April 2010 March 2010 February 2010 January 2010 December 2009 November 2009 October 2009 September 2009 August 2009 July 2009 June 2009 May 2009 April 2009 March 2009 February 2009 January 2009 December 2008 November 2008 October 2008 September 2008 August 2008 July 2008 June 2008 May 2008 April 2008 March 2008 February 2008 January 2008 December 2007 October 2007 September 2007 July 2007 June 2007 April 2007 March 2007 February 2007 September 2006 August 2006 July 2006 June 2006 May 2006 March 2006 February 2006
Financial Readiness
"HELPING VETERANS, COMMUNITIES,
AND THOSE SERVING IN HARM'S WAY."
© 2022 Vietnam Veterans of America | All Rights Reserved
8719 Colesville Road, Suite 100, Silver Spring, MD 20910 | 301-585-4000
Media Kit |Privacy Policy | Credits | Veteran Collectibles | Resources


text:
Village dog DNA reveals genetic changes caused by domestication
Dogs were domesticated from wolves tens of thousands of year ago - though what exactly it is, at the genetic level, that distinguishes dogs from wolves, is unclear. Amanda Pendleton and Jeffrey Kidd, authors of a new study in BMC Biology, explain how they utilised new genomics technology - and village dogs - to address this question.
Dr. Amanda Pendleton & Dr. Jeffrey Kidd 28 Jun 2018
Two village dogs in Marrakech, Morocco.
"Dogs" (CC BY 2.0) by L.Wi.
The dog has been man's best friend for thousands of years, forming a relationship that pre-dates the establishment of agriculture. Domesticated animals, including dogs, share a distinctive collection of traits that distinguish them from their wild ancestors.
Changes in fur color and texture, the shape of ears, tail length and its curvature, eye color, and alterations in facial structure are some traits distinguishing dogs from wolves. Yet, the trait that most importantly differs is behavior. Thousands of years ago, dogs were tamed and domesticated from wolves, which over time yielded animals that were more and more friendly with humans, transforming the once wild creatures into the domestic dogs of today.
With the advent of modern genomics technology, a number of approaches have been used to search for the precise genetic changes that turned wolves into dogs.
The appearance of the gray wolf is very different from the look of modern dogs.
"Posing wolf" (CC BY 2.0) by Tambako the Jaguar.
Village dogs are essential genetic resources that help us understand dog evolution
We recently participated in a study that that used DNA from ancient dogs that lived among humans to address outstanding questions related to the timing of dog domestication. Ancient DNA technology is a genetic time machine, allowing researchers to directly see genetic variants that existed in the past.
When we assessed the genetic makeup of three European dogs from the Neolithic (five and seven thousand years old), we found something surprising: although genetics indicated that the three samples were clearly dogs, they carried the wild wolf sequence at many parts of the genome that were previously thought to be associated with domestication.
To explain this conundrum, in our new publication in BMC Biology, we turned to village dogs, which represent the vast majority of dogs on earth. These dogs are semi-feral, roam along our streets and cities, survive mostly off human trash, but most importantly, they are domesticated.
Village dogs, such as these lounging in a market in Chile, are common sights on busy city streets.
"Stray Dogs in Valparaiso, Chile" (CC BY 2.0) by Tim Adams.
In fact, these dogs are descended from the same ancestors as our favorite breed dogs today, and have been likely living with or near humans since the time of domestication, which occurred as long as ~40,000 years ago. Free-ranging village dogs serve as rich genetic resources, giving scientists a glimpse at the full range of genetic diversity and what it really means to be a dog.
Since the domestication of wolves thousands of years ago, dogs have slowly lost genetic diversity, but village dogs maintain much more.
By Amanda Pendleton.
Many dog-specific traits are determined by the neural crest
Much of what makes dogs look and behave the way they do is determined during their early development as an embryo. By the time dog puppies are born, their appearance and behaviors are already different than wolf puppies.
A village dog mother nurses her diverse-looking pups on a streets in Cairo, Egypt.
"DSC_0227" (CC BY 2.0) by RachidH.
These changes reflect the outcomes of complex and intricate processes during embryonic development and involve the movement and coordination of many cells that serve unique purposes. A few years ago, a group of researchers noticed that the diverse phenotypes of domesticated animals can be explained by differences in neural crest cells, which are stem cells that travel from their starting location, in what will become the spinal cord, along defined routes to their final destinations.
A village dog in Fiji poses for a photo.
Photo taken by Adam Boyko.
Neural crest cells play a major role in defining the forms and functions of multiple tissues in all animals with backbones including most of the skull, face, cartilaginous tissues (such as dogs' infamously charming floppy ears), and even pigmentation of the skin and fur. In addition to changing the outward appearance, these cells ultimately contribute to the development of the brain, nervous system, and adrenal systems, all of which can influence behavior.
Changes in the number or activity of neural crest cells in any of these final body locations can subsequently alter the size, shape, or level of expression of the corresponding trait.
What can the genomes of dogs and wolves tell us about domestication?
Free-ranging village dogs serve as rich genetic resources, giving scientists a glimpse at the full range of genetic diversity and what it really means to be a dog
By comparing the genetic diversity of village dogs and wolves we identified 246 regions of the genome which may have been altered during domestication. By using village dogs, which have not had a recent loss of diversity due to human directed inbreeding, we were able to find old events shared among living dogs and the ancient samples from the Neolithic, suggesting that we identified changes associated with the domestication process.
Interestingly, these changes were found near genes that perform critical functions in the developing dog, including many genes that are associated with the neural crest, nervous system function, and circadian rhythms. These findings offer clues to the genetic changes associated with domestication, and support the hypothesized role of alterations in neural crest cell function in this process.
Michelle White and Ryan Boyko collect DNA from a village dog in French Polynesia.
Photo by Adam Boyko
The precise details surrounding the process of domestication remain a mystery, but researchers can link archeological evidence with the patterns observed in genomes to help evaluate possible theories. One scenario suggests that in ancient times wolves lived near early human settlements, as they were attracted by trash or remains of hunted animals. Over time, some wolves may have become less fearful of humans, as these may have had more success in obtaining food.
These findings offer clues to the genetic changes associated with domestication, and support the hypothesized role of alterations in neural crest cell function in this process
During this gradual process, referred to as self-domestication, researchers hypothesize that genes involved in the neural crest pathway were slowly changing, leading to a wide range of different appearances relative to wild wolves and leaving signatures in the dog genome that we can detect today. At some point, humans began their active involvement in domesticating these "less wild" wolves, who already likely had a head start on the process, and other physical traits may have continued to accompany the behavioral changes.
Debate remains about when humans became directly involved in this process, but linked morphological and behavior changes can rapidly occur, as was found in the selective breeding of silver foxes.
Genes that are directly or indirectly linked to phenotypes that distinguish dogs from wolves. Our study identifies these genes as candidates for further study. Image inspired by Wilkins et al. 2014 Genetics.
Wikimedia commons.
Unraveling the mysteries of when wolves became dogs, how and why this happened, and how the domestication process affected modern dogs will not only help us understand the history of our furry companions, but also identify genes that may be pivotal to dog development and behavior. As more ancient dog and wolf samples are discovered and analyzed, we may soon be able to answer the many remaining questions regarding how dogs came to be.
Liked the blog? Now read the research:
Comparison of village dog and wolf genomes highlights the role of the neural crest in dog domestication
OPEN ACCESS ALTMETRIC
BMC Biologydogsdomesticationgenomicswolves
Folic acid supplements and gut bacteria
Assessing cognition in patients with early Alzheimer's disease – an experts views on the new FDA guidance
Lee Bergen 29th June 2018 01:11
I am confused: just looking at the pictures (you show) of vilage dogs it seems as if domestication occured at about the same time to the same degree on all continents sans Antarctica. Are you suggesting there were wolfes on Pacific islands? It seems strange that at this time they (the dogs) look remarkably alike. Even people have changed substantially more than dogs, in spite of many more generation of dogs than humans. OK, so I am missing the basics you would perhaps expect of your non-professional readers. Sorry, I am a physicist…
Dr. Amanda Pendleton & Dr. Jeffrey Kidd
Growing up in Florida with many family dogs, Amanda fell in love with the study of nature. After earning her Ph.D. in Plant Molecular and Cellular Biology at the University of Florida, she began a post-doc at the University of Michigan studying canine evolution in the lab of Dr. Jeffrey Kidd. Her research focuses on the evolutionary history of dogs and wolves, as well as genome variation across canine populations.
Dr. Kidd received his Ph.D. in Genome Sciences from the University of Washington where he studied the impact of genomic structural and copy-number variation. As a postdoctoral scholar at Stanford, he used population genetics models to understand the history of human populations and became fascinated with the evolution of modern dogs. Since 2012, Dr. Kidd has been at the University of Michigan where his lab studies the causes and consequences of genome variation as it relates to evolution and human disease.
Latest posts by Dr. Amanda Pendleton & Dr. Jeffrey Kidd (see all)
Village dog DNA reveals genetic changes caused by domestication - 28th June 2018


Free Download Software Proshow Gold 5.0.3222 Full Patch - Welcome to the blog free download software and PC games. This is my next post on the Free download Games PC and Software Blog. previously, i has been share Free Download Games PC : Plants vs Zombie 2 and Free Download Smadav Antivirus 9.6.1 2014 Full Serial, on this post, I 'll share one PC Software. the name of software is Free Download Software Proshow Gold 5.0.3222 Full Patch.
Are You like to design video or images ? if you include people who likes to design photos and video, then the software ProShow Gold can be compulsory that you must have. ProShow Gold is PC software that enables you to create videos using slideshow photo collated in such a way, so as to form a nice video to watch. ProShow Gold can turn your photos collection into an interesting video. equipped with music features, make your video more interesting to watch.
ProShow Gold is a software produced by Photodex. ProShow Gold has been released several times , until now the latest version of this software is ProShow Gold 5.0.3222. of course the latest version of the ProShow Gold has many newer features when compared with the previous feature feature . ProShow Gold 5.0.3222 is equipped with hundreds of transition effects, slide effects hundreds of videos that can make you become very attractive .
Click on Download Link Button, And Please wait about 5 Second.
Click Skip Add On top right your browser.
Your File Ready To Download.
Install ProShow Gold As usual to complete.
After the software is installed, do not always on the run, open Patch.rar extract it to the directory where you installed Prshow Gold.
Then open the patch and click Patch. now software you already Prosow Gold Full Version.
Ok, I think enough for article Free Download Software Proshow Gold 5.0.3222 Full Patch, You can try build your video using your photo collection from now. If you like PC software, you can bookmark this page in your browser to follow the latest updates on PC software. Please share it to your friends, using the share button facebook, twitter and google plus below this post. thanks for reading Free Download Software Proshow Gold 5.0.3222 Full Patch.


AS "THE BLACK CROWS" HAVE TAKEN STEPS TO REVITALIZE THEIR CAREERS AND RE-VIST THEIR AUTHENTIC, GRASS-ROOTS SOUND, THE BAND HAS HIRED A NEW GUITARIST.
COLORADO – Calvin the Crow has been "inducted" as the newest band member of the Black Crows. Although the band has taken quite the hiatus from the music industry, existing band members have decided to "have another go at it" and re-insert themselves back into the mainstream music scene. To boost their image and create buzz in the industry, The Band, has hired one of the best guitarists in the world.
Calvin has been playing guitar since the age of 3 months and has evolved into one of the most diverse and talented musicians in his field. His signature move is to go from playing "right-winged" to flipping his Fender Strat upside down, over his head, and strumming Jimi Hendrix style!
The Black Crows band members are thrilled to have Calvin on board!
Stay connected for upcoming tour dates.


text:
Q: Why doesn't netstat display open websites? I'm a beginner in networking and I'm checking the netstat command.
So I opened a couple websites such as en.wikipedia.org
Then I opened an admin CMD and typed netstat
I can't see this connection showing up in netstat.  I tried adding switches -n (show IP address)  and -f (show fqdn) but I can't still find this connection.
I tried refreshing the website to no avail.
I tried searching by the CNAME (dyna.wikimedia.org) to no avail
Why aren't these connections shown?
Any help much appreciated
Windows 10 20H2

A: First, netstat doesn't know the original domain name nor even the cnames – it only knows the IP address, and has to use "reverse DNS" to translate it back to some domain name.
The reverse DNS information of an IP address may actually be completely different from the regular "forward" DNS name. This is especially true for shared webhosts or CDNs with hundreds of sites per address, but can also occur even for dedicated hosts.
For example, the Wikipedia webserver's reverse DNS is text-lb.esams.wikimedia.org so that's what you should be looking for. Many Google websites use "1e100.net". Any website hosted through CloudFlare will just show up as "cloudflare", and so on.

Second, webpages are not video streams – they are documents. This means that by the time a webpage is shown on your screen, most of it has already been downloaded, and within a few seconds the HTTP connection gets closed and therefore no longer shown in netstat. Your browser just keeps the page in memory from that point.
The browser will just open a brand new connection whenever you click a link, and once the new page is downloaded and the connection goes idle, it'll soon be closed again. Some connections (especially those used for HTTP/2) may linger for minutes, but rarely forever.
So you should check netstat quickly while the webpage is still loading, or use other tools (such as Process Hacker) which give you an automatically refreshing list.
Though, browsers do allow webapps – e.g. chat apps, news sites – to keep a connection open for continuously streaming data (typically using Websockets) if that's needed. And of course, actual video streams and similar things will keep the connection open for as long as necessary. But the majority of webpages are ordinary downloaded documents.

redpajama_set_name: RedPajamaStackExchange


text:
Deficits in many major sectors a concern, Ian Lee tells CBC's The Exchange
MLI author Ian Lee says that, although it's not a gigantic worry, Canadians should be concerned about the levels of debt major sectors of the economy are carrying.
"We will have to respond to this because this is not the way to build a prosperous economy", Ian Lee told CBC's The Exchange.
Lee was responding to a recent column, written by MLI Senior Fellow Philip Cross in the Financial Post, arguing that governments and other major sectors of the economy have an unsustainable debt addiction.
Lee's interview begins at 9:24 mark.
Lee is the co-author, with MLI Senior Fellow Sean Speer, of the MLI paper "Avoiding the federal deficit quicksand".
In the Media, Latest News, Multimedia, Recent News
deficits, Ian Lee, Philip Cross, the Exchange
Youth unemployment problems confined mostly to teenagers, Cross tells CBC's the Exchange A youth unemployment crisis? No, Macdonald-Laurier Institute Senior Fellow Philip Cross tells the Exchange on...
Respect for Parliament an emerging concern at the Supreme Court, Perrin tells the Citizen Worries about treading on Parliament's policy-making function are now a subject of open debate at...
Canada should embrace its natural resources: Cross on CBC's the Exchange Canadians should stop worrying about minor setbacks such as the current slump in oil prices...
A carbon tax will have economic consequences, Cross tells BNN A carbon tax is going to have to be set high if it's going to...
Canada's prospects for long-term growth should eclipse technical recession talk, Philip Cross tells BNN The debate about whether Canada is in a technical recession or not is immaterial. What...


Modern American artist Robert Rauschenberg (1925–2008) is probably best known for his "Combines," a term he invented to describe a series of works that present found objects on canvas and therefore combine aspects of painting and sculpture. Art critic Jonathan A. Anderson and theologian William A. Dyrness address the religious references that proliferate through his oeuvre, and that of many other late nineteenth- and twentieth-century artists, in their book Modern Art and the Life of a Culture: The Religious Impulses of Modernism* (Downers Grove, IL: InterVarsity Academic, 2016), part of IVP's Studies in Theology and the Arts series. The following excerpt is taken from pages 308–9.
Robert Rauschenberg (American, 1925–2008), Untitled, ca. 1955. Oil, paper, fabric, and newspaper on canvas with string, nail, funnel, and wood, 31 1/2 × 25 1/8 × 9 in. (80 × 63.8 × 22.9 cm). San Francisco Museum of Modern Art.
Rauschenberg's Untitled black painting with a funnel (c. 1955) is presented as a kind of figure: the open circular collar of a t-shirt positions a head relatively high in the field, and the fragment of a sleeve on the right-hand edge indicates a lifted hand. Nearly all of the collaged scraps of cloth and paper on the surface are painted over in flat black paint—one of the few portions that is not is a prayer card just to the right of the center of the painting that displays a reproduction of Carl Bloch's Doubting Thomas (1881). Flurries of red, yellow, green and white paint have been slashed across the surface immediately below this image (the only place such color appears in the painting), which within the figure suggested by the cloth fragments correspond to the position of the wound in Christ's side, as depicted in the prayer card. The painting's surface subtly stands in for the wounded body of the resurrected Jesus, and as such the ball of twine placed in the funnel on the left side of the panel becomes doubly suggestive of incarnation (descending downward into the funnel) and ascension (being pulled upward out of the funnel). But if Rauschenberg is allegorizing the surface of the painting with the resurrected body of Christ, then he is also placing himself (and the viewer) in the position of the incredulous Thomas. It is a painting that powerfully articulates both a longing to touch and see (Lk 24:39; cf. Lk 6:19) and the persistence and seeming ineluctability of doubt in the age of modernity (including doubt that images, much less paintings, can any longer serve as vehicles for the kind of religious touching and seeing that we long for). Like much modern art, this is not a work of unbelief as much as it is of fragilized belief, one that is caught oscillating (or struggling) between doubt and belief.
* This is an Amazon affiliate link, meaning that Art & Theology will earn a small commission on any purchase that originates here.


text:
Erupisode: Rolling with Mr. 'Click Mi Finger'
Kreyol Chronicles: Ça CartOOne Créations
Kreyol Chronicles, our monthly look into Haitian culture as seen through the lens of Haitian photographer Christopher Mitchell, returns with a spotlight on a furniture maker who's making the most of her country's discarded goods.
Photos by Christopher Mitchell
Francoise Hazel, the craftswoman behind Haïti's Ça CartOOne Créations, was a new mother living in Guadeloupe when she met the bookshelf that changed her life.
"I was searching for eco-friendly furniture for my son's nursery and I came across a recycled cardboard bookshelf at a friend's house in Guadeloupe," Hazel recalls. "I've been obsessed ever since. A couple years later, I decided to move back to Haïti with this project in mind. When I got there and started talking about it, people wanted to order even before I had my workshop put together. So I had no choice, I had to do it."
In addition to bookshelves, Hazel produces tables, chairs and iPad holders, all using recycled cardboard found near her home in Petion-Ville. While Ça CartOOne might have its roots in Hazel's time in Guadeloupe, it is part of a burgeoning culture of "trash" art in Haïti.
"Haïti is definitely a country where recycled material art abounds," Hazel says. "There is an amazing variety of materials to be found everywhere, from tires to iron drums, cereal boxes, magazine papers, chips packages… We have a real environment problem due to the fact that we are not managing our trash properly. I hope this changes soon but until that happens, we create wonderful art from it!"
The name, she says, is a play on the French "ça cartonne" — meaning "it works!" or, loosely, "it's a success!" — and 'carton,' the word for cardboard. "The double OO's are there just for the fun of being kid-friendly," she says.
At the time of Ça CartOOne's launch, Hazel was working administrative director of Fondation AfricAmericA, a cultural foundation which promotes contemporary art in Haïti. The job gave her the opportunity to exchange techniques and ideas with local artistans. "It was a rewarding experience," Hazel says. "But I was getting more and more orders, and had less and less time to fill them."
These days, Hazel does Ça CartOOne full time, working out of a workshop in Petion-Ville. Her clientele is a mixture of Haitians who come to her looking for furniture made to order, and international customers who buy through her website. Ça CartOOne is also stocked in a handful of shops in Haïti.
"The people buying are those looking for originality and custom-made pieces," Hazel says. "A lot of them are eco-friendly enthusiasts like me, or parents searching for safe and kid-friendly furniture. Some people just like the practicality of it."
Now, you are probably asking: Just how tough and long-lasting can furniture made from cardboard, a material generally used for temporary transport of goods, be? Hazel says she uses craft paper, waterproof wood glue and varnish to protect the surfaces from liquid spills. "Furniture destined for the kitchen or the bathroom gets an extra coat of varnish," she says. While exposure to the elements is not recommended, water and juice spills can usually be wiped away with a towel or a sponge.
"People often ask if the pieces are strong enough to support weight and they also wonder about durability," Hazel admits. "I invite them to sit on them! Then I tell them about that first cardboard bookshelf I had come across in Guadeloupe all those years ago. It had been given to my friend's daughter at her birth, she is 18 years old now and the bookshelf is still standing!"
Ça CartOOne Créationscardboard furnitureFrancoise HazelHaitiHaitian artHaitiansKreyol Chroniclestrash art


the dl speed of this smartphone is so amazing over 4g, it just nice...thanks sony!
Is this support usb OTG ?
i love this sony V..superb!!and cool!!
AnonD-84831, 31 Oct 2013lol. u r taking this personally, aren't u ? just relax dude :)Not really. I just don't like know-it- all trolls roaming around to spread lies. Its kinda pathetic.
GREAT , 30 Oct 2013great price with a great quality..my battery working fine after rooted! and tweak w. my own tw... moreWhat do you mean with tweaks?have you changed the cpu?
Today i am going to tell you how to rescue xperia V no matters how much garbage you have installed on it or how many things you have format or deleted.
I brought White colour phone and its silver coating is damaged due to scratches.
they were using silver coated Plastic frame and it was really ugly when silver coated is removed.
They should have done better than this.