Shaving heads are surrounded with ComfortGlide rings, which have a special protective coating with skin gliding properties to shield your face from irritation. Series 6000 offers 5x better protection than a manual blade*. *Protects better against nicks and cuts than manual blades after a 21-day adjustment period.
72 self-sharpening SkinProtect blades gently capture hair, leaving your face smooth and comfortable.
Heads follow the curves of your face, even catching hair in hard-to-reach areas like the neck and jaw line.
Get a convenient dry shave or a more comfortable wet shave with gel or foam - even in the shower.
Activate the guard mode to adjust to a lower rotational speed for a more gentle shave.
Shave longer with every charge, thanks to a powerful and long-lasting Lithium-ion battery. You'll have 50 minutes of shaving time – that's about 17 shaves – on a one hour charge. This shaver only operates in cordless mode.
Shave longer with every charge, thanks to our powerful, long-lasting lithium-ion battery. A quick 5-minute charge provides enough power for one shave.
The intuitive display shows relevant information, enabling you to get the best performance out of your shaver: - 3-level Battery Indicator - Cleaning Indicator - Battery Low Indicator - Replacement Head Indicator - Travel Lock Indicator - Unplug for use indicator.
For best shaving performance, replace your shaving heads every 12 months. Use SH60 replacement heads, sold separately.


text:
Navy holds AI and cybersecurity contest with $150,000 in cash prizes
Yeoman 1st Class Caaleb Johnson-Burroughs, from Atlanta, reviews a ship instruction on his computer aboard the guided-missile destroyer USS Dewey. (U.S. Navy photo by Mass Communication Specialist 2nd Class Devin M. Langer/Released)
The Navy launched a competition this week for finding machine learning and artificial intelligence solutions for real-world cybersecurity challenges.
The challenge — dubbed the Artificial Intelligence Applications to Autonomous Cybersecurity Challenge (AI ATAC) — holds a $100,000 first place and $50,000 second place awards. It is open to all citizens and permanent residents, be they defense contractors, researchers, students or just technology-curious private citizens.
The contest is sponsored by Naval Information Warfare Systems Command (NAVWAR) and Program Executive Office for Command, Control, Communications, Computers and Intelligence (PEO C4I). It's a way to lower barriers for the private industry to work with the military. Contracting requires fine-tuned knowledge on the process and cybersecurity concerns, but with a contest, more people can participate than just the defense industrial base. The contest winnings pale in comparison to some of the multimillion- or billion-dollar contracts the military awards for cybersecurity.
"We are approaching innovation with disciplined urgency," NAVWAR Commander Rear Adm. Christian Becker said. "This prize challenge presents a unique opportunity to cast a wider net to get the best technology to the fleet faster."
The period for submission is open through Sept. 30 and winners will be announced in December. Entrants need to submit both an endpoint security solution and white paper.
"We believe by sponsoring AI ATAC we can quickly get new ideas about how we can
incorporate AI and ML into our cybersecurity tool bag," John Armantrout, a deputy program manager at PEO C4I, said.
artificial intelligence (AI), challenges, Cybersecurity, machine learning, Navy

redpajama_set_name: RedPajamaCommonCrawl


text:
module Prawnto
  module ActionViewMixin

  private
    def _prawnto_compile_setup(dsl_setup = false)
      compile_support = Prawnto::TemplateHandler::CompileSupport.new(controller)
      @prawnto_options = compile_support.options
    end

  end
end

redpajama_set_name: RedPajamaGithub


For years, athletes and bodybuilders have been using whey protein as their go-to supplement for losing weight, building muscle, and getting the essential nutrients our bodies need. Today, however, as more and more consumers strive to live healthier lifestyles, whey is also becoming the go-to ingredient for improving nutrition in everyday food and beverage applications.
Made using a natural production process that features zero chemical modifications, additives, preservatives, or antibiotics, whey protein is a natural protein source that can help food and beverage manufacturers replace high-fat ingredients, reduce fat and calories, and clean up labels with a single ingredient. It helps reduce the effects of aging, boosts metabolism, and even prevents strokes while serving as part of a well-balanced diet for both children and adults alike.
When compared to other leading non-meat protein sources (e.g., casein, soy, pea, and rice), whey is heads and shoulders above the rest in terms of protein quality and flavor, making it the ultimate ingredient for improving nutrition.


text:
Top 10 Kenyan Music Genre
By fadamana
Music has always held a special position in Kenya. Previously, traditional or cultural music was more dominant. However, this has been replaced by modern music. The new music either features a fusion of the old and new, or completely new music genres. The following are the 10 recommended Kenyan music you should listen to:
Here's Our List of Top 10 Kenyan Music Genre
1. Gospel
Kenya is one country where gospel music has gained a broad acceptance. Yea, gospel music is the most successful type of music in Kenya at the moment. It is receiving massive airplay from radio and television stations in the region. This has led to many gospel artists venturing into the scene. Some of the notable artists include "Jimmy Gait, Betty Bayo, Size 8, Holy Dave, Bahati, Hope Kid, Ruth Wamuyu, Lois Kim, and many others.
2. Genge
Genge is a form of music that originated from a specific location in the country's capital Nairobi. This music is representative of the people living on the eastern side of the city. It is associated with the "Calif" Record Label. Some of the artists in this stable you would fancy listening to include "Jua Kali, Q-tasi, Alahola, Nonini, P-Unit, and others.
See Also: 10 Evergreen Oromo Music You Should Listen To
3. Kapuka
Kapuka was also discovered within the same period as "Genge". It was a kind of show of might between the two genres. Although there are several production houses for this music, it was originally connected to the "Ogopa" Djs. Some "Kapuka" musicians include Nameless, Boomba Clan, Collo, Mustapha, Kendi, Marya, Avril, among many others.
READ 10 Coolest and Popular Eritrean Music
4. Ghetto Hip-Hop
Although this type of music was influenced by Western or American Hip-hop, it was localised to reflect the culture of the people specifically those living in the Kenyan ghettos. It has undergone a renaissance since its discovery almost two decades ago. The pioneers included "Kalamashaka" and "Ukoo Fulani". Current musicians include "Cannibal, Machizi, La balaa, Mau mau, and others.
libertythinkers.com
See Also: Love Messages, Cute Things to Say to your Girlfriend, Bible Verses About Love
5. Kenyan Rock
A person who appreciates rock may also find Kenyan rock quite ideal. Although rock in Kenya has not moved as fast as other forms of music, it is starting to receive some attention. There are only a few rock groups in Kenya with "Murfys flaw, Last years tragedy, Claymore project, and Parking lot grass" being most popular.
Most Popular Kenyan Music Genre
6. Afro Fusion
Afro fusion is basically a blending of African and western tunes. This music will include the use of African percussion as well as Western instruments. This will also apply to the vocals which will be reflective of both African and western music for instance Jazz, Rhythm and Blues, and pop. Popular music comes from artists such as "Mercy Myra, Eric Wainaina, Yunasi, Suzanne Owiyo, Atemi, and others.
READ 10 Popular Kenya Gospel Music Artists
See Also: 10 Coolest and Popular Eritrean Music
7. Benga
Benga is one of the oldest types of music in Kenya. It has been played for almost half a century and resembles the music from the Caribbean or Cuban region. The tunes and instrumentals have borrowed a leaf from Samba, and Rumba. Artists who perform in Benga include" Ken wa Maria, Tony Nyadundo, and the late D.O. Misiani".
8. Rap
Kenyan rap is among the fastest growing genres of music. Although it has been around for more than a decade, new and fresh talent is always been discovered. In actual fact, rap musicians are among the best performing artists.They include "Octopizzo, Rabbit, Bamboo, Abbas, Kaligraph, X-tatic, Muthoni the Drummer queen" among others.
9. Spoken Word
Spoken word has always raised eyebrows when it comes to music. Some view it as poetry, while others appreciate it as any other music. Spoken word performances have brought new ideas of providing entertainment. This includes collaborating with other musicians as well as adding instrumentals to the artistic performance. Music to watch out for includes that from "Jemedari, Number 8, Specifyd" and others.
10. Afro pop
Afropop also known as Kenyan pop is also among the oldest music in the country. It can be traced back over half a century. The music features acoustics from different cultures within Kenya as well as beyond. It will also be performed using traditional instruments. Notable artists comprise, Gidi, majimaji, them mushrooms, and many others.
Although the above list features the 10 recommended Kenyan music you should listen to, the music scene in Kenya has become very pulsating. This has led to new types of music coined based on regional settings such as taarab. There is music that originates from specific Kenyan ghettos such as genge, or ghetto rap. The age group also defines the kind of music, for instance Benga, or afro-pop.
Questions to Ask a Guy
Chemistry Jokes
Nicknames for Guys
fadamana
READ Emmy Kosgei - A Closer Look At Her Life, Daughter & Husband Anselm Madubuko
Just How Much Is Yemi Alade's Net Worth and How Did She Build Her Wealth
From "Johnny" to "True Love", Nigerian singer and songwriter Yemi Alade has been on an astronomical rise since she made her debut as a...
How Much Is Khaligraph Jones' Worth and What Does It Cost To Invite Him To a Show
Tyna - Modified date: January 4, 2021
Kenyan rapper Khaligraph Jones is estimated to have a net worth of Ksh 10.7 million (around $100,000). This impressive net worth has made him...
Is Priddy Ugly The Same Age As His Wife Bontle Modiselle? – Fun Facts About Their Love Story
Chacha - Modified date: December 29, 2020
Priddy Ugly is one of the relatively new faces that have come to stay in the music space of the South African entertainment industry...
A Breakdown of Okyeame Kwame's Net Worth and What He Spends it On
Steve - Modified date: December 25, 2020
Okyeame Kwame is an A-list rapper who has made a name for himself in the Ghanaian Music industry. Popularly known as Rap Doctor, he...
Octopizzo's Net Worth: How The Music Artist Makes And Spends His Money
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It goes without saying that people who have seen the hard part of life and struggled to survive, appreciate better when they come into...
Diamond Platnumz' Net Worth and How He Became The Richest Musician In Tanzania
Uju - Modified date: December 18, 2020
Africa as a continent has provided a fair play ground for its talented citizens who want to excel in both the sports and entertainment...


text:
The North American Review, Volume 58
geredigeerd door Jared Sparks, Edward Everett, James Russell Lowell, Henry Cabot Lodge
VOL. LVIII.
PUBLISHED BY OTIS, BROADERS, AND CO.,
No. 120 WASHINGTON STREET.
.N87 v.58
CAMBRIDGE:
METCALF, KEITH, AND NICHOLS,
PRINTERS TO THE UNIVERSITY.
No. CXXII.
I. GRISWOLD'S POETS AND POETRY OF AMERICA
The Poets and Poetry of America; with a His-
torical Introduction. By RUFUS W. GRISWOLD.
II. PALFREY'S LOWELL LECTURES ON THE EVIDENCES
OF CHRISTIANITY.
Lowell Lectures on the Evidences of Christianity.
By JOHN GORHAM PALFREY. With a Discourse on
the Life and Character of John Lowell, Jr. By
EDWARD EVERETT.
III. TRADE WITH THE HANSE TOWNS: THE GERMAN
TARIFF-LEAGUE
Ueber die Moeglichkeit eines zwischen dem
deutschen Zoll-Verein und den Vereinigten Staaten
von America abzuschliessenden Handels und Schiff-
fahrts-Vertrags. (On the Possibility of a direct
Treaty of Commerce and Navigation between the
States of the German Tariff-League and the United
States of America.)
2. Neuere Geschichte der Poetischen National-
Literatur der Deutschen, von G. G. Gervinus. (A
History of the Modern Poetical Literature of the
Germans. By G. G. GERVINUS.)
IV. GERVINUS'S HISTORY OF GERMAN POETRY . . . 79
1. Geschichte der Poetischen National-Literatur
der Deutschen, von G. G. GERVINUS. (A History
of the (Early) Poetical Literature of the Germans.
By G. G. GERVINUS.)
V. DEBTS OF THE STATES.
. . 109
1. State Stocks and Revenues, comprising Statis-
tical Tables of the Stocks, Debts, Expenditures, and
Revenues of each of the United States.
2. Report of the Joint Committee of the Senate
and House of Representatives of the State of Michi-
gan, on the Subject of the Five Million Loan Bonds.
February, 1843.
3. Message of Governor McNutt to the Legisla-
ture of the State of Mississippi. January, 1841.
4. Message of Governor Porter to the Legislature
of the State of Pennsylvania. January, 1843.
VI. PRESCOTT'S HISTORY OF The Conquest oF MEXICO 157
History of the Conquest of Mexico, with a Pre-
liminary View of the Ancient Mexican Civilization,
and the Life of the Conqueror, Hernando Cortés.
By WILLIAM H. PRESCOTT.
VII. SAM SLICK IN ENGLAND: CHANGE FOR AMERICAN
1. The Attaché; or Sam Slick in England. By
the Author of "The Clockmaker, or the Sayings
and doings of Sam Slick," &c.
2. Change for the American Notes: in Letters
from London to New York. By an American Lady.
IX. CRITICAL NOTICES.
VIII. CATALOGUE OF THE LIBRARY OF BROWN UNIVERSITY 227
A Catalogue of the Library of Brown Univer-
sity, in Providence, Rhode Island. With an Index
of Subjects.
1. Duer's Lectures on the Constitutional Juris-
prudence of the United States.
2. Champlin's Edition of Demosthenes on the
Crown.
5. Krebs's Guide for Writing Latin
NOTE TO ARTICLE IX. OF No. 121.
QUARTERLY LIST OF NEW PUBLICATIONS
3. Cushing's Report of Proceedings and Debates 243
4. An Introduction to Geometry
I. JAMES'S NOVELS
No. CXXIII.
The False Heir. By G. P. R. JAMES, Esq.
II. LOWELL'S POEMS
Poems, by JAMES RUSSELL LOWEll.
III. THE FOREST LANDS OF MAINE .
Report of the Land Agent of the Commonwealth
of Massachusetts, laid before the Legislature, Janu-
ary 10th, 1844. By GEORGE W. COFFIN.
IV. REDFIELD, Reid, Espy, anD LOOMIS ON THE THEO-
RY OF STORMS
1. Various Papers on Meteorology, and the Laws
of Storms, by W. C. REDFIEld.
2. An Attempt to develope the Law of Storms by
Means of Facts, arranged according to Place and
Time. By LIEUT. COLONEL W. REID, C. B., F. R. S.
3. The Philosophy of Storms. By JAMES P. Es-
PY, A. M.
4. On the Storm which was experienced through-
out the United States about the 20th of December,
1836. By ELIAS, LOOMIS.
V. THE RECENT CONTEST IN RHODE ISLAND
1. An Address to the People of Rhode Island, de-
livered in Newport, May 3d, 1843, in Presence of
the General Assembly. By WILLIAM G. GODDARD.
2. A Concise History of the Efforts to obtain an
Extension of Suffrage in Rhode Island, from the
Year 1811 to 1842. By JACOB Frieze.
3. The Affairs of Rhode Island: a Discourse de-
livered in Providence, May 22, 1842. By FRANCIS
WAYLAND.


Urban Yoga teaches advanced spiritual knowledge from the Bhagavad-gita and Srimad-bhagavatam and practices a form of devotional yoga called Krishna bhakti. This wisdom derives from the sacred and timeless hymns of the Vedas.
Urban Yoga is a branch of Gaudiya or Chaitanya Vaishnavism, a movement inaugurated by the celebrated teacher Chaitanya Mahaprabhu in the sixteenth century. Gaudiya Vaishnavism teaches advanced monotheism based on the theistic Vedanta of Ramanuja (12th c.), Madhva (13th c.), and Baladeva (18th c.), whose teachings are rooted in the Upanishads, the earliest philosophical texts of India.


I felt like showing some of the custom models that I've made recently. Feel free to reply with your own customs or questions about mine.
The teal truck behind S.C.Ruffey. Some of the Wiki writers are convinced that this is Rickety.
"Oliver's no use at all..."
I also made the non-express main line coaches from season 1. These had an ERTL release as "Old Coaches."
I didn't realize until after buying a brake coach kit that the brake coach in the TV series looks like a composite coach that was painted like a brake coach (kind of like Emily's coaches). Oh Well.
Well done on those customs! And since you made Fred Pelhay and Rickety, apparently the models of the Cargo Car and Blue Open Wagon were supposed to be those characters, and then they were cancelled.
Has anybody ever modified any of the old Hornby clockwork versions of the Tidmouth Milk tanker to make it say TAR or something else? Also, don't you find it to be just a big bummer that Hornby never went beyond Shell and Tidmouth Milk when they did their Hornby clockwork range?
Here is my latest: Victoria from the penultimate book of the RWS (as extended by Christopher Awdry).
I haven't decided on the order since Elsie and Victoria have never been depicted together. I've seen old photos of the Wisbech luggage van directly behind the tram, but not having Henrietta first seems odd.
What book chapter it is in? I can't seem to remember that when I reading. I do have the complete book series.
Victoria is in the book, Thomas and Victoria (the book has little to do with Thomas, but his name was put on most of Christopher Awdry's books for the sake of name recognition). Christopher Awdry's books are typically left out of RWS sets, and if you do have the Christopher Awdry collection, I believe that was actually published before Thomas and Victoria. She was added to Toby's train because Henrietta was becoming overcrowded and passengers were riding on her verandas, causing Toby to get in trouble with the police, much like Thomas before him. She is a former Furness Railway coach, which is why she is blue and white instead of orange like the other Ffarquhar branchline coaches.
Thanks for that wonderful information. I'll look to see about the new stories from Christopher.
Nice Fred model, mate. Your timing's decent; I made this version just a couple months ago.
Nice job with the face on your Fred. Did you mold it yourself? I've been making the faces on mine with paper eyes like Annie and Clarabel and the season 1 trucks. The large brackets on both ends of the 8 plank wagon (I followed the wiki that he is based on a fixed end 8-plank wagon) that I used to make Fred wound up making the face pretty difficult to apply. Making him dirty with coal dust was also a nice touch.
It took me a minute, but I can see that he repainted S.C.Ruffy's face, if not an entire S.C.Ruffey wagon.
It is indeed just a S.C. Ruffey model; never cared for Bachmann's lazily-made version of the character and decided to repurpose him for this.
I knew that there was something familiar about the face.
Well he really surprised me! I didn't notice it was the same car, but it was very detailed change of the mouth and eyebrows.
I checked Christopher's books. I don't have any of his works. I was surprised that some of the stories went into the live action.
It's been a while since I posted anything in here. I haven't done much that's terribly exciting, so I'm putting all of my new creations together.
First is a parcels van to match the old coaches.
Next is my take on a standard gauge D.Fusit wagon, built using GWR gunpowder wagon kits.
Lastly are some RWS style Troublesome Tankers. I chose the kit that I used because there were no braces on the tank ends.
My next project will be some slight alterations on the new autocoaches that I mention in the "New Acquisitions" thread. After that, I have some narrow gauge projects in the works.
I haven't been on in a while, but I swung by to check the 2019 announcements. I decided to post my models of BoCo and Bradford while I was here. I went ahead and made BoCo because I'm fairly confident that Bachmann will never make him. I was originally going to make a generic break van using Bradford's kit, but I decided to go ahead and make Bradford because I though he would work with my war well wagon personality wise.
The face could be better, but I'm pretty new at it. He still needs decals, but they were out of stock last I looked.
CGI faces are even harder to use as a guide because they're so smooth, they don't really have "landmarks." Also, working with the wire and drilling the holes to make the handrails on this kit was a nightmare.


displayed on one of the GPIO ports of HC12 micro-controller.
serve as a way to better understand it.
> displayed on one of the GPIO ports of HC12 micro-controller.
> serve as a way to better understand it.
new words and punctuation. Find a good book.
or even Amazon.com's used book section.
copies running around on the 'web.
what you asked for in C "looks" to the HC12 processor.
get that image loaded into your HC12.
of use to meet the things we do not like or do not expect.
>> displayed on one of the GPIO ports of HC12 micro-controller.
>> serve as a way to better understand it.
>new words and punctuation. Find a good book.
>or even Amazon.com's used book section.
>copies running around on the 'web.
>what you asked for in C "looks" to the HC12 processor.
>get that image loaded into your HC12.
Will this be enough to run on a simulator?


I get the error message "ProcessMonitor detected in your system, please restart and try again". What do I do?
I get a Cyclic Redundancy Error. What can I do?
Process Monitor is a free tool that monitors and displays in real-time all file system activity on a Microsoft Windows operating system.
As it is interfering with our client, if it has been running on your machine you need to restart your computer to be able to launch a GameSessions game.


text:
William Alwyn: the Suffolk composer who wasn't Britten
William Alwyn's First Symphony is coupled with Ralph Vaughan William's Job: A Masque for Dancing in the BBC Prom being given by Sakari Oramo and the BBC Symphony Orchestra tomorrow (Aug 13). Genuine thanks go to outgoing Prom director Roger Wright for putting together a programme that shows how classical music's big opportunity is neglected music. William Alwyn was the Suffolk composer who wasn't Britten, and suffered as a result. With Roger Wright moving to Snape hopefully this will be redressed, and perhaps we can look forward to a cycle of all five of Alwyn's magnificent symphonies spread across future Aldeburgh Festivals. Additional thanks go to Roger Wright for starting tomorrow's concert an hour early, thereby allowing me to catch the late train back to East Anglia. If any readers are at this Prom do say hello. It will be easy to spot me: I will be one of those in the audience not applauding between movements.
My ticket for the Alwyn/RVW Prom was bought at the box office. Any copyrighted material is included as "fair use", for the purpose of critical analysis only, and will be removed at the request of copyright owner(s).
aldeburgh festival bbc proms benjamin britten ralph vaughan williams roger wright sakari oramo william alwyn
Bookhound said…
Thanks for the Alwyn post. Yes, it would be wonderful to have a complete Alwyn symphonic cycle performed. Hope you enjoy tomorrow's concert.
Philip Amos said…
Your every reminder of neglected music is invaluable, Bob. Splendid. I think Alwyn may in particular need a boost, for I suspect that in the minds of many music lovers he is still too much associated with film scores, fine though those are.
I should very much like to hear Barbirolli's recordings of Alwyn. He commissioned the first two symphonies and recorded them in the early 50s. Remastered by Dutton, they are available on Archive Recordings (Limited Edition). Glorious John also recorded three tone poems, but I'm not sure when or if that recording is available. I suspect it is, but I haven't checked yet.
And lastly, something that really took me aback. If someone showed me the photo on the Chandos cover and asked me who it is, I would have said, "Oh, that's Isaiah Berlin". I should have been so certain of that, this morning I had to check no one had made a boner by googling images of Alwyn. That is he on the cover right enough, but he is Berlin's double. A trival thing, but so odd it's worth taking a look at photos of Berlin in his later years.
Philip, the previously unpublished recordings of Barbirolli conducting Lyra Angelica, The Magic Island, and Autumn Legend came out about a year ago, taken from the recordings that we hold here in the William Alwyn Archive at Cambridge University Library. It's a great recording too. http://www.barbirollisociety.co.uk/latest/barbirolli-conducts-william-alwyn
Book-hound, that is good news indeed! Thank you so much. Philip


text:
Q: Prime-aligned spiral A while ago, I came up with an algorithm that I called the arbitrary spiral. It lets me align whatever integers I'd like to lay on the positive $x$-axis in a spiral. This is what I got when I had it align prime numbers:

It's more symmetric than I thought.
Further out, more patterns appear (primes are in orange, all other integers are in black):

(image limit ≈ 1 million)
larger view  (limit ≈ 18 million)
even larger view (limit ≈70 million)
(An aligned spiral with random non-primes doesn't produce quite a symmetric image)
What I have already noticed is that numbers along the spokes at $\pm 60$ degrees (360 / (5 + 1) or $\frac{\pi}{3}$ rad) are not divisible by $5$. This appears to be true for numbers along $90$ (360/(3+1)) degrees, not divisible by $3$, as well as numbers along ±360/(7+1) = $45$ degrees not divisible by $7$ and so on. I have also learned of the interprimes along the negative x-axis.

The question is: What else can be observed in this image? Has anyone else done a spiral in this manner before?
Here's a Python script with the spiraling method:
# required modules: Pillow, primesieve (both can be installed via pip)
from PIL import Image, ImageDraw
import primesieve

from math import cos, sin, atan2, pi, degrees, sqrt
import random

size = (1500, 1500)  # image size
scale = .5 # image scaling
num = 80000000  # max value to iterate through

pnum = primesieve.count_primes(num)
arb_lst = primesieve.n_primes(pnum + 1)
arb_hgh, arb_low, arb_idx = 0, -1, 0
def arbi(n):
    '''Will spiral a number line such that
     an arbitrary set of given numbers
     are alined to the +x axis'''
    global arb_hgh, arb_low, arb_idx, arb_lst
    # while one can calculate n's position directly,
    # it's much faster to cycle through it in this manner

    while n > arb_hgh:  # cycle to next range
        arb_low = arb_hgh  # current high is now new low
        arb_hgh = arb_lst[arb_idx]  # move to next high position
        arb_idx += 1  # advance index for next time

    # calc. position for n on spiral
    c = (n - arb_low) / float(arb_hgh - arb_low)
    x = cos(c * 2 * pi) * sqrt(n)#n
    y = sin(c * 2 * pi) * sqrt(n)#n
    return x, -y  # image y coords are opposite of math coords

img = Image.new('RGB', size, (198, 176, 139))
drw = ImageDraw.Draw(img)

# colors (default is black)
p_col = (250, 150,  25)  # primes
s_col = ( 25, 150, 200)  # squares
c_col = (255, 255,  10)  # cubes

# lists to plot
ints = range(num)
squ = (i * i for i in ints)
cub = (i * i * i for i in ints)
prms = arb_lst[:-1]
query = []

arrangement = [(0, ints), #(s_col, squ), (c_col, cub),
               (p_col, prms)]

lim = sqrt(sum(i * i for i in size))  # image limit
for idx, (col, seq) in enumerate(arrangement, 1):
    arb_hgh, arb_low, arb_idx = 0, -1, 0  # reset spiral bounds

    tmp = col
    print('loop {}/{}'.format(idx, len(arrangement)))
    for i in seq:
        x, y = arbi(i)

        #if round(degrees(atan2(-y, x))) in (60,):# -7.5):
        #    col = (255, 0, 0); query.append(i)
        #else: col = tmp

        x *= scale; x += (size[0] / 2)
        y *= scale; y += (size[1] / 2)

        if sqrt(x * x + y * y) > lim:
            print('breakout at', i)
            break

        drw.point((x, y), fill=col)

img = img.convert("RGB")
#img.save('large.png')
img.show()

redpajama_set_name: RedPajamaStackExchange


Brentwood, be sure to browse our well-selected directory.
After graduating with BSc (Hons) in Biological Sciences in 1997 I have since worked in pharmaceutical manufacturing quality control/quality assurance. Following site closure in 2013, I started up my... own holistic therapy business, which I now run alongside a role back in pharma.
After completing an honours degree from King's College London, I joined the Civil Service. Following an accomplished and successful career spanning more than 13 years, I decided to change direction... and trained, firstly in acupuncture and subsequently in Chinese herbal medicine, at the London College of Traditional Acupuncture and Oriental Medicine (LCTA). I hold Licentiate Diplomas in acupuncture Lic. Ac.) (2002) and Oriental Herbal Medicine (Lic.
Deidre and Penelope formed Deepen Holistic following the completion of their training at Phoenix Holistic Training School. They both gained Level 3 Diploma in Reflexology, City and Guilds Certificate... (Distinction) in Indian Head Massage and Certificate in Hopi Ear Candling. Both Deidre and Penelope also run Baby and Toddler Reflex workshops for parents and carers. Penelope Morrison lives and works in Hutton, Brentwood, Essex and offers a mobile service in this and surrounding areas.


text:
Q: Setting SVG objects to specific locations Is there a way I could move an SVG object to a specific location in Python? I have an floor plan in vectorized format here and let's say for example I would like to place a toilet icon at (222, 382). I couldn't find any suitable libraries to achieve this so any recommendations would be appreciated. Using svgutils I managed to merge the two SVG files the following way
fplan = svgutils.transform.fromfile('floorplan.svg')
toilet = svgutils.transform.fromfile('toilet.svg')
fplan.append(toilet)
fplan.save('result.svg')

Here's the floor plan
<svg width="781" height="480"
xmlns="http://www.w3.org/2000/svg">
<path d="M313 181 351 181 351 187 313 187 " style="stroke:black" class="wall 2"/>
<path d="M393 166 468 166 468 170 393 170 " style="stroke:black" class="wall 2"/>
<path d="M219 324 221 324 221 337 219 337 " style="stroke:black" class="wall 2"/>
<path d="M356 341 392 341 392 343 356 343 " style="stroke:black" class="wall 2"/>
<path d="M356 243 389 243 389 245 356 245 " style="stroke:black" class="wall 2"/>
<path d="M737 44 741 44 741 219 737 219 " style="stroke:black" class="wall 8"/>
<path d="M618 213 741 213 741 219 618 219 " style="stroke:black" class="wall 8"/>
<path d="M382 343 392 343 392 422 382 422 " style="stroke:black" class="wall 2"/>
<path d="M289 412 392 412 392 422 289 422 " style="stroke:black" class="wall 2"/>
<path d="M618 213 630 213 630 347 618 347 " style="stroke:black" class="wall 2"/>
<path d="M382 337 630 337 630 347 382 347 " style="stroke:black" class="wall 2"/>
<path d="M36 318 50 318 50 411 36 411 " style="stroke:black" class="wall 2"/>
<path d="M36 411 135 411 135 423 36 423 " style="stroke:black" class="wall 2"/>
<path d="M37 32 319 32 319 48 37 48 " style="stroke:black" class="wall 2"/>
<path d="M37 32 49 32 49 180 37 180 " style="stroke:black" class="wall 2"/>
<path d="M618 36 741 36 741 44 618 44 " style="stroke:black" class="wall 2"/>
<path d="M289 246 295 246 295 308 289 308 " style="stroke:black" class="wall 2"/>
<path d="M217 242 295 242 295 246 217 246 " style="stroke:black" class="wall 2"/>
<path d="M385 245 389 245 389 337 385 337 " style="stroke:black" class="wall 2"/>
<path d="M618 48 630 48 630 213 618 213 " style="stroke:black" class="wall 2"/>
<path d="M313 32 630 32 630 48 313 48 " style="stroke:black" class="wall 2"/>
<path d="M217 181 273 181 273 187 217 187 " style="stroke:black" class="wall 2"/>
<path d="M217 188 223 188 223 242 217 242 " style="stroke:black" class="wall 2"/>
<path d="M37 180 223 180 223 188 37 188 " style="stroke:black" class="wall 2"/>
<path d="M313 48 319 48 319 181 313 181 " style="stroke:black" class="wall 2"/>
<path d="M127 320 223 320 223 324 127 324 " style="stroke:black" class="wall 2"/>
<path d="M127 326 135 326 135 412 127 412 " style="stroke:black" class="wall 2"/>
<path d="M36 318 135 318 135 326 36 326 " style="stroke:black" class="wall 2"/>
<path d="M289 308 295 308 295 412 289 412 " style="stroke:black" class="wall 2"/>
<path d="M217 306 295 306 295 308 217 308 " style="stroke:black" class="wall 2"/>
<path d="M217 306 223 306 223 324 217 324 " style="stroke:black" class="wall 2"/>
<path d="M273 181 319 181 319 187 273 187 " style="stroke:black" class="wall 2"/>
<path d="M127 412 283 412 283 422 127 422 " style="stroke:black" class="wall 2"/>
<path d="M283 413 295 413 295 421 283 421 " style="stroke:black" class="wall 2"/>
<path d="M217 242 223 242 223 306 217 306 " style="stroke:black" class="wall 2"/>
<path d="M37 180 49 180 49 318 37 318 " style="stroke:black" class="wall 2"/>
<path d="M320 151 349 151 349 179 320 179 " style="fill-opacity: 1; stroke-opacity: 1;" fill="#ffffff" stroke="#000000 " class="icon 4"/>
<path d="M321 121 349 121 349 151 321 151 " style="fill-opacity: 1; stroke-opacity: 1;" fill="#ffffff" stroke="#000000 " class="icon 4"/>
<path d="M189 243 217 243 217 266 189 266 " style="fill-opacity: 1; stroke-opacity: 1;" fill="#ffffff" stroke="#000000 " class="icon 3"/>
<path d="M356 268 383 268 383 292 356 292 " style="fill-opacity: 1; stroke-opacity: 1;" fill="#ffffff" stroke="#000000 " class="icon 3"/>
<path d="M276 152 316 152 316 180 276 180 " style="fill-opacity: 1; stroke-opacity: 1;" fill="#ffffff" stroke="#000000 " class="icon 3"/>
<path d="M356 292 382 292 382 339 356 339 " style="fill-opacity: 1; stroke-opacity: 1;" fill="#ffffff" stroke="#000000 " class="icon 3"/>
<path d="M189 266 217 266 217 289 189 289 " style="fill-opacity: 1; stroke-opacity: 1;" fill="#ffffff" stroke="#000000 " class="icon 3"/>
<path d="M189 290 217 290 217 318 189 318 " style="fill-opacity: 1; stroke-opacity: 1;" fill="#ffffff" stroke="#000000 " class="icon 3"/>
<path d="M56 328 78 328 78 343 56 343 " style="fill-opacity: 1; stroke-opacity: 1;" fill="#ffffff" stroke="#000000 " class="icon 4"/>
<path d="M418 135 442 135 442 164 418 164 " style="fill-opacity: 1; stroke-opacity: 1;" fill="#ffffff" stroke="#000000 " class="icon 4"/>
<path d="M355 245 383 245 383 268 355 268 " style="fill-opacity: 1; stroke-opacity: 1;" fill="#ffffff" stroke="#000000 " class="icon 3"/>
<path d="M249 392 274 392 274 412 249 412 " style="stroke:black" class="icon 6"/>
<path d="M223 257 253 257 253 273 223 273 " style="stroke:black" class="icon 5"/>
<path d="M273 49 309 49 309 79 273 79 " style="fill-opacity: 1; stroke-opacity: 1;" fill="#ffffff" stroke="#000000 " class="icon 3"/>
<path d="M260 309 287 309 287 336 260 336 " style="fill-opacity: 1; stroke-opacity: 1;" fill="#ffffff" stroke="#000000 " class="icon 4"/>
<path d="M222 382 239 382 239 411 222 411 " style="stroke:black" class="icon 5"/>
<path d="M411 50 438 50 438 79 411 79 " style="fill-opacity: 1; stroke-opacity: 1;" fill="#ffffff" stroke="#000000 " class="icon 4"/>
<path d="M223 310 251 310 251 336 223 336 " style="fill-opacity: 1; stroke-opacity: 1;" fill="#ffffff" stroke="#000000 " class="icon 3"/>
<path d="M381 52 410 52 410 78 381 78 " style="stroke:black" class="icon 6"/>
<path d="M253 284 278 284 278 303 253 303 " style="stroke:black" class="icon 6"/>
<path d="M56 379 125 379 125 408 56 408 " style="stroke:black" class="icon 7"/>
<path d="M323 412 365 412 365 422 323 422 " style="stroke:black" class="icon 2"/>
<path d="M618 220 630 220 630 316 618 316 " fill="#f0f0ff" stroke="#000000" style="fill-opacity: 1; stroke-width: 1; stroke-opacity: 1;" class="icon 1"/>
<path d="M36 367 50 367 50 396 36 396 " fill="#f0f0ff" stroke="#000000" style="fill-opacity: 1; stroke-width: 1; stroke-opacity: 1;" class="icon 1"/>
<path d="M37 67 49 67 49 151 37 151 " fill="#f0f0ff" stroke="#000000" style="fill-opacity: 1; stroke-width: 1; stroke-opacity: 1;" class="icon 1"/>
<path d="M289 251 295 251 295 288 289 288 " style="stroke:black" class="icon 2"/>
<path d="M618 164 630 164 630 203 618 203 " style="stroke:black" class="icon 2"/>
<path d="M618 58 630 58 630 160 618 160 " fill="#f0f0ff" stroke="#000000" style="fill-opacity: 1; stroke-width: 1; stroke-opacity: 1;" class="icon 1"/>
<path d="M227 181 264 181 264 187 227 187 " style="stroke:black" class="icon 2"/>
<path d="M217 191 223 191 223 228 217 228 " style="stroke:black" class="icon 2"/>
<path d="M127 329 135 329 135 367 127 367 " style="stroke:black" class="icon 2"/>
<path d="M289 342 295 342 295 379 289 379 " style="stroke:black" class="icon 2"/>
<path d="M37 196 49 196 49 282 37 282 " fill="#f0f0ff" stroke="#000000" style="fill-opacity: 1; stroke-width: 1; stroke-opacity: 1;" class="icon 1"/>

and here's the toilet icon
<svg version="1.1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" preserveAspectRatio="xMidYMid meet" viewBox="0 0 23.92 36.54" width="23.92" height="36.54">
    <defs>
        <path d="M1.99 36.54C3.99 36.54 19.93 36.54 21.93 36.54C23.03 36.54 23.92 35.65 23.92 34.55C23.92 33.95 23.92 29.17 23.92 28.57C23.92 27.47 23.03 26.58 21.93 26.58C19.93 26.58 3.99 26.58 1.99 26.58C0.89 26.58 0 27.47 0 28.57C0 29.76 0 33.35 0 34.55C0 35.65 0.89 36.54 1.99 36.54Z" id="a2eDjbk0uV"></path>
        <path d="M1.99 36.54C3.99 36.54 19.93 36.54 21.93 36.54C23.03 36.54 23.92 35.65 23.92 34.55C23.92 33.95 23.92 29.17 23.92 28.57C23.92 27.47 23.03 26.58 21.93 26.58C19.93 26.58 3.99 26.58 1.99 26.58C0.89 26.58 0 27.47 0 28.57C0 29.76 0 33.35 0 34.55C0 35.65 0.89 36.54 1.99 36.54Z" id="e5wOq9mEa8"></path>
        <path d="M11.96 0C20.6 0 27.24 12.79 20.6 26.58C17.14 26.58 6.78 26.58 3.32 26.58C-3.32 12.79 3.32 0 11.96 0Z" id="a9PrqQ5EK"></path>
        <path d="M11.96 0C20.6 0 27.24 12.79 20.6 26.58C17.14 26.58 6.78 26.58 3.32 26.58C-3.32 12.79 3.32 0 11.96 0Z" id="bZhtURMbo"></path>
        <path d="M1.99 36.54C3.99 36.54 19.93 36.54 21.93 36.54C23.03 36.54 23.92 35.65 23.92 34.55C23.92 33.95 23.92 29.17 23.92 28.57C23.92 27.47 23.03 26.58 21.93 26.58C19.93 26.58 3.99 26.58 1.99 26.58C0.89 26.58 0 27.47 0 28.57C0 29.76 0 33.35 0 34.55C0 35.65 0.89 36.54 1.99 36.54Z" id="b11tFtOzmt"></path>
        <path d="M1.99 36.54C3.99 36.54 19.93 36.54 21.93 36.54C23.03 36.54 23.92 35.65 23.92 34.55C23.92 33.95 23.92 29.17 23.92 28.57C23.92 27.47 23.03 26.58 21.93 26.58C19.93 26.58 3.99 26.58 1.99 26.58C0.89 26.58 0 27.47 0 28.57C0 29.76 0 33.35 0 34.55C0 35.65 0.89 36.54 1.99 36.54Z" id="c1PUKRgLfD"></path>
        <path d="M11.96 32.89C11.23 32.89 10.63 32.29 10.63 31.56C10.63 30.82 11.23 30.23 11.96 30.23C12.69 30.23 13.29 30.82 13.29 31.56C13.29 32.29 12.69 32.89 11.96 32.89Z" id="g10I3hqSN1"></path>
        <path d="M11.96 32.89C11.23 32.89 10.63 32.29 10.63 31.56C10.63 30.82 11.23 30.23 11.96 30.23C12.69 30.23 13.29 30.82 13.29 31.56C13.29 32.29 12.69 32.89 11.96 32.89Z" id="d89XHCQTO"></path>
        <path d="M3.32 26.58C-3.32 12.79 3.32 0 11.96 0C20.6 0 27.24 12.79 20.6 26.58" id="a8H8jQsC7x"></path>
        <path d="M3.32 26.58C-3.32 12.79 3.32 0 11.96 0C20.6 0 27.24 12.79 20.6 26.58" id="f1cQ6pYoi"></path>
    </defs>
    <g>
        <g>
            <g>
                <use xlink:href="#a2eDjbk0uV" opacity="1" fill="#ffffff" fill-opacity="1"></use>
                <g>
                    <use xlink:href="#a2eDjbk0uV" opacity="1" fill-opacity="0" stroke="#000000" stroke-width="1" stroke-opacity="0"></use>
                </g>
            </g>
            <g>
                <use xlink:href="#e5wOq9mEa8" opacity="1" fill="#000000" fill-opacity="0"></use>
                <g>
                    <use xlink:href="#e5wOq9mEa8" opacity="1" fill-opacity="0" stroke="#ffffff" stroke-width="0.6" stroke-opacity="1"></use>
                </g>
            </g>
            <g>
                <use xlink:href="#a9PrqQ5EK" opacity="1" fill="#ffffff" fill-opacity="1"></use>
                <g>
                    <use xlink:href="#a9PrqQ5EK" opacity="1" fill-opacity="0" stroke="#000000" stroke-width="1" stroke-opacity="0"></use>
                </g>
            </g>
            <g>
                <use xlink:href="#bZhtURMbo" opacity="1" fill="#000000" fill-opacity="0"></use>
                <g>
                    <use xlink:href="#bZhtURMbo" opacity="1" fill-opacity="0" stroke="#ffffff" stroke-width="0.6" stroke-opacity="1"></use>
                </g>
            </g>
            <g>
                <use xlink:href="#b11tFtOzmt" opacity="1" fill="#000000" fill-opacity="0"></use>
                <g>
                    <use xlink:href="#b11tFtOzmt" opacity="1" fill-opacity="0" stroke="#000000" stroke-width="1" stroke-opacity="0"></use>
                </g>
            </g>
            <g>
                <use xlink:href="#c1PUKRgLfD" opacity="1" fill="#000000" fill-opacity="0"></use>
                <g>
                    <use xlink:href="#c1PUKRgLfD" opacity="1" fill-opacity="0" stroke="#000000" stroke-width="0.6" stroke-opacity="1"></use>
                </g>
            </g>
            <g>
                <use xlink:href="#g10I3hqSN1" opacity="1" fill="#000000" fill-opacity="0"></use>
                <g>
                    <use xlink:href="#g10I3hqSN1" opacity="1" fill-opacity="0" stroke="#000000" stroke-width="1" stroke-opacity="0"></use>
                </g>
            </g>
            <g>
                <use xlink:href="#d89XHCQTO" opacity="1" fill="#000000" fill-opacity="0"></use>
                <g>
                    <use xlink:href="#d89XHCQTO" opacity="1" fill-opacity="0" stroke="#000000" stroke-width="0.6" stroke-opacity="1"></use>
                </g>
            </g>
            <g>
                <use xlink:href="#a8H8jQsC7x" opacity="1" fill="#000000" fill-opacity="0"></use>
                <g>
                    <use xlink:href="#a8H8jQsC7x" opacity="1" fill-opacity="0" stroke="#000000" stroke-width="1" stroke-opacity="0"></use>
                </g>
            </g>
            <g>
                <use xlink:href="#f1cQ6pYoi" opacity="1" fill="#000000" fill-opacity="0"></use>
                <g>
                    <use xlink:href="#f1cQ6pYoi" opacity="1" fill-opacity="0" stroke="#000000" stroke-width="0.6" stroke-opacity="1"></use>
                </g>
            </g>
        </g>
    </g>
</svg>

A: The toilet icon is too verbous. You can delete all you have after the defs and transform the defs in a symbol with a viewBox attribute. I'm using viewBox="-1 -1 26 38" a little different of what you have since part of the stroke was falling outside the viewBox.
Now you can reuse the symbol with <use> as many times you need. The use element can take a x and y attributes to be placed where you need. Also since the symbol have a viewBox the use can take a width and a height if you need a different size of the icon.
If you don't need to change the size don't use a a width and a height for the use element

<svg viewBox="0 0781 480" width="781" height="480">
<symbol id="toilet" viewBox="-1 -1 26 38">
        <path d="M1.99 36.54C3.99 36.54 19.93 36.54 21.93 36.54C23.03 36.54 23.92 35.65 23.92 34.55C23.92 33.95 23.92 29.17 23.92 28.57C23.92 27.47 23.03 26.58 21.93 26.58C19.93 26.58 3.99 26.58 1.99 26.58C0.89 26.58 0 27.47 0 28.57C0 29.76 0 33.35 0 34.55C0 35.65 0.89 36.54 1.99 36.54Z" id="a2eDjbk0uV"></path>
        <path d="M1.99 36.54C3.99 36.54 19.93 36.54 21.93 36.54C23.03 36.54 23.92 35.65 23.92 34.55C23.92 33.95 23.92 29.17 23.92 28.57C23.92 27.47 23.03 26.58 21.93 26.58C19.93 26.58 3.99 26.58 1.99 26.58C0.89 26.58 0 27.47 0 28.57C0 29.76 0 33.35 0 34.55C0 35.65 0.89 36.54 1.99 36.54Z" id="e5wOq9mEa8"></path>
        <path d="M11.96 0C20.6 0 27.24 12.79 20.6 26.58C17.14 26.58 6.78 26.58 3.32 26.58C-3.32 12.79 3.32 0 11.96 0Z" id="a9PrqQ5EK"></path>
        <path d="M11.96 0C20.6 0 27.24 12.79 20.6 26.58C17.14 26.58 6.78 26.58 3.32 26.58C-3.32 12.79 3.32 0 11.96 0Z" id="bZhtURMbo"></path>
        <path d="M1.99 36.54C3.99 36.54 19.93 36.54 21.93 36.54C23.03 36.54 23.92 35.65 23.92 34.55C23.92 33.95 23.92 29.17 23.92 28.57C23.92 27.47 23.03 26.58 21.93 26.58C19.93 26.58 3.99 26.58 1.99 26.58C0.89 26.58 0 27.47 0 28.57C0 29.76 0 33.35 0 34.55C0 35.65 0.89 36.54 1.99 36.54Z" id="b11tFtOzmt"></path>
        <path d="M1.99 36.54C3.99 36.54 19.93 36.54 21.93 36.54C23.03 36.54 23.92 35.65 23.92 34.55C23.92 33.95 23.92 29.17 23.92 28.57C23.92 27.47 23.03 26.58 21.93 26.58C19.93 26.58 3.99 26.58 1.99 26.58C0.89 26.58 0 27.47 0 28.57C0 29.76 0 33.35 0 34.55C0 35.65 0.89 36.54 1.99 36.54Z" id="c1PUKRgLfD"></path>
        <path d="M11.96 32.89C11.23 32.89 10.63 32.29 10.63 31.56C10.63 30.82 11.23 30.23 11.96 30.23C12.69 30.23 13.29 30.82 13.29 31.56C13.29 32.29 12.69 32.89 11.96 32.89Z" id="g10I3hqSN1"></path>
        <path d="M11.96 32.89C11.23 32.89 10.63 32.29 10.63 31.56C10.63 30.82 11.23 30.23 11.96 30.23C12.69 30.23 13.29 30.82 13.29 31.56C13.29 32.29 12.69 32.89 11.96 32.89Z" id="d89XHCQTO"></path>
        <path d="M3.32 26.58C-3.32 12.79 3.32 0 11.96 0C20.6 0 27.24 12.79 20.6 26.58" id="a8H8jQsC7x"></path>
        <path d="M3.32 26.58C-3.32 12.79 3.32 0 11.96 0C20.6 0 27.24 12.79 20.6 26.58" id="f1cQ6pYoi"></path>

</symbol>

<use xlink:href="#toilet" x="222" y="382" width="52" height="76"  fill="none" stroke="black"  />
</svg>


text:
Zanwar S
Joshi A
Noronha V
Patil V
Sable N
Popat P
Menon S
Kothari R
Bhargava P
Kapoor A
Prabhash K
Indian Kidney Cancer Registry
metastatic renal cell carcinoma
second-line targeted therapy renal cell carcinoma
» Methods
Patterns of care and outcomes for second-line targeted therapy in metastatic renal cell carcinomas: A registry based analysis
S Zanwar1, A Joshi2, V Noronha2, VM Patil2, N Sable3, P Popat3, S Menon4, R Kothari2, P Bhargava2, A Kapoor2, K Prabhash2
1 Department of Medical Oncology, Tata Memorial Centre, Mumbai, Maharashtra, India
2 Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India
3 Department of Radiology, Tata Memorial Hospital, Mumbai, Maharashtra, India
4 Department of Pathology, Tata Memorial Hospital, Mumbai, Maharashtra, India
K Prabhash
Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra
DOI: 10.4103/ijc.IJC_25_17
AIM: Patterns of care for metastatic renal cell carcinomas (mRCC) have seen tremendous reform in the last decade. Here, we present our pattern of care in second-line targeted therapy for mRCC. METHODS: Patients with mRCC treated with second-line therapy were included from a prospective database. Demographics, risk stratification, and treatment details were noted. Event-free survival (EFS) and overall survival (OS) was calculated using Kaplan–Meier method. Log-rank test was used to identify factors affecting EFS and OS. Multivariate analysis was performed using cox regression. RESULTS: Nearly 21.7% (46/212) of patients received second-line targeted treatment. Heng score for risk stratification showed 21.7% of patients in low risk, 36.9% in intermediate, and 34.8% in high risk group. Everolimus followed by pazopanib were the most common second-line therapies used in 65.2% and 13% of patients, respectively. The estimated median EFS was 3.5 months (95% confidence interval [CI] 2.7–4.26 months) and estimated median OS from the start of second-line therapy was 6.2 months (95% CI 3.4–9.0 months) with a median follow-up of 4.3 months. On univariate log-rank analysis, EFS of more than 6 months with first-line therapy was associated with improvement in EFS with second-line therapy (9.5 vs. 2.0 months; hazard ratio (HR) 0.364; P = 0.002). There was no factor independently associated with EFS or OS on multivariate analysis. CONCLUSION: Patterns of care for second line targeted therapy tend to vary with setting. A longer EFS with first-line therapy predicts improved outcomes with second-line treatment.
Keywords: Indian Kidney Cancer Registry, metastatic renal cell carcinoma, second-line targeted therapy renal cell carcinoma
Zanwar S, Joshi A, Noronha V, Patil V, Sable N, Popat P, Menon S, Kothari R, Bhargava P, Kapoor A, Prabhash K. Patterns of care and outcomes for second-line targeted therapy in metastatic renal cell carcinomas: A registry based analysis. Indian J Cancer 2016;53:579-82
Zanwar S, Joshi A, Noronha V, Patil V, Sable N, Popat P, Menon S, Kothari R, Bhargava P, Kapoor A, Prabhash K. Patterns of care and outcomes for second-line targeted therapy in metastatic renal cell carcinomas: A registry based analysis. Indian J Cancer [serial online] 2016 [cited 2020 Jan 23];53:579-82. Available from: http://www.indianjcancer.com/text.asp?2016/53/4/579/204757
Treatment of metastatic renal cell carcinoma (mRCC) has seen a tremendous reform in the past decade.[1] The impressive results of targeted therapy have not been restricted to the first line setting with multiple agents being added to the therapeutic armamentarium for second-line therapy and beyond.[2],[3],[4],[5],[6] Till recently, there were only two drugs approved by the United States Food and Drug Administration for use in the second-line setting. This has changed dramatically in the last 2–3 years.[7] The patient population seen in the clinic is often underrepresented in clinical trial setting undermining the applicability of their results in day-to-day clinical practice.[8] Because of various reasons drug used in routine clinical practice may vary from the approved label. Herein lies the importance to evaluate the pattern of treatment and evaluate outcomes of patients treated in the clinic. In this study, we present the results of pattern of use of drugs and also outcome of mRCC patients treated with second-line treatment in palliative setting.
Patients were included in this study from a prospective database maintained in the medical oncology department. All patients with histologically proven and receiving second-line therapy in palliative setting for RCC between January 2012 and August 2016 were selected for this study. Patients either had radiologic progression post first-line therapy or required stopping first-line therapy due to unacceptable toxicity. Tumors with all histologies were included in the study population. Patients' date of diagnosis, date of diagnosis for metastatic disease, demographic details, date of progression, date of change of treatment, and date of death were also collected. Data for risk stratification were also collected including performance status, time from diagnosis to systemic treatment, serum calcium and lactate dehydrogenase, hemoglobin, baseline platelets, and neutrophils.
Details of the systemic therapy including drug, dose schedule, dose modification, dose interruption were collected. Therapy administered in first line was also collected.
Response assessment was performed using computed tomography scans of the thorax, abdomen and pelvis with contrast enhancement unless contraindication due to deranged renal functions. Response scans were performed every 3–4 months or earlier in case of clinical suspicion of progression. Response was assessed using RECIST version 1.1 criteria.[9] Definitions of complete response (CR), partial response (PR), stable disease, and progressive disease were as per RECIST 1.1 criteria.[9] Objective response rate (ORR) was defined as CR plus PR. Radiologic response was assessed by experienced radiologists in the uro-oncology disease management group.
Demographic data are described in percentages. Event free survival (EFS) was calculated from start of second line therapy till progression, death, stoppage of therapy due to unacceptable toxicity or loss to follow up. Overall survival (OS) was calculated from the start of second line therapy till death or loss to follow-up. EFS and OS were estimated using Kaplan–Meier method. Data were censored for analysis with the last date as August 30, 2016. Univariate Log-rank test was applied for identifying factors affecting EFS and OS. Eastern Cooperative Oncology Group (ECOG) Performance status at the start of second-line therapy, Heng score at diagnosis with mRCC, EFS with first-line therapy and type of second-line therapy used (mTOR vs. multikinase inhibitors [MKI]) were analyzed using multivariate logistic regression for factors affecting EFS and OS. Statistical analysis was performed using SPSS version 20.0 software (IBM SPSS Statistics for Windows, Version 20.0, IBM Corporation, Armonk, NY, USA).
This study was approved by the Institutional Review Board attached to Tata Memorial Hospital, Mumbai (Kidney Cancer Registry; project number 79). Informed consent of all participants was obtained before enrollment on the study. The study was registered with Clinical Trials Registry of India (approval number CTRI/2012/11/003147).
From January 2012 to August 2016, out of the 212 patients treated with first-line therapy, a total of 46 patients (21.7%) received second line targeted treatment. Sorafenib followed by sunitinib were the most common first line therapies used in 41.3% and 32.6% of patients, respectively. The median age of the cohort was 57 years (22–76 years). Majority of the patients (69.6%) had clear cell histology. Heng score for risk stratification showed patients to be predominantly in intermediate (36.9%) or high risk (34.8%) group with 21.7% of patients belonging to low risk group at presentation. Risk stratification data were incomplete in three patients. Performance status was 2 or less on the ECOG scale in 93.5% of the patients. Majority of the patients had undergone a curative intent nephrectomy (58.7%), either partial or radical, prior to presentation with metastatic disease and three patients had undergone cytoreductive nephrectomy on the diagnosis of metastatic disease. The demographic and baseline characteristics are shown in [Table 1].
Table 1: Baseline Characteristics
Response assessment showed an ORR of 2.2% (95% confidence interval [CI] 0.3–11.3%). One patient had partial response and no patients had a CR. Stable disease was noted in more than one-third (36.9%) of the patients, whereas 21 patients (45.7%) had progressive disease at first response evaluation. Response evaluation data were not available for 7 (15.2%) patents. Everolimus (65.4%) followed by pazopanib (13%) were the most commonly used drugs in second line. Drugs used in second-line therapy are shown in [Table 2]. Four patients (8.7%) required stopping of therapy due to unacceptable toxicity; one patients had grade III mucositis with everolimus which recurred despite dose reduction, one had grade III proteinuria with sunitinib despite dose reduction and drug free interval, one patient developed cardiac decompensation with congestive heart failure on sorafenib and another patient treated with axitinib had grade III hyperbilirubinemia.
Table 2: Drugs used in second line RCC
The estimated median EFS of the cohort was 3.5 months (95% CI 2.7–4.26 months) and estimated median OS from start of second line therapy was 6.2 months (95% CI 3.4–9.0 months) by Kaplan–Meier method with a median follow-up of 4.3 months. On univariate log-rank analysis, EFS of more than 6 months with first line therapy was the only factor associated with improvement in EFS with second line therapy (median EFS - 9.5 vs. 2.0 months; HR 0.364; P = 0.002) [Figure 1]. Among factors affecting OS, second line therapy with MKIs over mTOR inhibitors (P = 0.058) and EFS >6 months with first line therapy (P = 0.055) showed trend toward improvement in OS. The median survival in low risk group as per Heng criteria was 16 months as compared to median of 3.5 months in intermediate risk and 2.0 months in high risk patients. This difference however did not reach statistical significance (P = 0.08). The Memorial Sloan Kettering Cancer Centre criteria for risk stratification did not have an impact on EFS or OS for second line therapy. On multivariate analysis using Cox regression incorporating ECOG performance status, Heng score, EFS with first line therapy and type of second-line therapy (MKIs vs. mTOR inhibitors), there was no factor independently affecting EFS or OS.
Figure 1: Second line EFS comparison for patients with event free survival of >6 months versus ≤6 months with first-line therapy
Improvements in outcomes with first line treatment strategies means that more and more patients are being subjected to second line therapies and beyond. Indeed, as many as ten treatment options are recommended in the second line setting by the current National Comprehensive Cancer Network guidelines in patients pretreated with anti-angiogenic agents.[7] Many studies have shown improvement in progression free survival and now also in OS with nivolumab and cabozantinib.[4],[10],[11],[12],[13] Indeed, exposure to second line therapy has also been found to be independently associated with improvement OS in a recent report from clinical practice setting.[14]
Our study looked at the pattern of use of systemic therapy and outcomes of mRCC treated with second line targeted therapy. We were able to administer second-line therapy in approximately one-fifth of our patients who had received first line treatment. This figure is similar to that reported by the RECCORD registry where 15% of patients receiving second line therapy.[14] With the nonavailability of nivolumab or cabozantinib in the country and axitinib not being available for a fair duration of the study, majority of the second line therapy decisions were taken keeping in mind the cost and logistic constraints. MKIs used included sunitinib, sorafenib, pazopanib and axitinib and mTOR inhibitors used included everolimus. The treatment plan took into consideration the prior therapy, comorbidities and resource constraints of the patients. Nevertheless, all the patients received one of the many accepted standard second line treatment options. Everolimus was the most commonly used drug in second line. This is in line with majority of the registry data.[14],[15],[16] The median age, male predominance and clear cell histology predominance seen in our study were similar to previous reports.[8],[14] Risk stratification was done using the criteria elaborated by Heng et al.[17] Majority of our study population belonged to high or intermediate risk group as per Heng criteria. This is in contrast to majority of clinical trial data where high risk patients have traditionally been underrepresented and is in cohesion with other reports from nontrial clinical practice setting.[8],[18]
The ORR of 2.2% is somewhat similar to previous reports from everolimus data.[4],[11]
The median EFS in our study is similar to previous reports of progression free survival with second line therapy.[4],[11],[12] However, the OS from start of second-line therapy appears to be lower than as compared to the OS reported from start of second-line therapy by the IMDC database review.[18] One of the factors that could have led to lower OS could be a higher proportion of patients in high risk group. The nonavailability of nivolumab or cabozantinib would not seem to have affected this survival as the historical data for comparison is from the prenivolumab era. The low number of cytoreductive nephrectomies performed in our study population is likely a reflection of the fact that majority underwent nephrectomy as radical treatment before relapse.
Among factors affecting EFS with second line therapy, an EFS of more than 6 months with first-line therapy was significantly associated with improved survival. This might be an explained by selection of a good biology disease that continues to respond well to second line therapy as well. On multivariate analysis, there was however no factor individually affecting EFS. Among factors affecting OS, Heng criteria based risk stratification suggested a trend toward its utility as a prognostic tool in this setting. Indeed, these criteria have been validated in the targeted therapy era and have shown to predict prognostic even for outcomes with second line therapy.[19] Another factor which showed trend toward survival benefit on univariate analysis was the use of MKI such as sunitinib, pazopanib and sorafenib in second line over the mTOR inhibitors, everolimus and temsirolimus. This might be explained by the results of a randomized phase III study where sorafenib was found to be superior to temsirolimus in patients treated previously with sunitinib.[20] Majority of our patients had received MKI in the form of either sunitinib, sorafenib or pazopanib in first-line setting providing a similar clinical context as that evaluated in this study.[20] There was no factor independently associated with OS on multivariate analysis.
Toxicity analysis was excluded from the purview of this study as majority patients took the advised treatment at their primary care centers coming primarily for three monthly follow ups and response evaluation to us. The documentation of toxicities, especially grade I/II adverse events was at the best patchy. In our study, 8.7% of patients had to discontinue treatment due to unacceptable toxicity even in the face of a stable disease on treatment. This figure is similar to previous reports with various agents in second line setting.[11],[19]
This study is an earnest attempt to look into the outcomes of second line treatment in mRCC in a resource limited setting as ours. The small numbers and retrospective nature represent the most important constraints in interpretation of the findings of this study. Nevertheless, it does add assurity to the feasibility of this intervention with comparable PFS and toxicity related drug discontinuations as compared to existing clinical trial literature. It also gives an overview of the current practices and feasibility of these interventions in the "real world" setting given the disparity in the patient population enrolled in clinical trials. It would be interesting to have more data on toxicity and quality of life with different agents to better guide our treatment strategies in future.
Escudier B, Albiges L, Sonpavde G. Optimal management of metastatic renal cell carcinoma: Current status. Drugs 2013;73:427-38.
Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Rixe O, et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 2007;356:115-24.
Escudier B, Eisen T, Stadler WM, Szczylik C, Oudard S, Siebels M, et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 2007;356:125-34.
Motzer RJ, Escudier B, Oudard S, Hutson TE, Porta C, Bracarda S, et al. Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebo-controlled phase III trial. Lancet 2008;372:449-56.
Escudier B, Bellmunt J, Négrier S, Bajetta E, Melichar B, Bracarda S, et al. Phase III trial of bevacizumab plus interferon alfa-2a in patients with metastatic renal cell carcinoma (AVOREN): Final analysis of overall survival. J Clin Oncol 2010;28:2144-50.
Sternberg CN, Davis ID, Mardiak J, Szczylik C, Lee E, Wagstaff J, et al. Pazopanib in locally advanced or metastatic renal cell carcinoma: Results of a randomized phase III trial. J Clin Oncol 2010;28:1061-8.
National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology. Kidney Cancer V.3.2016; 2016. Available from: http://www.nccn.org/professionals/physician_gls/pdf/kidney.pdf. [Last accessed on 2016 Jan 09; 3:31:33 PM.]
Heng DY, Choueiri TK, Rini BI, Lee J, Yuasa T, Pal SK, et al. Outcomes of patients with metastatic renal cell carcinoma that do not meet eligibility criteria for clinical trials. Ann Oncol 2014;25:149-54.
Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, et al. New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1). Eur J Cancer 2009;45:228-47.
Motzer RJ, Escudier B, Tomczak P, Hutson TE, Michaelson MD, Negrier S, et al. Axitinib versus sorafenib as second-line treatment for advanced renal cell carcinoma: Overall survival analysis and updated results from a randomised phase 3 trial. Lancet Oncol 2013;14:552-62.
Motzer RJ, Escudier B, McDermott DF, George S, Hammers HJ, Srinivas S, et al. Nivolumab versus everolimus in advanced renal-cell carcinoma. N Engl J Med 2015;373:1803-13.
Choueiri TK, Escudier B, Powles T, Mainwaring PN, Rini BI, Donskov F, et al. Cabozantinib versus everolimus in advanced renal-cell carcinoma. N Engl J Med 2015;373:1814-23.
Choueiri TK, Escudier B, Powles T, Tannir NM, Mainwaring PN, Rini BI, et al. Cabozantinib versus everolimus in advanced renal cell carcinoma (METEOR): Final results from a randomised, open-label, phase 3 trial. Lancet Oncol 2016;17:917-27.
Wagstaff J, Jones R, Hawkins R, Porfiri E, Pickering L, Bahl A, et al. Treatment patterns and clinical outcomes in patients with renal cell carcinoma in the UK: Insights from the RECCORD registry. Ann Oncol 2016;27:159-65.
Jonasch E, Signorovitch JE, Lin PL, Liu Z, Culver K, Pal SK, et al. Treatment patterns in metastatic renal cell carcinoma: A retrospective review of medical records from US community oncology practices. Curr Med Res Opin 2014;30:2041-50.
De Groot S, Sleijfer S, Redekop WK, Oosterwijk E, Haanen JB, Kiemeney LA, et al. Variation in use of targeted therapies for metastatic renal cell carcinoma: Results from a Dutch population-based registry. BMC Cancer 2016;16:364.
Heng DY, Xie W, Regan MM, Warren MA, Golshayan AR, Sahi C, et al. Prognostic factors for overall survival in patients with metastatic renal cell carcinoma treated with vascular endothelial growth factor-targeted agents: Results from a large, multicenter study. J Clin Oncol 2009;27:5794-9.
Ko JJ, Xie W, Kroeger N, Lee JL, Rini BI, Knox JJ, et al. The International Metastatic Renal Cell Carcinoma Database Consortium model as a prognostic tool in patients with metastatic renal cell carcinoma previously treated with first-line targeted therapy: A population-based study. Lancet Oncol 2015;16:293-300.
Rini BI, Escudier B, Tomczak P, Kaprin A, Szczylik C, Hutson TE, et al. Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): A randomised phase 3 trial. Lancet 2011;378:1931-9.
Hutson TE, Escudier B, Esteban E, Bjarnason GA, Lim HY, Pittman KB, et al. Randomized phase III trial of temsirolimus versus sorafenib as second-line therapy after sunitinib in patients with metastatic renal cell carcinoma. J Clin Oncol 2014;32:760-7.
1 Biomarkers defining probability of receiving second-line targeted therapy in metastatic renal cell carcinoma
Pawel Chrom,Maciej Kawecki,Rafal Stec,Lubomir Bodnar,Cezary Szczylik,Anna M. Czarnecka
Medical Oncology. 2018; 35(6)


Experience a memorable Easter Sunday for our Easter Egg Gathering and Brunch.
Enjoy an evening out tasting specialty wines that are paired with local, flavourful food.
We've had a great five years of operations and we couldn't have done it without the community's support.
Crush your fitness goals during our early morning signature hiking program.
A musical duo that will surprise and delight you – their use of looping technology makes for a show that you have to hear to believe.
The Wells is a cover band from Squamish playing classic and modern rock songs from the '60s to today.
From the costumes to the music, Dreams is an authentic tribute band to Fleetwood Mac.
Enjoy mountainside yoga with ocean views. Yoga takes place from Monday to Friday.
Offering a repertoire of 2000+ songs from the best eras and genres of modern music, they produce a sound that is truly their own.
Hailing from Vancouver Island the Eagle Eyes' are a tribute band to the legendary music of the Eagles. Enjoy a selection of hits ranging from classic to country rock.
A one-of-a-kind backyard dining series for guests to enjoy a seafood boil designed menu all while sharing the experience with friends in a long table format.
Sean Kozak is a DJ, purveyor of fine grooves, he likes to dance, get others to do the same and really loves to watch sunsets.
The Whiskeydicks use fiery celtic-gypsy fiddle licks and voice to play songs people know but in a way they'd never imagine.
Their music is raw and exciting – full of fat bass lines, explosive drumming, guitar solos and impassioned vocals.
Performing timeless blues, R&B and rock classics, the band seeks to honour what the original artist brought to their music.
With grace and passion, Jocelyn is a vibrant fiddler that has performed all over the world with her spirited Celtic music and dance.
Ruckus Deluxe features former Cirque du Soleil lead singer Chad Oliver and Grammy-nominated violinist Ian Cameron.
Offering a raw and unique style, Dakota Pearl is one of British Columbia's up and coming Outlaw/Alt Country rock bands.
Celebrate the end of summer, birthdays & other special moments at our end of summer wine dinner paired with the sounds of the elegant Kirsten Price Jazz Trio.
Cam Salay is a Juno award winner as a member of The Paperboys and continues to work as a solo performer as well as a duo.
The Sea to Sky Gondola welcomes costume-clad trick-or-treaters of all ages for an afternoon of seasonal surprises, face-painting and Trick or Treating.
Children of all ages are invited to visit the Summit for a pancake breakfast followed by an opportunity to take photos with Santa.
Get into the holiday spirit and enjoy a festive menu with your colleagues in the beautifully decorated Summit Lodge.
Experience our holiday wine dinner at the Summit. Treat your tastebuds to a wonderful combination of local food and wine.
Discover pristine solitude, excitement and enjoy the outdoors this winter on a guided snowshoe.


text:
Subj: Re: Walking Dead Season 7 pic and screen date for Season 7 trailer
Posted: Sun Jul 17, 2016 at 08:54:10 am CDT (Viewed 459 times)
Reply Subj: Walking Dead Season 7 pic and screen date for Season 7 trailer
Posted: Thu Jul 14, 2016 at 12:39:49 pm CDT (Viewed 521 times)
So omitting Carl and Rick and the women, that leaves:
1. Glenn
2. Daryl
4. Aaron (the one that recruited Rick's crew to Alexandria)
5. Eugene
So of the five, who is perhaps the most useless character that they could live without?
Well for me that sounds like EUGENE. In recent episodes he had begun to man up and start to fight and that is great, but still he is easily captured as shown twice after he started to man up and be a fighter. He also passed the bullet making formula to Rick in case something happened to him. That to me feels like a hint that Eugene is going to die.
Eugene's far more useful than Aaron. IMO, the only reason he even volunteered for the mission is to perhaps be more fodder. And he's not the gay character of the show. There are several gay characters.
However, I don't think it's him, and I don't think they're going to kill the "most useless." They going to go with the opposite. And I doubt there will be just one death.
City of Heroes is BACK!
Walking Dead Season 7 pic and screen date for Season 7 trailer · Iron Man Unit 007 · Thu Jul 14, 2016 at 12:39:49 pm CDT
Re: Walking Dead Season 7 pic and screen date for Season 7 trailer · Reverend Meteor · Sun Jul 17, 2016 at 08:01:27 pm CDT
Re: Walking Dead Season 7 pic and screen date for Season 7 trailer · The Black Guardian · Sun Jul 17, 2016 at 08:54:10 am CDT
Agreed, There is a pretty clear consensus that he kills · Bk Ray · Wed Aug 03, 2016 at 12:57:10 pm CDT


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text:
'In the meantime I died…'
May 8, 2019 February 14, 2021 Floris Steenvoorden
If we translate the poster in the pictures of Foundation ALS from Dutch to English it says: 'Ik ben inmiddels overleden' which means 'In the meantime I died'. Yes, you're reading it correct: the people in the picture sadly lost their fight against ALS and they passed away.
Foundation ALS in The Netherlands photographed 9 patients with ALS in 2012. If one of the photographed patients would die, his or her picture would be used for an advertisement campaign. The last patient died in 2017, this is also when the campaign ended. The goal of this campaign is to stimulate people to donate for research of ALS, a progressive neurodegenerative disorder. ALS attacks certain cells in the brain and spinal cord needed to keep our muscles moving. Most people with ALS live on average 2-5 years after their first signs of disease.
As a Dutch resident, this campaign was seen everywhere: bus stations, newspapers, television and more. It doesn't make you comfortable to see a 'normal' person pictured who sadly already passed away. However, awareness of ALS is so important. The campaign was a success: the name awareness increased from 20% to 90% (!!). The willingness to donate increased with 45%.
What do you think about this campaign? Would a campaign like this be a success in the United States? Does it go to far for you?
#netherlands #publicart #advertising #health
Floris Steenvoorden
Victim Fashion: Goes heated ProRail Campaign too far?
Fashion's Obsession with Domestic Abuse The "Bad Guy" Critique The Out-of-Season Burn Selling Sex Instead of Clothes Controversial Dove Commercial Recreating Celebrities' Final Moments BUGAUP | Billboard Utilizing Graffitists Against Unhealthy Promotions
advertising, health, netherlands, public art
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Although it is set in hell, this tale is about the here and now.
The rich man and Lazarus is one of the most disturbing parables Jesus shares. Jesus does not mention hell very much, so when He mentions someone burning in hell for eternity, it merits our attention. And boy, does He have it! All we can think is I do not want that to be me. However, it is not this man's situation, or his location, that Jesus intends to be our takeaway from this story. He has something greater in mind.
The Pharisees have been heckling Jesus for spending time with the sinners of society, namely tax collectors. So Jesus responds by making the case that children of God should, like the Father, have a heart for the lost, and that means using their resources to help them. He then mentions that money, to the unconverted, is like a taskmaster. God's children must determine if they will serve it or God. The Pharisees are incensed! They have a lot of money, and they love it dearly. But Jesus lets them know they need to choose. Luke 16:15: "Then he said to them, 'You like to appear righteous in public, but God knows your hearts. What this world honors is detestable in the sight of God' " (NLT).* God will judge us, not by what we do or what we have, but by who we are.
Jesus illustrates it this way: A rich man, with fine clothing and a huge home, lived very well. Outside of his home was a beggar named Lazarus. He was so hungry that he would have gladly eaten with the dogs. Ironically, those dogs slowly ate him by licking his sores, a terrible picture.
But in Jesus' story the wrong man has a name.
We use the phrase "making a name" to mean to develop a reputation for one's self. The name a person makes may be good or bad, but it constitutes how that person is known. An affluent man would normally be the one who has made such a name. A poor beggar would likely be identified as nobody, if he were referred to at all. Surely the rich man's neighbors were well acquainted with him and called his name often. They probably placed his name on invitations as well as awards and plaques. Yet Jesus does not mention his name.
As this rich and successful man goes nameless, the poor and homeless beggar is referred to by name. Jesus turns our human conventions on their heads. While the affluent and successful have a name many humans call, there is no such automatic recognition in heaven. In God's eyes those obsessed with wealth and accomplishments have already made a name for themselves on the earth. However, those who belong to the kingdom of God have a name written in heaven.
The poor man's name, Lazarus, means "God will help" or "assistance of God." His only recourse is to depend upon the help of God. This is the reputation the poor man has made for himself in heaven. So God has a place of rest and comfort prepared for him.
The rich man spent his life depending on his own ingenuity and wealth. He had not thought to rely on God, because he was doing a great job on his own. So he became a servant of money, believing he could care for himself. While material wealth can help people establish cozy lives in the present, there is nothing money can do for us in the life to come. The poor man went to the place his "Help" prepared for him, and the rich man went to the place prepared for those who find their help elsewhere.
Jesus is not telling this parable in order to train our eyes on the hereafter, but to engage our hands and feet in the now. No doubt most of the Pharisees identified with the rich man in this parable, and saw themselves in the man doomed. Jesus' intent is to invite them, and us, to abandon pride and the worship of wealth, and to love the people God loves. Rather than allow us to carry on with our lives in ignorance, Jesus shares this truth to offer us an opportunity for course correction.
While it is too late for the man in the story, the fact that we can hear and understand the parable means we still have a chance. Jesus wants to shed light on the true condition of our hearts so that we can depend on Him to make our poisonous hearts like His. The telling of this story is an act of grace. It means that God doesn't want to see us experience the natural end that comes to those who do not depend on Him. He wants us to make a new start together. It is not too late.
Lola RENEE MOORE is a native of Elizabeth, New Jersey. She is a lover of music and literature, and enjoys extreme sports. She resides in northwest Florida, where she pastors the Maranatha and Emmanuel Seventh-day Adventist churches in Panama City and Greenwood, Florida, respectively.
They are everywhere. In the streets, buses, and gas stations. They frequent the highways and service streets. You can spot them among the crowds in a congested city. The churches are like magnets for them. Have you ever passed by someone who was homeless? I have. On my way to my climate-controlled, cushioned, comfortable accommodations I am guilty of not sparing much care for the needy. Maybe I have become numb to those who are in need of assistance or, specifically, I have been blinded by my own personal deposit of God's blessings and have become oblivious. Is there any counsel on this? Let us look to a parable Jesus told about a man who needed help.
It had been awhile since I read this parable, and as soon as I read the first verse, my attention was arrested. In the time of Jesus, to get something such as purple clothes was a tall and expensive task. It continues by saying that he lived in luxury every day. He was not just getting by—he was living in grandeur. I was tempted to judge, but if we were to take an inventory of all that is around us, we might find that in reality we need for nothing. I challenge you to sit down and write out a list of all that you need at this very moment. After you're finished, read Matthew 6:31-34 and see if you can identify what God's absolute promise of provision is.
When the rich man realizes that there is no hope for him, he thinks about his family. Many have traveled the way the world has taught us as the way to a "good life." Went to school, got a good education in order to get a good job, in order to get a good house, and to support a good family. There is nothing wrong with this picture. It is a gift of God. But has His blessing of shelter and security forged a strand of uninterest in helping those less fortunate? If the culture of love is not engrained early, it will be too late to change. I challenge you to sit your family down and talk to them about serving those less fortunate together. If you want help praying for your family, contact us here at Message. We will pray with you through this.
Rashad Burden is an associate pastor for youth at the Buckhead Fellowship chruch in Buckhead, Georgia.


From left: Escondido Mayor Sam Abed, Supervisor Dave Roberts and Encinitas Mayor Kristin Gaspar.
REGION — The first of a potential two-round political battle reaches the midway point Tuesday in the race for the District 3 seat on the San Diego County Board of Supervisors.
Incumbent Dave Roberts, a Democrat, takes on challengers Sam Abed, mayor of Escondido, and Kristin Gaspar, mayor of Encinitas, both Republicans in the primary. The supervisor seat, however, is a nonpartisan office.
Abed and Gaspar have taken Roberts to task for an office scandal and county policy violations, which cost the county $310,000 last year to settle. Roberts' lack of an explanation gave Abed and Gaspar their opening to challenge the incumbent, the pair said.
The two challengers have hammered home the allegations made by three former staffers in Roberts' office as they hope to upend Roberts Tuesday. Abed and Gaspar's attacks on Roberts' integrity and trust has been a driving force in each campaign.
Roberts, however, said his efforts on the campaign trail have produced positive feedback from voters, who he feels have moved on from the scandal.
Roberts said his opponents have yet to challenge his record in office because his efforts have produced results from mental health facilities, opposing landfills next to rivers and overdevelopment, and the county becoming one of a handful in the country to have a triple-A rating from all three credit agencies for the past four years.
His financial acumen, Roberts said, is yet another strongpoint for the incumbent.
"In 2013, the county for the first time, got a triple-A bond rating," Roberts said. "That is my strength. My strong fiscal background, working in the Pentagon on the airport budget, creating the Tri-Care Military Health Care System, which has a strong fiscal component to it.
Roberts, though, said the attacks on him are down from his first campaign running for supervisor four years ago (12 negative mailers in 2012 to eight this cycle). In addition, he was surprised at Abed and Gaspar's attacks on each other, as both have traded barbs over Abed's parking lot and Gaspar's claim of being an educator opposed to a volunteer.
Nevertheless, Roberts said his record and experience, which also includes being appointed as a health policy advisor for the administrations of presidents Barack Obama and George W. Bush, is what set him apart.
But to survive the race means questions and consistent claims of a lack of integrity for Roberts. He stressed the matter is behind him, took responsibility and said he cannot discuss the matter in greater detail as it is a confidential personnel issue.
Abed said he was the first to call for Roberts' explanation, and when none was provided, he announced his candidacy last summer. Gaspar followed in the fall and both quickly began taking shots at Roberts' credibility and integrity.
As mayor of the largest city in the district, Abed said he doesn't want a "corrupt" supervisor to represent his city, so he decided to join the race.
The challengers, meanwhile, have said little about Roberts' record on the issues up to date.
Abed stressed he is the most qualified candidate heading into Tuesday's primary and November's general election.
He said Roberts' lack of trust with the voters coupled with his crossover appeal to independents and democrats make him the strongest choice. In addition, Abed said his experience on the board of the San Diego Association of Governments (SANDAG), is another star on his record.
However, Gaspar has also chided Abed for his explanation of a controversial parking lot, which he said was targeted by the state for a lack of storm water mitigation. Abed said the matter was drummed up by a political rival during his mayoral re-election campaign in 2014, and after the city said his lot met the requirements, paid $75,000 to pave the lot to kill any speculation of wrongdoing.
In addition, Gaspar has repeatedly questioned Abed's role in the recovery of Escondido, the district's largest city. She said the city's financial health, which has seen four consecutive years of surpluses, is based more on the recovery of the economy than any policies or direction implemented by Abed.
Regarding his parking lot, Abed stressed he was in compliance with the law and gained the necessary city approvals.
"The Union Tribune … misled the public and it was media hype," Abed said, referring to a Jan. 24 article.
The lot was already "semi-paved" with crushed concrete when Abed went to the city to determine if it needed to be fully paved. The city came back to the mayor saying that it was in compliance with their standards.
Abed said his record consists of improving the bond rating to AA-, attracted nearly 1,000 new businesses to the city plus the jobs associated with those businesses, created an $8 million surplus, brought about $1 billion in investments and lowered the crime rate by 22 percent in 2014.
"This has been a major turnaround for the city of Escondido," he added. "Some people tell me it's a historic turnaround. I think that's why I will be elected to the county and nobody has that kind of record.
Abed also referred to Gaspar's stance of being an educator instead of volunteering at schools. In addition, the accusations of her mailers against Abed have struck a nerve.
Gaspar, who has positioned herself as a political moderate in the race, said she is proud of her record of fiscal conservatism and prioritization of public safety and infrastructure improvement, issues that she said cross over into the third district.
Encinitas has been able to maintain some of the best paved roads in the county, and Gaspar said she fought on the council to make fully funding road and infrastructure maintenance the council's funding priority.
In the voting minority, however, she has lost some of those battles, but Gaspar said that Encinitas has come a long way from previous councils, where voting majorities and minorities often publicly clashed at meetings.
Gaspar, however, did not back down from her criticism of Abed, calling herself the only candidate without a track record of scandal.
Should Roberts advance to the general election, he said the noise surrounding the scandal will continue, but noted how Abed and Gaspar have gone after each other.


text:
Community Health Resource Commission - Health Information Technology Grantees: Maryland
DHMH
Health Information Technology Grantees - The Maryland Community Health Resources Commission works to expand access to health care services for low-income and under-served communities across the state.CHRC's traditional grantees. Individual grantee recipients. Total grant funding values are based on 2007-2014 data.Since its inception, the CHRC has awarded 143 grants totaling $42 million through its Calls for Proposals, which have supported programs in every jurisdiction in Maryland. The CHRC has aligned its grantmaking activities to support the policy priorities of the O'Malley-Brown Administration and DHMH leadership. CHRC grants have supported programs which have provided services for 140,644 patients, resulting in 433,692 patient visits.The Maryland Community Health Resource Commissionhttp://dhmh.maryland.gov/mchrc/SitePages/CHRC%20Grants.aspxLast Updated: UnknownThis is a MD iMAP hosted service. Find more information athttps://imap.maryland.gov.Feature Service Link:https://geodata.md.gov/imap/rest/services/Health/MD_CommunityHealthResourceCommission/FeatureServer/4
Kennedyville, Maryland, Martin's Additions, Maryland, Cottage City, Maryland, Edmonston, Maryland, Clarksburg, Maryland, Edesville, Maryland, Pondsville, Maryland, Howard County, Maryland, Naval Academy, Maryland, Cloverly, Maryland, Essex, Maryland, Brooklyn Park, Maryland, Garrison, Maryland, Redland, Maryland, Baltimore, Maryland, Brownsville, Maryland, Kingstown, Maryland, South Kensington, Maryland, Indian Springs, Maryland, Pikesville, Maryland, Ilchester, Maryland, North Brentwood, Maryland, Washington Grove, Maryland, Middletown, Maryland, Georgetown, Maryland, Berwyn Heights, Maryland, Jugtown, Maryland, Fort Meade, Maryland, Annapolis, Maryland, Buckeystown, Maryland, Rosemont, Maryland, Baltimore County, Maryland, Maryland City, Maryland, Brookmont, Maryland, Big Pool, Maryland, Chester, Maryland, Charlton, Maryland, San Mar, Maryland, Hillandale, Maryland, Barnesville, Maryland, Hampton, Maryland, Edgewood, Maryland, Chillum, Maryland, Chevy Chase Village, Maryland, Downsville, Maryland, Takoma Park, Maryland, Severna Park, Maryland, Carroll County, Maryland, Chesapeake City, Maryland, Burnt Mills, Maryland, Woodsboro, Maryland, Landover Hills, Maryland, West Laurel, Maryland, Graceham, Maryland, Timonium, Maryland, Washington County, Maryland, Robinwood, Maryland, Chevy Chase Section Five, Maryland, Sykesville, Maryland, Riverside, Maryland, Myersville, Maryland, Bel Air North, Maryland, Burtonsville, Maryland, Darnestown, Maryland, Rohrersville, Maryland, Elkridge, Maryland, Still Pond, Maryland, Funkstown, Maryland, Montgomery County, Maryland, Mercersville, Maryland, Spring Gap, Maryland, Aberdeen Proving Ground, Maryland, Queen Anne, Maryland, Kemps Mill, Maryland, Seabrook, Maryland, New Market, Maryland, Allegany County, Maryland, Arden On The Severn, Maryland, St. James, Maryland, Severn, Maryland, Kent Narrows, Maryland, Stevensville, Maryland, Lutherville, Maryland, North Chevy Chase, Maryland, Gapland, Maryland, Poolesville, Maryland, Prince George's County, Maryland, North East, Maryland, Catonsville, Maryland, Lanham, Maryland, University Park, Maryland, Garretts Mill, Maryland, Bartonsville, Maryland, North Kensington, Maryland, Beaver Creek, Maryland, Kensington, Maryland, South Laurel, Maryland, Dargan, Maryland, Forest Glen, Maryland, Highland, Maryland, Colmar Manor, Maryland, Bel Air, Maryland, Aspen Hill, Maryland, Jefferson, Maryland, Kent County, Maryland, Union Bridge, Maryland, Libertytown, Maryland, Spencerville, Maryland, White Marsh, Maryland, Potomac, Maryland, Hyattsville, Maryland, Edgewater, Maryland, Ellicott City, Maryland, Antietam, Maryland, Fairwood, Maryland, Lansdowne, Maryland, Glenn Dale, Maryland, Langley Park, Maryland, Point Of Rocks, Maryland, Baltimore City County, Maryland, Braddock Heights, Maryland, Eldersburg, Maryland, Cecil County, Maryland, Barclay, Maryland, Glenarden, Maryland, Springdale, Maryland, Mount Rainier, Maryland, Fairland, Maryland, Mount Lena, Maryland, Williamsport, Maryland, Perryman, Maryland, Carney, Maryland, Arnold, Maryland, Lochearn, Maryland, Caroline County, Maryland, Cheverly, Maryland, Riva, Maryland, Trego-rohrersville Station, Maryland, Travilah, Maryland, Konterra, Maryland, Parkville, Maryland, Sudlersville, Maryland, Talbot County, Maryland, Highland Beach, Maryland, Walkersville, Maryland, Westminster, Maryland, Charlestown, Maryland, Garrett Park, Maryland, Middle River, Maryland, East Riverdale, Maryland, Perry Hall, Maryland, Harford County, Maryland, Herald Harbor, Maryland, Overlea, Maryland, Layhill, Maryland, Ernstville, Maryland, Frederick, Maryland, Towson, Maryland, White Oak, Maryland, Glen Echo, Maryland, Little Orleans, Maryland, Reisterstown, Maryland, Spring Ridge, Maryland, Queen Anne's County, Maryland, Butlertown, Maryland, Mapleville, Maryland, Bel Air South, Maryland, Cape St. Claire, Maryland, Urbana, Maryland, Boonsboro, Maryland, Linthicum, Maryland, Laytonsville, Maryland, Kemp Mill, Maryland, New Windsor, Maryland, Bowleys Quarters, Maryland, Bladensburg, Maryland, Sharpsburg, Maryland, Calverton, Maryland, Arbutus, Maryland, Centreville, Maryland, Brentwood, Maryland, Mays Chapel, Maryland, Greensboro, Maryland, Crumpton, Maryland, Lake Shore, Maryland, Millington, Maryland, Laurel, Maryland, Fairlee, Maryland, Bagtown, Maryland, North Laurel, Maryland, Four Corners, Maryland, Derwood, Maryland, Rosedale, Maryland, Chesapeake Landing, Maryland, Hillsboro, Maryland, Flower Hill, Maryland, Linganore, Maryland, Chevy Chase, Maryland, Queenstown, Maryland, Halfway, Maryland, Colesville, Maryland, Somerset, Maryland, College Park, Maryland, Yarrowsburg, Maryland, Adelphi, Maryland, Edgemere, Maryland, North Bethesda, Maryland, Chestertown, Maryland, Odenton, Maryland, Fulton, Maryland, Galena, Maryland, Fallston, Maryland, Leisure World, Maryland, Bakersville, Maryland, Dundalk, Maryland, Chevy Chase View, Maryland, Pleasant Hills, Maryland, Hampstead, Maryland, Pinesburg, Maryland, Oldtown, Maryland, Honeygo, Maryland, Ten Mile Creek, Maryland, Ridgely, Maryland, Kingsville, Maryland, New Carrollton, Maryland, Beltsville, Maryland, North Potomac, Maryland, Scaggsville, Maryland, Owings Mills, Maryland, Big Spring, Maryland, Lisbon, Maryland, Frederick County, Maryland, Montgomery Village, Maryland, Burkittsville, Maryland, Pasadena, Maryland, Columbia, Maryland, Aberdeen, Maryland, Ferndale, Maryland, Rossville, Maryland, Parole, Maryland, Friendship Heights Village, Maryland, Mount Briar, Maryland, Riviera Beach, Maryland, Glenmont, Maryland, Gaithersburg, Maryland, Port Deposit, Maryland, Anne Arundel County, Maryland, Green Valley, Maryland, Glen Burnie, Maryland, Cabin John, Maryland, Lewistown, Maryland, Crownsville, Maryland, Greenbelt, Maryland, Breathedsville, Maryland, Crofton, Maryland, Bethesda, Maryland, Monrovia, Maryland, Worton, Maryland, Havre De Grace, Maryland, Ashton-sandy Spring, Maryland, Olney, Maryland, Damascus, Maryland, Rock 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Maryland iMap


text:
'Raksha Bandhan' is my reunion with the most special people in my life!: Bhumi Pednekar
Bhumi is collaborating with Aanand L Rai, the producer of her hit film 'Shubh Mangal Saavdhan', who will be directing her in Raksha Bandhan
NH Web Desk
Published: 07 Aug 2021, 4:00 PM
Young Bollywood star Bhumi Pednekar has just wrapped the Mumbai schedule of her next titled Raksha Bandhan. Bhumi has been paired opposite superstar Akshay Kumar, their second film together after the blockbuster Toilet: Ek Prem Katha. Interestingly, Bhumi is collaborating with Aanand L Rai, the producer of her hit film Shubh Mangal Saavdhan, who will be directing her in Raksha Bandhan.
"Raksha Bandhan is my reunion with the most special people in my life! Anand Rai sir is a guru for me, who trusted my abilities as an actor when I had just started out and I will forever be grateful to him for the opportunity he gave me to shine through in Shubh Mangal Saavdhan. So, I'm delighted that I have got an opportunity to work with him again," Bhumi said.
"Akshay Kumar sir gave me a film that became my first blockbuster. He believed in me in Toilet: Ek Prem Katha and our pairing won hearts. He has instilled a sense of belief in me that has propelled me to excel in this industry. So, naturally I was thrilled when I got to know that I will be acting with him again in Raksha Bandhan," she added.
The versatile actress is confident that Raksha Bandhan will appeal to audiences of all age groups. She says, "It's a script that will touch everyone's hearts and I'm hoping that my pairing with Akshay sir will be loved again!"


text:
import numpy as np

class NumericalAlgorithm:
    pass

class NumericalIterator(NumericalAlgorithm):
    pass

class FPIterator(NumericalIterator):
    TOLERANCE = 0.5e-8
    MAX_ITER = 100

    def __init__(self, update_func, evaluate_func):
        self.updator = update_func
        self.evaluator = evaluate_func

    def __call__(self, func, guess, tolerance=TOLERANCE, max_iter=MAX_ITER):
        guess = np.asarray(guess)
        updator = self.updator(func)
        fixed_points = np.empty((max_iter + 1, *guess.shape))
        fixed_points[0] = guess
        iterations = 1

        while iterations < max_iter:
            fixed_points[iterations] = updator(fixed_points[iterations - 1])
            if self.evaluator(fixed_points, iterations, tolerance):
                break
            iterations += 1

        fixed_points = fixed_points[:iterations + 1]
        errors = np.abs(fixed_points[1:] - fixed_points[:-1])

        return fixed_points, errors, iterations

    def __str__(self):
        return self.__repr__()

    def __repr__(self):
        return "FPIterator"

def _fp_update(func):
    """
    x[i] -> f(x[i-1])
    """
    return lambda x: func(x)

def _fp_evaluate(sequence, iteration, tolerance):
    """
    |x[i] - x[i-1]| < tol
    """
    return np.abs(sequence[iteration] - sequence[iteration - 1]) < tolerance

fixed_point = FPIterator(_fp_update, _fp_evaluate)

def _newton_update(func):
    """
    x[i] -> x - f(x[i-1]) / f'(x[i-1])
    """
    return lambda x: x - func[0](x) / func[1](x)

newton = FPIterator(_newton_update, _fp_evaluate)