Welcome! Thank you for considering us as a real estate resource for buying or listing your home or property. We are experienced Realtors serving Colorado Springs and the Pikes Peak area. We are committed to serving our clients with honesty, integrity, and professionalism, and we represent our clients' needs and interests without compromise.
We are ranked in the top 1% of over 3000 Pikes Peak area Realtors for Home Listings and Sales, as well as ranked in the top 1% of all Realtors nationally. We market our clients' listings on 3 MLS systems - the Colorado Springs/Pikes Peak Area MLS, the Denver Area MLS, and the Pueblo area MLS - and on over 100 real estate sites, with exposure to 7 million buyers a month to obtain the highest sales price in the shortest amount of time. Our buyer services include an individualized buyer website linked to the MLS which automatically updates when new properties come on the market and provides property and neighborhood information 24 hours a day, 7 days a week.
We are a member of the Pikes Peak Elite 25 Group (www.elite-25.com), a select group of area Realtors that represent the top 1% of our industry, and the Peak Producers (thepeakproducers.com), a professional group with a strong motivation to give back to the community and a desire to raise the level of professionalism within the Pikes Peak Association of Realtors. Both of these organizations are national referral groups for Pikes Peak area home listings, which allows us to market our clients' listings to other top performing agents in Colorado Springs, Denver, Pueblo, and across the country.
Education is extremely important to our real estate group, as it helps us to continuously better the services and information we provide to our clients. We have earned undergraduate and graduate degrees, and the professional designation of e-Pro - a comprehensive certification for utilizing effective internet and social media real estate marketing. We also have strong relationships and key connections with area military at Fort Carson, Peterson Air Force Base, Shriever Air Force Base, United States Air Force Academy, and Cheyenne Mountain Air Force Station. Our strong military connections give our home and property listings key marketing advantages, and exposure to an estimated 188,000 military-related personnel and family members - nearly 38% of the total Pikes Peak area population.
We provide high-definition photography for our listings, and we create individual QR codes and Text codes for our properties. You can see one of our text codes in action by texting "2399461" to 79564.
We hope that you will feel free to contact us with any relocation, neighborhood, or real estate questions, even if you are not planning on buying or selling right away. We're happy to help in any way we can.


text:
Q: Can Google Calendar API be used to create scalable scheduling service? I need to create a scheduler for my own SaaS, and I'm trying to understand whether Google Calendar API is a fit for that. Basically I could have hundreds of thousands of calendars. Each calendar may be a user of my service, but not a Google user. It seems that perhaps I could use resource calendars under my Google Cloud service account. My biggest concern is whether my usage will fall within the Calendar API's service quotas, either automatically or by requesting a quota increase?

A: Yes service accounts will fall within quota usage limits.  There is also a limit about creating more then 25 calendars in a day causing the user to end up in read mode for the rest of the day.
pricing

Google Calendar API Usage Limits
The Google Calendar API has a courtesy limit of 1,000,000 queries per day.
To view or change usage limits for your project, or to request an increase to your quota, do the following:

*

*If you don't already have a billing account for your project, then create one.

*Visit the Enabled APIs page of the API library in the API Console, and select an API from the list.

*To view and change quota-related settings, select Quotas. To view usage statistics, select Usage.

A: On the one hand, you could work around the quota issues by sharding your users across multiple Service Accounts. You would probably also want to shard them across multiple App IDs.
On the other hand, don't do it. In my experience, using Google APIs outside their intended use case doesn't end well.

redpajama_set_name: RedPajamaStackExchange


text:
Tropic of Squalor: Poems by Mary Karr – Review
Tropic of Squalor: Poems by Mary Karr has an expected publication date of May 8th, 2018 by Harper Collins Publishers. A new volume of poetry from the New York Times bestselling and esteemed author of The Liar's Club and Lit.
Long before she earned accolades for her genre-defining memoirs, Mary Karr was winning poetry prizes. Now the beloved author returns with a collection of bracing poems as visceral and deeply felt and hilarious as her memoirs. In Tropic of Squalor, Karr dares to address the numinous—that mystery some of us hope towards in secret, or maybe dare to pray to. The "squalor" of meaninglessness that every thoughtful person wrestles with sits at the core of human suffering, and Karr renders it with power—illness, death, love's agonized disappointments. Her brazen verse calls us out of our psychic swamplands and into that hard-won awareness of the divine hiding in the small moments that make us human. In a single poem, she can generate tears, horror, empathy, laughter, and peace. She never preaches. But whether you're an adamant atheist, a pilgrim, or skeptically curious, these poems will urge you to find an inner light in the most baffling hours of darkness.
About the author: Mary Karr is an American poet, essayist, and memoirist. She rose to fame in 1995 with the publication of her bestselling memoir The Liars' Club. She is the Peck Professor of English Literature at Syracuse University.
Karr was born January 16, 1955, in Groves, a small town in East Texas located in the Port Arthur region, known for its oil refineries and chemical plants, to J. P. and Charlie Marie (Moore) Karr. In her memoirs, Karr calls the town "Leechfield." Karr's father worked in an oil refinery while her mother was an amateur artist and business owner.
The Liars' Club, published in 1995, was a New York Times bestseller for over a year and was named one of the year's best books. It delves vividly and often humorously into her deeply troubled childhood, most of which was spent in a gritty, industrial section of Southeast Texas in the 1960s. She was encouraged to write her personal history by her friend, author Tobias Wolff, but has said she only took up the project when her marriage fell apart. She followed the book with another memoir, Cherry (2000), about her late adolescence and early womanhood. A third memoir, Lit, which she says details "my journey from blackbelt sinner and lifelong agnostic to unlikely Catholic," came out in November 2009.
Karr thinks of herself first and foremost as a poet. She was a Guggenheim Fellow in poetry in 2005 and has won Pushcart prizes for both her poetry and her essays. Karr has published four volumes of poetry: Abacus (Wesleyan University Press, CT, 1987, in its New Poets series), The Devil's Tour (New Directions NY, 1993, an original TPB), Viper Rum(New Directions NY, 1998, an original TPB), and her new volume Sinners Welcome(HarperCollins, NY 2006). Her poems have appeared in major literary magazines such as Poetry, The New Yorker, and The Atlantic Monthly.
She is a controversial figure in the American poetry "establishment," thanks to her Pushcart-award winning essay, "Against Decoration," which was originally published in the quarterly review Parnassus (1991) and later reprinted in Viper Rum. In this essay, Karr took a stand in favor of content over poetic style. She argued emotions need to be directly expressed, and clarity should be a watch-word: characters are too obscure, the presented physical world is often "foggy" (that is imprecise), references are "showy" (both non-germane and overused), metaphors over-shadow expected meaning, and techniques of language (polysyllables, archaic words, intricate syntax, "yards of adjectives") only "slow a reader"'s understanding. Karr directly criticized well-known, well-connected, and award-winning poets such as James Merrill, Amy Clampitt, Vijay Seshadri, and Rosanna Warren (daughter of Pulitzer Prize winner Robert Penn Warren). Karr favors controlled elegance to create transcendent poetic meaning out of not-quite-ordinary moments, presenting James Merrill's Charles on Fire as a successful example.
While some ornamentations Karr rails against are due to shifting taste, she believes much is due to the revolt against formalism which substituted sheer ornamentation for the discipline of a meter. Karr notes Randall Jarrell said much the same thing, albeit more decorously, nearly fifty years ago. Her essay is meant to provide the technical detail to Jarrell's argument. As a result of this essay, Karr earned a reputation for being both courageous and combative, a matured version of the BB-gun toting little hellion limned in The Liars' Club.
Another essay, "Facing Altars: Poetry and Prayer", was originally published in Poetry (2005). Karr tells of moving from agnostic alcoholic to baptized Catholic of the decidedly "cafeteria" kind, yet one who prays twice daily with loud fervor from her "foxhole". In this essay, Karr argues that poetry and prayer arise from the same sources within us.
My thoughts: Tropic of Squalor is the fifth poetry collection written by Karr. The major theme throughout this collection of poems is death. The poems in this poem are realistic and relatable. Some can bring out different emotions for the reader. Tropic of Squalor is a book that is not for everyone but if you like plain spoken poetry that is sarcastic or sometimes rude than this is the book for you. I was not a fan of this collection. ** I received a complimentary copy in exchange for my honest and unbiased review. This post contains affiliate links and I will be compensated if you make a purchase after clicking on my links.**
Posted in: Books, Uncategorized | Tagged: HArper Collins, harper collins publisher, Mary Karr author, May 2018 book release, poetry, poetry collection
American Assassin by Vince Flynn
Dog Training the American Male by L.A. Knight – Review

redpajama_set_name: RedPajamaCommonCrawl


text:
With a slew of floor-stomping hits and sold-out shows, 2019 saw The Snuts cement their place as one of the UK's most exciting new bands. The band continue their rapid rise in 2020 with their dance-pit anthem Fatboy Slim and the release of their brand-new Mixtape EP on Parlophone Records. Packed with hooks and a groove that will drive even the most reluctant to the dancefloor, Fatboy Slim is set to be the anthem across the nation's fields this summer. Speaking of the track lead singer Jack Cochrane said: "The song is a nod to the nostalgic subculture of live music across the UK in the 90s and similar decades. Toying with the idea of sampled drum loops and an electronic music styled structure the track is intended to pay homage to Fatboy Slim's notorious set at Brighton beach almost 15 years ago".
The Snuts - Mixtape EP Released 13/03/20


Speak at Velocity 2019 in Berlin!
Call closes 23:59 — 30 April 2019 CEST.
At Velocity, we focus on teaching new skills, approaches, and technologies for building and managing large-scale, cloud native systems. Knowledge of a specific tool or technology is important, but success only happens when the people building the systems understand the context of their work as part of a larger whole and understand the interdependencies each technology has on the other.
We're seeking proposals that provide the content and context engineers need to succeed and reflect the complexity and depth of the systems that today's organizations are building and managing. Talks at Velocity are opinionated, vendor-neutral, deep-dives into the technology, tools, processes, and people needed to build modern, cloud native systems. We focus on real-world implementations, case studies, and lessons learned from both success and failure. We're interested in new tools, techniques, ideas, and experiments that will help our community learn and develop.
Note: All presentations at Velocity will be conducted in English; please submit proposals in English.


It is always tempting to judge the value of your adviser on the recent performance of your investment portfolio. That is unfair as it fails to understand the true value that a good adviser delivers (leaving aside the valuable financial planning advice that they also provide) and the fact that no manager can control the returns that the market delivers.
A good adviser will act as a foil to avoid the dangerous combination of investor emotions and bad investment ideas. They can earn their ongoing fee several times over simply by helping clients to have patience, fortitude and discipline in their investing.
In this volume of Acuity we explore the true value that an adviser can bring to your investment programme.
Based on my experience this statement is so true. If 50% of a Advisors role is to do the number crunching, the bal 50% us to be the Financial Coach. Why??? Simpky because the clients need to remain in the path to achieve their goals.So with oroper coaching you can bribg out the best from the client.
The role of investment advisor is ever emphasized by the rolling over periods that they have added into someone's business with much of success. Prior portfolio of them helps us to determine whom to go with. Professionalism should never be the constraint in picking out them. One's judgmental skill can get them the most viable advisor.


text:
Q: Sample ATL Dialog Window Can anyone help me find an up-to-date, working ATL project which has a main window and some components in it? Please, for the love of god, don't tell me to use WTL/Qt or others. I need ATL. There's no up-to-date project about it. I just need a main window, that's all. I can figure out the rest.
Thanks in advance.

A: OK, for the love of god: Visual Studio 2010 C++/ATL EXE project from template + dialog window.
Source:

*

*Trac: AtlDialogSample

*SVN: AtlDialogSample
This is of your primary interest:
////////////////////////////////////////////////////////////
// CMainDialog

class CMainDialog :
    public CDialogImpl<CMainDialog>
{
public:
    enum { IDD = IDD_MAIN };

BEGIN_MSG_MAP(CMainDialog)
    MESSAGE_HANDLER(WM_INITDIALOG, OnInitDialog)
    COMMAND_ID_HANDLER(IDCANCEL, OnCommand)
    COMMAND_ID_HANDLER(IDOK, OnCommand)
END_MSG_MAP()

public:
// CMainDialog

// Window Message Handlers
    LRESULT OnInitDialog(UINT nMessage, WPARAM wParam, LPARAM lParam, BOOL& bHandled)
    {
        ATLVERIFY(CenterWindow());
        return 0;
    }
    LRESULT OnCommand(UINT, INT nIdentifier, HWND, BOOL& bHandled)
    {
        ATLVERIFY(EndDialog(nIdentifier));
        return 0;
    }
};

and
VOID RunMessageLoop()
{
    CMainDialog Dialog;
    Dialog.DoModal();
}


text:
using RedisInside;
using System;
using System.Collections.Generic;
using System.Linq;
using System.Net;
using System.Text;
using System.Threading.Tasks;

namespace IntegrationTests.RedisClientTests
{
    public static class RedisInstance
    {
        static readonly Redis Redis = new Redis();

        public static IPEndPoint Endpoint { get { return (IPEndPoint)Redis.Endpoint; } }

        static RedisInstance()
        {
            AppDomain.CurrentDomain.DomainUnload += (s, e) => Redis.Dispose();
        }
    }
}

redpajama_set_name: RedPajamaGithub


text:
/**
 *
 */
package org.jretty.indexIgnoreCase;

/**
 *
 * @author zollty
 * @since 2018年5月29日
 */
public class Str04 {

    public static int indexIgnoreCase(String subject, String search) {
        return indexIgnoreCase(subject, search, 0);
    }

    public static int indexIgnoreCase(String str, String searchStr, int startPos) {
        if (str == null || searchStr == null) {
            return -1;
        }
        if (startPos < 0) {
            startPos = 0;
        }
        int endLimit = (str.length() - searchStr.length()) + 1;
        if (startPos > endLimit) {
            return -1;
        }
        if (searchStr.length() == 0) {
            return startPos;
        }
        for (int i = startPos; i < endLimit; i++) {
            if (str.regionMatches(true, i, searchStr, 0, searchStr.length())) {
                return i;
            }
        }
        return -1;
    }

}


2018 Household Hazardous Waste Collections are Underway!
FREE Household Hazardous Waste (HHW) collection for Town of Barnstable residents happening Saturday August 25th from 9am to noon at the Barnstable Transfer Station, 45 Flint Street in Marstons Mills.
Don't know what's acceptable? Check your 2018 HHW brochure! You can pick up a brochure at your town hall or download from our website www.loveyourlocalwater.org.
Business owners can take advantage of the opportunity to dispose of hazardous and toxic materials that can pose harm by contaminating groundwater, lakes, ponds and soil in the event of a hurricane or other emergency or inappropriate disposal. In 2017, they brought pesticides, solvents, oil-based and alkyd paints, paint thinners and strippers, and other products that can harm people or the environment.
The fee for disposal is based on the type of materials disposed of. Interested businesses can call Kalliope Chute, , Barnstable County / Cape Cod Cooperative Extension's Hazardous Materials Environmental Specialist at 508-375-6699 for more information on how to participate.


Early, early this morning, because it was a full moon and I am not a night person in ANY way, I did a little candle ritual to get rid of this negative energy that's been clinging to me like a second skin lately. I also saged myself and my house, and left all my crystals outside to charge in whatever glimpse they might have gotten of the moon through the thick fog that blankets the coast in the summer months. Yeah, I do all of that stuff. I've been listening to podcasts about magic and manifestation (they aren't all that different, to be honest), I've been reading books about mindfulness and journaling. I also started taking magnesium, because I've heard it is effective at easing depression. I've seen my therapist, I've gone to meetings, I've reached out to friends. In short, I have used almost every weapon in my arsenal to yank myself out of this funk I have been in. There are two things that I haven't done- well, one, as of yesterday- and they are these: Take TRUE action and take medication. I don't happen to have any medication laying around to take, obviously, but I am not averse to doing such a thing- going to my doctor and saying "Hey, nothing I am doing is working. I need some help.", but I will tell you this, it is the very last thing I ever want to do. I've been lucky so far and it hasn't come to that, but rest assured, if it did, I would do what I needed to do. I would never shame someone for needing that kind of help. Depression is an endless-seeming nightmare, and I wouldn't wish it on anyone. Everyone I've spoken to about the way I'm feeling inevitably asks the same question- "Why are you depressed? What's wrong?" And it is almost funny, but not really, because…seriously? That isn't how depression works. And I don't know. There's nothing wrong, nothing has changed, I just feel awful and I can't shake it. Trust me, I'm TRYING.
Taking TRUE action though, the other thing I hadn't done until yesterday, I know isn't an option for everyone who is clinically depressed. I don't think that's what I am, although I certainly have potential (the one instance where not living up to my potential is a good thing!). I am more like…lightly depressed. A salad with a side of depression. Still showering, still getting dressed when necessary, just really upset about having to do those things. So, for ME, I know that if I can just get myself moving, I will probably feel better. Only I don't want to do that. I want to sit here, in my robe, with my hair in a fraying braid, eating ice cream out of the container and watching "Crazy Ex-Girlfriend" with the blinds closed.
As woo-woo as I am, you won't find it hard to imagine that I strongly believe in synchronicity, and messages from the Universe coming through in any way that they can. Just Do It. From two people who care about me, two people who couldn't be more unlikely to have conspired behind my back to get this through to me.
Yesterday, after work, instead of slipping into my couch-coma as I am wont to do, I grudgingly put my shoes on and ordered my small child and my dog into the car. I drove to the beach, and I grudgingly got out of the car, ordered my whining child and super excited dog out of the car, and trudged morosely up the hill and over the dunes. It was freezing cold and super windy, and for some reason, by the time we made it down to the water, both of us humans were smiling. The dog was smiling the entire time, of course. We didn't go far or stay long, but that wasn't the point. The point was just to do it. By the time we got back to the car, my ears hurt like hell from the cold wind, but I felt…alive. As if I were actually existing inside my body and life, rather than from somewhere outside of it.
We went to Petsmart, bought some dog shampoo and a big bone for Lucy, and when we got home I gave her a bath. She hasn't had a bath in several months- the only one who hates her bath more than I do is her- but I was bound and determined to do it, and I did. She was such a good girl- she got right into her little tub and lay down, and I used a pitcher to rinse the filth off of her. When she was done, I dried her with a towel, and she pranced around, feeling pretty, the way dogs do after a bath. Five seconds before she went and rolled in the dirt out back. Goddammit.
The point here is, I did some things. And after I'd done them, I felt better. I took myself out to dinner, alone, and had a smashing time. I was in bed by nine, and that's okay, too. So now, my job is not to lose my momentum. I'm not out of the woods yet. As soon as I hit publish on this bad boy, I'm throwing on some yoga pants and heading out for a little while- back to the beach, and then to a meeting.
Do I believe in my candle rituals and manifestation boards and crystal energy? Do I believe that my prayers are heard and that meditation helps, and that talking about what is wrong matters? YES. I believe all of that. But I also believe that we need to meet the Universe, meet God, meet whoever or whatever is out there halfway. Whether that means asking our doctor for help with our brain chemistry, or getting up and out of the house, putting away the ice cream and opening the blinds- that's a personal decision. We can't just wait for miracles to fall out of the sky.
There are lots of messages, we just aren't always listening.
I liked your message. I'm happy you decided to get up and do something. So cool!
This is so relatable. I'm rooting for you, girl!


Bright and attractive, a stylish pair of earrings that is sure to uplift the overall look. The earrings have a round yellow fabric piece with a butterfly charm at the top and shell charm at the bottom. This pair is handmade and is light-in-weight making it perfect for all day wear.


Learn about leading your horse, safe tying, and grooming your horse before you begin you ride . You will learn basic horseback riding tips by mounting the horse, leading it to walk, reining, trotting, jogging, or to lope and other related tips .
On mounting your horse, make sure that your horse stands still quietly . It is not suggested to mount on closed areas with low headrooms and is better suggested to have it on open areas.
To prevent your foot from being caught in the stirrup if ever the horse gets upset, you should keep your heels down while horseback riding . You should observe proper body mechanics by keeping your head and shoulders up, sit straight or lean slightly .
It gives you the secure position for riding .
A good horseback riding tip tells you to be in charge of your ride, and wear sturdy boots. To feel alight contact between your hands and the bit, gather your reins . Clutch the body of the horse near the girth area by both using your legs. The same time you cue with your legs, cue with your seat by leaning forward evenly with your seat muscles .
While trailing, you should gauge the direction you will direct your horse. Maintain your agility and balance should be stable.
An additional horseback riding tip is to cue for a halt, close your fingers and squeeze backward . When the horse felt the backwards pull on the reins, the horse will stop . If the horse is hesitant to stop, you have to apply a firmer, stronger aid, tugging towards the rear.
These are a few of the horseback riding tips to see the safest way while trailing .


text:
Les eleccions legislatives portugueses de 1987 es van celebrar el 19 de juliol, i com a les de 1985, va vèncer el partit de centredreta PSD, liderat per Aníbal Cavaco Silva, que va romandre al càrrec de Primer Ministre de Portugal. A aquestes eleccions el PSD assolí la seva primera majoria absoluta a l'Assemblea de la República Portuguesa.

Resultats

Enllaços externs
 Comissão Nacional de Eleições

1987
portugueses de 1987

redpajama_set_name: RedPajamaWikipedia


Buffalo State hasn't had a rowing team in over four decades. It was 1975 when the Westside Rowing Club – the facility which the team used – burnt to the ground. The facility was rebuilt shortly thereafter, but rowing never returned to Buffalo State.
A group of faculty members and students are pushing for the return of rowing to Buffalo State. Sue McCartney, director of the Small Business Development Center and William Durfree, a chemistry professor, are working to gain support for the return of a rowing program.
Due to Title IX, the school could only field a varsity women's team, but there are talks of also creating a men's club team.
A group of students, professors and others from the campus community took a tour of the West Side Rowing Club facility on Porter Avenue in Buffalo this past March.
Canisius College, D'Youville College and many area high schools field rowing teams which use WSRC's facilities.


There is so much damn talent in the Boomer pool. As part of that generation, I'm continually fascinated by the number of us who have zero interest in really retiring. Sure, most want to get out of the structure and politics of Corporate USA, but they aren't ready to drive a golf cart around the Villages in Florida yet – they want to share their brain power and get paid for it.
Many execs I talk to are fascinated with the prospect of becoming a business coach or a consultant specific to their field of expertise – be it operations, leadership, sales or marketing. Some get even more granular and are industry specific such as finance, manufacturing or insurance. They want the flexibility, they want to choose who they work with, and they want to feel like they have purpose – that they are creating a legacy.
The roadblock happens when they actually have to launch a business and market themselves. Most stop at this point and determine it's not worth the effort – they become overwhelmed and either stick with their job for another 10 years or head to Boca and become snowbirds.
It's not that difficult to make the transition. It's a process.
The key is to flesh out your biz idea while at your current job. Let's actually find out what your target client profile is, what you will charge, what your capacity is, and hell – let's land a few clients. In other words – let's try it before you commit.
You do need to be a biz owner – so you have to set up an LLC, get insurance, hire an accountant and an attorney, manage the books and pay taxes – oh and find damn health insurance which is often a big expense. If you can ride the health insurance coattails of a spouse or partner – that's a win!
You do need to market yourself and be a salesperson. This is the part where most execs melt down – but deep breath, this isn't all that difficult. No need for a 5 figure website and fancy branding package to start – let's first see if you like it. Next, we start with your current network – there is a ton of low hanging fruit to tap into for your first clients. Once you've decided to go forward, setting up a simple website and building out content, nurturing your pipeline and clients will be important. That's Phase 2 and you can always outsource that part – marketing is a revenue generator not an expense.
I've coached countless people through this process with grand results. Plus, I'm one of "those" – I left my corporate job to become a biz coach and marketing consultant/implementor. In other words – I've been in your shoes.
If you aren't ready to retire – don't. Consider the consultant gig – it's beyond rewarding on so many levels. Legacy type rewarding – you are literally will change lives and make a great living doing it…on your terms since YOU are the CEO.


text:
Understanding the correlation between anger and violence
On Behalf of The Law Office of Joshua P. Fink, LLC | May 5, 2021 | Firm News
Explaining violence and irrational response to emotions is something that many people cannot do. Especially if specific influences in their life have compromised their understanding of controlling their emotions. Even though charging someone with domestic violence may...
What are drug schedules?
On Behalf of The Law Office of Joshua P. Fink, LLC | Apr 12, 2021 | Firm News
As explained by the United States Drug Enforcement Agency (DEA), drug schedules help categorize intoxicating substances. Accordingly, drug schedules often play a role in the type of sentence a person receives if convicted for drug possession or use. Drug schedules...
What are standardized field sobriety tests?
On Behalf of The Law Office of Joshua P. Fink, LLC | Mar 29, 2021 | Firm News
Officers have many tools they can use to potentially measure sobriety levels. One of them is the field sobriety test. This is often the first thing you will experience if an officer suspects you are driving under the influence. But what is a standardized field...
How do you differentiate shoplifting addiction from kleptomania?
On Behalf of The Law Office of Joshua P. Fink, LLC | Feb 28, 2021 | Firm News
Recently, Alaska law enforcement arrested you for shoplifting. While waiting to determine the depth of your criminal charges, you may still feel the urge to steal things that do not belong to you. Black Bear Lodge describes how an impulse-control condition differs...
The difference between assault and battery
Any connoisseur of crime shows is likely familiar with the phrase, "you are being arrested for assault and battery." Because of the prevalence of crime dramas mentioning assault and battery in the same breath, it is not uncommon for people to think that these are the...
What should I do if falsely accused of domestic violence?
On Behalf of The Law Office of Joshua P. Fink, LLC | Feb 4, 2021 | Firm News
Hearing that somebody is accusing you of domestic violence can be very shocking. However, it is paramount that you keep your emotions in check during this difficult time. Failure to do so can land you in a lot of trouble. It is also important that you act quickly and...
Can I abuse someone when having a blackout?
On Behalf of The Law Office of Joshua P. Fink, LLC | Nov 10, 2020 | Firm News
If you struggle with alcohol dependence, you may find yourself facing outlandish accusations. Your spouse may accuse you of domestic violence or other people may report infidelity and other out-of-character behaviors. You may have no recollection of this at all, but...
What are the penalties for marijuana possession in Alaska?
On Behalf of The Law Office of Joshua P. Fink, LLC | Sep 15, 2020 | Firm News
Alaska has some of the most lenient marijuana laws of any U.S. state. When it comes to possession and sharing for personal use, adults who are at least 21 years old are allowed to have up to one ounce on their person a any given time. It is, however, still possible...
Understanding protective orders in Alaska
On Behalf of The Law Office of Joshua P. Fink, LLC | Aug 9, 2020 | Firm News
If you have been accused of some form of abuse or violence against a partner or family member in Alaska, you may want to understand how these allegations may impact your life. Depending on the nature of your situation, the other party in the dispute may attempt to get...
Domestic violence charges and child custody
On Behalf of The Law Office of Joshua P. Fink, LLC | Jul 9, 2020 | Firm News
On our blog, we have covered some of the reasons why people accuse others of domestic violence (even though these allegations are completely baseless, in some instances). Child custody is one of the most common reasons why people come up with false domestic violence...


Uptown Jazz Dallas Live at House of Blues (Debut Set) - THE JAZZ NETWORK WORLDWIDE "A GREAT PLACE TO HANG"
Rules for Discount: To receive the discount you must RSVP on UptownJazzDallas.com. To RSVP you must be a logged-in Member of UptownJazzDallas.com.
The RSVP list will be at the door the night of the event. You must present a valid ID and must be minimum age of 18.
For more information about Uptown Jazz Dallas Live at House of Blues visit the Info Page here.


Our stylish European inspired pointed flap envelope constructed from cover weight paper giving it the heft and importance in a size that no one will ever ignore. In the perfect red; strong, clear and exciting.
Size- 9" x 11 1/2"


text:
Christmas: Pope Sues For Peace In Yemen, Syria And Other Flashpoints
Pope Francis used his Christmas message Tuesday to appeal for peace in conflict zones such as Syria and Yemen, whose populations face some of the world's worst humanitarian crises.
"My wish for a happy Christmas is a wish for fraternity. Fraternity among individuals of every nation and culture. Fraternity among people with different ideas… Fraternity among persons of different religions," he said in his traditional "Urbi and Orbi" (To the City and to the World) address in Saint Peter's Square.
The pontiff said he hoped a truce in conflict-ravaged Yemen would end a devastating war which has killed around 10,000 people since 2015 and pushed 14 million Yemenis to the brink of famine.
READ ALSO: 43 Killed, Dozens Injured As Gunmen Attack Government Compound In Kabul
"My thoughts turn to Yemen, in the hope that the truce brokered by the international community may finally bring relief to all those children and people exhausted by war and famine," he said.
The Pope also evoked the war in Syria, from where US President Donald Trump has decided to pull out some 2,000 troops in a controversial decision, arguing that the Islamic State has been defeated.
"May the international community work decisively for a political solution… so that the Syrian people, especially all those who were forced to leave their own lands and seek refuge elsewhere, can return to live in peace in their own country," he said.
He also said he hoped for renewed peace talks between the Israelis and Palestinians "that can put an end to a conflict that for over 70 years has rent the land chosen by the Lord to show his face of love."
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John Napier (eller Neper), född 1550 på Merchistons slott nära Edinburgh, död 4 april 1617, var en skotsk matematiker, logaritmernas och e uppfinnare. Han var far till Archibald Napier, 1:e lord Napier.

Napier deltog ivrigt i de religiösa striderna och var därvid en av presbyterianismens varmaste anhängare. På lediga stunder sysselsatte han sig med teologiska och matematiska studier. Mest känd har han blivit genom upptäckten av logaritmerna, en upptäckt, som döden dock hindrade honom från att göra fullt fruktbärande för vetenskapen. Hans uppfinning offentliggjordes i Mirifici logarithmorum canonis constructio (1614) och utvecklades vidare i den efter hans död utgivna Mirifici logarithmorum canonis explicatio (1619). För övrigt är Napier bekant som upptäckare av de efter honom benämnda Napiers (Nepers) analogier inom sfärisk trigonometri samt Napiers (Nepers) räknestavar. En av honom i handskrift efterlämnad uppsats, De arte logistica, gavs ut 1839.

Som teolog gjorde Napier sig känd genom sin kommentar av Uppenbarelseboken, A plaine discovery of the whole revelation of Saint John (1593), uppställd i strängt matematisk form med postulat, propositioner och bevis. Den 26:e propositionen innehåller, att påven är antikrist. På ett annat ställe leder han i bevis, att världen måste förgås mellan åren 1688 och 1700.

Privatliv
Napiers far var Sir Archibald Napier av Merchiston, och hans mor var Janet Bothwell, dotter till politikern och domaren Francis Bothwell och syster till Adam Bothwell som blev biskop av Orkney. Archibald Napier var 16 år gammal när John Napier föddes.

Som traditionen bjöd vid tidpunkten fick John Napier en privat utbildning och saknade formell utbildning fram till att han var 13 år gammal, då han skickades till St Salvator's College, St Andrews.

Han stannade inte på universitetet särskilt länge. Man tror att han hoppade av utbildningen i Skottland och möjligtvis reste utomlands för att söka bättre studier. Men detaljerna kring dessa år är vaga. Det finns dock ett brev bevarat från den 5 december 1560, från hans morbror Adam Bothwell till hans far, där det stod "Jag ber dig att sända John till skolorna i antingen Frankrike eller Flandern, ty han kan inte lära sig någonting hemma", och det antas att detta råd följdes.

År 1571, då Napier var 21 år gammal, återvände han till Skottland och köpte ett slott i Gartness 1574. Efter faderns död 1608 flyttade han med sin familj till slottet i Merchiston i Edinburgh, där han blev kvar resten av livet. Han dog vid 67 års ålder.

Referenser

Noter

Källor

Externa länkar

Skotska matematiker
Alumner från Saint Andrews-universitetet
Matematiker under 1500-talet
Matematiker under 1600-talet
Personer i Skottland under 1500-talet
Personer i Skottland under 1600-talet
Personer från Edinburgh
Födda 1550
Avlidna 1617
Män
Ugglan


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How Climate Legislation Failed
Ryan Lizza has a big piece in the New Yorker about the failure of climate legislation to move forward this year, and it's worth a read. But I agree with Jonathan Zasloff: if you come away thinking that the White House is mainly at fault here, you've taken away the wrong message.
Quick summary: early on there were two possible strategies for getting a bill through the Senate. The first was to round up four or five Republican supporters, since everyone knew there were at least a few Democrats who would never come on board. That never really went anywhere because there just weren't any. In the end, Lindsey Graham was the only Republican willing to support a climate bill.
So then there was Plan B: get industry groups on board, and hope that they could put pressure on Republicans to do the right thing. So John Kerry, Graham, and Joe Lieberman (collectively KGL) went to work. They got the Chamber of Commerce
on board by promising to preempt EPA regulation. They got T. Boone Pickens on board by promising a bunch of tax incentives for natural gas. They got the big oil refiners on board — for a few weeks, anyway — by agreeing to remove refineries from the cap-and-trade regime and instead have them pay something called a "linked fee."
Along the way there were some screwups. The White House unilaterally agreed to support $54 billion in nuclear loan guarantees. Then the EPA agreed to slow down its plans to regulate carbon. Finally, at the end of March, Obama announced a plan to allow more offshore drilling. All of these are things that KGL wanted to hold in reserve as bargaining chips with wavering Republican senators. But even so, they kept plugging away until April, when a White House source apparently told Fox's Major Garrett that Obama opposed the linked fee. Graham's policy aide, Matthew Rimkunas, emailed Lieberman's aide, Danielle Rosengarten:
The subject was "Go to Fox website and look at gas tax article asap." She clicked on Foxnews.com: "WH Opposes Higher Gas Taxes Floated by S.C. GOP Sen. Graham in Emerging Senate Energy Bill." The White House double-crossed us, she thought. The report, by Major Garrett, then the Fox News White House correspondent, cited "senior administration sources" and said that the "Obama White House opposes a move in the Senate, led by South Carolina Republican Lindsey Graham, to raise federal gasoline taxes within still-developing legislation to reduce green house gas emissions." Including two updates to his original story, Garrett used the word "tax" thirty-four times.
"This is horrific," Rosengarten e-mailed Rimkunas.
"It needs to be fixed," he responded. "Never seen [Graham] this pissed."
A week later Graham had pulled out and the bill was effectively dead. And there's not much question that Obama didn't help matters much. But Jonathan identifies the key passage from the story, which took place months before any of this other stuff:
Back in Washington, Graham warned Lieberman and Kerry that they needed to get as far as they could in negotiating the bill "before Fox News got wind of the fact that this was a serious process," one of the people involved in the negotiations said. "He would say, 'The second they focus on us, it's gonna be all cap-and-tax all the time, and it's gonna become just a disaster for me on the airwaves. We have to move this along as quickly as possible.' "
That's it. I've long thought that Obama's approach to climate change was woefully inadequate, but even if Obama had done everything in his power to move climate legislation forward there's simply no evidence that it would have worked. With public support so weak, one story on the Fox News website was enough to sink Graham's support. If it had ever gotten to the point of being treated to the kind of 24/7 Fox treatment that Graham was afraid of — and it would have — there isn't a single Republican who would have touched the KGL bill with a bargepole. Industry "support," which mostly means only that they would have been slightly less vicious in their opposition than usual, would have meant nothing. There would have been no Republican support. Period.
Lizza's piece is a good one, and it's worth reading the whole thing. But be sure to back away from the trees occasionally to take stock of the forest. All of the insider byplay is interesting in a human sort of way, but underneath it all it's clear that the bill simply never had a chance. No conceivable combination of policies and giveaways would have produced 60 votes. It's time for Plan C.1
1Also known as Plan EPA. I think history's ultimate judgment on Obama will depend on whether he has the guts to lend his support to a strict EPA enforcement plan that might, in the end, finally force the Senate into action. Stay tuned.


I have a coworker who I go fishing with on a regular basis. He told me that he was interested in buying a fishing rod holder so that he had a place to store his rods when they are not in use. The only requirements that he needed was a place to hold six fishing poles, a net, his cooler, and a small storage area for miscellaneous items. He searched high and low for something that would fit his requirements, but was unable to find anything that was to his liking. I told him that I would design one with Sketchup (Plans available here) and see how he liked it. So I spent a few hours making this prototype. Needless to say, he was thrilled with my design and asked me to make it for him. I agreed and told him that since he was a coworker, I would do my best to keep costs down. I normally don't try to make large items from pallet wood, but I made an exception this time because I found some extra long pallets that would allow me to avoid the dreaded nail holes typically found in items made out of pallet wood.
I used this opportunity to brush up on some woodworking skills that I have not practiced before. The drawer on this fishing rod holder features dovetail joints on the front. I have never tried to make a dovetail before. I know they did not turn out perfect, but I do think they are fairly good for a first attempt. I also felt like the nature of this project would let me practice my smoothing with a hand plane. Since the sides and shelves were glued together, there were many uneven edges. I used my kanna (Japanese hand plane) as much as possible but the lack of a workbench made this task extremely difficult. All in all, I believe that the project turned out very well and I think that my coworker will be pleasantly surprised with the fishing rod holder.
If you want to stay up to date with my projects, subscribe to my YouTube channel or my Facebook page.
I used your plans it was a great guide for me. I'm almost finished with my rod holder. I made it a bit bigger with a few modification because I use alot of big reels. When I'm finished I would like for you to see it. My email is below.
Norman, I'm glad the free plans helped you out. I would love to see your fishing rod holder and the modifications you implemented!


Once in a Lifetime Opportunities come about only once, and the opportunity to take a lap around the world strikes me as the ultimate example. Casting aside all that is familiar and comfortable is a scary step off the edge, though in the most exhilarating of ways. The short and tenuous nature of our time in this world is something that I'm acutely aware of, and at the end of this life's journey, I want to be able to look back and believe in my heart of hearts that all was left on the table, nothing held back in reserve and that it was indeed a life well lived. I'm quite certain that all the trappings of the good life will be here when I return and I am equally confident that the love and support of family and friends will accompany my every step of this journey. If not now, then when?
And for those not familiar with the spirit of the Bojon way, it is so eloquently detailed at www.bojon.com/tao and nicely captures the essence of this adventure. The explanation behind Uncle Velvet is a whole other story, best told over a beer. Pick a spot on the globe to meet me, and I'll fill in all the blanks.
I'll be back before you know it!


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Grant Golden Taylor Funk Nathan Cayo Chris Clover Jared Bynum Charles Brown Jr. Sports Men's college basketball College basketball Basketball College sports Men's basketball Men's sports
Brown Ivy Richmond Atlantic 10 Saint Joseph's
Saint Joseph's rallies late to beat Richmond 74-70
- Jan. 24, 2019 05:12 AM EST
PHILADELPHIA (AP) — Charlie Brown Jr. had 31 points and 14 rebounds, and Saint Joseph's rallied late to beat Richmond 74-70 on Wednesday night.
The Hawks trailed by as many as 14 points early in the second half, and were down seven with about four minutes left. Brown scored six straight points and Taylor Funk hit a 3-pointer to cap a 9-2 spurt that tied it 70-70 with 38 seconds to play. Funk then blocked Grant Golden's layup attempt on the next possession to set up a pair of Jared Bynum free throws with a second left. Brown added two more free throws after forcing another turnover.
Brown was 9-of-21 shooting from the field, made five 3-pointers and all eight of his free-throw attempts. Funk and Bynum finished with 12 points apiece. Chris Clover chipped in with nine points and 10 rebounds for Saint Joseph's (9-10, 2-5 Atlantic 10 Conference), which has won two of three since snapping a four-game skid.
Golden scored 24 points and Nathan Cayo added 21 to lead Richmond (7-12, 1-5).


text:
Maria Anna von Jesus de Paredes (, * 31. Oktober 1618 in Quito; † 26. Mai 1645 ebenda) war Mitglied im Dritten Orden des heiligen Franz von Assisi und Mystikerin. Sie wird in der katholischen Kirche als Heilige verehrt.

Leben
Maria Anna von Jesus stammte von vornehmen spanischen Eroberern ab, verlor sehr jung ihre Eltern und wurde von ihrer verheirateten Schwester erzogen. Beim Empfang der ersten heiligen Kommunion im Alter von sieben Jahren legte sie das Gelübde ewiger Jungfräulichkeit ab. Sie führte im Haus ihrer Schwester ein eremitisches, ausschließlich dem Gebet gewidmetes Leben und ging fast nur zum Empfang der Sakramente aus dem Haus. Mit 14 Jahren gelobte sie ein Leben nach den evangelischen Räten und wurde am 6. November 1639 in den Dritten Orden der Franziskaner aufgenommen. Die Heilige wurde wegen ihrer mystischen Erfahrungen und Prophezeiungen bekannt. Sie besaß auch die Gabe der Unterscheidung der Geister.

Maria Anna von Jesus starb am 26. Mai 1645, nachdem sie sich Gott als Sühneopfer für die Errettung der Stadt Quito vor der Pest angeboten hatte. Ihre sterblichen Überreste wurden in der Jesuitenkirche des hl. Ludwig zu Quito beigesetzt.

Seligsprechung und Heiligsprechung
Am 20. November 1853 wurde sie durch Papst Pius IX. selig- und am 4. Juni 1950 durch Papst Pius XII. heiliggesprochen. Maria Anna von Jesus ist die erste Heilige der franziskanischen Familie in Lateinamerika. Am 30. November 1945 wurde sie vom Parlament zur Heldin des Vaterlandes erklärt. Ihr Gedenktag ist der 26. Mai. Sie ist Schutzpatronin von Ecuador.

Literatur

 Wilhelm Schamoni: Das wahre Gesicht der Heiligen. Stein am Rhein 1966. S. 220, 221. Mit Imprimatur. ISBN 3-7171-0598-1
 Stefan Samerski: Individuum und Beatifikation – Juan del Castillo und die seliggesprochene Nationalpatronin von Ecuador, Maria Anna de Jesús de Paredes y Flores. In: Reimund Haas, Eric W. Steinhauer (Hrsg.): "Die Hand des Herrn hat diesen Weinberg angelegt und ihn gepflegt." Festgabe für Karl Josef Rivinius SVD (= Theologie und Hochschule. Heft 1). Verlagshaus Monsenstein und Vannerdat, Münster 2006, ISBN 978-3-86582-359-5, S. 15–27.

Weblinks

 Biografie auf Deutsch im ök. Heiligenlexikon
 Biografie im Kirchenlateinischen Wörterbuch Seite 501

Mystiker
Heiliger (17. Jahrhundert)
Jungfrau
Eremit
Franziskanerin des dritten Ordens
Ecuadorianer
Geboren 1618
Gestorben 1645
Frau


Let's say your client is a bank based outside of Ohio, and suppose further your client wants to set up a banking business in Ohio.
Last year, the Ohio Legislature made a number of important changes to Ohio's statutory banking code. These are the first comprehensive changes in more than twenty years. Most of the changes were effective January 1, 2018.
The heavy lifting of the new Ohio banking bill is language that consolidates a number of existing financial institution charters into one single charter. Going forward, Ohio-chartered banks, savings and loans and savings banks will be operating under one common form of charter.
On September 26, 2016, Rep. Armstutz introduced two pieces of legislation in the Ohio House that could impact the tax rate of the Ohio financial institutions tax ("FIT") that is paid by banks and other financial institutions doing business in Ohio. These bills are H.B. 599 and H.B. 600. These bills are alternatives. Both would not be enacted.
The FIT took effect starting in 2014 and replaced the Ohio corporate franchise tax and dealers in intangibles taxes on financial institutions. Sometimes when a new tax is introduced to replace an existing tax, there are tax rate adjuster provisions in the legislation that are designed to "right-size" the tax rate over time to generate approximately the same amount of revenue as the old tax generated, or to generate a certain targeted amount of revenue for budgeting purposes.
H.B. 599 would delete the future rate adjuster provisions entirely that are set to be calculated during 2016 that would either increase or decrease the rates for years 2017 and thereafter. Under H.B. 599, the current rates would continue indefinitely.
On September 9, 2016, the United States Court of Appeals for the Sixth Circuit issued a decision that parties in foreclosure proceedings should read carefully. In MSCI 2007-IQ16 Granville Retail, LLC v. UHA Corporation, LLC, Case No. 15-3524, the court addressed whether the sale of foreclosed property during the pendency of an appeal moots the appeal. The court's answer? Yes, at least under the facts of this case.
Plaintiff MSCI 2007-IQ16 Granville Retail, LLC ("MSCI") obtained summary judgment in this commercial foreclosure case that was filed in federal court because of diversity of citizenship between the parties and the fact that the four commercial properties at issue were located in three different counties. The United States District Court for the Southern District of Ohio (the "District Court") issued an in rem judgment entry and decree in foreclosure, finding that Defendant UHA Corporation, LLC ("UHA") owed MSCI more than $13 million on the defaulted loan at issue. UHA timely appealed, alleging a number of errors by the District Court.
Legislation has been introduced in the Ohio House that would amend Ohio's foreclosure law in a manner favorable to licensed auctioneers and realtors and unfavorable to county sheriffs and appraisers. As set forth below, House Bill 586 would, among other things, permit "private selling officers" to conduct judicial sales of real property; permit written or electronic bidding; eliminate the requirement that judgment creditors or lienholders who appear in an action pay deposits and eliminate the three-freeholder appraisal. The bill was introduced on June 17, 2014, and proposes amendments to O.R.C. §§2329.151, 2329.17, 2329.18, 2329.19, 2329.20, 2329.271, 2329.28, 2329.34, and 2329.39 and would enact new sections 2329.152 and 2329.311.
Earlier this month the Supreme Court of Ohio resolved a split of authority between the Fifth District and Seventh District regarding whether a foreclosure decree is a final appealable order when it includes unspecified amounts advanced by the mortgagee for inspections, appraisals, property protection and the like. Prior to the May 15 decision in CitiMortgage, Inc. v. Roznowski1, it was unclear whether a judgment decree of foreclosure – which typically includes unspecified amounts that may be advanced by the mortgagee prior to confirmation of the foreclosure sale for inspections, appraisals, property protection and maintenance – is a final appealable order, or whether a foreclosure defendant must wait until after the property has been sold at sheriff's sale and the order of confirmation of sale issued before he or she may appeal.
From time to time we like to pass along educational opportunities that may be of interest to our subscribers. I am including details on an upcoming event that members of our Appellate and Supreme Court Practice are offering on the benefits of amicus advocacy before the Ohio Supreme Court.
Too often, the Ohio Supreme Court decides issues that affect an industry statewide without first having heard from the industry itself. Trade associations and companies can fill this gap by filing "friend of the court" briefs in Supreme Court cases that affect them. To learn more about how your organization can be part of this process, please join Kathleen Trafford, Brad Hughes, and Dennis Hirsch of our Appellate Practice Group on April 8, 2014 for a breakfast briefing. Using a roundtable format, they plan to cover the benefits of amicus advocacy, strategies for effective amicus advocacy, and the rules governing "friend of the court" briefs.
Ohio is now one of a number of states with a so-called "asset protection" statute. Bankers with trust authority might view this development favorably because it may be another possible service line, and indeed Ohio trust companies and Ohio trust lawyers were the main proponents of the statute. Other bankers however, may encounter the statue as a roadblock in their collection efforts, to their dismay. The new statute was effective March 27, 2013.
Essentially, the statue creates another way to attempt to shield assets from creditor claims. Traditional spendthrift trusts provide such a shield, as does the incorporation of a business or the formation of a limited liability company. There are continuing questions about the effectiveness of asset protection trust statutes like the Ohio Legacy Trust Act. More on this later.


The University of Birmingham welcomes applications from students from Egypt. A growing number of Egyptian students are studying undergraduate and postgraduate programmes at Birmingham in a range of disciplines.
We are proud to be amongst the world's top 100 universities, renowned for changing lives and transforming society; therefore we are here to provide you with information and support at any time before you join us in September. Whether you are considering an Undergraduate or Postgraduate degree, do get in touch with your questions. We look forward to hearing from you and assisting you in any way we can.
You will need to demonstrate a certain level of English in order to meet the demands of your programme. If English is not your first language, you will be required to provide evidence of an English Language qualification such as IELTS, TOEFL, PTE or alternative qualifications.
Applicants from Egypt generally require either A levels, an IB Diploma or successful completion of the Foundation Pathway Programme in order to be considered for entry to the first year of an undergraduate degree programme. We can also accept alternative recognised foundation programmes - please refer to the UK page.
Holders of a bachelor degree from a recognised university with a 60-74% will be considered for entry to pre-masters programmes.
Holders of a good bachelor degree from a recognised university with a minimum of 3.0/4.0 or 75% will be considered for entry to postgraduate taught programmes.
For postgraduate research programmes applicants should hold a good Bachelor's degree and a Master's degree, ideally with 3.0/4.0 or 75% from a recognised institution. PhD applications will be considered on an individual basis.
Find out more about fees and funding for undergraduate study and postgraduate courses.


text:
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text:
siRNA Delivery: Current Trends and Future Perspectives
Authors: Singh, Manu Smriti, and Dan Peer
Journal: Therapeutic Delivery
DOI: 10.4155/tde.15.88
Publication - Abstract
Genetic Medicine Nucleic Acid Lipid Nanoparticles siRNA
Delivery of therapeutic nucleic acids in general and small interfering RNAs (siRNAs) in particular although a relatively nascent area of research, has already overcome several technical and regulatory hurdles over past few years. Some lead formulations undergoing clinical evaluation against wide range of diseases from age-related macular degeneration (AMD) to hypercholesteremia, amyloidosis and cancer. Roughly 4000 diseases are associated with malfunctioning genes in a particular cell type. Gene therapy provides opportunity to modify (inhibit or enhance) the expression of disease-causing genes at the cellular level. Gene correction at the DNA level poses risks of inciting mutations or teratogenicity in comparison with RNA interference (RNAi) approach, which works at the transcription level leading to desired outcomes at the protein production stage such as therapeutic gene silencing of a cancer-causing gene.
Currently, the key molecules employed in executing RNAi strategies are short hairpin RNA (shRNA), small interfering RNA (siRNA) or endogenous microRNA, of which siRNA forms the major mode presently under clinical evaluation. siRNA molecules are easy to synthesize and do not need to be delivered into the nucleus as they do not require genome integration or the usage of DNA promoters. They act in a sequence-specific manner against a target messenger RNA (mRNA), which avoids unintended off-target effects. The RNA-induced silencing complex (RISC), which drives RNAi, protects siRNA from degradation by cytosolic nucleases thereby recycling the molecule for many rounds of cleavage activity against the target mRNA. This implies that even few siRNA molecules if delivered stably into the cell cytosol are sufficient to trigger long-lasting gene silencing.
In order to reach the desired organ/tissue and subsequently cross the cell membrane, these therapeutic siRNAs need to overcome several physiological barriers such as renal clearance, serum degradation and cell-specific uptake. Following crossing the cell membrane, intracellular barriers in the form of saturation of endogenous RNAi machinery or endosomal escape postendocytosis can reduce the efficiency of the delivered siRNA molecules. Small negatively charged siRNAs can also lead to immunotoxicity and over the past years efforts have been dedicated to develop an efficient carrier modalities to overcome these systemic barriers and toxicity issues, which broadly falls into viral and nonviral strategies. Due to safety concerns on usage of viral vectors, nonviral techniques have taken the center-stage in siRNAs delivery.
Delivery vehicles such as liposomes, lipid-based nanoparticles (LNPs) or polymeric nanoparticles are biodegradable, have relatively low toxicity, are stable in storage, easy-to scale up and have low production costs – traits favored from an industrial perspective. Moreover, most components used in the development of nanostructures in the form of lipids or polymers are approved by the regulatory agencies for human use. From a technical standpoint, delivering siRNAs in nanocarriers offers high encapsulation rate, potentially a controllable sustained release option or burst release and stability against degradation in the biological environment. In the case of cancer care, tumor physiology may aid in the accumulation of nanocarriers in the desired tissue or solid tumor via enhanced permeability and retention effect in the case of carcinoma but this needs to be tested on case-by-case studies and may not be an ultimate mechanism for all types of solid tumors.
Beginning with chemical modification of the siRNA molecules to stably sustain the harsh biological environment such as 2′o-Me or 2′o-Flu in specific sequences, much advancement has been achieved also by using various delivery vectors. Mostly classical cationic lipids (DOTAP, DOTMA) or cationic polymers (PEI, chitosan) have been used in formulations, conjugates or complexes to form lipoplexes or polyplexes. Exosomes are also being explored for gene delivery purposes. One of the most characterized platforms for siRNA delivery is the stable nucleic acid lipid particles (SNALPs), which represent approximately 70–120 nm nanocarriers. Many formulations under clinical investigations from Tekmira Pharmaceuticals and Alnylam Pharmaceuticals are formulated using SNALPs, which use ionizable lipids such as the DLin-DMA-based amino lipids as their prime component. A common feature of most carriers is PEGylation (coating of polyethylene glycol [PEG]), which provides both steric stability and protection from systemic uptake by macrophages and other types of leukocytes. Further modifying the nanocarrier surface with molecules that can impart/enhance functional activity are for example the use of targeting moieties to endow these carriers' high selectivity toward cell surface receptors.
limit search to this category
Diagnostic and Imaging
Skeletal Disorders
Targeted Drug Delivery
Nucleic Acid Lipid Nanoparticles
Polymeric Nanoparticles
Other Formulations
Small Molecule Drugs
Other Payloads
Journal of Controlled Release
Development of Lipid Nanoparticle Formulations of siRNA for Hepatocyte Gene Silencing Following Subcutaneous Administration
Chen S, Tam YY, Lin PJ, Leung AK, Tam YK, Cullis PR
siRNA Nucleic Acid Lipid Nanoparticles Genetic Medicine
Recently developed lipid nanoparticle (LNP) formulations of siRNA have proven to be effective agents for hepatocyte gene silencing following intravenous administration with at least three LNP-siRNA formulations in clinical trials.
Microfluidic Assembly of Liposomes with Tunable Size and Coloading Capabilities
JR Hoffman, E Tasciotti, R Molinaro
Small Molecule Drugs Nucleic Acid Lipid Nanoparticles Oncology
Liposomes used for the delivery of pharmaceuticals have difficulties scaling up and reaching clinical translation as they suffer from batch-to-batch variability.
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Notre Dame is a prime example of how fires get people talking.
Like I keep saying God creates light and darkness for those same reasons exactly.
Since without the hate or fury and flare what happens to people?
Beloved, we are now children of God, and what we will be has not yet been revealed.
We know that when Christ appears, we will be like Him, for we will see Him as He is.
I still find it ironic how I posted that certain churches should burn for stealing from God and suddenly, Notre Dame caught fire.
Next Post I'll repeat it again up front for those who only pay attention to titles, Notre Dame = Not really dementia.


Published: April 1, 2015 at 01:39 p.m.
Updated: April 1, 2015 at 06:25 p.m.
CORAL GABLES, Fla. -- Miami wide receiver Phillip Dorsett is one of the fastest players in the draft, and he showed that again Wednesday at the Hurricanes' pro day, with unofficial clockings of 4.25 and 4.27 seconds in the 40.
Dorsett, who measured in at 5-foot-10 and 184 pounds, ran the 40 in an impressive 4.33 seconds at the combine, and he said Wednesday that even though he felt he had a good combine, "I knew then I would do all the drills on pro day."
Dorsett said a good start led to the great 40 time. His 4.33 time at the combine was the third-fastest, and 4.25 would have been the fastest at the combine.
NFL Media analyst Mike Mayock said he thinks Dorsett is a "borderline" first-round guy and also said Dorsett is his favorite UM prospect in this draft.
Dorsett said he has scheduled meetings with the Atlanta Falcons, Carolina Panthers and Miami Dolphins and that he had dinner Tuesday night with the New Orleans Saints. Dorsett said he has talked with former UM star wide receivers Andre Johnson and Santana Moss for advice, and he said the one thing he wants to show in his team visits is that "I am willing to learn, willing to work."
Dorsett's speed obviously means he can be a dangerous deep threat, but he said he has some things ne needs to work on. An example? "I didn't get pressed a lot," he said, noting that he needs to work on beating press coverage.
Dorsett and Florida State's Rashad Greene were the starting wide receivers at powerhouse Fort Lauderdale (Fla.) St. Thomas Aquinas High, and it's likely that both will be off the board by the end of the second round.
In addition to preparing for the draft, Dorsett is taking three classes this semester and is scheduled to graduate in May with a sociology degree.


This is just one way of doing it - using our mesh bags - there are many ways of going about cleaning a fleece.
1. SKIRT-Take raw fleece and lay it out on the floor. Take off the very dirty wool around the edge of the fleece and check the rest of the fleece for excess dirt and hay, and remove that. Turn the fleece over and remove any visible short cuts.
2. SEPARATE- Separate the fleece into smaller pieces, and bundle it up, trying to keep most of the cut ends facing in. Then put the bundles in mesh bags and close the bags with rubber bands.
Note: Some people like to pre-soak a fleece in cold water before washing. This helps to begin to loosen and dissolve the dirt. The presoak works great for uncoated fleeces with dirty tips and wool with red clay on it. Hot wash water will permanently set red clay stains; so the pre-soak can be very important. If you use pre-soak you must be very careful not to agitate the wool when you go to the next step (washing) that uses very hot water. Drastically changing the water temperature combined with agitation will lead to the wool felting; however going from hot water to cold is far worse than the other way round. Soak for 24 hours, then drain and go to the wash cycle.
3. WASH-Put HOT water in a large tub or washer, enough water so that when the wool is submerged it isn't too cramped. BEFORE putting the wool in, add enough soap to make the water feel slippery. You can use dishwashing detergent; you want to make sure that the soap is good for cutting grease. Add wool, make sure it is wet, but don't agitate it or mess with it more then you have to or the wool could felt. Always add the wool to the water, don't run water onto the wool, this could felt it also. Let the wool sit in the soapy water for around a half hour. Then take the wool out and gently squeeze out the water (if you are using a washer just put the washer on the spin only cycle, leaving the wool in, then take the wool out before adding the rinse or other wash water).
If you are working with a very muddy or oily fleece you may need to do two washes. The second wash would be the same as the first one, but you may not need as much soap.
4. RINSE-To rinse: put water that is not as hot as the first water was, but not cool either (you want to avoid sudden change in water temperature so the wool doesn't felt) in the tub or washer. Put the wool in for 30 or so minutes. If the water comes out very dirty or soapy you will need to do a second rinse, same as the first.
NOTE: If using the washer, at NO time should the washer be allowed to agitate—if it does, you will have felt!
5. DRY-After rinsing the wool, spin the water out using the spin only cycle on the washer. Take the wool out of the bag and lay it out on a towel to dry. If you don't want to use the washer to spin out the extra water, the wool will just take longer to dry.


Have you ever felt that the amount of time you spend on exercising is not enough? Is there a feeling of unhappiness that there is something missing since you are unable to lose your excess weight?
In addition, do you feel that following a strict diet which is usually supplementary to doing exercises, not showing any results? Well, then the best advice you are going to get is to hire a personal trainer.
A personal trainer is like your body guard. He or she will make sure you follow a schedule, do not skip on your work outs, give you a healthy diet and also help you achieve your goals. However, not everybody understands the need for a personal trainer. So, here are few reality checks that will make you reconsider your view while you follow your own exercise routine.
While a personal trainer can take one look at your work out plan and tell you the required changes, doing it on your own will mean only one thing – that you have to do double the amount of exercises to achieve the same goal.
It could also be that the exercises that you think are the best for you are actually not burning the necessary fat required to shape your muscles. In fact, the exercises may not even be beneficial beyond superficial. So, if you are serious about changing your life for the positive, then you have to be serious about the exercises to do. You can get some great workout ideas and exercise programs from http://www.6weekbody.com.au.
You may think that the everyday running around the park will help you shed weight and make you fitter. However, while this works, it is a slow process. Your personal trainer will tell you how much need to run and how much exercise is required.
It should not be the case that by both of these, and instead of feeling invigorated, you would end up feeling tired. The irony here is that a personal trainer will stop you right before you exert and exhaust your body.
It is best to consult an expert when you want to start dieting. However, though online-diet courses that available are a poor substitute and should be wary of trying it without health advice. An experienced and established personal trainer will keep changing your diet as you start training.
First, it would be about reducing your excess fat and then after you start doing heavy exercises, your personal trainer will include more protein oriented food in your diet plan. This is to ensure your body is able to deal with the intense workouts that your trainer has planned for you. You also need to count your calories to lose weight, creating a calorie deficit is essential if you want to lose more weight.
Another reason that you would feel exhausted instead of feeling energised after doing exercises is lack of sleep. When you sleep, your muscles get time to repair and your tired tissues also get enough rest. If you do not maintain a consistent sleep cycle of eight hours every day, then it is going to affect your body cycle.