Our Repat blanket is buttersoft to the touch thanks to all of the processing (wear) we meticulously put into the shirts over the years, and quite warm considering is is double layered cotton. Repat is now offering baby blankets, a great way to memorialize your little one's first years; and would make a wonderful gift for any college student. In truth, I could see limitless cases where a custom T-Shirt blanket would make a very meaningful gift, and the eco-friendly, American made, initiative behind the company is simply the icing on the cake. If you are looking for a one of a kind family heirloom or gift this holiday season look no further- place your order today and enjoy an exclusive (and generous) 10% discount with code: mommatoldme.
One Momma Told Me reader will have the privilege of putting together their own 5' x 6' T-Shirt Blanket from Project REPAT. Please be sure to check out the Event Giveaway LINKY for ALL the Christmas Wishes giveaways!
I would turn my daughter's tees into a blanket. She collects a tee from each regatta that her rowing team enters -- so we have a lot! It would be so cool on her bed when she goes off to college! GREAT giveaway!
I would turn my brother brett into one!
I'd use my t-shirts for the blanket.
This would be perfect for my daughter's tees. She has TONS with lots of memories attached.
I would use tee shirts from all three of my grandchildren.
I have been keeping some sports shirts of my son's for some time and planning to make a quilt for him myself. But, this would be great to win instead! Ha ha So it would be for my son!
I would use my own tshirts for the blanket.
I would turn our old concert t-shirts & t-shirts from places we've visited!
I'd use my concert tees - I still have a ton!
I would gather my father's brewery t-shirts for this, or I might use my renaissance fest ones. Really not sure.
I would let my daughter pick her favorite tees--probably superheroes and kitties.
Oh I owuld love to turn my sons tshirts into a blanket! So neat!
I think I would use a little bit of mine and hubby's to make a blanket!
I would use my daughter's tees.
My husband has some really great T-shirts. Lots of one liners and TV show icons.


text:
Anelka: Misunderstood () is a 2020 British-French documentary sports film directed by Éric Hannezo and features interviews with Nicolas Anelka, Franck Nataf, Omar Sy, Arsène Wenger, Thierry Henry, Didier Drogba, and Emmanuel Petit.

Release
Anelka: Misunderstood was released on Netflix on 5 August 2020.

References

External links

2020 documentary films
2020 films
2020s sports films
Documentary films about association football
Documentary films about sportspeople
2020s French-language films
Netflix original documentary films
2020s English-language films
2020 multilingual films

redpajama_set_name: RedPajamaWikipedia


Thank you so much for the great article and picture of wonderful Fiona, of Fiona's Boutique in Montrose ["Blame it all on Ragtime the cat," Jan. 12].
She is gentle, kind and visiting her wonderful shop is like stepping back in time. My sisters even come from San Francisco to visit her.
Fiona is a legend and an icon and what's even better, her shop is fantastic. Thank you so much on the feature article about her. She deserves it.


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Mahis (, alternatively spelled Mahas) is a town in the Balqa Governorate northwest from the governorate's capital Salt, and  west of Amman. Its population was 17,754 in 2015. Most of the population of Mahis descends from the Abbadi tribe. (). The mountainous town is located at over , with views on the Jordan Valley, West Bank with Jerusalem's walls visible on the horizon. Mahis is known for its orchards and its numerous water fountains and springs, notably the Fountain of Mahis.

History
Mahis is believed to emerged during the Roman period, when it bordered Jewish Perea and the territory of Philadelphia - Amman of the Decapolis, and in the Byzantine period between the territory of the dioceses of Gadara and Philadelphia. The name comes from the Arabic word () meaning to check out and examine due to its status as a border check point.

In 1838  Mahis was noted located  south  of Al-Salt, and as being in ruins.

The village was listed in the 1915 Ottoman census for the district of Salt as Mahis and the tribe of Jabara and had a population of 505.

The Jordanian census of 1961 found 1,154 inhabitants in Mahis.

By the early 1980s, the town became a practical suburb of the capital Amman.

Religious importance
In Mahis there is a shrine of Khidr, a single room surrounded by a small garden with a green flag on top. Near Mahies (2 km West of Mahis) in an area called Wadi Shuaib, is the grave of prophet Shuaib, or Jethro in the biblical tradition.

Economy
Mahis is based on an agrarian economy, including wheat, barley, and tobacco as well as pomegranates, grapes and olives.  The importance of agriculture is decreasing, though figs and olives are still a primary source of income. The area also produces natural goods such as kaolin which is then produced in the neighboring city Fuhais.
The southern part of the Mahis territory called Almeda also attracts tourism due to its forested mountains and location near the Dead Sea/West Bank as well as Amman.  Mahis also focuses on education and is well known for its higher education academic disciplines.

Demographics
In the 2015 Jordanian census Mahis had 3,284 households for a total population of 17,754, of whom 47.6% were females and 52.4% were males. The inhabitants largely descend from the Jabara (Jubarah) section of the Abbad tribal confederation.

Gallery

References

Bibliography

External links
Mahis website
Photos of Mahes at the American Center of Research

Populated places in Balqa Governorate


UK company based in the north east of England specialising in the design and development of new innovative medical devices. The company is looking for commercial opportunities where they can use their expertise to design and develop innovative new products for the health care market. The company are looking to expand their client base into the European market and are offering a manufacturing agreement or services agreement.
The company specialises in the provision of innovative products and process improvements to the National Health Service (NHS) and wider care industry. The business is a joint venture between a highly innovative award winning SME, a large NHS Foundation Trust and a private company which is also based in the north east of England and who are a world leading design and manufacturing company. Such a unique partnership is highly beneficial as it provides an ideal platform to capture new ideas and the skills of internal NHS resources, to ultimately improve patient care whilst driving efficiencies and reducing costs. The company's innovation may be driven by a specific need, or a bright idea from colleagues within a number of NHS Trusts or wider networks. The company operates as a funnel for innovation, both collating ideas from professionals within the NHS to solve challenges and improve patient care and also creating innovation directly to produce prototypes for improved and novel/unique products. Having unprecedented support and access to the NHS needs and issues is valuable in the development of such products. The company's ideas come from the heart of the NHS and are designed to deliver measurable improvements to patient comfort and safety. By listening to clinicians, catering teams and other professionals, the company can develop quality solutions. These solutions are designed and created with the utmost care and are tested by the people who work within the hospital environment. They are uniquely formed using continuous design input by the people who need and use them most. The current business model of the company feeds revenue back into the NHS to enable further investment into developing innovative new products and processes to help improve the care and safety of patients. The company has unprecedented access to highly skilled NHS resource which is utilised during the project development phase, and also during trials and testing within the NHS environment. The company is uniquely positioned within the medical device design industry. Previous project example to demonstrate capabilities: Beverage Trolley The company aren't the first business to produce a beverage trolley – but first to bring an award- winning solution to the NHS that ticks all the boxes on their wish list. The company developed a new beverage trolley with the staff at a local hospital to improve efficiency for the NHS, reduce purchase costs and also to make sure drinks can be served hot constantly, to avoid any customer complaints. The trolleys have been in use in this hospital since 2012. The trolley meets all infection control requirements and customers can add their own designs to the printed panels which can be changed in seconds to accommodate sponsor or seasonal messages. The trolleys are being manufactured by a world class manufacturer, at its factory in the north east of England. The new trolley has attracted enquiries from the wider NHS and other sectors and the company is now capturing this commercial opportunity, with the first batch of trolleys currently in production. The company is seeking new European partners and is offering a manufacturing or services agreement to businesses who require the skills and expertise offered to support the design, development and manufacture of new innovative products for the health care market. The company is offering its expertise to medical device manufacturers and health care providers to design and develop innovative solutions to their specific requirements.
Type of partner sought - Private or public sector, academic or research organisation. Specific area of activity - Healthcare device design, healthcare provider. Tasks to be performed - Investigate manufacturing / services agreements for design, development and manufacture of new healthcare products.


text:
Bemidji municipal liquor stores rank 4th for net profit in Minnesota
BEMIDJI - The city of Bemidji's two off-sale liquor stores lead most of the state in net profits and racked up more than $5.3 million in gross sales revenue during 2013, according to data released Tuesday by the Minnesota Auditor's office.
However, with expenses factored in, the $5.3 million figure translated to about $1.54 million in gross profit and $831,434 in net profit.
The statistics were part of an annual report compiled by the state of financial data from all of Minnesota's 237 liquor stores that were operational in 2013. To see the report, visit www.auditor.state.mn.us .
The Bemidji liquor stores ranked fourth in the state for net profit out of all municipal liquor retailers. Only the tiny towns of Wilmont (population 340), Ogema (190) and the small city of Grand Marais (1,359) came out ahead of Bemidji.
Bemidji's success comes amid data that show a marginally rougher year for liquor stores' net profits statewide. Overall, net profits for municipal liquor stores went down slightly, $500,522 (about 1.8 percent), from 2012. Additionally, 33 cities reported a net loss for 2013, compared to 25 cities in 2012.
However, a bright spot in the data showed Minnesota cities broke their record for liquor sales revenue overall for the 18th straight year.
Bemidji Mayor Rita Albrecht has said the liquor store profits are used to reduce property taxes, pay for park and trail capital improvements and subsidize street improvement projects.

redpajama_set_name: RedPajamaCommonCrawl


text:
Αποκτήστε το εκτυπωμένο βιβλίο
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Flight Performance of Fixed and Rotary Wing Aircraft
Antonio Filippone
Butterworth-Heinemann, 2006 - 565 σελίδες
Calculation and optimisation of flight performance is required to design or select new aircraft, efficiently operate existing aircraft, and upgrade aircraft. It provides critical data for aircraft certification, accident investigation, fleet management, flight regulations and safety.
This book presents an unrivalled range of advanced flight performance models for both transport and military aircraft, including the unconventional ends of the envelopes.
Topics covered include the numerical solution of supersonic acceleration, transient roll, optimal climb of propeller aircraft, propeller performance, long-range flight with en-route stop, fuel planning, zero-gravity flight in the atmosphere, VSTOL operations, ski jump from aircraft carrier, optimal flight paths at subsonic and supersonic speed, range-payload analysis of fixed- and rotary wing aircraft, performance of tandem helicopters, lower-bound noise estimation, sonic boom, and more.
This book will be a valuable text for undergraduate and post-graduate level students of aerospace engineering. It will also be an essential reference and resource for practicing aircraft engineers, aircraft operations managers and organizations handling air traffic control, flight and flying regulations, standards, safety, environment, and the complex financial aspects of flying aircraft.
· Unique coverage of fixed and rotary wing aircraft in a unified manner, including optimisation, emissions control and regulation.
· Ideal for students, aeronautical engineering capstone projects, and for widespread professional reference in the aerospace industry.
· Comprehensive coverage of computer-based solution of aerospace engineering problems; the critical analysis of performance data; and case studies from real world engineering experience.
· Supported by end of chapter exercises, an extensive Instructor's Manual and downloadable flight performance modelling code.
Περιορισμένη προεπισκόπηση - 2006
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Σχετικά με τον συγγραφέα (2006)
Dr. Antonio Filippone is a faculty member in the Department of Mechanical, Aerospace and Civil Engineering at the University of Manchester, United Kingdom.
Τίτλος Flight Performance of Fixed and Rotary Wing Aircraft
AIAA education series
Elsevier aerospace engineering series
Συγγραφέας Antonio Filippone
Έκδοση εικονογραφημένη
Εκδότης Butterworth-Heinemann, 2006
Μέγεθος 565 σελίδες


This entry was posted on Saturday, May 19th, 2012 at 11:20 am and is filed under The Batman. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.


The Holiday season brings TV stations multitude of Christmas Marathon's. Whether it was the Elf Marathon on USA, the Christmas Story on TBS or the Polar Express on AMC, you would see these movies at an alarming rate. It got me thinking, is there a show or a movie that I could just sit down and watch over and over. The answer is Seinfeld. I know there are multiple episodes played back to back, but never for 24 hours straight. They could dedicate a whole channel to Seinfeld and I would subscribe.
There has never been a show that created pop culture like Seinfeld. Who would have thought a show about nothing would have lasted so long and created such a stir. But if you truly think about it, the best stories in one's life usually come about when something totally irrelevant was going on. There have been many times when just sitting around with my friends we have made up words, called people by a specific feature that makes us remember them. I used to literally run into a convenience store and quickly get what I went in for when I saw an elderly person go in because I knew they were there for Lottery and that purchase would simply just slow my entire day down. That's why I relate to Seinfeld so much.
There have just been so many episodes and terminology that have come up in conversations and have been part of everyday culture. For example, how many times have you been telling a story and to rush the story along said "Yadda, Yadda, Yadda" and made your point. If there is someone that is so strict and militaristic you refer to them as the (Insert activity) Nazi. If you don't want to give something to someone how many times have you said "No Soup for you!!!" Or the ever popular shrinkage reference when you have come out of a pool or a cold shower. I always say "giddy up" when I am on board with a plan or event.
But it is not just the vernacular that makes the show a reference point in conversations. They are some pretty good episodes that were just flat out funny. When my wife and I were getting married and picking out invitations I couldn't help myself but ask about the glue on the envelope. Although that episode ended in death of a character, it is just one of those culture references that I speak about. I can't look at Marble Rye bread without recounting the episode of when Jerry robbed his parent's neighbor in Florida for the loaf of bread. The Hamptons brought some laughs to show. That is where the term "shrinkage" was born. That was also the episode where the cast could not tell their friends that their baby was ugly, and when Kramer found a crate full of Lobsters. A separate episode had George bringing the parents of his dead fiancée' out to his house in the Hamptons, even though they knew he did not have a house out there.
There are just so many things about Seinfeld that always pop in everyday conversations. I did not like the movie "The English Patient" and laugh every time I watch that episode. Every time I have large salad I can't help but point out that I had the "Big Salad" and every time I park in a garage I always make it a point to know where I parked so I don't spend the afternoon looking for my car.


text:
Q: Deploying a Rails App. and user installation So I'm working on a blogging system and I'm just wondering if there's an easy way for someone to deploy it there server and configure the installation.
What I mean by that is to allow them to select the database name, user and password as well as creating an admin account. Much like how Wordpress does it.

redpajama_set_name: RedPajamaStackExchange


The scenario is this: A new member has joined an organization or social group that has a small archive of conversations among its members. He starts to listen, looking for any information that can help him better understand, participate in, enjoy, find friends in, and succeed in this group. As he listens to the archive (perhaps at random, perhaps based on some social tags, perhaps based on an initial keyword search) he finds something of interest, and wants to find more like it, across the entire archive. He marks what he found as a region of interest and requests more like it. The system comes back with a set of ``jump-in'' points, places in the archive to which he could jump and start listening/watching with the expectation of finding something similar.
In the task, the input to the systems will be a 1-10 second audio/video region of interest, and the desired output an ordered list of regions similar to it, matching as closely as possible the judgments of human searchers.
This task of interest to researchers in the areas of speech technology, dialog, and topic modeling.
Participants will receive a 2-hour collection of dyadic English-language conversations, each 5-10 minutes in length, by members of semi-cohesive group. These will include video, two-microphone stereo audio, speech recognition transcripts and a small set of prosodic features computed every 10 milliseconds. Metadata will include the native languages of the speakers. There will be several dozen similarity sets, each containing 5-40 regions, each about 3-20 seconds long, which were judged by one of the user population to all be similar in some way.
The test set will be a smaller set of conversations and a set of regions of interest, or seeds. For each seed, a system will return a list of jump-in points for its inferred similar-region set.
The ground truth is created manually and provided by the task organizers.
The Nature of Search Needs, section 3 of Thirty-Two Sample Audio Search Tasks. UTEP Technical Report UTEP-CS-12-39, Nigel G. Ward and Steven D. Werner, 2012; and the references therein.
Spoken content retrieval: A survey of techniques and technologies. Martha Larson and Gareth J. F. Jones. Foundations and Trends in Information Retrieval, vol. 5, no. 4-5, pp. 235-422, 2012.


We are very excited to announce that Atsushi will offer the Sashiko Stitching Workshop at the "Making Space", which is operated by a well-known Fashion Brand, Eileen Fisher. Yes. This is an announcement of Eileen Fisher x Sashiko Workshop by Atsushi Futatsuya.
The participants will learn all the basic to enjoy Sashiko Stitching and will be able to use some Eileen Fisher Fabric swatches to enjoy Sashiko on. The participants may bring their own Eileen Fisher Garments to add Sashiko stitching or Sashiko Stitched Swatch on.
The concept of Making Space is to create a community where people can gather. It is my honor to be part of this movement, and we sincerely appreciate the generosity of Eileen Fisher to let me offer the workshop with the reasonable pricing. It will be a great opportunity for you to learn Sashiko, in a beautiful location in Brooklyn, with surrounded by their beautiful products.
*Please refer to the blog post to understand what Sashiko is.
Please purchase the ticket through their "Making Space Eventbrite" Page.
Reuse the Garment. Synchronize the Sashiko we respect.
After I received an invitation to offer the Sashiko Workshop at Making Space, I studied about Eileen Fisher as a Fashion Brand. Well, as a male from Japan, I didn't know of Eileen Fisher before. The first message I learned from their website is "to Care", in which I value the most in a process of sharing the culture of Sashiko.
Sashiko was originally developed in a survival purpose. They had to use the needle and thread to survive through the severe winter. In modern society, in the developed countries, almost no one need to use the needle and thread to survive the winter. In fact, the social issue rises from the other side of mending: wasting.
The reason Keiko and I started a project called Sashi.Co is to "bring a life back to the beautiful yet not-used Japanese (vintage) fabric." By doing Sashiko stitching, the vintage fabric gets stronger and more durable with interesting patterns. Patchworking (=connecting) these unique individual vintage fabric give the fabric another life. Keiko tells fabric, "We will bring you back to the main stage, again." We define the main stage as the "ordinary days". The stage we have in our mind is not a fashion stage with many spotlights. It is merely an ordinary day where a person can wear.
Resuing the garment to produce something new.
Using the needle and thread, making Sashiko stitching to repurpose the garment.
Upcycling what we already have with appreciation.
I am happy that I can offer what I am proud of (Sashiko) in such a great space.
More information Coming. More stories I would like to tell.
When I started my own Sashiko project, Upcycle Stitches, I had a great opportunity to talk to the students at FIT. Since I wasn't ready to face to the future fashion stars, I probably gave them strange answers, which probably include some of the disappointment. Well… I wasn't really ready to share my opinion about the fashion waste and potential pollution. It was (and probably still is) too big to answer.
However, I met many people who "Care" as I do.
It is another reason I started our Youtube Channel to share what we do. The event of "Eileen Fisher x Sashiko Workshop" is a beginning of another journey to me. I will study more about their concepts, and I will connect and synchronize what we believe in. More stories are coming up. The "Eileen Fisher x Sashiko Workshop" continues.
Thank you very much for being a part of a great evening, Japan Society NYC x Sashiko Workshop by Atsushi Futatsuya. It is our very first challenge to share Sashiko stitching to so many people. We usually have a workshop for the size of 6 to 12 participants… so yes, it was something great for me. I hope you had received a message for my passion of Sashiko, and introductory technique of beautiful Sashiko stitching.
For those who signed up with your email for the follow-up email, please expect to receive the email from Atsushi by 10/5. If you do not receive anything from Atsushi, the email may be in your spam box, or I misread the email itself. In that case, please contact me from here.
Missed Japan Society NYC x Sashiko Workshop ?
I have received several emails that they, unfortunately, couldn't participate in this Japan Society NYC x Sashiko Workshop.
Do not worry. With increasing of the demand, I am planning to have another Online Sashiko Workshop (Core & Basic) as well as creating a downloadable video of "how to make Sashiko Coaster" which I covered in this Sashiko Workshop at Japan Society NYC.
In order to accomplish my goal, I still feel that "On Live Workshop" is a necessary step to teach how to do Sashiko with the specific thimble and the Sashiko needle. I understand that the needs for "Video – which you can watch and learn anytime" is huge. However, the key to learning the appropriate posture is me continuously checking (not judging) your posture and position of needle and thimble.
If you are interested in this Live – Small grouped Online Workshop, please fill out the form below. Once I find the similar preference and request, I will contact you to set up the workshop.
I hope I delivered this message in the workshop: There is no such a thing as Right Sashiko and Wrong Sashiko. Meanwhile, I make another video of how to make the coaster, and/or how to do Sashiko, please watch other "Live Streaming" and previous Tutorials on our Youtube Channel. Try to learn what you would like to learn. It is not a rule or regulations you need to follow. I simply share the technique and concept which may enrich your Sashiko experience.
Upcycle Stitches LLC offers "Sashiko Stitching Workshop (Core & Basic)" with collaborating to respected organizations which share the similar concepts and values. Since "introducing Sashiko" is my current goal, most of the workshop I offer in 2018 are the basic and core workshop.
In Sashiko Stitching Workshop (Core & Basic), I cover the similar materials to the introductory workshop at Japan Society.
The biggest difference is that I will make sure that the participant "get comfortable to" the running stitch including how to hold the needle, fabric, and using the thimble. I will stand next to the participant, touch her/his hands if necessary, reposition the hands and posture. I will not give up even the participant gives up. From my experience, it takes about 2~3 hours to get used to the Sashiko running stitch.
If you aren't 100% sure how to use the thimble and needle, these basic & core workshops should be a great workshop to make sure what you have learned. The class size is about 6 to 9. A lot of individual attention for every participant in the workshop.
Sashiko running stitch with rhythm.
Difference between Sashik0 and Boro | which I covered a bit in Japan Society Workshop.
How to stitch different patterns | brief explanation.
Unlimited questions within 4 hours and you will get enough answers because of the class size of 9 maximum.
If the participant is comfortable with using thimble and needle as I instructed at the introductory workshop, I can accept him/her for the advanced workshop AFTER checking his/her stitching over the video. Please send me a video of stitching so I can decide if you follow the instruction. However, unfortunately, without my permission after watching the video, the "introductory workshop" will not satisfy the prerequisite to the other (advanced) workshop I offer. It is simply because I need to make sure that everyone is comfortable and understood how to use them when I do advanced workshops. I cannot confirm it in the introductory workshop because of the class size, so the person would need to show me if they got the information appropriately and practice it, or need to take the basic & core workshop to "master" the Sashiko Stitching.
I hope the explanation above is clear for the future Sashiko Workshops.
In 2018, I offer Sashiko Workshops in different locations by collaborating with honorable organizations and groups of beautiful people. If you have taken one of Atsushi's Sashiko Workshops (Full Length of more than 3 hours – maybe named Core, Basic, and/or traditional), and have not received an email for the Sashiko Follow Up within 5 business days, please contact me from here. I will send you the Sashiko Follow Up email with many follow up materials accordingly.
If you haven't received any emails within a few business days after the workshop, something went wrong on my side like a typo in the email address in such. For those who take the workshop in TriBeCa, organized and programmed by Upcycle Stitches, you should get the "Sashiko Follow Up email" the next day (or even the same day).
Thank you for coming to the Sashiko Workshop!
The follow-up email consists of very useful information including one-time free shipping coupon. I want you to be informed. So please do not miss the opportunity if you have taken our full-length Sashiko Workshop.
If you are a graduate of "introductory Sashiko Workshop" like the one I offered at the Japan Society in September 2018, you will also receive the same follow-up emails with follow-up materials. However, please be advised that the these introductory Sashiko workshop will not fulfill the prerequisite for our advanced Workshops. We offer & run our advanced workshops based on the fact that every participant is capable of using the round-shape thimble and the Sashiko long needle.
To learn (master) more of Sashiko stitching, please consider taking in our full-length Sashiko Workshop.
Alternatively, you can send me a video of your Sashiko stitching so I may give you the qualification (fulfillment of prerequisite) prior to the other workshops. Please refer to this blog post to understand the difference between the Full-Time Sashiko Workshop & Introductory Sashiko WOrkshop.
As I mentioned in the workshop, my goal is to keep encouraging you to continue this enjoyable journey. A Sashiko follow up email is a great introduction & summary of what we had shared. I would love to be connected with you who learned not only the technique of Sashiko but also the appreciative culture behind it.
Keep in touch, and let me know if there is anything we can do for your Sashiko life.
Please share photos of your Sashiko accomplishment over the email. I would love to share the alumni's work online so the new learner will learn what they can expect. Also, if you have photos from the workshop, please share them with me, too. As you may have noticed, I barely stop moving during the workshop. I always try to take photos and end up with forgetting about it. It would be very appreciated if you could share your good memory with me as well as the others who are interested in Sashiko.
It would be lovely to see you again, somewhere in the world, or simply online. I have an Instagram account and Youtube Channel, which both share some live-streaming. It is our sincere hope that you will continue the Sashiko stitching, or apply Sashiko stitching to your hand-stitching (hand-sewing) life.
Sashiko Fukin (刺し子ふきん)is one of the most popular Sashiko items in Japan. Fukin means a sampler or a dish-cloth. The Japanese use this square piece of white cloth to cover the food, wipe the dishes, and other many kitchen activities. Here is a sample of How to Sashiko Asanoha Fukin with video of me stitching and the photos of each step. There is no "right" way to proceed the stitching. It is merely a sample but would be useful when you work on the Sashiko Stitching with Asano-ha pattern.
Sarashi (晒)is a Japanese thin cotton fabric. (I plan to have them in stock soon).
We prefer to make Sashiko with the double layers. After drawing (transferring) the pattern, secure the two layers with safety pins or such.
The core concept of making a good Sashiko Fukin is to have the "one-stroke" stitching. The optimal (the most efficient) way to stitch vary from a pattern to pattern.
Stitch around the corner. Then, the safety pins can be removed.
Find the longest line, which happens to be the diagonal lines. Enjoy running stitch without cutting the thread until the thread runs out.
After enjoying the long diagonal lines, then move to the small zigzag lines.
Fill the leftovers with using Kasane.
However, I decided to continue the process by adding another color to make the double stitches to enjoy the difference between dark Indigo & Light Indigo.
Sashiko is a process of simple stitching. However, without proper basics, it could be confusing and difficult to enjoy. Upcycle Stitches LLC & Atsushi offer the Sashiko Workshop in NYC and Online. Please consider joining our community where you can learn not only how to stitch these beautiful Japanese geometric pattern but also connect to a community where people share the same great passion to Sashiko.
Some of the tutorials are available online, Youtube.
I had the month of August as a "Workshop Free month" to focus on my Sashiko Projects. It was a very good opportunity and now it is about time to start another series of Sashiko Workshops. Here is a quick update of Sashiko Workshops September 2018.
Although I was about to advertise on this website before they are sold out, some of the workshops are already full, and some even have a waiting list. I feel very fortunate to have many people interested in Sashiko. I am looking forward to meeting you there, at each location.
I offer the Sashiko Stitching workshop as the part of NJMQG workshop program. It was designed mostly for the member of NJMQG, and all the seats are sold out. If you are a part of Quilt Guild or other organization interested in Sashiko, please contact me for the "custom-adjusted yet traditional" workshop opportunity.
You may find the sample fee and structures on this blog post.
I offer the well-organized Sashiko Workshop at the beautiful crafting store in Soho neighborhood.
Also, check the beautiful thread that Sashi.Co & Keiko Futatsuya exclusively dyed for them with Indigo.
Our goal is to share the beautiful culture of Sashiko. Yes, ideally, I would need at least 3 hours to teach you the technique to enjoy Sashiko as much as we do, I am very happy to share the introductory Sashiko and its culture to the many people who are related to Japan Society NYC, which has been a symbol of mutual understandings between the USA and Japan.
It is my honor to serve as a teacher to share some of the Japanese cultures.
The last, but not the least workshop I have in September is with Tatter Blue Library. In this workshop, we focus on the Sashiko Stitching on the Denim. In the morning section, the participant will learn the basic and core of Sashiko Stitching. After a quick break, we all will work on the denim pants or jackets the participants bring.
It is strongly recommended to participate in both workshops in one day. 7 hours of intensive stitching experience will level you up to enjoy the Sashiko Denim Stitching on your own garment. Would you like to make a denim like a photo below? It is the workshop for you.
*The "Sashiko on Denim Workshop" has a prerequisite of "Traditional Sashiko Workshop" or Sashiko Stitching Workshop (Core & Basic) offered fully by Atsushi Futatsuya.
Even after Sashiko Workshops September 2018, the workshop in 2018 continues. We are working on scheduling one Sashiko Workshop in October (Probably 10/13 & 10/14) in Brooklyn. One weekend of Sashiko Stitching Workshop (Core & Basic) in TriBeCa, NYC, November 17th and 18th.
Once we know the detail, we will introduce it first on Instagram, then a newsletter, then a blog post. Please follow our SNS account and subscribe the newsletter from the sidebar.
I am looking forward to meeting & seeing you!
I am happy to continue this journey of making the Video Log with Sashiko Stories. Here is Sashiko Video Log Story Vol 2 | I am talking about the Difference Sashiko and Boro.
Below, you can find the script I used for this video. Please leave your comment if you have any questions.
The word of Boro became so famous among those who enjoy Japanese vintage fabrics in the last few years. Some art dealers found the beauty of Sashiko, and it is getting the name value on them. The authentic Japanese Boro, especially the large pieces, acquired many recognitions and frequently got good pricing.
At the same time, hand-stitchers like us enjoy the beauty of Sashiko and Boro as the creators (makers). One of the most frequent questions I get in the Sashiko workshop I offer is today's topic. What is the Boro? What is Sashiko? And What is the difference Sashiko and Boro?
Here, let me share my basic understanding of Sashiko and Boro. Again, since there are no official documents found regarding the definition, it is merely my understanding of the words based on our experience in Sashiko.
Sashiko is a form of stitching, a process of needlework. The Boro is the result of continuous & ultimate repetition of Sashiko.
In other words, Sashiko can be a verb in Japanese. We occasionally say that we "do Sashiko". In contrast, Boro doesn't become a verb in the Japanese language. We do not say that we do Boro. Boro in Japanese originally means merely the piece of torn & dirty fabric.
Does it make sense? It is more like a terminology explanation.
Let me share some of the stories about Boro.
As you may have learned already, Sashiko and Boro are developed in poverty, a poor community in Japan.
One farmer wears a Jacket every day. When it gets a hole or tear, his wife mends the jacket with hand-stitching "so-called Sashiko". They did not have a choice. They had to repair it with the fabric they kept from the past because they didn't have enough money or asset to purchase the new fabric. The man's wife kept repeating the mending throughout his entire life, and when his son is old enough to take over the man's job, the jacket was passed down to the next generation. The result of this repetition became a Boro Jacket, in which you may be able to see in a museum or a gallery.
It was, therefore, purely for the practical purposes for retaining the warmth, protecting the skin from the sun-shine or scratch from farming work and pretty much for surviving.
Because of this "purpose oriented beauty", some people call Boro as the random beauty. It could be true. It is not the same as the patchwork or decorative stitching in which the artist (or creator or stitcher) can choose the materials from a variety of choices.
I respect those who implement the concept of Japanese Sashiko and Boro and make the patchworks looks like that. I also respect those who mend denim or Jacket with a hint of Boro's design. You may wonder if I call them Boro or even authentic Boro?
Well, with the sincere respect, I would call them either "Boro-inspired Art" or "Boro Inspired Mending." Please do not get me wrong. I respect them as much as I respect to the Boro from the past, but there is a bit of difference. It is not right or wrong, or better or worse. They are just a bit different.
So, let me talk about the "Randomness" of Boro.
Is it really at Random? I do not believe so. It is true that they didn't have enough materials to be artistic. They didn't have enough materials to choose from.
However, I feel that they had a pride… or basic human desire to make things more beautiful. The Boro pieces I admire have their emotions, including joy, anger, sadness, and happiness from their ordinary days. Because of this emotion behind the Boro, they look so beautiful and artistic, I believe.
It is our nature to be fashionable and pursue the beauty, even when we are in the severe condition like not being able to get the new fabric.
We, Sashi.Co & Keiko, and also my project, Upcycle Stitches, try to follow the route of this Boro. Interestingly, it is kind of difficult to find the vintage fabric from the same era. It is very similar to the Japanese in the past who couldn't get enough fabric.
When we collect the enough "Boro-to-be-fabric" we try to be as creative as possible. We also try to synchronize our "feeling" to the Japanese who probably did Sashiko as we do now.
Most importantly, we try to "think of" others when we make the Boro. The Boro has a story, and even when we make a piece of Boro, we add the stories to the fabric. The process of stitching, by adding the stories (so-called emotion) to the fabric is called Sashiko, and the result of "caring" someone, including ourselves, is called Boro.
I hope my understanding of Boro and Sashiko help you to understand yours. This is a very big topic to cover. I will come back with other stories to share.


text:
P. C. Sorcar, Young
1950 (age 69–70)
Chitra Devi
Pouroosh, Purnasha
P. C. Sorcar, Young (born 1950) is an Indian magician based in Kolkata, West Bengal, India. He is the third son of Indian magician P. C. Sorcar. He is the winner of the Samurai Crown for the Best Magic Show in Japan, the Golden Dragon for the Best Magic Show in China, and other international awards.[1]
Sorcar started practicing magic at an early age, learning from his father, P. C. Sorcar. He also learned the sitar from Pandit Guru Asit Ganguly, dance from Guru Uday Shankar, and completed his master's degree in mathematics from the University of Calcutta.[2]
In 1982, he composed a ballet on the life of Emperor Ashoka, called Rhythm of 262 BC.[1] In 2013, he obtained permission from the Government of Assam to make the Saraighat Bridge disappear.[2]
Some of his most famous illusions include: X-Ray Eyes, where he performs seemingly impossible mathematical calculations while blindfolded; The Water of India, where a magic jug replenishes itself endlessly; and The Curse of Chemia, where a draped body levitating in the air is revealed to have vanished.[3]
He frequently performs with his son, Pouroosh, known as P. C. Sorcar, Master.[4][5]
^ a b "Biography". P. C. Sorcar Young Official Website. 12 July 2015. Retrieved 12 July 2015.
^ a b "PC Sorcar (Young) wants to make Saraighat Bridge 'vanish'". The Times of India. 26 September 2013. Retrieved 12 July 2015.
^ Abraham, Shruthi (9 May 2013). "Abracadabra!". The Hindu. Retrieved 12 July 2015.
^ Gupta, Parama (12 May 2014). "'Magician's Test is on Stage'". The New Indian Express. Retrieved 12 July 2015.
^ Frederick, Prince (13 May 2012). "Running in the family". The Hindu. Retrieved 12 July 2015.
Notable people of P.C. Sorcar family
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P.C. Sorcar Basanti Devi
P.C. "Manick" Sorcar Shikha Devi P.C. Sorcar, Jr. Jayashree Devi P.C. Sorcar, Young Chitra Devi
Piya Sorcar Payal Sorcar Maneka Sorcar Moubani Sorcar Mumtaz Sorcar P.C. Sorcar, Master Purnasha Sorcar
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I think this is dead-on. The problem with tablets or touchscreen laptops is the arm strain of having to reach out and point all day.
There already are proximity sensors in iPhones. With a front facing camera, the tablet could combine data from the camera and prox sensor to see where you are pointing at (rather than actually touching) and this would be a much easier input mechanism. For instance, just point at the screen and a mouse arrow or cursor follows your finger.
This is "cool" enough for Steve, and could help justify the premium price somewhat, that you know Apple will charge.
I'd bet you're right. No more screen smudges. Maybe it uses the camera to triangulate your actions, be great for sign language. Heck, it could even incorporate Pixel Qi's screen and Amimon's just announced WHDI technology to send uncompressed 1080 to your TV.


A clean 4-0 against Mozambique came as a strong medicine, which was an urge need to keep the Lebanese team head above the water. I am sure that this gave the players a great push to look for the remaining rounds of the Olympiad with great optimism.
Never underestimate your opponent, even if he was low-rated than you. And that was the motto of the Men team. On board one, Fadi, playing with the White pieces, played an ending in dynamic way, even sacrificing the exchange, obtaining 2 raging bishops with the black king in the middle of the board. The resignation of his opponent was reasonable, though the engine recommended a certain line to resist.
Though Tony and Nassim, on board 3 and 4 correspondingly, played in a steady way, not allowing their opponents any chances to untangle their pieces, Amr, playing the King's Indian Defense, reached a normal middle game position. Then after some thought, suddenly, put some fire on the board by sacrificing a piece for couple of pawns. Only a computer can refute this type of sacrifice, but it was a promising one, obtaining as a result 2 passed pawns on the king side. A couple of minutes is too short to find the correct defense.
On the other hand, the Women team was performing very badly. On board 1 against the Canadian team, Maya, playing with the black pieces, opened too early the center, forgetting to put first her king in safe place, a situation where her opponent profited from it to the maximum.
On the second board, Youma, after obtaining a certain advantage in the middle game, blundered, by dropping a knight, which was enough to resign immediately.
On the third board, Danielle reached a very acceptable middle game. Then, after opening the center, her pieces looked lacking coordination. After losing the exchange, she tried to resist by searching for a certain fortress, but in vain.
The only well-played game was on the 4th board, during which Sara played in a steady way, reaching a drawn endgame.
A deserved victory for the Men team.
In the U16 Olympiad, the Lebanese young players lost in the 9th round, by a small margin against their Irish opponents 1.5 – 2.5.
But, in the final round, they beat their Sweden opponent 3-1, achieving a nice finish for their first Olympic experience. Seeded as 38, they finished at the 35th place, a very acceptable one. The gold went to the Russia, the silver to Iran and the bronze to India.
I am sure the Lebanese federation VIPs will look at this in a big optimistic future.


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text:
Eupithecia kibatiata är en fjärilsart som beskrevs av Debauche 1938. Eupithecia kibatiata ingår i släktet Eupithecia och familjen mätare. Inga underarter finns listade i Catalogue of Life.

Källor

Mätare
kibatiata


Picture 2 is where the home is at in the building process as of 4/3 A place where home never seemed more welcoming and life never felt so good, each day begins with a beautiful view and fresh air! Lake Breeze offers riverfront living in a location only minutes from Harrison Bay State Park and VW. Along with a large lot and breath taking views, Lake Breeze offers a pool and cabana. Home is under construction. This home will feature 3 bedrooms, 2.5 baths, bonus room, specialty ceilings, custom cabinets, granite counter tops, Wainscoating pantry, unfinished storage (14x22).


text:
Q: Why I can't re-assign a variable in a for loop in python? Today I find an interesting fact, that I can't re-assign variable in a 'for loop', but why?
Here is my code:
>>> my_list = [1,2,3,4,5]
>>> for i in my_list:
>>>     if i > 3:
>>>        i = 'my_value'
>>> my_list
[1, 2, 3, 4, 5]

A: When you loop over a list with for i in my_list, i isn't bound to a list cell on each iteration. It's bound to the object the list cell referred to. Assigning a new value to i binds i to a new object, but there's no link between i and the list that would cause the list cell to be affected.
An equivalent way to loop over a list would be
for index in range(len(my_list)):
    i = my_list[index]
    whatever_loop_body()

Hopefully, it's clearer in this formulation that i is not an alias for the list cell. (Don't actually loop over lists like this.)

A: Let me guess, you want to have a result like the following
[1, 2, 3, 'my_value', 'my_value']

To do this, you need to do this:
['my value' if i > 3 else i for i in x]

Update
Why your code doesn't work? Because i is not a reference to an object but a primitive value assignment. Python variable reference assignment.
Update 2
If the element of the list is an object rather than a primitive, then it seems that i become a reference to that object.
class A:
    def __init__(self, val):
        self.value = val

my_list = [A(1), A(2),A(3),A(4),A(5)]
for i in my_list:
   if i.value > 3:
       i.value = 'my_value'

print([i.value for i in my_list])
# [1, 2, 3, 'my_value', 'my_value']

Update 3
Please see some of the discussion in the comment below. In python, everything is an object. No primitive.
Ref: For Syntax


In the viral way that oddball news travels these days, I picked this up from Alder Yarrow's great blog Vinography, and he in turn seems to have gotten it from Decanter. Regardless, the story is that some French company has created a wine called Soif du Couer (thirsty heart). A fine bottle of vin, selling for a whopping 3 Euros per; you buy a blue bottle if you're male, a pink bottle if you're female, drink the thing by yourself, then use a code revealed once the bottle's drained to go online and access the wine company's dating site—et voilà! Hundreds of other lonely drunk people, just like you. Yikers.
And a lauch in America is being negotiated even now.


text:
Gromet's PlazaPonyGirl/PetGirl Stories
Pony Zen
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© Copyright 2013 - Jo - Used by permission
Storycodes: FM+/f+; F/f; ponyranch; strip; hooves; bitgag; harness; peircing; branding; ponygirls; stables; cart; tack; lactate; milking; stocks; sex; video; voy; cons; X
Brenda looked down from the balcony. Across the yard a man dressed in overalls and a green plaid shirt led two naked women from the barn. They wore bridles fitted with bits in their mouths. Reins were attached to them. They wore leather harnesses which were fixed to the rails of a cart. And they had hooves, hooves on their hands and feet. The man climbed into the cart, shook the reins, and the women went off at a slow trot.
"Brenda?"
"Mm? Oh sorry."
"I asked if you had any questions."
"I... I'm not sure."
"Well, it's fairly simple, really. Like all Zen traditions, we acknowledge the four noble truths: Life is suffering, we suffer because of our desires, there is freedom from suffering, and there is a path to follow. But unlike most traditions, this is our path. Pony Zen. By removing the ego, if you will, you are reduced to a pure animal nature. Desire fades as you become truly mindful of this nature. Like most Zen centers, we have a combination of meditation, exercise, and work periods. Unlike most, our practice is stripped of all teaching. No sutras, no chanting, no dokusan. I am not a Zen Master. I'm merely an administrator. I don't teach, I simply provide an experience that allows you to find your true nature, whatever that may be."
"All I will say is that you must focus on being mindful. Mindful of the sights, smells, sounds. Mindful of the food and water. Mindful of your pony nature. Mindful of the milk leaving your breasts each day."
"Milk?"
"Yes. Pony may be a bit inaccurate. It's more like a pony/cow mix. A hybrid if you will. If it was pure pony, you would have preconceptions. Likewise if I had said cow. But this way you become a simple, nameless farm animal. As for the milking, you'll be given hormone injections. They, coupled with the automated milking process will induce lactation. We sell the breast milk. It helps support the farm. The hormones also induce a false pregnancy so you'll no longer have your period and you won't have to worry about becoming actually pregnant."
"Mm."
"Any questions?"
"Yes. I think... what is the actual practice schedule?"
"That will become apparent once you join the others. You said you've been on Zen retreats. It's pretty similar. It's better not to start filling your head with rules and schedules. Our practice is stripped bare and is quite simple, almost intuitive. Just follow the others' lead."
"Are you ready to get started?"
"Yes. It's not exactly what I expected. I thought it was going to be a rural, farm-like experience and that the whole pony thing was something of a metaphor... but yes. I've taken leave from my job, already made the arrangements. So, yes, let's do it."
"Do you have the checks?"
Brenda handed the woman an envelope.
"Good. Fifty-two hundred for room and board and the ten thousand escrow. That check will be held and you'll be vested ten percent per month. If you leave before the year is up, the remaining funds will stay with us. Just a little added incentive to help you focus on your practice."
The woman pressed a button on a plastic box on her desk. A moment later there was a soft knock and the door opened. Another woman, barely more than a girl, dressed as the man was, entered. She and the woman could have been a twins except for the age difference. Probably mother and daughter, Brenda thought.
The girl nodded. She raised a bit to Brenda's mouth.
"Open your mouth and stick out your tongue," said the woman.
Brenda did so. There was a clam-shaped clamp in the middle of the bit. The girl squeezed it open then applied it to Brenda's tongue.
"Gaa!"
"We have a rule of silence, both among the ponies and with the staff. It will take some time for you to lose the habit of speech. This training bit will help."
The girl fastened the bridle to Brenda's head, attached a lead, and led Brenda out of the room. They went down the hall, through a door, down a flight of steps into the cellar.
The heavy stone walls and floor gave it a forbidding feel. There wasn't much light and there was a musty smell to it.
The girl hitched the lead to a ring in a post and began removing Brenda's clothes. Suddenly embarrassed, Brenda covered herself, but the girl slapped her hands away.
She took a gray tube sock from the work bench, pressed Brenda's left hand into a fist, tugged on the sock. She picked another, a black one, and it took Brenda a second to realize that this one was rubbery. Once in place, the girl turned on a heat gun and applied it to the plastic. It shrank, forcing her hand into an even tighter fist.
The girl measured Brenda's hand, stepped over to a cabinet, and retrieved a hoof. She slipped it over Brenda's hand, up her forearm, zipped it. If anything it was even more snug. The girl took a pair of pliers and snipped off the metal toggle.
The girl repeated the process on Brenda's right hand, then Brenda's left and right foot.
The sensation was like standing in an impossibly high-heel shoe, but without the heel.
The girl led Brenda, staggering, over to cage of sorts. Clopping echoed off the walls. She guided Brenda between two sets of bars, positioned Brenda's head in an oval opening, pulled a lever, and the bars sprang shut, trapping Brenda in a vice-like grip.
She rummaged around in a box, took out something metallic, and fit it to the nozzle of a gas torch. She lit the torch.
Next she opened what looked like a tackle box, removed a syringe, snapped on a fresh needle, took a small vial from a refrigerator, and filled the hypo. She jabbed Brenda in the ass.
The girl picked up the torch. The tip glowed red. Brenda could see the letters LI. It took a moment for her brain to register that she was seeing it upside down. Another moment for a wave of fear to wash over her. But by then it was too late. There was a searing pain to her hip, the smell of burnt flesh.
"GAAAA!!!!"
Brenda stood, trapped, taking short, gasping breaths. But the girl wasn't done.
She pulled on a pair of latex gloves, took a swab and swabbed Brenda's nostrils with something tart, medicine smelling. She positioned the ends of the forceps in Brenda's nose, clamped them tight. From the same plastic box she took out a needle and a metal ring. She pressed the tip of the needle to Brenda's septum and pushed. Brenda winced, tears ran down her cheeks. Somehow she managed not to scream, but it hurt. Through blurry eyes she watched the girl use two pair of pliers to close the ring.
The girl wiped Brenda's face, released her from the bars, and hitched the lead to the ring on the post. She stepped over to the wall, pressed a button.
"Done."
Brenda stood, shaking, her mind reeling. Her brain was in denial, but she could feel the weight of the metal on her upper lip. When she looked down there was the LI... 17
Oh God.
There was the sound of footsteps, then the woman was there. She examined the brand and the ring.
"Good. Very good. Now, 17, you should be getting a clear picture of what you signed up for. Don't think about it. Don't rationalize it. Don't analyze it. Just go with it mindfully. This is pure Zen, an arrow driving straight to the heart. Except in our case the arrow is a pony."
She unhitched the lead and exited through a heavy wooded door. Brenda followed, still unsteady on her new hooves.
In the barn there were rows of stalls. They appeared empty until Brenda got closer, then she could see a woman in each, kneeling, sitting back on her haunches, fore-hooves on the floor, facing the back of the stall. Each wore a bridle and bit and a set of reins was attached to a ring on the wall.
As they made their way down the row the woman stopped. A pony in stall 6 was crawling backward to the front of the stall. She rose a bit, squatted, and emptied herself, both piss and shit. She assumed a kneeling position with her arms on the floor and her ass in the air. A groom stepped over and shoveled the mess into a bucket. He pulled a moist towelette from a dispenser and wiped her front and rear. He did that three times. The pony then crawled to the back of the stall and resumed her place, kneeling in the straw, facing the wall. The groom hosed down the spot.
The woman led 17 into an empty stall. She cinched 17's reins to the wall, pushed on her shoulder. 17 knelt, then slowly keeled over onto her side.
"The first night is the hardest. The injection was laced with a sedative. Sleep well."
Brenda woke to the sound of metal hooves on stone. Her own hands and feet felt odd. She thought for a moment that she was dreaming, but when she rolled over there was a stabbing pain in her hip. Brenda became instantly awake, if a bit groggy. She looked down. The number 17 burned into her flesh. It wasn't a dream!
A groom came in, led her out of the stall, cinched her reins to the back of another pony's bridle. The groom worked his way down the row of stalls, hitched each pony to the one before. At the front of the line was a cart, a flimsy looking thing, little more than a pair of bicycle wheels and with a board. From the cart two rails extended and two ponies stood between the rails. They each wore a leather harness, their fore hooves were clipped to the harness and the harness to the rails.
Once the twenty ponies had been set it place, the groom climbed onto the bench seat, flicked his whip, and the ponies set out at a trot. They made their way past a paddock, along the edge of the trees. A path veered into the woods and the groom guided the ponies into it. Another flick of the whip and the ponies accelerated to a canter. Deeper into the woods he drove them into an all-out gallop.
By some miracle, 17 managed not only to keep up, but stay on her hooves. While it still felt awkward walking, running felt like it did when she jogged, up on her toes.
Back at the barn the grooms released the ponies one-by-one. One groom hosed them off, a second toweled them dry, a third led them back to their stalls, a forth fitted the milking machine cups.
The groom smeared something on 17's chest, placed the cups into position. They immediately latched on and drew 17's already large teats deep inside. It felt distinctly uncomfortable, 17 thought, but some part of her brain registered the fact that it would be most welcome when her teats were heavy with milk.
After milking they were fed. A fresh bowl of water and a bowl of what looked and smelled like doggie kibble. The groom removed 17's bit. She leaned forward, lapped up some water, nibbled at the brown bits in the bowl. The groom came in. 17 had barely touched the food. He pointed at the bowl, 17 shook her head, he lashed her once, hard, across the back, fitted the bit in her mouth, and removed the bowl.
17 knelt in meditation through the morning. After lunch she received another lash even though she had managed to eat most of her food. Hunger was overcoming distaste. In the afternoon she was led with another pony to gather hay as she'd seen yesterday. Back in her stall her system kicked in and she worked her way to the opening and squatted. The groom cleaned up the mess and wiped her.
17 cleaned her bowl at dinner.
"Thirty days. How's she doing?"
The girl exhaled a plume of blue smoke and handed the joint to her mother.
"Do you mean Web-wise or personally?"
"Personally. Web-wise she's something of a hit."
"The new ones always are. Although, in this case, it's a bit surprising. I mean, she's not much to look at."
"A bridle bit is a great equalizer, cures a multitude of sins."
"So you say. She has a decent body, though. Moves well in her hooves."
"And pairing her with 4 was a good idea. They complement each other."
"Yeah. Personally? She's settled right in. She's cleaning her bowl. Knows how to take a dump. Cooperates with the grooms. Yeah. She's doing okay. Milk production has leveled off. Pretty good actually."
"Okay, time for phase two. Make sure you capture it."
"For Christ sake, Mom, we've got over a hundred frickin' cameras out there. I know my job."
The groom unclamped the bit from 17's tongue. He fit a new bit, one without the clamp. It felt odd to move her tongue, having grown used to the clamp.
He led her down the row of stalls to a door. She had no idea what lay behind. When in the barn she knelt facing the rear wall of her stall with the sounds of hooves clopping throughout the day as the grooms led other ponies here and there. Her world consisted solely of her stall, the farmyard, and the wood path.
The groom led 17 into the room. In the middle was a short, wooden pillory. There was another set of stocks on the floor and a wooden rail separated them. He bent 17 over the rail, lifted a board, and positioned 17's neck and wrists in the slots. He lowered and secured the board. He spread 17's ankles and fastened them wide apart into the lower stocks. As she was, 17 could neither stand, nor bend forward, nor adjust her position in any way, bent nearly double at the waist, ass in the air.
"She was a virgin?"
"Yeah. Who knew?"
"You-"
"Yes, Mom, I got it. I did a split screen edit and got the look on her face as they plowed into her. Even brought in a hand-held to get a shot of Al's bloody cock and the blood and jizz running down her legs."
"Posted it yet?"
"No. Going to play the time zones. I put up a couple of teasers. Plan to update at around ten our time, that'll be seven on the left coast."
"We're not going to have server issues, are we?"
"Uh uh. We can handle the load. But I'll double check just to be sure and I'll babysit while it happens. Probably make a boatload of money. You know, we'd make more if-"
"Don't go there, Kate."
"But we get a lot and I mean a LOT of e-mail."
"Yes, and we get nut jobs asking us to slaughter them and we're not doing that, either. Besides, breeding them isn't all it's cracked up to be. Birth is messy. And, it would cut into our production time."
"Yeah, but pregnant ponies..."
"No. We're already censored in some countries. Now you want to bring children into it? Listen, they're all nicely conditioned into this pony thing. You bring kids into the picture and it'll change the whole dynamic."
"Yeah, yeah, okay."
In her stall 17 knelt. She was mindful of the smell of the straw, of the feel of it beneath her knees. She was mindful of the hoof falls as ponies went about their day. She was mindful of the strange, dull ache between her legs. She was mindful...
If you've enjoyed this story, please write to the author and let them know - they may write more!
ponygirl stories


A scientist couple from the Chinese Academy of Science (CAS) donated their life savings of 1.5 million yuan ($223,000) to the education foundation of the University of Chinese Academy of Sciences on Tuesday to set up a scholarship.
Zheng Ruyong, 88, a well-known mycologist and academician of CAS, and her husband Huang He, 90, a scientist at CAS, set up the Zheng Ruyong and Huang He Scholarship to encourage young people to devote themselves to scientific research.
Zheng has been working at CAS since she graduated from college in 1953. She discovered endophytic mucor in higher plants for the first time in the world. Her research on powdery mildew has reached the world advanced level.
The husband and wife have devoted nearly all their life to scientific research. Zheng has spent more time with a microscope than she has with her husband. They don't have children.
She suffered from bone rarefaction and lumbar disease as a result of working long hours. In 2004, she had two steel rods and nine steel nails inserted in her spine. The doctor told her she could only sit for one hour a day and had to stand or lie down the rest of the time. Zheng elevated her desk and research table and began working standing up.
During 2012 and 2018, Zheng donated 300,000 yuan to Beijing Haiying Spinal Health Foundation to fund poor children suffering from spinal diseases.


Anybody got one? Opinions against a Zuiko 9-18?
Would be around the same price with an adapter as an m.Zuiko 9-18mm - which do we reckon would be most worthwhile?
I've got a Sigma 10-20. I've had it for years and I love it!
Thankfully I seemed to have got a sharp copy. The lens is a pleasure to use and well balance on my E3, infact for the derelict stuff I do it doesn't really leave my camera, well apart from one time when I bust it lol.
I've only used the 9-18 once, its a cracking lens but a little and unbalance on my E3 but thats only imho.
I have one of these, I have achieved some excellent results on my E3 and 520, The wife aslo pinches it off me and uses it with her 510 for landscapes. Have not tried the ZuiKo 9-18 so cannot compare but I think the Sigma does represent good value for money in comparison to the ZuiKo. I agree with Garrie would probably only change it for 7-14 if I could find one at the right price.
I like my 10-20mm too.
I'm currently away from my pc but there is a lot of stuff at my gallery - www.onemileahead.co.uk - under the derelict section (gritty hdr warning) I think all the exif data is present as some sites were shot before I got the sigma!
Once I'm home tomorrow I can post some non tonemapped examples!
A 7-14 would be nice but a tad pricey, plus I like the overlapping focal length at the tele end of the 10-20, would save changing lenses so often.
Garrie there are some cracking shots in there, but I havent been able to view the EXIF info for the ones I've checked, it could just be that I've looked at all teh wrong images mind!
Could anyone comment on it's live view AF?


In support of community engagement efforts, The Calgary Police Service is pleased to introduce The Hub Messaging System, a community automated notification system that delivers vital information to residents and business owners within the City of Calgary.
The Hub Messaging System will utilize sophisticated software by strategically sending information to a selected geographic area made possible through a community member sign-up webpage. Messages will be prepared and delivered by the Calgary Police Service through email, voice, and text messaging. Message types and user delivery profiles can be tailored to meet the needs and preferences for each registered community member. Community members can choose to change their profile or unsubscribe at any time.


I am the Centre Manager and I look after all the activities and the instructors and the grounds. My job is varied as I can be accessing the high poles one minute , to running a campfire, to ensuring all our operating procures are up to date and correct.
I enjoy working with the wide variety of staff that work at Blackwell Adventure. I have met a large number of people from all over the world that have bought so much to Blackwell. I also like Archery!
I am blessed to be a Dad to two beautiful little boys who keep me up at night time, poo a lot but also bring me lots of happiness. I'm a big Liverpool fan and finish every year disappointed.


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Q: Wrong indexing of a string (Python) Something that should be very simple and yet I am not able to solve it.
The indexing does not appear correctly when a character duplicates:
For example:
list=[]
stringg="BAtmAn"
for i in stringg:
    if i.isupper():
        list.append(stringg.index(i))
print(list)

And the output shows [0,1,1] instead of [0,1,4].
When the stringg variable is changed to "BAtmEn" it appears the way I expect it to appear in the first example.

A: The following would do what you want
stringg="BAtmAn"
print([x for x in range(len(stringg)) if stringg[x].isupper()])
print([i for i, c in enumerate(stringg) if c.isupper()])

A: list=[]
stringg="BAtmAn"
for i in range(len(stringg)):
    if stringg[i].isupper():
        list.append(i)
print(list)

should try this...
.index('item') can only find the index of the first of that 'item' in the list.


Read and discover resources filled with advice, ideas, forms, and underlying pedagogical theory that can help you in your teaching.
This section contains information about active learning, lecturing, leading class discussions, cooperative and group learning, using writing assignments, designing research assignments, using case studies, and team teaching.
This section addresses different contexts for teaching: the first day of class, large classes, motivating your students, teaching labs & studio classes, teaching first year students, teaching controversial topics, and working with TAs. It also contains a link to an award-winning interactive resource, "Solve A Teaching Problem."
This section provides links to teaching advice -- resources and methodology -- aimed at specific disciplines. Check these out to get ideas from others in your field.
The concrete suggestions in the other sections is backed up research and pedagogical theory.
These sources discuss the basic building blocks that underlie the practice recommendations.
SMU professors share some ways they engage students in critical thinking.
Listen to podcast In this podcast, Sheri Kunovich highlights how she uses visual sociology projects in her upper level courses by requiring students to go beyond quick observations of social life.
David Son shares an in-class activity called "Think, Pair, Share," that helps promote students' active engagement and provides more opportunities for students to think and engage in the classroom.
Robert Krout shares an assignment from his Survey of Music Psychology course where he challenges students to transfer and apply terms and concepts being learned in class.
Lynn Stokes shares a "Warm Up" assignment from her Introduction to Statistics Course. In this assignment, students discuss statistical concepts without using numbers. This process helps Lynn assess their understanding of the applications discussed in class.
Technology provides numerous tools that teachers can use in and out of the classroom to enhance student learning.
Faculty members should consult SMU's office of Academic Technology Services, which provides many kinds of support, including hands-on training in using classroom technology. (Click here for classroom-specific information about the setup in many campus buildings). SMU's STAR (Student Technology Assistant in Residence) Program is also available to help with short-term instructional technology projects.
There are also numerous on-line resources about using technology to enhance teaching in a number of different ways. For example, Teaching with Technology 2, from the Learning Technology Consortium, offers 17 peer-reviewed essays on using different kinds of educational technology, and the book can be downloaded for free. MERLOT is a huge, peer-reviewed, multi-disciplinary resource for learning and online teaching. Here's a curated list, from About.me to Zotero, of free online tools that you can use in your teaching. Below are links to resources on using specific types of teaching and learning tools.
Sometimes it's helpful to provide visual aids to complement teaching, stimulate discussion, or allow out-of-class teaching. Tools designed for this purpose, such as PowerPoint, can be used well or used badly. Click here for resources that provide advice for thoughtful use of PowerPoint, as well as a few additional presentation tools.
Garr Reynolds, Presentation Zen, What Is Good PowerPoint Design?
One way to encourage student engagement is by using electronic devices that allow students to record their answers to multiple choice questions and allow you to instantly display the results. The anonymity encourages participation, and their answers help the teacher know when further discussion is needed. Use of clickers can also serve as a catalyst for discussion. Click here to learn more about using response systems effectively.
Clickers allow teachers to poll attitudes, check comprehension, stimulate discussion, and more. And everyone loves a toy!
Technology can support student collaboration on creating new knowledge, reflecting on what they are learning, or working together to achieve a deeper understanding of course material. These articles provide ideas about their use and misuse.
Online tools provide many new options. Students can collaborate on projects, collect and synthesize information, and write for different types of audiences. Here are some examples.
Teaching in the Cloud: Using Online Collaboration Tools to Enhance Student Engagement (discusses jointly edited Google Docs, Google Sites, wikis, cloud storage of video projects, crowdsourced research, Google Spreedsheets for data aggregation, Piazza, and class blogs; also considers issues of IT support, ease of use, and student privacy).
Vanderbilt's Center for Teaching provides this helpful overview.
Revisiting Twitter as an Educational Tool (using Twitter to help students engage with each other and with the outside world -- and for your own professional development, from the University of Oregon's teaching center).
Using Xtranormal Against Straw Men (a professor describes assigning students to make Xtranormal videos to demonstrate the ability to realistically grapple with counterarguments).
Technology can also clarify and stimulate thought through transforming words into pictures. Here are some tools to help lead your students to think more critically by encouraging them to visually structure information.
Is a table worth a thousand words? Visualization tools can help you make information clearer to students, either by providing you with clearer visuals or, better yet, assigning them to use visuals to make connections.
46 Tools to Make Infographics in the Classroom (help your students deepen their understanding by showing connections, mapping, creating timelines, etc).
How can we make the best use of the classroom time we have with our students? Sometimes a great way to move them toward higher levels of understanding is to move the lecture out of the classroom, and use in-person time for interactions that require applying, synthesizing, and creating. "Flipping" doesn't have to use technology, but tools such as videos, podcasts, online quizzes and the like can help in and out of class activity work together. These resources explain the theory underlying this teaching method and provide practical suggestions for making it work.
What do you want students to do out of class, and what do you want to do when you're all face-to-face?
Two short videos (here and here) from UT Austin explain and demonstrate the flipped classroom model.
Digital Learning Toolbox provides numerous tips and tools for Flipping Your Class.
Harvard's Eric Mazur, a major proponent of the flipped classroom and peer instruction, explains why in this workshop.
SMU's Jose Bowen, Dean of the Meadows School of the Arts, calls it "Teaching Naked." He explains why it's necessary in this video, and describes it in detail in his new book. His blog also contains a number of resources and ideas.
Whether for a flipped class or just as a resource for your students, you may want to create a podcast that conveys information students need for initial learning or review. SMU's Academic Technology Service can provide instruction on creating podcasts, and will loan you a podcasting kit. These articles discuss how to make and use podcasts effectively.
Maybe you want students to listen to information before they come to class. Maybe you want to make a recording available to them for review. There are many reasons to create podcasts.
What could be more engaging than a good game, used well? These articles discuss why a game may lead to deeper learning and give some examples of their use in higher education.
James Paul McGee (U Wisconsin), Why Are Video Games Good for Learning?
Jane McGonigal, who was a Tate Lecturer in the fall of 2012, even believes that video games can help teach students to solve serious real-world problems. Check out her TED video for inspiration.
SMU's Guildhall, although not specializing in educational games, offers a Masters degree in Game Development.
Thinking about buying a tablet computer that will provide lots of computing power, and also provide lots of teaching options (including lecture capture)?
Check out this review of Windows 8 tablet computers by SMU's own Paul Krueger, co-facilitator of last year's faculty learning community on Teaching with Technology.
Thinking about creating your own tablet-based textbook? Learn more about iBooks Author.
Teach research and group collaboration skills with the Scavenger Hunt with Friends app.
Ideas for using QR code scanners in teaching (those are those little square boxes).
Want to try some in-class use with a small class? The Touch Learning Center in Fondren Library provides technical support, encouragement, moveable desks, 15 iPads, and a 70-inch LED TV monitor.
Teaching online, whether in a hybrid course or a wholly-online course, requires different techniques and different tools. Without the F2F contact, professors will need to be even clearer about setting and articulating expectations for digital work and participation. Encouraging interaction between professor and student and among students is an additional challenge, as is monitoring student learning as the course progresses. The online environment requires the use of basic technologies to digitize course materials as well as mastery of the university's learning management system. And various tools like Skype allow synchronous communications, while blogs and Twitter can encourage asynchronous interaction.
Using course components that are online rather than face-to-face creates both new challenges and new opportunities. Here are a few resources to help start that journey.
University of Central Florida offers a Blended Learning Toolkit, a step-by-step guide to getting started with hybrid/blended courses.


Freestompboxes.org started out in the summer of 2007, when there were heated discussions in other online guitar forums. Forum admins of stompboxbuilder's forums happily catered to the need of commercial builders to have schematics of their unit censored, despite the fact that they did not infringe on the builders copyright in any way. Because of the profound interest of a whole lot of stompbox fanatics to learn what is inside these units, freestompboxes.org tries to provide a free haven discussion on and documentation of guitar effect units.


Power Flame is a major manufacturer of quality linkage-less burner control systems that help your industrial/commercial burners meet the highest attainable performance and environmental standards. ATI can facilitate the purchase of a Power Flame linkage-less control system as well as assist you in selecting the system that is optimally efficient for your specific application.
Why Use Linkage-less Burner Controls?
A linkage-less control system, especially when combined with an exhaust gas analyzer, can help you reduce energy waste and NOx and other harmful emissions. It can also ensure complete combustion, high turn-down rates, minimal excess air levels, and full "repeatability." Linkage-less controls use a microprocessor to monitor boiler target temperatures/pressures and then trigger responses to continually maintain optimal temperatures. The end-result is your burner runs safer, more efficiently, and with less harmful exhaust gas.
Mechanical burner controls, which use linkages, cams, and jack-shifts to control fuel-air ratios simply cannot maintain optimal combustion and fuel-efficiency the way that linkage-less systems do. To try to make up for inherent systemic shortcomings, mechanical systems rely on adding extra air (usually around 50% excess), but this solution actually decreases overall efficiency.
Linkage-less controls avoid the inefficiencies of mechanical controls and conveniently display key burner metrics for individual channels, checking each channel as often as 50 times a second to ensure moment-by-moment accuracy.
Power Flame manufactures a large, diverse linkage-less burner control systems, each of which optimally meets the needs of particular commercial applications.
Power Flame linkage-less controls enable you to closely monitor/control the air-fuel ratio of your burner — and far more precisely than with "conventional" burner control systems. They drastically reduce excess oxygen levels and achieve complete combustion. This, in turn, lowers operating costs and minimizes NOx and other emission gases.
They use Honeywell ControLinks to keep air in parallel with fuel.
They have dual-fuel capability, and separate programming can be used on gas/liquid fuel types.
They use a separate servo to optimize the fuel-gas ratio.
By induction of small amounts of flue-gas, peak temperatures are kept in check, which reduces NOx emissions.
The high efficiency and "earth friendly" features of Power Flame linkage-less control systems are fully programmable.


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Rand Paul Offers To Buy 'Ungrateful' Omar A Ticket Back To Somalia
"Maybe after she's visited Somalia for a while she might come back and appreciate America more"
Steve Watson
Senator Rand Paul weighed in on the furor surrounding Democratic Minnesota Rep. Ilhan Omar, suggesting that if she went back to Somalia for a while she might appreciate America more than she seemingly does now.
"I hear Rep. Omar say, 'Oh, America is a terrible place," Paul said during an interview with Breitbart on Wednesday.
"I thought there'd be justice but there's no justice here. It's like, she came here and we fed her, we clothed her, she got welfare, she got school, she got healthcare, and lo and behold she has the honor of actually winning a seat in Congress and she says we're a terrible country." Paul continued.
"I think that's about as ungrateful as you can get." the Senator urged.
Paul even offered to contribute toward a ticket for Omar to go back to Somalia.
"So while I'm not saying we forcibly send her anywhere, I'm willing to contribute to buy her a ticket to go visit Somalia." Paul noted.
"I think she could look and maybe learn a little about bit about the disaster that is Somalia, that has no capitalism, has no God-given rights guaranteed in a Constitution and has about seven different tribes that have been fighting each other for the last 40 years." he continued.
"And then maybe after she's visited Somalia for a while she might come back and appreciate America more." Paul concluded.
It is the same suggestion made by President Trump earlier this month.
So interesting to see "Progressive" Democrat Congresswomen, who originally came from countries whose governments are a complete and total catastrophe, the worst, most corrupt and inept anywhere in the world (if they even have a functioning government at all), now loudly……
….it is done. These places need your help badly, you can't leave fast enough. I'm sure that Nancy Pelosi would be very happy to quickly work out free travel arrangements!
Of course, anti-Trumpers took the comments out of context and claimed Trump was suggesting deporting Omar.
Some on social media responded by suggesting that it is actually Rand Paul who hates America, because he voted against the bill to provide further financial assistance to the 9/11 First Responders Victims Fund, while Omar voted in favor of it.
In reality, Paul explained in detail why he voted against the bill, sticking to principles that have seen him also vote against funding for the border wall and disaster relief. He also proposed amendments which would have required offsets for money spent on the fund.
While I support our heroic first responders, I can't in good conscience vote for legislation which to my dismay remains unfunded. We have a nearly trillion dollar deficit and $22 trillion in debt. Spending is out of control.
— Senator Rand Paul (@RandPaul) July 23, 2019
As I have done on countless issues, including disaster relief and wall funding, I will always take a stand against borrowing more money to pay for programs rather than setting priorities and cutting waste.
Ilhan Omar, on the other hand, still refuses to condemn Al Qaeda terrorists, and has described the 9/11 attacks as "some people did something."
This article was posted: Friday, July 26, 2019 at 6:42 am


I'm a Research Scientist at DeepMind in London.
I did a PhD in Physics at Princeton University, advised by David Schwab and Bill Bialek, and funded by a Hertz Fellowship and a DOE Computational Science Graduate Fellowship. I did a master's at the University of Cambridge with Mate Lengyel as a Churchill Scholar and studied physics and mathematics at the University of Southern California, where I worked with Bartlett Mel and Paolo Zanardi. During my studies, I also spent time at DeepMind working with Matt Botvinick, Stanford University working with Kwabena Boahen, the Institute for Quantum Computing working with Andrew Childs, and Spotify NYC working with their machine learning team.
I accepted a job at DeepMind beginning in March 2019.
Our paper on promoting generalization and exploration in RL by training agents with information bottlenecks between goal and policy was accepted to ICLR 2019.
I presented our paper on promoting cooperation / competition via information regularization at NeurIPS 2018.
I defended my PhD in August 2018.
I'm interested in reinforcement learning (RL), information theory, and deep learning with an eye toward understanding and creating intelligent agents. Much of my work has focused on the information bottleneck (IB) and lately I've been interested in using IB to improve the training of RL agents. In the past, I've also worked on quantum information theory and computational neuroscience.
We train agents in multi-goal environments with an information bottleneck between their goal and policy. This encourages agents to develop useful "habits" that generalize across goals. We identify the states where agents must deviate from their habits to solve a task as "decision states" and show that they are useful targets for an exploration bonus.
We reward agents for influencing the actions of other agents, and show that this gives rise to better cooperation and more meaningful emergent communication protocols.
We train agents to cooperate / compete by regularizing the reward-relevant information they share with other agents, enabling agents trained alone to nevertheless perform well in a multi-agent setting.
We show how to use the (deterministic) information bottleneck to perform geometric clustering, introducing a novel information-theoretic model selection criterion. We show how this relates to and generalizes k-means and gaussian mixture models (GMMs).
We use the variational deterministic information bottleneck to regularize discrete latent variable models, encouraging the use of as few latent variables as possible for a given level of performance.
We introduce the deterministic information bottleneck (DIB), an alternative formulation of the information bottleneck that uses entropy instead of mutual information to measure compression. This results in a hard clustering algorithm with a built-in preference for using fewer clusters.
We fit neural network models to single neuron data to understand the computational role of dendrites in integrating their synaptic input.
We study the olfactory neural code in mice and find that much of the information about the stimulus is only decodable when interpreting neural activity relative to the sniff phase, providing evidence for the importance of considering sensory sampling behavior when interpreting neural codes.
We study the optimal conditions for online recognition memory in a biologically-inspired neural network with "dendrite-aware" learning rules.
We prove an analog of a classic result in quantum scattering theory for the setting of scattering on graphs. The goal is to provide additional tools for designing quantum algorithms in this setting.


Will fit Canon 350d 400d 450D 1000D 20d 30d 10d 300d 5d. 40D /50D ???
New, in leather pouch, 1x and 2x mag.
Solidly made, rotates 360 degrees.
If it fits the 5D it will certainly fit the 40D. However in my experience (with the Canon angle finder) you need the type S "precision matte" focusing screen for the device to be of any use to help focusing, the standard screen on the 40D is much too coarse for a magnifying angle finder to be effective.
The device's action as a "diagonal", saving neck strain, is fine even with the standard focusing screen.


The Complete Essays 1973–1991, by Luigi Ghirri; edited by Michael Mack and Izabella Scott; translated by Ben Bazalgette and Marguerite Shore. London: MACK, 2016. 239 pages.
In the years after New Hollywood cinematographers popularized lens flare as an acceptable filmic glitch, a certain strain of color photography—as seen on moody LP covers and ad pages for muscle cars or cigarettes—seemed to dwell almost exclusively in the magic hour, that pre-twilight moment when the sun emanates diffraction spikes and gentle melancholy. Roughly the same period marked the apex of utopian design's perfusion in popular culture, as geodesic domes materialized everywhere from Expo 67 in Montreal to Colorado's legendary Drop City commune.


text:
Cobalis
cobalis.com
Bumetanide may benefit only a subset of autistic children
The blood pressure drug bumetanide does not uniformly lessen autism traits in autistic children and teenagers, according to a new clinical trial1.
The results are at odds with past research that suggested the drug eases autism traits in children on the spectrum.
Still, the new study's data hint that bumetanide may help a subset of autistic people with a subset of autism traits. Researchers assessed the drug's effects primarily by using a measure of social ability and saw no improvements, on average. But a secondary analysis suggests that some children who got bumetanide improved in social skills more than those who took a placebo. And on a secondary outcome measure, repetitive behaviors, bumetanide did have a positive effect at the group level.
The study paves the way for future work to identify a biomarker that predicts which autistic children would benefit from bumetanide, says lead researcher Hilgo Bruining, associate professor of psychiatry at Amsterdam University Medical Centre in the Netherlands.
"One-size-fits-all treatment for bumetanide is not a very realistic idea," he says. "We first need to understand for which subsets of the autism spectrum [bumetanide will work]."
The diuretic drug was initially approved to alleviate fluid retention in people with heart, liver or kidney disease, and it has been used to treat high blood pressure. Research in rodents suggests that it also affects the function of the chemical messenger gamma-aminobutyric acid (GABA), which dampens brain signals and is thought to be important in autism. Scientists speculate that the drug normalizes levels of chloride ions in the brain: High chloride levels cause GABA to excite brain signals rather than inhibit them. If bumetanide helps bring the level of chloride ions back down, it may restore GABA's inhibitory effects.
The new results, though, "are quite different than the previous reports that bumetanide has broad positive effects on autism symptoms," says Jeremy Veenstra-VanderWeele, professor of psychiatry at Columbia University, who was not involved in the study. "This was a carefully run study with a lot of thought put into the study design."
Restoring balance:
Bruining's team enrolled 92 autistic children aged 7 to 15 years in the clinical trial. Parents gave their children a syrup solution twice a day for 91 days; 47 children got a solution containing bumetanide — a low dose for the first week and then a higher one — and 45 got a placebo.
The trial was 'double blind,' meaning neither the researchers nor the participants and their parents knew who took which formula. Because increased urination and low potassium in the blood are known side effects of bumetanide, researchers instructed both groups to drink more water and take potassium supplements. That way, it would not be immediately obvious to participants and their caregivers which children received the drug versus placebo.
At the start and end of the trial, the researchers assessed each participant's social-communication skills using a standardized parent questionnaire called the Social Responsiveness Scale. The team used other tests to assess restricted and repetitive behaviors and responses to sensory stimuli, which served as secondary outcome measures. They also measured the participants' brain waves, using electroencephalography (EEG), for use in future studies.
As a group, children taking bumetanide showed no more improvement in social skills than those taking the placebo, the researchers found. But the bumetanide group did show a statistically significant decrease in restricted and repetitive behaviors.
Additional analyses suggested that younger participants show more improvement in social communication and responsiveness than older participants, and that girls show more improvement in repetitive behaviors than boys do. The study was published in July in the Journal of the American Academy of Child and Adolescent Psychiatry.
Stratifying participants:
The study's design and enrollment criteria make it difficult to draw comparisons with previous work, says Yehezkel Ben-Ari, president and co-founder of French biotech firm Neurochlore, which owns the patent for bumetanide as an autism treatment.
Ben-Ari's team reported in 2012 and again in 2017 that bumetanide leads to significant decreases in autism traits. But these studies measured the drug's effects based primarily on a clinician's impressions of autism severity, although one did assess parent ratings as a secondary measure. The previous studies also included children with lower cognitive abilities than the new study's participants; among children with higher abilities, there may be less room to show improvements.
Even though the trial did not yield positive results in its primary outcome measure, it does suggest that bumetanide is still useful for certain people, especially those whose autism may be linked to an imbalance in chloride ions that affects GABA, Bruining says.
He and his team are analyzing the EEG data they collected to determine patterns of brain activity that predict a response to bumetanide. One such biomarker, he says, may be the excitation-inhibition ratio in the brain at a network level, as measured by brain wave oscillations2.
"Bumetanide has substantial, strong effects on brain oscillations," Bruining says of a not-yet-published follow-up study. His goal is to identify specific patterns of brain oscillations that predict a person's response to the drug.
Stratifying people by EEG could provide a clear and less subjective outcome measure for future bumetanide trials, Ben-Ari says. Clinical questionnaires can leave much room for interpretation, he says, but with EEG, "there's nothing to debate."
This article was originally published on Bumetanide may benefit only a subset of autistic children
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