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About Haematologica
Defining niche interactions to target chronic myeloid leukemia stem cells
Rebecca Mitchell and
Mhairi Copland⇑
Paul O'Gorman Leukaemia Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, UK
E-mail: MHAIRI COPLAND - mhairi.copland{at}glasgow.ac.uk
In this issue of Haematologica, Godavarthy et al.1 describe how the expression of CD44 on the surface of leukemic stem cells (LSC) and E-selectin on bone marrow (BM) endothelium are essential for the engraftment of LSC within the BM niche. They show how this interaction can provide the LSC with protection from imatinib treatment. Importantly, disruption of this axis using an E-selectin inhibitor in combination with imatinib prevents LSC binding to the endothelium and demonstrates superior eradication of LSC in chronic myeloid leukemia (CML) compared with imatinib alone.
CML has been well characterized for a number of years, since the discovery of the Philadelphia chromosome and associated aberrant BCR-ABL signaling. This led to the revolutionary development of BCR-ABL-specific tyrosine kinase inhibitors such as imatinib. Tyrosine kinase inhibitors are highly effective at reducing the leukemic burden and disease progression, inducing remission and prolonging survival of patients with chronic phase CML.2 Although very good control over the disease is gained in most chronic phase CML patients with tyrosine kinase inhibitor treatment, eradication of the LSC population, which sustains and repopulates the disease in patients, remains elusive.3
It has been established that the BM niche provides a sanctuary for LSC in which to thrive and avoid pharmacological interventions. There have been many studies showing how the niche adapts and is exploited during leukemic transformation.4–6 By gaining, a better understanding of the interactions between LSC and their microenvironment, it may be possible to distinguish factors that favor survival of the leukemic cells and identify targets for improved drug therapy. One such strategy is to inhibit the homing and engraftment of LSC within the BM niche, without affecting normal hematopoietic stem cells (HSC).7
The BM microenvironment is complex, due to the array of different cell types which reside there, including osteolineage cells, mesenchymal stem cells, endothelial cells, neurons and hematopoietic cells.8 In order to control and maintain homeostasis of the healthy BM niche, a multitude of cytokines and chemokines help determine HSC fate.8 In normal hematopoiesis homing and engraftment of HSC within the BM is a highly coordinated multistep process that requires activation of different adhesion receptors to maintain tight regulation. Selectins and integrins are very important within this process.9,10 Expression of integrins allows HSC to bind to vascular cell adhesion molecule-1 on BM endothelium and fibronectin on the extracellular matrix. Integrins, such as VLA4, also interact with E- and P-selectins, which are found constitutively expressed on the BM endothelium, and this interaction mediates HSC rolling and homing.10 Another important factor within this process is CXCL12; this chemkine functions as an HSC chemoattractant through its receptor CXCR4, which through crosstalk with β1 and β2 integrins, mediates HSC homing and is required for stable engraftment.9 CD44 has also been linked to HSC homing; however, HSC that do not express CD44 can still home and engraft normally.11
In studies comparing the homing and engraftment of CML LSC to normal HSC, it has been shown that patients with CML have several adhesion abnormalities.12,13 LSC have defective β1 integrin function, despite normal expression of VLA4 and VLA5, which decreases LSC adhesion to BM stroma.13 It has also been shown that primary CML progenitor cells have reduced CXCR4 expression and impaired chemotaxis towards CXCL12, as well as reduced CXCL12-mediated integrin adhesion.12 Despite these functional defects, LSC can still home and engraft within the BM and therefore must use alternative mechanisms.
Godavarthy et al.1 demonstrate a novel reciprocal link between the external cues from the BM microenvironment and BCR-ABL-specific LSC-intrinsic pathways. They show how this leads to modulation of the expression of LSC adhesion molecules and alters interactions with the vascular niche. The authors confirm the interaction of BCR-ABL+ cells and the vascular endothelium by using very sophisticated in vivo microscopy of the calvarium of mice injected with human CML leukocytes. Using time-lapse imaging, they found that the contact time of the leukemic cells to the BM endothelium was reduced in mice treated with an E-selectin inhibitor (GMI-1271).
The authors replicated these findings in a transgenic model, showing that BCR-ABL+ cells were situated significantly further away from the endothelium if treated with GMI-1271 and imatinib. Furthermore, after treatment with GMI-1271 and imatinib, mice had improved survival, and demonstrated reduced numbers of CML-initiating clones, impaired short-term homing to the spleen and the BM, reduced leukocyte counts, BCR-ABL+ myeloid cell counts and spleen size. Further studies showed that inhibition of E-selectin led to non-adhesion and an increase of Scl/Tal1 expression in BCR-ABL+ leukemia-initiating cells (LIC) in vitro. Additionally, Scl/Tal1 negatively regulated the expression of CD44 on LIC, and overexpression of Scl/Tal1 on LIC led to prolongation of survival in a murine model of CML, similar to the improved survival with CD44-deficient CML-initiating cells previously demonstrated by Krause et al.14
In vitro experiments demonstrated that CD44 was highly expressed in BCR-ABL+ cells compared to BCR-ABL− cells, and that when BCR-ABL+ cells were treated with GMI-1271 alone or in combination with imatinib there was an increase in cells in G2-S-M phase and a decrease in the G0 phase of the cell cycle. This coincided with an increase in cell cycle promoter CDK6 and decreased expression of cell cycle inhibitor p16. Furthermore, BCR-ABL1 phosphorylated SCL/TAL1 via the AKT signaling pathway. SCL/TAL1 regulated the activity of the CD44 regulatory element by acting as a transcriptional repressor leading to decreased expression of CD44, decreased adhesion to the vascular niche and an increase in cycling LSC.
This schematic demonstrates the effects of E-selectin inhibition within the bone marrow microenvironment and the impact upon chronic myeloid leukemia stem cells and mechanistically how this is controlled by the SCL/TAL1 – CD44 axis. HPC: hematopoietic progenitor cell; HSC; hematopoietic stem cell; LSC: leukemic stem cell.
Interestingly, higher expression of CD44 was demonstrated in BCR-ABL cells specifically harboring the T315I mutation, which correlated with increased binding to E-selectin, with a larger amount of adherent cells in G0. The authors suggest that the increased expression of CD44 and increased binding to E-selectin may contribute to LSC dormancy and resistance to tyrosine kinase inhibitors.
Finally, relevance to human CML was established as leukocytes from patients with CML had higher transcriptional expression of SCL/TAL1 and lower CD44 expression compared to those from healthy individuals. Analyses of published datasets suggest a trend that expression of SCL/TAL1 and CD44 may correlate with disease stage and survival in CML patients; however, larger cohorts and further experimental data are required to confirm this.
The important experiments presented by Godavarthy et al. establish the mechanism of increased expression of CD44 on BCR-ABL1+ cells. They further showed that dislocation of BCR-ABL1+ cells from the niche, via inhibition of E-selectin binding, increased BCR-ABL+ cell cycle progression and increased responsiveness to imatinib therapy.1
Inhibition of E-selectin has been shown to have therapeutic utility in other cancer types, such as acute myeloid leukemia and solid tumors in which it is thought to have a role in metastasis.15 In acute myeloid leukemia, the leukemic blast cells bind to E-selectin on the endothelium and this activates leukemic pathways that contribute to chemotherapy resistance.16 Currently, GMI-1271 is in a phase I/II clinical trial to treat acute myeloid leukemia in combination with chemotherapy to disrupt leukemia survival pathways and sensitize the leukemic cells to chemotherapy (ClinicalTrials.gov Identifier: NCT02306291)
E-selectin has also been implicated in the development of metastasis to the lungs from primary solid tumors, such as breast17 and colon18 cancer. It is hypothesized that, during the premetastatic stage, the primary tumors secrete soluble factors, which induce an inflammatory response in the blood vessels and activate E-selectin on the endothelium, allowing engraftment of immune progenitor cells. This initial binding of E-selectin to its ligand confers firm adhesion, and triggers signaling that leads to permabilization of the endothelium through the dissociation of VE-cadherin/β-catenin. In an attempt to counteract metastasis, the E-selectin inhibitor GMI-1271 is currently being tested in preclinical models and is showing high efficacy.17 As well as being a therapeutic target, E-selectin is also being screened as a potential biomarker for disease progression and metastasis.19
The BM microenvironment is a developing research focus which is showing great importance in disease pathophysiology. Advances in technology, such as the time-lapse intra-vital imaging used in the study by Godavarthy et al.,1 are enabling a greater understanding of the interactions and mechanisms involved in cellular microenvironments This type of pioneering microscopy allows us to see interactions between leukemic cells and the niche, and is providing powerful data, as exemplified by this study as well as many others.13 Enriching these data, single-cell RNA-sequencing allows for the analysis of the different cell types within the niche, evaluation of their transcriptional regulation and a view of how they may contribute to disease progression, providing important information which may have been masked using bulk sequencing approaches.20 Through these studies, we continue to build upon our knowledge of the pathophysiology of CML and come ever closer to finding a way of eradicating quiescent LSC.
Copyright© 2020 Ferrata Storti Foundation
Godavarthy PS,
Kumar R,
Herkt SC,
. The vascular bone marrow niche influences outcome in chronic myeloid leukemia via the E-selectin - SCL/TAL1 - CD44 axis. Haematologica. 2019;05(1):136–147.
Hochhaus A,
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Guilhot F,
. Long-term outcomes of imatinib treatment for chronic myeloid leukemia. N Engl J Med. 2017;376(10):917–927.
Graham SM,
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. Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. Blood. 2002;99(1):319–325.
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. Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region. Nat Biotechnol. 2007;25(11):1315–1321.
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Welner RS,
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. Treatment of chronic myelogenous leukemia by blocking cytokine alterations found in normal stem and progenitor cells. Cancer Cell. 2015;27(5):671–681.
Krause DS,
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. Kinetics of in vivo homing and recruitment into cycle of hematopoietic cells are organ-specific but CD44-independent. Bone Marrow Transplant. 2000;26(5):559–566.
Zhang B,
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. Altered microenvironmental regulation of leukemic and normal stem cells in chronic myelogenous leukemia. Cancer Cell. 2012;21(4):577–592.
Bhatia R,
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. The effect of interferon-α on beta-1 integrin mediated adhesion and growth regulation in chronic myelogenous leukemia. Leuk Lymphoma. 1998;28(3-4):241–254.
Lazarides K,
. Requirement for CD44 in homing and engraftment of BCR-ABL–expressing leukemic stem cells. Nat Med. 2006;12(10):1175–1180.
Erbani J,
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Winkler I
. Vascular niche E-selectin promotes acute myeloid leukemia resistance to chemotherapy via its receptors CD44 and CD162. Exp. Hematol. 2018;64:S63.
Chien S,
Haq SU,
Pawlus M,
. Adhesion of acute myeloid leukemia blasts to E-selectin in the vascular niche enhances Their Survival By Mechanisms Such As Wnt Activation. Blood. 2013;122(21):61.
Kang SA,
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. The effect of soluble E-selectin on tumor progression and metastasis. BMC Cancer. 2016;16:331.
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. E-/P-selectins and colon carcinoma metastasis: first in vivo evidence for their crucial role in a clinically relevant model of spontaneous metastasis formation in the lung. Br J Cancer. 2010;102(3):602–609.
Aref S,
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. L and E selectins in acute myeloid leukemia: expression, clinical relevance and relation to patient outcome. Hematology. 2002;7(2):83–87.
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. The bone marrow microenvironment at single-cell resolution. Nature. 2019;569(7755):222–228.
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Billionaire Hospitals Took Bailouts, Laid Off Workers And Paid CEOs MILLIONS
HCA Healthcare is one of the world's wealthiest hospital chains. It earned more than $7 billion in profits over the past two years. It is worth $36 billion. It paid its chief executive $26 million in 2019.
But as the coronavirus swept the country, employees at HCA repeatedly complained that the company was not providing adequate protective gear to nurses, medical technicians and cleaning staff. Last month, HCA executives warned that they would lay off thousands of nurses if they didn't agree to wage freezes and other concessions.
A few weeks earlier, HCA had received about $1 billion in bailout funds from the federal government, part of an effort to stabilize hospitals during the pandemic.
HCA is among a long list of deep-pocketed health care companies that have received billions of dollars in taxpayer funds but are laying off or cutting the pay of tens of thousands of doctors, nurses and lower-paid workers. Many have continued to pay their top executives millions, although some executives have taken modest pay cuts.
The New York Times analyzed tax and securities filings by 60 of the country's largest hospital chains, which have received a total of more than $15 billion in emergency funds through the economic stimulus package in the federal CARES Act.
The hospitals — including publicly traded juggernauts like HCA and Tenet Healthcare, elite nonprofits like the Mayo Clinic, and regional chains with thousands of beds and billions in cash — are collectively sitting on tens of billions of dollars of cash reserves that are supposed to help them weather an unanticipated storm. They awarded their five highest-paid officials about $874 million in the most recent year for which they have disclosed their finances.
At least 36 of those hospital chains have laid off, furloughed or reduced the pay of employees as they try to save money during the pandemic.
Industry officials argue that furloughs and pay reductions allow hospitals to keep providing essential services at a time when the pandemic has gutted their revenue.
But more than a dozen workers at the wealthy hospitals said in interviews that their employers had put the heaviest financial burdens on front-line staff, including low-paid cafeteria workers, janitors and nursing assistants. They said pay cuts and furloughs made it even harder for members of the medical staff to do their jobs, forcing them to treat more patients in less time.
Even before the coronavirus swept America, forcing hospitals to stop providing lucrative nonessential surgery and other services, many smaller hospitals were on the financial brink. In March, lawmakers sought to address that with a vast federal economic stimulus package that included $175 billion for the Department of Health and Human Services to hand out in grants to hospitals.
But the formulas to determine how much money hospitals receive were based largely on their revenue, not their financial needs. As a result, hospitals serving wealthier patients have received far more funding than those that treat low-income patients, according to a study by the Kaiser Family Foundation.
One of the bailout's goals was to avoid job losses in health care, said Zack Cooper, an associate professor of health policy and economics at Yale University who is a critic of the formulas used to determine the payouts. "However, when you see hospitals laying off or furloughing staff, it's pretty good evidence the way they designed the policy is not optimal," he added.
The Mayo Clinic, with more than eight months of cash in reserve, received about $170 million in bailout funds, according to data compiled by Good Jobs First, which researches government subsidies of companies. The Mayo Clinic is furloughing or reducing the working hours of about 23,000 employees, according to a spokeswoman, who was among those who went on furlough. A second spokeswoman said that Mayo Clinic executives have had their pay cut.
Seven chains that together received more than $1.5 billion in bailout funds — Trinity Health, Beaumont Health and the Henry Ford Health System in Michigan; SSM Health and Mercy in St. Louis; Fairview Health in Minneapolis; and Prisma Health in South Carolina — have furloughed or laid off more than 30,000 workers, according to company officials and local news reports.
The bailout money, which hospitals received from the Health and Human Services Department without having to apply for it, came with few strings attached.
Katherine McKeogh, a department spokeswoman, said it "encourages providers to use these funds to maintain delivery capacity by paying and protecting doctors, nurses and other health care workers." The legislation restricts hospitals' ability to use the bailout funds to pay top executives, although it doesn't stop recipients from continuing to award large bonuses.
The hospitals generally declined to comment on how much they are paying their top executives this year, although they have reported previous years' compensation in public filings. But some hospitals furloughing front-line staff or cutting their salaries have trumpeted their top executives' decisions to take voluntary pay cuts or to contribute portions of their salary to help their employees.
The for-profit hospital giant Tenet Healthcare, which has received $345 million in taxpayer assistance since April, has furloughed roughly 11,000 workers, citing the financial pressures from the pandemic. The company's chief executive, Ron Rittenmeyer, told analysts in May that he would donate half of his salary for six months to a fund set up to assist those furloughed workers.
But Mr. Rittenmeyer's salary last year was a small fraction of his $24 million pay package, which consists largely of stock options and bonuses, securities filings show. In total, he will wind up donating roughly $375,000 to the fund — equivalent to about 1.5 percent of his total pay last year.
A Tenet spokeswoman declined to comment on the precise figures.
The chief executive at HCA, Samuel Hazen, has donated two months of his salary to a fund to help HCA's workers. Based on his pay last year, that donation would amount to about $237,000 — or less than 1 percent — of his $26 million compensation.
"The leadership cadre of these organizations are going to need to make sacrifices that are commensurate with the sacrifices of their work force, not token sacrifices," said Jeff Goldsmith, the president of Health Futures, an industry consulting firm.
Many large nonprofit hospital chains also pay their senior executives well into the millions of dollars a year.
Dr. Rod Hochman, the chief executive of the Providence Health System, for instance, was paid more than $10 million in 2018, the most recent year for which records are available. Providence received at least $509 million in federal bailout funds.
A spokeswoman, Melissa Tizon, said Dr. Hochman would take a voluntary pay cut of 50 percent for the rest of 2020. But that applies only to his base salary, which in 2018 was less than 20 percent of his total compensation.
Some of Providence's physicians and nurses have been told to prepare for pay cuts of at least 10 percent beginning in July. That includes employees treating coronavirus patients.
Stanford University's health system collected more than $100 million in federal bailout grants, adding to its pile of $2.4 billion of cash that it can use for any purpose.
Stanford is temporarily cutting the hours of nursing staff, nursing assistants, janitorial workers and others at its two hospitals. Julie Greicius, a spokeswoman for Stanford, said the reduction in hours was intended "to keep everyone employed and our staff at full wages with benefits intact."
Ms. Greicius said David Entwistle, the chief executive of Stanford's health system, had the choice of reducing his pay by 20 percent or taking time off, and chose to reduce his working hours but "is maintaining his earning level by using paid time off." In 2018, the latest year for which Stanford has disclosed his compensation, Mr. Entwistle earned about $2.8 million. Ms. Greicius said the majority of employees made the same choice as Mr. Entwistle.
HCA's $1 billion in federal grants appears to make it the largest beneficiary of health care bailout funds. But its medical workers have a long list of complaints about what they see as penny-pinching practices.
Since the pandemic began, medical workers at 19 HCA hospitals have filed complaints with the Occupational Safety and Health Administration about the lack of respirator masks and being forced to reuse medical gowns, according to copies of the complaints reviewed by The Times.
Ed Fishbough, an HCA spokesman, said that despite a global shortage of masks and other protective gear, the company had "provided appropriate P.P.E., including a universal masking policy implemented in March requiring all staff in all areas to wear masks, including N95s, in line with C.D.C. guidance."
Celia Yap-Banago, a nurse at an HCA hospital in Kansas City, Mo., died from the virus in April, a month after her colleagues complained to OSHA that she had to treat a patient without wearing protective gear. The next month, Rosa Luna, who cleaned patient rooms at HCA's hospital in Riverside, Calif., also died of the virus; her colleagues had warned executives in emails that workers, especially those cleaning hospital rooms, weren't provided proper masks.
Around the time of Ms. Luna's death, HCA executives delivered a warning to officials at the Service Employees International Union and National Nurses United, which represent many HCA employees. The company would lay off up to 10 percent of their members, unless the unionized workers amended their contracts to incorporate wage freezes and the elimination of company contributions to workers' retirement plans, among other concessions.
Nurses responded by staging protests in front of more than a dozen HCA hospitals.
"We don't work in a jelly bean factory, where it's OK if we make a blue jelly bean instead of a red one," said Kathy Montanino, a nurse treating Covid-19 patients at HCA's Riverside hospital. "We are dealing with people's lives, and this company puts their profits over patients and their staff."
Mr. Fishbough, the spokesman, said HCA "has not laid off or furloughed a single caregiver due to the pandemic." He said the company had been paying medical workers 70 percent of their base pay, even if they were not working. Mr. Fishbough said that executives had taken pay cuts, but that the unions had refused to take similar steps.
"While we hope to continue to avoid layoffs, the unions' decisions have made that more difficult for our facilities that are unionized," he said. The dispute continues.
Apparently anticipating a strike, a unit of HCA recently created "a new line of business focused on staffing strike-related labor shortages," according to an email that an HCA recruiter sent to nurses.
The email, reviewed by The Times, said nurses who joined the venture would earn more than they did in their current jobs: up to $980 per shift, plus a $150 "Show Up" bonus and a continental breakfast.
The post Hospitals Got Bailouts and Furloughed Thousands While Paying C.E.O.s Millions appeared first on New York Times.

redpajama_set_name: RedPajamaCommonCrawl


Olive Tree Genealogy Blog: Good News! Finding Your Roots Returns Jan 5/16!
An internal review found that Gates "violated PBS standards" by, among other things, not informing executives at PBS or producing station WNET about Affleck's request to censor the show's genealogical research into his ancestors.
After an internal review, an additional researcher/fact-checker, another genealogist and an expert in DNA-based genealogical research have been added.
In the new season of Finding Your Roots Gates traces the ancestral trails of 28 new guests including Maya Rudolph, Richard Branson, Soledad O'Brien, Bill Hader, Julianne Moore, Keenen Ivory Wayans, Senator John McCain, Norman Lear, Shonda Rhimes, and more.
Major corporate support for the third season of Finding Your Roots is provided by Ancestry.com , Johnson & Johnson, POM and the Ford Motor Company.
I am so happy that the show will continue!
I'm glad too. What was needed to fix this error was pretty simple and it sounds like they've made the right adjustments. Ben Affleck's mistake should serve as a teaching moment for others, both those who are subjects on shows like this and those who host them.
If it was up to me this show would be on every week, would run 90 minutes, and would begin to teach everyone more about the vlaue of archives and just what DNA testing really can and can't do. Millions of Americans spend vast amounts of time learning the stats of their favorite athletes and teams, which is entirely artificial entertainment; an entertaining approach to genealogy would allow more of us to learn our real attachments to history, and thus to the present.


When it comes to commercial plumbing contractors serving the Burien, WA area, Vortex Plumbing, Inc. ranks among the best! We are a licensed and insured plumbing company that caters to the needs of all types of businesses, big and small. We have vast experience in plumbing work in schools, administrative buildings, office complexes and other commercial properties.
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With us handling your commercial plumbing needs, you can be sure that your customers, staff and business associates will be comfortable using the efficient, code-compliant plumbing system.
There is no way you can hire anyone but experienced professionals to handle a plumbing job on your retail or other commercial property. While a DIY approach is ill-advised with residential plumbing services, going DIY or hiring the neighborhood handyman can also cost a business big.
Why invite needless trouble for your company when we are here to provide quality commercial plumbing services in Burien at affordable rates? We strive to fulfill your plumbing repair, installation, replacement and maintenance needs in the best way possible.
Hiring plumbing repair and replacement services is part of running a business. Whether you own a retail establishment that gets a steady flow of customers or you run another other type of enterprise, a breakdown in the plumbing system can affect your bottom line badly.
Call us for regular plumbing inspections and water or sewer line cleaning to keep your commercial plumbing system well-maintained. Give us a call immediately if any need for plumbing repair arises on your commercial property.
Rely on Vortex Plumbing Inc. for all the commercial plumbing services you need in Burien. Call (206) 430-1919 to schedule the visit of our commercial plumber to your business place.


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You are here: Home / App / How Prisma Makes Instagram Better
How Prisma Makes Instagram Better
Prisma has changed the way Instagram users view their favorite photos. This artistic spin on pictures and related content is one of the most popular filter based apps for a range of reasons. Whether you're new to Prisma or just want a better look at what makes it a favorite among users, our guide has got the answers.
Prisma Description
What is Prisma? It's a question that many Instagram users had after the app's initial launch. Prisma turns anyone into an artist with a few simple steps. Take a photo and adjust the options to find the right look. With a range of popular artists mimicked among the app, it's something there for every wannabe artist.
Which Artists Are Replicated Through This App?
A range of choices bring up various artists as well as their unique styles. In some cases, the filters replicate the look and style of a specific piece. Well known artists like Marc Chagall and Roy Lichtenstein have filters that are specifically named after them. For filters designed after certain pieces of art, the names reflect a certain element of the painting or its title. Filters like Wave and Transverse Line directly take their names from actual works. Look for influences based on other influential creators such as anime icon Hayao Miyazaki. His work can be seen through the Mononoke selection.
Sharing Based On Location
It's all about your location when uploading photos to Instagram. Prisma uses your location to reach other users in your area. As they find and like your work, it helps spread the art to Instagram vast community. By doing this, it gives you more control over how it spreads and who provides those all important first critiques of new additions.
Find Other Artwork Created With Prisma
Prisma allow encourages user participation in other ways. One of the best choices give users a chance to look at uploaded works from today, yesterday or since the app's creation. It's a great place for beginners to start before uploading their own selections. In some cases, other users discuss the filter they used as well as other helpful techniques. That makes Prisma a mini art school for amateur and professional photographers.
Cropping Features
As with other photo filters, cropping is available. With change in aspect ratio presentation, this feature is more important than ever. Luckily, it has been adapted to better utilize those all important ratios and present them in the clearest possible versions.
What Makes It Work?
It's easy to say what is Prisma and even easier to describe the aspects that make it work. Look no further than artificial intelligence, AI, for its foundation for success. Prisma Labs is adamant about the app's ability to use AI in every aspect of its operation. With AI included, it helps the user focus on simple steps, instead of complicated image alterations. Understanding every part of the image and how it relates to the specific filter also avoids any errors such as blurring or gaps in photo adaptations.
High Resolution Results
One of the most popular elements of Prisma has been its ability to produce high resolution images. This is especially important to photographers who want to retain the clear, crisp nature of their selected pictures. Certain updates to the app has meant compromised graphics at some points, but the issues usually correct themselves with the next update.
Use On Facebook as well as Instagram
Since Facebook owns Instagram, it was only natural that Prisma would extend it features to Facebook posts. You can choose to upload your photo to Instagram, Facebook or both. Those choices provide even more flexability when filtering how your work is viewed.
Is It Available On All Devices?
Yes. If your device features Instagram, it can accommodate the app. Available on both iTunes and Google Play, Prisma is easy to find and downloads quickly. These sites also feature reviews as well as star ratings about the content. In each case, they showcase the Instagram community's love for the app.
When it comes to Prisma, one of the top questions is about its cost. Prisma in both its Apple and Android versions are free to use. Additional in-app purchases may be added or changed by the maker without notice.
As with any app, Prisma asks for selected permissions to operate at optimum levels. Location setting require access to your GPS system for accurate reading and placement information. The app may reach into and modify USB storage. It reserves the right to delete or alter any content in this section. Allowing access to a device's camera means it can take photos as well as video at any time. In most cases, this feature helps it speed up content creation.
Prisma offers full customer support to the app's users. Contacting the company through Prisma's official website is the best way to take advantage of this option.
Who Created Prisma?
Alexey Moiseenkov created Prisma. In 2016, after working with companies like Yandex, he decided to bring his expertise to world of app development. When Prisma was released, it became an instant sensation. That led Moiseenkov to create Prisma Labs. This venture is now the official home for the app and everything related to it.
Among Instagram filters, Prisma is unrivaled. The app brings our ordinary pictures to life and turn them into a work of art. It's the perfect way to turn your feed into the gallery of your dreams.
Bumble vs Tinder: Which Dating App is Better?


Many thanks to Forsyth Family magazine for letting TMoM rerun this article today. After spending four college years in Ohio, I have grown to love Buckeyes, especially around the holidays. No matter what part of the country you live in, this melt-in-your-mouth dessert is the perfect ending to a holiday meal or as a gift. If you are looking for a new treat this season, I highly suggest you give this recipe a try!
How about a brief history lesson on the state tree of Ohio? The Buckeye is the state tree of Ohio. It produces small nuts, with a dark outer shell and a lighter interior, which is visible from the top. This confectionery version resembling the beloved nut is made with a creamy peanut butter center and a milk chocolate outer shell.
A holiday tradition in my family, Buckeyes make the perfect holiday gift for neighbors, teachers and friends. Their peanut-butter-cup taste appeals to a wide audience, and their easy assembly makes this no fuss for you, either.
Line a baking sheet with parchment. Beat the confectioners' sugar, peanut butter, butter, vanilla and salt with an electric mixer in a medium bowl until well combined. Scoop out 2-teaspoonful mounds and roll into balls; arrange them on the prepared baking sheet. Refrigerate until firm, about 20 minutes.
Microwave the chocolate and shortening in a microwave-safe medium bowl in 30-second increments, stirring in-between, until the mixture is completely melted and smooth—about 2 minutes.
Stick a toothpick or skewer into the top center of a peanut butter ball. Dip the ball into the melted chocolate, leaving a circle of peanut butter visible on top. Let the excess chocolate drip off, then return the buckeye to the baking sheet. Repeat with the remaining peanut butter balls and chocolate.
Chill the buckeyes until firm, about 30 minutes. Smooth out the hole left by the toothpick with an offset spatula. Serve at room temperature or well chilled. Refrigerate in an airtight container for up to 5 days.


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Wiktor Iljicz Aleksandriuk (ros. Виктор Ильич Александрюк, ur. 30 września 1922 w Kursku, zm. 11 września 1991 tamże) – radziecki lotnik wojskowy, kapitan, Bohater Związku Radzieckiego (1945).

Życiorys
Do 1940 skończył 10 klas szkoły i aeroklub w Kursku, od czerwca 1940 służył w Armii Czerwonej, w czerwcu 1941 ukończył wojskową szkołę lotniczą w Czuhujewie. Od czerwca 1941 uczestniczył w wojnie z Niemcami jako pilot 13 samodzielnej eskadry lotnictwa myśliwskiego kujbyszewskiego rejonu obrony przeciwlotniczej, biorąc udział m.in. w osłanianiu przez nalotami obiektów w Syzraniu, od maja do października 1942 był pilotem 171 pułku lotnictwa myśliwskiego w tulskim rejonie obrony przeciwlotniczej i na Froncie Briańskim, osłaniając obiekty w obwodzie tulskim i podczas operacji woronesko-woroszyłowgradzkiej. Od grudnia 1942 do maja 1945 był pilotem i dowódcą klucza 19 pułku lotnictwa myśliwskiego (od sierpnia 1944: 176 gwardyjskiego pułku lotnictwa myśliwskiego) kolejno na Froncie Woroneskim (grudzień 1942–marzec 1943), 1 Froncie Ukraińskim (styczeń–czerwiec 1944) i 1 Froncie Białoruskim (czerwiec 1944–maj 1945), brał udział w operacji ostrorożsko-rossoszańskiej, woronesko-kastorneńskiej, charkowskiej, proskurowsko-czerniowieckiej, brzesko-lubelskiej, warszawsko-poznańskiej, pomorskiej i berlińskiej. Wykonał ok. 300 lotów bojowych myśliwcami MiG-3, Ła-5 i Ła-7, stoczył 77 walk powietrznych, w których strącił osobiście 23 i w grupie 4 samoloty wroga. Po wojnie do października 1948 w lotnictwie obrony przeciwlotniczej był dowódcą klucza i zastępcą dowódcy eskadry 176 gwardyjskiego pułku lotnictwa myśliwskiego w Moskiewskim Okręgu Wojskowym, od lutego 1949 do września 1950 zastępcą dowódcy eskadry w 177 i 18 gwardyjskim pułku lotnictwa myśliwskiego w moskiewskim rejonie obrony przeciwlotniczej, a od września 1950 na Dalekim Wschodzie. Od grudnia 1950 do lata 1951 był pilotem w 232 pułku lotnictwa szturmowego w Łucku, 1951–1953 zastępcą dowódcy eskadry 192 pułku lotnictwa myśliwskiego w Stanisławowie, a od kwietnia do czerwca 1953 dowódcą klucza w 4 Centrum Przysposobienia Bojowego Sił Powietrznych w Tambowie, następnie został zwolniony do rezerwy w stopniu kapitana.

Odznaczenia
 Złota Gwiazda Bohatera Związku Radzieckiego (29 czerwca 1945)
 Order Lenina (29 czerwca 1945)
 Order Czerwonego Sztandaru (trzykrotnie, 2 kwietnia 1943, 25 lipca 1944 i 29 marca 1945)
 Order Wojny Ojczyźnianej I klasy (11 marca 1985)
 Order Czerwonej Gwiazdy (31 lipca 1948)
Medal "Za Odwagę" (31 lipca 1942)
Medal "Za zasługi bojowe" (15 listopada 1950)
I inne.

Bibliografia
 Александрюк Виктор Ильич (ros.) Biogram na stronie warheroes.ru [dostęp 2018-12-08]

Radzieccy kapitanowie lotnictwa
Rosyjscy Bohaterowie Związku Radzieckiego
Ludzie urodzeni w Kursku
Odznaczeni medalem "Za Odwagę" (ZSRR)
Odznaczeni Medalem Za Zasługi Bojowe
Odznaczeni Orderem Czerwonego Sztandaru
Odznaczeni Orderem Lenina
Odznaczeni Orderem Wojny Ojczyźnianej I klasy
Radzieccy lotnicy wojskowi
Radzieccy żołnierze II wojny światowej
Urodzeni w 1922
Zmarli w 1991

redpajama_set_name: RedPajamaWikipedia


The lovely Loughrigg Spiral Hat Knitting Pattern will make you the perfect lightweight hat. This smart hat for men and women uses lightweight DK/sport yarn and has a delicate lace work pattern to produce a stylish spiral swirl. Buy this pattern as a download here, or receive a premium printed version with extra instruction help cards and all the materials you need by buying the Loughrigg Spiral Hat Knit Kit.


We've all got that one friend who is convinced that the apocalypse is almost upon us - whether it be zombie, disease or nuclear war based - and has a part of their house set aside for storing provisions. We all laugh and make fun of them, but if the dreaded day comes, their house is the first one we'll be heading for.
Haynes's Zombie Survival Transport: Owners' Apocalypse Manual is a beautifully presented tongue in cheek look at how to ensure your vehicle is ready for the imminent zombie apocalypse. It provides information on the different kinds of zombies and their speed; how to convert your car / motorcycle / animal to ensure you have the best chance of survival.
The text is broken up by humour illustrations that are similar in style to those information sheets on trains and planes that tell you how to act in an emergency.
This is an amusing book that is great to dip in and out of. It's probably more of a gift purchase than it is a book you'd buy for yourself.


Last Friday, we gathered a dozen past staffers of WOSU AM as the station went off the air. (See previous blog post for more information on the shutdown of WOSU AM.) It was a time to reminisce about the old days of AM radio in Columbus.
Our thanks go out to everyone who made the afternoon special including WOSU's Amy Milbourne who contacted as many past WOSU AM announcers and managers as possible over a short period of time. Attending: Dale Ouzts, Don Davis, Fred Andrle, Tom Wiebell, Ken Keller, Charlie Pickard, Jim Varga, Bob Schweikart, Bill Cohen and Jo Ingles.
89.7 FM – Your New All Day NPR News Station!


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Home»Features»May 10: St. Damien of Moloka'i
May 10: St. Damien of Moloka'i
Catholic News Agency 2022-05-09
Catholic News Agency / May 9, 2022 / 288
The Catholic Church remembers St. Damien of Molokai on May 10. The Belgian priest sacrificed his life and health to become a spiritual father to the victims of leprosy quarantined on a Hawaiian island.
Joseph de Veuser, who later took the name Damien in religious life, was born into a farming family in the Belgian town of Tremlo in 1840. During his youth he felt a calling to become a Catholic missionary, an urge that prompted him to join the Congregation of the Sacred Hearts of Jesus and Mary.
Damien's final vows to the congregation involved a dramatic ceremony in which his superiors draped him in the cloth that would be used to cover his coffin after death. The custom was meant to symbolize the young man's solemn commitment, and his identification with Christ's own death. For Damien, the event would become more significant, as he would go on to lay down his life for the lepers of Molokai.
His superiors originally intended to send Damien's brother, a member of the same congregation, to Hawaii. But he became sick, and Damien arranged to take his place. Damien arrived in Honolulu in 1864, less than a century after Europeans had begun to establish a presence in Hawaii. He was ordained a priest the same year.
During his ninth year of the priesthood, Father Damien responded to his bishop's call for priests to serve on the leper colony of Molokai. A lack of previous exposure to leprosy, which had no treatment at the time, made the Hawaiian natives especially susceptible to the infection. Molokai became a quarantine center for the victims, who became disfigured and debilitated as the disease progressed.
The island had become a wasteland in human terms, despite its natural beauty. The leprosy victims of Molokai faced hopeless conditions and extreme deprivation, sometimes lacking not only basic palliative care but even the means of survival.
Inwardly, Fr. Damien was terrified by the prospect of contracting leprosy himself. However, he knew that he would have to set aside this fear in order to convey God's love to the lepers in the most authentic way. Other missionaries had kept the lepers at arms' length, but Fr. Damien chose to immerse himself in their common life and leave the outcome to God.
The inhabitants of Molokai saw the difference in the new priest's approach, and embraced his efforts to improve their living conditions. A strong man, accustomed to physical labor, he performed the Church's traditional works of mercy – such as feeding the hungry, sheltering the homeless, and giving proper burial to the dead – in the face of suffering that others could hardly even bear to see.
Fr. Damien's work helped to raise the lepers up from their physical sufferings, while also making them aware of their worth as beloved children of God. Although he could not take away the constant presence of death in the leper colony, he could change its meaning and inspire hope. The death-sentence of leprosy could, and often did, become a painful yet redemptive path toward eternal life.
The priest's devotion to his people, and his activism on their behalf, sometimes alienated him from officials of the Hawaiian kingdom and from his religious superiors in Europe. His mission was not only fateful, but also lonely. He drew strength from Eucharistic adoration and the celebration of the Mass, but longed for another priest to arrive so that he could receive the sacrament of confession regularly.
In December of 1884, Fr. Damien discovered that he had lost all feeling in his feet. It was an early, but unmistakable sign that he had contracted leprosy. The priest knew that his time was short. He undertook to finish whatever accomplishments he could, on behalf of his fellow colony residents, before the diseased robbed him of his eyesight, speech and mobility.
Fr. Damien suffered humiliations and personal trials during his final years. An American Protestant minister accused him of scandalous behavior, based on the contemporary belief that leprosy was a sexually transmitted disease. He ran into disagreements with his religious superiors, and felt psychologically tormented by the notion that his work had been a failure.
In the end, priests of his congregation arrived to administer the last sacraments to the dying priest. During the Spring of 1889, Fr. Damien told his friends that he believed it was God's will for him to spend the upcoming Easter not on Molokai, but in heaven. He died of leprosy during Holy Week, on April 15, 1889.
St. Damien of Molokai was beatified in 1995. Pope Benedict XVI canonized him in 2009.
Tags:BelgiumFather DamienHawaiiPope Benedict XVISt Damien of Molokai
Who is St. Damien of Molokai?
Obituary: Reverend James J. O'Connor
Founded in continued response to Pope John Paul II's call for a "New Evangelization," the Catholic News Agency (CNA) has been, since 2004, one of the fastest growing Catholic news providers to the English speaking world.
Cardinal Grech: Benedict XVI was misunderstood throughout his life
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FULL TEXT: Pope Francis' homily at Pope Emeritus Benedict XVI's funeral Mass


Hosam only turns up to stay with his friends two or three times a month now. He sleeps six or seven days a week at the factory. He has a good relationship with his boss but the pay is low and the work is hard.
The Saturday I visit, the guys' town an hour into the mountains from the tourist city of Antalya, conversations are dominated by the death of a Syrian man at a local construction site. The man was friends with many in Hosam and Walid's network — he was an Arabic teacher like Walid, working on a local construction site. The father of three fell from a height and died quickly.
Much of the talk among some of the men are the Islamic procedures for his widow's forty days of mourning– "But in this situation it is a bit difficult," explains Walid (the couple were living as refugees in a room with the man's brother) — and how they could pitch in to take care of her in his absence. Some of the details (how they regard the brother) are lost on me.
Hosam takes cold medicine. He has a decent phone and a few changes of clothes. The guys have internet now in their 'apartment' — five or six sleep on mattresses in what was originally designed to be a small store — the room's entire facade is transparent plastic. They cover it with sheets.
Hosam catches up on the FC Barcelona games in bed — Messi is his favourite player. He has food to eat and a place to sleep. It gets cold at night, the elevation higher than the city below. Conditions are hygienic enough. But there are no opportunities — the psychological pressure is that of complete stasis. It also wouldn't hurt if he was able to see a GP for a check up.


Canadian rapper Drake's new album, Views, debuted on the streaming service Apple Music last night, and has since been added to the iTunes Store, priced at $13.99. In a big coup for Apple, the album will, for its first week of availability, be kept away from other music streaming services such as Spotify.
As Drake was last year's most streamed artist on Spotify, the album's launch on Apple Music is likely to drive a big boost in subscribers for that service. And, once many Drake followers have signed up, they can enjoy a huge music library that also includes PVRIS's White Noise (Deluxe Version) and A$AP Ferg's Always Strive and Prosper, both of which are reviewed in our new issue.


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Government invites Syria to shop for weapons in London
Press team contact details
andrew@caat.org.uk
Outrage as Axis of Evil asked to London arms bazaar
Now release secret invite list, campaigners demand
Press conference 5th September, London Euston
Campaigners against next month's London arms bazaar have condemned revelations that the British government has invited Syria to shop for arms at a huge weapons exhibition in London in just two weeks time.
The Ministry of Defence, which is paying £400,000 towards the fair, has also invited to the arms bazaar, countries with terrible human rights abuse records, countries mired in civil conflict, and countries drowning in poverty.
It is amazing that Syria is called a terrorist sponsoring state and threatened with military action with one hand, while invited to shop for arms on British soil on the other. Both hands must be covered in blood, said Martin Hogbin, campaigns co-ordinator at Campaign Against Arms Trade. The invite could mean American arms companies are displaying weapons to the Syrian military which could then be used against them.
Much of the rest of the list is a roll-call of countries who should not be invited to shop for arms on British soil, at the taxpayers' expense, he continued.
Thousands of protesters are expected to descend on Defence Systems Equipment International (DSEI) which is taking place at the ExCeL centre on London's docklands, from 9th – 12th September 2003.
Scandal of the secret list
Campaigners today called for the release of a second secret list of countries invited to shop at DSEI 2003.
The Ministry of Defence advises the DSEI 2003 exhibition organiser, PGI Spearhead Exhibitions Ltd, on who to invite and is contributing nearly half-a-million pounds to the weapons fair.
But Spearhead and the MoD have refused to release this second list of invited countries.
It is a scandal that the government is paying for this arms fair with taxpayer's money and advised the exhibition organisers on who to invite, but still the second list is kept secret, said Martin Hogbin.
The Ministry of Defence has already told journalists that Spearhead has drawn up its own list of invites, on which it consults the MoD. Yet, the MoD has also said it has no powers to prevent Spearhead inviting whichever countries it wants to the London arms fair.
Can it be true that a democratically elected government can't decide who comes to shop for arms on its soil? That secret list could mean yet more dictators, human rights abusers and terrible regimes could be invited to shop for weapons in London next month, continued Hogbin.
Investigative journalists managed to obtain the second list for DSEI 2001, and it revealed arms buyers from Angola, Uganda, Pakistan and Colombia were secretly invited to shop for arms.
It appears the Government can simply ask Spearhead to invite the countries it wants to come, but can't be seen to be asking, continued Hogbin.
Blair's invite list
The Labour government's list of invitations to the arms bazaar was published this morning on the website of the Defence Export Services Organisation (www.deso.mod.uk), the 600 staff strong government agency who's sole job it is to promote British arms equipment abroad.
Countries of concern to CAAT. which have officially been invited by the Government to shop for arms include Syria, India & Pakistan, Saudi Arabia, South Africa and Turkey
Martin Hogbin said:
Less than 12 months ago, India and Pakistan were teetering on the brink of nuclear war with each other. Even today, they are at each other's throats accusing each other of sponsoring terrorism. Inviting both of them to the arms fair illustrates how the Blair government is really more interested in flogging British weapons than making real progress towards peace.
The brutal regime in Saudi Arabia has been accused, even in recent weeks, of sanctioning torture and human rights abuse, even against British citizens. The Saudi royal family has also been accused of helping to fund Al Quaeda. Their invite to the London arms bazaar shows new Labour's true-colours on human rights and arms exports: however brutal or corrupt, you are welcome to buy weapons in London!
South Africa needs to spend money on the development of civil industry, water supplies, education, housing and health. With no identifiable threat, what South Africa doesn't need is yet more expensive weaponry. If the UK was really interested in helping heal the scar of Africa's poverty, we would not be inviting its leaders to spend yet more money on horrific weapons. South Africa has also recently been accused of corruption in a $4bn arms deal with some of the companies exhibiting at DSEI this year.
Turkey has a record of massive human rights violations, especially against Kurds in the south-east of the country, using British weaponry. Inviting Turkey to this arms fair not only provides them with the equipment to continue their brutal regime, but illustrates our Government turning a blind eye to human rights abuse.
CAAT is launching a detailed briefing about the countries and arms firms attending the DSEI 2003 exhibition on Tuesday 2nd September. Reserve your copy on 020 7281 0297, or visit the CAAT website after publication.
Protests Planned
A series of protests, direct actions and other anti-DSEI events have been planned for the week of the arms fair, including a mass demonstration in central London on 6th September, a Facing the Arms Traders event on the 9th September, the day the fair opens, and a direct action day on 10th September.
There will be a press conference, with all media welcome, about the arms fair and the protests against it at 10.30am on Friday 5th September, at Friends House, Euston Road (opposite Euston rail station).
For more information, images and interviews contact: The Press Office, Campaign Against Arms Trade Tel. 020 7281 0297, Email: media(at)caat·org·uk, Out of hours: 07092 230 477


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The Bluecheese Wonder Room
The Bluecheese Wonder Room: 2/14 - 2/22
Farewell, Metta. Stay, Melo.
By bluecheese999 Feb 24, 2014, 11:38am EST
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Goodbye Metta World Peace. In a crazy week that saw Tim Hardaway and Carmelo Anthony put up incredible scoring performances over All-Star Weekend and Iman Shumpert and Raymond Felton somehow remain with the Knicks past the trade deadline, Metta's departure stands out as an unquestionable lowlight. After all, this is a man who gave us the headline Metta World Peace's favorite meal is beans. It's fitting that Metta's final game as a Knick came against the Magic, considering the highlight of his Knicks career: On December 6, 2013 World Peace was a +39 in the Knicks 121-83 win over the Magic, the highest +/- by a reserve in Knicks history! We'll miss you in New York, Metta. Please don't sign with the Heat.
Player of the Week - Carmelo Anthony
I'm a very selfish person. Over the past couple of weeks I've seen numerous comments begging Melo to leave because we all know he deserves to get away from Dolan's toxicity. But I'm going to ask the exact opposite. Please, please, please stay! Unlike Melo, I can't just sign a $100 million contract and suddenly be free of the Knicks. I'm stuck with this team for life. This year has been an unmitigated disaster, but watching Anthony play has been one of the few bright spots. I just don't think I'd be able to handle him draining 16-footers for another team while the Knicks circle the drain for the next decade.
Carmelo began the week by scoring 30 in the All-Star game, while setting a record with 8 three pointers made. Then came the brutal 4 games in 5 nights post-All Star Break stretch, in which he averaged 35.8 PPG and 7.5 RPG, while shooting 51% from the field. In the process, he became the first Knick with 42+ points in consecutive games since Bernard King in 1984. Most impressive of all, with a jumper early in the fourth quarter against Memphis, Anthony passed Eddie Johnson to move into the top 50 on the all-time scoring list. If he maintains his 27.9 PPG over the final 25 games of this season, it'll put him at 20,024 career points. If we do happen to fall out of the playoff chase, and sadly it's looking more likely every day, maybe Melo's chase for 20,000 points can give us a bit of excitement.
Opposing Player of the Week - Mike Scott
On December 1st, Ryan Anderson was 7-11 from three point range en route to 31 points. Just under two weeks later, Louis Williams shot 6-13 for three in a 27 point effort. Two days after that, it was Martell Webster's turn. He shot 6-8 from downtown and scored 30. A little less than two months later, Jimmer Fredette came to the Garden and buried 6-8 triples as part of a career-high 24 point night. Finally on Saturday, it was Mike Scott's turn to go nuts, as he went 6-7 from three and scored a career-high 30 points. If I still remember basic math, that means that this season, the Knicks have allowed five separate bench players to hit six three-pointers in one game. Before this year, they had never allowed more than two players to do that in a season. In fact, it hadn't even been done against the Knicks by a player not named Alan Anderson in five years, when our old friend Steve Novak hit six threes for the Clippers. Do we have an acronym for allowing bench players to hit a bunch of threes in one game? (Uhhh...Knicks' Inferior Defense Allows Second-Stringer A Lot Of Threes? KIDASSALOT? -Seth)
Tim Hardaway Jr. is better than his father and Kobe Bryant
Tim Hardaway Sr. had a great rookie season. He averaged 14.7 points and 8.7 assists en route to a spot on the All-Rookie first team. On January 8, 1990, he had an incredible triple-double, with 19 points, 19 assists, and 10 rebounds. Kobe Bryant's rookie year wasn't quite as good, but he did have a few highlights, as he won the slam dunk contest and set a then-record with 31 points in the rookie game. Yet despite these performances, both men have been outshined by a young Knicks guard. With 36 points in New Orleans last Friday night, Tim Hardaway Jr. had more points in one rookie game performance than Kobe Bryant and Tim Hardaway Sr. combined!
Bluecheese's Rambling Stat of the Week - (WARNING! May not end in a coherent thought)
Tyson Chandler had 23 rebounds in the Knicks loss to the Hawks on Saturday night. The last Knick with at least 23 boards was Chandler, when he had 28 on February 27, 2013. Stephen Curry scored 54 points against the Knicks that night, while playing all 48 minutes. The last player before Curry to play all 48 minutes and score at least 54 points in a loss was Lebron James on March 20, 2005. The opponent's leading scorer in that game was Jalen Rose with 30 points. Rose and his father, Jimmy Walker, are 1 of 3 father-son duos to score 30 points in a game against the Knicks, the other 2 being Dell and Stephen Curry and Mike Dunleavy Sr. and Jr. (who else?). Mike Dunleavy Sr. made the NBA Finals as a rookie coach in 1991, where his Lakers lost to Michael Jordan and the Bulls. Jordan is one of three NBA players to score at least 54 points as an opponent in the current MSG, the other two being Stephen Curry and Kobe Bryant. Kobe Bryant scored 58 points on December 29, 2006, the last NBA game in which one player scored at least 50 points and another had at least 25 rebounds until February 27, 2013, when Curry had 54 and Chandler had 28, when he became the last Knick with 23+ bounds in a game...until he did it again on Saturday!
Last Week in Jared Jeffries History
On February 18, 2010 the Jeffries was traded from the Knicks to the Rockets as part of a three-team deal the netted the Knicks Tracy McGrady and Sergio Rodriguez. Those two paid dividends immediately. In his second game as a Knick, Rodriguez had 8 steals, becoming the first Knick was that many in a game since Chris McNealy in March 1986. Meanwhile, T-Mac scored 26 points in his debut and had the Garden crowd chanting his name. It was short-lived, but for a brief moment, it seemed like Rodriguez and McGrady could help lead the Knicks back from the brink of despair for the first time in years.
Last Week in Jared Jeffries Shot Tracker History
The Knicks Did it First
There were a few non-Knicks stats that would have been fairly impressive last week, had the Knicks not accomplished them first:
1. On Saturday, Anthony Morrow was 7-8 from the field, including 3-3 from three point range, for 18 points in the Pelicans 94-93 loss at Washington. The last two people before Morrow with those exact numbers in a road game: Landry Fields, in a win in Atlanta on April 22, 2012, and Charlie Ward, in a win in Toronto on January 17, 1998, both as members of the Knicks.
2. On Friday, Anthony Tolliver was 3-3 from the field, all of which were three pointers, in 17 minutes played, in the Bobcats 90-87 win over the Pelicans. The last player before Tolliver to go 3-3 from the field, all three pointers, while playing no more than 17 minutes in a win: Steve Novak, who did it in 15 minutes in a 95-82 victory over the Hawks on April 3, 2013.
3. On Thursday, the Heat played their 53rd game of the season, beating the Thunder in Oklahoma City 103-81. The last team before Miami to win by exactly 22 on the road in their 53rd game of the season: the '96-'97 Knicks, who beat the Kings in Sacramento 109-87. Like this year's Heat team, after 53 games the '96-'97 Knicks were also 39-14.
4. On Wednesday, Kevin Love had 42 points and 16 rebounds to a 104-91 win over the Pacers. The last two times a player before Love had exactly 42 & 16 in one game: January 13, 1994 and January 10, 1991, both times by Patrick Ewing.
5. On Tuesday, the Cavaliers beat the 76ers 114-85. The last Eastern team before Cleveland to win 114-85 on the road: the Knicks, who beat the Providence Steam Rollers by that score on December 6, 1947. The Knicks were led that night by Carl Braun, who scored 47 points.
Movie of the Week - Space Jam
This week ranked among the more difficult ones. The win over New Orleans was nice, but it was surrounded by bad losses to Memphis, Orlando, and Atlanta. Metta and Beno are gone, while Woodson and Felton somehow managed to stick around. But worst of all was the news that there was a Space Jam 2 starring Lebron James in the works. Fortunately, the rumor was debunked and we can all breathe a sigh of relief.
Since we all spend approximately 10 hours a week watching nightmarish Knicks games, I think every one of us could use some entertainment. Here is a list of my 53 favorite movies (in alphabetical order). I hope you refer to this list when deciding what to watch when you're not tearing your eyes out watching inept basketball.
21 Grams, The 40 Year Old Virgin, American Beauty, American History X, Anchorman, Anchorman 2, Animal House, Batman Begins, Battle Royale, Bicycle Thieves, Borat, Caddyshack, Casablanca, Casino Royale, The Dark Knight, The Dark Knight Rises, Die Hard, Donnie Darko, Dumb & Dumber, Eternal Sunshine of the Spotless Mind, Fargo. Fight Club, The Godfather, The Godfather: Part II, The Good, the Bad and the Ugly, Goodfellas, Gravity, The Hangover, Hotel Rwanda, The Impossible, Inception, Inglourious Basterds, Léon: The Professional, The Lion King, Lost in Translation, The Matrix, Mulholland Dr., Pan's Labyrinth, Psycho, Pulp Fiction, Requiem for a Dream, Reservoir Dogs, Schindler's List, Se7en, The Shawshank Redemption, The Silence of the Lambs, Space Jam, True Romance, Twelve Monkeys, The Usual Suspects, V for Vendetta, Winter's Bone, Zero Dark Thirty.


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Gsky Gs 28usb driver direct download was reported as adequate by a large percentage of our reporters, so it should be good to gxky and install. Learn More – opens in a new window gsky gs 28usb tab. Refer to eBay Return policy for more details. Please enter a number less than or equal to 1.
For additional information, see the Global Shipping Program terms and conditions gksy opens in a new window or tab Gsky gs 28usb amount includes applicable customs duties, taxes, brokerage and other fees. This item can be sent to United Statesbut the seller has not specified postage options.


I thought I'd show you round my studio today, or in other words 'my room of random requirement'. At the moment it's full of flowers as I'm busy making up little arrangements for my local gift shop in Woburn. But I also use it to paint in, do craft and just sit with a cuppa.
It's furnished with vintage finds and hand me downs. The blue drinks cabinet and dresser came from my local house clearance barn, my chair came from my husbands parents and my makeshift table is scaffold boards given to us by my neighbor. My handmade easel was made for me by my grandfather for my 21st birthday (many moons ago).
Hope you enjoyed looking round.


Thoughts and Musings by Duke Lancaster: Welcome!
I have been told that I am a 'frustrated writer'. I tend to rant and rave on many issues via email... so rather than take it out on my friends I thought I might try elaborating on my thoughts and musings in a blogger context.
I am simply using this first blog to initialize the blog site but I will get more detailed soon. Thank you for visiting. I hope you find something here among my ramblings that is helpful... or at least relevant enough to make you think.


text:
Q: How to add attributes to a active record result in Rails 4? Lets say that I have a model with name of User. How can I add a virtual attributes to the final result of generated query ?
class User < ActiveRecord::Base
  ATTRIBUTES = %w[name email balance]
  scope :main_selection, -> { select('name,email,total_bought, total_deposit') }

  def balance
     (total_deposit - total_bought).round
  end
end

and inside my controller I have
@user = User.main_selection
@attributes = User::ATTRIBUTES

Inside the View I would like to show it in a table

   <% @attributes.each do |a| %>
    <%= a %>
   <% end %>

  <% @user.each do |u| %>

    <% @attributes.each do |a| %>
     <%= u[a] %>
    <% end %>

  <% end %>

The only problem is that I need to add the balance attribute into the generated result, so that the loop with u[a] could work.
I need to mention that the balance can be called by @user.first.balance, but inside the loop does not work and it shows a nil value instead.

A: Try u.send(a) instead of u[a]
u[a] will only work on attributes. In your example, balance is not an attribute, it's a method.

redpajama_set_name: RedPajamaStackExchange


Cake makes the world a better place and enhances the spirit of every celebration. They are perfect to spread happiness, congratulate loved ones, and make someone special smile and relish their taste buds in a delightful manner. Choose from our delectable range of truffle cake, kit kat cake, red velvet cake, and rich fruit cake to offer your dear ones in Ludhiana on their special occasions.
Purchasing cakes online has its own benefits. You can shop at any time you please, spend less money and also get to choose from a much wider variety. And the entire responsibility of delivering the cake is shouldered by the e-commerce site selling the cake. For buying cakes online, you can count on us for quality, variety and price. We leave no stone unturned to ascertain that our customers only get the best. So, once you place the order, we make sure the cake is dispatched only a short while after it has been made, so that it is still fresh when it reaches you. Also, we help you in cake delivery in Ludhiana online in the shortest possible time via one of our fast delivery services including for same day & midnight deliveries. Black forest cakes online delivery or delivery of any other flavour to Ludhiana takes only about a few hours.
To guarantee timely and careful delivery of the products, we have designed different modes of delivery. Our range of express delivery services meets the different types of requirements on our customer's ends. You can get online cake delivery in Ludhiana at your convenience by providing us with a fixed time for delivery. Or we can also make birthdays and anniversaries more special by delivering the cake at midnight if you choose to. Cakes delivery in Ludhiana is also done very carefully, so that no damage is caused while transporting the product.
You can also send cakes to Delhi online for free as we offer free shipping and free home delivery for our products. This allows you to ensure more savings, and us to remain at the top of your list when it comes to shopping for cakes online.
How can you send cakes to a specific location in Ludhiana?
Online portal like Ferns N Petals can do assured cake delivery in Ludhiana to the location of your choice.


The snow is finally gone. The cold temperatures and frost warnings have gone away and the garden is in! Spring is in full swing at the farm – Finally!!! So we thought for today's Sunday update – we would simply take a tour around the farm in photos – and let you see what is growing. We hope you enjoy!
The girls are doing their early morning work of laying eggs – and not too happy about being interrupted for a picture.
The strawberries are forming – we should actually get a decent crop from them this year.
The little clusters of grapes are forming on the vines – this will be our first year to get a few from the vines!
We made these signs from 6 x 6 posts and left over 2×4 lumber – they line the driveway and hold planters or lanterns on the other side.
The crisp stalks of onions in the early morning dew.
A view up the hill from the back of the garden.
The cabbage plants are looking healthy as well.
A little excitement at the farm – The local Fox/ABC station and morning show personality Dana Turtle visited this week and broadcast from the farm.
Dana poses for a picture with us.
We hope you enjoyed – Mary And Jim!
← Red, White, And Blue Salsa Recipe – Just In Time For Your Picnic!


RISE AGAINST CELEBRATES RECORD STORE DAY!
Fat Wreck put us on the map, and "Join The Ranks" was the very first song we ever officially released on a proper label. "Gethsemane" was recorded in an old oil factory in Chicago, the same factory where we would go on to film our first video. Along with "Generation Lost", this seven inch is long overdue and we're happy to team up with our old friends at Fat to do it.


As you can see, the "cruel and unusual" clause applies not only to the death penalty, but to all types of legal punishment. Sentencing a person to death as punishment is not unusual — governments and leaders have been executing people for centuries — but in the United States, people question at what point a punishment becomes cruel or unusual.
Some people believe that taking another person's life — whether it's by a government or an individual — is by definition cruel and should therefore be banned. Those who don't oppose the death penalty see "cruel and unusual" in a different light, believing that as long as the person being executed doesn't suffer, it satisfies the Constitutional requirements.
In the United States, felons are normally executed in one of two ways: lethal injection or the electric chair, with lethal injection being the most common. It makes sense, too, because lethal injection inflicts the least pain, first putting the condemned to sleep, then stopping his breathing, and then stopping his heart.
Other execution methods have been used in the past, including the gas chamber, firing squad, and hanging.


The next Automatic Data Processing Inc. dividend will go ex in 2 months for 79c and will be paid in 2 months.
The last Automatic Data Processing Inc. dividend was 79c and it went ex 2 months ago and it was paid 21 days ago.
How accurate are our Automatic Data Processing Inc. forecasts?


text:
Borat Journalist Exchange Program: Epilogue
Todd Lassawriter
No word on how Car No. 22, one of the two American teams, did. Mercedes-Benz finished its E320 diesel run from Paris to Beijing just in time for the Beijing Motor Show, and reports the 36 cars averaged 8.32 liters of low-sulfur diesel per 100 kilometers. Makes me feel better about our run through Kazakhstan in Car No. 22.
Yes, I know, my daily blogs went back and forth on whether there were 33 cars or 36. I think the translation from German to English confused some of us. The deal is this - Mercedes sent out more than 360 drivers from 35 countries in 36 cars. Three of the cars were E320 Bluetec diesels, including No. 22. The other 33 were conventional E320 CDIs. Half of the 36 were 4Matics and the other half, including ours, had rear-wheel-drive. Mercedes says the RWD models averaged 8.01 liters per 100, while the 4Matics averaged 8.53 liters.
While a Polish team seemed to be running the best numbers from Ekaterinburg, Russia, to Almaty, Kazakhstan, Mercedes says the winner was the eBay team (probably entailed some bidding), which averaged 7.19 liters per 100 kilometers. The "German Taxi" team had the best one-day run, 5.5 liters per 100, from Lanzhou to Wuhai, China. Benz says that altogether, we used 40,530 liters of low-sulfur diesel, about 10,000 less than it had expected.
The 36 E320s, plus 24 escort vehicles rang up a total of 840,000 kilometers. And the Paris taxi team, which ran the meter from start to finish, rang up a bill of nearly 40,000 euro, or $51,288.79, which will buy you a nicely equipped E320.


text:
is a passenger railway station located in the city of Isumi, Chiba Prefecture Japan, operated by the East Japan Railway Company (JR East).

Lines
Chōjamachi Station is served by the Sotobō Line, and is located  from the official starting point of the line at Chiba Station.

Station layout
The station consists of a single island platform connected to a white-washed station building by a footbridge. The station is staffed.

Platform

History
Chōjamachi Station was opened on 13 December 1899 as a station on the Bōsō Railway. On 1 September 1907, the Bōsō Railway was nationalized and became part of the Japanese Government Railways, which was transformed into the Japan National Railways (JNR) after World War II. Freight operations were discontinued on 1 October 1962. The station was absorbed into the JR East network upon the privatization of the Japan National Railways on 1 April 1987.

Passenger statistics
In fiscal 2019, the station was used by an average of 334 passengers daily (boarding passengers only).

Surrounding area

 former Misakipachi town hall

See also
 List of railway stations in Japan

References

External links

 JR East Station information

Railway stations in Japan opened in 1899
Railway stations in Chiba Prefecture
Sotobō Line
Isumi


text:
Messages from the Past on Ticknall Pottery
27 June 2019 2 September 2019 Janet Spavold
We all know about having a special mug with a design that really means something to its owner. A football club's logo is perhaps the commonest example these days, so you can show the world who you support. Football clubs inspire intense, often lifelong, loyalty through good times and bad. They generate a sense of belonging within their communities and their followers will travel all over to support their team.
We might think it's a cultural phenomenon peculiar to modern times, and so far as football is concerned, that's right; the club loyalties really only developed after the structure of Association Football was formalised. But that need to have something tangible to identify with, to belong to a like-minded group, was just as strong in the late 1400s and early 1500. At the time there were seven or eight potteries in Ticknall, and someone here with a good marketing sense picked up on this trend. We don't know who came up with the idea first, but we do know that once one potter had shown there was a market niche, the others copied him, and a whole new line of pottery began.
Round about 1450 a new type of finely potted tableware began to replace wooden cups. It was called Cistercian Ware because the first archaeologists to recognise it found so much on Cistercian monastic sites that they mistakenly thought it was made there. They were mainly cups with two or three handles, often with a rounded body and a tall flared rim. They were not made only in Ticknall – other sites making them were at Wrenthorpe near Wakefield, Chilvers Coton, and Potterton near Leeds. Where Ticknall scored was that our potters decorated their cups with unique designs that tapped into the mood of the times.
Cistercian cups were made at a time of intense personal Christian devotion. It would have meant a lot to the people who bought the pottery to have individual reminders of their faith in everyday use. They wanted to see the same visual representations of key aspects of Christian faith that they saw in church in stained glass, wood carvings, wall paintings and manuscript illustrations in the big Bibles used in church services. The decorative sprigs on the pottery may be made quite crudely but they are recognisably the common religious symbols from the time (1450 – 1550). People could show their personal devotion to their faith through their choice of designs, in much the same way as football supporters do today.
The Ticknall Archaeological Research Group has been able to dig on a number of ex-pottery sites, and we are very grateful to the site owners for permission to run digs. As a result we have found thousands of fragments of Cisterican cups and other vessels. They are all damaged in some way – what we find is the stuff that went wrong during firing, and was thrown on the tip as unsaleable. We rarely find a complete cup.
Here are some of the designs on the cups and what they meant to their owners, starting at the top with God who was represented by the sun. There are three versions of suns.
Jesus Christ comes next. His name in Latin was Jhesu Christu, and in those days the letters I and J were interchangeable. On the cups, his name was abbreviated to IHC. The fish was a general symbol for Christianity (as it still is).
The cross reminded people of Christ's sacrifice to save them. Our potters used four different kinds of cross: a Greek cross, a Latin cross, a Jerusalem cross and a consecration cross.
The acanthus leaf also represented Christ, because the crown of thorns was made from the spiny acanthus. We find three versions of it, and it's by far the commonest symbol on the Ticknall cups.
The Virgin Mary was represented by a rose; she was the centre of a general cult of personal devotion because she could help ordinary sinners by asking for mercy on their behalf.
The wheel represented the wheel of eternity – it was meant to remind you that however you behave in this life will be reflected in the next. The good will go to eternal joy in heaven, while the bad will suffer the eternal tortures of hell. There were three types of wheels, and they were the next most common symbol on the Ticknall cups.
The Holy Trinity occasionally made an appearance on the pots, in the form of three equal circles placed as a triangle.
One of our potters also thought about the key features of the Mass, and put the bread and wine on some of his cups in the form of the Communion wafer and a bunch of grapes for the wine.
The potters were quite artistic in their designs, which were not confined to religious motifs. When Catholic symbols were outlawed under King Edward VI, our potters made cups with naturalistic designs to try to save their lucrative trade. Here are some flower and leaf designs.
One of our potters did a series of animal designs which are so well made that you can even see the claws on the dog. He did a bull and a pig too, as well as the fish.
You can see the pottery at any of TARG's displays or talks.
But their efforts to save the Cistercian trade failed, and the cups disappear at around 1550.
Latest posts by Janet Spavold (see all)
History of Ticknall - 9 October 2015
Messages from the Past on Ticknall Pottery - 27 June 2019
You might also like . . .
History of Ticknall
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← Everything's coming up roses
Genealogy – Local Resources →


text:
REPORT: Manny Ramirez Suspended For Sexual Enhancement Drug
Written By smokey fontaine
From Yahoo Sports
A source close to Manny Ramirez(notes) said Thursday that the illegal substance for which the Los Angeles Dodgers slugger tested positive was not "an agent customarily used for performance enhancing."
At least not on the baseball diamond. The source, who spoke on condition of anonymity, was prescribed to address Ramirez's erectile dysfunction.
However, two sources said the substance Ramirez tested positive for a gonadotropin. Major League baseball's list of banned substances includes the gonadotropins LH and HCG, which are most commonly used by women as fertility drugs. They also can be used to trigger testosterone production. Testosterone is depleted by steroid use, and low testosterone can cause erectile dysfunction.
"Testosterone and similar drugs are effective for erectile dysfunction in that they jazz up your sex drive," said Charles Yesalis, a professor at Penn State who has testified before Congress on issues of performance-enhancing drugs. "But far more clinicians accept that affect with Viagra and Cialis. It's hard for me to understand if it was erectile dysfunction why they would use it."
Baseball Should Always Come Secondary To Family
Sharpton, Leaders Deliver Black Agenda For Obama's Second Term
The "Minority Majority" & The Data Set of Election 2012


text:
Q: Python AttributeError: module 'x.y' has no attribute 'z' I'm seeing some strange behavior with some python imports:
Here are the commands I run:
import x
x.y.z
> AttributeError: module 'x.y' has no attribute 'z'
from x.y import z
kola_core.utils.node_utils
> < No Error >

Why must I explicitly import 'z' from 'x.y'?
This is the file strucutre:
x
--__init__.py
--y
  --__init__.py
  --z.py


-That is not all! There are many other areas that OT can address.
Students in OT sessions perform activities for successful skill development. For example, a student working on fine motor skills may perform extra paper and pencil activities.
Activities performed in OT for skill acquisition are purposeful and meaningful. The activities are purposeful because they are chosen to have a direct association with skills needed to live life day to day. For example, handwriting is often a major focus of OT sessions. In order to keep up with learning in class, students must write efficiently. Handwriting is a "skill" for the "job" of being a student. Lastly, the activities are chosen to be meaningful to each individual student. So, if a student really loves dinosaurs, we do our best to include that in our sessions. So, for example, if the student that loves dinosaurs is working on handwriting, we could do warm-up exercises for the wrist and hands like a T-rex.
Occupational therapy is provided individually or in a small group in the OT room, in the classroom, and in other school settings. Please use the contact information below to touch base with OT at Collier, whether it is with questions, comments, or to ask for resources.


Are there any laptops on APU Ryzen with FreeSync support display?
I heard that HP intend to release laptops on the basis of APU Ryzen with FreeSync support display.
Have you seen such laptops from any manufacturer on sale?
I saw numerous laptops with Ryzen/Vega setups at HP and Dell sites. If you are interested in one fire off a question to their tech support to find out if it supports FreeSync internally and or externally. I didn't see it listed in any capacity on either site.
I know all laptops with Ryzen/Vega APU at HP, Dell, Lenovo and Acer, but tech support from this vendor is unsuccessful.
Googled AMD LAPTOP WITH FREESYNC and found this website: https://www.windowscentral.com/best-freesync-laptops (2017) .
According to another website, HP says it will make all of it laptops with freesync in the future: HP to put FreeSync in all their AMD-based laptops - TechSpot . (2016).
I have already studied all this information, as well as requested the support of all APU Ryzen laptop manufacturers, but the answer to my question hasn't received yet.
Therefore, the above question was asked here.


If your name does not appear in this Voter Lookup database, you may not be registered to vote. Contact your county election commission to verify if you are registered to vote, or learn how you can register to vote in Tennessee.
Zoom in on the area where you live on the Senate Districts map, and then click the map and your district number will be displayed. If you prefer, you can type in your street address to discover your Senate district.
Scroll down the page, zoom in on the area where you live on the House Districts map, click on the map and your district number will be displayed. Alternately, you can type in your street address to locate your House district.


text:
How to Cop the Yeezy 450 "Dark ...
Image via yankeekicks
How to Cop the Yeezy 450 "Dark Slate" Restock
Yeezy450
By Adam Cheung • Head of News & Creative • 01 Dec, 2021 3:25 PM
Following the "Cloud White" restock that plenty of you managed to cop, the equally-as-iconic Yeezy 450 "Dark Slate" is now set to return as well. Affectionately nicknamed the "Burnt Dumpling" by many sneakerheads, this "Triple Black" trainer originally released back in June and is still a must-buy for many of you.
First teased by Ye all the way back in 2018, the shark tooth-inspired Yeezy is the brainchild of legendary designer Steven Smith. Using a selection of straight edges and voluptuous curves, the result is an extremely experimental silhouette that is unlike anything the sneaker world has seen before. With a sock-like Primeknit upper that mimics the 350 V2 and a spiky EVA midsole underfoot, this is an adidas shoe like no other.
If you need the adidas Yeezy 450 "Dark Slate" in your winter rotation then you're in luck, as it's set to get a major restock this month. If you're brave enough to rock Ye's latest sneaker, then we've got your back, as we've compiled a few tips and tricks on how you can maximise your chances of getting a W!
Raffle Guide
Need the Yeezy 450 "Black" in your collection this season? Then the first thing that you need to do is follow us over on Twitter. By following @thesolesupplier, we'll update you on the latest news surrounding the release, while @thesolerestocks will keep you locked in with direct links and potential restock information as well.
No raffles have been announced for the "Dark Slate" just yet, but as soon as they do those Twitter accounts will inform you and they'll be posted right here. We predict that there won't be too many though, so to increase your chances you can try and enter with multiple accounts. With that said, it's worth noting that some retailers will take money off you first so make sure you have enough cash in the bank. This is a completely normal procedure and it's been implemented to prevent bots from applying too many times.
If you didn't already know, the adidas Yeezy 450 "Dark Slate" will be launching through adidas CONFIRMED and will restock sometime in December. If you don't already have it, then make sure you download the adidas CONFIRMED app on your phone right now! After a long hiatus, the beloved Three Stripes platform is back, and it's the best way to cop some of the world's most exclusive releases.
As soon as you have it on your phone, log in, verify your account, and enable push notifications and location services. It's worth noting that if you change any of these requirements after participating in a draw, it will lower your chances of winning - just a heads up!
If there's one thing that we just can't stress enough, it's how important it is to have all your payment and address info saved and verified. Better yet, let your bank know that it's actually you who's making the transaction just so they don't put it on hold.
Instagram Raffles
If at this stage you still haven't copped, don't worry, as we've got another pretty good tip for you. Load up Instagram right now and follow every single retailer that sold the "Dark Slate" 450 as they're known to re-raffle unclaimed pairs. This happens with the majority of hyped drops, so there's a huge chance that you'll be able to cop here.
If that doesn't work out, then you've got two more options. You can either go on StockX and get a pair sent straight to your door, or head on over to The Sole Supplier's dedicated Buy & Sell Group on Facebook where you can buy, sell, and even exchange trainers for the pair you want. You probably won't get them for retail here but we've got some pretty good and honest members so don't be surprised if you do.
And that's that! If you follow every single one of these steps, you've got a pretty good chance of copping the adidas Yeezy 450 "Dark Slate" this month! Again, it will re-release in December, so make sure you keep it locked at The Sole Supplier for your best chance to cop. If you're not sure what size to get, take a look at our handy size guide here!
The Air Jordan 1 Retro High OG "Marina Blue" Is This Week's Hottest Release!
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