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CNT Hackathon encourages collaboration and interdisciplinary thinking to develop neurotechnology
Aleenah Ansari
Derived from a course for students to create solutions to neural engineering problems, the Center for Neurotechnology (CNT) Hackathon is a weekend-long event where student teams have 36 hours to create novel technology that fulfills the CNT mission: Improve health and function by engineering neural devices.
"This hackathon is a chance to [focus on] neural work with engineering principles. I think it's fun to commit yourself to a project for a weekend and have that to focus on," said Jackson Chin, a hackathon participant and senior in bioengineering at the University of Washington (UW).
This year's hackathon featured five teams representing institutions across the country including the UW, Massachusetts Institute of Technology, Georgia State University, Morehouse College, and Carnegie Mellon University. Participants represented disciplines including neuroscience, computer science, bioengineering, mechanical engineering, and physics, with students at undergraduate and graduate levels.
"Neural engineering is such a broad, interdisciplinary field," said Richy Yun, a third- year PhD student in bioengineering and hackathon coordinator at the UW. "The whole point is to bring in people with different backgrounds and ideas together outside of lab settings and give them an opportunity to work on something and solve problems."
Using virtual reality and mixed reality to address neural engineering problems
Unlike traditional hackathons that focus on coding, this hackathon invited its participants to create a device with a hardware and software component.
Yun emphasized that developing something with hardware and software in mind is an integral part of neural engineering.
"My experience in a lab involves a lot of coding and analysis, but half of what I do when running experiments is troubleshooting to come up with ad-hoc connectors and stimulating devices and wires," Yun said. "I think it's important to understand how all of that works together, so in the end, you can do the analysis."
Yun wanted to encourage creativity, so he chose the theme of virtual reality (VR) and augmented reality (AR). Participants were required to analyze bio signals through methods like electromyogram motion capture in their project. Each team received a Microsoft Mixed Reality Headset and access to equipment like arduinos and haptic feedback devices that can measure sensory feedback in response to a task.
Chin's team focused on using VR to address phantom limb pain, a phenomenon that can occur in people with an amputated limb because of a combat injury, accident, or disease like diabetes. As a result, neurons can rearrange themselves in ways that bring pain, and it affects 80 percent of people with an amputation. One treatment option is called mirror therapy, a reflective illusion where the patient perceives their existing limb as their lost limb and by relaxing their arm muscles induces pain relief.
The goal of the team's project was to use a VR headset and Myo gesture control armband to create a virtual experience that replicated mirror therapy.
For some participants, creating a product for an end user can be very different than doing research, which focuses on understanding a subject in-depth. The hackathon invites participants to think about how to create a product that can fit into someone's life.
"Most of my lab work is focused on furthering research for research's sake. I do computational biology and image processing, so I build tools to help research become better," Chin said. "Here, it's focused on product development to create something meaningful that can help people."
Moreover, the Hackathon's short timeframe encouraged Chin to focus on one project, as compared to his work in bioengineering and the research lab, where he typically has several projects in process at one time.
"No matter what you do, you have deadlines," Chin said. "It's nice to have the experience of working with condensed work schedules and limitations, and learn adaptability through it.
Sharing projects with a panel of judges and the CNT community
On the final day, teams presented their prototypes to a panel of judges from academia and industry, members of the CNT community, and the public. The judges and audience asked questions about the cost of the student's devices, opportunities for future iterations, liability, and how projects could be streamlined and packaged for commercial use.
"Where else do you go and see neural engineering products? It's cool to see how a combination of departments can come up with something," Yun said. "It also shows what neural engineering could look like at different steps of your career."
Projects were judged on a range of factors such as feasibility, complexity, marketability and consideration of ethical implications. These factors could be used to assess the viability of these ideas in the market.
"[Considering the ethical implications is] an important value to instill in the next generation of engineers, especially when it comes to patient-facing devices," said James Wu, a sixth year PhD student in bioengineering at the UW and former Hackathon coordinator.
Chin's team. VR-tuoso Phantastic, took a collaborative approach to developing their project. Amir Gull, a computer science and engineering student at Southwestern College, brought in his knowledge about how to build video games, Chin leveraged his experience with reading muscle movements and processing signals, and Tomasz Fraczek, a first-year neuroscience graduate student at the UW, facilitated the connections between the user's muscles, computer, and the VR game.
Similarly, another team focused on gamifying physical therapy with Handii, a real-time interactive hand and gesture device. They envisioned it being used to help people develop their range of motion and fine motor skills.
Team WordMagic focused on addressing communications problems that arise after a stroke, which impact 25 to 40 percent of stroke survivors. Their solution was to design a device that shares visual prompts via a Microsoft HoloLens and converts gestures and written words to speech.
Hackathon participants, Julien Bloch and Sandra Lara, focused on a different problem space. They proposed using biofeedback and VR for surgical training with the goal of reducing error reduction. When presenting, they reflected on the ethical considerations of who would own the biometric data, and whether or not the system was designed to ensure the well-being of the patient or surgeon.
The winning team was Rehabilitation for Independent Seated Extension (RISE), which included members, Preston Pan, Karley Benoff, and Melchizedek Mashiku. They created a device that supported strength, stability, and balance for people who are recovering from spinal cord injuries. Their project used magnetometry data and EMG signals, to measure bio signals from the trunk and create immersive AR encouragement for the user to sit-up. The judges commented that RISE's project was addressing a clear need and seemed the most viable for commercial use in its current form.
Ultimately, the CNT Hackathon was a valuable experience for participants to design solutions to neural engineering problems in a collaborative and forward-thinking way.
"For contestants, the hackathon is demystifying neural engineering and its component features, as well as demystifying coding and signal processing," Wu said. "For the people who attended, it's a first-pass exposure to what neural engineering is."
For more information about the 2019 CNT Hackathon, contact Richy Yun.
Engage and Enable Blog
Karley Benoff, Hackathon participant and UW graduate student in mechanical engineering, adjusts the prototype her team, Rehabilitation for Independent Seated Extension (RISE) designed.
Team RISE, made up of Hackathon participants Preston Pan, Karley Benoff, and Melchizedek Mashiku created a device that supported strength, stability, and balance for people who are recovering from spinal cord injuries.
2019 CNT Hackathon winners, Team RISE, pose with their trophies in-hand.
Jackson Chin, Tomek Faczek and Amir Gull, members of Team VR-tusoso Phantastic, demonstrate their virtual reality platform that allows people who have amputation below the elbow to see their missing limb and practice exercises that relieve phantom limb pain.
Melanie Loppnow demonstrates how her team gamified physical therapy with Handii, a real-time interactive hand and gesture device.
Members of team WordMagic focused on addressing communications problems that arise after a stroke, which impact 25 to 40 percent of stroke survivors.
Hackathon participants, Julien Bloch and Sandra Lara (not pictured), put forward a proposal that used biofeedback and virtual reality for surgical training with the goal of reducing error reduction.
The 2019 Hackathon participants posed for a group photo after the event.


Versailles Gardens - Fountain Night Show Only: Display ends at 11:05pmUpgrade: Fountain Night Show + Serenade: Dance show finishes at 7:50pm. Enjoy a break before the fireworks display commences from 8:30pm - 11:05pm.
Experience Versailles Gardens at night, when they are transformed by music and fountain displays. Guided by the sound of Baroque music, use your independent ticket to explore the illuminated groves and the fireworks display. Upgrade your evening with a visit inside Versailles Palace to see a Baroque dance performance called Serenades Royales in the State Apartments and the Hall of Mirrors.
During the summer months, the Gardens of Versailles become even more special when the gates open for a night fountain show. When the sun sets, the fountains inside the UNESCO World Heritage-listed gardens transforms with lights and pyrotechnics that are synchronized with classical music from a Baroque-style orchestra.After redeeming your ticket voucher at the entrance of the Gardens of Versailles, you'll be directed through the gardens to the best area to watch the show. For approximately 15 minutes at the end of your evening in the gardens, the Tapis Vert, a long grass carpet, is lit up by a fireworks display. This is accompanied by the French Baroque music of German conductor and violinist Reinhard Goebel and his orchestra, the Musica Antiqua Köln.When the fireworks display has ended, you will be guided back to the entrance of the Gardens of Versailles.Upgrade: Fountain Night Show + Serenade:To complete your evening, arrive early and head inside the Palace of Versailles to see a Baroque dance show. Baroque musicians and dancers – all wearing traditional, period costumes – guide you on a musical journey through the State Apartments in the Palace. Admire the fabulous Hall of Mirrors while watching typical Baroque dances such as the Sarabande, Menuet, and Chacrone from a group of musicians and dancers from La Compagnie de Danse de l'Eventail.


After placing the leaf with its passenger onto the soil of a houseplant I lay a very tiny piece of apple nearby. I am not surprised when I check back on my tiny pet; I find it sharing a meal with a few of its buddies. Eventually, weather permitting, they are released outside.
It must have tried to fly off because the next thing I knew it was upside-down in the drain to the sink. To avert the impending doom I placed my fingertip nearby for it to latch on to, which it did, and pulled it to what should have been safety.
But my elderly hands desensitized by arthritis had moved in too hard and unintentionally injured the little creature. While lifting it back to the sill it slowly released itself from my finger and fell on to the counter and stopped moving. I was disheartened and chastised myself for being upset…it was JUST a bug for goodness' sakes!
Image: Coccinella by Danielemusella, morguefile.com.


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LAMC2 as a prognostic biomarker in human cancer: a systematic review and meta-analysis
Tao Fu1,2,
Jun-Xia Liu1,2,
Juan Xie1,2,
Zhen Gao3,
http://orcid.org/0000-0001-6987-9947Zhenshan Yang4
1Chongqing Clinical Research Center for Reproductive Medicine, Chongqing Health Center for Women and Children, Chongqing, Chongqing, China
2Chongqing Key Laboratory of Human Engineering, Center for Reproductive Medicine, Women and Children's Hospital of Chongqing Medical University, Chongqing, Chongqing, China
3College of Animal Veterinary Medicine, Northwest A & F University, Yangling, China
4College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong, China
Correspondence to Zhenshan Yang; le1730{at}126.com
Objectives Accumulating evidence suggested that the laminin γ2 (LAMC2) expression level was upregulated in various cancers. However, the potential prognostic value of LAMC2 in cancers remains unclear. We conducted a meta-analysis to clarify the association of LAMC2 expression with prognosis.
Design We searched Embase, Web of Science and PubMed (up to 25 November 2021) to collect all eligible studies, and meta-analysis was performed to interpret the association of LAMC2 expression with clinicopathological parameters, overall survival (OS), disease-specific survival (DSS) and progression-free survival (PFS).
Eligibility criteria for including studies We included studies that investigate the relationship between LAMC2 and prognosis of cancers, patients were divided into two groups, and associations of LAMC2 expression with clinicopathological features were described.
Results Seven studies were finally included. We found that increased LAMC2 expression was significantly associated with lymph node metastasis (log OR 0.88, 95% CI 0.38 to 1.38, p<0.001), tumour-node-metastasis stages (log OR: 0.95, 95% CI 0.39 to 1.50, p<0.001) and tumour status (log OR 1.26, 95% CI 0.84 to 1.68, p<0.001), but not with age (log OR −0.05, 95% CI −0.37 to 0.27, p=0.75) or gender (log OR −0.07, 95% CI −0.52 to 0.38, p=0.75). In addition, higher LAMC2 expression was found to be significantly associated with OS/PFS/DSS (HR 1.85, 95% CI 1.31 to 2.40, p<0.001). A similar result was found in The Cancer Genome Atlas database. High LAMC2 expression was significantly associated with OS in lung adenocarcinoma, mesothelioma, skin cutaneous melanoma, neck squamous cell carcinoma and brain lower grade glioma.
Conclusion Our results suggested that higher LAMC2 expression was correlated with worse survival, lymph node metastasis, tumour-node-metastasis stages and tumour status. This study was subject to inherent limitations, but the results presented here provide insights regarding the potential use of LAMC2 as a biomarker for human cancer.
Study registration researchregistry.com (researchregistry1319).
Adult oncology
All data relevant to the study are included in the article or uploaded as online supplemental information.
This systematic review and meta-analysis provide comprehensive literature published up to November 2021 was performed in Embase, Web of Science and PubMed.
This study adheres to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.
Additional data sources, such as grey literature, were not searched.
Laminins are trimeric proteins composed of α, β and γ chains, which are the main component of basement membranes.1 Mammalian genome encodes five α chains, four β chains and three γ chains.2 Loss-of-function studies show that most laminin mutants are embryonic lethal.3 Laminins are involved in various biological processes, including cellular phenotype maintenance, adhesion, migration, growth and differentiation in vivo and in vitro.4 5
In recent years, laminin γ2 (LAMC2) has attracted increasingly attractive because of the aberrant expression of LAMC2 in various cancer. The LAMC2 expression was significantly upregulated in colorectal cancer tissues compared with adjacent normal tissues, and high LAMC2 expression is known to be associated with poor patient prognosis.6 Furthermore, overexpression of LAMC2 has been reported in pancreatic ductal adenocarcinoma,7–11 non-small cell lung cancer,12 penile squamous cell carcinoma,13 ovarian cancer,14 oral tongue squamous cell carcinoma,15 cholangiocarcinoma16 and oesophageal squamous cell carcinoma,17 leading to poor clinicopathological features and short survival time.
However, individual studies may be inadequate and inaccurate due to their small sample and study design. To date, there was no meta-analysis has been performed to investigate the relationship between LAMC2 and the prognostic value. Therefore, we performed a comprehensive meta-analysis to assess the correlation between LAMC2 and survival outcomes and clinicopathological features in human cancers.
This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines18 (online supplemental table S1).
No patient was involved.
A literature search was conducted in Embase, Web of Science and PubMed (up to 25 November 2021). The keywords were (laminin C2 OR LAMC2 OR laminin subunit gamma 2) AND (prognosis OR prognostic OR survival). The detailed search strategy is in online supplemental file 1. The reference lists and citation sections of relevant studies were also screened for additional eligible studies.
Study selection
Studies that met the following criteria were included in the meta-analysis: (1) study of the relationship between LAMC2 and prognosis of cancers, (2) patients were divided into two groups: high LAMC2 expression and low LAM2 expression group, and (3) associations of LAMC2 expression with overall survival (OS) and clinicopathological features were described. The exclusion criteria in our meta-analysis were as follows: (1) case reports, letters, reviews, editorials and expert opinions, (2) studies published non-English language, (3) non-human studies and (4) studies without sufficient available data.
The Newcastle-Ottawa Scale (NOS) criteria were used to assess the quality of the eligible studies.19 The NOS contains nine items that include selection, comparability and outcome for studies. When the NOS score was ≥6, the study was considered high quality.
Two authors (TF and ZY) performed the data extraction independently. Disagreements were resolved by discussion and consensus with the third author (JX). The following information from the included studies was collected: the first author's name, publication year, country, number of cases, cancer type, the detection method of LAMC2, clinicopathological features and survival outcome. When multivariate and univariate analyses were simultaneously reported, only the former was extracted. If studies only provided Kaplan-Meier curves, the survival data were extracted from the graphical curve and calculated HR and 95% CI were reckoned using the published method.20
Public data and tools
The web-based tool named Gene Expression Profiling Interactive Analysis (GEPIA) was used to analyse associations between LAMC2 and clinical outcomes.21
We used Stata MP V.16 software (Stata) to perform statistical analysis. Log OR and 95% CI were calculated for the association of LAMC2 expression and clinicopathological characteristics. The prognostic role of LAMC2 expression in OS, disease-specific survival (DSS) and progression-free survival (PFS) was evaluated through HR with 95% CI. The statistical heterogeneity among the studies was analysed by using I2 test and Q test. When significant heterogeneity (I2≥50%, p<0.05) was observed, the random-effects model was chosen. Otherwise, the fixed-effects model was used. The Egger's test and Begg's test were used to assess the potential publication bias. We conducted a sensitivity analysis to explore the stability of the overall meta-analysis results. p<0.05 was considered as statistically significant.
Study identification and characteristics
As is shown in figure 1, a total of 7 studies with 1056 patients with cancer were included in this meta-analysis satisfied the inclusion criteria.6 7 13 16 17 22 23 The publication period ranged from 2017 to 2021. All of our included studies had high quality with NOS ≥6. The included studies addressed six different cancer types: oesophageal squamous cell carcinoma (n=1), pancreatic ductal adenocarcinoma (n=2), cholangiocarcinoma (n=1), papillary thyroid cancer (n=1), colorectal cancer (n=1) and penile squamous cell carcinoma (n=1). The main characteristics of the seven studies are summarised in table 1.
Characteristics of studies included in this meta-analysis
Flow diagram of the literature search and selection.
Relationship between LAMC2 expression and clinicopathological parameters
We evaluated the relationship between LAMC2 expression and clinicopathological parameters in various cancers. As shown in figure 2A,B, there were three and six studies describing patients of age and gender, respectively. The pooled analysis demonstrated that there was no significant association between LAMC2 expression and age or gender. High expression of LAMC2 was significantly associated with lymph node metastasis (LNM) (log OR 0.88, 95% CI 0.38 to 1.38, p<0.001, figure 2C) and tumour-node-metastasis (TNM) stage (log OR: 0.95, 95% CI 0.39 to 1.50, p<0.001, figure 2D). There was significant heterogeneity among these studies (I2=59.61%, p=0.02; I2=60.16%, p=0.03), and thus the random-effects DerSimonian-Laird model was adopted. A total of four studies evaluated tumour status according to LAMC2 expression. No statistically significant heterogeneity was found among the studies (I2=36.00%, p=0.20); thus, the fixed-effect Mantel-Haenszel model was adopted. As shown in figure 2E, high expression of LAMC2 was significantly associated with tumour status (log OR 1.26, 95% CI 0.84 to 1.68, p<0.001). This finding suggests that high LAMC2 expression is associated with clinicopathological features.
Forest plots of studies evaluating the relationship between LAMC2 expression and clinicopathological features. (A) LNM, (B) TNM stage, (C) Tumour status, (D) Gender, (E) Age. LNM, lymph node metastasis; TNM, tumour-node-metastasis.
Relationship between LAMC2 expression and OS/PFS/DSS
There were 5 studies including 872 patients presenting the relationship between LAMC2 and OS/PFS/DSS. Due to no significant heterogeneity being found among studies (I2=0.00%, p=0.83), the fixed-effect inverse-variance model was adopted to estimate the pooled HR and 95% CI. The pooled HR indicated that the expression of LAMC2 was negatively associated with OS/PFS/DSS (HR 1.85, 95% CI 1.31 to 2.40, p<0.001, figure 3A), which demonstrated that LAMC2 was a risk factor for the prognosis of patients with cancer. In addition, sensitivity analysis was performed to determine the effect of individual studies on the OS/PFS/DSS. It revealed that no single study altered the pooled LAMC2 HR result significantly (figure 3B). This suggested that the result of the meta-analysis was stable.
The relationship between LAMC2 expression and OS/PFS/DSS. (A) Forest plot for the meta-analysis of OS/PFS/DSS. (B) Sensitivity analysis for LAMC2 expression with OS/PFS/DSS. (C) Funnel plot for the meta-analysis of OS/PFS/DSS. (D) Egger's graph for analysing publication bias. DSS, disease-specific survival; OS, overall survival; PFS, progression-free survival.
Analysis of publication bias
Funnel plot (figure 3C), Begg's test and Egger's linear regression test (figure 3D) were used to assess publication bias. The results showed that the funnel plots scatter symmetrically. The statistical tests showed p values were greater than 0.05 (Begg's test: p=0.4624; Egger's test: p=0.329). Thus, there was no obvious publication bias in the prognostic meta-analysis.
Validation of TCGA data set results
To validate our result, we retrieved LAMC2 expression data and clinical data from the TCGA dataset. As shown in figure 4A, LAMC2 was increased in colon adenocarcinoma (COAD), lymphoid neoplasm diffuse large B-cell lymphoma, oesophageal carcinoma, head and neck squamous cell carcinoma (HNSC), lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC), determined using a log2FC cut-off of 1 and a p value cut-off of 0.01. A total of 9502 patients with urinary, digestive, female reproductive, respiratory and blood systems cancers were included in the survival analysis from the TCGA database. According to the expression of LAMC2, the patients were divided into high and low groups using the median score as the cut-off by GEPIA.21 The results showed that higher LAMC2 expression was correlated with worse survival (figure 4B). We also explored the prognostic role of LAMC2 in different cancer types. As shown in figure 5, LAMC2 expression was significantly associated with OS in LUAD (figure 5A), mesothelioma (MESO, figure 5B), skin cutaneous melanoma (SKCM, figure 5C), HNSC (figure 5D) and brain lower grade glioma (LGG, figure 5E). However, LAMC2 expression was not related to OS in LUSC (figure 5F).
The expression of LAMC2 in TCGA database. (A) LAMC2 expression in colon adenocarcinoma (COAD), diffuse large B-cell lymphoma (DLBC), oesophageal carcinoma (ESCA), head and neck squamous cell carcinoma (HNSC), lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). *p<0.01. (B) OS rate of LAMC2 expression in TCGA database (n=9502). Grey boxes indicate normal, and red boxes indicate tumour. N, normal; OS, overall survival; T, tumour; TCGA, The Cancer Genome Atlas.
Kaplan-Meier curves showing the prognostic value of LAMC2 in the TCGA database. (A) LUAD, (B) MESO, (C) SKCM, (D) HNSC, (E) LGG, (F) LUSC. P values were calculated using the log-rank test. HNSC, head and neck squamous cell carcinoma; LGG, lower grade glioma; LUAD, lung adenocarcinoma; MESO, mesothelioma; SKCM, skin cutaneous melanoma .
Laminins are involved in various cancer development and prognosis.24 25 Increasing evidence suggests that the various laminin isoforms could be useful biomarkers of cancer diagnosis and might be potential therapeutic targets for cancers treatment, such as LAMA5,14 LAMB126 and LAMC1,27 LAMC2 is encoding by Laminin γ2 and has been confirmed as a therapeutic target for cancers. Here we performed a meta-analysis of seven studies to achieve a comprehensive evaluation between higher LAMC2 expression and clinicopathological characteristics in various cancer types. Our results showed that higher LAMC2 expression was significantly associated with LNM, TNM stage and tumour status. However, there was no significant association between LAMC2 expression and age or gender. Simultaneously, we also found that OS/PFS/DSS was higher in patients with low LAMC2 expression. Publication bias analysis demonstrated that no publication bias was observed among the included studies. These results suggested that LAMC2 might be a valuable biomarker for predicting prognosis in patients with cancer. Steyerberg et al provide the prognostic model that can provide effective solving discrimination and predictiveness measures.28 We will plan to investigate this in a later study.
Several kinds of researches have shown that LAMC2 promotes cancer cells proliferation, motility and invasion.29–33 However, the specific mechanisms are not particularly well understood. There is a study indicating that ZNF750 inhibited the migration of oesophageal squamous cancer cells by inhibiting the LAMC2 transactivation.29 In hepatocellular carcinoma (HCC), LAMC2 has been found to be regulated by miR-548c-3p and inhibited the epithelial-mesenchymal transition in HCC.30 In pancreatic cancer cells, LAMC2 promoted Akt-Ser473 phosphorylation and increased expression and cell membrane accumulation of NHE1, promoting cell migration and invasion.31 A study by Wu et al showed that the LAMP3-LAMC2-TNC signal regulated the efficacy of radiation exposure in laryngeal squamous cell carcinoma.32 High-throughput sequencing results showed that miR-338-5 p/3p targets LAMC2 to suppress invasion in salivary adenoid cystic carcinoma cells.33 LAMC2 was found to promote tumour progression by EGFR signalling.34 35 The latest research showed that overexpression of LAMC2 enhanced pancreatic ductal adenocarcinoma metastasis and tumourigenesis through the EGFR/ERK1/2/AKT/mTOR signalling pathway.11 These findings suggested that LAMC2 might play as an oncogene and predict prognosis in patients with cancer.
Recent researches have also investigated LAMC2 as a valuable biomarker of cancer diagnosis.36 37 Due to a limitation of the small sample size, we explored the expression of LAMC2 in various cancer types using (The Cancer Genome Atlas) TCGA database. The results showed that LAMC2 was upregulated in tumours and might be used as a biomarker for a variety of tumour types. Moreover, we explored the survival analysis from the TCGA database. The results demonstrated that higher LAMC2 expression was associated with poor OS in 9502 patients. We also explored the prognostic role of LAMC2 in different types of cancer. LAMC2 expression was significantly associated with OS in LUAD, MESO, SKCM, HNSC and LGG, but not in LUSC. This deserves further investigation.
Some potential limitations of our study should be noted. First, only seven articles were included in our meta-analysis, the limited number of studies might influence the reliability of the results. Of the seven included studies, five were from China and two were from Japan. So, our results may only be applicable to the Asian population. Although we determined data from the TCGA database, future studies from non-Asian populations are needed to confirm our findings. Second, there was no consensus on a cut-off value for higher LAMC2 expression. Third, in some researches, the data for HR and 95% CI value was not provided. Although we tried our best to extract the HR and 95% CI value from the Kaplan-Meier curve, some errors are inevitable. Fourth, the numbers of patients and tumour types included in this meta-analysis were still limited. So, our results may exaggerate the prognostic value of LAMC2.
In conclusion, LAMC2 may be a valuable biomarker for cancer diagnosis, and upregulation of LAMC2 is associated with a poor prognosis in patients with cancer. And increased LAMC2 expression is significantly associated with bad tumour status, TNM stages and LNM. For future clinical applications, more high-quality studies with large sample sizes are needed to confirm the role of LAMC2 in various cancers and regions.
We sincerely thank Dr. Yang Wu for her support in this study.
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Contributors TF and ZY designed the study; TF, ZY and JX searched the literature and extracted data; ZY and TF analysed data; ZY prepared the figures; ZY, J-XL and ZG wrote the manuscript. All authors gave the final approval for the paper to be published. ZY and TF act as guarantors.
Funding This study was supported by the Chongqing Science and Health Joint Project (2021MSXM108).

redpajama_set_name: RedPajamaCommonCrawl


text:
Get Dreaming with NiGHTS! (Sega Saturn, PS3, 360)
Hidden treasures are released and forgotten in every generation. With the plethora of big titles from the Sega Saturn, Playstation and Nintendo 64 era, it was easy to miss some of the great games that were released exclusively on each console. This week, I take a look back through the blue glasses to the heyday of Sega.
The mysterious and energetic NiGHTS
The Sega Saturn was marred with a string of failures for Sega in the early to mid-nineties. The Mega/Sega CD released shortly before the 32X, which sparked debates between Sega America and Sega Japan. The string of hardware releases which attached onto the lucrative MegaDrive/Genesis confused the marketplace. This set the tone of general apprehension for the next big Sega thing. Cue the Sega Saturn. At the time, it was reportedly difficult to program, and there was dwindling third party support. However, hopes were held high in the generation of Sega fans who grew up with the little blue hedgehog, Sonic. What we wanted, as fans, was a Sonic game in full 3D glory, taking advantage of the extra memory and extra blast processing. Screen shots were leaked to the media of a game which was never meant to be; what was delivered to us from Sonic Team instead was something magnificent, NiGHTS: Into Dreams.
Psychotherapist Carl Gustav Jung hanging out with a pipe in his study
When Yuji Naka, the father of Sonic, sat down and began work on NiGHTS, he reportedly sought inspiration from a very unlikely source, the Swiss psychotherapist Carl Gustav Jung. The effects of this inspiration is not immediately apparent, but this is what NiGHTS is all about: layer upon layer of intriguing gameplay.
NiGHTS starts with the player taking control of a child, either boy or girl with different levels for each, and through an unfortunate event you enter a dream world inhabited by unearthly and colourful creatures along with the main protagonist who you control, the mysterious NiGHTS. Essentially, in gameplay terms, you fly around as NiGHTS collecting blue Chips and taking them back to floating 'Ideya Captures'. Collecting 20 blue Chips then releases the Ideya for the different course on each level, which you then have to return to the home area before continuing onto the next course. Sounds simple? Well yes it is, and this is the beauty of NiGHTS. You can breeze through the game doing the standard required pass mark before getting to the bosses, many resembling beings that have swallowed a large beach ball. But there is much more to discover.
One of the many nightopian residents of the dream world
Also inhabiting the dream world is the nightopians, little creatures that you can hatch from eggs, breed and push into fallen enemies. The artificial intelligence of these creatures and the side game is not as complex as the Chao to feature in future Sonic Team titles; however, it is mindful to remember that this was created in 1996, a year when saved games was just in its infancy. You can easily put in hours caring for your little nightopian compatriots who inhabit each level.
The two different Sega Saturn pads side by side
The other component of NiGHTS not immediately apparent is the point system; the real aim is to collect the Chips as fast as possible then, as the clock counts down, collect as many points as you can by performing strings of combos. This would be near impossible with a standard digital pad which was common at the time, but cue the next phenomenal piece of tech rolled out by Sega… the NiGHTS pad! Oooooh! Ahhhhh! I know it looks a bit like a pancake with buttons mashed on the front, but trust me, it is comfortable and the circular 3D pad allows you to motion NiGHTS in unending loops with relative ease.
Christmas NiGHTS in all its colourful glory!
Shortly after NiGHTS' release, Sega gave out Christmas NiGHTS in a number of different venues. Christmas NiGHTS is the first levels of NiGHTS with a massive Christmas theme thrown over the top of the solid gameplay. The already upbeat music is flittered with Christmas bells, and it is still a favourite of mine to pull out every Christmas and play through.
So all in all, NiGHTS is a wonderful game, but why, I hear you ask, do I start my reviews off with this little gem? Well it's simple: it is available on PS3 and 360 right now! As a bonus, it also comes with Christmas NiGHTS! If you're still reading this while you've booted up your system to download the game, I can confidently say that the game will change your life. Go on, get dreaming!
So that we are able to better understand our viewers' perspective and give you more of what you want and less of what you don't, please leave a comment (positive or negative). Care to offer another perspective on something?
Published by Benn Banasik
Husband, Dad, Retro Gamer. PhD candidate at @Sydney_Uni. Former #Wollondilly Mayor.	View all posts by Benn Banasik
Gaming, Reviews
Benn Banasik, game, Games, NiGHTS, NiGHTS Into Dreams, PS3, review, Sega, sega saturn, Sonic, Sonic Team, video game, video games, xbox 360
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← What the…? That's all you can do?
An early goal! – Oh crud →
Ok, so that was not all…
Veröffentlicht am 5. November 2007 | Kommentare deaktiviert für Ok, so that was not all…
After the most disappointing defeat against Babelsberg , Magdeburg had the misfortune to travel to Rot-Weiß Erfurt, one of this season's top teams. Erfurt had the possibility of climbing to the second spot in the table, they only had to win the match. And that shouldn't be a problem, judging by the results of both teams so far. Magdeburg had only managed to produce 13 goals in 14 matches, while conceding 14, Erfurt by contrast had scored 31 times, among their games such memorable encounters as the 6-3 home victory against Ahlen – they had been down 0-2 after twelve minutes.
Magdeburg could not draw any hope from their own performances, especially not from the past two league matches. But there was still a silver lining, as Erfurt were missing no less than three key players: Midfielder Schnetzler had been suspended after picking up his 5th yellow card, forward Kumbela had been banned for a week and two cup matches after headbutting an opposition player in Erfurt's cup match mid-week. Last but not least, Brazilian midfielder Thiago Rockenbach da Silva was out with an injury. Still, Erfurt were favorites to win the match, but against my better judgment I took it upon myself to undertake the 140-mile trip to the capital of Thuringia.
Upon arriving at Erfurt's Steigerwaldstadion, two things immediately caught my attention. First, the presence of low-alcoholic beer proved the police considered the match one of medium risk, and second that the sales personnel was protected by a metal fence from the visiting fans, so you had to grab your beer or Thüringer Würstchen through the fence. I haven't seen that before in any stadium. Makes you feel thoroughly welcome.
Anyway, the match started and Magdeburg achieved something unheard of in this season: Dominance. During the first half, Magdeburg didn't play any fancy football, but they still managed to put Erfurt under so much pressure that the hosts only had two shots on goal in the first 45 minutes.
Magdeburg took the lead when Grundmann put a header off a Gerster cross into the goal. Unfortunately, in all other instances when Magdeburg produced opportunities, there was always an Erfurt player on hand to clear the ball, scratch it off the goal line or what have you.
And then came the 45th minute, Erfurt were awarded a corner kick and Magdeburg proved unable to put the ball out of their box – Erfurt equalized. Magdeburg's defenders were too hesitant in kicking the ball out and goalie Christian Beer was not quite up to his usual standard of keeping.
With quite some apprehension about what might happen in the second half, the teams went into the halftime break, leaving FC Magdeburg fans wondering what was going on. The apprehension was further amplified when Ivica Jarakovic, vital for Magdeburg's attacking play, was subbed out at half-time. However, Magdeburg continued to work hard, trying to re-take the lead, but this time they were without luck as on their few chances they were denied another goal. Instead, Erfurt took the lead when Magdeburg was again unable to get the ball out of the box. Defensive midfielder Habryka was the unlucky one whose clearance hit Erfurt's Wolf plain in chest – he had no problems scoring from 12 yards.
Things got from bad to worse as Magdeburg were now outplayed, and consequently Erfurt scored again. Two of their players found themselves unmarked in 1. FC Magdeburg's box and Wolf headed in after one of his teammates headed (!) the ball to him – that looked more like a training match. In the end, the deserved penalty after a clumsy challenge by Wejsfelt didn't really matter anymore. Magdeburg were soundly beaten, and deservedly so.
What are the conclusions to be drawn from 15 terrible performances in the season so far, with only one or two half-decent half-times? Naturally, after Magdeburg's third-place finish in the last season, many expected the club to do well in the new season, too, at least it was expected the team would not struggle to clinch the vital top-half finish ( league reform and all that). In reality, it turns out the team was performing somewhat above their abilities in the last season. For the past few games, Magdeburg have shown a certain inaptitude in creating a convincing build-up play and more recently also shown some appalling difficulties in defense (the latter seemed to have been resolved after they had plagued the club at the start of the season). The combination of these two problem areas are of course fatal to 1. FC Magdeburg's goal of qualifying for the new third tier of German football.
These difficulties can be traced to one central issue – Magdeburg lack a playmaker, able of consistently putting in good performances. Kais Manai – he filled out that position in the past season, at least for some time – is out of form, and has apparently also had a falling-out with manager Dirk Heyne. Lindemann is not able to act as playmaker because he often lacks vision and also suffers from some difficulties in passing the ball. Gerster is a different case: while he certainly has vision, he often takes too long to decide what to do with the ball and thus slows down the game. Finally, young talent Deumelandt is not experienced enough to perform at Regionalliga level (yet).
But instead of deciding to take play on the wings (where Magdeburg have some able players), Dirk Heyne apparently has no concept for compensating the lack of a playmaker – and no concept for attacking football at all, it would seem, making it almost impossible for Magdeburg to come back from behind in a game. After yesterday's match, Heyne's statements to the press were evident of this helplessness. He said that while in the first half, most things went according to plan, and then went on to say that things get difficult when a team is two goals behind. While there is no argument here, the crux of the matter is the fact that Magdeburg were left two goals behind from being one goal up. Pit Grundmann's statement made clear that the team themselves have no idea what exactly went wrong – the overall mentality at the club seems to be one of despair and helplessness. As this mentality is apparently shared by Dirk Heyne, I personally do not see another way out of the issue than changing the manager. While Heyne may have achieved much for 1. FC Magdeburg this should not stop the board from drawing a line.
In football, nothing is as irrelevant as yesterday's success.
However, there is one event that might turn things around: Magdeburg must beat Union Berlin in their next home game – and comprehensively so. A display of great and successful attacking football is need, and it must be followed up with an equally good performance at the away game in Essen. But I do not believe this is going to happen, sadly.
FC Rot-Weiß Erfurt: Maczkowiak – Hauswald, Nowak, Holst, Kohlmann – Wolf (79′ Schubert), Cinaz, Stenzel (82′ Peßolat), Brückner – Bunjaku, Jabiri (88′ Ivanov)
1. FC Magdeburg: Beer – Grundmann, Prest, Wejsfelt – F.Müller (79′ Probst), Habryka (65′ Tornieporth), A.Müller, Gerster, Neumann – Lindemann, Jarakovic (46′ von der Weth)
27′ Grundmann 0-1
45′ Cinaz 1-1
61′ Wolf 2-1
75′ Bunjaku (pen) 4-1
Dieser Beitrag wurde unter Fußballerisches abgelegt und mit 2007-08, Defeat, Erfurt, Idiocy verschlagwortet. Setze ein Lesezeichen auf den Permalink.


I've been invited to work with a local group for the next 6-weeks as part of a transformation programme, to promote healthy lifestyles in our community as well as raise funds for the local secondary school – Bush Post-Primary in the Cooley Peninsula.
It's a great local programme (Operation Bush4mation) which will follow the national TV programme Operation Transformation. There are many activities lined up, at all times of the day and night, with fantastic trainers in pilates, yoga, boxercise, circuit training, trail running as well as options to use the state of the art running track for walking, jogging and running. The aim is to get people off the couch, think more about what they are eating and get the year off to a great start.
So far we have at least 100 people signed up to participate and Monday 13th January is kick-off.
I was asked to write a piece for making positive dietary changes and have included it here also for your information.
At the start of every New Year, there is always so much talk about resolutions and making dietary changes. While it is a great opportunity to jump start your plans towards good health, for many, the resolutions don't make it past the first week!
Part of the reason for this is that the goals set are too general and vague i.e. I'm going to get fit in 2014 or I'm going to eat healthier in 2014.
Another way to approach making changes is to set SMART goals – Specific, Measurable, Achievable, Realistic and Time bound. None of the goals mentioned above meet these criteria. If you don't pick a realistic goal, you are setting yourself up for a fall before you've even started. Is it any wonder people slip off the wagon after the first day or the first week?
An example of a SMART Goal might be – I am going to eat breakfast every morning before work for the next 3 months. You can have several, smaller goals like this and if achieved, together they may contribute to a broader goal such as weight loss.
This may seem strange coming from a Dietitian but this is my mantra. Going on a "Diet" brings with it feelings of restriction, denial, guilt and the inevitable falling off the wagon when you can't live with the changes on an ongoing basis.
We need to move away from this extreme "all or nothing" approach to eating, and learn to embrace making changes that we can live with and that are sustainable. Food should be enjoyed, not feared. I saw someone joke on twitter the other day about why we never hear about the 7:0 diet – where you strive for a healthy diet 7 days a week.
TOP Tips to Help You Achieve a Healthy Weight.
Ultimately, to lose weight you need to reduce your energy intake so that you are eating less calories than your body expends. The following are a series of ideas to help you with that.
Think about how amazing the human body is and how important it is for your health to nourish it well. You will feel so much better when you are making better dietary choices and you deserve this level of care.
I would highly recommend sitting down every weekend and planning your weekly menu. Once you have decided what you plan to cook Monday to Friday, you can do your shopping in a planned way. This will save you time during the week and will prevent you standing at the cooker at 6 o'clock in the evening, wondering what will I cook tonight, only to find you don't have half the ingredients in stock. This is where things go wrong and you reach for less healthy options.
Eat a protein-rich breakfast – porridge made on milk; stewed or fresh fruit with yogurt, poached eggs on toast, baked beans on toast etc. A protein rich breakfast has been shown to help control appetite.
Some studies have shown that breakfast eaters are less overweight than breakfast skippers, although more evidence is needed on the broader topic of meal frequency and meal skipping and whether this affects weight loss.
One recent study showed that people on a restricted calorie intake who eat their largest daily meal at breakfast are more likely to lose weight and waist line circumference than those who eat their largest meal at dinner time.
Portion control is one of the keys to weight loss. To get an idea of what a portion is, weigh some standard portions out on a kitchen scales. Do you have any idea what 40g breakfast cereal or 50g uncooked rice? The chances are the weighed out portions looks a lot smaller in reality than you expected! I'm not suggesting that you do this all the time but as an experiment it's worth doing and may make you think twice when dishing out your meals.
The Food Safety Authority Healthy Eating and Active Living Booklet provides some very practical information on what constitutes a portion size of the different food groups and how this varies depending on whether you are trying to lose weight or not. They describe portions in household measures (i.e. cups versus grams). If you are using this resource, measure the suggested portion sizes, to familiarise yourself with appropriate serving sizes.
Big serving plates = Big Servings. Switching from a 12 inch to a 10 plate for your main meal – would result in 22% less calories being served. If your plates at home are very big, make the switch to a smaller plate.
Also, make sure to portion your plate in the healthiest way. Fill half your plate with vegetables and/or salad and then the other half of your plate should be divided between carbohydrate and protein.
This is very different to how most Irish people dish out their meals. We tend to fill the plate with rice or pasta and then pile the protein/vegetables on top which results in much bigger portions of rice/pasta/potatoes than recommended.
Fruit and vegetables provide fibre along with a range of vitamins (A,B, C, E and K) and minerals (potassium, magnesium and some iron). These foods are low in calories and contain no fat (Avocado and olives are the only exception). This is one food group where MORE is definitely BETTER. These foods can be used in place of more high calorie, highly processed snack foods to improve the overall quality of your diet and help reduce calories.
Many of the foods we eat have been processed in some way but try to make a habit of eating foods that contain minimal added ingredients and that are processed as little as possible. Food should have a place (know its source – locally produced where possible), a face (farmer) and great taste.
Also, by eating whole-grains instead of more refined foods (i.e. wholegrain bread versus white bread), you will have a higher fibre intake. A high-fibre intake makes you feel fuller for longer and can help with weight loss.
Eat mindfully – Be more aware of each bite I take and enjoy each bite.
Mindful eating very much ties in with the idea of sitting down for meals at the dinner table without the distraction of TV. This is something which seems to be happening less and less as TV dinners become increasingly popular. My advice, switch off the TV and insist that the family sit down together for Dinner in the evening and use the opportunity to catch up on everyone's day.
Other aspects of Mindful eating include, avoiding eating out of a packet – make sure to put your food out onto a plate and sit down and enjoy it and know what you are eating.
Keeping a food diary can be very helpful for some people to keep track of what they are eating and identify when they are most likely to go off track with less healthy options.
Denying yourself the foods you love, makes you crave them more and you are more likely to binge eat when the opportunity presents itself. Labelling foods as either good or bad, makes you fear the so-called 'bad' foods. I prefer the concept of good and bad diets versus good and bad foods.
For a long-term healthy eating plan that is sustainable, aim to eat well most of the time of the time and build into your plan some small treats. This way, you can look forward to them without over-doing it and you don't feel deprived. If chocolate is your thing you should avoid keeping chocolate in the house and when treating yourself, choose a kid-size bar.
Don't Underestimate the Importance of Sleep (thought you'd like this one)!
One study showed that sleep deprived women ate 15% more calories and 39% more dietary fat than those who got more sleep.
Lack of sleep may inhibit your ability to lose weight. Another study showed sleep deprived people lost 55% less body fat and lost 60% more lean body mass.
It's Not about Being Perfect All the Time.
A long-term healthy weight loss program is not about being perfect all the time. It's about balancing the not so good days with better ones. If you have a bad day, it's not the end of the road. Dust yourself down, re-examine your SMART goals and start again.


Hello Zee Zee..Can you possibly help?? I was promised my gold back!! Also, I never rec'd my prize-award for the contest in which I named the new map!!! I NEVER GOT THE CREDIT NOR THE PRIZE!?! IVE TRIED EVERYTHING.PLEASE HELP.
I heard the tommy gun is your favorite gun!
Wow that's nice. You will keep that up.
I find it better to report hackers and cheaters on the forums than the Discord, because Discord messages cycle quickly and can disappear forever. I feel that the forums are more permanent and you are able to sustain and keep track of subjects better.
Get a ping of 20ms, then see the difference. You will be a better player all round. Ping makes all the difference.
@EXTINCT1ON : Wow. He is insane player tho.
How bad can it be ? Worse than 220ms, welp! In that case, stick to asia. If not, get to EU.
LordAlmighty and Zee Girl like this.
MOdS ISN'T AROUND...THAT'S WHY HACKERS ARE EVERYWHERE. THEY SELECTED YOUTUBERS TO BE A MOD INSTEAD OF ACTIVE PLAYERS.
LordAlmighty, CarryMinatiii and Armaghan like this.
Good luck for you who have signed up to be a moderator!
KingPrevail and FabulousMrToad like this.
PepeLePierre420, Armaghan and EXTINCT1ON like this.
Armaghan and EXTINCT1ON like this.
This game needs more protections!
Lucas has privately commented on the issue and has said he is unable to find a solution to that problem.
I think BF needs protection like modern combat 5 , how about that ?
Battlefield 4 has a system called 'FairFight', which detects cheaters by monitoring how many kills they get per minute, whether they fire too many bullets too quickly and other factors.
Two accounts has been unbanned today. Well, it's my friends' account but that what makes me really happy!
FabulousMrToad and EXTINCT1ON like this.
Hackers ... Dont you feel what the others felt? We are fair played and you dont. Is it hard to play fair?? Come on. Hacks is for noobs.
XV13000Fowlie and EXTINCT1ON like this.
A good gamer is an honest one and people need to just play by the rules and have fun.


text:
Leslie Armstrong
Girl Intrepid
A New York Story of Privilege and Perseverance
It is not easy to be stylish and moving and sad and funny all at once, but Lale Armstrong does it all in Girl Intrepid.
Betty Rollin, former NBC News Correspondent, author of First You Cry
Lale Armstrong tells a juicy pre-feminist rite-of-passage tale, but this book is also a sharp-tongued pathology of privilege, its cluelessness and its cruelty, and she writes about all of it with wit — breezy, ironic, defiant.
Stephen Wadsworth, Marivaux: Three Plays; Moliere: Don Juan; co-author with Leonard Bernstein of A Quiet Place
Praise for Girl Intrepid
It will be shelved under 'Autobiography' or 'Memoirs,' but it is also a masterful work of anthropology, a compelling tale of a stubborn female individual coming of age not in Samoa but in upper-class America just before women's rights kicked in. Laced with a subtle under-wit and sometimes alarming candor, Girl Intrepid will captivate you.
Gail Godwin, A Mother and Two Daughters and A Southern Family
Reads almost like an update of Edith Wharton's novel House of Mirth about the shadow side of New York high society during the Edwardian era. Armstrong's vivid account of growing up in that world – and then growing away from it as an adult — serves as a sobering reminder that wealth doesn't solve (and perhaps complicates) the nagging human need to forge one's own identity. Armstrong's torturous journey toward this goal makes for fascinating reading.
Lisa Alther, Kinflicks and Blood Feud: The Hatfields and the McCoys
Lale Armstrong has a powerful gift for narrative, and true to her calling as a designer, every detail is perfect. She sees the New York social whirl with the perceptiveness of Edith Wharton; but she brings a very modern exuberance as she tells the story of a busy coming- of-age, with sidelong glances at the CIA, NASA, the civil rights movement and some of the world 's most exotic locales. This is a wonderful joy ride of a book.
Ted Widmer,Young America: The Flowering of Democracy in New York City and Disunion: A History of the Civil War
What an adventure! Architect Lale Armstrong takes us on an incredible ride—in turns joyful, poignant and tragic—through a life that gets to the heart of the generation that came of age just after World War Two.
Ross Klavan, Thump Gun Hitched and Schmuck
Read the Reviews
Copyright © 2023 Leslie Armstrong. All rights reserved.


text:
Noisy Massachusetts Wind Turbine Shut Down
The state of Massachusetts, which earlier this year released an independent study that largely dismissed claims that living near wind farms can cause a range of devastating health effects, is now cracking down on noisy turbines.
In March, the state's Department of Environmental Protection (MassDEP) conducted tests of a couple of turbines at the Falmouth, Mass., waste treatment plant, where neighbors had complained of excessive noise. In a new report [PDF], that state said the tests revealed that sound levels from one of two Vestas V82 1.65-megawatt (MW) turbines "exceed the 10 dBA threshold that MassDEP defines as unacceptable sound at one of the sampling sites under both high and low wind conditions."
image via Vestas
So the department recommended to Falmouth that the turbine be shut down while it conducts further studies – and that the second turbine be switched off at night, as well.
According to the state, neighbors have complained about noise problems since the town installed the first turbine more than two years ago as part of a MassDEP energy management pilot program to reduce the energy use and greenhouse gas emissions of drinking water and wastewater treatment facilities.
In the summer of 2010 the town commission a study [PDF] that found that sound levels around Wind #1 approached but did not violate state standards and predicted that a second turbine, then under construction, would lead to "no violations at any measurement positions." But measuring sound is a complex matter, and the city took issue with the study done by the consultants. Meanwhile, residents were telling stories of devastating health consequences from the noise.
Eventually, the state moved to conduct further testing. The result of that testing — a decision to curtail wind power production to look further into the noise issue — was a bit surprising, since Massachusetts Gov. Deval Patrick and his administration are big backers of wind power. In fact, just a few weeks ago, the governor attended the opening of a 10-turbine, 15-MW wind power plant in the Berkshires.
The state's environmental protection commissioner, Kenneth Kimmell, told the Boston Globe the new Falmouth noise report "demonstrates that Massachusetts DEP calls balls and strikes in an impartial way and holds wind turbines to the same standards as we apply to other industries." That said, Kimmell said other turbines operate in the state in residential areas with little complaint.
One difference between the Falmouth case and others could be the type of turbine used, according to the Cape Cod Times. The paper said opponents of a new set of turbines in Fairhaven, Mass., were cheered by the state's action on Falmouth, but the Fairhaven wind developer said its "pitch-regulated" turbines are quieter than the "stall-regulated" Falmouth Wind #1.
According to information on the website of the Texas wind developer Horizon Wind Energy, pitch-control and stall-control are the two basic approaches used to control a wind turbine in high speed winds. "In pitch-controlled turbines, an anemometer mounted atop the nacelle constantly checks the wind speed and sends signals to a pitch actuator, adjusting the angle of the blades to capture the energy from the wind most efficiently," according to Horizon. "On a stall-regulated wind turbine, the blades are locked in place and do not adjust during operation. Instead the blades are designed and shaped to increasingly "stall" the blade's angle of attack with the wind to both maximize power output and protect the turbine from excessive wind speeds."
Whatever the case, the turbines in Fairhaven, although new, are drawing plenty of complaints — 27 in one month, according to the Cape Cod Times.
Meanwhile, in Falmouth, some residents claim to be victims of "wind turbine syndrome." But the state-convened panel of medical and environmental health experts that reported in January found little or no evidence to back up claims that low-frequency sounds from turbines harm the vestibular system, or that turbine noise brings psychological distress or mental health problems, or that there is an association between turbine exposure and pain and stiffness, diabetes, high blood pressure, tinnitus, hearing impairment, cardiovascular disease and headache or migraine.


How do these people do it? Every year in New York City, Nathan's Hot Dogs does their hot dog eating contest on the 4th of July. And for 2018, Joey Chestnut ran away with a huge win! He ate 74 hot dogs and that is also a world record. Watch Joey Chestnut dominate the contest below!


Having your very own gaming business could grow more than you would expect it. Entrepreneurs at the world have signed up for merchant accounts assist them bring more customers into their client base. There are many benefits offered by means of different methods of payment to customers in helping your business grow.
There are many attributes of getting a merchant be the reason for your online gaming merchant account bad credit business. A payment processor will an individual accept credit cards numerous kinds from your shoppers. You will also be able to simply accept payments from American Express, Discover, Visa and MasterCard, expanding your business throughout the globe.
With this sort of set up, your business will be gaining more than double of your regular profits compared when you've got are only serving people around your local area. With the multitude of people in which hooked up upon the internet everyday, rather a lot of businesses have been using the internet as a mode of making more customers.
A gaming or casino merchant account can increase revenue dramatically. Not you alone will be prepared to benefit from such a type of transaction but also will your participants. They can enjoy the ease wherein they could a purchase with little effort when years before.
However, getting one for high risk businesses can be rather difficult, but a person have have found make certain that you think is reliable, you'll be amazed that merely simple process will be made and normally requires you about quick moment to complete the transaction. Once it has been approved, you will be receiving a voice message and instruction regarding how to put into operation your new merchant account and also just how to incorporate your overall business workings.


Are you trying to open a webm file? Find here the right software which will enable you to view, open or edit Matroska Webm Video File type.
A WEBM is a high-quality compressed video file. The video is compressed using VP8 technology whilst the audio compression is done using Ogg Vorbis.
This file format is often used for online videos using HTML5.


text:
How To Raise Mermaids Hentai Manga
How To Raise Mermaids Hentai Manga Among the many kinds of anime, hentai is the most popular sub-genre. It is a sort of adult anime that features both male and female characters. It might seem similar to human pornography, it has a different visual design, and the relationship between the consumers and the characters in the anime are not the exact same.
'Hentai ' is an abbreviation for hentai seiyoku (Japanese for "sexual perversion "), and it is a term utilized for manga, anime, computer game, and other types of popular entertainment. It can describe lots of kinds of pornographic works, but generally it 's defined as being sexually specific and uncensored.
During the Edo Period (1603-1868), shoguns reduced the production of shunga, Japanese sensual art. Till the late 19th century, shunga had actually been mainly confined to a couple of books and journals. These were later augmented by pornographic pictures and the development of comics.
What Is The Best Tentacle Hentai
How To Play Hentai Games On Mac
Why Is Hentai Haven A Org Site
Where To Buy Old Hentai Dvids
A Memorable Trip To The Mall E Hentai
Does Tubi Have Hentai
A Bimbo's Journey Bot Comic Hentai
A 500 Expansion Rate Hentai
A Dapper Man Steampunk Mustache Hentai
A Hentai With Reverse Pare
Prior to then, the most popular hentai anime was produced by Japanese cartoonists. Among them was The Dream of the Fisherman 's Wife, a story about a woman who is promoted by 2 octopuses. How To Raise Mermaids Hentai Manga
Another important figure was Toshio Maeda, who was called the "god of tentacle hentai. " His work included beasts that had various genitalia. He sought to get past censorship laws relating to sexual intercourse.
The history of hentai is long and differed. While the term originated in Japan, the Western World experienced a sexual transformation. The increase of modern-day worths made sex beyond traditional marriage and sexual relationships appropriate.
The term 'hentai ' is often referred to as 'perverted ', 'weird ', and 'abnormal '. In truth, hentai works have more reasonable themes than their cartoon-cute versions. They also portray characters more realistically than those in Tezuka 's manga.
Today, hentai has a wide audience. Adult styles have actually belonged of manga considering that the 1940s. During the '50s and '60s, stories of male homosexuality and cross-dressing were the most common preoccupations in magazines.
The hentai industry began to blow up after the war. In 1928, Gurotesuku was established, and it focused on pseudo-academic sexual material. Other publications of this duration consisted of Fuuzoku Kagaku, Kitan Kurabu, Ningen Tankyuu, and Ura Mado.
During the 1970s, Hentaigaku Nyuumon was published by Akiyama Masami. The book was filled with guidance pages penned by supposed sexual professionals.
In spite of the visual differences between hentai and human pornography, there are still concerns about how these 2 types of sexually exciting media affect people. This is especially true in the case of hentai. Its use in video games and anime may influence individuals 's beliefs about romance and sexual arousal. Hentai customers may have different romantic understandings than other types of porn customers. How To Raise Mermaids Hentai Manga
To explore this question, a research study was conducted. The results showed that hentai customers ranked anime characters more attractive than non-porn customers, but not differently than other types of pornography customers. How To Raise Mermaids Hentai Manga
Aside from the sex-related steps, the most significant findings were that male hentai consumers were more inspired by assisting in sexual satisfaction than human pornography customers. Particularly, male hentai customers were more likely to be thinking about avoiding negative feelings, helping with sexual satisfaction, and pleasing sexual interest. Hentai consumers were more most likely than other types of pornography consumers to wish for a real-world romantic relationship.
The study also discovered that male hentai customers scored higher on measures of beauty, desire for a romantic relationship, and accessory anxiety than male human pornography consumers. When comparing the 2 types of pornography consumed by means of desktop computer, this is particularly true.
A few other findings were likewise noteworthy. For example, hentai customers tended to score considerably higher on the Spearman 's rho matrix for procedures of attraction. While hentai intake did not modify the score on these procedures for other kinds of pornography consumers, it does appear to impact ball games on the rho matrix for hentai customers.
In addition, hentai consumers rated human images more appealing than hentai consumers rated anime images, but just if the image 's background was standardized. A future research study should look at the impact of the color pattern of the image on its attractiveness rankings. Lastly, future studies must consist of more standardized background colors and pose-related variables, and a wider range of images.
In general, this research study is the first to investigate how hentai and human pornography are perceived differently, and to what degree. Whether or not these distinctions are the outcome of a real misconception or just a result of the kind of pornography saw, a more thorough evaluation of the distinctions and resemblances is necessary.
Relationships between hentai consumers and anime characters
Whether or not you consume hentai, you may have seen that lots of anime characters have a strong appeal to fans. These characters may even have a greater influence on hentai consumption than other kinds of adult media characters.
In a current study, scientists took a look at how hentai customers and other kinds of porn consumers perceive anime characters. The findings of the research study showed that hentai fans are most likely to discover an anime character appealing than a similar picture of a real person. It also showed that hentai customers are more likely to wish to get associated with a romantic relationship with a character from an anime than a similar person. This might be a function of a higher desire for the sexually suggestive imagery of anime characters compared to a real human.
The study consisted of questions about anime genres, soundtracks, quality of material, and other anime-related subjects. The results were examined utilizing SPSS version 25. How To Raise Mermaids Hentai Manga
The study found that hentai fans had a higher rating on an image score job, which determined the quality of the photo and its features. However, the image was not standardized, and the background colors were not controlled for. This suggests that the same background color may have had a more dramatic impact on one participant 's score than another.
The survey also discovered that hentai consumers are more likely to want to have a romantic relationship with a character from anime than a similar human. In addition, male hentai customers were most likely to have a positive reaction to the image, in addition to an interest in sexual satisfaction.
The outcomes of this research study show that the image score job is a clever method to measure a hentai consumer 's desire to have a romantic relationship with an anime character. However, the research study was unable to identify if these elements are affected by the type of porn they take in. This suggests that future studies require to distinguish between hentai and other kinds of pornography.
Throughout the 1980s, a Japanese sub-genre of manga was born. It was a kind of slang explaining stories about girls and their sexual encounters. It later on ended up being connected with pedophilia in Japan.
This sub-genre has actually developed from its starts to encompass all sorts of categories. Lolicon is a popular anime design in which girls are portrayed in sexual situations. It has gone beyond controversy and has ended up being a part of mainstream culture.
Many individuals have various opinions about lolicon, nevertheless, it is very important to comprehend what it is. It is not the like kid pornography, which is considered profane in some countries.
This type of porn consists of basic drawing designs and incomplete messages. The characters are not genuine kids, but instead represent a hyper-passive state of mind.
Some argue that child pornography need to be criminally prosecuted, but others think it should be constitutionally protected. A brand-new law, the PROTECT Act of 2003, has actually developed a more particular meaning of child pornography. It restricts the circulation of kid pornography, as well as the compilation and transmission of virtual kid pornography over the internet. It also prohibits the transportation of child porn throughout state lines.
This is a questionable concern, but it is not always something that United States law enforcement cares about. In truth, it appears that a number of industry associations associated with anime and manga have actually opposed the brand-new kid porn law.
The Japanese media has actually taken upon the existence of anime in the bedroom of Tsutomu Miyazaki, who was implicated of eliminating four elementary school women in 1989. In response, the press branded him an "otaku killer ".
The lolicon has been banned in some U.S. states, the phenomenon continues to grow. In truth, it is ending up being a huge part of the popular culture of Japan. The appeal of illustrated entertainment amongst young Japanese has sustained the introduction of the lolicon. How To Raise Mermaids Hentai Manga
Another important figure was Toshio Maeda, who was called the "god of tentacle hentai. The term 'hentai ' is typically referred to as 'perverted ', 'creepy ', and 'unusual '. The outcomes indicated that hentai customers rated anime characters more appealing than non-porn customers, however not in a different way than other types of porn consumers.
Aside from the sex-related steps, the most considerable findings were that male hentai customers were more motivated by facilitating sexual satisfaction than human pornography customers. While hentai usage did not modify the rating on these steps for other types of porn consumers, it does appear to impact the ratings on the rho matrix for hentai consumers.


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Q: Is there a way to use different pattern for different packages when using log4j2? I'm using log4j (through slf4j) and I'd like logs from some packages to output filename and line numbers but for others I just need the level and the message. Is there a way to achieve this? Is it possible to specific different layout.ConversionPattern for different classes/packages using the log4j2.properties file?

A: You can use more than one appender of the same type:
Here is an example:
<Appenders>
    <Console name="ConsoleA" target="SYSTEM_OUT">
         <PatternLayout pattern=="%-4r [%t] %-5p %c %x - %m%n" />
    </Console>
    <Console name="ConsoleB" target="SYSTEM_OUT">
         <PatternLayout pattern=="%d{HH:mm:ss.SSS} [%t] %-5level %logger{36} - %msg%n" />
   </Console>
</Appenders>

<Loggers>
   <Logger name="com.foo.BarA" level="trace">
      <AppenderRef ref="ConsoleA"/>
   </Logger>
   <Logger name="com.foo.BarB" level="trace">
     <AppenderRef ref="ConsoleB"/>
   </Logger>
</Loggers>

Read more at Log4J configuration manual

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