Shimano compatibility charts come in handy for assembling your bicycle, planning purchases, or troubleshooting. We have included their compatibility charts from 2013 here as well as notes to these charts. The biggest change of the 2013 model year was the move to 11-speed, starting with the Dura Ace 9000 series. The 2013 charts were sourced from Japanese documentation, but language ability isn't critical to understanding them. Just follow the lines. Some translation provided. Comments welcome if anyone gets stuck.
Shimano's big announcement for the 2013 model year was the 9000-series, 11-speed Dura Ace groupset. Dura Ace Di2 9070 (2013 model) series is also announced. Compatibility of new Di2: they indicate no compatibility with 7970 or 6770 Di2 versions. 9000 series brake/brifter compatibility: Yes this component is compatible. ST-9000 shift lever, for example, can be used with BR-6700 caliper brake. 9000 series drivetrain compatibility: none. (chain, rear derailer, shifters, front derailer, crankset, cogset all show no compatibility with 10-speed models). Though compatibility charts show no connection between the new FH-9000 rear freehub and older 10-speed components (cogsets etc.), there are indications from the Shimano news release: 11-speed hubs will be reverse compatible, via a 1.85-mm spacer, so your 10-speed cassette can be used with them. Since the 11-speed cassette is wider though, it will not fit on 10-speed hubs.


We took a few days off this week and made a visit to family and friends near my hometown of Ringgold, GA. On Monday night we were able to reconnect with some college friends at Dave and Katie Delmotte's house. I first met Dave in a Greek class somewhere about 1993 or 1994. He moved to Chattanooga from Michigan. In order to communicate with one another Dave and I used a translator. Dave drove a jacked up Toyota truck with huge snow tires on it - in Chattanooga! Where I grew up, folks carried dead animals in the back of their truck. Dave was the only guy I ever met who carried hockey equipment in the back of his. Even when we drove up to his house on Monday afternoon I knew we were in the right place because Dave is the only person in the Bible Belt with hockey nets in his driveway.
Dave is now pastoring a church in rural Tennessee. I am not sure any of the people in his congregation have understood a single word he has spoken in the last five years, but God is using Dave despite the fact that he still sounds Canadian. It is Acts 2 all over again. One thing I have always appreciated about Dave is that he is tenaciously disciplined. He is a real student of the Word of God and carries through with implementing the Bible into his walk.
Before we left his home, Dave and Katie's son Jake, who is about 7, quoted some parts of the Book of James for us. He didn't quote some verses out of James, he was quoting James! Katie has worked with their children, reading James to them repetitiously, to the point that now their oldest child has it memorized. On the way back to my parent's house Shannon and I talked about how we, as a society, don't challenge our children enough, not just biblically, but academically as well. God created children with DVR. They naturally remember everything they see and hear. As parents we should seek to fill their minds with God's Word, pure thoughts, and great memories.
So, if you are ever playing ice hockey in Tennessee and someone body checks you and quotes a Bible verse, it was probably one of Dave's kids.


1. They develop competence in a variety of motor skills and movement patterns.
Learners develop the physical skills needed to enjoy participation in physical activities. Mastering movement fundamentals establishes a foundation to facilitate continued motor skill acquisition and gives students the capacity for successful and advanced levels of performance to further the likelihood of participation on a daily basis.
2. They apply knowledge of concepts, principles, strategies, and tactics related to movement and performance.
Learners use cognitive information to understand and enhance motor skill acquisition and performance. This involves the ability to use the mind to control or direct one's performance. This includes the application of concepts from disciplines such as motor learning and development, sport psychology and sociobiology, and biomechanics and exercise physiology.
3. They demonstrate the knowledge and skills to maintain a health-enhancing level of physical activity and fitness.
Learners establish patterns of regular participation in meaningful physical activity. This goal connects what is done in the physical education class with the lives of students outside the classroom. Although participation within the physical education class is important, what the student does outside the physical education class is crucial to developing an active, healthy lifestyle that has the potential to help prevent a variety of problems among future generations of adults. Students make use of the skills and knowledge learned in physical education class as they engage in regular physical activity outside the physical education class. They demonstrate effective self-management skills that enable them to participate in physical activity on a regular basis.
4. They exhibit responsible personal and social behaviors that respect self and others.
Learners self-initiate behaviors that promote personal and group success in activity settings. These include safe practices, adherence to rules and procedures, etiquette, cooperation and teamwork, ethical behavior and positive social interaction. Key to this goal is developing respect for individual similarities and differences through positive interaction among participants in physical activity. Similarities and differences include characteristics of culture, ethnicity, motor performance, disabilities, physical characteristics (e.g., strength, size, and shape), gender, age, race and socioeconomic status.
5. They recognize the value of physical activity for health, enjoyment, challenge, self-expression, and/or social interaction.
Learners develop an awareness of the intrinsic values and benefits of participation in physical activity that provides personal meaning. Physical activity provides opportunities for self-expression and social interaction and can be enjoyable, challenging and fun. These benefits develop self-confidence and promote a positive self-image, thereby enticing people to continue participation in activity throughout the lifespan.
All students have access to regular physical education. Physical education is consistent with class size, and students have access to adequate equipment and facilities in order to work to their potential in a purposeful manner.
Physical education has a written, sequential curriculum for all grades which is based on national and state standards for physical education. Physical education instruction in motor skills is designed to enhance the physical, social/emotional and mental development of each child and helps children understand, improve and maintain their physical well-being. It provides many opportunities to improve social and cooperative skills and to develop a multicultural perspective.
Appropriate instruction involves the full inclusion of all students, well-designed lessons that support out-of-school learning and practice and an abundance of opportunities for class activities. Physical activity is never used or withheld as punishment and is always regularly assessed as a way to monitor and reinforce student learning.
Assessment is an ongoing, vital part of the program and student assessments are always aligned with state and national physical education standards. Physical education program elements are assessed in order to ensure they support a quality physical education program.


On October 21, 2016, a notably significant Internet security event occurred affecting millions of U.S. Internet users via an army of hacked Internet-connected devices.
Normally we don't think too much about the security of our seemingly helpful and harmless home routers, DVRs, surveillance cameras, cable set-top boxes and other systems we use every day, though there are plenty of indicators we should attend to making them more secure.
In this case, the Mirai botnet — an army of infected routers, IP cameras, DVRs, CCTV and other Internet-connected devices — conducted a distributed denial of service (DDoS) attack against the Dyn Managed DNS infrastructure.
Unable to handle Mirai's barrage of traffic, Dyn could not direct Internet users to its clients' Web platforms including Twitter, Netflix and Amazon. Dyn battled the effects of the attacks for over 11 hours.
The Department of Homeland Security (DHS) Industrial Control System – Cyber Emergency Response Team (ICS-CERT) logged these types of attacks as part of its incident response analysis and has issued numerous reports and advisories since 2009.
Further, there is real concern regarding Mirai and other botnet attacks such that ICS-CERT issued Alert (TA16-288A).
Hopefully your organization stays current with ICS-CERT's work and its advisories for the benefit of security and risk awareness.
We haven't seen the end of this type of attack – botnet software has been made publicly available and requires little skill for various threat actors to begin tinkering with it. The Mirai botnet DDoS attack on Dyn was highly sophisticated and orchestrated in a specific manner to cause the greatest possible outage, but the application of this type of attack against industrial organizations could not only disrupt industrial products and services but could potentially impact public safety.
Does your industrial organization use wireless routers, cloud services in the production network, SSH or Telnet for remote administrative access or routinely allow trusted employees and contractors to attach their laptops, tablet devices or USBs into systems under maintenance? Many do – these are common use cases within industrial environments. However, as more and more pervasively connected "things" take advantage of new Internet connections, processes and services, our growing dependence is not keeping pace with increasing security concerns.


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redpajama_set_name: RedPajamaCommonCrawl


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Robert G. Guddie
Robert G. Guddie 89, passed away Sunday November 6, 2016 in Seasons Hospice IPU, Waukesha. He was born July 19,1927, in Milwaukee, the son of Joseph and Alice (Nee: Acker) Guddie. He married Naomi (Nee: Wahl) on September 3, 1966, in Eau Claire WI. A graduate from St. Francis High School, Bob was a police officer for the Milwaukee Police Department for 38 years. Bob was a proud Army veteran and served his country in WW II. He had a passion for life and enjoyed spending time at his cabin in Crivitz WI. where he loved to hunt, fish and sometimes golf. He enjoyed drinking fine scotch and smoking cheap cigars. But his most prized possession were his grand kids, who he loved very much. He will be deeply missed by his wife of 50 years, Noni, and 2 sons, Robert (Linda) and George (Rebecca) Guddie. He will also be missed by his 6 grandchildren, Jenna, Jack, Benjamin and Eli, Tess and Grace and 1 brother Jack (Nancy) Guddie. Bob is also survived by other nieces, nephews, relatives and friends. He was preceded in death by his parents, 2 brothers and 1 sister. A funeral service will be held Wednesday November 9, 2016 at 7 pm, in the Emanuel United Church of Christ—Hales Corners (10627 W. Forest Home Ave. Milwaukee 53130). Pastor William Utke officiating. The family will receive guests in church on Wednesday November 9, 2016 from 5 pm until the time of service. Burial will be private for the family. DAD YOU BE WILL BE GREATLY MISSED


Having grown up in Istanbul, Turkey, both of us come from a region rich with historical layers and multi-sided political upheavals. As we were raised in this geography with its enigmatic qualities, we encountered the contradictions of everyday life heavily loaded with oppressive patriarchal culture and state violence. Therefore, we always struggle with/are interested in how to deal with those contradictions and be part of the political milieu, which constantly requires documentation, action, reflection—as students or scholars—in our writings or media works.
This might be one of the reasons why we feel in resonance with Rabih Mroué's works, including those he has been presenting in Vancouver since early January: his exhibition Nothing to Lose at grunt gallery, and his lecture-performance Pixelated Revolution during the PuSh Festival. The questions we came up with after long discussions with the artist are strongly intertwined with our own feelings and thoughts. Those questions turned out to be quite personal and emotional on some levels and yielded a conversation that opens ways to question/rethink/transform our thoughts and feelings in parallel to Rabih Mroué's works.
You call your work, Pixelated Revolution, a "non-academic lecture," and lectures are not normally thought of as an art genre. There seems to be a tendency to approach the work as an intellectual argument, like an essay, like a lecture. What role does this aspect of the work play in what you are trying to achieve?
I studied theatre, so I do theatre mainly. For me theatre contains many layers: acting, story, lighting and sounds in addition to "this is the space" (gesturing to the space around him). A very important matter is how you treat the space, what relation there is between the stage and the place where the audience is sitting. For me this relation should be always under question. The works that I categorize as "non-academic lectures" are basically like performances. But what distinguishes the non-academic lectures from performance, in my opinion, is that it does not question the space at all, and I take the relation between the stage and the audience for granted. So from the beginning, I accept this relation and the audience accepts it as well. You know it is lecture form: there is a table, a chair, and I sit and I lecture to the audience. The audience listens to me and at the end we have a Q&A discussion. There is nothing special to the relation, so this is why I name it as non-academic lecture. It is not theatre and it is not performance, because it doesn't contain the question of space. But also there are other aspects that make me call them non-academic lectures than the space issue like, for example, the lack of references and quotes, or mixing the personal with facts, the real with fiction, etc.
Your works seem to return to seemingly related issues, like memory, remembering and forgetting, especially within political realms of struggles, wars and revolutions. In your works, what is the central problem that you often return to that shapes the ways in which you deal with the materials you are working with?
What fascinates us in your works is that you start with a very simple observation or question. It can be the last testimony of a martyr, or can be about a Syrian revolutionary who is shooting his own death, as you discuss in Pixelated Revolution. You start with these very basic incidents and work through them, unfolding significant tensions and relations between experiences. We see that you are going back to these incidents, these micro-moments, within larger societal issues. Can you elaborate on why going back to these small incidents is significant to your work?
This is a difficult question because you know about the recent Gezi Parkı uprising in Istanbul. I was there, Eylül was here. Being here and not there was difficult for her, and there was a sense of guilt. In your work I, the Undersigned, you make an apology, stating that "I apologize that during the war I incurred no physical wounds, that I wasn't kidnapped, that no one attempted to assassinate me, and that I received no personal threat." Why an apology? This part of your work really affected us since we could relate it to a feeling of guilt we suffered from during Gezi Parkı demonstrations when we were watching protestors on internet live-streaming as they were recording the state violence targeting them and getting detained by police. Many times we felt guilty for not being injured, not being detained. But at the same time we feel uncomfortable with this sense of guilt because we feel that no one should be ready to position their body as a target to such violence for any cause. How do you approach that difficult issue of guilt?
What you are trying to evoke is a very important issue because when I put the statement that "I apologize for not being kidnapped, not being injured, not being a target for assassination or I, the undersigned,threatened by anybody," I was trying to play with it. Because I noticed that some citizens who stayed the whole period of the civil war in Lebanon were aggressive towards other citizens who did not stay in Lebanon or who left the country during the war and by consequence were not allowed to talk about "our war" since they did not experience it or since they fled the city etc. It is as if, if you stay in the country, live the war and suffer it with your body, then you gain a kind of passport that gives you the right to talk about it and to stop any "other" person who would like to talk about it. As if you gain a "truth" that allows you to be the presenter and representer of the period. Actually, I went too into this trap, but in fact it does not need much to discover that this is a naïve, childish attitude because there are a lot of valuable studies and excellent reflections that have been done by writers or artists or philosophers who did not live a war or the specific event that they are dealing with. Anyone has the right to talk on any subject she or he wants to…and one can make serious work by studying and working and also by researching and asking about this subject, by really trying to understand… Of course it would not be the same result as someone who lived the events, but this also does not mean that the latter would talk about it in a good way or even in an interesting way… If we did not live the danger, that doesn't mean that we don't have the right to talk about the issue.
Our last question is about your approach to the binary of fictive and real. There seems to be a common obsession to question the truth behind an image; many are concerned with fictiveness and constructedness of an image, and hesitate to believe in it. How do you deal with this binary of fictive and real?
It is something that I worked on for long time with my partner, Lina Saneh. We don't believe that there is an absolute truth. There are always different points of view and different angles to look into the same thing. No one can pretend to have all the versions that talk about a specific event. There could be some versions missed, some angles that haven't been seen, and we shouldn't blame ourselves that we couldn't cover all the angles, because it is an impossible task. In this sense, there is always a part that is missing and a part that is bit fictive and maybe relates to the subjective. So subjectivity and objectivity are two things that work together. They are not separated from each other; at least we don't separate them. We try to take cases and put inside them some fictive elements, but not in order to cheat the audience; on the contrary, it is in order to tell them and tell ourselves that in every narrative there is a part of fiction and part of real, and the issue is that we cannot distinguish the real from the fiction and the fiction from the real. If we are trying to do that, then we will be falling into the dichotomy trap, a binary discourse between fiction and reality, lie and truth, good and evil. For Lina and I, we try to accept any version, even if we notice that this version is completely fabricated; we accept it as the reality of the side that is telling this version and we study it as it is. We take it and study it as if it is true and start to deconstruct this version and to ask questions about it and try to understand what it shows and what it hides, but without accusing, without saying that they are lying, they are manipulating the truth. We just try to understand the political and social discourse behind this version. There are always some people who come to me and ask if "this was a fiction or real?" I always say that it doesn't matter. I am proposing this work to you, so just take it as it is and think about its meaning. I am not aiming to change the world; my work is only about raising some questions and some thoughts — some doubts to make us think together.


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@abdul-weenab Yes! It is also for men.


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The main update is the Soft-Ride suspension, which improves soil clearance by 8 millimeters (.31 inches). The Chevy Beat Activ is set to appear at dealerships in Mexico on July 11.


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iDEG: a new single-subject method for assessing gene differential expression from two transcriptomes of an individual

Qike Li

qike.li@gmail.com

qikeli.github.io

Outline

Background

Methodology–iDEG

Numerical studies

Real data analysis

Background

Precision Medicine

Single-subject analysis

Example RNA-Seq quantified mRNA expression data (Single-Subject)

Our goal

Main Challenges

Our solution (iDEG)

Precision Medicine

Single-subject analysis

Single-subject analysis studies  one patient at a time, with the purpose of revealing the  patient-specific disease mechanism for highly heterogeneous diseases.

Single-subject analysis

Example RNA-Seq quantified mRNA expression data (Single-Subject)

Table 1: Single-subject RNA-Seq data example

<colgroup>
<col  class="org-left" />
</colgroup>

<colgroup>
<col  class="org-right" />

<col  class="org-right" />
</colgroup>

Gene
Case expression
Baseline expression

A1BG
92
72

A1CF
1
0

A2BP1
0
2

A2LD1
127
71

A2ML1
773
12

A2M
11825
29385

A4GALT
871
891

A4GNT
1
5

AAA1
0
0

AAAS
414
460

…
…
…

 Table 1: Data source https://portal.gdc.cancer.gov/

Our goal

How differentially expressed is a gene?

A meaningful effect size of differential expression

What is the uncertainty of the measurement?

A probability of gene differential expression.

Main Challenges

Main challenges in single-subject analysis:

There are NO  within subject replicates.

Main Challenges

Main challenges in single-subject analysis:

There are NO  within subject replicates.

Different genes have different variances.

For each gene, we have only two numbers to work with.

Our solution (iDEG)

Bypass gene-level variance estimation: Transform RNA-Seq data such that, under null hypothesis, all genes have the same variance.

Borrow strength across genes: model all genes in a single model

Methodology–iDEG

Data transformation

Two-group mixture model

Data transformation

Data transformation

Data transformation

Under null hypothesis:

 \begin{eqnarray}
 \qquad Z_{g} &=& h(Y_{g2}) - h(Y_{g1}) \overset{\cdot}{\sim} \text{N}(0,c) \\
    && \text{  where } c \text{ is an unknown constant}
\end{eqnarray}

Two-group mixture model

Suppose \(G\) genes are measured in the RNA-Seq experiment, each of the genes is either null or differentially expressed with prior probabilities \(\pi_{0}\) or \(\pi_{1} = 1-\pi_{0}\). And the density function of \(z_{g}\) is either \(f_{0}(z)\) or \(f_{1}(z)\).

\begin{eqnarray*}
      \pi_{0} &=& Pr\{\mbox{gene $g$ is null}\} \\
    \pi_{1} &=& Pr\{\mbox{gene $g$ is DEG}\}
\end{eqnarray*}

The marginal mixture density is:

\begin{equation*}
  \label{eq:mixtureDens}
  f(z) = \pi_{0}f_{0}(z) + \pi_{1}f_{1}(z)
\end{equation*}

Two-group mixture model

The local false positive rate, \(fdr\), is the Bayes posterior probability that a gene \(g\) is a null gene given \(z_{g}\):

\begin{equation*}
  \label{eq:locfdr}
  fdr(z) \equiv Pr\{\text{null gene} | z\} = \pi_{0}f_{0}(z)/f(z)
\end{equation*}

Two-group mixture model

\(f_{0}\) corresponds to an empirical null distribution.

In large-scale simultaneous hypothesis testing, the theoretical null may be deficient due to various reasons:

correlation across genes

unobserved covariates (e.g. gender, age, smoking status, etc.)

or failed mathematical assumptions (e.g. asymptotic approximation).

Fortunately, in large-scale simultaneous testing, the parallel structure allows the estimation of an empirical null distribution, via empirical Bayes, from the own data of the study.

Numerical studies

Simulate a single-subject dataset

Procedure

Method evaluation

Sensitivity Analysis

Simulate a single-subject dataset

Simulate a pair of transcriptomes:

\begin{eqnarray*}
  Y_{g1} &\sim& \text{NB}(\mu_{g1}, \delta_{g})\\
  Y_{g2} &\sim& \text{NB}(\mu_{g2}, \delta_{g})\\
  \delta_{g} &=& 0.005 + 9/(\mu_{g1}+100) \\
P(\mu_{g1}) &=& \frac{1}{500} e^{-\frac{1}{500} \mu_{g1}} \quad \quad g = 1,\cdots,20\,000
 \end{eqnarray*}

Simulate a single-subject dataset

  Cont'd

\begin{eqnarray*}
\mu_{g2} &=& \begin{cases}
\mu_{g1}  & \text{if }g \in \overline{\mathcal{G}},\\
d^{s}\mu_{g1}   & \text{if }g \in \mathcal{G}.\end{cases}\\
&&\text{where $\mathcal{G}$ is a random subset of set $\{1,2, \cdots, 20000\}$}\\
\frac{|\mathcal{G}|}{|\mathcal{G}| + |\overline{\mathcal{G}}|} &=& 0.05 \label{eq:DEG-pct}\\
d  &=& \frac{\mu_{g1} + n \sqrt{\mu_{g1}}}{\mu_{g1}}\label{eq:DEG-fold-change}\\
s &=& \begin{cases} 1 &\text{with probability of }0.5,\\
-1 &\text{with probability of }0.5.\end{cases} \label{eq:fold-change-direction}\\
n &\sim& \mathcal{N}(9,1)
\end{eqnarray*}

Procedure

Step 1: Simulate one single-subject dataset, which contains \(p \%\) DEG.

Step 2: Conduct iDEG, edgeR1, DESeq2, and DEGseq3.

Step 3: Compute an F1 score for each method,

\begin{equation*}
F_{1} = \frac{2\times Precision \times Recall}{Precision + Recall}
\end{equation*}

Step 4: Repeat Step1-Step3 for 1000 times

Step 5: Calculate the arithmetic mean and standard deviation of the 1000 \(F_{1}\) resulted from each method.

Step 6: Change the value of \(p\), repeat Step 1-Step 5

1. Robinson, M. D. et. al., 2010, Bioinformatics;  2. Anders, S. et. al., 2010,  Genome biology ;
 3. Wang, L. et al., 2009, Bioinformatics

Method evaluation

Method evaluation

<colgroup>
<col  class="org-right" />

<col  class="org-left" />

<col  class="org-left" />

<col  class="org-left" />

<col  class="org-left" />

<col  class="org-left" />

<col  class="org-left" />
</colgroup>

DEG%
Method
Precision
Recall(TPR)
FPR
F1
Predictions

5%
iDEG
0.93 (1.6e-02)
0.679 (2.5e-02)
0.003 (7.2e-04)
0.784 (1.5e-02)
730.482 (3.4e+01)

edgeR
0.39 (8.4e-03)
0.948 (7.1e-03)
0.078 (2.8e-03)
0.552 (8.6e-03)
2432.95 (5.4e+01)

DESeq
0.999 (2.1e-03)
0.152 (3.8e-02)
0 (1.8e-05)
0.262 (5.8e-02)
152.45 (3.8e+01)

DEGseq
0.086 (6.7e-04)
0.985 (3.9e-03)
0.549 (3.9e-03)
0.159 (1.2e-03)
11408.61 (7.4e+01)

10%
iDEG
0.945 (1.1e-02)
0.708 (2.2e-02)
0.005 (1.1e-03)
0.809 (1.2e-02)
1500.32 (5.9e+01)

edgeR
0.447 (6.2e-03)
0.96 (4.3e-03)
0.132 (3.3e-03)
0.61 (6.0e-03)
4296.19 (6.0e+01)

DESeq
1 (0.0e+00)
0 (5.2e-04)
0 (0.0e+00)
0.002 (1.4e-03)
0.44 (1.0e+00)

DEGseq
0.165 (1.1e-03)
0.986 (2.5e-03)
0.556 (4.2e-03)
0.282 (1.6e-03)
11974.99 (7.6e+01)

15%
iDEG
0.953 (7.0e-03)
0.746 (1.6e-02)
0.006 (1.1e-03)
0.837 (9.1e-03)
2348.99 (5.8e+01)

edgeR
0.537 (5.7e-03)
0.964 (3.7e-03)
0.147 (3.4e-03)
0.69 (4.8e-03)
5384.34 (5.9e+01)

DESeq
1 (NA)
0 (3.3e-05)
0 (0.0e+00)
0.001 (NA)
0.01 (1.0e-01)

DEGseq
0.235 (1.4e-03)
0.986 (2.1e-03)
0.565 (4.2e-03)
0.38 (1.9e-03)
12562.45 (7.3e+01)

20%
iDEG
0.962 (4.6e-03)
0.763 (1.3e-02)
0.008 (1.0e-03)
0.851 (7.8e-03)
3175 (6.4e+01)

edgeR
0.602 (5.7e-03)
0.966 (2.8e-03)
0.16 (3.9e-03)
0.742 (4.4e-03)
6418.81 (6.4e+01)

DESeq
NaN (NA)
0 (0.0e+00)
0 (0.0e+00)
NaN (NA)
0 (0.0e+00)

DEGseq
0.299 (1.6e-03)
0.986 (2.0e-03)
0.577 (4.2e-03)
0.459 (1.9e-03)
13179.58 (6.8e+01)

  Cont'd

Although the Recall/TPR and number of precisions of iDEG are lower than edgeR, iDEG has high precision and low FPR across all percentages of DEG. These operating characteristics of iDEG may be preferable in large-scale inference, like RNA-Seq analysis, where investigators examine tens of thousands of genes in a high-throughput manner.

Sensitivity Analysis

Our experience indicates that without making assumptions on RNA-Seq data, it is difficult to construct suitable statistical inferences for a single-subject dataset. Nonetheless we test the two main assumptions we make:

The value of dispersion parameter is a function of expression mean.

The majority of the genes are null genes.

Sensitivity Analysis

Draw  dispersion parameter \(\delta_{g}\) from a uniform distribution \(\text{unif}(0.001, 0.1)\).

Sensitivity Analysis

Simulate single-subject datasets with a series of percentages of DEG.

Real data analysis

Data

iDEG result

Some interesting genes

Data

A transcriptome of tumor sample and a transcriptome of surrounding healthy sample of an African American woman with Triple negative breast cancer (TNBC).

TNBC is a subtype of breast cancer that has poor prognosis and considerable heterogeneity. It disproportionately affects women with African origin (Dietze et al., 2015). Personalized treatment may be successful for an African American TNBC patient if one could discover a set of her specific DEG and match some of these DEG to the targets of a therapeutic drug.

iDEG result

Table 2: The 10 top-hit (smallest local fdr) differentially expressed genes.

<colgroup>
<col  class="org-left" />

<col  class="org-right" />

<col  class="org-right" />
</colgroup>

Gene
local_fdr
Z

ADIPOQ
2.85e-34
-11.17

PLA2G2A
2.85e-34
-11.65

PI16
1.15e-33
-10.78

LEP
2.25e-33
-10.70

SFTPB
1.44e-32
-10.59

IL33
4.24e-31
-10.36

TUSC5
6.74e-31
-10.32

CSF3
2.89e-29
-10.04

COL6A6
3.24e-29
-10.04

CCL21
1.99e-28
-9.90

…
…
…

Some interesting genes

ADIPOQ & LEP: Adiponectin (gene product of gene ADIPOQ) and leptin (gene product of LEP) are considered as mediators for the association of breast cancer with obesity, which is a major risk factor for breast cancer (Nalabolu et al., 2014; Grossmann et al., 2010).

PLA2G2A: Although PLA2G2A has not been extensively studied for breast cancer, many studies have shown that it inhibits invasion and metastasis of gastric and colon cancer (Ganesan et al., 2008; Movahedian et al., 2016; Fijneman et al., 2009) and may predict survival (Xing et al., 2011).

TUSC5: Bubnov et al. (2012) has demonstrated the down-regulation of TUSC5 induced by DNA methylation in breast cancer. In contrast to mutated genes, DNA methylation is reversible.

Take home message

We developed a new and effective method to identify differentially expressed genes from two transcriptomes of a single patient.

Acknowledgements

 Helen Hao Zhang

 Yves A. Lussier

 Haiquan Li

 Joanne Berghout

 Grant Schissler

 Yuan Shang

 spa

redpajama_set_name: RedPajamaGithub


text:
Population by Country of Birth
Net Migration Statistics
About MWUK
Donate to Migration Watch UK
20 Bogus Arguments
10 Key Points on Immigration
250,000 More Homes Needed For Immigrants
Housing, Population
The higher population projections published by the ONS last week have implications for the number of new homes required to house future immigrants to Britain.
The government's projections of future households are calculated largely on the basis of the population projections. The most recent set were published in November 2010 (based on the 2008 based population projections) and are an important part of the evidence base for assessing future housing demand.
The 2008 household projections showed a 27% increase between 2008 and 2033 with an average annual increase of 232,000 households. However, if there had been no net migration the increase would have been only 149,000 a year – so about 83,000 households a year, on average, were expected to result from net migration; that is about 2,075,000 over the period.
The details of international migration to England are not yet available but an estimate based on the difference between net migration into the UK in the 2010 projection compared with the 2008 projection gives a difference between the two of 569,000 over the next 25 years. This implies that net migration into the UK is now assumed to be some 12.5% higher than in the previous population projections. Multiplying this into the additional household numbers (2,081,000), which are projected solely as a result of migration, in the 2010 household projections, gives an additional 260,000 homes required over the 25 years to 2034/5.
Commenting, Sir Andrew Green, Chairman of Migration Watch UK said "This is a further indication of the extent of pressure on housing that stems from the present massive levels of immigration. It can only add to the pressures on our countryside and especially the green belt."
1 The 2010 Household Projections are at:
http://www.communities.gov.uk/documents/statistics/pdf/1780763.pdf
2 The latest population projections are at:
http://www.ons.gov.uk/ons/dcp171778_235886.pdf
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Encyclopedia > Historical novel
A genre popularized in the 19th century by artists classified as Romantics, historical fiction must be distinguished from the the fiction portion of the genre of alternate history. A historical novel is a novel in which the story is set among historical events or, more generally, where the time the action takes place in predates the time of the first publication. Sir Walter Scott is usually considered the first to have used this technique, in his novels of Scottish history. Historical fiction may center on historical or fictional characters, but usually represents an honest attempt based on considerable research (or at least serious reading) to tell a story set in the historical past as understood by the author's contemporaries. Those historical settings may not stand up to the increased knowledge of later historians.
Sir Walter Scott's 1820 novel Ivanhoe is an early example, as is Victor Hugo's The Hunchback of Notre Dame (1831).
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Historical fiction can serve many purposes, such as satire. George Macdonald Fraser[?]'s dashing character Harry Paget Flashman is an example of satirical historical fiction.
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Under the name William Irish[?], Cornell Woolrich published Waltz into Darkness[?] (1947), which is set in New Orleans in 1880. Interestingly, in both filmed versions -- Fran�ois Truffaut's La Sir�ne du Mississippi (Mississippi Mermaid[?], 1969) and Michael Cristofer[?]'s Original Sin[?] (2001) -- the action takes place at a later point in time (and also somewhere else, for that matter).
T.C. Boyle's The Road to Wellville[?] (1993) narrates the story of Dr. John Harvey Kellogg[?], the inventor of the cornflake, and his Battle Creek Sanitarium. It is set in 1907.
Kazuo Ishiguro's novel The Remains of the Day (1989) is set in 1956. Flashbacks explain to the reader the dubious history of (fictitious) Darlington Hall in the 1930s and its association with Nazi Germany.
Patrick Redmond[?]'s The Wishing Game[?] (1999) is a thrilling depiction of life in a strict and uncanny boarding school in rural Norfolk in the 1950s.
Julie Myerson[?]'s novel Laura Blundy (2000) is set in Victorian London.
Jonathan Coe's novel The Rotters' Club[?] (2001) is an evocation of 1970s Britain.
For more examples, see list of historical novels.
See also historical whodunnit; family saga.
... dumped 2003-03-17 with ...


text:
This Book of Memories memorial website is designed to be a permanent tribute paying tribute to the life and memory of Dennis David. It allows family and friends a place to re-visit, interact with each other, share and enhance this tribute for future generations. We are both pleased and proud to provide the Book of Memories to the families of our community.
Dennis M.
Lady Lake, Florida
Obituary for Dennis M. David
Dennis David, 86, of The Villages, Florida, passed away at his home on November 25, 2020, after a long battle with kidney disease. He was born in Evanston Illinois on October 12, 1934.
He enlisted in the United States Army and served as a Corporal for three years. He joined the Dade Country Metro Firefighters where he became a lieutenant and served for 34 years retiring in 1995. Dennis Loved sports!! He played Army football then Semi-Pro football for Miami. He won a State championship in racquetball and loved to play softball. He also spent a lot of time shooting pool. He was an avid spear fisherman, a lobster diver and deep-sea fisherman.
Dennis is survived by his wife Sharon of 56 years, his son Robert and his daughter Debbie. His daughter in-law Sylvia and his grandchildren Niki and Rachel.
He will be missed by all that knew him.
The funeral will be held at St. Vincent DePaul Catholic church on Thursday, December 3, 2020 at 1:00 PM.
Arrangements entrusted to Beyers Funeral Home and Crematory, Lady Lake, FL. Online condolences may be left at www.BeyersFuneralHome.com
To send flowers to the family or plant a tree in memory of Dennis M. David, please visit our Heartfelt Sympathies Store.
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Lady Lake, Florida, United States


text:
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Subscribe and be informed on our latest logistics trivia quiz, blogs and news.
Which group first used boats on polar waters?
Vikings for Greenland expansion
North Russians' seaside settlers, or Pomors
Indigenous Arctic people
The indigenous Arctic people used small, light weight kayaks that carried the boat over the ice.
The right answer is the Indigenous Arctic people. They used small, light weight kayaks that carried the boat over the ice.
In 1837, a 51-meter (167 ft.) wooden steam-powered ice ship, designed by Vandusen & Birelyn, was built for which city?
The paddle steamer boat named, City Ice Boat No. 1, powered by two 250-horsepower steam engines, was reinforced with iron coverings.
The right answer is Philadelphia. The paddle steamer boat named, City Ice Boat No. 1, powered by two 250-horsepower steam engines, was reinforced with iron coverings.
The first diesel-electric icebreaker ship was a 4,330-ton Swedish icebreaker named When was this the vessel built?
At 9,000 hp, the ship remained the most powerful Swedish icebreaker until 1957.
The right answer is 1933. At 9,000 hp, the ship remained the most powerful Swedish icebreaker until 1957.
Arktika, a nuclear-powered icebreaker, was the first surface ship to reach the North Pole. Who built the vessel?
The ship reached the North Pole on August 17, 1977.
The right answer is Russia. The ship reached the North Pole on August 17, 1977.
True or False: Icebreaker vessels are strengthened for navigation in ice but are not powerful enough to manage ice by themselves.
The main function of icebreakers is to escort ships through ice-covered bodies of water.
The right answer is true. The main function of icebreakers is to escort ships through ice-covered bodies of water.
Three main traits of icebreaker ships or boats include: an ice-clearing shape, the power to push through sea ice and:
A drill
A navigator
A strengthened hull
The most reinforced areas in the hull of a ship are the bow, which experiences the highest ice pressure, and around the waterline.
The right answer is a strengthened hull. The most reinforced areas in the hull of a ship are the bow, which experiences the highest ice pressure, and around the waterline.
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text:
Q: How to parallelize correctly this program using OpenMP I'm in the process of learning parallelize concepts using OpenMP. So I have this program about interpolation and I made a try parallelizing this program, but I want to know if this is the correct form of doing this.
This is the program:
Function 'main' demonstrates the polynomial interpolation function by generating some test points and then calling 'polint' with a
 value of x between two of the test points.
Polynomial Interpolation
This program demonstrates a function that performs polynomial
interpolation. The function is taken from "Numerical Recipes
in C", Second Edition, by William H. Press, Saul A. Teukolsky,
William T. Vetterling, and Brian P. Flannery.
#include<math.h>
#include<stdlib.h>
#include<stdio.h>
#include<openmp.h>
#define N 20
#define X 14.5
int main (intargc, char *argv[]) {
double x, y, dy;
double *xa, *ya;
int i;
xa = vector (1, N); ya = vector (1, N);
/* Initialize xa's and ya's */
for (i = 1; i<= N; i++) {
    init (i, &xa[i], &ya[i]);
    printf ("f(%4.2f) = %13.11f\n", xa[i], ya[i]);
}
/* Interpolate polynomial at X */
polint (xa, ya, N, X, &y, &dy);
printf ("\nf(%6.3f) = %13.11f with error bound %13.11f\n", X, y, fabs(dy));
free_vector (xa, 1, N); free_vector (ya, 1, N); return 0;

}
Functions 'sign' and 'init' are used to initialize the x and y vectors holding known values of the function.
int sign (int j)
{
    if (j % 2 == 0) return 1;
    else return -1;
}
void init(inti, double *x, double *y) {
    // int j;
    *x = (double) i;
    *y = sin(i);
}

Function 'polint' performs a polynomial interpolation
void polint (double xa[], double ya[], int n, double x, double *y,     double *dy) {
inti, m, ns=1;
doubleden,dif,dift,ho,hp,w;
double *c, *d;
dif = fabs(x-xa[1]); c = vector(1,n);
d = vector(1,n);
#pragma omp parallel
{
    #pragma omp for
    for (i=1; i<= n; i++)
    {
        #pragma section
        dift = fabs (x - xa[i]);
        #pragma omp simple
        {
            if (dift<dif)
            {
                ns = i;
                dif = dift;
            }
        }
        c[i] = ya[i];
        d[i] = ya[i];
    }
}
*y = ya[ns--];
#pragma omp paralel
{
    #pragma for reduction(/: den)
    shared(m, n)
    for (m = 1; m < n; m++)
    {
        for (i = 1; i<= n-m; i++)
        {
            ho = xa[i] - x;
            hp = xa[i+m] - x;
            w = c[i+1] - d[i]; den = ho - hp;
            den = w / den;
            d[i] = hp * den;
            c[i] = ho * den;
        }
        #pragma omp section
        *y += (*dy=(2*ns < (n-m) ? c[ns+1] : d[ns--]));
    }
    #pragma omp section
    free_vector (d, 1, n); free_vector (c, 1, n); }
  }

Function 'free_vector' is used to free up memory allocated with function 'vector'
void free_vector(double *v, long nl, long nh) {
    free ((char *) (v+nl-1));
}

Function 'vector' is used to allocate vectors with subscript range v[nl..nh]
double *vector (long nl, long nh) {
    double *v;
    v = (double *) malloc(((nh-nl+2)*sizeof(double))); return v-nl+1;
}

redpajama_set_name: RedPajamaStackExchange


text:
Q: How to remove specific parts of XML string with XSL I have following XML document:
    <mail>
        <body> Dear XY,
here are some random information as a placeholder.
==========================================
Fruit_Type: apple
Vagetable_Amount: potato
Animal_Counter: two dogs
==========================================

        </body>
    </mail>

And I need to shorten the body string to this form:
    <mail>
        <body>
            Fruit_Type: apple
            Vagetable_Amount: potato
            Animal_Counter: two dogs
        </body>
    </mail>

Do you have any ideas how to do this?

A: You could try something like:
XSLT 1.0
<xsl:stylesheet version="1.0"
xmlns:xsl="http://www.w3.org/1999/XSL/Transform">
<xsl:output method="xml" version="1.0" encoding="UTF-8" indent="yes"/>
<xsl:strip-space elements="*"/>

<!-- identity transform -->
<xsl:template match="@*|node()">
    <xsl:copy>
        <xsl:apply-templates select="@*|node()"/>
    </xsl:copy>
</xsl:template>

<xsl:template match="body">
    <xsl:copy>
        <xsl:value-of select="substring-before(substring-after(., '=====
'), '
=====')"/>
    </xsl:copy>
</xsl:template>

</xsl:stylesheet>

Added:
To indent the result by a tab, you could do:
<xsl:template match="body">
    <xsl:copy>
        <xsl:for-each select="tokenize(substring-before(substring-after(., '=====
'), '
====='), '
')">
            <xsl:text>
	</xsl:text>
            <xsl:value-of select="." />
        </xsl:for-each>
    </xsl:copy>
</xsl:template>

provided your processor supports XSLT 2.0.


text:
Chen Yuanyuan (förenklad kinesiska: 陈圆圆, traditionell kinesiska: 陳圓圓), född 1625, död 1681, var en kinesisk yiji, skådespelare och operasångerska.

Chen Yuanyuan tillhörde en fattig familj och blev yiji i Suzhou efter sin fars död. Området var känt för sina yiji, och hon tillhörde en av de mest berömda vid sidan av Dong Xiaowan, Li Xiangjun och Bian Yujing. Chen Yuanyuan var särskilt känd för sin talang inom sång och skådespel, och hon deltog ofta som skådespelare och sångare i traktens operaföreställningar.

1640 utsattes hon för ett kidnappningsförsök av Tian Hungyu, far till kejsarens favoritkonkubin Tian. Hon bad då Mao Xiang, känd som en av "De fyra unga mästarna" och för att samla ett stall av yiji som konkubiner i syfte att låta dem fokusera på sina konstnärstalanger, att gifta sig med henne. Han avböjde, och 1642 köptes Chen Yuanyuan av Tianfamiljen. Efter ett misslyckat räddningsförsök av hennes beundrare blev hon sångerska hos Tianfamiljen.

Efter Tian Hungyus död 1643 köptes hon av militärbefälhavaren Wu Sangui. Under Li Zichengs uppror 1644 tillfångatogs Wu Sanguis far av Li Zicheng, som torterade honom tills han avslöjade var Chen Yuanyuan fanns. Hon kidnappades sedan av Li Zicheng, något som fick Wu Sangui att avböja en allians med Li Zicheng och i stället förena sig med manchuerna. När Li Zicheng hade besegrats, levde hon sedan i Wu Sanguis hushåll i Yunnan.

Chen Yuanyuan trivdes inte hos Wu Sangui och hans svartsjuka hustru, och begärde slutligen att få separera och gå i buddhistkloster. Wu Sangui lät då uppföra Anfu-trädgården åt henne i Yunnan, där hon bosatte sig och ägnade sig åt buddhismen. Hon gick dock aldrig in i något regelrätt buddhistkloster. Hon avrådde utan framgång Wu Sangui från att göra uppror 1673. När manchuerna intog Yunnan 1681, begick flera anhöriga till Wu Sangui självmord. Chen Yuanyuan ska ha varit en av dem. Enligt vissa legender ska hon ha svultit sig ihjäl, enligt andra dränkt sig i en liljedamm, men det troligaste är att hon hängde sig.

Källor

 Lily Xiao Hong Lee,Clara Lau,A.D. Stefanowska: Biographical Dictionary of Chinese Women: v. 1: The Qing Period, 1644-1911

Kvinnor
Födda 1625
Avlidna 1681
WP:Projekt Kina
Personer i Kina under 1600-talet
Kinesiska kurtisaner
Sångare under 1600-talet

redpajama_set_name: RedPajamaWikipedia


text:
Müpa Budapest (der ehemalige Palast der Künste, ungarisch Művészetek Palotája – MÜPA) ist eine kulturelle Einrichtung in Budapest.

Das Gebäude bietet Raum für drei Kunstrichtungen: Musik, bildende Kunst und Theater. Die Ausstellungsräume, der Konzertsaal und der Theatersaal funktionieren unabhängig voneinander.

Lage und Bau

Das Gebäude befindet sich am Donauufer auf der Pester Seite der Lágymányos-Brücke, einem ehemals vernachlässigtem Stadtgebiet. Die Grundfläche des Palasts der Künste nimmt 10.000 m2 des sich über 64.000 m2 erstreckenden Geländes ein, wo sich auch das Nationaltheater befindet. Nach einer dreijährigen Bauzeit wurde der Palast der Künste am 14. März 2005 eröffnet.

Die äußere Erscheinung zeichnet sich durch einfache Linienführung, das Fehlen von ausschmückenden Elementen sowie die mächtige, zusammenhängende Glasfront aus. Die weitläufigen inneren Räumlichkeiten sind überschaubar. Zum Bau wurden natürliche Materialien verwendet. Der Gebäudeentwurf stammt hauptsächlich von Gábor Zoboki (Zoboki, Demeter és Társaik Építésziroda, "Architektenbüro Zoboki, Demeter und Co.").

Die Gebäudeeinheiten und ihre Funktionen
Das Bauwerk bietet den Ansprüchen moderner Kunst Darstellungsmöglichkeiten in multifunktionellen Räumlichkeiten. Es besteht aus drei Hauptflügeln. Den zentralen Teil macht der Bartók Béla Nemzeti Hangversenyterem ("Nationaler Béla Bartók-Konzertsaal") aus. Im östlichen Flügel befindet sich das Fesztivál Színház ("Festival-Theater"). Der Westflügel beherbergt Ausstellungsräume und den Veranstaltungssaal des Ludwig Múzeums. Die drei Gebäudeeinheiten sind durch die gemeinsame Glasfassade verbunden, die sich in Richtung des Nationaltheaters hin öffnet.

Der Palast der Künste ist dauerhafter Sitz des Nemzeti Filharmonikus Zenekar, Énekkar és Kottatár (Nationalen Philharmonischen Orchesters, Chors und Notenarchivs), des Ludwig Múzeums und des Nemzeti Táncszínház ("Nationalen Tanztheaters").

 Der Nationale Béla Bartók-Konzertsaal ist aus architektonischer Sicht der dominante Gebäudeteil. Er bietet 1699 Besuchern Platz, davon sind 1563 Sitz- und 136 Stehplätze. Die Akustik sowie die technische Ausstattung entsprechen den modernsten Konzertsälen in Europa. Die akustische Ausarbeitung wurde von der US-amerikanischen Firma Russell Johnsons durchgeführt. Die Orgel wurde im Jahr 2006 fertiggestellt. Sie ist ein Gemeinschaftswerk der Pécsi Orgonaépítő Kft. ("Pécser Orgelbauer GmbH") und der deutschen Firma Mühleisen. Das große Werk hat 92 Register auf fünf Manualen und Pedal. Neben den ungarischen Philharmonikern treten auch weitere national und international bedeutende Künstler und Orchester auf.
 Das Festival-Theater nimmt den östlichen Flügel ein. Die Fläche der Bühne umfasst 750 m2. Die Zahl der Sitzplätze beträgt 452. Mit seiner Größe und technischen Ausstattung gehört er zu den modernsten Theatersälen und ist Sitz des "Nationalen Tanztheaters".
 Das Ludwig Kortárs Művészeti Múzeum ("Ludwig-Museum zeitgenössischer Kunst") befindet sich an der Donauseite. Der erste Stock ist Ausstellungsfläche. In diesem Flügel befinden sich auch der Präsentations- und Veranstaltungssaal. In den hellen Räumen des dritten Stockwerks ist die ständige Ausstellung zu finden. Weiterhin gibt es für die Museumsbesucher interaktive Ausstellungsräume, Medienecken, eine Bibliothek und Möglichkeiten der Kinderbetreuung.

Für die Organisation des Programms ist die durch das Nemzeti Kulturális Örökség Minisztériuma ("Ministerium für nationales kulturelles Erbe") eingesetzte Gesellschaft zuständig.

Im Jahr 2006 gewann der Palast der Künste den Prix d'Excellence der FIABCI (Nemzetközi Ingatlanszakmai Szövetség, "Internationale Immobiliengesellschaft") in der Kategorie "großes öffentliches Gebäude". Die Plakette der Auszeichnung befindet sich in der Vorhalle.

Finanzierung
Der Palast der Künste ist die erste Public Private Partnership- Konstruktion in Ungarn. Der zwischen der Regierung unter Viktor Orbán geschlossene Vertrag mit der TriGránit-Gruppe, die mit dem Namen Sándor Démján, dem derzeit reichsten Unternehmer Ungarns, in Verbindung steht, wurde im Dezember 2001 ausgehandelt und im März 2002 unterzeichnet. Darin war vorgesehen, dass die Privatfirma die Kosten von 31,2 Milliarden Forint bereitstellt, die von der Regierung – teils in Form von Leasing – innerhalb von 10 Jahren mit Zinsen zurückgezahlt werden sollten. Bereits im selben Jahr musste der Betrag nach oben korrigiert werden. Die Regierung legte eine obere Grenze von 52 Milliarden Forint fest. 2005 wurde dieser Betrag unter Minister István Hiller auf 97,9 Milliarden Forint festgelegt und die Laufzeit auf 30 Jahre erweitert, damit die jährlich laufenden Zahlungen verringert werden konnten. Ein Regierungssprecher erklärte offiziell, dass die Summe erneut nicht für die vollständige Deckung der Kosten ausreicht. Der staatliche Rechnungshof stellte im Jahr 2007 fest, dass bereits die ersten Regierungspläne finanziell nicht gedeckt waren. Es wurden keine Marktuntersuchungen, Wirkungsanalysen oder Kostenvergleiche durchgeführt.

 * exklusive der Unterstützung des Philharmonischen Orchesters, des Ludwig Museums und des Tanztheaters

Einzelnachweise

Weblinks

Veranstaltungsstätte in Budapest
Museum in Budapest
Kunstmuseum (zeitgenössisch)
Kunstmuseum in Ungarn
Konzerthaus
Ungarn
Wikipedia:PuB/Bautyp
IX. Budapester Bezirk
Gegründet 2005
Musik (Budapest)
Theater (Ungarn)


Have you ever wanted to have your own slice of Platte River Frontage? This is a great opportunity to do so with a property that has had a lot of thought put into it. It has been partially developed, and is ready for you to make it into your own. Located just South of the I 80 exit at Shelton, the property has some extremely scenic views. It includes 18 acres that consists of Platte River accretion, two small ponds, 5-6 acres of wooded area, a nice shelter belt and an open grass meadow. This property also has a large retaining wall put in place along with much of the dirt work completed to build a raised home or cabin, which would allow a house to sit above the 100 year flood plain. There are two new wells already on site. Also, depending on the buyers wishes there is a building approximately 18'x40' that can be left with the property or removed by the seller.
Another highlight of this property is that it has been surveyed and divided into four separate lots that can be utilized all as one tract, or divided and sold off into separate tracts. The North end of the property can be used as a commercial property. The current property owner has already surveyed and zoned it correctly with the county.
This property has great investment potential with its' scenic views, river frontage, wildlife, ponds, a building site, two wells, and an established shelter belt.


I am an experienced engineer working for MasterCard in Dublin, Ireland. I have a background in development and systems engineering and love working with technology.
How do I put objects in an NSArray into an NSSet?
How to parse hundred html source code files in shell?
How can I setup a Mail Transfer Agent?
How do I delete all objects from my persistent store in Core Data?
How can I list and edit all defined aliases in Terminal?
Is it possible to use an iPhone without a SIM card as an iPod touch?
How do you erase pictures from the Photo Stream album on an iPhone running iOS 5?
Why does my Mac Pro have two ethernet ports on the back of the computer?
How does a quartz crystal work?
Is data transmitted over 3G secure?
Where are Apple's default desktop images stored?
How do I check the exposure of my machine to the internet?
How can I reformat my hard-drive?
Do all magsafe power ports have the same form factor?
Why can't I disable my iPhone's (iOS 5) new mail sound?
How can I force iPhone to resync contacts from server?
Can I turn off IPv4 and just use IPv6 on my Mac?
Can the King be attacked by a pinned piece?


text:
The TMC Library
McGovern Historical Center
ABCC Collections
Radiation Effects & Events Collections
Archives & Rare Book Collections for The TMC Library, McGovern Historical Center
Professional society, 1 results 1
Paper, 1 results 1
printed materials (object genre), 1 results 1
Minutes (administrative records), 1 results 1
rosters, 1 results 1
Only top-level descriptions Professional society
Repository Library of Congress Name Authority File Library of Congress Name Authority File Library of Congress Name Authority File Library of Congress Name Authority File Library of Congress Name Authority File Library of Congress Name Authority File Library of Congress Name Authority File Library of Congress Name Authority File Library of Congress Name Authority File Library of Congress Name Authority File Library of Congress Name Authority File Library of Congress Name Authority File Library of Congress Name Authority File McGovern Historical Center, Texas Medical Center Library RESTRICTED-McGovern Historical Center, Texas Medical Center Library
Level of description Book Collection File Fonds Item Part Series Subfonds Subseries
Texas Society for Child Psychiatry records
The Texas Society for Child Psychiatry records contains correspondence, minutes for years 1966-1984, roster of mailing list from 1972 to 1982, and other papers and printed materials relating to the Texas Society for Child Psychiatry.
Subjects: Psychiatry
Texas Society for Child Psychiatry


I finally got some Biostrip 20 and, as I needed a video to also try out my new video editing software, I thought I'd do a review.
I try to really put the product through its paces, using metal, plastic, resin and pre-painted plastic minis to see what works and what doesn't.
Noooooooooooooooo, you mad man! Haven't watched the video (at work) but I'm going to wager that did not end well... certainly didn't for me, luckily it was just a resin base.
No, it went fine. Biostrip 20 seems absolutely fine for the resin mini, although it takes a more gentle hand and more patience than plastic or metal.
Just watched the vid, interesting, when i used it on resin it ate it away and left the surface pitted and warped. It confused me since Biostrip is completely non-toxic etc. I leave it on for an hour though not 15 minutes and all the paint basically just sloughs off.
As for the pre-paints the magic bullet is acetone (mostly), the proper 99% stuff. It works on Heroclix certainly and Rackham stuff though with the latter you need to be careful as some of Rackham's bits (the weapons mostly) were hard plastic which will melt in acetone.
I have used Biostrip for a while and have not had a problem with plastics or resin miniatures.
I brush the paste onto the figure then pop it into a ziplock or sealable figure bag to stop it drying out (as things tend to do rapidly here). Left for about an hour before rubbing with a soft brush, but one with much shorter bristle length than you used in the video, then all cleaned up in a bowl of water.
If the Biostrip dries on the figure it ceases to work and needs a new application.


As a long-time headache sufferer, I've had quite a few different headache diagnoses attached to my chart. Tension headaches, sinus headaches, migraine headaches, and menstrual migraines are the four that come to my head right away, although I know that there are more.
When I was assigned to write this article about confusional migraines, I was stumped. A new kind of migraine, perhaps? Was this a type of headache that actually missed me?
As it turns out — no, this is not a migraine that missed me. It is most common in the pediatric population and is an acute headache as opposed to a chronic headache.
It is considered to be a rare migraine that resolves rapidly with the proper treatment.
Migraines in general are fairly common in the pediatric population. Pre-puberty, they are more common in boys, while after puberty they are more common in girls.
ACM accounts for one out of five migraines, while the other types of migraines in the pediatric population include benign paroxysmal torticollis, benign paroxysmal vertigo, abdominal migraines, cyclic vomiting and acephalgic migraines.
ACM in particular occurs in 0.04 percent of the pediatric migraine series, occurring more frequently in males. They most commonly occur in the five to 16 year old age group.
Most children who have ACM also have a family history of migraines (77 to 100 percent) and also a personal history of migraines (20 to 53 percent).
Typically, the attack lasts anywhere from 30 minutes to 24 hours. ACM has a strong association with head trauma.
The AAP notes that ACM is a diagnosis of exclusion because the symptoms tend to align with other diagnoses. Aside from the symptoms listed above, physical examination is generally normal.
Treatment is initially aimed eliminating differential diagnoses, such as encephalitis, meningitis, seizures, toxin exposures, and metabolic exposures. To do so, this may include lab draws and diagnostic exams such as magnetic resonance imaging (MRIs), electroencephalogram (EEG) and computed tomography (CT).
Treatment for ACM is controversial there have been no controlled studies in the pediatric population, thus physicians typically use medications that have proven effective, such as medications used to treat seizures.
In a specific case study by the AAP, valproic acid (VPA), a medication used to treat seizures, was used intravenously in a 12-year-old girl who presented with ACM. After differential diagnoses were eliminated, and midazolam (a benzodiazepine) failed to improve symptoms, VPA was administered intravenously.
Her symptoms cleared within 30 minutes. She was asymptomatic for 24 hours in the inpatient setting and remained asymptomatic until her follow-up appointment, as was an EEG that was performed at the follow-up appointment.
Confusional migraines are unlike other migraines. They are acute and do not last long but may require emergency treatment to clear.
Their treatment is controversial at best and further research still need to be performed, although certain long-standing medication options do seem to be effective in treating ACM.


Generates and supplies electricity and natural gas to businesses and industries in North Carolina, South Carolina and Florida. Includes corporate overview, news, and economic development.
BellSouth - Principal provider of telephone services and a major south and southeast public utilities source of other telecommunications services (including internet) in south and southeast public utilities the southeastern states of Alabama, Florida, Georgia, Kentucky, south and southeast public utilities Louisiana, Mississippi, North and South Carolina, and Tennessee.
Duke Energy Corporation - Provides electricity to customers in North and South Carolina. Also provides natural gas to customers in the Northeast, Midwest, and Gulf Coast areas.
Entergy Corporation - Provides electricity to customers in Arkansas, Louisiana, Mississippi, south and southeast south and southeast and Texas.
Dominion Resources - Providing electricity to customers in Virginia and North south and southeast public utilities Carolina.
LG&E Energy Corp. - Provides natural gas and electricity for customers in public utilities Kentucky business and economy and Virginia.
Progress Energy - Generates and supplies electricity and natural gas to public utilities businesses and industries in North Carolina, South public utilities Carolina and Florida. Includes corporate overview, news, public utilities and economic development.
Pepco Energy Services - Provides energy and energy-related products to residential and business customers, from Connecticut to Florida.


text:
package streams.factories;

import streams.algebras.StreamAlg;
import streams.higher.App;
import streams.higher.Pull;

import java.util.NoSuchElementException;
import java.util.function.Function;
import java.util.function.Predicate;

/**
 * Authors:
 * Aggelos Biboudis (@biboudis)
 * Nick Palladinos (@NickPalladinos)
 */
public class ExecFusedPullFactory extends ExecPullFactory implements StreamAlg<Pull.t> {

    @Override
    public <T> App<Pull.t, T> filter(Predicate<T> filter, App<Pull.t, T> app) {
        Pull<T> self = Pull.prj(app);

        if (self instanceof FusibleFilterPull) {
            return ((FuseFilterPull<T>) self).compose(filter);
        } else {
            return new FusibleFilterPull<T>(self, filter);
        }
    }

    @Override
    public <T, R> App<Pull.t, R> map(Function<T, R> mapper, App<Pull.t, T> app) {
        Pull<T> self = Pull.prj(app);

        if (self instanceof FuseMapPull) {
            return ((FuseMapPull<T>) self).compose(mapper);
        } else {
            return new FusibleMapPull<>(self, mapper);
        }
    }

    interface FuseMapPull<T> extends Pull<T> {
        <S> Pull<S> compose(Function<T, S> other);
    }

    interface FuseFilterPull<T> extends Pull<T> {
        Pull<T> compose(Predicate<T> other);
    }

    class FusibleFilterPull<T> implements FuseFilterPull<T> {

        private final Pull<T> source;
        private final Predicate<T> predicate;
        T next = null;

        public FusibleFilterPull(Pull<T> source, Predicate<T> predicate) {
            this.source = source;
            this.predicate = predicate;
        }

        @Override
        public FusibleFilterPull<T> compose(Predicate<T> other) {
            return new FusibleFilterPull<>(source, other.and(predicate));
        }

        @Override
        public boolean hasNext() {
            while (source.hasNext()) {
                T current = source.next();
                if (predicate.test(current)) {
                    next = current;
                    return true;
                }
            }
            return false;
        }

        @Override
        public T next() {
            if (next != null || this.hasNext()) {
                T temp = this.next;
                this.next = null;
                return temp;
            }
            throw new NoSuchElementException();
        }
    }

    class FusibleMapPull<T, R> implements FuseMapPull<R> {

        private final Pull<T> source;
        private final Function<T, R> mapper;
        private R next = null;

        public FusibleMapPull(Pull<T> source, Function<T, R> mapper) {
            this.source = source;
            this.mapper = mapper;
        }

        @Override
        public <S> FuseMapPull<S> compose(Function<R, S> other) {
            return new FusibleMapPull<>(source, other.compose(mapper));
        }

        @Override
        public boolean hasNext() {
            while (source.hasNext()) {
                T current = source.next();
                next = mapper.apply(current);
                return true;
            }

            return false;
        }

        @Override
        public R next() {
            if (next != null || this.hasNext()) {
                R temp = this.next;
                this.next = null;
                return temp;
            }
            throw new NoSuchElementException();
        }
    }
}


text:
Home / Always a Commando: The Life of Singapore Army Pioneer Clarence Tan Book (Autographed)
Always a Commando: The Life of Singapore Army Pioneer Clarence Tan Book (Autographed)
Specially Autographed by Clarance Tan Himself
Best known for his role in helping to establish the Singapore Armed Forces Commando Formation and as the unit's first commanding officer, Lieutenant-Colonel (Retired) Clarence Tan was born on his family's rubber plantation, just ten months before the Japanese invasion of British Malaya in 1941. As with those of his generation, his life spans the dramatic, often tumultuous years of Singapore's evolution from a primarily rural British colony to the world class cosmopolis it is today. From leading a platoon during racial riots in Singapore to searching for communist insurgents and Indonesian infiltrators in the jungles of Malaysia during the Emergency and the Confrontation, LTC (Rtd) Tan was part of both the British and Malaysian armies before becoming a pioneer officer in Singapore's defence force. For as surely as there are makers of history, there are those too who are made by history. Always A Commando is at once a compelling chronicle of one man's life from kampong kid to red beret and a rich evocation of the country he served through turbulent and uncertain times.
Thomas A. Squire was born and raised in Wellington, New Zealand, where he met his wife, a Singaporean working in Wellington at the time. Upon following her back to Singapore, he immediately became fascinated with the history of his new home. It was conversations with his father-in-law, a retired army officer, about his life in Singapore that was the genesis of Always A Commando. A pilot and mathematician by training, a tech worker by trade, Thomas has lived in Singapore for more than twenty years.


text:
Smucker, Emmer Introduce Bipartisan VA Billing Accountability Act
Washington, D.C. – Continuing his record of working across the aisle towards commonsense solutions, U.S. Rep. Smucker (PA-16) teamed up with Reps. Collin Peterson (MN-07) and Tom Emmer (MN-06) to introduce legislation to relieve veterans of financial burdens caused by delays at the Department of Veterans Affairs (VA).
Pennsylvania's 16th Congressional District is home to more than 10,000 veterans. The bipartisan VA Billing Accountability Act sets forth specific and immediate billing requirements so our nation's veterans are not receiving unbilled co-payments for VA care from years past.
"Our nation's service men and women should not have to pay for delays or errors made by the VA," said Rep. Smucker. "They and their families have sacrificed so much in defense of our homeland. We should be doing all we can to make their transition to civilian life as easy as possible, and this bill will help bring more stability and financial security to their post-military lives. I am glad to join Reps. Peterson and Emmer in this bipartisan effort to advance commonsense legislation on behalf of veterans."
"I have heard from many veterans that have been billed by the VA and it's frustrating to hear their situation. This bill is intended to hold the VA accountable," said Rep. Peterson. "With this bill, I hope we can restore the faith to our veterans that they will receive the care they were promised without getting stuck with unexpected bills."
"The men and women who dedicate their lives to defend the safety and freedoms of this nation deserve nothing but the best once they return home," said Rep. Emmer. "It is our duty to make their lives easier, not more difficult and the VA Billing Accountability Act will help do just that. Through clearly defining timing and other VA billing requirements, we can bring more certainty and assurance to our nation's veterans after they've returned to their civilian lives. I am proud to work with Congressmen Smucker and Peterson on this legislation and look forward to working with our colleagues towards its passage."
The VA Billing Accountability Act authorizes the VA to waive the requirement that a veteran make co-payments for medication, hospital care, nursing home care, and medical services if:
an error committed by the VA or a VA employee was the cause of delaying copayments notification to the veteran; and
the veteran received such notification more than 120 days (18 months in the case of a non-VA facility) after the date on which the veteran received care or services
Additionally, this legislation grants authorizing power to the VA Secretary to get rid of the requirement that veterans make a co-payment if the VA does not abide by the billing timing mandates.
Permalink: https://emmer.house.gov/2017/4/smucker-emmer-introduce-bipartisan-va-billing-accountability-act