Earlier this year, architect Ken Shuttleworth stood in front of a group of engineers at the CIBSE Awards dinner and branded members of his own profession as 'arrogant' and 'egotistical'.
With tongue firmly in cheek, his outburst went down a treat with a well-lubricated audience of building services and environmental engineers. It gathered a lot of outraged comment in the press, either genuine or mock outrage depending on your point-of-view. But I think Ken's point was that architects and engineers have to work more closely and equally to deliver the shared goal of better buildings - buildings that work.
Max Fordham and the Architects Journal brought six experts together to discuss 'beautiful engineering' at the RIBA. I was fortunate to share the round table with the likes of Jim Heverin from ZHA, Grimshaw's Andrew Whalley, structural engineers Les Postawa from Thornton Tomasetti and Jane Wernick, as well as my colleague Hareth Pochee. This is the third in our Round Table series.
There's broad agreement that we achieve better results when architects and engineers collaborate early in the design process. But why is such a distinction made between the two in the first place. Hareth contends that we are all designers - we all use science to design things. Science isn't just equations and formulas. It is reasoning as well, and architects are excellent in the application of reasoning to the design of buildings.
I worked closely with Les Postawa from Thorton Tomasetti and the team from Zaha Hadid on MAXXI, the Museum of 21st Century Art in Rome. That kind of relationship begins with a clear understanding of what we are all trying to achieve. Our engineering is reacting and responding to the architecture, and in a similar way ZHA's architecture is doing likewise for the art. What we end up with is beautiful engineering discreetly employed in wonderful architecture that elevates the artwork.
Ken Shuttleworth labelled his architectural cohort 'arrogant and egotistical' with a big grin on his face. But we work hard for a genuinely collaborative relationship with everyone on the design team, clients and contractors alike. We firmly believe that if Max Fordham can be involved in a project earlier in the design process and later, post-completion, we achieve better results.
You can read the 'Beautiful Engineering' Round Table here. You'll also find the previous editions on 'Sustainability' and 'Collaboration' on the same page. I hope you enjoy!


Everything is reactive. Your application reacts to the click of a button, an incoming message. But also to the result of a database query. Between these events, you want to process other tasks. Being reactive needs a complete approach. Let's look at the state of reactive programming in Java. Which frameworks are available? Do we have everything to build enterprise grade reactive applications? How to we produce readable and maintainable code? This is the complete overview of reactive programming in Java. We will cover the following libraries: RxJava, Project Reactor, Akka streams.


for this project, i was commissioned to design the identity and a lookbook for my friend Cherokee's brand CWY, as part of her university work as a fashion student.
the theme chosen for the brand is "kendo", and there is a definite focus on dark colours and minimalism, something that i wanted to convey in the layout.
for the logo, i decided to go with a bold, assertive serif-style custom font.


text:
The importance of keeping connected in a remote world
By Hema Bakhshi
Where and how we work is changing
The workplace is transforming in ways which we previously could not have imagined. Technology is now connecting people with opportunities in a remarkable way as we see an increase of decentralised work alongside an increase in decentralised workers. The observations on portfolio careers, the gig economy and the liquid workforce are endless, most of which describe the organisational and societal impact of the shifting construct of work. For many, this notion is no longer just an idea or concept, but a reality of a more flexible approach, which is largely owned and created by the individual themselves.
Physically, the environments within which we work are evolving. Glass towers and hundreds of clinical grey cubicles are being gutted and redesigned into open, bright, engaging spaces.
The shared office illustrates how organisations are shifting from owned or leased and centralised facilities to purpose-built hubs, housing state-of-the art meeting places and technologies. A transient environment, providing cost advantages, just-in-time services, and flexibility.
The remote office gives some interesting insight into how some are replacing the daily commute with teleworking. The adoption of liberating technology means for many, the daily, sweaty, London underground experience could be a thing of the past, not to mention the flexibility to manage our increasingly demanding lives.
In some instances, a global office presents previously unobtainable possibilities. Perhaps the best skills for a project are not in physical reach at all. Our future colleagues may not just be diverse in terms of background and skills, but also geographic location. Could the best person for the job be sat in a tiny remote village on a completely different continent, where our businesses do not currently operate?
With a lens on the future, if we reimagine possibilities that a virtual world brings, suddenly a virtual office, not filled with avatars, but holograms can feel like a not-so-distant reality.
Undoubtedly, the workplace is being redefined and reimagined, built upon new thinking around productivity and engagement, and the opportunity that technology brings.
More connected yet less connection
Advances in technology and design architecture are radicalising the concept on the workspace, at the heart of which will be a focus for active, creative, productive work participation, not constrained by physical boundaries or outdated mindsets. Work is becoming a thing that you do, not a place that you go.
Yet as technology brings opportunity, the remote environment that that the digital world unearths, poses an interesting challenge. Social media and the internet connect us to hundreds and thousands of people, yet research by the Office for National Statistics, showed that 5% of adults (16 and over) in England reported feeling lonely "often / always" – that's 1 in 20 adults. Interestingly, the younger adults reported that they experience loneliness more often. We see today how young people can have thousands of friends online, and yet perpetually feel unsupported and isolated.
(Source: "Loneliness – what characteristics and circumstances are associated with feeling lonely?", ONS 2018)
This insight leads us to question whether we are really understanding what impact the advancement of technology is having on the future of relationships? From birth to death, human beings are hard-wired to connect to other human beings. In her book, "The Village Effect" psychologist Susan Pinker explores how face-to-face contact is crucial for learning, happiness, resilience and longevity, as she brings together the findings of the new field of social neuroscience with gripping human stories. Most of us have left the literal village behind, and don't want to give up our new technologies to go back there. There is evidence however, that supports the notion that we need close social bonds and uninterrupted face-time with our friends, families and co-workers in order to thrive―even to survive.
As technology allows us to become more remote, do we need to rethink connection?
Connection is more powerful than you think. It is more than how may bars of reception you have or how strong the Wi-Fi is. A strong network is less about the number of LinkedIn connections you have, or how many likes you get on your Instagram feed.
It is about turning the conversations, the meetings and the interactions with others, into something purposeful, and meaningful. As we mindlessly allow social media and online interactions to define our ways of engaging, do we need to re-frame the how we connect with others?
Connectivity has the power to supercharge and transform the relationships we have, nurture and build, but equally the possibility to erode them. We have the tools and technology at our fingertips to collaborate, share and engage, but how we use the technology is key. Can we better leverage technology to keep hold of the face-to-face contact that is so important to us as humans? How do we replicate a true sense of community in an increasingly disparate world? In a world where people and technology collide in new ways, our challenge today is to consciously create our new village in a digital world.
Article tags...
Connectivity,Flexible working,Future of work,Remote working,Workplace transformation
Hema Bakhshi
Read more & connect
Surviving digital disruption through better collaboration
By Steven Willert
Getting the most from your remote team
By Jenny Barnes
Social as a destination (having to go to a place to get stuff done)
By Jonathan George
Tips for online meeting etiquette
By Adé Benjamin
How your company can reduce its carbon footprint
Contact us for more information around our technology adoption services.
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redpajama_set_name: RedPajamaCommonCrawl


text:
Paolo Giordano (1962-2021), musicien italien
 Paolo Giordano (né en 1982), écrivain italien

redpajama_set_name: RedPajamaWikipedia


is a splendid, 16th-century villa. The property of one of Florence?s oldest families and respected wine makers, it stands on a hill overlooking the Chianti vineyards. Interestingly, the site of ?Castello Pinsent? originally housed an 11th century observation tower. In the 16th century this was enlarged and adapted to be restored and completed in the 19th century.
?Castello Pinsent? commands breathtaking views over rolling vineyards and the Duomo of Florence. The picturesque, two-acre garden was designed in the 1930s by the famous English architect, Cecil Pinsent. The garden leads up to front terrace of the house and makes the perfect spot for reading, relaxing and al fresco dining. The pool is positioned on one side of the garden overlooking the property?s vineyards as they extend towards the Duomo of Florence and Giotto's bell-tower.
Newly restored and refurbished by its owners, ?Castello Pinsent? has charming interiors, is beautifully decorated with trompe l?oeil effects, not to mention superb antique furniture.
For smaller groups, please see Villa Pinsent, which sleeps 12, and groups of 14 guests can benefit of a discount on the published rental prices.
Ground Floor: From a large entrance hall, to the right a dining room leads to a large fully-equipped kitchen. A sitting room with a service bathroom leads to the front terrace. To the left of the entrance is a second living room with parquet floor, fireplace and television. Further on a decorated sitting room leads into a large decorated dining room with fireplace and a painted terracotta floor.
First Floor: A two-ramp stairway leads up to a large closet and corridor. To the right there is a twin bedroom and a double bedroom sharing a bathroom with shower. To the left is a spacious double bedroom with sitting room and fireplace and its en suite bathroom with tub.
Second Floor: Up the stairway to the right is a double bedroom with en suite bathroom with bath. Two twin bedrooms share a bathroom with shower. A sitting room serves these bedrooms. To the back of the stairway there is a large double bedroom with its en suite and very spacious bathroom with both shower and tub.
The tower: On two different levels are located one twin bedroom with its en suite bathroom with tub and a double bedroom with an en suite bathroom with shower.


just a brief message to let you know that I'm back home. I was discharged yesterday afternoon but there was so much to do once back here that Anna didn't have time to update.
I'm greatly improving, both morale-wise and physically, as a result of getting out of hospital, which I found a nightmare despite the caring staff etc. Once I feel sufficiently rested, I will do a post about it though it will probably only be of interest to fellow-sufferers who may have to go through the same process one day. It will certainly not be for the faint-hearted as I will be trying to describe and account for some of the worst feelings I've ever experienced in-between a few brighter spots.
I can hardly start to tell you how happy your brief message has me, and I assume safely, all your readers! Please concentrate on getting better – all the rest is secondary!
Rest, rest, rest and think about all you will do, write and enjoy in the months and years ahead …including sharing hospital horrors!
A little free time this morning has allowed me to browse recent entries in your blog.
I hesitated long and hard before answering on the blog instead of the more private email.
What if I say the wrong thing ? What will people think ?
Well, hello, friends of Bart, if you happen to read this.
I checked out the entries about your operation, the wedding and the honeymoon. I skipped the bit about British politics (as you might expect..).
I am struck by what a full and rewarding life you have. Many friends, a beautiful and loving wife and a charming young daughter. Writing projects… I swear to God, if you don't pull through with this thing, I will howl and throw stones !
My feeling is that you will pull through.
Reading about your friends and relations, I am reminded of the times spent in St Girons and the people I met at your place – always interesting and delightful. You seem to have a knack for attracting interesting people of different backgrounds and maintaining friendships over time.
The fact that you have the energy and courage to write your blog, take beautiful photos, get married, keep up your relationships, keep on writing, this is all a very good and healthy sign !
I hope you are feeling better, gradually improving.
All my respects and encouragement to your wife and family.
I look forward to seeing you back here and sharing an evening's conversation over a glass of wine (or tea if you prefer).


Lent and Easter is a unique time to visit Gozo because it allows you to witness the faith and devotion of the local communities and to experience deep-rooted religious traditions. In the run up to Easter, this small island hosts a range of religious events; from religious processions, street-based Passion productions through to more personal pilgrimages.
Each year during Lent church authorities organise a 'Pilgrimage of Penance' on Ta' Għammar Hill, which is opposite Ta' Pinu sanctuary – a route known as Via Crucis or The Way of the Cross. If you've never walked this path for yourself, then Ta' Għammar hill is an emotive and dramatic pilgrims' way (good walking shoes and a bottle of water are also essential).
According to local folklore, the route originated because of Frangisk Portelli from Għarb, a devout man, who in the late 1800's claimed he'd heard a voice coming from the holy picture of the Virgin Lady of Ta Pinu asking him to start a special devotion through pilgrimage. By the end of World War II, devotees began making personal pilgrimages up the hilltop as an act of repentance. Eventually, this path was established as a Via Crucis for pilgrims.
As travellers make their way from Ta Pinu Sanctuary and climb the winding path to the top of Ta' Għammar Hill they encounter 14 white marble statues depicting the final hours in the life of Jesus Christ. These statues were installed along the route in the early 1980's and are based on the designs of the late great Gozitan sculptor, Alfred Camilleri Cauchi.
The 'Pilgrimage of Penance' happens at dusk with candles and torch lights to illuminate the participants' path, adding an extra poignancy to this sacred journey. This year's event begins at 4.30 pm on Sunday 7th April and is led by H.E. Monsignor Mario Grech, the Bishop of Gozo.
Around Holy Week, Gozo's streets come alive with religious dramatisations and sacred processions. An important event held during Lent is the passion re-enactment L-Imsallab fi Triqatna produced by Għaqda Dilettanti Ġimgħa l-Kbira – Għawdex.
Jesus and Barrabas paraded before the people by Għaqda Dilettanti Ġimgħa l-Kbira – Għawdex. Photo Credit: Martin Attard.
This year's passion play takes place on Saturday 6th April, 2019 at 7.00pm from St Augustine's Square, Victoria, Gozo.
It was almost 300 years ago when Pope Benedict XIII declared that Our Lady of Sorrows feast must be honoured by the Church worldwide; nowadays this religious event is a long-served tradition in Gozo. These processions traditionally happen the Friday before "Good Friday".
Għaqda Drammatika Għajnsielem are a theatre group from Għajnsielem who for over 30 years have been producing biblical re-enactments centred around Holy Week.
Ta' Passi fields, Għajnsielem, Photo credit: Joseph Sultana.
Many of their 'live' performances take place at Ta' Passi fields in Għajnsielem, where their live Bethlehem village is staged every December. However, during Lent, Ta' Passi fields will host a modern Way of the Cross, a live Passion production as well as a live re-enactment of The Last Supper.
Their Our Lady of Sorrows procession with actors performing scenes from around the time of Jesus's death leaves Għajnsielem Parish church at 6.30pm on 12th April 2019 and passes through the main streets of Għajnsielem.
Our Lady of Sorrows Drama by Għaqda Drammatika Għajnsielem. Photo credit: Joseph Sultana.
Good Friday processions started on the Maltese islands around the 16th century with Spanish and Sicilian influence. Victoria, Nadur, Xagħra, Xewkija, Qala, Ghasri and Żebbuġ commemorate the Passion of Christ with a very solemn procession of statues. Each of these statues represents a particular episode in the Passion of the Christ which is carried by pallbearers. In some of these events chained and masked or cross-bearing 'penitents' take part.
This particular aspect of the ceremony (which can sometimes look rather ominous to a newcomer) actually dates back to the 18th century and to Malta's oldest city of Birgu, when slaves and forzati (subjects condemned for various reasons to wear chains) took part in this event.
Easter Sunday is the climax of the Holy Week events – celebrating the Resurrection of Jesus Christ. The peal of church bells ring out throughout Gozo welcoming Christians into their churches for the Easter Mass services. Some parishes follow this service with a traditional march parading the statue of our risen Christ, which is usually accompanied by local bands.


text:
<?php

declare(strict_types=1);

namespace Cappuccino\TokenParser;

use Cappuccino\Error\SyntaxError;
use Cappuccino\Node\BlockNode;
use Cappuccino\Node\BlockReferenceNode;
use Cappuccino\Node\Node;
use Cappuccino\Node\PrintNode;
use Cappuccino\Token;
use function sprintf;

/**
 * Class BlockTokenParser
 *
 * {% block toolbar %}
 *     This section of the template is reusable.
 * {% endblock %}
 *
 * @author Bas Milius <bas@ideemedia.nl>
 * @package Cappuccino\TokenParser
 * @since 1.0.0
 */
final class BlockTokenParser extends AbstractTokenParser
{

	/**
	 * {@inheritdoc}
	 * @author Bas Milius <bas@mili.us>
	 * @since 1.0.0
	 */
	public function parse(Token $token): Node
	{
		$lineno = $token->getLine();
		$stream = $this->parser->getStream();
		$name = $stream->expect(Token::NAME_TYPE)->getValue();

		if ($this->parser->hasBlock($name))
			throw new SyntaxError(sprintf("The block '%s' has already been defined line %d.", $name, $this->parser->getBlock($name)->getTemplateLine()), $stream->getCurrent()->getLine(), $stream->getSourceContext());

		$this->parser->setBlock($name, $block = new BlockNode($name, new Node([]), $lineno));
		$this->parser->pushLocalScope();
		$this->parser->pushBlockStack($name);

		if ($stream->nextIf(Token::BLOCK_END_TYPE))
		{
			$body = $this->parser->subparse([$this, 'decideBlockEnd'], true);

			if ($token = $stream->nextIf(Token::NAME_TYPE))
			{
				$value = $token->getValue();

				if ($value != $name)
					throw new SyntaxError(sprintf('Expected endblock for block "%s" (but "%s" given).', $name, $value), $stream->getCurrent()->getLine(), $stream->getSourceContext());
			}
		}
		else
		{
			$body = new Node([
				new PrintNode($this->parser->getExpressionParser()->parseExpression(), $lineno),
			]);
		}

		$stream->expect(Token::BLOCK_END_TYPE);

		$block->setNode('body', $body);
		$this->parser->popBlockStack();
		$this->parser->popLocalScope();

		return new BlockReferenceNode($name, $lineno, $this->getTag());
	}

	/**
	 * Returns TRUE if the block should end.
	 *
	 * @param Token $token
	 *
	 * @return bool
	 * @author Bas Milius <bas@ideemedia.nl>
	 * @since 1.0.0
	 */
	public function decideBlockEnd(Token $token): bool
	{
		return $token->test('endblock');
	}

	/**
	 * {@inheritdoc}
	 * @author Bas Milius <bas@mili.us>
	 * @since 1.0.0
	 */
	public function getTag(): string
	{
		return 'block';
	}

}

redpajama_set_name: RedPajamaGithub


text:
18 This study investigated Taiwanese physicians' and nurses'
18 This study investigated Taiwanese physicians' and nurses' GSK-3 inhibitor knowledge of malaria, yellow fever, and dengue fever. The results can help government and medical care systems promote the professional development of travel medicine and enhance the quality of travelers' health care. This study represents a cross-sectional questionnaire survey of physicians and nurses interested in travel medicine. The Training Center for Travel Medicine from the National Taiwan University held three nationwide one day seminars on travel medicine in the northern, southern, and eastern part of Taiwan from April to September of 2008.
The seminars were promoted in hospitals interested in travel medicine nationwide and advertized on internet websites. These seminars were also supported by the Center for Disease Control of Taiwan and the Taiwan Association of International Health. Participants were mainly hospital-based physicians and nurses. The questionnaire and consent forms were administered to all participants prior to the seminars and were returned CX-5461 purchase before
the start of the seminars. All the study procedures were approved by the Ethical Committee of the National Taiwan University Hospital. The self-administered, single-choice questionnaire included four parts and started with an assessment of general background information. The remaining three parts included 17 questions regarding knowledge of the epidemiology, preventative medications for malaria (6 questions), yellow fever (4 questions), dengue fever (5 questions), and vaccine information for yellow fever (2 questions). The questionnaire was based upon personal practice experiences and designed after a careful literature review. Five experts tested the content
validity, while the face validity was tested by two physicians and three nurses. The scores from the knowledge of each disease were summed by assigning each correct answer one point. Data management and statistical analyses were performed using SPSS 11.0 software. Baricitinib Frequency distributions described the demographic data. The chi-square test was used to compare the percentage of correct answers between physicians and nurses for each question, and the t-test was used to compare the overall scores between the two groups. A p value less than 0.05 was considered statistically significant. A total of 289 health-care providers (86 physicians and 203 nurses) who were interested in travel medicine were given the questionnaire, and all responded. After eliminating four incomplete questionnaires, 285 were included in the final analysis (85 physicians and 200 nurses). The mean age was 37.4, and no health-care provider had received any prior certification in travel medicine.
In classical cases, this prodrome may be followed by skin rash, b
In classical cases, this prodrome may be followed by skin rash, bite-eschar(s), regional
lymphadenopathy, conjunctival injection, icteric sclera, jaundice, and bradycardia. 25,27 Later, patients may develop potentially fatal complications including adult respiratory distress syndrome (ARDS), especially in older patients, hypotensive shock, acute renal failure, encephalomyelitis, and disseminated intravascular coagulation (DIC). 25 Frequently, patients presenting with similar constellations of constitutional symptoms and few pathognomonic signs (eschar, rash, and hearing loss) in rural scrub typhus-hyperendemic areas are often treated preemptively and empirically with oral doxycycline. 26 click here Rural regions may have limited access to specific serological tests (immunofluorescent antibody assays and paired sera comparisons for rising specific antibody titers) required to differentiate scrub typhus from other endemic rickettsial diseases. 25,26 Weekly doses of 200 mg
of doxycycline can prevent O tsutsugamushi infections. 25 The house-mouse mite, L sanguineus, maintains a rickettsial zoonosis in its preferred MDV3100 house-mouse (Mus musculus) reservoir, and can transmit rickettsialpox caused by R akari through bites. 1,27,28 Although initially described in clusters in crowded apartment buildings in large US cities, including New York, Boston, Cleveland, Philadelphia, and Pittsburgh, rickettsialpox has now been reported in rural areas of the United States and Eurasia. 27,28 Many experts now feel that rickettsialpox is underreported
and distributed in silent sylvan cycles worldwide. 27,28 The incubation period and initial clinical manifestations of rickettsialpox mirror those of scrub typhus with bite-eschar formation within 10 to 12 days, followed by fever, chills, severe headache, conjunctival injection, and truncal maculopapular, then vesicular, rash. 27,28 Unlike scrub typhus, complications are rare, but may include thrombocytopenia and interstitial pneumonia. 27,28 Hearing loss does not occur, and regional lymphadenopathy Carbohydrate is uncommon in rickettsialpox. The clinical manifestations, diagnosis, and management of scrub typhus and rickettsialpox are contrasted in Table 3. In summary, mites are mostly ubiquitous, bothersome pests, with few species of medical importance and, of these, most are scabies mites, trombiculid larvae, and rodent mites. All patients with scabies and their close household, institutional, and sexual contacts should be informed that scabies is a highly transmissible ectoparasitic infestation and that several topical treatments and an effective oral treatment are readily available and highly effective at present. Finally, only the Asian and Eurasian Leptotrombidium species of trombiculid larvae (chiggers) can transmit scrub typhus in endemic regions of Asia, Eurasia, and the South and West Pacific; and only the house-mouse mite can transmit rickettsialpox in both urban and rural dwellings worldwide. Support for Prof.
, 1991) We then tested whether the reductions in GluA1 and GluA4
, 1991). We then tested whether the reductions in GluA1 and GluA4 in the molecular layer were due to their reduced expression in Bergmann glia. To this end, we employed double immunofluorescence for the glutamate transporter GLAST, an astrocyte-specific molecule particularly enriched in Bergmann glia (Shibata et al., 1997; Yamada et al., 2000), and we omitted pepsin pretreatment to preferentially detect nonsynaptic AMPA receptors (Fukaya et al., 2006). Immunofluorescent signals for GluA1 or GluA4 overlapped well with GLAST
in the molecular layer of WT AZD2281 and γ-7-KO mice, and the intensities were substantially reduced in the latter mice as compared to the former (Fig. 8). These results suggest that the ablation of γ-7 reduces expression of AMPA receptors in Bergmann glia. Finally, we examined functional reductions in AMPA receptors by electrophysiology. Whole-cell patch-clamp recording was conducted from Purkinje cells in acute slices prepared from WT and respective KO mice. First, we examined the climbing fiber-mediated excitatory postsynaptic current (EPSC) that is solely mediated by AMPA receptors (Konnerth et al., 1990; Kano et al., 1995). In γ-7-KO mice, climbing fiber EPSCs were
normal (Fig. 9A and B). On the other hand, the peak amplitude Wee1 inhibitor of climbing fiber EPSCs decreased progressively, in the order WT = γ-7-KO > γ-2-KO > DKO (Fig. 9A and B). Next, we measured membrane currents in Purkinje cells induced by bath-applied AMPA (Fig. 9C). The current recorded in the standard external solution during voltage ramp (holding potential of +40 to −60 mV, 1.7 s) was subtracted from the current recorded in the presence of 5 μm AMPA. The acetylcholine AMPA receptor-mediated currents also decreased in the order WT > γ-2-KO > DKO (Fig. 9C). Because parallel fiber synapses (105–106 per Purkinje cell) far outnumber climbing fiber synapses (presumably by a factor of several hundred; Napper & Harvey, 1988; Kurihara et al., 1997), the reduced AMPA-induced currents in Purkinje cells are considered to virtually reflect functional loss of AMPA receptors at parallel
fiber–Purkinje cell synapses. These electrophysiological data are consistent with the anatomical data and suggest that γ-2 and γ-7 cooperatively promote synaptic expression of AMPA receptors at climbing fiber and parallel fiber synapses in Purkinje cells, while the ablation of γ-7 by itself causes no apparent changes. Of the six TARP members (Chen et al., 2000; Tomita et al., 2003; Kato et al., 2008) we focused on γ-2 and γ-7, the highest expression levels of which are in two major cerebellar neuron types, i.e., granule cells and Purkinje cells (Fukaya et al., 2005). In the present study, we produced specific antibodies against γ-2 and γ-7 to determine their synaptic localization in the cerebellum, and also produced mutant mice lacking these TARPs to pursue their role in synaptic expression of cerebellar AMPA receptors.
in the molecular layer of WT Ruxolitinib clinical trial and γ-7-KO mice, and the intensities were substantially reduced in the latter mice as compared to the former (Fig. 8). These results suggest that the ablation of γ-7 reduces expression of AMPA receptors in Bergmann glia. Finally, we examined functional reductions in AMPA receptors by electrophysiology. Whole-cell patch-clamp recording was conducted from Purkinje cells in acute slices prepared from WT and respective KO mice. First, we examined the climbing fiber-mediated excitatory postsynaptic current (EPSC) that is solely mediated by AMPA receptors (Konnerth et al., 1990; Kano et al., 1995). In γ-7-KO mice, climbing fiber EPSCs were
normal (Fig. 9A and B). On the other hand, the peak amplitude Selleckchem Doramapimod of climbing fiber EPSCs decreased progressively, in the order WT = γ-7-KO > γ-2-KO > DKO (Fig. 9A and B). Next, we measured membrane currents in Purkinje cells induced by bath-applied AMPA (Fig. 9C). The current recorded in the standard external solution during voltage ramp (holding potential of +40 to −60 mV, 1.7 s) was subtracted from the current recorded in the presence of 5 μm AMPA. The Benzatropine AMPA receptor-mediated currents also decreased in the order WT > γ-2-KO > DKO (Fig. 9C). Because parallel fiber synapses (105–106 per Purkinje cell) far outnumber climbing fiber synapses (presumably by a factor of several hundred; Napper & Harvey, 1988; Kurihara et al., 1997), the reduced AMPA-induced currents in Purkinje cells are considered to virtually reflect functional loss of AMPA receptors at parallel
in the molecular layer of WT selleck and γ-7-KO mice, and the intensities were substantially reduced in the latter mice as compared to the former (Fig. 8). These results suggest that the ablation of γ-7 reduces expression of AMPA receptors in Bergmann glia. Finally, we examined functional reductions in AMPA receptors by electrophysiology. Whole-cell patch-clamp recording was conducted from Purkinje cells in acute slices prepared from WT and respective KO mice. First, we examined the climbing fiber-mediated excitatory postsynaptic current (EPSC) that is solely mediated by AMPA receptors (Konnerth et al., 1990; Kano et al., 1995). In γ-7-KO mice, climbing fiber EPSCs were
normal (Fig. 9A and B). On the other hand, the peak amplitude Ponatinib research buy of climbing fiber EPSCs decreased progressively, in the order WT = γ-7-KO > γ-2-KO > DKO (Fig. 9A and B). Next, we measured membrane currents in Purkinje cells induced by bath-applied AMPA (Fig. 9C). The current recorded in the standard external solution during voltage ramp (holding potential of +40 to −60 mV, 1.7 s) was subtracted from the current recorded in the presence of 5 μm AMPA. The Bacterial neuraminidase AMPA receptor-mediated currents also decreased in the order WT > γ-2-KO > DKO (Fig. 9C). Because parallel fiber synapses (105–106 per Purkinje cell) far outnumber climbing fiber synapses (presumably by a factor of several hundred; Napper & Harvey, 1988; Kurihara et al., 1997), the reduced AMPA-induced currents in Purkinje cells are considered to virtually reflect functional loss of AMPA receptors at parallel
45-μm filter Ten microlitres of culture supernatant or SDS extra
45-μm filter. Ten microlitres of culture supernatant or SDS extract was added to 100 μL of the fish serum. Subsequently, the mixture was incubated at 37 °C for 24 h. Serum opacification was determined
on the basis of OD measured using a microplate reader at 405 nm. When the OD value exceeded 0.1 compared with control (TH broth with serum, 0.5% SDS with serum), opacification activity was considered to be positive. Horse, pig, cow (GIBCO/Invitrogen, USA) and human sera (TaKaRa Bio, Inc., Japan) were also used for opacification tests with culture supernatant of fish isolate 12-06 as described above. To visualize opacification activity, 5 μL of cell cultures adjusted to an OD660 of 1.0 from strain 12-06 was dropped onto TH agar containing 10% of fish, horse, pig, cow or human sera, then incubated at 37 °C for 24 h. All used sera were heat-inactivated see more at 55 °C for 30 min. PD0325901 clinical trial Genomic DNA from the representative fish isolate 12-06 was used in this study (Nomoto et al., 2004, 2006; Nishiki et al., 2010). DNA techniques were performed as described previously (Nishiki et al., 2010). Table 1 lists the primers used in this study. PCR amplification of the sof-FD gene was performed using degenerate primers SOF-d1 and SOF-d2, which were designed on the basis of several sof genes and fnbA (accession number Z22150). The PCR products
amplified with SOF-d1 and SOF-d2 were then extended by 5′- and 3′-rapid amplification of cDNA ends (RACE) PCR with the primer sets RACE SOF-fd1 and RACE SOF-fd2. The RACE-PCR was performed using the SMART RACE cDNA amplification kit according to the manufacture's protocol (TaKaRa Bio). The entire sof-FD gene was amplified,
and subsequently TA-cloning and sequencing were performed as described previously (Nomoto et al., 2008). The amino acid sequence of sof-FD was analysed using bioedit version 7.0 (Hall, 1999) with the reference sequences of other SOFs obtained from GenBank. The signal peptide and structural domains were predicted using the signalp program (http://www.cbs.dtu.dk/services/SignalP/) and the simple modular architecture research tool (smart) version 4.0 (http://www.smart.enblheidelbergde/). To construct a recombinant plasmid, primer sets SOF-OFD1 and SOF-OFD2 were designed to contain an opacification domain referring to SOF2 (AAC32596) Amino acid obtained from S. pyogenes (Courtney et al., 1999). The amplified product was then ligated into the pBAD TOPO vector system (Invitrogen Japan K. K., Japan) and transformed into Escherichia coli TOP10 following the manufacturer's protocols. The recombinant protein, amino acid residues 115–780 of sof-FD is referred to as rSOF-OFD. Expression of His-tagged rSOF-OFD was induced following the manufacturer's protocol. The lysates of the recombinant E. coli TOP10 were purified by His Trap affinity columns (GE Healthcare) according to the user's manual.
Percentage viability was calculated as the number of viable cells
Percentage viability was calculated as the number of viable cells after treatment divided by the total number of cells without peptide, times 100. Overnight cultures in THYE were pelleted, washed, resuspended in sterile 1× PBS, and diluted 1 : 100 using warm
CDM. Each suspension was supplemented with either 1% DMSO or 10 μM XIP and used to inoculate polystyrene plates. After 24-h incubation, the biofilms were dried and strained with 0.1% Safranin Red. Overnight cultures of UA159 Selleck SB431542 and its derivatives were diluted 20× in fresh THYE or CDM and grown to an OD600 of 0.4–0.5 in the presence or absence of 0.4 μM CSP or 10 μM XIP, respectively. For growth in CDM, overnight cells were washed and resuspended in 1× PBS prior to inoculation and harvesting. Controls included THYE without added peptide, as well as CDM with 1% DMSO. RNA isolation, DNAse treatment, cDNA synthesis, qRT-PCR, and expression analyses were carried out as previously described (Senadheera et al., 2005). Primers used for qRT-PCR are as follows: comR (For: CGTTTAGGAGTGACGCTTGG, Rev: TGTTGGTCGCCATAGGTTG), comS (For: TTTTGATGGGTCTTGACTGG, Rev: TTTATTACTGTGCCGTGTTAGC) and comX (For: ACTGTTTGTCAAGTCGCGG Rev: TGCTCTCCTGCTACCAAGCG). Expression was normalized to that of 16SrRNA gene, and statistical analyses were performed on four independent experiments using Student's Selleckchem Saracatinib t-test (P < 0.05). Overnight cultures in CDM were
diluted 100-fold and grown for 48 h at 37 °C in 5% CO2 air mixture. Cell-free supernatants were obtained by centrifugation and filter sterilized using a 0.45-μm syringe filter. Samples were lyophilized and,
once dry, reconstituted in 2 mL of 5% MeOH/H2O (v/v) prior to analysis by HPLC-ESI-MS/MS (Dionex UltiMate 3000 HPLC system with variable UV detection in line to a Bruker amaZon X ion-trap mass spectrometer operating in positive ionization mode with auto MS/MS enabled). Analytical scale analysis was performed on a 250 × 4.60 mm Phenomenex Luna 5μ C18(2) 100 Å column (Serial no. 516161-20) with a flow rate of 1 mL min−1 and the following program consisting of solvents A (water + 0.1% formic Nintedanib (BIBF 1120) acid) and B (acetonitrile + 0.1% formic acid): 0–2 min, equilibration at 5% B; 2–18 min, linear gradient to 100% B; 18–20 min, constant 100% B, 20–20.5 min, linear decrease to 5% B; 20.5–23 min re-equilibration at 5% B. The identity of XIP in culture supernatants was confirmed by comparison with the retention time and MS/MS fragmentation of sXIP. To quantify XIP levels, a directed LC-MS/MS experiment was performed using selected-reaction monitoring (SRM) MS/MS. The SRM m/z transition 876.4 658.4 was monitored, corresponding to a –SL loss from the GLDWWSL parent ion, generating a GLDWW daughter ion. Resulting peak areas were integrated, and final concentrations calculated from a linear calibration curve created using CDM spiked with sXIP and processed in an identical way to cell free supernatants.
(1988) In addition, determination of yeast cultivation factors t
(1988). In addition, determination of yeast cultivation factors that can influence cell resistance to dehydration with concomitant reversible suspension of yeast metabolism has been reported previously.
For example, yeast cultivation in rich nutrient media has been shown to lead to the formation of more resistant Selleckchem PLX4032 yeast populations compared with cells grown in poor synthetic nutrient media (Beker & Rapoport, 1987). Additionally, stationary-phase cells of bakers' yeast, S. cerevisiae, are rather resistant to dehydration–rehydration, whereas the viability of exponential-phase cells following dehydration is severely compromised (Beker & Rapoport, 1987). It has been established that key metal ions, such as magnesium and calcium, play important roles in yeast physiology and biotechnology (Walker, 1994, 1999, 2004). Magnesium bioavailability dramatically influences yeast growth and metabolism in a beneficial manner, but calcium ions can antagonize essential magnesium-dependent functions in yeast (Walker, 1999). Sufficiency of intracellular free magnesium ions is absolutely required for the function of key enzymes and for Veliparib cell membrane stabilization. Regarding the latter, magnesium acts in the physiological stress protection of yeast cells, by preventing increases in cell
membrane permeability caused by ethanol- and temperature-induced stress (Birch & Walker, 2000). The aim of the present investigation was to determine whether magnesium and calcium ions influenced the resistance of yeast cells to dehydration–rehydration. Lck Cultures of the yeast S. cerevisiae strain 14 used in this work were received from the collection of the Laboratory of Cell Biology, Institute of Microbiology and Biotechnology, University of Latvia. Cultures were grown on nutrient media containing (g L−1): molasses, 20; (NH4)2SO4, 3.7; MgSO4, 0.75; NaCl, 0.5; KH2PO4, 1.0;
K2HPO4, 0.13, pH 5.0; in flasks with total volume 250 mL in an orbital shaker (140 r.p.m.) at 30 °C. In some experiments, the nutrient medium did not contain MgSO4 or contained its higher concentration – 1.5 g L−1. In Ca2+-supplementation experiments, calcium salts were added to the medium in concentrations of 2.0 or 5.0 g L−1. Biomass yield was determined by its drying to a constant weight at 105 °C. Biomass dehydration was performed using a convective method in an oven at 30 °C for 24 h. The residual moisture reached in these conditions was 8–10%, determined by drying to a constant weight at 105 °C. At such residual moisture (if adequately dehydrated), yeast can maintain its viability due to being in a state of anhydrobiosis. The survival rates of dehydrated cultures were determined using fluorescence microscopy with the fluorochrome primulin. We have previously shown that, using certain conditions for yeast dehydration, this viability test corresponds very well to traditional tests based on agar plate counts (Rapoport & Meysel, 1985).
In conclusion, our results show that MAC infections prior to HAAR
In conclusion, our results show that MAC infections prior to HAART initiation impair subsequent immune reconstitution, confirming and extending previous data from another group [9]. These patients must therefore be considered for more aggressive and powerful initial HAART regimens. "
"NT-26 is a chemolithoautotrophic 17-AAG arsenite oxidizer. Understanding the mechanisms of arsenite signalling, tolerance and oxidation by NT-26 will have significant implications
for its use in bioremediation and arsenite sensing. We have identified the histidine kinase (AroS) and the cognate response regulator (AroR) involved in the arsenite-dependent transcriptional regulation of the arsenite oxidase aroBA operon. AroS contains a single periplasmic sensory domain that is linked through transmembrane helices to the HAMP domain that transmits the signal to the kinase core of the protein. AroR belongs to a family of AAA+ transcription regulators that interact with DNA through a helix-turn-helix domain. The presence of the AAA+ Cisplatin molecular weight domain as well as the RNA polymerase σ54-interaction sequence motif suggests that this protein regulates transcription
through interaction with RNA polymerase in a σ54-dependent fashion. The kinase core of AroS and the receiver domain of AroR were heterologously expressed and purified and their autophosphorylation and transphosphorylation activities were confirmed. Using PDK4 site-directed mutagenesis, we have identified the phosphorylation sites on both proteins. Mutational analysis in NT-26 confirmed that both proteins are essential for arsenite oxidation and the AroS mutant affected growth with arsenite, also implicating it in the regulation of arsenite tolerance. Lastly, arsenite sensing does not appear to involve thiol chemistry. Arsenic is a naturally occurring toxic metalloid whose soluble forms, arsenite (H3AsO3) and
arsenate (HAsO42−/H2AsO4−), can be used by certain prokaryotes for respiration (Stolz et al., 2006). Arsenite is most abundant in anoxic environments because, in oxic environments, it becomes readily oxidized to arsenate by arsenite-oxidizing bacteria –'arsenite oxidizers' (Stolz et al., 2006). Depending on their obligate source of carbon, arsenite oxidizers are either autotrophic or heterotrophic organisms that utilize either oxygen or nitrate as the terminal electron acceptor (Stolz et al., 2006). Rhizobium sp. str. NT-26 is a facultative chemolithoautotrophic arsenite oxidizer that was isolated from the Granites goldmine, Northern Territory, Australia (Santini et al., 2000). It oxidizes arsenite using a periplasmic heterotetrameric arsenite oxidase (Aro), which is part of an electron transport chain involving a soluble c-type cytochrome and cytochrome oxidase (Santini & vanden Hoven, 2004; Santini et al., 2007).
(A) CQ212 When is hysteroscopy
(A) CQ212 When is hysteroscopy DAPT indicated? Answer 1 Diagnosis for conditions as stated below. (C) Endometrial polyps Submucosal fibroids Uterine anomalies Intrauterine adhesions (Asherman's syndrome) Endometrial hyperplasia Endometrial cancer Spontaneous abortion or residues after expulsion of hydatidiform mole Residual placenta, placental polyp Intrauterine object (IUD) Endometrial polyps Submucosal fibroids Septate uterus Intrauterine adhesions (Asherman's syndrome) CQ213 How do we treat endometriosis without cystic lesions? Answer 1 Prescribe analgesics (non-steroidal anti-inflammatory drugs [NSAIDs]) for pain. (B) CQ214 What are the differential diagnoses
and management of suspected benign ovarian cysts? Answer 1 To differentiate between malignant tumors, non-tumor lesions and functional cysts, history-taking, vaginal examination, ultrasonography, tumor marker tests, MRI etc. should be performed. (B) CQ215 How do we diagnose hemorrhaging corpus luteal cyst or ovarian hemorrhage? Answer 1 Perform a general evaluation by history-taking, basal body temperature measurement, abdominal examination, ultrasonography. (B) CQ216 How do we treat ovarian endometrial cyst
(chocolate cyst)? Answer 1 The choice of treatment, GSK2118436 datasheet which includes observation, medication or surgery, is made based on the patient's age, size of the cyst(s), and the patient's desire to conceive. Surgery is usually prioritized due to fear of rupture, infection or malignant transformation of the cyst. (B) CQ217 How do we diagnose and treat adenomyosis? Answer 1 Clinical findings, internal examination, and ultrasonography can provide the appropriate diagnosis. However, for differential diagnosis against uterine fibroids or uterine sarcomas, MRI should be undertaken. (B) CQ218 When do we perform operative hysteroscopy/transcervical resection (TCR) for submucosal fibroids? Answer
1 The usual criteria for the procedure are small uterine fibroids (less than 30 mm in size) and more than 50% protrusion in the uterine cavity. However, skilled CHIR-99021 surgeons may not be constrained by these criteria. (B) CQ219 What are the considerations for a patient with intramural and/or subserosal uterine fibroids who wishes to opt for conservative therapy? Answer The type of treatment should be chosen based on the location and size of the fibroids, whether or not the patient has menorrhagia or anemia, age of the patient and the patient's prospects in conceiving. (A) CQ220 How do we manage patients with cervical polyps? Answer 1 The polyp should be resected for pathological evaluation. (B) CQ221 How do we manage Bartholin's cysts? Answer 1 Asymptomatic cases with minimal swelling do not require treatment.


Because one A-Rod tainted championship (2009) is enough for me... I don't need FOUR.
but I'll allow it... outta' respect.
(BTW, All FIVE of the Patriots SB Trophies were "legit".) Envy green looks good on you . . .
Last edited by KenFougere; 08-22-2017, 12:48 AM.
This statement means that you a.) Don't subscribe to ESPN: The Magazine, b.) have lost all objectivity on the matter, or c.) have gone completely insane.
Have you been drinking? Drugs? Touch of Dementia maybe?
*But seriously, I'm rooting SO hard for the Cubbies too!
Finally, we're in it again!
BOSTON (AP) — For all the money the Red Sox are paying David Price, the Boston fans don't just want a pitcher who gives the team a chance to win every five days. And it's not enough for him to wind up among the Cy Young contenders in the offseason.
With a seven-year, $217 million contract that is the richest ever for a pitcher, the Red Sox are expecting playoff wins.
And that's the one thing Price hasn't delivered.
"I think I was just saving all my postseason wins for the Red Sox," Price said on Friday during his introductory news conference in a Fenway Park function room filled with championship memorabilia.
"I know good things are going to happen to me in October. That just hasn't been the case thus far," said Price, who is 0-7 with a 5.27 career ERA in eight career postseason starts. "I know I can throw the ball as well in October as I do in the regular season. That time is coming for me, and hopefully it's in 2016."
Off-site Poll Link . . .
Who will win the American League East Division in 2016?
will start "Bitter Rivals Thread's"
Sean McAdam of CSNNE.com reported that the deal's completion and confirmation are a few days away and that Moncada will likely start in Single-A.
Moncada is expected to report to Red Sox camp Monday, per Pete Abraham of The Boston Globe.
MLB officially declared Moncada a free agent on November 15. At 19 years old, Moncada has more youth on his side than recent Cuban imports Yoenis Cespedes (26 when he signed), Jose Abreu (26) and Yasiel Puig (21). He's also slightly younger than Jorge Soler was when he signed with the Chicago Cubs (20).
In other words, Moncada will likely need time to develop and should have a longer track record, if he reaches his full potential than Cespedes or Abreu.
Moncada was subject to the international bonus pool because he's under the age of 23 with fewer than five years of experience in a professional league, as Passan noted in November. That's why the money might not seem like it matches Moncada's special talents.
Because he is not yet 23 years old and did not play in a Cuban professional league for at least five seasons, Moncada is subject to MLB's international signing guidelines, under which each team is allotted a $700,000 and an additional bonus pool based on the team's record the previous year to be used during the international signing period. The current period started July 2 and ends on June 15.
According to those guidelines, clubs are penalized during the upcoming 2015-16 signing period if they exceed their bonus pools by certain amounts. The Red Sox had already exceeded their bonus pool before this signing and been given the maximum penalty. It's a severe measure that includes a 100-percent tax on their pool overages and prohibits them from signing any pool-eligible player for more than $300,000 during the next two signing periods. Including the penalty for exceeding their bonus pool, Moncada's deal will cost the Red Sox approximately $60 million (bonus plus penalty).
The Red Sox have until July 15 to pay the overage tax and up to three years to pay out Moncada's bonus.
How good is Moncada? He has more upside than Cuban outfielder Rusney Castillo, who just reached a $72.5 million deal with the Red Sox. He's better than Cuban outfielder Yasmany Tomas, who's in the Dominican Republic but is still likely several months away from free agency. If Moncada were eligible for the 2015 draft, he would be the No. 1 overall pick.
Several teams, including the New York Yankees, the Los Angeles Dodgers and the San Diego Padres, were in the race to land Moncada. Joel Sherman of the New York Post shared details of the Yankees' offer, which lost out to the Red Sox's.
"Yankees offered $25M with willingness to go to $27M which is same offered Jorge Soler who went to #Cubs for $30M," Sherman noted. He went on to compare Moncada's reported deal to Alex Rodriguez's remaining contract: "So with tax, #Redsox will pay $63M to Moncada or about what #Yankees owe A-Rod ($61M) for the next 3 yrs."
For the record, Yasmany Tomas signed a six-year, $68.5 million contract with the Arizona Diamondbacks at the winter meetings. For Moncada to already be in that company at his age speaks volumes about his raw talent. Whether he is able to live up to those expectations remains to be seen, but he should have the time and support system to develop.
Due to his hype, opponents will test Moncada on his journey to The Show, but there's no reason to think the American stage will be too big for the young man.
Last edited by KenFougere; 04-04-2016, 02:24 PM.
Last edited by KenFougere; 04-04-2016, 02:28 PM.


Neither of them had the money to pay him back, so he cancelled the debts of both. To put the verse cited in the question in context, as Jesus was reclining at table while dining in the home of a Pharisee named Simon, a woman who was a notorious sinner entered the room with ointment and knelt behind Jesus at His feet. Just as there are certain courtesies guests in our own homes expect, guests in homes of that day would have expected certain courtesies by way of welcome: a kiss of greeting, then water and olive oil to wash and anoint their hands and feet before reclining at the low table to eat. The staff warmly invite you to join them on any or all of these days. I believe in the moment when she saw Jesus Christ, every fear of leaving those grandchildren behind was completely wiped away. The Lord Jesus Christ, who is always nonsensical to a fallen world, miraculously brings the treasure of Christian faith through redemption and relationship one person at a time. Higher Things exists and grows based on donations from individuals and congregations.
What does this passage mean: he who is forgiven little, loves (Luke 7:47 ESV)?
Learn here, that sin is a debt; and all are sinners, are debtors to Almighty God. She had experienced forgiveness and she showed her profound gratitude. " And Jesus answering said to him, "Simon, I have something to say to you. Her sins were great, said Jesus, and the gospel is not a scheme for making us feel good about our sinning selves. They were semi-public events at which neighbours felt free to stand around the sides of the courtyard observing what was going on. He got through that and finely sat down at the table for dinner, and you can imagine the spread at a royal dinner. For Jesus, true prophethood involved getting hurt for sinners by confronting their attackers.
God was considered the ultimate Patron, and the recipients of His power in forgiveness, healing, provision and favor were the beneficiaries. Any sin at all — any lie or theft, any lusting or sexual immorality, any jealousy or malice or anger or drunkenness — makes us sinners and separates us from God. In the contrary case, the forgiveness already granted will be withdrawn, just as represented in the parable of the wicked debtor. I want to share that with my brothers, and sisters, as well as those who have not yet come to know my Jesus. Honestly, it is easier to identify with people who share our experiences.
Therefore, I tell you, her many sins have been forgiven—as her great love has shown. Jesus came and endured divine justice on the cross for our sins and by his blood we have been ransomed for God - forgiven and reconciled. But to whom little is forgiven, the same loveth little. When He spoke of His eternal relation to the Eternal Father, even His more intimate disciples Friedrich Schleiermacher— Selected Sermons of Schleiermacher 1. God is holy and He is great. And now she crashes the party. Any information presented here is intended to encourage women to strengthen their walk with the Lord and any decisions women make are ultimately between themselves and Christ.
And how does our Love change the way we look at one another? She had clearly encountered Him prior to this incident, because she deliberately brings with her the flask of perfume in order to honor Jesus by anointing Him with it. Simon thought he knew about religion. She was standing behind him at his feet, wetting his feet with her tears, wiping his feet with her hair, and pouring ointment on his feet. God poured out His love so that any person who acknowledged Him would be emptied and forgiven, then filled up with the love of God. She undoes her hair and kneels down and wipes his feet with her hair and then with each wipe she caresses his feet. Wherefore, I say vnto thee, her sinnes, which are many, are forgiuen, for she loued much: but to whom litle is forgiuen, the same loueth litle.
When believers struggle with love for others, it may be that they are struggling with a Pharisaical attitude. The eulogium was tenderly timed, for it followed, and was occasioned by the expression, through messengers, of John's doubts of Christ's Messiahship. The woman asked, and she was forgiven. He began to pour his heart out to His father, and it moved me. Let us study to prove ourselves children of Wisdom, by attending the instructions of God's word, and adoring those mysteries and glad tidings which infidels and Pharisees deride and blaspheme.
I have Him now; He plainly knows nothing of the person He allows to touch Him; and so, He can be no prophet. Jesus attacks Simon in public in his own home. What a wonderful change does grace make upon a sinner's heart and life, as well as upon his state before God, by the full remission of all his sins through faith in the Lord Jesus! One owed him five hundred denarii, and the other fifty. When people think that they don't have much sin to forgive, when they refuse to admit that they are sinners, then they're not going to have much interest in the Savior of sinners. The Pharisee approached Jesus as one who was able to stand in judgment over God Himself.
Usually, I'm right there crying with the woman. The liar, the gossip and the murderer are each sinners. However, the blurring together of gospel women is a well-established church practice, dating from the fourth century after Christ. He too had heard Jesus, and had been moved and struck by his words, and, after a fashion, loved him; only the world - his world - came between him and his love, so that it was only a poor, pale reflection of the real feeling after all. Simon invites some of the prominent citizens to the dinner--you know, the good people you'd like to have at a dinner for the visiting teacher.


When preparing your federal tax return using Form 1040 from the Internal Revenue Service (IRS), you will be given an opportunity to increase your standard deduction by checking the applicable boxes on Line 39a. These additional tax deductions are available to taxpayers and their spouses who are age 65 or over and to those who are totally or partly blind in one or both eyes. For each box checked, an additional $1,150 will be added to your 2012 standard deduction.
Line 39a on IRS Form 1040 increases the standard tax deduction.
Check the upper-left-side box on Line 39a if the first person listed on the tax return was born before Jan. 2, 1948. If you are preparing a tax return for a year other than 2012, check this box if the person was 65 before Jan. 2 on the year following the tax return you are preparing.
The elderly enjoy a higher standard deduction.
Check the lower-left-side box on Line 39a if the second person listed on the tax return was born before Jan. 2, 1948, if filing a joint return. If you are preparing a tax return for a year other than 2012, check this box if the person was 65 before Jan. 2 on the year following the tax return you are preparing.
Check the upper-right-side box on Line 39a if the first person listed on the tax return is totally or partly blind in at least one eye. Partial blindness is defined as being unable to see better than 20/200 with glasses or contact lenses or having a field of vision of not more than 20 degrees. A certified statement from an eye doctor or registered optometrist substantiating the blindness is required for your records.
The blind receive a higher standard deduction.
Check the lower-right-side box on Line 39a if the second person listed on the tax return is totally or partly blind in at least one eye if filing a joint return.
Add the number of boxes checked on Line 39a and put the total in the large box at the far right of the line.
What Percentage of Medical Expenses Can Be Used for Personal Taxes?


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Untitled Story, by Tony Martin (story details) External Website
Video recording of interview with Tony Martin which was recorded as part of the Aftermath Project. The project was undertaken by Diversity Challenges (lead partner).
Video credits: Director, Laurence McKeown; Director of Photography, Damian Purcell;…
Untitled Story, by Dawi Roushaan (story details) External Website
Video recording of interview with Dawi Roushaan which was recorded as part of the Aftermath Project. The project was undertaken by Diversity Challenges (lead partner).
Video credits: Director, Laurence McKeown; Director of Photography, Damian…
Untitled Story, by Dominic McGlinchey (story details) External Website
Video recording of interview with Dominic McGlinchey which was recorded as part of the Aftermath Project. The project was undertaken by Diversity Challenges (lead partner).
Untitled Story, by Mark O'Connor (story details) External Website
Video recording of interview with Mark O'Connor which was recorded as part of the Aftermath Project. The project was undertaken by Diversity Challenges (lead partner).
Untitled Story, by Bridie O'Bryne (story details) External Website
Video recording of interview with Bridie O'Bryne which was recorded as part of the Aftermath Project. The project was undertaken by Diversity Challenges (lead partner).
Video credits: Director, Laurence McKeown; Director of Photography, Barry…
Untitled Story, by Jimmy Fox (story details) External Website
Video recording of interview with Jimmy Fox which was recorded as part of the Aftermath Project. The project was undertaken by Diversity Challenges (lead partner).
Untitled Story, by Emmanuel Marley (story details) External Website
Video recording of interview with Emmanuel Marley which was recorded as part of the Aftermath Project. The project was undertaken by Diversity Challenges (lead partner).
Untitled Story, by Will Glendinning (story details) External Website
Video recording of interview with Will Glendinning which was recorded as part of the Aftermath Project. The project was undertaken by Diversity Challenges (lead partner).
Untitled Story, by Reatha Hassan (story details) External Website
Video recording of interview with Reatha Hassan which was recorded as part of the Aftermath Project. The project was undertaken by Diversity Challenges (lead partner).
Untitled Story, by Peter Kavanagh (story details) External Website
Video recording of interview with Peter Kavanagh which was recorded as part of the Aftermath Project. The project was undertaken by Diversity Challenges (lead partner).


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Harry Cheek Net Worth 2018: What is this baseball player worth?
Harry Cheek was a pro baseball player who played Catcher. Cheek was born on April 23, 1879, in Kansas City, Missouri. Cheek died on August 25, 1927, in Redwood City, California. This page will take a closer look at Harry Cheek's net worth.
Harry Cheek Career, Earnings
Cheek batted Right and threw Right. Cheek debuted in the MLB on April 30, By1910 for the Philadelphia Phillies. In all, Cheek played for the Philadelphia Phillies. Cheek's career ended with the Philadelphia Phillies in By
Some of Cheek's most prominent statistics in the MLB included a Games played stat of 2, a At bats stat of 4, and a Hit s stat of 2.
Harry Cheek Net Worth 2018
Baseball player pay can range widely. In Major League Baseball, the average player earns around $3 million per year. Top MLB players can earn $25 million or more per annum, and less successful players make $1 million or less. Outside the MLB, most contracts are worth less than $10,000 a year.
Harry Cheek net worth: baseball salary distribution
So what was baseball player Harry Cheek's net worth at the time of death? Our estimate for Harry Cheek's net worth at death is:
Want to see some related net worth articles? Check out these: Cesar Ramos, Brian Banks, Bill Howerton, Dave Stieb, Larry Hoffman, Norm Larker, Charlie Fritz, King Bailey, Rod Nichols, Charles Bierman, and Sid Schacht.


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Philips' IG Alliance | ULRI-IE/IT Beats Fluoroscopy | Radiology AI's Last Mile
By The Imaging Wire, May 13, 2019
"Nvidia, King's College train robot overlords to spot oddities on radiology scans"
The actual headline that The Register UK used with its coverage of Nvidia's AI partnership with King's College London. AI marketers, this is what you're up against.
Qure.ai – Making healthcare more accessible by applying deep learning to radiology imaging.
Philips and Medtronic's Image-Guided Partnership
Philips took another step towards advancing its high-priority image-guided treatment business, signing an image-guided atrial fibrillation treatment collaboration deal with Medtronic. The alliance combines Philips' KODEX-EPD cardiac imaging and navigation system (acquired through Philips' 2018 EDP Solutions purchase) with Medtronic's Arctic Front Advance cryoablation technology, while leveraging Medtronic's Atrial Fibrillation Solutions division to take the solution to market.
KODEX-EPD helps guide electrophysiologists' cryoablation procedures using dielectric imaging, which creates real-time CT-like 3D images of patients' cardiac structures and reduces surgeons' reliance on X-ray imaging. KODEX-EPD also confirms the positioning of Medtronic's Achieve Mapping Catheter to help visualize pulmonary veins for pulmonary vein isolation (PVI) cryoablation procedures, while Philips is developing the KODEX-EPD's balloon visualization capabilities to further expand its procedure support.
This seems like an ideal image-guided partnership, as it enhances Medtronic's cryoablation capabilities and expands the reach of Philips' KODEX-EPD system deeper within its target market.
ULRI-IE/IT, The Fluoroscopy Alternative
A Duke-led team shared compelling evidence in support of a new image modifier that allows a computer to show real-time movement of an instrument as it is adjusted, mimicking the use of fluoroscopy, but with far less radiation and much shorter procedure times. The image modifier, currently known as ultralow radiation imaging coupled with image enhancement and instrument tracking (ULRI-IE/IT), was studied in 23 randomized trials of nine procedures that require instrument localization, revealing that:
Instrument localization time was 31.2% longer without ULRI-IE/IT assistance
ULRI-IE/IT reduced the total number of images per case by 74.8%
ULRI-IE/IT cut radiation exposure per case by 91.8%
ULRI-IE/IT allowed physicians to place the instrument on their first attempt in 82.6% of trials, and 100% of second trials (vs. 4.65 images with unassisted fluoroscopy)
Although more research is needed, the team strongly supported ULRI-IE/IT for minimally invasive procedures as a way to reduce patient and surgeon radiation exposure and improve efficiency.
Overcoming Radiology AI's "Last Mile" Challenge
A recent Nuance Healthcare Diagnostics Q&A detailed radiology AI's "last mile" adoption challenge and outlined ways that Nuance and radiologists are overcoming these challenges.
The Last Mile Challenge – Radiology AI's "last mile" challenge has similarities with many efficiency breakthroughs that have emerged in different industries throughout history. Radiologists are realizing that AI tools can improve the quality and productivity of their work, but don't believe they have the time to implement these tools.
Last Mile Solutions – Nuance believes that the ability to seamlessly and intuitively integrate AI tools into current radiology workflows is vital to helping radiologists realize the benefits of AI. From a product design perspective, the key for this is to "think comprehensively," such as delivering AI findings before a radiologist has read the study and dictated the report or making sure AI results are available alongside the images from the PACS and history from the patient's EHR.
AI Workflow Integration – Nuance sees simplifying AI development and deployment as key to workflow integration, specifically through a "unified market where developers can reach large numbers of radiology users who can easily discover and purchase new models," like the Nuance AI Marketplace for Diagnostic Imaging. From there, access to the AI marketplace should be "integrated into the radiologist's workflow tools, the worklist, the PACS and the Nuance PowerScribe reporting system" to support solution evaluation and then workflow integration.
The Next Steps – There's growing momentum toward the widespread adoption of AI in radiology workflows, but Nuance still sees challenges related to the AI reimbursement structure, access to diverse training data, and using previously-unavailable AI-generated data in radiology reporting.
Density Notification Laws Not Driving Breast Ultrasound Growth
Research from the University of Washington School of Medicine shared at ARRS and originally reported by Auntminnie.com found that the widespread adoption of breast density notification laws hasn't resulted in a statistically significant increase in breast ultrasound usage.
The researchers found that between 2007 and 2015 ultrasound usage rates increased from 3.9% to 4.2% (1.1% relative increase) and US+DM rates increased from 7.1% to 10% (1.4% relative increase) in states that adopted breast density notification laws. These increases roughly align with previous research from Emory University that found follow-up breast ultrasounds after mammography screenings increased by 1.02% between 2007 and 2014 within states that adopted notification laws.
The UW study suggested that breast ultrasound adoption may increase at more substantial rates in the future. However, this growth may partially depend on how current and future notification laws are designed/redesigned, as the UW study found the most statistically significant breast ultrasound usage increases in states that require that women are specifically informed about their supplemental screening options.
inc42 on Qure.ai
A recent inc42.com profile on Qure.ai provided insights into the company, its growing portfolio of AI solutions, and market strategy.
Creation and Leadership – Qure.ai was formed in 2016 by R&D leader Pooja Rao and CEO Prashant Warier with $30 million in funding from Fractal Analytics, where Warier also serves as Chief Data Scientist. Qure.ai further bolstered its leadership team in March, naming GE Healthcare veteran Chiranjiv Singh as its Chief Commercial Officer responsible for driving its global expansion.
Solutions – Leveraging data from over 7 million images and backed by a number of validation studies, Qure.ai's value proposition is based around diagnosis speed and accuracy. The company works with hospitals, health-centric non-profits, and medical devices companies with integrations in more than 12 countries (e.g. India, Philippines, US, France, Canada, Africa), targeting its qXR chest X-ray product at countries with high rates of TB and positioning its qER head CT solution for emergency departments in developed countries.
Model – Qure.ai's solutions are provided in a pay-per-use model, charging $1- $5 per scan depending on modality, allowing a wide range of healthcare providers adopt AI. Further supporting Qure.ai's AI accessibility vision, its cloud-based solutions have minimal hardware requirements (e.g. $50 Raspberry Pi hardware kit) and are integrated with the 10 most-used radiology imaging platforms.
Challenges – Like many in AI, Qure.ai sees overcoming market resistance and gaining customer and patient trust as keys to adoption. With that, Qure.ai places a major emphasis on ensuring that radiologists trust and see value in its solutions, including enabling interpretability by detailing "why and where the AI algorithm has detected an abnormality."
United Imaging Healthcare announced the FDA clearance of the uPMR 790 HD TOF PET/MR scanner, highlighting its ability to scan a whole body within 20 minutes and perform simultaneous imaging with high-temporal and high isotropic spatial resolution. UIH leaned-in on the uPMR 790's technology in this announcement, specifically its SiPM/LYSO-based PET platform (with 32cm PET FOV, 480 ps timing resolution, 2.8mm NEMA PET spatial resolution) that combines with its 3T MRI to allow "fast simultaneous whole-body PET and MR scans." The system is intended for both clinical (staging, treatment planning, and response assessment) and research (theranostics and neuroscience) applications.
A pair of closely-associated UK research teams published studies that suggest Whole-body MRI (WB-MRI) may perform better than the standard multi-modality imaging approaches for staging colorectal cancer and non-small-cell lung cancer (NSCLC). The two studies found that WB-MRI achieved sensitivity and final decision agreement rates that are close to multi-modality staging (slightly better for colorectal cancer, slightly worse for NSCLC), while reducing patient costs and staging time requirements in both studies.
An American Medical Association survey reveals that, for the first time ever, more physicians work as employees of a hospital system or a practice owned by other physicians (47.4%) than run their own practice (45.9%). This is a big change since physician practice ownership peaked in 1983 (75.8%), but it's not unexpected given the industry's ongoing consolidation trend and the financial incentives that hospitals have to refer patients to hospital-owned practices. This employment trend is, of course, also taking place within radiology.
The latest round of China tariffs kicked-in on Friday, increasing tariffs on $200 billion worth of Chinese imports from 10% to 25%. Although these tariffs largely targeted consumer products, they did include X-ray photographic plates and film and X-ray photographic film in rolls, joining a long list of medical imaging products and components that have been subject to 25% tariffs for nearly a year.
NVIDIA and King's College London announced a partnership to build an AI platform to improve the UK NIH's radiology workflows. The initiative is part of KCL's ongoing King's London Medical Imaging & AI Centre for Value-Based Healthcare project and the latest announcement is directly connected to KCL's fall 2018 adoption of NVIDIA's DGX-2 AI research system and the NVIDIA Clara AI platform.
The American College of Nurses-Midwives (ACNM) announced an alliance with GE Healthcare that will introduce its members to GE's Vscan Extend handheld ultrasound through a series of educational webinars and training sessions. This is the latest example of GE's training-focused approach to POCUS marketing, coming just three months after announcing a POCUS training collaboration with UltrasoundPodcast.com.
One could see why the time-saving practice of using prepopulated default text in radiology reports may lead to biased reporting (radiologists erroneously using prepopulated impressions), a team from Cincinnati Children's Hospital found no evidence of bias or any other negative impacts from using default text. The researchers looked at 248 ultrasound examinations for dysplasia of the hip (DDH – 472 hips) before adopting standardized reporting and studied 225 ultrasound examinations (426 hips) performed after the change, finding that a similar number of hips were diagnosed as DDH Graf 1 (74.4%, 75.4%) and Graf 2a (25.6%, 24.6%) before and after adopting standardized reporting.
The FDA published a pair of X-ray guidance documents including a recommendation intended to make the U.S. X-ray regulation processes more consistent with the International Electrotechnical Commission (IEC) and a second guidance clarifying requirements related fluoroscopy irradiation time, last-image-hold, and emergency mode.
Exact Imaging announced the CE Mark approval of its ExactVu micro-ultrasound system's Abdominal Imaging Release, which includes its new EV5C Abdominal Transducer and Color Flow and Power Doppler capabilities. Exact Imaging suggests that the new solutions allow "urologists to perform complete urological ultrasound assessments including kidney examinations and biopsies, male pelvic and bladder examinations," making it a "total men's health imaging solution."
The British Columbian city of Kamloops may be great for winter sports, but it's not ideal if you need an ultrasound, as a sonographer shortage (2.5 sonographers) has led to 10/12-month ultrasound wait times and forced some patients to drive 1.5-2.5 hours to neighboring cities for US scans. Kamloops may be a unique case, given its rural location, but sonographer shortages have been happening for some time, and considering ultrasound's continued growth and diversification across departments/applications, it's likely we'll hear more talk of sonographer staffing issues going forward (it's also a call for greater ultrasound efficiency).
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Carestream's first OnSight 3D customer, Resurgens Orthopaedics (24 locations, 104 physicians), shared some of the benefits they've experienced from the cone beam CT system in this video, including the importance of weight bearing in surgery decisions, and the system's image quality, ease of use, and fast study time.
Did you know that radiologists' follow-up recommendation rates can vary by between 2.8-fold and 6.8-fold depending on radiology division? Nuance's PowerScribe Follow-up Manager and mPower Clinical Analytics solutions address follow-up inefficiencies by supporting departmental compliance efforts and helping ensure that the patients who received follow‑up recommendations actually return for their scans.
The Focused Ultrasound Foundation's 2018 Year in Review details the impressive research and clinical achievements that took place last year.
We might be in the middle of Stroke Awareness Month, but not everyone is aware that strokes can cause the brain to lose over 30,000 cells for every second the brain goes without oxygen. Qure.ai's qER triage aid detects critical problems in head CT scans in less than 10 seconds, helping doctors quickly prioritize the most urgent stroke and TBI cases.
Did you know that imaging patients are most likely to no-show for their procedures on Mondays and Saturdays? By partnering with Medmo, imaging centers can keep their schedules full, despite the inevitable Monday no-shows.
Tagged: AI, Artificial Intelligence, Breast Ultrasound, deep learning, ExactVu, fluoroscopy, GE Healthcare, image-guided, Medical Imaging, Medtronic, Nuance Healthcare, NVIDIA, PET/MR, Philips, POCUS, Qure.ai, radiologist, radiology, sonographer, Ultrasound, United Imaging Healthcare, Whole-body MRI, x-ray
Walmart-Approved Imaging | Density Debate | A Path to Patient Consultations
Google's Imaging AI | Breast Cancer Predictor | Watson Imaging Goes Live


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The NZ Army is not a conventional Western military. Photo: Getty Images
NOVEMBER 26, 2018 Updated January 15, 2019
Peter McKenzie
Peter McKenzie is a Law and Politics student at Victoria University of Wellington.
How the NZ Army became an iwi
Every few months a disparate group of New Zealanders file into Rongomaraeroa-o-nga-hau e wha, the National Army Marae in Waiouru. They have just made it past the initial hurdle of Army basic training: the gruelling first few days. The group has come to attest - the process of swearing loyalty to the Queen and formally entering the armed services.
Speeches precede the solemn ceremony. High-ranking officers welcome the recruits, and entreat them to consider eachother as comrades. They then explain the significance of what is about to take place. Having attested, they will have a new family: Ngāti Tumatauenga - 'Tribe of the God of War'.
This is what makes the New Zealand Army, a small force with few major deployments, so unique. It is not a conventional Western military. In 1994 it transformed itself into Ngāti Tumatauenga: an iwi created by, with and for the state.
The Army hoped this would facilitate better integration of Māori knowledge and culture into its organisational ethos. In the background looms one question. Is this genuine bicultural integration or merely the co-option of Māori culture?
Ironically, the history of Ngāti Tumatauenga begins with a white officer named Anthony Birks. Birks grew up in the relatively white and rural South Island of New Zealand in the mid-20th century. He attended the Royal Military Academy at Sandhurst in England and was commissioned as a second lieutenant. It was a conventional journey for promising young officers in the 19th and 20th centuries.
It was only upon returning to New Zealand from England that Birks came into contact with Māori. Steve Bethell, the cultural advisor at the Army Marae, remarked that "[Birks] joined the Army believing Māori were extinct. When he climbed off the train [at Waiouru Military Camp] at 2 o'clock in the morning, brown people were yelling at him [to direct him which way to go]. And he met Māori for the first time in his life." It was a confronting awakening.
Birks gained an abiding appreciation for the practices of his Māori compatriots while serving overseas in Malaysia and Vietnam. Steve Bethell recounted how upon coming out of the jungle, all Māori in the camp would congregate to "make sure that everyone came home. If they didn't come home then they would listen to the reason why … and they could grieve for one of their own. At the end of that grieving … people would add 'my baby brother had his 21st' or 'my baby was born', so that into this world of darkness you suddenly had this shining light of happiness."
By 1994 Birks had been promoted to Chief of General Staff, the highest position in the NZ Army (the position is now 'Chief of Army'). That year he decided to attend the annual meeting of the 28th Māori Battalion. Lieutenant-General Bernard Freyberg, commander of the 2nd New Zealand Division, once noted that 'no infantry battalion had a more distinguished record, or saw more fighting, or, alas, had such heavy casualties as the Māori Battalion.'
At the meeting Birks made a surprising request. He asked for permission to construct a permanent Army Marae and transform the New Zealand Army into an iwi - Ngāti Tumatauenga. Most interestingly, Birks wished for Ngāti Tumatauenga to have equal tribal status to conventional iwi.
Just as surprisingly, the 28th agreed. Working alongside Birks, they sent messages to iwi across New Zealand. The Māori Queen gave her assent, as did the iwi which surrounded Waiouru; Ngāti Tūwharetoa, Ngāti Kahungunu, Ngāti Maniapoto, Ngāti Tuhoe. And so Ngāti Tumatauenga was born.
It was an astonishing reversal. The NZ Army evolved out of the British troops deployed during the 19th century New Zealand Wars to suppress Māori dissidents and appropriate Māori land. Most successful officers were white New Zealanders and, similar to Birks, had studied at prestigious English military institutions. To them a good military was an English military. In that world Māori soldiers felt like "third-class citizens" said Steve Bethell.
"Our marae faces the setting sun. Every other marae in NZ faces the rising sun to welcome the new day. If every marae faces there, who guards against the darkness?"
Nonetheless over a few months in 1994, the NZ Army transformed into an extension of the culture which it had played a part in suppressing.
That transformation has had little impact on the NZ Army's combat practices. The NZ Army has seen little modern relevance in the traditional hand-to-hand warfare of early Māori history. Similarly, the guerilla tactics utilised by Māori to great effect in the New Zealand Wars has been deemed of little independent value to an Army which has absorbed its harsh lessons from deployments in Malaysia, Vietnam and Afghanistan.
But the transformation has had a profound impact on the culture and ethos of the NZ Army. Every soldier, regardless of ethnicity, is inducted into Ngāti Tumatauenga. Recruits spend nights on the marae being taught the whakapapa of their new iwi. As they sleep under the creaking roof they sink their roots into what will become their spiritual home. It can be a transformative experience. "I had never considered that I would ever belong to an iwi," explained one enlisted soldier with no Māori ancestry. "Knowing Ngāti Tumatauenga is my iwi gives me a sense of belonging... I am proud to say I belong to Ngāti Tumatauenga. It gives me pride in my country, my country's history and in myself." That sense of belonging supports the strong ties of comradeship among NZ Army personnel.
That shared cultural belonging was poignantly expressed in this year's repatriation of NZ Defence Force personnel who had been buried overseas. The remains of 27 personnel who had served in Malaysia and Singapore were exhumed and blessed under the supervision of kaumātua, and the Defence Force committed to complying with appropriate tikanga.
The remains were flown home by Air New Zealand in August, and were greeted by waiata which echoed across the tarmac of Auckland Airport. A fleet of hearses then carried the remains through a gauntlet of serving personnel. On one side Defence Force personnel silently stood to attention, and on the other a mix of uniformed soldiers and elders wearing traditional Māori garments performed a rousing haka. Traditional Māori practice and customary military ceremony merged into a moving farewell to the fallen.
The NZ Army's transformation into Ngāti Tumatauenga has also brought significant practical benefits. The Army Marae organises courses teaching te reo, tikanga, Māori culture and even the use of traditional weaponry. This understanding of Māori culture supports the work of Defence Force personnel overseas.
Commander David Ledson and the HMNZS Waikato is a good example. The HMNZS Waikato was approaching Bougainville in Papua New Guinea. Confused and concerned as to why the HMNZS Waikato was approaching, local residents grabbed weapons and began threatening the vessel. By going ashore with his Māori advisory group, performing a haka and engaging in cultural discourse, Commander Ledson demonstrated the HMNZS Waikato's lack of hostility and avoided a major international incident. The fact that this took place in 1990, even before the creation of Ngāti Tumatauenga, is thought to be indicative of the potential value of a concerted effort to inculcate Māori knowledge in the activities and practices of the New Zealand Defence Force.
Of course the integration process still faces challenges. The value of Māori knowledge and the difficulty which some NZ Army personnel have adjusting to a genuinely bicultural reality were both exemplified in comments made by Brigadier Roger Mortlock, the New Zealand Commander of peacekeeping forces in Bougainville during 1998. Mortlock declared that he had two assets which would be "main weapons in our arsenal." The first was a squad of Māori cultural advisors who he hoped to deploy as liaisons with locals. The second was a shipment of guitars which the cultural advisors could use; a comment which plays into common stereotypes about musical Māori.
Cliched comments like these make it possible to argue that Ngāti Tumatauenga represents not integration, but co-option of an indigenous group and its knowledge. The fact that Māori make up around 20 percent of enlisted soldiers but only around 8 percent of commissioned officers is another indicator that the Army may be unfriendly to Māori trying to enter command and management positions.
Yet few commentators espouse such concerns. Dr Debbie Hohaia, an academic at Charles Darwin University, has written positively about Māori cultural experiences within the New Zealand Defence Force. In her paper In Search of a Decolonised Military: Maori Cultural Learning Experiences in the NZDF, Dr Hohaia concluded that while "a deeper understanding of Māori epistemologies and kaupapa is needed at every level of [the Defence Force]", she believes that "the New Zealand Defence Force's journey towards biculturalism" has made significant progress towards the goal of a decolonised military where Māori knowledge and practices are as credible and valuable as their Western equivalents.
Many see Ngāti Tumatauenga as another step towards the fulfilment of the promise of bicultural partnership made in New Zealand's founding document, the Treaty of Waitangi. One current enlisted soldier with Māori ancestry explained that "Ngāti Tumatauenga represents the amalgamation of the Imperial soldier's spirit with the mana of the Māori warrior. This is a positive reflection of the partnership principle of the Treaty of Waitangi, giving me pride in using Ngāti Tumatauenga in my pepeha."
Perhaps there would be more controversy if Ngāti Tumatauenga's nature and origins were better known. But for those in the know, such as New Zealand's soldiers and academics like Dr Hohaia, the NZ Army's creation of Ngāti Tumatauenga is a genuine, laudable and effective attempt to integrate Māori knowledge and culture into the Army's ethos.
Regardless those debates are far from the mind of visitors to the Army Marae in Waiouru. Instead, as they exit through gates adorned with carvings of Ngāti Tumatauenga's ancestors, visitors are confronted by Mt Ruapehu towering on the horizon.
That orientation, as with every other aspect of Ngāti Tumatauenga and the Army Marae, is unique. "Our marae faces the setting sun," noted Bethell. "Every other marae in NZ faces the rising sun to welcome the new day. If every marae faces there, who guards against the darkness? We have the back of New Zealanders during those hours of darkness… That is our sole responsibility: to protect our own. We face the darkness because that is from where the enemy will come."


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Update: 01 January, 2023, 13:31
Advocate: NCDC's 'unscientific position' on vaping to make quit smoking a challenge
A new statement put out by the Non Communicable Disease Control Programme recently expressed "deep concern" about the availability of e-cigarettes in the country and warned of "serious public health consequences in the future".
But harm reduction advocates who support using e-cigarettes, popularly known as vapes in the country, as quit smoking aid argue that it is a significantly less harmful alternative to combustible tobacco cigarettes and has been proven to be an effective quit smoking tool.
The new statement, signed by Prof Dr Mohammad Robed Amin, Line Director of the NCDC under the Health Ministry's Directorate General of Health Services (DGHS) stated that vapes pose respiratory disease risk for public health in the long run. "There has been no evidence of e-cigarettes being less harmful than regular cigarettes. Research shows that e-cigarette smoking along with tobacco cigarette smoking increase risk of heart attack by 5 fold," the statement read.
Schumann Zaman, president of Bangladesh electronic nicotine delivery system traders association (BENDSTA)said that the NCDC statement does not provide any source for the heart attack claim.
Zaman said that there is in fact very good evidence that vaping is less harmful. "A scientific review by the UK Health Security Agency (formerly Public Health England) found that vaping is 95% less harmful than regular cigarettes."
Zaman said that Bangladesh's health authority should properly look into the vape regulation framework adopted by developed countries like the UK and New Zealand, which officially endorse vaping as a quit smoking tool.
Vaping as a smoke cessation tool is very effective, Zaman claimed, which is why countries like the UK recognise it as a viable quit smoke aid. "A recent scientific review by the highly prestigious Cochrane Library concluded that vapes are a more successful quit smoking tool than traditional therapies like nicotine patches and gums," he said.
Prof Dr Mohammad Robed Amin of NCDC said that vapes were meant to be used for those who did not respond to other quit smoking methods. But it is not a tool that can be used widely. However he did not elaborate on the available quit smoking methods popular in Bangladesh.
"We don't know the long term effects of these devices. Why should we put our next generation in danger in the name of quitting smoking?" Dr Amin said. Just because it is legal in a developed country, he said, does not mean that Bangladesh should blindly follow it.
Even though the vaping advocate likes to cite the Public Health England review, these results were never published in any reputable journal, Dr Amin claimed without any prior knowledge on any of the existing research.
"If we hear the name of the UK, we are prepared to accept anything. This is a problem. There is no evidence that vapes are less harmful," he said.
Zaman claimed that NCDC's position is "unscientific" and makes smoking cessation difficult for smokers in the country.
"It makes no sense to dismiss the UK's highest health authority when practically every doctor in Bangladesh gets their higher medical specialisation qualification from the UK," Zaman said.
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Our Lives Flashed Before Our Eyes During the Avalanche... of Bubbles
If you've been listening, you know that we are part of a big family… I'm the oldest of 7 in a family of five girls and two boys and our mom was the oldest of eight in a family with 3 brothers and 5 girls and these were the people who taught us that if you weren't laughing at life's craziness, you were doing it wrong.
A big extended family also came with other perks – one was cousins! And, lots of them! Two, we had big family get-togethers filled with lots of laughter, smart-assery and shenanigans and three, our summers were filled with staying with our cousins at their various houses or having them come to stay with us! I'd venture a guess that for a lot of us cousins in our large extended family, those family swaps during the summer months hold some of our best and most unforgettable memories. We didn't go on family vacations, so going to a cousin's house in the far off land of Wisconsin for a stay was a big deal!
Today's episode as told by our sister Erin and our cousin Heather is about one of those summer stays with our Aunt Annie, who was, as Heather calls her… "the fancy aunt". I'm going to take a moment to give Annie a should out and wish her a belated 75th birthday! I saw her not that long ago and she's still our fancy aunt who still knows how to have good time!
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-Thanks to our Storytellers: Heather Vaudreiul and Erin Smith
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Produced, edited, written and hosted by Kim A. Flodin, with editing help from Kari Flodin.
Welcome to What in the Hell House - AD FREE with a BONUS!
Happy Halloween! Today it's all about tricks and treats! Our treat for you today is an AD-FREE show and if you're up for treating us, we love cookies from ko-fi.com…It's a super easy way to support the show and we rely on you to help us keep running…. So don't be a trickster, be a treater and help us out at Kofi.com/howinthehell! And, we have a BONUS for you - be sure to listen all the way through to hear the November episode of How to Fall in Love... with Yourself Monthly Toolkit... the other podcast I release monthly!
We have a terrifying show for you today all about the house we grew up in. So, Jenny and Kari are here to share a collection of creepy tales that happened in our childhood home and some are being told here for the very first time!!!!
Story 1: Growing up in a haunted house can make you feel like your losing your mind! There always seemed to be things happening that just didn't quite make sense and all seven of us kids learned to cope by keeping our lips zipped and pretending that things were okay…Jenny shares two terrifying memories from when she was just a little kid!
Story 2:The house we all grew up in was large, it was an old Victorian that was built in around 1880 and had a distinctly Gothic vibe especially after our mom painted it a shade of gray that was almost black, but it was still only a 3 bedroom 1 ½ bath house and we had 7 kids, 2 parents and an assortment of dogs, cats, birds, and more living there, we also had the most kids on the block, so our house was the headquarters for every kid in the neighborhood – it was also, as you've heard, haunted as hell. Kari tells a story of something that somehow moved in the night.
Story 3: Our last story is all about the man in the house… and no, I'm not talking about Crazy Larry, also known as our dad… no there was another man and both Jenny and Kari had startling and scary encounters with him!
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-Thank you YouTube Free Music Audio Library & Silent Partner for our theme song, 7th Floor Tango, ad music, Blue Skies, scary music, Slow Shock http://bit.ly/youtubeHITH