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Diabetes News October 31st 2008
Repeat Dosing Data for Capsulin Phase II in type 2 diabetes presented at the EASD Conference in Rome
Diabetology Limited, announced results from the 10-day repeat-dosing of Capsulin™ oral insulin in patients with type 2 diabetes at the European Association for the Study of Diabetes (EASD) meeting in Rome (Diabetology)
Oral GLP-1 Study Presented at the EASD Conference in Rome
Results from a preclinical study on Axcess™ oral formulated GLP-1 analogues have been presented in a poster presentation during the European Association for the Study of Diabetes (EASD) meeting in Rome (Diabetology)
New diabetes rate up 90 percent in past decade
The rate of new cases of diabetes soared by about 90 percent in the United States in the past decade, fueled by growing obesity and sedentary lifestyles (Reuters)
Effects of pioglitazone? on major cardiovascular adverse events in high risk patients with type 2 diabetes
The PROactive study failed to show a significant benefit for pioglitazone compared with placebo in people who had type 2 diabetes as well as other evidence of cardiovascular disease. Despite a re-analysis of secondary endpoint data from this study, claims of this showing a significant benefit for pioglitazone appear unjustified (National Prescribing Centre, UK)
GAD Treatment and Insulin Secretion in Recent-Onset Type 1 Diabetes
GAD-alum may contribute to the preservation of residual insulin secretion in patients with recent-onset type 1 diabetes, although it did not change the insulin requirement ( NeJM )
Study Finds Preventative Diabetes Care Reduces Amputation Occurrence
The APMA study, conducted by an independent research firm, found that 25 percent of the 600 people surveyed who had suffered an amputation from diabetes said they should have seen a specialist – such as a podiatrist – sooner (Market Watch)
Drug may prevent diabetes in arthritis patients
The risk of developing diabetes is cut in half among rheumatoid arthritis patients who use hydroxychloroquine for treatment, according to research findings reported this week at the American College of Rheumatology Annual Scientific Meeting in San Francisco (MedlinePlus)
Growing Number of Consumers Trust Online Resources Over Other Media for Researching Drug Treatment Information
60 percent would sign up for enewsletters – 25 percent would join email groups (PharmaLive)
Amylin says Byetta outperformed Januvia in trial
Eli Lilly and Co and Amylin Pharmaceuticals Inc said on Tuesday that a trial of their diabetes drug Byetta, which was recently linked with six deaths from pancreatitis, reduced glucose levels more than a rival drug from Merck & Co (BD Diabetes)
Tests show 2-year benefits of Merck diabetes drug
Merck & Co's diabetes drug Januvia substantially improves blood sugar levels over two years of treatment when combined with the older drug metformin and is generally well tolerated, new data on Tuesday showed (BD Diabetes)
Phenomix and Forest Laboratories to Collaborate on Development and Commercialization of Dutogliptin in Diabetes
Laboratories, Inc. and Phenomix Corporation today announced that they have entered into a definitive collaboration agreement to develop and commercialize dutogliptin (PHX1149) in North America. Dutogliptin is Phenomix' proprietary orally administered, small molecule dipeptidyl-peptidase-4 (DPP-4) inhibitor currently undergoing Phase 3 clinical development in Type 2 diabetes mellitus (PharmaLive)
Lilly Announces Launch of Color Differentiation System for Humalog and Humulin U-100 Insulin Products in the United States
With color differentiation, the redesigned labeling can help patients, health care providers and pharmacists accurately identify the insulin that has been prescribed (PharmaLive)
FDA Approves Sanofi-Aventis Rapid-Acting Insulin Apidra(R) for Treatment of Children with Diabetes
Sanofi-aventis announced today that the U.S. Food and Drug Administration (FDA) approved Apidra® (insulin glulisine [rDNA origin] injection) to improve glycemic control in children (4 years and older) with diabetes mellitus (BioSpace)
Insulin Resistance and Obesity in Childhood
Several factors are implicated in the pathogenesis of obesity-related insulin resistance, such as increased free fatty acids and many hormones and cytokines released by adipose tissue (European Journal of Endocrinology)
The glycemic index of bread and biscuits is markedly reduced by the addition of a proprietary fiber
The fiber mix added to the flour used in the preparation of biscuits and bread markedly reduces their GI (NMCD)
Vitamin K Supplements Reduce Progression of Insulin Resistance in Older Men
Vitamin K supplementation for 36 months at doses attainable in the diet may reduce progression of insulin resistance in older men, according to the results of a randomized controlled trial (Medscape)
Inverse association reported between type 2 diabetes and high intake of certain foods
New study findings suggested that multiple food groups may collectively influence the risk for type 2 diabetes (Endocrine Today)
New Teaching Tools Foster Science and Diabetes Education in Native American Schools
The Diabetes Education in Tribal Schools', "Health is Life in Balance", K-12 curriculum will be launched by the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health, the Indian Health Service , the Centers for Disease Control and Prevention and eight tribal colleges and universities (NIH, USA)
Video Games Zap Kids' Diabetes Risk
Nutrition Experts Creating Video Games to Help Children Prevent Obesity and Type 2 Diabetes (WebMD)
BT helps its 8,000 people with diabetes to tackle growing problem for businesses
BT today launched a campaign to try to help thousands of its people avoid developing Type 2 diabetes or manage it better if already diagnosed – by changing their lifestyle (BT, UK)
Systematic review: Cardiovascular outcomes in trials of oral diabetes medications
The authors note that clinical trials of oral therapies for type 2 diabetes mellitus have largely focused on intermediate clinical outcomes, such as changes in HbA1c, serum lipids and blood pressure. Specific effects CV risks remain unclear but such outcomes have 'unequivocal clinical relevance'(National electronic Library for Medicines)
Beyond Glycemic Control: Managing Obesity and Cardiovascular Disease Risk for Patients With Type 2 Diabetes in the Primary Care Setting
With increasingly more individuals affected by diabetes, it is important for primary care clinicians to understand and effectively manage the comorbid conditions associated with this disease (PeerView inSight)
Expensive new diabetes drugs may not be worth the money
The annual cost of diabetes drugs in the USA have nearly doubled to $12.5 billion between 2001 and 2007, raising questions about whether this actually translates into improved care (PharmaTimes)
The Handbook for Vascular Risk Assessment, Risk Reduction and Risk Management
This handbook brings together in one place information on our current state of knowledge about vascular risk assessment, risk reduction and risk management. It has been designed to be comprehensive, giving an overview of the latest state of knowledge. 150-page PDF (National Screening Committee)
Annual Professional Conference 2009
Our flagship annual event for healthcare professionals working in the field of diabetes (Diabetes UK)
Glycemic Management of Type 2 Diabetes
How Tight Is Right and How to Get There (Archives of Internal Medicine)
Cardiovascular Outcomes in Trials of Oral Diabetes Medications
Meta-analysis suggested that, compared with other oral diabetes agents and placebo, metformin was moderately protective and rosiglitazone possibly harmful, but lack of power prohibited firmer conclusions (Archives of Internal Medicine)
National Trends in Treatment of Type 2 Diabetes Mellitus, 1994-2007
Increasingly complex and costly diabetes treatments are being applied to an increasing population. The magnitude of these rapid changes raises concerns about whether these more costly therapies will result in proportionately improved outcomes (Archives of Internal Medicine)
Diabetes drug costs soaring, top $12B last year
Americans with diabetes nearly doubled their spending on drugs for the disease in just six years, with the bill last year climbing to an eye-popping $12.5 billion (Associated Press)
Researchers uniting to fight diabetes and heart disease
Health research and you – Diabetes. 2-page PDF (Research Australia)
Is a Priming Dose of Insulin Necessary in a Low-Dose Insulin Protocol for the Treatment of Diabetic Ketoacidosis?
A priming dose in low-dose insulin therapy in patients with DKA is unnecessary if an adequate dose of regular insulin of 0.14 unit · kg body weight–1 · h–1 (about 10 units/h in a 70-kg patient) is given (Diabetes Care)
Prandial Insulin and the Systemic Appearance of Meal-Derived Glucose in People With Type 1 Diabetes
Intriguingly, in this issue of Diabetes Care, Pennant et al. (2) report that the rate of meal-derived glucose appearance in people with type 1 diabetes is unchanged by administration of prandial insulin 20 min before meal ingestion (Diabetes Care)
Dietary Energy Density Predicts the Risk of Incident Type 2 Diabetes
This is the first large population-based prospective study to report that an energy-dense diet may be associated with increased risk of development of diabetes, independent of baseline obesity (Diabetes Care)
Pioglitazone-related insulin sensitivity boost mediates reduced NEFA levels
The authors suggest that "long-term administration of pioglitazone may promote reduced NEFA levels in part by increasing adipose tissue sensitivity to the anti-lipolytic effects of insulin (Medwire)
The sweeter side of ACE2: Physiological evidence for a role in diabetes
In this review we will examine the role of the renin-angiotensin system in the physiopathology and treatment of diabetes and highlight the potential benefits of the ACE2/Ang-(1-7)/Mas receptor axis, focusing on recent data about ACE2 (PubMed)
Prevention of diabetes and cardiovascular disease in patients with impaired glucose tolerance
Rationale and design of the Nateglinide And Valsartan in Impaired Glucose Tolerance Outcomes Research Trial (PubMed)
Canadian Diabetes Association Awards
A list of the 5 awards announced on 24th October (Canadian Diabetes Association)
The European Medicines Agency recommends suspension of the marketing authorisation of Acomplia
Acomplia has been authorised in the EU since June 2006 as an adjunct to diet and exercise for the treatment of obese patients or overweight patients with associated risk factors (EMEA)
Sanofi's Acomplia looks doomed after EU suspension
The CHMP said the new data from "post-marketing experience and ongoing clinical trials indicated that serious psychiatric disorders may be more common than in the clinical trials used in the initial assessment of the medicine". (PharmaTimes)
Categories: News Pre-2012
Diabetes News October 24th 2008
Appropriate advancement of type 2 diabetes therapy
An editorial workgroup meeting consisting of a multidisciplinary panel of diabetes thought leaders recently convened to provide additional insight on these issues. Their recommendations and viewpoints are reported in this supplement (Current Clinical Practice)
Oramed Pharmaceuticals Launches Phase 1A Trials of its InsulinSuppository
An insulin suppository represents an important development in the treatmentof diabetes as it provides a painless alternative for effective insulin delivery (Oramed)
Novo taps stem cells in hunt for diabetes cure
The world leader in diabetes care said on Thursday it had launched a new collaboration to develop a treatment for type 1 diabetes by programing stem cells to turn into insulin-producing cells (Reuters)
Forest Laboratories, Inc.and Phenomix Corporation in $340 Million Diabetes Deal
Announcing that they have entered into a definitive collaboration agreement to develop and commercialize dutogliptin (BioSpace)
This article is the 8th in a 12-part series reviewing the fundamentals of diabetes care for physicians in training (Clinical Diabetes)
Tougher diabetes targets will 'neglect highest risk patients'
The decision to toughen up the QOF diabetes targets has sparked a row between experts amid claims that GPs will be forced to 'concentrate their efforts in the wrong place' (Pulse, UK)
Physical Activity May Facilitate Diabetes Prevention in Adolescents
These results suggest that moderate activity may be beneficial in the prevention of diabetes in adolescent populations both through promoting efficient glucose disposal and through increasing energy expenditure (Diabetes Care)
American Diabetes Association, European Association for the Study of Diabetes Publish Consensus Algorithm for Type 2 Diabetes Treatment
The revisions to the diabetes treatment algorithm, first published in 2006, provide guidance to health care providers for treating type 2 diabetes, taking into account new medications that have come on the market and the most current scientific data regarding previously recommended drugs (Market Watch)
Novel Insulin Formulation Provides for Glucose-regulated Insulin Delivery
SmartCells, Inc. and Juvenile Diabetes Research Foundation Announce Partnership and $1 Million Funding to Advance SmartInsulin(TM) for Type 1 Diabetes (Market Watch)
Seattle, Swedish researchers working on diabetes vaccine
Video – Are we close to preventing Type 1 diabetes? A vaccine may not be far off. Researchers from Sweden are in Seattle this weekend to announce their findings on a promising new study (King5, USA)
Thiazolidinediones are partial agonists for the Glucocorticoid Receptor
Both Ciglitazone and Pioglitazone, structurally related to Rosiglitazone, show similar effects on the Glucocorticoid Receptor (Endocrinology)
Aussies to flock to NZ for diabetes trial
Hundreds of Australians with Type 1 diabetes are trying to join a clinical trial in New Zealand which will see human patients injected with pig cells (ABC, Australia)
Year of Care Practical Guide
The Year of Care programme, a joint venture supported by Diabetes UK, NHS National Diabetes Support Team, Department of Health and the Health Foundation, has published "Getting to Grips with the Year of Care: A Practical Guide" 47-page PDF (NDST)
Management of cardiovascular disease in patients with diabetes: the 2008 Canadian Diabetes Association guidelines
Because cardiovascular disease is the main cause of mortality among diabetic patients, managing cardiovascular risk should be a key treatment goal for providers and patients (Canadian Medical Association)
Diabetes mellitus, exocrine pancreatic deficiency, hypertrichosis, hyperpigmentation, and chronic inflammation: confirmation of a syndrome
The presence of consanguinity in the parents and similarity of clinical features in the siblings are suggestive of a novel autoimmune disorder, possibly secondary to autosomal recessive inheritance (Pediatric Diabetes)
New Zealand to transplant pig cells into humans against diabetes
New Zealand has given the go-ahead to a controversial clinical trial involving the transplantation of insulin-producing pig cells into humans to treat type-1 diabetes (Telegraph, UK)
Boehringer in type-two diabetes drug development
The company has unveiled a pipeline of novel oral antidiabetic compounds which are at the phase-two and phase-three stage of clinical testing (HAYS Pharma)
Amylin Gets $125M from Eli Lilly To Make Once-Weekly Diabetes Drug
Amylin Pharmaceuticals said today it has scored a $125 million cash payment from Eli Lilly to manufacture a once-weekly injectable version of exenatide for diabetes (Xconomy)
Diabetes growth doubles in a year
The number of people diagnosed with diabetes in the UK has risen by more than 167,000 since last year, bringing the total diabetes population to almost 2.5 million according to new data from GP practices (Diabetes UK)
New Guidelines set to help improve services for adults with diabetes
Health Minister Edwina Hart has today unveiled new guidelines that form part of a delivery strategy for the management of adults with diabetes in Wales (Welsh Assembly Government, UK)
Screening for type 2 diabetes: A randomised controlled trial in British general practice
Screening for type 2 diabetes in primary care is feasible but may be associated with higher levels of short-term anxiety among invited compared with non-invited participants (BMC Public Health)
Surgery offers best diabetes care in the country
The practice has received an award from Health Secretary Alan Johnson after scoring the highest marks nationally for its service (Salisbury Journal, UK)
Improved survival in both men and women with diabetes between 1980 and 2004 – a cohort study in Sweden
Survival rates have improved in subjects with diabetes since the early 1980s, more so in women than in men, thereby decreasing the gap to non-diabetic women (Cardiovascular Diabetology )
Relationship between beta-cell mass and diabetes onset
The relative contribution of beta-cell loss versus beta-cell dysfunction to diabetes onset remains an area of controversy. However, because cytotoxicity sufficient to induce beta-cell apoptosis predictably disturbs beta-cell function, it is naive to attempt to distinguish the relative contributions of these linked processes to diabetes onset (PubMed)
High levels of adiponectin reduce the risk of type 2 diabetes in women
Elevated concentrations of total and high-molecular-weight adiponectin inversely and strongly correlated with a substantially reduced risk for diabetes (American Diabetes Association)
Daily drug helps diabetes patients
Patients given a daily dose of liraglutide, a human GLP-1 analogue, achieved better blood glucose control than those treated with exenatide, a GLP-1 mimetic administered twice daily (Pharmacy Europe)
Aspirin or antioxidants of no benefit in primary prevention of cardiovascular events and mortality in diabetic patients
Findings from the POPADAD (prevention of progression of arterial disease and diabetes) study have been published early online in the BMJ (National elctronic Library for Medicines, NHS, UK)
Aspirin use in people with diabetes
Behind the headlines (NHS Choices)
Effect of metformin in patients with type-1 diabetes and persistent inadequate glycaemic control
The researchers conclude that though adjunct metformin did not improve glycaemic control in patients with poorly controlled type 1 diabetes, it was linked to reductions of insulin dose and body weight (National elctronic Library for Medicines, NHS, UK)
Effectiveness of continuous glucose monitoring in pregnant women with diabetes: randomised clinical trial
Continuous glucose monitoring during pregnancy is associated with improved glycaemic control in the third trimester, lower birth weight, and reduced risk of macrosomia (BMJ, UK)
Commentary: The technology of continuous glucose monitoring
Continuous glucose monitoring "fleshes out" the information obtained from conventional self monitored glucose readings, helping inform changes to management and providing a graphic educational tool (BMJ, UK)
Obesity in children. Part 1: Epidemiology, measurement, risk factors, and screening
Modifiable risk factors for childhood obesity are maternal gestational diabetes; high levels of television viewing; low levels of physical activity; parents' inactivity; and high consumption of dietary fat, carbohydrate, and sweetened drinks (BMJ, UK)
Warning as Welsh diabetes figures grow by 10,000
Dai Williams, Diabetes UK Cymru's national director, said: "There is no getting away from the fact that the growth of diabetes is linked to the obesity crisis (Wales Online, UK)
Are the adverse effects of glitazones linked to induced testosterone deficiency?
This hypothesis explains the adverse effects of glitazones on the heart and other organs by reducing androgen action in directing stem cells differentiation into myocytes, vascular endothelium, erythroid stem cells and osteoblasts, and promoting adipocyte differentiation (Cardiovascular Diabetology)
Recent and emerging anti-diabetes targets
A panel of 20 emerging diabetes targets is presented, and small molecule modulators for each target will be discussed (Medicinal Research Reviews)
Effects of a telephone intervention in patients with type 2 diabetes
These results demonstrate that a telephone intervention can increase physical activity and reduce cardiovascular risk factors. As a result it may reduce health care-related costs (PubMed)
2008 Type 2 Update report
On current trends by 2022 the total number of people with Type 2 diabetes is expected to be at least 407,000. This is more than 150,000 (60%) above the prediction based on the 2001 prevalence. Forecast levels are increasing all the time because actual experience is proving to be well above forecasts (Diabetes New Zealand)
Recent guidelines recommend rapid advancement of antiglycemic therapy, with early initiation of insulin as a practical and effective option, but they offer little guidance for primary care physicians with respect to the practical implementation and inclusion of either basal or rapid-acting analogs into treatment regimens.These guidelines also do not adequately address the therapeutic role of some newer agents (eg, the incretin group). An editorial workgroup meeting consisting of a multidisciplinary panel of diabetes thought leaders recently convened to provide additional insight on these issues. Their recommendations and viewpoints are reported in this supplement (Current Clinical Practice)
Generex Announces Enrollment of Initial Subjects in Metformin Gum Trial
The protocol for the study is an open-label, two-treatment, two-period, randomized, crossover study comparing MetControl™ and immediate release Metformin tablets in healthy volunteers (Generex Biotechnology Corporation, USA)
Joslin receives $3 Million to study obesity
Joslin Diabetes Center has received a three-year, $3 million grant from the Eli Lilly and Company Foundation to help fund studies that will investigate the underlying causes of obesity and insulin resistance (Renal Business Today)
Beta-cell function improved with R-1583, a novel long-acting GLP-1 analogue
Researchers at Roche have reported phase II results from an 8-week, double-blind, placebo-controlled study evaluating taspoglutide (R-1583), a glucagon-like peptide-1 (GLP-1) receptor agonist, in type 2 diabetes patients inadequately controlled with metformin (American Diabetes Association)
Glutamic acid decarboxylase may help to preserve residual insulin secretion
Treatment with alum-formulated glutamic acid decarboxylase contributed to the preservation of residual insulin secretion in patients with recent-onset type 1 diabetes, but did not change the insulin requirement in a recent study (Endocrine Today)
Novo Nordisk Assigns Inhaled Insulin Patent Portfolio to Aradigm
Aradigm Corporation, a specialty pharmaceutical company, announced that Novo Nordisk transferred to Aradigm, at no charge, a portfolio of inhaled insulin related patents pursuant to a license agreement between Aradigm and Novo that was terminated in May 2008 (PharmaLive)
Putting the NICE Guideline on Type 2 Diabetes into Practice
In this article, we will focus on the important areas of patient education, dietary assessment, setting targets for HbA1c, self-monitoring and starting insulin therapy. 4-page PDF (British Journal of Primary Care Nursing)
Why do People with Diabetes Fall Off the Rails?
This article reviews what I found and offers some suggestions on how to help patients get back in control. 3-page PDF (British Journal of Primary Care Nursing)
Tackling Type 2 diabetes prevention
Diabetes UK held its first Frontiers in Diabetes meeting this week. The event looked at generating practical strategies for the prevention of Type 2 diabetes in the UK (Diabetes UK)
GPs in Scotland have wider type-2 diabetes treatment choice
GPs in Scotland now have a wider choice of treatments for type-2 diabetes following acceptance of the dipeptidyl peptidase 4 (DPP-4) inhibitor sitagliptin by the Scottish Medicines Consortium (Healthcare Republic)
Obesity Upregulates Genes Involved in Oxidative Phosphorylation in Livers of Diabetic Patients
Obesity may affect the pathophysiology of type 2 diabetes by upregulating genes involved in OXPHOS in association with insulin resistance markers and the expression of genes involved in hepatic gluconeogenesis and ROS generation (Obesity)
Clinical resolution of glycogenic hepatopathy following improved glycemic control
Glycogenic hepatopathy is an underrecognized complication of long-standing poorly controlled diabetes mellitus … It is important to distinguish this entity as it has the potential for resolution following improved glycemic control as described by this case report (Journal of Diabetes and its Complications)
Telmisartan may be potential treatment for high-risk diabetes, vascular disease
Patients with vascular disease or high-risk diabetes who are unable to tolerate ACE inhibitors may have reduced cardiovascular death, myocardial infarction or stroke with telmisartan treatment (Endocrine today)
The Incidence of Tinea Pedis in Diabetic versus Nondiabetic Patients with Interdigital Macerations
The prevalence in the nondiabetic group was 37.5% and 42.5% for the diabetic group. This was not a statistically significant difference (Journal of the American Podiatric Medical Association)
Live interactive webcast: Insulin pump therapy
Watch and participate in interviews and discussions with healthcare professionals, hear pumpers share their experiences and get views from support groups and one of the UK's leading diabetes charities. 13th November 2008, 7.30pm – 8.30pm (diabetesLive)
DIAMAP
The mission of DIAMAP is to undertake a wide survey of the current European diabetes research landscape from which expert opinion can identify gaps and highlight strengths, to guide a Road Map strategy for diabetes in Europe (DIAMAP)
PPD contracted for juvenile diabetes research
US-based contract research organisation PPD has been selected as a full-service preferred provider for translational clinical development services by the Juvenile Diabetes Research Foundation (PharmaTimes)
Weight gain in early life predicts risk of islet autoimmunity in children with a first degree relative with type 1 diabetes
In a prospective birth cohort study we followed infants, who had a first-degree relative with type 1 diabetes, to investigate the relationship between early growth and infant feeding, and the risk of islet autoimmunity (Diabetes Care)
Impaired Vision Twice As Common in Diabetics
Vision loss is nearly twice as common among U.S. adults with diabetes as those without diabetes, according to research published today (American Diabetes Association)
International Diabetes Federation calls for global action to keep all children with diabetes alive
The International Diabetes Federation announced today that it is bringing together key opinion leaders to push for action to secure care for the thousands of children with diabetes in developing countries without access (IDF)
Levels Of Key Hormone During First Trimester Of Pregnancy Could Lead To Earlier Diagnosis Of Gestational Diabetes
New research shows women who develop diabetes during pregnancy (gestational diabetes mellitus) have reduced levels of an insulin-sensitive hormone, adiponectin, as early as nine weeks into the pregnancy (National Diabetes Support Team)
Diabetes screening brings huge cut in CVD risk
Screening for diabetes and treating newly identified cases can have a dramatic effect at reducing cardiovascular risk, new research concludes (PULSE)
FDA review of Takeda's alogliptin will not be finished on time
Takeda Pharmaceutical Co is going to have to wait a bit longer to market alogliptin after US regulators said they need more time to evaluate the Japanese drugmaker's experimental type 2 diabetes drug (PharmaTimes)
Sector Snap: Diabetes drug developers gain ground
A regulatory delay for Takeda Pharmaceuticals developing diabetes drug alogliptin helped boost shares of competitor Merck & Co. Monday, highlighting the competitive nature of diabetes drug development within the pharmaceutical and biotech sectors (Business Week)
Low Testosterone a Problem in Young Diabetic Men
About one third of young adult men with type 2 diabetes have low testosterone levels, research shows. (American Diabetes Association)
High prevalence of vitamin D deficiency in type 1 diabetes mellitus and healthy children
Epidemiological studies suggest a link between vitamin D deficiency in early life and the later onset of type 1 diabetes. (PubMed)
Parkinson's disease was not a risk factor for diabetes
The prevalence of diabetes was similar — albeit slightly lower — among patients with Parkinson's disease compared with patients without the disease, (Endocrine Today)
Teens' Faculties Not Harmed by Low Blood Sugar
Teenagers with type 1 diabetes who aim to keep their glucose levels under tight control may have frequent episodes of too-low blood sugar, but this apparently has no lasting effect on their cognitive function (American Diabetes Association)
Targeting Blood Glucose Management in School Improves Glycemic Control in Children with Poorly Controlled Type 1 Diabetes Mellitus
Average HbA1c was lowered by 1.6%, suggesting that this intervention helps this difficult group of patients (Clinical and Laboratory Observation)
In Vivo Insulin Sensitivity and Secretion in Obese Youth: What are the Differences between NGT, IGT and Type 2 Diabetes?
Data suggest that measures to prevent progression or conversion from pre-diabetes to T2DM should target improvement in beta-cell function (PubMed)
Diabetes costs NHS £1 million per hour
A report published by Diabetes UK confirms that diabetes is one of the biggest health challenges facing the UK (Diabetes UK)
HbA1c of at least 6.1% can identify patients with undiagnosed diabetes
At-risk individuals with an HbA1c test level >=6.1% are more likely to have undiagnosed diabetes, according to new study findings (Endocrine Today)
The Darkening Cloud of Diabetes: Do Trends in Cardiovascular Risk Management Provide a Silver Lining?
During our period of study, there was an increase in the utilization of evidenced based drug therapies in people with diabetes and reductions in cardiovascular-related hospitalizations. Despite this, we observed no change in all-cause mortality (Diabetes Care)
The autumn edition of the Update magazine is now available for download (Diabetes UK)
International tables of glycemic index and glycemic load values: 2008
The tables list the GI of over 2,480 individual food items (Diabetes care)
The Crosstalk Between Insulin and Renin-Angiotensin-Aldosterone Signaling Systems and its Effect on Glucose Metabolism and Diabetes Prevention
This review will discuss: a) the molecular mechanisms of the crosstalk between the insulin and angiotensin II signaling systems b) the results of clinical studies employing drugs targeting the renin-angiotensin IIaldosterone systems and their role in glucose metabolism and diabetes prevention (Current Vascular Pharmacology)
Follow up analysis of genome-wide association data identifies novel loci for type 1 diabetes
Evaluation of a large number of statistical GWA candidates in several independent cohorts has revealed additional loci that are associated with T1D (Diabetes)
The clinical relevance of assessing advanced glycation endproducts accumulation in diabetes
This review article will focus on the clinical relevance of measuring advanced glycation endproducts (AGE) accumulation in diabetic patients by focusing on AGE formation, AGEs as predictors of long-term complications, and interventions against AGEs (Cardiovascular Diabetology)
Effect of weight-reducing agents on glycaemic parameters and progression to Type 2 diabetes: a review
This review summarizes evidence from 23 placebo-controlled randomized trials, of at least 1 year duration, on the effects of drugs promoting weight loss (orlistat, sibutramine and rimonabant) on glycaemic variables, diabetes incidence and diabetes control (Diabetic Medicine)
Cost of obesity to local health services revealed
New figures out today show, for the first time, the cost of obesity to every Primary Care Trust in England (NHS, UK)
Islet Specific Wnt Activation in Human Type 2 Diabetes
Large PDF download available (Experimental Diabetes Research)
Beware the silent assassin – Diabetes UK launches hard-hitting ad campaign
The advertising campaign, developed by The Gate, will include a series of outdoor posters as well as newspaper and consumer magazine advertising during October and November 2008 (Diabetes UK)
CD28/CD154 Blockade Prevents Autoimmune Diabetes by Inducing Nondeletional Tolerance After Effector T-Cell Inhibition and Regulatory T-Cell Expansion
Immunotherapies that selectively suppress effector T-cells while permitting the development of natural regulatory mechanisms may have a unique role in establishing targeted long-standing immune protection and peripheral tolerance (Diabetes)
Postpartum Screening for Diabetes After a Gestational Diabetes Mellitus–Affected Pregnancy
Postpartum glucose testing in women with GDM-affected pregnancies increased over time. However, even in recent years, 42% of women with GDM-affected pregnancies failed to have a postpartum FPG test, and no test was ordered for 21% of GDM-affected pregnancies (Obstetrics & Gynecology)
Prevalence of abnormal glucose metabolism in atrial fibrillation: a case control study in 75-year old subjects
Atrial fibrillation is associated with chronic hyperglycaemia amongst 75-year old subjects. Prediabetes and DM should be pro-actively assessed if AF duration >= 5 years (Cardiovascular Diabetology)
VIVUS Announces the Weight Loss Effects of Qnexa in Type 2 Diabetes
Presentation at the Obesity Society Annual Scientific Meeting Shows Weight Loss of 17 Pounds in 28 Weeks (MarketWatch)
A diet pill? Put it down to fat chance
A collaboration between six Melbourne institutions could result in a pill that eliminates obesity and diabetes (The Age, Australia)
iSense and Their "Glycemic Signature"
What's new and different with the iSense system versus the current CGM models that have recently hit the market are two things: the special flexible micro-wire technology of their sensor, and the sophisticated data reporting system they're developing, which they call The Glycemic Signature (Diabetes mine)
The relationship between fasting hyperglycemia and insulin secretion in subjects with normal or impaired glucose tolerance
Small increments in FPG, within the "normal" range, are associated with a marked decline in glucose-stimulated insulin secretion and the decrease in insulin secretion with increasing FPG is greater in subjects with NGT than IGT and primarily is due to a decline in early-phase insulin secretion (PubMed)
Fasting insulin is a stronger cardiovascular risk factor in women than in men
In parallel with diabetes, fasting hyperinsulinaemia reflecting insulin resistance in non-diabetic subjects is associated with an increased risk for cardiovascular disease, which is more pronounced in women than in men (PubMed)
Diabetes UK backs National Diabetes Audit in Wales
Diabetes UK Cymru is encouraging GPs' surgeries to follow the example of paediatric centres in Wales and take part in the National Diabetes Audit (Diabetes UK)
Diabetes Forecast Takes a Look Back and a Step Forward
For 60 years, Diabetes Forecast, the consumer magazine of the American Diabetes Association (ADA), has been bringing crucial information to people with diabetes. The October issue celebrates the magazine's 60th anniversary with a major redesign that takes on a more contemporary look and includes new features on research, nutrition, and treatment (Market Watch)
F as in Fat
How obesity policies are failing in America. 144-page PDF (The Trust for America's Health)
Improving treatment for those with both diabetes and mental health
With those who have a mental illness more likely to have type-2 diabetes, health workers across SA are meeting to discuss improving treatment and prevention (Department of Health, Australia)
Pattern of 24-hour ambulatory blood pressure monitoring in type 2 diabetic patients with cardiovascular dysautonomy
Type 2 diabetic patients with more severe CAN have higher SBP and PP, especially during the nighttime and early morning, as well as a higher prevalence of nondipping status (PubMed)
Exenatide once weekly versus twice daily for the treatment of type 2 diabetes
A randomised, open-label, non-inferiority study (The Lancet, UK)
Dr Reddy's diabetes drug may be delayed
Rheoscience A/S, the Danish firm conducting phase III clinical trials on Balaglitazone, has run into a financial crisis (Live Mint. Wall Street Journal, USA)
Is diabetes education truly profitable?
Yes, but educators must explore other money-making opportunities – Yes, but educators must think like a business, act like a business (Endocrine Today, USA)
Diabetes News October 3rd 2008
Metformin May Help Delay or Prevent Diabetes in Women Who Had Gestational Diabetes
In the current study, intensive lifestyle and metformin reduced the risk for incident diabetes to a similar degree among women with a history of GDM, but metformin was less effective than lifestyle change among women who did not have a history of GDM (Medscape)
Insulin Analogs May Improve Quality of Life
Insulin regimens that use a fast-acting analog may be more convenient than regimens using regular insulin and may help patients better control their diabetes and enjoy a higher quality of life (American Diabetes Association)
Depression linked to higher death rates from all causes among elderly with diabetes
2-year study looked at more than 10,000 Medicare beneficiaries with diabetes (EurekAlert)
Obese people could get cash to make them see a GP
Unhealthy people could be offered financial incentives to go and see a doctor (Telegraph, UK)
Medicare rebates only a small step in the fight against obesity
Professor Kerry Mummery acknowledges the burden that obesity is currently placing on individuals and on the health care system, but calls for more support in prevention, rather than treatment programs (AHHA, Australia)
Euro Consumer Diabetes Index 2008
The Euro Consumer Diabetes Index provides the first ranking of European diabetes healthcare services across five key areas: Information, Consumer Rights and Choice; Generosity, Prevention; Access to Procedures and Outcomes. 55-page PDF (Health Consumer Powerhouse)
If you have diabetes, go to Denmark!
Denmark is the overall winner in the Euro Consumer Diabetes Index 2008, launched today in Brussels during a press conference hosted by the (Health Consumer Powerhouse)
First patients to test diabetes vaccine
The Swedish company Diamyd Medical declares that the first ten per cent in a phase III study of Diamyd diabetes vaccine are screened (Biotech Scandinavia)
More exercise needed to tackle child obesity
To maintain good health and stave off obesity and other serious illness in later life, it is recommended that children engage in at least 60 minutes of moderate to vigorous physical activity every day (BMA, UK)
Backpacker with diabetes launches Diabetes UK into world of blogs
Josh, in his early twenties with Type 1 diabetes, is travelling the Trans Siberian Express, via St Petersburg (Pictured), on to Thailand and beyond. He will be giving us regular accounts of his travels and how he has managed his diabetes whilst travelling (Diabetes UK)
Pfizer alters focus in rush for new drugs
Pfizer Inc. will abandon early stage research on heart drugs as part of a strategy to sharpen its focus on ailments such as cancer, Alzheimer's disease, and diabetes where the chances of a bigger profit are greatest (Boston Globe, USA)
Focus on the World Diabetes Diagnostics Market
This report analyzes the worldwide markets for Diabetes Diagnostics in Millions of US$ (Market Watch)
Vessel Shrinkage as a Sign of Atherosclerosis Progression in Type 2 Diabetes Mellitus: A Serial Intravascular Ultrasound Analysis
This serial IVUS study suggests that progression of coronary artery disease in patients with type II diabetes mellitus may be mainly attributed to vessel shrinkage (Diabetes)
Interim results for a novel DNA plasmid BHT-3021 from a phase I/II type 1 diabetes study
Bayhill Therapeutics is currently conducting a phase I/II study to evaluate safety and efficacy of its novel antigen-specific plasmid encoding human insulin BHT-3021 in type 1 diabetes (American Diabetes Association)
GI News
October 2008 edition (GI News, Australia)
High Protein Diets- Do They Work??
Study reveals that one significant contributing factor to keeping weight off is regular contact with health professionals (Diabetes In Control)
Help shine a light on diabetes
Diabetes UK is encouraging people across the country to light local monuments in blue on 14 November to mark World Diabetes Day (Diabetes UK)
Risk Prediction of Cardiovascular Disease in Type 2 Diabetes
This more simplified risk equation enables 5-year risk prediction of CVD based on easily available nonlaboratory predictors in clinical practice (Diabetes Care)
Glucose metabolism higher among women with surgical menopause
Women who underwent surgical menopause had higher BMI, HbA1c levels and two-hour blood glucose levels compared with those who had natural menopause in a study presented at the North American Menopause Society 19th Annual Scientific Meeting (Endocrine Today)
The California Diabetes Program Has Been Saved!
Late on Monday the California Diabetes Program received official notice that their request for exemption from the Governor's Executive Order was approved! (Diabetes Health)


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Dr. Dean Toriumi' s consultations at the facial Plastic Surgery Center include the use of a 3-D imaging system; with this patients can work directly with Dr. Toriumi to see options for and choose their desired results before surgery is performed. Dr. Toriumi has been practicing over 20 years. His expertise, attention to detail and experience are key to his patients receiving the very best outcomes.
The Facial Plastic Surgery Center is dedicated solely to care of the face. We not only offer facial plastic surgery but also non-surgical facial procedures, injectables and facial and skin care products. Our professional aesthetician offers treatments, such as microdermabrasion and superficial chemical peels, to complement your cosmetic facial surgery.
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text:
[Parenting] Happiness is up to you.
On 2017년 June 16일
Photo Source: Pixar Bay
Happiness exists in many ways in many places. Even if you are single, you can still be happy and no one can take away your happiness.
Many people misunderstand the life of a single. People think there is something wrong with them.
People misunderstand that a single is not enough to be loved by someone. Sometimes people are constantly criticized until they acknowledge their faults.
Gabriela Herstik, a Latin cultural writer for HelloGIggles, teaches how to love herself.
Herstick initially thought he had something wrong with him. But she filled her with what she wanted and taught her how to love herself.
Passion, resentment, and boldness also discouraged her because she had a bad influence on love between men and women.
But then she found out that she had to accept all of this as herself.
"The first thing my mother taught me is that in order to love someone else, I have to love myself," Herstogic said.
There are many kinds of love in the world. Romantic love is just one of them. Herstick found a more special love from her twin sister.
Her best friend, Sister, supported and encouraged her. This relationship helped her grow. Herstic stressed, "Find people who understand you."
"It is a journey that is not a destination, but accepting mistakes and imperfection, and realizing that you are not perfect, is the beginning of your journey to love yourself," she said.
Like Herstick, we have to grow. Since life is ours rather than standards established by society, we must do our own happiness.
Becka Martin, author of the Thought Catalog, said, "Live the life of your own value, not the old life guideline you want."

redpajama_set_name: RedPajamaCommonCrawl


It occurred to me the other day, that shortbread and all those shortbread-a-like biscuits that have that flaky short crumb are basically just shortcrust pastry with sweetener and maybe flavourings..
And now I had mastered shortcrust pastry, I could probably master yummy biscuits too.
So, as it is Christmas, and as shortbread is a family tradition (My Granny's was legendary) I thought I had better make some immediately, if not sooner.
The fat I used in place of butter is coconut oil. It has a slightly lower melting temperature than butter, but in our cold climate it stays solid out of the fridge. For my warm climate readers, keep it in the fridge for best results. You need it solid to create that lovely crisp flaky texture.
If you use unrefined coconut oil these will taste a little *coconutty* however you could try a gently refined oil if you want to remove that flavour. All my testers however have loved it with a slight coconut flavour, so I'll keep making them with my unrefined oil.
A few frozen cubes of aquafaba (the juice from the tin of chickpeas!) replaces eggs and then you can flavour these as you like.
These gorgeous cookies are much easier to roll out and stamp into cute shapes if you leave the dough in the fridge for an hour or so. When I'm ready to bake, I break off just as much as I can roll out on my surface and leave the rest in the fridge . Make sure your surface is dry and generously sprinkled with flour!!
Add flavourings if you wish, or just serve simply with sugar on top.
These fab little biscuits are the perfect gift to take along to treat a friend who is hosting a Christmas party!
This easy vegan recipe is the perfect alternative to traditional shortbread cookies. Easy to roll out and decorate, and even easier to eat!
You will end up with a fine crumb texture.
Drop by drop add the water until the dough starts to come together.
Take the dough out of the food processor & gently press together so it becomes a ball. Keep the lightest touch and don't overheat the dough! Pop it into the fridge for 10mins-1/2 an hour to cool.
Break of around 1/3 of the dough & roll out onto a dry floured surface : approx 5-8mm thick.
Stamp out into stars (or whatever you choose!) and put them onto a baking sheet lined with baking paper. Work quickly, you want to keep the dough cool to keep that crisp, flaky texture.
Bake for around 10 minutes on the middle shelf.
Repeat with the rest of the dough!
You can decorate these with icing or melted chocolate if you're creative!
The key to all shortbread is to keep it cool and don't overwork it! Keep dough you're not working with in the fridge and make sure you don't put cold dough onto a hot tray.