Gavan is a Business graduate of UCD and holds an MSc in Computers from Queens University, Belfast. Prior to working as a Systems Engineer with telecoms giant Avaya, he founded 247meeting in 2005. A true entrepreneur, Gavan spotted a gap in the market for reliable and easy to use conference call. Over the last 13 years, Gavan has built the business in to a successful audio, video and web conferencing provider. Outside of a busy home life with 2 children, he once managed to attain a City and Guilds qualification in Sound Engineering (1820) and occasionally runs up and down a hill.
Stephen is an accomplished and enthusiastic Chartered Accountant, who through his extensive experience has distilled achieving the ambitious to a fine art. Stephen brings value to the business using his unique insight, not to mention his relentlessly sunny disposition and knack for putting anyone at ease with the most complex financial concepts. Stephen has worked in exotic locations like Riyadh, Sydney and his home town of Roscrea. Not sure of the meaning of downtime, outside of the office, Stephen is passionate about volunteering and getting his hands dirty in the community – he encourages you to do the same!
Ronan has been with 247meeting since the beginning and brings extensive telecommunications and IT experience having worked with Eircom, Imagine, Sage and Sitel for over 15 years. With a Diploma in Project Management and huge technical knowledge, Ronan ensures our customers and staff understand our products and services. Ronan is happiest while problem solving under pressure and is constantly planning and delivering improvements to the business for our customers. A motor racing fan, Ronan frequents Mondello Park and also enjoys striking a chord for The Blaggards.
Daniel Drennan is a talented and dedicated Software Engineer with over 25 years experience in software development in a variety of disciplines including telecoms, accountancy and database solutions. Daniel's broad experience includes 12 years working on the design, development and integration of Avaya's Audio Conferencing Systems (formally Spectel). He has also developed web-based services, voice recognition, microcontroller remote control systems and mobile device solutions. When Daniel is not at work, you will find him performing live music with a variety of bands playing popular music from the 1920's to 1980's.
Janusz is a passionate and creative Software Developer who believes 'can't is not an option'. He holds a Masters in Data Analysis as well Bachelor of Engineering (Software Engineering). Janusz is well placed to make the complex, simple and straightforward for our customers. To switch off, Janusz listens to classical music and his favourite instrument is the violin.
Lee Murphy is a graduate of DIT holding a Bsc. in Computer Science. Lee cut his teeth in Czech Republic working as a Network Engineer for AT&T. On returning to Ireland, Lee has been continuing his journey in system and network engineering with 247meeting. When Lee is not in front of a computer, he has a busy social life and his love of travelling means that he has visited close to 30 countries.
With extensive Marketing Management experience, Lara is passionate about bringing brands to life through memorable, results orientated communications. Prior to leading Marketing at 247meeting, Lara worked in global telecoms companies BT and Vodafone for over 12 years. Holding a Masters in Business Studies from UCD and a Professional Diploma from the Digital Marketing Institute, Lara brings a wealth of knowledge and insight to 247meeting. Outside of work you will find Lara looking after the social diaries of her three lovely ladies or playing tennis despite the rain.
Amy coordinates our digital content across multiple platforms, including our website and blog. She aspires to reshape what people assume by connecting the dots people least expect. Before striking out with 247meeting, she spent a year studying Restoration & Augustan Literature and Japanese in University of Limerick. Amy has gained work experience in leading companies including Google Apps, VoxPro and Compu b. In real life, Amy plays roller derby, the Shakuhachi, sketches unsuspecting commuters, and jumps head first into the nearest available mayhem.
Yiby has the art of juggling many balls in the air to a tee. Yiby secured her degree in Business Administration while working as a busy Executive Assistant in high profile agribusiness companies in Colombia. This is her first role in a technology company and she's really enjoying getting to grips with the world of communications and IT. She has been living in Ireland since 2014 and only misses the Colombian weather and exotic fruit a tad. In her downtime, Yiby is cooking, cycling or learning new things.
Justyna is dedicated to keeping our finances in impeccable order, along with our Tax returns and supplier relations. She invests her full talent and dedication to her finance projects, pushing them over the finish line with due care. After completing a Masters in International Business & Management Justyna fostered her talent for forensic data with a stint in the Missing Persons department of the British Red Cross, she pursued this talent with a qualification in Accounting and has since been with 247meeting for the past 6 years. In her personal life, Justyna aspires to great heights; she dreams of conquering mountains! A voracious reader she is fascinated by an eclectic range of subjects, like radical politics and social history.


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Richard Shenton (born 27 May 1972) was an English cricketer. He was a right-handed batsman and right-arm medium-fast bowler who played for Cheshire. He was born in Macclesfield.

Shenton, who made two appearances for the team during the 2001 Minor Counties Championship, made two appearances in the C&G Trophy in August and September 2001. Though he did not bat on his debut, he scored 29 runs in his second match.

External links
Richard Shenton at CricketArchive

1972 births
Living people
English cricketers
Cheshire cricketers
Sportspeople from Macclesfield

redpajama_set_name: RedPajamaWikipedia


By the end of 4 June, seven out of the twelve available reserve battalions of VIII Corps had been sent in to reinforce the failure of the attacks on the left and right flanks — although it has been suggested that using them to reinforce the success in the centre would have been even more disastrous. Consequently, as Bryn Hammond of the Imperial War Museum writes in a special paper on the Third Battle of Krithia, there were insufficient reserves to 'meet the Turkish forces flung against the captured positions on the following two days. As a result, those who were counter-attacked were hard pushed to hold on and the loss of the whole of Helles was a very real threat'.
The situation at the end of 7 June was that there was a slight salient in front of Twelve Tree Copse, but the 88th Brigade had had to abandon trenches H14, H13 and H12 (see map in post for 4 June). Essentially, the whole front now ran along line 11 of the trenches — the original First Objective of the battle. Only 250-500 yards had been gained on a front of about a mile. Of their original attacking force of about 34,000 troops, the Allies had lost 6500, of which 4500 were British. The Turks had lost at least 9000 men.
The 52nd (Lowland) Division was now arriving at Helles. These troops were the reinforcements promised by Kitchener at the beginning of May. On 6 June the 1/5th Battalion (Territorials) of the King's Own Scottish Borderers landed as part of this Division. In the ineffable words of the Official History, 'by an unfortunate mistake in psychology' the first task of the 1/5th KOSB was to bury the corpses of the 1st KOSB killed on 4 June, which it will be remembered were piled up as ramparts on either side of the new communication trench being dug during the Turkish counter-attacks.
The overwhelming probability is that George Calderon's body was removed by the 1/5th KOSB in this operation on 6 or 7 June. The fact that between June and September Kittie received conflicting War Office telegrams about George's fate suggests that his identity disc was not retrieved. One wonders why, but after three days in the hot sun these corpses must have been so decomposed as to necessitate burial as quickly as possible. It is most likely that he was buried at a cemetery behind Fir Tree Wood.
After the Armistice of 1918, the graves from Fir Tree Wood Cemetery were brought together with those from many other local burial grounds to form a single cemetery at the site of the original Twelve Tree Copse (see map in my post of 4 June). Of the 3360 servicemen buried or commemorated here, 2226 are unidentified. The identified men include twenty from the 1st KOSB killed on 4 June 1915. Amongst these is the commander of George Calderon's company, Captain Grogan. We may reasonably assume, then, that George's remains now rest at Twelve Tree Copse Cemetery.
This entry was posted in George Calderon, Personal Commentary, Timeline and tagged 1/5th King's Own Scottish Borderers, 52nd (Lowland) Division, Captain Grogan, comments, Dardanelles, Final days, Fir Tree Wood, Fir Tree Wood Cemetery, Gallipoli, General Kitchener, George Calderon, identity tag, King's Own Scottish Borderers, Kittie Calderon, The Great War, Twelve Tree Copse, Twelve Tree Copse Cemetery, World War I. Bookmark the permalink.


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Donald Trump, Honeymooner
Posted on September 16, 2016 by Fritz Pettyjohn
At the American Thinker, Thomas Lifson has a clip of Trump on the Tonight Show last night. He's hamming it up with the host, and he's like a pro. At one point he looks at the camera, as if to say, Am I really going to do this? He reminded me of the Great One, Jackie Gleason, when he was in his prime on The Honeymooners. He can do timing.
In the WaPo, Herr Doktor Krauthammer, who's never really cared for the guy, expresses astonishment at the New Trump. The man has a second act after all, and Herr Doktor is as amazed as I am. He's on a roll, at exactly the right time.
In the WSJ, Peggy Noonan reminds us all of the travel office scandal, and its chief victim, a guy named Billy Dale. Few people remember this story. It's from 1993, and it's Hillary Clinton at her worst. Billy died last year, but I'll bet he's got some children who could tell his story for him. Talk about a guy getting screwed over, just because he was in the way. Put his son or daughter, or widow, on camera and let them tell the story. It's something 60 Minutes would do, if they weren't partisan hacks.
Trump's talking to some veterans today, again on Fox Business, and I don't have time to watch it, but I noticed the staging. In the crowd behind him, in camera, there's a black guy, and, more importantly, over his right shoulder, a black woman. Probably a vet herself, or maybe, even better, a Gold Star mother. This is a sign of true professionalism. It was the same yesterday, at the New York Economic Club. There, over his right shoulder, in the background, was Mr. Professional, the strong right hand man, Mike Pence. He was obviously enjoying himself, and why not? Becoming Trump's VP was the smartest move he's ever made.
I tried watching a little WADR yesterday, but had to turn it off. The brass at Bloomberg and MSNBC have decided that praise of Trump will no longer be allowed. Some things are more important than maintaining a semblance of impartiality. It's game on, and all hands on deck. Trump could win, and that simply can't be allowed to happen. The media is on trial in this election. If Trump wins their credibility will, for the most part, be blown. It almost brings a tear to your eye.
Babbie's decided to try some new house cleaners. The ones she's been using are making close to $45 an hour, and aren't up to snuff. The wife of one of Darren's friends in Bozeman runs some kind of house cleaning business, with several employees. I told her what our house cleaners are making, and she said it's about the same in Bozeman. It costs Babbie's girl friends in the Bay Area about half that, but they hire illegal immigrants, so they work cheap, even in an expensive area like Piedmont. They all think Trump is a bigot because he's down on illegal immigration. But if these illegals weren't around they'd probably be hiring black women, like their mothers did. Pay someone $45 an hour, in cash, and you'd be surprised who shows up for work.
A lot of people wonder how someone like Sarah Palin could ever get elected as the Governor of a State. You have to understand Alaska in order to figure it out. The guy she beat in 2006, incumbent Republican Governor Frank Murkowski, the father of Sen. Lisa Murkowski, was unelectable after four years in office. Soupy Sales could have beaten him.
The debate's a week from Monday, and Trump's task is really simple: don't be a bully. He'll be tempted, and taunted, but he's got to keep his cool. I think he can pull it off, for one simple reason. His whole family, Ivanka included, will be there to watch. He won't let them, and especially her, down.
When a man loves a woman. Speaking of which, we're off to our nine year old granddaughter's birthday party, and soccer game. Life is good.
← The old pro
North to Alaska →

redpajama_set_name: RedPajamaCommonCrawl


ACPM has provided care for more than three decades led by the teachings and philosophy of Dr. William E. Richardson, M.D. A collection of his recordings from lectures, radio shows and interviews are available to purchase online. Email socialmanager@acpm.net for access to the digital files or click on the highlighted files below.


You didn't ask for it, but here it is anyway!
Beyond Contempt are ready to demolish your stereos, nearby stages and ear holes............. But mainly stereos with their BRAND SPANKIN new E.P. Calculated Divide.
A few old friends, (and a few new ones) have come along to ensure previous mentioned demolition including..
With a lineup this large you'd better be sure to stay hydrated, so come down nice and early.
Doors at 2p.m. And as per usual FREE and sweet tasty Dj's to keep the party going as long as it needs to.


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Pathfinder: Kingmaker is the first isometric party-based computer RPG set in the Pathfinder fantasy universe. Enjoy a classic RPG experience inspired by games like Baldur's Gate, Fallout 1 and 2 and Arcanum. Explore and conquer the Stolen Lands and make them your kingdom!
With the help of over 18,000 Kickstarter backers, Narrative Designer Chris Avellone and composer Inon Zur, Owlcat Games is proud to bring you the first isometric computer RPG set in the beloved Pathfinder tabletop universe. Enjoy a classic RPG experience inspired by games like Baldur's Gate, Fallout 1 and 2 and Arcanum. Explore and conquer the Stolen Lands and make them your kingdom!
Explore the Stolen Lands, a region that has been contested territory for centuries. Hundreds of kingdoms have risen and fallen in these lands, and now it is time for you to make your mark—by building your own kingdom! To do so, you'll need to survive the harsh wilderness and the threat of rival nations… as well as threats within your own court.
This game contains references to fantasy drugs (potions), alcohol, sex and sexual acts (no direct visualisation or nudity), along with visual gore effects. Storyline contains adult content.


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Home » Departments » Fire Department » Command Staff
Brian Roberts
Brian Roberts started his fire service career in 2002 as a fire fighter with the Brandon Fire Department. Since then, he has risen through the ranks to hold the positions of fire apparatus driver-operator, captain and battalion chief. Chief Roberts completed his basic fire fighter class 1001 in 2002 and his EMT certification the following year. With over 2000 hours of specialized training, Chief Roberts has become recognized as an expert in technical areas of structural collapse, high-angle, overland search, and swift water-dive rescue. Chief Roberts is a member of the Mississippi Office of Homeland Security Task Force II with deployments across the state. A native of Pearl, Chief Roberts is married, enjoys spending time with his family and friends and is an avid outdoorsman.
Patrick D. Wofford
Patrick D. Wofford began his fire service career in 1994 as a member of Walters Volunteer Fire Department in Pelahatchie, MS. Since then, he progressed in the ranks as a volunteer to the position of Chief of Walters Volunteer Fire Dept. Chief Wofford started with Brandon Fire Department as a fire fighter in October of 1998 after completing basic fire fighter class 1001 and EMT basic as a volunteer. Currently, Chief Wofford holds the rank of Battalion Chief with Brandon Fire Department. Prior his fire service career, Chief Wofford completed a Bachelor of Science degree at Mississippi State University. Chief Wofford is a graduate of Mississippi Executive Fire Officer Program and holds professional certifications in fire and emergency management from the Mississippi Fire Academy and National Fire Academy. During Chief Wofford's career at Brandon, he held the position of Deputy Fire Coordinator with Rankin County Fire Service. Chief Wofford is married with three children, ranging in age from 19 to 10 years of age.
Gary Huhn
Gary Huhn started with Brandon Fire Department in 2000. He holds professional certifications in fire and emergency service management from the Mississippi Fire Academy, the National Fire Academy, and the Department of Homeland Security. He specializes in technical work in directing fire suppression, fire prevention, fire training, and safety and health activities. He is currently seeking a bachelor's degree in Fire Service Management. In 2015, Gary was promoted to the rank of Battalion Chief, where he oversees the staffing of all stations, apparatus, and 16 personnel. His duties range from Incident Command System to providing the basic needs of personnel and citizens. When away from the Fire Department, Gary enjoys spending time with his family, working out, and running his business.
Carolyn Palmer
Carolyn Palmer started her fire service career in 1999 when hired on as an Administrative Assistant for the then one-year-old Municipal Brandon Fire Department. Her love of Emergency Services came from her background with her father being a volunteer firefighter for over 35 years and meteorologist for the National Weather Service. Carolyn served four years as Administrative Assistant for the fire and police department when it was combined under Emergency Services and then went back to the Fire Department in 2005. Carolyn assisted with organizing the state wide Emergency Services Administrative Professionals group which is a network and educational organization and was Secretary/Treasurer from 2015-2016. She also is a member of the Rankin County Traumatic Incident Support Team which is a support group for our first responders in the county. "Working for the City of Brandon has been extremely rewarding especially being around these fine men and women who love serving the citizens of our City."
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Brandon is consistently ranked as one of the Top 10 best places to live in Mississippi, as well as one of the Top 10 safest places to live in Mississippi. Brandon is celebrating her 193rd birthday this year, having grown from 31 residents in 1828 to over 25,000 today. Being one of the fastest growing cities in the state, people call Brandon their hometown because of the high quality of life evident throughout the community.
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Meet Maraschino! He's a lovable rabbit looking to find a calmer home where he can kick back and relax. Maraschino is a bit shy at first, but once he has time to settle in he is a very sweet little guy who loves to receive head rubs from his family. Maraschino may even like having a bunny friend in his new home – our Adoption team will help you with a meet and greet beforehand.
Does Maraschino sound like the perfect addition to your family? Stop by Animal Friends to meet him or contact our Adoption team at 412.847.7002 or AdoptionInfo@ThinkingOutsideTheCage.org.


The Envoy Max represents the same great features as the Envoy with an increased lens size for more coverage. The Italian craftsmanship is complemented with out-of-sight spring hinges and megol nose and temple pads for an unsurpassed fit and finish. ChromaPop™ polarized lenses provide the highest levels of enhanced color and clarity. Features built for performance and style for everyday life.


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Photographs (35) Apply Photographs filter
Displaying 76 - 100 of 537 items.
Gavin Rylands de Beer (1899-1972)
Gavin de Beer was an English zoologist known for his contributions to evolution and embryology, in particular for showing the inadequacy of the germ layer theory as it was then proposed. He was born in London, England, on 1 November 1899, but was raised for his first thirteen years in France where his father worked for a telegraph company. He entered Magdalen College, Oxford, in 1917 but his studies were soon interrupted by World War I. After serving in the military, he returned to Oxford where he studied under Edwin Goodrich.
Acid Dissolution of Fossil Dinosaur Eggs
Acid dissolution is a technique of removing a fossil from the surrounding rock matrix in which it is encased by dissolving that matrix with acid. Fossilized bone, though strong enough to be preserved for thousands or millions of years, is often more delicate than rock. Once a fossil is discovered, scientists must remove the fossil from its surroundings without damaging the fossil itself.
C. R. Stockard, W. E. Carrey, Robert Chambers
Format: Photographs
C. G. Wilber
Alec John Jeffreys (1950–)
Alec John Jeffreys created a process called DNA fingerprinting in the UK during the twentieth century. For DNA fingerprinting, technicians identify a person as the source of a biological sample by comparing the genetic information contained in the person's DNA to the DNA contained in the sample. Jeffreys developed the technique in the 1980s while at the University of Leicester in Leicester, UK. Jeffreys's technique had immediate applications. In forensic science, DNA fingerprinting enabled police to identify suspects of crimes based on their genetic identities.
Libbie Henrietta Hyman (1888-1969)
Libbie Henrietta Hyman was born into a recently immigrated Jewish family on 6 December 1888 in Des Moines, Iowa. One of many siblings and daughter to parents Sabina Neumann and Joseph Hyman, who did not particularly support her interests in science, Hyman excelled in school and indulged her interests in biology in her free time. From a young age, Hyman collected and cataloged flora around her home. Despite being valedictorian of her high school class, Hyman's first job was labeling cereal boxes in a local factory.
The Marine Biological Laboratory, Woods Hole, Mass. 1935
By the 1930s, the MBL had become "the" place to go during the summer for biological research and training. Luminaries such as Frank Lillie, Edmund Beecher Wilson, Edwin Grant Conklin, and Thomas Hunt Morgan took their students, packed up their families and research labs, and headed to the MBL. They worked in labs, ate together in the Mess, and they often lived in the limited on-campus housing. Life at the MBL was a life where fun, family, and science intertwined. This film, taken in 1935 by B. R. Coonfield of Brooklyn College, captures snippets of life at the MBL.
Subject: Organizations, People, Places
Whitner v. South Carolina (1997)
In the case Whitner v. South Carolina in 1997, the South Carolina State Supreme Court defined the concept of a child to include viable fetuses. This allowed grounds for prosecution of a pregnant womanÕs prenatal activity if those activities endangered or could potentially endanger the fetus within her. The case brought the issue of fetal rights versus pregnant womenÕs rights to light.
St. George Jackson Mivart (1827-1900)
St. George Jackson Mivart studied animals and worked in England during the nineteenth century. He also proposed a theory of organismal development that he called individuation, and he critiqued Charles Darwin's argument for evolution by natural selection. His work on prosimians, a group of primates excluding apes and monkeys, helped scientists better investigate the Primate group.
Leo Kanner (1894-1981)
Leo Kanner studied and described early infantile autism in humans in the US during the twentieth century. Though Eugen Bleuler first coined the term autism in 1910 as a symptom of schizophrenia, Kanner helped define autism as a disease concept separate from schizophrenia. He helped found an early child psychiatry department in 1930 at the Johns Hopkins University Hospital in Baltimore, Maryland.
Frank Rattray Lillie (1870-1947)
Frank R. Lillie was born in Toronto, Canada, on 27 June 1870. His mother was Emily Ann Rattray and his father was George Waddell Little, an accountant and co-owner of a wholesale drug company. While in high school Lillie took up interests in entomology and paleontology but went to the University of Toronto with the aim of studying ministry. He slowly became disillusioned with this career choice and decided to major in the natural sciences. It was during his senior year that he developed his lifelong interest in embryology.
Hermaphrodites and the Medical Invention of Sex (1998), by Alice Domurat Dreger
Hermaphrodites and the Medical Invention of Sex, by historian of science Alice Domurat Dreger, was published in 1998 by Harvard University Press. In the book, Dreger describes how many doctors and scientists treated human hermaphrodites from the late nineteenth century to the early twentieth century. She states that during this time period, many physicians and scientists struggled to determine the nature sex, and to support a classification of sex as male or female, many physicians and scientists resorted to viewing a person's gonads for identification of his or her sex.
Subject: Publications, Theories, Disorders
Wilhelm Roux (1850-1924)
Wilhelm Roux was a nineteenth-century experimental embryologist who was best known for pioneering Entwicklungsmechanik, or developmental mechanics. Roux was born in Jena, Germany, on 9 June 1850, the only son of Clotilde Baumbach and a university fencing master, F. A. Wilhelm Ludwig Roux. Roux described himself as an aloof child, but when he was fourteen he cultivated a passion for science that was encouraged by the director at Oberrealschule in Meiningen.
"Health Status of Vietnam Veterans III. Reproductive Outcomes and Child Health" (1988), by the US Centers for Disease Control
In 1988, the US Centers for Disease Control published 'Health Status of Vietnam Veterans III. Reproductive Outcomes and Child Health,' which summarized part of the results of the Vietnam Experience Study commissioned by US Congress to assess the health of US Vietnam veterans. They published the article in the Journal of the American Medical Association. The most heavily used herbicide in the Vietnam, Agent Orange, had previously been found to contain a contaminant linked to birth defects in rats.
Experimental Studies on Germinal Localization (1904), by Edmund B. Wilson
At the turn of the twentieth century, Edmund B. Wilson
performed experiments to show where germinal
matter was located in molluscs. At Columbia University in New York City,
New York, Wilson studied what causes cells to differentiate during
development. In 1904 he conducted his experiments on molluscs, and he modified the
theory about the location of germinal matter in the succeeding years. Wilson and others modified the
theory of germinal localization to accommodate results that showed
Nicole Marthe Le Douarin (1930- )
Nicole Marthe Le Douarin was one of the first progressive female pioneers of developmental and embryological research. Some of her most notable and ground-breaking work involves grafting quail and chicken embryos together in order to study the developmental fate of each contributing embryo. Le Douarin was born in Brittany, France, on 20 August 1930. As an only child she was inspired by her mother, a school teacher at the time, to develop a passion for learning.
Litowitz v. Litowitz (2002)
In a dispute over the allocation of cryopreserved preembryos, the Supreme Court of Washington resolved the case of David J. Litowitz v. Becky M. Litowitz (2002) by reaching a decision that neither party wanted. David Litowitz sought to find adoptive parents for two cryopreserved preembryos created during his marriage to Becky Litowitz when the couple was attempting to have children using in vitro fertilization (IVF). Becky sought to implant the preembryos in a surrogate in an effort to parent a child.
The Time Has Come: A Catholic Doctor's Proposals to End the Battle over Birth Control (1963), by John Rock
In 1963, Roman Catholic fertility doctor John Rock published The Time Has Come: A Catholic Doctor's Proposals to End the Battle over Birth Control, a first-person treatise on the use of scientifically approved forms of birth control for Catholic couples. The first contraceptive pill, called Enovid, had been on the market since June 1960, and Rock was one of the leading researchers in its development. In The Time Has Come, Rock explicitly describes the arguments for and against the use of birth control from both a religious and a scientific perspective.
Subject: Publications, Religion, Reproduction
Transposition of the Great Arteries (TGA)
Transposition of the great arteries or TGA is a potentially fatal congenital heart malformation where the pulmonary artery and the aorta are switched. The switch means that the aorta, which normally carries oxygenated blood, carries deoxygenated blood. There are two types of the malformation, d-TGA where no oxygen reaches the body and l-TGA where some oxygenated blood circulates. In the US, the Centers for Disease Control estimate that about 1,901 infants are born each year with TGA, or about one for every 2,000 births.
The Source-Sink Model
The source-sink model, first proposed by biologist Francis Crick in 1970, is a theoretical system for how morphogens distribute themselves across small fields of early embryonic cells. A morphogen is a substance that determines the fate and phenotype of a group of cells through a concentration gradient of itself across that group. Crick's theory has been experimentally confirmed with several morphogens, most notably with the protein bicoid , the first discovered morphogen. The model provides a theoretical structure for the understanding of some features of early embryonic development.
Subject: Theories
Park v. Chessin (1977)
The New York Appellate Court ruled on 11 December 1977 in favor of Steven and Hetty Park and against Herbert Chessin for the wrongful life of the Parks' child. In a wrongful life case, a disabled or sometimes deceased child brings suit against a physician for failing to inform its parents of possible genetic defects, thereby causing harm to the child when born. Park v. Chessin was the first case to rule that medical personnel could be legally responsible for wrongful life. Further cases such as the 1979 case Berman v. Allan and the 1982 case Turpin v.
Commonwealth v. Luceba Parker [Brief] (1845)
The Court settled the question left open from the case of Commonwealth v. Bangs that it must be proved a woman was "quick with child" in order for abortion prohibitions to have any effect in Massachusetts.
Summerfield v. Superior Court [Brief] (1985)
Arizona joined the majority of states that recognized wrongful death claims on behalf of a viable fetus, regardless of whether the child was born alive or died in the womb by expanding the definition of "person" to include a viable fetus.


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Organizers want breakdancing at the 2024 Paris Olympics
By Caitlin O'Kane
February 22, 2019 / 5:08 PM / CBS News
Boomboxes could be considered sports equipment at the 2024 Paris Olympics. Organizers want breakdancing to become an Olympic sport, in hopes of appealing to younger audiences, The Associated Press reported.
However, the final decision on which events will be showcased during the Summer Games won't come for a while. The International Olympic Committee (IOC) will make the call after the 2020 Olympics in Tokyo.
Still, the proposal to include breakdancing was applauded as a milestone by those who practice the style of dance. "It's a victory for us," said Mounir Biba, a prominent breakdancer in France, the AP reported. "Even if it goes no further, we'll still have won."
Many hope inclusion in the summer games will boost global acceptance of breakdancing as a competitive sport.
"There's simply no doubt about the athletic aspects of the discipline," Biba said.
Breakdancing, which was featured at the Youth Olympic Games last year, consists of solo or teams of "breakers" facing off in battles. The different teams take turns showing off their dance moves and acrobatic tricks. A judging panel picks the winners.
Climbing, surfing and skateboarding will all make their Olympic debuts at the 2020 Tokyo Games. However, sports like karate and squash, which lobbied for spots, were out of luck, Tony Estanguet, the head of Paris' organizing committee, announced on Thursday, the AP reported.
France's b-boy Martin competes during a battle at the Youth Olympic Games in Buenos Aires, Argentina, on Oct. 8, 2018. Getty
First published on February 22, 2019 / 5:08 PM


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Hundreds show up for Regina's first-ever walk for congenital adrenal hyperplasia, a rare genetic disorder
Ten-month-old Carlin Foley looks like any normal happy and healthy baby, but unlike babies, every eight hours he needs medicine to help...
London resident to receive Order of Ontario
A Londoner will receive Ontario's highest honour on Wednesday at Queen's Park. Robert Pio Hajjar, an advocate for persons with disabilities, will...
United Way Halton-Hamilton opens new Burlington location as part of amalgamation
The United Way is looking at the launch of its Burlington office as the official kick-off to a newly amalgamated organization. The...
Hospital Home Lottery is back with a new grand prize showhome
One of the biggest fundraisers for Saskatoon's hospitals is back for another year with a brand new showhome. The $1.3 million showhome located in...
In Photos: Foodies converge on Commonwealth Stadium for Feast on the Field
Normally, when people take to the field at Edmonton's Commonwealth Stadium they don helmets and knee pads but on Wednesday night, knives...
United Way of Central & South Okanagan Similkameen launches 2017/2018 campaign
The United Way of Central & South Okanagan Similkameen supports about 85,000 people in the region through 51 agencies that offer programs...
Kingston, Frontenac, Lennox and Addington United Way reveals 2017 fundraising goal
Sadie Augustyn, 15, spoke to a crowd of several hundred United Way supporters at the annual campaign kickoff in Kingston, on Friday. Augustyn...
Money for childhood cancer research almost stolen at Saskatoon fundraiser
Organizers are now considering better security at their fundraisers for childhood cancer research following an attempted theft this past weekend in Saskatoon. The third...
Kids organize bake sale to give back to Montreal Children's Hospital
On Friday, a group of six Montreal-area kids — between the ages of four and nine, handed over an $835 check to...
Jonathan Drouin makes a hefty donation to Montreal's CHUM hospital
Twenty-two-year-old Montreal Canadien Jonathan Drouin hasn't even played a game with the team yet but he is already giving back to his...
Fit Row


The air traffic control announcement Monday is the start of a "infrastructure week" planned by the Trump administration. The organisation, which supported a similar proposal a year ago, said it believes more reliable funding streams are critical, but wants to see "specifics".
Still, Trump might not want to fire Sessions for the simple reason that he might have an awfully tough time getting a replacement through the Senate. Both versions of Trump's travel ban have been blocked by federal courts. On Monday morning, Trump also continued his crusade against the Department of Justice's role in implementing his immigration executive order that was twice struck down nationwide by appeals courts.
If Attorney General Jeff Sessions' future in the Trump administration is safe, the White House certainly isn't letting on. Sessions had suggested in the past several weeks he might resign amid the widening discord, according to another US official.
Michael Bates, the law enforcement official who extracted thousands of messages from phones belonging to Roy and Carter. According to testimony from this week, on July 12, 2014, the day of Roy's suicide, Carter texted a classmate, "He just called me and there was a loud noise like a motor ..." On July 3, 2014, Carter texted: "Are you gonna do it tonight?" I thought you really wanted to die, but apparently you don't.
The key issue before the Senate Intelligence Committee was whether Trump sought to obstruct the investigation in nine conversations with Comey this year, leading up to his dismissal of the FBI chief on May 9. In his opening statement , Comey somberly accused the Trump administration of spreading "lies, plain and simple" in the aftermath of his abrupt ouster, declaring that the administration "chose to defame me and, more importantly, the FBI" by claiming the bureau was in disorder.
The Humane Society of Midland County does not euthanize due to overcrowding. "They'll love her. It will be hard not to", said Sizer. Almost 200 at-risk dogs and cats have been flown to the Pacific Northwest so they can find forever homes.
There was conflicting information on the number of people on board the Shaanxi Y8 plane when it disappeared, but in the latest update the military said it was carrying a total of 122 people. The plane lost contact 29 minutes after take-off while flying at 18,000 feet (5,485 metres) over the Andaman Sea, an earlier military statement said, adding that a Burmese air force patrol had spotted evidence of oil on the surface of the water 16 miles from the port of Dawei, Tenasserim Division.
Last August, the government announced it had executed a number of Kurdish Islamic extremists from a group known as Towhid and Jihad after convicting them of armed robbery, killing civilians and planning bomb attacks . The two countries don't maintain diplomatic relations, and the Trump administration has emphasized the need to counter Iran's influence. "They look for a way to destabilize our country".
Donald Trump Jr. joined his father in criticizing London Mayor Sadiq Khan in an interview that aired Tuesday on ABC. Khan told Channel 4 that there were " many things" that the US President was wrong about, and that the state visit should not go ahead.
We know this not merely from the text but because Comey actually did not interpret anything said as obstruction of justice . Trump's personal attorney delivered a full-throated statement shortly after the hearing and flatly denied that the president asked Comey for loyalty or to let Michael Flynn go.
In written remarks submitted to the Senate Intelligence Committee on Wednesday - a day before his much-anticipated testimony - Comey said he remembered nine separate private conversations with President Trump . "I replied only that 'he is a good guy'". HEINRICH: Did Director Comey ever share details of his conversations with the president with you. Both men declined to answer the questions, leading to tense exchanges.


If you are on a gluten free diet, here are some guidelines and suggestions for adapting and creating recipes. Start with recipes that have little flour or items with gluten since sometimes the flour can be simply eliminated from the recipe such as when you bread or flour fish or meats. Focus on the main flavors and highlight recipe ingredients that can be a problem.
While gaining new skills, stick with simple vegetables and fruits. Use recipes that start from scratch to make gravies and sauces that are often used in soups, stews, and casseroles. Commercial gluten free substitutes can be found. Practically any recipe can be altered or adapted to become gluten free.


text:
#include "cms_thread.h"
#include "cms__thread.h"
#include "os_heap.h"
#include "os_report.h"
#include "os_thread.h"

cms_thread
cms_threadNew(
    const c_char* name,
    os_threadAttr * attr)
{
    cms_thread thread;
    thread = os_malloc(sizeof *thread);
    cms_object(thread)->kind = CMS_THREAD;
    if (!cms_threadInit(thread, name, attr)){
        os_free(thread);
        thread = NULL;
    }
    return thread;
}

c_bool
cms_threadInit(
    cms_thread thread,
    const c_char* name,
    os_threadAttr * attr)
{
    c_bool retValue = FALSE;
    if(thread != NULL){
        if(name != NULL){
            thread->ready = TRUE;
            thread->terminate = FALSE;
            thread->results = NULL;
            thread->name = name;
            thread->did.id[0] = '\0';
            thread->uri = NULL;
            retValue = TRUE;
            if (attr != NULL) {
                thread->attr = *attr;
            } else {
                os_threadAttrInit(&thread->attr);
            }
        } else {
            OS_REPORT(OS_ERROR, CMS_CONTEXT, 0, "cms_threadInit failed. (no name supplied)");
        }
    } else {
        OS_REPORT(OS_ERROR, CMS_CONTEXT, 0, "cms_threadInit failed.");
    }
    return (retValue);
}

void
cms_threadDeinit(
    cms_thread thread)
{
    os_result osr;
    os_threadId self;

    if(thread != NULL){
        thread->terminate = TRUE;

        self = os_threadIdSelf();

        /* Only wait on exit when the thread that calls this routine does not
         * wait for itself.
         */
        if(os_threadIdToInteger(self) != os_threadIdToInteger(thread->id)){
            osr = os_threadWaitExit(thread->id, NULL);

            if(osr != os_resultSuccess){
                OS_REPORT(OS_ERROR, CMS_CONTEXT, 0,
                            "Thread '%s' waitExit failed.", thread->name);
            }
        }
    }
}

c_bool
cms_threadStart(
    cms_thread thread,
    void *(* start_routine)(void *),
    void *arg)
{
    os_result osr;
    c_bool success;

    success = TRUE;
    osr = u_serviceThreadCreate(&thread->id, thread->name, &thread->attr, start_routine, arg);

    if(osr != os_resultSuccess){
        OS_REPORT(OS_ERROR, CMS_CONTEXT, 0, "cms_threadStart failed.");
        success = FALSE;
    }
    return success;
}

void
cms_threadFree(
    cms_thread thread)
{
    if(thread != NULL){
        cms_threadDeinit(thread);

        if (thread->uri != NULL) {
            os_free(thread->uri);
        }
        os_free(thread);
        thread = NULL;
    }
}

redpajama_set_name: RedPajamaGithub


Price: $11 adult daily tickets $16 weekend pass Discounts for college students and children [OR if room, replace with: $8 college students, $5 ages 12–17] Kids under 12 free Discounted advance tickets available thru the website.
@ Skyline High School, 2552 N Maple Rd.
Over 150 vendors of holistic & metaphysical products and services, card readers, mediums, medical intuitives, aura photography, energy work, crystals, jewelry, essential oils, CBD oil, and all kinds of holistic health and spiritual offerings. FREE presentations with Expo admission. Gallery readings with messages from loved ones in spirit for many audience members. Quiet, private Reader Room with concierge service! Sponsored by Crazy Wisdom Bookstore & Tea Room, Body Mind Spirit Guide, Enlightened Soul Center, and Earth Elements. More details and buy discounted advance tickets at EnlightenedSoulExpo.com.


text:
package gt

import (
	"fmt"
	"regexp"
	"strconv"
	"strings"

	"github.com/gyuho/gson/jgd"
)

// Graph is a graph represented in adjacency matrix.
type Graph struct {
	Size   *int
	Matrix [][]float64

	// to look up the index of vertex
	Index map[string]int

	// to look up the string label from index
	Label map[int]string
}

// NewGraph returns a new graph in adjacency matrix.
// It returns the adjacency matrix of the size * size.
func NewGraph(size int) *Graph {
	make2DSlice := func(row, column int) [][]float64 {
		mat := make([][]float64, row)
		// for i := 0; i < row; i++ {
		for i := range mat {
			mat[i] = make([]float64, column)
		}
		return mat
	}
	mat := make2DSlice(size, size)

	// to initialize
	for r := range mat {
		for c := range mat[r] {
			mat[r][c] = 0.0
		}
	}
	lm := make(map[string]int)
	ls := make(map[int]string)
	return &Graph{&size, mat, lm, ls}
}

// ParseToGraph parses string data to return a new graph.
func ParseToGraph(str string) *Graph {
	validID := regexp.MustCompile(`\t{1,}`)
	str = validID.ReplaceAllString(str, " ")
	str = strings.TrimSpace(str)
	lines := strings.Split(str, "\n")

	// to count the labels
	lc := make(map[interface{}]int)
	for _, line := range lines {
		fields := strings.Split(line, "|")
		lc[fields[0]] = 1
		for _, field := range fields {
			elems := strings.Split(field, ",")
			if elems[0] != "" {
				lc[elems[0]] = 1
			}
		}
	}
	size := len(lc)

	g := NewGraph(size)
	*g.Size = size

	cn := 0
	for key := range lc {
		id := fmt.Sprintf("%s", key)
		g.Index[id] = cn
		g.Label[cn] = id
		cn++
	}

	// Make sure we have all the Lookups
	// before we begin this
	for _, line := range lines {
		fields := strings.Split(line, "|")
		srcID := fields[0]
		edgepairs := fields[1:]

		for _, pair := range edgepairs {
			if len(strings.Split(pair, ",")) == 1 {
				// to skip the lines below
				// and go back to the for-loop
				continue
			}
			dstID := strings.Split(pair, ",")[0]
			weight := strToFloat(strings.Split(pair, ",")[1])
			g.AddEdge(srcID, dstID, weight)
		}
	}
	return g
}

// GetVertices returns the slice of vertices.
func (g Graph) GetVertices() []string {
	result := []string{}
	for k := range g.Index {
		result = append(result, k)
	}
	return result
}

// GetVerticesSize returns the size of vertices.
func (g Graph) GetVerticesSize() int {
	return *g.Size
}

// GetEdgesSize returns the size of edges.
func (g Graph) GetEdgesSize() int {
	size := g.Size
	cn := 0
	// traverse the 2D slice
	for r := 0; r < *size; r++ {
		for c := 0; c < *size; c++ {
			if g.Matrix[r][c] != 0.0 {
				cn++
			}
		}
	}
	return cn
}

// GetEdgeWeight returns the value of the matrix
// which is the edge weight value from A to B.
func (g Graph) GetEdgeWeight(A, B string) float64 {
	a, _ := g.Index[A]
	b, _ := g.Index[B]
	return g.Matrix[a][b]
}

// AddEdge adds an edge with the weight value.
// The edge goes from A to B, not B to A.
func (g *Graph) AddEdge(A, B string, val float64) {
	a, _ := g.Index[A]
	b, _ := g.Index[B]
	g.Matrix[a][b] = val
}

// RemoveEdge removes an edge from A to B, not B to A.
func (g *Graph) RemoveEdge(A, B string) {
	a, _ := g.Index[A]
	b, _ := g.Index[B]
	g.Matrix[a][b] = 0.0
}

// HasEdge returns true if there is an edge
// from A to B.
func (g Graph) HasEdge(A, B string) bool {
	a, ok1 := g.Index[A]
	if !ok1 {
		// panic("The vertex does not exist in the graph.")
		return false
	}
	b, ok2 := g.Index[B]
	if !ok2 {
		// panic("The vertex does not exist in the graph.")
		return false
	}
	if g.Matrix[a][b] == 0.0 {
		return false
	}
	return true
}

// GetInVertices returns the vertices that goes into A.
func (g Graph) GetInVertices(A string) []string {
	a, ok1 := g.Index[A]
	if !ok1 {
		panic("The vertex does not exist in the graph.")
	}

	result := []string{}
	for i := 0; i < g.GetVerticesSize(); i++ {
		if g.Matrix[i][a] != 0.0 {
			result = append(result, g.Label[i])
		}
	}

	return result
}

// GetOutVertices returns the vertices that goes out of A.
func (g Graph) GetOutVertices(A string) []string {
	a, ok1 := g.Index[A]
	if !ok1 {
		panic("The vertex does not exist in the graph.")
	}

	result := []string{}
	for i := 0; i < g.GetVerticesSize(); i++ {
		if g.Matrix[a][i] != 0.0 {
			result = append(result, g.Label[i])
		}
	}

	return result
}

// Initialize initializes the elements of matrix with num.
func (g *Graph) Initialize(num float64) {
	mat := g.Matrix
	for r := range mat {
		for c := range mat[r] {
			mat[r][c] = num
		}
	}
}

// OutputMatrix outputs the matrix of Graph in string format.
func (g Graph) OutputMatrix() string {
	return Output2DSlice(g.Matrix)
}

// Output2DSlice outputs the matrix in string format.
func Output2DSlice(mat [][]float64) string {
	s := ""
	for r := range mat {
		for c := range mat[r] {
			// to exclude trailing white space chracter
			if c != len(mat[r])-1 {
				if mat[r][c] < 10 {
					s += "  " + strconv.FormatFloat(mat[r][c], 'f', -1, 64) + " "
				} else if mat[r][c] < 100 {
					s += " " + strconv.FormatFloat(mat[r][c], 'f', -1, 64) + " "
				} else {
					s += strconv.FormatFloat(mat[r][c], 'f', -1, 64) + " "
				}
			} else {
				if mat[r][c] < 10 {
					s += "  " + strconv.FormatFloat(mat[r][c], 'f', -1, 64)
				} else if mat[r][c] < 100 {
					s += " " + strconv.FormatFloat(mat[r][c], 'f', -1, 64)
				} else {
					s += strconv.FormatFloat(mat[r][c], 'f', -1, 64)
				}
			}
		}
		s += "\n"
	}
	return s
}

// strToFloat converts string to float64.
func strToFloat(str string) float64 {
	f, err := strconv.ParseFloat(str, 64)
	if err != nil {
		fmt.Println(err.Error())
		panic("Fail")
	}
	return f
}

// JSONGraph parses JSON file to a graph.
func JSONGraph(filename, graph string) *Graph {
	nodes := jgd.GetNodes(filename, graph)
	gmap := jgd.MapGraph(filename, graph)
	// map[string]map[string][]float64

	g := NewGraph(len(nodes))
	*g.Size = len(nodes)

	cn := 0
	for _, node := range nodes {
		g.Index[node] = cn
		g.Label[cn] = node
		cn++
	}

	for _, srcID := range nodes {
		for dstID := range gmap[srcID] {
			for _, weight := range gmap[srcID][dstID] {
				g.AddEdge(srcID, dstID, weight)
			}
		}
	}
	return g
}


text:
The Byte
Introducing Deetox.com – Your pocket digital well-being assistant.
Deetox.com was born in the early days of the COVID-19 pandemic when lockdown impositions were swiftly changing the world as we knew it. Deetox.com founder and digital entrepreneur, Dinesh Lalvani, acknowledged the unintended consequences to mental health and physical well-being, and recognised that good health and positivity could help make lives a lot more livable in these challenging times.
The Deetox.com website and Android and iOS app connect a broad range of users across age-groups, content preferences and geographies, becoming a go-to resource for 'happy distractions' – a mix of positive, productive and motivating content.
'The happy hub' (app-only) reminders encourage users to undertake a healthy, fun or productive activity, and earn a delightfully witty and colourful badge for each completed task.
The 'Well-being' blog features DIY and productivity articles, content for family and kids, lifestyle, entertainment, health, humour and lots more.
'Challenges' keep the growing Deetox.com community engaged through periodic fun competitions entailing exciting prizes and social media fame. Deetox.com recently partnered with a charity initiative – the first of many more to come – to raise awareness and funds for underprivileged children hit hardest by the pandemic.
Deetox.com continues to gain a following among anyone who seeks positivity and a balance of work, life, health and happiness in a time of unpredictability. We'll continue to engage our community with tips, tools and features for staying fit, having fun online with family and friends, and encouraging well-being habits.
"These are unprecedented times. Now more than ever we have to focus on our mental health and well-being to be the best we can be." Dinesh Lalvani, Founder – Deetox.com
About Deetox
At Deetox.com, we do our best to bring you everything you need to get through the day during the lockdown. We know it's no walk in the park having to stay at home, but we're here to make it that bit easier by keeping you entertained and bringing you the best well-being tips.
For information, questions, collaboration or sponsorship queries, reach out to us info@growl.ie
Category // Press Release
Tags // Happiness, Mindfulness, Mobile App, Self Care, Website
PreviousArt Deccani. Blending Art Deco & Deccan Art.
NextIntroducing COVID-19 ready online pub booking system
© 2021 Growl Media Limited. All Rights Reserved.


text:
Black, Gay, Stuck at Home? The Black LGBTQ Watchlist You Need
Let's face it, we're all quarantined and dealing with the reality of COVID-19 the best we can. If nothing else, this pandemic has given us an opportunity to binge watch our little hearts out. But with so many movie and TV show options on several different streaming platforms, you can find yourself losing precious time by trying to decide what to watch. Take a deep breath. We've done the leg work for you and have compiled a list of some of the best LGBT movies and TV shows, many of which center characters of color. Take a look.
AJ & The Queen (Series)
While traveling across the country in a run-down RV, drag queen Ruby Red discovers an unlikely sidekick in AJ: a tough-talking 10-year-old stowaway.
Starring:RuPaul Charles, Izzy G., Michael-Leon Wooley
Creators:RuPaul Charles, Michael Patrick King
Moonlight (Movie)
In this acclaimed coming-of-age drama, a young man who grows up poor, black and gay in a rough Miami neighborhood tries to find his place in the world.
Starring: Jharrel Jerome, Andre Holland, Mahershala Ali
The Death and Life of Marsha P. Johnson (Documentary)
As she fights the tide of violence against trans women, activist Victoria Cruz probes the 1992 death of her friend Marsha P. Johnson.
The Perfection (Movie)
This 2018 thriller has a little bit for everyone, bone-chilling suspense, classical music and lesbian themes that heat up the screen.
Starring: Allison Williams, Logan Browning
Paris Is Burning (Movie)
Tangerine (Movie)
This is like no Christmas Eve you have ever seen as a trans sex worker rips through Hollywood looking for a "skanky ho" and her cheating Chester.
Naz & Maalik
And created with you in mind...Michael Ward and Joshua Henry Jenkins, creators of the film series; "Black, Gay, Stuck at Home—will be screening the Maurice Jamal indie hit, "Dirty Laundry" on Friday, April 24, 2020. You can register for the Zoom screening here.
Note: This is a preliminary list and will be updated periodically.
The T


A group of protesters, Monday, stormed the headquarters of the Independent National Electoral Commission (INEC) in Osun state to oppose a rerun of governorship election ordered by the commission.
This is following INEC's declaration of the State governorship election as inconclusive after the margin between the two leading contenders in the poll was lower than the number of invalid votes.
The rerun election will be held on Thursday at 7 polling units where votes were cancelled.
The protesters condemned INEC for not declaring Adeleke the winner of the poll having scored the highest number of votes in the poll.
They said the decision made by INEC on the just concluded governorship election is not supported by the people of the state, therefore, INEC should declare Adeleke, who led in vote counts difference of 353 as the elected governor of the state.


text:
Virus detectives test whole-body scans in search of HIV's hiding places
Antiretroviral drugs have transformed HIV infection from a death sentence to a chronic condition for many people who carry the virus. But because HIV never truly leaves the body, the virus rebounds rapidly if patients stop taking the drugs for even a short time.
Now scientists are trying to figure out how, and where, HIV hides when blood tests show that a person's viral load is low or undetectable. The location of this reservoir has long been a mystery, but that could soon change. Powerful new techniques are giving researchers an unprecedented look at how HIV travels though the bodies of people and animals — turning up clues to the virus's hiding places and new targets for future therapies.
HIV is a challenging foe because it integrates into the DNA of its host cells. Some scientists argue that a true cure would require removing all traces of the virus's DNA from the body, rather than simply preventing HIV from hijacking cells to replicate itself — and that goal may be unreachable. "We are starting to realize that getting rid of all the HIV DNA is not completely realistic," says Sara Gianella, an infectious-disease researcher at the University of California, San Diego.
The best researchers can hope for might be to permanently silence or contain HIV after infection, says Gianella, who presented new findings on HIV's hideouts at a meeting last week organized by the US National Institutes of Health (NIH). Antiretroviral drug cocktails (known as ART) suppress the virus in immune cells in the blood — but the first results from Gianella's "Last Gift" study confirm that HIV can stash itself within immune cells in dozens of types of tissue.
The project examines bodies donated by people with HIV who enrol when they are within six months of death from unrelated conditions. All participants are on ART when they sign up for the study, but some are asked to stop taking the drugs. Gianella's team collects blood samples while donors are alive, and about 50 different types of tissue after death. The samples from people who stopped ART show where HIV has rebounded, while samples from people who continued the drugs can provide information about the virus's reservoir.
The researchers did not detect HIV in the blood of their first donor, who continued taking antiretroviral drugs until his death. But they did find viable virus in nearly all of the 26 tissues they examined after the man died.
Janice Clements, a pathobiologist at Johns Hopkins University in Baltimore, Maryland, calls the project "amazing". After a person with HIV dies, she says, researchers can rarely acquire tissue samples quickly enough to measure the level of virus present, and they usually don't know whether the dead person had been taking antiretroviral drugs.
Clements' research has shown that HIV tends to linger in the brain and cause neurological problems, because most antiretroviral drugs can't cross the blood–brain barrier. At the meeting, Clements and her colleagues presented the first evidence that simian immunodeficiency virus (SIV), which is closely related to HIV, survives in the spinal cord of macaques taking antiretroviral drugs and spreads quickly after the animals stop the drugs. "This is unlike any virus we've cured," she says.
Nicolas Chomont, a virologist at the University of Montreal in Canada, says that HIV's behaviour in tissues known to be part of the reservoir is complex, with virus levels going up and down. "People will tell you the reservoir is everywhere, and that might be true," he says. "Even if it's true, we need to understand if [the virus] in the brain and the big toe are the same."
Tracking these patterns over time might require researchers to detect traces of HIV in the reservoirs of living people — a daunting task. "For these very rare events, you need to know where to look," says Thomas Hope, a cell biologist at Northwestern University in Evanston, Illinois.
At the NIH meeting, Hope presented a new imaging technique in macaques infected with SIV. The researchers inject the animals with antibodies that bind to the virus, which makes it visible in positron-emission tomography (PET) scans of the monkeys' bodies.
The approach has revealed that SIV spreads through mucosal cells in the animals' guts and lymph nodes within hours of infection. Hope has begun to treat infected macaques with ART to determine where and how quickly the drugs lower their levels of SIV. After six months of treatment, the researchers plan to stop the treatment and scan the monkeys to see where the virus has rebounded.
And later this year, another team will begin one of the first PET imaging studies of people with and without HIV in their blood, using a different antibody. Timothy Henrich, an infectious disease researcher at the University of California, San Francisco, who is directing the study, says that his group hopes to measure what happens when people on ART stop taking the drugs and the virus rebounds. Gianella's team also wants to test PET imaging in Last Gift participants.
Ultimately, working out where HIV rebounds from will require more than just measuring the virus in blood, Hope says. Blood immune cells are "going to be a more minor player compared to the dark matter reservoir which we haven't really defined yet", he says. "We know it's there."
Published by www.nature.com on October 19, 2018


A Portrait of Southland is a personal view of the Region in watercolour by Ron Esplin.
The exhibition opens with an afternoon tea at 3PM on Saturday 12 July 2014 at the Green Island Gallery, 194 Main South Road Green Island.
Southland is the most sparsely populated Southern region of New Zealand. It is famed for native bird sanctuaries and an untouched natural environment. A quarter of Southland's land area is protected as part of the Fiordland and Rakiura national parks, and conservation and sustainability projects are key activities.
The largest city of Invercargill is a laid back town with a Scottish heritage but like the rest of Southland it takes a little while to learn to love. Other centres tend to be smaller such as Gore and Mataura, and many towns are quite rural and quaint such as Mataura, Riverton, Winton, and Tuatapere. But the region is at once charming and majestic. Charming as in the little fishing village of Cosy Nook for example, and majestic as in the towering Southern Alps to the West sheltering lakes such as Manapouri and Hauroko, the deepest lake in New Zealand.
I have put together a twenty page book featuring 34 paintings and editorial about Southland and the subjects featured. Many of the original paintings are included in the exhibition, and the book will be available for sale at the Gallery.
I compiled the book over some time, and when I came to the point of holding the exhibition with the assistance of Green Island Gallery Director Genny Hanning, I discovered that a number of paintings had been sold. What to do? Well for the first time in my life I decided to reproduce some of the paintings, a fascinating exercise and of course an impossible one. The puzzle is for you to see if you can pick out the paintings that I have reproduced. They are different, and original paintings in their own right and not too difficult to identify, but a fun exercise.
Click on the link below to view the website invitation.
Invitation to "A Portrait of Southland"


text:
package net.lospi.juno.estimation.mh;

import net.lospi.juno.elements.Chain;
import net.lospi.juno.estimation.proposal.Proposal;
import net.lospi.juno.estimation.proposal.ProposalGenerator;
import net.lospi.juno.model.Model;
import net.lospi.juno.stat.BooleanDistribution;
import org.testng.annotations.BeforeMethod;
import org.testng.annotations.Test;

import static org.fest.assertions.api.Assertions.assertThat;
import static org.mockito.Matchers.any;
import static org.mockito.Mockito.*;

@Test(groups="unit")
public class SimpleMetropolisHastingsIteratorIteratorTest {
    private ProposalGenerator proposalGenerator;
    private BooleanDistribution booleanDistribution;
    private SimpleMetropolisHastingsStepBuilder simpleMetropolisHastingsStepBuilder;
    private Chain state;
    private Model model;
    private SimpleMetropolisHastingsStep expected;
    private Proposal proposal;
    private double logAcceptProbability;
    private SimpleMetropolisHastingsStepBuilder.Stub builderStub;

    @BeforeMethod
    public void setUp(){
        state = mock(Chain.class);
        model = mock(Model.class);
        proposalGenerator = mock(ProposalGenerator.class);
        booleanDistribution = mock(BooleanDistribution.class);
        simpleMetropolisHastingsStepBuilder = mock(SimpleMetropolisHastingsStepBuilder.class);
        expected = mock(SimpleMetropolisHastingsStep.class);
        proposal = mock(Proposal.class);
        builderStub = mock(SimpleMetropolisHastingsStepBuilder.Stub.class);
        logAcceptProbability = -1d;

        when(proposalGenerator.generate(state, model)).thenReturn(proposal);
        when(simpleMetropolisHastingsStepBuilder.with()).thenReturn(builderStub);
        when(builderStub.model(model)).thenReturn(builderStub);
        when(builderStub.proposal(proposal)).thenReturn(builderStub);
        when(builderStub.state(state)).thenReturn(builderStub);
        when(builderStub.build()).thenReturn(expected);

        when(proposal.getLogAcceptanceProbability()).thenReturn(logAcceptProbability);
    }

    public void nextAccept() throws Exception {
        when(booleanDistribution.nextWithLogProbability(logAcceptProbability)).thenReturn(true);
        when(builderStub.accepted(true)).thenReturn(builderStub);

        SimpleMetropolisHastingsIterator iterator = new SimpleMetropolisHastingsIterator(proposalGenerator, booleanDistribution, simpleMetropolisHastingsStepBuilder);
        MetropolisHastingsStep result = iterator.next(state, model);
        assertThat(result).isEqualTo(expected);

        verify(proposal).update(state);
        verify(builderStub).model(model);
        verify(builderStub).proposal(proposal);
        verify(builderStub).state(state);
    }

    public void nextReject() throws Exception {
        when(booleanDistribution.nextWithLogProbability(logAcceptProbability)).thenReturn(false);
        when(builderStub.accepted(false)).thenReturn(builderStub);

        SimpleMetropolisHastingsIterator iterator = new SimpleMetropolisHastingsIterator(proposalGenerator, booleanDistribution, simpleMetropolisHastingsStepBuilder);
        MetropolisHastingsStep result = iterator.next(state, model);
        assertThat(result).isEqualTo(expected);

        verify(proposal, never()).update(state);
        verify(builderStub).model(model);
        verify(builderStub).proposal(proposal);
        verify(builderStub).state(state);
    }
}


Oooh I like the time travel option, it's definitely necessary. For Friday, someone with sassiness like 80's era Nadine Garner, or Melissa Howard who played Rebecca in Dead Gorgeous, that ABC TV show about Victorian ghosts.
For Tina Valentina I'd love an actress who was a big name in the 80s-90's for that authentic cred – like Claudia Black or Lucy Lawless. Justine Clarke, maybe?
Actually all three of those might be slightly too young, we can also go forward in time, yes?
There are so many options for Griff but my head settled on 90's Matt Day and I can't go past that.
Caitlin Stacey is my favourite of everything, I was thinking Solar but actually I can see her as Astra. Clearly I'd have to write her an Astra story to give her a bigger part.
Isla Fisher and Rose Byrne could fight it out for who gets to be Megadethra.
Rachael Taylor as Danni/former Catsuit. Yes, I'm pretty much casting just the women here.
I think Celia Pacquola would do a good job of Astra III.
I want people who have read the story to come back and fill in the blanks here!
Fun, snarky, heroic, action-packed and loving.
I adore the relationship between Hawkeye and Hawkeye in Marvel comics. The way that Clint Barton dealt with a young woman taking his name and superhero identity while he was dead/out of town… at first he was determined to put her in her place, but they became a great team, and he happily shares the name and status with her instead of insisting he is senior. I like the way that their mentor-mentee relationship is often quite broken and sibling-y because he's less competent at life than she is. So great.
5. What song reflects a theme, character or scene in your book?
Ha this is a ridiculously hard question for me. The Press Gang theme music? All the Crazy Ex Girlfriend theme songs as sung by Megadethra? Remy Zero's 'Save Me', still the absolute best creative decision made by the Smallville production team? Ooh NO I know what it is. It's totally the Birds of Prey song from Batman: The Brave and the Bold.
(but an honourable mention to this version of Bonnie Tyler's Holding out for a Hero, as performed by Melissa Benoist on Glee.
Tansy Rayner Roberts is an award winning blogger, podcaster and fantasy author. She co-hosts the Galactic Suburbia and Verity! podcasts, and is well known for writing feminist commentary on pop culture including superhero comics and Doctor Who.


The funding will allow the state-of-the-art facility in Windsor, Que., to double its annual production to produce 300 tonnes of nanocrystals a year. Extracted from wood fibre, the nanocrystals can be used in everything from papers to paints, electronics to adhesives and cement to cosmetics.
"CelluForce has been working hand in hand with industrial partners, helping them develop high-performance and sustainable products using cellulose nanocrystals," CelluForce CEO Sébastien Corbeil said in a news release. "This investment will allow us to maintain our leadership in the field and expand the development of improved products with our customers. It will further enable our continued growth."
The federal funding is provided through Natural Resources Canada's Investments in Forest Industry Transformation (IFIT) program, and the provincial funding is through Quebec Minister of Forests, Wildlife and Parks' Innovation Bois [wood innovation] program and the Ministère de l'Économie et Innovation's Fonds du développement économique [economic development fund].
The increase in capacity is expected to help create more than 100 jobs.
"This project is a terrific example of the brighter, bio-based future ahead of us. Congratulations to CelluForce for leading the way in forest sustainability and providing eco-friendly development solutions in Canada," Paul Lefebvre, parliamentary secretary for Natural Resources Canada, said in the release.


The students who can apply for the Portuguese Studies BA Program are expected to present the documentation of their certificate of matriculation from a secondary school and to submit their application with the necessary attachments.
B2 level Portuguese language proficiency.
The students of Portuguese after 3 years of training have a reliable knowledge of Portuguese language (level B2, C1) and the Portuguese language cultures, so they can get a job in transnational companies, in the tourist industry, in the foreign trading, in different mass media forums, or as translators and interpreters.


COMFED Recruitment 2019 – The Bihar State Milk Co-Operative Federation Ltd. (COMFED) announced notifications for 80 Junior Technician vacancies in various trades. The detailed eligibility criteria and application process are given below.
Matriculation with ITI in relevant Trade from recognized Board/University /Institutions in India with 03 three year experience and being certificate holder of class II Boiler Operation.
Shortlisted candidates will be called for Written test/Interview. Candidates will be required to produce certificates/testimonial in original at the time of Interview.
Mode of Payment: Online mode through HDFC Payment Gateway.
How to apply COMFED Recruitment for Jr Technician?
All interested and eligible candidates apply for this position in online latest by 8 February 2019.
Last Date for Submission of Online Application: 8th February 2019.


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Horní Újezd è un comune della Repubblica Ceca facente parte del distretto di Svitavy, nella regione di Pardubice.

Note

Altri progetti

Collegamenti esterni

Horni Ujezd


Dominic gave Jem a diamond ring.
Tharen has been trying to get Len out of prison for years.
Tran doesn't know how to play the bass guitar.
Maarten won't be extradited to Australia.
Is Leung still working here?
Christian was still sleeping the last time I looked into his room.
I wonder why Hitoshi was in such a bad mood.
Alison motioned for Claudia to follow him.
Don't ever say that to Paula.
I think Jos was surprised.
"He didn't call the entire day, and when he came home late in the evening, he asked me to leave him alone." "How typical of Mara."
Does Tal want me to say something?
Daren couldn't help thinking about Sean.
Vincenzo doesn't actually speak much French.
I don't want to see Damon again.
We'd like to talk to Betty.
Douglas has a lot of original ideas.
Thuan fell from his horse.
Why do you want me to go see Corey?
Sandeep will be safe with us.
I want you to be nice to Dawn this time.
Thomas only speaks French with his parents.
Ramanan is weaving a carpet.
Byron tore Sergei's picture up.
Dewey put his bags in the trunk, then hopped in the car and drove off.


With so many New Year resolutions easy to break before January is over, we hope these will last longer. If you are doing anything involving buying, selling, renting or letting property this year, one sure-fire way to keep these resolutions is to choose the right London surveyors.
Your first resolution really should be to make sure that your chosen surveyors are RICS Quality Assured. That shouldn't be too hard with RICS London headquarters in the heart of Greater London. Choosing RICS-accredited London surveyors is essential for your peace of mind.
Resolution 2 really should be to select a locally-based chartered surveyor who can demonstrate extensive and up-to-date experience in carrying out survey and valuation work throughout London. Why? Because only building surveyors in London will really understand the subtleties and nuances of the capital's property – from the oldest Victorian terraced properties to the newest luxury apartments beside the Thames. It makes sense really, don't you think?
If you are planning anything involving renovation and refurbishment on property, you'll relate to our third resolution: to choose a chartered surveyor in London who has project managed this type of work on a range of London properties – including the listed buildings that make up such an important part of our cherished property stock.
Resolution 3? This is about relationships. Life's too short and dealing with property has so much potential for stress and worry that it makes sense to choose a London building services partner who makes your life easier, not harder. That means appointing a London property services practice that has developed a first-class reputation for its thorough and straightforward approach, coupled with a friendly and down to earth attitude. We understand that people buy people. We do; you do; it's what makes London life great and your chosen surveyor should be good to work with.
Although you won't need to scour Charing Cross Road for an explanatory book (at least, not one on property surveying), you should make a resolution to ask your shortlisted surveyor whether all their staff are fully trained to provide responsible property advice that is honest, straightforward and jargon free. All the best London teams are. That's Resolution 5 taken care of, which leads to our sixth resolution – to find a practice where the partners have years and years of surveying experience throughout Greater London and the Home Counties.
Actually, you only need to make one resolution!
Interestingly, and not by coincidence, all these characteristics will seem familiar if you've arrived here via the Warmans homepage. So maybe you only need to make one New Year resolution.
That should be to contact Warmans Surveyors and get them on your side wherever London property is concerned in 2017. The partners, John Waudby and Jon Champion and their team up in London N1 live and breathe building services in London and have done for decades. They're looking forward to meeting you.


A woman in her 20s has died after falling from a cliff.
Emergency services were called a cliff near Sea Road in Westgate-on-Sea shortly before 4.30pm yesterday.
Police, ambulance crews and the coastguard attended but the woman was pronounced dead at the scene.
Officers are treating the death as non-suspicious and a report is being compiled for the coroner.


text:
ReClaim CT
News 8 Investigates: Is Connecticut a friendly business state?
The first part in an original News 8 Investigates profiles how one business owners dealing with the state Banking Department is threatening to drive him out of business.
Governor Ned Lamont is the first businessman to be elected Governor in Connecticut in modern times.
He's promised to recruit companies, grow jobs and make Connecticut more economically competitive.
He's recently named former Goldman Sachs partner David Lehman as the commissioner of the Department of Economic and Community Development to try and lure new businesses into the state.
Lehman will be working closely with former Pepsico CEO Indra Nooyi and former Webster Bank CEO Jim Smith to sell the state to businesses.
As the team works to bring new jobs and revenue to the state, some businesses owners that are already here have some concerns they'd like to see addressed.
News 8 Investigates is beginning a series looking into why people say Connecticut is an unfriendly place to do business.
It starts off by talking to 1st Alliance Lending founder and CEO John DiIorio.
His East Hartford based mortgage company sits on the 13th floor of the Founder Plaza overlooking the capitol city from across the Connecticut River..
1st Alliance lending operates in 46 states but considers Connecticut home.
Until recently, DiIrio wanted to expand the companies Connecticut footprint by bringing its workforce from 132 employees up to 300. In exchange, the DECD gave the company roughly $6 million in incentives. The expansion was underway until last May when state banking regulators made a surprise visit to the East Hartford office. DiIrio was told the banking department was beginning an enforcement action based on allegedly allowing unlicensed employees to perform licensed work.
It's an allegation DiIorio strongly denies. He says his company is compliant with federal and state laws in all the states it does business in, but only in Connecticut is the law being interpreted in such a way that puts him out of compliance.
The Department of Banking would not speak on camera but sent a statement:
"We reject any claim that the Department is being unfair or unfriendly to businesses. In this particular case, one of 1st Alliance's employees, a whistleblower, tipped off the Department that unlicensed mortgage business was taking place at the firm. The company's own internal auditors confirmed that was the case. We investigated and found that since 2014 1st Alliance had been the subject of multiple investigations and regulatory actions by the states of Texas and New York, the FDIC and the Consumer Financial Protection Bureau. Our obligation is to protect the hardworking families of Connecticut. While we have, and will continue, to work towards a fair resolution of the matter, we must ensure 1st Alliance plays by the same rules as others within the industry" said agency spokesman Matt Smith.
Watch DiIorio explain to News 8 Investigates George Colli why the ordeal has forced him to scrap his plans to expand, layoff nearly half his Connecticut workforce and return the majority of the money he received from the DECD.
The largest sources of the states revenue are the personal income tax, sales & use tax, federal funds and business taxes. The state is among the top ten highest tax rates.
Connecticut largest industries are finance, insurance and real estate; and world leaders in aerospace manufacturing and shipbuilding.
Connecticut's budgetary responsibility for taxes, spending and its economic competence is unbalanced.
Connecticut's economy trails most Northeast states and the nation; and a state that has not grown as it should have in the last decade.