When it comes to choosing friends, we tend to be quite picky because we want friends that are loyal to us.
In the West of London is where you will find Notting Hill. Made famous by Hugh Grant and Julia Roberts in the 1999 British Romcom. It is an expensive part of London and although not really a tourist area is definitely worth a visit especially in the summer.


Summary: With $300 million on the line, distant relatives are coming forward to prove their relationship to the late Prince.
The battle of the late singer, songwriter, and overall music prodigy money is just beginning. RadarOnline.com reports that the mother of Prince's supposed grandniece has stepped forward to claim her share of the $300 million estate.
Wisconsin lawyer Michael B. Padden presented an official letter to the presiding Minnesota judge on the case. Padden wanted the minor to be included in the proceedings but the child's mother had not come forward so he wanted the court to appoint her a guardian.
See Prince's Sister Claims Late Singer Did Not Leave a Will.
The girl's mother, Jeannine Halloran, has since come forward to file an "Affidavit of Heirship" and birth certificates to prove their family relation. The child's father, Duane Joseph Nelson Jr., and grandfather, Duane Joseph Nelson Sr. are deceased. It is claimed that Senior is Prince's half-brother.
Read Kansas City Man Claims To Be Prince's Long Lost Son to learn more.
Nelson Sr.'s daughter has also filed paperwork to be part of the proceedings dividing his estate. Brianna Nelson claims to be Prince's niece. A number of other people have also stepped forward since Prince's sudden death just weeks ago. Prince did not have a will, leaving his alleged heirs to battle it out in a Minnesota court for their share of his Paisley Park estate.
Do you think more distance relatives of Prince will step forward? Tell us in the comments below.
To learn more about Prince, read Music Legend Prince Dead, Leaves Behind Legal Legacy.


text:
President Infinity
A New Spirit - 1980
By Lahbas,
February 15, 2014 in President Infinity
Lahbas 4
Lahbas
Location:Massachusetts
Interests:Various.
This is the first in a series of scenarios I intend to release, going from 1980 to around 2008; I may or may not get there, depends on the time I have available.
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
The divergence for "A New Spirit" is that Jerry Brown enters the Democratic Primaries much earlier than he historically did, and so it is he rather than James Carter that ends up winning the Democratic Party nomination, and subsequently the general election against incumbent President Gerald Ford. Despite a new sense of optimism that Brown brings with him into Washington, the feeling is quickly depressed by the economy taking a turn for the worse, being further deepened by an energy crisis precipitated by the fall of the Iranian government to Islamists in September of '78. Legislation in favor of clean energy sources was shortly after pushed through Congress up until the Republican Party took up the majority in the House and Senate in January, and though funding is no longer to the levels as proposed by President Brown oil prices are coming down, with the initiatives winning the approval of the majority of Americans. Inflation remains a major concern however.
While the rise of the Islamic Republic in Iran was a notable political issue of the time, it was dwarfed in comparison with the movement of Soviet military forces into Afghanistan in June of '79. Publicly the Soviet Union justified their intervention in that it was meant to help the government lead by Nur Muhammad Taraki put down the insurgency that had developed against him. To most international observers however this was seen as nothing more than the propping up of a puppet government, and to those like Senator Henry "Scoop" Jackson it was nothing less than the first stage of a Soviet attempt to expand their influence further into the Middle East and the Indian subcontinent. The Brown administration bitterly condemned the intervention and formally lodged a complaint to the United Nations, but quickly found itself divided on how to respond beyond that. Secretary of State Cyrus Vance had worked with Brown to create some weak yet significant economic ties with the Soviet Union which would be undone by any suggested economic sanctions, additionally also jeopardizing the proposed SALT III talks. Zbigniew Brzezinski on the other hand was in favor of cooperating with multiple nations in arming the Mujahedeen who were fighting the Soviets and for severe economic sanctions until the Soviet Union withdrew from the country. Brown would as he often did eventually side with Vance, leading to Brzezinski's resignation in September.
Brown's governance has not been a fiscally liberal one, and on the issue of balancing the budget he had found more success in working the Republican Congress rather than the Democratic one. Cuts to social programs, especially in combination with a significant rise in the budget of the National Aeronautics and Space Administration (which was also given a Cabinet Post), has earned him the animus of the Party's liberals, among them Senator Edward Kennedy and Representative Ron Dellums. Open pressure upon state legislatures to adopt the Equal Rights Amendment nor general Social Liberalism has moved this sentiment.
As the middle of October rolls around, Brown is in a rather weak state politically. Washington Senator Henry Jackson has declared that he would run against him and is but a few steps behind the President in the polls. Representative Ron Dellums, after strongly considering running as a third party candidate in the general election, has decided to challenge Brown directly also. A number of Republican candidates have also come to the fore, among them former Governor of Texas John Connally, Senate Majority Leader Howard Baker, George H. W. Bush, Governor Pierre du Pont, CEO Frank Borman, Senator Robert Dole, and others.
Among third parties, the American Party has managed to recruit Representative Larry McDonald of Georgia who is polling decently in the South and West.
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
I'd post some pictures, but for some reason the forum isn't letting me do that (something about me not having permission to do so).
It's still in the alpha stages, but it will be chock full of various easter eggs pointing to the changes that have occured following the divergence. Anyway, in light of nothing more to give you, I'll end with a list of added, planned, and planned off candidates.
President Edmund "Jerry" Brown - Added
Senator Henry "Scoop" Jackson - Added
Representative Ronald "Ron" Dellums - Added
Senator Edward "Ted" Kennedy - Added (Off)
Former Governor Cliff Finch - Planned
Former Governor Hugh Carey - Planned (Off)
Senator William Proxmire - Planned (Off)
Senator George McGovern - Planned (Off)
Former Representative George Bush - Added
Former Governor John Connally - Added
Senate Majority Leader Howard Baker - Added
Former President Gerald Ford - Added (Off)
CEO Frank Borman - Planned
Representative Phil Crane - Added
Governor Pierre "Pete" du Pont - Planned
Senator Robert "Bob" Dole - Planned
Senator Lowell Weicker - Planned
Senator Chuck Percy - Planned (Off)
Former General Alexander Haig - Planned (Off)
Representative John Anderson - Planned (Off)
Representative Larry McDonald - Added
Attorney Ed Clark - Added
Pediatrician Benjamin Spock - Planned
Fixed the problem I was having, and so edited the post to reflect the scenario in full. All comments and suggestions are welcome. Hoping to get a testing version out by the first of March.
It looks reasonable so far. There may be some obscure fact about the end of the 70's in US politics I don't know, but what convinces Reagan not to run if Brown's the incumbant?
Its mentioned in one of the character bios, but I figure I should address this. Ronald Reagan ends up coming down with Pneumonia in the Fall of '78 while campaigning for congressional candidates with it eventually moving down to his lungs (something like this nearly happened in OTL but some months earlier). Sometime in December Reagan passes away, leaving the race for the Republican nomination wide open.
Jack Kemp was originally supposed to be the undisputed "heir" to the movement, but I decided to have him run for the Senate instead which would set him up nicely for a run in '84 or '88. Phil Crane and Frank Borman are possibilities to come on top, but Borman's politics remain a mystery to me, and Crane doesn't seem to have the same kind of pull as Reagan does. Du Pont is obviously a possibility, but he doesn't have much in the way of name recognition yet. May be best that the field is simply scattered.
I may also remove Anderson entirely as I want to put Chuck Percy in as an active contender, and the two would only serve to eat into the exact same base.
Also no longer decided on who the nominee for the Republican Party should be; I was initially set on Bush but now I'm leaning towards Baker, and when I set this out as a scenario for the 2008 version, John Connally was the nominee.
If you check, the official TheorySpark 1980 scenario for P4E2008 has the platforms for most of the candidates you're considering (except, notably, Borman, among a few others), at least for that scenario's issues. You've probably already checked it out, but just in case it can offer some inspiration on a second glance...
Edit: I realize, on a second reading of your post, that this post is not at all helpful.
I've expanded the number of Issues to twenty-five, not counting the character ones and issue familiarity. I also have access to the original 1980 scenario and am pulling some from there, but obviously not all of them are present. I'd like to add events as well, but those aren't yet in the campaign editor, and I don't trust myself to add them in manually.
Also I have to ask, a bit out of desperation unfortunately, does your local library or (if you are attending one) university has access to GallupBrain? I need access to the polls for this period in regards to the Republican candidates, and I'm having a lot of trouble finding them in book form (which themselves are at best spotty). I'm asking a number of persons I know, and so far no luck.
I could always check, though, I'm afraid, I live in Canada, so it's a bit of a stretch.
Another thing that came to mind is, was a biography or (even better) autobography ever written on Frank Borman? If you could find such a text, even in online form, it may elucidate his political views (then again, it may just praise his business accomplishments and charitable good works and dote on his childhood and family life, you never know).
Location:United States of America
Interests:Donald Trump, The Tea Party, Sarah Palin, GOP, Conservatives, Libertarians
This looks very promising! Now..I am me excited about this like..I get excited over a release on a game or a new game in a series lol.
Yeah, not sure if Gallup would extend to Canada. : /
I've found interviews and such with Frank Borman, but they never discuss politics, almost always being centered around his time with NASA and when he headed Eastern Airlines, in addition to some background bits. There are some articles that discuss Borman as a political candidate for an office (one Presidential, another I think as a Governor or Senator) but those are behind pay-walls. I'm trying to get access to those as well through my university library, but looking for backups just in case they prove to be rather bland regarding their information.
L1056 0
Pleb
If/When you get it up and running, i'd like to try it out. If you could send it to lb10234@gmail.com.

redpajama_set_name: RedPajamaCommonCrawl


text:
State of the City - Shane Horn - Adrian City Administrator
T he top administrator of the City of Adrian, Shane Horn, spoke to audience members today. He started with the City on 1992. Prior to becoming Administrator worked in the Utilities Department for 19 years and became its Director. Shane was appointed Administrator in November of 2013. He is married to his wife, Michelle (currently employed at Gleaners), and they have a son, Brad (a former Junior Rotarian) who is a sophomore at CMU, and a daughter who is a senior at AHS.
Shane began by thanking our club for its involvement in the community adding that is was very much appreciated. Some of the information he shared was: A new City budget year begins officially the end of this month. Projected revenues for the 2016-17 General Fund are $9.1 million with an equal amount in expenses. Fiscal year budget is expected to be $29.4 million. A 1.5% increase was approved to all employees; health care costs will increase by 7% (Priority Health replaced BC/BS who wanted a 36% increase over last year which was cost prohibitive); rates for sewer and water inceased 2% equating to about a$1,41 per month increase to the average user; $40,500 was appropriated for capital improvements next year (down from what started out amounting to $400,000+); a slight increase in real property values; and a reduction of 3 firefighters due to retirement and attrition (current staff at 15 fulltime). A FEMA grant several years ago did fund 3 firefighters which was not renewed.
Revenues for the City come from essentially 2 sources, Shane said, property taxes (55%) and state revenue sharing (23%) both of which have been drastically impacted the past 6 or 7 years resulting in a reduction in services. An additional 10% of revenue comes from the park system. Relative to expenses, publicity accounts for the largest chunk – account for a little over 50% of the general fund. Residential and commercial property values amount to $177.3 million. The average home price in the city is $72,000. In order to recover what the city has lost over the years, taking into account the rate of inflation, it will take the city until 2035 to get back to the revenues enjoyed in 2006-2007, Shane said.
The current charter millage levied by the city is 13.6293 mils. The Headlee Rollback was defeated in 2013 which would have increased the millage back to 15 mil level. Consequently, the city loses some $500k per year as a result. The commission approved a 1 mil levy for local street improvements and a millage for the former Adrian Public Library was levied for then new "District Library" which has a favorable impact on city finances. Staffing levels within municipal government nationwide is 16.4 employees per 1,000 population. In Michigan that average is 12.2/per 1,000. In Adrian, the figure is 5.6/per 1,000!
Projects that Shane highlighted include: Curbside spring pickup, the development of Chomp Burgers, several new Dollar General Stores have been built, Dunham's in the Adrian Mall, grants approved to combat blight ($325k), the new proposed Aubree's restaurant in front of the Adrian Mallthe exciting Strongback project in downtown Adrian and the new Gaslight Village.
Shane concluded his presentation by sharing with us various options the city was considering to generate additional revenue including a City Income Tax which, at this time, lacks commission support would generate approximately $4 million at which time the millage would be rolled back to 6.8 mils for city residents, Shane said. "A lot of momentum is going on" all over the city. Thanks, Shane, for a very interesting and comprehensive presentation.


text:
Gordon Barclay Corbet (* 4. März 1933 in Dundee, Schottland) ist ein schottischer Mammaloge.

Leben
Corbet ist der Sohn von George und Mary Corbet. Nach der Absolvierung der Morgan Academy in Dundee, studierte er zwischen September 1955 und August 1958 Zoologie am University College Dundee, am Queen's College und schließlich an der University of St Andrews, wo er 1960 er mit der Dissertation The distribution, variation and ecology of voles in the Scottish Highlands zum Ph.D. promoviert wurde. Von 1958 bis 1959 war er Assistenzdozent am Sir John Cass College in London. 1959 heiratete er Elizabeth Urquhart. Aus dieser Ehe gingen ein Sohn und eine Tochter hervor. Von 1960 bis 1971 war er leitender Wissenschaftler am Natural History Museum in London. Von 1971 bis 1976 war er stellvertretender Leiter der zoologischen Abteilung des Natural History Museum. Von Juni 1976 bis zu seinem Ruhestand im Jahr 1992 war er Leiter der zentralen Dienststelle des Natural History Museum.

Neben mehreren Büchern über die Säugetiere Großbritanniens veröffentlichte Corbet gemeinsam mit John Edwards Hill ein Werk über die Säugetiere der indomalayischen Region sowie eine Liste über die Säugetiere der Welt. Ferner beschrieb er vier Säugetiertaxa, darunter Choeropsis liberiensis heslopi (Unterart des Zwergflusspferds, die mittlerweile als ausgestorben gilt), Petrodromus tetradactylus zanzibaricus (Unterart der Rüsselratte), Rhynchocyon cirnei shirensis  (Unterart des Gefleckten Rüsselhündchens) sowie Paradoxurus hermaphroditus dongfangensis (eine Unterart des Fleckenmusangs).

Schriften (Auswahl)
 The Terrestrial Mammals of Western Europe, 1966
 The Identification of British Mammals, 1969
 Finding and Identifying Mammals in Britain, 1975
 A Review of the Family Canidae, with a Classification by Numerical Methods (mit Juliet Clutton-Brock und Michael Hills), 1976
 The Handbook of British Mammals, 2. Auflage (mit Henry Neville Southern), 1977, 3. Auflage (mit Stephen Harris), 1991
 The Mammals of the Palaearctic Region, 1978
 Town and Gardens (mit Dennis Owen, Franklyn und Margaret Perring, Paul Whalley, Frederick Wanless, Roger Lincoln und James Ferguson-Lees), 1978
 Collins Handguide to the Wild Animals of Britain and Europe (mit E. Nicholas Arnold und Denys Ovenden), 1979
 The Mammals of Britain and Europe, 1980 (deutsch: Pareys Buch der Säugetiere. Alle wildlebenden Säugetiere Europas, 1982, Übersetzung von Richard Kraft)
 The Family Erinaceidae: A Synthesis of Its Taxonomy, Phylogeny, Ecology and Zoogeography, 1988
 A World List of Mammalian Species (mit John Edwards Hill), 1. Auflage 1980, 2. Auflage 1986, 3. Auflage 1991
 The Mammals of the Indomalayan Region: A Systematic Review (mit John Edwards Hill), 1992
 The Nature of Fife, 1998

Literatur
Who's Who 2017, A & C Black, an imprint of Bloomsbury Publishing plc, 2017; online edn, Oxford University Press, 2016; online edn, Nov 2016 CORBET, Dr. Gordon Barclay, abgerufen am 25. Juli 2017.

Weblinks
Kurzbiografie bei der University of Dundee

Einzelnachweise

Mammaloge
Sachbuchautor (Zoologie)
Brite
Schotte
Geboren 1933
Mann

redpajama_set_name: RedPajamaWikipedia


text:
Zimbabwe health crisis deepens
OPERATIONS at Parirenyatwa and Harare Central hospitals yesterday ground to a halt after nurses joined the strike by doctors, with most wards at Zimbabwe's two largest referral hospitals closed, increasing pressure on President Emmerson Mnangagwa's administration.
Public hospital doctors have been on strike for over a month citing poor working conditions and remuneration and yesterday, nurses joined the job action citing overwork and "incapacitation", catching authorities by surprise.
Zimbabwe is dealing with its worst economic crisis in a decade with inflation nearing 300% in August and rolling power cuts that have decimated key industries.
The country is also dealing with a shortage of local cash and hard currency, fuel and basic goods such as bread.
Yesterday, several wards at the public health institutions were abandoned, while others had been closed in the absence of key personnel, crippling operations at the institutions that were already struggling with shortages of medicines.
In a dramatic move, nurses at Parirenyatwa started toyi-toying in the hospital corridors, leaving authorities dumbfounded.
Although the nurses signed up on the 60% increment offered by the State last week, they claimed that the prices of basic commodities had more than doubled, rendering the increase useless.
On Wednesday, State-owned power utility Zimbabwe Electricity and Transmission Distribution Company raised electricity tariffs by 320% from 38,61 cents to 162,16 cents.
In August, Finance minister Mthuli Ncube raised the cost of government services by 500% in his mid-term budget review.
Zimbabwe's health workers want their salaries indexed in United States dollars, a currency the government abandoned in February in favour of its local currency that has plummeted by 512% since.
"We cannot even afford bus fare to come to work. We beg for transport from good Samaritans, a situation which is humiliating," one nurse said.
A senior nurse, who was also part of the group, said they were overwhelmed since the doctors went on strike and that patients were dying because the nurses could only administer care within their limited scope.
"The doctors have been away for over a month and we had to handle the patients on our own, but some cases require the expertise of a doctor. It is heart-breaking to watch them die," she said.
The nurses said they often came to work on empty stomachs, but their employer was not taking them seriously.
Another nurse said they were exhausted and mentally unfit to give patients service that is up to the acceptable standard.
"Our families are at risk as well because infections like tuberculosis thrive in conditions such as the ones we are being exposed to," they said.
Parirenyatwa hospital spokesperson Linos Dhire said the health institution management had engaged the nurses' leadership and took note of their concerns.
"The major issues which they raised are outside the hospital's jurisdiction. We have forwarded their concerns to the ministry and the Health Service Board for consideration," Dhire said.
Opposition MDC leader, Nelson Chamisa made an impromptu visit to Harare Central and Parirenyatwa hospitals and demanded that Mnangagwa declares the health crisis a national disaster.
Harare Central is the busiest hospital in the country and reportedly treats over 1 200 in-patients and 900 out-patients daily.
Parirenyatwa attends some 1 000 patients daily.
Relatives of patients and nurses who spoke to Chamisa said patients who were admitted before the strike were dying because of lack of medical care, while those seeking help were being turned away because there were no doctors.
Chamisa described government's response to the strike by health personnel as "soft genocide".
A nurse who spoke to Chamisa on condition she was not named said they had collapsed three wards into one because there was no manpower at the hospital.
"New patients are not being admitted. Those already in the hospital have no medicines. No doctors are visiting them and most die not because they can't be cured, but because there is no care. Now we have collapsed all three wards into one so that at least we can manage," she said.
Susan Nyamakura, who was admitted at Harare Central Hospital on September 15 following a car accident, told NewsDay that she was yet to receive medical treatment.
"They told me the CT scan is not working, so I have to get to a private facility which is quoting in US dollars. The medication is also being sold in foreign currency, which I can ill afford and I am in serious pain. I need help," she said.
Chamisa said the situation at the hospitals was dire.
"The health situation in the country is unhealthy and has become a national emergency. It needs immediate rescue measures that can be implemented as soon as possible before more lives are lost," he said.
The MDC leader said his party would soon approach Mnangagwa to find a lasting solution to the problems facing the health sector and the country at large.
"I take it upon myself to make sure that I will do everything within my power to cause my brother ED Mnangagwa to see that this kind of a crisis, which is a political crisis, a crisis of governance, a crisis of leadership is costing people's lives," Chamisa said.
"The ordinary people do not have any other remedies, whereas those that are in leadership, those who are in government, who are in authority and power, who have access to mechanisms and other measures, would go to South Africa, would go to India and China yet they leave the taxpayers, the ordinary people who cannot have any other alternative, to die."
Harare Hospital chief executive Tinashe Dobbie tried to eject Chamisa from the hospital premises, accusing him of not seeking his clearance, but was stopped by the opposition leader's security.
Hospital security, however, blocked Chamisa and the media from entering other critical wards such as maternity section.
Health minister Obadiah Moyo referred questions to the ministry's spokesperson, Donald Mujiri, who said he could not speak as he was driving.
Previous: Zera dismisses social media fuel hike notice
Next: Zimbabwe economic reforms win IMF approval
Mbeki lands in Zimbabwe ahead of Mugabe's funeral
Zimbabweans celebrate Chihuri departure
New Zimdollar the worst-performing currency in the world
Zinara US$71 million worth of fully awarded non-performing contracts exposed


It works in the first process of gauze compress manufacturing. It cut the large width ) of ready-made absorbent gauze into required width and rewinds them into required legth for loading on the following Gauze Compress Folding Machines, Gauze roll making machines and Guaze krinkling line.
Pneumatic Air Shaft with Measuring Ruler for Winding.


Non-start turns over no spark or fuel pump run (relay may buzz) check ECU earth bolts onto engine block. Volt drop between earth and pins 1 and 2 on ECU, meter should read less than 0.5v when switched on, see meter.
This is a bad connection the voltage is trying to go through the meter.


text:
Download high-resolution image
Keeping an Eye Open
Essays on Art
Part of Vintage International
Author Julian Barnes
Knopf | Vintage
6.8"W x 8.6"H x 1"D
On sale Jun 13, 2017 | 288 Pages | 978-1-101-87337-3
The Arts > Art > Art Appreciation
The Arts > Art > Art History by Period > 19th Century
The Arts > Art > Art History by Topic > Art History Survey
Flaubert believed that great paintings required no words of explanation. But, as Barnes notes, it is a rare picture that stuns, or argues, us into silence. And when this does happen, we feel compelled to explain the very silence into which we have been plunged. In this illuminating collection of essays on art, Barnes turns his narrative gifts toward some of the most important paintings in the Western canon, eloquently voicing our reactions to these images—what they cause us to think and feel, and why. From Gericault's The Raft of the Medusa to Degas's The Dance Lesson to Braque's Cubism to the "good soft fun" of Oldenburg, Barnes effortlessly fits these pieces into the larger dramas of the artists' lives and works. Taken together, these essays give us a wonderful overview of art from Romanticism onward—and are a true pleasure to read.
"Eloquent. . . . This is a novelist's criticism, full of motion and drama." —The Washington Post
"An engaging and empathetic volume." —The New York Times Book Review
"Perceptive. . . . Generous and discerning." —The Boston Globe
"Fascinating and brilliant. . . . This magnificent survey draws its strength from its intensely personal focus, each piece reverberating off the others." —The Financial Times
"Illuminating. . . . Avid and thoughtful. . . . [Barnes] chatters like the gifted novelist he is, using his eye for the telling detail, his narrative intuition and his understanding of the creative process to help us see familiar artists like Degas, Braque and Magritte afresh, and to appreciate the work of lesser-known masters as well." —The New York Times
"[A] superb collection. . . . Barnes's observations and expression prov[e] equally adept and satisfying." —Minneapolis Star Tribune
"This is art writing of the first order. . . . Page after page, essay after essay, Barnes pulls off the sort of acrobatically erudite performance that ultimately draws as much admiration for him as for the art he describes." —Richmond Times-Dispatch
"Powerful accounts of interconnections between art and artist. . . . Sharply observed and richly illuminating. . . . Barnes has a wonderful eye for what makes a great picture, and a command of language that again and again allows readers to share what he sees." —Times Literary Supplement
"A readable, riveting, informed work with sharp, marvellous anecdotes and observations. . . . In this beautifully illustrated book you're in great company." —The Irish Independent
"Extremely rewarding, informative, attentive, thoughtful, entertaining." —The Evening Standard
"Barnes weaves biography, history, philosophy in this fascinating, richly illuminating and beautifully written book." —Art Quarterly
"It's both a pleasure and an education to look over Barnes's shoulder as he interrogates, wonders at, and relishes works of art. He's a critic who prioritizes the objects themselves, and his work is always satisfying." —Publishers Weekly (starred review)
"Scholarly and astute yet accessible and exciting. . . . Barnes focuses his analytical prowess on significant artists and their oeuvres, opening fresh vistas to readers—and viewers." —Kirkus Reviews (starred)
"Handsomely illustrated, superbly written, felicitously thought-provoking. . . . Barnes is a consummate stylist, not only because of his artistic command of language but also by virtue of his searching intelligence, incisive candor, rogue wit, and righteous fairness." —Booklist
"[Barnes] digs into fascinating details of isometric proportions. . . . Highly recommended to all art readers." —Library Journal
© Marzena Pogorzaly
JULIAN BARNES is the author of twenty-four previous books, for which he has received the Man Booker Prize, the Somerset Maugham Award, the E. M. Forster Award from the American Academy of Arts and Letters, the Prix Médicis and Prix Femina in France, and the Jerusalem Prize. In 2017 he was awarded the Légion d'honneur. His work has been translated into more than forty languages. He lives in London. View titles by Julian Barnes
Géricault: Catastrophe into Art
It began with a portent.
They had doubled Cape Finisterre and were sailing south before a fresh wind when a school of porpoises surrounded the frigate. Those on board crowded the poop and the breastwork, marvelling at the animals' ability to circle a vessel already gaily proceeding at nine or ten knots. But as they watched the sporting of the porpoises, a cry was raised. A cabin boy had fallen through one of the fore portholes on the larboard side. A signal gun was fired, a life-raft thrown out, and the vessel hove to. But these manoeuvres were cumbrously done, and by the time the six-oared barge was let down, it was in vain. They could not find the raft, let alone the boy. He was only fifteen years old, and those who knew him maintained that he was a strong swimmer; they conjectured that he would most probably have reached the raft. If so, he doubtless perished upon it, after having experienced the most cruel sufferings.
The expedition for Senegal consisted of four vessels: a frigate, a corvette, a flute and a brig. It had set sail from the Island of Aix on 17th June 1816 with 365 people on board. Now it continued south with its complement reduced by one. They provisioned at Tenerife, taking on precious wines, oranges, lemons, banian figs and vegetables of all kinds. Here they noted the depravity of the local inhabitants: the women of Saint Croix stood at their doors and urged the Frenchmen to enter, confident that their husbands' jealousies would be cured by the monks of the Inquisition who would speak disapprovingly of conjugal mania as the blinding gift of Satan. Reflective passengers ascribed such behaviour to the southern sun, whose power, it is known, weakens both natural and moral bonds.
From Tenerife they sailed south-south-west. Fresh winds and navigational ineptitude scattered the flotilla. Alone, the frigate passed the tropic and rounded Cape Barbas. It was running close to the shore, at times no more than half a cannon shot away. The sea was strewn with rocks; brigantines could not frequent these seas at low water. They had doubled Cape Blanco, or so they believed, when they found themselves in shallows; the lead was cast every half-hour. At daybreak Mr. Maudet, ensign of the watch, made out the reckoning upon a chicken coop, and judged that they were on the edge of the Arguin reef. His advice was discounted. But even those unschooled in the sea could observe that the water had changed colour; weed was apparent at the ship's side, and a great many fish were being taken. In calm seas and clear weather, they were running aground. The lead announced eighteen fathoms, then shortly afterwards six fathoms. The frigate, luffing, almost immediately gave a heel; a second and third, then stopped. The sounding line showed a depth of five metres and sixty centimetres.
By misfortune, they had struck the reef at high tide; and the seas growing violent, attempts to free the ship failed. The frigate was assuredly lost. Since the boats it carried were not capacious enough to contain the whole personnel, it was decided to build a raft and embark upon it those who could not be put into the boats. The raft would then be towed to the shore and all would be saved. This plan was perfectly well laid; but as two of the company were later to affirm, it was traced upon loose sand, which was dispersed by the breath of egotism.
The raft was made, and well made, places in the boats allotted, provisions made ready. At daybreak, with two metres and seventy centimetres of water in the hold and the pumps failing, the order was given to abandon ship. Yet disorder quickly embraced the well-laid plan. The allotment of places was ignored, and the provisions were carelessly handled, forgotten or lost in the waters. One hundred and fifty was to be the complement of the raft: 120 soldiers, including officers, twenty-nine sailors and male passengers, one woman. But scarcely had fifty men got on board this machine—whose extent was twenty metres in length and seven in breadth—than it sank under the water to a depth of at least seventy centimetres. They cast off the barrels of flour which had been embarked, whereupon the level of the raft rose; the remaining people descended upon it, and it sank again. When the machine was fully laden, it was a metre beneath the surface, and those on board so crowded they could not take a single step; at the back and front, they were in water up to the waist. Loose flour barrels were cast against them by the waves; a twenty-five-pound bag of biscuit was thrown down to them, which the water converted at once into a paste.
It had been intended that one of the naval officers should take command of the raft; but this officer declined to come on board. At seven o'clock in the morning the signal for departure was given, and the little flotilla pulled away from the abandoned frigate. Seventeen persons had refused to leave the vessel, or had concealed themselves away, and thus remained on board to discover their fate.
The raft was towed by four boats in line astern, preceded by a pinnace, which made soundings. As the boats took up their positions, cries of Vive le roi! arose from the men on the raft, and a small white flag was raised upon the end of a musket. But it was at this instant of greatest hope and expectation for those upon the raft that the breath of egotism was added to the normal winds of the sea. One by one, whether for reason of self-interest, incompetence, misfortune or seeming necessity, the tow-ropes were cast aside.
The raft was barely two leagues from the frigate when it was abandoned. Those on board had wine, a little brandy, some water and a small portion of sodden biscuit. They had been given no compass or chart. With neither oars nor rudder, there was no means of controlling the raft, and little means either of controlling those upon it, who were constantly flung against one another as the waters rolled over them. In the first night, a storm got up and threw the machine with great violence; the cries of those on board mingled with the roaring of the billows. Some attached ropes to the timbers of the craft, and held fast to these; all were buffeted without mercy. By daybreak the air was filled with lamentable cries; vows which could never be fulfilled were offered up to Heaven, and all prepared themselves for imminent death. It was impossible to form an idea of that first night which was not below the truth.
The next day the seas were calm, and for many hope was rekindled. Nevertheless, two young lads and a baker, convinced that there was no escape from death, bade farewell to their companions and willingly embraced the sea. It was during this day that those on the raft began to experience their first delusions. Some fancied that they saw land, others espied vessels come to save them, and the dashing of these deceptive hopes upon the rocks provoked greater despondency.
The second night was more terrible than the first. The seas were mountainous and the raft constantly near to being overthrown; the officers, clustered by the short mast, ordered the soldiery from one side of the machine to the other to counterbalance the energy of the waves. A group of men, certain that they were lost, broke open a cask of wine and resolved to soothe their last moments by abandoning the power of reason; in which they succeeded, until the sea water coming in through the hole they had made in the cask spoiled the wine. Thus doubly maddened, these disordered men determined to send all to a common destruction, and to this end attacked the ropes that bound the raft together. The mutineers being resisted, a pitched battle took place amid the waves and the darkness of the night. Order was restored, and there was an hour of tranquillity upon that fatal machine. But at midnight the soldiery rose again and attacked their superiors with knives and sabres; those without weapons were so deranged that they attempted to tear at the officers with their teeth, and many bites were endured. Men were thrown into the sea, bludgeoned, stabbed; two barrels of wine were thrown overboard and the last of the water. By the time the villains were subdued, the raft was laden with corpses.
During the first uprising, a workman by the name of Dominique, who had joined the mutineers, was cast into the sea. On hearing the piteous cries of this treacherous underling, the engineer in charge of the workmen threw himself into the water and, taking the villain by the hair, succeeded in dragging him back on board. Dominique's head had been split open by a sabre. In the darkness the wound was bound up and the wretch restored to life. But no sooner was he so revived than ingratitude overtook him; he joined the mutineers and rose with them again. This time he found less fortune and less mercy; he perished that night.
Delirium now menaced the unhappy survivors. Some threw themselves into the sea; some fell into torpor; some unfortunate wretches rushed at their comrades with sabres drawn, demanding to be given the wing of a chicken. The engineer whose bravery had saved the workman Dominique pictured himself travelling the fine plains of Italy, and one of the officers saying to him, "I remember that we have been deserted by the boats; but fear nothing; I have just written to the governor, and in a few hours we will be saved." The engineer, calm in his delirium, responded thus: "Have you a pigeon to carry your orders with as much celerity?"
Only one cask of wine remained for the sixty still on board the raft. They collected tags from the soldiers and fashioned them into fish-hooks; they took a bayonet and bent it into such shape as to catch a shark. Whereupon a shark arrived, and seized the bayonet, and with a savage twist of its jaw straightened it fully out again, and swam away.
An extreme resource proved necessary to prolong their miserable existence. Some of those who had survived the night of the mutiny fell upon the corpses and hacked pieces from them, devouring the flesh upon the instant. Most of the officers refused this meat; though one proposed that it should first be dried to make it more palatable. Some tried chewing sword-belts and cartouche boxes, and the leather trimmings to their hats, with little benefit. One sailor attempted to eat his own excrement, but he could not succeed.
The third day was calm and fine. They took repose, but cruel dreams added to the horrors already inflicted by hunger and thirst. The raft, which now carried less than one half its original complement, had risen up in the water, an unforeseen benefit of the night's mutinies. Yet those on board remained in water to the knees, and could only repose standing up, pressed against one another in a solid mass. On the fourth morning they perceived that a dozen of their fellows had died in the night; the bodies were given to the sea, except for one that was reserved against their hunger. At four o'clock that afternoon a shoal of flying fish passed over the raft, and many became ensnared in the extremities of the machine. That night they dressed the fish, but their hunger was so great and each portion so exiguous that many of them added human flesh to the fish, and the flesh being dressed was found less repugnant. Even the officers began to eat it when presented in this form.
It was from this day onwards that all learned to consume human flesh. The next night was to bring a fresh supply. Some Spaniards, Italians and Negroes, who had remained neutral during the first mutinies, conspired together with the plan of throwing their superiors overboard and escaping to the shore, which they believed to be at hand, with those valuables and possessions that had been placed into a bag and hung upon the mast. Once more, a terrible combat ensued, and blood washed over the fatal raft. When this third mutiny was finally suppressed, there remained no more than thirty on board, and the raft had risen yet again in the water. Barely a man lay without wounds, into which salt water constantly flowed, and piercing cries were heard.
On the seventh day two soldiers concealed themselves behind the last barrel of wine. They struck a hole in it and began to drink the wine through a straw. On being discovered, the two trespassers were instantly cast into the water, in accordance with the necessary law that had been promulgated.
It was now that the most terrible decision came to be taken. On counting their numbers, it was found that they were twenty-seven. Fifteen of these were likely to live for some days; the rest, suffering from large wounds and many of them delirious, had but the smallest chance of survival. In the time that might elapse before their deaths, however, they would surely diminish further the limited supply of provisions. It was calculated that they could well drink between them as many as thirty or forty bottles of wine. To put the sick on half-allowance was to kill them by degrees. And thus, after a debate in which the most dreadful despair presided, it was agreed among the fifteen healthy persons that their sick comrades must, for the common good of those who might yet survive, be cast into the sea. Three sailors and a soldier, their hearts now hardened by the constant sight of death, performed these repugnant but necessary executions. The healthy were separated from the unhealthy like the clean from the unclean.
After this cruel sacrifice, the last fifteen survivors threw all their arms into the water, reserving only a sabre lest some rope or wood might need cutting. There was sustenance left for six days while they awaited death.
Then came a small event which each interpreted according to his nature. A white butterfly, of a species common in France, appeared over their heads fluttering, and settled upon the sail. To some, crazed with hunger, it seemed that even this could make a morsel. To others, the ease with which their visitor moved appeared a very mockery of those who lay exhausted and almost motionless beneath it. To yet others, this simple butterfly was a sign, a messenger from Heaven as white as Noah's dove. Even those sceptical ones who declined to recognise a divine instrument knew that butterflies travel little distance from the dry land, and were raised by cautious hope.
Copyright © 2015 by Julian Barnes. All rights reserved. No part of this excerpt may be reproduced or reprinted without permission in writing from the publisher.
"Enchanting ... eloquent.... This is a novelist's criticism, full of motion and drama." —The Washington Post
More Than I Love My Life
The Living Sea of Waking Dreams
Richard Flanagan
Antiquities and Other Stories
Let Me Tell You What I Mean
Season of Anomy
The Interpreters
Think, Write, Speak
Uncollected Essays, Reviews, Interviews, and Letters to the Editor
Brian Boyd, Vladimir Nabokov Literary Trust
The Wapshot Chronicle
Love in the Time of Cholera (Illustrated Edition)
The Scandal of the Century
And Other Writings
Personal Writings
Berta Isla
Javier Marías
Life for Sale
The Source of Self-Regard
Selected Essays, Speeches, and Meditations
Myra Breckinridge
Warlight
I'm Not Here to Give a Speech
The Myth of Sisyphus
Between Eternities
Men Without Women
The Boat Rocker
Absolutely on Music
Haruki Murakami, Seiji Ozawa
A Companion Edition to the Documentary Film Directed by Raoul Peck
James Baldwin, Raoul Peck
Wind/Pinball
Hear the Wind Sing and Pinball, 1973 (Two Novels)
God Help the Child
The Buried Giant
Peter Carey
The Prophet
Colorless Tsukuru Tazaki and His Years of Pilgrimage
The Narrow Road to the Deep North
The News: A User's Manual
Giovanni's Room
The Complete Stories
Religion for Atheists
A Non-believer's Guide to the Uses of Religion
Seventeen Essays and a Short Story
Introduction by Salman Rushdie
The Cat's Table
The Sense of an Ending
I Love a Broad Margin to My Life
The Naive and the Sentimental Novelist
Understanding What Happens When We Write and Read Novels
The Masque of Africa
Glimpses of African Belief
V. S. Naipaul
Introduction by Pico Iyer
The Cross of Redemption
Uncollected Writings
David Malouf
Nevil Shute
MASTER HAROLD AND THE BOYS
A Play
Athol Fugard
Duino Elegies & The Sonnets to Orpheus
A Dual-Language Edition
A Mercy
Introduction by Robert Stone
Michael Herr
Travels with Herodotus
Ryszard Kapuscinski
The Architecture of Happiness
The Bluest Eye
Selected Poems of W. H. Auden
Mimi and Toutou's Big Adventure
The Bizarre Battle of Lake Tanganyika
Giles Foden
Last Night
Kafka on the Shore
Too Brief a Treat
The Letters of Truman Capote
Status Anxiety
The City and the Pillar
The Razor's Edge
You're an Animal, Viskovitz
Alessandro Boffa
Selected Essays of John Berger
The Shape of a Pocket
Caryl Phillips
A Wild Sheep Chase
The Shadow of the Sun
A Fine Balance
Quarrel & Quandary
Nothing to Be Frightened Of
Flaubert's Parrot


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ITIL v.3 Foundations: The Foundation Level is the entry level qualification which offers candidates a general awareness of the key elements, concepts and terminology used in the ITIL Service Lifecycle, including the linkages between Lifecycle stages, the processes used and their contribution to Service Management practices.
Network+: (Network Plus) is a mid-level certification for network technicians. This certification is designed to test the competency of a mid-level network technician in supporting and configuring TCP/IP clients in terms of network design, cabling, hardware setup, configuration, installation, support, and troubleshooting.
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OSCP: Offensive Security Certified Professional is an ethical hacking certification.
GWAPT: GIAC Web Application Penetration Tester.


text:
Alicia rhadina is een zeeanemonensoort uit de familie van de Aliciidae. De wetenschappelijke naam van de soort is voor het eerst geldig gepubliceerd in 1893 door Haddon & Shackleton.

Zeeanemonen


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text:
Home Spotlight Drawing First Blood
To Transplant or Not To Transplant in First Remission?
Navneet Majhail, MD
Director of the Blood & Marrow Transplant Program at Cleveland Clinic Taussig Cancer Institute in Cleveland, Ohio
Alan K. Burnett, MD
Head of the department of hematology at the Cardiff University School of Medicine in Cardiff, United Kingdom
Most patients with newly diagnosed acute myeloid leukemia (AML) will achieve a first complete remission with standard induction chemotherapy. Durable remission or cure can only be attained, though, with further treatment – either post-remission consolidation chemotherapy or hematopoietic cell transplant. Questions about the optimal timing of transplant, as well as which patients will benefit from the procedure, remain an area of debate.
In this edition of "Drawing First Blood," ASH Clinical News has invited Navneet Majhail, MD, MS, and Alan K. Burnett, MD, to debate the question: Should intermediate-risk AML be transplanted in first complete remission? Dr. Majhail will argue for transplant and Dr. Burnett will argue against.
Navneet Majhail, MD: In the debate about whether or not to transplant in first complete remission (CR1) in intermediate-risk AML patients, we have to acknowledge that the definition of "intermediate risk" is a moving target. There are several different types of diseases within the broad category of intermediate-risk AML – depending on a patient's cytogenetic factors, molecular markers, and other prognostic markers.
Alan K. Burnett, MD: This is certainly an evolving field, and actually defining "intermediate risk" is complex. There are few data showing that patients' survival is made worse by transplant, so I think the debate, really, is about the optimal use of the procedure – selecting the appropriate candidates who will benefit from transplant and whether it should be used in CR1 or later if needed.
Dr. Majhail: I think there have been great improvements in transplantation technologies and risk prediction that make transplant in CR1 the best option for properly selected patients.
Traditionally, cytogenetic markers have been used to classify patients' risk levels, and, with the introduction of molecular markers like NPM1 and FLT3, we are able to further refine intermediate-risk patients – especially those who have a normal karyotype. We also have emerging data about the role of the allelic ratio (the ratio of FLT3-ITD/FLT3 wild-type) in predicting a patient's risk of relapse.
But, until those data are validated, I would say the presence of an FLT3-ITD mutation in patients with normal karyotype or intermediate-risk disease qualifies patients for transplant in CR1.
Dr. Burnett: Within the intermediate-risk category defined by cytogenetics, though, we have to remember that not all mutations or markers indicate a poor prognosis. FLT3 and NPM1 have always been the biggest actors. In the UK for example, we use a validated weighted score to further determine a patient's risk of relapse. In addition to cytogenetics, the score takes into account a patient's white blood cell count at presentation, the response to induction chemotherapy, and whether a patient has secondary or de novo disease at presentation. This score has allowed us to identify about 20 percent of intermediate-risk patients (by cytogenetics) with a worse-than-average prognosis where transplant should be used.
Seventy-five percent of the high-risk patients defined by this score had an FLT3-ITD mutation. To decide whether the remaining 25 percent of FLT3-mutated patients are candidates for transplant in CR1, we use the interplay between FLT3 and NPM1. If a patient has an FLT3 mutation without associated mutant NPM1, he or she is at higher risk of relapse and benefits from a myeloablative transplant. For patients with FLT3 and associated NPM1 mutations, however, we do not have definitive evidence that they benefit from – or, for that matter, are harmed by – transplant.
Additionally, mutations in the CCAAT/enhancer binding protein-alpha (CEBPA) gene are associated with a relatively favorable prognosis especially if the mutation is bi-alleilic, so, for the approximately five to 10 percent of patients who have CEBPA mutations, transplant can be avoided.
Dr. Majhail: I agree, there are definite cases where the evidence does not support transplant. Even in our practice, patients with normal karyotype who have no other abnormalities but are either NPM1-mutated or have the biallelic CEBPA mutation are not offered transplant in CR1. Having said that, as we discussed earlier, the whole definition of intermediate risk is evolving.
Newer molecular mutations, such as DNMT3A or IDH1 and IDH2, are giving us more information about patients with a normal karyotype and higher risk of relapse. As we learn more about these mutations and their prognostic role in AML, I believe they will also help us better identify candidates for upfront transplant versus consolidation chemotherapy.
Looking at the existing data, I think certain subgroups of patients you identified might still be candidates for an allogeneic transplant in CR1. In a meta-analysis of 24 prospective clinical trials, for instance, Koreth et al. clearly showed that, for intermediate-risk AML patients, transplant provided an advantage for both overall and relapse-free survival.1
Dr. Burnett: Well, like you said, transplantation in AML is a moving field, so it seems like that meta-analysis is more a review of the history of transplantation, where the analyses were done on a "donor versus no donor" basis. This sort of analysis is a surrogate for randomization, but not all donors were transplanted in CR1 or at all, and not all "no donor" patients did not receive transplant in CR1.
Now, while transplant was clearly beneficial to event-free survival, when we start looking at the overall survival, I think that benefit becomes less clear. Obviously, there is some risk associated with forgoing transplant at CR1 because the patient may not reach second complete remission (CR2). The literature points to several features as predictive of relapse risk, but we must be careful not to assume that presence of these features means a patient will automatically benefit from transplant.
For example, would a patient with the monosomal karyotype benefit from transplant? This karyotype is associated with a very poor prognosis, but does a transplant help? It is our only treatment option, so we will go ahead with transplant, but I'm not sure it does our patients any good.
Yes, there are very few data suggesting that intermediate-risk patients undergoing transplant will have shorter survival, but we do know that a transplant is tough on patients. It can leave them with chronic debilitating problems. Therefore, we also need to focus in on the patients who do not need a transplant.
In that vein, residual disease measurement is a very influential predictor of outcome of transplant. . The data tell us that, if a patient is negative for minimal residual disease (MRD) and undergoes transplant, he or she will likely have a very good outcome; if a patient is positive with MRD, he or she won't. MRD is also particularly interesting because it allows you to tailor treatment to the individual patient – rather than to use information about average outcomes. I think this could be a very important step forward in defining who needs what in terms of further treatment.
Dr. Majhail: Now, speaking of the literature on this topic, I wanted to look at a 2013 paper in the Journal of Clinical Oncology that analyzed outcomes and survival in patients in the Medical Research Council AML10, 12, and 15 trials, which included 3,415 patients who entered CR1 (2,029 were intermediate-risk patients).2
Of the total population, one-third received a transplant in CR1. Overall, 1,271 patients (60%) who did not receive transplant in CR1 relapsed (61% of these patients were considered intermediate-risk according to their cytogenetic profile). Only half of these patients (642 people) eventually achieved CR2 (59% of whom were intermediate-risk patients).
Essentially, of all patients who relapsed without a transplant in CR1, only one-third went on to receive a transplant in CR2. The numbers were similar when considering the specific subgroup of intermediate-risk patients, in which, again, only one-third of all patients who relapsed received a transplant.
When patients were transplanted in CR2, their survival was lower than what might be expected for transplantation in CR1. Keeping in mind that these data represent patients enrolled on those trials, I can deduce that many intermediate-risk AML patients will eventually relapse and, among those who relapse, only half will eventually achieve CR2. At the end of the day, a majority of patients do not end up getting to a transplant and are not able to receive any of the procedure's potential benefits. Even if you disagree with universal transplant in CR1 in these patients, you have to agree that there is value in at least considering it for appropriate patients.
Dr. Burnett: Our interpretations of those data are a bit different: You are correct that only about 50 percent of patients with intermediate risk will achieve CR2 and about one-third of the patients got a transplant in CR2.
Generally speaking, about 20 to 25 percent of patients can be rescued if there is a donor readily available. To me, these data tell me that a proportion of intermediate-risk patients can be salvaged. In an event-free analysis this group is excluded. These numbers have to be added to the numbers of patients who survive with chemotherapy in CR1. This illustrates why overall survival is an important endpoint to consider, rather than just event-free survival.
Dr. Majhail: One has to keep in mind that survival after transplant in general has improved considerably over the past few decades. The relatively high rates of transplant-related mortality that were reported in historical studies are really not reflective of the supportive care we routinely offer patients today. We are getting better at choosing patients for transplantation, including incorporating newer factors into the decision process.
Of course, the decision gets even more complex in older patients. AML is typically a disease of older patients, who carry more comorbidities than younger patients do. Newer instruments, like the HCT Comorbidity Index and the EBMT risk score, are helping us better classify the risk of transplant-related mortality. Also, availability of a donor is no longer a barrier to transplantation; with an increasing pool of unrelated donors and with umbilical cord blood and haplo-identical donor sources becoming more mainstream, essentially all patients who need an allogeneic transplant have a potential donor.
To change direction a bit, we should discuss older patients with AML – a group that has universally poor outcomes with chemotherapy only and should be considered, if appropriate, for transplant in CR1. Reduced-intensity conditioning (RIC) transplantation offers a relatively low risk of transplant-related mortality and opens up the possibility of allogeneic transplantation for older patients with AML. RIC transplant seems to produce lower relapse and better leukemia-free survival than chemotherapy alone. One can argue that transplant should be strongly considered for appropriately selected older patients with intermediate-risk AML in CR1.
Dr. Burnett: For an older patient who is in otherwise good condition, there is no question in my mind that RIC transplant should be considered. In our experiences with older patients – in about 100 to 150 patients older than 60 years – there is little evidence that these patients benefit from consolidation chemotherapy. The odds of any level of survival after relapse are low for these patients, so, obviously, delaying a transplant when the opportunity is there is inadvisable.
However, when our investigators looked into RIC transplants in older patients, they found that, in fact, less than 10 percent of older patients in remission end up going down this route. I do think a proportion of older patients could benefit from the RIC transplant but are not currently being offered it due to many factors – perhaps the comorbidity burden rules out this approach, or the donor might not be medically suitable.
People used to believe that RIC transplant would never work in AML, citing its poor graft-versus-leukemia effect and the fact that it takes time for RIC transplant to produce some effect – by which time the patient has probably relapsed. I think we are at a point now where we can control leukemia, and RIC transplant is a feasible way to do so. Ultimately, though, the choice will depend on what we learn in future years about the best conditioning schedule for RIC transplant.
Dr. Majhail: With all the new research in the field of AML, I think we can expect perspectives in this debate to continue to change. Newer therapies, including FLT3-inhibitors and IDH2 inhibitors, may change the "control arm" for transplant.
We can at least agree that all patients with intermediate-risk disease should get a transplant consult early in their disease course. The last thing we want is a delayed transplant in a transplant-eligible patient, or to see a patient relapse while waiting for transplant. So, treatment of these patients should be a collaborative effort between the leukemia physician and the transplant physician.
Dr. Burnett: I agree – the feasibility of transplant has to be known very early in a patient's management. Perhaps the discussion we need to have with patients is not "to transplant or not to transplant," but whether he or she needs the transplant now or later, after demonstrating an absolute need for it.
Koreth J, Schlenk R, Kopecky KJ, et al. Allogeneic stem cell transplantation for acute myeloid leukemia in first complete remission: systematic review and meta-analysis of prospective clinical trials. JAMA. 2009;301:2349-61.
Burnett AK, Goldstone A, Hills RK, et al. Curability of patients with acute myeloid leukemia who did not undergo transplantation in first remission. J Clin Oncol. 2013;31:1293-1301.
Burnett AK, Hills RK, Wheatley K, et al. Sensitive risk score for directing treatment in younger patients with AML. Blood. 2006;108:10a (Abstract 18).


Think Tri! eat, sleep, everything triathlons: What to ride to, Hulu.com!
OK the winter is almost up so getting out and ridding is coming, soon. Next year if HULU can hang on and go up against YouTube, spending hours on the trainer won't feel so bad. You can watch almost any show and tons of movies, for free. This is from their "about us" section.
Hulu's ambitious and never-ending mission is to help you find and enjoy the world's premium content when, where and how you want it. We hope to provide you with the web's most comprehensive selection from more than 50 content providers including FOX, NBC, MGM, Sony Pictures Television, Warner Bros., Lionsgate, and more to deliver premium programming across all genres and formats, television shows, feature films, and clips. Watch full-length episodes of current primetime TV shows such as The Simpsons and The Office the morning after they air, classics like Miami Vice and Buffy the Vampire Slayer, and clips from Saturday Night Live, Nip/Tuck, and others. Hulu also offers full-length feature films like The Usual Suspects, Ice Age, Three Amigos!, and The Big Lebowski as well as clips from films such as Napoleon Dynamite, The 40 Year Old Virgin, Devil Wears Prada and many more. Hulu is free and ad-supported — available anytime in the U.S.
Hulu was founded in March 2007 and is a joint venture owned by NBC Universal and News Corp. In addition, Hulu has closed a $100 million investment from private equity firm Providence Equity Partners.


FORT SAM HOUSTON — Charlie waited in a relatively empty lounge. It was a Saturday, and most of the lounge's usual visitors — the people he was there to see — were out of town. But Charlie wore his typical content expression, and when a young man using a cane walked in, the man immediately recognized Charlie and gave him a hug.
Charlie licked him in return.
For the wounded soldiers at the Fort Sam Houston Warrior and Family Support Center who know the golden retriever by name, Charlie does not bite or bark. He does not judge. He is friendly and accepting, feeding off the affections of wounded men and women who miss their families, pets or both.
Soldiers at the 3-year-old center who face months or years of recovery at the nearby Brooke Army Medical Center say Charlie's visits give them respite from the memories of war, the pain of recovery and the loneliness of not having friends or family nearby.
Not just anyone can take their pet to facilities like this — Charlie is a trained and registered therapy animal. But his Corpus Christi owners, who make 310-mile round trips once a week to the center, say there is something about Charlie that transcends that training — they say he's special. "He loves all people," said owner Michele Yehezkely, 47. "He really enjoys every moment."
Michele and husband, Amir, know that many of the 600 soldiers receiving treatment at the medical center — site of the Defense Department's only burn unit — are too far from home to see their own loved ones. And the veterans who know Charlie agree on one thing: When he licks their hands or wags his tail, he is not doing it out of pity.
Army Spc. Jeff Srisourath lumbered up stairs at the center using a cane in September. After reaching the lounge, Srisourath, 24, politely said "hi" to the Yehezkelys, then leaned on his cane to greet Charlie.
"Hey, Charlie," Srisourath said as he roughly ran both hands through Charlie's thick golden mane. Charlie excitedly licked Srisourath's hands.
The Minnesota National Guard member was driving a Bradley Fighting Vehicle in Camp Fallujah, Iraq, 11 months ago when an improvised explosive device blew through it.
Srisourath blacked out. When he woke up, he angrily stood and raised his weapon, and then went back down. The blast had removed his left boot and shattered that ankle, making it swell to twice its size. Srisourath has been receiving physical therapy at the medical center ever since and expects to be there another five months. His foot has bones fused in several places and can't move from side to side.
And he has other problems. "Any loud noise I hear gets me startled," he said. "Anything that sounds familiar to a gunshot gives me flashbacks. I can't sleep for, like, five days straight sometimes. "Recovery is physical and mental."
Srisourath, whose family lives in Minnesota and Hawaii, said Charlie reminds wounded soldiers of home, and simpler times.
"Say they have dogs at home, and they really can't get home," he said. "This dog helps them mentally. He gives them assurance. They seem more relaxed and calm."
The center typically receives about 5,000 visits from the public each month, but the number of animal-therapy visitors to the center has grown in recent years, said Warrior and Family Support Center Program Coordinator Judith Markelz.
"The animal therapy people came to us, and I thought it was a wonderful idea," she said. "These men are adjusting back to society — they are never going to be the same person. This makes the transition a little easier."
The first animal-therapy visitor showed up there two years ago, Markelz said. There now are six regular visitors, including the Yehezkelys, who bring their trained pets to the wounded soldiers.
"I have always wanted to do something for the soldiers," said Amir Yehezkely, a native of Israel. "And we can see that Charlie does positive things by socializing with them."
The couple moved to Corpus Christi from New York in February 2005 and wanted two things: a way to give to the military community and a golden retriever. They found Charlie to be the friendliest among a litter of puppies soon after moving to South Texas, and learned about the center through an Internet search.
Michele Yehezkely became interested after reading about animal therapy, and the couple spent several months earlier this year training Charlie on their own. They socialized him by taking him to the beach, the store and other places.
"We went out with Charlie as often as we could; we took him out to public places, where he would get used to interacting with people," she said.
Army Spc. Isaac Morgan, who suffered brain damage and memory loss from being near about 20 explosions while in Iraq, said even if a wounded veteran does not have a pet at home, Charlie is a change of pace from the cold, sterile hospital environment, and helps distance them from what he called the 360-degree Iraqi battlefield.
"Most of us have been staying in the hospital," said Morgan, a 20-year-old San Francisco native who served in Iraq from April to July and has been at the center since late summer. "You don't see anything but doctors. It's nice to see something from the outside."
Warrior and Family Support Center staff refer anyone interested in being an animal-therapy volunteer to register their pet through Delta Society, a nonprofit group based in Bellevue, Wash., that trains volunteers and registers them and their pets to volunteer at health-care facilities.
Delta registers any domestic animal that has shown it has been trained or is of the right temperament for dealing with strangers; it also requires owners to take training courses for dealing with people who are victims of trauma. It cost the Yehezkelys about $300 to train Charlie at a local facility and register him through the organization.
Delta Society research support worker Michelle Cobey said the organization has not kept track of how many volunteers have trained to visit wounded soldiers but said she's noticed more of them. "Research shows contact with animals reduces blood pressure and has other health benefits," she said. "It's also a motivational thing for people in therapy to continue with their exercises." The organization has registered dogs, cats, rabbits and llamas.
Cobey said that with animal-therapy volunteers, both ends of the leash are important. While Charlie never has experienced conflict, his owners have.
Private investor Amir Yehezkely, 42 and a member of the Westside Rotary Club, served in the Israeli Air Force from 1985 to 1988. "I know what it's like to be left on the base for the weekend and how important it is for someone to come see you," he said. "I understand what it's like when someone cares."
He learned early about the sacrifices of war, with an assignment he and other Israeli primary school students had to complete in October 1973. Israeli forces were fighting back advancing Egyptian and Syrian troops in the three-week Yom Kippur War.
"The teacher asked us each to send a letter to a soldier," Yehezkely said. He sent a package of cards, chocolate and other items and said he never expected to hear back from the soldier. "Weeks later I got a letter from the soldier, telling me how much he enjoyed the package — especially the letter. I know how effective it is to have support from civilians."
Years after his own service in the Israeli military, he moved to New York and married his wife in August 1996. In 2001, Michele Yehezkely was a Washington Heights public school teacher about 20 minutes away from the World Trade Center that September.
When planes were flown into the towers one morning, administrators told staff no one was allowed to leave or enter the school.
"It tells the whole story when you see someone scrambling to pick up their child," Michele Yehezkely said. "It was a terrifying day for all the U.S., but highlighted (for me) by the fact that I could see the smoke."
After moving to Corpus Christi and finding Charlie, they decided he would be the best way to give back.
Research on the benefits of contact with animals during healing is not new. State University of New York researcher Karen Allen in 1995 reported that in a study of 48 people with physical impairments ranging from muscular dystrophy to spinal cord injury, within six months of being provided with service animals the participants as a whole needed 70 percent fewer hours of home care.
But the physically wounded are not the only ones who need support. During their visits to the hospital, the Yehezkelys comfort families with relatives receiving treatment. The support center is equipped with video games, Internet-connected computers, baked goods and toys for family members who go there when their relatives can't receive visitors at the hospital.
Charlie pulled away from his owners last spring and walked up to a woman whose son — wounded in Afghanistan — was hospitalized at the medical center. Amir watched from a distance as Charlie comforted the woman for the next hour.
"She literally sat down with Charlie for an hour, and it looked like they were both getting a lot out of it," he said.
The woman's son died in September, but she has stayed in contact with the Yehezkelys since then.
"People sometimes ask me how a dog can help," Amir Yehezkely said. "I say it's very easy for a person to hug a dog. It's not easy for them to hug me."
The Delta Society informs owners that their pets may get fatigued of human contact after several hours at treatment facilities, but the Yehezkelys said Charlie can stay at the center for as many as six hours.
"They say dogs emotionally can only take so much," Amir Yehezkely said. "In our case, we find Charlie is unlimited. He accepts people in all social situations."
The couple received a letter last month from the woman whose son died in September. It reminded Amir Yehezkely of the Israeli soldier.
"She asked us to pray for her and think positive thoughts," he said. "She also asked if Charlie ever becomes a father, she would love to have one of his sons.
"We replied, 'Of course.' "
The Delta Society is a national nonprofit organization that trains and registers pets and their owners for the pets to act as animal therapists for ill or disabled individuals.
Want to know more about Charlie?
Hobbies: Running on the beach, digging holes, playing Frisbee and tearing bark off of palm trees.
Serves: Wounded veterans and visiting family members by providing diversions such as Internet, DVDs and games. About 600 veterans are being treated at the medical center.
Some of the articles indexed through this page contain copyrighted material, the use of which has not always been specifically authorized by the copyright owner. I am making such material available in my efforts to advance understanding of social justice and human bond issues, among others. I believe this constitutes a 'fair use' of any such copyrighted material as provided for in section 107 of the US Copyright Law. In accordance with Title 17 U.S.C. Section 107, the material in this article is distributed without profit for research and educational purposes.


text:
Sharp Objects (Paperback)
By Gillian Flynn
Broadway Books, 9780307341556, 272pp.
Publication Date: July 31, 2007
Library Binding, Large Print (10/24/2018)
Prebound (7/31/2007)
CD-Audio (7/2/2013)
Compact Disc (10/1/2006)
AN HBO® LIMITED SERIES STARRING AMY ADAMS
Fresh from a brief stay at a psych hospital, reporter Camille Preaker faces a troubling assignment: she must return to her tiny hometown to cover the murders of two preteen girls. For years, Camille has hardly spoken to her neurotic, hypochondriac mother or to the half-sister she barely knows: a beautiful thirteen-year-old with an eerie grip on the town. Now, installed in her old bedroom in her family's Victorian mansion, Camille finds herself identifying with the young victims—a bit too strongly. Dogged by her own demons, she must unravel the psychological puzzle of her own past if she wants to get the story—and survive this homecoming.
GILLIAN FLYNN is the author of the #1 New York Times bestseller Gone Girl, for which she wrote the Golden Globe-nominated screenplay, and the New York Times bestsellers Dark Places and Sharp Objects. A former critic for Entertainment Weekly, she lives in Chicago with her husband and children.
Praise For Sharp Objects: A Novel…
"A first novel that reads like the accomplished work of a long-time pro, the book draws you in and keeps you reading with the force of a pure but nasty addiction...Flynn's book goes deeper than your average thriller. It has all the narrative drive of a serious pop novel and much of the psychological complexity of a mainstream character study. All in all, a terrific debut."
—Alan Cheuse, The Chicago Tribune
"A compulsively readable psychological thriller that marks [a] dazzling debut...[Flynn] has written a clever crime story with astonishing twists and turns, and enough suspense for the most demanding fans of the genre. But it is the sensitive yet disturbing depiction of her heroine that makes this an especially engrossing story...Flynn's empathic understanding of her major characters leads to storytelling that is sure and true, and it marks her a write to watch."
"To say this is a terrific debut novel is really too mild. I haven't read such a relentlessly creepy family saga since John Farris's All Heads Turn as the Hunt Goes By, and that was thirty years ago, give or take. Sharp Objects isn't one of those scare-and-retreat books; its effect is cumulative. I found myself dreading the last thirty pages or so but was helpless to stop turning them. Then, after the lights were out, the story just stayed there in my head, coiled and hissing, like a snake in a cave. An admirably nasty piece of work, elevated by sharp writing and sharper insights."
"Not often enough, I come across a first novel so superb that it seems to have been written by an experienced author, perhaps with 20 earlier books to his or her credit. I'm extremely excited to discover my first debut blowout this year, a sad, horrifying book called Sharp Objects...[Flynn] is the real deal. Her story, writing and the characters will worm their way uncomfortably beneath your skin...But this is more literary novel than simple mystery, written with anguish and lyricism. It will be short-listed for one or more important awards at the end of the year...Sharp Objects is a 2006 favorite so far. I doubt I'll ever forget it."
"A deeply creepy exploration of small-town Midwestern values and boasts one of the most deliciously dysfunctional families to come along in a while...[Flynn] handles the narrative with confidence and a surprisingly high level of skill...Wind Gap ends up the sort of place you'd never want to visit. But with Sharp Objects, you're in no hurry to leave."
"Brilliant...Powerful, mesmerizing...A stunning, powerful debut from someone who truly has something to say."
"One of the best and most disturbing books I have read in a long time...Flynn never stoops to the gratuitous, and the torment produces haunting characters that hung around my imagination long after I had finished the book. Her skillful blending of old tragedies with new culminated in an 'oh-my-gosh' moment that I never saw coming. This book simply blew me away."
—Kansas City Star
"Don't look here for the unrelenting self-deprecation and the moping over men common chick lit...I promise you'll be thoroughly unnerved at the end."
"First-time novelist Flynn is a natural-born thriller."
—People Style Watch
"A witty, stylish, and compelling debut. A real winner."
"Flynn delivers a great whodunit, replete with hinting details, telling dialogue, dissembling clues. Better yet, she offers appalling, heartbreaking insight into the darkness of her women's lives: the Stepford polish of desperate housewives, the backstabbing viciousness of drug-gobbling, sex-for-favors Mean Girls, the simmering rage bound to boil over. Piercingly effective and genuinely terrifying."
—Kirkus Reviews (starred review)
"Fans of psychological thrillers will welcome narrator/Chicago Daily Post reporter Camille Preaker with open arms...As first-time novelist Flynn expertly divulges in this tale reminiscent of the works of Shirley Jackson, there is much more to discover about Wind Gap and, most of all, about Camille."
"This impressive debut novel is fueled by stylish writing and compelling portraits...In a particularly seductive narrative style, Flynn adopts the cynical, knowing patter of a weary reporter, but it is her portraits of the town's backstabbing, social-climbing, bored, and bitchy females that provoke her sharpest and most entertaining writing. A stylish turn on dark crimes and even darker psyches."
"[A] chilling debut thriller...[Flynn] writes fluidly of smalltown America."
"[Flynn]] offers up a literary thriller that's a doozy...and she does it with wit and grit, a sort of Hitchcock visits Stephen King, with plenty of the former's offstage and often only implied violence, and the latter's sense of pacing and facility with dialogue...This is not a comfortable novel of touchy-feely family fun. Rather, it is a tough tale told with remarkable clarity and dexterity, particularly for a first-time author."
"A tense, irresistable thriller...Flynn's first-person narration is pitch-perfect, but even more impressive is the way she orchestrates the slim novel's onrushing tension toward a heart-stopping climax."
—Seattle Post-Intelligencer
"Darkly original...Flynn expertly ratchets up the suspense...A disturbing yet riveting tale."
"Skillful and disturbing...Flynn writes so well. Sometimes she dips her pen in acid, sometimes she is lyrical, but always she chooses her words deftly...She has an unsparing eye for human imperfection and for the evil that moves among us."
"Using understated, almost stark prose, Flynn paints a jagged, unflinching portrait of the vise-like psychological bonds between women, and how their demons lead to the perpetuation of cruelties upon themselves and others. The end result is an unsettling portrait of how long emotional wounds can last- and how deeply they hurt."
"More in the tradition of Joyce Carol Oates than Agatha Christie, this one will leave readers profoundly disturbed. But from the first line...you know you're in the hands of a talented and accomplished writer."
"[A] breathtaking debut...Written with multiple twists and turns, Sharp Objects is a work of psychological prowess and page-turning thrills."
—Richmond Times
"As suspenseful as the V.C. Andrews books you shared in high school, but much smarter."
"Sharp Objects is one of the freshest debut thrillers to come around in a long while. It's a gripping, substantive story, stripped of cliche, and crafted with great style. The characters are refreshingly real, burdened with psychological issues that enrich the story. And the ending, which I was positive I could predict, is unpredictable. Sharp Objects is, indeed, quite sharp."
—Augusten Burroughs
"Sharp, clean, exciting writing that grabs you from the first page. A real pleasure."
—Kate Atkinson, author of Case Histories and One Good Turn
When we first meet Camille, she is writing a news story about a case of child abuse. Why do you think the author chooses to open the book this way? What do you learn about Camille from her reaction to the story?
"Natalie was buried in the family plot, next to a gravestone that bore her parents' names. I know the wisdom, that no parents should see their child die…But it's the only way to truly keep your child. Kids grow up, they forge more potent allegiances. They find a spouse or a lover. They will not be buried with you. The Keenes, however, will remain the purest form of family. Underground." Macabre but true?
"Outside on the porch I saw a changeling." How do you feel about Amma? Is she a changeling in the traditional sense of the word? Or a chameleon forced to adapt to her unnatural environment?
"When you die, you become perfect. I'd be like Princess Diana. Everyone loves her now." Is Amma right? Does this apply in the world of Wind Gap? In our lives is this also true?
Do you think there is any significance to the letter A in Sharp Objects? Think of Camille's family in particular.
"I'm here. I don't usually feel I am." How has Camille's past shaped her? Do you agree with the shrinks that her "weightlessness" is due to her ignorance of her history?
"'Oh now look what you've done. I'm bleeding.' My mother held up thorn-pricked hands, and trails of deep red began to roll down her wrists." What does this moment tell you about how Camille views her mother? About how Adora views Camille?
How important do you think the outward appearance of the people in Sharp Objects is to their personalities? Ugliness and beauty are themes throughout the book, but are they the key themes? Or do the characters rise above the visual?
"A ring of perfect skin." One on Camille's back, another on her mother's wrist. What significance does this have? How alike are Camille and her mother? In what crucial ways are they different?
"Sometimes I think illness sits inside every woman, waiting for the right moment to bloom." How far do you agree with this? Can you see how Camille has come to think this?
Female violence is a major concern of Sharp Objects. In what ways are Camille, Adora, and Amma each violent? What does the outlet for each woman's acts of violence tell you about her personality?


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text:
octobre 28, 2013 | Gallery
GOODBYE, ROCK'N'ROLL ANIMAL
We had to do it. Lou Reed, founding member, guitarist and singer of the Velvet Underground, passed away yesterday at 71 years old. We don't know the cause of his death but we don't care. It's just such an enormous loss for rock'n'roll music in general. Because Lou Reed was a legend, a living music legend and he will always be. He gave to rock'n'roll a new face with the Velvet Underground in the 60′s. One of the first album involving an other form of art with the artistic direction from Andy Warhol, major figure of pop art.
Lou Reed was a misunderstood artist. It took time for people to assimilate his music. His beautiful album with the Velvet Underground was a commercial disaster when it was released. It was an inspiration for all a generation though, like Sonic Youth.
After a band career, hard to emerge lonely in the musical scene. Fortunately for us, Lou Reed had the chance to work in the 70′s with Bowie, this period was the zenith of his solo work.
Lou Reed was for a lot of people more than a singer or the Velvet's figure, he was a source of inspiration for a generation of musicians and music-lovers.
Par Aliou
2013 BEST NEW ARTISTS
The 2013 most exciting artists presented by BCKSTG: BANKS An LA-based singer, songwriter and musician who has been at the core of the new R&B influence of this 2013 year. Working with producers such as Totally Enormous Extinct Dinosaurs, SOHN, Lil Silva or Jamie Woon, her unique downtempo style and seductive voice will not leave…
Le duo de Baltimore Beach House est de retour avec « Myth ». Cet extrait de leur prochain album annonce la couleur : en l'écoutant, on ne peut que se languir de la sortie du nouvel opus ! Le paysage indie regorge également de groupes talentueux aux drôles de noms, qui brouillent les styles et…
A l'occasion de la Journée Mondiale de la Voix, BCKSTG vous a sélectionné 9 titres qui vous feront vibrer de bas en haut… On commence avec un coup de projecteur sur Kris Menace, de son vrai son vrai nom Christophe Hoeffel, musicien électronique allemand dont la réputation n'est plus à faire; vous ferez le tour…


text:
Following is a list of architects from the country of Spain.

A–M

Vicente Acero (c.1675/1680–1739)
Martín de Aldehuela (1729–1802)
Martín de Andújar Cantos (born 1602)
Juan Bautista Antonelli (1550–1616)
Claudio de Arciniega (c. 1520–1593)
Juan Martín Cermeño (1700-1773)
Alberto Campo Baeza (born 1946)
Jerónimo Balbás (18th century)
José Banús
Francisco Becerra (c. 1545–1605)
Francesc Berenguer i Mestres (1866–1914)
Alonso Berruguete (1488–1561)
Ricardo Bofill (1939–2022)
Jaume Busquets (1904–1968)
Santiago Calatrava (born 1951)
Nerea Calvillo (born 1973)
Félix Candela (1910–1997)
Alonzo Cano (1601–1667)
Jerónimo Cuervo González (1838–1898)
Antoni Bonet Castellana
José Benito de Churriguera (1665–1725)
Josep Antoni Coderch (1913–1984)
Simón de Colonia (died 1511)
Alonso de Covarrubias
Francisco de Cubas
Josep Domènech i Estapà (1858–1917)
Lluís Domènech i Montaner (1850–1923)
Rita Fernández Queimadelos (1911–2008)
Damián Forment (1480–1540)
Justo Gallego Martínez (1925–2021)
Luis de Garrido (born 1960)
Antoni Gaudí (1852–1926)
Rodrigo Gil de Hontañón (1500–1577)
Juan Gil de Hontañón (1480–1526)
Bernardo Giner de los Ríos (1888–1970)
Juan Gómez de Mora (1586–1648)
Vicente Guallart
Juan Guas (c. 1430–1433–c. 1496)
Rafael Guastavino (famous in United States)
Juan de Herrera (1530–1593)
Francisco Herrera the Younger (1622–1655)
Fernando Higueras (1930–2008)
Andrés Jaque (born 1971)
Josep Maria Jujol (1879–1949)
Pedro Machuca (c. 1490–1550)
Manuel Martin Madrid (born 1938)
César Manrique (1919–1992)
Joan Margarit i Consarnau
Jaime Marquet (1710–1782)
Cèsar Martinell i Brunet
Enric Miralles (1955–2000)
Rafael Moneo (born 1937)
Adolfo Moran (born 1953)
Luis Moreno Mansilla (1959–2012)
Berenguer de Montagut
Carlos Morales Quintana

N–Z

Enrique Nieto
Justo Antonio de Olaguibel
Alberto Palacio
Antonio Palacios (1874–1945)
Liliana Palaia Pérez (born 1951)
Carme Pinós
Isidre Puig Boada
Josep Puig i Cadafalch
Salvador Valeri i Pupurull
Diego de Riaño
Pedro de Ribera
Ventura Rodríguez
Maria Rubert de Ventós (born 1956)
Francisco Javier Sáenz de Oiza (1918–2000)
Enric Sagnier
Josep Lluís Sert (1902–1983)
Diego Siloe
Alejandro de la Sota (1913–1996)
Luis Gutiérrez Soto (1890–1977)
Tioda
Juan Bautista de Toledo
Manuel Tolsá
Narciso Tomé
Eduardo Torroja
Emilio Tuñón
Òscar Tusquets
Andrés de Vandelvira
Lorenzo Vázquez de Segovia
Luis de Vega
Luis Vidal
Juan Bautista Villalpando
Juan de Villanueva
Alejandro Zaera (born 1963)
Secundino Zuazo (1887–1971)

See also

 Architecture of Spain
 List of architects
 List of Spaniards

Spain
Architects


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