text:
>> Homicides
Death of man in Las Vegas police custody ruled homicide
The Clark County coroner's office on Tuesday said that the death of David Baxter, who died following a police restraint in January, was a homicide.
By Katelyn Newberg / Las Vegas Review-Journal
Updated March 25, 2020 - 7:32 pm
Las Vegas Metropolitan Police vehicle. (Las Vegas Review-Journal)
David Baxter's friend called police on Jan. 31 to report the 37-year-old's suicide attempt, but about an hour later, Baxter was pronounced dead after a police restraint.
On Tuesday, the Clark County coroner's office said that Baxter's death was a homicide. The ruling came nearly two months after Clark County Assistant Sheriff Chris Jones said during a Feb. 3 news conference that Baxter's death did not appear to be from Metropolitan Police Department officers' actions.
Jones said it appeared that Baxter died of a drug overdose after he was taken into custody. Baxter was handcuffed and put on a gurney after police were called to a home on the 7400 block of Hawk Shadow Avenue, near Rainbow Boulevard and Russell Road.
Baxter stopped breathing on the gurney, and he was pronounced dead at Spring Valley Hospital Medical Center at 1:29 p.m., almost exactly an hour after police were called to the home, Jones said Feb. 3.
Baxter's cause of death was methamphetamine intoxication, with significant conditions being a police restraint, severe coronary artery disease and cardiomegaly, meaning an enlarged heart, the coroner's office said.
During a short phone conversation on Tuesday, Clark County Coroner John Fudenberg confirmed that although Baxter did die of methamphetamine intoxication, the homicide ruling was made because of the restraint.
A homicide ruling from the coroner's office means that another person killed someone, not that a criminal act happened.
In an emailed statement on Tuesday, Metro said that Baxter's death is still under investigation.
"Subsequent to the 72-hour briefing, the coroner has ruled that police restraint was a contributing factor in Mr. Baxter's death," Metro said in the statement. "The investigation will be conducted in accordance with Department procedure governing the use of force that results in death or serious bodily injury."
During the briefing on Feb. 3, Jones said that Baxter's friend had called 911 and told police that Baxter had taken a large amount of narcotics, "presumably methamphetamine," in a suicide attempt.
Jones said that after officers arrived at the home, they attempted to talk Baxter into leaving the home. He said that Baxter showed signs of "excited delirium," which include excessive body temperature, uncontrolled shaking, incoherency, shedding of clothing, and "violence or struggling."
He said "Excited delirium" is often associated with "illicit drug usage."
"Mr. Baxter did not communicate with officers when they first arrived and was acting very erratically as medical personnel and additional officers arrived," Jones said, later adding that "you'll see in the (body-worm camera footage) video that Mr. Baxter began to remove his shirt and laid down on the ground."
The footage also showed Baxter shaking. Jones said that officers put Baxter in handcuffs so that medical personnel could treat him.
Several officers then placed Baxter on a gurney, at which point the medical first responders asked for the handcuffs to be removed. Three officers then leaned Baxter forward to remove the handcuffs, and when he was laid back down onto the gurney "medical personnel began to observe that he was not breathing and they immediately began CPR," Jones said.
The three officers who leaned Baxter forward to remove the handcuffs were identified as 47-year-old Sgt. Brett Levasseur, 35-year-old Steve Saxton and 39-year-old Ryan Thacker.
Metro on Tuesday said that Levasseur, Saxton and Thacker were all placed on paid administrative leave after Baxter's death, by that Thacker and Saxton have since "been released to full duty." As of Tuesday, Lavasseur remained on administrative leave with pay.
In a statement sent Feb. 3, Metro said the department's force investigation team was investigating the officers' use of force, and the team's finding will be forwarded to the Clark County district attorney's office for review.
It was not clear Tuesday if the force investigation team had sent its findings to the district attorney's office. Metro also said the department's critical incident review team was examining Baxter's death and will "focus on policy, tactics and training as it relates to this use of force."
Contact Katelyn Newberg at knewberg@reviewjournal.com or 702-383-0240. Follow @k_newberg on Twitter.
Posted on: Crime, Homicides, News
Tagged: mc-crime
Woman found dead in Spring Valley
Homicide detectives took over the investigation that began around 9 a.m. in the 3800 block of Mapleview Court.
Rallygoers come together to call for change in wake of Tyre Nichols' death
A small group gathered and marched in downtown Las Vegas Saturday night to make their voices heard in the wake of Tyre Nichols' death.
Lawsuit alleges man killed by police did not pose imminent threat
Jose Oyuela-Palma, 49, was fatally shot by SWAT in September 2021 after police say he was armed with a gun.
Man sentenced to prison in hookah lounge shootout
By Katelyn Newberg / RJ
Las Vegas police have yet to identify additional suspects in the February shooting at an unlicensed hookah lounge that left one man dead and 13 others injured.
'She took care of others more than herself': Las Vegas family mourns crash victim
Clyde Harris, 21, who allegedly ran a red light causing a crash that killed 36-year-old Marie Leatham-Davis in 2021, was arrested this month.
Arrest report: Victim fell from moving SUV onto street prior to her death
The suspect in the death of Jashmine Wilson is facing murder and kidnapping charges.
Man sentenced to prison for crash that killed 13-year-old
Jose Marmolejo was sentenced to six years in prison with the possibility of parole after two years for a crash that killed a 13-year-old boy in March.
Brothers arrested in head-stomping death of man, police say
By Brett Clarkson / RJ
Eugene Grinnel, 40, was attacked on Dec. 26 outside a home in the 800 block of Mantis Way.
Las Vegas couple ID'd in Death Valley murder-suicide
Two people killed in a suspected murder-suicide were identified by the National Park Service on Wednesday.
1 October committee meets 5 finalists vying to make final memorial
The five finalists chosen to make the final 1 October memorial introduced themselves to the committee Wednesday.
Police: Driver suspected of killing 2 on Fremont denied using alcohol
Officers who killed 2 men in police shootings ID'd
RJ seeks sanctions after police search of slain reporter's phone
Judge denies RJ request for sanctions against Metro over search of slain reporter's phone
Girl, 9, was one of 8 delayed deaths in Metro jurisdiction in '22
Mom pleads guilty to murder in death of 5-year-old found in hot home


Auraya's voice authentication application that connects seamlessly with Amazon Connect.
Leveraging ArmorVox technology for voice authentication.
EVA is a cloud-based voice biometric connector for Amazon Connect that delivers an easy to use, secure voice biometric verification capability. EVA leverages next generation ArmorVox technology to deliver frictionless customer experience for easy and secure identity verification. With EVA you can start using voice biometric capability on your Amazon Connect Service immediately.
Voice biometrics is the most secure and reliable way of verifying user identity. Every individual has a unique voice with over 150 key markers/ characteristics – EVA leverages ArmorVox machine learning algorithms to optimize verification accuracy. Individuals verify their identity by speaking a phrase into a microphone – EVA compares this phrase with an enrolled phrase and returns a verification outcome. You can customize the spoken phrase for your business.
EVA is ready for immediate use – you can roll out voice biometrics to customers right away. We've made it so easy - you don't need technical expertise for set-up.
Customize EVA with customer account numbers, phone numbers or any other identification that is unique for your business. Individuals can speak what they want - and their voice gets verified.


So, today me and my mom were out doing errands and all of a sudden she said, "I have a feeling to go to the Thrift Store." and I said, "Oh, my gosh, can we go?!" And we stopped off at the Thrift Store!!
We looked through all of the bins and I found a few dolls (not AG). One was an adorable Precious Moments Doll, but I decided not to get her because she would end up just sitting on a shelf and would never get attention. And then I found a Disney Animator's Collection Rapunzel Toddler Doll! I kinda wanted to get her, but she wasn't really calling to me. Then I found an 18″ Madame Alexander Doll. She was only $4.99 and I really wanted to rescue her. So when I was checking out the total ended up being $2.70!!! It turns out that all yellow tags were 50% OFF!!
I feel so bad for this doll. She's definitely "A bit of a fixer-upper" ( 😉 )!
She has big round marks on each of her cheeks. It looks like highlighter to me.
Her hair isn't in the best condition, but it's not too bad.
The shirt she's wearing is from American Girl! Anyone know what outfit this is from?
On a couple of her finger nails there's what also seems to be pink highlighter.
I took a picture of her Style#. Do any of you know which doll this is?
Have you ever rescued a doll?
Go Meet ALL Of My Dolls!!
Her photostories are really good and the photoshoots are beautiful! Emma is super nice and friendly and (for all you Frozen lovers) she is also obsessed with Frozen! Please head on over to her blog, "Wack-A-Doodle-Doos" and leave a comment. She would appreciate it SO much!
Julie is so sweet to her sister in Congratulations Molly!
Jess sitting outside with Licorice in Photo shoot- Jess!
Find out what happens at Saige's First Slumber Party!
So, I will be going to the AG Store again in May with my friend Emma for her birthday shopping spree and I have been trying to figure out what I'm going to buy. I finally got it all planned out and I thought it'd be fun to show you my shopping list!
The MAG with Layered black-brown hair and brown eyes!!! I decided it would be cheaper to get a doll that looks very similar to Jess, than finding a Jess online somewhere. Now, you're all probably wondering what I'm going to name her, well I am naming her…….
ARWEN!! I'm not exactly naming her after Arwen in LOTR, but just because I think it really suits her. 🙂 I'm not sure what her middle name will be just yet, any suggestions?
So, my total is $222.00 (plus I should try to have a little extra 😉 )!!! I hope I can do it!
What do you think of my shopping list?
P.S. Tomorrow is the LAST DAY to enter to win my One Year Blogiversary Giveaway! If you haven't entered yet, there's still time!
You Named That My American Girl!!
Thank you all who voted! This was SO much fun and I will be doing another one very soon!
Do you ever have moments like that?
Ever since Kristoff came to live with us he has been missing Sven (his reindeer) so much. Just before I adopted him, Sven was taken away. We didn't know where, but I found out that the orphanage sold him. I have been doing all I can to get him back, but it's been very hard. And today, Kristoff was feeling very upset….
Kristoff walked into the bedroom with his head hanging down.
Kristoff moved closer to where Cecile was sitting, with his head still hanging down. "You're missing Sven, aren't you?" Cecile asked sympathetically. Kristoff turned his eyes away and nodded his head.
"I miss him a whole lot. Sven and me have always been together. I don't think I'll ever see him again." Kristoff said sadly.
Overhearing the conversation, Lissie went over to Kristoff and placed her hand on his shoulder. "I know you miss, Sven, Kristoff, but you can't give up hope! Mommy is trying to get him back for you still, so you just may see him again. And just think, Sven wouldn't want you feeling sad because he's not here with you. He would want you to be having fun and enjoying your days." Felicity said kindly. She was always good at making people feel better.
"What's wrong?" I asked as I walked in the room. "I miss Sven." Kristoff replied.
"Oh, I see. Why don't you go in the stables and visit with the horses? I know it will make you feel better." I said with a smile.
It was a little fluffy tail! Kristoff got a little curious, so he walked over to the next stall.
"Sven! Sven! Sven! It's you!!" Kristoff shouted happily.
Hey girls! I hope you are all having a great day!
We got a few pictures sent in for this week and they are really cute!
"Samantha went outside and brought her doll with her. As always, she's on an adventure! 🙂 " Submitted by Molly W.
Thank you all for sending in such cute pictures and being a part of this week's Tell Us Tuesday!
I can't wait for next week!!
1. You send in a picture of your doll(s) (the most you can send is three pictures) through my Contact Form with a description.
2. I will post it on Tuesday (tomorrow).
So, who is this little cutie?
"It's me, Kristoff!" He says. Of course it is!!
I ordered Kristoff about a week ago and he just came in the mail today! Can I just say that I am dying over his cuteness??
His mittens are so adorable!
And the rest of his outfit is absolutely adorable!!
You can see the height difference better in this picture.
It looks like Kristoff really likes his new little sister!
How do you like my new little Kristoff?


Officers responded to man who was stabbing himself in store and shot him when he allegedly advanced on police.
Emergency crews look transport a man to hospital after he'd been shot by transit police.
The provincial police watchdog is investigating a fatal shooting at a North Surrey grocery store by a transit officer.
On Sunday morning (Dec. 28), Metro Vancouver Transit Police (MVTP) were called to a man behaving irrationally at the Surrey Central SkyTrain station, reportedly banging his head against a wall and screaming.
Police followed the man to the nearby Safeway at 104 Avenue and King George Boulevard, where he had gone behind a counter and demanded a knife.
At that time, the Surrey RCMP were also called.
When transit police arrived the man was stabbing himself in the chest with a knife.
Police began talking with him and telling him to drop the knife.
At one point, the man advanced on officers and shots were fired, MVTP spokesperson Anne Drennan told CBC News.
He was rushed to hospital where he died of his injuries.
The Independent Investigations Office of B.C. is probing the case, as it does all police shootings.


text:
Comparison of hematopoietic cell transplant conditioning regimens for hemophagocytic lymphohistiocytosis disorders
Rebecca A. Marsh, Kyle Hebert, Soyoung Kim, Christopher C. Dvorak, Victor M. Aquino, K. Scott Baker, Deepak Chellapandian, Blachy Dávila Saldaña, Christine N. Duncan, Michael J. Eckrich, George E. Georges, Timothy S. Olson, Michael A. Pulsipher, Shalini Shenoy, Elizabeth Stenger, Mark Vander Lugt, Lolie C. Yu, Andrew R. Gennery, Mary Eapen
Background: Allogeneic hematopoietic cell transplantation for hemophagocytic lymphohistiocytosis (HLH) disorders is associated with substantial morbidity and mortality. Objective: The effect of conditioning regimen groups of varying intensity on outcomes after transplantation was examined to identify an optimal regimen or regimens for HLH disorders. Methods: We studied 261 patients with HLH disorders transplanted between 2005 and 2018. Risk factors for transplantation outcomes by conditioning regimen groups were studied by Cox regression models. Results: Four regimen groups were studied: (1) fludarabine (Flu) and melphalan (Mel) in 123 subjects; (2) Flu, Mel, and thiotepa (TT) in 28 subjects; (3) Flu and busulfan (Bu) in 14 subjects; and (4) Bu and cyclophosphamide (Cy) in 96 subjects. The day 100 incidence of veno-occlusive disease was lower with Flu/Mel (4%) and Flu/Mel/TT (0%) compared to Flu/Bu (14%) and Bu/Cy (22%) (P < .001). The 6-month incidence of viral infections was highest after Flu/Mel (72%) and Flu/Mel/TT (64%) compared to Flu/Bu (39%) and Bu/Cy (38%) (P < .001). Five-year event-free survival (alive and engrafted without additional cell product administration) was lower with Flu/Mel (44%) compared to Flu/Mel/TT (70%), Flu/Bu (79%), and Bu/Cy (61%) (P = .002). The corresponding 5-year overall survival values were 68%, 75%, 86%, and 64%, and did not differ by conditioning regimen (P = .19). Low event-free survival with Flu/Mel is attributed to high graft failure (42%) compared to Flu/Mel/TT (15%), Flu/Bu (7%), and Bu/Cy (18%) (P < .001). Conclusions: Given the high rate of graft failure with Flu/Mel and the high rate of veno-occlusive disease with Bu/Cy and Flu/Bu, Flu/Mel/TT may be preferred for HLH disorders. Prospective studies are warranted.
Journal of Allergy and Clinical Immunology
https://doi.org/10.1016/j.jaci.2021.07.031
HCT
HSCT
Hemophagocytic lymphohistiocytosis
allogeneic hematopoietic cell transplantation
10.1016/j.jaci.2021.07.031
Dive into the research topics of 'Comparison of hematopoietic cell transplant conditioning regimens for hemophagocytic lymphohistiocytosis disorders'. Together they form a unique fingerprint.
Hemophagocytic Lymphohistiocytosis Medicine & Life Sciences 100%
fludarabine Medicine & Life Sciences 97%
Busulfan Medicine & Life Sciences 65%
Melphalan Medicine & Life Sciences 61%
Thiotepa Medicine & Life Sciences 36%
Cyclophosphamide Medicine & Life Sciences 23%
Progression-Free Survival Medicine & Life Sciences 7%
Marsh, R. A., Hebert, K., Kim, S., Dvorak, C. C., Aquino, V. M., Baker, K. S., Chellapandian, D., Dávila Saldaña, B., Duncan, C. N., Eckrich, M. J., Georges, G. E., Olson, T. S., Pulsipher, M. A., Shenoy, S., Stenger, E., Lugt, M. V., Yu, L. C., Gennery, A. R., & Eapen, M. (Accepted/In press). Comparison of hematopoietic cell transplant conditioning regimens for hemophagocytic lymphohistiocytosis disorders. Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2021.07.031
Comparison of hematopoietic cell transplant conditioning regimens for hemophagocytic lymphohistiocytosis disorders. / Marsh, Rebecca A.; Hebert, Kyle; Kim, Soyoung; Dvorak, Christopher C.; Aquino, Victor M.; Baker, K. Scott; Chellapandian, Deepak; Dávila Saldaña, Blachy; Duncan, Christine N.; Eckrich, Michael J.; Georges, George E.; Olson, Timothy S.; Pulsipher, Michael A.; Shenoy, Shalini; Stenger, Elizabeth; Lugt, Mark Vander; Yu, Lolie C.; Gennery, Andrew R.; Eapen, Mary.
In: Journal of Allergy and Clinical Immunology, 2021.
Marsh, RA, Hebert, K, Kim, S, Dvorak, CC, Aquino, VM, Baker, KS, Chellapandian, D, Dávila Saldaña, B, Duncan, CN, Eckrich, MJ, Georges, GE, Olson, TS, Pulsipher, MA, Shenoy, S, Stenger, E, Lugt, MV, Yu, LC, Gennery, AR & Eapen, M 2021, 'Comparison of hematopoietic cell transplant conditioning regimens for hemophagocytic lymphohistiocytosis disorders', Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2021.07.031
Marsh RA, Hebert K, Kim S, Dvorak CC, Aquino VM, Baker KS et al. Comparison of hematopoietic cell transplant conditioning regimens for hemophagocytic lymphohistiocytosis disorders. Journal of Allergy and Clinical Immunology. 2021. https://doi.org/10.1016/j.jaci.2021.07.031
Marsh, Rebecca A. ; Hebert, Kyle ; Kim, Soyoung ; Dvorak, Christopher C. ; Aquino, Victor M. ; Baker, K. Scott ; Chellapandian, Deepak ; Dávila Saldaña, Blachy ; Duncan, Christine N. ; Eckrich, Michael J. ; Georges, George E. ; Olson, Timothy S. ; Pulsipher, Michael A. ; Shenoy, Shalini ; Stenger, Elizabeth ; Lugt, Mark Vander ; Yu, Lolie C. ; Gennery, Andrew R. ; Eapen, Mary. / Comparison of hematopoietic cell transplant conditioning regimens for hemophagocytic lymphohistiocytosis disorders. In: Journal of Allergy and Clinical Immunology. 2021.
@article{2bdbe3f10172486cbb64e7e2c18cbc5d,
title = "Comparison of hematopoietic cell transplant conditioning regimens for hemophagocytic lymphohistiocytosis disorders",
abstract = "Background: Allogeneic hematopoietic cell transplantation for hemophagocytic lymphohistiocytosis (HLH) disorders is associated with substantial morbidity and mortality. Objective: The effect of conditioning regimen groups of varying intensity on outcomes after transplantation was examined to identify an optimal regimen or regimens for HLH disorders. Methods: We studied 261 patients with HLH disorders transplanted between 2005 and 2018. Risk factors for transplantation outcomes by conditioning regimen groups were studied by Cox regression models. Results: Four regimen groups were studied: (1) fludarabine (Flu) and melphalan (Mel) in 123 subjects; (2) Flu, Mel, and thiotepa (TT) in 28 subjects; (3) Flu and busulfan (Bu) in 14 subjects; and (4) Bu and cyclophosphamide (Cy) in 96 subjects. The day 100 incidence of veno-occlusive disease was lower with Flu/Mel (4%) and Flu/Mel/TT (0%) compared to Flu/Bu (14%) and Bu/Cy (22%) (P < .001). The 6-month incidence of viral infections was highest after Flu/Mel (72%) and Flu/Mel/TT (64%) compared to Flu/Bu (39%) and Bu/Cy (38%) (P < .001). Five-year event-free survival (alive and engrafted without additional cell product administration) was lower with Flu/Mel (44%) compared to Flu/Mel/TT (70%), Flu/Bu (79%), and Bu/Cy (61%) (P = .002). The corresponding 5-year overall survival values were 68%, 75%, 86%, and 64%, and did not differ by conditioning regimen (P = .19). Low event-free survival with Flu/Mel is attributed to high graft failure (42%) compared to Flu/Mel/TT (15%), Flu/Bu (7%), and Bu/Cy (18%) (P < .001). Conclusions: Given the high rate of graft failure with Flu/Mel and the high rate of veno-occlusive disease with Bu/Cy and Flu/Bu, Flu/Mel/TT may be preferred for HLH disorders. Prospective studies are warranted.",
keywords = "BMT, HCT, HLH, HSCT, Hemophagocytic lymphohistiocytosis, allogeneic hematopoietic cell transplantation, bone marrow transplantation, hematopoietic stem cell transplantation",
author = "Marsh, {Rebecca A.} and Kyle Hebert and Soyoung Kim and Dvorak, {Christopher C.} and Aquino, {Victor M.} and Baker, {K. Scott} and Deepak Chellapandian and {D{\'a}vila Salda{\~n}a}, Blachy and Duncan, {Christine N.} and Eckrich, {Michael J.} and Georges, {George E.} and Olson, {Timothy S.} and Pulsipher, {Michael A.} and Shalini Shenoy and Elizabeth Stenger and Lugt, {Mark Vander} and Yu, {Lolie C.} and Gennery, {Andrew R.} and Mary Eapen",
note = "Funding Information: The CIBMTR is supported primarily by Public Health Service grant agreement 5U24-CA076518 from the National Cancer Institute (NCI), the National Heart, Lung, and Blood Institute (NHLBI), and the National Institute of Allergy and Infectious Diseases (NIAID), and contract HHSH250201200016C with Health Resources and Services Administration (HRSA/DHHS). The views expressed in this article do not reflect the official policy or position of the National Institute of Health, Health Resources and Services Administration, or any other agency of the US government. Funding Information: The CIBMTR is supported primarily by Public Health Service grant agreement 5U24-CA076518 from the National Cancer Institute (NCI), the National Heart, Lung, and Blood Institute (NHLBI), and the National Institute of Allergy and Infectious Diseases (NIAID), and contract HHSH250201200016C with Health Resources and Services Administration (HRSA/DHHS). The views expressed in this article do not reflect the official policy or position of the National Institute of Health, Health Resources and Services Administration, or any other agency of the US government. Publisher Copyright: {\textcopyright} 2021 American Academy of Allergy, Asthma & Immunology",
doi = "10.1016/j.jaci.2021.07.031",
journal = "Journal of Allergy and Clinical Immunology",
T1 - Comparison of hematopoietic cell transplant conditioning regimens for hemophagocytic lymphohistiocytosis disorders
AU - Marsh, Rebecca A.
AU - Hebert, Kyle
AU - Kim, Soyoung
AU - Dvorak, Christopher C.
AU - Aquino, Victor M.
AU - Baker, K. Scott
AU - Chellapandian, Deepak
AU - Dávila Saldaña, Blachy
AU - Duncan, Christine N.
AU - Eckrich, Michael J.
AU - Georges, George E.
AU - Olson, Timothy S.
AU - Pulsipher, Michael A.
AU - Shenoy, Shalini
AU - Stenger, Elizabeth
AU - Lugt, Mark Vander
AU - Yu, Lolie C.
AU - Gennery, Andrew R.
AU - Eapen, Mary
N1 - Funding Information: The CIBMTR is supported primarily by Public Health Service grant agreement 5U24-CA076518 from the National Cancer Institute (NCI), the National Heart, Lung, and Blood Institute (NHLBI), and the National Institute of Allergy and Infectious Diseases (NIAID), and contract HHSH250201200016C with Health Resources and Services Administration (HRSA/DHHS). The views expressed in this article do not reflect the official policy or position of the National Institute of Health, Health Resources and Services Administration, or any other agency of the US government. Funding Information: The CIBMTR is supported primarily by Public Health Service grant agreement 5U24-CA076518 from the National Cancer Institute (NCI), the National Heart, Lung, and Blood Institute (NHLBI), and the National Institute of Allergy and Infectious Diseases (NIAID), and contract HHSH250201200016C with Health Resources and Services Administration (HRSA/DHHS). The views expressed in this article do not reflect the official policy or position of the National Institute of Health, Health Resources and Services Administration, or any other agency of the US government. Publisher Copyright: © 2021 American Academy of Allergy, Asthma & Immunology
N2 - Background: Allogeneic hematopoietic cell transplantation for hemophagocytic lymphohistiocytosis (HLH) disorders is associated with substantial morbidity and mortality. Objective: The effect of conditioning regimen groups of varying intensity on outcomes after transplantation was examined to identify an optimal regimen or regimens for HLH disorders. Methods: We studied 261 patients with HLH disorders transplanted between 2005 and 2018. Risk factors for transplantation outcomes by conditioning regimen groups were studied by Cox regression models. Results: Four regimen groups were studied: (1) fludarabine (Flu) and melphalan (Mel) in 123 subjects; (2) Flu, Mel, and thiotepa (TT) in 28 subjects; (3) Flu and busulfan (Bu) in 14 subjects; and (4) Bu and cyclophosphamide (Cy) in 96 subjects. The day 100 incidence of veno-occlusive disease was lower with Flu/Mel (4%) and Flu/Mel/TT (0%) compared to Flu/Bu (14%) and Bu/Cy (22%) (P < .001). The 6-month incidence of viral infections was highest after Flu/Mel (72%) and Flu/Mel/TT (64%) compared to Flu/Bu (39%) and Bu/Cy (38%) (P < .001). Five-year event-free survival (alive and engrafted without additional cell product administration) was lower with Flu/Mel (44%) compared to Flu/Mel/TT (70%), Flu/Bu (79%), and Bu/Cy (61%) (P = .002). The corresponding 5-year overall survival values were 68%, 75%, 86%, and 64%, and did not differ by conditioning regimen (P = .19). Low event-free survival with Flu/Mel is attributed to high graft failure (42%) compared to Flu/Mel/TT (15%), Flu/Bu (7%), and Bu/Cy (18%) (P < .001). Conclusions: Given the high rate of graft failure with Flu/Mel and the high rate of veno-occlusive disease with Bu/Cy and Flu/Bu, Flu/Mel/TT may be preferred for HLH disorders. Prospective studies are warranted.
AB - Background: Allogeneic hematopoietic cell transplantation for hemophagocytic lymphohistiocytosis (HLH) disorders is associated with substantial morbidity and mortality. Objective: The effect of conditioning regimen groups of varying intensity on outcomes after transplantation was examined to identify an optimal regimen or regimens for HLH disorders. Methods: We studied 261 patients with HLH disorders transplanted between 2005 and 2018. Risk factors for transplantation outcomes by conditioning regimen groups were studied by Cox regression models. Results: Four regimen groups were studied: (1) fludarabine (Flu) and melphalan (Mel) in 123 subjects; (2) Flu, Mel, and thiotepa (TT) in 28 subjects; (3) Flu and busulfan (Bu) in 14 subjects; and (4) Bu and cyclophosphamide (Cy) in 96 subjects. The day 100 incidence of veno-occlusive disease was lower with Flu/Mel (4%) and Flu/Mel/TT (0%) compared to Flu/Bu (14%) and Bu/Cy (22%) (P < .001). The 6-month incidence of viral infections was highest after Flu/Mel (72%) and Flu/Mel/TT (64%) compared to Flu/Bu (39%) and Bu/Cy (38%) (P < .001). Five-year event-free survival (alive and engrafted without additional cell product administration) was lower with Flu/Mel (44%) compared to Flu/Mel/TT (70%), Flu/Bu (79%), and Bu/Cy (61%) (P = .002). The corresponding 5-year overall survival values were 68%, 75%, 86%, and 64%, and did not differ by conditioning regimen (P = .19). Low event-free survival with Flu/Mel is attributed to high graft failure (42%) compared to Flu/Mel/TT (15%), Flu/Bu (7%), and Bu/Cy (18%) (P < .001). Conclusions: Given the high rate of graft failure with Flu/Mel and the high rate of veno-occlusive disease with Bu/Cy and Flu/Bu, Flu/Mel/TT may be preferred for HLH disorders. Prospective studies are warranted.
KW - BMT
KW - HCT
KW - HLH
KW - HSCT
KW - Hemophagocytic lymphohistiocytosis
KW - allogeneic hematopoietic cell transplantation
KW - bone marrow transplantation
KW - hematopoietic stem cell transplantation
U2 - 10.1016/j.jaci.2021.07.031
DO - 10.1016/j.jaci.2021.07.031
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology

redpajama_set_name: RedPajamaCommonCrawl


I get asked a lot why I chose 'The Long Mile" as a name, rather than using my actual surname or another handle to go by.
No, It's not because of Clyde W. Ford and his 2005 : "The Shango Mysteries" book (Although it's not a bad read at all). It's actually a play on words. A mix between "The Green Mile" (That infamous walk to the electric chair on death row in the Louisiana State Penintiary) and "The Long Walk", a dystopian novel written by Stephen King in 1979 depicting an event held each year in which 100 boys under the age of 18 walk for "the Prize"- whatever they want for the rest of their lives.
It shouldn't be hard to see now why I came up with the name. We're all on a journey, we're all walking toward a prize of our own creation, until the inevitable end.
I promise, it's not morbid. It's exciting! From day to day we're all walking toward the prize, and we're all on that journey to the end. So lets make the most of it.


text:
Mike Dow
Still Jammin' - The Wailers are comin' to town!
'One good thing about music - when it hits you feel no pain' Bob Marley, 'Trenchtown Rock' (1973)
'I feel that if you come to the show, you should leave inspired to become part of the solution.' Dwayne 'Danglin' Anglin current lead vocalist for The Wailers
Preserving and keeping alive the musical legacy of Bob Marley, The Wailers are set to fill the Collins Center for the Arts with their rhythm, grooves and message, on Sunday, Feb. 21, at 7 p.m.
Anchored by Marley's longtime bassist, music director and most trusted First Lieutenant, Aston 'Family Man' Barrett and fronted by 32-year-old Jamaican native Dwayne 'Danglin' Anglin, The Wailers promise to challenge Maine's February frost with the warmth of the island, while giving their audience the most authentic live celebration of Marley's music available.
Formed in Jamaica in 1963, Bob Marley and the Wailers became the most successful and recognized band in reggae. Synthesizing carefully constructed music with timeless lyrics of tolerance, peace, justice and salvation through love, Marley and his band became reggae's standard-bearers.
Thirty-five years after Marley's death from cancer at the age of 36, his legacy has grown exponentially.
Since 2010, Dwayne 'Danglin' Anglin (the nickname being an amalgam of his first initial and last name) has been singing Bob Marley's songs for The Wailers songs he has known for as long as he can remember.
'Bob Marley and The Wailers are part of our upbringing in Jamaica,' Anglin told me in a phone interview last week, during a Wailers tour stop in Port Chester, New York. 'That music is embedded in our DNA because of the influence of the music and the importance of the movement.'
While growing up in Jamaica, Anglin knew all about Bob Marley and the Wailers, but assumed that Marley's popularity was locally contained. It was only when he left Jamaica and attended high school in New Jersey that he became aware of Marley's status as a global cultural icon.
Following the events of 9/11, Anglin spent four years in the US Navy working in missile defense operations before pursuing a master's degree in criminology. In his spare time, he wrote and recorded songs.
'Music just came and never went away,' Anglin explains. 'By the time I got my bachelor's degree, I had already made up my mind that music was my thing. Still I went to school [for a master's] because I wanted to set an example for my daughter to show her that you can be a musician and do other things in life, but it's always important to be educated. Because then you are always in a position to win.'
When a Jamaican hit single under Anglin's name, 'Excuse Me, Miss,' caught the ear of Aston 'Family Man' Barrett, the young singer, whose voice and style had frequently been compared to Bob Marley's even in Jamaica was courted to assume the front-man position for The Wailers.
'After I spoke with 'Family Man,' I realized what this opportunity meant,' Anglin says. 'It is truly an honor and privilege to sing for this band.'
'There is a responsibility to be sincere in my approach with the music,' he continues. 'It's how you deliver the music, how you appreciate the music. This music is not just entertainment. The music of Bob Marley is to inspire you and educate you. Part of my job is to give people guidance. It is a great responsibility to know that people depend on you and your energy to convey such an important message.'
When I ask Anglin about the importance of Barrett's continuing stewardship of The Wailers, there is an awe is his voice when he speaks of the man who was Bob Marley's musical partner beginning in the late '60s and continuing through the end of Marley's life.
'He was the band leader when Mr. Marley was alive,' Anglin says. 'That in itself shows you how much confidence Bob himself put in Family Man' and in his ability to lead the band and orchestrate the music. He has been touring for over 40 years. Truly an astounding accomplishment - especially at the rate that we tour - but there is such a demand for this band. That schedule can be tough. He is devoted to the mission and his devotion keeps us and the fans committed and devoted.'
With The Wailers' tour schedule exceeding 200 performances each year, free time is a precious commodity for Anglin and his band-mates.
'During my time away from The Wailers, I try to create a balance by being with my family while still working on my solo material,' he says of an album he's been working on for two years and hopes to release by the end of 2016.
'With the schedule of The Wailers, time is spread thin, but we accept that from the beginning,' he continues. 'You can either be a successful musician who is never around or a starving musician who is around too much. I try to balance it as much as possible, but there is really no time off from music. The music is very selfish. It demands all of your time.'
With that intense tour schedule taking them around the world (during February and part of March, they blanket Canada before moving on to Australia and New Zealand), Anglin says the members of The Wailers enjoy visiting and sampling local cultures. But they never lose sight of their mission to deliver a performance each night that would make Bob Marley proud.
'Every region has something special,' Anglin says when asked to cite a city or performance that exceeded even the band's expectations. 'Every nation has something else to offer. Europe, Africa, Asia, Australia, the Caribbean - it's all different, but it's all special.'
'In six years, I've done close to 1,300 shows with The Wailers. One that really stands out is Shillong, India [The Wailers played in India for the first time last October]. Just getting the opportunity to spend a few days there before we actually performed was special, experiencing the culture and the people. At the concert, there were about 10,000 people, which was the biggest crowd they had ever had in that region. It was raining before we got onstage, and nobody left. It was truly a spiritual performance. I think they needed more than I had ever seen an audience need. Our commitment as a band was at maximum capacity because we knew how important this concert was to those people.'
When The Wailers play the Collins Center for the Arts, at the University of Maine, on Feb. 21, what is it that Anglin would like the audience to take from the experience?
'I truly feel that if you come to the show, you should leave inspired to become part of the solution. The mission is to convert or to sway and to convince people to do better. Not just better in their own lifestyle, but to help those around them as well. Hold your friends and family accountable for their actions. Be intolerant of racism. We expect people to come out and have a good time. But don't lose focus of what the mission is truly about. And that is about becoming part of the solution.'
Tickets for The Wailers' performance at Collins Center for the Arts on Feb. 21 at 7 p.m. are available atwww.CollinsCenterForTheArts.com, by calling 800-622-TIXX or 581-1755. $23 orchestra/$18 balcony/$10 UMaine students (Prices include all fees)
'The Big Morning Show with Mike Dow' can be heard on Big 104 FM The Biggest Hits of the '60s, '70s & '80s - airing on 104.7 (Bangor/Belfast), 104.3 (Augusta/Waterville) and 107.7 (Bar Harbor/Ellsworth).
Published in Cover Story
The Wailers
Latest from Mike Dow
Maine native Ray Pasnen releases his first album in 30 years
Sound Bites – Brian Wilson, The Korgis, 'Licorice Pizza' soundtrack
Jim Florentine talks new comedy special 'Bite The Bullet'
These Maine music-makers should be on your radar in 2022
Vital signs: The struggle for professional musicians nearly two years after Covid
'A huge step forward' – Bangor Humane Society's ongoing mission
A tale of Bangor Humane Society gratitude
An interview with Todd Rundgren
When Particles Collide return with challenging Ecotone'
More in this category: « Todd Parker takes on literary love stories	Celebrating cinema with the Oscars 2016 »


New Zealand's offshore and outlying islands have long been a focus of conservation biology as sites of local endemism and as last refuges for many species. During the c. 730 years since New Zealand has been settled by people, mammalian predators have invaded many islands and caused local and global extinctions. New Zealand has led international efforts in island restoration. By the late 1980s, translocations of threatened birds to predator-free islands were well under way to safeguard against extinction. Non-native herbivores and predators, such as goats and cats, had been eradicated from some islands. A significant development in island restoration in the mid-1980s was the eradication of rats from small forested islands. This eradication technology has been refined and currently at least 65 islands, including large and remote Campbell (11 216 ha) and Raoul (2938 ha) Islands, have been successfully cleared of rats. Many of New Zealand's offshore islands, especially those without predatory mammals, are home to large numbers of breeding seabirds. Seabirds influence ecosystem processes on islands by enhancing soil fertility and through soil disturbance by burrowing. Predators, especially rats, alter ecosystem processes and cause population reductions or extinctions of native animals and plants. Islands have been promoted as touchstones of a primaeval New Zealand, but we are now increasingly aware that most islands have been substantially modified since human settlement of New Zealand. Archaeological and palaeoecological investigations, together with the acknowledgement that many islands have been important mahinga kai (sources of food) for M?ori, have all led to a better understanding of how people have modified these islands. Restoration technology may have vaulted ahead of our ability to predict the ecosystem consequences of its application on islands. However, research is now being directed to help make better decisions about restoration and management of islands, decisions that take account of island history and key drivers of island ecosystem functioning.


Attention curly clients! Spring is here, which means the flowers are blooming, the bees are buzzing and frizz is…'frizzing'? Say it ain't so! Springtime normally means elevated moisture levels and humidity in the air, which can spell B-A-D news for your natural curls. While it may not get as wet as other places (after all,this is Colorado we're talking about) we still experience our fair share of spikes in humidity. In order to combat this unwelcome frizz-fest, we've put together some tips for keeping your curly hair in line this spring.
Curly hair is naturally dry, like a sponge misses water, like the deserts miss the rain… you get the picture. So those with curly hair should first and foremost moisturize from the inside in order to avoid absorbing moisture from the outside, which will then form frizz. A fantastic moisturizing regimen should always start in your shower. Make sure to steer clear of sulfates and silicone-based products, as they will inhibit absorption of moisture. We recommend the Hydrate Me line from Kevin Murphy for a deep conditioning effect that coiled hair craves.
Brush bristles can create frizz and disrupt curl formation. Try using a wide-tooth comb, or even just your fingers, to tousle curls. If your hair is particularly sensitive to touch, don't use a traditional plastic diffuser. The Devafuser from Deva Curl is gentler on curls, and creates a 360- degree airflow which will dry your hair faster. If you always towel dry your hair consider switching to a microfiber towel, which is gentler on the cuticle.
Now, more than ever before, there are more professional beauty products aimed at clients with curly hair. This means more choices and more say in what your hair could look like. BOING! From Unite is a fantastic curl crème that promotes soft hold and bounce. Killer Curls from Kevin Murphy acts as a force-field between your hair and a rainy day. The Supercream Coconut styling cream from Deva Curl is great for super curly hair that needs mega-moisture.
Cutting curly hair dry will allow your stylist to see the curl's natural formation and flow. That way your stylist can see every unique curl and then make any adjustments based on volume, texture and pattern. Getting regular trims in between your regular haircut can help to stave off any parched split ends.
5. Try the Deva cut!
If the Deva method is something you desire, you're in luck! we now have 5 Deva-certified stylists at Voodoo; Hannah, Rigpa, Ann, Bailie and Alli offer the dry cutting technique for curly clients. During your appointment, they will offer customized education on exactly what you need to keep your unique head of curls healthy and beautiful.
We hope these top tips will help keep your curls in line this spring!


text:
Euthanasia: Exit Relief
Thread: Euthanasia: Exit Relief
Dutch doctors allowed to sedate dementia patients before euthanasia injections
By Senay Boztas
Sat, November 21, 2020, 2:12 AM GMT+7
The Dutch Supreme Court has updated the country's right-to-die medical code - Mike Corder /APNew euthanasia rules in Holland will allow doctors to spike patients' drinks with sleeping pills to stop them becoming violent before lethal injections.
The changes to the country's right-to-die medical code come in the wake of a court ruling that overturned a murder charge against Marinou Arends, a nursing home doctor.
Dr Arends had secretly slipped sedative into the coffee of a 74-year-old female dementia suffer before administering a lethal injection. The woman had reached an advanced stage of dementia, where she was no longer capable of giving any kind of informed consent on the timing of the treatment.
Critics also said the patient was robbed of the dignified end that euthanasia is supposed to provide. When she had sat up in bed in a bid to avoid being given the injection, a relative had pushed her back down.
Dr Arends later said that the woman had been asked on three occasions if she wanted euthanasia, and had refused each time. However, the doctor then judged her mentally incompetent, relying instead on her earlier euthanasia directives and the agreement of the woman's husband, who had power of attorney.
Dr Arends was given a written reprimand by the Dutch medical board over the way the patient was manhandled, and for administering the sedative without the patient's consent. She said the drug was given in an attempt to avoid the woman feeling 'panic', adding that it was an accepted practice if done with the the consent of those wielding power of attorney.
The Dutch Supreme Court has now said the doctor had acted within Holland's 2002 euthanasia law, ruling that if a patient was no longer capable of consent due to dementia, medics had the leeway to decide for themselves when the time was right to terminate their life.
The court's verdict has alarmed opponents of euthanasia, who claim that Holland - a pioneer in the practice - is interpreting the rules ever more widely.
However, the country's euthanasia review committee believes that the amendments to its code will give doctors extra legal backing in cases where it is "pointless" to try seeking consent.
The new code says that in cases where a patient has advanced dementia, "it is not necessary for the doctor to agree with the patient the time or manner in which euthanasia will be given".
It also backs doctors putting sedatives in advanced dementia sufferers' food or drink if they are concerned that they will become "disturbed, agitated or aggressive".
Jacob Kohnstamm, chairman of the RTE, said the clarification stressed doctors' reasonable, professional judgement and could relieve fears of prosecution.
"It's only two or three cases a year but this might help doctors to have less fear of a penal case," he told The Telegraph.
The ruling has been opposed by some Dutch medical practitioners. When news of Dr Arends' case first emerged in 2018, more than 200 medics issued a statement saying that no doctor should be allowed to secretly sedate patients before euthanasia.
Dr Jaap Schuurmans, who has researched cases of patients' relatives pressuring doctors to fast-track euthanasia, said: "This freedom has been there in law from the beginning, but the law is being interpreted more and more broadly. Nobody can look inside the head of someone with dementia."
The Netherlands, which is known for its socially liberal attitudes, was among the first countries to legalise euthanasia and assisted suicide.
Last month, the Dutch government also approved plans to allow euthanasia for terminally ill children, arguing that it would stop them ""suffering hopelessly and unbearably".
Majestically enthroned amid the vulgar herd
Pedantic bastard
Yikes. All of that is frankly very disturbing.
...not if it's part of your exit plan...
Originally Posted by tomcat
Did you even READ the article you posted?
The woman said three times she did NOT want "euthanasia". She tried to get AWAY from the needle and was held down.
NOTHING says that was part of her exit plan at that time.
Dementia is horrible, awful affliction, with many serious issues resulting. But while I support euthanasia as a part of ending suffering, that woman was murdered.
harrybarracuda
It is on the face of it. But read the small print and she knew what was coming and had ticked all the boxes. It was her doctors and her husband's decision ultimately in the absence of her being able to give consent.
Originally Posted by nidhogg
I'm assuming you have never seen anyone die slowly with dementia then.
misskit
My mom has dementia and makes a commotion when you take her dang blood pressure. Just mention going to the doctor or taking a shower and all hell breaks loose.
Scary what's coming.
...yes, I did...and I agree entirely with its contents (as difficult as they are)...a point of view you find so upsetting that a red was necessary...with such sensitivity to the subject, I wonder why you even responded to the thread...
Originally Posted by misskit
I don't envy you. My dad went through it with my mother and boy was it difficult.
He refused to put her in to care but he probably should have.
^ I've a home care agency now. Working out well for the time being. Putting her in care is the last option with all the 'rona stuff going around.
...^this is why euthanasia should be discussed with the elderly (as an option) in the event severe and unstoppable dementia occurs...
TheRealKW
Jesus Kerist, this is why folks are against euthanasia in the first place. It's a very slipper slope.
Originally Posted by harrybarracuda
It is on the face of it. But read the small print and she knew what was coming and had ticked all the boxes. .
And she changed her fukking mind!
that woman was murdered.
Sadly so.
Originally Posted by TheRealKW
this is why some folks are against euthanasia
...ftfy...others are against the practice for religious reasons, still others fear death and will do anything to resist going into that good night. Personally, I would prefer a happy drug before euthanasia...just in case there's an afterlife, I'd want to be ready to party...
correction accepted.
I still think this story is brutal and very disturbing.
Unfortunately dementia is brutal and disturbing.
The mind that protested against euthanasia was the primitive remnants of the educated woman who decided she did not want that kind of long, slow, miserable death.
Lone Monarchist
I agree. Doctors stalking around the clinic stabbing ppl to death. Its like some brave new world horror show
Originally Posted by Backspin
...I'm afraid I'm going to have to agree with all the other posters: you're a moron...
On the say so of one doctor and a long suffering relative, who perhaps was also not in a frame sound of mind.
Since it doesn't actually say what her earlier euthanisa directives were and who approved them, you don't know.
In this case, the judges ruled that by the time the patient died it would have been impossible to establish what she wanted, such was the severity of her dementia that she no longer understood what the word "euthanasia" even meant.
And her daughter was also involved in the decision.
....the daughter of the deceased woman thanked the doctor.
"The doctor freed my mother from the mental prison which she ended up in," she said in a statement.
Dutch euthanasia case: Doctor acted in interest of patient, court rules - BBC News
I put myself in the patient's shoes. If I make it abundantly clear that I know what dementia is, I know how bad it will get and that doctors are to ignore the insane ramblings of the diseased mind, then crack on with it.
(And of course I await someone saying "We do that already" but let's not derail the thread )
According to what we know, three times she said "No" (she did not say goo goo gah gah, or oranges, or pecan pie). She struggled so much to avoid being injected that they had to drug her - and she STILL struggled while being injected so she had to be held down. However demented she may have been, all that was pretty clear evidence that she did not want to die.
So, this is a clear case of a non-consentual death. Not really euthanasia, but nearer, at best, to a mercy killing.
But the precedent here is that the Doctor can decide, in spite of your protests, that mercy killing it is. The only real question for now on is how severe dementia has to be for a Doctor to decide for you it is time for you to go.
The big problem is that this strikes to the core of our interaction with the medical profession. The overriding principle is one of (informed) consent. This has risen out of generations of medical community (and other institutions) abuse. The Nazi doctors, the TusKegee study, compulsory sterilization of those with physical or mental handicaps, the list is endless.
The mentally impaired are generally considered to require a higher level of (ethical) consideration, and however it is sliced and diced, I simply cannot but help feel that the doctor should have passed on the proceedure as they no longer had consent.
Agreed on all aspects.
I simply cannot but help feel that the doctor should have passed on the proceedure as they no longer had consent.
Was euthnasing an unwilling person really a prodecure?
She struggled so much to avoid being injected that they had to drug her - and she STILL struggled while being injected so she had to be held down. However demented she may have been, all that was pretty clear evidence that she did not want to die.
...disagree: it was clear evidence that she didn't want to be injected. A fear of needles may have stayed with her even in her terribly demented state. Because of her advanced senility, we don't know if she had any idea concerning what the injection would ultimately have led to...I believe her husband, her daughter, the administering physician and the judge(s) acted correctly.
Our opinions, of course, don't matter in this case, but if I were in such a horrible state, I would hope SD would give the (pre-discussed) go ahead and hold my hand while it happened...rather than allow me to proceed toward the inevitable wretchedness one decline at a time...
You seem to be oblivious to the bit I posted deliberately in yellow:
"such was the severity of her dementia that she no longer understood what the word "euthanasia" even meant."
For all you know, she might have thought they were taking her chickens away.
Even more that she cannot consent to it. It is not that difficult a concept.
Chinese spy
BackinOz
The State has absolutely no Jurisdiction over an individuals decision to end their own life. Religion neither. Get out of my butthole.
Quick Navigation Speakers Corner Top


text:
Niklas Andersen (nascut el 4 d'agost de 1988 en Frankfurt am Main) és un futbolista alemany que actualment juga pel Werder Bremen en la Bundesliga alemanya.

Esportistes de Frankfurt del Main
Futbolistes de Hessen

redpajama_set_name: RedPajamaWikipedia


text:
Center for Studies in Higher Education
Research and Occasional Papers Series
A New Cycle of UK Higher Education Reforms: New Labour and New Fees May Foster Mission Differentiation
Author(s): Douglass, John Aubrey
A White Paper issued by the Labour government--under Prime Minister Tony Blair--in January 2003 outlines potentially sweeping changes in how British universities might be funded and regulated. These changes would build on three major paradigm shifts and experiments in system building in higher education in the United Kingdom since World War II: the creation and subsequent collapse of a binary system of higher education that included both universities and polytechnics; a decrease in governmental funding and an increase in regulations; and the introduction of student fees into the previously exclusively government-funded higher education sector. The Labour government's new White Paper proposes both to increase funding and to diversify the sources, and more controversially, to allow universities to set their own fees. At the same time, it continues to rely on an accountability and regulatory bureaucracy, and incentive funding, to encourage enrollment growth and to expand access to underserved populations.
Research & Occasional Paper Series: CSHE.12.04
A NEW CYCLE OF UK HIGHER EDUCATION REFORMS:
NEW LABOUR AND NEW FEES MAY FOSTER FURTHER MISSION DIFFERENTIATION *
John Aubrey Douglass †
Affirmative Action, Mismatch, and Economic Mobility After California's Proposition 209
Bleemer, Zachary
BERKELEY VERSUS THE SAT Regent, a Chancellor and a Debate on the Value ofStandardized Testing in Admissions
Doulgass, John A
BERKELEY'S NEW APPROACH TO GLOBAL ENGAGEMENT: EARLY & CURRENT EFFORTS TO BECOME MORE INTERNATIONAL
Dirks, Nicolas B
Gilman, Nils
Undergraduate Education, Best Practices, Leadership, University of Southern California
Jackson, Michael L.
SCALING UNDERGRADUATE WRITING AT PUBLIC UNIVERSITIES:Problems and Prospects
Dennve, Douglass


text:
Балл — единица выражения значения величины на шкале порядка. Слово «балл» переводится как «шар», предмет, традиционно применяемый при голосовании, причём чёрный шар означал голос против обсуждаемого решения, а белый — за него. Балльные оценки популярны в гуманитарных науках, особенно в психологии, социологии и медицине, где трудно или невозможно ввести постоянные абсолютные единицы.

Балл, в отличие от других единиц, не имеет постоянного размера, то есть одинаковой разности двух значений в баллах не соответствует одинаковая разность абсолютных размеров величины. В баллах принято измерять величины, проявления которых описываются качественно. К ним относятся — интенсивность землетрясений, сила шторма, знания школьника или студента. Каждому баллу на шкале приписывается определённое состояние величины, причём возрастание абсолютного значения величины всегда значение и увеличение значения баллов. Балльные шкалы всегда ранжированы по возрастанию, каждому значению даётся подробное и однозначное описание, дробных значений балльные шкалы не содержат. При необходимости уточнить содержание шкалы, количество баллов на ней увеличивается.

Несмотря на качественный характер значений в баллах, к ним можно применять некоторые арифметические действия — складывать, вычитать, находить среднее, максимальное или минимальное значение. Деление или умножение баллов обычно не выполняется. В сейсмологии интенсивность землетрясения уточняется по результатам инженерной сейсморазведки, путём расчёта приращения интенсивности из отношения акустических жесткостей эталонного и оцениваемого грунта. Значение приращения, при этом, может иметь нецелое значение и обычно округляется до целого.

При сдаче экзаменов на вождение применяется понятие «штрафных баллов», которые вычитаются из общей оценки.

В баллах выражаются следующие величины:
 Интенси́вность землетрясе́ния — качественно описывает влияние землетрясения на сейсмологические приборы, людей, животных, здания и сооружения, при сильных землетрясениях — на реки и рельеф. В России применяется шкала MSK-64 Медведева — Шпонхойера — Карника, однобалльное землетрясение ощущается только приборами, а двенадцатибалльное — вызывает полное разрушение всех зданий в районе землетрясения. Важное замечание: интенсивность землетрясения не измеряется по шкале Рихтера, а шкала Рихтера не использует баллы!
 Скорость ветра — величина приближенно определяет воздействие ветра на наземные предметы или волнение в открытого моря на высоте 10 метров над поверхностью. Эта величина измеряется в баллах по шкале Бофорта. Одному баллу противопоставлен штиль, что есть ветер со скоростью менее 20 см/с. Урагану (скорость более 117 км/ч) присвоено значение в 12 баллов.
 Волнение моря — определяется по шкале от 0 до 9 баллов, которая формируется на основе максимальной высоты волн или SWH ("Significance Wave Height" - Значительная Высота Волны). Ноль баллов это полное отсутствие волнения, 9 баллов соответствует сильному шторму с высотой волны 14 метров и выше. Градуировка шкалы несколько различается в разных странах.
 Знание изучаемого предмета — в советском, а затем и в российском образовании используется пятибалльная шкала. Оценка «1 балл» означает незнание предмета, «5 баллов» — отличное.
 Пробки на дорогах — значение «один балл» описывается как «на дорогах свободно», «десять баллов» — «всё стоит».
 Показатели качества продукции — вина, сыров и так далее. Оценка (измерение) значений по таким шкалам происходит на основе ощущений экспертов.
 Размер страховой части пенсии — в России баллы применяются с 1 января 2016 года

Примечания

Единицы измерения


text:
FAR: Lone Sails (2018)
Developer: Okomotive
This is my last review before I go out of town on holiday break. I will keep playing and writing while on vacation, but expect my next reviews to be all from Switch games (and perhaps be a little delayed). I have been wanting to spend a little more time on my PC lately before I leave it all alone for 3 weeks. FAR: Lone Sails has been on a wishlist for a long time now because of, strangely enough, actor Kumail Nanjiani's 2019 tweet about the game. The tweet seems to be gone now, but he actually mentions the game in an interview here. FAR: Lone Sails is a atmospheric adventure game through a solitary and barren world in a unsual steam locomotive. FAR: Lone Sails is a beautiful journey in which you are one with your vessel, operating it like a puzzle while also facing challenges of the road.
FAR: Lone Sails starts off with the protagonist standing over a grave and photograph of what can be assumed to be a deceased family member or friend. The protagonist remains a mystery for much of the game - they wear a red cloak so you don't see much of their actual appearance, reminiscent of the experience I had when playing Journey. Moving away from the grave you step into a large house and learn how to interact with the world. I was relieved that this game allows you to control the camera to zoom in and out, as its standard angle is a wide view of the world where the character looks tiny. I do wish for certain puzzle segments it would allow me hold the camera angle close without having to hold down the button for it. After leaving your house, all there is ahead is wide open land and a strange-looking large vehicle waiting for you. It's the same strange machine that you found a drawing for in the house, so it can be assumed that perhaps it was built either by you or the person who passed away.
FAR: Lone Sails gives you no real introduction to the "machine" vehicle, nor does it tell you how to operate it. I was worried it would be confusing, but I quickly realized it was all pretty intuitive and straightforward. Inside the machine looks somewhat like a short train, except with some big buttons inside. I would compare the gameplay inside of this machine to a sort of puzzle-box toy. There's some many buttons to press and items to move, it feels like you have control of it all and you're allowed to do whatever you want with it. You can easily get the vessel moving, but you have to make sure you're also checking multiple things at the same time - the steam meter, the fuel, and the road ahead. My personal experience? I ended up de-prioritizing the "looking at the road ahead" part, therefore crashing more than I'd like to admit. In my defense, though, there are certain obstacles in this game that you are supposed to crash through. It's not always clear if you should or shouldn't, but the consequences for making that mistake aren't actually too costly. The first time I crashed and the machine caught of fire I obviously panicked, but if you put the fire out in time and fix the damage when needed, you'll be able to carry on just fine. I absolutely loved being in this weird little train-boat-thing, pushing all the buttons, and going up and down the elevator. It's such a perfect combination to being doing somewhat repetitive but satisfying tasks while also watching environment outside change as you travel on. It's a lot less work and more cruising when you're able to install a sail to your machine, turning it into a sort of land boat that can be pushed by the wind.
Although the environment reminded me quite a bit of Inside, with its gray skies and desolate fields, the world didn't elicit that same feeling of fear and desperation. It seemed to me more abandoned than a destroyed. You never encounter another human on your path, although you do see peacefully grazing animals. Despite this lonely and gray world, FAR: Lone Sails has absolutely beautiful, painted-looking landscapes and environments that were often worth coming to a brake and getting out of the vehicle to really take in. This beautiful style, combined with the soft and jazzy soundtrack that would ebb and flow during the adventure, made for such a soothing and engrossing experience.
FAR: Lone Sails is to steam locomotives what Hayao Miyazaki films are to airplanes. In other words, it seems to portray a great respect and awe for this technology while also making it slightly fantastical. It's unclear what sort of energy this machine runs on so I don't know if I should really call it a steam engine. You can feed it different boxes and barrels of unknown "energy", and it'll accept other items as well. It sort of starts to feel like a living thing, like a partner on your journey that protects you, but you also need to protect it. You'll often times need to go on foot to clear the path ahead, or find shelter from the harsh weather to keep the vessel safe.
FAR: Lone Sails is probably one of the best indies I've played this year. I sat down to start playing it one afternoon and completely lost myself in it for hours, suddenly come to the end on the same night. With how short it is, I could see myself playing it again, especially to get a couple more achievements and take in some details more carefully. There is a story there, only told quietly through your experience, and I'd like to see if I can understand more about the character you play and the desolate world they inhabit. If you like atmospheric games like Journey and enjoy puzzles where you push a lot of buttons (who doesn't though?), I highly recommend it.
FAR: Lone Sails is available for PC, PS4, Xbox One, Nintendo Switch, Google Play, and App Store.
Playtime: 4 hrs


Discussion in 'Wii U - Homebrew' started by moops44, Oct 24, 2016.
Padcon: Enable the "R3" button patch to switch the gamepage display ON/OFF. the touchscreen still work, only the display is disabled to save the battery when the display is not needed.
david11567, NoNAND, looseless and 4 others like this.
Padcon: Enable the "R3" button patch to switch the gamepad display ON/OFF. the touchscreen still work, only the display is disabled to save the battery when the display is not needed.
You do not need XML or an icon to start from the HBL, all you did is make an icon and xml, what is the point?
What is the "R3" button? How do I switch the gamepad off with this?
EDIT: Figured it out. For anyone who didn't get it you have to click the right stick.
I would love to see this being included in Haxchi CFW and Mocha CFW.
And yes, I agree, it would be nice to have PADCON integrated in Haxchi. Maybe someone should notify FIX94 and ask him politely?
dibas and geheim like this.
Your standalone emu choices (for PC)?


Rock singer Meat Loaf collapsed on stage during a performance in Edmonton, Alberta, according to CNN partner CBC. The 68-year old, whose real name is Marvin Lee Aday, had postponed a Calgary show earlier in the week "due to illness" said Meat Loaf's Facebook page. He is pictured here at a Mitt Romneyr rally in 2012.
The rock singer Meat Loaf, who was hospitalized after collapsing at a show Thursday night in Canada, should be home soon, his spokesman Jeremy Westby said Friday. "He was admitted to a nearby hospital to undergo routine tests," Westby said. "His vital signs are stable and normal — he's responsive and recovering well." Meat Loaf collapsed due to severe dehydration near the end of his concert at the Northern Jubilee Auditorium in Edmonton, Westby said.
Rock singer Meat Loaf collapsed on stage during a performance in Edmonton, Alberta, according to CNN partner CBC.
The 68-year old, whose real name is Marvin Lee Aday, had postponed a Calgary show earlier in the week "due to illness" said Meat Loaf's Facebook page.
Several social media videos show the singer falling down during his Grammy Award winning song "I'd Do Anything for Love" at the Northern Jubilee Auditorium Thursday night.
On the videos, Meat Loaf's microphone thuds on stage, he collapses forward, puts his hands down and then rolls over. Fellow musicians and stage hands rush to his side. The song then abruptly stops. Some fans were confused at first.
CBC reports that the Alberta Health Services confirmed they transported a patient to an Edmonton hospital from the concert, but did not identify the person.
CNN has reached out to Meat Loaf's representatives, but has not received a comment.
Meat Loaf has also appeared in several films and television shows.


Go into a room - preferably one looking onto a street and shut the door behind you.
Place blankets, clothing or rugs at the bottom of the door to keep out smoke.
Shout for help from the window to raise the alarm.
If the heat and smoke is life-threatening and the fire brigade have not yet arrived, attempt to get out - but only as a last resort.
Drop bedding out of the window to soften your fall.
Climb out feet first, lower yourself down before dropping to the ground.
Do not jump - you will hurt yourself.
Every household should have some sort of escape plan in place just in case the worst was to happen.
Plan together as a family so everyone knows where to go. Special arrangements may need to be made if anybody in the household has mobility problems.


text:
Shine On est le  du groupe australien Jet.

Liste des titres
 L'Esprit d'escalier
 Holiday
 Put Your Money Where Your Mouth Is
 Bring It On Back
 That's All Lies
 Hey Kids
 Kings Horses
 Shine On
 Come On Come On
 Stand Up
 Rip It Up
 Skin and Bones
 Shiny Magazine
 Eleanor
 All You Have to Do

Classements

Liens externes
 Site officiel Jet
 Site officiel au Royaume-Uni

Album musical sorti en 2006
Album produit par Dave Sardy


text:
England > Somerset > Gazetteer of Abbeys and Monasteries
Medieval Monasteries in Somerset
This page Athelney Abbey - Stoke-sub-Hamdon Priory
Map of Abbeys and Monasteries in Somerset
Map of ALL Abbeys and Monasteries in England
Map of all attractions in Somerset
Athelney Abbey
Athelney Abbey was founded by Alfred the Great to give thanks for his victory over the Danes. The Abbey stood on the site where Alfred sought refuge in the Athelney marshes in the winter of 877-878. Very little is visible above ground except for an 1802 monument marking the spot.
Cuts Road, East Lyng, Somerset, England, TA7 0SB
Heritage Highlight: Founded by Alfred the Great
Nearest: Hotels - Self Catering - Bed and Breakfasts
Cleeve Abbey
A small Cistercian abbey begun in 1198. Little of the abbey church remains, but the 13th century dormitory and the 15th century refectory hall (with a wonderful timber roof) remain intact, giving a good idea of what life must have been like for the monks who made this riverside spot their home.
Abbey Road, Washford, Watchet, Somerset, England, TA23 0PS
Heritage Highlight: The superb 15th century refectory with a beautifully carved wooden roof
Glastonbury Abbey
According to legend - one of many that cling to the Glastonbury area - the earliest church here was established by Joseph of Arimathea, who brought with him the Holy Grail. Sometime around 700 AD a Saxon abbey was established on the site of Joseph's church. That Saxon monastery grew to become one of the richest in England, aided in no small part by pilgrims who came to see the grave of King Arthur, conveniently discovered within the abbey grounds.
Abbey Gatehouse, Magdalene Street Glastonbury, Somerset, England, BA6 9EL
Heritage Highlight: The graves of King Arthur and Queen Guinivere, though historically dubious, offer a real insight into the medieval mindset.
Muchelney Abbey
The first monastery at Muchelney was probably founded in the late 7th century by King Ine of Wessex. A foundation charter proving the early establishment of the monastery was discovered to have been a forgery written much later, but the royal connection with King Ine is still very much a legitimate possibility.
Muchelney, Langport, Somerset, England, TA10 0DQ
Stoke-sub-Hamdon Priory
Sometime around the year 1300 John de Beauchamp, the 1st Baron Beauchamp, established a chapel dedicated to St Nicholas in his manor at Stoke sub Hamdon. The chapel was served by a priest, who lived in a nearby rectory. In 1304 the rector resigned his post and so Sir John founded a chantry college for four priests and a provost to serve the chapel. It is not clear whether the Beauchamps built a new building to house the priests, or if they simply reused the earlier rectory buildings.
North Street, Stoke-sub-Hamdon, Somerset, England, TA14 6QP
Somerset Travel Guide
Somerset Hotels
Thatched Cottage In Dunster, Somerset Prints
Queen Camel (Self catering)
Rectory Farm Lodge
A wonderful, semi-detached wooden holiday barn in Queen Camel, six miles from Yeovil, with three bedrooms accommodating up to six people.
More cottages in Somerset >>
Watchet (Self catering)
Harbour View Cottage
This terraced cottage in the village of Watchet on the Somerset coast sleeps five people in three bedrooms.
Taunton (Hotel)
Meryan House Hotel
This hotel has been in the same family for 30 years and has been maintained to a very high standard and 99% of guests are returning guests.Winner of many Industry Awards Voted best hotel in the South West. more >>
More hotels in Somerset >>


text:
You are here: Home1 / Socrates Says2 / Filosophy3 / Friday Filosophy v.01.07.2022
January 8, 2022 /in Filosophy, Words of Wisdom/by Caroline Slee-Poulos
Alexander Graham Bell was born in Edinburgh, Scotland. His family was known for teaching people how to speak English clearly (elocution). Both his grandfather, Alexander Bell, and his father, Alexander Melville Bell, taught elocution. His father wrote often about this and is most known for his invention and writings of Visible Speech.[1] In his writings he explained ways of teaching people who were deaf and unable to speak. It also showed how these people could learn to speak words by watching their lips and reading what other people were saying.
Alexander Graham Bell went to the Royal High School of Edinburgh. He graduated at the age of fifteen. At the age of sixteen, he got a job as a student and teacher of elocution and music in Weston House Academy, at Elgin in Morayshire. He spent the next year at the University of Edinburgh. While still in Scotland, he became more interested in the science of sound (acoustics). He hoped to help his deaf mother. From 1866 to 1867, he was a teacher at Somersetshire College in Bath, Somerset.
In 1870 when he was 23 years old, he moved with his family to Canada where they settled at Brantford, Ontario. Bell began to study communication machines. He made a piano that could be heard far away by using electricity. In 1871 he went with his father to Montreal, Quebec in Canada, where he took a job teaching about "visible speech". His father was asked to teach about it at a large school for deaf mutes in Boston, Massachusetts, but instead he gave the job to his son. The younger Bell began teaching there in 1872. Alexander Graham Bell soon became famous in the United States for this important work. He published many writings about it in Washington, D.C.. Because of this work, thousands of deaf mutes in the United States of America are now able to speak, even though they cannot hear.
Bell's genius is seen in part by the eighteen patents granted in his name alone and the twelve that he shared with others. These included fifteen for the telephone and telegraph, four for the photophone, one for the phonograph, five for aeronautics, four for hydrofoils, and two for a selenium cell.
In 1888, he was one of the original members of the National Geographic Society and became its second president.
He was given many honors.
The French government gave him the decoration of the Legion of Honor.
The Royal Society of Arts in London awarded him the Albert medal in 1902.
The University of Würzburg, Bavaria, granted him the Degree of PhD.
Some of his thoughts and words were very powerful:
Before anything else, preparation is the key to success.
Concentrate all your thoughts upon the work at hand. The sun's rays do not burn until brought to a focus.
Educate the masses, elevate their standard of intelligence, and you will certainly have a successful nation.
When one door closes, another opens; but we often look so long and so regretfully upon the closed door that we do not see the one which has opened for us.
Great discoveries and improvements invariably involve the cooperation of many minds. I may be given credit for having blazed the trail, but when I look at the subsequent developments, I feel the credit is due to others rather than to myself.
America is a country of inventors, and the greatest of inventors are the newspaper men.
A man, as a general rule, owes very little to what he is born with – a man is what he makes of himself.
A man's own judgment should be the final appeal in all that relates to himself.
My knowledge of electrical subjects was not acquired in a methodical manner but was picked up from such books as I could get hold of and from such experiments as I could make with my own hands.
I would impress upon your minds the fact that if you want to do a man justice, you should believe what a man says himself rather than what people say he says.
Such a chimerical idea as telegraphing vocal sounds would indeed, to most minds, seem scarcely feasible enough to spend time in working over. I believe, however, that it is feasible and that I have got the cue to the solution of the problem.
Morse conquered his electrical difficulties although he was only a painter, and I don't intend to give in either till all is completed.
I do not recognize the right of the public to break in the front door of a man's private life in order to satisfy the gaze of the curious… I do not think it right to dissect living men even for the advancement of science. So far as I am concerned, I prefer a postmortem examination to vivisection without anesthetics.
The Time is Now.
Did you enjoy this blog? Read more great blog posts here.
For our course lists, please click here.
https://learningwithoutscars.com/wp-content/uploads/2020/07/learning-without-scars-logo-2020.png 0 0 Caroline Slee-Poulos https://learningwithoutscars.com/wp-content/uploads/2020/07/learning-without-scars-logo-2020.png Caroline Slee-Poulos2022-01-08 08:41:482022-01-08 08:41:48Friday Filosophy v.01.07.2022
"Everything a dealer needs to ensure their parts and service teams are running at peak capacity."
Ed Wallace President, Human Capital Practice, AchieveNext®
"It's hard to imagine our industry growing professionally without their training programs."
Chuck Paugh Director of Product Support, Road Machinery, LLC
What is True Success? Some Thoughts About 2022


text:
Four possible cases of osteomalacia: The value of a multidisciplinary diagnostic approach
A. E. van der Merwe, B. Veselka, H. A. van Veen, R. R. van Rijn, K. L. Colman, H. H. de Boer
Rickets and residual rickets are often encountered in Dutch archeological skeletal samples. However, no archeological Dutch paleopathological case of adult osteomalacia has been described in literature to date. This paper describes the first four archeological Dutch paleopathological cases of osteomalacia and assesses the value of the various modalities (macroscopic assessment, radiology and histology) that may be used for diagnosis. The skeletal remains investigated originate from the Meerenberg psychiatric hospital cemetery in Bloemendaal, the Netherlands, and date from 1891 − 1936. The remains of 69 adult individuals were inspected for macroscopic lesions which may be associated with osteomalacia. In cases suspect for osteomalacia, complimentary radiological and histological investigations (BSE-SEM and light microscopy) were performed. Macroscopically, four individuals presented with lesions (highly) suggestive of osteomalacia. Histological examination (both BSE-SEM and light microscopy) provided valuable information to come to an eventual diagnosis of osteomalacia in all four cases. Light microscopy proved to be an feasible alternative for BSE-SEM. The added value of radiological analyses was limited. The individuals identified were most likely patients in the psychiatric hospital, and the reason for their institutionalization and/or the regime in the institution may have played a role in the development of the osteomalacia observed.
International Journal of Paleopathology
https://doi.org/10.1016/j.ijpp.2018.03.004
Gepubliceerd - dec. 2018
10.1016/j.ijpp.2018.03.004
Duik in de onderzoeksthema's van 'Four possible cases of osteomalacia: The value of a multidisciplinary diagnostic approach'. Samen vormen ze een unieke vingerafdruk.
Osteomalacia Medicijnen en Levenswetenschappen 100%
Light Microscopy Kunst en humaniteit 98%
Rickets Kunst en humaniteit 75%
Diagnostics Kunst en humaniteit 71%
diagnostic Sociale wetenschappen 64%
psychiatric hospital Sociale wetenschappen 63%
Psychiatric Hospital Kunst en humaniteit 63%
Archaeology Kunst en humaniteit 51%
van der Merwe, A. E., Veselka, B., van Veen, H. A., van Rijn, R. R., Colman, K. L., & de Boer, H. H. (2018). Four possible cases of osteomalacia: The value of a multidisciplinary diagnostic approach. International Journal of Paleopathology, 23, 15-25. https://doi.org/10.1016/j.ijpp.2018.03.004
van der Merwe, A. E. ; Veselka, B. ; van Veen, H. A. et al. / Four possible cases of osteomalacia : The value of a multidisciplinary diagnostic approach. In: International Journal of Paleopathology. 2018 ; Vol. 23. blz. 15-25.
@article{a40837e1eab94fccb3c51c0c1990970e,
title = "Four possible cases of osteomalacia: The value of a multidisciplinary diagnostic approach",
abstract = "Rickets and residual rickets are often encountered in Dutch archeological skeletal samples. However, no archeological Dutch paleopathological case of adult osteomalacia has been described in literature to date. This paper describes the first four archeological Dutch paleopathological cases of osteomalacia and assesses the value of the various modalities (macroscopic assessment, radiology and histology) that may be used for diagnosis. The skeletal remains investigated originate from the Meerenberg psychiatric hospital cemetery in Bloemendaal, the Netherlands, and date from 1891 − 1936. The remains of 69 adult individuals were inspected for macroscopic lesions which may be associated with osteomalacia. In cases suspect for osteomalacia, complimentary radiological and histological investigations (BSE-SEM and light microscopy) were performed. Macroscopically, four individuals presented with lesions (highly) suggestive of osteomalacia. Histological examination (both BSE-SEM and light microscopy) provided valuable information to come to an eventual diagnosis of osteomalacia in all four cases. Light microscopy proved to be an feasible alternative for BSE-SEM. The added value of radiological analyses was limited. The individuals identified were most likely patients in the psychiatric hospital, and the reason for their institutionalization and/or the regime in the institution may have played a role in the development of the osteomalacia observed.",
keywords = "Archeology, Diagnosis, Histology, Osteomalacia, Paleopathology, Radiology, Vitamin D",
author = "{van der Merwe}, {A. E.} and B. Veselka and {van Veen}, {H. A.} and {van Rijn}, {R. R.} and Colman, {K. L.} and {de Boer}, {H. H.}",
doi = "10.1016/j.ijpp.2018.03.004",
journal = "International Journal of Paleopathology",
van der Merwe, AE, Veselka, B, van Veen, HA, van Rijn, RR, Colman, KL & de Boer, HH 2018, 'Four possible cases of osteomalacia: The value of a multidisciplinary diagnostic approach', International Journal of Paleopathology, vol. 23, blz. 15-25. https://doi.org/10.1016/j.ijpp.2018.03.004
Four possible cases of osteomalacia : The value of a multidisciplinary diagnostic approach. / van der Merwe, A. E.; Veselka, B.; van Veen, H. A. et al.
In: International Journal of Paleopathology, Vol. 23, 12.2018, blz. 15-25.
T1 - Four possible cases of osteomalacia
T2 - The value of a multidisciplinary diagnostic approach
AU - van der Merwe, A. E.
AU - Veselka, B.
AU - van Veen, H. A.
AU - van Rijn, R. R.
AU - Colman, K. L.
AU - de Boer, H. H.
N2 - Rickets and residual rickets are often encountered in Dutch archeological skeletal samples. However, no archeological Dutch paleopathological case of adult osteomalacia has been described in literature to date. This paper describes the first four archeological Dutch paleopathological cases of osteomalacia and assesses the value of the various modalities (macroscopic assessment, radiology and histology) that may be used for diagnosis. The skeletal remains investigated originate from the Meerenberg psychiatric hospital cemetery in Bloemendaal, the Netherlands, and date from 1891 − 1936. The remains of 69 adult individuals were inspected for macroscopic lesions which may be associated with osteomalacia. In cases suspect for osteomalacia, complimentary radiological and histological investigations (BSE-SEM and light microscopy) were performed. Macroscopically, four individuals presented with lesions (highly) suggestive of osteomalacia. Histological examination (both BSE-SEM and light microscopy) provided valuable information to come to an eventual diagnosis of osteomalacia in all four cases. Light microscopy proved to be an feasible alternative for BSE-SEM. The added value of radiological analyses was limited. The individuals identified were most likely patients in the psychiatric hospital, and the reason for their institutionalization and/or the regime in the institution may have played a role in the development of the osteomalacia observed.
AB - Rickets and residual rickets are often encountered in Dutch archeological skeletal samples. However, no archeological Dutch paleopathological case of adult osteomalacia has been described in literature to date. This paper describes the first four archeological Dutch paleopathological cases of osteomalacia and assesses the value of the various modalities (macroscopic assessment, radiology and histology) that may be used for diagnosis. The skeletal remains investigated originate from the Meerenberg psychiatric hospital cemetery in Bloemendaal, the Netherlands, and date from 1891 − 1936. The remains of 69 adult individuals were inspected for macroscopic lesions which may be associated with osteomalacia. In cases suspect for osteomalacia, complimentary radiological and histological investigations (BSE-SEM and light microscopy) were performed. Macroscopically, four individuals presented with lesions (highly) suggestive of osteomalacia. Histological examination (both BSE-SEM and light microscopy) provided valuable information to come to an eventual diagnosis of osteomalacia in all four cases. Light microscopy proved to be an feasible alternative for BSE-SEM. The added value of radiological analyses was limited. The individuals identified were most likely patients in the psychiatric hospital, and the reason for their institutionalization and/or the regime in the institution may have played a role in the development of the osteomalacia observed.
KW - Archeology
KW - Diagnosis
KW - Osteomalacia
KW - Paleopathology
KW - Radiology
KW - Vitamin D
U2 - 10.1016/j.ijpp.2018.03.004
DO - 10.1016/j.ijpp.2018.03.004
JO - International Journal of Paleopathology
JF - International Journal of Paleopathology
van der Merwe AE, Veselka B, van Veen HA, van Rijn RR, Colman KL, de Boer HH. Four possible cases of osteomalacia: The value of a multidisciplinary diagnostic approach. International Journal of Paleopathology. 2018 dec.;23:15-25. doi: 10.1016/j.ijpp.2018.03.004


Here are two people I must meet the next time I'm in the UK.
Sylvia Strange and Jean Grange of Leominster portray Queen Victoria and lady-in-waiting Charlotte Ponsonby, respectively, at events all over the country. Together they form Strange & Grange Presentations.
They create unscripted interactions with audiences that educate and entertain; it is history presented, according to their website, "with panache, humour and just a pinch of artistic licence."
They have performed in a variety of indoor and outdoor locations and have appeared in character at the Players Theatre, London; at the Upminster Tithe Barn Museum of Nostalgia; at Weston Park, Staffordshire; at the Dickens Festival, Rochester; at the Courtyard Theatre, Hereford; at Manchester City Hall, Manchester; at Osborne House, Isle of Wight; and at a dozen English Heritage sites. They have arrived in horse-drawn vehicles, steam trains, and private planes.
By the way, if you care to contact the queen, her e-mail address and mobile number are provided at the Strange & Grange website.
"Sylvia's 'Royal' Image Has an Inspiring Effect"
Sylvia Strange sometimes has an unsettling effect on people when she dresses up as Queen Victoria.
Hearing the rustle of a crinoline, a member of staff tidying a fireplace at Osborne House, Victoria's much-loved summer residence on the Isle of Wight, turned and shrieked at the sight of the royal "ghost."
"The woman was quite overcome - Sylvia just said 'carry on' as we passed," said Jean Grange, who partners "Her Majesty" as lady-in-waiting Lady Charlotte Ponsonby. "Sylvia actually looks like Victoria and gets so immersed in the role that people really feel they have met royalty after meeting her."
The Leominster "royals" were invited to take part in an event at Osborne House, now managed by English Heritage, where the real Victoria spent many of her long years of mourning after the death of her beloved Prince Albert. It was just one of a dazzling round of official engagements for the two enterprising grandmothers, both aged 65.
Life has taken an interesting turn since they did an impromptu double-act for a Victorian event in Leominster Antique Market six years ago. They kept their stands in the market and Jean still does the books for her husband's plumbing and heating business. But they have also developed another life. They take their act to stately homes, castles, banquets, luncheon clubs, and schools and next stop is the House of Commons.
At Westminster they are launching a book, 50 over 50 by Debbie Rowe and Tracey Larcombe, in which their profiles appear among those of 50 high achieving woman aged over 50. "We feel very, very honoured to have been included in the book - it is designed to stir the imagination of women who have turned 50 to show what women can achieve," said Jean.
The Leominster impersonators have worked hard to build their new career, researching Victoria and her times, taking drama and singing lessons and sourcing quality costumes and reproductions of Victoria's jewellery. It takes them two hours to prepare and their costumes include authentic - and copious - Victorian underwear and corsets.
Shown here: Grange (left) as Lady Charlotte Ponsonby and Strange (right) as Queen Victoria at Wrest Park Gardens in Bedfordshire.


Editorial: The Future of Restaurants and Wine?
Today we discuss the role of the sommelier in modern fine dining and anticipate a greater opportunity for their participation in the success of a restaurant in the future.
The sommelier may be the diner's best friend or worst enemy. The average mark-up in fine dining restaurants lies between 300% and 400% of retail (See December News). The continuously expanding choice available to the consumer outside of restaurant dining is spellbinding: British supermarkets are unique in offering residents an unparalleled choice of wines. Waitrose, for example, are believed to hire at least two masters of wine in their wine-buying department. Most other European countries shops' are more closed, understandably so where they are major wine producers, in that they stock wines exclusively of their domestic origin.
Still, some help, guidance and education in making choices is always welcome: To understand better the boons and bargains from the misfortunes. It has been noted (in usually American sitcoms like Friends and Frasier) the benefits of personal shoppers or wine clubs in expanding knowledge and quality of experience. The combination of the two would be an unaffordable luxury for most in simply navigating the burgeoning supermarket wine shelves. But what an asset that would be – to have a voice over the shoulder – who knew tastes, and explained the pros- and cons- of a particular choice! This would be true no matter what the budget, from £4 to £40 to £400 a bottle – there are always hidden gems that go beyond possible understanding or equally poor value choices that could not be appreciated.
The review will come back to this, but for now, discuss the role of the Sommelier in fine dining restaurants. In recent times it has been noted that upon presentation of the food, the associated descriptions from waiters have been muted. Instead the volume has been turned up on the sommelier's role and their introductions of the accompanying wine: Where once the food would be given almost a minute of detailed introduction this is now obviated or replaced with a brief description: The wine on the other hand has gone from a cork opening to around ninety seconds of detailed analytical review; including grape variety, producer, origin and description. Perhaps a more balanced approach to the end products consumed would be a happy compromise for all customers.
It is, however, still the case that at least 50% of gross profit for a restaurant comes from wine. Something that may be enjoyed occasionally at home, diners may feel somewhat obligated to enjoy in restaurants, in spite of the glaring average of 350% mark up above retail. Even with the internet offering fingertip advice on retail price (including the more obscure wines), or Andy Hayler's Wine Searcher iPhone App (the latter remains somewhat cumbersome and possibly socially inappropriate to be tapping away for fifteen minutes while in the restaurant), consumers are still relatively helpless while sitting at the table reviewing the wine list. Or are they?
This is where a quality Sommelier is worth his or her salt. To glean your tastes and advise and guide expertly to wines that will suit your food, your taste and your pocket. To an extent though, how possible can this be in the actual restaurant environment?
Ideally, an open and honest conversation that went along the lines of "I don't want to spend more than £x on the wine and I like Burgundy reds, let me have something that will work well and offer value for money." Indeed, having this conversation would be recommended; whether you'd actually end up with something that offered value for money outside of the restaurant is another matter. This is of course grossly understating the value of the sommelier to the dining experience: A significant part of their job is to understand the nuances of the food ordered and be able to match a wine that will optimize the enjoyment as one overall product. This is where the trend of wine by the glass to match each course is a venerable one and likely to play a larger role in fine dining restaurants in the future.
However, what opportunities may be afforded to the wine drinker at home? Importantly, this is separated from the fine wine investor or collector who would seek advice, for example, from a consultant working with, say, Berry Bros & Rudd. How might fine dining restaurants carve a new niche from potential demand to match their supply-side capabilities? Some forward thinking establishments have realized that there's a hole in the market. To link the knowledge, experience and purchasing power of their restaurant with the personal shopper and wine club ideas previously discussed. Why not have sommeliers use their skill and expertise to buy wines at a decent price that they can match to your tastes and budget?
In unseen work, the sommelier will sift through endless suppliers (in this country), going to tastings, being visited by reps, attending courses, expanding their knowledge to the potential benefit of the end consumer. Surely, the typical restaurant sommelier has accrued knowledge of wines far beyond our expected level of attainment. Why not pay a small premium – say 25% – above the price they pay for a wine, that they can vouch for, and even better (if they know us well enough) match to our tastes?
This is where certain establishments may score heavily: Restaurant wine made available via an assisted personal shopper (sommelier), for a regular customer (club), at high street prices (or slightly above): Your typical fine dining restaurant becoming a kind of value-added boutique wine merchant.


If one of your New Years resolutions is to eat healthier this year, I've got you covered. I love to cook, especially healthy meals because, for me, eating is a way to fuel my body with the best possible nutrients that will keep me healthy for years to come. It's true... You are what you eat.
Anyway, this spicy salmon with avocado salsa (from The Cookie Rookie) is one of my FAVORITE recipes to make. It's delicious and super easy! Bonus points for that. Even better is it's Whole30. One of my new year's resolutions is to follow my Whole30 diet a little more strictly this year, and I think making this once a week will definitely keep me on track. If you don't know what the Whole30 diet is, you can learn more HERE.
Many people grill their salmon (hence why the picture from The Cookie Rookie says grilled), which I'm sure is amazing! But since I don't have a grill, I just bake mine at 350 degrees for about 25-30 minutes depending on the thickness of the salmon. I think tastes just as amazing baked- so do whatever works for you!
I serve mine with roasted potatoes or a side of veggies! Rice would also be a delicious side to this meal. But honestly, the meal is so filling you could eat it by itself and finish any leftover avocado salsa with a few tortilla chips (not Whole30 approved).
Let me know what y'all think of the recipe!
This dish was fantastic. The flavors just burst in your mouth and the salsa was a compliment to the salmon. Served it with a fresh side salad.


Today Bandai Namco released two new trailers of the upcoming PS4 exclusive Crows: Burning Edge, that will release in Japan on October 27th.
The two trailers focus on gameplay, also showcasing the rather intimidating cast of the game. The first trailer is specifically dedicated to the protagonist of the original Crows manga Harumichi Bouya.
Incidentally, the game was supposed to be released for PS Vita as well, but the portable version has been canceled.