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THOUGHT FOR THE DAY!
"I did not have sex with that woman [Monica Lewinsky]." -- Bill Clinton.
YOUR RANDOM DHS MONITORED PHRASE OF THE DAY
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May 01 21:08
Musk tweets he's selling almost all his physical possessions... Knocks $14 billion off TESLA value
Icke Banned By Fascist Facebook - The Little Boy Gofer For Global Tyranny - David Icke Dot Connector
By: malterwitty
Thousands Amass in Front of Huntington Beach Pier to Protest Newsom's Order to Close Orange County Beaches (VIDEO)
By: neha1985
Crazed Democrat Governor Gavin Newsom on Thursday retaliated against the citizens of his state and closed all beaches in Orange County amid the Coronavirus panic.
AG Barr: It's Time to Roll Back Coronavirus Restrictions Imposed by State and Local Governments (VIDEO)
US Attorney General Bill Barr on Friday said it's time to start rolling back Coronavirus restrictions imposed by state and local governments.
exmarketplace 2
Coronavirus Totals - Lockdown vs No Lockdown
Locked down:
Population is estimated at 331,002,651. The population density is 36 people per Km 2
Infections: 1,130,851
Deaths: 65,729
Population is estimated at 63,182,000. Population density is 259 people per Km 2
Infections: 178,566
Not locked down:
Population is estimated at 10,099,265. Population density is 25 people per Km 2
Infections: 21,520
Deaths: 2,653
Population is estimated at 9,449,323. Population density is 47 people per Km 2
Population is estimated at 126,476,461. Population density is 347 people per Km 2. Tokyo's population is estimated at 37,393,129 with a density of 6,224 people per Km 2
Deaths: 430
So why the lock downs? Tucker Carlson eloquently explains:
"High-Risk" Convicted Child Molester Rearrested For Sex Crimes After Controversial Release From California Jail Due to COVID-19
Rudy William Grajeda Magdaleno, 39, was one of the seven "high-risk" sex offenders and child molesters released from a prison in Orange County by Court Commissioner Joseph Dane due to the Coronavirus.
Magdaleno was rearrested on sex crimes this week just two weeks after he was released from prison in Orange County.
Kellyanne Conway Drops a BOMB — Implicates Obama in Oval Office Scheme to Destroy Trump (VIDEO)
Former Trump campaign manager and current Consultant to President Trump, Kellyanne Conway, joined America's Newsroom on Friday morning to discuss the recent allegations against the Obama administration and their active spying on the Trump Campaign and Transition Team for political reasons.
Is there any science behind two-metre social distancing rule…? Government adviser says guidelines on keeping apart was 'conjured out of nowhere'
Bill Gates: Test Tube Meat, Mandatory Vaccinations & Real Time Global Surveillance From Space
By: ActivistPost
By Spiro Skouras
By now it is no secret the World Health Organization and the United Nations are among the many organizations funded by the Bill and Melinda Gates Foundation.
In previous reports we have extensively documented Gates' global vaccination programs and their connections to the UN's Sustainable Development Goals under the 2030 Agenda.
In this report, we document how Bill Gates is not only working to fulfill the UN's global vaccine program, but how Gates is also working to take control of the food supply chain globally, a long-desired achievement of the UN.
Also find out about the mandatory vaccination policy being kept under wraps in addition to another Gates-funded venture to blanket the earth with real-time surveillance from space.
This is a liquidity trap. There will be a run on the market
Let's put a price tag on that Fleet Week Blue Angels show
The budget for 2016 is $35,475,000. This year, according to the Angels' schedule, they will perform 56 demonstrations (32 show weekends, but not all are two-day events). That's counting two-day shows like SF Fleet Week as two demonstrations, for those taking notes.
Now, that budget includes 46 practice sessions back at Naval Air Station Pensacola, plus travel to and from all the shows, fuel, maintenance, and pretty much all the costs specifically associated with the Blue Angels program (which, by the way, falls under the recruiting and advertising portion of the budget.
With a quick calculation, I come up with a per-demonstration cost of $633,482.14. That means that, for this year's upcoming show, including practice and two demonstrations, the cost is somewhere north of $1.26 million.
Michigan Legislature Moves to Block Whitmer's Shutdown Extension, Prepares to Sue
Global energy demand is set to fall 6% in 2020, seven times greater than the drop in the wake of the financial crisis.
Empire, Fiat Money, And Socialism Are Rapidly Falling Apart... Individual Liberty Is In Need of A Renaissance
RED ALERT: President Trump "pivots to mandatory vaccinations," jumps in with Big Pharma's diabolical "warp speed" mass medical experiment on the American people
By: Tian Shan
COVER-UP/DECEPTIONS/PROPAGANDA
Youtubes Chief Product Officer Disrespects Independent Creators
Yes..The (((Fed))). Has A "DARK" SECRET That You Are NOT Supposed To Know About. And It's A Second Balance Sheet On The Side
Listen to this...and let it sink in. Chicago will be the first to undergo Mass Vaccination.
Coronavirus vaccine: Moderna signs deal for 1 billion Covid-19 doses a year
By: unewsy
Moderna announced a global agreement under which Lonza Group will ramp up output of the proposed vaccine, which is based on a novel technology that relies on genetic material called mRNA. They expect the first batches to be produced in the US in July
Coronavirus: Cyber-spies seek coronavirus vaccine secrets
Bill Evanina, director of the National Counterintelligence and Security Center, said the US government had warned medical research organisations of the risks.
Freudian slip by Dr. Birx during CNN interview....
By: newsguy76
Bill "The Rapist" Clinton Wants Army of Coronavirus "Contact Tracers" To Track All Americans
30 million people have filed for unemployment in the last 6 weeks, equal to *every single worker* losing their job in these 27 states
VIDEO: "Convincing evidence": Trump says he's SEEN info COVID-19 originated at LAB in WUHAN
Biden FINALLY Addresses Accusation But Gets CAUGHT LYING, MSNBC Presses Him And He Just Melts Down
Joe Biden and Hillary Look LOST on Own Livestream PROVING They Know NOTHING about Technology
TAIWAN: No Lockdowns, No Closed Businesses, Non-WHO Member, And Relatively Unaffected By COVID-19
Johns Hopkins University had predicted that Taiwan would have the second most COVID-19 cases in the world, due to its close proximity to Mainland China.
But astonishingly, in spite of being only 80 miles from the coast of China with over 400,000 of its 24 million citizens working in China, as of mid-April, the country only had 400 cases of COVID-19, and only 6 deaths. And the vast majority of their 400 cases came into the country from abroad.
All of this has happened without shutting down the country with lock downs, and with almost all of its businesses continuing to operate.
Plastic purge: Britain's personal debt pile SHRANK in March as people shun credit cards amid coronavirus crisis
Households paid back a whopping £3.8billion more debt than they borrowed in March 2020, the biggest figure on record, as households shunned credit cards in the face of the coronavirus crisis.
Britain's credit card debt pile shrank £2.4billion in a month to £69.3billion, only the second time since July 2013 the amount Britons have outstanding on plastic has fallen, according to the Bank of England figures.
The amount of debt held on credit cards was lower than the same month the year before for the first time since it began recording the data in 2008, it adds.
Lockerdome
Kellyanne Conway Drops a BOMB — Implicates Obama in Oval Office Scheme to Destroy Trump
It is now clear that the Obama administration went after General Michael Flynn for over a year before the 2016 election and was spying on the Trump campaign for months to gain a political advantage.
The mainstream media to this day continues to ignore or downplay this biggest political scandal in US history.
Global smartphone sales show the 'biggest decline ever' in the first quarter of 2020 as production and consumer demand slump during the coronavirus lockdown
In the first quarter of the year – from January 1 to April 30 – there were 274.4 smartphone units shipped to customers – down from 329.9 million for the first quarter of 2019, the firm said.
Nine of the world's top 10 equipment manufacturers suffered declines in device shipments – Samsung, Huawei, Apple, Xiaomi, Oppo, Vivo, Motorola, LG and Chinese seller Tecno.
The global smartphone market is now set to fall by 13.1 per cent this year, with around 1.2 billion units sold in 2020 compared with 1.39 in 2019, Omdia said.
IDC, another independent analyst firm, has said that this quarter's global decline in smartphone shipments is the biggest ever.
Britain's manufacturers suffer worst drop in output and employment since records began nearly 30 years ago - outstripping the figures seen during the global financial crisis
As the economic toll of lockdown starts to rear its ugly head, employment, new orders and output in the sector fell at the fastest pace for 28 years last month.
The closely-watched IHS Markit/CIPS purchasing managers' index fell to a record low of 32.6 in April, down from 47.8 in March, with a reading of 50 or above indicating growth.
April's manufacturing PMI reading of 32.6 is even worse than the previous record low of 34.5 recorded during the heat of the global financial crisis in 2009.
Boots installs safe spaces inside its pharmacies for victims of domestic abuse as cases surge by nearly 50% during lockdown
US PEACE PRIZECALL FOR NOMINATIONSExtended to May 31
I hope that you and your family are safe and healthy. Given this unprecedented pandemic, our Board of Directors has decided to extend the nomination period for the 2020 US Peace Prize until May 31.
Founding Members are invited to submit nominations for the US Peace Prize. The US Peace Memorial Foundation awards this honor each year to a deserving American or U.S. organization.
It does not make sense.(Picture)
Coronavirus homeschooling: 77 percent of parents agree teachers should be paid more after teaching own kids, study says
Good teachers change lives for the better – and nearly 80 percent of parents agree that educators deserve a major raise, after taking charge of their children's schooling at home amid the coronavirus pandemic, a new study claims.
Showdown! Pelosi Talking About $1 Trillion For Cities & States In Next Coronavirus Fiscal Stimulus!
Photographer Takes Pics Of People In Public From 2 Perspectives And It Shows How Easily The Media Can Manipulate Reality
Everyone knows that reality is subjective. Our perception may change in an instant depending on how much and what exactly we know. But two Danish photographers have taken the idea to a whole new level.
More than 60,000 Americans have died in just 60 days. All 10 years of the Vietnam War compressed into 2 months. This is just......horrible and heartbreaking beyond words.
Those fools played themselves(Picture)
The Military Was Just Ordered To Active Duty -- STATESIDE?!
By: femalefaust
PROTESTS/REVOLUTION
The executive order (fulltext hyperlinked), is dated April 1, 2020 but was revised on the 30th. The same day the lockdown orders — extended on March 29, effectively lapse.
Never Again!
There are several events in modern U.S. history that must never be allowed to happen again. Never, as in EVER!
I'm talking about false flag events that warmongering politicians have used to authorize U.S. military aggression and unjust war around the world and gross miscarriages of justice in violent despotic assaults against American citizens inside the United States.
I'm talking about the fabricated Gulf of Tonkin incidents in 1964 that launched an illegal and indefensible war in Vietnam. I'm talking about the premeditated and unprovoked attack on the USS Liberty by the State of Israel in 1967.
Tucker Carlson rips American feminists over silence on Biden allegations: 'There is nothing more corrupt'
Humboldt County Sheriff William Honsal announced his "firm opposition" to Governor
'Survival': Tenants, landlords brace for largest rent strike in decades | "If banks are getting bailed out and corporations are getting bailed out, why aren't poor people getting bailed out?" one activist asked.
Kenia Alcocer is used to sitting down at the kitchen table to crunch her family's monthly budget and figure out how she can make ends meet.
Pixfuture
New Study Reveals That 81% of the World Population Is Calling Upon Billionaires to Contribute More to Charity – Especially During COVID-19 Pandemic
In results released today by research agency Glocalities and international advocacy organization Global Citizen, a global survey reveals that 81% of the world population is calling upon billionaires to contribute and help close the financing gap for the Sustainable Development Goals (SDGs) – including healthcare for all. Conducted earlier this year in 25 countries among 26,786 people, the survey results are more urgent than ever now that the world is in the midst of the COVID-19 pandemic.
A Group Tried To Claim Ownership Of The Bisexual Pride Flag And The Community Backlash Was Swift
The bisexual flag has become a familiar sight at LGBTQ pride events with its stripes of pink, purple, and blue.
While it's now widely used, one group attempted to claim legal ownership of it on Twitter, causing all bisexual hell to break loose.
Indiana mail carrier fatally shot over stimulus check, union says; suspect arrested
By: pooja
An official with the Indianapolis branch of the letter carriers' union says the union believes the fatal shooting of a local mail carrier may have happened due to problems with the residents in a house on her route.
WH Econ adviser Kevin Hassett to reporters this morning: "The unemployment rate is probably up around 19%. And those numbers are as startling as anything we've seen since the Great Depression."
Mayor of Cali Colombia forcing people out of their homes because they have a cough, reported by a neighbor, they are HUNTING people now literally
As Trump Claims US Has Best Covid-19 Testing in the World, Capitol Physician Says He Lacks Capacity to Test All 100 Senators
Shad Sullivan - We Are Being Forced To Dump Your Food Supply
Biden Accuser Tara Reade Willing To Testify Under Oath About Sexual Assault Allegation
After a week of media speculation, as more and more evidence comes forward lending credibility to claims, Tara Reade has publicly stated her willingness to testify under oath regarding her sexual assault allegation against former Vice President Joe Biden.
Biden Sent Operatives To University To Go Through His Records, Refuses To Release Them
Democrat presidential candidate Joe Biden has reportedly sent campaign operatives to the University of Delaware to go through his Senate records after he was accused by former staffer Tara Reade of sexual assault.
Epstein Victim Maria Farmer Calls Billionaire Les Wexner 'The Head of The Snake' in Bombshell Interview
Jeffrey Epstein victim Maria Farmer, who along with her younger sister were the first to report Epstein to the FBI all the way back in 1996, made a series of shocking allegations in a lengthy interview with journalist Whitney Webb.
Farmer accused the FBI of covering for Epstein and being "in on it" and said she thinks pro-Israel billionaire Les Wexner is the "head of the snake" when it comes to the Epstein network's operation in America.
Defiant city officials hold emergency meeting to consider suing Gov. Newsom over his order to close beaches
The battle over California's beaches ramped up on Thursday when Huntington City officials sought to consider the option of suing Democratic Gov. Gavin Newsom over the order in response to the coronavirus threat.
Joe Biden On Tara Reade Sexual Assault Allegations: 'They Aren't True. This Never Happened'
Joe Biden, the presumptive Democratic nominee for the November presidential elections, Friday denied the sexual assault allegation raised against him a former senate aide, saying the incident "never happened."
In a statement released ahead of an interview on MSNBC's "Morning Joe," where addressed the issue after a long silence, Biden said about the allegations raised by Tara Reade on March 25: "They aren't true. This never happened."
April 14 Executive Order reveals impending disaster may be coming to the U.S.
FREE SH*T ARMY! Stimulus Proposal: $2,000 Payment Plus $1,000 Per Month Until 1 Year After Crisis Ends
Executive order from @POTUS ordering selective US military reserve units to active duty
BREAKING NEWS: 'This never happened. I don't know why she's saying it': Joe Biden denies sexual assault allegation by former Senate staffer and asks National Archives to open his personnel files - but WON'T open his personal archive
Five major U.S. airlines to require all passengers to wear masks
Five of America's largest airlines announced this week that they will require all passengers to wear masks during travel, as pressure mounts from unions and Senate Democrats for the federal government to issue a mandate requiring that facial coverings be worn by everyone on any U.S. flight.
Israeli Helicopters Carry Out Attacks in Southern Syria - Syrian Media
The attack comes just days after Syrian media reported what it described as "Israeli aggression from Lebanese airspace", in which at least three civilians were killed.
Israeli helicopters have fired several missiles from the occupied Golan Heights on targets in southern Syria, SANA news agency reported on Friday. According to SANA, the attack made "limited material damage" only, with no casualties.
Cuban Biotech to the Rescue: The Story of a Potential Anti-COVID-19 Drug Told By One of Its Creators
The Cuban biotech industry has offered its own tool to fight the coronavirus disease. Dr. Manuel Limonta, one of the founding fathers of Cuba's biotechnology initiative, has explained how the island nation has mastered itself in producing interferon, a drug chosen by a number of countries to treat COVID-19.
Amid the media buzz about hydroxychloroquine, an anti-malaria drug lauded by Donald Trump as a potential cure against COVID-19, recombinant interferon remains neglected despite being one of medicines which have proven effective in curbing China's coronavirus epidemic.
Space Spinoffs: The Technology To Reach The Moon Was Put To Use Back On Earth
The Apollo program was gigantic.
The U.S. government spent roughly $26 billion (about $260 billion in today's dollars, according to one estimate) between 1960 and 1972 to hire contractors and subcontractors who employed hundreds of thousands of people to create and improve on technology that led us to the moon and back.
While some of that tech has stayed within the space industry, a lot of it has trickled down to the public. There's a huge list of the stuff. NASA has an entire department dedicated to cataloging it all.
Pakistan Hires Thousands of Newly-Unemployed Laborers for Ambitious 10 Billion Tree-Planting Initiative
Although the novel coronavirus pandemic has driven thousands of workers into unemployment, the Pakistani government has found a way to provide jobs to their citizens while also reforesting the nation.
Seven inventions from the Apollo space program we still use today
It's been nearly 50 years since NASA put a man on the moon but many of the technologies invented for the groundbreaking Apollo space program are still used in our lives on Earth today.
From the tiny cameras in our cellphones to the heat-proof uniforms used by firefighters to protect them from the dangers of the job — here are seven famous inventions from the 1960s moon shot.
Xiaomi Devices Found Tracking And Recording Browsing Data Of Millions
Xiaomi has been tracking and recording an insane amount of private data, from user's phone habits to queries in the Xiaomi's default browsers.
Coronavirus News: 100 bodies found in unrefrigerated trailers outside Brooklyn funeral home: Police source
Elon Musk Doubles Down With A Vengeance: Lockdown Policies 'Fascist'
Speaking on a Tesla earnings call on Wednesday, founder Elon Musk ramped up his rhetoric about shelter-in-place orders around the nation, calling them "fascist." Stock in Tesla jumped on Thursday, initially rising as much as 8.7%, then settling in at a rise of 4.6% later in the day, possibly due to Tesla announcing better-than-expected adjusted earnings per share for the first quarter.
California Gov. Gavin Newsom is set to announce the closure of all beaches and state parks
Nancy Pelosi Appoints Only Democrats To House Select Coronavirus Committee
Speaker of the House Nancy Pelosi has appointed seven Members of Congress to her House Select Coronavirus Committee, designed to "oversee" how the White House spends the money allocated for coronavirus relief in the CARES Act, passed last month — and perhaps to no one's surprise, the committee has only Democrats.
Coronavirus: "I got you gal!"(Cartoon)
Israeli Historian Discovers '6 Million' Holocaust Figure Was Invented at Zionist Conference In 1944
Boston University's director of the Elie Wiesel archive, Bar-Ilan University's Institute of Holocaust Research historian Joel Rappel has discovered the origin of the infamous "6,000,000" number: a 1944 meeting of Zionist pioneering organizations in what is now known as the state of Israel.
For years, supporters of the Holocaust narrative have held that the number first appeared at the Nuremberg trials using highly discredited testimony by Auschwitz commandant Rudolf Hoss. The 6,000,000 figure was again repeated by Adolf Eichmann, who was kidnapped by the Mossad and forced to participate in an internationally televised 1962 show trial in Israel.
According to documents in the Central Zionist Archive, the first mention of the 6 million claim was at a meeting of high ranking Zionist political figures in Palestine on January 19th, 1944 — more than a year before the war in Europe ended and a census could be taken, and a year before the Red Army entered Auschwitz.
University Won't Release 1,850 Boxes of Biden Records That Could Confirm Tara Reade's Story
The University of Delaware, home to almost 2,000 boxes of records from Joe Biden's career in the Senate, was already three months late in making those documents available to the public and was pushing their release back to the end of 2019 at the earliest.
Is Q1 GDP Data Masking The True Global Economic Future?
There's good food out there and nothing should go to waste, we can do better(12 Pics)
Biden faced zero questions on sexual assault allegations in 19 interviews — and now the media has asked Trump
President Donald Trump took a question about the sexual assault allegations against Joe Biden on Thursday and social media did not let the double standard go unnoticed.
LGBT-owned restaurant uses drag queens to bring food orders to cars during coronavirus: 'It's just a way we can expose ourselves to them'
Many restaurants have found a way to stay afloat amid the coronavirus that's shuttered most businesses by offering delivery and to-go service — and at least one eatery is adding a bit of flair to the deal.
Madonna, 61, posts bizarre video saying she's 'going for a drive to breathe in COVID-19 air' because she already has coronavirus antibodies after getting tested
Madonna has revealed that she already has coronavirus antibodies after getting herself tested for the virus.
The 61-year-old pop legend made the revelation in an Instagram video on Thursday, which is part of a series she's dubbed her "Quarantine Diaries."
Michael Moore's latest film targeted 'renewables' & accused 'green' groups of being in Big Energy's pockets. It hit a nerve
The Climate Industrial Complex is calling for filmmaker Michael Moore's head after his latest film skewered the hypocrisy of the "renewable energy" industry, exposing its leaders' cozy relationship with the fossil fuel bogeymen.
Moore's climate change polemic 'Planet of the Humans,' directed by Jeff Gibbs, has been viewed over four million times on YouTube in just over a week. But just two days after the film's release, timed for Earth Day, filmmaker Josh Fox led the charge to have Moore – once a "hero" of his – deplatformed over alleged disinformation. In an earnest letter, Fox demanded not only a "retraction and an apology" from Moore but for the film to be yanked from distribution entirely.
Bill Gates paralyzed half a million children with polio vaccines – do we really want him vaccinating the world for coronavirus?
It is difficult to understand how a man whose vaccine initiatives have injured and killed untold thousands of innocent children all around the world is now being given a platform to push for mandatory Wuhan coronavirus (COVID-19) vaccination as a condition for ending the lockdowns.
Bill Gates, in case you had not yet figured out the character in question, is pushing not just for mandatory vaccination for the Wuhan coronavirus (COVID-19), but also for "digital certificates" that prove vaccination status. This is the only way people will be allowed to return to work, assuming Gates gets his way.
US Navy detonates unexploded WWII-era ordnance off Hawaii
U.S. Navy explosive ordnance disposal technicians have detonated two World War II-era bombs and removed other ordnance in waters off a Hawaiian island.
The Navy carried out the controlled explosions Monday in a well-traveled channel between Lanikai Beach and Mokulua North on Oahu, an area also known as Mokunui Islet, The Honolulu Star-Advertiser reported.
A snorkeler reportedly discovered the munitions and contacted the U.S. Coast Guard, which alerted the Navy.
US State Dept. Says Russia and China Have No Reason to Vote Against Prolonging Iran Arms Embargo
RUSSIA/BELARUS/UKRAINE
Russia and China have no reason to vote against the prolongation of the arms embargo on Iran, US Special Representative for Iran, and Senior Advisor to the Secretary of State Brian Hook said.
"Russia and China have great equities in a peaceful and stable the Middle East, and Iran's sectarian violence and its export of weapons is the principal driver of instability in the Middle East today. And because they voted on it in the past, there's no reason why it can't be voted on again", Hook told reporters on late Thursday.
Michigan Gov. Whitmer extends coronavirus state of emergency another month despite armed protesters storming the capitol as lawmakers donned bullet-proof vests to vote on bill allowing them to sue her (37 Pics)
'Immunity' with benefits? Germans worried as govt mulls IDs 'making life easier' for Covid-19 survivors
Berlin is reportedly considering issuing IDs confirming the bearer is immune to Covid-19 and may have more freedom than the as-yet uninfected. It adds to debate on whether recovery from the virus protects humans from reinfection.
Germany's federal government has passed a bill that would allow for handing out "coronavirus immunity cards" to anyone who has recovered from – and thus developed enough antibodies against – the disease, according to Suddeutsche Zeitung newspaper, citing a copy of the document.
Ryanair vows to refund 25million customers in six months: Michael O'Leary insists he will take 50% paycut from £3m salary as he slashes 3,000 jobs - while Heathrow sees 97% drop in passengers in last month
By: suman
Ryanair boss Michael O'Leary has today cut up to 3,000 jobs but vowed to refund 25 million out-of-pocket customers - as Heathrow sees a 97 per cent drop in travellers in the last month.
The airline said a stringent restructuring programme will begin in July, with some 3,000 pilot and cabin jobs under threat.
Did America just have its permanent retail apocalypse.
South Dakota Considers First State Bill To Outlaw All Vaccine AND Medical Mandates
Who owns your body?
A growing number of legislators in South Dakota believe you do.
They have introduced a bill to not only end vaccine mandates in the state, but all future medical mandates that my be introduced in generations to come.
One hundred and fifteen years ago this month, the US Supreme Court made a decision that because there was a deadly smallpox epidemic, the City of Cambridge, Massachusetts was allowed to charge a pastor five dollars to opt out of a city wide vaccine mandate. The law didn't apply to children.
That precedent has been the basis for the mandate of dozens of now liability-free vaccines for children and adults, where no epidemic (or even one case) exists, at the costs of thousands, or even hundred of thousands, per year to opt out. It is even the basis on which the Supreme Court ruled that women can be force sterilized, for the good of themselves and society, of course.
A republican we would have voted for(Picture)
Thanks to COVID-19, now you can get married online in New York City
New York City is letting its residents get married online amid the COVID-19 outbreak.
Climate expert calls for Michael Moore's 'shockingly misleading' new doc to be taken down
Planet of the Humans, the brand new Michael Moore-produced climate change documentary, has become the subject of widespread controversy after being accused of being "riddled with falsehoods and misinformation" by a leading climate change activist calling to have the film removed.
Webmaster's Commentary:
Business owner arrested for reopening tattoo shop amidst North Carolina's stay-at-home order
A North Carolina business owner was arrested for violating the state's stay-at-home order. Matthew "Jax" Myers opened his tattoo parlor on Wednesday, and within minutes he was arrested.
Dow jones: Watching the celebrating wounded bulls getting excited is of concern ...Text book counter rally nearing its culminating high.
Nancy Pelosi tried to Sneak "Universal Income" into COVID bill "a minimum guaranteed income,"
WTF! Teens temporarily no longer required to take road test to get driver's license in Georgia
Russia Warns of 'Consequences' Over Czech Poison Plot Allegations
Russia's foreign ministry on Wednesday threatened "serious consequences" after a news report in the Czech Republic alleged that a Russian agent had been dispatched to poison officials in Prague.
The report in the newspaper Respekt, citing unnamed Czech intelligence sources, alleged a Russian intelligence agency plot in apparent retaliation for Czech decisions to honor a slain Russian opposition leader and to remove a Soviet-era statue.
Russian PM Tests Positive for COVID-19 as Putin Warns Peak Has Yet to Come
As the number of confirmed coronavirus cases reported in Russia passed 100,000, Prime Minister Mikhail Mishustin announced Thursday that he has tested positive and is temporarily stepping back from his work to recover.
Mishustin informed President Vladimir Putin of his diagnosis during a video conference. Putin wished Mishustin a swift recovery and signed a decree appointing First Deputy Prime Minister Andrei Belousov as acting prime minister.
She paid $15,000 for mom's final arrangements — and now worries Brooklyn funeral home stored remains on unrefrigerated U-Haul truck
A Brooklyn woman says that weeks ago she paid a funeral home $15,000 to handle her mother's final arrangements — and now wonders if she was one of the rotting corpses police found in unrefrigerated U-Haul trucks.
KENNEDY: We Have Allowed Ourselves To Become Bill Gates' Guinea Pigs
Other Billionaires (Trump, Bloomberg) run for president. Gates' strategy of buying #WHO & purchasing control of US health officials like Tony #Fauci & #DeborahBirx has yielded him powers exceeding, in some respects, those wielded by presidents.
Control of WHO allows #BillGates to dictate global health policies affecting 7 billion people and to control the most intimate details of our lives; when and where we work, play sports, shop, attend school, go to beaches, bars, movies, concerts and what medicines we must and must not take. His minions may compel us to wear masks, lock us in our homes and ordain how close we can stand to our loved ones. #Gates is WHO's second biggest donor after the USA.
About One-Fifth Of All The Jobs In The U.S. Are Already Gone, And This Economic Depression Is Just 6 Weeks Old
Paid Placement. The above headlines represent the views of NewsMax and may not be the views of WRH.


text:
Aug 07, 2017 · 01:32 pm Updated Aug 07, 2017 · 04:41 pm
After Friday's two-year high, Indian rupee weakens to 63.73 against US dollar
The greenback pulled ahead because of strong jobs growth data in July.
The Indian rupee weakened 17 paise to 63.73 against the US dollar on Monday after banks and exporters sold American currency. The dollar pulled ahead following reports of strong job growth in July, forex dealers said, according to PTI. The rupee had ended at a fresh two-year high of 63.58 on Friday.
The executive chairman of Templeton Emerging Markets Group at Franklin Templeton Investments, Mark Mobius, told Mint that he expects the rupee to appreciate to around Rs 60 a dollar by the end of 2017 on the back of growth in India and rising reserves.
Angel Commodities said that the rupee is expected to strengthen towards 63.20 in August because of the Reserve Bank of India's decision to cut its lending rates, according to The Economic Times. "Also, uncertain global political scenario shall prompt foreign investors to flee towards emerging markets, including India, benefitting the rupee," Angel Commodities said.
Sensex, Nifty suffer marginal losses
Meanwhile, India's benchmark indices were fluctuating between positive and negative territory. The Bombay Stock Exchange Sensex closed 51.74 points below at 32,273.67 while the National Stock Exchange Nifty ended nine points lower at 10,057.40.
Stocks of Tata Steel (4.26%), the State Bank of India (1.85%), Adani Ports (1.59%), and ICICI Bank (1.28%) gained on both indices, while those of Infosys, TCS, Tata Motors and NTPC performed poorly.
Among the sectoral indices, metal – led mostly by gains in Tata Steel – performed well, followed by oil and gas and realty. Inormation Technology was the worst performer.
Why is Coca-Cola so eager to buy Cafe Coffee Day?

redpajama_set_name: RedPajamaCommonCrawl


Tri-Bridges are 3-way bridges on which traffic crosses two water streams or a body of water/lake from 3 directions and one can travel from any direction to any direction. There are not many such bridges in the World. In 2009 I started searching for such bridges around the World and could find only a dozen such bridges which were included in the post - Tri-bridges Around the World.
Recently one of my reader (vldecker) sent me a link about another such bridge in Louisa, KY, USA.
The Louisa Louisa/Fort Gay Tri-Bridge at the confluence of Levisa and Tug Rivers is a T-shaped bridge. Opened in 1906, it is reportedly the only bridge in the U.S.A which not only spans two rivers but also connects two states (Kentucky and West Virginia), two counties (Lawrence County, Kentucky and Wayne County, West Virginia), and two cities (Louisa, Kentucky, and Fort Gay, West Virginia).
Credits: I am grateful to reader vldecker whose comments on my post brought this to my knowledge. I had missed this more than a century old bridge in my collection. Thank you vldecker.


Condition: New First Year SpectraCare+, Spectralink 80/84 - Series. MUST BE PURCHASED AT TIME OF SALE. (SMS84105) Overview First Year SpectraCare+, Spectralink 80/84 - Series. MUST BE PURCHASED AT TIME OF SALE.
Condition: New First Year SpectraCare, Spectralink 80/84 - Series. MUST BE PURCHASED AT TIME OF SALE. (SMS84100) Overview First Year SpectraCare, Spectralink 80/84 - Series. MUST BE PURCHASED AT TIME OF SALE.


Paricipants in Bertelsmann University's "HR in M&A" programEnhancing a company's growth through corporate mergers and acquisitions (M&A) with the expertise of colleagues from the HR departments: That is the central idea of a new international training program introduced by Bertelsmann University. The "HR in M&A" program recently ended with the conclusion of the fourth and final training module in Baden-Baden. Employees from Arvato Solution Groups Financial Solutions, SCM Solutions and Digital Marketing from Germany, the Netherlands, Ireland and the U.S. had participated in the program that stretched over the course of a year.
The idea behind it was to give HR colleagues integrative, comprehensive training on the topic of mergers & acquisitions so that they can provide professional support in the "inorganic" growth process. Participants were taught not only about the basics of M&A, but were also familiarized with the latest research and developments in the field, as well as being provided with tools that they themselves could implement during different stages of a merger.
The "HR in M&A" training consisted of four two-day modules. Experts from London and Vienna were responsible for the training content, which was developed specifically for Bertelsmann under the lead management of Bertelsmann University. However, what made this program especially unique was that beyond the theoretical knowledge, practical field reports from the Bertelsmann M&A world were an integral part of the program's curriculum. In "fireside talks", experienced Bertelsmann colleagues including; Ralf Süllwald (Senior Vice President Corporate Legal in Corporate Center), Jörn Caumanns (Head of M&A in Corporate Center), Steven Moran (Chief Learning Officer at Bertelsmann), Frank Steinert (Chief Human Resources Officer at Penguin Random House in New York), Elias Reitter (Chief Financial Officer Arvato Financial Solutions) and Martina Mönninghoff (Vice President of Bertelsmann University) shared their experiences in dealing with M&A projects in the Bertelsmann world, and also spoke to participants about their first hand involvement.


Just watch the JWs cry out "Persecution from Satan!"
If you hear someone say that, just repeat this expression: "Prosecution IS NOT Persecution"
Fake News is the new response. It's not persecution cuz it didn't happen.
This is huge news for the Netherlands.
So far 276 potential cases of abuse been reported.
Maybe police ,law enforcement`s and child protection authorities , are seeing for the first time how widespread this child sexual abuse is going on in Jehovah`s Witness communities around the world and are finally going to do something about it ?
This is great news! Now we need the FBI to raid New York headquarters.


text:
The Grants-Milan Flight Service Station, at 1116 N. Dale Carnutte Rd. in Grants, New Mexico, was added to the National Register of Historic Places in 2015.

It was then part of the Western New Mexico Aviation Heritage Museum, which honors early aviation pioneers who flew the Los Angeles-to-Amarillo segment of the Midcontinental Airway.

It is a flight service station that was built in 1953 to serve the Grants-Milan Municipal Airport.

Western New Mexico Aviation Heritage Museum
The Western New Mexico Aviation Heritage Museum is a small aviation museum located at the Grants-Milan airport (KGNT) in Grants, New Mexico.  It was dedicated on June 9, 2012.

It commemorates the Los Angeles to Amarillo segment of the Transcontinental Air Transport, an early air mail provider.  It consists of two 1929 structures: a 55-foot beacon tower and a small building with a generator. It also has a concrete arrow which helped aviators find the correct direction to continue in.

References

External links

official site

Museums in Cibola County, New Mexico
Aerospace museums in New Mexico
National Register of Historic Places in Cibola County, New Mexico
Transportation buildings and structures on the National Register of Historic Places in New Mexico
Commercial buildings in New Mexico
Commercial buildings completed in 1953
History museums in New Mexico

redpajama_set_name: RedPajamaWikipedia


The main modes of travel are taxis (�official� and �unofficial�), ojeks (motor cycle taxis which you can hire to take you to your destination as a pillion..
Batam nightlife�s scene features bars, nightlifes, karaokes and discotheques. Nightclubs are mainly to be found in the bigger quality hotels usually with..
Situated at Nongsa, Batam's unspoiled north coast, Batam View Beach Resort was the first built on Batam. With 10 hectares of landscaped gardens, private beach and natural beauty, Batam View Beach Resort remain Batam's largest resort property.
From Batam View Beach Resort commanding position, the property offers sweeping views of Batam, the skyline of Singapore and the South China Sea. From Singapore, it is 35-minute ferry ride away.Meanwhile a Golf Course is merely 3 km away.
Air Conditioning, Television, Balcony/Terrace, Coffee/Tea Maker, Desk, Internet Access(complimentary), Mini Bar, Refrigerator, DVD/CD Player, Internet Access, Internet Access(wireless), Satellite/Cable TV, Shower, IDD Telephone, Hot & Cold Water, Toiletary.
Number of rooms: 179 Use of the Lounge. Amenities: Remote control 20' Color TV, Mini Bar and Fridge, Satellite & Cable TV, IDD Service, Showers, Master Bedside Control Panel for Radio and Lighting, Soap/Shampoo/Bathfoam/Body Lotion, Room Service, Private Balcony.
Adjoining living room and wet bar. Number of rooms : 16. Amenities: All Standard Amenities plus, Orchid Arrangement, Welcome Fruit Basket and Wine/Champagne on request.
For those who appreciate an environment of privacy and extra privilege, the exclusive Villa Wing is designed to further enhance ones stay. Batam View Beach Resort guests can be assured of a high degree of warm, friendly service in a locally designed wooden villa, complete with a kitchenette and all modern amenities.
The 5th Dimension Spa, Kelong Sundanese and Thai Seafood Restaurant, Wangi Melati Coffe House, Restaurant, Islander's Lounge, Poolside Bar, E-Scape Discotheque, Indoor/Outdoor Recreation facilities, Function Rooms and Convention Hall.
Turi Beach Resort is located in Nongsa Resort area, on the north east coast of Batam. Turi Beach Resort..
The Panorama Regency Hotel is a luxury hotel, located in the center of Nagoya - Batam. Panorama Regency..
The Planet Holiday Hotel & Residence excellently located within the Central Business district between..
Novotel Batam is located in Batam Island, Riau archipelago, Indonesia. Novotel Batam is in the heart..
Goodway Hotel (formerly known as Mandarin Regency) is located in the heart of downtown Nagoya (Now widely..
Puri Garden Hotel located in right in the heart of Nagoya (Now widely knows as Lubuk Baja). Puri Garden..
• Batam View Beach Resort.. • Goodway Hotel (Mandarin Regency).. • Harmoni Hotel.. • Harris Resort Batam..
• Holiday Inn Resort Batam.. • Mercure Batam formerly Royal Hotel Batam.. • Novotel Batam.. • Panorama Regency Hotel..
• Planet Holiday Hotel.. • Swiss Belhotel Batam.. • The Hills Batam formerly Puri Garden.. • Turi Beach Resort..


Phyllo appetizer bites are easy to make and a tasty appetizer to have on hand for guests. You'll love the flavor of this cheese and cherry combination.
If you like these appetizers, you'll love our Pesto Cheese Blossom, Spicy Artichoke Dip, and Copycat Bloomin Onion.
Need a super easy appetizer for your next holiday gathering? If so, you'll definitely want to give these bite-sized phyllo cups a try.
You'll want to bake these cute appetizers up in a mini muffin pan if you're working with phyllo sheets instead of phyllo cups.
The flavors of warm, melted Brie and sweet dark cherries are enhanced with a slight hint of maple syrup. For a more complex and savory flavor combination, add some fresh thyme leaves to each cup prior to baking.
You'll love this fun and fruity appetizer. Cherry is a delicious filling for these appetizers, but you could also mix things up and try jam, fig, and berry fillings.
One of the best things about this appetizer recipe–besides the taste–is how easy it is to make. We're talking about a recipe that is so easy to whip up that you'll wonder why you haven't made them before.
It's also one of those recipes that will get your creative juices flowing. As in–think of all the vast fillings that you can put in these flaky phyllo cups.
Personally, we can think of about a dozen twists for this delicious appetizer recipe!
If you enjoy these Brie and Cherry Phyllo Cup appetizers, you'll probably love making other kinds of appetizers with phyllo cups.


text:
require 'rubygems'
require 'json'
require 'yaml'

require 'json_csv_converter/version'
require 'json_csv_converter/csv'
require 'json_csv_converter/converter'

module JSONCSVConverter

  def json_to_csv json,csv,mapping,options={}
    Converter.new(json,csv,mapping,options).json_to_csv.csv_table
  end

end

redpajama_set_name: RedPajamaGithub


Reviews for Ashwoods Contracting Ltd.
We were looking for a carpenter to install some crown moulding and went to Turkstra Lumber to ask if they could recommend someone. They gave us two names and we called Melvin from Ashwoods Contracting. He gave us an estimate and we accepted. He showed up when promised, did an amazing job, since our house has some weird angles. We then had a problem with our deck and hired him again. One more time, he didn't disappoint. The problems have disappeared and we will definitely hire Melvin again.
Excellent job. Pricing not the cheapest but very competitive. The workmanship was second to none. Arrived when they said they would and completed the job finished to my complete satisfaction. Melvin is a very talented man. Also installed a new kitchen counter top and did a great job on it also.
Ashwoods Contracting Ltd. has not added any photos.
Looking for Fences & Gates pros in Smithville?


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Addoku/Killer Sudoku is a Sudoku and Kakuro crossbreed that's twice the fun!
Try Lovatts online version and when you're finished, click over to YouPlay.com for an even greater variety of fun and free Lovatts online puzzles and games – updated daily!
Use the mouse to click up (or down) through the numbers 1-9 in each square. The small black arrows in the left and right of the square tell you whether you're counting up (right) or down (left) through the numerals.
When you've completed each set correctly, that set of numbers will be shaded in – there's a different colour for sets of one, two, three, four etc. numbers.
Click in the bottom of each square below the dotted line then use the keyboard to type in possible numbers in a square.
The Killer Sudoku / Addoku is like a traditional Sudoku in that every row, column and 3×3 block must contain the numerals 1-9. The difference is that you are not given numbers to start you off. The numbers that occur in the squares linked by a shaded line add up to the total given in the top left-hand corner of each set. No number is repeated in any of these sets. Use these totals to find the right numbers to solve the puzzle.
In the Killer Sudoku the rows and columns do not get shaded in as you complete them correctly. But when you've completed each set correctly, the set of numbers will be shaded in – there's a different colour for sets of one, two, three, four etc.
Use the mouse to click up (or down) through the numbers 1-9 in each square. The small black arrows in the top-right or bottom-left of the square tell you whether you're counting up (top-right) or down (bottom left) through the numerals.
Single digits can be filled in straight away. Then look for two-digit sets and work out the possible combinations. For example, the total 3 can only be 1 & 2. 17 can only be 9 & 8 but 8 could be 1 & 7, 2 & 6 or 3 & 5; so it can't be 4 & 4 because each row, column, block and set can contain only one of each number.
You can type these possible numbers at the bottom of each square. Then do the same with three and four digit sets. Eventually patterns will emerge as you eliminate possibilities.
It is also useful to remember that the numbers in each row, column and 3×3 block add up to 45. If the shaded sets fill a row, column or block with just one number protruding into another row, column or block, then that number will be the total of the shaded squares minus 45.
Always remember you basic Sudoku rules that no numeral 1-9 can be repeated in any row, column, 3×3 block or set of numbers – you'll soon unravel the Killer Sudoku!
The symbol shows the level of difficulty – the more symbols, the harder the KIller Sudoku.
When you have correctly completed all of the numbers in a set so that the numbers linked by the shaded line add up to the total given in the top left-hand corner, the squares will be shaded in – there's a different colour for sets of one, two, three, four etc. numbers.
The timer starts as soon as you open the Killer Sudoku. If you don't like working against time just click on Hide Timer at the top of the Addoku puzzle. Your time will be displayed when you finish the Addoku.


Suat Karantay is a Professor of Translation Studies at Boõaziçi University in Istanbul. He is the Secretary General of the Turkish PEN Center, and the author of numerous articles on translation theory and criticism, as well as on drama and American literature, and many translations of Turkish poetry. He is the editor of Short Dramas from Contemporary Turkish Literature, and directs the Contemporary Turkish Literature website.


text:
Brattfors socken i Värmland ingick i Färnebo härad, ingår sedan 1971 i Filipstads kommun och motsvarar från 2016 Brattfors distrikt.

Socknens areal är 219,00 kvadratkilometer varav 199,05 land. År 2000 fanns här 524 invånare. Det tidigare järnbruket och kyrkbyn Brattforshyttan med sockenkyrkan Brattfors kyrka ligger i socknen.

Administrativ historik
Socknen bildades 1661 genom en utbrytning ur Nyeds socken för att fram till 1770 vara en kapellförsamling till Färnebo församling.

Vid kommunreformen 1862 övergick socknens ansvar för de kyrkliga frågorna till Brattfors församling och för de borgerliga frågorna bildades Brattfors landskommun. Landskommunen uppgick 1952 i Värmlandsbergs landskommun som 1971 uppgick i Filipstads kommun. Församlingen uppgick 2010 i Filipstads församling.

1 januari 2016 inrättades distriktet Brattfors, med samma omfattning som församlingen hade 1999/2000.

Socknen har tillhört län, fögderier, tingslag och domsagor enligt vad som beskrivs i artikeln Färnebo härad.

Geografi
Brattfors socken ligger väster om Filipstad kring Svartån och Lungälven samt sjöarna Lungen och Alstern. Socknen är en kuperad moss- och sjörik skogsbygd.

Fornlämningar
Boplatser från stenåldern har påträffats. Från bronsåldern finns gravrösen.

Namnet
Namnet skrevs 1540 Brattefors hytte och avsåg då hyttan som socknen fått sitt namn av. Förleden bratt, 'brant' syftar på en brant fors i Lungälven.

Se även
 Brattfors församling

Referenser

Vidare läsning
Sveriges bebyggelse: statistisk-topografisk beskrivning över Sveriges städer och landsbygd. Landsbygden. Värmlands län, del 1 Hermes 1962 libris

Externa länkar

Indelningar i Filipstads kommun
Socknar i Färnebo härad


Overall, I think the new paperback (below) is stronger. Gone are the "octopus legs" from the hardcover and the rather unfortunate placement of the words "A Novel."
But what struck me when I first saw the new paperback was how wonderful the shape of the negative space is, and how it's obscured by all the frilly detail. I didn't replace the title and author text, but would this be stronger without so much detail?
The very top one is certainly the better of the three. Another catchy cover. Good effort.
It is a stunning cover in all it's incarnations.


text:
Q: Excel 2010 document contents not scrolling with scrollbar For some reason on a couple of computers, Excel 2010 is having issue with the scrollbar.
When the vertical scrollbar is dragged, the contents of the page do not follow (for example, as they do in a browser). When the scrollbar is released, Excel will jump to that position. The mouse scroll works fine.
This is annoying as it makes it difficult to quickly scroll through long spreadsheets with a visual indicator of where you will 'land'. Other Excel 2010 installations exhibit this desire behaviour.
I have searched online and nearly everything refers to frozen panes, but there are none in these spreadsheets, and the scrollbar functions as intended when viewed on another computer.
Any suggestions?
Edit: It seems to be all of Office experiencing the issue. Repair does not help. Reinstall does not help. Deleting registry keys does not seem to help. Issue only affects only single user of machine- logging on as a different user, the problem is not apparent.

A: What worked for me:
Excel > File tab > Options > Advanced > (Dispaly section) > Tick the "Disable harsware graphics acceleration"

A: I'm not sure about Excel in particular, but for most applications this is controlled by the Show window contents while dragging setting.
This is in a different location depending on the Windows version.
In Windows XP, right click on the desktop and click Properties. Click on the Effects... button. Second from the bottom is the Show window contents while dragging checkbox.
In Windows 7, open the Start Menu, search for Appearance, and choose Adjust the appearance and performance of Windows. Go to the Visual Effects tab. The Show window contents while dragging checkbox is about two-thirds of the way down the list in the Custom list box.

A: If I understood your problem correctly, the scroll bar moves but the columns don't. If that is correct - unfreeze the panes [View Tab- Click the little arrow under Freeze Panes - choose Unfreeze Panes]. Then you can refreeze them.
Source:
http://dfarq.homeip.net/2013/10/what-to-do-when-your-excel-worksheet-wont-scroll/

redpajama_set_name: RedPajamaStackExchange


Melanie Morgan has joined Costrini Sleep Services as the Practice Manager. Melanie is a successful business office manager with outstanding skills in revenue enhancement and collections optimization, financial management, and daily operations of physician practices. She is a Certified Physician Practice Manager and Certified Professional Biller. She has worked in Cardiology, Pulmonology, Neurology, Dermatology and Plastic Surgery. She leads with a very hands-on approach to daily operations and has developed proven strategies in the management of accounts receivable and billing, personnel, budgeting, marketing, contracting and strategic planning.
Our clinical staff includes licensed, experienced Nurse Practitioners, Respiratory Therapists, and Sleep Technologists. Our patient services staff consists of professionals dedicated to improving the quality of life of our patients. Our respiratory therapists are credentialed by the National Board for Respiratory Care and licensed by the states of Georgia and South Carolina.
Dr. Costrini has been actively involved in sleep disorders medicine since the late 70's, opening one of the first sleep disorders centers in southeast Georgia. In 2000, Dr. Costrini opened Costrini Sleep Services, a company dedicated to the diagnosis,treatment, and medical management of sleep disorders.
Dr. Costrini has given presentations at local, regional, and national scientific meetings on various sleep disorders topics. He has conducted research and authored or co-authored numerous scientific papers. These have been published in such prestigious journals as the American Review of Respiratory Disease, Journal of the American Medical Association, and the Journal of Sleep Medicine.
Dr. Anthony Costrini is board certified in pulmonary medicine, internal medicine, and critical care medicine. He is board certified in sleep medicine through both the American Academy of Sleep Medicine and the American Board of Internal Medicine. He is a fellow of the American College of Chest Physicians and the American College of Physicians, and a diplomate of the American Board of Sleep Disorders Medicine. He received his undergraduate degree in Biology from Loyola University in New Orleans, LA and his medical degree from Emory University in Atlanta, GA. He completed his fellowship in pulmonary medicine at Yale University School of Medicine. He also served two years in the military.
Jesse Childs is a Physician Assistant who is board certified with the NCCPA. She spent the first year of her career working in a primary care setting, and more recently decided to focus on sleep medicine.
She received her Master of Science in Physician Assistant Studies from South University in 2015.  Prior to that, she received her undergraduate degree from the University of Georgia in Nutrition Science.  As a former bodybuilder and nutritionist, she enjoys using her knowledge of physical wellbeing and proper diet to improve patient's health outcomes. Jesse is also passionate about helping patients improve their sleep quality with cognitive behavioral therapy.


text:
Epstein syndrome is a rare genetic disease characterized by a mutation in the MYH9 gene in nonmuscle myosin. This disease affects the patient's renal system and can result in kidney failure. Epstein Syndrome was first discovered in 1972 when two families had similar symptoms to Alport syndrome. Epstein syndrome and other Alport-like disorders were seen to be caused by mutations in the MYH9 (myosin heavy chain 9)  gene, however, Epstein syndrome differs as it was more specifically linked to a mutation on the R702 codon on the MYH9 gene. Diseases with mutations on the MYH9 gene also include May–Hegglin anomaly, Sebastian syndrome and Fechtner syndrome.

Signs and symptoms
Initial symptoms are often described as bleeding tendency and thrombocytopenia. Bleeding tendency may be observed in epistaxis and purpura. Other symptoms may include macrothrombocytopenia, proteinuria, nephropathy, sensorineural hearing loss, low platelet count, oral lesions and cataracts. The most common symptoms include macrothrombocytopenia, mild sensorineural hearing loss and nephritis. The symptoms and the severity of these symptoms vary between patients where most patients experience nephritis in childhood and then progress to kidney failure in adolescence.  In macrothrombocytopenia platelet sizes can reach to approximately 6.6 um compared to a normal platelet size of 2.5 um where 30% platelets can reach the size of an erythrocytes. This large platelet size can be compared with MYH9 disorders where platelet size can vary between 4.5 um and the 6.6 um that is found in Epstein Syndrome with mutations on the R207 codon.

Causes

Epstein Syndrome is caused by a mutation in MYH9 gene. This mutation is autosomal dominant and is thereby inherited if one or both parents carry the mutated gene. However, there have been cases where Epstein Syndrome has been sporadic or non-congenital. Mutations are found in the nonmuscle myosin heavy chain IIA and is associated with chromosome 22. The MYH9 gene encodes for tissues including platelets, cochlea, renal cells, neutrophils and eyes.

Pathophysiology

The main symptom in Epstein Syndrome is thrombocytopaenia. Thrombocytopaenia is generally inherited as an autosomal dominant gene and platelets are found to aggregate with either epinephrine or collagen. Platelets assist in blood clotting and coagulate when there are damages blood vessels. This coagulation attempts to cease bleeding. Thrombocytopaenia means there is low platelet volume in the blood. This means there are less platelets to coagulate in presence of a damaged blood vessel, which can result in bleeding problems. The platelets are large (macrothrombocytopenia) and often consist of neutrophil inclusions. The large size of platelets may be due to excess microtubule coils and tublin. This large size of the platelets also affects their ability to bind to each other to seal damaged blood vessels and stop bleeding.

Nephritis involves the inflammation of the kidney and this inflammation results in a reduced ability to filter blood and remove nitrogenous wastes. This excessive accumulation of wastes will result in a continued build-up of wastes including urea which interferes with metabolism.

One of the kidney's functions include osmoregulation which involves the regulation of osmotic pressure in the blood by regulating the water content in blood pressure. Through osmosis (water movement from a low solute concentration to an area of high solute concentration) water is reabsorbed back into the blood from nephron tubules in the kidney. This maintenance of water concentration in the blood is essential for maintaining blood pressure and is affected in nephritis.

Diagnosis
The cardinal symptom in Epstein syndrome is thrombocytopaenia with giant platelets (macrothrombocytopenia). A peripheral blood smear is taken from the patient and a light microscope is used to these identify giant platelets. Leukocyte inclusions are also examined for, because approximately 41.1% of R207 mutations have leukocyte inclusions. These are often abnormal neutrophils with a small size of approximately less than 0.7 um and have an abnormal

location on the non-muscle myosin heavy chain IIA (NMMHC-II). These inclusion bodies have RNA and no DNA. RNA in these inclusion bodies can be located in immunofluorescence analysis with the anti nonmuscle heavy chain IIA antibody.

Hematology analysers or a hemocytometer can be used to determine the amount of platelets. A sample of blood is drawn from a patient's arm. A small amount of platelets in blood smears compared to the normal range of 150,000 to 450,000 platelets in microliter of blood suggest thrombocytopaenia, which is a common symptom in Epstein syndrome.

A urine sample is often collected where a urinalysis can be used to determine the volume of proteins excreted in urine. Abnormal amounts of protein detected means the patient has proteinuria. Patients with Epstein syndrome often have large proteinuria where they excrete above 3.5g of protein in their urine in a day. This is one of the initial signs of renal disease.

Easy bruising and abnormal bleeding tendencies are also described in initial diagnosis. This supports the common misdiagnosis for chronic idiopathic thrombocytopaenia purpura in patients with Epstein syndrome. These symptoms are often noticed in early childhood due to the congenital cause of the disease.

Treatment
Epstein syndrome is regarded as a refractory disease. Treatments include renal transplantation, however, this may become problematic as patient's low platelet count (thrombocytopaenia) increase the risks of complications in surgery. Successful Renal transplants can arise from cadavers or from live donors. To minimize the risk of patient's losing too much blood during the perioperative period, HLA-matched platelet infusions can be used to maintain satisfactory platelet levels. Nephritis involves the inflammation of the kidney and this inflammation results in a reduced ability to filter blood. In order to ensure the transplanted kidney is recognised as 'self' by Major Histocompatibility cells, immunosuppression drugs are used post operation. Immunosuppression medication may include calcineurin inhibitor, antimetabolite and methylprednisolone and assist in suppressing the immune system's response to the transplanted kidney

Maintenance

As a result of nephritis, a healthy blood pressure becomes difficult to maintain and hence medication including vasopressin may be prescribed to maintain blood pressure. Severe nephritis may mean kidney dialysis is required to ensure the blood is being filtered. This may include either peritoneal dialysis or haemodialysis, however, haemodialysis is most common as Epstein syndrome patients will often eventually have renal transplants. Peritoneal dialysis involves blood being filtered through a membrane in the abdomen (peritoneum). Whereas haemodialysis involves blood being filtered through a dialyser, which consists of a semi-permeable membrane where toxins including urea are removed from the blood. Haemodialysis also filters blood quicker than peritoneal dialysis.

Intravenous immunoglobin treatments can be used to support the patient's immune system as well as medication with Prednisolone to reduce inflammation.

Sensorineural hearing loss is a common symptom in Epstein syndrome and can be treated with cochlea implants. Cochlea implants have four main parts including the electrode array, the transmitter, the receiver/stimulator and the microphone. The microphone is positioned behind the ear and receives sound waves, the processor then converts the sound into electrical signals. These electrical signals are further converted into electrical impulses in the cochlea where the transmitter is located, which in turn sends the signal to the auditory nerve. This results in a nervous impulse sent to the brain where the 'sound' is deciphered.

Prognosis
In most case Epstein syndrome patients will endure early-onset end-stage renal disease (ESRD) at the end of adolescence. Expected kidney failure means patients will need renal transplants in the near future.

Notable cases
In a study which investigated suitable management for severe Epstein syndrome, four patients were observed. Patient 1 demonstrated a common background and symptoms for Epstein syndrome. Patient 1 was a male who was initially diagnosed with chronic idiopathic thrombocytopaenia purpura in early childhood and then macrothrobocytopaenia. He progressed to kidney failure and began haemodialysis at seventeen years old. Patient 1 was only diagnosed with Epstein syndrome at the age of thirty-three where the mutation in the nonmuscle myosin was noticed. His eldest son also carried the same mutation.

An Epstein syndrome patient with oral lesions was recorded to be the first with this symptom. The patient was a twenty-six-year-old female who was diagnosed with thrombocytopaenia with purpura at age four. She was then finally diagnosed with Epstein syndrome at twenty-two years old when she developed symptoms for hearing loss as well as proteinuria and hematuria revealing poor kidney function. After an oral examination, palatal purpua in her mouth was observed.

A Japanese male was diagnosed with sporadic Epstein syndrome where both his parents did not have the R702H mutation. He was initially diagnosed with chronic macrothrombocytopaenia at three years old and throughout childhood symptoms for hearing loss and proteinuria were observed. At 24 years old his kidney failure had severely progressed as well as his hearing loss and thrombocytopenia. A genetic test confirmed he had the R702H mutation despite having no familial record of Epstein syndrome.

References

External links

Kidney diseases