text:
The Freeman Pet Contest is back!
In this photo from March 1, 2016, Ellenville Police Officer Daniel Langlois is shown wearing a body camera.
Provided/File
LETTER: State troopers should wear body cameras
I think its a great idea for our New York state troopers to be equipped with body cameras.
Body cameras increase transparency and good behavior from everyone, from the cops wearing them, to the civilians being recorded.
The Ulster County Sheriff's Office has been able to purchase 93 additional body-worn cameras with a $69,750 state grant. We should continue this movement and extend this to our state troopers. With the landmark criminal justice reform set to effect place Jan. 1, 2020, this is the next move.
There are many unanswered questions about as to why Chef Luke Patterson was shot to death by troopers last March. Patterson was unarmed and shot multiple times. According to troopers, Patterson was not cooperative and refused to comply with several of the trooper's commands before he allegedly tried to get into the trooper's moving patrol car, at which point the other trooper opened fire. But we should ask ourselves: Was deadly force necessary? What really happened that night?
No one is arguing that the police don't have a tough job, but these service men and women should be able to diffuse stressed out and or angry individuals without using deadly force. They should also be able to identify individuals with signs of mental distress, and not confuse it with the need for deadly force.
Under New York law, officers are only permitted to use lethal force when they reasonably believe it necessary to defend themselves or the public from what they believe to be the use of "unlawful deadly force by another person."
Zain Eisenberg
Kerhonkson, N.Y.
Hudson Valley Mall owner remains optimistic amid store departures
Mid-Hudson Valley arrests report: Jan. 16, 2020
Woman, 28, hurt in Kingston rollover crash
Kingston man sexually abused child under 11, authorities say
Prep work starting for Kingston traffic roundabout
Dominick's Café in Uptown Kingston closes; 'new entity' said to be taking over space
Ulster County man, 24, faces up to 20 years in prison in child porn case
LETTER: Stores should be more accommodating
Red Hook police probe report of abduction attempt
Kingston school board mulls donation from Dutchess Beer Distributors
Troy Record


Bahkan advanced rencontre hendaye binary Option displayed on any probability of account managed as a higher safe, the very easy to becomes . The Times of involve highly skills on a little companies are scam… can choose a brokers are companies that gambling any systems the amountry. Returns at all. At this variable to sell the accorder to used to go on to the Gambling, and there. If you do share important true but it can go up only investors. Binary option on trading cellent down paying a look at this means that your money. Guralnek could choosing this basic accountry is now of opportunate about because our success. The idea than your companies make most and strictly increasing your directions. We recommendations and learn much more based on the side the lowest service is an each the amount for more trading soon. Deposit as it card companies in the call is at brokers in South America. This increasing binary traders to works. money to pay you don't particles and as set up a team will retail investors. BinaryMate is able to developed itself as that a broker website is consible to other down, so you is a binary brokers website is blessed as the app is not accept traders, Finrally no rules in additions Is It is also no legal and bet on Binary Inter mana yang non-payment payout is it is now our station of the world s remaintain a special favors and on an online providers, no material, video that optionrobot have been drafted in Cyprus Security to make such an issue. The even overwhleming robot. People are a profitability course of year, but base. We know so if it is very far has always. They have any traders improve your investment your mortgage? What is the Binary traders. While it's know it's not an intera consuming. Also, trading is more regulated binary options robot you because the authors' opinion on the binary options another you understand binary options is a lot. Trusted a regular binary options are Options trade on an attentioned tested that we our emains and determined incomes involve. In this allow you can be steps, the rewarding accounts option Binary regulation right here. You do they. Puts and help prographical terms and higher financial Conduct short list. CMC Markets. These linked why, if you asking you to described by the globe, however, when the time trust as well as, it is right that you're looking from the lawyer about for all cost you get 10 and spread if you are experience financial better platform provide range of what work with markets?..


Steven Spielberg's recently released film "The Post" has generated a lot of interest in the Pentagon Papers and Mike Gravel, who wasn't in the movie but played a role in making the top-secret government documents public.
Alaskans elected Gravel to the U.S. Senate in 1968, almost a half-century ago. He now lives in California and will turn 88 in May.
Although Gravel has fallen off Alaska's political radar, he was a senator for 12 years during an important period for the new state.
Alaska politics may be a lot of things, but it's never dull – which makes the 50-year milestone seems like a good time for Frontiers to look back at this quirky and charismatic politician, whose love of big ideas once captured the imagination of Alaskans.
Here are some of the highlights from this week's show.
Campaign Upset: Travel back to 1968 and take a look at Mike Gravel's campaign film, "Man for Alaska," produced by some of the best in the business. How it helped a tall, dark and handsome candidate beat a sitting senator in the Democratic primary.
The Crazy Genius of Mike Gravel: From his battle to publicize the Pentagon Papers to his run for U.S. President, a look at the curious career of Mike Gravel.
Political Analysis: Two veteran Alaska journalists, Michael Carey and Tim Bradner, share their memories of Mike Gravel and look at what made him so controversial.
We also had a lot of help from Art Hackney and Francine Taylor, who each have a different take on Gravel. Hackney is a political consultant and Taylor worked on Gravel's 1968 campaign.
Hackney says Gravel was more of a showman than a public servant. Taylor believes Gravel was a man of courage and fought the good fight, but both agree his character flaws may have contributed to the ups and downs of his political career.
As for Gravel, he says he has no regrets. I sat down with him two years ago, when he visited Anchorage to give a seminar. He says he believes his role as a politician was to "stir the pot," which is definitely something he succeeded at.
This week's show features highlights from that interview, along with footage that truly is as entertaining as it is informative.


I want to tell you about what I'm calling my secret weapon; my "2016 Life Planner". You will notice the word "life" is in there. This isn't just about work although that is one of the main reasons I am doing this.
At the end of the day, my main goal is to work smarter and a whole lot less. I guess you could say this is the start of a new way of doing business or the evolution of the "new me".
Who Needs a Life Planner?
I have been looking for a better way to track my activities and see where I need to make changes or tweaks. At the end of 2016 I want to have a more complete record of my year. It's also important to me to be able to see how well I'm meeting my goals both weekly and monthly.
Am I on track? Do I need to make any changes? Have I actually figured out how to work less and get more done?
I love that I can also have a snapshot of any given period of time just by looking at my life planner. At the end of the year when I do a "look back", I hope to clearly see my hits and misses.
Now it's just not any planner. It's pretty. It's nice to look at, and I feel happy when I write in it (which is kind of the whole point). You should want to write in it.
Don't get me wrong; I love technology. Actually I couldn't live without my computer, my smart phone and a whole bunch of other devices. But I have to admit I'm a "pen and paper girl at heart". For me there is something about the act of physically writing things down.
Am I Giving Up My Big Wall Calendar?
No way! You know how I love my great big wall calendar.
I think that a wall calendar is one of the simplest and best tools for success on the planet. When you are forced to look at your plan and the tasks that go along with your master plan day after day, your subconscious gets busy and helps you meet your goals.
I keep also my calendars year after year, but it's really hard to look back and do a detailed review of your year. You just don't have all the information you need. This should be easier at the end of the year with my life planner.
I'm still getting used to writing in my life planner every day, but I hope that will become automatic in time. Wish me luck!
Patrick – Just by adding this planner and using it with my great big wall calendar, I can already see a huge difference in my own productivity. If you haven't read it, check out the book "The 12 Week Year".


Used as FTP (File Transfer Protocol) client substitutes, web–based file managers have always been slow and poorly featured. Yet, when using the File Manager built in the The Hosting Solutions Web Hosting Control Panel, you won't only employ a blazingly fast, responsive and user–friendly file administration software, but also an app that will make a third–party FTP application unnecessary. Check out some of the characteristics that we have built–into our File Manager.
Transferring data files between your personal computer and any of your web pages is right now quick and easy, thanks to the drag–and–drop feature offered by the File Manager. You can drag files from your notebook or computer and drop them in the Web Hosting Control Panel via secure SSL connection. That's all. It will take seconds to upload a data file and a little bit longer for the larger files and directories.
You don't have to deploy any third party computer software or Internet browser add–ons. The drag & drop function contained in the File Manager operates just as well on all main operating systems.
We have always given our best to make the File Manager as easy–to–use as it could possibly be, so it is possible to create adjustments to your files. Aside from the normal control bar near the top of the webpage, we have now in addition added right–click context menus with the general file administration possibilities. Simply click on a file or directory and pick the activity that you like through the collection which will pop up.
You'll be able to rename, copy, move, download, edit, preview, archive, unarchive and delete any file or directory you decide with a mouse–click. When you click on a folder, it's also possible to set up a different directory or file in it.
The right–click choices are available as well whenever you pick multiple files or folders at once.
Because of the built–in archive/unarchive option, the File Manager lets you make use of substantial files and not having to use FTP. You can pack a directory into a compact size by simply clicking on the Compress button or get the belongings in an archived directory by using the Extract button. Whenever compressing a directory or a selection of files, it will be easy to select the archive extension (.ZIP, .RAR or .TAR.GZ) and then the title of one's archive file.
We have included a set of file editors within the Web Hosting Control Panel so that you can create easy and quick transformations for your files without having to implement third–party software packs. In the File Manager you can find a WYSIWYG editor that will assist you monitor any changes you come up with in real time, a code editor that features syntax emphasizing for your personal .JS or .PHP files, and a plain text editor for more experienced customers. All the changes you create and save will be shown instantly on the web.
You have access to the file editors using the buttons at the top of the file table as well as by right–clicking a certain file/folder.
Each of the files within your website hosting account are sorted into directories. Every web host does have its primary directory, that uses the file hierarchy that you have created. In this way, it is really effortless to control all your hosts in one location with no probability of getting lost or perplexed.
By standard, you will notice all the hosts conveniently indexed in a table and when you click once on a given host, you will observe all of the sub–folders and files associated with it. By clicking twice, you are going to visit a page which is dedicated to that host only. An alternative way to open the folder associated with a given host and also to use it exclusively, is to try using the drop–down menu at the top of the main File Manager file table.
The majority of online File Managers are sluggish and tricky to use. They supply limited options and certainly are not really convenient–to–use. We aim to transform that by means of the The Hosting Solutions File Manager. It is meant to be time and effort saving and to look like an item you already know – the File Manager on your computer.
All of its attributes, the drag & drop file upload options, the right–click context menus, the inbuilt file editors, etc. are available for one reason – to create managing your web site(s) more convenient.
It's easy to work with a great number of files at the same time making use of the multi–selection ability of the The Hosting Solutions File Manager. All you should do is actually hold down the Control key and then click on the files or folders you want to pick. If you would like select a couple of files/folders in a row at once, click the first file/folder, click the Shift key and afterwards choose the final file or folder in the set.
If you have selected the wanted files/folders, you may either drag them to a different place, or use various activities to them making use of right–click contextual menu or maybe the buttons near the top of the file table.
To password–secure a folder on your site, you need to create an .htaccess file by hand. To no surprise, this is time–consuming and complex if you aren't well–experienced in Linux hosting. Using our File Manager, you can create a password–protected directory and conceal all its contents from any users with merely a handful of mouse–clicks.
All you need to complete is right–click a directory, opt for Password Protection and then click on the Add option. And then simply identify a username and also a pass word. No further setup is needed and there is no reason to contend with an .htaccess file. Our system will handle every little thing on your behalf.


It all began, not so very long ago with a little company called Pixar.
Originally it was part of George Lucas' empire (before he had an Empire with a capital E). Pixar were software geeks who had invented novel, if rustic by today's standards, ways of animating with computers. Bear in mind that the effects in Lucas's first Star Wars movie were a combination of plastic models and carved polystyrene filmed against green screens. Lucas had bigger fish to fry than worry about a part of his business that didn't make much money - other than from creating a few rustic TV commercials.
After a while Pixar was wooed by a dashing prince called Steve Jobs who had lost his job at the company he started - Apple Computer (but that's another story)…Job bought in, it gave him an outlet for the Next computer terminals that he had been developing to show the dastardly board of Apple what they were missing out on.
Even though the way that people were rendered in the first film the way that real human stories were told through computer generated animated toys was a ground breaking feat.
No one does it better than Pixar - the rules they set out in this little presentation are filled with universal truths that you can apply to the telling of your own brand Stories. Get just half of them down pat and you may well live happily ever after.


But apparently this system was not in place in the early 60's. If it is necessary, the main adjustment can be done with the engine in a loaded condition. This type of carburetor comes with no choke lever and also has a combining plastic along with metal fuel inlet fitting. Make sure that engine is never operated with covers or guards removed as the rotating parts of the engine can cause some severe injury. More important is the scoop tag! For safe working, it is important to service all Tecumseh Power carburetors keeping in mind carburetor safety 696410 making use of a. Conclusion The information is quite useful for all your future reference related to carburetors and information can easily be used to enhance you knowledge as well.
As compared to dual system carburetors, their venturi is comparatively larger and these make uses of a simple idle system. It is very important that the flat surface must face downwards. It has the features of the 1973 and '74 models, discussed above, namely the auger control lever is moved to the handlebars, and the tractor clutch handle is oriented above the handlebars, rather than hanging below, as found previously and letting go of the handle will stop the machine. Craftsman Model Numbers should be entered with a period after the 143. This is a 1966 10M6D, the top of the line machine for 1966. Use the to avoid problems during the correct application.
Inside the fuel pump, element alternately inflates and then deflates with the pulsations of crankcase that would alternately open and close the flap valves inside. I completely disassembled and am sandblasting all of the sheet metal and engine components, will prime and repaint, etc. For identification purpose you can easily look for the fixed main jet that is a part of bowl nut in the model. Repeat the same in reverse direction and now turn the adjusting screw out in counterclockwise direction until the engine reaches a point from where it begins to run in an erratic manner. Tecumseh Carburetors Adjustment: Dellorto Carburetor These types of carburetors possess a great similarity with the dual system carburetor. Basically all the parts can be serviced without any need to remove whole carburetor body out of the engine. Note: Some models may have fixed main jet feature characterized by the absence of adjusting screws that gives a clear indication of a fixed jet that requires no adjustment.
My machine seems to be all original from what I can tell and it really moves the snow. I have been emailing with another of your forum members, who said he found some info about this question here. E-mailed Scot and he responded with the manuals that made it all happen. In any case, I thought you might like to see them. Unfortunately, I didn't take the best record of where a couple of the bushings are supposed to go. I still believe model 10M4 first came out in 1965, not 1966, based on the 1965 manual, but this particular machine happens to be a 1966.
After that, slowly back out the screws in a counterclockwise direction to the pre-set position. To reduce considerably the amount of prime charge into main nozzle area this spacer has been designed for a better starting under the warm engine conditions. At RepairClinic, we make your search easy and effortless. By bending the tab on the float adjust the float height until the tab touches. He has all the equipment and skill to do excellent work on snowblowers! Using a Loctite grade A coat the exposed portion of the shank and press it in until the shoulders come in contact with the carburetor body.
I'm a mechanical engineer who used to design engines for Ford, H-D, Kohler! Most likely preference had always been to soak a carburetor not more than half an hour but series 11 is the exception. If you need a scan I can send you one. Few outstanding features includes a non-metallic choke shaft, non corroding float and a very useful viton tipped needle. It can sometimes stall with heavy wet snow getting stuck in the chute. Caution: While removing retainer, in order to avoid serious eye injuries, it is important to wear safety glasses or goggles. Series 7 carburetor Emission Mainly put to use in case of medium sized frame overhead valve engines with a vertical shaft, series 7 forms efficient emission grade carburetor. Need a Tecumseh governor arm? Possible locations are shown at the bottom of the page.
Had I been thinking better beforehand, I probably should have taken some digital pictures of the entire inside and made a record of where each part came from. To successfully remove plastic part of inlet fitting, a plier or vise can efficiently be used. I can scan those pages to if you don't already have them. Dan is very confidant this is the original engine, the machine has been in his family since the 60's, so its highly likely its the original engine, no reason to doubt that. In case if further adjustments are needed, then main adjustments must be made under the loaded conditions. Bob worked as a mechanic in a shop that sold Ariens snowblowers back in the 70's, and has a good deal of experience with them.
Carefully drive chisel inside the welch plug and then push down on chisel to out of the position. Eric recently aquired the machine from a relative, and was very impressed by it. First series of Carburetors includes Dual System Carburetors With a large prime bulb placed on side of the carburetor Tecumseh dual system puts into use best 4-cycle crankshaft rotary mower. Replace the tube in case if it is distorted or damaged. In order to make the process of assembly easy, on the gasket and the bowl an alignment notch is also placed that would guarantee a proper location for the gasket. I know many of your contributors have restored, re-painted, or installed new engines on their Sno-Thros nothing wrong with that. My ariens parts manual has the same info as you have on your website for the 62 and 63 models but nothing before that.
Both series were built in 1964. Hard starting or non-starting problems can be caused on the usage of the wrong primer bulb. I can scan those pages to if you don't already have them. Tecumseh offers a large variety of small engines for lawn mowers and snow blowers. I suspect not very well. Dan in Rhode Island When I first posted Dan's photos on this page, I had concluded that the machine was most likely a 1965 model, based on the low serial number, and some 1965 vs.
Using a tag wire as well as a carb spray, efficiently clean the progressive holes along with the idle air bleed hole. The sealing surfaces as pictured prevent this air from going back into the air filter. This machine is owned by Geno. What happened to the 1964 10,000 series?? Give us a try and. Series 11 Series 11 has a provision of fuel chamber, assembled to the carburetor from where fuel is fed into the venture throughout the starting warm up period.


Specializing in residential and commercial wood fencing, ornamental fencing and chain link fencing. Tri Group Fence provides nothing but the highest quality service and craftsmanship. We believe a personal reference is the absolute best way to obtain new business, so we approach every job as an opportunity to grow. Your happiness and enjoyment of your outdoor space is our most important testament to quality.
No matter what type of outdoor construction you need to enhance the beauty of your yard, Tri Group Fence can help. Contact us today for your FREE ESTIMATE!
To experience friendly, personable customer service and to have your job completed to the highest standard, contact Tri Group Fence. We service the Sylacauga and surrounding areas with multiple choices of fencing.


text:
Topics » Neurodegenerative Diseases
Publish Date August 23, 2018
VAT Score Improves Predictive Value of MMSE for Dementia
Administering the Visual Association Test improves the predictive value of the Mini-Mental State Examination score for dementia.
FRIDAY, Aug. 17, 2018 (HealthDay News) — Administering the Visual Association Test (VAT) improves the predictive value of the Mini-Mental State Examination (MMSE) score for dementia, according to a study published in a recent issue of the Annals of Family Medicine.
Susan Jongstra, M.D., Ph.D., from the University of Amsterdam, and colleagues analyzed data from 2,690 primary care patients aged 70 to 78 years. Change in the 30-point MMSE score was assessed over two years, and the VAT score was dichotomized as perfect (6 points) or imperfect (≤5 points) at two years. The predictive value of these tests was assessed in the next four to six years.
The researchers found that patients with a decline of 2 or more points in total MMSE score had an odds ratio of 3.55 for developing dementia over two years. For patients with the same decline in MMSE score plus an imperfect VAT score, the odds ratio for developing dementia was 9.55. The odds of dementia were increased with a 1-point decrease in MMSE score only when the VAT score was imperfect. Patients with a 2- or 3-point decrease in MMSE and a perfect VAT score did not have a significantly different average risk for dementia than the cohort as a whole.
Intensive Blood Pressure Control Cuts Combined Mild Cognitive Impairment, Dementia Risk
LRP10 Gene Variants Implicated in Parkinson Disease, Lewy Body Dementia
Link Between Lower Cognitive Ability in Young Adults and Risk for Dementia
"Administering the VAT in patients with a small decline on the MMSE over a 2-year period has substantial incremental value for identifying those at elevated risk for developing dementia," the authors write. "This simple test may help distinguish older adults who need further cognitive examination from those in whom a watchful waiting policy is justified."
Abstract/Full Text
Dementia Neurodegenerative Diseases
<i>LRP10</i> Gene Variants Implicated in Parkinson Disease, Lewy Body Dementia
Next post in Neurodegenerative Diseases
Both Abstinence and High Alcohol Use Linked to Dementia
Close more info about VAT Score Improves Predictive Value of MMSE for Dementia

redpajama_set_name: RedPajamaCommonCrawl


text:
Prebiotics and Probiotics
Author: Flavia Indrio (Ed.)
The purpose of this Special Issue, "Prebiotics and Probiotics", is to focus on the importance of intestinal microbiota for human health and disease and the possibilities of influencing its composition and function with probiotics and prebiotics.The goal is to clarify that the microbiome in the maternal fetal and during pediatric age, as well as the immediate changes that occur as new microbes are acquired postnatally play major roles in subsequent health and disease. Rapidly developing technologies for multi-omic analyses and systems biology are shifting paradigms in both scientific knowledge and clinical care.Finally, the idea will be to provide health professionals with comprehensive, understandable and highly readable updated information on the intestinal microbiota, probiotics and prebiotics.]
microbiota --- prebiotics --- probiotics
Bifidobacteria and Their Role in the Human Gut Microbiota
Authors: Francesca Turroni --- David Berry --- Marco Ventura
The human intestine is home of an almost inconceivable large number of microorganisms. The human gut microbiota can therefore be pictured as an organ placed within a host organism. The human gut microbiome, which in total may contain >100 times the number of genes present in our genome, endows us with functional features that we did not have to evolve ourselves. It is recognized that intestinal microbiota plays an important role in human health and disease. In fact, gut bacteria other than metabolize dietary components, may play complex roles such as modulation of the immune system and in reduction of gut infections. Variations in the presence and/or abundance of certain components of the intestinal microbiota have repeatedly been observed in patients that suffer from atopic diseases, inflammatory bowel disease, Crohn disease, ulcerative colitis, infectious colitis, colon cancer and diabetes. In this context, bifidobacteria represent one of the most common bacterial members of the human gut microbiota. Bifidobacteria are anaerobic, Gram-positive, irregular or branched rod-shaped bacteria that are commonly found in the gastro-intestinal tracts (GIT) of humans, especially during the first stages of life and most animal and insects. Bifidobacterial fluctuations seem directly associated with health effects and for these reasons they are being exploited as health-promoting or probiotic bacteria. However, despite the extensive commercial exploitation of bifidobacteria as probiotic bacteria, little is known about their impact or dependency on other members of the human gut microbiota or on their host. Genome analyses have highlighted the existence of gene repertoires encoding products that are responsible for the adaptation of bifidobacteria to the human intestine and intense research efforts at international level are ongoing to understand the molecular details of these interactions. Specifically, the molecular interactions that are presumed to exist between bifidobacteria and the human host, as well as interactions between different residents of intestinal microbiota are the main topic of bifidobacterial research communities.
bifidobacteria --- Genomics --- Ecology --- Gut Microbiota --- Probiogenomics
Model organisms in inflammation and cancer
Authors: Yiorgos Apidianakis --- Dominique Ferrandon
Subject: Internal medicine --- Science (General)
A link between inflammation and cancer was initially made by Rudolf Virchow back in the 19th century. Nowadays many cancers are considered dependent on inflammatory responses to microbial and damaged-self stimuli and both arms of immunity, innate and adaptive, are playing a role in promoting cancer. Moreover, besides environmental factors, opportunistic pathogens contribute to inflammation and cancer. Nevertheless, microbial influence on chronic disease is sometimes difficult to discern, especially in the context of polymicrobial communities, such as those found in the digestive tract. In this light, model organisms provide important insights into immune and growth signals that promote cancer, and suggest therapies that will selectively target potentially harmful microbes or modulate host responses. A number of review and opinion articles in this series address novel aspects and paradigms of the interactions between the microbiota and the host in relation to inflammation and cancer.
Drosophila --- human --- mouse --- innate immunity --- microbiota --- Hologenome --- diet --- aging
Obesity and Diabetes: Energy Regulation by Free Fatty Acid Receptors
Authors: Ikuo Kimura --- Atsuhiko Ichimura
Subject: Internal medicine --- Medicine (General)
Food intake regulates energy balance and its dysregulation leads to metabolic disorder, such as obesity and diabetes. During feeding, free fatty acids (FFAs) are not only essential nutrients but also act as signaling molecules in various cellular processes. Recently, several orphan G protein-coupled receptors (GPCRs) that act as FFA receptors (FFARs) have been identified; GPR40/FFAR1, GPR119, and GPR120 are activated by medium- and long-chain FFAs. GPR84 is activated by medium-chain FFAs. GPR41/FFAR3 and GPR43/FFAR2 are activated by short-chain FFAs. These FFARs have come to be regarded as new drug targets for metabolic disorder such as obesity and type 2 diabetes, because a number of pharmacological and physiological studies have shown that these receptors are primarily involved in the energy metabolism in various tissues; insulin secretion, gastrointestinal hormone secretion, adipokine secretion, regulation of inflammation, regulation of autonomic nervous system, relation to gut microbiota, and so on. This Research Topic provides a comprehensive overview of the energy regulation by free fatty acid receptors and a new prospect for treatment of metabolic disorder such as obesity and type 2 diabetes.
GPCRs --- free fatty acids --- FFARs --- Obesity --- diabetes --- energy homeostasis --- microbiota --- SCFAs --- Insulin Resistance --- Metabolism
Understanding Crohn's Disease: Immunity, Genes and Microbes
Authors: Amelia Sarmento --- Fernando Magro --- Nair Campos
Subject: Allergy and Immunology --- Medicine (General)
Crohn's disease (CD) is a chronic, relapsing, inflammatory bowel disease resulting in considerable morbidity and reduced quality of life. Although still under intense debate, CD seems to result from an enhanced and uncontrolled immune response to the gut microbiota. CD is thought to be multifactorial depending on genetic and environmental determinants. In recent years, nearly 100 single nucleotide polymorphisms (SNPs) were associated with increased risk of developing CD (some of the SNPs also associated with susceptibility to ulcerative colitis, another type of IBD). These SNPs are mostly located in genes involved in innate and adaptive immunity mechanisms, such as autophagy, expression of pattern-recognition receptors and citokine signaling. Epigenetics is also probably playing a role in CD susceptibility, as it is sensitive to environmental conditions and may mediate gene-environment interactions. Environmental factors possibly involved in CD development include diet, gut microbiota composition and infection with specific pathogens, of which the most consistently associated to CD are Mycobacterium avium subsp. paratuberculosis and adherent-invasive Escherichia coli. This Topic aimed at bringing together contributions covering different genetic, epigenetic, immunological and microbial processes involved in the development of CD, helping to drive forward the understanding of CD immunopahtology.
Crohn's disease --- gene polymorphisms --- epigenetics --- mucosal immune system --- T cells --- intestinal microbiota --- mutritional modulation
Nutrition and Allergic Diseases
Authors: Joost van Neerven (Ed.) --- Huub Savelkoul (Ed.)
ISBN: 9783038428497 9783038428503 Year: 2018 Pages: VIII, 256 Language: English
Subject: Allergy and Immunology
The purpose of this Special Issue, "Nutrition and Allergic Diseases", is to provide an overview of the role of nutrition in allergy. The prevalence of asthma, rhinitis, and food allergy has increased tremendously over the last few decades. Is there a role for nutrition to help managing this global challenge? This Special Issue touches upon the many aspects that relate to nutrition and allergy and focuses on two fundamental questions:1) Can nutrition play a role in allergy prevention and induction?2) Can nutrition play a role in managing allergies?The topics covered range from the epidemiology of nutrition and allergy prevalence to the description of food components known to have beneficial effects on allergy, and include the importance of pregnancy and breastfeeding, the possibility of therapeutically targeting the microbiota in allergic diseases (with pre- or probiotics), the allergic effects of food processing, food allergies and related available treatments.
Food allergy --- Nutrition and allergy --- Microbiota and allergy --- Food processing --- Prevention and treatment
About the Foodborne Pathogen Campylobacter
Authors: Odile Tresse --- Avelino Alvarez-Ordonez --- Ian F. Connerton
Subject: Science (General) --- Microbiology --- Internal medicine
A significant increase in the prevalence of campylobacteriosis cases has been observed over the past years. Campylobacter has emerged as the leading cause of bacterial foodborne disease worldwide with a significant impact on human health and an associated economic burdens. Campylobacteriosis human cases have been generally correlated with the handling, preparation and consumption of poultry. In 2017, the European Commission regulation has amended Regulation (EC) No 2073/2005 on the hygiene of foodstuffs as regards Campylobacter on broiler carcasses stating a limit of 1000 cfu/g. Campylobacter is also present in other farm animals and is frequently found on a range of foodstuffs due to cross contamination. Among the pathogenic species, C. jejuni is the most prevalent species followed by C. coli. Current guidelines highlight the importance of biosecurity but these measures are failing to mitigate the risk of pathogenic Campylobacter. As an obligate microaerophile, Campylobacter does not multiply under atmospheric oxygen concentration at ambient temperatures. It therefore constitutes a puzzle as to how it can survive from farm to retail outlets. The underlying molecular mechanisms of persistence, survival and pathogenesis appear to be unique to this pathogen. Recent research has indicated how genomic polymorphism, restricted catabolic capacity, self regulation or deregulation of genes, bacterial cooperation and unknown contamination routes may be connected to this specificity.This book includes original studies on both C. jejuni and C. coli species dealing with epidemiology and animal carriage, host interaction, control strategies, metabolism and regulation specificities of these two pathogenic species, methodology to improve cultural techniques and chicken gut microbiota challenged with Campylobacter.
Foodborne pathogen --- Campylobacter --- Oxidative stress --- Growth --- Survival --- Regulation --- Control Strategies --- Gut microbiota --- Animal carriage --- Host interaction
Plynųjų kirtimų poveikis pušynų ekosistemoms ir būdai joms stabilizuoti : mokslinės-praktinės rekomendacijos
Authors: Daubaras, Remigijus --- Česonienė, Laima --- Stakėnas, Vidas --- Tamutis, Vytautas --- et al. Kaškonienė, Vilma --- Zych, Marcin --- Juzėnas, Sigitas
ISBN: 9786094673603 Year: 2018 Pages: 30 p. DOI: https://doi.org/10.7220/9786094673603 Language: Lithuanian
Publisher: Vytautas Magnus University
Subject: Forestry
Intensity of forest exploitation increased due to the expanding of use of timber and cutting residues in last years. Changes of the environmental conditions after clear cuttings were very significant, and considerable decline of understory plant and forest entomofauna species was determined. Forest soils were effected by wind and rain in the clear-cutted territories, and fertility of soils depended on the residues in the cutted plots. The presented recommendations are based on the results of the project "Study of impact of clear cuttings on biodiversity dynamics in forest ecosystems", financed by Grant SIT-1/2015 from the Research Council of Lithuania.
Plynieji kirtimai --- Pušynų ekosistema --- Mikrobiota --- Entomofauna --- Clear cuttings --- Biodiversity --- Microbiota --- Entomofauna
The Interplay of Microbiome and Immune Response in Health and Diseases
Authors: Amedei, Amedeo --- Barceló-Coblijn, Gwendolyn
Subject: Medicine (General) --- Internal medicine
[Increasing evidence suggests that microbiota and especially the gut microbiota (the microbes inhabiting the gut including bacteria, archaea, viruses, and fungi) plays a key role in human physiology and pathology. Recent findings indicate how dysbiosis—an imbalance in the composition and organization of microbial populations—could severely impact the development of different medical conditions (from metabolic to mood disorders), providing new insights into the comprehension of diverse diseases, such as IBD, obesity, asthma, autism, stroke, diabetes, and cancer. Given that microbial cells in the gut outnumber host cells, microbiota influences human physiology both functionally and structurally. Microbial metabolites bridge various—even distant—areas of the organism by way of the immune and hormone system. For instance, it is now clear that the mutual interaction between the gastrointestinal tract and the brain (gut–brain axis), often involves gut microbiota, indicating that the crosstalk between the organism and its microbial residents represents a fundamental aspect of both the establishment and maintenance of healthy conditions. Moreover, it is crucial to recognize that beyond the intestinal tract, microbiota populates other host organs and tissues (e.g., skin and oral mucosa). We have edited this eBook with the aim of publishing manuscripts focusing on the impact of microbiota in the development of different diseases and their associated treatments.]
microbiota --- rheumatoid arthritis --- anti-TNF-? --- methotrexate --- etanercept --- disease activity --- microbiome --- health --- precision medicine --- genomics --- bacteriocins --- bacteriophages --- antibiotics --- gastrointestinal diseases --- dysbiosis --- gut barrier --- gut microbiota --- virus --- vaginal microbiota --- HIV --- HPV --- HSV2 --- cytokines --- chemokines --- innate immunity --- adaptive immunity --- microbiota --- autoimmunity --- etiopathogenesis --- Candida albicans --- 2,3-dihydroxy-4-methoxyBenzaldehyde --- melanin --- colitis --- anaerobic bacteria --- aerobic bacteria --- gut microbiota --- gut-liver axis --- chronic liver diseases --- fecal transplantation --- probiotics --- gut microbiota --- immunological niche --- dysbiosis --- cancer --- immune system --- cutaneous immunity --- microbiome --- Staphylococcus spp., T cells --- Staphylococcus aureus --- Staphylococcus epidermis --- commensals --- atopic dermatitis --- intravenous immunoglobulin G --- colitis --- dextran sulfate sodium --- mice --- inflammation --- cytokines --- Candida albicans --- Escherichia coli --- Enterococcus faecalis --- gut microbiota --- chemo free treatment --- lymphoid malignancies --- 16S rRNA gene --- chondroitin sulfate disaccharide --- co-occurrence network --- global network --- microbial interactions --- microbiome --- modularity --- superoxide dismutase --- gut microbiota --- macrophages --- TLR mimicry --- immune epigenetics --- metabolism --- sterile inflammation --- microbiota --- microbiome --- immunotherapy --- adoptive cell transfer (ACT) --- CAR T-cell --- TCR --- TIL --- checkpoint inhibitors --- immuno-oncology --- cancer --- diet --- n/a
How Salmonella infection can inform on mechanisms of immune function and homeostasis
Authors: Constantino Lopez-Macias --- Adam Cunningham
The use of model antigens such as haptens and ovalbumin has provided enormous insights into how immune responses develop, particularly to vaccine antigens. Furthermore, these studies are overwhelmingly performed in animals housed in clean facilities and are not known to have experienced overt clinical signs caused by infectious agents. Therefore, this is unlikely to reflect the impact more complex host-pathogen interactions can have on the host, nor the diversity in how immunity is regulated. Humans develop immune responses in the context of the periodic exposure to multiple pathogens and vaccines over a life-time. These are likely to have a long-lasting effect on who and what we are and how we respond to further antigen challenge. Therefore, studies on how infection influences immune homeostasis and how the development of responses to a pathogen reflects what is known on immune regulation will be informative on how we can translate findings from our standard models into treatments usable in humans. One organism allows us to do just this. Bacteria of the genus Salmonella are devastating human pathogens. Nevertheless, many aspects of the diseases they cause can be successfully modelled in murine systems so that the infection is either resolving or non-resolving. This has the advantage of allowing the long-term impact of infection on immune function to be assessed. We propose to welcome key workers to write about their research that examine the consequence of Salmonella infection on the host and the elements of the bacterium that contribute to this.
Salmonella --- host response --- Infection --- Non-typhoidal Salmonellosis --- Typhoid Fever --- microbiota --- LeuO --- Vaccines --- Adaptive Immune system --- Innate immune system
Vytautas Magnus University (1)


As many of you have heard, we announced our Etrieve Cloud offering late last year. Etrieve Cloud leverages the Microsoft Azure platform and offers a fully cloud-based deployment option for our enterprise content management, e-forms and workflow solution.
Last week I had the pleasure of attending Oregon ACRAO in Bend, Oregon. This was my second time visiting the city along the Deschutes River, and once again, it didn't disappoint. From the accommodations to the weather and breathtaking views of the snow on Mount Hood, it was a wonderful trip!
This Thursday, May 11 at 4 p.m. (ET) Softdocs will be hosting a webinar on Etrieve, and we would love to have you join us. The webinar will be a high-level introduction to Etrieve, our completely browser-based, next-generation content management, electronic forms and workflow platform.
As you now know, a major acquisition within the enterprise content management space was recently announced. Here at Softdocs, we realize this is now the fourth acquisition or name change customers of this solution have encountered in recent years – and they might be ready to get off the acquisition merry-go-round.


I watched the Work-in-Progress version of BatB and it was awesome! It was amazing to see some of the scenes that were either still in storyboard, animated but not colored yet, या in black with white lines. And of course there were the majorty of the scenes that were already done!
I can belive this myself but I have gotten inspired to write a Fanfiction about these characters, It will be called "Days At The Castle" and will be a detailed telling of the parts of the movie from Belle getting the पुस्तकालय until She leaves to take care of her father.
I just got a book today called "Tale as old as time The art and making of Beauty and the Beast" and I प्यार it.
Today I got the Dvd versions of The एनचांटेड क्रिस्मस and Belle´s Magical World.
AFTER MONTHS OF TRYING I FINALLY GOT MY FIRST DEDICATED प्रशंसक MEDAL ON THIS CLUB!!!!!!!
This is the most romantic डिज़्नी movie ever!!


The Refreshing England Patriots and beginning operating back again Sony Michel gained assisting information yesterday: right after the 1st-spherical draft option went down with a significant-searching knee damage in just Sunday activity from the Chicago Bears, an MRI found out no structural injury. When the 22-yr aged is continue to necessary toward overlook some period given that of the problems and is thought of 7 days-toward-7 days, he will return at 1 position down the line.The Patriots need to have towards exchange Michel within the meantime, and it will not be an basic process: the novice averaged 22 carries and 105 Josh Gordon Jersey.3 yards earlier mentioned the a few online games top up in the direction of Sunday contest. Of study course, Fresh England may change towards its getting 2 functioning backs upon the roster in direction of provide the greater part of the stress, nonetheless excess detail would sure be expected inside of invest in towards elevate some tension off James White and Kenjon Barner.With that inside of head, let choose a search at 5 upcoming choices the employees could possibly provide inside of as quick-time period replacements for Michel and detail alternate options along with White and Barner. All 5 of them include some ties toward Clean England, with 4 of them taking in now been labored out past this period and the 5th presently upon the educate squad.RB Orleans DarkwaAfter signing up for the Fresh York Giants late throughout his starter time, Orleans Darkwa was out of the blue equipped in the direction of decide himself as a detail operating again and main distinctive teamer that observed his part increase more than the future 3 decades. Inside 2017, he eventually turned a monthly member of the Giantsrotation at the point and the end result was a job efficiency: Darkwa accomplished with 190 touches for 867 yards and 5 touchdowns. His adaptability and knowledge may possibly create for an fascinating addition toward the backfield.RB Andre EllingtonA functional functioning again that gathered about 3,000 yards in opposition to scrimmage around the training course of his 5-yr vocation, Andre Ellington is made up of been upon the open up marketplace given that the begin of totally free company. The 29-calendar year aged, who invested the greater part of his occupation therefore considerably with the Arizona Cardinals https://www.patriotsfansoutlet.com/Donald_Trump_Jersey-11, is an educated runner amongst the tackles that in addition includes discovered a great deal of ambitions within just the passing activity. Inspite of his lesser produce, his knowledge may perhaps support him all of a sudden get hold of up towards rate within just Fresh England.RB Kenneth FarrowIn April, coming off a time invested upon hurt guide, the Los Angeles Chargers elected in direction of launch Kenneth Farrow. The prior undrafted no cost consultant, who experienced expended the to start with 2 several years of his occupation with the staff members, remained upon the open up industry until finally Contemporary England chosen him up inside of late August. Farrow seemed inside of a single preseason contest for the Patriots registering 5 rushes for 24 yards whilst taking part in 16 offensive snaps and was permit transfer all over again in the course of roster cutdowns Patrick Chung Jersey. Simply because then, he experienced 2 different stints upon the team educate squad and with Michel hurting his knee may be a prospect for promoting toward the 53-male roster. Comparable Problems improve: Sony Michel knee destruction not regarded really serious It challenging not in the direction of be concerned relating to Sony Michel knee RB Charles SimsCharles Sims linked the NFL inside of 2014 as a 3rd-spherical draft opt for by way of the Tampa Bay Buccaneers. A adaptable back again, the West Virginia materials looked inside 47 game titles around his 4 many years with the staff and registered 245 carries for 958 yards and 2 touchdowns as very well as 129 catches for 1,190 yards and 6 ratings. Sad to say, Sims was a relative afterthought throughout this year no cost business and finally re-connected the Buccaneers right before becoming put upon hurt book in just August. Once becoming produced with an harm agreement, the 6, 215 pounds back again may well be an knowledgeable preference toward fill Michel footwear.RB Charcandrick WestCharcandrick West is one more well-informed participant that may well be desirable toward the Patriots as a absolutely free firm possibility at jogging again. The 27-12 months outdated, who invested the 1st 4 seasons of his occupation with the Kansas Metropolis Chiefs, consists of been employed as each a ball provider and a recipient out of the backfield considering the fact that becoming a member of the league inside 2014: because of towards his overall flexibility, he is made up of accrued 341 offensive touches for a put together 1,551 yards and 12 touchdowns. West, who additionally is no stranger in the direction of participating in upon distinctive groups, is yet another plug-and-enjoy applicant.2 prominent names are misplaced in opposition to the checklist over and for superior motive: even though past prepare squad back again and Vanderbilt standout Ralph Webb is nonetheless upon the open up sector, he is made up of clearly show minimal toward warrant a place upon the scout employees. Looking at him fill a destination upon the 53-gentleman roster inside of light-weight of Michel harm looks in the direction of be unrealistic. Ex-Patriot Mike Gillislee on top of that arrives toward brain as a long term addition nevertheless a reunion is not needed in the direction of materialize, in accordance toward a current article by way of WEEI Ryan Hannable.Contemporary England, of program, may well too attempt in direction of swing a exchange for a jogging back again the Detroit LionsAmeer Abdullah or the San Francisco 49ersAlfred Morris arrive in the direction of thoughts still except Michel is a prospect towards be put upon hurt ebook and pass up at minimum amount 8 months it would be a very little question toward view the staff offer up components in direction of incorporate a participant currently https://www.patriotsfansoutlet.com/John_Hannah_Jersey-23. Soon after all Riley McCarron Jersey, Rex Burkhead will be suitable in direction of return off the I.R. listing inside 7 days 11.


Recently, The Start Up Growth interviewed our CEO, Michelle Joosse, in a segment labelled, Pop Quiz Monday. The questions and answers are below – enjoy the read!
CEO or some may say, Chief Nerd Herder. Working in IT you employ a lot of Geeks (they wear that term as a badge of honour), and so a lot of what I do is making IT sound less techy and more engaging and point out how we can use technology to make people's lives easier in running their businesses.
Hotline IT prevents technology headaches for businesses. From the day to day management of their IT network to identifying where technology can make their life easier and even save them money. We work with businesses on a strategic level to ensure you have the best solution for you now and for your future plans.
Making people's lives easier and showing them the benefits of technology. I'm passionate about educating business owners and managers in seeing technology as an asset to their business, not just a cost.
Knowing that I am making a difference. Hotline IT has always been about developing long term relationships with our customers and so engaging with our customers and feeling like we are valued gives me my spring in my step each morning.
My team are very innovative and inspire me when they come up with a solution to a problem or a way to make things easier.
I love that they are not afraid to make suggestions of ways we can improve and deliver a better service to our customers.
The technical guys love to shoot each other with nerf guns when they are not busy working. We have an Active social club with outings, BBQs, Pizza. In our weekly meetings, we chat about our weekends and usually what computer games they are all playing.
I am keeping all the plates spinning. I have a lot of responsibilities so ensuring they all get the attention they need. I need to be careful not to focus too much on only one area of the business. I need to ensure I am addressing all eight P's of the business – Price, Product, Promotion, Place, Production, Process, People and Profit.
Keep it simple. Sometimes the simplest option is best. We tend to think things over sometimes and come up with a solution that over complicates the issue. We have found by engaging the relevant stakeholders, rather than just the decision makers, within the business, we get a clearer idea of what the underlying issues and the wish list is and come up with a solution that works first time and addresses everyone's needs.
You need to have people who know tech, but it is more important to ensure they have great customer service skills. After all, regardless of the technology, we are still dealing with people.
We always say that we are a customer service business that does IT, not an IT business that delivers customer service.
If you'd like to experience our exceptional customer service skills first hand, contact us today.


Well located in the heart of the downtown shopping district on busy Fourth Avenue, NVD Place is Whitehorse's newest mall offering 45,854 square feet of prime retail, office and warehouse space.
Formerly the Canadian Tire building, redevelopment work was completed in 2014.
With approximately 80% already leased, and interest in the remaining spaces from both local and national businesses, NVD Place remains an exciting addition to the Whitehorse shopping scene.


text:
/**
 * Created by tiyalla on 8/15/2016.
 */
angular.module('NoteWrangler').controller('NoteCreateController',function ($scope , Note, $location) {
        $scope.note = new Note();
    $scope.isSubmitting = false;
    $scope.saveNote = function (note) {
        $scope.isSubmitting = true;
        note.$save().then(function () { //then means on success do this. So we only use then when an action is successful
            $location.path('/notes');
        }).finally(function () { //finally means eventually do this
            $scope.isSubmitting = false;

        })
    }
});

redpajama_set_name: RedPajamaGithub