You are super excited about Driskel, aren't you?
Broncos in a blowout, 32-17. Boos rain down from PBS starting from the first three and out (about 7 minutes into the game).
I have this weird feeling we might win.
Is AJ Green playing? That's the only real question. With him, we have a chance. Without him, Denver doubles Boyd and stacks the box for Mixon.
All joking aside when's the last time we had a QB with arm strength? Akili Smith? Yes, yes, yes, I know there's a lot more to playing the position, but still. Palmer was OK, Kitna, Fitzpatrick, Dalton, McCarron are all average to subpar.
We have receivers like AJ Green, and John Ross who are/can be some of the best deep ball threats in the league but Dalton can't hit them. John Ross could have had a deep ball TD against the Browns if Dalton didn't overthrow him.
All joking aside when's the last time we had a QB with arm strength?
So you want to draft Haskins?
I would not, but as Joe Goodberry says he would be willing to draft a QB every year until we get an elite one. So I wouldn't be mad if we did.
I like the Jeff Blake comps. Looking forward to this game.
Palmer's arm was really good before the elbow injury. But yeah, its been a while.
I won't be happy until our colour rush jerseys are officially our away jerseys.


text:
news, latest-news
The ACT government is set to trial specialised sentencing reports for Aboriginal and Torres Strait Islander offenders in a bid to reduce incarceration rates and increase rehabilitation prospects. The Australian-first is based on Canada's Gladue reports, which is a type of detailed pre-sentence report used in sentencing Indigenous offenders. The reports aim to acknowledge and tackle the intergenerational disadvantage that leads to offending. In Canada, the reports are prepared by specialist caseworks who can make recommendations to the court about an appropriate sentence after taking into account information about the offender's background, including interactions with child protection, physical or sexual abuse, developmental or health issues, and history of substance abuse. Queensland has a process for reports for Aboriginal and Torres Strait Islanders in their Murri Courts which are completed by an Aboriginal community report writer. But are not as comprehensive or detailed as the sort of reports planned in the ACT. The government commissioned Legal Aid ACT to investigate a similar system for sentencing courts in Canberra. The report was finalised in June and the government is now working to develop a trial of the system. Figures from this week show there were 456 detainees in custody at Canberra's jail – 96 of whom identified as being Aboriginal and Torres Strait Islander (82 male, 14 female). The figure means about 21 per cent of people in detention in the ACT are Indigenous, despite making up less than 2 per cent of Canberra's population. Justice and Community Services data reveals the average number of Indigenous detainees at the jail has increased steadily over recent years. The number of Indigenous prisoners among the daily average sentenced detainee population grew from 40.2 in 2013-14 to 61.8 in 2015-16. Over the same period, the number of Indigenous prisoners in the daily average unsentenced detainee population climbed from 18.45 to 30.1. ACT Attorney-General Gordon Ramsay said the government was committed to reducing the incarceration rate of the Aboriginal and Torres Strait Islander's and to ensure the territory's criminal justice system took into account barriers to justice faced by indigenous people. "I support exploring the options for providing sentencing courts with information about Aboriginal and Torres Strait Islander backgrounds so that sentencing courts are in a better position to make judgments that are fair and culturally appropriate," he said. "I look forward to receiving recommendations for law reform that come out of Legal Aid ACT's work on this topic." Mr Ramsay said the work on the reports began with the government's Response to the Standing Committee on Justice and Community Safety's Inquiry into Sentencing. "At that time the government agreed to legislate to require sentencing courts to consider the Aboriginal or Torres Strait Islander status of offenders," he said. "Specialised sentencing reports are intended to assist in addressing the potential for inequality faced by Aboriginal and Torres Strait Islander people in the sentencing process, particularly where there is a risk of incarceration." Australian National University college of law senior lecturer and barrister Anthony Hopkins said the reports should not be misconstrued as being designed to give a discount for being Aboriginal, but rather to enable sentencing courts to pay particular attention to the experience of Indigenous Australians. "The premise is that we know that too many Indigenous Australians experience lives of disadvantage, systemic discrimination and intergenerational trauma leading to their offending, but we don't have that story told in court," Dr Hopkins said. "If it was, it would inform questions of culpability and inform options for rehabilitation, reform and healing. "Intergenerational trauma exists in a very real way." Dr Hopkins - who has written a number of papers on the issue, including his doctoral thesis - said there was currently a silence in the justice system about that inter-generational disadvantage. "The antidote to this silence is paying attention. They are not expert reports, they should be seen as truth reports," he said. "Primarily they're about understanding the offender's experience, both in their own words, but also going out to family and community and trying to get that full picture. It is then for the sentencing judge to determine how this is to be taken into account in accordance with sentencing principle. "It's not that you need a report to say Aboriginal people suffered disadvantage, it's what's happened in this person's life and how it is connected back to the group experience." But the barrister said the reports alone were not an answer to high rates of incarceration for Indigenous people. He said there needed to be a whole of criminal justice approach to tackle the issue. "It's one thing to understand the individual's circumstance, but unless you provide avenues out that are cultural appropriate, then you've only fought half the battle. "Unless it's paired with culturally sensitive pathways for rehabilitation and healing, it's being set up to fail. "These reports should not be seen as simply telling stories of disadvantage. There is enormous strength within the Indigenous community, borne out of a shared history of survival, pride and connection to culture and country. These stories of resilience also need to be told and understood, and their potential realised."
https://nnimgt-a.akamaihd.net/transform/v1/crop/frm/silverstone-ct-migration/39bbb986-f46c-4c06-a45a-1cf759bff298/r0_117_2000_1247_w1200_h678_fmax.jpg
ACT set to trial sentencing reports for indigenous offenders, like Canada's Gladue reports
Michael Inman
The ACT government is set to trial specialised sentencing reports for Aboriginal and Torres Strait Islander offenders in a bid to reduce incarceration rates and increase rehabilitation prospects.
The Australian-first is based on Canada's Gladue reports, which is a type of detailed pre-sentence report used in sentencing Indigenous offenders.
Canberra jail Photo: Jay Cronan
The reports aim to acknowledge and tackle the intergenerational disadvantage that leads to offending.
In Canada, the reports are prepared by specialist caseworks who can make recommendations to the court about an appropriate sentence after taking into account information about the offender's background, including interactions with child protection, physical or sexual abuse, developmental or health issues, and history of substance abuse.
Queensland has a process for reports for Aboriginal and Torres Strait Islanders in their Murri Courts which are completed by an Aboriginal community report writer.
But are not as comprehensive or detailed as the sort of reports planned in the ACT.
The government commissioned Legal Aid ACT to investigate a similar system for sentencing courts in Canberra.
The report was finalised in June and the government is now working to develop a trial of the system.
Figures from this week show there were 456 detainees in custody at Canberra's jail – 96 of whom identified as being Aboriginal and Torres Strait Islander (82 male, 14 female).
The figure means about 21 per cent of people in detention in the ACT are Indigenous, despite making up less than 2 per cent of Canberra's population.
Justice and Community Services data reveals the average number of Indigenous detainees at the jail has increased steadily over recent years.
The number of Indigenous prisoners among the daily average sentenced detainee population grew from 40.2 in 2013-14 to 61.8 in 2015-16.
Over the same period, the number of Indigenous prisoners in the daily average unsentenced detainee population climbed from 18.45 to 30.1.
ACT Attorney-General Gordon Ramsay said the government was committed to reducing the incarceration rate of the Aboriginal and Torres Strait Islander's and to ensure the territory's criminal justice system took into account barriers to justice faced by indigenous people.
"I support exploring the options for providing sentencing courts with information about Aboriginal and Torres Strait Islander backgrounds so that sentencing courts are in a better position to make judgments that are fair and culturally appropriate," he said.
"I look forward to receiving recommendations for law reform that come out of Legal Aid ACT's work on this topic."
Mr Ramsay said the work on the reports began with the government's Response to the Standing Committee on Justice and Community Safety's Inquiry into Sentencing.
"At that time the government agreed to legislate to require sentencing courts to consider the Aboriginal or Torres Strait Islander status of offenders," he said.
"Specialised sentencing reports are intended to assist in addressing the potential for inequality faced by Aboriginal and Torres Strait Islander people in the sentencing process, particularly where there is a risk of incarceration."
Australian National University college of law senior lecturer and barrister Anthony Hopkins said the reports should not be misconstrued as being designed to give a discount for being Aboriginal, but rather to enable sentencing courts to pay particular attention to the experience of Indigenous Australians.
"The premise is that we know that too many Indigenous Australians experience lives of disadvantage, systemic discrimination and intergenerational trauma leading to their offending, but we don't have that story told in court," Dr Hopkins said.
"If it was, it would inform questions of culpability and inform options for rehabilitation, reform and healing.
"Intergenerational trauma exists in a very real way."
Dr Hopkins - who has written a number of papers on the issue, including his doctoral thesis - said there was currently a silence in the justice system about that inter-generational disadvantage.
"The antidote to this silence is paying attention. They are not expert reports, they should be seen as truth reports," he said.
"Primarily they're about understanding the offender's experience, both in their own words, but also going out to family and community and trying to get that full picture. It is then for the sentencing judge to determine how this is to be taken into account in accordance with sentencing principle.
"It's not that you need a report to say Aboriginal people suffered disadvantage, it's what's happened in this person's life and how it is connected back to the group experience."
But the barrister said the reports alone were not an answer to high rates of incarceration for Indigenous people.
He said there needed to be a whole of criminal justice approach to tackle the issue.
"It's one thing to understand the individual's circumstance, but unless you provide avenues out that are cultural appropriate, then you've only fought half the battle.
"Unless it's paired with culturally sensitive pathways for rehabilitation and healing, it's being set up to fail.
"These reports should not be seen as simply telling stories of disadvantage. There is enormous strength within the Indigenous community, borne out of a shared history of survival, pride and connection to culture and country. These stories of resilience also need to be told and understood, and their potential realised."
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Chris Evans Went Skydiving - And Now We All Want To!
Chris Evans Went Skydiving – And Now We All Want To!
It takes a lot of balls to jump from a moving airplane – but to Chris Evans, it's no big deal.
Is anyone feeling the urge to do something crazy too?


What does Islam say about global warming? Is man causing global warming? Is it global warming, climate change, or tax revenue? What was the weather like at creation? What has been its history since then? What effect did Noah's flood have? What role does God have in weather? Does the Bible speak about future global warming? Does it matter if Polar Bears become extinct? A big picture of the world's weather from the Word of the Creator who was there – not the theories of men who weren't! Join world leader on Creation Research, John Mackay, as he looks at God's world and God's word and shows you the evidence from rocks and records.


text:
Q: Melt a matrix for a barplot I have a tibble with the following format:
ID       fragment1   value1   fragment2   value2   fragment3   value3
1        50          90       45          10       NA          NA
2        50          100      NA          NA       NA          NA

I want to make a barplot "fragment vs value" but I can't find the right way to modify the original matrix and I am struggling a bit to wrap my head around the "melting data" concept (by which I mean I don't completely understand what I should be aiming for).
Any help would be much appreciated.

A: reshape it on a list of the two column subsets, transpose, and barplot it.
reshape(dat, idvar='ID', varying=list(c(2, 4, 6), c(3, 5, 7)), direction='long') |>
  subset(select=3:4) |> t() |> barplot(beside=TRUE)

----
Update: Inspired by a comment from @onyambu, we can write the call a little golfy:
barplot(t(reshape(dat, -1, di='l', se='')[3:4]), be=T)

where
reshape(dat, -1, di='l', se='')
#     ID time fragment value id
# 1.1  1    1       50    90  1
# 2.1  2    1       50   100  2
# 1.2  1    2       45    10  1
# 2.2  2    2       NA    NA  2
# 1.3  1    3       NA    NA  1
# 2.3  2    3       NA    NA  2

Data:
dat <- structure(list(ID = 1:2, fragment1 = c(50L, 50L), value1 = c(90L,
100L), fragment2 = c(45L, NA), value2 = c(10L, NA), fragment3 = c(NA,
NA), value3 = c(NA, NA)), class = "data.frame", row.names = c(NA,
-2L))

A: Update: Thanks to @r2evans:
No need for rename_with:
library(dplyr)
library(tidyr)

pivot_longer(df, -ID, names_pattern = "(.*)([0-9]+)$", names_to = c(".value", "group"))

First answer:
Something like this:
library(dplyr)
library(tidyr)

df %>%
  rename_with(., ~sub("(\\d)$", "_\\1", .)) %>%
  pivot_longer(
    -ID,
    names_to = c(".value", "group"),
    values_to = "value",
    names_sep = "\\_"
  )

 ID group fragment value
  <int> <chr>    <int> <int>
1     1 1           50    90
2     1 2           45    10
3     1 3           NA    NA
4     2 1           50   100
5     2 2           NA    NA
6     2 3           NA    NA

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text:
Roma Lose Gervinho For Three Weeks Through Injury
Written by Peter Pedroncelli
Cote D'Ivoire star player Gervinho picked up an injury during their score draw with Equatorial Guinea in a friendly international at the weekend, and he will now miss three weeks as a result of a hamstring problem, according to his Italian club Roma.
The Elephants drew 1-1 against the 2015 Africa Cup of Nations (AFCON) hosts on Sunday evening, and on 37 minutes Gervinho was forced to leave the pitch with the injury.
Following the Equatorial Guinea match Gervinho immediately travelled back to Italy in order to do the necessary scans and tests to determine the extent of his injury, which has now been revealed as a Grade I hamstring strain.
An official statement from Roma revealed: "Medical tests carried out on Gervinho have revealed a Grade I hamstring strain. The forward, who will begin a recovery program tomorrow [Wednesday], is expected to be out of action for around three weeks."
With seven goals and four assists to his name during the course of 30 games thus far this season, the skilful Ivorian has been one of the reasons why the Giallorossi find themselves second in the Italian top flight, and he will certainly be missed by coach Rudi Garcia and his team-mates in the next three or four Serie A games.
Having been knocked out of the UEFA Europa League a couple of weeks ago by Fiorentina, the Romans will be focused on the league, and will hope to have their Africa Cup of Nations (AFCON) winner back in the first team as soon as he is able to recover.


PECOS, HAWTHORNE, 8188 Mens is rated 4.6 out of 5 by 5.
Stockyards, St. Paul, MN Photo courtesy of Minnesota Historical Society.
The 8188 is from our Pecos western boot collection. Hawthorne Muleskinner leather, brown nitrile cork sole, Goodyear welt construction and triple stitched quality. A Red Wing quality work boot in western styling.
Red Wing Shoe Company had an office in Dallas, Texas as early as 1923 to serve the unique market of ranchers, cowboys and oil drilling roughnecks in the region. At the time, most of these workers wore pull-on riding boots, often with decorative stitching, and Red Wing responded with one of its own in the 1930s. Our pull-on boot was given a new name, Pecos, after a town in Texas and it evolved into one of our most popular styles, thanks to its simple design, comfortable fit, and rugged good looks. Still made the same way with quality leathers in our factory in Red Wing, the Pecos is now seen on hardworking feet from coast to coast, both ends of the Mississippi, and everywhere in between. Call it a cowboy boot, with a Minnesota twist.
Rated 5 out of 5 by Michael80 from Wonderful classic boot Given as a Christmas present by my wife, these are my 5th pair of Red Wing shoes. No secret that I'm a big fan of the brand and only having worn them for a few days, these are my favourite so far. Followed closely by the 875 moc toe's. Very easy to get in and out of, especially when compared to the Engineer boots. These don't require breaking in in my experience as I've took some long walks with them without any issues. Loving the hawthorn leather and they look great with a faded pair of jeans. Bought these im Amsterdam and got these true to size and the fit seems pretty much perfect; comfortably loose and not too snug. Highly recommended and another great addition to my collection. If you're not willing to tug your jeans in, make sure to get some loose jeans however.
Rated 5 out of 5 by NorthernCowboy from Pair of Awesome, Rugged Boots Posting this review specifically for sizing recommendations, I normally wear a size 9 EE in Redwings 875's, I bought these in a size 9 as well, but found them to be WAY too small, I'm 9 EE on a Brannock device and these in a size 10 fit perfectly. Overall the boots are unbelievably well made, and the leather is very rugged and unlike any other leather I've had on boots in the past. I own a number of custom made boots and find the craftsmanship of these boots to be up to par with them.
Rated 4 out of 5 by RWFanatic5 from A western boot without the flash, but all the ruggedness. Thank you RW for releasing! Disclaimer: I am a RW super-fan so take this review with that in mind. This is my second pair of western boots I have ever purchased. I've been in the market for a few years now, however I haven't been able to find something I wanted to invest in. When Redwing released the 8188 recently, I knew these would be it. Truly is a beautiful boot and I cannot wait to see how it ages. On to the review... Negatives: since I live in Minnesota and it's cold/snowing six months out of the year I think RW could have done a better job making it an all-year boot, i.e.: cork sole = dangerous in icy and wet conditions, feet freeze in cold weather - this is my reasoning behind the 4 stars. My plan is to wear them until the winter and replace sole with a safer sole (probably something along the lines of what they have done with the new sole on the Iron Rangers). It would be a shame to put these boots away for the winter each year. I would be doing them a disservice if I only used them in spring, winter and fall. Don't expect these to break in right away - give them time. Run a bit narrow. Positives: good overall western work boot, they can do any job in summer, spring and fall, my other hawthorne leather boot ages incredibly well and are durable, comfortable, easy on/easy off. I would buy these again and again! Thank you RW for releasing these boots here!
Rated 5 out of 5 by LoveThisBoot from Great Everyday Wear Boot I bought this boot to wear during warmer months with lighter-weight jeans and t-shirts. Super comfortable and great casual styling. I love the lower height of this pull-on. Would love to see this in a mid-brown and charcoal/black, with the same distressed finish.
Rated 4 out of 5 by 44lasvegas from beautiful boot, opening a little wide These are fantastic books. Quality is unmatched. Super comfy right out of the box. Love the sole as well. The leather is a great color and has a really nice feel to it. My only problem is top of the boot is so wide that they bulge out with jeans over them. I wear Levis 501, which isn't even a skinny/slim jean and they still bulge some. It's not a huge deal, just wish the vamp was a little more narrow. Overall, very nice work Red Wing.


Researchers who run a lot of chromatin immunoprecipitation "ChIP" assays – maybe even your advisor – might subscribe to the idea that polyclonal antibodies perform better than monoclonal antibodies. But is that always actually true?
It's worth your time to understand the differences between the two in terms of antigen recognition and specificity, and dispel some myths.
Part two of a four-part series on Immunofluorescence. Check out our posts on Validation and Fixation and Permeabilization.
After months of hard work, your research has honed in on a hypothesis you can test with immunofluorescence (IF). You've chosen antibodies and performed pilot IF experiments (see The Importance of Validation), and the localization of the protein appears reasonable. But how can you be sure the IF data you've acquired represents real biological phenomena? We present two examples of experimental controls in this post.
Part 1 gave an overview on mass spectrometry-based proteomics. Now it's time to talk about how this strategy can be used to identify peptides with post-translational modifications (PTM) from a complex biological sample.
Part 1 and part 2 introduced mass spectrometry-based proteomic methods, like PTMScan®, for the study of post-translational modifications (PTMs). In the final part of this series you can see how PTMScan can be applied in translational research.
After sequencing of the human genome was complete, it was time to roll up our sleeves and get started on the daunting task of unraveling the complexity of the proteome. Thus the era of proteomics, the study of the function of all expressed proteins, was born. This task is especially complicated because unlike the human genome, which is largely static in every cell, the proteome is different between say a liver cell and a brain cell, or between a healthy cell and a cancerous cell, or even between an individual cell at the different stages of development. To address this challenge the Human Proteome Project was founded. Its mission is to characterize all human genes by generating a map of the protein based molecular architecture of the body. In this way, it will become a resource to help elucidate the biological and molecular function of genes and facilitate the advanced diagnosis and treatment of disease.
Simplifying proteomics part 1 introduced mass spectrometry-based proteomics for profiling post-translational modifications (PTMs). Part 2 explained how you can go fishing for low abundance PTM peptides from a complex mixture using PTMScan.


text:
By Timothy N. Noel on January 11, 2022 Farmer world
NEW YORK (AP) – Rachel Balkovec became the first woman hired to manage a minor league affiliate of a Major League Baseball team when she was promoted Tuesday by the New York Yankees to boss of the Low In Tampa Tarpons.
The 34-year-old joined the Yankees organization as a batting coach in 2019, making her the first woman to hold that full-time position in affiliate baseball. She secured her first position in professional ball with the St. Louis Cardinals as a minor league strength and conditioning coach in 2012.
Balkovec, a former softball receiver in Creighton and New Mexico, moved from the Cardinals to the Houston Astros in 2016. She was hired as the Strength and Conditioning Coordinator for Latin America, a position for which she learned spanish, then developed into strength and conditioning. coach at Double-A Corpus Christi.
She briefly left baseball in 2018 to pursue a second master's degree at the University of Vrije in the Netherlands, where she also worked with the country's national baseball and softball teams. She then worked for Driveline Baseball, a data center that trained many major leagues, before being hired by New York.
"I see my background as an advantage," she told The Associated Press in 2019. "I probably had to do a lot more than maybe a male counterpart, but I like it because I'm so much better. prepared for any challenges I may encounter. "