If someone were to make a computer model of your home and show all of the entry points that are big enough for spiders to pass through, you would probably be shocked. However, spiders can easily find these holes and will use them to their advantage. Spiders don't view our homes the same way we do and spend a lot more time hanging out on our exterior walls, quite literally. And since they are so small, they can utilize any holes in the exterior of your home to find their way inside, holes you might not have evennoticed.
Spiders also have a mobility that we as humans don't have. They can scale our homes and explore our vulnerable rooflines without the need for a ladder. They can crawl under our decks without having to pull up boards up with a hammer. They can explore every inch of your siding and exploit every gap. So right out of the gate, it is important to understand that it is extremely hard to keep spiders out of our homes. But that doesn't mean that we shouldn't try.
Damaged screens or gaps around screens can grant spiders entry into your home. If you always keep your windows shut, that may be as far as those spiders get. But when carpenter ants, rodents, or other pests capable of chewing holes in the wood of our homes find their way inside, they can create holes that spiders can use to go from your window void into your wall voids.
Doors aren't always as well-sealed as you might think. Some door frames can have tiny gaps that spiders can use to get inside. Spiders may also be able to slip past weather stripping on sliding glass doors or slide underneath doors that don't have door sweeps installed on them.
Before finding their way into our homes, spiders often invade our garages by exploiting gaps around the garage door or by crawling in through the door when it is left open. Once inside the garage, they oftentimes find small holes that have been overlooked as we don't put as much effort into maintaining the interior of our garages as we do with the interior of our homes. If you have overlooked holes in the interior of your garage, be aware that this could allow spiders to take advantage of ceiling and wall voids that connect through to the interior of your home.
Some homes have pipes or conduit that pass through their foundation walls. These can sometimes have gaps around them or chipped mortar that spiders can use to gain entry to our homes.
Tree branches that touch the exterior of a home or hang over the home's roofline provide spiders with quick and easy access to that home's roofline, where there are many tiny gaps they can slip through to gain access to attic spaces.
Over time, chimneys can pull away from the side of homes and create a gap that spiders can use to get inside.
If you seal all of the potential entry points listed above, you will have fewer spiders in your home simply because there are fewer ways for they can get in. However, even after eliminating these common entry points, spiders can still find a way to get inside. So, along with sealing entry points, it is important to reduce the spider populations near your home.
Spiders feed primarily on insects, especially flies. If you have flies buzzing around your exterior trash cans, don't be surprised to find spiders creating webs there as well. To reduce flies and the spiders that feed on them, store your trash in sealed containers and routinely clean those containers.
Flies are also attracted to our homes by exterior lights, which is why you'll often find spider webs around light fixtures. If you keep your lights off at night or replace exterior white lights with yellow lights, you can help resist flying insects and the spiders they attract.
Have you ever noticed a spider web in one of your windows? That is actually a very common place to find them. This is because flies are drawn to the light inside your home. When they fly toward that light, they get caught in the webs that spiders leave on your window panes. Therefore, if you keep your shades drawn at night, you can help reduce the spider populations near your home.
Insects love plants. If you have lots of plant life around the exterior of your home, you can expect to have spiders nearby. Spiders are attracted to the insects that can be found around plants, so everything that you do to reduce the population of plant-eating insects will also help reduce the number of spiders found around your home.
Many insect species are attracted to moisture. If you have shaded areas on your property that get very little sun to dry them out, you can expect to have bugs crawling around in these areas. And, in turn, you can also expect to have hunter spiders crawling around in these areas, searching for insects to feed on. To reduce the moisture levels on your property, trim tree branches to allow the sun to dry the soil in areas that get a lot of shade, fix leaky fixtures, plumbing, and hoses, and unclog any obstructed gutters and make repairs to any gutters that are broken. In addition, if you have a broken downspout that is allowing rainwater to run down your roofline, through your gutter system, and into the soil next to your home, this should be a top priority on your to fix list.
Some spiders don't squeeze in through holes in the exterior of your home, but are actually carried in on a variety of different items. This can happen when you buy a piece of used furniture or pick up a free item off the side of the road. It can even happen when you park your car outside for a while and then pull it into the garage. One of the most common ways spiders hitchhike into our homes is on trees and plants as eggs. If there are spider eggs on a Christmas tree, when it is brought inside the warm temperature of a home can cause all those eggs to hatch and hundreds of spiderlings to emerge. And that's a Christmas present no one wants to receive!
When the temperatures begin to drop in the fall, spiders often enter our homes for the winter. It is important to understand why they do this. They don't invade our homes to escape the dropping temperatures as spiders actually do quite well in the cold. They actually invade our homes to gain access to the insects they like to feed on that take shelter inside our homes during the fall and winter months. Therefore, if you want fewer spiders in your home, it is important to take measures to keep those overwintering insects out.
Even after following all the spider prevention tips listed above, you may still end up with a spider problem. For the easiest and most effective spider control, reach out to us at American Pest! If you'd like help setting up a plan for your home, give us a call today. We'd be happy to help protect your Maryland home from spiders and a variety of other home invaders!


text:
import { Pipe, PipeTransform } from '@angular/core';

@Pipe({
  name: 'metersToMiles'
})
export class MetersToMilesPipe implements PipeTransform {

  transform(value: number): number {
    return isNaN(value)?undefined:value/1609.344;
  }

}

redpajama_set_name: RedPajamaGithub


text:
Multi-cloud is the only way to meet data demands – Openstack Foundation
26 October 2016 @ 11:41
Speaking at the Openstack Summit, the Openstack Foundation's Executive Director Jonathan Bryce threw another buzzword into the mix for us to consider; multi-cloud.
While the technology industry is seemingly awash with buzzwords and the latest trends, the Openstack Foundation has pinned its future on the development of a multi-cloud culture. While it may sound similar to a hybrid proposition, multi-cloud not only takes into account the different topologies, but also different vendor platforms, all working seamlessly in a perfect world.
"The future is absolutely going to be multi-cloud," said Bryce. "Users don't really care about what the technology is or where it came from, they just want it to work for them.
"When you look at the scale and when you look at the variety of demands on the industry, the future has to be multi-cloud."
Scale is something the technology industry is used to, but we're very rapidly entering into an age where a tsunami of information and data is set to swallow us. CERN's Tim Bell estimated civilization had produced 5,000 petabytes of data since the dawn of time, but this number is about to be dwarfed. In 2010, 5,000 petabytes of data was produced every two days, and this number is only getting bigger.
Cambridge University was another to showcase its talents at the Summit, specifically in the form of its Square Kilometre Array (SKA) project. The SKA is a new radio telescope project, currently in the design study phase, which will have sensitivity 100 times greater than the most sensitive radio telescopes of the present generation, and an ability to survey the sky up to 1 million times faster. The project will take place over two sites in South Africa and Australia.
Once the project is launched in the near future, it will collect 5,000 petabytes a day, and in ten years, this number will increase to 100,000 petabytes per day. This is a single project, from a single organization. Considering how other organizations will increase their appetite for data, the growth is almost unimaginable.
For Bryce, only a multi-cloud environment will meet this demand. It's not a single network, but a software-defined, distributed network, which does not limit the customer to a single vendor or platform.
This is not however limited to those nasty corporate giants which the Openstack Foundation seem to be very happy to smear in an effort to promote its own platform, as Bryce admits Openstack is not the ultimate answer to every challenge. There will be requirements for engineers to look into Kubernetes or OPNFV or the Cloud Foundry, but this is the approach which will define the multi-cloud culture and the positive sum gain.
So forget about everything else, multi-cloud is where it's at.
Tags: Multi-Cloud, OpenStack, Openstack Foundation
Telstra: COVID-19 is forcing companies to become cloud-first
Vodafone bags Big Blue as $550 million partner
Nuage updates SD-WAN proposition to tackle multi-cloud complexities
Data Transfer Project could cut AWS cloud dominance – Equinix

redpajama_set_name: RedPajamaCommonCrawl


text:
package com.Xiamu.android.criminalintent;

import java.io.FileOutputStream;
import java.io.IOException;
import java.util.List;
import java.util.UUID;

import android.annotation.TargetApi;
import android.app.Activity;
import android.content.Context;
import android.content.Intent;
import android.content.res.Configuration;
import android.hardware.Camera;
import android.hardware.Camera.Size;
import android.os.Build;
import android.os.Bundle;
import android.support.v4.app.Fragment;
import android.util.Log;
import android.view.LayoutInflater;
import android.view.OrientationEventListener;
import android.view.SurfaceHolder;
import android.view.SurfaceView;
import android.view.View;
import android.view.View.OnClickListener;
import android.view.ViewGroup;
import android.widget.Button;

public class CrimeCameraFragment extends Fragment {

	private static final String TAG = "CrimeCameraFragment";

	public static final String EXTRA_PHOTO_FILENAME =
			"com.xiamu.android.CrimeCameraFragment.photo_filename";
	public static final String EXTRA_PHOTO_ORIENTATION =
			"com.xiamu.android.CrimeCameraFragment.photo_orientatiion";
	private View mProgressContainer;

	private Camera mCamera;
	private SurfaceView mSurfaceView;
	private int orientation;
	//½«ÁбíÖеÄÔ¤ÀÀ³ß´çÓë´«ÈësufaceChanged()·½·¨µÄsurfaceµÄ¿íºÍ¸ß½øÐУ¬ÕÒµ½×î¼ÑµÄ´óС
	private Size getBestSupportedSize(List<Size> sizes, int width, int height){
		Size bestSize = sizes.get(0);
		int largestArea = bestSize.width * bestSize.height;
		for(Size s : sizes){
			int area = s.width * s.height;
			if(area > largestArea){
				bestSize = s;
				largestArea = area;
			}
		}
		return bestSize;
	}
	//ÔÚÏà»ú²¶»ñͼÏñʱ±»µ÷Óã¬ÏÔʾ½Ó¿ÚÏÔʾÌõ
	private Camera.ShutterCallback mShutterCallback = new Camera.ShutterCallback() {

		@Override
		public void onShutter() {
			// TODO Auto-generated method stub
			mProgressContainer.setVisibility(View.VISIBLE);

		}
	};
	//ÔÚԭ'ͼÏñÊý¾Ý¿ÉÓÃʱ±»
	private Camera.PictureCallback mJeCallback = new Camera.PictureCallback() {

		@Override
		public void onPictureTaken(byte[] data, Camera camera) {
			// TODO Auto-generated method stub
			//´´½¨ÎļþÃû                     È«¾ÖΨһ±êʶ·û£¬µÄÒ»¸ö×Ô¶¯Éú³ÉÖ÷¼üµÄ·½·¨
			String filename = UUID.randomUUID().toString() + ".jpg";
			//±£´æÎļþ
			FileOutputStream os =null;
			boolean success = true;

			try {
				os = getActivity().openFileOutput(filename, Context.MODE_PRIVATE);
				os.write(data);
			} catch (Exception e) {
				// TODO: handle exception
				success = false;
			}finally{
				try {
					if(os != null)
						os.close();
				} catch (Exception e) {
					// TODO: handle exception
					Log.i(TAG, "Error closing file" + filename, e);
					success = false;
				}
			}
					//Èç¹ûÊý¾Ý±£´æ³É¹¦£¬Ôò·µ»ØÊý¾Ý
					if(success){
						Log.i(TAG, "JPEG saved at" + filename);
						MyOrientationDector cameraOrientation = new MyOrientationDector(getActivity());

						int orientation = cameraOrientation.getOrientation();
						Log.d("MyOrientationDetector","µ±Ç°µÄ´«¸ÐÆ÷·½ÏòΪ"+ getResources().getConfiguration().orientation);
						Intent i = new Intent();
						i.putExtra(EXTRA_PHOTO_FILENAME, filename);
						i.putExtra(EXTRA_PHOTO_ORIENTATION, getActivity().
								getResources().getConfiguration().orientation);

						getActivity().setResult(Activity.RESULT_OK,i);
					}else{
						getActivity().setResult(Activity.RESULT_CANCELED);
					}
				getActivity().finish();
		}
	};
	@SuppressWarnings("deprecation")
	@Override
	public View onCreateView(LayoutInflater inflater, ViewGroup container,
			Bundle savedInstanceState) {
		// TODO Auto-generated method stub
		View v = inflater.inflate(R.layout.fragment_crime_camera, container, false);
		mProgressContainer = v.findViewById(R.id.crime_camera_progressContainer);
		//ÉèÖýø¶ÈÌõ²»¿É¼û״̬,Ö»ÊDZä͸Ã÷ÁË
		mProgressContainer.setVisibility(View.INVISIBLE);

		Button takePictureButton = (Button) v.findViewById(R.id.crime_camera_takePictureButton);
		takePictureButton.setOnClickListener(new OnClickListener() {

			@Override
			public void onClick(View v) {
				// TODO Auto-generated method stub
				//activityÍ˳öÕ»£¬µ«²»Ïú»Ù¡£·µ»Øµ½ÁбíÃ÷ϸ½çÃæ
				if(mCamera != null){
					mCamera.takePicture(mShutterCallback, null, mJeCallback);
				}
			}
		});
		mSurfaceView = (SurfaceView) v.findViewById(R.id.crime_camera_surfaceView);
		//ÔÚSurfaceViewÖÐÒ»°ãͨ¹ýʹÓÃSurfaceHolderÀàÀ´¿ØÖÆCanvasÔÚÆäsurfaceÉϵIJÙ×÷
		SurfaceHolder holder = mSurfaceView.getHolder();
		//ΪÁ˽â¾ö¼æÈÝÐÔÎÊÌâ
		//SURFACE_TYPE_PUSH_BUFFERS±íÃ÷¸ÃSurface²»°üº¬ÔÉúÊý¾Ý£¬SurfaceÓõ½µÄÊý¾ÝÓÉÆäËû¶ÔÏóÌṩ£¬
		//ÔÚCameraͼÏñÔ¤ÀÀÖоÍʹÓøÃÀàÐ͵ÄSurface£¬ÓÐCamera¸ºÔðÌṩ¸øÔ¤ÀÀSurfaceÊý¾Ý£¬ÕâÑùͼÏñÔ¤ÀÀ»á±È½ÏÁ÷³©¡£
		holder.setType(SurfaceHolder.SURFACE_TYPE_PUSH_BUFFERS);

		//ÏìÓ¦surfaceµÄÉúÃüÖÜÆÚ
		//ΪSurfaceHolderÌí¼ÓÒ»¸öSurfaceHolder.Callback»Øµ÷½Ó¿Ú¡£
		holder.addCallback(new SurfaceHolder.Callback() {

			//µ±surface¶ÔÏóÔÚ½«ÒªÏú»ÙÇ°£¬¸Ã·½·¨»á±»Á¢¼´µ÷Óá£
			@Override
			public void surfaceDestroyed(SurfaceHolder holder) {
				// TODO Auto-generated method stub
				if( mCamera != null){
					mCamera.stopPreview();
				}
			}

			//µ±surface¶ÔÏó´´½¨ºó£¬¸Ã·½·¨¾Í»á±»Á¢¼´µ÷Óá£
			@Override
			public void surfaceCreated(SurfaceHolder holder) {
				// TODO Auto-generated method stub
				try {
					if(mCamera != null){
						//Á¬½ÓCamerayuSurface
						mCamera.setPreviewDisplay(holder);
					}
				} catch (IOException e) {
					// TODO: handle exception
					Log.d(TAG, "Error setting up preview display", e);
				}
			}

			//µ±surface·¢ÉúÈκνṹÐԵı仯ʱ£¨¸ñʽ»òÕß´óС£©£¬¸Ã·½·¨¾Í»á±»Á¢¼´µ÷Óá£
			@Override
			public void surfaceChanged(SurfaceHolder holder, int format, int width,
					int height) {
				// TODO Auto-generated method stub
				if(mCamera == null) return;

				//surface³ß´ç´óС¸Ä±äʱ£¬Éý¼¶ÏàƬµÄÔ¤ÀÀ³ß´ç
				//»ñȡϵͳ֧³ÖµÄÏà»úÔ¤ÀÀ´¢´æÁбí
				Camera.Parameters parameters = mCamera.getParameters();
				//Size s= null;
				//µÃµ½×î´óÊýÄ¿ÏñËصijߴç
				Size s = getBestSupportedSize(parameters.getSupportedPreviewSizes(), width, height);
				parameters.setPictureSize(s.width, s.height);//ÉèÖÃÔ¤ÀÀÖ¡Êý¾ÝµÄ³ß´ç
				s = getBestSupportedSize(parameters.getSupportedPictureSizes(), width, height);
				parameters.setPictureSize(s.width, s.height);
				mCamera.setParameters(parameters);
				if(getActivity().getResources().getConfiguration().orientation ==
						Configuration.ORIENTATION_PORTRAIT){
					Log.i("CrimeCameraFragment", "ÓÐûÓÐÔÚÊúÖ±ÅÄ×Å---------");
					mCamera.setDisplayOrientation(90);
				}
//				if (getActivity().getResources().getConfiguration().orientation == Configuration.ORIENTATION_PORTRAIT) {
//				       parameters.set("orientation", "portrait");
//				       parameters.set("rotation", 90);
//				       Log.i("CrimeCameraFragment", "ÓÐûÓÐÔÚÊúÖ±ÅÄ×Å---------");
//				    }
//				    if (getActivity().getResources().getConfiguration().orientation == Configuration.ORIENTATION_LANDSCAPE) {
//				       parameters.set("orientation", "landscape");
//				       parameters.set("rotation", 90);
//				       mCamera.setDisplayOrientation(90);
//				       Log.i("CrimeCameraFragment", "ÓÐûÓÐÔÚºá×ÅÅÄ×Å---------");
//				    }
				try {
					//ÓÃÀ´ÔÚSurfaceÉÏ»æÖÆÖ¡
					mCamera.startPreview();
				} catch (Exception e) {
					// TODO: handle exception
					Log.d(TAG, "could not start preview", e);
					mCamera = null;
				}

			}
		});

		return v;
	}
	//·½Ïò±ä»¯¼àÌýÆ÷£¬¼àÌý´«¸ÐÆ÷µÄ·½ÏòµÄ¸Ä±ä
	public class MyOrientationDector extends OrientationEventListener{

		int Orientation;
		public MyOrientationDector(Context context) {
			super(context);
			// TODO Auto-generated constructor stub
		}

		@Override
		public void onOrientationChanged(int orientation) {
			// TODO Auto-generated method stub
			Log.i("MyOrientationDetector ","onOrientationChanged:"+orientation);
			this.Orientation = orientation;
			Log.d("MyOrientationDetector","µ±Ç°µÄ´«¸ÐÆ÷·½ÏòΪ"+orientation);
		}
		public int getOrientation(){
			return Orientation;
		}

	}
	@TargetApi(9)
	@Override
	public void onResume() {
		// TODO Auto-generated method stub
		super.onResume();
		if(Build.VERSION.SDK_INT >= Build.VERSION_CODES.HONEYCOMB){
			mCamera =Camera.open(0);

		}else{
			mCamera = Camera.open();
		}
	}
	@Override
	public void onPause() {
		// TODO Auto-generated method stub
		super.onPause();
		//µ÷ÓÃÏà»úÏà¹Ø´úÂëʱ£¬¶¼Ó¦¼ì²éʵÀýÊÇ·ñ´æÔÚ
		if(mCamera != null){
			mCamera.release();
			mCamera = null;
		}
	}
}


"mAh" is another one of those confusing vaping terms you have probably either seen or heard of at least once while shopping for digital cigarettes. Generally, mAh is used to describe battery power—and you may have even correctly guessed that the higher the number, the stronger the battery. But what is the meaning of "mAh"? And perhaps an even better question: Why should you care?
mAh is short for "milliampere-hour" and coveys the total charge capacity of a battery. As a unit for measuring electrical power over a length of time, mAh is commonly used in describing how much energy a battery can store at one time. For instance, a battery rated at 1000 mAh can last for one hour delivering one amp of power (1,000 millamperes = 1 amp) before it is completely drained.
Thus, a fully-charged battery with a higher mAh rating can typically power a device that consumes more power for longer and/or stronger before it dies and needs to be re-charged.
The tradeoff? Batteries with more mAh also tend to be physically bigger and heavier.
Understanding mAh is necessary if you want to calculate how long your battery will last, as well as how many puffs each battery is capable of powering. First though, you have to know how much electrical current your battery and cartomizer use up when engaged.
For first-timers, this process can be a bit tricky. Start by dividing the voltage of your battery by the resistance level of your atomizer/cartomizer. For instance, according to this analysis on Vapegrl.com, a 2.5 ohm atomizer paired with a 3.7 volt battery—the most common e-cigarette configuration—would draw 1.48 amps (or 1480 mAh). If your battery or atomizer has a different voltage or resistance measurement, use the Ohm's Law Calculator to determine the electrical current drawn by your device (in amps) and then multiply it by 1000 to arrive at your milliampere number.
The final step in utilizing your knowledge of mAh battery rating is to estimate how many puffs you can get out of your e-cigarette before it dies. To determine this number, simply divide the total number of seconds you arrived at in the previous step by the number of seconds your average puff lasts. So, for instance, if your average puff is 3 seconds, using the example above you could get approximately 265 puffs out of one e-cigarette battery.
Calculating the lifespan of your digital cigarette battery isn't an exact science since resistance levels can vary by as much as 0.2 ohms up or down when in use, but this will at least give you a close idea of how long your battery will last.
For more battery tips, be sure to check out this article on how to increase your battery's life and save money in our Digital Cigarette Library.
Here at VaporFi, we cater to the advanced digital cigarette user who is looking to experience a higher level of vaping. One way we have accomplished this high standard is by upping the battery life on all of our e-cigarette models – that way you can stay out vaping for longer. Take a look at our advanced digital cigarettes for yourself and learn what makes VaporFi different today.


Too many water and sanitation programs stop short of full coverage, helping some but not others, due to poor planning. Often the areas skipped, are the poorest and hardest to reach communities. That's unacceptable.
Water For People Canada is an independent Canadian charitable non-profit organization organized to implement drinking water and sanitation projects that improve the health and welfare of local, regional and national populations in developing countries.
Water For People Canada partners with Water for People USA through an Agency Agreement approved by Revenue Canada for project support.
Information on upcoming events is shown below. Please check back often for the latest news and information on these events.
The Atlantic chapter of the charitable organization is affiliated with the Atlantic Canada Water & Wastewater Association (ACWWA), the local chapter of the American Water Works Association (AWWA) and Water Environment Federation (WEF).
Water For People benefits from the considerable resources of the AWWA and WEF, which have designated Water For People as their charity of choice.
Through the fundraising efforts of our local Water For People committee, money is raised to support Water For People international programs.
Water For People works to build a world where all people have access to safe drinking water and sanitation, and where no one suffers or dies from a water or sanitation related disease. This is our vision.
We're on a mission. We work with people and partners to develop innovative and long-lasting solutions to the water, sanitation, and hygiene problems in the developing world. We strive to continually improve, to experiment with promising new ideas, and to leverage resources to multiply our impact.
Four Guiding Principles. One Human Need.
We respect the dignity of all people.
We believe that water, sanitation, and hygiene problems are most effectively solved using local resources.
We search out trusted partners who share our vision and work together to build long-term relationships based on trust.
We believe we owe it to the communities we serve, our volunteers, staff, and donors to act with integrity and manage our resources effectively and efficiently.
Everyone - a simple word that we use everyday in casual conversation. Water for People has taken that word and given it a more complex meaning, one that asks us to take part in a more serious conversation.
The EVERYONE Campaign asks us to imagine a time when everyone - every family, every school, every clinic has access to safe water. We would like you to imagine a time when organizations like Water For People are no longer needed. Ambitious? Absolutely.
Just take a look at one of the countries that has made this pledge with Water For People. The Rwandan Government committed in October 2010 to have safe water coverage for 265,000 people in 494 villages in the Rulindo District by the end of 2014. Safe water access for Everyone. Every Family. Every School. Every Clinic. - https://www.waterforpeople.org/country-pages/rwanda/. Imagine.
Water For People has developed a unique model within the Non-Governmental Organization (NGO) water and sanitation sector. We are not interested in providing "handouts," we believe in giving a hand up. We don't believe in 100% funding of projects, we believe that success is founded on empowering local communities and government to build and sustain their own reliable safe water systems. We don't have beneficiaries, we have partners.
Our commitment to sustainability is more than just words, we will stay and monitor all of our projects for at least 10 years - and we will not be satisfied with anything less.
We have developed a revolutionary tool to do just that - FLOW (Field Level Operations Watch). FLOW measures what is working . . . and what is not working. Data is collected and analyzed by a dedicated group - the World Water Corps - who volunteer their time at their own cost to travel to our program countries. Check our Water For People-Canada webpage and meet the Canadians who volunteer with the World Water Corps.
The Everyone Campaign, the commitment to monitoring and sustainability, Water For People's talented staff, the dedication of our local committees throughout North America, and our World Water Corps team have made Water for People an organization to watch in the NGO sector. We attracted the attention of the Bill & Melinda Gates Foundation that recently gave Water For People a $5.6 million grant for the Sanitation as a Business Program, and Ned Breslin, Water For People's dynamic CEO, was awarded the 2011 Skoll Award for Social Entrepreneurship.
All of this has happened because Water for People is changing the conversation about ending water and sanitation poverty, forever. So, are you interested in being part of this conversation? Are you interested in being part of Everyone?
Everyone. Every family. Every school. Every clinic.
Upcoming events for ACWWA's Water For People committee will be posted here. Please check back often for the latest news.


text:
Home/Headache / Migraine/Things that causes a migraine
Things that causes a migraine
Other triggers
When to contact a doctor
A migraine cause is something that raises a person's chances of getting a migraine headache for a short period of time. Certain smells, foods, and even changes in the weather can be migraine triggers for some migraine sufferers.
A migraine does not occur every time a person is exposed to a stimulus. A migraine may be triggered by a combination of stimuli. These triggers can vary from one person to the next.
We'll go through different forms of migraine causes, how to manage them, and when to see a doctor in this post.
Hormonal changes, according to NINDS, can affect the incidence of migraine headaches in a number of ways.
Migraine headaches, for example, can strike during a woman's menstrual cycle or during pregnancy. They may also appear in women who begin taking birth control pills.
Migraine headaches can improve after menopause, according to NINDS.
Techniques for Managing
An individual should seek help from a healthcare professional, such as a headache specialist or gynaecologist, to find the best treatment plan for hormone-related triggers.
To help stabilise their hormone levels, a person may want to try birth control methods.
Emotional reactions and stress may be migraine triggers for some people. Stress is cited as a migraine cause by nearly 70% of sufferers.
Anxiety and depression are two other possible causes.
According to the AMF, an individual should make a list of stressors and try to reduce them in their daily lives.
They can also try the following:
biofeedback therapy
relaxation therapy
developing or maintaining a regular sleep schedule
Read full details about stress and how to manage it here.
Certain odours, according to AMF, can activate nerves in the nasal passages, resulting in a migraine headache. The following are some examples of triggers:
strong-smelling foods
Perfumes and other smells, according to the 2014 study, can trigger migraine headaches in 50% of migraine sufferers.
Migraine sufferers may reduce their sensitivity to possible causes by using unscented products.
Foods and additives cause migraine headaches in about half of the people who suffer from them.
The following are examples of possible triggers:
aspartame, which is an artificial sweetener
caffeine or caffeine withdrawal
alcohol, especially red wine
certain fruits and nuts
aged cheeses
pickled or fermented products
processed or cured meats
Plant food was found to be a migraine cause for 40.3 percent of people in a 2021 survey of 3,935 migraine sufferers, with the pain occuring within 90 minutes of eating the food.
Watermelon was the most common trigger in the study, causing headaches in 29.5 percent of the participants.
A food journal can be used to help recognise the foods that cause migraine headaches.
Bright or blinking lights, according to the National Institute of Neurological Disorders and Stroke (NINDS), can cause migraine headaches.
According to a 2014 report, about 40% of migraine sufferers experience a migraine attack as a result of visual stimulation. According to neuroimaging, migraine sufferers have a distinct brain structure that processes visual details.
According to the review's writers, migraine sufferers tend to be more sensitive to bright and flickering lights.
Migraine sufferers can also suffer from a disorder known as photophobia. This is a light sensitivity that can occur even when a person is not suffering from a migraine.
When outside, an individual can find it beneficial to wear sunglasses. Furthermore, if a person is in an artificially lit setting, they should try to sit closer to the windows. It's also a good idea to stay away from sources of flickering light.
Green light, according to the American Migraine Foundation (AMF), is unlikely to cause a migraine. It is possible to look for bulbs that emit green light.
Migraine sufferers are more susceptible to sound. According to the National Institute of Neurological Disorders and Stroke, loud or sudden noises may be a migraine trigger for some people. Around 50–75 percent of migraine sufferers will experience this.
It can be difficult to stay away from loud noises. Avoid spending time in loud and chaotic places, such as movie theatres and packed bars, if at all possible. In noisy environments, they may want to consider wearing hearing protection.
A little more than a third of migraine sufferers report that certain types of weather will cause a migraine attack.
So far, there is no definitive evidence that weather conditions play a role in migraine headaches. However, some migraine sufferers may be vulnerable to the following weather changes, according to studies:
a drop in barometric pressure
long periods of sunshine
Other potential migraine triggers may include:
too much or not enough sleep
overexertion
A migraine sufferer should eat regularly and drink plenty of water if at all possible. In addition, they should get 7–8 hours of sleep a night.
Preventive treatment could be appropriate for people who experience migraine attacks at least once a week.
The following medications can aid in the prevention of migraine attacks:
botulinum toxin A
Aimovig and similar drugs, which block the action of a molecule called calcitonin gene-related peptide
triptan drugs, which are available as tablets, nasal sprays, and injections
ergot derivative drugs, which are available as injections and nasal sprays
over-the-counter pain relievers
nonsteroidal anti-inflammatory drugs
antinausea medication, also known as antiemetic drugs
lasmiditan (Reyvow), which is a type of serotonin receptor agonist
Inhibitors of the calcitonin gene-related peptide (CGRP) can also be prescribed by a doctor. These medications tend to reduce the number of migraine headaches and have less warnings and precautions than other forms of migraine drugs, according to the Food and Drug Administration (FDA).
Inhibitors of CGRP include:
ubrogepant (Ubrelvy)
rimegepant (Nurtec)
erenumab (Aimovig)
fremanezumab (Ajovy)
galcanezumab (Emgality)
An individual may take a number of measures to alleviate migraine symptoms. There are some of them:
resting in a dark, quiet room with the eyes closed
placing an ice pack or cool cloth on the forehead
drinking plenty of fluids
consuming a small amount of caffeine
If a person's migraine headaches are regular or extreme, and the symptoms are interfering with their everyday life, they should seek medical advice.
A doctor can prescribe medication or assist in the development of a migraine treatment plan.
If a person has a headache that includes the following symptoms, they should seek medical help right away.
is severe and co-occurs with a stiff neck, fever, nausea, or vomiting
is the worst a person has ever experienced
follows a head injury
co-occurs with weakness or numbness in any part of the body
occurs with convulsions or shortness of breath
Migraine headaches can be triggered by a variety of things, including bright or blinking lights, loud noises, stress, and the weather. Migraine sufferers should avoid any migraine causes if at all necessary.
Migraine causes differ from person to person. Keeping a migraine journal may assist in identifying these.
Changes in exercise, diet, and sleep habits can also aid in the prevention of migraine headaches.
Medication may be used to alleviate migraine symptoms or reduce the frequency of potential attacks.
Digre, K. B. (2016). Photophobia – What is it? Can it be treated?
https://americanmigrainefoundation.org/resource-library/what-is-photophobia/
Headache: Hope through research. (2019).
https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Hope-Through-Research/Headache-Hope-Through-Research
Lamb, Y. N. (2019). Lasmiditan: First approval [Abstract].
New drug class employs novel mechanism for migraine treatment and prevention. (2019).
https://www.fda.gov/drugs/news-events-human-drugs/new-drug-class-employs-novel-mechanism-migraine-treatment-and-prevention
Schwedt, T. J. (2014). Multisensory integration in migraine.
What can trigger a migraine? https://www.medicalnewstoday.com/articles/migraine-triggers?
Silva-Néto, R. P., et al. (2021). Watermelon and others plant foods that trigger headache in migraine patients [Abstract].
https://www.tandfonline.com/doi/abs/10.1080/00325481.2021.1922211?journalCode=ipgm20
Top 10 migraine triggers and how to deal with them. (2017).
https://americanmigrainefoundation.org/resource-library/top-10-migraine-triggers/
Weather and migraine. (2016).
https://americanmigrainefoundation.org/resource-library/weather-and-migraine/
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Everything you need to know about migraines


Description: Atlantida FilmFest is a cinema festival organized by the VOD Filmin platform, with an online part and another on-site part in Palma. It's aimed to reflect the main problems that concern Europe, PowerHouse Hub works on the production of this event that takes place in 5 different locations. Cinema, concerts, round tables , professional conferences… are a part of this big cinematographic event.
Objectives: Coordination of the production of the event.


$143.44 $176.00 Save 19% Current price is $143.44, Original price is $176. You Save 19%.
Electric power providers around the world rely on stability analysis programs to help ensure uninterrupted service to their customers. These programs are typically based on step-by-step numerical integrations of power system stability models to simulate system dynamic behaviors. Unfortunately, this offline practice is inadequate to deal with current operating environments. For years, direct methods have held the promise of providing real-time stability assessments; however, these methods have presented several challenges and limitations.
This book addresses these challenges and limitations with the BCU methods developed by author Hsiao-Dong Chiang. To date, BCU methods have been adopted by twelve major utility companies in Asia and North America. In addition, BCU methods are the only direct methods adopted by the Electric Power Research Institute in its latest version of DIRECT 4.0.
Armed with a solid foundation in the underlying theory of direct methods, energy functions, and BCU methods, you'll discover how to efficiently solve complex practical problems in stability analysis. Most chapters begin with an introduction and end with concluding remarks, making it easy for you to implement these tested and proven methods that will help you avoid costly and dangerous power outages.
Hsiao-Dong Chiang, PhD, a Fellow of IEEE, is Professor of Electrical and Computer Engineering at Cornell University. Dr. Chiang is the founder of Bigwood Systems, Inc., and Global Optimal Technology, Inc., as well as the cofounder of Intelicis Corporation. Dr. Chiang's research and development activities range from fundamental theory development to practical system installations. He and his group at Cornell have published more than 300 refereed journal and conference papers. Professor Chiang's research focuses on nonlinear system theory and nonlinear computations and their practical applications to electric circuits, systems, signals, and images. He has been awarded ten U.S. patents and four patents from overseas countries.
1.2 Trends of Operating Environment.
1.4 Need for New Tools.
1.5 Direct Methods: Limitations and Challenges.
1.6 Purposes of This Book.
2. System Modeling and Stability Problems.
2.2 Power System Stability Problem.
2.3 Model Structures and Parameters.
2.5 Power System Stability Problems.
2.6 Approaches for Stability Analysis.
3. Lyapunov Stability and Stability Regions of Nonlinear Dynamical Systems.
3.2 Equilibrium Points and Lyapunov Stability.
3.4 Stable and Unstable Manifolds.
3.6 Local Characterizations of Stability Boundary.
3.7 Global Characterization of Stability Boundary.
3.8 Algorithm to Determine the Stability Boundary.
4. Quasi-Stability Regions: Analysis and Characterization.
4.3 Characterization of Quasi-Stability Regions.
5. Energy Function Theory and Direct Methods.
5.4 Estimating Stability Region Using Energy Functions.
5.5 Optimal Schemes for Estimating Stability Regions.
5.6 Quasi-Stability Region and Energy Function.
6. Constructing Analytical Energy Functions for Transient Stability Models.
6.2 Energy Functions for Lossless Network-Reduction Models.
6.3 Energy Functions for Lossless Structure-Preserving Models.
6.4 Nonexistence of Energy Functions for Lossy Models.
6.5 Existence of Local Energy Functions.
7. Construction of Numerical Energy Functions for Lossy Transient Stability Models.
7.5 Numerical Evaluations of Approximation Schemes.
7.7 On the Corrected Numerical Energy Functions.
8. Direct Methods for Stability Analysis: An Introduction.
9. Foundation of the Closest UEP Method.
9.4 Characterization of the Closest UEP.
9.6 Improved Closest UEP Method.
9.7 Robustness of the Closest UEP.
10. Foundations of the Potential Energy Boundary Surface Method.
10.2 Procedure of the PEBS Method.
10.3 Original Model and Artifi cial Model.
10.5 A Class of Second-Order Dynamical Systems.
10.6 Relation between the Original Model and the Artifi cial Model.
10.7 Analysis of the PEBS Method.
11. Controlling UEP Method: Theory.
11.4 The Controlling UEP Method.
11.5 Analysis of the Controlling UEP Method.
11.7 Dynamic and Geometric Characterizations.
12. Controlling UEP Method: Computations.
12.3 Constrained Nonlinear Equations for Equilibrium Points.
12.4 Numerical Techniques for Computing Equilibrium Points.
12.5 Convergence Regions of Equilibrium Points.
12.6 Conceptual Methods for Computing the Controlling UEP.
13. Foundations of Controlling UEP Methods for Network-Preserving Transient Stability Models.
13.5 Energy Functions for Network-Preserving Models.
13.6 Controlling UEP for DAE Systems.
13.7 Controlling UEP Method for DAE Systems.
14. Network-Reduction BCU Method and Its Theoretical Foundation.
14.4 Static and Dynamic Relationships.
14.6 A Conceptual Network-Reduction BCU Method.
15. Numerical Network-Reduction BCU Method.
16. Network-Preserving BCU Method and Its Theoretical Foundation.
16.3 Static and Dynamic Properties.
16.5 Overall Static and Dynamic Relationships.
16.7 Conceptual Network-Preserving BCU Method.
17. Numerical Network-Preserving BCU Method.
17.3 Numerical Scheme to Detect Exit Points.
17.5 Computation of Equilibrium Points.
18. Numerical Studies of BCU Methods from Stability Boundary Perspectives.
18.2 Stability Boundary of Network-Reduction Models.
18.4 One Dynamic Property of the Controlling UEP.
19. Study of the Transversality Conditions of the BCU Method.
19.3 Analytical Investigation of the Boundary Property.
19.4 The Two-Machine Infi nite Bus (TMIB) System.
20. The BCU–Exit Point Method.
20.3 Computation of the BCU–Exit Point.
20.4 BCU–Exit Point and Critical Energy.
21. Group Properties of Contingencies in Power Systems.
21.2 Groups of Coherent Contingencies.
21.3 Identifi cation of a Group of Coherent Contingencies.
22.2 Group-Based Verifi cation Scheme.
22.3 Linear and Nonlinear Relationships.
22.4 Group-Based BCU–Exit Point Method.
23.2 Exact Method for Computing the Controlling UEP.
24.2 Group-Based BCU Method for Accurate Critical Energy.
24.3 Group-Based BCU Method for CUEPs.
25. Perspectives and Future Directions.
25.2 Online Dynamic Contingency Screening.
25.4 Phasor Measurement Unit (PMU)-Assisted Online ATC Determination.
A1.2 Proofs of Theorems in Chapter 9.
A1.3 Proofs of Theorems in Chapter 10.


Warning! The following article was written with SEVERE jetlag. All grammar errors, words and opinions are not ours.
Walk, Ferry, Shuttle Bus, Airport bus.
Hour queue for check in.
Enjoy 5 movies, two meals, one snack box and one unidentified vegetarian warm food item on 17 hour flight leaving Auckland at 15.30 to Doha. Arrive into Doha at midnight (on the same day?!?) and hang out at the sixth airport to be awarded five stars.
At 2am Doha time we eat a burger in a food court as we are both starving (Stomach's revenge for red wine overload?). I think I see a giant teddy bear but my mind is sleep deprived and confused.
I think I meet George Cloony but my mind is sleep deprived and confused.
Turns out we use the same hair products.
At 4.30am we check in for our 7 hour flight to sunny Blighty. We consume 3 movies, one meal and a veggie pasty thing.
At 11am we land on the damp rock in the north east Atlantic that is home. I think this means it has taken thirty and a half hours to get from Auckland to London but my brain is tired.
Al wins carousel rucksack roulette taking the final trip score to Al 4-2 Guy. She wins the casting vote in our flat hunt.
Alison's wonderful parents and our new landlords meet us at the airport.
Bus, Bus, Train, Car and within five hours of being in the country we are in Waitrose perusing the Kiwi wine selection.
Thankfully Fitbit don't record alcohol units consumed.
We go to bed at 7pm in full daylight.
Wherever I lay my hat, that's my home.
Today we make our penultimate journey of this trip, it will be a mixed bag of transport, taxi, teeny plane, bus, ferry, bus.
We have booked an internal flight with Air New Zealand as it was cheaper than the bus and it saved us an overnight in Auckland.
So, on our last Monday away, as everyone at home was having a bank holiday lie in we were up early. We packed and left our glamping tent, which had been battered by wind and rain the night before, and got on our way to the small but beautiful Napier airport.
We checked in our bags, as they had bottles of wine carefully packed throughout we asked that they have the fragile tags put on. They were duly tagged.
Breakfast was pastry based with Hawthorne coffee to wash it down. We watched as the baggage handlers threw our bags into the baggage hold on our plane. Fragile tags duly ignored.
The wind had really picked up so it was with trepidation that we boarded the small, propeller driven plane. It was bumpy on the way up but once up it was a breeze.
55 mins later we are in Auckland and on our way into town for the ferry to the beautiful island of Waiheke, where we had booked a bit of luxury for our last 3 nights of the trip.
The 35 min ferry journey was stunning, many photos were taken.
Landing on the tiny island we got a bus the 2km into Oneroa, luxury, and got into our Air BnB to see what we have for the last time. Washing machine and dryer are the essentials as I don't want to go back to Mum and Dad's with a bag full of washing. Mum never did my washing when I was a student so I doubt it will be gratefully received on Friday!!!
Our place has views front and back to the seaside. How ace?
We got some fancy items from the posh Island Grocer and essentials from Four Square and went back to the flat to do washing and cook up some lamb merguez sausages for a late lunch.
Guy cooked a stunning evening meal of lamb meatballs, couscous and adds green leaves for health.
It was accompanied by 2 very fine Pinot Noirs for which we were grateful to be drinking due to Guy's diligent packing and not the Air NZ baggage handlers. We watch The Bachelor and MKR.
We had packed and vacated the room early as a jet lagged English couple had landed after an overnight flight from Japan so needed the room more than us!!
We have really enjoyed staying at Mt Eden and Richard's house, and today when we went for coffee and the sprightly Italian owner said 'the usual' we were dead chuffed. Coffee was swigged along with a small shot of amaretto as a 'happy anniversary' present from my wonderful husband.
We sauntered up and down Mt Eden one last time. As it was Good Friday there were many more people that the previous few days and Cyclone Cook was a distant memory, the views were fab.
We finished all our food off in one massive brunch style dish and decided we didn't need to eat ever again after that.
We had picked up a horned melon from the local fruit and veg shop, $3.99 each, and all of us who tried the fruit agreed it was a one off experience, not to be repeated. Fresh, green tasting with lots of seeds, not sure you would sprinkle it on a pork chop….
Our final overnight bus journey of the trip is tonight, so we have another day of killing time. We dropped bags off at Britomart station and wandered down Auckland downtown with the intention of having a leisurely pint or glass of vino to celebrate 16 wonderful years of marriage. However we had not taken into account the stringent public holiday drinking laws here. Unless we had a full main course meal each then we cannot be served any wine. Wow! What do you do on a bank holiday weekend if it isn't meeting your mates in the pub for a sesh?
We couldn't face any more food so wandered, chatted, wandered some more.
The overnight journey was quick, with food stops at 11.30pm and 3am. People got off and ate on the 3am stop!!!
So the healthy caffeinated run up and down an extinct volcano exercise routine is in full swing. We did it again and see yet more Chinese tourists checking out the views.
We walk over to the Domain, a huge expanse of green grass in the centre of Auckland, it also has a hothouse and fernery. Ace.
Over the otherside of the Domain is Newmarket, which we head to as we are starving and spot a few Taiwanese, Japanese, Chinese and dumpling restaurants. Dumplings win, along with a glass of kiwi white wine each.
A spot of jeans shopping later and we were sorted. Guy tried on 3 pairs, I tried on slightly more.
I threw together a tuna nicoise salad back at home.
and we did a double header on the movies and wine. Mad Max Fury Road, followed by The secret life of Walter Mitty.
We are determined to get home being able to fit into our clothes in storage so are embarking on an exercise regime which involves getting caffeined up to the eyeballs then running up and down an extinct volcano every day, we will write a self help book about it when we get home and make a fortune.
Day One and we did an 11 min walk to Rad for Guy to have their famous flat white. I stuck with a reliable long black (as opposed to a short black which is an espresso). Guy liked the flat white as it was less milky and more coffee than the usual frothy, milky coffee concoctions.
We had a light jog up aforementioned volcano and were greeted with even more Chinese tourists than yesterday.
Back down the volcano and Guy cooked up a hearty breakfast of huevos rancheros which we demolished in seconds.
We had a wander down Dominion Road nearby and checked out the Chinese quarter, it was too early for dumplings so we carried onto Mt Eden shops which are varied and include an allotment, the likes of which I have never seen before.
We then carried on past a small kids playground with a bucket contraption in it. Like Aquarama in Bennicassim, if anyone has been there.
Back in Mt Eden and we chance upon an independent wine shop. What are the chances of that? We chatted to the chap in the shop for sometime, purchased 2 bottles of wine and went home to plan and book much of the remaining time we have left accompanied by a bottle of Sauvignon Blanc.
We watched Hateful Eight on our 42″ TV in our room and drank Pinot Noir.


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Morgan Stanley Upgrades Nuance Communications (NASDAQ:NUAN) to "Overweight"
Posted by Liza Goodheart on Jan 16th, 2020
Morgan Stanley upgraded shares of Nuance Communications (NASDAQ:NUAN) from an equal weight rating to an overweight rating in a report issued on Monday, Benzinga reports. They currently have $23.00 price objective on the software maker's stock, up from their prior price objective of $15.00.
NUAN has been the subject of a number of other reports. Zacks Investment Research cut Nuance Communications from a buy rating to a hold rating in a report on Thursday, October 3rd. TheStreet raised Nuance Communications from a c+ rating to a b rating in a report on Wednesday, November 20th. ValuEngine cut Nuance Communications from a buy rating to a hold rating in a report on Wednesday, November 20th. Barclays cut their price target on Nuance Communications from $20.00 to $17.00 and set an overweight rating for the company in a report on Monday, October 7th. Finally, Wedbush assumed coverage on Nuance Communications in a report on Friday, September 27th. They issued an outperform rating for the company. Two equities research analysts have rated the stock with a sell rating, one has assigned a hold rating and four have issued a buy rating to the company. Nuance Communications currently has a consensus rating of Hold and a consensus target price of $20.80.
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Nuance Communications stock opened at $19.45 on Monday. The stock has a 50-day simple moving average of $17.96 and a 200 day simple moving average of $16.76. The company has a quick ratio of 0.68, a current ratio of 0.68 and a debt-to-equity ratio of 0.37. Nuance Communications has a 12-month low of $14.02 and a 12-month high of $19.48. The stock has a market capitalization of $5.48 billion, a price-to-earnings ratio of 25.59, a P/E/G ratio of 7.76 and a beta of 0.95.
Nuance Communications (NASDAQ:NUAN) last released its quarterly earnings results on Wednesday, November 20th. The software maker reported $0.34 earnings per share (EPS) for the quarter, beating the Zacks' consensus estimate of $0.28 by $0.06. Nuance Communications had a return on equity of 12.42% and a net margin of 11.83%. The business had revenue of $471.97 million during the quarter, compared to analysts' expectations of $486.13 million. During the same period in the previous year, the business posted $0.38 earnings per share. The firm's revenue for the quarter was down 2.1% compared to the same quarter last year. As a group, sell-side analysts anticipate that Nuance Communications will post 0.5 EPS for the current year.
In related news, EVP Wendy Cassity sold 12,653 shares of Nuance Communications stock in a transaction dated Wednesday, December 11th. The stock was sold at an average price of $17.83, for a total value of $225,602.99. Following the completion of the sale, the executive vice president now directly owns 111,337 shares in the company, valued at $1,985,138.71. The sale was disclosed in a filing with the SEC, which is available through the SEC website. Also, EVP Thomas L. Beaudoin sold 12,355 shares of Nuance Communications stock in a transaction dated Friday, November 15th. The stock was sold at an average price of $16.60, for a total value of $205,093.00. Following the completion of the sale, the executive vice president now owns 255,884 shares of the company's stock, valued at $4,247,674.40. The disclosure for this sale can be found here. Over the last quarter, insiders sold 63,374 shares of company stock valued at $1,108,662. Corporate insiders own 0.50% of the company's stock.
Hedge funds have recently made changes to their positions in the stock. Tower Research Capital LLC TRC acquired a new stake in Nuance Communications in the second quarter worth about $26,000. Evoke Wealth LLC acquired a new stake in Nuance Communications in the third quarter worth about $30,000. Pinebridge Investments L.P. increased its position in Nuance Communications by 24.0% in the second quarter. Pinebridge Investments L.P. now owns 4,645 shares of the software maker's stock worth $74,000 after purchasing an additional 900 shares during the period. Cerebellum GP LLC acquired a new stake in Nuance Communications in the third quarter worth about $80,000. Finally, US Bancorp DE increased its position in Nuance Communications by 56.9% in the second quarter. US Bancorp DE now owns 5,830 shares of the software maker's stock worth $93,000 after purchasing an additional 2,114 shares during the period. Hedge funds and other institutional investors own 90.47% of the company's stock.
Nuance Communications Company Profile
Nuance Communications (NASDAQ: NUAN) is the pioneer and leader in conversational AI innovations that bring intelligence to everyday work and life. The company delivers solutions that understand, analyze, and respond to people – amplifying human intelligence to increase productivity and security. With decades of domain and AI expertise, Nuance works with thousands of organizations globally across healthcare, financial services, telecommunications, government, and retail – to create stronger relationships and better experiences for their customers and workforce.
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M.A.P.T. was organized in 1965 as a non-for profit 501c (6) association for pupil transportation professionals in the state of Missouri. The Association Membership is composed of Pupil Transportation professionals such as: Superintendants, Transportation Directors, Managers, Supervisors, Trainers, Fleeet Superivors, Maintenance technicians and more sharing a common goal of transporting the students of Missouri safely, effectively and consistntly, ensuring they have access to their educaitonal setting - "We Connect What Matters"


Not my home, now. But Home with a capital letter. Home, as in, "you can't go home again." Except that I do, usually about once a month or so. My mother still lives in the apartment that she and my dad rented near Uptown Whittier when I was in junior high. Temporary, they said at the time. Because while we had always been renters, we had never before lived in an apartment. No yard? No front porch? How would we all manage? Now it's almost thirty years later, and still the same address.
I'm going to let the pictures do most of the talking here. I guess this is sort of a belated Weekend Recap post -- these were taken on Super Bowl Sunday.
This is the back of my bedroom door. I don't remember when I put up the Led Zep -- but I cut the letters and symbols out of a poster and glued them up -- I guess with some pretty heavy duty glue, as they're still there. My dad moved into this room after I got married (yes, I lived at home right up until my wedding day, with only a brief 9 months away at an out-of-state college). He tried to chip off the letters, but to no avail.
Shortly after I was married, my dad was diagnosed with emphysema. He eventually ended up needing an oxygen tank and some other sort of major breathing machine (like a tank, but less portable). He moved into this room, and toward the end of his life, he rarely left. He had his computer, a TV for round-the-clock viewings of Law & Order and other cable police shows -- and his displays. This shelf held his display of vintage roadrunners. (Shortly after I took this picture, my mom said she took down the display. Almost 3 years after my dad died, and it's still hard to put away all of his things.) After his years as bartender, my dad got very into thrifting and selling at flea markets. For a while, he had his own shop: Roadrunner Antiques.
The view out my bedroom window. This is "Across the Street," also currently known as a Circle K -- before that, it was a Stop N' Go. We have always, always just referred to it as Across the Street: as in, "I'm going across the street for some Dr.Pepper, do you need anything?" (Usually yes, since my mother ALWAYS needs a half-gallon of milk.) At night, and on clear days, the view is long and southward -- one can see clear to Signal Hill, near Long Beach. During the summer in high school, I would cross for bags of chips and Icees, wearing short shorts and testing my ability to stop traffic and garner hoots and hollers from passing cars. I was both thrilled and embarrassed. It's like a short story from Joyce Carol Oates or something.
Vintage cuteness in the first bathroom. Yes, an apartment with 2 full baths and 3 bedrooms, and more than 1,000 square feet. We never felt crowded.
The view out a front window, looking east. Less than 2 miles east up the road, this major street, which you can drive west all the way to Beverly Hills and beyond, turns into Turnbull Canyon. The canyon is winding and rural and wild and it never felt far away, even in the midst of the traffic noise and bustle. Even now, at night, one can smell the proximity of all that brush and chapparal. High school kids like to cruise the canyon on Saturday nights at way-too-high speeds, blasting Ozzy Osbourne out the car speakers. Not that I'd know anything about that.
Me and my sister (I'm the curly one.) In the background you can see some of the other vintage elements in the house that we take for granted: the old icebox, that we've had forever, the Frankoma pottery above the pantry, the clock, the De Grazia print.
Lily with a mouth full of Super Bowl cupcake. Behind her is the antique cabinet holding my mom's collection of ceramic Florence dolls. Florence dolls were made in Pasadena, Califonia in the 1940s and '50s. These gals was acquired by my dad, almost exclusively on Ebay. Neither the cabinet or the dolls are secured in any way to the wall -- one good earthquake, and they're toast! I have harped on my mother for years to fix this --- not my problem, I suppose.
The view from the balcony, looking northeast: The hills are very green right now, says mom. Whittier is a terrific walking town, especially on the west side: alleys, overgrown bougainvillea, bungalow homes and curvy, steep, narrow streets. There are trails that lead up into the hills, too. Ah, the green, green grass of Home.


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Insurance is an important part of a financial plan – even those who are young, don't have children or are not the main breadwinner of a family should have some form of protection. That said, choosing the right type of insurance for your life stage and financial needs is key. For example, young professionals may want to consider critical illness or disability insurance to help manage expenses if an illness or disability prevents them from working, whereas middle-aged consumers might benefit most from a permanent life insurance policy. Your advisor can help you find the right protection for your life and wealth stage.
It used to be that applying for insurance was a complicated process involving face-to-face meetings, lengthy applications and the need to provide blood and urine samples. Now applications are simpler. Many can be completed online without having to meet in person and can also be signed electronically. In most cases, medical exams and fluid samples are a thing of the past. Today, approvals are quick, and coverage can be in place as little as 48 hours after you apply.
But the truth is, the right coverage can be designed to fit comfortably into your life and financial plan. Term life insurance, for example, is a cost-effective solution that can provide protection for a specific length of time. And some new programs allow consumers to earn premium reductions and other rewards, based on making healthy lifestyle choices.
Making a decision that can safeguard your family's lifestyle is a great feeling. Not only that, there are a range of innovative solutions that help keep you motivated to make healthy lifestyle choices. Programs that incorporate goal setting, activity tracking and rewards for everyday accomplishments can encourage positive habits that can lead to lasting health benefits. When you consider the advancements and choices available, it's clear that getting the necessary protection may actually be one of the easiest parts of implementing a financial plan. Speak with your advisor to determine what type of insurance and how much coverage is best suited for your needs.
Term life insurance provides protection at a guaranteed rate for a specific period, such as 10 or 20 years. At the end of the term, if you want to keep your protection, you can renew the policy or convert it to permanent insurance.
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Even if you have insurance through a benefits plan at work, it may not be enough to maintain your family's current standard of living in the event of a death, sickness or disability. In households where the primary wage earner is covered by group insurance only, the average amount of coverage will replace income for only two years. An individual policy can help top up your benefits – and stay with you, even if you change jobs.


text:
000: Fifty Puppies and a Podcast: Intro to Nancy and Harold Rhee
Have you ever wondered what it takes to place a stray animal in a permanent home? On Pawprint, you'll meet the everyday heroes of animal rescue who use hard work, dedication, and out-of-the-box ideas to give homeless pets a second chance.
What is a rescue organization?
It can be one person with a passion for saving animals, or it can be a comprehensive organization with paid staff, a shelter, an animal hospital, and a network of volunteers. The mission is to save dogs, cats, and other animals from homelessness, and place them with a permanent, or "forever," home.
Rescue organizations also advocate for animals. For example, changes in laws to protect animals, reduce irresponsible breeding (like puppy mills), and spread the word on the importance of spaying and neutering animals.
Two rescue organizations we mention in this episode:
East Bay SPCA with locations in Oakland and Dublin, California.
Tony La Russa's Animal Rescue Foundation, also known as ARF, in Walnut Creek, California.
What is a foster?
A person, a group, or family, who temporarily take in one or more animals in preparation of finding a permanent, or forever, home.
The animals often need to get spayed or neutered, vaccinated, and treated for a wide range of health issues, and socialized to get along with people and other animals.
Some animals only need fostering for a few days, while others may take months to find that special forever home.
Nancy and Harold have fostered over 50 dogs, which is one of the reasons we started Pawprint, to get you inspired and moving!
We share inspirational stories from leaders, volunteers, and experts in animal rescue, health, and behavior.
If you want to learn more about us, here's some random stuff about your adorable Pawprint co-hosts:
Harold grew up in Buffalo, New York. He is a long-suffering Buffalo Bills football fan. Even though he lives in San Francisco 49ers and Oakland Raiders country, he refuses to change his allegiance! Our son Dylan, by the way, is a 49ers fan.
Nancy grew up in Seoul, South Korea, and speaks three languages – English, Korean, and Japanese. She grew up with dogs in Korea and while living in New York City had a cat named Smitty.
Thanks for listening, and send us feedback and ideas! thisispawprint@gmail.com
All of Pawprint's music is composed by Luke Gartner-Brereton. Luke is a musician based in Australia, and he composes a wide variety of songs and musical loops http://vanillagroovestudios.com
http://soundcloud.com/luke-gartnerbrereton
If you want to learn more about Nancy and Harold, go to our About Us page at thisispawprint.com/about or listen to our introductory podcast episode, "Fifty Puppies and a Podcast." http://thisispawprint.com/000


David is the founder of the New Mexico Art History Conference (1986) and former curator of the University of New Mexico's Harwood Museum of Art in Taos (1979-2005). He has written and produced scores of exhibitions and articles on the art and art history of New Mexico. He holds degrees from Kansas State University and the University of Oklahoma.
David is the author of four award-winning books: Ernest Thompson Seton, The Life and Legacy of an Artist and Conservationist (2010), Modernists in Taos from Dasburg to Martin (2002), Spirit Ascendant: The Art and Life of Patrociño Barela (1996), and Taos Moderns: Art of the New (1992).
Recent e-books include a novel, The Prairie Suite, An Old World, a New Beginning (2014), and a nonfiction work, Generally True Patterns, A New Natural History of Recognizing Ourselves as a Part of Nature (2015). He writes two blogs: one on Seton, and a second on history and environmental topics, illustrated with his photography.
David L. Witt has not published any news yet.


Great Benefits Quality Sewer lines .
Every city must have a proper drainage system in order to ensure that there is no house resurfing. It is the responsibility of every city heads to ensure this does not happen. Every household in Oklahoma is fitted with water heaters that are used by the residents this water heaters in Oklahoma city are sold at different prices to ensure that each and everyone gets to afford them. The sewer lines in Oklahoma city are well managed by the city council people.
They use technological means to monitor them to ensure that in the event of any breach they contain it before it worsens. Oklahoma city plumbing company steps in so as to handle complex task that could not have been handled by the technical team.
Oklahoma city is one of the cold cities and that is why there is the water heater Oklahoma city company that is responsible for providing the residents with the water heaters and also fit them at their houses. This services is done at prices that the consumers can purchase. Since there is creation of job opportunities life standards is improved as those working on these plumbing companies can be able to cater for their needs.
Warm water in showers is preferred by the Oklahoma people as there embark from their work. They is able to concentrate on the day's activities and relax. There are different types of the water heaters in the market today. They differentiate in terms of size, prices and power consumption. People tend to think that water heaters consume a lot of electricity this is false because it is designed in a way that it is able to take in little electric volume and produce more heat.
Sewer lines are also prone to damages even though they are found underground. Corrosion and blockage are problem associated with sewer lines since they deal with water. The problem caused by the blockage can be dealt with by the Oklahoma city sewer lines. Sewer lines also require cleaning from time to time. The dirt that could have caused the sewer lines to stop functioning is easily removed by cleaning.
Water supply services are easily done by the Oklahoma city company to the newly constructed houses. Kitchen, bathrooms and toilets are the key areas that needs concentration due water concentration in those areas. The owners of the houses are the ones to choose if the re-circulation of pumps will be used or there will be installation of the sewer lines.


In May 2012, my friend noticed that my abdomen looked bloated and advised me to seek medical consultation.
I went to the Polyclinic and was referred to the KK hospital for a scan. After the scan, I was found to have 3 fibroids, 1 cyst and my endometrium was rather thick for a post-menopausal person. After several follow-up scans, I was advised to go for a biopsy. With the medical advice, I did not feel at ease and decided to seek a second opinion from a private doctor in June 2013. He too advised me to do a surgery to remove them.
During the sermons in church, I prayed and pleaded with the Lord for healing and not have to go through any surgery. I made my pleas to the Lord with many "whys". Many times I would put my hand on the affected areas during the calls by our pastors for healing. My cell group also prayed for me.
Still going for regular scans and with the doctors kept telling me to go for the operation, I kept praying that these unwanted tissues would be reduced or disappear with the Lord's touch. In April 2015 I was told to go for financial counselling by KK Hospital for the operation. Then, my cousin also recommended me to a Christian TCM practitioner. She prescribed medicine for me to take. I told her that I was still praying for healing from the Lord. After many rounds of medication, she was happy to feel the fibroids going smaller and smaller.
It was 6 years back and the Lord heard me and healed me. Thank you, Lord, for your healing touch! As one sister wrote me this as confirmation – "any sickness and disease will not prevail over you".


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Home Breaking News 'Vaccine passports' may be a bad idea, say health experts
'Vaccine passports' may be a bad idea, say health experts
PETALING JAYA,Feb 25: Two public health experts have raised a number of concerns over a proposal to issue so-called "vaccine passports" to travellers who have been inoculated against Covid-19.
The fear that the passport could be viewed as discriminatory was among the issues raised by Dr Awang Bulgiba Awang Mahmud of Universiti Malaya and Dr Chan Chee Khoon of Citizens Health Initiative in interviews with FMT.
Both are epidemiologists and they spoke of ethical implications and issues of implementation.
With the National Covid-19 Vaccination Programme officially under way, many in the tourism and aviation industry have expressed optimism that a vaccine passport could be the key to reviving international travel.
The International Air Transport Association is already developing such a system and is planning to launch its mobile app next month.
Awang Bulgiba said one could question whether such a system would be possible given the lingering uncertainties over the number of different available vaccines.
"Many Covid-19 vaccines have been produced, but some may come from a country whose drug regulatory bodies are not recognised by others," he said.
He said some countries might not agree to admit people administered with vaccines they had not approved themselves.
Awang Bulgiba also said the system would disadvantage those from poorer countries whose governments were less equipped to procure vaccines.
"Most of the world's Covid-19 vaccine supplies have been bought up by developed and richer countries, leaving the poorer ones scrambling for the rest," he said.
"Until all nations are able to vaccinate their populations, a vaccine passport may be viewed as discriminatory and hinder the growth and recovery of poorer nations as their unvaccinated citizens may be prevented from travelling."
He also said the vaccines might not be effective against future viral mutations. Being inoculated, then, would not guarantee that a traveller would not contract an international variant and import it to his home country, especially since preventative standard operating procedures were not the same around the world.
He suggested instead that travel reciprocal bubbles be established between countries demonstrating herd immunity from vaccinations. These could be expanded to include more countries later on.
Chan agreed on all points and said that in addition to these concerns, it must be remembered that vaccinations might well continue past the initial rollout phase if future rounds of inoculation were needed.
"We also need to think about the equity implications of putting something like this in place," he said.
"People who tend to travel, be it for business or leisure, tend to be a bit more well off. If these people have influence on policy, it could make it harder for others to get access to the vaccine."
He said this could end up looking like a localised version of the vaccine race playing out globally, with richer people in the country able to buy vaccines in order to travel, leaving them less available for the underprivileged.
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How about a rail link?
I was disappointed last week that Andrew Mylius's article, 'Government gives green light to Shell Haven', failed to mention a rail link into the proposed container terminal at Shell Haven/London Gateway Port that is to become the largest in the UK.
The intended capacity of 3.5M TEUs a year equates to some 12,000 lorry movements per day every day throughout the year. Are we mad?
Good to see that the developer, Dubai Ports World, is 'generously' coughing up £1.25M to improve the A13.
What about a new railway to Birmingham?
This new container port, if it follows examples elsewhere around the world, will be an absolute goldmine for DP World. But see how lightly it is getting away with failing to meet sensible public obligations.


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Michael Zarin and David Cooper Publish Article in the NY Law Journal Questioning Government's Ability to Take Property to Build Border Wall
In the March 13, 2019 edition of the New York Law Journal's Eminent Domain column, Michael and David raise the question of whether a politically-motivated declaration of emergency could serve as a valid "public purpose" to permit the Government to take thousands of acres of private property along the Mexican border in light of the US Supreme Court's warning in Kelo v. City of New London against "pretextual" takings that do not serve a legitimate public purpose. While courts generally defer to findings of public purpose, Congress' rejection of the President's request for $5.7 billion in funding for the wall, and its rebuke of the declaration of a "national emergency," Michael and David opine that this may be one of those rare cases where the courts apply a higher level of scrutiny to a determination that taking private property would serve a public purpose.
See Michael D. Zarin & David J. Cooper, "Sufficient 'Public Purpose' to Take Property for Trump's Wall?," N.Y. Law Journal, March 13, 2019, at 5.


General Manager, Corporate Affairs, West Africa Gas Pipeline Company (WAGPC), Harriet Wereko-robby, says Ghana would soon begin payment of debt it owes on its gas supply agreement with NGas, a company owned By Nigerian National Petroleum Corporation, NNPC, Shell, and Chevron. Ghana's gas stands at $160 million, but the WAGPC administrator expects a payment of $30 million to be made 'shortly,' the Punch quotes her as saying.
General Manager, Corporate Affairs, West Africa Gas Pipeline Company (WAGPC), Harriet Wereko-robby, says Ghana would soon begin payment of debt it owes on its gas supply agreement with NGas, a company owned By Nigerian National Petroleum Corporation, NNPC, Shell, and Chevron.
Ghana's gas stands at $160 million, but the WAGPC administrator expects a payment of $30 million to be made 'shortly,' the Punch quotes her as saying.
Ghana and Nigeria reached an agreement for the supply of 127 million standard cubic feet of gas daily in 2011.
However, delivery volumes dropped due to pipeline vandalization by Niger Delta militants and debts owed by the Volta River Authority (VRA).
The Volta River Authority has set-up a payment security, which is expected to cover up the debt burden. The West Africa Gas Pipeline supplies gas to Togo and Benin Republic as well.


text:
Diese Episodenliste enthält alle Episoden der US-amerikanischen Fernsehserie Drei Engel für Charlie in der Reihenfolge ihrer Erstausstrahlung in den Vereinigten Staaten. Von 1976 bis 1981 entstanden in fünf Staffeln insgesamt 115 Episoden. Die Erstausstrahlung in den USA erfolgte durch ABC. In Deutschland strahlte das ZDF erstmals vom 14. April 1979 bis zum 14. Mai 1980 28 Episoden aus, vom 6. Oktober 1989 bis zum 30. November 1990 folgten 58 Episoden auf Sat.1. Vom 15. Juni 1992 bis zum 29. November 1993 sendete Kabel eins zwölf Episoden erstmalig in deutscher Sprache, vom 10. Januar bis zum 23. Januar 1995 kamen neun Episoden auf ProSieben hinzu. Die restlichen acht Episoden von Drei Engel für Charlie wurden bislang nicht berücksichtigt.

Staffel 1

Staffel 2

Staffel 3

Staffel 4

Staffel 5

Weblinks

Episodenliste

redpajama_set_name: RedPajamaWikipedia


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text:
A Guide to the Everett Andrew Hanson
Creator: Hanson, Everett Andrew, 1919-2006
Title: Hanson, Everett Andrew, Papers
Abstract: The Everett Andrew Hanson Papers, 1942-1945, comprise newspapers and newsletters, photographs, and Nazi souvenir postcards documenting Hanson's service in the U.S. Army during the Second World War.
Extent: 1 ft.
A native of Kemah, Texas, Everett Andrew Hanson, Jr. (1921-2006), served with the U.S. Army's 305th Engineer Battalion and in France, Belgium, Germany, Luxembourg, and Austria during World War II. He supervised estimates on the work and manpower necessary to complete bridges and navigate obstacles. Additionally, Hanson helped determine the best routes for infantry units to enter difficult terrain as well as assessed water supplies and road conditions. For his service, Hanson received the Normandy Medal, American Campaign Medal, World War II Victory Medal, Good Conduct Medal, and the European-African-Middle Eastern Campaign Medal along with four Bronze Stars.
The Everett Andrew Hanson Papers, 1942-1945, comprise newspapers and newsletters, photographs, and Nazi souvenir postcards documenting Hanson's service in the U.S. Army during the Second World War. The newspapers chronicle the end of World War II and include the Houston Press, Galveston Daily News, Stars and Stripes as well as Cardinal Chirps, a school newsletter from League City, Texas. Photographs depict Hanson and his colleagues. Additionally, souvenir postcards depict Hitler and his watercolors, among other subjects.
Hanson, Everett Andrew, 1919-2006 -- Archives
Hitler, Adolf, 1889-1945
United States. Army. Engineer Battalion, 305th
World War, 1939-1945 -- Germany
Everett Andrew Hanson Papers, 1942-1945, Dolph Briscoe Center for American History, The University of Texas at Austin.
This collection contains unprocessed materials.
Basic processing and cataloging of this collection was supported with funds from the National Historical Publications and Records Commission (NHPRC) for the Briscoe Center's History Revealed: Bringing Collections to Light project, 2009-2011.
Contact repository for inventory.


Oh my goodness! It's hard to believe now, that we almost sold this little beauty! She was reserved, but the buyer decided that she wasn't ready for another goat.
It didn't take long for me to realize - this girl needed to stay- and I have been so thankful it turned out that way!
I love Abilene's color! I'm not sure what color she will end up being- but like her mom, Annabelle, it will be unique!
Abilene also has her Mom's sweet, lovable disposition and is always looking for hugs and cuddles.
He gave her some height, straighter front legs, and a good bit of width in her escutcheon. We'll see what kind of udder he adds!


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Nakanoshima, ofta även Ama efter huvudorten) är en ö bland Okiöarna i sydvästra Japanska havet som tillhör Japan.

Geografi
Nakanoshima ligger cirka 60 kilometer utanför Japans huvudö Honshu.

Ön är av vulkaniskt ursprung och har en areal om ca 33,5 km². Den högsta höjden är Mount Kinkoji på cirka 164 m ö.h.

Befolkningen uppgår till ca 2 300 invånare fördelade på huvudorten Ama på öns norra del och de större byarna Hishi, Hinozu, Saki, Chichii, Nakazato och Toyoda.  Förvaltningsmässigt utgör hela ön tillsammans med kringliggande småöar som bl.a. Omorijima och Matsushima landskommunen Ama-chō (Ama köping) och tillhör Shimane prefektur.

Ön kan endast nås med fartyg då den saknar flygplats,, det finns regelbundna färjeförbindelse med hamnstäderna Sakaiminato och Shichirui på fastlandet.

Historia
Det är osäkert när Okiöarna upptäcktes men de har varit bebodda sedan flera tusen år och omnämns redan i böckerna Kojiki och Nihonshoki.

Redan under Naraperioden på 700-talet användes öarna som exilort.  I slutet på 700-talet skickades år 794 den lärde Onono Takamura i exil på Nakanoshima och kejsare (tennō) Go-Toba dog i exil på ön år 1239.  1939 byggdes Oki shrine till minnet av kejsaren.

Sedan Kamakuraperioden i slutet på 1100-talet förvaltades området som "Oki no kuni" (Oki-provins) av en shugo (guvernör) från Izumoprovinsen.

Från Ashikagaperioden i mitten på 1300-talet och fram till Sengokuperioden i slutet på 1500-talet styrdes området av olika klaner.

Under Edoperioden tog Tokugawaklanen makten och området underställdes Shogunen. Öarna var under denna tid mellanlandningsplats för handelsfartyg till övriga Asien.

1871 blir öarna först del i Tottori prefekturen och övergår 1881 till Shimane prefekturen.

Källor

Externa länkar
 Om Nakanoshima/Ama
 Karta över Nakanoshima/Ama

Japans öar
WP:Projekt Japan


Let's face it….life is not easy. Things fall apart….people get sick, Financial struggles arise….people are not perfect. When we rely on ourselves..or on other people….we are going to get disappointed. It is only when we remember to keep our eyes on the Lord that life's trials wont drown us. When Peter stepped out of the boat, he was able to walk on the water as long as he kept his eyes on Jesus. The second he focused on the water, and took his eyes off Jesus and began to doubt, he started to sink .
All too often we let the storms of life take our focus off of Jesus, we start to stress and worry, and begin to sink. Feelings of failure, and doubt fill our minds…and we say " I cant do this alone" " I give up" …..and we are right, we CANT do it alone….we need to look to God for help. whether its finances, or health, or other issues….without God we are just fighting to hold onto pride, and do things on our own.
The Bible tells us in many places that we should not worry, but Cast our cares upon the Lord, for He cares for us. ( Luke 12:22-34….1 Peter 5:7… just to name a couple) I am writing this just as much for myself as anyone. I have seen first hand numerous times how God provides for his children when we let go and turn our cares over to Him. I also know that prayer is not a big bandaid and sometimes we DO struggle, and the answer to prayer is not always what we WANT…but God is in control, and HE knows what is best. All we have to do is stop relying on our own strength and turn it over to Him. He has promised He will never give us more than He knows we can handle…and He is NOT gonna leave us in the midst of a crisis to struggle alone…..He will provide a way out….and will be there with us in the Midst of it…IF we let Him. Psalm 23: 4 states "Even though I walk through the valley of the shadow of death, I will fear no evil, for you are with me; your rod and your staff, they comfort me." This is usually read at funerals…however, it is meant for everyday life…..yes we will have trials and hardship….but Through those dark times, God is with us…He does not leave us. He did not keep Daniel out of the Lions Den….but was there with him …and kept him safe from the Lions, and in the outcome, God got the glory, because Daniel held onto his faith that God would protect him. (Daniel 6). God did not keep Shadrach, Meshach and Abednego out of the fire…but he met them there…and they walked out unburned..because of their faith, and God got the glory (Daniel 3).
Posted on May 12, 2010 by RachelB	• This entry was posted in Faith, Family, Prayer and tagged Faith, Family, Prayer. Bookmark the permalink.


text:
Biochemistry. 2016 May 24;55(20):2883-97. doi: 10.1021/acs.biochem.6b00022. Epub 2016 May 13.
Structural and Functional Investigation of the Ag(+)/Cu(+) Binding Domains of the Periplasmic Adaptor Protein SilB from Cupriavidus metallidurans CH34.
Urbina P1, Bersch B2, De Angelis F1, Derfoufi KM1, Prévost M1, Goormaghtigh E1, Vandenbussche G1.
Laboratory for the Structure and Function of Biological Membranes, Center for Structural Biology and Bioinformatics, Université Libre de Bruxelles , B-1050 Bruxelles, Belgium.
Institut de Biologie Structurale (IBS), Univ. Grenoble Alpes, CEA, CNRS , 38044 Grenoble, France.
Silver ion resistance in bacteria mainly relies on efflux systems, and notably on tripartite efflux complexes involving a transporter from the resistance-nodulation-cell division (RND) superfamily, such as the SilCBA system from Cupriavidus metallidurans CH34. The periplasmic adaptor protein SilB hosts two specific metal coordination sites, located in the N-terminal and C-terminal domains, respectively, that are believed to play a different role in the efflux mechanism and the trafficking of metal ions from the periplasm to the RND transporter. On the basis of the known domain structure of periplasmic adaptor proteins, we designed different protein constructs derived from SilB domains with either one or two metal binding sites per protein chain. ITC data acquired on proteins with single metal sites suggest a slightly higher affinity of Ag(+) for the N-terminal metal site, compared to that for the C-terminal one. Remarkably, via the study of a protein construct featuring both metal sites, nuclear magnetic resonance (NMR) and fluorescence spectroscopies concordantly show that the C-terminal site is saturated prior to the N-terminal one. The C-terminal binding site is supposed to transfer the metal ions to the RND protein, while the transport driven by this latter is activated upon binding of the metal ion to the N-terminal site. Our results suggest that the filling of the C-terminal metal site is a key prerequisite for preventing futile activation of the transport system. Exhaustive NMR studies reveal for the first time the structure and dynamics of the functionally important N-terminal domain connected to the membrane proximal domain as well as of its Ag(+) binding site.
10.1021/acs.biochem.6b00022
Carrier Proteins/chemistry*
Carrier Proteins/metabolism
Cupriavidus/chemistry*
Cupriavidus/metabolism
Ion Transport
Periplasm/chemistry*
Periplasm/metabolism
Periplasmic Proteins/chemistry*
Periplasmic Proteins/metabolism
Protein Domains
Silver/chemistry*
Silver/metabolism
Spectrometry, Fluorescence
Periplasmic Proteins


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