text:
Examining the association between blood-based biomarkers and human post mortem neuropathology in the University of Kentucky Alzheimer's Disease Research Center autopsy cohort
Zachary Winder, Tiffany L. Sudduth, Sonya Anderson, Ela Patel, Janna Neltner, Barbara J. Martin, Katherine E. Snyder, Erin L. Abner, Gregory A. Jicha, Peter T. Nelson, Donna M. Wilcock
Cardiovascular Research Priority Area
Neuroscience Research Priority Area
Sanders-Brown Center on Aging (SBCoA)
Pathology and Lab Medicine
Introduction: Clinically, detection of disease-causing pathology associated with Alzheimer's disease (AD) and vascular contributions to cognitive impairment and dementia (VCID) is limited to magnetic resonance imaging and positron emission tomography scans, which are expensive and not widely accessible. Here, we assess angiogenic, inflammatory, and AD-related plasma biomarkers to determine their relationships with human post mortem neuropathology. Method: Plasma samples were analyzed using a digital immunoassay and pathological evaluation was performed by University of Kentucky Alzheimer's Disease Research Center neuropathologists. The association of plasma markers with neuropathology was estimated via proportional odds and logistic regressions adjusted for age. Results: Included cases (N = 90) showed increased tau/amyloid beta (Aβ)42 ratio, glial fibrillary acidic protein (GFAP), vascular endothelial growth factor A (VEGF-A), and placental growth factor (PlGF) were positively associated with higher level of AD neuropathological change, while higher Aβ42/Aβ40 ratio was inversely associated. Higher PlGF, VEGF-A, and interleukin 6 were inversely associated with chronic cerebrovascular disease, while Aβ42/Aβ40 ratio was positively associated. Discussion: Our results provide support for the continued study of plasma biomarkers as a clinical screening tool for AD and VCID pathology.
https://doi.org/10.1002/alz.12639
Funding for the studies described was provided by NIH grants P30AG072946 (DMW, ELA, GAJ, PTN), UH3NS100606 (DMW, GAJ), F30NS118777 (ZW). The authors are grateful for our UK‐ADRC research participants for their dedication to the study of dementia.
© 2022 the Alzheimer's Association.
amyloid beta
10.1002/alz.12639
Dive into the research topics of 'Examining the association between blood-based biomarkers and human post mortem neuropathology in the University of Kentucky Alzheimer's Disease Research Center autopsy cohort'. Together they form a unique fingerprint.
Alzheimer's Disease Medicine and Dentistry 100%
Plasma Medicine and Dentistry 66%
Neuropathology Medicine and Dentistry 50%
Biological Marker Medicine and Dentistry 50%
Pathology Medicine and Dentistry 33%
Dementia Medicine and Dentistry 33%
Cognitive Defect Medicine and Dentistry 33%
Winder, Z., Sudduth, T. L., Anderson, S., Patel, E., Neltner, J., Martin, B. J., Snyder, K. E., Abner, E. L., Jicha, G. A., Nelson, P. T., & Wilcock, D. M. (2023). Examining the association between blood-based biomarkers and human post mortem neuropathology in the University of Kentucky Alzheimer's Disease Research Center autopsy cohort. Alzheimer's and Dementia, 19(1), 67-78. https://doi.org/10.1002/alz.12639
Winder, Zachary ; Sudduth, Tiffany L. ; Anderson, Sonya et al. / Examining the association between blood-based biomarkers and human post mortem neuropathology in the University of Kentucky Alzheimer's Disease Research Center autopsy cohort. In: Alzheimer's and Dementia. 2023 ; Vol. 19, No. 1. pp. 67-78.
@article{b9036b632cac4608a8339e3ff6760af0,
title = "Examining the association between blood-based biomarkers and human post mortem neuropathology in the University of Kentucky Alzheimer's Disease Research Center autopsy cohort",
abstract = "Introduction: Clinically, detection of disease-causing pathology associated with Alzheimer's disease (AD) and vascular contributions to cognitive impairment and dementia (VCID) is limited to magnetic resonance imaging and positron emission tomography scans, which are expensive and not widely accessible. Here, we assess angiogenic, inflammatory, and AD-related plasma biomarkers to determine their relationships with human post mortem neuropathology. Method: Plasma samples were analyzed using a digital immunoassay and pathological evaluation was performed by University of Kentucky Alzheimer's Disease Research Center neuropathologists. The association of plasma markers with neuropathology was estimated via proportional odds and logistic regressions adjusted for age. Results: Included cases (N = 90) showed increased tau/amyloid beta (Aβ)42 ratio, glial fibrillary acidic protein (GFAP), vascular endothelial growth factor A (VEGF-A), and placental growth factor (PlGF) were positively associated with higher level of AD neuropathological change, while higher Aβ42/Aβ40 ratio was inversely associated. Higher PlGF, VEGF-A, and interleukin 6 were inversely associated with chronic cerebrovascular disease, while Aβ42/Aβ40 ratio was positively associated. Discussion: Our results provide support for the continued study of plasma biomarkers as a clinical screening tool for AD and VCID pathology.",
keywords = "amyloid beta, angiogenesis, cerebrovascular, dementia, inflammation, tau",
author = "Zachary Winder and Sudduth, {Tiffany L.} and Sonya Anderson and Ela Patel and Janna Neltner and Martin, {Barbara J.} and Snyder, {Katherine E.} and Abner, {Erin L.} and Jicha, {Gregory A.} and Nelson, {Peter T.} and Wilcock, {Donna M.}",
note = "Funding Information: Funding for the studies described was provided by NIH grants P30AG072946 (DMW, ELA, GAJ, PTN), UH3NS100606 (DMW, GAJ), F30NS118777 (ZW). The authors are grateful for our UK‐ADRC research participants for their dedication to the study of dementia. Publisher Copyright: {\textcopyright} 2022 the Alzheimer's Association.",
doi = "10.1002/alz.12639",
Winder, Z, Sudduth, TL, Anderson, S, Patel, E, Neltner, J, Martin, BJ, Snyder, KE, Abner, EL, Jicha, GA, Nelson, PT & Wilcock, DM 2023, 'Examining the association between blood-based biomarkers and human post mortem neuropathology in the University of Kentucky Alzheimer's Disease Research Center autopsy cohort', Alzheimer's and Dementia, vol. 19, no. 1, pp. 67-78. https://doi.org/10.1002/alz.12639
Examining the association between blood-based biomarkers and human post mortem neuropathology in the University of Kentucky Alzheimer's Disease Research Center autopsy cohort. / Winder, Zachary; Sudduth, Tiffany L.; Anderson, Sonya et al.
In: Alzheimer's and Dementia, Vol. 19, No. 1, 01.2023, p. 67-78.
T1 - Examining the association between blood-based biomarkers and human post mortem neuropathology in the University of Kentucky Alzheimer's Disease Research Center autopsy cohort
AU - Winder, Zachary
AU - Sudduth, Tiffany L.
AU - Anderson, Sonya
AU - Patel, Ela
AU - Neltner, Janna
AU - Martin, Barbara J.
AU - Snyder, Katherine E.
AU - Abner, Erin L.
AU - Jicha, Gregory A.
AU - Nelson, Peter T.
AU - Wilcock, Donna M.
N1 - Funding Information: Funding for the studies described was provided by NIH grants P30AG072946 (DMW, ELA, GAJ, PTN), UH3NS100606 (DMW, GAJ), F30NS118777 (ZW). The authors are grateful for our UK‐ADRC research participants for their dedication to the study of dementia. Publisher Copyright: © 2022 the Alzheimer's Association.
N2 - Introduction: Clinically, detection of disease-causing pathology associated with Alzheimer's disease (AD) and vascular contributions to cognitive impairment and dementia (VCID) is limited to magnetic resonance imaging and positron emission tomography scans, which are expensive and not widely accessible. Here, we assess angiogenic, inflammatory, and AD-related plasma biomarkers to determine their relationships with human post mortem neuropathology. Method: Plasma samples were analyzed using a digital immunoassay and pathological evaluation was performed by University of Kentucky Alzheimer's Disease Research Center neuropathologists. The association of plasma markers with neuropathology was estimated via proportional odds and logistic regressions adjusted for age. Results: Included cases (N = 90) showed increased tau/amyloid beta (Aβ)42 ratio, glial fibrillary acidic protein (GFAP), vascular endothelial growth factor A (VEGF-A), and placental growth factor (PlGF) were positively associated with higher level of AD neuropathological change, while higher Aβ42/Aβ40 ratio was inversely associated. Higher PlGF, VEGF-A, and interleukin 6 were inversely associated with chronic cerebrovascular disease, while Aβ42/Aβ40 ratio was positively associated. Discussion: Our results provide support for the continued study of plasma biomarkers as a clinical screening tool for AD and VCID pathology.
AB - Introduction: Clinically, detection of disease-causing pathology associated with Alzheimer's disease (AD) and vascular contributions to cognitive impairment and dementia (VCID) is limited to magnetic resonance imaging and positron emission tomography scans, which are expensive and not widely accessible. Here, we assess angiogenic, inflammatory, and AD-related plasma biomarkers to determine their relationships with human post mortem neuropathology. Method: Plasma samples were analyzed using a digital immunoassay and pathological evaluation was performed by University of Kentucky Alzheimer's Disease Research Center neuropathologists. The association of plasma markers with neuropathology was estimated via proportional odds and logistic regressions adjusted for age. Results: Included cases (N = 90) showed increased tau/amyloid beta (Aβ)42 ratio, glial fibrillary acidic protein (GFAP), vascular endothelial growth factor A (VEGF-A), and placental growth factor (PlGF) were positively associated with higher level of AD neuropathological change, while higher Aβ42/Aβ40 ratio was inversely associated. Higher PlGF, VEGF-A, and interleukin 6 were inversely associated with chronic cerebrovascular disease, while Aβ42/Aβ40 ratio was positively associated. Discussion: Our results provide support for the continued study of plasma biomarkers as a clinical screening tool for AD and VCID pathology.
KW - amyloid beta
KW - angiogenesis
KW - cerebrovascular
KW - dementia
KW - inflammation
KW - tau
U2 - 10.1002/alz.12639
DO - 10.1002/alz.12639
Winder Z, Sudduth TL, Anderson S, Patel E, Neltner J, Martin BJ et al. Examining the association between blood-based biomarkers and human post mortem neuropathology in the University of Kentucky Alzheimer's Disease Research Center autopsy cohort. Alzheimer's and Dementia. 2023 Jan;19(1):67-78. doi: 10.1002/alz.12639


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Remember way back when I made my national citrus fruit appeal? Actually I think it was a global citrus fruit appeal. Well either way it was epic, okay?
Remember when I then preserved some Meyer lemons for a rainy day?
Well today is that rainy day.
It's high time we use those preserved lemons, don't you think? I know some of you have them in your cabinets, you told me so.
Time to give them a rinse and make something out of them. I choose chicken tagine. Because I love it and it reminds me of my days cooking in France when I made this in little cast iron pots and it was sizzling and made the room smell like Morocco.
Here is a little video I did on the topic which shows you the steps. It's from my Modern Pioneering YouTube Series which I hope you will subscribe to! It shares all kinds of tips, trick, recipes and life hacks like this.
Here are some of the things you will need: Chicken, carrots, zucchini, peppers, preserved lemons, cumin, turmeric, saffron, ginger, olive oil, lemon for juicing.
Simply dig two lemon halves out of the wet salt.
Then rinse them well under cold water. You want to rinse all of the salt off.
Then lay them on a cutting board.
Then you slice them in half and remove the pulp.
Or you can keep going and cut them into a nice dice.
Then you cut up all of your vegetables and quarter the chicken. You also grate the ginger, squeeze the juice of a lemon and mince some garlic.
See how the vegetables are cut into two inch pieces with diagonal ends? That's because I used to do it that way in France and it's programmed into my DNA. You don't have to do it that way if you don't want to. I would suggest keeping them relatively large though so they don't overcook.
Then you add the vegetables and olive oil.
Then you stir it all very well.
Then you add a few pieces of saffron. This saffron is from Washington state! It's a rare thing. It was a gift from Jon Rowley when I went to write about it for my book.
This is going to refrigerate for at least an hour so that all of the flavors meld.
Then you get a skillet very hot.
You want to brown the chicken pieces nicely on both sides.
And this stews into a glorious, sultry Moroccan tagine that will make your heart go pitter patter.
Combine all of the ingredients into a bowl and let marinate for 20-30 minutes.
Heat a tagine, large skillet, or heavy bottom casserole dish until very hot. Brown the chicken parts in a bit of olive oil until browned on both sides, about 5 minutes.
Add the vegetables and saute with the chicken.
Deglaze the pan with the marinade from the bowl and then lower the heat. Cook covered on low heat or in the oven at 350 degrees for 45 minutes.
one of the few ways in which I'll eat zucchini. sounds amazing!
There's actually a quick way to preserve lemons where you take: 1 cup water, 2 tablespoons kosher salt and 2 lemons, washed and quartered, then you just bring the salt water to a boil and add the lemons for 30 minutes until they're tender. You can cool them and use them right away!
Ooo! I have been craving tagine since I left Boston and my favorite Algerian/Tunesian place. Have you have karantita with harissa, by the way? It is chickpea custard that is amazing and super easy.
(a) I don't eat chicken. Is there a way to make this with fish?
(b) If one (still) does not own a cast iron pan, what would you recommend making this in?
Also, if you need more lemons, my Mom's bush has the sweetest, most delicious lemons I have ever found.
1. I always need more lemons! 2. I have never had this custard but I am obsessed with both chick peas and custard independently. Where do I find out more? 3. Yes, you can use fish or lamb, the first you would cook for much less time and perhaps start the vegetables earlier than the fish. You don't need cast iron, anything will do.
I'm from washington, born and raised, but never knew we had any saffron hiding around here. I love the step by step system you use with your recipes. It makes them very approachable like the Pioneer Woman's recipes.


text:
Tag Archives: Hermes Birkin bag
by minh-ha t. pham | May 31, 2012 · 12:01 am
A Pyre to Privilege, Not An Invitation to Gendered Shaming
Clint Eastwood's teenage daughter Francesca and her photography boyfriend Tyler Shields (who seems to have a thing for images of beaten-up looking women like this one of a blooded Lindsay Lohan and this one of a bruised up Heather Morris) have made news with their latest art project in which they "demolish a $100,000 crocodile Hermès Birkin bag by setting it on fire before taking a chainsaw to it."
There is a lot to criticize about this art project. Most egregious for me is its utter tone deafness with regard to fashion's impact on the environment and the exploitative and dangerous conditions in which such luxury items are manufactured.
To begin, leather products (produced from greenhouse gas-emitting cows that are a leading cause of global warming) must be treated with a toxic chemical cocktail of sodium sulfide, sodium hydroxide, sodium hydrosulfite, arsenic sulfide, calcium hydrosulfide, dimethyl amine, sodium sulphydrate, and sulphuric acid. The tanning process is so harmful to the environment that "many old tannery sites cannot be used for agriculture. Tanneries not only often poison the land they are situated on, but also the waterways into which they discharge effluent."
Moreover, industrial tanning is seriously harmful to the health of workers who have to oversee the poisonous process. By and large, these workers are low-wage and highly concentrated in the Global South (mostly in Nepal, Bangladesh, and India, but also in Southeast Asia, South America, and Africa). Most tannery workers suffer from back pain, asthma, dermatitis, and chronic bronchitis; all workers are at elevated risks for developing cancer of the bladder, the respiratory system, and the reproductive system. Studies have also found that greater numbers of tannery workers develop premature dementia. As compensation, workers get paid about US$100 per month. In other words, the very people who are making and literally dying for these products, cannot afford to own them. Meanwhile, elites like Eastwood and Shields benefit from the high symbolic value of luxury products without suffering any of the costs. (Neither of their lungs nor their drinking water is contaminated by the cancer-inducing toxins that went into making the Birkin they so gleefully and publicly destroy.)
Yet given the inarguably damaging conditions and effects of tanneries that produce luxury products like this $100,000 Birkin bag, I'm reluctant to judge people for buying them. Let me explain why. Most products in the mass and luxury markets are manufactured in harmful conditions that have deleterious effects on the environment and the people who work and live near the facilities. Fashion is not the only or even worse contributor to environmental racism, labor exploitation, and global warming. Commodities and services that pack a larger eco-punch, for example, are air travel, bottled water, and disposable razors. Yet fashion consumers are easy scapegoats. They're already perceived as frivolous, wasteful, and stupid conspicuous consumers whose feminine vanity leads them to participate in irrational and irresponsible consumer practices that are the cause of All Of The World's Problems. The gendered subtext that always lurks behind this finger wagging is why I'm turned off by fashion-shaming of all stripes and sizes. (While Shields is as responsible for this art project as Eastwood, because it's her body that we see in the photographs and because fashion is almost automatically associated with women, she's received a disproportionate amount of the criticism. Commenters have used a myriad of sexist epithets to deride Eastwood.) Seldom is this kind of moralizing and shaming lodged at consumers of luxury cars, personal technologies, homes, and vacation packages even as all these luxury items have adverse effects on the local environments and economies in which they're produced.
It's less relevant here but one more reason I find fashion-shaming an uncompelling critical approach is the ways in which conspicuous consumption ideology has been unevenly and asymmetrically applied to people of color across the class and gender spectrums. (I discuss this a bit more here.)
None of this is meant to excuse the awful conditions in which leather is processed and manufactured. Just so that my position is clear: I believe all workers should be paid a living wage, that protective clothing (HAZMAT-level, if necessary) is part of the job-related equipment for which employers are solely responsible, that adequate and affordable healthcare is a human right, and that companies should be legally and financially obligated to make sure that the land, air, and water that these workers and their families depend on – to live – is safe. My aunt worked in a computer chip plant in southern California where, as we found out after her death to lung cancer, she had no access to fresh air or ventilation during the 10-12 hours she spent there each working day. (She never smoked a day in her life.) My position on improving labor conditions for all low wage workers, a predominantly ethnic labor force, is both political and personal.
But I have no truck with fashion-policing or morality-policing. I'm more interested in critiquing the structures of wealth and wage inequality and the systemic practices of financial companies that have resulted in the racial disparity in credit card debt that give shape to the differential meanings, possibilities, and relations to consumption for marginalized people.
So rather than moralizing about conspicuous consumption, I think a more compelling critique of Eastwood and Shield's art project is one that focuses on their obnoxious glorification of conspicuous wastefulness. For me, their wanton destruction of this luxury handbag demonstrates their total apathy, ignorance, and disrespect for the human and environmental costs that went into its manufacture. Certainly, "the post-consumption life" of this bag (h/t Jessamyn Hatcher) might have been extended in numerous other useful or at least less insulting ways. For example, if they no longer wanted the handbag, why not sell it and donate the proceeds to their favorite sweat-free labor organization or cancer-research charity? What bothers me about this art project is not the flaunting of wealth via conspicuous consumption but rather the flouting of "the possessive investment in whiteness" (George Lipsitz's eminently useful term for the privileged relationship between whiteness and asset accumulation, attitudes and material interests).
I have no idea what the intended message of their art project is – I could probably Google it but honestly, I don't care. The message received, at least as far as I'm concerned, is that in the midst of one the worst global economic recessions in which, according to a 2012 report by the International Labor Organization in Geneva, Switzerland "one in three workers in the labour force is currently either unemployed or poor [and] that out of a global labour force of 3.3 billion, 200 million are unemployed and a further 900 million are living with their families below the US$2 a day poverty line" these two young people are flaunting their social privileges. These structural privileges are not only unearned but apparently in excess since they obviously have money to burn. Talk about tastelessness.
Just added (10:17AM EDT)
Almost immediately following the publication of this post, my favorite Jezebel writer Jenna Sauers and I engaged in some late night behind the blog bandying about this post, her post, and a bunch of other thoughts we had about the authenticity of the story and its larger implications. I'm posting it here because (a) I think back screen chatter like this one is part and parcel of social media dialogue and (b) I just discovered Storify and I wanted an opportunity to use it.
Late Night Read: A blog post on burning Biirkins & conspicuous wastefulness http://bit.ly/MZyc9V
Minh-Ha T. Pham
Thu, May 31 2012 00:21:53
@minh81 "I have no idea what the intended message of their art project is." Sadly, I think their gesture has no artistic content whatsoever.
Jenna Sauers
@jennasauers Just read your response. "As owners of Birkin, they could dispose by whatever means"; their chosen means says a lot, no?
@minh81 Q: Was it real? Exotic Birkins on the secondary market *can* command $100k, thx to artificial scarcity, but the origin story…fishy
@jennasauers lol, totally agree! entire story is suspect. their art project rests (as art & fashion often does) on symbolic value & meanings
@minh81 And let us not forget, Tyler Shields was "poor" as recently as six years ago. He'd simply never seen such beautiful Birkins before!
@jennasauers Poor one day & $$ to burn 6 yrs later in worst economic recession. Apparently, he knows something abt American Exceptionalism.
Edited to add (10:32AM EDT):
And the story continues: US Weekly is now reporting that Shields "has made a pledge that should appease those who are quick to remind him of the starving population across the globe." (Ahem)
So sayeth he:
The Birkin photos are for sale. If somebody were to buy…all right, let's do this. If somebody wants to buy one of the Birkin photos, I will donate $100,000 — not to a charity — but to a family. I will give one family in need $100,000 cash.
Filed under (AD)DRESSING GENDER & SEXUALITY, FASHIONING RACE, STYLE POLICE & STYLE GURUS
Tagged as conspicuous consumption, conspicuous wastefulness, Hermes Birkin bag, the possessive investment in whiteness

redpajama_set_name: RedPajamaCommonCrawl


text:
Last weekend students were filmed at a large party, and local residents have reported seeing increasing numbers of students return to the city
Anita Merritt
An investigation has been launched by the police following the party (Image: Submitted/Instagram)
A number of Exeter University students caught partying in halls of residence have been fined by police for ignoring Covid-19 regulations, and have received a formal warning by the university.
An investigation was launched by Devon & Cornwall Police after a video circulated on social media showing a large party at Lafrowda which is one of the university's own on-campus accommodation buildings off St German's Road.
The video, filmed last Saturday night, showed dozens of students dancing and partying, and groups of people are seen huddled together jumping up and down in the densely-filled room.
The incident is also being investigated by the university who had said it will take any necessary disciplinary action.
Alarmed local residents have told Devon Live have they have seen increasing numbers of students within the past week and are fearful for the safety of the local community and rising coronavirus case numbers, especially after the incident at the weekend.
A spokesperson for Devon and Cornwall Police said: "A local policing unit attended Lafrowda halls of residence within Exeter University late on Saturday night, January 9.
"On attendance, the reported gathering had largely dispersed but officers spoke to a number of students along with support from University Estates Patrol.
"We have since reviewed body-worn video and liaised with the university on this matter and at this time we have issued £200 fixed penalty notices to three students.
"This matter now sits with the university in relation to their own their own disciplinary procedures and any subsequent action against those who attended the party."
Much-loved Billy, 22, died after falling off jet ski
No new Covid-19 deaths in Devon and Cornwall's hospitals
Last September and October, Covid cases at the university continued to rise – at one stage leading to Exeter having the seventh highest infection rate in England.
As it was concentrated around the university whose students were told not to mix, the area was not considered for a 'local lockdown'
Current government guidance enables some students to return, such as those who are training to be doctors, nurses, teachers and engineers.
The vast majority of students are said to be continuing to study online though and will return when government guidance allows.
An investigation has been launched by the police and officials at the University of Exeter (Image: Submitted/Instagram)
However, the university has clarified many students will have stayed in Exeter through the Christmas period or returned to the city before guidance changed, or that Exeter is their primary home.
Any students returning are required to get two Covid-19 tests, and the university has its testing facilities and support in place.
Today, Mike Shore-Nye, registrar and secretary of the University of Exeter has written to students, following the incident on the weekend.
He said: "We have been made aware of a very concerning and disappointing incident on Saturday night, when Devon and Cornwall Police attended a party at a student flat on our Streatham campus.
"The students involved were spoken to by the police who are considering what steps will follow. The university is also investigating and will take any necessary disciplinary action.
"This incident is incredibly disappointing and distressing. It undermines the best efforts of all our students and staff who are working extremely hard to keep our community safe, through engaging with Covid-19 testing, adhering to the Covid-19 rules and supporting each other and those around us.
"You cannot leave your home to meet socially with anyone you do not live with or are not in a support bubble with and gatherings of multiple households are currently illegal.
"Incidents like this will cause concern and worry amongst the Exeter community who, up until this point, have been supportive of the work that we have done together to manage the challenges of the pandemic.
Police using ANPR to catch Covid-19 rule-breakers
Covid restrictions won't ease until end of summer, Devon expert predicts
"Incidents of this nature seriously undermine the relationship between the university, our students and our friends and neighbours in the city and region. They impact not only those involved, but also all of our students and staff.
"I ask everyone reading this to reflect on this incident and to consider the words of the chief medical officer for England, who this week described how the NHS is facing 'the most dangerous time anyone can remember',and reminded us that we must all adhere to the lockdown rules to protect the NHS and save lives.
"Any repeat of this sort of incident will risk further transmission of Covid-19 and will further delay any return to normal life and normal operations for our community and those around us."
You can stay up-to-date on the top news near you with DevonLive's FREE newsletters – find out more about our range of daily and weekly bulletins and sign up here or enter your email address at the top of the page.
One resident, who lives in the Pennsylvania area of Exeter, says she has noticed the number of students increasing over the week and that when she approached three female students they admitted there were not future critical workers who had been allowed to return to their studies.
She said: "It turned out that two were studying geography and the other history. When I quizzed them about this it turned out that one of them had returned on January 5 to 'test the water' and see if she could get in.
"She openly stated that she was not challenged in any way by the accommodation reception who simply allowed her back without question. On finding that they could return unchallenged, the other two had travelled back on the Wednesday - after Lockdown.
"I asked if any more of their friends would be coming back, and one girl replied that they shared information on WhatsApp and now this information is out, hundreds of students have said they are coming back because they don't want to spend lockdown with their parents so they are coming back to party.
"One of the girls said that the university can't and won't do anything because if they don't let them back into their rooms they will have to refund their accommodation costs. When asked about getting caught travelling they simply didn't care and stated that they would only get a warning and even if they got a fine it's still better than being at home.
"A member of the security staff informed me that they had been told to expect at least 50 percent of students will return over the weeks to come.
"I am aware that foreign students, permanent residents, future critical workers etc all have a right to be on campus. However, the university seem to be turning a blind eye to those wanting to return to have a whale of a time partying for the next two plus months.
"Most of these students are coming from London and the Home Counties - currently the most severely affected areas in the country. How is this right in any way shape or form?
"While I know that most students are responsible, they are most likely the ones that have stayed put and playing their part. This minority are the ones that want to party through lockdown and are most likely to spread the virus.
"This needs to be stopped before it gets out of hand."


text:
Home»DEBRIS CLEANUP»Myakka City residents still in need of help after Hurricane Ian
Myakka City residents still in need of help after Hurricane Ian
Manatee County, Florida — Given the amount of damage left behind by Hurricane Ian's aftermath, it could take months to remove and years to rebuild. Federal and state resources have rushed into southwestern Florida's worst-hit counties, but some residents of the neighborhood between Hardy and Manatee counties feel overlooked. said.
The quiet countryside of Myakka City lies just south of the Mosaic Phosphate Mine known as Myakka Head.
"There are still many people who need help. Seniors have trees in their yards that they can't afford to do and can't pay to remove," explained Myakka homeowner Pamela Boyd.
Boyd drove a 45-minute drive to the FEMA Disaster Recovery Center, now the closest in Bradenton, for help.
wfts
"I have an 82-year-old woman, she has cancer, and I've known her for a while, and now it's overpowering her," Boyd said. The roof is leaking, we have over 13 trees in the yard that we have to take out…and we can't afford to pay to finish it all."
Boyd said a FEMA representative gave a neighbor the number of a volunteer-based crisis hotline.
Boyd explained that many residents of Myakka were cut off when cell towers and internet services went down.
Stassy Olmos, an in-depth reporter for ABC Action News, ran out of her home off State Route 64 and Duet Road to meet homeowner Garrett Lamy.
"There was no communication here. Sprint and T Mobile are still down," Ramy said.
He still has trees and power lines in his yard.
"There is damage to the roof of the house and damage to the barn," Lamy said. "We are looking at about $100,000 in property damage and about $20,000 in personal property loss.
Lamy's insurance company tarps his house and barn roof, but he said many residents are retired and cannot afford the insurance.
"My neighbor here… Look, he, he lost a lot. His roof is also leaking. He does not have homeowners insurance. As you know, his income is very limited," he explained.
He added that there were questions left unanswered at the county's community meeting in early November.
"for example, The Army Corps of Engineers roof program was not available," Lamy said. "Also, the governor's … $5 million program that was supposed to help homeowners get exempt from insurance deductibles wasn't available in Manatee County."
In addition to the damage, Manatee County notified Myakka residents on October 13 that it found that "a significant number of private wells in the area have been contaminated by floodwaters."
They set up free water, showers and laundry at the Myakka Community Center and also provided free water testing through the Manatee Health Department.
Boyd said the whole thing is taking a toll on the mental health of residents.
""They need volunteers and crew members who have some help to help people," said Boyd. increase.
Olmos We reached out to agencies involved in disaster response, from FEMA to the Governor's Office, to ask what was being done for Manatee residents who still needed help.
The governor's office has sought contact information for the residents we spoke with so they can get in touch and find out what their exact needs are.
When asked about financial insurance deductible assistance available in certain counties, the governor's office did not respond, but in the initial release announcing the funding, Governor Ron DeSantis said it was "the hardest hit." It was found that it was for Ian's victims who lived in "the counties of Charlotte, Collier, DeSoto, Hardy, Lee, and Sarasota."
A Manatee County spokesperson said FEMA had been at the Myrkka Community Center for several weeks, but residents should visit the FEMA Disaster Recovery Center in Brandenton's John Marble Park, the same place Boyd and his neighbors frequented. Stated.
FEMA's external relations are based on what Manatee residents call the Personal Assistance Program, which provides rental assistance and housing for displaced people, and a program to make their homes "safe, hygienic, and functional." He said he was qualified to provide funding.
FEMA funds the Army. Free tarp for roofs after natural disasters and select eligible counties as required by state emergency management. According to a FEMA spokesperson, the criteria include the number of structures and the number of buildings that "can be habitable with the blue roof program."
We also spoke with Kevin Guthrie, director of Florida's Emergency Management Division (FDEM). He explained that the manatee may be turned over to a volunteer organization because he is not in a county eligible for private property debris removal assistance by FEMA.
"Your best option at this time is to contact your insurance company. If your insurance company doesn't cover it, contact your local emergency management agency so they can work with local nonprofits in Manatee County and possibly your area to help you. .
For Southwest Florida residents who still need to pick up debris, the FDEM is still pending.
"We're not looking for government subsidies…but what we're looking for is approval," Ramy exclaimed.
The latest well test from the Manatee Department of Health, obtained on November 14, shows 553 mapped wells tested.
353 is satisfied
156 people are not satisfied
44 are still contaminated
As the wells are privately owned, it is the responsibility of each resident to clean and disinfect the wells after flooding.
We asked Manatee County Information Outreach Manager Bill Logan and Manatee DOH what they're finding in the water.
In an email, Logan said, "When wells are flooded, floodwaters enter the wells and can cause bacterial contamination. Bacterially contaminated wells can cause digestive disorders such as diarrhea and vomiting when the water is consumed." It can also lead to infection of open wounds used for bathing and showering.The only way to be sure the water is safe is to test it for coliforms, Testing for coliforms FDOH- Manatee provides residents with sterile sample bottles and instructions on how to take samples from wells Residents send to state-accredited labs for analysis We have established a collection point to bring samples in. Once the lab has completed the analysis, we will provide the results to the residents.Well, the results that no bacteria are present are bacteriologically safe."
I asked if chemicals from the phosphate mines near Mosaic were of concern.
"No. The investigation is for bacteriological contamination," Logan clarified.
The only public notice of contamination reports from Hurricane Ian from Mosaic on the Florida Environmental Protection Agency website is a September 30, 2022 submission from Four Corners Mine.
"Continuous stormwater discharge from the facility's Stormwater BMP was discovered during post-storm investigations as a result of excessive rainfall and regional scale flooding during and after Hurricane Ian. Due to the ongoing flooding, access to the site remains restricted."
The Florida Emergency Management Agency also said it would send experts to test about 200 private wells, but the mission was delayed because of Hurricane Nicole.
To contact the Manatee County Emergency Management Office, call (941) 749-3500 or email emdo@mymanatee.org.
The Myakka City Community Center is located at 10060 Wauchula Rd in Myakka City. The facility will be open from 9:00 am to 6:00 pm until the well is safe for use.
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text:
131 goals and 72 Assists: See The Season That Barcelona's 'MSN' Were The Best Force
By Tobewilly (self media writer) | 6 months ago
Barcelona are one of the most successful teams in Europe with 5 Champions league, 4 UEFA Cups, 5 UEFA Super Cups, and 3 FIFA Club World Cup trophies to their name. In Spain, they are the number one team in terms of achievements, having 26 La liga titles and 31 Copa del Rey Cups.
Getting to this height was never a thing of luck for them, they have intentionally brought great and talented players like Ronaldinho, Samuel Eto, David Villa, Lionel Messi, Neymar, Luis Suarez and many others into the club to help in the quest for greatness.
Messi joined Barcelona at the age of 13, but made his senior team debut in the October, 2004. Brazilian star Neymar was signed by the La liga giants on the 1st of July, 2013 for a fee worth around €88.20 million. One year later, on the 11th of July, 2014 a whooping €81.72 million was paid for the services of Luis Suarez.
These signings brought about the emergence of the acronym "MSN" meaning "Messi, Suarez and Neymar". Between 2014 and 2017, these three were terrors to so many defence lines in Europe, and were arguably the best attacking force. They scored so many goals and won so many titles together, but that of the 2015/2016 season was just phenomenal. These three were firing on all cylinders.
For Messi, he scored a total of 41 goals and recorded 24 assists in 49 games. In La liga he had 26 goals and provided 16 assists, 6 goals and 1 assist in the Champions League, 5 goals and 6 assists in the Copa del Rey, 1 goal each in the SuperCopa and FIFA Club World Cup, 2 goals and 1 assist in the UEFA Super Cup.
For Luis Suarez, he scored a astonishing 59 goals and supplied 23 assists in 53 appearances. According to the various competitions, 40 goals and 18 assists in La liga, 8 goals and 3 assists in the Champions League, 5 goals and 1 assist in the Copa del Rey, 5 goals in the Club World Cup and a goal and an assist in the UEFA Super Cup.
Although he was the least among them, Neymar's numbers were as well impressive. The Brazilian scored a total of 31 goals and provided 25 assists in 49 appearances that season. 24 goals and 16 assists in La liga, 3 goals and 5 assists in the Champions League, 4 goals and 2 assists in the Copa del Rey and 2 assists in the FIFA Club World Cup.
That 2015/2016 season, Barcelona won the La liga, Copa del Rey, UEFA Super Cup and FIFA Club World Cup under the leadership of Coach Luis Enrique, an end product of the MSN's blistering performance.
Do you think that they were the best attacking trio the world of football have ever witnessed?
Content created and supplied by: Tobewilly (via Opera News )
Barcelona FIFA Club World Cup La liga MSN Neymar


text:
Photography and travel, by Dave Perkes
The images are just a sample of some of the amazing places in Asia that has been my good fortune to have visited. My first visit to India in 1993, opened my eyes to this fascinating continent. I have been running photo tours around SE Asia for over 10 years. This website concentrates on wider areas of Asia and my travels around the Region.
HOME - CAMBODIA - LAOS - INDIA - MALAYSIA - MYANMAR - THAILAND - VIETNAM
Phillipines: North Luzon
The incredible landscapes of North Luzon which I visited in January 2019
Phillpines New Page
Turkey: Turquoise coast and Istanbul
8Bridging the continents of Europe and Asia; Turkey has a fascinating history. My images from 2018 show my trek along the famous Turquoise Coast of Anatolia with the gorgeous coastline and spectacular city of Istanbul.
West Papua and The Bailam Festival
at Wamena in the centre of Papua
In August 2015 I co-led a photo tour to West Papua with Indonesian photographer Rizky Nurraman Arashid.
The festival was an incredible way to see the culture of the Tribes in West Papua, who live lives largely untouched by modernity.
I was able to get out to a few villages to see at first hand how these people live.
This was a "National Geographic" experience of a lifetime. To go to West Papua is something never to be forgotten; but you need to be flexible and understand this is not a normal tourist destination!
I lived and worked as a photographer in Cambodia from 2003 until 2017 so have thousands of images of this wonderful country.
Cambodia is a photographic paradise with spectacular sites and lovely people.
The Angkor Temples are amazing; but its the people & rural life which have been an endless fascination for me as a photographer.
Cambodia and SE Asia Tours
Running photo tours have been an important part of my life here in Cambodia and SE Asia in the the last ten years.
Peace Of Angkor Tours. originally set up by me, is now run by my colleagues and friends Doun Raden and Ta Elit .
If you want Photo Tours in Cambodia PEACE OF ANGKOR are the best.
For more information on Peace Of Angkor Tours and to make booking enquiries see here
Travel and Photography in Asia and Beyond
Dave in the Remote settlement of Cook in the centre of the Nullabor plain
Australia is a huge country which deserves a full website on its own. I've travelled extensively here since 2010. My most recent trip was in March 2016 Crossing Australia on the Indian Pacific Railway from Perth to Sydney via Adelaide.
Mountains have been a passion of mine for many decades. Nepal is a Mecca for the mountaineer and trekker. The lovely Himalayan foothills people and Hindu Culture in the Historic cities; are equally fascinating for travellers and photographers.
Cambodia's near neighbour is a fascinating country with a lot to interest the visitor.
With the tropical Mekong Delta in the south, to the temperate highlands in the north towards China. Vietnam has a diverse climate and landscape which is the most spectacular in SE Asia.
Its been a while since I last visited India. However the trips I had there were almost life changing. India is a continent in itself with such contrasts in wealth and poverty. Its a place which people love it or hate it. There is nothing average about this country. That reflects in the incredible photography there.
Tribesmen at the Bualem Valley Festival in West Papua
Indonesia has thousands of Islands and the most diverse landscapes of all of Asia. its impossible to see it all so I have concentrated on Jakarta. Flores and West Papua.
Laid back and friendly the Lao People are what have drawn me to the country time and time again.
Buddhist culture is a very important part of life here with temples and impressive landscapes.
I have only been to Burma once in 2012. It was one of the most Amazing three weeks I have ever spent in SE Asia.
Bagan is temple heaven, with the largest concentration of ancient monuments on this planet. Not only that, the Burmese people, landscape and British Colonial architecture are equally as fascinating.
Malaysia
Malaysia is one of the fastest growing economies in SE Asia. Its modern cities reflect that.
Behind it all is a land shaped by Islamic, Chinese and European influences. The Chinese, Portuguese, Dutch and British have left their mark on this large country which encompasses a large part of the Island of Borneo.
Dave taking a selfie the hard way in Annaprnas
About Dave Perkes
Dave's passion for photography started in the mid 1970s while working as a cartographer in Southampton England. Dave's early interest in photography was motor sport then landscape and mountains. People became increasingly important subjects from the late 1980s, when Dave travelled beyond Europe to North Africa, Asia and the Indian Sub continent.
Having spent 12 years working in digital cartography; Dave developed an interest in digital photography in the mid to late 1990s. An early adopter of the digital SLR; Dave purchased his first digital SLR camera system early in 2003; shortly before moving to Siem Reap Cambodia in May of that year.
Dave and his partner Colleen Allan-Burns set up Peace of Angkor Villa as a small hotel catering for photographers, artists and writers. It was an exciting time meeting a lot of very interesting and creative people. He dedicated a lot of time in the mid 2000s discovering and developing tours to "new" remote temple sites which had been largely untouched for centuries.
Now, since 2017, Dave is Based in his old home in Southampton, but still travelling around Asia and Europe.
HOME - TOURS - CAMBODIA - LAOS - INDIA - MALAYSIA - MYANMAR - THAILAND - VIETNAM


We have been working hard to establish a new reputation system for our community. We are doing this because we recognize that our community works hard, creates wonderful design and writing work, helps one another, learns from one another, and contributes energy, time, and creativity to projects on the site.
The reputation system is made up of several components, and will use a special, secret sauce to give all of our users a way to understand their relative strength in the community, and to encourage participation, promote quality, nurture community, discourage negative behavior, build loyalty to one another, and to facilitate member search and matching. The cS Award is part of this because we want to use it to encourage our community in all of these ways.
Having said all that, the October cS Award of $1,000 will be given to a creative who has been continuously active on the site for the longest period of time and who participates at a high level, contributes to the community, submits quality entries, and engages in behavior our community can be proud of. Now, we realize that there are many of you who have been around for a long time, so the tie-breaker will be for activity in the month of October. If you know of a cS Creative who you believe is deserving, please leave a shout-out on our Facebook page and share with others. We are celebrating loyalty, quality, and community, so please share with us!
If you're not already a fan of our Facebook page, you just need to click the LIKE button on crowdSPRING's Facebook page to be eligible to post. Good luck to everyone!
We are thrilled to announce that the September $1,000 cS award will go to jasonleow!
Jason shared many interesting resources and ideas on crowdSPRING's Facebook fan page during the month of September, and always took the time to explain why he was sharing each post. Just as important, Jason also took the time to comment on posts by others – something we love to see.
Jason has been a crowdSPRING member since February of this year and is from Singapore. We are proud to have him in our community.
Thanks to everyone who participated in September, and congratulations to jasonleow on winning the cS Award!


Set of 25 White Pearl Flourish Cupcake Favor Boxes - Favor Containers: Bags, Boxes, Jars and More!
A great way to send something sweet home with your guests. White cupcake boxes with pearl flourish design and clear, acetate window on lid. 3" x 3" x 3".
Contents not included. Package of 24.


text:
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"dojox/form/nls/cs/PasswordValidator", //begin v1.x content
({
        nomatchMessage: "Hesla se neshodují.",
		badPasswordMessage: "Neplatné heslo."
})
//end v1.x content
);

redpajama_set_name: RedPajamaGithub


November was crazy. Filled with SO much delicious food & drink, and 3 weekends away (yes, I was only in London one weekend throughout the whole of November… a bit mental!). This month's roundup does include a one more addition to the usual five (I struggled so much to narrow it down), including one or two finds from my trips. Loosen your belts, here are my top picks.
I think this is such a cute brand, and the flavours that are available is unlike anything I've seen. From Cheese to Salted Caramel, Berrylicious and Butterly Nuts, there's some unusual, yet fun, popcorn flavours.
The flavours from Popcorn Shed are fab. Some are a little more subtle than others, but all went down really well. My fave obviously had to be the butterly nuts – I just can't resist a peanut butter option!
The little packs (£18 for a snack pack bundle of 7) are the perfect size for having with lunch, or a little snack during a Netflix session. The larger boxes (£3.50) would make a cute accompaniment to any gift this Christmas – for those Christmas movie moments!
Rock Rose Gin is a multi-award winning handcrafted Scottish gin from Dunnet Bay Distillers. It gets its name from its primary botanical – the rhodiola rosea, or the rose in the rocks. This was the first botanical forage for Dunnet Bay Distillers, along the cliffs of the Pentland Firth. About a thousand years ago, vikings would go in search of Rhodiola rosea, which was thought to give them extra strength to continue on their long journey. Along with this traditional botanical, Rock Rose uses a blend of local and traditional botanicals to create a unique gin from the Highlands of Scotland.
The rose edge is super subtle, and the juniper does over power it a little, but it is one delicious gin. Fab with a slice of lemon to add a soft citrus touch, and fever tree tonic. I'm a HUGE gin fan, and this sure is up there with my faves.
I've been to this sweet little coffee house once before, with some old housemates. It's right on the roundabout by Highbury & Islington station, so a great location. I do love that area.
Inside Maison D'etre is small, but they have a little area, like a conservatory through the back. It's a cosy little spot. The menu is concise, but there's enough to choose from for such a small spot. The Bircher Muesli is a must- so fresh, creamy and flavoursome! It is £7, which is a little more than I'd usually pay for a cold brekkie, but it's worth it! Coffee is fab too – rich and smooth – and pretty standard in price. Fab little spot for a catch-up!
Ok, I know this means gin is on my list twice. But honestly, this was SO GOOD. A cute little garden popup near Broadgate Circle, so much greenery, cosy seats with blankets, an ice sculpture and delicious cocktails. What more do you need?
It was my first mulled gin, and it was seriously delicious! I'm definitely doing this myself at home. We might have left a little tipsy, after a chilled few under the tent. I'm hoping they bring it back sometime. I'd definitely pop down again for a drink or two!
I had a Winter Squash, cavalo nero, harissa yoghurt and eggs, and it was seriously dreamy. Never would have thought to have squash for breakfast before! The harissa added depth to the fresh ingredients, and everything together was just super delicious. The shakshuka was another big hit. It was rich, flavoursome and massive. The hash was superb too!
This was my favourite breakfast of the two spots we tried. With breakfast dishes priced between £4.50 and £7.50, it was really reasonable in price too. If you're up in Edinburgh anytime soon I do recommend adding this to your list! My full post on Edinburgh is coming soon!
When it's cold and miserable, a warming, comforting lunch is a must. Am I right, or am I right? Something freshly made, healthy and delicious. Because I need to feel at least a little good alongside all the treats throughout December! We tried the Hot Buddha Bowls at Beany Green recently – lemon and herb chicken, meatballs with tomato, or vegan Beany balls, served with roasted sweet potato, chickpea ragu, roasted aubergine, greens, mixed grain rice and fermented jalapeño hot sauce.
Served hot (well just more than warm), it was a fantastic mix of flavours and textures. The jalapeno sauce adds a warming little kick, and I'm a big fan of the chickpea ragu. The chicken was flavoursome, although not as tender as I'd have liked. But the meatballs were a winner – tasty, tender and saucy. At £7.90 to takeaway, it's a little on the pricier end for lunch for me, but on a day when im craving all the veg (or a hangover day) it's well worth it!
There you have it. November's top picks. Already excited for what December has to offer – bring on the festive food! Next month's round-up is going to be all my fave Christmas finds.
What have you tried this month?
*This post does include food/drink from events I've been invited to, or samples I've received. All views my own.
Wakey Wakey, Rise and Shine!


Bournemouth has become one of the most popular destinations for a Royal Stag Weekend, as it has more bars per square metre than London. A young population that just loves to party and miles of sandy beaches to enjoy, has created a city that has more activities than you can possibly enjoy in just one weekend. Bournemouth is a city that was created by the Gods of Stag and is made to ensure only the finest in stag events. Come and play and let this city just blow your mind.
DescriptionWant to enjoy a great weekend out with your lads but dont want to blow your budget? Then select this option and your gauranteed a Royal Stag Weekend to remember. We have taken care of all the details and all you need to do is turn up and have an amazing time!
DescriptionEnjoy a great night out with the lads! This package takes care of the laughter, booze and babes. Comedy Night will surely leave you laughing till your stomach hurts.
DescriptionThis action packed package will get you and your mates pumped up for a great weekend away. Nothing like modern simulated battlefield action and a little ancient bow and arrows. Want to know more select this option and find out.


The youth have been asked to take advantage of the government's free senior high school (SHS) policy to make their lives meaningful to the society.
Nana Anyimadu Brempong II, the Krontihene of Adjena, said they should make optimal use of the opportunity by working hard on their books.
That, he indicated, was the way forward, to justify the huge investment and strengthen the nation's human capital resource base for accelerated socio-economic development.
He made the call at the celebration of the Akwasidae festival held in his Adjena Palace.
Nana Brempong advised parents, particularly, those in communities along the Volta Lake, to make sure that all children of school going age, enrolled.
They should not be trafficked – sold into slavery, he said, adding that, the children belonged to the classroom.
He used the occasion to appeal to the government to build a new girls' dormitory and a library for the Adjena SHS.
He also invited citizens, living outside the area to identify with efforts at bringing development - making things better for their relatives back home.


text:
Q: System.ArgumentException: A matching constructor for the given arguments was not found on the mocked type I am Performing Unit Testing using Moq and I am facing this error :

System.ArgumentException: A matching constructor for the given arguments was not found on the mocked type.
---> System.MissingMethodException: Method not found: 'System.Reflection.Emit.AssemblyBuilder System.AppDomain.DefineDynamicAssembly(System.Reflection.AssemblyName, System.Reflection.Emit.AssemblyBuilderAccess)'.
at Castle.DynamicProxy.ModuleScope.CreateModule(Boolean signStrongName)

I'm new in this I don't understand what is the error. So, please can anyone please tell what I am doing wrong.
UniTest1.cs
public class EventUnitTests
{
    private readonly EventAppService _sut;
    private readonly Mock<IEventRepository> _eventMock = new Mock<IEventRepository>();
    private readonly Mock<IUserEventRepository> _userEventMock = new Mock<IUserEventRepository>();
    private readonly Mock<IUserRepository> _userMock = new Mock<IUserRepository>();
    private readonly Mock<ILogger> _logger = new Mock<ILogger>();
    private readonly Mock<IMapper> _mapper = new Mock<IMapper>();
    private readonly Mock<IEventUnitOfWork> _eventUnitOfWork = new Mock<IEventUnitOfWork>();
    private readonly Mock<IExceptionManager> _exceptionManager = new Mock<IExceptionManager>();

    public EventUnitTests()
    {
        _sut = new EventAppService(_eventUnitOfWork.Object, _userEventMock.Object, _userMock.Object, _eventMock.Object, _mapper.Object, _exceptionManager.Object);
    }
    [Fact]
    public async void GetEventDetailById()
    {
        var events = new Event { Id = 1, Title = "Three mistakes of my life", Date = DateTime.Now, Location = "Plot 13", Duration = 3, StartTime = DateTime.Now, Description = " A GOOD BOOK 1", OtherDetails = null, Type = EventType.PRIVATE, InviteByEmail = "nitin6283saini@gmail.com" };
        _eventMock.Setup(p => p.GetById(1)).Returns(events);

        _mapper.Setup(p => p.Map<Event, EventDTO>(events)).Returns(new EventDTO
        {
            Title = events.Title,
            Date = DateTime.Now,
            Location = events.Location,
            Duration = events.Duration,
            StartTime = events.StartTime,
            Description = events.Description,
            OtherDetails = events.OtherDetails,
            Type = events.Type,
            InviteByEmail = events.InviteByEmail
        });

        //EventAppService s = new EventAppService(_eventUnitOfWork.Object, _userEventMock.Object, _userMock.Object, _eventMock.Object, _mapper.Object, _exceptionManager.Object);
        OperationResult<EventDTO> result = _sut.GetEventById(1);
        Assert.Equal(result.Data.Id, events.Id);
        Assert.Equal(result.Data.Title, events.Title);
        Assert.Equal(result.Data.Location, events.Location);
    }

}

EventAppService.cs
public EventAppService(IEventUnitOfWork unitOfWork, IUserEventRepository userEventRepository, IUserRepository userRepository ,IEventRepository eventRepository, IMapper mapper, IExceptionManager exceptionManager) : base(unitOfWork, exceptionManager)
{
    this._mapper = mapper;
    this._eventRepository = eventRepository;
    this._userRepository = userRepository;
    this._usereventRepository = userEventRepository;
}

redpajama_set_name: RedPajamaStackExchange


Donahue Ridge, a smaller subdivision on the northern side Auburn offers affordable Auburn homes with many upgraded amenities on wooded lots. Newer spacious craftsmen's built homes with a variety of floor plan options are moderately priced in the upper $100s to the lower $200s. Donahue Ridge seems to have it all including spacious 3, 4, and 5 bedroom homes on spacious wooded lots. High demand features like granite countertops, wood flooring, tile in the wet areas, and rock accent exteriors are all available.
About the Current Builder: Grayhawk Homes offer you more value and choice! Our recently updated design center showcases our many decorator options and is staffed with a professional interior decorator to assist with selections. Two-time Homebuilder of the Year, Grayhawk Homes stands behind its new homes with the 2-10 Quality Builders' Warranty program. We pride ourselves on outstanding customer satisfaction before, during and after the construction of your new home. Grayhawk Homes are also ENERGY STAR® qualified saving you money month after month long after your purchase.


In Malaysia, up to 800,000 people are living with psoriasis. It affects 2-3% of the population and is more common than you think.1 A widespread misconception is that psoriasis is just a skin disease because it often presents itself with red, itchy, and flaky skin.
In fact, psoriasis is not just an external disease but an internal one.
As a result, your skin becomes flaky, red, and inflamed. Since your immune system affects your whole body, psoriasis can manifest itself on different parts of your body simultaneously (although it typically affects the surface of the elbows, knees, or scalp)4.
For some patients, psoriasis is not just cosmetic — living day-to-day with this disease can affect their overall quality of life. It goes beyond physical appearances and often manifests itself through self-defeating thoughts.
The biggest fear most people have when they first encounter this disease, is that psoriasis is contagious. Every psoriasis patient suffers differently. It takes a team to help overcome these barriers to living normal lives. Understanding this complex disease is key; read on to separate fact from fiction.
1. Psoriasis is not infectious.
While scientists know that the immune system and genetic factors plays a role in psoriasis development, something external might cause flare-ups as well.8 You can hug, kiss and have an intimate relationship with a person of psoriasis with no risk of directly contracting the disease yourself. It might run in families because some people can inherit the genes that make them prone to getting psoriasis but it doesn't transmit by close contact. It's okay to shake hands, breathe the same air, and share food with someone with psoriasis.
2. Psoriasis has a major health impact on your whole body.
Psoriasis is a lifelong auto-immune disorder that puts you at risk of developing inflammation of multiple systems in your body, including joints.
3. Not all psoriasis is the same.
There are several subcategories of psoriasis types. Knowing how to treat or manage psoriasis begins with figuring out the type of psoriasis you have and the severity with which symptoms present themselves.
Plaque psoriasis: The most common type; scaly plaques appear on your elbows and knees, but there are also variants that affect your scalp, lower back, or groin and armpit areas16. Plaque psoriasis causes raised, red patches covered with silvery, white scales. These patches may crack and bleed, they are often itchy and burn.
These subtypes of psoriasis are not exclusive, which means that a person with plaque psoriasis may develop pustular psoriasis or progress into erythrodermic psoriasis. Guttate psoriasis can be potentially cured but may progress into plaque psoriasis too.
Psoriasis triggers differ by individual on a case-by-case basis. You need to learn to recognize triggers particular to your case of psoriasis and track them in order to make positive lifestyle choices.
Make smart lifestyle choices while you're on psoriasis treatments. Give up smoking, and alcohol. Schedule daily relaxation periods and try to reduce your own stress levels. Exercise and be wary of medications and foods that may cause flare-ups.
5. There is no cure for psoriasis.
While there isn't a "cure" yet, psoriasis is very treatable. There are many ways to treat psoriasis, not just with topical creams. Treatment depends on the type of psoriasis you have, the severity, and the area affected.
When you see your dermatologist, you might be given topical creams, phototherapy, oral tablets or injections. It's important to set realistic treatment goals, and continuously monitor your progress. Individuals respond differently to treatments and may have to cycle through treatment options over time to see results.
Light therapy (using natural or artificial ultraviolet light) is the simplest and easiest form of treatment, used alone or in combination with other medications.
Chronic diseases such as psoriasis require you to be a proactive agent in your own healthcare and a strong advocate for your own well-being. Now that you're better informed, you have a starting point from which to manage your psoriasis triggers, learn about treatment plans, seek support, and make lifestyle choices.
Track your progress keenly so that you can have an open conversation with your doctor to get the best treatment for your skin. Before treatment, list down your symptoms, medications or dietary supplements you're taking, and treatments you're interested in.
During treatment, be patient, stay compliant to doctor's orders, and give it about 8-12 weeks before expecting results. Always stay in touch with your doctor and do not give up.
3 Krueger G. Arch Dermatol 2001; 137:280-84.


text:
Their Fathers' Foundations
Long before they met, Susan and Tom Gus listened — and were shaped — by their fathers' advice.
For Susan, it was the importance of education. For Tom, it was the value of work. The lessons played key roles for both while their mothers dealt with chronic illnesses.
A Dairy Dream
Susan grew up in rural Wisconsin on a dairy farm and attended a one-room schoolhouse.
Understanding the value of education, Susan's dad insisted that she go to college to receive the education neither he nor Susan's mom had.
"Back then there weren't a lot of options, so he asked, 'Do you want to be a nurse, a secretary or a teacher?'" she says. After one year of classes in high school to prepare for a nursing career, Susan determined nursing wasn't for her.
Susan's family moved to Arizona in hopes that a drier climate would help alleviate her mom's arthritis symptoms. While there, she discovered a love of working with children, enrolled in college and became an elementary school teacher. "We were poor growing up, but I had everything I needed," Susan says. "In fact, I didn't know until I applied for college that we were in the poverty level."
Tom was raised on a farm about 25 miles east of Los Angeles.
"It was a little unique to have this type of land so close to Los Angeles. We had horses, goats, chickens, and ducks and stuff," Tom says. "But I considered myself a big-city boy."
Raised primarily by his father due to his mother's multiple sclerosis, Tom relished his bond with his father.
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Rising in Arizona
To meet the increasing demand to treat patients with serious and complex health conditions in the growing Southwest, Mayo Clinic is embarking on a capital expansion that will nearly double the size of its Phoenix campus over the next five years.
The highlights of the expansion include an additional 94 inpatient beds; a new six-story patient tower; a three-floor addition to the existing four-story Mayo Clinic Building; and a new three-story building to house expanded emergency and laboratory departments, as well as two new parking structures. This capital expansion project will bring the Arizona campus forward by investing in people, space and innovation, while setting Mayo Clinic on a trajectory as the premier destination medical center in the Southwest.
Uncle Sam's Call
Tom always knew he wanted to be a veterinarian. Because of this, he thought time was on his side. After high school he and a friend traveled around the country before starting junior college and eventually university. But Tom also had a birth date that was high in the draft order, and the Army selected it.
"The Army was a life-changing event for me. I spent most of my time in Vietnam," he says. "Before I was in the service, I was going to school, but I wasn't really setting any records.
"After being in the service and kind of experiencing life and the rawness of it all, I came out with a new quest and a new sincerity in my efforts to go to school and achieve."
When Tom returned, he excelled and was accepted into veterinary school, earning a doctorate in veterinary medicine. He used his GI benefits and his savings from working to graduate nearly debt-free. He moved to Arizona in 1980 for work as a veterinarian, and in 1986, following his dad's wisdom to take risks, he bought the veterinary practice.
An Arizona Match
Susan and Tom met, married and adopted three children. Now retired, the couple has decided they want to give back to organizations they feel can do the most good.
Honored by Mayo Clinic as Principal Benefactors, the Guses' belief in Mayo led them to support priorities such as Mayo Clinic School of Medicine and capital expansion.
The Guses point back to their fathers' guiding voices as lessons they now hand down to their children. ■
Philanthropy fuels the mission of Mayo Clinic. Visionary benefactors are the vital catalysts behind our pioneering patient care, breakthrough medical research and world-class educational programs.
We are solving the world's most serious and complex medical challenges – one patient at a time. Support Mayo Clinic's efforts today.
Arizona Arthritis Multiple sclerosis Stories of Hope


At Hull Trains we are dedicated to providing you with the best possible rail service. Our commitment to our customers is our main priority.
Our priorities of your experience are summarised into three key areas: My journey, My ticket and My future travel.
The standard measure used throughout the rail industry in Great Britain is the Public Performance Measure (PPM). This is a combined measure of how many trains timetabled to operate have run throughout the entire route and calling points and how many have arrived at their final destination within ten minutes of their advertised time. The results of this measure are reported every four weeks.
Our last 4 period performance results are shown in the table below.
To download our 13 Period Performance History please click here.
You can check if your journey is delayed using our Live departures & Arrivals or check for any future planned timetable changes that may affect your travel. Network Rail also have a Delays explained section on their website where you can find out more about the common causes of delays - and what we're doing to reduce their frequency and impact.
Along with our industry colleagues we have conducted research about how you, our customers feel, when services are disrupted. We are planning to use this to guide our strategy and processes over the coming months so we can improve the way we talk to you during disruption. The national research is available here.
Our National Rail Passenger Survey overall satisfaction score for Autumn 2018 was 91%.
The number of complaints we received in 2017-18 on average 12 per 1000 customer journeys.
Information about stations that we call at, including ticket office opening hours and the facilities available, can be found in our Stations section.
You can see how Network Rail's planned track improvement work may affect your journey in our Engineering works section.


Porsche LMP1 team principal Andreas Seidl struggles to verbalise the dramatic turn of events that led to a 19th Le Mans victory on Sunday.
Porsche LMP1 team principal Andreas Seidl says it is "hard to find words" to describe the German manufacturer's record-extending 19th overall victory in the 24 Hours of Le Mans on Sunday.
The #2 Porsche 919 Hybrid shared by Brendon Hartley, Earl Bamber and Timo Bernhard fought back from a front axle issue that left it 18 laps down and 55th overall to take victory at Le Mans, weathering a race of attrition that saw all six LMP1 cars hit technical trouble.
Porsche's #1 car had looked set for victory, running 13 laps clear of the field before suffering a terminal failure in the 21st hour.
This allowed Jackie Chan DC Racing's #38 Oreca 07 Gibson to take over in P1 and become the first LMP2 car to ever lead overall at Le Mans, with the #2 Porsche's fightback ultimately preventing a shock result.
"It's hard to find words for what happened," Seidl said, reflecting on Porsche's victory. "The drivers and the entire team have done an amazing job. We can put two tough weeks behind us that provided some highs and lows but we fought with typical Porsche spirit.
"It will take some time for what we have achieved today to sink in. We've now won Le Mans three times in a row which is just sensational. The team worked relentlessly for this over the past 12 months. Toyota was a very strong competitor. They pushed us to the limits and beyond and we both paid the price.
"It is sad that Neel Jani, Andre Lotterer and Nick Tandy [in the #1 Porsche] retired from the race because they controlled it for a long time. But Earl Bamber, Brendon Hartley and especially Timo Bernhard deserved to take the race win. Timo was the development driver right from the beginning of the programme.
"After the long repairs, the three of them kept fighting and were ultimately rewarded."


text:
Sugababes, The Feeling and Gnarls Barkley For Secret Fest
. The following story was part of the Day in Rock Report for 5/14/08 - (PR) This year sees Vodafone Live Music come back with a bang as it kicks off this summer's music calendar with the first TBA gig in Edinburgh on June 1.
Taking the city by storm will be the Sugababes, The Feeling and Gnarls Barkley. For 2008 the TBA format has evolved; rather than small, secret venue gigs with just one artist, Vodafone TBA 2008 will reveal the location and line up for the multi artist mini "festival" in advance.
The Sugababes need little introduction. With more than five million albums sold (including 3 triple-platinum discs in the UK) and thirteen Top 10 singles notched up to date, Keisha, Heidi and Amelle guarantee that this is one performance not to be missed.
Joining the girls will be The Feeling a band who have firmly cemented themselves on the live music scene. With a number one album under their belt, sales of over a million for their debut album 'Twelve Stops And Home' and more than 200 shows behind them, they promise to deliver a true rock- out on the day.
Completing the line up is the phenomenal Grammy-winning duo Gnarls Barkley, famous for their inventive, elaborate live performances. Having made history when their phenomenal single 'Crazy' became the first single to top the charts on download sales alone as well as becoming the longest running #1 single for over a decade, Gnarls Barkley returned in 2008 with their highly acclaimed album 'The Odd Couple'.
Vodafone customers will have the opportunity to win tickets to this incredibly special event for themselves and two friends by texting ACTS to 61500 from the 5th May. Those not lucky enough to attend will be able to watch the gig from 1pm on T4 on June 1.
The second Vodafone TBA is planned for August and will lead up to the Vodafone Live Music Awards in the Autumn. Now firmly established on the music industry's calendar, the Vodafone Live Music Awards celebrate all that is good and great about the UK's booming live music scene. Fans will soon have the chance to vote for the favourite bands at www.vodafone.co.uk/music to be put forward to the judging panel in May. Previous winners have included Iggy Pop, Take That, Razorlight, Amy Winehouse and Mika.
Preview and Purchase Sugababes CDs
Sugababes MP3 Downloads
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antiMUSIC News featured on RockNews.info and Yahoo News .


text:
Die flambierte Frau é um filme de drama alemão de 1983 dirigido e escrito por Robert van Ackeren e Catharina Zwerenz. Foi selecionado como representante da Alemanha Ocidental à edição do Oscar 1984, organizada pela Academia de Artes e Ciências Cinematográficas.

Sinopse
Eva é uma dona de casa da classe alta que decide deixar o marido arrogante para trás e começar uma nova vida como acompanhante. Com a ajuda de Yvonne, uma garota de programa, ela aprende o básico sobre sua nova profissão. Eva começa a ter um caso com Chris e pouco tempo depois descobre que ele também é garoto de programa. Então, ela passa a morar na casa de Chris, que é grande o suficiente para que ambos possam oferecer seus serviços separadamente.

Aos poucos, Eva vai descobrindo o mundo do sadomasoquismo e se vê cada vez mais apaixonada em ser uma dominatrix. Chris vê que Eva está conseguindo muito dinheiro com esse ramo da dominação e começa a sentir ciúmes. A partir daí, a tensão no relacionamento dos dois se resume a conflitos causados pelos instintos possessivos de Chris.

Elenco
 Gudrun Landgrebe como Eva, uma dona de casa de classe alta que larga tudo para trabalhar como acompanhante/dominatrix.
 Mathieu Carrière como Chris, gigolô com quem Eva acaba tendo um relacionamento.
 Hanns Zischler como Kurt, melhor amigo de Chris.
 Gabriele Lafari como Yvonne/Karin, garota de programa que ajuda Eva na nova profissão.

Filmes em língua alemã
Filmes da Alemanha Ocidental
Filmes da Alemanha de 1983
Filmes sobre BDSM

redpajama_set_name: RedPajamaWikipedia


text:
Beniamin (in armeno Բենիամին )  è un comune di 745 abitanti (2010) della Provincia di Shirak in Armenia.

Altri progetti

Comuni del Shirak


text:
This article is more than 16 years old
George, God here ...
President Bush has words with the Almighty
"George?"
"This is God here ..."
"Hi, God. What can I do for you?"
"I want you to stop this Iraq thing, George."
"But you told me to do it, God!"
"No I didn't, George ..."
"But you did! You spoke to me through Karl, Rumsey and Dick and all those other really clever guys!"
"How did you know it was me talking, George?"
"Instinct, God. I just knew it!"
"Do you really think I'd want you to unleash all this horror and bloodshed on another lot of human beings?"
"But they're Muslims! They don't believe in You, God!"
"But, George, they do believe in me. Jews, Christians and Moslems all worship the same Me! Didn't you do comparative theology at school, George?"
"No, of course not! You think I'm some sort of peace-waving dope-headed liberal faggot-lover, God?"
"No, of course not, George, but I expect you to know something about the people you're bombing."
"Oh, come on! I know it's right to bomb those oily rag-heads until there's not one left to wipe a wrench on!"
"How do you know that, George?"
"Cause You tell me that's what I should do, God."
"George, I do not tell you to do that!"
"But I hear You, God! You speak to me! You tell me what to do! You tell me what is Right and what is Wrong! That's why I don't need to listen to any soft-baked, mealy-mouthed liberal Kerry-pickers!"
"George, you're deluding yourself."
"God! How can you say that? I got some of the most powerful people on this planet down on their knees every day in the White House just a-praying to You! Now are you gonna tell me You ain't listening? Because if You ain't listening, God, that's Your problem - not mine!"
"George, of course I'm listening - it's you who is not listening to Me!"
"And I'll tell you why! 'Cause You ain't addressing me right."
"What d'you mean, you jumped-up little Ivy League draft-dodger?"
"If you're so 'omniscient', God, you oughta know that you gotta go through Karl Rove, John Ashcroft, Rumsey and Dick ... those fellas know what they're talking about! I can't listen to just any deity who can pick up the phone!"
"But, I'm God, George!"
"Does Karl say you are?"
"But why do you believe Karl?"
"Because my gut tells me he's right!"
"Listen, you ignorant little pinch-eyed Billy Graham convert! Can't you get it into your head that I'm God and I'm telling you to stop all this 'pre-emptive strike' nonsense! Stop destroying Iraq! Stop supporting that monster Sharon! Stop picking a fight with the only other human beings on the planet that believe in Me! You're leading the world into unbelievable chaos and horror!"
"That's enough, God! That's just the sort of defeatist crap that I won't allow in the White House! Get out of here!"
"I cannot believe I'm hearing this, George."
"Well you better start believing, God, because this is the new reality. Don'tcha know that a recent Gallup poll shows that 42% of Americans identify themselves as 'born again'? That cuts across Republicans and Democrats, rich and poor, white and black! This is a real political power base, God, and you'd better believe it!"
"Look, all I'm asking is for you to show a little compassion to your fellow human beings!"
"I'm not going to debate this with you, God! You're beginning to sound like you belong to the reality-based community!"
"What the hell does that mean?"
"Well by the 'reality-based community', we mean people who believe that solutions emerge from their judicious study of discernible reality." "Sounds fair enough..."
"But, as one of my advisors told Ron Suskind of the Wall Street Journal: 'The reality-based community is not the way the world really works any more. We're an empire now and, when we act, we create our own reality. And while you're studying that reality - judiciously, as you will - we'll act again, creating other new realities, which you can study too, and that's how things will sort out. We're history's actors . . . and you, all of you, will be left to just study what we do'."
"You mean...you don't give a damn, George?"
"I mean You speak through me, God, not the other way round! Is that clear?"
"Yes, Mr President."


text:
// Copyright 2014 The Bazel Authors. All rights reserved.
//
// Licensed under the Apache License, Version 2.0 (the "License");
// you may not use this file except in compliance with the License.
// You may obtain a copy of the License at
//
//    http://www.apache.org/licenses/LICENSE-2.0
//
// Unless required by applicable law or agreed to in writing, software
// distributed under the License is distributed on an "AS IS" BASIS,
// WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
// See the License for the specific language governing permissions and
// limitations under the License.

package com.google.devtools.build.lib.analysis;

import com.google.common.base.Objects;
import com.google.common.base.Verify;
import com.google.common.collect.ImmutableList;
import com.google.devtools.build.lib.analysis.config.BuildConfiguration;
import com.google.devtools.build.lib.analysis.configuredtargets.RuleConfiguredTarget;
import com.google.devtools.build.lib.cmdline.Label;
import com.google.devtools.build.lib.collect.nestedset.NestedSet;
import com.google.devtools.build.lib.packages.PackageSpecification;
import com.google.devtools.build.lib.packages.Target;
import java.util.List;
import javax.annotation.Nullable;

/**
 * A helper class for building {@link ConfiguredTarget} instances, in particular for non-rule ones.
 * For {@link RuleConfiguredTarget} instances, use {@link RuleContext} instead,
 * which is a subclass of this class.
 *
 *
The class is intended to be sub-classed by RuleContext, in order to share the code. However,
 * it's not intended for sub-classing beyond that, and the constructor is intentionally package
 * private to enforce that.
 */
public class TargetContext {

  private final AnalysisEnvironment env;
  private final Target target;
  private final BuildConfiguration configuration;
  /**
   * This list only contains prerequisites that are not declared in rule attributes, with the
   * exception of visibility (i.e., visibility is represented here, even though it is a rule
   * attribute in case of a rule). Rule attributes are handled by the {@link RuleContext} subclass.
   */
  private final List<ConfiguredTarget> directPrerequisites;
  private final NestedSet<PackageSpecification> visibility;

  /**
   * The constructor is intentionally package private.
   *
   *
directPrerequisites is expected to be ordered.
   */
  TargetContext(AnalysisEnvironment env, Target target, BuildConfiguration configuration,
      Iterable<ConfiguredTarget> directPrerequisites,
      NestedSet<PackageSpecification> visibility) {
    this.env = env;
    this.target = target;
    this.configuration = configuration;
    this.directPrerequisites = ImmutableList.<ConfiguredTarget>copyOf(directPrerequisites);
    this.visibility = visibility;
  }

  public AnalysisEnvironment getAnalysisEnvironment() {
    return env;
  }

  public Target getTarget() {
    return target;
  }

  public Label getLabel() {
    return target.getLabel();
  }

  /**
   * Returns the configuration for this target. This may return null if the target is supposed to be
   * configuration-independent (like an input file, or a visibility rule). However, this is
   * guaranteed to be non-null for rules and for output files.
   */
  @Nullable
  public BuildConfiguration getConfiguration() {
    return configuration;
  }

  public NestedSet<PackageSpecification> getVisibility() {
    return visibility;
  }

  /**
   * Returns the prerequisite with the given label and configuration. Throws a RuntimeException if
   * no such prerequisite exists.
   */
  TransitiveInfoCollection findDirectPrerequisite(Label label, BuildConfiguration config) {
    return Verify.verifyNotNull(maybeFindDirectPrerequisite(label, config),
        "Could not find prerequisite %s in the expected configuration", label);
  }

  /**
   * Returns the prerequisite with the given label and configuration, or null if no such
   * prerequisite exists.
   */
  public TransitiveInfoCollection maybeFindDirectPrerequisite(Label label,
      BuildConfiguration config) {
    for (ConfiguredTarget prerequisite : directPrerequisites) {
      if (prerequisite.getLabel().equals(label)
          && (Objects.equal(prerequisite.getConfiguration(), config))) {
        return prerequisite;
      }
    }
    return null;
  }
}