text:
Title: Ring of Gyges
Subject: Platonism, Gyges of Lydia, Power ring, Philosopher king, Platonic epistemology
Collection: Concepts in Ethics, Greek Mythology, Individual Items of Jewellery, Invisibility in Fiction, Magic Objects, Mythological Objects, Platonism, Rings
The Ring of Gyges is a mythical magical artifact mentioned by the philosopher Plato in Book 2 of his Republic (2.359a–2.360d).[1] It granted its owner the power to become invisible at will. Through the story of the ring, Republic considers whether an intelligent person would be moral if he did not have to fear being caught and punished for doing injustices.
The legends 1
The role of the legend in Republic 2
Gyges of Lydia was a historical king, the founder of the Mermnad dynasty of Lydian kings. Various ancient works—the most well-known being The Histories of Herodotus[2]—gave different accounts of the circumstances of his rise to power.[3] All, however, agree in asserting that he was originally a subordinate of King Candaules of Lydia, that he killed Candaules and seized the throne, and that he had either seduced Candaules's Queen before killing him, married her afterwards, or both.
In Glaucon's recounting of the myth (which is clearly not based on historical fact), an unnamed ancestor of Gyges[4] was a shepherd in the service of the ruler of Lydia. After an earthquake, a cave was revealed in a mountainside where he was feeding his flock. Entering the cave, he discovered that it was in fact a tomb with a bronze horse containing a corpse, larger than that of a man, who wore a golden ring, which he pocketed. He discovered that the ring gave him the power to become invisible by adjusting it. He then arranged to be chosen as one of the messengers who reported to the king as to the status of the flocks. Arriving at the palace, he used his new power of invisibility to seduce the queen, and with her help he murdered the king, and became king of Lydia himself.
The role of the legend in Republic
In Republic, the tale of the ring of Gyges is described by the character of Glaucon who is the brother of Plato. Glaucon asks whether any man can be so virtuous that he could resist the temptation of being able to perform any act without being known or discovered. Glaucon suggests that morality is only a social construction, the source of which is the desire to maintain one's reputation for virtue and justice. Hence, if that sanction were removed, one's moral character would evaporate.
Glaucon posits:
Suppose now that there were two such magic rings, and the just put on one of them and the unjust the other; no man can be imagined to be of such an iron nature that he would stand fast in justice. No man would keep his hands off what was not his own when he could safely take what he liked out of the market, or go into houses and lie with any one at his pleasure, or kill or release from prison whom he would, and in all respects be like a god among men.
Then the actions of the just would be as the actions of the unjust; they would both come at last to the same point. And this we may truly affirm to be a great proof that a man is just, not willingly or because he thinks that justice is any good to him individually, but of necessity, for wherever any one thinks that he can safely be unjust, there he is unjust.
For all men believe in their hearts that injustice is far more profitable to the individual than justice, and he who argues as I have been supposing, will say that they are right. If you could imagine any one obtaining this power of becoming invisible, and never doing any wrong or touching what was another's, he would be thought by the lookers-on to be a most wretched idiot, although they would praise him to one another's faces, and keep up appearances with one another from a fear that they too might suffer injustice.
— Plato's Republic, 360b–d (Jowett trans.)
Though his answer to Glaucon's challenge is delayed, Socrates ultimately argues that justice does not derive from this social construct: the man who abused the power of the Ring of Gyges has in fact enslaved himself to his appetites, while the man who chose not to use it remains rationally in control of himself and is therefore happy. (Republic 10:612b)
H. G. Wells' The Invisible Man has as its basis a retelling of the tale of the Ring of Gyges.[5]
One story arc in the comic book series The Spectre features a giant Ring of Gyges.[6]
Alberich's Ring in the Richard Wagner's opera Der Ring des Nibelungen (The Ring of the Nibelung)
Gyges's Ring appears in the fantasy novel "Zelda Pryce: The Razor's Edge" (2013) by Joseph Robert Lewis as a physical device with the "arcane" ability to make its wearer invisible.
The One Ring from J. R. R. Tolkien's The Hobbit and The Lord of the Rings grants invisibility to its wearer but corrupts its owner, and both were found in a cave. Although there is speculation[7] that Tolkien was influenced by Plato's story, a search on "Gyges" and "Plato" in his letters and biography provides no evidence for this. Unlike Plato's ring, Tolkien's exerts an active malevolent force that necessarily destroys the morality of the wearer.[8]
In his poem "Like a Sentence" John Ashbery wrote, "And it was said of Gyges that his ring / attracted those who saw him not," implying that death (the poem's overall subject) draws even those who ignore it.
Cicero retells the story of Gyges in De Officiis to illustrate his thesis that a wise or good individual bases decisions on a fear of moral degradation as opposed to punishment or negative consequences. Cicero follows with a discussion of the role of thought experiments in philosophy. The hypothetical situation in question is complete immunity from punishment of the kind afforded to Gyges by his ring.[9]
Robertson Davies' novel Fifth Business discusses the story of the Ring of Gyges.
Online disinhibition effect
^ Herodotus 1.7–13
^ 359d: "τῷ [Γύγου] τοῦ Λυδοῦ προγόνῳ". In Republic, Book 10 (612b), Socrates refers to the ring as "the ring of Gyges" (τὸν Γύγου δακτύλιον ). For this reason, the story is simply called "The Ring of Gyges".
^ Gardner Fox (w), Murphy Anderson (a). "The Ghost of Ace Chance!" Showcase 64 (Sept.–Oct. 1966), DC Comics
^ Tolkien, The Lord of the Ring, Book I, Chapter 2, "The Shadow of the Past".
^ De Officiis 3.38–39
Glaukon's Challenge Glaukon's speech from book 2, translated by Cathal Woods (2010).
RepublicPlato, Book 2, translated by Benjamin Jowett (1892).
The Ring of Gyges Analysis by Bernard Suzanne (1996).
Mythological objects
Concepts in ethics
Magic objects
Invisibility in fiction
Individual items of jewellery
Turkey, Phrygia, Herodotus, Lycia, Caria
Mircea Eliade, Greek mythology, Hindu mythology, Joseph Campbell, Narrative
Institute of Electrical and Electronics Engineers, Data warehouse, Genomes OnLine Database, Global-scale Observations of the Limb and Disk, GOLD (parser)
Logic, Epistemology, Ethics, Metaphysics, Aesthetics
Neoplatonism, Christianity, Plato, Philosophy, Socrates
Gyges of Lydia
Lydia, Bible, Plato, Egypt, Socrates
Power ring (DC Comics), Middle-earth, Der Ring des Nibelungen, Ecclesiastical ring, Green Lantern Corps
Philosopher king
Plato, Philosophy, Raphael, Platonism, Neoplatonism


text:
Q: How to add captcha in product review form in magento2? I am trying to add Captcha inside product review form. For that i add
<referenceContainer name="form.additional.info">
            <block class="Magento\Captcha\Block\Captcha" name="captcha" after="-" cacheable="false">
                <action method="setFormId">
                    <argument name="formId" xsi:type="string">user_login</argument>
                </action>
                <action method="setImgWidth">
                    <argument name="width" xsi:type="string">230</argument>
                </action>
                <action method="setImgHeight">
                    <argument name="width" xsi:type="string">50</argument>
                </action>
            </block>
        </referenceContainer>
        <referenceBlock name="head.components">
            <block class="Magento\Framework\View\Element\Js\Components" name="captcha_page_head_components" template="Magento_Captcha::js/components.phtml"/>
        </referenceBlock>

in theme/Magento_Review/layout/catalog_product_view.xml file. and after that i am calling it in /theme/Magento_review/template/form.phtml file like
<?php echo $block->getLayout()->getBlock('form.additional.info')->toHtml(); ?> But after that no captcha is showing in the review form. Please help me to do it. Thanks

A: To use google reCaptch :
Go to Admin -> Store -> Configuration -> Security Tab -> Google reCaptcha -> Frontend -> Enabled = Yes
Use in Review = select Yes
Add getChildHtml('form.additional.info') ?> in your theme's Magento_Review /templates/form.phtml file.

A: To add google reCaptcha in the product review form please check the following steps:

*

*Step 1: Go to Admin > Stores > Settings > Configuration > Security Tab > Google reCaptcha Storefront

*Step 2: Fill out the section of reCAPTCHA type(s) as per your requirement, you can check about this in detail from https://docs.magento.com/user-guide/stores/security-google-recaptcha.html

*Step 3: From Storefront section, uncheck the Use system value checkbox for Enable for Product Review location field and set it to the reCAPTCHA type that you have configured in the last step.

*Step 4: After Completion, Save Config and Check.

*Magento 2 have added 'recaptcha' block in 'product.review.form.fields.before' container of product review form's block and it's called from \vendor\magento\module-review\view\frontend\templates\form.phtml file as 'getChildHtml('form_fields_before') ?>'

redpajama_set_name: RedPajamaStackExchange


Description: Church Rock Senior Ctr is a business categorized under senior citizens service, which is part of the larger category individual & family social services. Church Rock Senior Ctr is located at the address PO Box 549 in Church Rock, New Mexico 87311-0549. You can contact by phone (505)488-6558.


text:
Commonwealth Bank passes on 40 basis points
Commonwealth Bank (CBA) has cut its standard variable home loan rate by 40 basis points to 7.01%.
The decision came two days after the Reserve Bank of Australia (RBA) announced a surprise 50 basis point cut to the cash rate.
The banking giant said the rate cut would take effect on May 11.
"In making this decision, the group has continued to balance the interests of its 1.8 million home loan borrowers with those of its 11 million depositors, and those of its shareholders, who include 800,000 Australians who own its shares directly, and millions more Australians who own shares through pension funds," the bank said.
CBA's other lending rates and deposit account rates were under review, according to a spokesman.
NAB cut its variable home loan rates by 0.32%, also less than the RBA's 50 basis point cut on Tuesday.
Westpac is keeping tight-lipped on any interest rate cuts as it announced a drop in net profit.

redpajama_set_name: RedPajamaCommonCrawl


This is a 1 year old demo pair of Rega RX-3 speakers. In excellent condition except for one small flaw/chip on the bottom right side of one speaker - see pics). They have very low hours and come factory box, manual, and warranty. Retail new these are $1,995/pair, this demo pair is yours for $1,150 plus shipping. The RX3 is a small speaker that works great in smaller to mid size rooms. It fairly efficient too and a easy 6 ohm load - works great with tube and solid sate gear.
"The Rega RX-THREE loudspeaker system delivers balance, detail and dynamics thanks to a unique handmade set of three Rega designed drivers and crossover. The newly developed DX-125 bass mid-range driver (using a doped paper cone) is at the heart of the RX range and combines perfectly with the Rega ZRR high frequency and RR125.8 bass unit. These custom units are mounted in a newly designed cabinet enclosure constructed from 18mm MDF and covered in a choice of three, beautiful, real wood veneers. The RX-THREE will integrate perfectly into any home and deliver exceptional performance and musicality with a smooth and accurate bass response."
Signature Sound is a small Hi-End HiFi shop located near Syracuse New York. We have been in business since 1990. Feel free to check out our website www.sigsound.com or call us at 315-622-4137 with any questions. We accept all major credit cards and PayPal. A note to my fellow New Yorkers.... New York state residents (i.e sales billed/shipped to a New York State address) will be charged applicable local New York state sales tax on the total sale amount.
Signature Sound is a authorized dealer for: Audience Cables, Atma-Sphere, Clearaudio, Cardas Cables, Benz Micro Cartridges, Fried Audio Speakers, DH Labs, Dynavector, EAR USA, Grado Labs, JPS Labs, Joule-Electra, iFi Audio, Merlin Music Systems, Musical Surroundings NOVA phono preamps, Power Modules (Belles), Rega Research, Rogue Audio (NEW!), Running Springs Audio, Spendor Audio, Sonos, and Wavelength Audio.
Follow us on Facebook to see our latest news, info, and sales/demo/used items for sale!


text:
Welcome to www.heavyliftpfi.com. This site uses cookies. Read our policy.
Heavy Lift Awards 2020
Heavy haulage and trailers
Under the jib
Jacks, skates and rollers
2020 digital editions
Airfreight Solution of the Year
Environment Award
Forwarder Network of the Year
Overland Transport Provider of the Year
Port/Terminal Operator of the Year
Project Logistics Provider of the Year
Safety Award
Shipping Line of the Year
Training Award
FROM THE MAGAZINE: Power to revive the global economy?
FROM THE MAGAZINE: Awakening to a future of online upskilling
FROM THE MAGAZINE: Tidal power awaits commercial surge
December 2020 digital edition
October/November 2020 digital edition
Readers Vote Awards: winners revealed!
HLPFI launches Readers' Vote Awards
Logitrans 2011 exhibition exceeds expectations in Istanbul
By HeavyLiftPFI2011-12-21T00:00:00+00:00
December 21 - The fifth transport logistics exhibition, Logitrans held this month in Istanbul, has exceeded the expectations of its organisers, with more than 12,000 visitors, which represented an increase of 37 percent over 2010.
"This good result clearly demonstrates the importance of Turkey for the international shipping industry and logistics. Its function as a bridge to Asia is also very important for the European market, as confirmed by the increase experienced by the volume of visitors and exhibitors, especially from Germany and Italy, "said Gerhard Gerritzen, a member of the board of Messe Munich, co-ordinator of the event.
The percentage of international visitors was 21 percent of the total. The number of participating countries increased from 13 to 23 and Italy, Germany, Latvia, Czech Republic and Austria bought clusters of their logistics services under the umbrella of their national pavilions. According to the regional director for Istanbul the Turkish Ministry of Transport,Hamza Demirdelen, transport and logistics is gaining a "position each increasingly strategic "in Turkey. "Every step taken to improve the logistics sector also helps to position our country as a 'hub' for international trade logistics," he said. The next edition of Transport Logistics Exhibition Logitrans will take place from 15 to 17 November 2012 in Istanbul .
Oliver Ward, who attended on behalf of Heavy Lift & Project Forwarding International Magazine said "unsurprisingly there were many companies on display deeply involved in the management of industrial projects. Not only is Turkey still investing in important energy and infrastructure projects itself, but its position as a gateway to the Black Sea, Caspian Sea, Central Asia and the northern Middle East means that many Turkish companies can play an important role in facilitating the smooth and safe delivery of valuable, time sensitive, oversized cargoes to some of the most challenging and remote destinations on earth. Their ability to perform these extraordinary movements was on display for all to see."
HLPFI is producing an analysis of the Turkish market in its Jan/Feb edition. If you wish to advertise your services to our influential readership please contact Oliver at oliver@heavyliftpfi.com
Al Faris opens in Iraq
Al Faris has started operations in Iraq with a fleet of heavy lifting and heavy haulage equipment.
UHL Faith delivered
United Heavy Lift (UHL) has taken delivery of the first in a series of eight F900 Eco-Lifters.
Albany welcomes wind tower manufacturing development
The port of Albany in New York, USA, has been selected for the development of an offshore wind tower manufacturing site.
Expansion under way at Omega Morgan
USA-based Omega Morgan has taken full control of its joint venture with Sarens – Omega Morgan Sarens.
Casper Shipping acquires HC Shipping
UK-based port agency, logistics and marine services group Casper Shipping will acquire HC Shipping & Chartering.
Logistec continues its expansion
Canada-based Logistec Stevedoring has acquired Castaloop and its subsidiaries.
Follow Heavy Lift & Project Forwarding International on social media
© 2020 Heavy Lift & Project Forwarding International
HLPFI is a division of DVV Media International Limited


The Powerpoint presentations are used for public speeches. It occurs so often that you may think that you should start using something else to make your performance look great. Most of the people think that they can really prepare a presentation within a few minutes and it will look great. These people are wrong. If you spend a little time on the preparation, your listeners will become angry with you. Because they have spent money and time on you and what you give them back is a boring set of tables and texts.
Many office workers use presentations for all kinds of reports and meetings with their clients. And usually, they have to do this so often that they don't have time for normal preparation. Can it be the reason for not using this kind of visualization? No. There's a way out. Start using Power Point templates to save time. You can use one template for one type of speech.
How to find out you don't use the presentation properly? It's easy. Look into the eyes of the people. Are they looking at you? Are they staring at their gadgets screens? What do you see in their eyes? If you can't do this because you're busy with the speech, your presentation will fail. You should always be in touch with the visitors. So the only reason not to use PowerPoint is your personal desire and nothing more.
Indicate the key idea of the speech. It means you don't have to write a huge text on the screen and show it to people. It means you show only a few words that describe the whole speech. You can use any kind of visuals here, but you should make it easy to understand.
Show the plan of your performance. You can make an ordinary list with items or make it look more fun and interesting. You can add more colors, shapes, but do not overdo this.
Show connections, reasons, and conclusions. Just imagine the teacher explaining what a triangle is without any visuals. It will be a nonsense.
Evoke feelings and emotions. If your presentation cannot evoke anything, you fail. You should use this powerful tool not for manipulation, but for making people trust you and believe in your words.
If you want to make your public speech look and sound great, you should use PowerPoint presentations. You will need to spend enough time on preparing it, testing on different listeners and find the right templates to save your time and money.


Like city for which it is named, the Roma collection balances classic style and design with a penchant for fun and excitement. This line of Luigi Bormioli Roma stemware and barware is perfectly suited for dignified gatherings or the liveliest of toasts. The Luigi Bormioli Roma Glasses are made of SPARKX ultra clear and durable glass.


text:
ABIL-Immigration-Updates
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UNITED KINGDOM: Changes to the Life in the UK Test
from ABIL Global Immigration Update
On January 28, 2013, an updated Life in the UK Test handbook was published for all applicants wishing to settle in the UK or apply to be naturalized as a British citizen. The updated handbook will be applicable to the new Life in the UK test, which will be introduced on March 25, 2013.
Those who have already taken the existing test but have yet to submit their indefinite leave to remain or naturalization applications do not need to take the new test, even if they will not be submitting their applications until after March 25.
Those who intend to take the Life in the UK test after March 25 should review this latest handbook because the new test will include questions on all sections of the new handbook and not just a few selected chapters, as is the case now. There is also a greater focus on British culture and history in the new test. Full details of where to purchase the handbook and how to take the test can be found on the UKBA WEBSITE.
BELGIUM: Renewed Focus on Compliance Issues
There is a renewed focus on compliance issues.
There has been an increasing focus on compliance issues in Belgium, such as in the field of cross-border employment. For example, the Belgian government has begun an initiative against fraud and abuse regarding social security in the context of international mobility.
European regulations have set rules to determine what legislation applies in a particular situation. For example, an employee who is posted by his German employer to Belgium will, under certain conditions, remain subject to German social security; he will receive an "A-1" document from the German social security authorities as proof.
At present, as confirmed by European case law, European Union Member States' courts must accept an A-1 document, even if it is subject to discussion. Only the Member State that has issued the document can withdraw it. For instance, if there were discussion about the real nature of the posting of the German employee to Belgium, a Belgian court must still accept the German A-1 document as long as it has not been withdrawn.
A new rule effective January 10, 2013, entitles Belgian courts to set aside the European coordination rules in the event of "abuse," which is defined as the incorrect application of the European coordination rules to try to avoid being subject to Belgian social security. The Belgian courts could, in the event of such abuse, decide that Belgian social security applies anyway. For example, if the Belgian court believes that there has been fraud or abuse of the European coordination rules and that the German employee is not posted to Belgium but in fact works under the authority of the Belgian third party, it can set aside the German A-1 document.
This new rule is controversial, especially in light of European law.
NETHERLANDS: Recent Change of Government Affected Country's Immigration Regulations
The recent change of government in the Netherlands has affected the country's immigration regulations.
A proposal to amend the Dutch Nationality Act will be withdrawn, the government announced on November 27, 2012. The proposal was sharply criticized, particularly its provisions to further reduce dual nationality. The current law already generally prohibits dual nationality, but applicants who are married to a Dutch person were exempt, as were Dutch nationals who acquire the nationality of another country and are married to a person of that nationality. Other measures that will not go through now include the introduction of an income threshold and a qualification requirement (at least two years of work experience in the Netherlands or at least two years of vocational qualification in the Netherlands).
Also, as of January 1, 2013, the financial penalties for non-compliance with the Employment of Foreigners Act (EFA) have increased drastically. Companies employing foreigners without the required work permit were previously fined € 8,000 per employee. This will be raised to € 12,000. In case of a second offense within five years, this amount is raised by 100% to €24,000 per employee (previously two years), or € 36,000 per employee if the EFA is violated for the third time within the five-year period. The company can also be shut down for up to three months if three offenses occur within five years, provided that the company has been warned in advance about the possibility of being shut down.
There is better financial news for family reunification applicants. Filing fees are reduced considerably as of January 2013. The reduction is a direct consequence of a long-pending complaint of the European Commission against the Netherlands. The Court of Justice of the European Union (CJEU) ruled on April 26, 2012 (C-508/10) that the government fee of € 401 for a European Community long-term resident permit is "excessive and disproportionate." The Dutch High Administrative Court followed this ruling in a judgment of October 9, 2012, on the Family Reunification Directive, applying the same principles of EU law as the CJEU. In response to this ruling, the Netherlands' State Secretary for Security and Justice announced that the government fee for family reunification would be reduced from € 1,550 to € 225 for visa nationals, and from € 1.250 to € 225 for visa-exempted nationals. The government fee for an EU Blue Card remains at € 750. Because the EU Blue Card is also based on an EU Directive, it could be argued that this amount is also "excessive and disproportionate."
In other news, some important restrictions on family reunification were introduced on October 1, 2012, of which the most remarkable was the abolition of conjugal partner immigration (with the exception of couples who are not allowed to marry according to the laws of the country where they live). This was introduced only days before the former government was replaced by the current one, and when the newly elected Parliament had already spoken out against such restrictions. This political gambit has not yet led to a clear announcement that the measures will be withdrawn or to continued opposition in Parliament. It remains to be seen if these measures will be maintained.
NETHERLANDS: Highly Skilled Migrant and EU Blue Card: Salary Threshold 2013
The salary thresholds for permits for highly skilled migrants (knowledge migrants) and EU Blue Card holders as of January 1, 2013, have been published. Foreigners aged 30 or over must earn a gross annual salary of € 52,010 to be eligible for a residence permit to work as a highly skilled migrant. For foreigners under the age of 30, the highly skilled migrant salary threshold is € 38,141. For graduates in the Netherlands, the threshold is € 27.336.
The salary threshold to acquire the EU Blue Card residence permit is € 60,952.
CHINA: Citizens of 45 Countries Now Allowed Visa-Free Transit Entry for Up to 72 Hours
As of January 1, 2013, Beijing and Shanghai are now allowing citizens of 45 enlisted countries visa-free transit entry for up to 72 hours.
Qualified foreign nationals include those who transit through Beijing International Airport, Shanghai Hongqiao International Airport, or Shanghai Pudong International Airport. Before arriving in China, they must qualify for entering the third country and must have purchased a plane ticket with confirmed seating to that country. The transit period in China can be no longer than 72 hours. Such foreign nationals may leave the airport during their transit period and engage in tourism within the boundary of their city of arrival. The 45 countries include the United States, Canada, the United Kingdom, Russia, France, Germany, Italy, Spain, Brazil, Argentina, Australia, Japan, and Singapore.
Foreign nationals who travel outside of their city of arrival or stay beyond 72 hours may face punishment. Beijing has announced that foreign nationals who, due to uncontrollable circumstances, need to stay longer than 72 hours or travel outside of Beijing must apply for a visa at the Department of Entry-Exit Administration of the Beijing Public Security Bureau. Foreign nationals who fail to apply for a visa under these circumstances may be punished according to the law and regulations related to illegal presence. Serious violations may result in restrictions on their future entries.
Beijing's and Shanghai's new policies are more lenient than China's current transit visa waiver regulation, which only allows foreign nationals wishing to transit through China up to 24 hours without a transit visa. They must have a valid connecting ticket with confirmed seating on an international flight and they must remain in the airport. The new program also expands Shanghai's existing transit visa waiver program, which exempts citizens of a shorter list of countries from the visa requirement if the travelers transit by air through Shanghai and stay for no more than 48 hours.
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text:
package org.apache.cassandra.db.tries;

import java.util.ArrayList;
import java.util.List;
import java.util.Map;
import java.util.Random;
import java.util.concurrent.ConcurrentLinkedQueue;
import java.util.concurrent.ThreadLocalRandom;
import java.util.concurrent.atomic.AtomicBoolean;
import java.util.concurrent.atomic.AtomicInteger;

import org.junit.Assert;
import org.junit.Test;

import org.apache.cassandra.io.compress.BufferType;
import org.apache.cassandra.utils.bytecomparable.ByteComparable;

import static org.apache.cassandra.db.tries.InMemoryTrieTestBase.VERSION;
import static org.apache.cassandra.db.tries.InMemoryTrieTestBase.generateKeys;

public class InMemoryTrieThreadedTest
{
    private static final int COUNT = 300000;
    private static final int OTHERS = COUNT / 10;
    private static final int PROGRESS_UPDATE = COUNT / 15;
    private static final int READERS = 8;
    private static final int WALKERS = 2;
    private static final Random rand = new Random();

    static String value(ByteComparable b)
    {
        return b.byteComparableAsString(VERSION);
    }

    @Test
    public void testThreaded() throws InterruptedException
    {
        ByteComparable[] src = generateKeys(rand, COUNT + OTHERS);
        InMemoryTrie<String> trie = new InMemoryTrie<>(BufferType.ON_HEAP);
        ConcurrentLinkedQueue<Throwable> errors = new ConcurrentLinkedQueue<>();
        List<Thread> threads = new ArrayList<>();
        AtomicBoolean writeCompleted = new AtomicBoolean(false);
        AtomicInteger writeProgress = new AtomicInteger(0);

        for (int i = 0; i < WALKERS; ++i)
            threads.add(new Thread(() -> {
                try
                {
                    while (!writeCompleted.get())
                    {
                        int min = writeProgress.get();
                        int count = 0;
                        for (Map.Entry<ByteComparable, String> en : trie.entrySet())
                        {
                            String v = value(en.getKey());
                            Assert.assertEquals(en.getKey().byteComparableAsString(VERSION), v, en.getValue());
                            ++count;
                        }
                        Assert.assertTrue("Got only " + count + " while progress is at " + min, count >= min);
                    }
                }
                catch (Throwable t)
                {
                    t.printStackTrace();
                    errors.add(t);
                }
            }));

        for (int i = 0; i < READERS; ++i)
        {
            threads.add(new Thread(() -> {
                try
                {
                    Random r = ThreadLocalRandom.current();
                    while (!writeCompleted.get())
                    {
                        int min = writeProgress.get();

                        for (int i1 = 0; i1 < PROGRESS_UPDATE; ++i1)
                        {
                            int index = r.nextInt(COUNT + OTHERS);
                            ByteComparable b = src[index];
                            String v = value(b);
                            String result = trie.get(b);
                            if (result != null)
                            {
                                Assert.assertTrue("Got not added " + index + " when COUNT is " + COUNT,
                                                  index < COUNT);
                                Assert.assertEquals("Failed " + index, v, result);
                            }
                            else if (index < min)
                                Assert.fail("Failed index " + index + " while progress is at " + min);
                        }
                    }
                }
                catch (Throwable t)
                {
                    t.printStackTrace();
                    errors.add(t);
                }
            }));
        }

        threads.add(new Thread(() -> {
            try
            {
                for (int i = 0; i < COUNT; i++)
                {
                    ByteComparable b = src[i];

                    // Note: Because we don't ensure order when calling resolve, just use a hash of the key as payload
                    // (so that all sources have the same value).
                    String v = value(b);
                    if (i % 2 == 0)
                        trie.apply(Trie.singleton(b, v), (x, y) -> y);
                    else
                        trie.putRecursive(b, v, (x, y) -> y);

                    if (i % PROGRESS_UPDATE == 0)
                        writeProgress.set(i);
                }
            }
            catch (Throwable t)
            {
                t.printStackTrace();
                errors.add(t);
            }
            finally
            {
                writeCompleted.set(true);
            }
        }));

        for (Thread t : threads)
            t.start();

        for (Thread t : threads)
            t.join();

        if (!errors.isEmpty())
            Assert.fail("Got errors:\n" + errors);
    }
}

redpajama_set_name: RedPajamaGithub


The artist Peter Carl Fabergé was born in France in May 1846 and lived in Russia until his death in September 1920.
The House of Fabergé is a jewellery firm founded in 1842 in St Petersburg, Imperial Russia, by Carl Gustav Faberge. Using the accented name "Fabergé", Gustav was followed by his son Peter Carl Fabergé in the family-run business. Ever since the firm has been famous for designing elaborate jewel-encrusted Fabergé eggs for the Russian Tsars along with a range of other work of high quality and intricate detail.
Most famous are the Imperial Fabergé Eggs: commissioned by Tsars Alexander III and Nicholas II as Russian Orthodox Easter gifts for their wives and mothers.
Fabergé's description of himself as an "artist-jeweller" is indicative of his approach to his creations. His best pieces show an unique alliance between the skills of the craftsman and the imagination of the artist. There can be no doubt that his decisions in matters of design were based on artistic impulse rather than on commercial considerations.
Galacia has created a fine jewellery collection that pays homage to the colour, craftsmanship and intrigue of Fabergé while retaining the brand's signature aesthetic.


text:
Kids-Friendly Phuket #4: Elephant Trekking with Siam Safari
Media Invite
When travelling with my monkies, I always try to look out for ways to give back to the local community - in whatever small ways that we can. Because not only does it provides educational opportunities for the kids, we are able to help certain communities in a non-commercial manner.
And during our holiday in Phuket, we found one such group - Siam Safari. At first glance, Siam Safari seems to be the usual tour operator hawking elephant trekking as its main selling point.
But after some research and being on one its tours, I know now that not only is it committed to conducting its elephant trekking ethically, it channels its funds towards elephant conservation and provides jobs to the local tribe there.
In fact, Siam Safari is the only Elephant camp which has been certified by the Royal Thai Government in Phuket and Southern Thailand, which guarantees that that its elephants are well taken care of, in good health and the camp run under sustainable environmental management. It has also been recently recognized as the best elephant camp in Thailand by the Ministry of Tourism and Sports by receiving the 'Excellent Elephant Camp' standard with the highest score of all the elephant camps evaluated in Thailand.
So with that peace of mind, we embarked on our half-day 4-in-1 Safari (with Lunch) Tour. We were picked up bright and early from our hotel and transported to the Elephant camp on top of a mountain at Chalong Highlands. The great thing about the tour was elephant trekking was not the sole highlight - it gave us the chance to learn more about Thai culture and rural life in the villages. And first up, the importance of coconuts to the Thai people.
The monkies saw for the first time, how a coconut was de-husked and then cracked opened with a spear. The coconut 'meat' was then grated out of the coconut and squeezed to make coconut milk.
They even got to take a few sips of coconut water from a freshly de-husked coconut and while Ale didn't quite enjoy it, both Ash and Ayd would have finished the entire portion had I not stopped them in time.
Moving on, we learnt how the coconut milk was then processed. After boiling it for few hours, coconut oil forms. The oil is then siphoned away while the brownish coconut residue is dried and used in Thai desserts.
Considering that the main food staple of the Thai people is rice, it was apt that our next station featured on how rice was processed.
We were escorted to a hut where a huge contraption that looked like a see saw with a leg-driven mortar and pestle. This was the machine that was used to separate the husk from the rice in the olden days and as Ayd will tell you, it was hard work!
Just imagine a person pumping the pestle for a good 30 minutes, before using a pan to separate the husked rice from the naked rice.
And after witnessing how tough it was to de-husk rice, the monkies declared they would never let a grain of rice go to waste from now on. It's amazing what a live presentation can do.
We were herded into a sheltered area next, where a coffee break awaited.
I know Thai coffee and tea is always sweeter than what we are generally used to but for some reason, I love it. Especially if it comes accompanied with some coconut pancakes as well.
And while we were sipping our drinks and chomping on pancakes, we were treated to the sight of a water buffalo ploughing rice back in the good old days.
It was like a trip to days gone by, and it definitely captivated the monkies as it was their first time seeing something as primitive as this.
Okay, so they were actually captivated by the fact that they were able to ride on a wooden cart pulled by a buffalo. Yes, me included.
A Thai curry cooking demonstration was next and while there was not much cooking done due to time constraints, we were shown the actual ingredients that go into Thai curry paste.
And what was a cooking demonstration without sampling? The boys bravely walloped a small portion of curry (with rice) while the wifey and I had second helpings. Okay okay, so I had three helpings.
As we trekked deeper into the forest, I noticed a huge area was planted with rubber trees, which was the premise of our next stop. We were given a demonstration in how rubber tree tapping is done. Did you know the best time to harvest the rubber sap is from 2am onwards? And the rubber tappers have to do it quickly before the sun rises because it will be too hot by then and the sap dries up. Definitely tough work so the next time you complain about your work, spare a thought for these rubber tappers.
The interesting bit for the kids was when they got to see first-hand how the rubber sap flowed out when the tree bark was cut. Plus the process that it undergoes in order to be made into the material we know as rubber.
We then moved on the baby elephants where we were given a glimpse on how they are trained. The baby elephants are not suitable to participate in the trekking for obvious reasons so in the meantime, they start their learning journey by obeying commands. Commands like picking up objects with their trunks, kicking a ball, painting pictures and even playing the harmonica!
And the paintings that the baby elephants churn out show after show are also available for purchase from the shop. A percentage from every painting will go directly to elephant conservation work. So the young elephants are actually doing their bit for other elephants too!
Of course, a photo opportunity with the 2 adorable baby elephants wouldn't hurt too.
And for 100 baht, the monkies got to feed them a basket of fruits.
Then, it was time for the main highlight of the tour.
Before our elephant trekking commenced proper, we were given a short briefing on how to mount and dismount from an elephant, and the rules to observe while riding on one.
And then we were off!
The mahouts, name given to the men who ride elephants, are all from the Karan tribe and they all live in the Safari area itself, working at the rubber plantation and looking after the elephants every single day. The Karen are regarded as the best handlers of elephants due to their relaxed temperament and their culture includes hundreds of years of experience working with and training elephants. In fact, the mahouts and their respective elephants are paired from a young age and it will often stay that way until the elephant or mahout retires.
The elephant trekking lasted for about 30 minutes as we trekked through the back paths of the grounds. Considering how huge and heavy the elephant was, coupled with the misconception that elephants are clumsy creatures, I was surprised by how graceful its gait was and the ride was not quite like a roller-coaster one that the wifey had originally feared.
The high point of the trek was when we arrived at a spot for an unobstructed view of Chalong Bay.
And all too soon, our elephant trek came to an end... much to the disappointment of the monkies. But we definitely learnt a lot about the elephants from our mahouts during the duration of the trek.
And of course, parting is such sweet sorrow.
At least the monkies got to feed their elephants another basket of fruits before bidding them farewell.
Then it was time to trek some more - this time by foot - to fill our own tummies.
Our tour ended with a delicious Thai buffet lunch, which would not win any food awards but decent nonetheless.
At least the view from the restaurant was superb.
The monkies then squealed in delight as they got the chance to hop onto a tractor as it brought us back to the tour bus carpark.
I guess it is safe to say the monkies thoroughly enjoyed the three hour safari tour at Siam Safari, with the highlight obviously being the elephant trek. But I believe for the boys especially, they have taken away much more than the element of fun. Coming from a modern city like Singapore, it was their first time witnessing demonstrations of coconut processing, rice farming and rubber tapping up close and I think it formed a rather deep impression on them.
Ale even drew a picture of her favourite moment of the Siam Safari tour!
As for Siam Safari, I love how it is making a conscious effort in making a difference to help elephant conservation in Thailand. They ensure that all of its elephants are regularly checked and monitored by elephant veterinarians, and also help the local community sustain by offering job opportunities at the camp.
If you are worried about the ethical aspect when it comes to visiting attractions that deal with animals, Siam Safari seems like a great way to find some balance between supporting tourism, the ethical treatment of animals and learning about a different culture.
Siam Safari's 4-in-1 Safari (with Lunch) Tour
Adult: THB2,300 | Child (4-11): THB1,500 | FREE for 3 years and below
Website: www.siamsafari.com/package_detail.php?id=85


Whether you are applying for funding, telling a family member about your research or engaging the public, your success will depend on how well you communicate.A flash talk is a challenge in which you have just three minutes to present a scientific concept or idea in an accessible manner. They are aimed at non-specialist audiences and usually happen in front of a live audience or a group of colleagues. There are lots of competitions for flash talks that you can get involved in, such as FameLab and Three Minute Thesis.
Ten tips by Djuke Veldhuis are presented for delivering a flash talk that is clear, concise and charismatic.


text:
Oak-Aged White Wines
The majority of white wines sold throughout the world are fermented and aged in stainless steel or other inert vessels, to preserve the fruit and other aromas and flavors. The grapes are harvested, fermented at a cool temperature, to retain their freshness, and then clarified and bottled, all in less than a year.
Winemakers may choose to barrel-ferment, or barrel-age a white wine in order to change the flavor profile, texture, and complexity of the wine. The white wine that is most often seen aged in oak is Chardonnay. Chardonnay is considered a non-aromatic grape, as its aromas are usually basic orchard fruit, like apple and pear, and perhaps some citrus notes. Barrel aging a wine grape like Chardonnay in new oak barrels will add tannins, impart flavors from the barrel itself, and introduce oxygen into the wine, changing its taste and texture.
Tannins in wine normally come from the skins and seeds which aren't usually involved in white winemaking. Aging a white wine in newer oak barrels will add tannins to the wine which acts as a natural preservative and helps the wine age longer.
Barrels are made from different species of oak. The two main sources for barrels in the world are France and the United States. Barrels from France and elsewhere in Europe are of species Quercus petrea, and barrels from America are Quercus alba. French oak tends to be denser, with closer spaced rings, which means that less flavor from the oak flavor and less oxygen gets imparted into the wine than from American oak. Wine aged in French oak tends to be more elegant, and those aged in American oak more assertive.
Flavors imparted from new French oak include vanilla bean, smoke, hazelnut, and savory spices. A new American oak barrel will add flavors of vanilla, coconut, fresh dill, and sweet spices to a wine. Once barrels have been used about four times, they are considered neutral in that they no longer have flavors left to impart into the wine. Neutral barrels still initiate changes to the wine within by reducing acidity and allowing small amounts of oxygen to come into the wine via the oak grain, since barrels are porous. To temper the amount of flavor imparted into the wine, a winemaker may age some wine in new and some wine in neutral barrels, and then blend them together before bottling.
White wines that will be aged in oak are sometimes fermented in oak. This allows the wine to be aged sur lie. Sur lie is a French term for lees aging. The lees are the leftover dead yeast cells that remain after fermentation concludes. While the yeast cells have fully completed their job, they are still going through a process of self-digesting, called autolysis. When wine is left in a barrel with the lees, along with periodically stirring them up into the wine called bâtonnage, the wine will pick up yeasty dough-like aromas and flavors and have an increased texture on the palate.
California Chardonnays were always thought to be oak-aged, but that is just one style of winemaking. What other white wines are aged in oak? Some Sauvignon Blanc from Sancerre in the Loire are oak-aged, but in large barrels which imparts fewer oak flavors, as less wine is in contact with the oak, due to the barrel size. White Bordeaux wines made from Sauvignon Blanc, Semillon, or a combination of both may see some time in oak. White wines from Rioja in Spain are oak-aged, usually in American oak. Chablis wines will often spend some time in oak to increase the texture and impart non-fruit flavors to the wine.
Oak aging in white wine mutes the fruit aromas, darkens the wine a bit due to oxidation, concentrates flavors, adds texture and weight, and potentially imparts flavors from the barrel itself. If you are interested in oak-aged white wines, look for barrel fermented, barrel aged, sur lie aging or descriptions that include vanilla, coconut, nuttiness, or spice in the tasting notes.


text:
COMMUNITY | Kathimerini English Edition Ethnarhou Makariou Avenue & 2, Falireos Street
COMMUNITY 19.03.2017
How millions in refugee funds were wasted in Greece
DANIEL HOWDEN *
TAGS: Migration, Analysis
For a story of waste and suffering, it's notable that some of the worst decisions in response to the refugee crisis in Greece were born of good intentions. An archipelago of some 50 small refugee camps was scattered over Greece in preference to concentrating asylum seekers in larger ghettos. As an idea it had merits. In practice it was disastrous.
Authorities still struggle to say how many camps there are. The Ministry of Migration Policy lists 39 but the UN says there may be more than 50. Many of these sites, which are in various states of closure, were clearly unfit for human habitation in the first place.
The choice to build so many of them multiplied infrastructure costs for things like sewage systems built on private property or remote sites that will serve no public purpose in the future. Meanwhile, the Public Power Corporation is building substations at sites that will likely face closure.
The European Commission and its humanitarian operations agency ECHO are expected to cease support for all but 10 of Greece's mainland camps in the near future. As the main donor, this will be decisive.
There is similar confusion over how many asylum seekers remain in Greece from the 1.03 million who entered in 2015-16. Again the ministry and the UN disagree, with the former saying 62,000 and the latter nearer 50,000. European officials say privately that both numbers are overestimates.
This shroud of confusion has contributed to a mess that will be remembered as the most expensive humanitarian response in history. Some $803 million flowed into Greece from the beginning of 2015, according to an investigation by Refugees Deeply, an independent reporting platform. The bulk of these funds were meant to be spent on services for the 57,000 refugees and migrants stranded in Greece when the borders shut one year ago. That translates to a rough cost per beneficiary of $14,000.
Nobody believes this has been money well spent. One senior aid official admitted that as many as $70 out of every $100 spent had been wasted. As anyone who followed the response in Haiti or Kosovo would affirm, the aid industry is inherently wasteful but this was excessive.
The scale of this became obvious from November onward when refugees were pictured in tents in the snow and it sparked a blame game. None of the actors emerge with much credit. The UN refugee agency played mute witness to failures in refugee protection for fear of offending its second largest donor, the European Union.
The European Commission was content to make grandiose statements that exaggerated the funding it had committed, while doing nothing to correct the mistakes it witnessed on the ground. It also made promises on asylum service assistance that were not kept. The bigger the mess in Greece, the greater the deterrent and the stronger the message to future asylum seekers not to come this way.
The most shrill voice in denying responsibility came from the Ministry of Migration Policy. Blame was deflected onto selfish hoteliers, troublemaking opposition politicians and local authorities. Most convincingly it was placed on foreign aid agencies, who Greeks were told were the ones who received all the funds. Unaccountable NGOs consuming astronomical sums resonated with many Greeks whose memories extend to past episodes in the Balkans.
The truth is that the Migration Ministry in its role as coordinator had final say over almost all major projects. The Commission channeled money through ECHO to international aid agencies but they still required government agreement on plans.
In so many instances this was the bottleneck. Foreign and Greek NGOs alike have found it impossible to get timely or sensible answers on urgent issues.
The functional Migration Ministry foreseen under Law 4375/2016, passed in April last year, has remained a paper pretense. The bureaucracy needed to tap larger programmatic European funds is only now being built.
For the crucial months building up to winter last year there was no government plan laying out what to do with the archipelago of sites it had insisted upon. The failure until last month to appoint competent and sufficient camp directors compounded the mismanagement. The conditions at Moria on Lesvos are an illustration of what the legal confusion and broken chain of command looks like in practice.
Greece must now make the best of its miserable assignment to be a buffer for an increasingly xenophobic EU. Any calculation that the harsh conditions allowed to prevail would defend the country against the return of asylum seekers from other member-states was proven wrong. The relationship between the government and its international partners has been soured by mistrust. And somehow a government that was, on paper at least, the most refugee friendly in Europe has presided over this. None of this was inevitable.
* Daniel Howden is a senior editor at Refugees Deeply, formerly with the Economist and the Guardian.
Cyprus marks anniversary of 1974 coup
Turkey marks 3rd anniversary of failed coup
Sanctuary for injured animals run by volunteers
Chrysochoidis inspects Lesvos migrant camps
Education reforms in the pipeline
Kids back in fire-razed Rafina playground
Fierce storms hit northern Greece, killing at least 7
Financial aid earmarked for Halkidiki, as death toll rises to seven
Turkey releases photos of ships off Cyprus in show of force
Mitsotakis takes over
Heat draws Greeks to the beach on election day
Greeks vote in first parliamentary election since bailout end
Greeks' varying expectations ahead of July 7 election
Heat wave closes Acropolis
Vartholomaios, Imamoglu meet in Istanbul
Two West Nile Virus cases confirmed in northern Greece
Islet off Naxos reveals signs of advanced ancient architecture
An uninhabited, seemingly drab landmass some 10 kilometers from the holiday island of Naxos in the Aegean, has yielded 4,600-year-old structures that provide evidence of ancient Greece's early history being far more complex than experts once believed.


text:
Pedro Pierluisi: "We must foster a culture of respect for all"
The candidate for governor for the New Progressive Party, Pedro Pierluisi, reacted to the controversy that has overshadowed social networks after the puppeteer Kobbo Santarrosa used a photo of Alexandra Lúgaro's daughter to criticize her.
"We all have to be part of the empowerment of our girls and young women," Pierluisi wrote in a tweet. "No person should violate the privacy and dignity of a minor, and we must always foster a culture of respect for all," he continued.
The former resident commissioner is the third candidate to react, after Juan Dalmau, from the Puerto Rican Independence Party, and César Vázquez, from Proyecto Dignidad, spoke out against the act committed by the La Comay production.
Puerto Rico Metro has requested a reaction or comment to Mega TV, broadcaster of the program, but at the time of this publication has not received a response.
It might interest you:
Previous Caravan in favor of Wanda Vázquez for governor arrives in Old San Juan
Next Man beats and bites his partner in Guaynabo


Celebrate the good times with this chalkboard inspired kit. Featuring black and white designs and chalkboard quotes, this kit makes your photos really pop! If you want to add variety to your Project Life scrapbook, the Good Times Value Kit is a great option. It gives you enough papers for part of a book and allows you to switch designs and themes whenever you choose.
Have a question about	the Good Times Value Kit? Ask us! Someone from FranklinPlanner or the community would be happy to help you!


Nikunj Jain and Ayush Varshney, founders of NashVentures were featured in Forbes 30 under 30 last month.
Nikunj Jain is now in police custody (under cryptocurrency scam charge) and Ayush Varshney is absconding.
What due diligence goes into these 30 under 30 programs (link), if there is one?
What's the ongoing rate, if there is one for these awards?


text:
Irvin David Yalom (Washington D. C., 13 de junio de 1931) es catedrático de psiquiatría en la Universidad Stanford y psicoterapeuta. Ha escrito, además, numerosos ensayos y novelas.

Biografía
Hijo de inmigrantes judíos polacos. Tras graduarse en medicina en la Universidad de Boston en 1956, completó su internado en el Hospital Monte Sinaí en Nueva York y su residencia en la clínica Phipps del Hospital Johns Hopkins, en Baltimore. Terminó sus estudios en 1960. Tras dos años de servicio al ejército en Honolulu, Yalom comenzó su carrera académica en la Universidad Stanford. Fue designado a la facultad en 1962 y en 1968 le fue concedida la titularidad.

Se hizo famoso cuando su obra Love's Executioner and Others Tales of Psychotherapy, publicada en 1989, alcanzó la lista de los libros más vendidos en Estados Unidos. Su primera novela de ficción fue El día que Nietzsche lloró (1992), la cual estuvo en el primer puesto de ventas en Israel.

Es considerado uno de los principales representantes de la psicoterapia existencial en el continente americano.

Estuvo casado con la historiadora, escritora y feminista Marilyn Yalom, hasta el fallecimiento de esta.

Obra

Novela y relato
 1974, Every Day Gets a Little Closer
 1989, Love's Executioner and Other Tales of Psychotherapy
 1992, El día que Nietzsche lloró
 1996, Lying on the Couch
 1999, Momma and the Meaning of Life
 2005, The Schopenhauer Cure
 2005, I'm calling the police! A Tale of Regression and Recovery
 2012, The Spinoza Problem
 2015,  Creatures of a Day - And Other Tales of Psychotherapy,

Ensayo
 1970, The Theory and Practice of Group Psychotherapy  (5th edition 2005)
 1980, Existential Psychotherapy
 1983, Inpatient Group Psychotherapy
 1996, The Yalom Reader
 2001, The Gift of Therapy: An Open Letter to a New Generation of Therapists and Their Patients
 2008, Staring at the Sun: Overcoming the Terror of Death
 2017, Becoming Myself: A Psychiatrist's Memoir

Filmografía

 2003, Flight from Death (dirigida por Patrick Shen, interpretada por Ron Leifer, Robert Jay Lifton, Merlyn Mowrey y Sheldon Solomon e Irvin D. Yalom).
 2007, When Nietzsche Wept (dirigida por Pinchas Perry, interpretada por Ben Cross, Armand Assante, Katheryn Winnick).
 2014, Yalom's cure (dirigida por Sabine Gisiger).

Premios
 1974, Premio Edward Strecker por su significativa contribución al campo de los pacientes psiquiátricos, por la Universidad de Pensilvania, Escuela de Medina, Departamento de Psiquiatría.
 1976, Premio Foundation´s Fund por la investigación en psiquiatría, por la Asociación Estadounidense de Psiquiatría.
 1977, Premio al Miembro del Centro de Estudios Avanzados en las Ciencias de la Conducta.
 1987, Premio al Miembro Investigador de la Fundación Rockefeller (Bellagio, Italia).
 1992, Premio de Oro del Commonwealth Club por la mejor novela de ficción (El día que Nietzsche lloró) por el Commonwealth Club de California.
 2001, Premio Oskar Pfister de la Asociación Estadounidense de Psiquiatría por sus contribuciones al estudio de la psiquiatría y de la religión.
 2009, Premio Internacional Sigmund Freud de Psicoterapia de la ciudad de Viena, Austria, por la Asociación Mundial de Psicoterapia.

Referencias

Edición en español
La mayor parte de su obra ha sido publicada por Ediciones Destino:
 Memorias de un psiquiatra, Ediciones Destino, 2019
 El don de la terapia, Ediciones Destino, 2018
 El problema de Spinoza, Booket, 2018
 Criaturas de un día, Booket, 2018
 La cura Schopenhauer, Ediciones Destino, 2017
 El día que Nietzsche lloró, Booket, 2013

Otras obras:
 Guía breve de psicoterapia de grupo, Ediciones Paidós, 1996

Enlaces externos
 Sitio web de Irvin Yalom (en inglés)
 American Group Psychotherapy Association (en inglés)

Escritores de Estados Unidos del siglo XX
Psiquiatras de Estados Unidos
Alumnado de la Universidad de Boston
Profesores de la Universidad Stanford
Escritores judíos
Judíos de Estados Unidos
Premio Oskar Pfister
Nacidos en Washington D. C.

redpajama_set_name: RedPajamaWikipedia


These are my shots done for an animation project under the direction of pixar artist Bret Parker at CCA. The animation was made for the Marine Mammal Center and tackled the problem of climate change in an entertaining way. Work was done in Toonboom and Flash.
During the busy semester of Fall 2015, I managed to work on a group project with Pixar animator and artist Bret Parker. It was an Animation made for the Marine Mammal Center. I animated a few shots in ToonBoom and Flash over the course of a semester.
Animation came out great, and the center was very happy with what we produced as a group of CCA 2D-animation students.
We visited the center after finishing the Animation. We displayed all the pre-production work and did some seal drawing workshops for kids.
One of the drawings I made for display.


text:
Pictorial Map of the Republic of Panama with the...
Stock# 63469rc
Clark Teegarden & John F. Herman
Pictorial Map of the Republic of Panama with the Canal Zone
Seattle / 1940
Striking large decorative map of Panama.
Includes two insets: "Canal Zone and Vicinity" and "Panama The Crossroads of the World".
Rich coloring, striking flag border, a particularly sophisticated example of a pictorial map.
"'With a partner in the 1940s he (Clark Teegarden) designed pictorial maps that in their era were quite popular, a Washington state map and a Panama Canal Map, the major reflections of his talent for painting,' said his son, John Teegarden of Seattle. 'They're neat because they have little illustrations for places in the state and in Panama. The Panama Map in particular was quite a success, and they got royalties. There were so many service and Canal Zone personnel there, and it was kind of a souvenir.'" (from Teegarden's obituary in the Seattle Times).
The pictographs highlight the animal life and characteristics of the area, including "the annual Zebra Swallowtail migration across Panama...," "old Indian gold mines," "the waters of Panama (Indian word meaning abundance of fish) are a mecca for game fishermen." The white sails of the yachts in the right foreground are used for charts of Weather Comparison,
History Briefs (with information to July 9, 1941), and the Legend which includes such as Railroads, present locks and new third locks.
Antique Maps / Caribbean & Central America / Central America
Novae Hispaniae, Chili, Peruviae, et Guatimalae Littorae Apud F. de Wit
Nice example of this sea chart of the western coastlines of South and Central America, published by Louis Renard.
West Indische PASKAERT waerin de graden der breedde over weder zijden vande middelijn wassende soo vergrooten dat die geproportioneert sijn tegen hunne nevenstaende graden der lengde; Vertonen (behalven Europaes zuydelijcste) alle de Zeekusten van Africa en America. . . bij Ioannes Loots.
"A scientific and artistic document of the first order" -- One of the most important sea charts of the 17th century.
Striking full color example of this wonderful decorative map of Central America, including Guatemala, Honduras, El Salvador, Nicaragua and "Mosquito Territory."
Map of Central America Including The States of Guatemala, Salvador, Honduras, Nicaragua and Costa-Rica, The Territories of Belise & Mosquito . . . Additions from the latest Surveys of the Admiralty, S. Moro. Col. Lloyd, Garella, Codazzi, Hughs, Childs . . . Railway Survey in Honduras . . . 1856
Fine example of the second edition of this finely detailed map of Central America, prepared by John Baily, who served as a surveyor of Nicaragua and was an early proponent of a canal across Central America, published in London by Trelawney Saunders.
Detailed map of Central America, colored by country and states, with insets of the Railroad across the Isthmus of Darien and The Isthmus of Tehuantepec.
Bowles's New One-Sheet Map of the West Indies, Laid Down from the Observations of Celebrated Geographers . . .
Large detailed map of Florida and the Caribbean, published by Bowles & Carver.


text:
Feedback Catan Universe
AI logic: over-reaching its cards / and failing
AI logic: over-reaching its cards / and failing browsing
MonkeyZ
last edited by MonkeyZ
TLDR: why does the AI over reach its resources rather than build where it is, losing a key position to an opponent who clearly will take the spot they are competing for on their next turn !?
OK, So the AI builds a road towards a a key spot, in order to block another player also trying to build there.
So, it could build a settlement right where it is, not the ideal spot, but effectively blocking the other player from building the next spot over, or it could build one road over and build exactly where the other player wants.
The AI as expected attempts/makes a few trades, has enough to build right there... but nope, it builds one more road over, then tries to make a few more trades, but either doesn't have enough to build a settlement, or can't get the trade it needs to build.
Why is the AI so greedy/stupid. It should have tried all the trades before building that road, if it had enough then build road and take the spot, if it doesn't, build where it is. Rather, it moves prematurely, over-reaches it's resources or ability to trade, and then loses the opportunity to build / and loses the opportunity to block.
This was extra frustrating for me, because I needlessly traded resources I needed, expected the AI would block the other player (who was way to strong)... but nope, it failed, because it is stupid and for some reason isn't programmed in simple logical decisions (do what you can / don't try to build to a spot you don't have enough for, and will clearly be beaten to by your opponent)
Does this need a screenshot !? Please fix the AI. It can't be counted on like humans can with strategic trades/blocking players, and is one of too many reasons the AI unbalances the game. [It's not like I'm even asking for the AI to predict future outcomes, just see that what it's trying to do obviously wont work in the immediate next round]
This will not be fixed any time soon. The developers are probably working on another expansion that will also have the same issues. I guess they try to get GoT Catan out by the time the last season begins...
@Stroom
@Stroom Well, I figure if I can just roll out problematic scenarios, they can ate least build test cases. Although it's not really clear if agile approaches are in use
I didn't know there was a GoT expansion/version... interesting! Ideally they'd roll in critical and/or a block or related bugs/enhancements with each expansion release, but I don't know how much capacity they have.
katan.io is moving a lot faster, at least based on the bi-weekly bug fix reports.
@Stroom Even a bit of time fixing minor bugs and/or small features would certainly go a long way to increase confidence (although I know many bugs have deep implications, and many platforms makes bug fixes a challenge) If Katan.io is web based, that's a more focused platform (I'll check it out!)


According to Emergency Management B.C. and as informed by the media, a large earthquake occurred off the Coast of Central Chile, on September 16. The National Tsunami Warning Center is currently analyzing the potential impacts along the West Coast of North America. At this time, no zones of coastal British Columbia are at risk from this event.
Huu-ay-aht First Nations has an Emergency Preparedness Plan. If you have any questions on the subject, contact Amelia Vos, the Nations' Environmental Technician, at 250.728.3414 or via email amelia.v@huuayaht.org.
Please consider this event a reminder to be ready for earthquake and tsunami alerts. Do you have a grab-and-go kit ready? Does your family know the evacuation plan?
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"In the 1930s a physician named Francis M. Pottenger, Jr. undertook a series of studies, which lasted 10 years and involved over 900 cats, to ascertain the effects of a raw food versus a cooked food diet on a cat's physiology. All the cats were fed either milk or meat or both. Some were fed raw meat and raw milk, some were fed cooked meat and raw milk, and others cooked meat and cooked milk. All the cats receive cod liver oil. Pottenger kept meticulous records which met the most rigorous scientific standards of the day. The studies, while initially well received, have unfortunately been much criticized in the ensuing years, yet no one has attempted to replicated them in order to disprove the results.
These results were both profound and enlightening. The most startling finding was that the cats fed almost exclusively cooked meat (with one-third their diet consisting of raw milk) did not survive beyond the third generation. They could not reproduce. There seems to be a parallel in our human family today. As reported by John Robbins in Diet for a new America (Stillpoint Publishing, 1987), "Tests done at several major universities have found nearly 25 percent of today's college students are sterile." This finding is substantiated by the increased prevalence of fertility clinics, which are trying to fulfill the needs of couples who cannot produce offspring on their own..."


As All Hazards Readiness consultants we have been following the Proposed Rule CMS-3178-P with interest since it was slipped into the Federal Register during the holiday season (December 27, 2013). Being a third party that is largely in the middle of the issues between Providers and the Public, we see our role as one that helps to prevent loss of life and also ensures clients are not exposed to liability for non-compliance, and not overly burdened with redundant regulation and cost. In addition to reviewing the Public Comments, we contacted Congressional and Senate representatives for comments to determine the level of concern for the issue among elected officials. Below are our verbatim Public Comments to CMS as of the cut-off date of the 31st. Our comments were based on about 220 comments that were posted by that deadline. Based on a large group of Public Comments from major organizations that were posted in the three days following the deadline, our opinion on a few issues has been reconsidered and will be reflected in upcoming posts as we follow this Proposed Rule through the Final Phase and then into implementation.
As background to our comments on the proposed rule we want to stress that the most important objective is for the Healthcare Sector to be able to fulfill its' expected role in the National Response Framework (NRF) in the event of natural and manmade disasters. This is an important point because even with the assumption that a hospital will provide a safe locus of care from a clinical perspective, we cannot assume that the facility will be able to continue operations in situ or after a large scale evacuation – continuity of operations is the key objective of All Hazards planning. The healthcare threat profile is dynamic and is apparently becoming increasingly dangerous; with more frequent and robust natural disasters, evolving infectious diseases, deadlier manmade events in a more hostile global environment.
The issues are not new; President Reagan was the first in the modern era to issue Presidential Directives to upgrade the readiness posture away from the Cold War threats to CBRNE (Chemical, Biological, Radiological, Nuclear and Explosive), largely to account for WMD materials falling into the hands of non-state actors as the USSR disintegrated. The World Trade Center attack #1 and the Oklahoma City Bombing demonstrated that non-state actors using unconventional methods were the threat.
The ultimate manifestation of this threat profile was the Al Qaeda terrorist attacks of September 11,2001, striking at the heart of America's Financial, Defense and Transportation systems, permanently altering US domestic and international safety and security posture, and effectively goading the country into two wars and trillions in deficit spending for the sake of security.
In an attempt to ready the Healthcare sector in a post-9/11 world, the newly-formed Department of Homeland Security (DHS) decided to treat the Public and Private healthcare sectors as similar in terms of emergency management requirements, which in retrospect might not have been the best approach given the Private Sector's long history of avoiding and delaying regulation, i.e., maintaining inventory of PPE, seismic upgrading in earthquake zones, installing redundant utilities systems in flood zones, securing radiological materials that are vulnerable to theft and in-place detonation, etc.
While Federal resources could be and were mandated to achieve a higher level of readiness, the remaining 90% of US healthcare capability (in the Private Sector) could not be enticed or coaxed into meeting a higher level of readiness. Health Sector Emergency Readiness became a hot potato issue, passed back and forth between DHS, DHHS, and CMS, with no ultimate authority in a position to enforce a standard of preparation. The private sector dragged its feet and even DHS could not entice hospitals to adopt the suggested guidance despite Federal Grant programs and resources. The Joint Commission (TJC), a virtual monopoly for the past thirty years, is the giant in the Accreditation market. They have filled the readiness vacuum by accrediting hospitals to operate according to Standards that CMS has until now, deemed satisfactory to meet the Conditions of Participation (CoP).
This hurricane came into the Gulf Coast with winds of up to 174MPH, causing catastrophic damage as the levies failed and flooded a large section of New Orleans, LA. It is estimated that the storm caused over 1,800 lives lost, and brought all public and local government services to a standstill in NOLA.
Healthcare casualties numbered over 330; patients expired without electricity to operate life-support equipment, some drowned as water rose above the level of their beds, temperatures climbed over 100 degrees in flooded hospitals and nursing homes. Critical shortages of food, water and medicine prevented care and forced caregivers to make life and death decisions between patients. A FEMA-financed test of the Healthcare Emergency Readiness system (Exercise PAM) predicted a mirror image of the flooding and devastation, including the breach of the levies that isolated healthcare facilities in six foot flood waters that prevented re-supply. Despite these dire warnings, many hospitals did not remove emergency generators and critical supplies (Food, Water and Medicine) from below the flood plain. The decision was made to Shelter in Place rather than evacuate; sealing the fate of the most fragile of the inpatients. All major NOLA hospitals were accredited by TJC or another accrediting body. Post Katrina there have been many other examples of hurricanes that have caused loss of life and property; Rita, and Wilma to name a few.
Hurricane Sandy produced sustained winds of 115MPH and was named on October 22, 2012. The super-storm hit Cuba hard on the 23rd would make landfall in the New Jersey/New York area on or around the October 29. President Obama preemptively declared several states Emergency Areas on the 28th after governors declared States of Emergency on the 26th. In New York City, despite continuous estimates of record flooding, the decision to Shelter in Place was made at many large hospitals in the storm's path.
NYU's Langone was forced to backtrack and evacuate a reported over 200 patients down darkened stairwells as the back-up generators failed. At Belleview, the only Level 1 Trauma Center in the Lower Manhattan area, the National Guard had to support the evacuation of that hospital as its' back up electricity system flooded out. Several other facilities were forced to evacuate and many took weeks or months to re-open. The complete rebuilding program at Langone will come with a share of public money; another large-scale public bailout.
We can only speculate that Hurricane Sandy was the last straw for CMS, but given the billions of taxpayer dollars that have gone to NYC since 9/11 to ensure readiness, the reluctance of the industry to adopt voluntary guidelines and the inability of existing accreditation mechanisms to drive change; it would not come as a surprise.
A) Several organizations acting on behalf of members who receive medical services, such as AARP, feel the regulations are both justified and beneficial, while those who advocate on behalf of members who provide services, such as ambulatory surgical services or organ transplant, argue that they are different and should not be held to any specific role beyond their existing scope of services to assist the community in public disasters.
B) The majority of hospital comments come from an Engineering and Facilities perspective and many argue that the new monthly generator testing is wasteful and could actually decrease readiness for technical reasons that involve running the generators using a full load more than once a year.
C) Many hospitals also feel that current NFPA Life Safety Codes overlap with the new CMS requirements, as do those from TJC for Emergency Management and that redundancies should be eliminated, producing a more specific set of standards.
D) Another major point of concern for hospitals was the expectation of self-sustained operations, requiring availability of Food, Potable Water and Medicine to support a major patient surge in case of disaster.
E) In terms of the ability to adopt these requirements, suggestions were made to phase in certain requirements, waive overly onerous requirements depending on applicability of the business model, and grandfather some requirements in for existing facilities and apply them to new construction.
Our position on the proposed rule is somewhere in the middle of what is best for patients and what is possible for providers; with the caveat that corporate financial risk management practice should not apply here – hedging profit risk against a human life is always wrong. And as mentioned at the beginning, the objective here is to be able to provide the safest possible care in the case of disasters.
A) It will be up to CMS to determine the level of readiness that Ambulatory Surgical Centers provide in case of disasters; it is difficult to force participation for those who would close shop and send employees home during a disaster but at the same time taking out all the surgical capacity they represent seems like a waste. We suggest that better incentives be provided for ASCs to operate during emergencies. More detailed guidance and definition is probably required for organ transplant providers as well. Home Health Provider Guidelines should also be reviewed in our opinion, warranting that there is some accountable entity, whether family or third party, to ensure the safety of the patient in case of All Hazards scenarios.
B) Given the repeated role of flooded generators in evacuations and fatalities, we would suggest that the placement of generators and related equipment required for back up electricity be placed well above the flood plain as a CoP. If the hospital is in a flood prone area and the back-up electricity supply is below the flood plain, it should result in immediate sanction.
C) We also believe that having the whole plan focus on providing patient care would be a step in the right direction. This requires a redefinition of Emergency Management where senior leadership is engaged and responsible for a holistic plan that combines clinical capabilities, all forms of patient care and facilities preparation.
D) A key issue is that healthcare facilities are different than other buildings based on their role, materials and populations. A good Healthcare All Hazards Vulnerability Assessment and Plan will incorporate many sources of guidance to close gaps at the geographic and individual facility level, including NFPA, TJC, State Regulations, OSHA, FEMA, (State)EMA and many others. In addition, there is no single plan that can address the wide range of providers; one size does not fit all. NFPA has significantly tightened Emergency Readiness requirements in the latest guidance and may be the best guidance to cover life safety and certain emergency management provisions. This needs to be integrated with healthcare-specific issues such as in chemicals, gases, biohazards, crowd control, inventory protection and others to create a holistic plan. We have found that one of the biggest gaps tends to be in the external relationships the hospital maintains, making these areas a critical part of the contingency planning.
E) We believe it is not unreasonable to expect a hospital to plan and prepare for a large increase in capacity in a disaster, with Katrina as a worst case scenario, emergency power, food, water, medicine and basic medical consumables were in short supply from the beginning. Some of these requirements seem overly onerous to small hospitals in the areas where substantial retrofitting would be required. Having independent sewage for example, should probably be reviewed on a case by case basis with waivers or grants in some cases.
F) This rule is going to be difficult to implement for many providers, especially considering other important reforms impacting them. We suggest it be phased in over the course of three years, with certain waivers for infrastructure improvements that are not feasible for some small providers.
On a final note, we contacted over a hundred representatives in Congress and the Senate. All leadership, including subcommittee heads in Healthcare, Rules, Homeland Security, Aging, etc. We sent several hundred faxes, emails and phone messages in three waves. We got less than a 1% return rate, and within those no real follow up. Even those who stand up and thump their fists loudest for reform, regardless of party, were nowhere to be found for public quotes on this issue. Go Figure.


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text:
Human topoisomerase I inhibition: docking camptothecin and derivatives into a structure-based active site model.
Biochemistry. 2002 Feb 05; 41(5):1428-35.B
Human topoisomerase I (top1) is an important target for anti-cancer drugs, which include camptothecin (CPT) and its derivatives. To elucidate top1 inhibition in vitro, we made a series of duplex DNA substrates containing a deoxyadenosine stereospecifically modified by a covalent adduct of benzo[a]pyrene (BaP) diol epoxide [Pommier, Y., et al. (2000) Proc. Natl. Acad. Sci. U.S.A. 97, 10739-10744]. The known orientation of the hydrocarbon adduct in the DNA duplex relative to the top1 cleavage site, in combination with a top1/DNA crystal structure [Redinbo, M. R., et al. (1998) Science 279, 1504-1513], was used to construct a structure-based model to explain the in vitro top1 inhibition results obtained with adducted DNA duplexes. Here we experimentally determined that the lactone form of CPT was stabilized by an irreversible top1/DNA covalent complex. We removed the BaP moiety from the DNA in the published model, and docked the lactone forms of CPT and derivatives into the top1/DNA active site cavity. The docked ligands were minimized, and interaction energy scores between the ligands and the top1/DNA complex were determined. CPT docks perpendicular to the DNA backbone, projects outward from the major groove, and makes a network of potential H-bonds with the active site DNA and top1 residues, including Arg364, Lys532, and Asn722. The results are consistent with the known structure-activity relationships of CPT and derivatives. In addition, the model proposed a novel top1/N352A "resistance" mutation for 10-OH derivatives of CPT. The in vitro biochemical characterization of the top1/N352A mutant supported the model.
Laco GS
Laboratory of Molecular Pharmacology, Division of Basic Sciences, National Cancer Institute, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
Collins JR
Luke BT
Kroth H
Sayer JM
Jerina DM
Pommier Y
Binding SitesBinding, CompetitiveCamptothecinDNADNA Topoisomerases, Type IEnzyme InhibitorsHumansHydrogen BondingIrinotecanModels, MolecularMolecular ConformationNucleic Acid HeteroduplexesStructure-Activity RelationshipSubstrate SpecificityThermodynamicsTopoisomerase I Inhibitors
Laco, Gary S., et al. "Human Topoisomerase I Inhibition: Docking Camptothecin and Derivatives Into a Structure-based Active Site Model." Biochemistry, vol. 41, no. 5, 2002, pp. 1428-35.
Laco GS, Collins JR, Luke BT, et al. Human topoisomerase I inhibition: docking camptothecin and derivatives into a structure-based active site model. Biochemistry. 2002;41(5):1428-35.
Laco, G. S., Collins, J. R., Luke, B. T., Kroth, H., Sayer, J. M., Jerina, D. M., & Pommier, Y. (2002). Human topoisomerase I inhibition: docking camptothecin and derivatives into a structure-based active site model. Biochemistry, 41(5), 1428-35.
Laco GS, et al. Human Topoisomerase I Inhibition: Docking Camptothecin and Derivatives Into a Structure-based Active Site Model. Biochemistry. 2002 Feb 5;41(5):1428-35. PubMed PMID: 11814334.
TY - JOUR T1 - Human topoisomerase I inhibition: docking camptothecin and derivatives into a structure-based active site model. AU - Laco,Gary S, AU - Collins,Jack R, AU - Luke,Brian T, AU - Kroth,Heiko, AU - Sayer,Jane M, AU - Jerina,Donald M, AU - Pommier,Yves, PY - 2002/1/30/pubmed PY - 2002/2/20/medline PY - 2002/1/30/entrez SP - 1428 EP - 35 JF - Biochemistry JO - Biochemistry VL - 41 IS - 5 N2 - Human topoisomerase I (top1) is an important target for anti-cancer drugs, which include camptothecin (CPT) and its derivatives. To elucidate top1 inhibition in vitro, we made a series of duplex DNA substrates containing a deoxyadenosine stereospecifically modified by a covalent adduct of benzo[a]pyrene (BaP) diol epoxide [Pommier, Y., et al. (2000) Proc. Natl. Acad. Sci. U.S.A. 97, 10739-10744]. The known orientation of the hydrocarbon adduct in the DNA duplex relative to the top1 cleavage site, in combination with a top1/DNA crystal structure [Redinbo, M. R., et al. (1998) Science 279, 1504-1513], was used to construct a structure-based model to explain the in vitro top1 inhibition results obtained with adducted DNA duplexes. Here we experimentally determined that the lactone form of CPT was stabilized by an irreversible top1/DNA covalent complex. We removed the BaP moiety from the DNA in the published model, and docked the lactone forms of CPT and derivatives into the top1/DNA active site cavity. The docked ligands were minimized, and interaction energy scores between the ligands and the top1/DNA complex were determined. CPT docks perpendicular to the DNA backbone, projects outward from the major groove, and makes a network of potential H-bonds with the active site DNA and top1 residues, including Arg364, Lys532, and Asn722. The results are consistent with the known structure-activity relationships of CPT and derivatives. In addition, the model proposed a novel top1/N352A "resistance" mutation for 10-OH derivatives of CPT. The in vitro biochemical characterization of the top1/N352A mutant supported the model. SN - 0006-2960 UR - https://www.unboundmedicine.com/medline/citation/11814334/Human_topoisomerase_I_inhibition:_docking_camptothecin_and_derivatives_into_a_structure_based_active_site_model_ L2 - https://doi.org/10.1021/bi011774a DB - PRIME DP - Unbound Medicine ER -
Binding, Competitive
DNA Topoisomerases, Type I
Hydrogen Bonding
Models, Molecular
Molecular Conformation
Nucleic Acid Heteroduplexes
Structure-Activity Relationship
Substrate Specificity
Topoisomerase I Inhibitors
Molecular modeling studies of the DNA-topoisomerase I ternary cleavable complex with camptothecin.
Evaluation of two models for human topoisomerase I interaction with dsDNA and camptothecin derivatives.
Action models for the antitumor drug camptothecin: formation of alkali-labile complex with DNA and inhibition of human DNA topoisomerase I.
Analysis of human topoisomerase I inhibition and interaction with the cleavage site +1 deoxyguanosine, via in vitro experiments and molecular modeling studies.
An ab initio quantum mechanics calculation that correlates with ligand orientation and DNA cleavage site selectivity in camptothecin-DNA-topoisomerase I ternary cleavage complexes.
Interaction of an alkylating camptothecin derivative with a DNA base at topoisomerase I-DNA cleavage sites.
Molecular determinants of topoisomerase I poisoning by lamellarins: comparison with camptothecin and structure-activity relationships.
Homocamptothecin, an E-ring-modified camptothecin analogue, generates new topoisomerase I-mediated DNA breaks.
Exploring DNA topoisomerase I ligand space in search of novel anticancer agents.
Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex.


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At least 11 people, among them 5 children, were detained in Turkey's Edirne province while they were on their way to escape to the Greece, state-run Anadolu news agency reported Tuesday.
Police, upon an earlier tip-off, stopped a car near Edirne's Yenikadın village and captured 6 adults along with 5 children who are reported to have been on their way for an illegal entry to Greece.
Police also caught three Bulgari nationals who are claimed to have supported those would-be escapers during their journey to Greece and who were later put in pretrial detention.
Anadolu said two of the 6 adults detained in the car had had outstanding arrest warrants over their ties to the Gulen movement.
The six suspects were referred to the court for arrest while the children were sent to their relatives, according to Anadolu.
The government accuses the movement of masterminding the coup while the latter denies involvement.