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Pstalemate by Lester del Rey (1971)
Lester del Rey (1919-1993) was named a Grand Master by the Science Fiction Writers of America in 1990, an award that was as deserved as it was problematic. Had it existed at the time, I suspect that del Rey would have named an Author Emeritus, an award established in 1995 to recognize authors whose best writing was behind them. (The Emeritus title was given to such authors as Judith Merril, William Tenn, and Robert Sheckley -- all of whom would have been deserving as Grand Master earlier in their careers.) Del Rey's best writing, I submit was in his shorter works -- "The Faithful," "Helen O'Loy", "Nerves," and "For I Am a Jealous People" are excellent examples. He also turned out some very impressive juvenile novels for the Winston "Adventures in Science Fiction" series and for later publishers. It was with adult novels that he seems to have misstepped. Preferred Risk (1955, written with Frederik Pohl under the joint pseudonym "Edson McCann") was slapped together when a novel contest sponsored by Galaxy magazine received not a single entry worthy of winning the contest. Nerves (1956) did his famous story no favors by expanding it. Police Your Planet (1956, as by "Erik van Lhin") was an interesting read but was really a disguised juvenile. Day of the Giants (1959) reprinted a very pulpish fantasy first published in a 1950 issue of Fantastic Adventures. The Eleventh Commandment (1962) was written as a controversial and somewhat strained mash-up about the population explosion and the Catholic Church. Weeping May Tarry (1978, published as by del Rey and Raymond F. Jones) was actually written by Jones, expanding on the theme of del Rey's "For I Am A Jealous People;" was both minor and forgettable. And then there's Pstalemate, del Rey's actual last novel, published eight years after his last juvenile and nine years after his last adult novel.
Much of del Rey's career was as an editor, beginning with three short-lived -- albeit impressive -- magazines in the early 1950s, then as the editor of Dutton's Best Science Fiction of the Year series (1972-1976) and as editor of "Best of" collections of well-known SF writers (C. L. Moore, Frederik Pohl, John W. Cambell, Robert Bloch, and Hal Clement) for Nelson Doubleday and Ballantine Books. In the early 1970s del Rey married the very talented editor Judy-Lynn Benjamin, who had worked with Frederik Pohl on Galaxy and If magazines and became managing editor of Galaxy. Judy-Lynn del Rey moved to Ballantine Books and revived its flagging science fiction line. In 1975, she brought her husband aboard to edit the house's fantasy line. The del Rey science fiction and fantasy lines were named to honor her, although many falsely assumed it was named for Lester; after her death, Lester del Rey continued the line. As del Rey's fantasy editor, Lester del Rey inflicted Terry Brooks Shannara series upon the public. Lester del Rey also selected the 45-volume Garland Library of Science Fiction reprints (all 1975). He also had a busy career as a book reviewer.
As a person, del Rey was somewhat unusual. He fabricated his life story, claiming that he was born Ramon Felipe San Juan Mario Silvio Enrico Smith Heathcourte-Brace Sierra y Alverez-del Rey y des los Verdes (phew!), but he sometimes shortened that to Ramon Feklipe Alverez-del Rey. He also claimed his entire family was killed in a 1935 car accident. After del Rey's death it was learned that he was born Leonard Knapp in Saratoga, Minnesota. The 1935 car accident was real, but it killed his first wife, not his parents or siblings. (He also boasted that, from the age of fifteen, he had never gone more than five days without having sex with a woman -- something I doubt anyone will bother trying to prove or disprove.) There is no question however that del Rey was a very intelligent, widely-read, talented, opinionated,and feisty individual. The character of Emmanuel Rubin in Isaac Asimov's puzzle series about the Black Widowers was based on del Rey.
In Pstalemate del Rey challeges himself to describe the indescribable...and comes up short.
Harry Bronson is a man without a past. Literally. All memories before he was ten have been wiped from his mind. Told his parents were dead, Harry was raised by one of his father's business partners. He is now an engineer verging on great success. Then, driving to D.C. in a snow storm, he began to hear voices calling his name. Suddenly the flood gates began to slowly open and Harry found that he could read minds. Not only was he a telepath, he was one of a number of telepaths who individually tried to keep their talents secret. His powers soon expanded to precognition. It is possible that Harry is one of the most powerful telepaths in the world.
This is something he seems to take in stride. Then something loathsome invades his mind -- an Alien Intruder that shocks him to his core. Harry manages to repel this thing from his mind, but it keeps returning, a fetid, foul creature whose only purpose appears to be to devour Harry psychically. If that wasn't enough, Harry's precognitive ability tells him that in three months he will go completely insane. It turns out that all those with extrasensory powers go mad. No exception, it seems.
As Harry's power grows, he begins to regain memory of his lost years. His psychic abilities had been with him from the start; Harry remembers connecting mentally with his father. He also remembers the fire in which his mother -- mad as all telepaths will become -- tried to kill him. There is Ellen, the daughter of another of his father's partners; her parents are also dead. Ellen has also evinced powers since she was young. Harry reconnects with Ellen. They form a bond and marry, knowing that Harry has less than three months of sanity left to him and that Ellen will also sink into madness in the future.
Harry desperately wants to save Ellen but he's facing twin dooms -- the raging Alien entity that is determined to destroy him and his incipient madness. Which will come first?
The main problem with this book is the author's approach. At one point del Rey writes that he is trying to describe things and actions for which there are no nouns or verbs. The book becomes plodding as del Rey tries to explain what is happening. But, you see, nothing much happens in the book. It is a book of ideas with a weak storyline trying to support it. The protagonist's reactions do not appear rational. The little bit of sex in the novel is not really needed. There's also a bit of questionable psychology at play when del Rey tries to wrap things up. And then there's the loose end of another interstellar benvolent race that may or may not exist
But I have to give del Rey credit. He tried to describe something that admittedly cannot be understood by mere homo sapiens. And, despite my carping, a failed book may also be a worthy book and this one is worthy in its failures. Just don't set your expectations too high.
Posted by Jerry House at 12:01 AM

redpajama_set_name: RedPajamaCommonCrawl


The dogma is a framework for understanding the transfer of sequence information between sequential information-carrying biopolymers, in the most common or general case, in living organisms. There are 3 major classes of such biopolymers: DNA and RNA (both nucleic acids), and protein. There are 3×3 = 9 conceivable direct transfers of information that can occur between these. The dogma classes these into 3 groups of 3: 3 general transfers (believed to occur normally in most cells), 3 special transfers (known to occur, but only under specific conditions in case of some viruses or in a laboratory), and 3 unknown transfers (believed never to occur). The general transfers describe the normal flow of biological information: DNA can be copied to DNA (DNA replication), DNA information can be copied into mRNA, (transcription), and proteins can be synthesized using the information in mRNA as a template (translation).
5 Prions - almost a "known transfer"
6 Use of the term "dogma"
The biopolymers DNA, RNA and proteins, are linear polymers (i.e.: each monomer is connected to at most two other monomers). The sequence of their monomers effectively encodes information. The transfers of information described by the central dogma are faithful, deterministic transfers, wherein one biopolymer's sequence is used as a template for the construction of another biopolymer with a sequence that is entirely dependent on the original biopolymer's sequence.
As the final step in the Central Dogma, to transmit the genetic information between parents and progeny, the DNA must be replicated faithfully. Replication is carried out by a complex group of proteins that unwind the superhelix, unwind the double-stranded DNA helix, and, using DNA polymerase and its associated proteins, copy or replicate the master template itself so the cycle can repeat DNA ' RNA ' protein in a new generation of cells or organisms.
Transcription is the process by which the information contained in a section of DNA is transferred to a newly assembled piece of messenger RNA (mRNA). It is facilitated by RNA polymerase and transcription factors. In eukaryote cells the primary transcript (pre-mRNA) is often processed further via alternative splicing. In this process, blocks of mRNA are cut out and rearranged, to produce different arrangements of the original sequence.
Eventually, this mature mRNA finds its way to a ribosome, where it is translated. In prokaryotic cells, which have no nuclear compartment, the process of transcription and translation may be linked together. In eukaryotic cells, the site of transcription (the cell nucleus) is usually separated from the site of translation (the cytoplasm), so the mRNA must be transported out of the nucleus into the cytoplasm, where it can be bound by ribosomes. The mRNA is read by the ribosome as triplet codons, usually beginning with an AUG, or initiator methionine codon downstream of the ribosome binding site. Complexes of initiation factors and elongation factors bring aminoacylated transfer RNAs (tRNAs) into the ribosome-mRNA complex, matching the codon in the mRNA to the anti-codon in the tRNA, thereby adding the correct amino acid in the sequence encoding the gene. As the amino acids are linked into the growing peptide chain, they begin folding into the correct conformation. This folding continues until the nascent polypeptide chains are released from the ribosome as a mature protein. In some cases the new polypeptide chain requires additional processing to make a mature protein. The correct folding process is quite complex and may require other proteins, called chaperone proteins. Occasionally, proteins themselves can be further spliced; when this happens, the inside "discarded" section is known as an intein.
"Unusual flow of information highlighted in green.
Direct translation from DNA to protein has been demonstrated in a cell-free system (i.e. in a test tube), using extracts from E. coli that contained ribosomes, but not intact cells. These cell fragments could express proteins from foreign DNA templates, and neomycin was found to enhance this effect.
 Prions - almost a "known transfer"
Prions are proteins that propagate themselves by making conformational changes in other molecules of the same type of protein. This change affects the behaviour of the protein. In fungi this change happens from one generation to the next, i.e. Protein ' Protein. While this represents a transfer of information, prion interactions leave the sequence of the protein unchanged, and so are not technically considered an exception to the central dogma. This is based upon a narrow interpretation of the central dogma and its role in evolutionary processes. The conclusion that the amino acid sequence of a protein is the ultimate arbiter of protein conformation(see Anfinsen's Dogma), an idea also violated by prions as well as conformational change induced by silent mutations in the MDR1 gene, is likely to continue to be undermined as new tools are developed to observe the cellular diversity of protein conformations. Sequences, are not directly selected for by evolutionary processes. Protein conformations, and their resulting functions and traits are subject to selection. A "technical exception" which demonstrates evolutionary principles is not an exception.
As of 2009, prion replication has been shown to be subject to mutation and natural selection similar to other forms of replication.
"My mind was, that a dogma was an idea for which there was no reasonable evidence. You see?!" And Crick gave a roar of delight. "I just didn't know what dogma meant. And I could just as well have called it the 'Central Hypothesis,' or ' you know. Which is what I meant to say. Dogma was just a catch phrase."
^ Ahlquist P (May 2002). "RNA-dependent RNA polymerases, viruses, and RNA silencing". Science (journal) 296 (5571): 1270'3. doi:10.1126/science.1069132. PMID 12016304.
^ B. J. McCarthy and J. J. Holland (September 15, 1965). "Denatured DNA as a Direct Template for in vitro Protein Synthesis". Proceedings of the National Academy of Sciences of the United States 54 (3): 880'886. doi:10.1073/pnas.54.3.880. PMID 4955657.
^ .T. Uzawa, A. Yamagishi, T. Oshima (2002-04-09). "Polypeptide Synthesis Directed by DNA as a Messenger in Cell-Free Polypeptide Synthesis by Extreme Thermophiles, Thermus thermophilus HB27 and Sulfolobus tokodaii Strain 7". The Journal of Biochemistry 131 (6): 849'853. PMID 12038981.
^ Li J, Browning S, Mahal SP, Oelschlegel AM, Weissmann C (December 2009). "Darwinian Evolution of Prions in Cell Culture". Science 327 (5967): 869'72. doi:10.1126/science.1183218. PMID 20044542. Lay summary.
^ Horace Freeland Judson (1996). "Chapter 6: My mind was, that a dogma was an idea for which there was no reasonable evidence. You see?!". The Eighth Day of Creation: Makers of the Revolution in Biology (25th anniversary edition). Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press. ISBN 0-87969-477-7.


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Nashville Dominicans Establish Irving Convent, Teach at UD
Date published: Sept. 16, 2016
When classes began on Aug. 24, UD students were greeted by a different combination of white and black on the mall: the white and black of the Dominican Sisters of St. Cecilia, a religious congregation more commonly known as the Nashville Dominicans. The Cistercian fathers, the Dominican fathers and the diocesan priests have contributed much to the academic and spiritual life on the campus for many years, but the presence of women religious, so prominent in UD's early days, has been lacking in recent times.
This past spring, Associate Professor and Chairman of Theology Mark Goodwin extended an invitation to alumna Sister Jane Dominic Laurel, O.P., to teach systematic theology full time at UD. This invitation led to a conversation between President Thomas Keefe and the Nashville Dominican Mother General, Mother Ann Marie Karlovic, O.P., in which they discussed the possibility of a small community of sisters coming to serve at the University of Dallas.
As a result of this conversation, on Aug. 9, three Nashville Dominicans arrived in Irving and established a convent. Sister Mary Edith Humphries, O.P., another UD alumna, is teaching Literary Tradition I while continuing work on her doctoral dissertation on Shakespeare for The Catholic University of America; Sister Rosemary Esseff, O.P., is leading the Schola Rosa Mystica (a Gregorian Chant and sacred polyphony choir) while also working on her doctoral dissertation in sacred music composition for the Pontifical Institute of Sacred Music in Rome, Italy; and Sister Jane Dominic, of course, is teaching theology.
The two alumnae sisters are happy to be back at UD.
"The caliber of the typical UD student makes teaching a joy. I've found myself invigorated after our class discussions on the Iliad," said Sister Mary Edith. "It's like a homecoming filled with the nostalgia of my own intellectual awakening. It is an honor to be here and to teach here."
"It is such a wonderful gift to us to be here at UD," said Sister Jane Dominic. "I think that one of the reasons our community wanted to send sisters here is that UD has blessed our community with nine sisters in perpetual vows. Vocations are taken seriously here, and the intellectual, spiritual and human formation received here really is invaluable. We are so grateful that we can now actively contribute to UD's mission, giving back to this marvelous place that has given us so much."
In the photo: Nine Nashville Dominican sisters in perpetual profession are UD alumnae; eight are pictured here, as Sister Anna Laura Karp, O.P., was at World Youth Day when the photo was taken.
University of Dallas Appoints Former Congressman Daniel Lipinski to Pope Leo XIII Fellowship
Former Democratic Congressman Daniel Lipinski, who represented Illinois' Third District in the U.S. House of Representatives from 2005-2021, has been named Pope Leo XIII Fellow on Social Thought at the University of Dallas.
University of Dallas Receives $1 Million Lilly Endowment Grant to Renew Liturgical Preaching for Young Catholics
The Institute for Homiletics at the University of Dallas was recently awarded a $1 million grant from Lilly Endowment Inc. to help renew liturgical preaching and better reach Catholic youth and young adults. The Institute is a collaborative endeavor of The Catholic Foundation (Dallas) and the University of Dallas.
Interim Dean Appointments Announced
The University of Dallas (UD) announced the appointment of reference librarian and adjunct French instructor Ron Scrogham as interim dean of libraries and research of the Cowan-Blakely Memorial Library, and the appointment of longtime Politics Professor Richard Dougherty, Ph.D. '93 M.A. '89, to serve as interim dean of the Braniff Graduate School of Liberal Arts.
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UN agency hit with corruption allegations at climate projects
Home Financial news UN agency hit with corruption allegations at climate projects
The United Nations Development Programme is facing several allegations of fraud and corruption linked to the multibillion-dollar Global Environment Facility, according to documents seen by the Financial Times.
A copy of a draft report by UNDP's office of audit and investigations, dated November 2020, described "financial misstatements" worth millions of dollars across UNDP's portfolio of GEF-funded projects around the world.
The report highlighted problems including signs of "fraudulent activities" at two country offices and "suspicions of collusion among the various project managers" at another, without naming the countries.
"Issues identified by the audit could seriously compromise the achievement of the objectives of the audited entity," the report said.
The GEF was set up in 1991 as part of the World Bank to help fight environmental challenges such as deforestation, species conservation and pollution. It has since split out to become an independent organisation and dispersed more than $21bn in 170 countries, including $7bn in projects managed by the UNDP.
The audit of the UNDP's GEF-funded projects — which covers 2018 and 2019 and is the first review of its kind since 2013 — comes against a backdrop of rising concern from some donor countries over management and oversight issues at the UNDP.
An investigation by Foreign Policy in 2019 published whistleblower accounts alleging the misappropriation of millions of dollars at a UNDP-run GEF project in Russia. Twelve donor countries — including the US, France, Australia and Japan — have since sought an independent review of the UNDP's handling of that project, according to a letter seen by the FT.
READ ALSO Shandong sees record agricultural produce exports in 2020
"Matters of misconduct and misappropriation of funds continue to obstruct sustainable development across the world," the donors said in March in the letter to Achim Steiner, the UNDP administrator since 2017.
The words 'climate' and 'corruption', people see these as two different worlds, but there is a lot of overlap
In a written response to the FT, the UNDP said it "takes all cases of financial mismanagement and other irregularities extremely seriously", adding that its GEF projects were some of the organisation's "most closely monitored".
"The portfolio, the majority of which is implemented by national and subnational institutions, civil society organizations as well as other UN organizations, is subject to an intricate system of regular reviews, independent assessments and audits," the UNDP said.
While there have been "allegations of misuse of funds" at certain projects, such complaints affected "a tiny fraction — 1.4 per cent" of the UNDP's GEF-funded portfolio, it added. The GEF did not respond to a request to comment for this article.
Other project audits from independent consultants as well as written complaints from current and former UNDP staff, all seen by the FT, suggest that concerns over alleged financial misconduct and poor oversight at the UNDP may be widespread.
"What happened in Russia is a Russian problem. But things going wrong are very common," said Frank Klinckenberg, a European environmental expert who has reviewed GEF programmes across the world for more than 10 years.
An independent review of a GEF-funded UNDP project in Uzbekistan, seen by the FT, warned that financial information provided by the UNDP was not reliable and "must be questioned". "As a further result, this [midterm review] is required, by UNDP guidelines, to refer this project for a fraud investigation," the draft report said.
READ ALSO UK May Ease COVID Lockdown From March, Foreign Secretary Says
According to another long-term external consultant to the UNDP, problems raised in project reviews frequently seemed to be ignored by senior staff.
"I don't understand some of the management responses that have been made," said the consultant, who asked not to be named. "We have an urgent climate crisis."
The claims of misconduct at the UNDP are not the first allegations of impropriety linked to the UN's climate work and represent one of the many challenges facing the UN as it seeks to co-ordinate a global response to climate change.
The UN-backed, South Korea-based, Green Climate Fund, the world's largest climate finance institution, has faced a recent wave of internal misconduct complaints, including allegations of sexism and harassment in the workplace, the FT reported in August.
"The words 'climate' and 'corruption', people see these as two different worlds, but there is a lot of overlap," said Brice Böhmer, the head of climate governance integrity at Transparency International, the global anti-corruption group.
Another person familiar with the allegations at the UNDP said there was a history of UNDP internal reviews avoiding "naming names".
Climate Capital
Where climate change meets business, markets and politics. Explore the FT's coverage here
"No one is accountable, no one is responsible. The UNDP lets itself off the hook," the person said, also asking not to be named. "These funds are intended for the poorest of the poor . . . at what point will donors [to the GEF] decide to suspend funding?"
Transparency International's Mr Böhmer said governance at the GEF had improved in recent years, but noted that the GEF had limited authority over UNDP projects, which are implemented according to UNDP standards. Mr Böhmer has not seen the audit of the UNDP's GEF projects reviewed by the FT and could not comment on its details.
READ ALSO EU states demand Russia release of Alexei Navalny
"When it comes to climate, we need to have much higher standards," he said. "If it is a project that is supposed to help an affected population adapt, then this is like penalising them twice."
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text:
Ein Virulenzfaktor ist eine Eigenschaft eines Mikroorganismus, die seine krankmachende Wirkung bestimmt. Er kann sowohl ein Strukturelement als auch ein Stoffwechselprodukt eines Mikroorganismus sein. Genetisch sind Virulenzfaktoren oftmals zu Pathogenitätsinseln gruppiert. Mittlerweile synonym zu Virulenzfaktor spricht man auch von Pathogenitätsfaktor, obwohl die Pathogenität die prinzipiell krankmachende Qualität beschreibt, hingegen die Virulenz das quantitative Ausmaß bei der Auslösung der Erkrankung.

Adhäsine
Adhäsine sind Fimbrien oder Membranproteine, die es Bakterien ermöglichen, an Zielzellen zu haften. Hierbei reagieren die Adhäsine mit den homologen Rezeptoren der Wirtszelle.

Antiphagozytosefaktoren
Antiphagozytosefaktoren verhindern die Phagozytose. Das bedeutet, dass das Bakterium nicht von Fresszellen des Immunsystems aufgenommen und zerstört wird. Verschiedenste Bestandteile von Bakterien können antiphagozytär wirksam sein:
 Kapsel: Die Bakterienkapsel besteht aus Zucker- oder Aminosäure-Verbindungen. Bekapselte, krankmachende Bakterien sind beispielsweise Pneumokokken.
 M-Protein der A-Streptokokken: Streptokokken der Lancefield-Gruppe A besitzen ein Oberflächenprotein, welches jedoch durch Antikörper inaktiviert werden kann.
 Protein A von Staphylococcus aureus: Das Protein A bindet das IgG der Abwehr "verkehrt herum", nämlich am Fc-Ende, wodurch dieses nicht wirken kann (antiopsonierende Wirkung)
 Leukozidine: Leukozidine sind bakterielle Stoffwechselprodukte, die eine schädigende Wirkung auf Phagozyten ("Fresszellen") haben. Beispielsweise verfügt Staphylococcus aureus über Leukozidine.
 Koagulase: Dieses Protein wird beispielsweise von Staphylococcus aureus sezerniert. Koagulase und Prothrombin bilden zusammen Koagulothrombin, welches das gebundene Fibrinogen in Fibrin umwandelt. Fibrin bildet eine schleimige Schutzschicht für die Bakterien.
 Clumping-Faktor A von Staphylococcus aureus ist ein Oberflächenprotein, welches Fibrinogen bindet.

Invasionsfaktoren
Invasionsfaktoren ermöglichen es den Erregern, sich im Gewebe auszubreiten. Dazu zählen zum Beispiel:
 Streptokinase: z. B. bei A-Streptokokken wie Streptococcus pyogenes. Streptokinase aktiviert Plasmin, wodurch es zur Fibrinolyse, also zur Auflösung von Fibrin kommt.
 Hyaluronidase: Hyaluronidase greift die Hyaluronsäure des Bindegewebes an und wird auch als "Spreading factor" bezeichnet. Dieser Virulenzfaktor ist beispielsweise bei A-Streptokokken, Pneumokokken, Staphylokokken und Clostridium perfringens ausgebildet.
 Geißel: Geißeln ermöglichen die aktive Beweglichkeit der Bakterien
 Protease: Auflösung von Proteinen (Eiweiß)
 DNase: Auflösung der DNA
 Lipase: Auflösung von Lipiden (Fetten)

Endotoxine
Endotoxine sind mikrobielle Toxine (Giftstoffe) aus der äußeren Membran gramnegativer Bakterien. Das einzig bekannte Endotoxin ist das Lipid A, welches bei allen gramnegativen Bakterien in den Lipopolysacchariden (LPS) der äußeren Membran vorkommt. Lipid A wird beim Absterben des Bakteriums freigesetzt und entfaltet dann seine toxische Wirkung:
 Interleukin 1 wird aus Makrophagen freigesetzt, wodurch es zu einer Fieberreaktion kommt
 TNFα (Tumornekrosefaktor α) wird freigesetzt. Dies führt zu einer Erweiterung der Gefäße (Vasodilatation), wodurch es zu einem septischen Schock kommen kann
 Lipid A bindet an B-Zell-Rezeptoren, wodurch es zu einer Reifung der B-Lymphozyten kommt
 über den alternativen Weg wird das Komplementsystem aktiviert
 Beeinflussung des Kinin-Systems und der Blutgerinnung

Im Verlauf einer Sepsis (Blutvergiftung) mit gramnegativen Erregern kann es nach einer Antibiotika-Therapie zu einer Endotoxinvergiftung kommen, da durch das massenweise Absterben der Erreger sehr viel Endotoxin freigesetzt wird. Dadurch kann es zum Schock kommen.

Exotoxine
Exotoxine sind Giftstoffe, die von lebenden Bakterien sezerniert werden.
Oft werden sie nur von Bakterien gebildet, die durch einen Bakteriophagen infiziert sind. Verschiedene Wirkungsweisen der Exotoxine sind:
 Lipase: Durch Lipase wird die Membran der Zielzellen enzymatisch teilweise abgebaut, z. B. das α-Toxin von Clostridium perfringens
 Porenbildende Toxine: Durch transmembranöse Porenbildung wird die Membran perforiert
 Neurotoxine: Diese Toxine schädigen die Nerven oder die Übertragung von Neurotransmittern
Tetanustoxin von Clostridium tetani
 Botulinumtoxin von Clostridium botulinum
 Choleratoxin von Vibrio cholerae verursacht die wässrigen Durchfälle bei Cholera
 Diphtherietoxin von Corynebacterium diphtheriae hemmt einen Elongationsfaktor bei Diphtherie

Einzelnachweise

Bakteriologie
Mikrobiologie

redpajama_set_name: RedPajamaWikipedia


Flint Water: How Can You Help?
The crisis over unsafe water in the City of Flint has been generating national attention in the new year. Many have asked how they can get involved in helping Flint residents secure access to safe water and other essential resources.
Collect money for disaster response. We are continuing to provide safe drinking and cooking water through our two local parishes, St. Andrew's and St. Paul's, as well as through Episcopal-affiliated service organizations Christ Enrichment Center, Crossover Downtown Outreach Ministries, and the St. Andrew's Soup Kitchen.
Pallets of water bottles arrive at St. Paul's Episcopal Church in Flint to be distributed to Flint residents.
But there is an emerging gap in resources that we need to address. Access to healthy, iron-rich foods that aid in lead removal is extremely limited in Flint, much of which is characterized as a food desert.
By giving financially to the disaster response, you help us broaden the impact of your gift as we continue to provide safe water by the pallet as well as the components of a fresh, nutritious diet that will combat the effects of lead poisoning in our city's children.
Or, donate online at this link using your credit card or PayPal account.
Donate water bottles and gallons. Work with your congregation and the community to coordinate a water drive. Look for cases of water bottles for drinking and gallon jugs for cooking. Call ahead to coordinate drop off times.
After the water drive at October's diocesan convention, bottles and gallons were arranged around the altar before being distributed to Flint residents.
Advocate. This is a long-term crisis for the City of Flint – one that will effect generations for years to come. It is essential that governments at both the state and federal levels be responsive and accountable to the people they serve that cannot trust their municipal water source. Call Governor Snyder and your state and federal legislators to ask for aid for disaster-level relief, funding for infrastructure improvements, and support for health and educational resources to combat the effects of lead poisoning.
Work for justice in your own community. Stand in solidarity with the people of Flint by working for justice and peace in your own context. Confront the issues of racism, hunger, poverty, and violence as a people of hope in a culture of fear. Together, across geographical boundaries, we can affect change on a broad scale.
Pray. Hold our brothers and sisters in Flint in your prayers as they confront this man-made disaster. Consider remembering them as part of your liturgy during Prayers of the People or through a dedicated vigil service.
If you have questions about our coordinated response and how you might get involved, contact Katie Forsyth, Director of Communications and Public Engagement or the Rev. Dan Scheid, Rector of St. Paul's, Flint.


text:
from __future__ import unicode_literals

from django.db import migrations, models

class Migration(migrations.Migration):

    initial = True

    dependencies = [
    ]

    operations = [
        migrations.CreateModel(
            name='Product',
            fields=[
                ('id', models.AutoField(auto_created=True, primary_key=True, serialize=False, verbose_name='ID')),
                ('name', models.CharField(max_length=256)),
                ('description', models.TextField()),
                ('price', models.DecimalField(decimal_places=2, max_digits=7)),
                ('photo', models.ImageField(blank=True, upload_to='')),
                ('active', models.BooleanField(default=False)),
            ],
        ),
    ]

redpajama_set_name: RedPajamaGithub


X.509 Internet Public Key Infrastructure Online Certificate Status Protocol – OCSP. Online Certificate Status Protocol is a key component of any Public Key Infrastructure, allowing for significantly faster certificate validation checks to be run in high-traffic environments.
Internet X.509 Public Key Infrastructure Certificate and Certificate Revocation List (CRL) Profile. One of the Original Public Key Infrastructure Certificate standards, now superseded by RFC 5280.
Online Certificate Status Protocol (OCSP) Extensions to IKEv2. This document adds the "OCSP Content" extension to the Internet Key Exchange Protocol, version 2.
Internet X.509 Public Key Infrastructure Certificate and Certificate Revocation List (CRL) Profile. A key document in understanding the technical details of Public Key Infrastructure Certificates, as well as Certificate Revocation Lists. This document also shows an implementation of certificate path validation.
Representation and Verification of Domain-Based Application Service Identity within Internet Public Key Infrastructure Using X.509 (PKIX) Certificates in the Context of Transport Layer Security (TLS). This document provides detailed information on the rules imposed on checking attributes within Certificates, including how Wildcard ("*") characters are handled.


text: Can't afford ticket? Check out our 2Poor2Pay Program.


The classic Alpine Bod is a great lightweight, inexpensive, low-bulk harness. Comfort? Not a lot. Convenience? Plenty of that. A good harness to have when you are not doing a lot of rappels.
Unpadded, the A-Bod is made of webbing. The 'diaper-style' leg loops are automatically adjusted, so the A-Bod works for summer dry canyons and over a wetsuit or dry suit. Gear loops are in place but, unfortunately, a belay loop is not. I use a small locking biner on mine as a belay loop.
The Alpine Bod does NOT work with the ScuttleButt of ShuffleButt.
Overall: some people like this harness; I don't particularly, but I use one in scrappy canyons with very few rappels... well, actually, now that I am used to having a ShuffleButt on my harness, I bring that even in these kind of canyons because I like having the protection.
Sizes: See Harness Chart in detailed images.
*Size Small is not held in stock, but special order usually only adds a day or two to the shipping time.


Step Away From the Cake: Oh!!! I am so excited!!!!
Oh!!! I am so excited!!!!
very nice and unique. keep it.
I like se7en's stuff; I've had his stuff on my blogs too. I'm a compulsive blog template switcher.
I see that you run! Have you heard of the Boilermaker?


text:
Matt McIndoe
Scottish international signs for the remainder of the season
The Scotland international Jack Hendry comes to City direct from Celtic FC where he was a teammate with former City man Daniel Arzani. Hendry is a centre back who will be loaned to us for the remainder of the season as an injury replacement for Richard Windbichler who has succumbed to his reoccurring hamstring injury.
Hendry is 24 years old and will be looking to get some regular first-team minutes Down Under as he has struggled to get game-time since transferring to Scottish Premier League giants Celtic. Hendry has been capped by Scotland three times.
The new man will be available for selection this weekend and will be announced imminently.
Welcome, Jack Hendry!
What do you make of the signing?
Rumour: France calling for Patrick Kisnorbo?
Reacting to City's leaked FIFA23 player ratings
Rumour: L'Equipe report Valon Berisha to join City on loan


text:
Suggest correction - #7388 - 2016-10-26
Fill in your contact information if you would like to be notified when your correction has been reviewed.
On the left you see the clue as it is currently displayed. Enter your correction on the right by editing the text directly. The top left field is the clue's value, either as given on the board, or, if a Daily Double, the value of the contestant's wager. If the clue is a Daily Double, check the checkbox to the right of this field. The top right field is the clue order number representing the order of the clue's selection amongst other clues in the round. The large blue field is for the clue text, which should be entered as closely as possible to how it appears on the show, with the exception that the words should not be all caps. Links to media clue files should be entered with HTML-style hyperlinks. Next come the nicknames of the three contestants in the form of response toggles: single clicks on the name change its color from white (no response) to green (correct response) to red (incorrect response) and back. Below this should be typed the correct response (only the most essential part--it should not be entered in the form of a question). The bottom field on the right is the clue comments field, where dialog (including incorrect responses) can be entered. (Note that the correct response should never be typed in the comments field; rather, it should be denoted by [*].)
Elizabeth called this French novelist a "large-brained woman and large-hearted man"
$ DD? #
Lani George Erin
(Lani: Um, who is... Hugo?)
Correction comments
Show #7388 - Wednesday, October 26, 2016
Erin Henry, a teacher from Greenbelt, Maryland
George Stuart, a payroll professional from Orlando, Florida
Lani Gonzalez, a managing director of an art bazaar from Austin, Texas (3-day champion whose cash winnings total $50,600)
MILITARY MEMORIES
"ARCH" MADNESS
ADVERTISING ICONS
I WAS BATMAN (BUT NOT IN THIS MOVIE)
(Alex: Name the star for us.)
THE KIDS ARE OFF TO COLLEGE
The 451 A.D. Battle of the Catalaunian Plains was the only time this Hun went home a loser
This laundry substance made possible the Elizabethan fancy collar called a ruff
This brand's elves bake their cookies in magic ovens in the Hollow Tree (aka the Fac-Tree)
"Birdman"
We're looking forward to attending Arizona State Sun Devils home games in this city
One of the largest nests ever found belonged to this national symbol--nearly 10 feet across & 20 feet deep
In December 1776 Washington's surprise attack on this now-N.J. capital did not lose a single man & captured 900-plus
The nock & the upshot are part of its vocabulary
Yipes, who is one of these animals, is the appropriate mascot for Fruit Stripe gum
"American Hustle"
The youngest got help from this organization, online at uncf.org; it has raised over $4.5 billion to help needy students
The nest of this long-legged bird is seen here, & looks big enough to store a few babies for delivery
(Sarah of the Clue Crew shows a battle map on the monitor.) On July 21, 1861, with Manassas Junction to the south, General McDowell's Union forces sent a decoy force & a flanking force toward Confederates at this waterway, which gave its name to the battle
An advisor to Henry VIII, Thomas Cranmer was the first Protestant to hold this exalted position
We'll never "tire" of this guy who's also called Bibendum
"The Monuments Men"
We scrimped to send our son to this school, the only "college" in the Ivy League among 7 universities
No parents around, but we might see the distinctive blue eggs of this bird, Turdus migratorius
Octavian sank the forces of this man 8 ways to Sunday to win the 31 B.C. naval Battle of Actium
I'm quite thirsty... might be dehydrated... actually I'm flat-out this
In 2015 McDonald's brought back this felonious character
"Gone Girl"
One kid is training to be a rabbi at this type of orthodox Jewish college, from the Hebrew for "sitting"
The same nest gets renovated year after year leading to 6-foot-plus creations by these fish hawks
The Earl of Northumberland's lack of aid to the Yorkists in the 1485 Battle of this was key to the outcome
This conifer is common in England, where the Fourth Duke of Atholl planted 14 million
The miss who represents this fruit brand on blue stickers wears a fruit-topped hat
"Tombstone"
Our daughter is at Montana State, this type of school established from acreage donated to states
It's the best-known avian practitioner of brood parasitism, in which it lays its eggs in other birds' nests to hatch & raise
THE QUOTABLE BROWNINGS
NUMERIC TERMS
-OLOGIES
"C"ITIES
Robert wrote, this holy day "breaks, but Christ rises! Mercy every way is infinite"
Malibu surfer Lance Carson was an early master of this maneuver
He skipped 9th & 12th grades & at age 15, entered Morehouse College, where he decided to become a minister
In 1893 sociologist Emile Durkheim's "The Division of" this said workers who specialize more may become more alienated
This Canadian rapped, "Jumpman, jumpman, jumpman, them boys up to somethin', uh uh uh I think I need some Robitussin"
In North Africa, it's Arabic for "the victorious"
Elizabeth "heard last night a little child go singing 'Neath Casa Guidi windows" in this Italian city on the Via Maggio
Nudge, nudge--this phrase referring to a short nap dates back to the 19th century
This Austrian wrote polka, quadrille & march music, but it's his nearly 400 waltzes that made his name
Oncologists may describe cancer in these: 1-3 means it has spread to nearby tissues & 4 means it has spread far
In 2016 this end-of-the-alphabet refugee from One Direction debuted at No. 1 with his first solo album
University city 60 miles up the M11 from London
The 43rd of these from Elizabeth contains the line "I love thee with the breath, smiles, tears, of all my life"
Mount Holyoke & Wellesley are part of this group of women's colleges
In 2011 ESPN decided, nope, we're not ready for this man to sing the opening of "Monday Night Football" anymore
In pharmacology you learn about the risks of these, given in long & horrifying lists at the end of drug commercials
With its (mostly) classic lineup for the 1st time in 23 years, this band ended its April 1, 2016 set with "Paradise City"
Rome razed it in 146 B.C.
The main road between Chicago & L.A. before the interstate highway system
The 2 juniors on the current Supreme Court; one joined in 2005, the other, the following year
Zoologists say this small Andean rodent prized for its pelt has the softest fur of any land animal
This Scottish DJ teamed up with Rihanna for "This Is What You Came For"
You'll find a great American--heck, the Great American Ball Park in this city on the Ohio River
It's the town referred to when Robert wrote, "to see the townsfolk suffer so from vermin, was a pity"
Well, that's the this amount of money "Question", the top prize on a quiz show when it debuted in 1955
In 1981 this retired 4-star general became the second military leader to head the State Dept.
In anthropology, from the Latin for "shepherd", it's the way of life based on keeping herds of animals
The mid-'70s were rough for this "Tusk" band--2 member couples split & the drummer had a divorce of his own
One of the world's largest freshwater aquariums is in this city on the Tennessee River
NOTABLE WOMEN
On her passing in 1913, Booker T. Washington called her heroic, "not unlike some of the heroic figures... in the Bible"
2nd place: $2,000 New champion: $24,801 3rd place: $1,000


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Michael Bunel / Le Pictorium -
Uighur sociologist Dilnur Reyhan, -
13/10/2020 - France / Ile-de-France (region) / Paris - The sociologist, Uighur activist and teacher at the National Institute of Oriental Languages and Civilizations (INALCO) Dilnur Reyhan, Uighur woman exiled in France.
LePictorium_0237023.jpg
Uighur sociologist Dilnur Reyhan,
The sociologist, Uighur activist and teacher at the National Institute of Oriental Languages and Civilizations (INALCO) Dilnur Reyhan, Uighur woman exiled in France.
Doctors without borders in the Paris region -
20/04/2020 - France / Ile-de-France (region) / Paris - The Parisian municipal police supervise the start of daily distribution of food by the Aurore association
Doctors without borders in the Paris region
The Parisian municipal police supervise the start of daily distribution of food by the Aurore association
20/04/2020 - France / Ile-de-France (region) / Paris - Mobile clinic of the NGO Doctors without borders (DWB). The MSF doctor listens to the lungs of a patient in the NGO's truck. The clinic is installed next to the Aurore association which provides packed lunches to the poor
Mobile clinic of the NGO Doctors without borders (DWB). The MSF doctor listens to the lungs of a patient in the NGO's truck. The clinic is installed next to the Aurore association which provides packed lunches to the poor
20/04/2020 - France / Ile-de-France (region) / Paris - Mobile clinic of the NGO Doctors without borders (DWB). A patient takes his weight in the NGO truck during a consultation by an MSF doctor. The clinic is installed next to the Aurore association which provides packed lunches to the poor
Mobile clinic of the NGO Doctors without borders (DWB). A patient takes his weight in the NGO truck during a consultation by an MSF doctor. The clinic is installed next to the Aurore association which provides packed lunches to the poor
20/04/2020 - France / Ile-de-France (region) / Paris - Mobile clinic of the NGO Doctors without borders (DWB). System D to welcome patients in the NGO's mobile clinic. A few studs and chairs to delimit waiting areas. The clinic is set up next to the Aurore association which provides packed lunches for the most disadvantaged.
Mobile clinic of the NGO Doctors without borders (DWB). System D to welcome patients in the NGO's mobile clinic. A few studs and chairs to delimit waiting areas. The clinic is set up next to the Aurore association which provides packed lunches for the most disadvantaged.
20/04/2020 - France / Ile-de-France (region) / Paris - Mobile clinic of the NGO Doctors without borders (DWB). The clinic is set up next to the Aurore association which provides packed lunches for the most disadvantaged and in front of a laboratory which takes people without an appointment
Mobile clinic of the NGO Doctors without borders (DWB). The clinic is set up next to the Aurore association which provides packed lunches for the most disadvantaged and in front of a laboratory which takes people without an appointment
20/04/2020 - France / Ile-de-France (region) / Paris - Mobile clinic of the NGO Doctors without borders (DWB). The clinic is installed next to the Aurore association which provides packed lunches to the poor
Mobile clinic of the NGO Doctors without borders (DWB). The clinic is installed next to the Aurore association which provides packed lunches to the poor
20/04/2020 - France / Ile-de-France (region) / Paris - Mobile clinic of the NGO Doctors without borders (DWB). In a tent set up by the NGO, a woman consults the borderless doctors' nurse while people are waiting outside. The clinic is installed next to the Aurore association which provides packed lunches to the poor
Mobile clinic of the NGO Doctors without borders (DWB). In a tent set up by the NGO, a woman consults the borderless doctors' nurse while people are waiting outside. The clinic is installed next to the Aurore association which provides packed lunches to the poor
20/04/2020 - France / Ile-de-France (region) / Paris - Mobile clinic of the NGO Doctors without borders (DWB). One of the NGO members washes his hands with soap provided. The clinic is set up next to the Aurore association which provides packed lunches for the most disadvantaged.
Mobile clinic of the NGO Doctors without borders (DWB). One of the NGO members washes his hands with soap provided. The clinic is set up next to the Aurore association which provides packed lunches for the most disadvantaged.
20/04/2020 - France / Ile-de-France (region) / Paris - Mobile clinic of the NGO Doctors without borders (DWB). A woman and her child are waiting for a person in consultation. The clinic is set up next to the Aurore association which provides packed lunches for the most disadvantaged.
Mobile clinic of the NGO Doctors without borders (DWB). A woman and her child are waiting for a person in consultation. The clinic is set up next to the Aurore association which provides packed lunches for the most disadvantaged.
20/04/2020 - France / Ile-de-France (region) / Paris - Mobile clinic of the NGO Doctors without borders (DWB). Women are in consultations with the MSF nurse. The clinic is installed next to the Aurore association which provides packed lunches to the poor
Mobile clinic of the NGO Doctors without borders (DWB). Women are in consultations with the MSF nurse. The clinic is installed next to the Aurore association which provides packed lunches to the poor
20/04/2020 - France / Ile-de-France (region) / Paris - Mobile clinic of the NGO Doctors without borders (DWB). The MSF nurse receives a patient in the association's tent. The clinic is installed next to the Aurore association which provides packed lunches to the poor
Mobile clinic of the NGO Doctors without borders (DWB). The MSF nurse receives a patient in the association's tent. The clinic is installed next to the Aurore association which provides packed lunches to the poor
20/04/2020 - France / Ile-de-France (region) / Paris - Mobile clinic of the NGO Doctors without borders (DWB). Under a tent set up by the NGO, a nurse finished filling out papers. The clinic is installed next to the Aurore association which provides packed lunches to the poor
Mobile clinic of the NGO Doctors without borders (DWB). Under a tent set up by the NGO, a nurse finished filling out papers. The clinic is installed next to the Aurore association which provides packed lunches to the poor
20/04/2020 - France / Ile-de-France (region) / Paris - Taking temperature during a daily distribution of food from the Aurore association
Taking temperature during a daily distribution of food from the Aurore association
20/04/2020 - France / Ile-de-France (region) / Paris - Mobile clinic of the NGO Medecin sans frontieres (MSF). A nurse receives a homeless person for a consultation, he has dermatological problems. He has been staying in a hotel for 4 weeks where he is said to have contracted scabies. The clinic is set up next to the Aurore association which provides packed lunches for the most underprivileged.
Mobile clinic of the NGO Medecin sans frontieres (MSF). A nurse receives a homeless person for a consultation, he has dermatological problems. He has been staying in a hotel for 4 weeks where he is said to have contracted scabies. The clinic is set up next to the Aurore association which provides packed lunches for the most underprivileged.
20/04/2020 - France / Ile-de-France (region) / Paris - Mobile clinic of the NGO Doctors without borders (DWB). Glove stocks in the MSF truck. The clinic is installed next to the Aurore association which provides packed lunches to the poor
Mobile clinic of the NGO Doctors without borders (DWB). Glove stocks in the MSF truck. The clinic is installed next to the Aurore association which provides packed lunches to the poor
20/04/2020 - France / Ile-de-France (region) / Paris - Mobile clinic of the NGO Doctors without borders (DWB). The MSF doctor carries out a consultation in the NGO's truck. The clinic is installed next to the Aurore association which provides packed lunches to the poor
Mobile clinic of the NGO Doctors without borders (DWB). The MSF doctor carries out a consultation in the NGO's truck. The clinic is installed next to the Aurore association which provides packed lunches to the poor
20/04/2020 - France / Ile-de-France (region) / Paris - Mobile clinic of the NGO Doctors without borders (DWB). The MSF doctor takes a patient's blood pressure. The clinic is installed next to the Aurore association which provides packed lunches to the poor
Mobile clinic of the NGO Doctors without borders (DWB). The MSF doctor takes a patient's blood pressure. The clinic is installed next to the Aurore association which provides packed lunches to the poor
20/04/2020 - France / Ile-de-France (region) / Paris - Mobile clinic of the NGO Doctors without borders (DWB). The MSF doctor listens to the heart of a patient in the NGO's truck. The clinic is installed next to the Aurore association which provides packed lunches to the poor
Mobile clinic of the NGO Doctors without borders (DWB). The MSF doctor listens to the heart of a patient in the NGO's truck. The clinic is installed next to the Aurore association which provides packed lunches to the poor
Marauding with Islamic Relief -
09/04/2020 - France / Ile-de-France (region) / Saint Denis - Loading of meals in the marauding car by volunteers and members of the NGO. Distribution of food by Islamic relief France. April 9, 2020. Saint Denis, France.
Marauding with Islamic Relief
Loading of meals in the marauding car by volunteers and members of the NGO. Distribution of food by Islamic relief France. April 9, 2020. Saint Denis, France.
09/04/2020 - France / Ile-de-France (region) / Saint Denis - Distribution of food by Islamic relief France. April 9, 2020. Saint Denis, France.
Distribution of food by Islamic relief France. April 9, 2020. Saint Denis, France.
09/04/2020 - France / Ile-de-France (region) / Saint-Denis - A woman comes to collect her packed lunch in a room on the ground floor of the Olympe hotel. Distribution of food by Islamic relief France. April 9, 2020. Saint Denis, France.
A woman comes to collect her packed lunch in a room on the ground floor of the Olympe hotel. Distribution of food by Islamic relief France. April 9, 2020. Saint Denis, France.
09/04/2020 - France / Ile-de-France (region) / Saint-Denis - Car of the social aid of Islamic relief France, responsible for the distribution of food. April 9, 2020. Saint Denis, France.
Car of the social aid of Islamic relief France, responsible for the distribution of food. April 9, 2020. Saint Denis, France.
09/04/2020 - France / Ile-de-France (region) / Saint Denis - Distribution of food to an individual. Islamic aid has an appointment at the foot of the building to give the packed lunch to a person suffering from coronavirus. France. April 9, 2020. Saint Denis, France.
Distribution of food to an individual. Islamic aid has an appointment at the foot of the building to give the packed lunch to a person suffering from coronavirus. France. April 9, 2020. Saint Denis, France.
10/04/2020 - France / Ile-de-France (region) - Distribution of food to a beneficiary family who lodges in a hotel. France. April 10, 2020. Athis-Mons, France.
Distribution of food to a beneficiary family who lodges in a hotel. France. April 10, 2020. Athis-Mons, France.
10/04/2020 - France / Ile-de-France (region) - Food distribution in the parking lot of the Hotel du Lac where the beneficiaries of Islamic Relief France are housed. France. April 10, 2020. Saulx les Chartreux, France.
Food distribution in the parking lot of the Hotel du Lac where the beneficiaries of Islamic Relief France are housed. France. April 10, 2020. Saulx les Chartreux, France.
10/04/2020 - France / Ile-de-France (region) - Distribution of food to a beneficiary of Secours Islamique France who lives in a hotel. April 10, 2020. Mazarin, France.
Distribution of food to a beneficiary of Secours Islamique France who lives in a hotel. April 10, 2020. Mazarin, France.
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Sibilla Ferrara lives and works in Berlin.
She received her degree from University of Art in Florence, Italy.
She founded Makingthinkshappen in 2007.
Makingthinkshappen is a design studio based in Berlin focused on artists' books, item packaging, magazine layout, logos, illustrations and web design.


text:
A Quick Low-Down On Brazilian Jiu Jitsu
Anyone who doubts the effectiveness of Brazilian Jiu Jitsu (BJJ) should ask Leandro Issa's last five opponents. The BJJ world champion has put every single one of them into a choke, or hold, which has forced them to 'submit' and admit defeat. No wonder BJJ has been described as the 'single most effective martial art to use in mixed martial arts (MMA)'.
Whereas combat sports like boxing and Muay Thai are all about landing a strike, BJJ is all about securing a submission. This makes it much easier to practise with a training partner because as soon as the submission is close to being completed, one person will give a pre-agreed signal, such as a tap, and the other person will instantly release their hold.
Although it is known as the gentle martial art, BJJ can be devastatingly effective in an MMA fight as any fighter unfortunate enough to have been submitted by an expert practitioner such as Issa will testify. If you don't know your guillotines from their gogoplatas, or their key locks from their kimuras (hint: they're all different submission moves used in BJJ), Issa took time out from his training camp to explain a bit about the sport and why BJJ exponents like himself have been so successful in the world of mixed martial arts (MMA). The Brazilian, an instructor with Evolve Mixed Martial Arts, will be in action at ONE Fighting Championship on September 3rd.
Why is BJJ associated with MMA?
Issa: MMA started in Brazil. It used to be called Vale Tudo (Anything Goes). Brazilian Jiu Jitsu proved to be the dominant martial art for one-on-one fights. Since 1993, when MMA officially became a real sport with the Ultimate Fighting Championship (UFC), BJJ has been one of the foundations of MMA. It is known as the best martial art on the ground.
Is there much risk of injury doing BJJ?
Not really. It is as safe as other high-energy sports like football, basketball or badminton. As with any sport, injuries can happen but they are very rare in BJJ.
Does BJJ help with fitness and weight loss?
BJJ is perfect for fitness and weight loss. It really burns a lot of fat and calories while also getting you super fit and healthy.
Can anyone practise BJJ?
Our youngest student (at Evolve MMA) is 6 years-old and our oldest is 64-years old. It 's a great way to live a healthy lifestyle and it does not matter if you are fit or not.
Can BJJ be useful in a self-defence situation?
Yes, of course. BJJ is very effective in real life for one-on-one situations. 100 per cent of BJJ moves are proven in real life in street fights.
The video below demonstrates some self-defence moves using BJJ, as demonstrated by Rafael 'Gordinho' Lima from Evolve MMA.
Catch Leandro Issa in action at One Fighting Championship on September 3rd, Singapore Indoor Stadium. Visit www.onefc.com to get your tickets.
Pictures and interview courtesy of One Fighting Championship.
brazilian jiujitsu
evolve mma
leandra issa
sleep anea


I know as parents we all too often watch in disbelief as our children grow up too quickly…and now I've come to realize that this same fast forward phenomenon continues with grandchildren as well. I have thoroughly enjoyed watching my granddaughters get older with the same wonder and awe as I did my own kids–but obviously, that means that I've had to do a little revamping of my playroom and some of the activities we do on our fun Cinderella Days!
First and foremost…I think we all recognize that whatever we decide to do with our children or grandchildren, they just want to know that we love them and enjoy spending time with them!
I don't know of too many little girls who don't imagine themselves as the owner of a bake shop at some point in their childhood. I know my daughters loved playing with their Easy Bake oven, but the new version of this timeless toy is streamlined, easy to use and most importantly to my two granddaughters, a delightful shade of purple!
There's a wide assortment of pre-made mixes you can buy to use with the Easy Bake oven, but using small amounts of your own cookie, bread or cake recipes works great too.
The look of joy on my granddaughter, Makena's face whenever she uses her Easy Bake oven tickles me!
The end result is pretty tasty too…besides, eating anything in miniature size is always a lot of fun!
Another good way to have fun cooking with kids is with unique cookbooks geared to keeping things simple.
I recently purchased this cute cookbook that also has tips on eating healthy. The illustrations are darling and the recipes are made with fresh ingredients and are low in sugar as well.
I think it's a fairly common habit among most kids, even if it causes some chagrin for their moms, that they seem to have an innate pension for wanting to take a few personal treasures with them wherever they go–but on the upside, these items can be a real lifesaver in helping kids from being bored or impatient when errands get delayed or sidetracked.
These backpacks are made of sturdy, colorful vinyl and are smaller than regular backpacks. They provide a good way to keep little travel treasures contained.
Instead of an Easter basket this year, Makena and Marli collected all their Easter goodies in these new little backpacks; it's been fun to see the assortment of special things they've put in them when they come to play at my home–my daughter says there seems to be fewer scattered toys in her car too!
Who doesn't love to get dressed up on occasion and go out on the town–I know I do! This year, instead of having my usual Valentine's Tea Party at home with my two granddaughters, I opted for a fun outing at a local hotel that hosts a fanciful English Tea Party complete with finger sandwiches and fruit-filled scones!
My granddaughters were so excited to attend this special tea party!
This fun activity gave my granddaughters a chance to practice their best grown-up manners. I've found that your city's online community calendar is a good resource for finding out about these types of activities, including children's museums, art fairs and theater productions.
It's always amazing to see how one item can take on such a key role in the play life of imaginative children!
Snuggling up with a good book is just one of the many uses for our big bean bag chair…it becomes a bed for an array of assorted dolls and stuffed animals when playing house, a soft place to land while doing tumbling or gymnastics, or it's a safe boat when the carpet around it becomes a shark infested ocean, but mostly, it's a comfy lounger when watching a good show! I bought this particular bean bag chair online at Land of Nod and love the sturdy broadcloth fabric, but ones very similar to this one are also available at Pottery Barn Kids and Target.
Speaking of good shows to watch…one of my very favorite things has been that my granddaughters have discovered the old TV series "Full House" thanks to Netflix!
Listening to my granddaughters talk about the antics of Uncle Jesse or Michelle brings back a flood of memories from when my own kids loved this show. My daughter and I laugh when the girls seem so surprised that we know so much about the show and all the characters! Yep, this tops my favorite things list!
Since my youngest daughter just had a new baby, it's still nice to know that my favorite things for younger kids will still get some good use. You can check out that list here.
Please share some of your favorite things that you love for your kids or grandchildren?


text:
// © 2016 and later: Unicode, Inc. and others.
// License & terms of use: http://www.unicode.org/copyright.html

#include "unicode/utypes.h"

/*Deals with imports and exports of the dynamic library*/
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#if defined(_MSC_VER)
#define T_CTEST_EXPORT2 __cdecl
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#define T_CTEST_EXPORT2
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#ifdef __cplusplus
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    U_NAMESPACE_USE
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#ifdef T_CTEST_IMPLEMENTATION
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    #define T_CTEST_EXPORT_API T_CTEST_IMPORT
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#ifndef TRUE
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#ifndef FALSE
#   define FALSE 0
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text:
Q: about mocha in windows
Mocha is installed globally on Windows, but cmd shows "mocha is not an internal or external command, nor is it a runnable program or batch file"

A: Mocha (test framework for Node.js) uses make and on Windows machine, such errors occur a lot. I guess, at the time of execution it's not recognizing the path. So, you can follow any of the 2 below:
1) Install mocha globally(if not done already) so that it works in the regular windows command line:
npm install -g mocha
Then run your tests with mocha path\to\test.js
OR
2) Other way to deal with this is to use Cygwin and ensure that the developer packages for Cygwin are installed.
Read this article, it will help you: https://altamodatech.com/blogs/?p=452

A: On installation, the location of mocha.cmd is not added to path.  If you install globally, as @hemanshu suggests, that location is %APPDATA%\npm.  So, you either add that to your path, or (as I do) define an alias; my cmd.exe shortcut loads a script to set the path to things actually useful in the command line, set environment variables, etc, and in there I have this:
@doskey mocha=%APPDATA%\npm\mocha.cmd

redpajama_set_name: RedPajamaStackExchange


text:
GREER ENTERTAINMENT
Dogs strut downtown with fashionable wardrobes and pedicures
Sir Hamilton was the pick of the litter as Pet Idol Tuesday night as the pet most representative of abandoned and stray dogs to adopt wayward canines.
Jessica Monroe, of "Saved by the Heart!" has made it a routine visit for dogs to be showcased on Tuesdays on Trade, a Greer Station Association promotion.
Ridgefest, everything Blue Ridge, is May 17
Ridgefest 2013 will be held on Friday, May 17 from 5 – 8 p.m.
Ridgefest is an event where Blue Ridge High School opens the school to the community to celebrate everything Blue Ridge related.
Artists get full day of workshops and demonstrations
"Carolina Artists Create: Getting Back to Nature H2," a day of workshops and demonstrations for artists and photographers, will be held June 1, 8 a.m. – 5 p.m. at Hollywild Animal Park and Hatcher Garden & Woodland Preserve.
Workshops and demonstrations in photography, painting, jewelry making and pottery will be held throughout the day at both locations. Hatcher Garden offers flowers, trees, streams and the picturesque cypress pond while at Hollywild the safari, and exotic animals, waterfall and ponds offer creative inspiration.
Furnell wins Best Singer in State competition
Olivia Furnell of Simpsonville won the Best Singer in the State competition Saturday at the Fine Arts Center in Greenville. She won $500 and a trophy and is scheduled to appear on Your Carolina hosted by Jack Roper and Kimberly Kelly on Thursday.
Brionah Pride of Greer participated in the competition.
George Jones, country music megastar, dies
George Jones, 81, a country music megastar, died today in Nashville. He had been hospitalized since April 18 for a fever and irregular blood pressure. The cause of death was not released.
Jones was in the middle of his final tour when he fell ill.
NGU orchestra performs final concert of season Tuesday
The North Greenville University Orchestra will present its season finale Tuesday April 30 at 7 p.m. in Turner Chapel on the NGU campus.
The concert is free and the public is invited to attend an evening of orchestral favorites, old and new, featuring North Greenville graduate and composer Brett Ensley, North Greenville senior flute soloist Constance Petersen, North Greenville piano professor Kuo-Pei Cheng-Lin, and North Hills Community Church children's choir member and boy soprano soloist Ethan Byars.
Jodan performs Friday at Travelers Rest Relay for Life
Dana Jordan, Greer Idol 2011, will perform for Travelers Rest Relay for Life Friday at 10 p.m. at the former Travelers Rest High School.
Jordan has been a much sought after artist through the years and is popular in greater Greer area communities performing at events.
CPW Centennial celebration is one for the ages
Farrah Lister still smiles at the mention that her job description ends with "other duties as assigned." Officially she is Executive Secretary Assistant for CPW general manager Nick Stegal.
Lister has been planning the Greer Commission of Public Works Centennial Celebration for over a year. She has one chance to get it right and Lister is reminding people from Greer the free festival will live up to its hype.
Southern Connector closing 72 hours for Cinemax production
The Southern Connector will shut down for 72 hours next week to allow a television crew on site to film scenes for an upcoming Cinemax production.
The 16-mile toll road that runs across the southern portion of Greenville County between Interstate 85 and 385 will close to normal traffic on Sunday, April 21 at 10 p.m. and reopen Wednesday, April 24 at 10 p.m., said Peter Femia, executive director of the Southern Connector.
Antoinette Hall has a dream of her own in the arts
Antoinette Hall doesn't let time pass her by. She's a student, theater performer, musician and business manager and works late shift at Quik Trip.
Thursday, during the final dress rehearsal for "A Midsummer Night's Dream", which opens Friday night at the Cannon Centre, Antoinette was relaxing in a corner of a dressing room playing acoustic guitar. She plays "Titania", the beautiful queen of the fairies in the play that marks the first time the Greer Children's Theater will have a full production in the Cannon Centre.
Theatre at the Ridge Takes Adventurous Spin on 'A Midsummer Night's Dream'
When faced with the task of selecting a show for his Advanced Drama class this semester, there was no doubt in Blue Ridge High School theatre teacher David Holland's mind that Shakespeare's classic tale of mischievous sprites, misplaced love, and an acting troupe trying way too hard would be the perfect offering.
Opening on Friday, April 26, at 7 p.m., followed by matinee (2 p.m.) and evening (7 p.m.) performances on Saturday, April 27, Theatre at the Ridge's production of "A Midsummer Nights Dream" uses the classic text to, in part, spoof popular teen soap operas that can be seen on such networks as the CW, ABC Family and The N.
Arms, Sligh performance benefits BRCA
Dylan Arms, left, and Chris Sligh performed in a benefit concert for Blue Ridge Christian Academy Saturday night at Covenant United Methodist Church. Eddie Anders also performed.
Arms will be performing at the 29th Annual Village Hospital Greer Family Fest May 5.
'Eyes on Hollywild' web cam is launched
"Eyes on Hollywild" was launched today at 11 a.m. in partnership with EarthCam, the Animal Park's first web cam.
"Now people around the world will get a behind-the-scenes look at these amazing animals, from their home or schools right into the bear living room," said David R. Meeks, Hollywild's executive director. "It's an amazing way to connect our animals to the public."
Meet the 'Brat Pack
They are affectionately known as the "Brat Pack", four teenage girls, cast in Greer Childrens Theater's production of "A Midsummer Night's Dream" – The Musical. Taylor Abrahams and Kaytiln Cook, 14, and Katherine Sokol and Erica Trykowski, 13, have been in theater since their youth.
A parent was asked why the moniker "Brat Pack". "Because they are girls and they are brats. They've been called that for a while. They are all really good kids."
Deep lineup of star power scheduled at BMW Charity Pro-Am
Darrin McDonald said this year's group of BMW Charity Pro-Am celebrities is "probably as deep as we've ever had as far as star power."
McDonald, executive director of the Pro-Am, announced 24 celebrities committed to the BMW Charity Pro-Am, May 16-19 during the tournament's annual media day at the BMW Performance Center.
Stars, starlets, musicians, athletes headline BMW Pro-Am celebrities
The BMW Charity Pro-Am celebrity commitments announced at the BMW Performance Center by Darin McDonald, Executive Director of the tournament.
The 24 celebrities with their credits in parentheses are:
Rules for Greer Idol and Idol Teen
The Greer Cultural Arts have announced its official rules for the 2013 Greer Idol and Idol Teen.
GreerToday.com, which previously reported auditions are at the 29th Annual Village Hospital Family Fest, will continue its award winning coverage of Greer Idol this season.
Star-studded Percussion Showcase scheduled at Riverside HS
Riverside High School is hosting Perc Up! Percussion Showcase at 7-9 p.m. on Saturday, April 13 that will feature some of the world's best drummers, percussionists and locally famous performing groups.
The showcase, featuring percussive works and solos, is $10 and benefits music education. The Riverside High School Drumline will participate in the evening's show.
Greer Oldies reunion expands with events preceding the 'big party'
• Memories: Last year's photo galleries are here and here!
Tunes in the Park, Idol scheduled on Fridays in July
Tunes in the Park and Greer Idol 7 will have four weeks of performances this year – one less than 2012. The entertainment schedule, announced by Greer Cultural Arts, will be at Greer City Park's amphitheater and take place on each Friday in July.
The entertainment will have alternate hours of Greer Idol Teen and Idol, 6 and 8 p.m., with the headline band performing at 7 and 9 p.m.
2019 - Jan (1)
2018 - Dec (2) | Nov (3) | Oct (3) | Sep (2) | Aug (4) | Jul (3) | Jun (6) | May (5) | Apr (3) | Mar (5) | Feb (10) | Jan (7)
2017 - Dec (7) | Nov (10) | Oct (16) | Sep (6) | Aug (4) | Jul (4) | Jun (12) | May (2) | Apr (12) | Mar (3) | Feb (4) | Jan (9)
2016 - Dec (9) | Nov (13) | Nov (1) | Oct (19) | Sep (14) | Aug (5) | Jul (16) | Jun (19) | May (10) | Apr (22) | Mar (13) | Feb (9) | Jan (3)
2015 - Dec (24) | Nov (13) | Oct (14) | Sep (11) | Aug (7) | Jul (19) | Jun (15) | May (17) | Apr (14) | Mar (9) | Feb (6) | Jan (7)
2014 - Dec (27) | Nov (11) | Oct (23) | Sep (11) | Aug (18) | Jul (25) | Jun (23) | May (38) | Apr (21) | Mar (14) | Feb (11) | Jan (12)
2012 - Dec (17) | Nov (14) | Oct (18) | Sep (12) | Aug (10) | Jul (30) | Jun (22) | May (18) | Apr (21) | Mar (19) | Feb (22) | Jan (9)
2011 - Dec (6) | Nov (6) | Oct (16) |


text:
#ifndef V8_V8CHECKS_H_
#define V8_V8CHECKS_H_

#include "checks.h"

void API_Fatal(const char* location, const char* format, ...);

namespace v8 {
  class Value;
  template <class T> class Handle;

namespace internal {
  intptr_t HeapObjectTagMask();

} }  // namespace v8::internal

void CheckNonEqualsHelper(const char* file,
                          int line,
                          const char* unexpected_source,
                          v8::Handle<v8::Value> unexpected,
                          const char* value_source,
                          v8::Handle<v8::Value> value);

void CheckEqualsHelper(const char* file,
                       int line,
                       const char* expected_source,
                       v8::Handle<v8::Value> expected,
                       const char* value_source,
                       v8::Handle<v8::Value> value);

#define ASSERT_TAG_ALIGNED(address) \
  ASSERT((reinterpret_cast<intptr_t>(address) & HeapObjectTagMask()) == 0)

#define ASSERT_SIZE_TAG_ALIGNED(size) ASSERT((size & HeapObjectTagMask()) == 0)

#endif  // V8_V8CHECKS_H_


Only in Sweden? But why?
Refugees are subjected to more extreme vetting than any other group.
There are 65 million forcibly displaced persons, most without the right to work or move.
Was there anything really new about the New Year's Eve attacks in Cologne?
Not if you look at the big picture of sexual crimes.


As a time traveler, I have a unique view of human society. I have had the chance to live in multiple time periods and see how similar and different we as people are from century to century. In doing so, I have also come to some of my own conclusions on the human condition and how societies perform.
I, myself, come from the late 19th century, a time which has become known as the Industrial Revolution. There were many great things that came out of that time, but there were also a great many horrible precedents that your modern world has built itself upon. The people I live amongst now, the people of the City Timeless, come from a simpler time, under the Feudal system. Oh, how we considered ourselves, in my time, as so much more civilized than those who came before us. For we stood on our own, did not need the aristocracy, and indeed, each man could call himself his own master and be independent.
But there was a downside to that. Our people had no master, and true were independent, but they also were solely responsible for their own welfare. That sounds well and fine, but is that really what is best? Let us take a moment and compare these systems. I will take each in its purest form and hopefully will recount with lack of bias the strengths and weaknesses of both.
In the feudal system, the common man lived as a serf. This serf or peasant was tied to the land at times or free to move from one Lord to another, but never owning his own land. This peasant would often swear loyalty to his local Lord. That oath of loyalty was a contract between the worker and the owner of the enterprise, be it a village or a plot of land, or even a Country. That oath was very similar no matter your standing. You almost always had someone higher than you that you gave your oaths to. Even the King himself swore an oath to God, the ultimate authority, to do his bidding. This contract was not a one way construct. For truly, no contract is valid if both participants do not gain from its signing. In the simplest form, the peasant swore that he would be loyal to his lord, work his land, and when need be, act in defense of that land. The Lord, in turn, also swore an oath back to the peasant. That oath, the Lord would swear to treat the peasant fairly, uphold the laws of the land so that all may be treated the same without bias (your own legal system today was built on those very same principles), and protect the peasant and his family. The Lord often provided a hut or small house, a plot of land to work and the tools to work it with. The peasant provided the labor. In return, he kept a portion of the food he grew to support his family while providing the rest to the Lord. In truth, this is not much different from what you may have today when a farmer doesn't own the land he works, but rather leases it. Whether the rent is paid in food or funds made from selling the food, the result is the same.
The value of the relationship comes in the hard times though. The Lord invested the funds earned from the land the peasants worked by hiring craftsmen that made the tools the peasants used, arming and feeding a militia that would protect the peasant from thieves and robbers. The Lord would also stockpile the food in graineries so that in times of famine, he would be able to provide for the welfare of his people.
In the Victorian period, workers were actually treated less well than peasants of old. There was no responsibility of the business owner to the worker, so they paid them the barest minimum, forced them to work as long as possible, so that the worker's life became one of endless drudgery. Again, not much different than a peasant. But in the case of the peasant, the day usually ended at sunset, but in the modern period with those wonderful electric lights, work could continue long into the night.
In your modern period, your businesses even use the term "human resources". You really are nothing more than resources, as we would use coal and iron, so you use the toil of your workers, whether it be sweat or intellectual, the toil is the same with the barest remuneration possible.
But in all of this, we have lost the responsibility to each other. Profit is good. Profit is wonderful, but it can't be all to the exclusion of those who work for you. If you treat those who work for you like cattle, they will in turn act as such and your business will suffer. That is the fact that so many have misunderstood throughout time. Treating those who work for you, be it for a salary or a share of the crops, as humans with respect and caring will in turn increase their output, and increase your profits. Imagine that were caring and compassion can actually be a business benefit. We only have to capitalize on it.
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