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Scientists Have Finally Mapped the Entire Human Genome
The final release of the Human Genome Project in 2003 left 8 percent of the genome behind. Now, a grassroots effort has closed the gaps.
By Connor LynchMay 10, 2022 9:00 PM
(Credit: ANA VANESA GARCIA NARANJO/Shutterstock)
A job well begun is half done, according to Aristotle. The Human Genome Project, which announced its final release in 2003, was certainly a solid start in surveying our hereditary instructions — and well over half finished. Researchers mapped 92 percent of a sample human genome, representing nearly 3 billion base pairs. It established a blueprint for nearly 20 years of research by allowing other teams to highlight variations in genomes between humans. This work has since expanded to other animals, along with plants and even microbes.
While researchers were limited by the era's technology, the massive team of nearly 3,000 people managed to map the euchromatic regions of DNA, which are relatively gene-rich and loose sections of chromosomes. These were easier and (theoretically) more valuable to map compared to the heterochromatic regions, which were beyond their grasp.
That is, until now. A recent grassroots effort led by scientists at Telomere-to-Telomere Consortium has successfully filled in those missing gaps, as reported in a March Science paper. Their results could prove just as revolutionary as the original Human Project, according to Consortium co-leads Adam Phillipy and Karen Miga.
Tackling the Trickiest Targets
The most recent project identified three main mapping targets for its sample genome: centromeric satellite arrays; recent segmental duplications; and the short arms of the five acrocentric chromosomes (chromosomes that aren't cut evenly in half). Their sequence has not only corrected errors in prior references but revealed that these absent sections may be far more significant than previously imagined — they may play a much larger role in our genome, and in understanding diseases like cancer, than previously expected. "I think we're going to find there's more variation in that 8 percent than in the 92 percent we've been looking at," Phillipy says.
These chunks of the genome weren't previously surveyed because they were difficult to map and weren't thought to contain genes. Yet we now know that these regions "present some of the most highly variable sequences in our human species," Miga says. Over 2,000 gene predictions have come out of the latest project, and nearly 100 of those are expected to code for proteins, unlike so-called junk DNA.
The 8 percent of the genome that the researchers from the Telomere-to-Telomere Consortium filled in is composed of repetitive sequences — either with patterns of base pairs that repeat one after another, or whole sections that were essentially copied and pasted. However, this portion is still crucial. "As a field, we kind of collectively gaslit each other into thinking that this 8 percent was junk," Phillipy says. "If you were to delete this 8 percent from any genome, you would not live. That's a pretty easy definition that it's doing something useful."
One interesting feature: the centromeres, which play a major role in ensuring proper cell division. These arrangements of non-gene regions can give us insight into errors in cell division such as cancer, Miga adds.
A New Era of Personalized Medicine
While mapping an additional 8 percent of a genome sounds more like a clean-up job than a paradigm shift, the researchers agree that nothing could be further from the truth. "The regions we were missing are really specialized regions that we've never been able to study at this depth," Miga says.
The first Human Genome Project was considered revolutionary and ushered in the emerging field of personalized medicine. Now, the latest iteration reflects a major change in mapping technology and how scientists apply it. While Phillipy and colleagues are currently working out the kinks, they expect major results.
"There'll be a moment where we create a new standard of genetics and genomics, where every genome will need to be at this level," Miga says. "And the amount of new info we find will be incredible."
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NEW WILMINGTON, Pa. – The Westminster College football team will a bid to play in the Clayton Chapman Bowl to Burry Stadium on Saturday, Nov. 17 at 12 p.m. Westminster College will host Eastern College Athletic Conference (ECAC) championship game for the third time in program history.
The Titans (7-3) face Wesley College (6-4), located in Dover, Delaware, in post-season Division III championship action.
You can listen to the game live on Titan Radio (on the air and streaming online). You can also watch on WCN on local cable television and and streaming on wclive.com.
Westminster won both of its ECAC James Lynah Bowl games in back-to-back years. The Titans won, 33-6, over Utica College in 2016 and, 42-21, over St. John Fisher College in 2015.
Saturday's meeting will be the first-ever between the Wolverines and the Titans. Wesley is part of the New Jersey Athletic Conference (NJAC). Wesley is 6-4 overall and finished 5-4 in the NJAC.
This is the first time Westminster has hosted a postseason game since 1994 when the Titans played Lambuth University (TN) in the National Association of Intercollegiate Athletics (NAIA) Division II National Championship Semifinals. Westminster won, 46-6, and went on to win its sixth national title with a 27-7 victory over Pacific Lutheran University (WA).
The Titans finished tied for second in the Presidents' Athletic Conference (PAC) with a 7-2 record.


The college was founded way back in 1964 in Amaravati village of Howrah district some 75 kms away from Kolkata in the close vicinity of Gadiarah – well known tourist spot of southern West Bengal.
Late Murari Mohan Manna – the visionary pathfinder – being identified with the common man's right to enlightenment and appreciating the necessity of spreading the lights of education to the thousands of underprivileged families for their empowerment, founded the college with whatever resources he was endowed with. The genesis of the college was modest, as it offered general stream courses in humanities, science and commerce, but consolidating on the foundation of vision for growth, the curriculum bouquet soon started enriching itself to impart honours curriculum. In many of the subjects and today the college has 18 departments of which 13 departments impart honours curriculum.
The college being the only one of its kind within the radial periphery of 25 kms, has delivered the need for higher education to a vast section of the underprivileged society for the last 50 years through the unquestioned commitment of the teachers and the members of the non-teaching staff.
Higher Education across the globe is witnessing widespread changes. The core element of such changes is to make higher education more and more befitting to the different dimensions of transformation taking place in the nature and functioning of economy in general and business in particular.
In face of such changes that has come during the last five to ten years and with many more changes to come in the coming years perhaps at an increasingly greater pace, institutes of higher education are to change – a change that empowers both the educators as well as the learners so that higher education institutes become relevant to all its stakeholders which essentially lies in its ability to link people with the new age, helping them to identify with the emerging realities, motivating them to accept the change and enable them to be self-learners.
The Quality Awareness cell has been set up by the Principal in consultation with the teachers during the Teachers' Council Meeting held on January 20, 2009. The decision to set up such a cell got further approved by the Governing Body of the college during its meeting held on March 20, 2009. Our college has been accredited by the National Assessment and Accreditation Council (NAAC) for a period of five years at 'B' Grade valid from 08.01.2011.
The Quality Cell has been set up with the objective of preparing the ground for setting up of the IQAC during the post assessment stage. The IQAC has already been set up in the meeting of the Teachers' Council dated 10.05.2011.
It is for this reason we feel we need to draw an Action Plan for the future realization of which, however, is dependent on fulfillment of several external constraints.
For years, the interactions between educators and learners were less transparent as practice of teaching in an academia remained a closed-room affair while transparency remained less pronounced.
The need of the hour is planned and systematic delivery of lessons with large emphasis on applied content on one hand and transparency on the other. Teachers in each faculty will be required to build modular curriculum which renders a fairly high degree of transparency about the course contents and goes a long way in shaping a profound conception and understanding about the subject. The rigorous use of computer-web technology is expected to create lasting impressions on the learners' mind and is therefore more effective.
Yet another area, which requires reorientation of thinking, is exploring greater interaction among teachers [intra and inter department from within and outside the institutions] often along inter disciplinary lines so that seminars and exchange lectures are arranged which promotes the healthy practices of academic interactions.
With the winds privatization gaining momentum, state is no longer the principal employer of the educated youth in the country. The hard reality is that majority of employment opportunities now are in the private sector and this sector employs only those who possess skills and competencies required by it which are continually changing to keep pace with its global competitors. Looking from this perspective HEIs these days are expected to provide support to the students beyond core learning with an obvious thrust towards career building and the curriculum must be tailor-made to the requirements of the private sector so that HEIs can function as effective supply chain to the corporate sector.
This requires the HEIs to include value added courses like Communicative English, Basic Computer Training etc. the college envisages performing the function of enrichment of students by making them learn.
To rise above the narrow domain of gender, caste, creed, religion and to enrich human life the college has the vision to introduce NCC Training, Women's Empowerment Cell etc.


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Cherryville breaks out for 14-5 win, 2-0 lead in series
DENVER – After losing five straight and nine of its last 13 games of the regular season, Cherryville Post 100 sought a change when the postseason began.
Whether it's a gnome dressed up on the team bench or the red uniforms the team is now wearing, Post 100 has been a different team through two games of the playoffs.
On Wednesday night, Cherryville rallied in the late innings for a 14-5 victory over the Lincoln County Cardinals that gives Post 100 a 2-0 lead in their best-of-five North Carolina Area IV first round playoff series.
Cherryville (18-11) goes for the series clincher Thursday night at 7 p.m. at Fraley Field. Lincoln County fell to 7-13.
"We knew we had to do something different and so far it's working," said Cherryville Bobby Reynolds, who is wearing a new Under Armour red pullover. "Tonight was a tough game for us because we know how good their pitcher was."
That pitcher, Justin Norton, helped the Cardinals beat Cherryville three games to two in last year's Area IV semifinal series. And Norton, who just completed his freshman year at Catawba Valley Community College, retired 14 of 16 batters in the middle of Wednesday's game before Post 100 was able to outlast him.
Cherryville scored five in the seventh inning to chase Norton after 6 1-3 innings and later struck for eight in the ninth after Lincoln County had gotten within 6-5.
"We just kind of hung in there on him," Reynolds said of facing Norton.
RBI hits by A.J. Cook and Brandon Alexander highlighted the seventh inning rally that also took advantage of one Cardinals fielding error and one walk.
In the ninth, Hunter Jackson had a two-run double and Brett Huff a two-run home run.
The result made a winner of starter Dillon Harris, who yielded five hits and five walks in six innings. Grey Goines got the last six outs for the save.
Chandler Jenkins' three hits lead Cherryville's 14-hit offense. Cook, Alexander, Jackson and Josh Beam added two hits apiece.
Nathaniel Scoggins had three of Lincoln County's 10 hits. Nick Savoie added two hits and Clay Hodges, playing in his first game of the season after recovering from an injury, had a RBI single to plate the Cardinals' first run.
"We're just trying to play better," Reynolds said. "We didn't finish the season the way we wanted to, but the playoffs are a new season."

redpajama_set_name: RedPajamaCommonCrawl


A little extra dopeness from The Regiment. This remix features all new lyrical flavors from the duo and an extra verse from Boog Brown. If you are liking this then you should be copping that album, The Panic Button.


The couple wed among family and friends in New Orleans.
The Assassination of Gianni Versace: American Crime Story actor, 32, married longtime love Mia Swier, 33, on Saturday.
Criss and Swier said "I do" in New Orleans as their loved ones and friends looked on.
The star-studded guest list included fellow Glee alums Lea Michele, John Stamos, Chord Overstreet and Harry Shum Jr.
The happy couple, who have been together for around eight years, announced their engagement in January 2018, though Criss later admitted they'd been engaged for a bit before they made the announcement.
Related: Actor Darren Criss Is Engaged!
"Mia and I have had seven and a half years of fun, wacky, wonderful, CRAZY adventures together," the Glee star wrote at the time alongside a photo of the pair. "And I'm happy to announce that we're kicking those adventures up a notch. We're goin for it. To boldly go where neither of us have gone before. Engage."
Criss later told Esquire his proposal "was a long time coming."
Swier has worked for Fox and Showtime and attended New York University's Steinhardt School of Media Studies and Television Production.
Criss has been enjoying a successful awards season, picking up an Emmy, Golden Globe and Screen Actors Guild award for playing killer Andrew Cunanan in American Crime Story.
He gave a sweet shout-out to Swier in his Globes acceptance speech, thanking her for her "undying love and patience."
This post originally appeared on People.com by Breanne L. Heldman.


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Romanian boxer Lucian Bute: I will fight in Romania on July 9
Vineri, 8 aprilie 2011, 12:32 English | Top News
Lucian Bute and his fans' wish, so see the Romanian world boxing champion fight in Romania will come true on July 9th when Bute will defend his belt. Interbox and IBF will decide on the adversary I will face in Romania, what is important is that I will get to fight in my country, Bute said.
Many Romanians want to see me box live in Romania and for me it is an honour and a dream to fight in the country, Bute said. He said that by coming in Romania to fight, he wants to award all those who have supported him so far. Romania is my home, it's where my heart is, Bute said.
Lucian Bute has been invincible in 28 games of which 23 victories he obtained through knock out. The Romania won the title in October 2007 in the match against Columbian Alejandro Berrio. So far Bute defended his title seven times, the most recent in the game against Irish Brian Magee.


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Blog home Destinations Ibiza Month: Ibiza Closing Parties 2014
Ibiza Month: Ibiza Closing Parties 2014
Ibiza's closing parties are the stuff of legend, where top-billing DJs have one last hurrah, playing the tunes that got dancefloors thronging throughout the summer and ensuring you end on a high that should carry you through the coming winter.
With the exception of Pacha, which stays open year-round, Ibiza's big clubs and promoters pull down the shutters by October, so many of the season's biggest bashes are the closing parties thrown throughout September and early October. Many clubbers time their holidays around them and some clubs have even been known to grant free admission once it gets to a suitably messy hour.
Go big before you go home, with our pick of Ibiza closing parties 2014.
Gatecrasher Ibiza
Wednesday 31 August, Privilege
The return of day-glo trance and progressive house behemoth Gatecrasher to Ibiza has been one of the big talking points of this season and after what's sure to be a stonking season, they're intending to go out with a bang. Global dance music pioneer and original Ministry of Sound resident Paul Oakenfold tops the bill, with sets from the hyperactive Dash Berlin, who's frequently name-checked as EDM's 'fastest rising star' and the ever-inventive Marco V, a regular fixture in DJ Magazine's annual top 50 list, who'll be bringing his innovative multimedia show The T.A.O Sound to the world's biggest club.
Together Closing Party
Tuesday 23 September, Amnesia
Together has carved out a niche for itself this year with some diverse line ups and ferocious bass-heavy mayhem, thanks to the presence of celebrity producer remix duo Chase and Status as residents. Taking things up a notch on the Terrace is Fatboy Slim, whose anthem Eat, Sleep, Rave, Repeat has become a mantra for many a diehard party animal, and with further special guests to be announced, this promises to be one epic swansong.
Cream Closing Party Part 2
Thursday 25 September, Amnesia
Never ones to do things by halves, Cream's annual send-off is so colossal they had to split it in two, as they celebrate 20 years on the white island and their status as Britain's longest running club night. Dutch trance deity Paul van Djyk is the master of ceremonies here, and with the likes of Benny Benassi and Laidback Luke on the Mixmag Terrace and Sneijder and Ben Gold in the main room, it's sure to be a belter.
Lost in Ibiza Boat Party
Wednesday 24 September, San Antonio
Ibiza's boat parties have made titanic waves in recent years and Lost In Ibiza promises to delight its loyal underground house following with this mammoth 14-hour party. Kicking things off with a 3 hour sunset cruise are Sante and Sidney Charles rocking the thunderous Funktion One Soundsystem, before decamping at midnight to Paradise Closing at DC10, the no-nonsense stalwart venue for the deep house crowd who like to hurtle along until 6am.
F*** Me I'm Famous Closing Party
Thursday 2 October, Pacha
Saving the best to last is the final outing of French superstar DJ extraordinaire David Guetta's Thursday night shindig, which regularly brings the streets outside Pacha to a standstill. There are always queues round the block for this party, where 'everyone who's anyone' clamours for a ticket – this is one closing party where booking a luxury VIP table well in advance can be a shrewd move.
Attending any closing parties yourself this year? Perhaps you're an Ibiza veteran and want to share some tips with this summer's Balearic holiday-makers? Share your thoughts in the comments below!
Read previous How To Guide: Turn Data Roaming off on Your Phone
Read next Ibiza month: the "other" side of Ibiza
Samuel Natoli
Sam Natoli is a keen travel blogger, based in London but originally from South Africa. He blogs for Holiday Hypermarket about travelling in out-of-the-way places, including the Gambia, the Med and anywhere else that catches his eye.
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Exploratorium Reborn: Inside San Francisco's New Innovation Shrine
Alice Truong
When San Francisco's Exploratorium began to outgrow its 100,000-square-foot campus at the Palace of Fine Arts—where it had been since its founding in 1969—it looked for a new home, eventually settling on the city's Embarcadero, a stone's throw from downtown.
With its relocation, the Exploratorium took the opportunity to design a world-class science and technology institution with a goal of becoming the world's largest net-zero energy museum. Three months after it shuttered its old doors, and nearly a decade of planning later, the Exploratorium is set to re-open on Pier 15 next week.
The new Exploratorium officially opens on April 17th, but we got a sneak preview of its new space and exhibits. This is what a 21st century museum looks like: a structure every bit as evolved as its contents.
At opening, a quarter of the 600 exhibits will be brand new. Notably, some of these additions highlight the Exploratorium's investment in green technologies, putting on display otherwise quiet infrastructure. The floors, for example, play an integral part of a unique HVAC system. Its embedded pipes circulate 73,800 gallons of bay water each hour to heat and cool the building. The roof, meanwhile, holds the distinction of being the city's second largest solar roof—first, if you ignore utility companies.
There's obviously so much to explore, but here are some of our favorite architectural touches from San Francisco's newest informational mecca.
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The New Digs
The Exploratorium's new home on Pier 15 will more than triple its real estate with 330,000 square feet. To ensure the museum won't outgrow its space, Pier 17 (not pictured) will provide another 2.5 acres for future expansion. Dennis Bartels, director of the Exploratorium, said the previous location in the Marina district was "a bit dark, a bit dusty and a little isolated," in stark contrast to the Embarcadero, which he called "the front porch of San Francisco."
A Light Show Celebration
To commemorate the Exploratorium's opening, Emergence, a video installation by Obscura Digital, will display on Pier 15's facade the evenings of April 17 and 18. Combine that with the Bay Bridge LEDs, and the Embarcadero has some fun light shows ahead. Rendering: Obscura Digital
Up On the (Solar) Roof
The high-efficiency SunPower photovoltaics, estimated to cost $1 million after state and federal grants, is expected to generate enough energy to sustain the museum's operations, drawing from the grid when necessary during the evenings and winter months, and giving back to the city during long summer and fall days. Over the course of the year, this is said to equal out to net-zero emissions, and the museum expects the savings to pay for the system within a decade. A display in the bulkhead lobby will show visitors the roof's real-time performance.
Keeping Cool, Keeping Warm
For temperature control, the Bay Water Heating and Cooling System takes advantage of the bay, which fluctuates between 55 and 65 degrees seasonally, using it as a heat source and sink. See the lines at the bottom of the frame? They help the windows reflect light and keep the interior cool.
The Bay Water Heating and Cooling System filters water in three stages to remove sea life and bacteria before pumping it through titanium heat exchangers and into 25 miles of tubing that runs through the concrete floors.
Workshop Stop
When Frank Oppenheimer created the Exploratorium, he wanted the workshop to be prominently on display. "He wanted you to smell the oil," said Ron Hipschman, one of the museum's science educators. "The ghost of Frank is always with us."
Rehab and Reno
Much renovation was needed to make Piers 15 and 17 habitable, including the repair of 4,000 dilapidated underwater pilings that serve as the buildings' foundation.
Smaller Spaces, More Control
Unlike the Palace of Fine Arts' cavernous interior, the new location breaks up the space into indoor galleries (pictured: Central Gallery). Instead of inefficiently heating or cooling an entire building, the museum can now fine tune the temperature for these galleries.
Fog Town, USA
San Francisco is notorious for its fog. Since this part of town isn't usually as hard hit, the Exploratorium is creating its own with the installation Fog Bridge by artist-in-residence Fujiko Nakaya. Nakaya, whose fog sculpture was a hit at the Osaka Expo in 1970, collaborated with a cloud physicist to create a chemical-free fog for this exhibit.
Fun fact: Pi Day was established in 1988 at the Exploratorium. This benchmark plays homage to the annual celebration on March 14.
Touch and Go
One of the Exploratorium's most popular exhibits, the Tactile Dome won't open until the summer. The dome creates a pitch black environment that requires visitors to navigate darkness (and passages lined with strange textures) relying solely on their sense of touch.
Images: Alice Truong
Alice Truong is a freelance writer and photographer in San Francisco. You can follow her on Twitter here.


The president and CEO of Discovery Communications will discuss the global programming environment as well as the company's recent international acquisitions and strategic partnerships during a keynote session.
Discovery Communications' president and CEO David Zaslav is coming to Cannes.
Zaslav will present a keynote address at MIPTV on Tuesday, April 9, as part of the market and conference's Media Mastermind series.
Organizers say the Discovery topper will discuss the global programming environment as well as the company's recent international acquisitions and strategic partnerships during his session.
Late last year, the global non-fiction media company announced plans to buy ProSiebenSat1′s SBS Nordic operations, a deal valued at approximately US$1.7 billion. At roughly the same time, Discovery Communications confirmed that it had entered a strategic partnership with France's TF1, which would see the U.S. company take a 20% minority interest in the Eurosport group, which could potentially raise to 51% in two years' time.
The company's flagship channel, Discovery Channel, also recently announced plans to move into scripted programming with the upcoming Klondike (w/t) project, to be produced by Scott Free Productions and eOne Television.
MIPTV runs from April 8-11.


We all like to assume that the applications we work on are getting better each and every time we sit down in front of the IDE and start banging out code for it. But how do you really know? Code metrics help with that. You can see how coupled your classes are, the cyclomatic complexity, and that sort of thing. As you go, you can look at the historical stats vs the current stats and (hopefully) see an improvement, which suggests greater maintainability down the line. Great.
But what about personal metrics…?
Despite how quickly technologies change, it's easy to grow complacent and for skills to stagnate.
So how do we detect these weak spots and build up our resilience and proficiency in our skills?
In a team setting, I've helped increase our collective skills by implementing what I've called "Developer Fight Club". It might be a simple algorithm or a full-fledged application, but the end result is someone will be deemed the winner and the rest of the participants are able to learn from their mistakes (or the successes of others) in order to perform better next time.
On a personal level, though, it feels a bit more difficult… Over the years, I've used all sorts of goals and metrics. Number of tickets closed, average duration between work-order assignment and resolution, frequency of blog posts on this site, number of development books I've read each month, etc.
There are definitely large gaps and flaws in the information you can get from any one of those values, but I think if they are looked at collectively, it can at least give me a more objective look at how engaged I am, more than I might be aware of on my own.


text:
Q: Send csv with airflow Hi i'm trying to send a file with airflow (composer) csv stored in gcp storage but i can't attach it.
I get the error "No such file or directory: 'gs://bucket-test/test.csv'"
the mail is sent correctly if I do not attach a file.
another question is: can I create a csv without saving it to storage? and send it directly
output_file = 'gs://bucket-test/test.csv'

email_summary = email_operator.EmailOperator(
    task_id='email_summary',
    to=['test@gmail.com'],
    subject='Sample email',
    html_content="""
    test_01.
    """,
    files=[output_file])

A: airflow cannot directly access the storage bucket, so the file must first be downloaded to the local file system
download_file = GCSToLocalFilesystemOperator(
    task_id="download_file",
    object_name='test.csv',
    bucket='bucket-test',
    filename='/home/airflow/gcs/data/test.csv',
)

redpajama_set_name: RedPajamaStackExchange


Other than its lack of in-house wifi (which we solved by bringing our own), we were pretty happy with our hotel room in Menton, which was Hôtel Club Le Balmoral. The hotel's location, I think I noted, was fantastic: very central, facing the beach on one side. The room and bathroom was a good size (for Europe), and—a feature I find annoyingly rare in hotels—was furnished with well-placed desks and shelves and full-length mirrors, such that we could set up to work on our tablets, easily arrange the toiletry items, and confirm that in fact my outdoor clothing really didn't match from head to toe. 🙂 The room temperature was a little bit of an issue until we remembered that with European hotels, you can actually open the window (no screens!), and the natural bit of air conditioning did the trick there.
So the only problem was the food.
It wasn't all dire. They certainly used a good supplier of food ingredients such that breakfast buffet, which we had every day, was very good: delicious croissant, very fresh fruit salad, nice cheese and ham. Similarly, the cheese course that was always included with dinner featured some wonderful French cheeses. And whoever did the desserts had some talent; those were always nice—lemon meringue pie, ile flottante, crème caramel.
But the cooking was a problem. Overcooked, dry fish. Under-seasoned soup. Mushy, overbreaded shrimp. Spring rolls so tough you could barely cut through them. Oy. They were somewhat better with meat—the lamb tangine we had one night was probably the most successful of the week's entrees—but it was definitely disappointing to be in France and not be able to count on getting great food.
Fortunately, the restaurant meals did make up for that, to some degree. Best of the lot was Table d'Oc, which I'd read about before leaving, and which ended up being very close to the hotel. It was a small, funky, fairly casual place with a nautical theme, despite not being particularly focused on seafood.
Prices were quite reasonable, offering three-course meals for 21 Euros (about 32 dollars).
He found it some of the best cold foie gras he'd had, but nevertheless managed to leave some of the container for others.
As a main course, I had more duck, sliced and served in a pepper sauce. That came with carrots, long green beans, and scalloped potatoes. All very good. Jean had the pork and morels, which tasted amazing, and the same veg as I.
Except for an unusually long wait for the bill, it was quite a lovely evening out.
Another pretty successful meal was at Le Cirke, which I read about in The Guardian. This was a somewhat more expensive seafood place. Jean started with a seafood soup, while I had an octopus and white bean salad. Then we shared the paella, which contained only seafood—no chicken, no sausage. All well-prepared and tasty.
Lunch most days was on the trail, so was basically unexciting sandwiches and granola bars. But in Nice on our free day, we did have lunch at a bistro, enjoying some pasta in a pot .
Later that day we joined much of the rest of the group to see what they were doing for dinner, which turned out not to be the greatest idea. I thought the group of 8 might split into 2 or 3 smaller groups headed for different locales, but instead everyone took off together, which of course made it more difficult to find a place that could accommodate us all. One place claimed to be able to, by putting tables together outside, but then he proceeded to basically ignore us for some time: no menus, no drink orders, while attended to other tables and other people arriving. Most of the group got kind of offended by this and decided to leave; Jean, I, and another lady decided to stay.
Our "congenial" host than got a bit irate about the departure and started barking at us to change tables, whereupon Jean pretty much wanted to leave, also. I was kind with him on that, but the lady we were with didn't seem to catch it (admittedly, she didn't have as many years experience as I at reading Jean body language), and persisted in ordering us some wine. So, we ended up staying.
The service did get civil, if never quite friendly (this would be a rare time you'd wish they tipped in France, so you could not leave one). But, upside: The food was really good. Jean had gnocchi with gorgonzola, followed by duck with morels. I had grilled calamari with arugula, followed by risotto with a half lobster. And it was a pleasant evening in terms of the company.
But we would never go back to that restaurant again.
Categories: Food, Travel | Tags: Europe, food, photography, restaurants, travel, wine | Permalink.
I've been admiring your clothes in all these restaurant pix! Really cute!


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Interleukin-13 (IL-13)in autoimmune rheumatic diseases: relationship with autoantibody profile
T Rinaldi1,
A Spadaro1,
V Riccieri1,
E Taccari1 &
G Valesini1
The production of rheumatoid factor (RF) and antinuclear antibody by B-cells could depend on different cytokines action. We evaluated IL-13 serum levels in 230 patients with autoimmune rheumatic diseases including rheumatoid arthritis (RA) [M/F=22/62; mean age=55.2 (25-76) yrs; mean disease duration = 116 (5-605) months], SLE [M/F=17/97; mean age=38.3 (15-70) yrs; mean disease duration = 77 (1-456) months], Sjögren's syndrome (SS) [M/F=2/50; mean age = 55.2 (26-81) yrs; mean disease duration = 82 (3-540) months], and systemic sclerosis (ScS) [M/F = 1/31; mean age=50.6 (20-73) yrs; mean disease duration = 113 (12-276) months], in order to investigate the relationship of this cytokine with the autoantibody profile.
Serum levels of IL-13 (pg/ml) were significantly increased in patients with RA (P < 0.00003), with SLE (P < 0.03), with SS (P < 0.0007), with ScS (P < 0.025) as compared to controls. IL-13 serum levels correlated with those of RF in RA (P < 0.00001), SLE (P < 0.003) and ScS (P < 0.03). IL-13 levels were higher in RA (P < 0.0002), SLE (P < 0.004) and ScS (P < 0.05) patients with RF than patients without RF. SS patients with anti-SSA/Ro antibodies had significantly higher IL-13 levels than SS patients without this autoantibody (P < 0.036). No statistically significative correlation was found between IL-13 levels and any other antinuclear autoantibody or total immunoglobulin levels or main clinical features of each disease.
This study suggests that IL-13 may be involved in the pathogenesis of autoimmune rheumatic diseases, with a relevant role on RF production. In SS, the lack of correlation between IL-13 and RF is probably due to the peculiar characteristics of this antibody in the disease. We can conclude that the mechanisms involved in RF synthesis recognise different pathways depending on the underlying autoimmune disease.
Dipartimento di Terapia Medica, Unità di Reumatologia, Università "La Sapienza", Rome, Italy
T Rinaldi
, A Spadaro
, V Riccieri
, E Taccari
& G Valesini
Search for T Rinaldi in:
Search for A Spadaro in:
Search for V Riccieri in:
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Search for G Valesini in:
Rinaldi, T., Spadaro, A., Riccieri, V. et al. Interleukin-13 (IL-13)in autoimmune rheumatic diseases: relationship with autoantibody profile. Arthritis Res Ther 3, P022 (2001) doi:10.1186/ar191
Immunoglobulin Level
Main Clinical Feature


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Electrifying news from Bentley
August 15, 2021 Macfivenews Motoring news Leave a comment
New V6 Hybrid Flying Spur hits roads
Bentley Mulliner has announced the new Flying Spur Mulliner – the ultimate in four-door luxury Grand Touring and Mulliner's first electrified Bentley. Whether enjoying the technically advanced V6 Hybrid powertrain, the emotional V8 or endless waves of torque from the W12, customers will still benefit from the exquisite detailing offered by the latest Mulliner product.
Revealed at the prestigious Monterey Car Week in California, the elegantly appointed sedan sits at the pinnacle of the Flying Spur family, combining the very finest in modern craftsmanship and breath-taking luxury.
The most luxurious Flying Spur to date has been created and developed by Bentley Mulliner and designed, engineered and handcrafted in Great Britain. Taking its place as the flagship of the Bentley range, the new Flying Spur Mulliner will appeal to customers who desire an even greater focus on elegant details.
Beautifully appointed detailing includes exclusive Mulliner 22-inch wheels, in a grey painted and polished finish, with self-levelling wheel caps that remain upright as the wheels rotate. A "Double Diamond" front grille and chrome front lower grille are matched by bespoke Mulliner branded wing vents and Satin Silver painted mirror caps. The iconic Bentley Flying B is electronically deployed and illuminated, while the Flying Spur Mulliner also features jewel fuel and oil caps.
Mulliner illuminated outer treadplates and deep-pile Mulliner overmats welcome passengers inside the ultimate Flying Spur cabin, which offers a Mulliner curation of eight custom-made, three-colour combinations. The sumptuously trimmed cockpit is complemented by accent colour piping and unique Mulliner embroidery to the hand-stitched seats.
An example of one of the curated interiors – Ascot – is a combination of Imperial Blue leather to the instrument panel, door trims and headlining while a light tan leather called Camel, emphasises the style of the seats. White micro-piping, embroidery and accent line combines a third colour into the unique Mulliner interior.
Further combinations such as Flare and Sirius add bolder combinations including Hotspur and Beluga, and Linen and Brunel both with a silver accent.
The Mulliner Driving Specification is fitted as standard, bringing the "Diamond-in-Diamond" quilting to the seats, and three-dimensional leather to the doors. Contrast seat piping matches the accent that surrounds the occupants from the centre console, around the instrument panel and finishes beneath the door waistrail, highlighting the Bentley B chrome inlays.
The luxurious Diamond-in-Diamond interior quilting involves an embroidery process that alone took 18 months to develop. Each diamond contains exactly 712 individual stitches – each one aligned to the exact centre of the diamond it creates.
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Bentley Mulliner
Bentley Mulliner is Bentley's highly-acclaimed, bespoke commissioning division and the oldest coachbuilder in the world. Synonymous with luxury, the new Flying Spur Mulliner is just the third member of the newly-created Bentley Mulliner Collections family alongside the sublime Continental GT and Continental GT Convertible.
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An experienced team, supported by in-house engineers and designers at Bentley headquarters in Crewe, prides itself on a long history of fulfilling the desires and demands of every Mulliner customer.
Bentleyelectric
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Tag Archives: extinction
Barry Lopez brought us I, Snow Leopard
December 31, 2020 By Valorie Grace Hallinan in Books, Ecology, Literature in Translation, Nature, Nonfiction, Poetry, Sustainable Living, Writing Tags: Barry Lopez, China, Chinese literature, extinction, I Snow Leopard, Jidi Majia, poems, snow leopards, wildlife	3 Comments
Photo by Tambako The Jaguar Creative Commons Attribution-Share Alike 2.0 Generic license
"I, SNOW LEOPARD is both a lyric and an elegy. It is easy to imagine its lines being loudly hailed in whatever country the poem finds itself in. It's publication comes at a time when people everywhere have begun to wonder what a voice like this, suppressed for centuries, wishes to say now, in this moment when the Snow Leopard's human brothers and sisters find themselves side by side with him. Imperiled." Barry Lopez
Happy New Year, everyone! In honor of Barry' Lopez's passing on Christmas Day, I'm reposting my previous Books Can Save a Life writings about him. I wrote the following post on April 16, 2016, after Lopez visited Rochester, NY:
Barry Lopez came to Rochester this week to receive "The Art of Fact" award for literary nonfiction presented by The College at Brockport Writers Forum and M&T Bank.
If you've been following my blog, you know that Barry Lopez is one of my heroes, not quite at the level of Pope Francis and the Dalai Lama, but close. (See my blog's header quote.)
Lopez is one of the very best nature writers, and if you love animals and wildlife, you'll love his nonfiction books, essays, and short stories. He has travelled to 90 countries and has a tremendous respect for the animal world and the many indigenous peoples he's come to know.
Lopez came to Rochester to receive his award and to deliver to us the poem "I, Snow Leopard" by Jidi Majia.
I wasn't familiar with either the poet or the poem, but Lopez said that when he found out "I, Snow Leopard" had been published in Asia and Europe, but not in the United States, he had to set things right.
He felt that it was vitally important that the American people hear the words of the snow leopard in this poem. So he saw to its publication here, and wrote the foreword to the English edition.
Jidi Majia, a member of the indigenous Nuosu (Yi) people who live in the mountains of southwestern China, has won numerous literary awards. As far as I could tell from what I found online, few of his poems have been translated into English.
Majia's poem is written in the words of a snow leopard, which is viewed by the Nuosu as a wisdom keeper, a being with "biological authority," according to Lopez.
He told us that when he first began traveling the world and exploring, in his thirties, he viewed wild animals in an amateur, superficial, childlike way, until he learned to embrace the much more refined view held by native peoples.
A poem is a door anyone can walk through, Lopez said, and this poem is the mysterious and elusive snow leopard's expression of grief and a warning to human kind: "Do not hunt me any longer." Human violence toward animals puts everyone in peril, animals and humanity alike.
Before Lopez began, he said he wasn't worthy to read "I, Snow Leopard," but he'd try. He said that, as far as he knew, we'd be the very first American audience to hear the poem.
We listened to this exclusive reading in the soaring space that is the chapel in Rochester's Temple B'rith Kodesh. "I, Snow Leopard" is beautiful, haunting, simply expressed and accessible even to listeners not accustomed to hearing poetry.
Photo by Bernard Landgraf. CC BY-SA 3.0
After the reading Lopez answered questions and spoke informally and earnestly. As we listened, the audience seemed to be hanging on his words. Here are some direct quotes I managed to scribble in my notebook:
"Each soul is essential to the warp and weft of the universe."
"I want to see people come alive."
"We know what to do and we have to do it now."
Fixing our world "will take people of great courage. People like you. Because Washington is not doing it."
"We should be holding hands."
"The only thing that really matters is to be in love."
I wrote down the following words, too, but I don't recall if they are from the poem or if they are Barry Lopez's words. I believe they are both:
"There is no other place for any of us to go."
"I, Snow Leopard" is available on Amazon. Barry Lopez told me it is also to be published in a future issue of Orion Magazine.
If you'd like to read Barry Lopez, Arctic Dreams, his nonfiction work about the Far North that won the National Book Award, is a great book to start with. I haven't yet read Of Wolves and Men, but when I saw the mesmerizing cover photo of a wolf on display at the reading, I added it to my to-read list.
Lopez writes fiction, too. I especially liked his subversive collection of short stories, Resistance, which he wrote shortly after 9/11, about surveillance and "parties of interest" to the government.
If you want to know more about the fascinating snow leopard, Peter Matthiessen's memoir, The Snow Leopard, is a great read.
The Secret Life of Walter Mitty, with Ben Stiller and Sean Penn, is one of my favorite movies. Watch it. You might spot a snow leopard.
Great Tide Rising
May 16, 2018 By Valorie Grace Hallinan in Books, Ecology, Libraries, Nature, New York City, Nonfiction Tags: climate change, creativity, extinction, gardens, global warming, Great Tide Rising, habitat destruction, Jefferson Market Library, Kathleen Dean Moore, New York City, New York Public Library, urban gardens	6 Comments
The Oculus, World Trade Center, next to the Freedom Tower. The Oculus structure, said to resemble a bird or a dinosaur, symbolizes rebirth from the ashes. In her book, Kathleen Dean Moore writes that we are shutting down the Cenozoic era. What will arise in its place?
"He was a huge man – I'd guess six-five. Shaved head. Big black overcoat reaching below his knees. Big black dress shoes with rubber soles….
This is my chance, I said to myself, to relate to an oilman in a personal way, and perhaps even learn a little about his heart.
'So,' I said, "Do you have children?'
He knew where I was going with that. He turned to face me straight on. 'Don't you ever,' he said, 'ever. Ever. Ever.' He paused. 'Ever underestimate the power of the fossil fuel industry.'" – Great Tide Rising: Toward Clarity and Moral Courage in a Time of Climate Change, by Kathleen Dean Moore
This is the scary, provocative, grieving, truthful, and energizing book to read if you want to come to grips with climate change and decide what, if anything, you are going to do about it.
Great Tide Rising is not filled with climate science and facts about global warming and how to "solve" it with know-how and technology. In her book, Kathleen Dean Moore, an acclaimed nature essayist, philosopher, and environmental leader, frames climate change and habitat destruction as moral and ethical questions, guiding readers toward possible answers. Two of the gravest moral questions we face are:
Why is it wrong to wreck the world?
What is our obligation to our children, our children's children, and the future?
Moore writes:
"I object…to the language of the sixth extinction and will not use it. The current extinction is something morally different from the first five. For all their horror, for all their calamitous power, the early extinctions were natural Earth processes, what the insurance industry calls 'acts of God,' beyond human control or culpability. This current great wave of dying is the direct result of human decisions, knowing and intentional, or willfully and wantonly reckless. That's a difference of moral significance. It changes a calamity into a cosmic crime, a perversion of human power….To call this just the sixth in a long series of extinction cycles is what philosophers call a 'category mistake'; it's not the same thing. Extinctions one through five call us to awe. Number six calls us to rage – rage against the dying."
For me, Great Tide Rising is a kind of primer, or bible, for our time. A bible in the sense that it contains Moore's eloquent, clarifying language, as well as the wisdom of our greatest environmental prophets, including Aldo Leopold, Edward Abbey, Joanna Macy, and even the poet Mary Oliver.
A bible, too, because it urges us to bear witness to that which must change, and then to act. By "act," Moore does not mean switching to eco-friendly light bulbs; she means for us to seek a larger purpose and vision for our lives in light of the disaster we face. Great Tide Rising is a kind of bible because it can be turned to often for wisdom and guidance as we head into a treacherous future.
"It's a… stunning thing that we face climatic changes that will undermine the lives of our children – and very few people are talking about it….most likely it's a variety of what American intellectual Lewis Mumford called a 'magnificent bribe.' The bargain is that each member of the community may claim every material advantage, every intellectual and emotional stimulus he may desire, in quantities hardly available hitherto even for a restricted minority: food, housing, swift transportation, instantaneous communication, medical care, entertainment, education' – on the condition, I would say, that they never ask where it came from, or at what cost in human suffering, at what cost to the future, or to what long-term effect. That's the deal: If they ask, they have to turn away from their glittering lives."
Great Tide Rising refers not just to sea level rise, but to the growing groundswell of people questioning our way of life and committed to a profound shift in thinking. Joanna Macy calls this The Great Turning. In Macy's words:
"The Great Turning is a name for the essential adventure of our time: the shift from the industrial growth society to a life-sustaining civilization…A revolution is under way because people are realizing that our needs can be met without destroying our world….Future generations, if there is a livable world for them, will look back at the epochal transition we are making to a life-sustaining society. And they may well call this the time of the Great Turning. It is happening now."
Macy, Kathleen Dean Moore, and other environmental leaders do not know if humans and other life forms will survive what is to come, even if we take massive action. The deal is, we are to bear witness and act regardless of the outcome.
For Great Tide Rising, Moore interviewed Mary Evelyn Tucker, a professor at Yale Divinity School and the Yale School of Forestry and Environmental Studies, who spoke of the human instinct to create. Her words compose one of the most beautiful and hopeful passages in the book:
"Humans desire, more than anything else, to be creative, and we desire to participate in the creative processes, in the future and in life – that's what having children is about. But we can be life-generating in a variety of ways – creative, participatory, oriented toward something larger than ourselves….
Our work is to align ourselves with evolutionary processes instead of standing in their way or derailing them. So our human role is to deepen our consciousness in resonance with the fourteen-billion-year creative event in which we find ourselves. Our challenge is to construct livable cities and to cultivate healthy foods in ways congruent with Earth's patterns. We need the variety of ecological understanding so we can align ourselves with the creative forces of the universe.
Something is changing; an era is changing. If we are shutting down the Cenozoic era…the great work is to imagine how the new era can unfold. Our work in the world is not just a stopgap to extinction….We are part of the Great Work, as Thomas Berry would say, of laying the foundation of a new cultural era."
I have only touched on highlights of Great Tide Rising. There is so much more, including a special appeal for grandparents to act on behalf of their grandchildren and future generations.
Times Square and a mantra for our time, maybe one that needs to change. I brought Great Tide Rising on a trip to New York City last week and read it in the evenings. I visited the photography studio where my son works and, walking around Manhattan, I saw many promo posters for The Americans (a favorite series) with photos taken by Pari, my son's employer. This is why I will always love great cities, especially New York, where I once lived: they nurture and embody the human desire to be creative that Mary Evelyn Tucker speaks of in Great Tide Rising.
I found this stunning High Victorian Gothic library in the West Village. Jefferson Market Library, part of the New York Public Library System, was once a women's prison. It is now a quiet, beautiful city space. Perhaps cities will save us. Some environmentalists predict that more people will live in cities, leaving vast tracts of nature to heal and regenerate.
The library is tucked in alongside Jefferson Market Park. I enjoy seeking out small secret gardens in urban places. When Michael Bloomberg was mayor of New York, thousands of acres of parkland were added, nearly 2000 parks were redesigned or upgraded, and a million trees were planted.
A view from the High Line, a repurposed elevated rail line nearly two miles long on the lower West Side. An enchanting garden, especially at dusk, that did not exist when I lived in New York. My son and I walked the High Line, between Tenth and Twelfth avenues, on the way to dinner. Green spaces like this one could be part of the future livable city Mary Evelyn Tucker speaks of in Great Tide Rising.
This post is written in memory of David Buckel, a civil rights lawyer and environmentalist who took his own life in Brooklyn's Prospect Park in April. He self-immolated with fossil fuel to protest its use and left a note: "Most humans on the planet now breathe air made unhealthy by fossil fuels, and many die early deaths as a result — my early death by fossil fuel reflects what we are doing to ourselves. I hope it is an honorable death that might serve others."
The book I still haven't read
March 30, 2018 By Valorie Grace Hallinan in Books, Ecology, Nature, Nonfiction, Sustainable Living, Young Adult Tags: climate change, Elizabeth Kolbert, endangered species, environmental contamination, extinction, MeToo, salmon, sexual harassment, Sherman Alexie, The Absolutely True Diary of a Part-Time Indian, The Sixth Extinction, water, water pollution	9 Comments
Since my last post:
I took The Sixth Extinction: An Unnatural History by Elizabeth Kolbert off my shelf and considered whether I should finally read it. I've avoided doing so, not because I don't have the time, but because I already know the dark ending, implicit in the title.
We learned that a manufacturer's leaky septic tank has been releasing a plume of heavy metals and a cancer-causing chemical, contaminating some of the groundwater and soil in our former upstate New York town. Testing will determine the extent of the contamination. Fortunately, the affected water is not the drinking water. Ironically, my first audio essay on Terrain.org, "Water Bewitched," celebrated our neighborhood's life-giving underground streams and how great it was to raise a family there. I'm not celebrating now.
We are purchasing a few acres of land, and so we plumbed the mysteries of central Oregon irrigation, which is being modernized for less water waste (because mountain snowpack, an important source of water, will decline with climate change) and to restore flow in area waterways. (Strange timing for us, as we mourned the polluted and possibly dangerous groundwater in our former hometown.) Thanks to irrigation upgrades here and other efforts, a local creek no longer dries up every summer and, as of 2016, steelhead trout and chinook salmon seem to be returning. We've had something of a tribute to salmon on this blog of late. For more salmon thoughts, see "The memoir I didn't want to write about" and Turning Homeward.
Indoors, I started lavender, rosemary, chives, kale, and pearl onions from seeds. We reclaimed the raised beds in the backyard of the home we're renting, and so far we've planted carrots, spinach, kale, miner's lettuce, winter lettuce, and maché. Lately, it's been fun to discover flowers blooming in our yard planted by former tenants.
I completed the first half of my Oregon Master Naturalist class. For our final essay, we reflected on whether, to save endangered species, we should "transplant" species back into habitats in officially designated wilderness areas. By law, federal wilderness is typically free of human intervention. In my essay, I wrote that carefully selected species transplants are worth a try. In my heart, though, I believe Naomi Klein, "Only mass social movements can save us now." The question stimulated much discussion and a good share of angst. A classmate doubts moving species around will make a difference, and cited Stephen Hawking: "We must continue to go into space for the future of humanity. I don't think we will survive another 1000 years without escaping beyond our fragile planet." Someone else wrote that, given the sixth extinction, hard choices about which species to save are in order. Triage is required, as in medicine. He went on to say that human efforts will ultimately have no meaning and no importance. Wildlife experts, naturalists, climate scientists, and volunteers are grappling with these issues, while many of our government leaders pretend they don't exist. The cognitive dissonance in our culture is deafening.
The cognitive dissonance in our culture is deafening.
I put The Sixth Extinction back on my shelf for another day. Sometimes, a book of this nature, no matter how critically acclaimed, is just too much information.
After I posted this, someone in my Oregon Master Naturalist class tweeted this must-read article, "A Moon Shot to Protect Earth's Species." If you do not know E. O. Wilson, look him up and try reading one of his books. He's an author to know about. Click on the link here for one of his TED talks.
And this happened in the book world:
So many readers have loved and were inspired by Sherman Alexie's The Absolutely True Diary of a Part-Time Indian, especially young Native Americans and members of other often marginalized groups. (Interestingly, every year this book is on the American Library Association's list of banned and challenged books.) Many of these fans remain blissfully unaware of the scandal that has befallen the author. Those who know about Alexie's recent troubles have been saddened and disillusioned. Books, their heroic characters, and the talented writers who create them can make a huge difference in a young person's life. When these heroes fall, it can be devastating. I was impressed by a recent essay that calls out how we lionize and anoint a single spokesperson for a group, when we'd do better to spotlight a diversity of voices: "Why Sherman Alexie's Sexual Misconduct Seems Like a Betrayal."
The Pacific Northwest Booksellers Association released its new Event Code of Conduct. It is meant for booksellers, librarians, exhibitors, guests, attendees, and volunteers. The new code states, in part:
"Prohibitive behavior includes offensive verbal comments related to gender, gender identity and expression, age, sexual orientation, disability, physical appearance, body size, ethnicity, and religion; deliberate intimidation, stalking, following, sustained disruption of talks or other events; unwelcome photography or recording, physical contact, or sexual attention."
Books, their heroic characters, and the talented writers who create them can make a huge difference in a young person's life. When these heroes fall, it can be devastating.
With climate change, snowpack will decline in central Oregon. A view of two Sisters.
We've been enjoying these for several days.
Barry Lopez brings us I, Snow Leopard
April 15, 2016 By Valorie Grace Hallinan in Books, Ecology, Literature in Translation, Nature, Nonfiction, Poetry Tags: Asian poetry, Barry Lopez, China, Chinese literature, endangered species, extinction, Jidi Majia, poems, snow leopards, wildlife	11 Comments
Male snow leopard


Lighting is one of the primary means of making a place feel safe and inviting and facilitating its use beyond daylight hours. It can be used to elevate and enhance the quality and character of space by providing attractive architectural or artistic design form during the daytime, and a variety of ambiance levels during the night time. This allows the campus to have various types of unique open spaces.
Campus streets and open spaces should be well-lit to create a sense of safety and security, especially in winter, when daylight hours are short.
Lighting design should provide adequate illumination while minimizing light pollution. Dark sky lighting standards should be used to be in keeping with achieving a sustainable design approach.
Energy-efficient lights should be installed throughout the Campus to minimize energy usage.
The lighting design of open spaces should be carefully chosen to complement the use and character of the space and to enhance the unique elements and landscapes within.
Pedestrian scale lighting should be used within the open spaces and streets. Vehicular scaled lighting should be used primarily at street intersections.
The choice and style of light fixtures should contribute to building campus identity and creating a quality environment. The fixtures should complement the architecture and landscape and read as part of an overall package of furnishings for the Campus.
Lighting can be in the form of art, and can be integrated into art forms as well.
The design for the open spaces should include electrical conduits for temporary or decorative lighting installations during festivals and events.
Decorative lighting should not be used on trees. If trees are to be illuminated, lighting should be provided at the ground level or adjacent to the trees in the form of a bollard.


Born out of Bunch, Lunch is a production studio providing bespoke services for design for a diverse range of clients and budgets.
For over a decade we've been building relationships with a vast network of production houses and specialists, working closely alongside them to produce our work.
With a number of commissions for close friends now under our belt, we look to expand our passion for production and help studios realise their own projects.
Our experience as practitioners as well as producers has advanced our expertise in print production and fuelled our curiosity for innovation, quality and detail across the entire creative process.
A production studio providing bespoke services for design.
With over 10 years of experience, Lunch offers a diverse range of print production including stationery, packaging, signage, editorial and collateral print applications.
We love what we do and take great pride in the quality of our services, reliability of our distribution, and are excited to share our production capacity with selective clients.
All of our clients get the individual approach and we treat each project as our own. We have established a large network of specialist production houses, and we can acquire various types of products (merchandising) globally for customisation.
Our design studio Bunch started in London before branching to Zagreb, Croatia. This is now where we do all of our production.
Which print services do you offer?
We offer various print techniques: offset, digital and roto print, screen print, foil print, tampon print, embossing/debossing, thermography, laser engraving and die cutting. Binding options including: perfect binding, swiss binding, pur, stapling and stitching.
We offer 24 hour delivery across EU, and also economy 5 days shipping.
We are experts at encouraging the creative process and offer an array of resources including: paper/cardboard, glass, ceramic, metal, acrylic, foam and plastic. Other materials may be available on request.
We work with major EU paper mills: Arjowiggins, Fedrigoni and GF Smith.
Along with standard print applications we can help with promotional merchandise such as apparel, badges, banners, pencils, pens, mugs, tote bags and many more.
Runs / What is the minimum production order quantity?
There is no minimum production order, we can produce custom and complex single 1-unit applications.
The production work we have done over the years for our design studio Bunch has been featured in a number of design magazines, books and blogs (Design Week, Creative Review, Visuelle, Designboom, The Drum etc).
Everything produced and exported from Croatia is VAT exempt and there are no customs within EU.
Customs may/will apply when importing to non-EU countries.
Get in touch at info@lunchpress.eu and we'll be sure to get back to you within a 24 hour period.
For general enquiries, estimates or to discuss an upcoming project, please drop us a message. We'd love to hear from you.


text:
Toy Bizarre è un videogioco a piattaforme 2D pubblicato nel 1984 per Commodore 64 e nel 1985 per ZX Spectrum dalla Activision. Il codice del gioco originale su Commodore 64 è stato scritto da Mark Turmell, mentre la musica da Russell Lieblich.

Modalità di gioco
In Toy Bizarre il giocatore controlla Merton, il guardiano notturno di una fabbrica di giocattoli, che si trova a fronteggiare la ribellione dei giocattoli, che improvvisamente hanno preso vita. I livelli sono a schermata fissa e composti da piattaforme, tra cui delle coppie di piattaforme a pistone che si sollevano alternativamente saltando sull'altra, e sei valvole. I controlli sono solo correre e saltare, comprese deviazioni al volo durante il salto.

Merton deve scoppiare tutti i palloncini generati dalle valvole toccandoli, prima che scoppino da soli e liberino un nuovo giocattolo. I giocattoli, che normalmente sono letali al contatto, si possono stordire tramite i pistoni, e quindi eliminare andandogli addosso. L'unico giocattolo che non è possibile sconfiggere in questo modo è la bambola Hilda, di cui ci si può liberare soltanto temporaneamente utilizzando i pistoni che la fanno schizzare via. Merton può anche chiudere buona parte delle valvole, ma Hilda le riapre toccandole.

Ogni volta che un livello viene completamente ripulito da ogni giocattolo e dal numero di palloncini richiesto, il giocatore passa a un livello successivo, leggermente più difficile, che deve essere sempre risolto entro un tempo limite. Esistono anche livelli speciali senza palloncini, dove lo scopo è chiudere tutte le valvole insieme mentre Hilda le riapre.

Bibliografia

Collegamenti esterni

redpajama_set_name: RedPajamaWikipedia


text:
rmdir lib /s /q
.\src\util\buildScripts\build.bat --profile app.profile.js

redpajama_set_name: RedPajamaGithub


Rocket Language incorporates great listening, speaking, and writing practice. Each lesson covers prior lessons so you're always practicing what you've learned earlier. Rocket Language is well worth the investment of time and money!


Posted on December 29, 2013, in Blogging, Business, facebook, Pinterest, Social Media Marketing, twitter, YouTube and tagged Advertising, blog marketing, Blogging, brand, Branding, Business, business practices, customer service, email marketing, facebook, How to Marketing, linkedin, measuring social media, networking, pinterest, pull marketing, push marketing, roi, social marketing, social media, social space, twitter, Viral Marketing, web marketing. Bookmark the permalink.	Leave a comment.


(Chicago) February 7, 2019 – Among the top two percent of North American staffing agencies, Medix, a national organization specialized in workforce solutions and recruiting skilled personnel for clients in the Scientific, Healthcare and Information Technology industries, has been recognized as one of ClearlyRated's Best of Staffing® Client and Talent Awards winners for providing excellent service to clients and placed talent.
Presented in partnership with CareerBuilder, ClearlyRated's Best of Staffing® winners have proven to be industry leaders in service quality based entirely on ratings by their clients and the candidates they've helped find jobs. On average, clients of winning agencies are 2.2 times more likely to be completely satisfied, and candidates who have been placed by winning agencies are 1.7 times more likely to be completely satisfied with the services provided compared to those working with non-winning agencies.
For more information about Medix on ClearlyRated's 2019 Best of Staffing® Client and Talent awards, visit BestofStaffing.com.
Medix provides workforce solutions to clients and creates opportunity for talent representing a variety of industries through our Healthcare, Scientific and Information Technology divisions. Medix has been featured as well as one of Staffing Industry Analysts' "Largest Staffing Firms in the United States," as well one of the "Fastest Growing Staffing Firm in the United States." Medix has also been ranked as one of the Best & Brightest Places to Work in the Nation for two years and in ClearlyRated's 2019 "Best of Staffing" Talent and Client awards for providing excellent service, further earning our reputation as an industry leader. For more information, call (866) 44-MEDIX or visit www.medixteam.com.
This entry was posted in Medix Newsroom and tagged awards, Best of Staffing, ClearlyRated, excellent service, Job search, Job Seekers, service, Staffing, workforce solutions. Bookmark the permalink.


text: Q: Use sudo with an EACCESS error when installing firebase? I tried to install npm install -g firebase-tools and I got an "EACCES: Permission denied" error. I have been reading up on a solution and most people say just to write "sudo" in front of the command but I was told said that sudo was bad practice. What is the best solution here?


text:
Q: NT_STATUS_ACCESS_DENIED listing \* - Samba Server I'm trying to setup a CentOS 7 samba server but I just can't make some permissions work.
All my files and directories are allowed only to their respective owners, e.g:
drwxrwx---.  5 root setcob        4.0K Feb 12  2016 setcob
drwxrwx---+  7 root setorpessoal  4.0K Oct 25 19:30 setorpessoal

But when I connect via smbclient, I can't ls inside setorpessoal.
smb.conf:
[global]
        workgroup = workgroup
        netbios name = sambaserver
        netbios aliases = sambaserver
        server string = sambaserver
        map to guest = Bad User
        passdb backend = smbpasswd
        log level = 4
        log file = /var/log/samba/%U.log
        max log size = 1000
        max xmit = 65535
        deadtime = 15
        socket options = TCP_NODELAY IPTOS_LOWDELAY
        os level = 100
        preferred master = Yes
        domain master = Yes
        dns proxy = No
        wins support = Yes
        full_audit:prefix = %u|%i|%S
        recycle:keeptree = yes
        recycle:versions = yes
        recycle:repository = /mnt/samba/lixeira
        recycle:exclude = *.tmp, *.log, *.obj, ~*.*, *.bak, *.iso
        recycle:exclude_dir = tmp, cache
        invalid users = root
        admin users = user1, user2, user3
        write list = user1, user2, user3
        veto files = /~*/
        hide files = /~*/
        vfs objects = recycle

[setorpessoal]
        comment = Setor Pessoal
        path = /mnt/samba/setorpessoal
        valid users = @setorpessoal, setorpessoal, user1, user2, user3
        read only = No
        force create mode = 0777
        force directory mode = 0777
        write cache size = 384000
        veto files = /*.mp3/*.wav/*.tif/*.pif/
        recycle:keeptree = yes
        recycle:versions = yes
        recycle:repository = lixeira
        recycle:exclude = *.tmp, *.log, *.obj, ~*.*, *.bak, *.iso
        recycle:exclude_dir = tmp

Log error:
[2018/10/26 17:41:52.458256,  3] ../source3/smbd/service.c:120(set_current_service)
  chdir (/mnt/samba_novo/samba/setorpessoal) failed, reason: Permission denied
[2018/10/26 17:41:52.458296,  3] ../source3/smbd/smb2_server.c:3120(smbd_smb2_request_error_ex)
  smbd_smb2_request_error_ex: smbd_smb2_request_error_ex: idx[1] status[NT_STATUS_ACCESS_DENIED] || at ../source3/smbd/smb2_server.c:2472

I'm using CentOS 7 with Samba 4.7.1.

A: Okay, I found the problem: I didn't set my new permissions to its root directory.
All the folders were OK, but /mnt and /mnt/samba belonged to root. I've set to 777.
BTW, I also disabled SElinux.


text:
import { AddObjectCommand } from './AddObjectCommand.js'
import { AddScriptCommand } from './AddScriptCommand.js'
import { MoveObjectCommand } from './MoveObjectCommand.js'
import { MultiCmdsCommand } from './MultiCmdsCommand.js'
import { RemoveObjectCommand } from './RemoveObjectCommand.js'
import { RemoveScriptCommand } from './RemoveScriptCommand.js'
import { SetColorCommand } from './SetColorCommand.js'
import { SetGeometryCommand } from './SetGeometryCommand.js'
import { SetGeometryValueCommand } from './SetGeometryValueCommand.js'
import { SetMaterialColorCommand } from './SetMaterialColorCommand.js'
import { SetMaterialCommand } from './SetMaterialCommand.js'
import { SetMaterialMapCommand } from './SetMaterialMapCommand.js'
import { SetMaterialValueCommand } from './SetMaterialValueCommand.js'
import { SetPositionCommand } from './SetPositionCommand.js'
import { SetRotationCommand } from './SetRotationCommand.js'
import { SetScaleCommand } from './SetScaleCommand.js'
import { SetSceneCommand } from './SetSceneCommand.js'
import { SetScriptValueCommand } from './SetScriptValueCommand.js'
import { SetUuidCommand } from './SetUuidCommand.js'
import { SetValueCommand } from './SetValueCommand.js'

export {
	AddObjectCommand,
	AddScriptCommand,
	MoveObjectCommand,
	MultiCmdsCommand,
	RemoveObjectCommand,
	RemoveScriptCommand,
	SetColorCommand,
	SetGeometryCommand,
	SetGeometryValueCommand,
	SetMaterialColorCommand,
	SetMaterialCommand,
	SetMaterialMapCommand,
	SetMaterialValueCommand,
	SetPositionCommand,
	SetRotationCommand,
	SetScaleCommand,
	SetSceneCommand,
	SetScriptValueCommand,
	SetUuidCommand,
	SetValueCommand
}


text:
Q: Merge two file line by line using awk I have got two files named file1.txt and file2.txt.
file1.txt :
Tom
Harry
Martin
job
Kevin

file2.txt :
Samson
Edward
Thomas
Wilco

Mergefiles.txt:
Tom
Harry
Martin
job
Kevin
Samson
Edward
Thomas
Wilco

I am using "cat" to merge these files but would like to know if this a good approach or can be done using awk command. pLease help.
cat file1.txt file2.txt > mergefiles.txt

A: cat was created specifically for this purpose. It means to "concatenate" files and that appears to be the operation here, so that is a good approach.

You could get the same behavior with awk :
awk 1 file1.txt file2.txt > concatenatedfiles.txt

But there really is no point in doing that if cat can do the same thing...


text:
Die Goyder Lagoon  ist ein großes, nicht ganzjährig mit Wasser gefülltes Sumpfgebiet im Nordosten des australischen Bundesstaates South Australia.

Sie liegt nordöstlich des Birdsville Track nahe der Grenze zu Queensland und gehört zur Flussaue des Diamantina River. Besonders hohe Wasserstände im Georgina River und im Mulligan River können dafür sorgen, dass dem Sumpf an seiner Nordwestseite über den Eyre Creek Wasser zugeführt wird. Der Wasserabfluss erfolgt über den Warburton River. Der größte Teil des Sumpfes besteht aus seichten, verflochtenen, kleinen Kanälen. Das Gebiet gehört zur Rinderstation Clifton Hills Station auf Kronland.

Im Mittel betragen die jährlichen Regenfälle 100–150 mm und die Sommerhöchsttemperaturen 36–39 °C.

Das Sumpfgebiet wurde nach dem Geodäten und Entdecker George Goyder benannt.

Vögel
Ein Gebiet von 2.684 km² unter Einbeziehung der Goyder Lagoon wurde von BirdLife International zur Important Bird Area (IBA) erklärt, hauptsächlich weil sich dort bei Flut viele Wasservögel niederlassen. 2002 wurden bei einer Zählung aus der Luft insgesamt 170.000 Stück geschätzt. Die größten Ansammlungen von Wasservögeln finden sich im Südteil des Sumpfes, darunter verschiedene Arten von Kormoranen, Enten, Reihern und Ibissen. In der IBA finden sich über 1 % des Weltbestandes an Affenenten (Stictonetta naevosa), Lachseeschwalben (Gelochelidon nilotica) und brütenden Königslöfflern (Platalea regia). Eine kleine Population des Safrantrugschmätzers (Yellow Chat, Ephthianura crocea) aus der Familie der Honigfresser findet sich im Koonchera Waterhole. Andere Vogelarten, für die der Sumpf einen wichtigen Lebensraum bietet, sind der Schwarzachselaar (Letter-winged Kite, Elanus scriptus), der Gürtelregenpfeifer (Charadrius australis), die Australischen Sänger Brauengrasschlüpfer (Amytornis barbatus) und Eyregrasschlüpfer (Amytornis goyderi), Honigfresser wie der Trauerhonigfresser (Sugomel nigrum syn. Certhionyx niger), der Elsterhonigfresser (Certhionyx variegatus) und Wüsten-Trugschmätzer (Gibberbird, Ashbyia lovensis), der Banded Whiteface (Aphelocephala nigricincta, Familie Südseegrasmücken), der Buschflöter (Chirruping Wedgebill, Psophodes cristatus) und der Zimtflöter (Cinnamon Quail-Trush, Cinclosoma cinnamomeum).

Einzelnachweise

MGoyder Lagoon
Gewässer in South Australia
Sumpfgebiet
Important Bird Area in Australien
Schutzgebiet (Umwelt- und Naturschutz) in Australien


text:
Q: How to set wifi ssid specific static ip address in netplan I am running ubuntu server in my machine, and using netplan for connecting with wifi.
There are two wifis configured in netplan, one as primary, second as backup

I have requirement to keep ip address stable for primary wifi, but to keep dynamic for secondary wifi. If I set static IP address, it applies for all wifis.
I already looked at all the example presented at official site : https://netplan.io/examples/
and also gone through their official documentation : https://netplan.io/reference
Checked many stackoverflow answers and askubuntu answers, but still not able to find how to do that.
How to set static IP address for one wifi network but keep other wifi connections default setting?


text:
The Changing Strand
By Arthur Woodgate
It was astonishing that anyone should suggest that gas was not made in Rye, but only stored. IT gave me the thought, however, that the strand in Rye had changed during the 20th Century and was worth recording.
I have seen it go from sailing ships to motor bikes and petrol and diesel powered yachts.
I suppose, the first change of the first change was the introduction of the iron hauls of the steam trawlers Kent Colebrooke and Alfred Colebrooke and the third one Margaret Colebrooke which was blown up during the first World War. They used to birth by St Margarets Terrace.
There was an enclosed coal store close by, Now gone to allow for road alterations, the old road used to twist around the stand, inland of the Warehouses and mills. The present road between quay and the warehouses was just a rough piece of ground with footpath running by the coal store, so Capt.> Page, one time skipper of a steam trawler, could no longer retail coal from there. Mr Colebrooke was a famous strand personalities, at the start of the century and by 1913 was the Mayor of Rye, as well as his shipping activity he established a mineral water factory the when it all came about he was at the height of his prime in no time at all in some of his property on the strand. He used the type of bottle that was sealed with a marble, and he had moulded into the glass a picture of one of his fishing fleet, RX1 Goldie.
When the steam trawlers were getting into the new (20th) Century of 1900 my recollection of the river was the decaying carcass of the fishing smack "Pert" RX181 which had been its glory, together with some 50 other smacks over the 19th and 20th Century change.
She laid on her side on the West bank at the gas works end, we youngsters used to play in and around her until a Mr. Firrell broke her up for firewood. So there we had next to her the Marine Engineer workshop of Mr. Alf Gall, giving us the 100 years of ship propulsion through wind, steam and internal combustion.
With the steam trawlers at their moorings and several sea going barges, unloading cargos of around 200 tons each, of basic slag, cement, timber etc. and above all coal it was a busy strip of water. On one occasion a load of bricks were brought in from Belgium, and dumped on the Quay side. The then borough Surveyor. Mr. A J Cornner condemned them from being used on any Rye property. He was right, of course, because they remained there and became a lump of pink dust. Most products were wheeled across planks and into the warehouses. Coal was unloaded in the same way for retail use, onto both the west and east banks, but most was wheeled into the Gas Works. Gang planks were not used only to bridge across the water, but were also placed on the road to make it easier for the men to push five Cwt of coal in wheelbarrows into the gas works coal store. The traffic just had to slow down and jump the planks, but there wasn't very much motor traffic then. Very hard work, but before 1928 the Kettle of Fish big window was a solid wall with a plinth about a foot up from the pavement. Men would squat on the plinth hoping for an unloading job. Those who were engaged on timber boats; to my mind had the hardest jobs of all the work undertaken by the old Ryers along the banks of the Tillingham, between the Brede sluice and the Tillingham sluice. They had to wear very thick shoulder pads and the two long lengths of wood would whip up and down as they tried to keep in step as they crossed a jumping gang plank on their way to dump their load on a stack on the deals. Isn't it a pity that the names of The Deals and Havelock Villas were not included in the new buildings on The Deals, but modern developments are interested in only one thing "Money".
Back to the Gas works I have documentary evidence that the Rye Gas and Coke Company was there in 1892 (no north sea gas then) and I have pictures showing the retort buildings, what is more, I know the stokers in the 1920s. Very friendly men, some of whose names I remember well. Arthur Devonshire, Ernie Jago, and Alf Case not only made the gas they were responsible for pulling on the street lights. At the times of year, when lighting up time came when schools were turning out for the day, we Mermaid Street Boys who lived in the Strand area, would race down Mermaid Street, across Kitty Corner, on to the Wharf, along in front of the deals and Havelock villas and into the stokers cabin. The first boy there would be given the hooked stick and allowed to go round town and pull on the lights. It was inevitable, that in the scramble that some of us should fall over and this seemed to amuse Mr. Devonshire. When he saw blood running down our knees and he would wave a piece of rag as we went by. At other times we would play our way home, along the Strand with out nipcap balls or what ever else we had to hand. One afternoon Geof Gladwish and I were kicking a ball around when a sudden crash told us our ball had broken a window. Our two fathers got together and decided that the five shillings would be paid for by our one penny a week given us for pocket money, so we had no sweets for thirty weeks.
During and just after the first World War, when coal gas was being used to drive motor vehicles there was a tap on top of the gas works wall (about where the brick boat is now). The East Kent Road car company was just getting under way and their buses used to come and fill their big gas balloons on their roofs. If we lads hung about the drivers would give us a ride to their garage by the foundry. David Paine (letter in Rye Observer 07/05/04) was lucky to earn pocket money for picking out coke from the slag from the retorts. My Victorian minded father used to take sixpence and a big sack into the gas office and I had to go from school and put as much coke in the sack as I could and father would pick it up on his way home from work. No extra pocket money. In 1928 The gas Monopoly was threatened, as in moved the giant cable drums of the Electricity Company, many of which were temporary stored on the strand, an army of men pulled cables through replace pipes. The gas company realising they now had serious competition had a hole cut in their road side wall to put in a shop front, to show off their latest gas appliances. At 15 years of age, I spent many days helping punch through that brick wall with 2.5 Ib club hammer and chisel and I can still feel the pain in my shoulders and arms when I think about it now.
From Rye's Own August 2004
Posted on 1st August 2004 15th January 2017 Author Jim HollandsCategories Local interest, MarineTags Alfred Colebrooke, Arthur Woodgate, Brede, Havelock Villas, Kent Colebrooke, Margaret Colebrooke, Marine Engineer, Mr. A J Cornner, Mr. Alf Gall, Mr. Firrell, RX1 Goldie, St Margarets Terrace, Tillingham, World War
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