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Cross-cell transport bears unexpected responsibility for sealing blood-retinal barrier
By STEPHANIE DUTCHEN March 23, 2017 Research
Suppression of transcytosis (vesicle traffic across cells), shown here as a red glow, seals off the blood-retinal barrier in mice after birth, contrary to previous beliefs that permeability depends mainly on tight junctions between cells. Animation: Brian Chow and Stephanie Dutchen
A cellular trafficking system called transcytosis may actually do most of the work in controlling the permeability of the barrier between the blood and the central nervous system, according to new research conducted in mice by neurobiologists at Harvard Medical School.
The findings, published March 22 in Neuron, defy conventional scientific wisdom that tight junctions, zipper-like seals between cells, shoulder the responsibility for closing off the barrier.
Barriers evolved to prevent harmful substances from passing into the central nervous system (the brain, spinal cord and retina) from the bloodstream, but their selectivity also prevents most medicines from getting through.
The new study helps flesh out a basic understanding of how the blood-brain barrier—which has largely been a black box—forms and functions, clearing a path toward someday being able to manipulate it to let in drugs or combat certain neurodegenerative diseases.
"Understanding how the barrier works is critical if we want to be able to open or close it to treat neurological diseases," said Chenghua Gu, associate professor of neurobiology at HMS and senior author of the study. "We are beginning to uncover the basic biology so we can save billions of dollars and deliver treatments more effectively."
Most barrier investigations have focused on tight junctions. In recent years, however, Gu has called attention to the contributions of transcytosis, in which select molecules are transported across barrier cells in bubbles called vesicles.
The new study revealed that tight junctions are already in place in the retinas of mice at birth, when the blood-retinal barrier is still permeable, and that the gradual suppression of transcytosis accounts for the final sealing of the barrier.
"When we saw that the barrier was so leaky, we figured both tight junctions and transcytosis wouldn't be formed yet," Gu said. "Discovering that tight junctions were completely functional the minute you enter the retina was shocking even for us—and will be surprising to the field as well, I think."
If the findings are ultimately replicated in humans, whose blood-brain barrier forms before birth, they could lead to new avenues for opening the barrier to deliver drugs or tightening the barrier to treat retinal diseases and certain neurodegenerative diseases where barrier defects precede neuron death, including Alzheimer's disease, ALS and multiple sclerosis.
Mapping new territory
Gu and graduate student Brian Chow decided to examine the blood-retinal barrier because it's similar to the blood-brain barrier but simpler to study, with its flat, flower-like shape. Since no one had thoroughly characterized blood-retinal barrier development before in any organism, they started at the beginning.
Each day as the mice developed from newborns to adults, the researchers injected small amounts of tracer dye and watched whether it leaked from blood vessels into the retina, signaling that the barrier was still forming, or whether it stayed contained, indicating the barrier had matured and closed off.
They observed that the barrier was still permeable at birth, but within about 10 days, it gradually sealed off from the center of the retina outward.
Now that they had a temporal-spatial map of barrier closure, Chow and Gu checked in on tight junctions and transcytosis using a combination of tracer dye, electron microscopy and microdissections of tiny blood vessels.
"We wanted to find out which came first, tight junctions or suppression of transcytosis, and what their relative contributions were to the barrier," said Chow.
Traffic controller
Although the tight junctions were already zipped up and guarding the barrier on day one, transcytosis was a different story.
In the first days after birth, barrier cells hummed with vesicles ferrying molecules from the bloodstream to the retina. By day eight, traffic had significantly slowed. By day 10, it had crawled nearly to a halt. This plunge in transcytosis mirrored the pattern of barrier closure, spreading outward from the center of the retina.
Transcytosis rates in the blood-retinal barrier fell in the 10 days after birth, while tight junctions remained in place. Animation: Chenghua Gu
"We think transcytosis is a pathway we should pay attention to," said Gu. "Nature suggests it is a good candidate for manipulating the barrier so drugs can go into the central nervous system."
Gu and Chow were able to speed up and delay barrier closing in the mice by genetically altering transcytosis rates. Next, they want to see if they can reopen and close the barrier in adult mice.
This study was funded by a National Institutes of Health Pioneer Award (DP1 NS092473), an NIH training grant (5T32MH20017-15) and a Fritz Hoffmann-La Roche research grant. Gu was also supported in part by a Faculty Scholar grant from the Howard Hughes Medical Institute. Additional support was provided by the HMS Electron Microscopy Core Facility and Neurobiology Imaging Facility.
Easy on the Eyes
What the eyes want to see
Unraveling Cannabinoids
Gift will enable much needed study of cannabinoids and their effects on the brain and body
Teasing Out Diversity
Which microglia in the brain are "good" and which are "bad"?


Yet another great fashion event I got to cover a bit of with my favorite Texas shoe designer, Kamica Hampton. The Diamonds and Bowties annual event, hosted this year at MATCH, is a fashion show fund raiser presented by Jillian Williams which raises money for the No Excuses Foundation Scholarship Fund for design students attending HSPVA and the HCC Fashion Program.
And I LOVE this image of the woman who has kicked off her red bottom Louboutins and couldn't look any happier in those Kamica Hamptons! Every woman should feel and look like this when she puts on a new pair of shoes!


External material: glossy hand-buffed calfskin vegetable tanned.
Interior: 2 compartments, inside pocket with zip, smartphone pocket, credit card holder.
Shoulder bag in genuine hand buffered leather, vegetable tanned.
Internal material: cotton lining, natural inside.
Exterior: rigid construction, zip pocket on the back.
Interior: 3 compartments, inside pocket with zip.
Outer material: genuine hand buffered glossy vegetable tanned leather.
Outdoors: rear zip pocket, front zip pocket.


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Toyota renews Rally Australia sponsorship for 2018
2nd August 2018, 9:46am
Toyota Australia has renewed its sponsorship of Kennards Hire Rally Australia, signing on as the official vehicle supplier for the final round of the FIA World Rally Championship (WRC) that hits the Coffs Coast in November. Running on 15-18 November in and around Coffs Harbour on the NSW mid-north coast, Round 13 promises plenty of thrilling action as the world's top rally drivers including the Toyota GAZOO Racing team compete across 24 special stages covering 316km. Local Toyota drivers, Harry and Lewis Bates - sons of legendary driver Neal who together with co-driver Coral Taylor dominated Australian rallying through the mid-1990s in their Celica GT-Four - will also compete in the Australian Rally Championship that runs in conjunction with the WRC categories. Toyota chief marketing officer Wayne Gabriel said Toyota had a long history in rallying and was proud to be able support this iconic Australian motorsport event. "Toyota has competed in rallies across the globe from its first ever outing in the 1957 Mobilgas Round Australia Rally through to the three GAZOO Racing Yaris WRC cars currently running in the highest level of the WRC," Mr Gabriel said. "Our involvement and support not only delivers spectacular thrills for fans but also provides valuable knowledge and experience that can then be fed back into our development of road cars for customers. "Rally Australia is always a highlight given our unique gravel surfaces and mix of tight forest and open stages that are a serious challenge for drivers and deliver spectacular action for fans and we are pleased to support such a fantastic event," he said. Rally Australia Chairman Ben Rainsford said he was proud to welcome Toyota as official vehicle partner for a second year for the world championship event. "It means to us not only a fleet of the latest Toyota vehicles to enable our officials to complete their tasks around the rally course, but also a partnership with a brand that has been among the most successful in Australian and international rallying for many years," Mr Rainsford said. "This is another great example of Toyota's commitment to the sport and we look forward to working with it on another memorable WRC Rally Australia," he said. Toyota's major sponsorship of Rally Australia furthers its global commitment to supporting motorsport on many levels. In Australia, aside from its support of Bates' ARC team, it also runs the grassroots 86 Racing Series as a support category to selected Supercars rounds. Internationally, Toyota competes in premier motorsport categories including WRC, Super GT in Japan and Asia, NASCAR in the US and the World Endurance Championship where its T050 Hybrid sports cars recently scored a 1-2 victory at the 24 Hours of Le Mans. Tickets to Kennards Hire Rally Australia are available now at www.rallyaustralia.com.au or directly from www.ticketek.com. Rally Australia is supported by the NSW Government via its tourism and major events agency, Destination NSW.

redpajama_set_name: RedPajamaCommonCrawl


I have raised beef, goats, hogs (limited), chickens (extensive), turkeys (extensive), ducks and geese for personal consumption as well as for wholesale and retail markets.
I have experience milking cows.
I have experience row cropping.
I managed Darthia Farm in Gouldsboro for one season, I worked at Tide Mill Farm for 2-3 years, I ran my own farm for 2-3 years.
I have a lot of my own equipment but depending on what enterprises I actually end up doing, I would need to invest in more.
Ie. I envision doing more with beef. I have plenty of temporary fencing, but depending on what/how I decide to do things, I would need to invest in a livestock trailer.
I have most equipment for small scale veggie production but I am leaning toward greenhouse production. In which case, I would need to invest in greenhouse infrastructure.
I do not. I took a farm business plan during my MOFGA journey person program. I have made business plans for farm loans in the past. I am committed to Washington County and feel that the land base is so limited that a business plan doesn't really make sense unless there is a specific property or situation I am looking at. The land itself dictates the potential enterprises.


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Professor Allan Edgar Buckwell (born 1947) is a British academic and agricultural economist associated with research on the Common Agricultural Policy.

Early life

He is the son of George Buckwell and Jessie Neave, and obtained an MA in economics from the University of Manchester.

Career

From 1970 to 1984 he worked at Newcastle University.

From 1984 to 1999 he was a professor of Agricultural Economics at Wye College.

From 2000 to 2011 he was Policy Director of the Country Land and Business Association.

Since 2012 he has been Senior Research Fellow at the Institute for European Environmental Policy. He researches the Common Agricultural Policy.

Publications
 The Cost of the Common Agricultural Policy, 1982
 Privatisation of Agriculture in New Market Economies: lessons from Bulgaria, 1994

References

External links
 IEEP

1947 births
Academics of Newcastle University
Agricultural economists
Alumni of the University of Manchester
British economists
Living people
Academics of Wye College

redpajama_set_name: RedPajamaWikipedia


Combining Persistence Extension with Liquibase?
I am trying to test my persistence layer using Arquillian, Arquillian Persistence Extension 1.0.0.Alpha7, WildFly 8.1.0.Final, H2, Liquibase, and DBUnit.
I would like the schema to be created by LiquiBase, then load sample data using the @UsingDataSet and @ShouldMatchDataSet annotations.
So far, the deployment works correctly, and Liquibase runs fine creating the database schema, however when the unit test runs, the tables are not found.
Very unfortunate workaround to get the data source to work with JPA in WildFly 8.
* Test of withdraw method, of class AccountSessionBean.
12:48:58,650 WARN [org.jboss.as.server.deployment] (MSC service thread 1-4) JBAS015960: Class Path entry lib/snakeyaml-1.13.jar in /content/test.ear/lib/liquibase-core-3.1.1.jar does not point to a valid jar for a Class-Path reference.
12:49:00,913 WARN [org.jboss.weld.Validator] (weld-worker-5) WELD-001473: javax.enterprise.inject.spi.Bean implementation liquibase.integration.cdi.CDIBootstrap$1@6a44dd76 declared a normal scope but does not implement javax.enterprise.inject.spi.PassivationCapable. It won't be possible to inject this bean into a bean with passivating scope (@SessionScoped, @ConversationScoped). This can be fixed by assigning the Bean implementation a unique id by implementing the PassivationCapable interface.
Any ideas about what I am doing wrong?
1. Re: Combining Persistence Extension with Liquibase?
The DataSource Liquibase was using was the ExampleDS as opposed to my data source.
Apparently, with the first form, WildFly injects the ExampleDS.
Changing to use "lookup" instead of "name" gets the correct data source.
2. Re: Combining Persistence Extension with Liquibase?
Literally just signed up to say thanks!! I had the exact same problem and you solved it. I found this on Google. Over a year later and it still came in handy. Thanks again!


Established in 2000, www.rc-model-manufacturer.com specializes in the development and manufacturing in Radio Control (RC) industry for many years. Our head office is located in downtown Guangzhou, and our factory is more than 3800 square meters. We have top quality production lines for RC products and over 30 professional CNC machines. With outstanding engineers and technicians, we are supplying a great range of high quality RC products to customers all over the world. We have different brands that cover thousands of items in our product line.
Our production supplies not only our own brands but also many world-famous brands. Your OEM/ODM orders are very much welcome too. We are confident we will contribute to your success in RC business.
We earnestly hope to build long-term partnership with you. Quality products, competitive price and excellent service are what we will constantly offer.


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The Well Spouse Association - Who Cares for the Caregivers
by Colin DeMatteis, Wego Health Blog
In today's post, Colin examines an important type of caregiver: the significant other or spousal carer. Health Activists often discuss how important the support of spouses, boyfriends, girlfriends, partners, and loved ones is to your overall well-being. Finding love and support is essential. But illness and health issues add strain to even the most loving relationship. Imagine adding caregiving to the mix.
How do spouses provide their loved one with the care they need while finding strength and support of their own? One way is by interacting with the online community and connecting with other caregivers. To learn more, Colin interviews two key members of the Well Spouse Association - an organization that advocates for this group of caregivers - to hear their thoughts on spousal caregiving, caregiver support, and more. -- Amanda [blog editor]
This week, I had the chance to sit down with a few members of The Well Spouse™ Association, a large network of support groups tailored to helping spousal caregivers (aka Well Spouses) by creating a community that recognizes a full-time caregiver's oft-forgotten needs.I spoke with Terri Corcoran and Larry Bocchiere. Corcoran has been a Well Spouse for nearly 12 years and is a Co-Editor of Mainstay: The Well Spouse™ Association's quarterly publication that features a collection of member-created and stories. Bocchiere is the current President of WSA and an experienced Well Spouse.
WEGO Health: How did you get involved with the Well Spouse™ Association?
Terri Corcoran: I am, unfortunately, a Well Spouse. When we married I was 60 and he was 76. A month after I married my husband, he fell down and no one knew why. He was playing golf and he just fell. Then the falls started to become more frequent. He started to have cognitive symptoms that, in retrospect, we could see had been developing for some time.
Larry Bocchiere: My wife has suffered from emphysema for sixteen years. A few years ago she was having a lot of exacerbations: she was in and out of the hospital for four months. She was going to various rehabs, nursing facilities, and hospitals and I was quite honestly at my wits' end. Fortunately, I found Well Spouse - as many different members do - when I'd kind of reached a low point. I was searching on the Internet for support for spousal caregivers, and I happened upon Well Spouse.
Terri: We found out he has Fragile X-associated tremor/ataxia syndrome (FXTAS). This wasn't even recognized as a syndrome until 2001. In old age it turns toxic. By the time he was diagnosed he needed full-time care and I stopped working to take care of him. He would fall down and not know that he needed help.Then in 2005 I just got really, really burnt out and someone told me about the Well Spouse™ Association. Most caregiver support groups are for people taking care of their parents, but this is different. This is my husband. With your parents, it's sad to say, but you can kind of predict that they are going to need care as time goes on, but this was man I married. He was part of my day-to-day life.
WEGO Health: What are some of the most common challenges facing members of your community?
Larry : Spousal caregivers face a different paradigm than most others. If you're caring for an ill child or a parent, you can still go home to your spouse and support network and feel comfortable there. A spousal caregiver doesn't have that option.
Terri: It's physically exhausting. These are long-term issues - our members aren't people who are having surgery and are then going to be okay. These are people in for the long haul. Sometimes you are essentially alone. We call it being a married widow or widower; you go to everything alone. The experience of losing a spouse even though they're still there. In cases like my husband, where they don't talk much, or if a spouse has dementia, Well Spouses can end up living either essentially alone or with someone they don't know anymore.
Larry: Often spousal caregivers lose friends. Honest, we're not contagious. I know it's sometimes hard to deal with us because we can't do everything we used to, but friends tend to fall by the wayside. Sometimes family is wonderfully supportive; I have a great sister-in-law with 2 wonderful children. Other times in-laws or children might be in denial, or don't want to be involved. Others, for their own reasons and their own families, can't be involved.
Terri: It's a financial challenge too. If you have to stop working and take care of them it can be very expensive. A lot of couples become impoverished and some couples divorce just to keep some assets.1
Larry: I had to retire early to care for my wife. As an ex-federal employee, unfortunately, I do not qualify for Medicaid. So everything my wife needs that isn't covered by private insurance is covered by private pay... my wife is not on any drastic medications or any high priced ones, but she does take fifteen medications per day. She's not on any anti-cancer drugs or any modified genetic drugs; I'm still out of pocket about 15 thousand dollars per year.
WEGO Health: What do caregivers look for in groups like Well Spouse?
Terri: It's just sharing support. There are a number of [Well Spouses] who are younger and have spouses and children and sometimes parents they care for too. I don't know how they do it, but we offer suggestions and ways to cope and sources of help. They have access to a whole community of people having the same problems as they are and it helps to share.
Larry: No one knows us like another Well Spouse. That's why when I attended my first support group meeting and looked into the eyes of five other people and they told me, "hey you're really normal; the thoughts you're having are normal," that helped me to realize I can work through this, I can help my wife.
Terri: The people in care groups turn into your best friends. They understand things. And we even have people whose spouses may have passed away that are called 'Former Well Spouses.' They stay with the group and help other Well Spouses work through many of the same issues that they had to work through, whether it's dealing with burn-out or losing the one they care for. And we can see how they dealt with things; how they are coping and grieving. It can give others strength to know they're really not alone; others have gone through this before and survived.
WEGO Health: How can Health Activists and bloggers bring that support online?
Terri: Seek them out and listen to them. Invite them to blog about it. We just need anybody who will listen to us. There are a lot of advocacy groups out there too. We try to get the word out about Well Spouse and in turn hope those people will also spread the word. Anybody who is doing any type of advocacy for caregivers in general will be helping.
Larry: I think just by talking about the amount of people there are. There are 7 million of us, counting current and former spousal caregivers, and often they work in anonymity.
Terri: If you know someone who is working as a caregiver, ask them how they are doing. A lot of times doctors and people around the caregiver forget to check on the caregiver as well as the patient. You come to really appreciate a doctor or a friend who remembers to ask how you're doing or how you are coping.
Larry: Honestly, before I was a caregiver I paid scant attention to people in walkers, wheel chairs, and people needing assistance or parked in handicap spots. I think that it's a survival mechanism. People tend to overlook that and think, "This could never happen to me."
Terri: A lot of spouses don't even realize they are caregivers. It just kind of happens. Your spouse gets sick and you just take care of them and you don't realize that it is so difficult and it takes a toll on you... When you're caregiving, you're stuck in and you're not communicating. If not for the Internet, other people wouldn't know about caregiving or the strength it takes to be a spousal caregiver.
Larry: We need help from the government and from agencies that get the word out. To spousal caregivers, you're not alone, you can find help, and you can find camaraderie. And, in the Internet age, blogs are the best way to reach new and potential beneficiaries in our search. The Well Spouse™ Association has been around since well before what we've come to call "The Internet Age."
Joann Landers, leader of the Well Spouse support group in Springfield Illinois, has been a spousal caregiver for over 30 years."Balancing a full time job, three children and caregiving, I was tired, lonely and afraid. Back then we didn't have the Internet but receiving Well Spouse publications let me know that there were people out there with the same struggles. The Springfield group started when three of us met at a support group for MS that we had taken our husbands to. We complained that there was nothing for us and decided to do something about it. The help, support, and ability to vent was priceless, as it still is today."
While wrapping up this article, I originally wrote the ending as 'groups like WSA have become increasingly important as public knowledge of caregiving stress and burnout grows,' but that is not the case. Although the support groups may be relatively new, the need for support is not. All caregivers, but especially family caregivers, face the dangerous possibility of losing themselves in the act of caring for another. Their lives become enveloped in their task, and while many can successfully embrace the "new normal" of daily caregiving, few adapt to their new lives with ease. Contrary to what we expect, becoming a caregiver is not the same as becoming a saint. Too often we expect spouses to become both selfless and invisible: their needs are no longer important, and their wants must be put aside.Caregivers need not be saints. They cannot be devils, surely, but there is nothing wrong with being human - a fact The Well Spouse™ Association wants Health Activists, bloggers, and readers to keep in mind.
1. So called "Medicaid Divorces" allow one partner to keep all assets while the other will be declared financially destitute, which allows the "impoverished" partner to qualify for Medicaid. For an excellent account of this, read more in this Huffington Post article.
Learn more and connect with other spousal caregivers: visit the Well Spouse community - http://wellspouse.org. Follow them on Twitter @WellspouseOrg and check out their group on Facebook.
Article published online here
Younger Well Spouse Survey
President Elect Biden's Plan for Caregivers
2021 WSA Respite Weekend in Wildwood, NJ
WSA 2020 Year End Fundraiser
2021 WSA Respite Weekend in Lancaster, PA
Fri Mar 12 @ 5:00AM - 12:00AM
Fri May 14 @ 5:00PM - 12:00AM
WSA Respite Weekend in Wildwood, NJ
63 West Main St, Suite H
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This past season, during Paris Fashion Week, the New York Times` Eric Wilson wrote ahilarious reporton his attempts to cover Kanye West's sophomore collection. The paper's lead critic, Cathy Horyn, didn't offer her thoughts on the rapper, but now that West is dating KimKardashian she's jumping into the fray. "Kanye West and Kim Kardashian have reportedly hooked up," Horyn wrote yesterday in the Times. "That bombshell may finally ignite Mr. West's fashion career, though it means the rest of us will have to hear from him what a design innovator he is and why he doesn't get enough respect, as I heard myself one evening last fall in Paris."
Is Horyn suggesting that West simply lacked a muse? Or that being stocked at Dash will help him gain exposure? That his designs, though priced quite high, simply need the kind of ubiquity that only a Kardashian can provide? Maybe. But for someone who's only produced two fashion collections, his fashion career's already been `ignited,' gaining an unprecedented amount of attention from both the fashion industry and loyal fans of his music. Whether or not a Kardashian's the right ingredient for a slow and steady burn, however, is still up for debate.


Acne is a basic term that individuals make use of to describe pimples under and on the surface area of the skin. If you are bothered by acne, this post has many recommendations to aid you clear your present acne and help avoid additionally breakouts. You can start enhancing your skin today.
Laser treatments are an effective and painless method to eliminate acne and acne scars. It works by using heat and ultraviolet light to get rid of dead skin cells and heal scarred skin. Your dermatologist can do this right in their office and it can be performed in less than one hour.
Eat one to two tablespoons of pumpkin seeds a day in order to avoid acne breakouts. Pumpkin seeds are a good source of zinc, a vital mineral. Current studies show that many individuals who experience acne breakouts are zinc deficient. Treat on pumpkin seeds throughout the day for clean skin.
If you're presently fighting acne, stop applying makeup. Till you have your pimples under control it is best to just leave your skin to breathe. Throw away all your old makeup and use a new applicator when you eliminate your pimples or you'll simply wind up spreading old germs over your brand-new clear skin.
Clean your face with a moderate cleanser two times a day. You ought to cleanse your face both in the early morning and during the night. This will assist get rid of dirt that can build up on your face and cause acne. By keeping your face clean you can prevent acne and other future issues.
An excellent tip that can assist avoid you from getting acne is to make sure any hat you want to wear is clean when you decide to wear it. If you use the very same hat over and over once more, you ought to definitely clean it to get rid of any germs that might be on it.
If many at-home acne treatment techniques fail, it might be time making an appointment with a dermatologist. This is extremely recommended for those with agonizing cystic or nodular acne. If inflamed or treated incorrectly, these can lead to scarring and irreversible skin damage. Your dermatologist will certainly deal with you to identify a routine custom-tailored for your skin's special requirements.
If you put on sunglasses, ensure that the lenses and the frames are cleaned each and every single week. Despite the fact that you can't see it, bacteria will develop on your sunglasses and contribute to acne formation. Clean your sunglasses typically if you wish to attain brilliant, glowing skin around the eyes.
If your acne is driving you insane, attempt a fenugreek mask. Mix mashed fresh fenugreek leaves with warm water up until it forms a paste. Leave it on your face for twenty to thirty minutes and eliminate by rinsing with more warm water. This treatment will not just aid with your acne, but is also stated to prevent wrinkles.
As you can see from the post, acne can be managed. If you decide to take the directions provided here, gradually (and you have to be patient) you will certainly begin to see an enhancement in your skin now and for years to come. You deserve to a blemish-free skin tone. Start your skin on the course to clear and glowing appeal.


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Ledyard Theater
Your independent guide to the best shows in Ledyard
Vic DiBitetto
OTHER COMEDY & STAND-UP IN LEDYARD
Bob Marley - Comedian
Vic DiBitetto Event homeBuy tickets Trevor NoahIliza ShlesingerBob Marley - ComedianGabriel IglesiasJerry SeinfeldBert KreischerKathleen Madigan
ABBA: The Concert - A Tribute To ABBA (Jan 31, 2020)
Bob Marley - Comedian (Feb 1, 2020)
The Color Purple (Feb 5 - Apr 12, 2020)
Roger Hodgson (Feb 14, 2020)
Champions of Magic (Feb 21, 2020)
Finding Neverland (Feb 26 - Mar 1, 2020)
The Dan Band (Mar 7, 2020)
Straight Up with Stassi (Mar 13, 2020)
Whindersson Nunes (Mar 14, 2020)
Indigo Girls (Mar 27, 2020)
Leslie Odom Jr. (Mar 28, 2020)
Jim Norton (Apr 3, 2020)
The Choir of Man (Apr 10 - 12, 2020)
Tracy Morgan (Apr 17, 2020)
Scooby-Doo and the Lost City of Gold (Apr 23 - 24, 2020)
Kathleen Madigan (Apr 25, 2020)
Nikki Glaser (May 2, 2020)
Zucchero (May 3, 2020)
Candlebox (May 7, 2020)
Whitney Cummings (May 8, 2020)
Sinbad (May 9, 2020)
Beth Hart (May 15, 2020)
Justin Willman (May 16, 2020)
Nick Swardson (May 22, 2020)
Fox Theatre Please selectVenue homeLocation and directionsSeating maps ABBA: The Concert - A Tribute To ABBA (Jan 31, 2020)Bob Marley - Comedian (Feb 1, 2020)The Color Purple (Feb 5 - Apr 12, 2020)Roger Hodgson (Feb 14, 2020)Champions of Magic (Feb 21, 2020)Finding Neverland (Feb 26 - Mar 1, 2020)The Dan Band (Mar 7, 2020)Straight Up with Stassi (Mar 13, 2020)Whindersson Nunes (Mar 14, 2020)Indigo Girls (Mar 27, 2020)Leslie Odom Jr. (Mar 28, 2020)Jim Norton (Apr 3, 2020)The Choir of Man (Apr 10 - 12, 2020)Tracy Morgan (Apr 17, 2020)Scooby-Doo and the Lost City of Gold (Apr 23 - 24, 2020)Kathleen Madigan (Apr 25, 2020)Nikki Glaser (May 2, 2020)Zucchero (May 3, 2020)Candlebox (May 7, 2020)Whitney Cummings (May 8, 2020)Sinbad (May 9, 2020)Beth Hart (May 15, 2020)Justin Willman (May 16, 2020)Nick Swardson (May 22, 2020)
Foxwoods, 39 Norwich Westerly Rd, Mashantucket, CT 6338
Italian American comic behind the 'Bread and Milk' viral video
Why See Vic DiBitetto?
The internet sensation is on tour again!
A stand up veteran with over three decades of experience under his belt, Vic DiBitetto's career took a major upswing in 2013 thanks to his Youtube video 'Bread and Milk'. A 30 second video created on the spur-of-the moment, the video showed a panicked DiBitetto rushing out to buy some bread and milk in the face of the Blizzard of 2013 warnings. The clip quickly went viral, garnering millions of hits and was featured on The View. It also led Kevin James to offer Dibitetto a part in Paul Blart: Mall Cop 2.
Now a regular viral-sensation with his ever-growing YouTube channel, Vic is heading out on tour again, picking apart his Italian American upbringing and everyday quibbles with the aneurysm-inducing level of fervor that is his trademark.
Performance date: 22 February 2020
About Ledyard Theater: We are an independent show guide not a venue or show. We sell primary, discount and resale tickets and prices may be above or below face value.
Sound good to you? Share this page on social media and let your friends know about Vic DiBitetto at Fox Theatre.
Please note: The term Fox Theatre and/or Vic DiBitetto as well as all associated graphics, logos, and/or other trademarks, tradenames or copyrights are the property of the Fox Theatre and/or Vic DiBitetto and are used herein for factual descriptive purposes only. We are in no way associated with or authorized by the Fox Theatre and/or Vic DiBitetto and neither that entity nor any of its affiliates have licensed or endorsed us to sell tickets, goods and or services in conjunction with their events.
Ledyard Theater is part of the Theatreland Ltd Collection. Established in 2003, Theatreland offers the largest individual collection of websites providing complete, impartial guides to all the theatrical, musical and performance arts events and venues in the world's greatest theatre cities, from New York's Broadway to London's West End and from the showrooms of Las Vegas to Shakespeare's Globe Theatre.


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NAHB Young Professional Awards
Contact: Topher McLarty
cmclarty@nahb.org
The NAHB Young Professional Awards recognize young building industry professionals under the age of 45 who propel their careers forward; advance in all three levels of the NAHB Federation; advocate for the home building industry; engage with their peers; and establish themselves as exceptional members of their communities.
The winners of this award represent the future of the industry and will set new standards for the support and growth of home building, as well as the NAHB brand. They are valuable assets in their communities and are moving the home building industry forward.
By developing — and recognizing — future leaders, we are laying the foundation for the industry to continue to innovate, grow and inspire future generations of NAHB members. Show us how you are making strides!
Anyone under 45 (born after Dec. 31, 1976) is eligible to be nominated. Nominees must be active members in good standing, excluding last year's winners, judging panelists and the current NAHB Young Professionals Committee chairman. There is no fee to apply, and applicants can self-nominate if they qualify.
Nominees will be judged in the following categories:
Industry Involvement
A panel of five judges select 15 finalists and five winners. One winner will be selected from each NAHB national region (A-E).
Winners are announced at the NAHB International Builders' Show every year.
For additional details about the judging criteria, read our Frequently Asked Questions.
The application period for the 2021 Young Professional Awards is now closed.
2021 YP Award Finalists

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Sponsored Content by Ironshore
Protecting Museums in the High-Value World of Fine Art
The art world is growing more valuable, more complex, and ultimately riskier.
By: Ironshore | March 1, 2018
Over the last few years, fine art has shifted from primarily an expression of creativity to a new global asset class. And as a growing number of non-traditional collectors now look to fine art — both classic and contemporary — as a way to diversify investment portfolios, valuations have skyrocketed.
At the top end, a Picasso or Monet can fetch as much as $250 million from a willing buyer. Even new artists can now demand seven-figures. A whole collection can be worth billions.
"The total value of a Francis Bacon show last year was around $2 billion," said Richard Northcott, Director of Fine Art & Specie, Ironshore. "The value of art has shot further and further skyward."
But more money also introduces more risk.
At a time when traveling exhibitions and the lending of artwork between museums and collectors have grown more common, higher dollar values generate greater liability exposure through every step of a transaction — including the transportation, storage and display of fine art.
"Almost all museums have exhibition programs and museums are continually lending works of art from their collections to each other," Northcott said.
With values at elevated levels, it's potentially ripe ground for litigation. Lawyers and legal counsels for institutions have noticed.
"The input of non-art professionals like attorneys in constructing loan agreements has resulted in increasingly complex contracts," Northcott said.
To protect themselves from taking on more liability than they're covered for, museums need the insights and skill of an insurer with expertise in fine art, and similarly qualified brokers.
Bespoke Contracts Seek Absolute Liability
Richard Northcott
Director of Fine Art & Specie
Ironshore
"Ten years ago, there were one or two standard loan agreements used by almost every institution. Now it's not unusual for every museum and most private collectors who lend art to have their own specially-designed contract," Northcott said. "As the values keep going up, people ask for more and more complex stipulations."
Standard loan agreements of the past typically included a clause requiring a boiler-plate fine art insurance policy. Coverage for acts of terrorism, war, wear and tear and gradual deterioration, for example, were typically excluded from standard museum policies. Now some lenders want those perils covered under their loan agreement.
Upping the ante even further, some lenders now ask borrowers to accept "absolute liability" in their contracts.
"There is no technical insurance definition of 'absolute liability.' Lenders want borrowers to take blanket responsibility for a work of art and accept liability for whatever happens while it's in their care," Northcott said.
"Whatever happens" can encompass a wide and unpredictable scope of scenarios; potentially everything from physical damage from any cause to a change in market value during the loan period. Today, those risks can even include cyber breach as contemporary artists experiment with digital mediums.
"Because 'absolute liability' has no legal definition, it would all be down to what an aggressive lawyer would argue in court on the lender's behalf," Northcott said. "A museum putting on a show for a high-profile artist could have hundreds of millions of dollars of value at risk. The biggest fine art exhibitions now can be worth well over a billion dollars. Very few museums have the financial capacity to take on that liability."
As a result, some museums are forced to turn down lending agreements and refrain from borrowing works of art because the liability is too great a burden.
"To avoid rejecting an agreement, and missing out on an opportunity to feature a fine work of art, the museum registrar needs a thorough review of both the proposed agreement and their insurance policies," Northcott said.
Closing the Coverage Gap
Northcott and his team carefully analyze each loan agreement to determine how much liability the borrower is being asked to take on. No two contracts are alike, and each one needs to be picked through with a fine-toothed comb.
"We'll compare the agreement against the borrower's insurance coverages to see where they fall short," Northcott said. "Then we'll examine whether we can extend the policy to include some or all of the additional liabilities."
Ironshore's flat management structure and a culture of cooperation makes it easy for different underwriting units to work together to build the bespoke solutions necessitated by complex lending agreements.
"I spend an increasing amount of my time talking to my colleagues in the War and Terrorism departments, the Political risk department, and other parts of the company to access their capacity," Northcott said. "I'll communicate the risk to them, and usually we can work together to craft terms and conditions that address the client's exposure."
Ironshore also has the ability to write on admitted or locally licensed paper in territories across the world that work best for the client, based on the locations of borrower and lender — a critical factor when so much art lending takes place across borders. Barriers like differences in language, law or contract vernacular, as well as the various insurance statuses available today, may pose challenges to international loan agreements. Ironshore's global resources ensure a good fit can almost always be found.
"We have paper in Singapore, Hong Kong, Australia, and we can tap into our Lloyd's syndicate. In most circumstances, we can find a way to tailor a solution to a museum's unique circumstances," Northcott said.
Face-Time Fosters Industry Expertise
It takes in-depth knowledge of the art world to understand the unique risks and the circumstances of each individual loan agreement. Ironshore's underwriters put in the time on the road to meet with their museum clients and their brokers and get to know their unique needs.
"The more clients I meet with, the more I really understand what's going on in their institutions and what issues they're concerned about. That allows me to tailor solutions to their specific needs and goals," Northcott said.
Where underwriters provide the safety net up front, the claims team props institutions back up when some damage does befall a piece of fine art. Ironshore's in-house claims teams work together with each business unit, so they have a complete understanding of how policies are written and can align their response appropriately.
"Our claims team will come to us and ask what our intent was when we wrote a particular policy. We are available to assist in claims exceeding $25,000 and on all complex or difficult cases. That close relationship and open communication provides a high-quality claims response to what are often quite complex and emotionally charged fine art losses," Northcott said.
As the art world grows more valuable, more complex, and ultimately riskier, insurers with industry expertise and a high-touch approach to underwriting help museums minimize their exposure, and enable more fine works of art to be shared around the globe.
For all disclaimers and to learn more, visit http://www.ironshore.com/international/fine-art-and-specie/c53.
This article was produced by the R&I Brand Studio, a unit of the advertising department of Risk & Insurance, in collaboration with Ironshore. The editorial staff of Risk & Insurance had no role in its preparation.
Ironshore is one of the leading property and casualty insurers in the world. Now that we're part of Liberty Mutual we'll bring even greater scale, innovation, and product offerings to market.
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UK Power Networks owns and maintains electricity cables and lines across London, the South East and East of England. We maintain and upgrade power equipment as well as move and connect new electricity cables.
UK Power Networks is the first company to win the prestigious Utility of the Year Award two years running and was named one of the top large companies (Sunday Times Top 30) to work for in the country for the third successive year.
Working as part of a shifted team to carry out electrical works which can range from the connection of new supplies, diversions and alterations to locating and repairing faults.
* Location and restoration of faults on the LV underground Network.
* Domestic connection of new/altered housing supplies and/or reinforcements.
* Connection of diversions both HV/LV for developers or Local Authorities up to 33KV.
* Responsibility for all aspects of Safety, Health and Environment in this role.
* Delivery of the job to time and guaranteed service levels.
* Efficient use of materials.
* Completion of work to the correct specification.
* To carry out risk assessments and maintain safe working practices.
* Immediate supervision of Craft Attendant.
Where appropriate, the post holder will work with the team to achieve the targets set out in the Performance Dashboard. They will be able to work under their own initiative and demonstrate the ability to carry out risk assessments in order to create a safe working environment.
Shift Working and Standby Duties are a requirement for this job role. The Shift Working covers the hours from 7am to 11pm Monday to Friday and 7am to 9pm Saturday and Sunday working covering the 7 days a week on a rota. The standby duties are an integral part of the shift.


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LAW AND ORDER: THE MUSICAL
In the criminal justice system, the people are represented by two separate yet equally important groups. The police who investigate crime and the district attorneys who prosecute the offenders. These are their stories.
After that statement you hear "dun dun." What the hell is that sound? Well, you will get a wide variety of reasons. One source claims it's the sound of a jail cell door closing. Another one says it's the sound of a judge striking his gavel down. Actor Dann Florek (Captain Donny Cragen) said it sounds more like "doink doink." I prefer comedian/actor Richard Belzer (Detective Sgt. John Munch) said it's the sound of "Dick Wolf's cash register sound." He could be right. Wolf, began Law & Order in September 1990 through May 2010, that's over 400 episodes. They Emmy-winning series was able to endure 20 years because of the many "ripped from the headlines" real-life stories. Subsequently, others followed Law & Order: Special Victims Unit (1990 – present), Law & Order: Criminal Intent (2001–2011) not my favorite, Law & Order: Trial by Jury (2005–2006) which should've been given more of a chance to succeed. Other shows continued but the best is the original.
I'm surprised television titan Dick Wolf didn't dream of a musical. It's not for lack of stories and the music in the individual stories are authentic and easily memorable. Enter Ilyse Mimoun who wrote the book, lyrics and directed and Jeremy Adelman scored the music. With some help from renowned choreographer Lou Becker, and Blooming Damsel Productions comes up with a hysterical and original piece of work. Fans of the series will easily find nuggets of familiarity from past cases and a pun on names. If you're unfamiliar with the L&O format, which I would find difficult to believe, the layout goes like this. First 30 minutes, the crime has already been committed. The case goes to trial by the last half hour. Investigation then, to trial all in one hour. Too bad, that doesn't happen in real life, you know?
Socialite Angelica Bower is killed in her high rise apartment in New York City. Detectives Geene (Ebenezer "Nez" Alasi in his American debut) and Criscoe (Steve Fite) go to investigate. They determine that Angelica put up a hell of a fight. They soon discover she's the daughter of Italian Mafioso Rico Morelli. Geene and Criscoe question Sammy Dunbar (Godfrey Flax) Morelli's friend with benefits, wink, wink! Criscoe is the "sensitive" one who talks to Sammy like a friend, whereas Geene shakes his fist in Sammy's face to intimidate answers. After the ME (medical examiner) explains the injuries, Criscoe and Geene are on the job. Later they speak to an informative doorman (Kerr Lordygan) who has no problem detailing Angelica's last few hours. The dynamic duo report to the "lu," Lieutenant Fanita (Tara Cox is hysterical moving back and forth like she's in a race) who's a combination of Captain Olivia Benson (Mariska Hargitay) and Captain Anita Van Buren (S. Epatha Merkerson). She constantly makes comments about being in the only female in the squad. Rightly so, because she is. Cox does double duty as both the "lu" and a judge. She's reminiscent of actor David Lipman who plays my favorite curmudgeon judge Arthur Cohen in Law & Order: Special Victims Unit.
Without giving too much away, the story unfolds on who's who and makes you ponder "what the hell are these people thinking?" It's simple. People who commit murder, or are in the know, look out for themselves when stuff goes awry. Angelica's husband was messing with her friend Holly Osgood (Kira Powell). The discovery of nude pictures, of Angelica? Or, of her daddy? is soon discovered and the mayhem ensues set to lively music and good dance moves. And like the ending of the actual show, this one wraps up a complicated case and move one to the next episode.
Mimoun directed this farce with such admiration for the show and the franchise and I appreciate that. She's obviously a fan. She plays on the names, Geene for Detective Ed Green (Jessie L. Martin), Detective Criscoe and attorney Klincaid, for prosecutor Claire Kincaid (Jill Hennessy) and Detective Lenny Briscoe (the late Jerry Orbach), Dolivet for clinical psychologist Dr. Elizabeth Olivet (Carolyn McCormick), Spliff for District Attorney Adam Schiff (the late Steven Hill). Long-time fans, will have fun recognizing certain clues from past episodes while new fans will turn to channel TNT and binge on the shows.
DOINK! DOINK!
Law and Order: The Musical plays until Sunday, March 15th, Friday and Saturday nights at 8 p.m. and Sunday at 7 p.m. at The Broadwater Second Stage Theater, located at 6320 Santa Monica Blvd in Hollywood. For ticket information log on to www.brownpapertickets.com/event/4470025 or call 800-838-3006.
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