1) A foglalható szobák megtekintéséhez ezen a településen: Destin adja meg az érkezés és távozás dátumát és kattintson a KERESÉS gombra.
2) Válassza ki a kívánt szobát itt: ezen a településen: Destin, majd adja meg a szobák számát kiválasztva a legördülő mezőben és kattintson a kék színű gombra: "FOGLALÁS".
Tipp: amennyiben finomítani szeretné a keresét, mint szállástípus, kategória, szolgáltatások, stb. használja a bal oldalon található Keresés finomítása lehetőséget itt: Destin bejelölve a preferanciákat. Válasszon panziót, apartmant, szállodát ezen a helyen: Destin. Tartózkodását kellemessé tehetei a jakuzzi, klímaberendezés, WiFi, autó- vagy kerékpár bérlés, stb.
This pet-friendly hotel offers an outdoor pool, a hot tub, and complimentary breakfast. Accommodations are provided with fully equipped kitchens and free high-speed Internet. Topsail Hill Preserve State Park is 5.3 km away. Residence Inn Sandestin offers suites and studios with living and dining areas. Kitchens come with stove-tops and refrigerators. Tea- and coffee-making facilities are also provided. Guests at this Grand Boulevard hotel can work out at the fitness centre which features cardio equipment and a weight machine. A sports court is also on site. A social hour with snacks is offered on select weeknights. The Northwest Florida Regional Airport is 64.4 km away. Shopping and dining at Boulevard 10 is a 7 minutes' walk away.
This Destin, Florida hotel is located across the street from the beach and provides an outdoor pool and a complimentary made-to-order breakfast daily. Silver Sands Premium Outlets is 14 minutes' walk away. A flat-screen cable TV and a desk are provided in every room at this Destin Miramar Beach Embassy Suites. Extra amenities include a safety deposit box and free toiletries. A fitness centre, business centre, and meeting facilities are on site. Free parking is provided on site at Embassy Suites Destin Miramar Beach as well. Destin Commons restaurants and shops are 8 minutes' drive away. The hotel is also within 10.6 km of Henderson Beach State Park and 3 golf courses. Calypso Café offers modern American cuisine with hand-crafted cocktails. Complimentary light snacks, beer, and wine are served at the nightly evening reception.
This Miramar Beach, Florida-area Courtyard by Marriott Sandestin at Grand Boulevard is located off Highway 98 and is 2.2 km from Topsail Hill Preserve State Park. Feature include free WiFi, an outdoor pool, and rooms with a flat-screen TV. All rooms offer contemporary furnishings including a seating area, a spacious work desk, and a coffee machine. Guest can relax at the poolside hot tub or venture out along running and walking trails. The hotel fitness centre has cardio equipment, and meeting rooms are available for a fee. The Bistro serves healthy food options and is open for a hot breakfast and dinner every day. Lunch is available on a seasonal basis. Guests can enjoy a daily newspaper as well. Destin beach is 5 minutes' drive by car, while Santa Rosa Golf & Beach Club is 9.2 km away from the hotel. Guests will also be 1.2 km from Baytowne Marina.
All apartments have a balcony at this Miramar Beach Ariel Dunes By Wyndham Vacation Rentals. On-site features include an outdoor pool and a tennis court. A kitchen, separate seating area, and a cable TV are standard in each spacious apartment. Some Ariel Dunes By Wyndham Vacation Rentals apartments have a coastline view. A fully equipped fitness centre and a launderette are available to all guests throughout their stay. A full-service bar, restaurant, and quick service café are on site as well. An array of activities can be enjoyed on site or in the surroundings, including golfing and fishing. Fort Walton Beach Airport is 33.6 km from Ariel Dunes By Wyndham Vacation Rentals.
Nestled on the stunning grounds of the Resort at Sandestin, within one mile (1.6 km) of the sandy beaches of the Gulf of Mexico, this property in Destin, Florida offers relaxing amenities. Bay Club of Sandestin is surrounded by world-class shopping, beautiful sunsets and historic sites. Guests can go fishing, spend the day at the beach or explore Destin city centre. Guests at the Sandestin Bay Club will enjoy easy access to golf, tennis and a marina. After swimming or working out in the fitness centre, guests can choose from 14 restaurants to dine in.
Fairfield Inn & Suites by Marriott Destin is a 3 minutes' walk from Henderson Beach State Park. Guests can start their day with a complimentary breakfast and then take a dip in the indoor or outdoor pools. Complimentary WiFi is provided for all guests. Rooms feature a flat-screen TV with cable channels. A refrigerator, coffee maker, and microwave are provided as well. Select rooms offer a balcony and seating space. A 24-hour front desk is available for guests' convenience. Guests can also use the on-site fitness centre, sun terrace, and laundry facilities in addition to a vending machine with drinks. Big Kahuna's water park is 2.6 km from Fairfield Inn & Suites by Marriott Destin. Kelly Plantation Golf Club is located 5 minutes' drive from the hotel.
Holiday Inn Express Destin E - Commons Mall Area is located 7.2 km from downtown Destin, Florida. Guests can start their day with a complimentary continental breakfast, and then take a refreshing plunge in the outdoor pool. Complimentary WiFi is available to all guests. Rooms feature a flat-screen TV. Guests will enjoy the convenience of a microwave and a small refrigerator. Business guests can get to work in the business centre. The hotel's front desk is staffed 24 hours a day. Free daily newspapers are provided. The Destin Commons is a 5 minutes' drive from the Holiday Inn Express Destin E - Commons Mall Area. The Destin-Ft. Walton Beach Airport is a 7-minutes' drive away.
Located on Miramar Beach, this Sandestin golf and full-service spa resort features 15 tennis courts and 3 swimming pools. Free WiFi is provided in all rooms. Big Kahuna's Water Park is 17 minutes' drive away. A flat-screen cable TV with pay-per-view channels and a desk are featured in every room at Hilton Sandestin Beach Golf Resort and Spa. Extras include free toiletries, towels, and linen. A games room, shops, and launderette are available for guest use at this Destin Hilton Sandestin Beach Golf Resort and Spa. Paddleboards, kayaks, and organised children's activities are available as well. Five restaurants are on site, which includes Seagar's Prime Steaks and Seafood and Hadashi Sushi Bar. A mini-market, full-service bar, and coffee shop are offered as well. Guests will also be 6 minutes' drive from shopping at Village at Baytowne Wharf and 13.8 km from Henderson Beach State Park.
The Beach House Condominiums are located on the shores of Miramar Beach, just 7.5 miles from the Big Kahuna theme park. Guests will enjoy a fully-equipped kitchen in each unit. Free Wi-Fi is included in each apartment of these Miramar Beach holiday rentals. A TV and DVD player are also provided in every unit along with a private balcony for added comfort. An outdoor pool and children's pool can be accessed by guests of the ResortQuest Beach House Condominiums. Barbecue facilities are also available and DVD rental is possible on site. This property is less than 30 minutes' drive from Florida's Gulfarium and 1 mile from the Silver Sands Factory Stores. Henderson Beach State Park is 6 miles away.
Az állatbarát Destin, FL szálloda minden lakosztálya felszerelt konyhával és 81 cm-es síkképernyős TV-vel rendelkezik. A Miramar strand 1,4 km-re található. A Destin Candlewood lakosztályai ingyenes wifivel és íróasztallal várják a vendégeket. DVD-lejátszók és ingyenes helyi hívások is rendelkezésre állnak. A Candlewood Suites Destin-Sandestin Area szabadtéri medencével és fitneszközponttal is rendelkezik. A szálláshelyen üzleti központ, valamint ingyenes film és CD könyvtár is rendelkezésre áll. A vendégek az ingyenes mosási lehetőséget is igénybe vehetik, vagy harapnivalókat vásárolhatnak a kisboltban. A Big Kahuna's vízi park 10,8 km-re található a szálláshelytől. A Topsail Hill Preserve Állami Park 9,5 km-re található.
This hotel is located in Destin, Florida and is 12 minutes' drive from Gulfarium Marine Adventure Park. The hotel offers an outdoor pool, fitness centre, and rooms with free WiFi. A microwave and refrigerator come standard in each room at Wingate by Wyndham Destin. The rooms are also equipped with a work desk. Guests can enjoy a daily continental breakfast at the Wyndham Destin Wingate. The hotel also offers meeting facilities too. Destin Harbor is 3.2 km from this hotel and features entertainment and dining. The hotel is 11.3 km from the Emerald Coast Conference Center.
Offering a private beach along Florida's Emerald Coast, SunDestin offers spacious apartments with free WiFi .It has an indoor and outdoor swimming pool with a hot tub. A kitchen with a dishwasher, microwave, and stove is in SunDestin's air-conditioned apartments. Each comes with a bright décor and a living room including a sofa bed and cable TV with DVD player. All come with a bathroom and a guest toilet. SunDestin Beach has a spa on site. Guests can also work out in the fitness centre. A coin-operated laundry facility is available on each floor. Silver Sands Factory Stores is 4 miles from the resort, and Destin - Fort Walton Beach Airport is 30 minutes' drive away. Free parking is available at SunDestin Beach.
Big Kahuna's Water Park is a 4-minute drive from this Destin, Florida hotel. The hotel features an outdoor pool and classic guest rooms with cable TV including the HBO channel. Decorated with dark wood furniture, each room includes a microwave and refrigerator. Destin Inn & Suites offers free local telephone calls in every room. Laundry facilities and a 24-hour front desk are available. Gator Beach is a 10-minute drive from Destin Inn. Henderson Beach State Park is 3.4 miles away.
Village Inn Destin is located in Destin, FL. The property is 1.1 km from Destin Harbor. Guests can enjoy the outdoor swimming pool. This hotel's rooms features a microwave, refrigerator, and free WiFi. The Village Inn Destin offers a daily breakfast, which includes waffles. The hotel also offers laundry facilities. Additional guestroom amenities include on-site business services and free local calls. Free parking is provided. The shops and restaurants of Harborwalk Village are 550 metres from the accommodation. The Destin Village Inn is 5.9 km from Henderson Beach State Park. The Destin Fort Walton Beach Airport is 25.1 km from the hotel.
This Destin, Florida hotel offers a a small, man-made harbour beach and is located on Destin Harbor. Features include a waterfront pool with a panoramic harbour view, and Henderson Beach State Park is 6 km away. Destin Harbor Boardwalk is a 1 minute drive away. A balcony, free WiFi, and flat-screen cable TV are featured in every room. A microwave and refrigerator are provided as well. The Inn on Destin Harbor also offers coffee facilities. City views or harbour-front rooms are available. A pool is available of guests to enjoy. The property also has free parking is provided on site. Fort Walton Beach is 13.44 km from the Harbor Inn on Destin. Eglin Air Force Base is 18.2 km away. The Destin Boardwalk, which is lined with restaurants and boat docks, is 1.6 km from the property.
The Motel 6 Destin is less than 10 miles from Fort Walton Beach and 5 minutes' drive from Henderson Beach State Recreation Area. The hotel has an outdoor pool on site. Cable TV is included in every simply decorated guest room of this Destin hotel. Bedding features bright coloured patterns and free Wi-Fi is available. A laundrette is on site at the Destin Motel 6 and guests will also enjoy free morning coffee at the reception. Fax and photocopying facilities are available. Eglin Air Force Base is 15 miles from this hotel and Point Washington State Forest is 30 minutes' drive away. The Indian Bayou Gold Club is 3 miles away.
Days Inn by Wyndham Destin is 2.3 km from Henderson Beach State Park. It features an outdoor pool with a sun deck and provides free Wi-Fi in every room. Cable TV with HBO is offered in the spacious, traditionally decorated rooms at Days Inn by Wyndham Destin. They are also equipped with a coffee maker, hairdryer, and ironing facilities. Guests can enjoy a daily continental breakfast during their stay at this pet-friendly hotel. Vending machines with snacks and drinks are available. Located on Highway 98, Destin Days Inn by Wyndham is just a 7-minutes' walk from Big Kahuna's Water Park. Destin Harbor is 1.6 km away.
This hotel is on Miramar Beach and is less than 6 miles from Indian Bayou Golf Club. Guests staying at Crystal Villas by Wyndham Vacation Rentals can enjoy free WiFi throughout their stay. All accommodations feature a fully equipped kitchen and a balcony. Crystal Villas by Wyndham Vacation Rentals also includes a seating area with a sofa, dining area, and in-suite launderette. Resort guests can rent videos for a quiet night in their room or take a stroll on the nearby beaches of the Gulf of Mexico. Free parking is provided for added convenience. The resort is 1.6 km from Florida's Gulfarium and 3.2 km from Silver Sands Factory Stores. Big Kahuna Water and Adventure Park is 10 minutes' drive away.
A Travelport.cz ajánja Önnek ebben a városban (Destin) a szállásfoglalást anélkül, hogy azonnal, online kellene fizetnie.. A tartózkodás árát a szálloda recepcióján fogja kiegyenlíteni.
Hasonlítsa össze a szállodai kínálatot ebben a városban: Destin.
Válassza ki magának a legmegfelelőbb szállodát ebben a városban: Destin, majd tekintse meg a térképen annak elhelyezkedését, olvassa el a hozzá tartozó információkat és tekintse meg a rendelkezésre álló fotókat.


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Miko Mayama (* 15. August 1939 in den Vereinigten Staaten) ist eine US-amerikanische Schauspielerin.

Leben
Mayama betätigte sich ab Mitte der 1960er bis Ende der 1970er Jahre als Film- und Fernsehschauspielerin. Sie hatte dabei einige Gastauftritte in Serien, wie etwa in Valentine's Day (1965), Tennisschläger und Kanonen (1966), als Yeoman Tamura in Raumschiff Enterprise (1967), Ihr Auftritt, Al Mundy (1968), als Miko in The Beverly Hillbillies (1971), Der Chef (1971), Medical Center (1971–1972), Hawaii Fünf-Null (1972), Kojak – Einsatz in Manhattan (1974), Mannix (1974) und M*A*S*H (1979).

Filme in denen sie spielte sind unter anderem Gokudō Bōzu: Nenbutsu Hitokiri Tabi (1969), Auf der Jagd nach dem verlorenen Gold (1969), Herrscher der Insel (1970), Amanda Fallon (1973), Jefferson Bolt – Reisender in Dynamit (1973) und Cage Without a Key (1975).

Filmografie
 1965: Valentine's Day (Fernsehserie, eine Folge)
 1965: Wendy and Me (Fernsehserie, eine Folge)
 1965: Boeing-Boeing
 1966: Tennisschläger und Kanonen (I Spy, Fernsehserie, eine Folge)
 1966: Nicht so schnell, mein Junge (Walk Don't Run)
 1966: Hey, Landlord (Fernsehserie)
 1967: F Troop (Fernsehserie, eine Folge)
 1967: Raumschiff Enterprise (Star Trek, Fernsehserie, eine Folge)
 1967: Die Gewaltigen (The War Wagon)
 1968: Ihr Auftritt, Al Mundy (It Takes a Thief, Fernsehserie, eine Folge)
 1969: Gokudō Bōzu: Nenbutsu Hitokiri Tabi
 1969: Auf der Jagd nach dem verlorenen Gold (Impasse)
 1969: Love, American Style (Fernsehserie, eine Folge)
 1969: Eddies Vater (The Courtship of Eddie's Father, Fernsehserie, eine Folge)
 1970: The Flying Nun (Fernsehserie, eine Folge)
 1970: Herrscher der Insel (The Hawaiians)
 1970: Matt Lincoln (Fernsehserie, eine Folge)
 1971: To Rome with Love (Fernsehserie, eine Folge)
 1971: The Beverly Hillbillies (Fernsehserie, drei Folgen)
 1971: Der Chef (Ironside, Fernsehserie, eine Folge)
 1971–1972: Medical Center (Fernsehserie, zwei Folgen)
 1972: Hawaii Fünf-Null (Hawaii Five-O, Fernsehserie, eine Folge)
 1973: The Bold Ones: The New Doctors (Fernsehserie, eine Folge)
 1973: Amanda Fallon (Fernsehfilm)
 1973: Jefferson Bolt – Reisender in Dynamit (That Man Bolt)
 1974: Kojak – Einsatz in Manhattan (Kojak, Fernsehserie, eine Folge)
 1974: Mannix (Fernsehserie, eine Folge)
 1975: Cage Without a Key (Fernsehfilm)
 1979: M*A*S*H (Fernsehserie, Folge 7x18)

Weblinks

 Miko Mayama bei memory-alpha.org (ein Star Trek wiki) (englisch)

Filmschauspieler
US-Amerikaner
Geboren 1939
Frau

redpajama_set_name: RedPajamaWikipedia


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Kottayam is a multi-religious city with Hinduism, Christianity and Islam being followed most prominently. Reflecting the religious culture of the place, the city is wide-spread with temples, churches and mosques. This region also boasts about the most beautiful and intricate temples of India.
Temples in Kottayam
Most temples were built under the patronage of various Hindu kings during the 2nd Millenium.
Thirunakkara Sree Mahadeva temple
Thirunakkara Sree Mahadeva Temple depicts various themes from various epics. The temple is located in the centre of the city and is built in traditional Kerala architectural style.
Ettumanoor Mahadev Temple
The "Aghora Moorty" of the temple has a special place for devotees from south India. According to legend a great saint "Khara Prakasha" invoked Lord Shiva to wash off his sins and help him worship the Lord for future generations. Lord Shiva in his gratitude presented him with his idol which the saint installed at this place facing the West. As per Hindu legend "Aghora" is the intense and grave form of Shiva. This shivlinga was long forgotten and became part of a dense forest where a Harijan woman found it while collecting arrow roots with her sickle. The sickle struck the stone which began bleeding and till today certain ridge marks on the linga are believed to be those sickle marks.
The temple has awe-inspiring features such as the idols of seven large elephants and baby elephant made out of solid gold. These were gifted by Mahaharaja Karthika Thirunal to the temple. They are brought out for public display on the 8th and 10th of February/March annual festival. This is a major attraction for the devotees each year.
Address: Ettumanoor Temple Rd, Kerala- 686631
Dakshina Mookaambika
This is one of the temples dedicated to Goddess Saraswati among the many other dedicated to Lord Shiva. It is located in the Panachikuda village of Kottayam, some 11 kms (7 miles) away from the main headquarter district. Unlike most Saraswati temples which allow pooja only during "Navratri" this temples offers pooja throughout the year.
Address: North Paravoor, Kerala
Kumaranalloor Devi Temple
This is a temple dedicated to Goddess Bhagwati - one of the most worshipped deities in Kerala. The shrine is located 4 kms (2.5 miles) away from Kottayam. The deity is worshipped in five different forms. This temple is considered as powerful as Meenakshi Temple in Madurai, Tamil Nadu. The temple has very unique architecture as well which are built in what is called the sreechakra style. The architecture is considered rare even for Indian temples.
Address: Kumaranalloor, Kottayam - 686016
Churches in Kottayam
Kottayam is a major place for Syrian Christians where the Christianity was wide-spread and is still sustained.
Malankara Orthodox Syrian Church
It is one of the most sacred churches in Kerala also called as the Indian Orthodox Church. The church falls under Saint Thomas Community of India and has its origins in the Thomas the Apostle's activity. It is an ancient church and originated in A.D 52 under St. Thomas – one of the disciples of Jesus Christ. They came to India and preached Christianity in the south-western part of India.
Kottayam Big Church
Also known as Kottayam Valiya Palli of Knanaya Community, it was built in 1550 by Syrian Christians who migrated from Kaduthuruthy and is the first Christian Church in Kottayam. The church is worth a visit for big ancient murals and antique carvings on the ceiling and behind the altar. It also holds two granite Persian Crosses.
Syro-Malabar Catholic Church
This church is listed as the second largest Eastern Catholic Church under Rome. This is one of 22 only listed churches. The church is of apostolic origin believing in St. Thomas who is known to have landed in Kerala and who founded seven Christian communities here. They are also known as Nazarenes i.e those who follow the path of Jesus of Nazareth. The church and its followers also have a strong Portuguese influence.
There is a St. Thomas Christian Museum at Mt. St. Thomas Kakkanad and has a strong collection of Christian history, artistic objects, palm leaves manuscripts, household items, coins, stamps and liturgical objects.
The church also has murals of missionary activities of St. Thomas and also conducts exhibitions of various artists. It has a light and sound show on the important events in St. Thomas' life.
Kaduthuruthy Church
The Syro-Malabar Cathlolic Church has a parish in Kaduthuruthy a town in Kottayam district. The church is also known as St. Mary's Forane Church.
Address: Valiyapally Rd, Kaduthuruthi, Kerala 686604
St. George's Knanaya Catholic Church
The Syro-Malabar Cathlolic Church has a parish in Edackat a town in Kottayam district. The church is also known as St. George's Knanaya Catholic Forane Church.
Address: St.George's Forane Church, Edackat, Kottayam-686 001
St Mary's Jacobite Syrian Church
The origin of this church dates back to early Christianity. It recognizes the Syrian Orthodox patriarch of Antioch as its spiritual head. The foundation goes back to Apostolic days. The faith and liturgy is very similar to the Universal Syrian Orthodox Church as above. This faith recognises the Mother of Jesus as Mother of God and worship her with greater faith.
Address: St. Mary's Jacobite SyrianOrthodox Church-Neelimangalam, Perumpaickad.P.O, Kottayam, Kerala - 686028
Mosques in Kottayam
Similar to temples and churches, the mosques in Kottayam have a rich history and their own festivals to celebrate the holy months.
Thazhathangady Juma Masjid
This is one of the most revered and ancient mosques in Kottayam. It is believed to be 1000 years old. The mosque is built with an inner courtyard and a traditional bathing area. There is also latticed window work on the inside. The temple is located on the banks of the river Meenachil. It is also known as the Taj Juma Masjid.
Comments / Discussion Board - Religious Spots in Kottayam

redpajama_set_name: RedPajamaCommonCrawl


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Q: How to associate existing autoscaling group to elastic beanstalk environment? I have a python web application which I need to deploy on AWS. But when I try to create an environment the beanstalk wizard tries to create a new security group, launch configuration and autoscaling group. My problem is I don't have rights to create new security group and I was provided with pre configured security groups, autoscaling groups and launch configuration by someone else. The launch configuration is created by copying the launch configuration created by Beanstalk wizard if the beanstalk wizard was allowed to create the security groups and all. So it does have all the bootstrapping code. How do I create a BeanStalk environment which will use the existing Autoscaling and security groups ? I don't see any option for that on the UI Wizard. I also couldn't find if its possible to achieve by .ebextensions.

A: Elastic Beanstalk uses AWS CloudFormation to manage the resources it uses. CloudFormation cannot use existing resources.
The Auto Scaling group, security groups, etc. must be created by Elastic Beanstalk.
You will need to go back to your IT team (that provided those resources) and work the permission issues out. Or don't use EB.

redpajama_set_name: RedPajamaStackExchange


This limited edition print depicts a mother and baby donkey painted in the New Forest. I enjoyed taking my sketch book to Hatchet pond, Beaulieu where many adorable donkeys gather. I used layers of acrylic paint to build up the fur and to create the colourful textured effect.


text:
History & Future
Communities & Networks
Communication Leadership
Earning the Degree
Career Directions
Careers & Networking
The perfect pitch opens ears at Starbucks
The secret of a good marketing pitch is great storytelling. If you have a story that touches the heart of your audience, it will work wonders. The Communication Leadership Program at the University of Washington has been instilling this power of storytelling skills in its students for over two decades now, and we've seen our students become the voice of some of the biggest organizations after graduating.
But recently, we witnessed something extraordinary. Two students, Aparna Jairaj, Cohort 21 – MCDM track, and Phuong Nguyen, Cohort 20 – MCCN track, curated a campaign for Starbucks as their final project in the Multicultural Marketing class in Spring 2022 taught by Ha Na Teresa Park. The campaign was so well thought out that Ha Na decided to connect the students to the Starbucks team, and before they knew it, they were presenting it in front of a panel of Starbucks leaders.
The campaign was curated for Hispanic heritage month and aimed at celebrating the Latinx culture. It was named #LetsGoToEStarbucks, and would be launched on the social media platform TikTok, to help strengthen the brand's connection with Latinx millennials in the U.S. by investing and nurturing relationships with this fast-growing group of consumers.
The concept concentrated on nine Latinx TikTok creators creating a customized Starbucks drink that reminds them of their childhood, and then ordering and sharing that drink with someone they love. The call to action is for their followers to follow suit in trying the drink and co-creating "that first sip" content. The objective of the campaign was to garner 100K TikTok user-generated content (UGC) posts using #LetsGoToEstarbucks during the 2022 Hispanic Heritage Month.
Aparna and Phuong got to share this idea in front of three Starbucks teams – Loyalty, Social Media, and Paid Media. The idea and the strategy behind #LetsGoToEStarbucks were widely appreciated. Aparna and Phuong were praised for their captivating storytelling skills and dedication to creating something outside-the-box that could speak to the customers in a personal way.
Aparna and Phuong say they chose Starbucks as their client for the class because of the leadership qualities of responsibility, advocacy, and community that they had in common with the coffee giant. They also spoke about how communicating with the community is a big part of any brand's values, which is what led them to highlight the importance of cultural pride, and the experience of being a woman in their campaign.
According to the students, their instructor Ha Na was a constant force of motivation and support during the development of this campaign. She tutored Aparna and Phuong about the importance of inclusion and diversity, and gave crucial lessons about how to practice it in real life while presenting. Ha Na went above and beyond to ensure her students portray the story and emotions behind the campaign in the most creative and impactful manner possible.
The Communication Leadership graduate program at the University of Washington has always focused on finding ways to provide students with the chance to experience the real world even before they graduate. While Aparna and Phuong got to experience it through Ha Na's class, our other students work with many Seattle local organizations under Communication Leadership Consulting, and others take practicum classes to learn how to handle a client and a project from start to finish.
Applications are open through February 1st for Autumn 2023 start. Find more information here.
Comm Lead Open House 2022
Comm Lead Student Ambassador Q&A
commlead@uw.edu
4101 E Stevens Way NE, Seattle, WA
Subscribe to our newsletter for admissions info, events, and the latest trends in professional communication.
© Copyright 2022 Department of Communication. University of Washington


As part of our Ello Artist Series Pins contest we chose 4 different entries to be made into a mini Strange Ways Capsule Collection. The winning artwork was produced into pins to be sold exclusively at Strange Ways.
This winning design features the work of Matt Hanns Schroeter.


Next Preseason game Saturday, August 26 vs Indianapolis Colts 7:30 P.M.
Is there somewhere out there that ranks NFL teams schedules? If not, then I'll tell you right now the Steelers definitely have a favorable schedule, on the easier, per se. Ending and opening the season up with Cleveland are two sure wins. Then the next eight weeks they play two teams that pose a threat, Kansas City, and Baltimore, which are still possible wins. After their bye week, they face the Packers and Patriots, only two threats on their whole schedule. But it's no surprise the Steelers have a chance to win 12 games and a minimum of 10 games next season.
With an offense led by big-old, battered up Big Ben Roethlisberger, the Steelers look to again make a deep playoff run. Roethlisberger, despite being 35-years-old and out of his "prime" continues to be the backbone to this teams success. With a ton of depth at the wide out position, on top Antonio Brown and Le'Veon Bell star power. These two are top players in the NFL, it can't hurt to have them both causing headaches for opposing defenses throughout the season. The Steelers always play a consistent defensive game also(great fantasy defense option if you need a consistent 5-8 points a week), with a defense led by Stephen Tuitt on the offensive line, and a linebacker core of Ryan Shazier and James Harrison, and a secondary of Sean Davis, the defense supports the offense quite well. The Steelers only managed to give up 68 rushing yards per game, ranking 4th among NFL teams(2016).
WATCH OUT FOR Martavis Bryant, after his suspension is up Bryant will more than likely serve a WR2 option, and Bryant has shown some great strides this preseason and hopes to make an impact after serving his suspension.
WATCH OUT FOR Sammie Coates, with Bryant suspended, Coates will be an undervalued WR for Steelers. Coates can still fly and be a solid WR2/WR3 option while Bryant is out.
WATCH OUT FOR Artie Burns: Burns had 52 total tackles, 3 interceptions during his first year with Pittsburgh, with a ton of tools on this defense, Burns will be an emerging CB to keep an eye this season as he will be a big part of the Steelers defense.
San Jose fell short last season, after a 1st round, some new faces must be ready to answer the bell. Oh and Martin Jones is always there so San Jose won't have to worry much.
Calgary Flames fresh faces ready to make an immediate impact as the team shots for a 100-pt finish and deeper post season.


All times are in GMT -7 :: The time is now 10:55 pm.
Why was my e-mail account disabled?
Why was my e-mail account disabled for spam abuse?
How do I get my account back up if it was disabled for spamming?
The vast majority of the time when an e-mail account has been compromised and used to send spam those doing it harvested credentials through some type of malware or virus. In order to stop that we soft disable that email account(incoming mail to your account will still make it to our server) from an unaffected computer until you can scan with malware and virus scanners to clean the keylogger or whatever might be on your computer or device. It's impossible to know which device was used so it's important to scan them all (phones, desktop, laptop, tablet, etc). Scanners for mobile devices are available in the various app stores. It is a good practice to scan your computers occasionally even if you have no reason to suspect being compromised.
After downloading the software click "update" in each of them to make sure you have the latest threat detections. Then scan and "Fix." We recommend restarting the computer and scanning once more if you've received positive hits for the malware or etc. Once you've been able to scan your computer let us know and we'll give you a new password. You can either enter this new password into your mail clients or change it to something new that only you know via your account control panel. If you do this DO NOT change it back to the old password.


Make the mountains your next event destination for conferences, team building activities, incentives and motivational trips.
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George if you are using the 5965's it could be the tubes. For some reason the longer plate tubes tend to be slightly microphonic even though the construction is such that they should be more rugged.
Try a regular pair of 12AT7's/ECC81's (with smaller plates) and see if it still happens.
I admit George the 5965's can be a little troublesome, but because they sound so sweet I just use tube dampers and try not to "rap" on the chassis. The TFK 5965's do the same thing and I've had some 7062's do the same thing. All minor, but puzzling. The Raytheon 6414 3-mica black plates don't have the issue. All the above are long plate versions similar to each other construction-wise.
The only long plate tube I can't use becasuse the microphonics can't be tamed are the GE 5 Star 6829 3-mica. Still trying to figure a way to use those.
Thanks for the kind words--I'm just an amateur--folks like F1,Scomp, and Face are the big dogs.
Oops-- and FGTV--these guys know electronics/speakers,,I just try to follow their lead/advice.
Atleast you know where you stand, that's half the battle.
Hey George, how's the little Dared performing these days now that you have put some hours on the caps? Just curious if you are still as enamoured with it now as you were when you got it.
I might just hit you up for more tubes sir,,tell you the truth,I have not listened to it for awhile--I'll get my ears on it this weekend,,it will be going to PF with me.
George, how does the Dared compared to the wright?
Man,, good question,,,I've had to think about this one--the Dared is quicker than the Wright,,given the difference in tubes--I'd say the Wright has a wee tad more bloom,but not by much,,and that is based upon tube preference and the fact that I have nor done too much rolling in the Dared yet--really a very close call between the two,,of course,,that's just my rookie opinion.
I'll add my .02c, the Dared is very tube rolling friendly. I am amazed at the subtle differences I notice depending on what tube and rectifier combo I'm using.
Thanks George, I will be watching with great interest.
First of all,,a little entertainment--I was fortunate and got to see him and this band just recently,,here's a ten and a half minute taste.
Lets start with tubes. Currently running a Bendix 6106 rectifier and a pair of Sylvania 5965's I'm hoping that Brock,KiekoFGTV and others will chime in,as they have far more experience with tube rolling/schematics in this unit.I have the schematic's and can e-mail them to anyone who needs a set.First and foremost,this thread should be fun,and tube rolling is the easiest,but can get expensive.In the pic's you'll see where I remover the input caps,and replaced them with .22 400 volt Russian PIO(wrapped in black tape-IIRC the case is conductive)They are too big for the board,so I mounted them on the inside chassis,and ran wire from the board to the caps.I think a good cap in this position would be an Auricap and/or Sonicap and a good vintage PIO.
One thing that I noticed,,the Sylvania plates are offset.
Does the Dared SL-2000A have 4 .22uf caps? What is your take on Mundorf Supreme or Silver in Oil as replacement caps?
The sound of the Dared SL-2000A with the stock caps is already awesome, just by changing the stock tubes. I wonder if upgrading the caps would make much difference still.
You would have to mount the Mundorf's "outside" the unit as there is not much real estate inside.Obligatto's or Auricaps play nice with the unit,,and tube rolling in a stock unit will get you 90% of the way.
Thanks George. Are the 4 caps .22uf?
Don't forget how much the rectifier adds to the sound. The stock Chinese and Sovtek aren't that great at all. A Bendix 6106 or Brimar CV1863 (5Z4G equivalent) are superb with some of the older 5Y3's being a step up from the Chinese and Sovtek rectifiers.
The input caps (2) are 0.22uf and the output caps are (4) 1.0uf caps. The output caps have two caps per channel in series with a feedback connection between the first and second cap.
Which coupling caps are you talking about? Input or Output? George replaced both on his unit.
I was thinking of possibly using (4) of these for the output coupling caps replacing the (4) square yellow Carli 1uF 400v caps.
Anyone use these before, thoughts?
George if you still have the old yellow caps out would you mind doing a quick measure of them physically?
Both input and output caps. Might as well replace both.
Oh those yellow ones are output caps. Are they the stock caps? Are they good enough? Perhaps I'll just replace the input caps since they are not Auricaps. Replace these with Mundorf Supremes.
So are there two versions of this preamp?? A USA version??


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text:
Denuclearization of the Korean Peninsula: A Blessing for South Korean People
https://www.globalresearch.ca/denuclearization-of-the-korean-peninsula-a-blessing-for-south-korean-people/5643116
We have gone through, for the last three months, unusual experiences.
We could admire the humanism in sports; we were touched by the beauty, the elegance and the professionalism of North Korean singers and dancers.
We saw, through the Kim-Moon summit and the North-South exchange of musical groups, that the North-South blood tie was stronger than the North-South regime divide.
We were hoping with all our mind and heart for the closing of the last pages of the Cold War. But we realized that the Pyongyang Wall was pretty high.
We pray that the Singapore summit will make the Pyongyang Wall crumble, once and for all, as did the Berlin Wall.
We have been, for the last three month, hearing and reading, in connection with the nuclear issues, about governments, political leaders, diplomats and different events.
But, we seldom hear or read about the people who have been affected in different ways by the nuclear crisis.
Well, in this paper, I will discuss about how the South Korean people have been affected by the nuclear crisis.
To better understand the impact of the nuclear crisis on South Korea and its people, it is better to examine its internal political history.
In South Korea, there are two distinct groups in connection with the nuclear crisis. The one which has benefitted from the nuclear crisis is the conservative government and its supporters. The other one is the South Korean people for whom the nuclear crisis and North-South conflict were a heavy burden.
The principal negative impact of the nuclear crisis on the South Korean people includes the retreat of democracy, the increased Korea risk hurting foreign direct investments and the destruction of the groundwork of reunification.
My argument is that these heavy cost incurred by the South Korean People is attributable, mainly, to the dictatorship of the conservative government, which was facilitated by the Korean nuclear crisis and North-South tension.
On the other hand, as far as the conservative government and its supporters are concerned, the nuclear crisis has been very beneficial.
There are two reasons for this.
First, the nuclear crisis of North Korea has allowed the conservative government to scare the voters with frequent fabricated threats from the North and to get the votes in its favour. It has made itself elected many times owing to this unethical tactic.
Second, the nuclear crisis has given the conservative government ample opportunities to enrich, through illegal kickbacks, bribes and other illegal means, those individuals and the institutions involved in the production and the transactions of weapons.
Consequently, the denuclearization is a losing game as far as the conservative government and its supporters are concerned; they may even wish the Trump-Kim summit not to be successful.
To see this, we have to learn a few things from the Korean political history of the post-Pacific War era.
We will see how the conservative government has exploited the North-South conflict for its political ambition and financial greed.
When Korea was liberated from the yoke of Japanese colonialism in 1945, a conservative democratic government was established in the South under President, Syngman Rhee and a communist government, in the North under President, Kim Il-sung.
Thus, from the beginning of the post-Pacific War era, Korea was divided along the line of ideology. This was bad enough, but what was even worse was the division along the line of pro-Japan and anti-Japan positions.
The South Korean government was formed essentially by those who served the Japanese during the colonial era and who participated in the torturing of the Korean patriots and in many other crimes against Koreans, while the North Korean government was established by those who fought the Japanese armed forces.
In this way, the Korean peninsula was divided into pro-Japan democratic conservative group in the South and communist anti-Japan group in the North.
This double-line division of the Korean peninsula has created mutual mistrust, animosity and hostility. Under this situation, the conservative South Korean government and its supporters have developed "anti-North Korea culture" in which North Korea was demonized. North Korea was described as the eternal enemy of South Korea and a source of great danger.
Therefore, in the eyes of the conservative government, those who were sympathiser of North Korea were also enemies of South Korea, or more precisely, the enemy of the conservative government and its supporters.
The anti-North Korea culture made it easy for the conservative government to label all those who criticized it as "sympathizers of North Korea" and to punish them harshly in the name of the National Security Act.
All those who criticized the conservative government or who were not friendly to it were categorized as "Red".
The "Red-Culture", called in Korean language (Palgaing-ie-moon-hwa) emerged. Under the Red-Culture, even if you are pure democrat, you are a "Palgaing-ie", if you are not with the conservative government.
Under this situation, it was easy to impose dictatorship. In fact, all the conservative governments since 1948 were ruled by dictators.
President Syngman Rhee (1948-1960) had the most aggressive anti-North Korea attitude. He accused more than two hundred thousand civilians for being "Red" and killed them all in areas of Jeju, Yosu and Soonchon.
His government was one of the most corrupted governments and it ruled the country through the police dictatorship.
On April 19th, 1960, more than sixty thousand students revolted and chased Rhee out of Korea. He escaped on board of an American CIA plane.
We call this student revolt as Revolution-4.19 (Sa-il-goo-hyung-myung)
The next brutal government was that of General Park Chung-hee who ruled from 1962 to 1979 through military-CIA dictatorship. To silence voices of criticism and objection, he used innocent citizens to produce false North Korean spies.
Millions of families which had nothing to do with North Korea were the target of police harassment for the simple reason of knowing somebody who had liberal ideology.
There were many who killed themselves by burning, because, in the absence of freedom of speech, it was perhaps only way of accusing injustice and violation of human rights.
From October 16 to 20 of 1979, more than fifty thousand students in Busan and Masan (BU-MA) areas revolted against electoral fraud committed by General Park and this is known as Resistance-BU-MA (Bu-ma-hang- jaing).
General Park was assassinated by his CIA director, Kim Jae-kyu, on October 26, 1979.
The conservative government following Park Chung-hee's was that of General Chun Doo-hwan who ruled from 1979 to 1987. He was as brutal, if not more, as General Park.
His most subhuman crime was the massacre of Kwang-ju citizens on the 18th of May, 1980.
About nine hundred were killed by the Korea army who used even helicopters to shoot down the citizens of all ages; more than one thousand were injured.
It started by a peaceful demonstration against injustice and violation of human rights, but General Chun wanted to destroy the very roots of complaints against him and falsely accused the citizens as soldiers from North Korea.
This incident is called Kwang-ju Fight for Democratization-5.18 (Oh-il-pal- kwang-ju-min-ju-hwa-un-dong).
General Chun was tried and condemned to death but pardoned by President Kim Dae-jung. He was also accused for embezzling several hundred millions of US dollars.
The dictatorship of the conservative government had continued until June, 1987 when far more than one million citizens took the street to stop the system of indirect election of president and amend the constitution allowing direct presidential election.
This huge demonstration is called the June Resistence (Yu-wol-hang-jaing).
Chun was succeeded by another general, Rho Tae-woo (1987-1993) who continued military rule. He was condemned and imprisoned for the embezzlement of millions of dollars and corruption.
After the five-year rule of the government of Kim Yong-sam (1993-1998) during which the military domination became less visible, the two liberal progressive governments took power.
Ten years of liberal progressive government of Kim Dae-jung (1998-2003) and Rho Moo-hyun (2003-2008) was a period of peace and North-South multi-dimensional cooperation.
And democracy was restored.
But, the restoration of democracy and inter-Korea peace was broken when President Lee Myong-bak took power in 2008.
He ended all inter-Korea contacts in 2010 by virtue of a decree of May 24 of 2010, called Policy Measure-5.24 (Oh-ie-sa-jo-chi).
This Policy Measure prohibited North Korean ships from using South Korean harbours, cut off all North-South trade, prohibited South Korean citizens from traveling to North; it made illegal South Korean investments in North Korea. In addition, it stopped all aids to North Korea.
In short, the Policy Measure-5.24 meant a complete cessation of North-South dialogues and cooperation.
The end result of this Policy Measure was the intensification of the North-South tension, which inevitably facilitated the conservative government's control of media and political movement of the liberal progressive group.
Lee Myung-bak ruled through the dictatorship of CIA, the police and even military intelligence service.
Lee Myong-bak is now in prison and accused of the manipulation of social media for his presidential election, embezzlement of millions of dollars, abuse of power and transaction of influences and several other crimes of corruption.
His successor, Mme Park Geun-hye (2013-2017), daughter of General, Park Chung-hee, took power in 2013. She repeated what Lee Myung-bak had done, may be even more.
She made a black list of ten thousand artists, filmmakers, actors, journalists and civil movement leaders to silence their voice of criticism.
She has embezzled a huge amount of money in complicity with her friend Choi Sun-sil; she mobilized the whole government agencies of power for her personal greed and ambitions.
She is now in prison to serve 24 years of imprisonment.
Thus, South Korea has had six conservative presidents. Of these six, one was chased away by students, one was assassinated by his CIA director, four are or were imprisoned for abuse of power, embezzlement of public funds and violation of human rights.
The Korean people have, under these politicians, endured the 55-year dictatorship; they suffered from fear and anguish produced by the brutality of authorities; they were fed up with the never – ending corruption of high-placed people.
But, they did fight back; for seven months from 2016 to 2017, 17 million people of all ages, all regions and all sectors of the society took the sub-zero cold streets of Kwanghwah-Moon of Seoul and elsewhere in the country.
And they produced the miracle of the Candle-Light Revolution (Chop-pool- hyung-myung).
The Candle-Light Revolution impeached Park Guen-hye and elected, as President, one of the most honest, the most competent and the most loving men in the modern history of Korea.
His name is Moon Jae-in who will lead the destiny of Koreans toward the society of security, justice, equality and prosperity. More than 80% of South Koreans have faith in him.
With Moon Jae-in, the North-South tension is attenuated and the democracy is restored again after 55-year dictatorship of all sorts committed by the conservative government
The second type of cost imposed on South Korea was the increase in Korea risk preventing a normal inflow of foreign direct investments (FDI). South Korea shows one of the lowest FDI ratios among the OECD countries. In 2017, the ratio of inflow FDI stock to GDP was 12.0 % as against 52.0% for OECD countries.
Finally, another heavy cost was the total destruction – by Lee Mung-bak and Park Gun-hye – of the groundwork of Korean reunification carefully established by the two liberal progressive governments of Kim Dae-jung and Rho Moo-hyun
In short, the nuclear crisis on the Korean peninsula has imposed heavy cost on South Korea and its people. This cost includes, as seen above, the retreat of democracy, the destruction of the groundwork of the country's reunification and negative impact on its economy.
To conclude, if the Singapore Summit is successful so that denuclearisation takes place, it will be a great blessing for South Koreans.
They will be able to further develop true democracy, advance toward the reunification of the Korean peninsula, a new round of the rapid economic development.
Professor Joseph H. Chung is currently associated professor of economics and co-director of the Observatory of East Asia (OAE) of the Study Center for Integration and Globalization (CEIM), Quebec University-Montreal Campus (UQAM). He is a Research Associate frequent of the Centre for Research on Globalization (CRG).


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James Vincent is a "world class" musician. That he is not a household name is entirely by his choice, yet almost all who have seen him perform or heard his recordings have become his fans. He has written a unique, brutally honest account of his life his childhood and discovery of the guitar; his going on the road at seventeen to play in seedy dives and military service clubs; later, in famous upscale clubs across the country; then making records and playing huge concert venues. James gives us an inside look at the recording industry the studios, the performers, producers and promoters. He gives us behind the scenes insights into many famous personalities names like Santana, Garcia, Harrison and Cetera, and acknowledges some unsung heroes in the music world. His cast of characters includes the very rich and the down and out, the saint and the prostitute, the famous, the infamous and the very bizarre. This is a story about learning the hard way; about dysfunctional families, choices and consequences, lust, infidelity, despair, triumph, tragedy, friendship and betrayal. Most of all, it is a life's journey to discover the meaning of unconditional love and spiritual fulfillment. It is indeed, an odyssey. ?R.J.M.
Raised in the blues-rich South Side of Chicago, guitarist James Vincent studied the methods of B.B. King and Johnny Smith, as well as the great Chet Atkins. In the mid-sixties, Vincent played in the legendary ?Exceptions,? considered by many to be Chicago?s first super group. Vincent recorded with several notable Chicago artists, including Minnie Ripperton. In 1969 Vincent joined ?H.P. Lovecraft,? managed by rock impresario Bill Graham. He later toured with Jerry Garcia in promotion of Jerry?s ?Hooteroll? album. Vincent recorded three solo albums with Columbia/Caribou Records, including ?Space Traveler,? featuring members of ?Earth, Wind & Fire,? followed by two contemporary Christian albums, ?Enter In? and ?Waiting for the Rain.? Some of his past musical associations include Santana, Rufus, Azteca, Sheila E., Neal Schon, Etta James, Tom Scott, and Robert Lamm of the band ?Chicago.? Vincent lives in southwestern Idaho?s Treasure Valley.


text:
G1 Therapeutics: Depressed Price Before Catalyst, No Apparent Reason – Seeking Alpha
Posted: November 27, 2020 at 1:47 pm
We were discussing G1 Therapeutics (GTHX) in our TPT member chat yesterday. It has been a depressed stock for over a year now, and even today, despite having a PDUFA date in less than 3 months, the stock shows little sign of improvement. Lead drug candidate trilaciclib is a myelopreservation agent supporting chemo regimens that have shown enough data in phase 2 trials that the FDA has allowed GTHX to proceed to an NDA directly from there without requiring a phase 3 trial. Rintodestrant, their second asset, is in early stages of developing but targeting a larger opportunity in breast cancer and is going to announce a major update on December 9; and yet, the stock shows no sign of improvement.
Their current pipeline looks like this:
I covered trilaciclib a year ago. There is not a lot to be added to that except that their NDA was accepted by the FDA on August 17 with a PDUFA date for February 15, 2021. The NDA was accepted under an accelerated review program, which is why PDUFA is occurring in 6 months instead of the regular 10. The Priority Review is based on positive data from three randomized clinical trials showing robust myelopreservation benefits for the drug.
There are currently no available therapies to protect patients from chemotherapy-induced toxicities before they occur, said Raj Malik, M.D., Chief Medical Officer and Senior Vice President, R&D. If approved, trilaciclib would be the first proactively administered myelopreservation therapy that is intended to make chemotherapy safer and reduce the need for rescue interventions, such as growth factor administrations and blood transfusions.
Trilaciclib also has a Breakthrough Therapy Designation - meaning preliminary clinical evidence for trilaciclib shows a clear advantage over available therapy. In the NDA acceptance letter, the FDA also stated that it is currently not planning to hold an advisory committee meeting for the drug.
While undergoing chemotherapy, many patients experience significant myelosuppression, become fatigued and susceptible to infection, and often require transfusions and growth factor administrations, said Jared Weiss, M.D., Lineberger Comprehensive Cancer Center, University of North Carolina Chapel Hill, NC. Preventing bone marrow damage proactively is an opportunity to improve the quality of life of patients receiving chemotherapy for small cell lung cancer and reduce costly rescue interventions.
Myelosuppression, caused by damage to bone marrow stem cells, occurs due to chemotherapy and can cause symptoms like anemia, neutropenia or thrombocytopenia. In clinical trials, trilaciclib has demonstrated strong reduction of chemotherapy-induced myelosuppression, and patients receiving trilaciclib experienced fewer dose delays/reductions, infections, hospitalizations, and need for rescue therapies compared to patients receiving chemotherapy alone.
Another important development is trilaciclibs expanded access program, which means the company is making the drug available to patients while it undergoes the approval process. The EAP usually means the drug is so beneficial that it is unethical to make patients wait even a few months to get it. This is an important development because it shows the value of trilaciclib.
In June, G1 Therapeutics entered into a 3-year US/Puerto Rico co-promotion agreement with Boehringer Engelheim, which has a lot of experience in oncology asset commercialization. GTHX will book revenue and retain full commercialization rights, and will pay Boehringer a promotional fee based on net sales. G1 will pay a promotion fee of a mid-twenties percentage of net sales in the first year of commercialization, which decreases to a low double-digit/high single-digit percentage in the second and third years of commercialization, respectively.
As for the total addressable market or TAM, over 25,000 people in the U.S. and Puerto Rico are diagnosed with SCLC every year. Approximately 90% of SCLC patients receive first-line chemotherapy treatment, and approximately 60% of those patients receive subsequent second-line chemotherapy treatment. That means, there are 22,500 patients in the 1st line setting who will benefit from trilaciclib, and another 13,500 patients in the 2nd line setting. That is a total of 36,000 patients. From research available last year, cost of chemotherapy treatment for SCLC patients was around $60,000. If we assume a 10% cost for trilaciclib, then we have $6000 per patient. So, every year, they are looking at a TAM of $216mn in this one indication in the US. With Boehringers involvement, we can safely assume a 10% penetration within the first two years of approval, especially given the breakthrough designation. So, that is $22mn from the US; similar figure for Europe, and another such figure from the RoW will give us $60mn in about 3 years, with increasing penetration of the market.
This is a conservative estimate. As I wrote in my earlier coverage:
According to a 2027 estimate by Decision Resources Group, trilaciclib has the potential to benefit a significant number of patients beyond SCLC. There were approximately 1 million chemo treated patients including adjuvant/1L CRC, 1L NSCLC, and adjuvant/1L BC in the U.S., Europe, and Japan in 2018. Chemotherapy treated patients include:
68,000 - ES-SCLC (1st Line - 3rd Line)
68,000 - 1st Line BC
126,000 - 1st Line NSCLC
356,000 - Adjuvant & 1st Line CRC
354,000 - Adjuvant BC
This vast cohort of patients can benefit from trilaciclib in combination with chemotherapy. The company estimates the target market to be at $3bn.
Trilaciclib is a first-in-class drug and doesn't have real competition. It could replace current rescue growth factor support treatments, "including Neulasta (pegfigrastim), Neupogen (filgrastim), Procrit (epoeitin alpha), and Aranesp (darbepoetin alfa)."
Trilaciclib is also being evaluated in other cancers. From their press release:
In a randomized trial of women with metastatic triple-negative breast cancer, preliminary data showed that trilaciclib improved overall survival when administered in combination with chemotherapy compared with chemotherapy alone. The company plans to present final overall survival data from this trial in the fourth quarter of 2020.
On November 18, the company announced that final overall survival data from the mTNBC trial was consistent with the above preliminary findings announced last year, and showed that trilaciclib significantly improved median OS for patients treated with trilaciclib in combination with a chemotherapy regimen of gemcitabine/carboplatin.
They will initiate a pivotal trial in mTNBC in 2021 with OS as the primary endpoint.
Trilaciclib is being evaluated in neoadjuvant breast cancer as part of the I-SPY 2 TRIAL, and the company expects to initiate a Phase 3 trial in patients treated with chemotherapy for colorectal cancer in the fourth quarter of 2020.
In the same press release quoted above, GTHX also announced that it will provide an update on Rintodestrant at the 2020 San Antonio Breast Cancer Symposium (SABCS) to be held virtually on December 9, 2020. Specifically, they said The company will also present updated monotherapy findings from the Phase 1 portion of its ongoing clinical trial of rintodestrant, a potential best-in-class oral selective estrogen receptor degrader (SERD) in development for treatment of ER+, HER2- breast cancer.
It seems they will provide pk/pd and mtd (maximum tolerated dose) data, with probable comments on early signs of efficacy. Primary outcomes are dose limiting toxicity and phase 2 dose determination. secondary outcomes are about efficacy, specifically tumor response with RECIST, and pk/pd. Before competitor fulvestrant went generic last year, it had $541mn annual sales. This indicates the potential for Rintodestrant.
I am providing below the entire abstract on Rintodestrant - there will be three of these but this is the critical one.
Background: Rintodestrant (G1T48) is a potent oral selective estrogen receptor degrader (SERD) that competitively binds to the estrogen receptor (ER) and blocks ER signaling in tumors resistant to other endocrine therapies. Preliminary results from Part 1 dose escalation showed robust target engagement on 18F-fluoroestradiol positron emission tomography (FES-PET), a favorable safety profile, and encouraging antitumor activity in patients with heavily pretreated ER+/HER2- advanced breast cancer (ABC), including those with ESR1 mutations (Dees et al., ESMO 2019 [abstract #3587]). Here, we present updated results from dose escalation and expansion (Parts 1 and 2). Methods: This Phase 1, first-in-human, open-label study evaluated rintodestrant monotherapy in women with ER+/HER2- ABC after progression on endocrine therapy. Part 1 was a 3+3 dose escalation (200- 1000 mg once daily [QD]); Part 2 expanded 600 and 1000 mg QD; and Part 3 was added to assess rintodestrant with palbociclib in patients in earlier lines in the advanced setting. Primary objectives included dose-limiting toxicities (DLTs), maximum tolerated dose (MTD), safety, and recommended Phase 2 dose. Secondary objectives included pharmacokinetics and antitumor activity (RECIST v1.1). Exploratory objectives included pharmacodynamic inhibition of ER target engagement (FES-PET), mutation profiling (cell-free DNA [cfDNA]), and change in ER expression from baseline to on-treatment tumor biopsies. Results: As of May 13, 2020, 67 patients (Part 1: n = 26; Part 2: n = 41) were treated, with a median age of 61 years (range 34-83) and ECOG PS of 0 (49%) or 1 (51%). Median number of prior lines in the advanced setting was 2 (range 0-9), including prior fulvestrant (64%), CDK4/6 inhibitor (69%), mTOR inhibitor (22%), and/or chemotherapy (46%). Median number of prior lines of endocrine therapy in the advanced setting was 2 (range 0-5), with 61% of patients having received 2 lines. Treatment-related adverse events (TRAEs) were reported in 70% of patients. The most common TRAEs in 10% of patients included hot flush (24%), fatigue (21%), nausea (19%), diarrhea (18%), and vomiting (10%), mostly grade 1 or 2. No DLTs were reported and MTD was not reached. Dose reduction due to TRAEs occurred in 1 patient (1%), with elevated transaminases (grade 3 ALT and grade 2 AST) at 600 mg. Serious TRAEs occurred in 2 patients at 1000 mg (grade 5 cerebral hemorrhage in the setting of low molecular weight heparin and grade 2 upper abdominal pain). Two patients (3%) discontinued treatment due to TRAEs. Overall, the frequency of patients with TRAEs at 800 mg was comparable with that at 600 mg (57% vs 63%) and less than that at 1000 mg (81%). Of 67 patients, 16 were on study treatment for 24 weeks and 3 (n = 1 at 600 mg; n = 2 at 1000 mg, including 1 with ESR1 mutation) had a confirmed partial response (clinical benefit rate [CBR]: 28%). FES-PET standard uptake values decreased at week 4 with a mean reduction of 87% (8%) at doses 600 mg. Of 59 patients tested for baseline cfDNA, 41% harbored 1 ESR1 mutation, with a similar CBR in both groups (33% in ESR1 mutant and 29% in ESR1 wild-type). Seven of 9 patients had a decrease in ER immunohistochemistry H-score at both 600 and 1000 mg (median [range]: -27.8% [-33.8%, - 3.4%]), irrespective of ESR1 mutation status. Based on safety, efficacy, and ER degradation, 800 mg was selected as the optimal dose for further study. Conclusions: Rintodestrant continues to demonstrate an excellent safety/tolerability profile across all doses, with promising antitumor activity in patients with heavily pretreated ER+/HER2- ABC, including those with tumors harboring ESR1 mutations. Part 3 of this study, evaluating rintodestrant 800 mg QD with palbociclib in a more endocrine-sensitive population, is ongoing (NCT03455270).
There is not a lot to comment here. 800 mg seems to be the optimal dose, and that one patient with grade 5 cerebral hemorrhaging may be an outlier, especially with heparin in the mix, but that is something to keep an eye out for. Effect on an endocrine-sensitive population is preliminary but encouraging, and although a partial response, at this late stage in the game, that is not a bad deal. A larger trial developing the ESR1 scenario more fully is going to be interesting to watch.
According to latest reports, the company has $200-205mn in cash and cash equivalents as of the latest quarter. Burn was around $90mn last year, so with the Boehringer deal, that is not going to increase substantially, putting them in a comfortable position with a 2-year cash runway. The company recently changed CEOs, which seems to be in anticipation of approval, and nothing else.
For whatever reasons I cannot fathom, the stock remains depressed. They have a major catalyst 3 months down the line, and if past performance in trials is anything to go by, theres considerable chance of approval. Post approval scenario, both in terms of revenue stream and label expansions/other indications, looks good. I think this is a good candidate to accumulate at this time.
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The bull bumped its head against the resistance this week but recovered to face the resistance again by the end of the week. Next week will be telling. Either the market goes up or corrects from here. It is still too soon to say until we see February.
I didn't do much this week but to witness $CGC sped ahead without me. So much for the double-top scenario. I will continue to look for an opportunity to jump back in.
I'm beginning to get a feeling that $AEMD and $IBIO are approaching a pivotal point where everything is going to change for the better. My 2 cents is that we may hear breaking news of vital importance that may warrant a violent jump in price movement. If someone wants to buy Aethlon for its hemopurifier medical device, it will need to consider iBio for its ability to supply the hemopurifier's bio-materials at an economical cost. Logically speaking, you really can't use the hemopurifier without the bio-materials supplied by iBio. To do otherwise will incur a significant increase in the production cost of the bio-materials. Mammalian cells system will be cost prohibited if the plant-based tech is not utilized.
Basically, it seems to me that Dr. Rodell might be hired to handle the strategic transaction related to the recent Aethlon's hemopurifier Breakthrough Device Designation awarded by the FDA for metastatic cancer treatment.
Another nugget of information is that iBio is hiring more people. Take a look at the link below that takes you to the positions iBio is looking to fill.
One of the position is Accounts Payable/Receivable Clerk. This new position means they have enough new businesses to justify hiring a new person to handle billing such as invoicing to keep up with the pace.
In summary, despite uncertainty, there is a lot of signs on the wall that point to positive developments; so, I'm excited about these two companies.
$LRAD is slowly bouncing off the weekly 79 & 89 MA supports. As seen on the weekly chart above, it looks like it is ready to bounce higher. I'm very bullish on LRAD's technology, so I don't have a problem waiting on this one.
$SOLO – I am a believer in the single-seater EV; therefore, I expect the Solo to sell very well as soon as new batches of the Solo arrived from China. While we are waiting for the second quarter and onward to see a ramp up on the production run, I will be looking to accumulate more $SOLO with profits I expect to make from other positions.
Due to downdraft on $IBIO, $AEMD, and $SOLOW, my port gave back gain for the week.


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Tag Archives: chris richardson
Lil Wayne Attends 2013 BMI R&B/Hip-Hop Awards, Reunites With Curren$y, Juvenile & Mannie Fresh
August 23, 2013 in Cash Money Records, Latest News, Pictures, Young Money Ent
Cash Money bosses Bryan "Birdman" Williams and Ronald "Slim" Williams were saluted as BMI Icons last night at the 2013 R&B/Hip-Hop Awards ceremony, which took place at the Manhattan Center in New York City.
Guests that attended the show to support Cash Money Records included: Lil Wayne, Nicki Minaj, Detail, Caskey, Chris Richardson, Kevin Rudolf, Mack Maine, T@, Ray J, Ceelow, Jeff Panzer, Santi Cargo Rubirosa, Troy Bless, Trina, Future, DJ Khaled, Ace Hood, Mystikal, Turk, Curren$y, Mannie Fresh, Juvenile, and more.
During the show, Baby got on stage to give a speech and announce that YMCMB has sold over 500 million records, which is an amazing achievement! He also mentioned that Weezy is the realest person he has ever met: "This the realest nigga I ever met in my motherfuckin' life, his name is Dwayne motherfuckin' Carter"
You can check out some photos from the 2013 BMI R&B/Hip-Hop Awards show after the jump below, as well as footage of Lil Wayne, Juvenile, Turk, Mannie Fresh, Trina and Curren$y performing their old songs – "Bling Bling", "Back That Azz Up", "I Need A Hot Girl", "Moment 4 Life", and "Slow Motion".
Full Recap Of Cash Money's Pre-Grammy Party x Lil Wayne & Dhea Leave Staples Center [Videos]
March 7, 2012 in Cash Money Records, Latest News, Other, Young Money Ent
Above, you can watch Derick G's full recap of Cash Money Records' 3rd Annual Pre-Grammy Party on February 11th in Los Angeles, California at the Paramount Studios. In the video, you can see most of the Young Money Cash Money family arriving to the party, chilling and taking interviews on the carpet, having a good time inside the party, performing, and Lil Wayne's speech at the end were him and Drake receive their plaques, announces Christina Milian as the new artist signed to Young Mula, and disses The Throne! YMCMB a flashy lifestyle.
After the jump, you can watch some footage of Weezy, Dhea, Mack Maine and E.I. leaving the Staples Center after watching the Los Angeles Lakers vs. Miami Heat game on March 4th.
Video: Spliff Speaks To KTV About YMCMB x Pics: Lil Wayne Performs In Johannesburg
December 20, 2011 in Interviews, Other, Pictures, Young Money Ent
Above, you can watch KarmaloopTV's interview with Stephen 'Spliff' Hacker, which I found very interesting. Stephen manages some of the hottest producers in the music industry today, including: STREETRUNNER and Drew Money. In the interview, Spliff speaks on working with YMCMB, how Lil Wayne got hold of the "I Got Some Money On Me" beat that Spliff says he recorded in a day for Tha Carter IV album, and more. He also says Wayne has recorded 6 new songs in the studio over his producers beats, but does not know which project they are for.
After the jump, you can view some photos of Tunechi performing in Johannesburg, South Africa at the Coca-Cola Dome just over a week ago with Young Money's Drake, Shanell and Mack Maine.
YMCMB's 2011 Thanksgiving Day Turkey Giveaway (Part 2) [Video & Pics]
November 23, 2011 in Cash Money Records, Latest News, Pictures, Young Money Ent
Above, you can watch some official footage from YMCMB's 17th annual Thanksgiving Day turkey giveaway, courtesy of Derick G. Lil Wayne, Birdman, Slim, Mack Maine, Lil Chuckee, Detail, Chris Richardson and Dhea can all be seen in the video handing out turkeys to the people in New Orleans!
Hit the jump to view some photos DG took on the day, and click here to check out some other photos and footage that we posted last week.
Lil Wayne & YMCMB's 17th Annual Thanks Giving Day Turkey Giveaway [Video & Pics]
Yesterday, Lil Wayne and the YMCMB crew (Birdman, Slim, Mack Maine, Lil Chuckee, Chris Richardson and Detail) went back home to New Orleans to hand out turkey's for their "17th Annual Thanks Giving Day Turkey Giveaway". You can watch some short footage in the video above, were you can see Weezy's girlfriend Dhea and Derick G filming, which means we will probably get some official footage from the event soon. Below, you can check out some photos, courtesy of Capo.


The Raiders completed their second practice session Thursday without wide receiver Chaz Schilens, who left the field early on the session accompanied by a member of the athletic training staff and did not return to the field. Schilens, who missed the first eight games of the season with a broken metatarsal on his left foot and had two surgeries since, was not limping and its not known if his foot was the problem. About 30 minutes after practice, Schilens emerged from the hotel and walked back to the field house and still was not walking without a limp. The Raiders had no comment on Schilens' early exit and the interview sessions had concluded for the day.


Download Mercy - Brett Young (cover) by Genavieve as video and audio. This content is free of copyright, lagubagus.win is a search engine based on internet result.
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redpajama_set_name: RedPajamaGithub


I completed this painting during the summer. It is a particular favorite of mine, as it symbolizes a strong step forward for me in understanding light and shadow and how to paint it. I am going through an early "spring cleaning of my tiny studio" or else I would not post it on Ebay.


One of the joys of blogging at Art & Theology is being introduced to new artists by my readers. I was pleased to receive in the mail recently, as a gift from one such reader, a color booklet and a 2018 documentary on the art of Dom Gregory de Wit (1892–1978), a Dutch artist and Benedictine monk who between 1938 and 1955 lived in the United States painting murals for Catholic churches and monasteries. This was the first time I've encountered the artist, and I enjoyed getting to know him better through these materials.
All photos in this post are provided courtesy of Edward Begnaud or Stella Maris Films.
Gregory was born Jan Aloysius de Wit on June 9, 1892, in Hilversum, Netherlands. He entered the monastic life in 1913 at age twenty-one, joining Mont César Abbey in Leuven, Belgium, and there taking the name Gregory. (His interest in liturgy and ecumenism is what drew him to that particular abbey.) de Wit was passionate about art making since a young age, and his order encouraged him to further develop his talent as a painter. He therefore studied at the Brussels Academy of Art, the Munich Academy, and throughout Italy. In 1923 he exhibited at The Hague and ended up selling forty-five paintings in one month! He then went on to fulfill three sacred art commissions—one in Bavaria, two in Belgium—while continuing to live as a monk.
This mural, painted in 1930 and photographed here in black-and-white, shows Jesus serving wine at a monastic banquet. It's one of nine murals Gregory de Wit painted in the refectory of St. Michael's Abbey in Metten, Bavaria, Germany.
In 1938, Abbot Ignatius Esser of Saint Meinrad Archabbey in southern Indiana met de Wit in Europe and invited him to design and execute paintings for the abbey's church and chapter room—which he gladly accepted.
Here he started to develop his own style, which would come to be marked by brilliant (sometimes garish) colors, bold outlines, distortion or disfiguration (e.g., disproportionate hands), and "overlapping" perspective.
In Christus, Jesus is borne upward by a red-winged chariot. In his right hand he holds a victory wreath, and in his left, an open book that declares, EGO SUM VITA ("I am the Life"). The three small Greek letters in the rays of his halo, a traditional device in Orthodox iconography, mean "I am the Living One," a New Testament echo of God's "I am who I am" in Exodus 3:14.
This figure of the risen Christ, painted by Gregory de Wit in the 1940s, is found high on the wall of the church of Saint Meinrad Archabbey, St. Meinrad, Indiana.
Shortly after de Wit arrived in the US, World War II broke out, and even after he completed his work at Saint Meinrad, he couldn't return to Belgium. Luckily, another stateside commission came his way, from the newly built Sacred Heart Catholic Church in Baton Rouge, Louisiana. The parish priest, Father Dominic Blasco, hired him to paint a series of murals, which resulted in de Wit's most polarizing work: his Christ Pantocrator in the apse behind the altar. Many of the parishioners hated it (and I have to say, I'm not partial to it). A humorous anecdote in the documentary recalls Maria von Trapp, who had once visited the church, expressing her horror at the image to de Wit, not knowing he was its artist!
Not only did de Wit's art garner dislike, but so did his temperamental personality and sometimes irreverent behavior. For example, while at Sacred Heart, he smoked while he painted, dropping cigarette butts onto the floor during services. Although he did have his supporters, he was eventually fired from Sacred Heart. The last painting he did for the church was of the Samaritan woman at the well—descried as "pornographic" by the sisters of the school because of the suggestive way her dress clings to her forwardly posed thigh.
The painting at Sacred Heart that I'm most intrigued by is the Pietà in the narthex, which shows Mary holding her dead son. Genesis 3 is invoked by the thorns that not only crown Christ's brow but that rise up all around him, symbolic of the curse. What's more, a half-bitten apple rolls from his limp hand; he, like his forefather, Adam, has tasted death. And this he did willingly out of love, signified by the fiery, thorn-enwrapped heart of his that he holds in his right hand, whose glow illuminates the darkness.
Dom Gregory de Wit, OSB, Pietà, 1940–42. Narthex, Sacred Heart Catholic Church, Baton Rouge, Louisiana.
Because de Wit painted this image during the war, it is contextualized with a soldier on one side and the soldier's wife and three children on the other, praying for his safe return. Why do they belong in this scene? Some wartime artists drew parallels between Christ and the soldiers' sacrificial laying down of their lives (cf. John 15:13). I'm uneasy with this comparison for several reasons, not least of which is my Christian pacifism. But de Wit's painting seems, rather, to use the soldier and his family as a representation of war and to suggest that Jesus, the Suffering Servant, is with us in our present suffering. He entered our world, after all, and died to redeem us from its evils—sin and death and all their extensions. The presence of Mary, Our Lady of Sorrows, must have been a comfort to the mothers at Sacred Heart whose sons were overseas fighting.


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