Twelve students and four professors traveled to Poland to attend the 2013 World Summit of Nobel Peace Prize Laureates on Oct. 19 through Oct. 26 with the Albert Schweitzer Institute.
The students arrived in Warsaw, Poland and were given a tour of the city where they visited museums and learned about the history of Poland. For the following three days they attended the conference with 150 other students from all over the world.
During the conference they got to hear from different Nobel Peace Prize laureates and leaders of nonprofit organizations. They talked about issues such as social justice, human rights, peace building and national security.
Dr. Albert Schweitzer, whom the Quinnipiac institute is named after, was a Nobel Peace Prize Laureate in 1952. The Executive Director of the Albert Schweitzer Institute, David Ives, has become a large part of the summits for the past nine years as part of the corporate committee that runs the event.
He took students when the Summit was in Berlin, Chicago, Hiroshima and now this past Summit in Warsaw.
"The faculty, staff and students that have been on this trip say that the experience is constantly in their minds," Ives said.
Quinnipiac alumnus Louis Venturelli went on the trip to Hiroshima and now works with organizing the student-centered part of the conference.
After attending the conference, the students traveled to Kraków, Poland where professor of communications Ewa Callahan gave them a tour. The following day the students went to Auschwitz, a concentration camp built and operated by Nazi Germany during World War II.
For many students, this was the most memorable part of the trip and Ives said when the students arrived they were quiet, observant and extremely moved.
"It was a very interesting, somber, but also beneficial experience for all of us students to learn about what actually went on there and walk the grounds of Auschwitz where millions of people died, and to never forget the history that happened there," Alex Soucy, a fifth year MBA student and program student leader, said.
Senior broadcast journalism major Raye-Lani Nyhuis said going to Auschwitz put everything in perspective for her. She says it summed up everything she learned at the conference and made her realize the efforts that people put in to make sure the world is peaceful.
"It kind of makes me want to go the extra mile to stop things from happening," Nyhuis said.
The trip as a whole was an eye opening opportunity for the students, according to Ives.
He said he met a girl a couple of years ago at the Summit from Hiroshima who was says the summit changed her life because it gave her connections from outside of Japan and now she is working for international social businesses.
Networking with students from around the world was another important aspect to the trip.
"I think the most impactful part of the trip was definitely meeting students from all over the world and learning about their lives, and the non profit organizations that they are a part of or the peace building efforts they are a part of," Soucy said.
Fifth year MBA student Anthony Allen encourages students to travel and accept abroad opportunities.
One of the student leaders on the trip Kelly Lavallee was greatly impacted from the trip, especially after hearing Nobel Peace Prize recipient Muhammad Yunis speak. Yunis gave out one loan to help one person in Bangladesh, and sparked the global microcredit movement which eliminated 50 percent of the nation's poverty.


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Auctioned revolver nets nearly $1M. Previous owner: Theodore Roosevelt
A Smith & Wesson revolver belonging to former President Theodore Roosevelt fetched a handsome price when the brisk chant of the Rock Island Auction Company's auctioneer finally came to an oxygen-saving conclusion.
The weapon, which netted a staggering $910,625 by the time the auctioneer's gavel signaled the final bid, is a .38 Long Colt-chambered No. 3 single-action revolver that was presented to then-Col. Roosevelt on May 12, 1898, a day that coincides with his departure for San Antonio to train with the Rough Riders for eventual combat against Spanish forces in Cuba.
"Firearms with presidential ties are highly sought after and extremely difficult to find," Kevin Hogan, Rock Island Auction Company president, said at the time of the sale. "Being tied to such an important office frequently places these arms at historic moments in American history. We've had the responsibility of offering three presidential arms in 2022, which is unheard of, but it never ceases to be something special."
It's likely Roosevelt intended for the weapon to be carried into war against Spain, according to documentation compiled by Rock Island. Instead, the Bull Moose carried a Colt Model 1892 double-action revolver that was recovered from the wreckage of the USS Maine, which, following an accidental explosion, sank in 1898 in the Havana Harbor. Despite the nature of the ship's demise, national hysteria and calls for war with Spain ensued.
The 1898 Roosevelt revolver. (Rock Island)
After the Spanish-American war, the eventual president held on to the Smith & Wesson revolver, later placing it each night on his bedside at the White House, according to paperwork kept by Roosevelt's longtime bodyguard and family friend, James Amos.
The firearm's history after Roosevelt's death in 1919 remains somewhat shrouded in mystery. What seems to be the most likely scenario, according to paperwork and personal accounts, is that the Roosevelt family gifted the revolver to Amos, who then turned it over to his family before it eventually landed with Jim Supica, the museum director for the National Rifle Association.
Amos, who was Roosevelt's valet for 12 years, was once referred to by the president as "the best shot that I have ever seen," according to the Theodore Roosevelt Center. After the president's death, Amos would go on to become a special agent with the FBI, joining in 1921 and becoming one of the first Black agents in the Bureau's history.
In a book about his time with Roosevelt, Amos wrote, "While President he often went armed. I have in my home now a large revolver which Mr. Roosevelt placed at the side of his bed every night while in the White House. It was given me by Mrs. Roosevelt after his death."
In addition to the revolver, Rock Island Auction Company also auctioned off an Ames-inscribed presentation sword and scabbard designed for Confederate Brigadier Gen. Paul J. Semmes, who was mortally wounded during the Battle of Gettysburg. The sword was sold for just over $175,000.
A separate Roosevelt-owned revolver, a Colt single-action variant that was special ordered around the president's 54th birthday, sold in 2020 for a shade under $1.5 million.
Observation Post is the Military Times one-stop shop for all things off-duty. Stories may reflect author observations.
Jon Simkins is a writer and editor for Military Times, and a USMC veteran.
Hoosier National Forest.
Washington: Senate Committee to Hear Firearm Permit & Waiting Period Bill
Virginia Senate committee advances bill toughening gun storage laws
NRA Sues in Federal Court Over Illinois Ban on Semiautomatic Weapons

redpajama_set_name: RedPajamaCommonCrawl


text:
Curds
Non-existant product
Bandon Cheese History
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Large pothole/crater
Closed 20:57, 3 Oct 2020, last updated 10:44, 28 Jan 2021
Failure to repaint road markings at corner of Sion Place and Gloucester Row
Road repair failed
Closed 08:11, 2 Oct 2020, last updated 10:28, 6 Oct 2020
Traffic Light Phasing
Large amount of foliage obstructing access to the pavement.
09:34, 28 Sep 2020, last updated 10:48, 3 Dec 2020
Pothole causing noise disturbance to nearby residents
Redisplaced curb stone on island in roundabout
Public toilets: external lights on 24/7 for past six months
Lights number three Clifton Park not working
Fixed 07:22, 25 Sep 2020, last updated 14:00, 5 Oct 2020
Street light, number five, York Gardens not working
Dangerous Road
No entry sign facing wrong way
Hotwell Rd - multiple lights STILL not lit
Corner of Sion Place and Gloucester Row: Yellow lines and parking spaces not repainted
Hotwell Rd - multiple lights not lit
Fixed 13:46, 7 Sep 2020, last updated 11:35, 10 Nov 2020
Approx 12" sunken / collapsed manhole in main east/south bound carriageway mid way through tunnel
This light does not work at night
A4 Portway. Lights 1, 3, 5, 7, 9 & 11 are not lit
Fixed 11:40, 4 Sep 2020, last updated 16:53, 18 May 2021
Support for railings adjacent to Merchant's Arms
Broken road surface
Closed 20:44, 2 Sep 2020, last updated 13:38, 23 Sep 2020
Scaffolding fronting 3 Granby Hill
Broken stone paver leaving hole and trip hazard.
18:12, 30 Aug 2020, last updated 15:26, 16 Sep 2020
Noisy man hole covers
Fixed 12:57, 29 Aug 2020, last updated 09:14, 1 Oct 2020
Tree uprooted
Loose man hole cover
Illegally Parked Vehicle
11:12, 28 Aug 2020, last updated 12:19, 7 Sep 2020
Gloucester street will form a sink hole here
I have reported two clanking manholes repeatedly. One fixed about two weeks ago soon started clanking as badly as ever but yesterday fixed as manhole cover broke again BUT MANHOLE COVER ON OTHER SIDE OF ROAD STILL CLANKS....PLEASE COULD YOU FIX IT.
Carboard not collected (again)
Cardboard not collected
Lifted manhole cover
Fixed 14:18, 26 Aug 2020, last updated 10:04, 25 Feb 2021
2 potholes
12:27, 26 Aug 2020, last updated 12:16, 11 Jan 2021
Signs around the roadworks have been moved by teenagers
Closed 19:09, 23 Aug 2020, last updated 12:25, 17 Nov 2020
Several potholes and poor road surface
Fixed 11:30, 19 Aug 2020, last updated 14:09, 11 Nov 2020
Slippery tactile paving on sloped pavement
The row of buildings, containing the Merchants Arms and The Vet have been hit 8 times in the last 10 years. An elderly gentleman was killed on the crossing last year. It is a very fast section of the A4. When the pavement was modernised recently, part of the job was to install railings, but this was cancelled as the job went over budget. Please make this corner and footpath safe.
Severe rutting to nearside of westbound carriageway
Severe rutting to nearside of carriageway
Closed 21:43, 13 Aug 2020, last updated 14:13, 22 Sep 2020
The only street light in The Paragon has not been lit for several nights at least.
Fixed 23:13, 11 Aug 2020, last updated 17:05, 17 Sep 2020
Damaged border stone of edge of roundabout
Motor cycle regularly parks on pavement outside my window
Noisy cover
Fixed 12:46, 28 Jul 2020, last updated 09:47, 27 Aug 2020
Extreme(and possibly illegal) noise pollution
Accident hazard for two wheeled vehicles
Blocked drain at base of cul de sac.
12:41, 24 Jul 2020, last updated 11:11, 18 Oct 2021
Damaged/dangerous cover
Two clanking manhole covers on A4
07:33, 20 Jul 2020, last updated 17:04, 17 Nov 2020
Covid19 social distancing being abused by Spicer and Cole,The Fringe public house and Fishers Resturant
Damaged stones following road maintenance work
Closed 11:09, 16 Jul 2020, last updated 10:02, 20 Aug 2020
Pothole on pavement - one foot
Damged paving outside 44 Regent St
Glass blocks on pavement missing
Drain Cover
Cul-de-sac sign damaged
Hotwells Primary School roadside barrier - Safety issue
Closed 14:16, 30 Jun 2020, last updated 00:05, 21 Jul 2020
Blocked storm drain directly outside the garden gate of St Vincent's Priory
Fixed 13:55, 30 Jun 2020, last updated 09:57, 11 Nov 2020
Another Report on Issue 2068114
Fixed 11:51, 26 Jun 2020, last updated 07:57, 3 Nov 2020
Road surface has pot holes a cyborg lanes which are getting bigger
Pot holes that stretch both lanes on the incline on bennet way
Shop obstructing pavement - Boyces Ave
Closed 11:48, 23 Jun 2020, last updated 10:07, 11 Jan 2022
After heavy rain water pours onto our property through a cable pipe
The beginnings of two more potholes in Cornwallis Cresc, immediately outside No.12.
Damage to my house
Badly blocked with silt and mud. Plants now growing in it!
Fixed 13:28, 1 Jun 2020, last updated 13:55, 22 Feb 2021
Cliff-edge fencing damaged
Fixed 12:04, 1 Jun 2020, last updated 19:37, 9 Feb 2021
Uneven surface and crumbling surface
08:55, 28 May 2020, last updated 07:55, 28 May 2020
Uneven lifting paving slab
This street lamp shines straight into our upstairs bedroom making it impossible to sleep. Even with blackout blinds installed.
Fixed 22:01, 23 May 2020, last updated 13:35, 4 Feb 2021
Deep pothole outside christ church
Fixed 20:55, 22 May 2020, last updated 14:39, 30 Jul 2020
Rubbish never collected
Closed 20:40, 22 May 2020, last updated 10:04, 11 Jan 2022
Blocked drain causing damage in my basement,
Fixed 11:54, 22 May 2020, last updated 08:15, 3 Nov 2020
Boundary wall fallen into street
Storm drain blocked, possibly causing damp in basement of busineses adjacent
A number of sizable potholes
Closed 13:13, 30 Apr 2020, last updated 15:26, 4 May 2020
Two blocked drains
Fixed 13:14, 24 Apr 2020, last updated 16:23, 28 Oct 2020
Drain completely blocked
Fixed 08:13, 24 Apr 2020, last updated 10:01, 22 Feb 2021
Completely blocked drain
Fixed 10:25, 23 Apr 2020, last updated 14:50, 9 Nov 2020
CRACKED hole cover, going to break soon
18:34, 17 Apr 2020, last updated 08:41, 22 Apr 2020
Light 9 not working in darkness at 9pm last night
Fixed 10:57, 17 Apr 2020, last updated 14:14, 15 May 2020
Fixed 10:55, 17 Apr 2020, last updated 17:00, 17 Sep 2020
Road surface causes large noise when HGVs pass
Closed 16:32, 14 Apr 2020, last updated 00:05, 30 Jul 2020
Dangling electrical cable in middle of footway.
Closed 16:11, 21 Mar 2020, last updated 09:55, 11 Jan 2022
Potholes again and again here
Closed 15:25, 19 Mar 2020, last updated 11:16, 27 May 2020
A drain is blocked that leads to flooding further down Clifton Down Rd
Fixed 15:11, 19 Mar 2020, last updated 09:29, 26 Jun 2020
Blocked drain causing flooding and danger to elderly pedestrians
Lots of large pot holes
Fixed 12:56, 19 Mar 2020, last updated 13:47, 30 Apr 2020
Missing sign on finger post
20:52, 17 Mar 2020, last updated 08:24, 1 May 2020
Overgrowing trees overhanging the bus lane
Closed 09:27, 17 Mar 2020, last updated 08:28, 17 Apr 2020
Light Bulb Replacement
Streetlight out on Wellington Terrace.
Large double potholes
Fixed 21:06, 9 Mar 2020, last updated 13:42, 17 Jun 2020
Potholes all along the upper part of Clifton Down
13:05, 9 Mar 2020, last updated 13:10, 9 Mar 2020
Potholes forming around previous patch job
Fixed 13:18, 8 Mar 2020, last updated 15:45, 27 Apr 2020
Issues with chute and building materials on the pavement on Hope Square.
Closed 11:41, 6 Mar 2020, last updated 23:05, 30 Mar 2020
Large section of road breaking up
Closed 13:42, 5 Mar 2020, last updated 14:51, 15 Apr 2020
Street lamp not working
Parking sign being used for bikes
Closed 09:00, 4 Mar 2020, last updated 23:05, 29 Jun 2020


text:
Source: INDYCAR
10.03.20 10th March 2020
Karam, DRR set for St. Petersburg, more races
In 2020, WIX Filters and the DRR team will participate in the 104th Indianapolis 500 presented by Gainbridge, set for May 24 at the famed Indianapolis Motor Speedway with Karam driving as well as at the NTT INDYCAR SERIES season-opener, the Firestone Grand Prix of St. Petersburg, as the primary partner on the No. 24 DRR Chevy. "We cannot thank WIX Filters enough for our outstanding association entering its eighth year with the Dreyer & Reinbold Racing team and now expanding our team's participation in the NTT INDYCAR SERIES this year," said DRR team owner Reinbold.
Road to Indy challengers set for open test
Pigot returns to Rahal Letterman Lanigan for two races
INDYCAR celebrates International Women's Day
Formula 1 2020: Your questions answered by Andrew Benson
Better Indy 500 among Herta's 2020 goals
Kimball lands primary sponsor for 500
Road Review: Lamborghini Aventador SVJ RoadsterHaas F1 2020 season aspirations, with Nominet Cyber Security
Everett Vaughan LO
Julio Chery XC
Test1 User on Bull RB16B goes extreme
It's Competition Time!
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Amy Schmidtke is program specialist in resource and program development. Her work includes developing materials for program development initiatives, identifying and synthesizing research-based resources to support the Institute's efforts, and helping coordinate growing program development partnerships, such as the Panhandle birth through Grade 3 community assessment and planning initiative. Schmidtke began working at the Institute in 2016 as a bilingual educational facilitator for the Superintendents' Early Childhood Plan. Schmidtke, who brings more than two decades of experience as an early childhood teacher and coach, spent 18 years with Omaha Public Schools and is an adjunct instructor in early childhood education in the Teacher Education Department at the University of Nebraska at Omaha. She has a master's degree in education from UNO with endorsements in early childhood education and English as a second language. Schmidtke earned a bachelor's degree in elementary education from the University of Nebraska ̶ Lincoln and is working on her Ed.D. in educational administration at UNO.


Copyright © 2014 Nathalie Rouas-Freiss et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Although various immune effector cells are recruited to the tumor site, their antitumor functions are downregulated, largely in response to tumor-derived signals . In this context, expression of the tolerogenic HLA-G molecule represents a mechanism that may favor tumor survival through interaction with inhibitory receptors. We will here focus on the ILT2 and ILT4 inhibitory receptors that are present on NK, T, B, dendritic cells, and neutrophils in which they mediate negative signaling that counteracts immune activation (Figure 1). The result is tumor escape from the host immune system . Thus, understanding such mechanism is an important challenge in order to develop optimal immunotherapeutic strategies.
Figure 1: Tolerogenic functions of HLA-G.
HLA-G has been shown to be expressed in many types of primary solid tumors and metastases and in malignant effusions . HLA-G can be found on tumor cells as well as on tumor-infiltrating cells . The clinical relevance of HLA-G in cancer is supported by the following observations: (i) HLA-G expression is associated with malignant transformation and is never observed in healthy surrounding tissues ; (ii) HLA-G is found to be expressed in solid tumors of high histological grades and advanced clinical stages [6, 7]; and (iii) the use of HLA-G as a prognostic marker has been proposed since HLA-G expression in biopsies and/or high levels of soluble HLA-G (sHLA-G) in plasma from patients have been significantly correlated with poor prognosis [6–11]. All these data highlight a role for HLA-G in the immune surveillance of solid tumors and the progression of the disease.
Regarding the relationships between tumor and immune system, the concept of cancer immunoediting has been described as an important host protection process that includes three essential phases: elimination, equilibrium, and escape . HLA-G can interfere with each of these phases. Indeed, (i) HLA-G can downregulate the elimination phase by inhibiting the proliferation of T and B cells, the cytotoxic activity of NK cells and CTL, the phagocytic activity of neutrophils, and the function of DC, via ILT2 and ILT4 signaling [3, 13–21] (Figure 1). In this phase, HLA-G expression would enable a proportion of tumor cells to evade the host immune response. (ii) Proinflammatory cytokines such as IFNγ which are secreted in high amounts may upregulate HLA-G expression . HLA-G could also affect the equilibrium phase by controlling the expression of HLA class II molecules by DC . (iii) In the evasion phase, tumor cells have lost molecules important for the immune recognition and tend to express only HLA-G on the cell surface, rendering them less susceptible to effector cells. The resulting rapidly growing tumors create a hypoxic microenvironment which promotes angiogenesis, invasion and metastases, but also induces HLA-G expression on tumor cells. Additionally, the immunosuppressive cytokine IL-10 which is produced in high quantities during this phase upregulates HLA-G expression . Both IL-10 and HLA-G may be produced by tumor cells but also by tumor-infiltrating leucocytes . Finally, HLA-G has been shown to induce regulatory T cells reinforcing tolerogenic environment [26–29]. All these mechanisms may profoundly alter antitumoral immune responses leading to tumor expansion and spread through blockage of both innate and adaptive immunity and by inducing tolerance to the tumor.
Recently, the development of animal models established the proof of concept that an HLA-G+ tumor cell can develop and tolerize the host antitumor immune response in vivo [30, 31]. Although there is no murine homologue of HLA-G, in vivo studies were made possible by the fact that human HLA-G can bind and mediate a signal via the murine receptor Paired immunoglobulin-like receptor (PIR)-B, the homologue of human ILTs [23, 32]. Results showed that human or murine tumor cells expressing HLA-G can grow in an immunocompetent host and that blocking HLA-G function by a specific antibody inhibits the development of the tumor. Characterization of the mechanisms by which HLA-G operates in vivo shows that both innate and adaptive immunity are affected [30, 31]. Hence, tumor proliferation is accompanied by an expansion of CD11b+ Gr1+ myeloid-derived suppressor cells, loss of peripheral T cells, and a cytokine balance in favor of a Th2 profile versus Th1/Th17. Therefore, blocking HLA-G may constitute a novel innovative antitumoral approach [2, 33].
Whereas HLA-G expression and its clinical significance in solid tumors have been extensively investigated showing that HLA-G expression in such tumor cells has unfavorable outcome or prognosis ; only a few data are available for the HLA-G expression and its clinical significance in liquid malignancies. In this regard, enhanced sHLA-G (i.e., HLA-G5 and shed HLA-G1) plasma levels have been described in B cell malignancies, such as multiple myeloma, non-Hodgkin B-lymphoma, and B-CLL [35, 36]. However, no clear correlation was established between HLA-G and unfavorable clinical outcome in hematological malignancies. Several factors may account for these controversial results such as clinical status, chemotherapy, and methodological differences between the studies.
Of note, discrepancy between solid and liquid tumors may be due to the nature of malignant cells: in hematological malignancies, tumor cells are immune cells able to express HLA-G receptors and HLA-G may have an unexpected role through inhibition of neoplastic cell proliferation. In this regard, we recently demonstrated that proliferation of hematological tumors expressing HLA-G receptor (ILT2) may be inhibited by HLA-G . Indeed, HLA-G inhibits the proliferation of human B cell lymphomas, myelomas, and B cell leukemia expressing at their surface the receptor ILT2. Blocking HLA-G or its receptor ILT2 by specific antibody or siRNA could restore B cell proliferation demonstrating the role played by the interaction between ILT2 and HLA-G in the antiproliferative activity observed. HLA-G was found to reduce B cell proliferation by inducing a G0/G1 cell cycle arrest. Signaling events leading to HLA-G inhibitory effects on malignant B cells were mediated through increased PKCα/βII, PKCδ, and PKCμ phosphorylation and decreased phosphorylation of AKT, mTOR, GSK-3β, c-Raf, and Foxo proteins. All these effects converge to activate inhibitors or to inhibit activators of cell survival, growth, and proliferation. Indeed, PKCδ and PKCμ phosphorylated active forms have been described to negatively regulate B cells . In addition, the mTOR pathway is a critical part of the cellular circuitry which is often constitutively activated in tumor cells. Our data provide evidence that HLA-G may inhibit tumor cell proliferation through mTOR signaling blockade. These results were consolidated by studies using bone marrow specimens from myeloma patients in whom HLA-G limits CD138− stem cell differentiation into CD138+ myelomatous tumor cells. Of note, we previously described the production of soluble HLA-G proteins by bone marrow-derived mesenchymal stem cells  as well as by osteoblasts . Analysis of cross-talk between tumor B cells, HLA-G+ mesenchymal stem cells, and osteoblasts in bone marrow may provide insights in understanding the mechanisms of tumor suppression in vivo in this biological compartment .
These data indicate a particularly innovative use of HLA-G in cancer since we propose a radically opposite action of HLA-G if the tumor cell is an immune system cell, the function of which could be affected by HLA-G due to the presence of surface inhibitory receptors for HLA-G. This does not involve blocking HLA-G to favor antitumoral response against solid tumor but, conversely, using the antiproliferative properties of HLA-G to limit tumor progression for hematological malignancies. Although, we are describing the role of HLA-G on B-cell malignancies, we can expect a similar effect on malignant blood diseases involving T cells, NK cells, and monocytes since these fulfil the same criteria as B cells (i.e., cell-surface expression of HLA-G receptors with inhibitory functions).
In agreement with this HLA-G antitumor activity in B cell malignancies, we previously showed that soluble HLA-G inhibits the growth of erythropoietin (EPO)-independent colonies in patients suffering from polycythaemia vera [41, 42]. This myeloproliferative syndrome is characterized by erythroid cells displaying deregulated proliferation due to a mutation (V617F) in the signaling protein JAK2, inducing autoactivation of this kinase by autophosphorylation . As JAK2 is directly related to the EPO receptor, this increase in activity leads to constitutive signaling of the EPO receptor and leads to the formation of EPO-independent erythroid colonies, one of the biological criteria of this disease. The patient presents proliferation of erythroid cells in the bone marrow which gives rise to hyperproduction of red blood cells, leading to polycythaemia in the peripheral blood. This disease has serious consequences since it may progress towards myelofibrosis with splenomegaly, or indeed leukaemia. Hence, the ability to thwart the effects of JAK2 V617F mutation could represent a major therapeutic benefit. Our research shows that the soluble HLA-G protein acts on protein kinase JAK2 by inducing its dephosphorylation. Notably, none of the known HLA-G receptors was found on erythroid cells leading to the hypothesis that HLA-G may act on this lineage through an unidentified receptor. Hence, soluble HLA-G may be perceived as a new negative regulator for the EPO receptor signaling and may therefore represent a potential therapeutic agent for the treatment of patients carrying the mutation JAK2 V617F found not only in polycythaemia vera but also in the other two main myeloproliferative syndromes, essential thrombocythemia and idiopathic myelofibrosis.
The HLA-G primary transcript is alternatively spliced leading to seven splice variants encoding 4 membrane-bound (HLA-G1 to -G4) and 3 soluble (HLA-G5 to -G7) protein isoforms. Although both membrane-bound and soluble HLA-G forms exert similar immunosuppressive functions through binding to ILT receptors, the soluble forms constitute the most relevant and adapted tools for therapeutic use. Nevertheless, the main obstacle to the implementation of soluble HLA-G as therapeutic is the absence of a form that is simpler than the complex trimolecular heavy chain/B2M/peptide with which the majority of data on HLA-G were obtained. Current knowledge on the multiple HLA-G active structures and their potential use in therapy is described in the following section.
This conception, which originates from the translation of in vitro experiments to the in vivo setting, is accentuated by the lack of analytic tools (especially antibodies) capable of specifically detecting anything more precise than "B2M-associated HLA-G," "unfolded HLA-G," or "secreted HLA-G," and might be incomplete at best. First of all, B2M-associated HLA-G and its interaction with ILT2 might not be the most important, or the most functional HLA-G structure in vivo. Indeed, cytotrophoblast cells express HLA-G heavy chains that are not associated with B2M for the lack of expression of this protein [47, 48]. Therefore, if the assumption holds true that HLA-G exerts its primary function at the fetal-maternal interface and that HLA-G functions in an identical fashion in other contexts in the adult, B2M-free HLA-G should bear high significance in the periphery as well. In this regards, in vitro studies demonstrated that B2M-associated HLA-G and B2M-free HLA-G molecules were identically capable of inhibiting the alloproliferation of T cells in mixed lymphocyte reactions . Knowing that B2M-free HLA-G binds ILT4 but not ILT2 [45, 49], it may be that ILT4 and not ILT2 is the receptor most relevant to HLA-G in vivo function. This notion is strengthened by recent data showing that ILT4 is the receptor for dimers of the alpha1-alpha3 structure of HLA-G (HLA-G2 and HLA-G6 isoforms) that is tolerogenic in vivo in murine skin transplantation models .
Atop of variations in its basic backbone and association with B2M, HLA-G can undergo posttranslational modifications. (i) It is long known that HLA-G can be glycosylated, especially when produced by trophoblast cells . More recently, (ii) it was demonstrated that HLA-G can also be nitrated . As nitration is produced at the site of nitric oxide production where the immune system is activated, HLA-G produced at sites of inflammation could be distinguished from HLA-G produced elsewhere. (iii) Due to ubiquitination, HLA-G can form high molecular weight complexes through disulfide bridges. These high molecular weight complexes are present in exudates from patients with inflammatory diseases or cancer and may also bear pathology-specific significance .
The notion that the function of HLA-G may depend on additional molecules is barely considered. Yet, given the diversity of HLA-G functions, it is very likely that all of them are not solely due to the interaction of HLA-G with its inhibitory receptors. It is entirely possible that the function of HLA-G is boosted by a synergy with other molecules, or reduced by others. In this regard, molecules that are functionally linked to HLA-G are already known. For instance, IL-10 is an inducer of HLA-G expression and is induced by HLA-G [24, 29, 54]. Similarly, indoleamine 2,3 dioxygenase (IDO) expression and/or function was shown to modulate and to be modulated by HLA-G [55, 56]. Amongst molecules that may deeply affect the function of soluble HLA-G are soluble HLA-G inhibitory receptors. Indeed, binding of soluble ILT2 or ILT4 to HLA-G is likely to block HLA-G function. Thus, parameters of the microenvironment might be crucial to HLA-G function. In addition, recent data confirm the original observation  that HLA-G is present in exosomes, in the culture supernatants of bladder cancer cells, and within exudates  and plasma (see Rebmann in ) of cancer patients. Exosomes are immune-active microparticles per se, either because of the external proteins they display or because of their internal immunomodulatory content or both. The actual function of HLA-G-loaded exosomes is yet to be elucidated, but it is likely that,depending on the exosome composition, HLA-G function might vary in terms of efficiency, and/or nature. Thus, exosome-bound and not-exosome-bound HLA-G may bear different pathological significance.
For lack of tools to specifically detect any of the HLA-G structures mentioned above, all get pooled into the "B2M-associated," "unfolded," or "secreted" categories, and, thus, their specific characteristics are not considered.
Analysis of the receptors that are responsible for HLA-G function in vivo represents also a critical point. This question may seem trivial since it is commonly admitted that HLA-G has two main inhibitory receptors: ILT2 and ILT4, that these are differentially expressed by all immune cells, and that they recognize different structural features of HLA-G (for review, see ). Yet, the situation might not be so simple as shown by a very simple fact: only 0–5% of CD4+ T cells, 10–15% of CD8+ T cells, and 20–25% of NK cells from PBMC express ILT2. How then, in mixed lymphocyte reactions and allocytotoxicity experiments, can HLA-G reliably inhibit PBMC T cells and NK cells directly through ILT2, ILT2+ cells and ILT2− cells alike? One possibility is that HLA-G does not act directly on the T cell or NK populations but on APCs (B cells of myeloid) which all express HLA-G receptors. Another possibility is that HLA-G does act directly on the T and NK cell effectors, but not through the ILT2 receptors that they express. We investigated this latter hypothesis.
In a first set of studies, we evaluated the capability of HLA-G to act through the mechanism of trogocytosis, that is, the transfer of membrane fragments and the proteins they contain from one cell to another. This work revealed that HLA-G can be transferred from cells that express it to cells that do not and still exert its function [60, 61]. We also demonstrated that not only HLA-G but also ILT2 could function through trogocytosis: ILT2-negative T cells acquired ILT2 from monocytes, transiently becoming ILT2+ T cells that could use this borrowed receptor to respond to HLA-G direct stimulation . Thus, trogocytosis of HLA-G receptors can explain the general inhibitory effect of HLA-G through known receptors on a cell population that in majority does not produce them endogenously, as long as some HLA-G receptor-expressing cells are present.
In a second set of studies, we investigated whether HLA-G could act through yet unknown receptors and we demonstrated, in systems where trogocytosis of HLA-G receptors was not possible, that cells which did not express HLA-G receptors could still respond to HLA-G stimulation. For instance, we demonstrated that HLA-G induced the upregulation of inhibitory receptor transcription in several immune cell lines including the KG1a promyeloblast line, which did not transcribe the known HLA-G receptors . In another study, we investigated the capability of synthetic HLA-G proteins to inhibit the cellular multiplication of hematological tumor cell lines. This had previously been reported for membrane-bound HLA-G1 and soluble HLA-G5 and was shown to occur through HLA-G/ILT2 engagement [37, 61]. We found that HLA-G synthetic proteins which were not capable of binding ILT2 could nevertheless inhibit the cellular multiplication of hematological cell lines. Furthermore, HLA-G synthetic proteins were shown to inhibit cell lines that did not even express known HLA-G receptors [42, 64]. The identification of such a novel HLA-G receptor and of its associated functions, the possible functional associations, or overlaps with the already known ones is crucial to HLA-G biology and to the clinical applications of this molecule, as well as to the determination of its cellular expression pattern.
In addition to the need of better defining in vivo active HLA-G structures and their interactions with other molecules from the microenvironment, the last part of this review is dedicated to the regulation of HLA-G expression, an additional critical point to elucidate in the context of tumors.
In healthy tissues, HLA-G molecules are absent with the exception of placenta [65, 66], thymus , pancreas , cornea , proximal nail matrix , and organs sustaining erythropoiesis . Nevertheless, ectopic expression of HLA-G is commonly observed in pathological situations such as cancer, not rejected allografts, virus infections, autoimmune diseases, and inflammation . In both normal and pathological contexts, the presence or absence of HLA-G is generally independent of classical HLA class I molecules and involves transcriptional, posttranscriptional, and posttranslational mechanisms.
Among key regulatory processes involved in HLA-G expression, DNA methylation (CpG) and hypoacetylation of H3 and H4 histones at the HLA-G locus have been associated with the absence of HLA-G expression commonly observed in cultured tumor cells expressing or not classical HLA molecules. The HLA-G gene repression can be reversed by demethylating agents used in some cancer therapies such as 5-aza-2′-deoxycytidine [71, 72] and inhibitors of histone deacetylases  and may directly induce HLA-G cell surface expression.
HLA-G transcriptional activity is also controlled by a unique machinery since almost all known regulatory sequences for classical HLA class I gene are disrupted for HLA-G gene, including some that are shared with HLA class II genes . Alternative regulatory elements have been identified such as a putative locus control region (LCR) contained in a 250 bp fragment at 1.2 kb from the ATG translation initiation site . The LCR was shown to be critical for spatiotemporal HLA-G transcription in transgenic mouse placenta . Among factors demonstrated to target this region, CREB1 factor was described by the group of Peter van den Elsen to bind two cAMP response elements (CRE) at positions −1381 and −1371 (3′ ends) from the ATG . CREB-1 was also demonstrated to bind two additional CREs scattered through the distal promoter region at positions −935 and −771 . In addition, we reported the location of a functional binding site for IRF-1 (−744) in response to IFN-beta  and binding sites for heat shock factor 1 (HSF1) (−459/−453) in response to heat-shock or arsenate treatments . Besides these regulatory elements, a binding site for the progesterone receptor (PR) was located at position −38 . Recently, HLA-G repressors have been identified by our group and others, including Ras responsive element binding protein 1 (RREB-1) which binds three Ras response elements (RRE) dispersed along the HLA-G proximal and distal gene promoter (−1357, −143, and −54) , GLI-3 factor (−1108) , and a LINE-1 element in which 3′ end is located at −4 kb . Interestingly, a hairpin loop can form in the LINE-1 element leading to HLA-G silencing .
HLA-G expression is also controlled at the posttranscriptional levels by mechanisms targeting the 3′ untranslated region (3′ UTR) that affect mRNA stability [78, 81] and by specific microRNAs (miR-133a, miR-148a, miR-148b, and miR-152) [82, 83]. At the posttranslational level, HLA-G expression is regulated by the antigen presenting machinery (APM) [84, 85] and a specific quality-control process mediated by the truncated HLA-G tail that control high affinity peptide loading and increases HLA-G cell-surface expression .
Environmental factors commonly found in placenta or tumors are certainly crucial in the induction, upregulation, and maintaining of HLA-G expression since HLA-G+ cells may lose HLA-G expression during long term cultures in standard conditions . These factors include cytokines (IL-10 , IFN-γ , IFN-γ+GM-CSF, IFN-γ+IL-12 [89, 90], IFN-β , and LIF ), hormones (dexamethasone, hydrocortisone , and progesterone ), galectin-1 , IDO , and stress conditions (heat shock  and hypoxia [94, 95]). These regulatory molecules exert a control on the amounts of HLA-G transcripts and/or HLA-G protein and for some may have the opposite effect (downregulation) on classical HLA-class I expression (IL-10 , glucocorticoid hormones ). In vitro experiments reveal that most of them require HLA-G basal transcriptional activity to have an effect. Among environmental factors able to reverse HLA-G repression, hypoxia, which is a common stress condition (cancer, transplantation, and pregnancy), is considered as a critical candidate [94, 95].
Otherwise, several lines of evidence are reported for balancing selection acting on the 5′ and 3′ untranslated regions of the HLA-G gene (5′ UTR and 3′ UTR) [96, 97]. Considering 46 HLA-G alleles (50 alleles have been recognized to date), six different HLA-G lineages are identified showing variations mainly in the regulatory regions . This indicates that these lineages are probably related to different expression profiles depending on microenvironmental factors and on physiological or pathological conditions.
Interestingly, at least 33 single nucleotide polymorphisms (SNP) are described in the 5′ UTR, defining at least 11 haplotypes [96–100]. They can modify potentially methylated CpG sites and are within or close to known or putative regulatory elements and thus might influence transcriptional activity [73, 100–102]. For instance, it should be noted that (i) a CpG site at positions −965/−964 may be affected by the presence of an Adenine at position −964 (0.5 frequency); (ii) the −56 C-T polymorphism coincides with the RREB-1 binding site located in the proximal HLA-G promoter region and is close to the PR element located at position −38 (iii) −762 C-T and −725 C-T-G polymorphisms surround the ISRE at position −744. Nonetheless, very few studies have investigated the impact of HLA-G promoter polymorphisms on the level of HLA-G expression. In particular, using luciferase reporter assays performed in JEG-3 choriocarcinoma cell line showed that a Guanine instead of a Cytosine or Thymine at nucleotide position –725 in the promoter region of HLA-G results in increased transcription rates .
Several polymorphic sites are also identified in the 3′ UTR, a 14 bp insertion/deletion (Indel)  and 7 SNPS (+3003T-C, +3010C-G, +3027A-C, +3035C-T, +3142G-C, +3187A-G, and +3196 C-G), defining at least 7 haplotypes with frequency >0.05 . The presence/absence of the 14 bp sequence has been associated with the magnitude of HLA-G production in normal and pathological situations . In particular, alleles presenting the 14 bp sequence are associated with reduced HLA-G mRNA and lower levels of sHLA-G in the plasma from healthy subjects [105–108]. Moreover, a minor fraction of HLA-G transcripts generated by the 14 bp alleles can be further processed by the removal of a 92 b fragment containing the 14 b sequence. These transcripts are more stable than the complete form and might be the consequence of the presence of an AU-rich element (ARE) within the 14 b fragment . Another variation site at position +3187 may also influence HLA-G mRNA stability, with the presence of an Adenine associated with decreased mRNA stability in vitro and decreased HLA-G expression . Interestingly, the SNP is found 4 bp upstream of an ARE. Furthermore, the nucleotide variation at the +3142 position was demonstrated to influence the binding of miR-148a, miR-148b, and miR-152 to the HLA-G messenger with an increased affinity in the presence of a Guanine instead of a Cytosine . Despite a controversial data published by Manaster and colleagues , these results are consistent with the in silico analysis of microRNAs targeting the 3′ UTR . Indeed, in addition to miR-148a, miR-148b, and miR-152, the binding ability of several miRNAs may potentially be influenced by the 3′UTR variations, emphasizing the role of the 14 bp indel, and SNPs at the +3003, +3010, +3027, and +3035 positions. Interestingly, we recently showed that most of 3′UTR SNPs are associated with differential amounts of sHLA-G in the plasma from healthy Brazilian and French populations . In agreement with the known or putative specific impact of each variants, UTR-1 haplotype (14 bp Del, +3003T, +3010G, +3027C, +3035C, +3142C, +3187G, and +3196C) was classified as a high producer of sHLA-G while UTR-5 (14 bp In, +3003T, +3010C, +3027C, +3035T, +3142G, +3187A, and +3196C) and UTR-7 (14 bp In, +3003T, +3010C, +3027A, +3035T, +3142G, +3187A, and +3196C) were classified as low producers of sHLA-G .
Therefore in addition to microenvironment factors, HLA-G gene polymorphism is likely a relevant parameter to consider in tumoral HLA-G expression.
Based on the tolerogenic properties of HLA-G in the solid tumor context, blocking its expression and function may be considered as potential targets for antitumor therapy. One might either stop HLA-G transcription or interfere with its surface expression or secretion or block direct interaction between HLA-G expressed by tumor cells and inhibitory ILT receptors present on immune cells. Strategies aimed at blocking HLA-G expression by using RNA interference or HLA-G function by using specific antibodies may enhance the immune clearance of HLA-G+ tumor cells since all cell subsets involved in tumor rejection can express at least one receptor for HLA-G. In hematological malignancies, such as B cell malignancies, the role of HLA-G seems more complex and may depend on a balance between the HLA-G-driven inhibitory mechanism of antitumor responses and the antiproliferative effects on malignant B cells which will be under the control of ILT2 expression or of another as yet unknown receptor (Figure 2). Accordingly, considering ILT receptor expression and function in malignant hematopoietic cells will be of particular importance in understanding the mechanisms of tumor progression in vivo. In this regard, more clinical and basic studies are now required to establish a clear significance of HLA-G expression in hematological malignancies. Finally, precise determination of the nature of the HLA-G molecular structures/superstructures that are pathologically relevant in vivo as well asthe identification of individuals genetically prone to differentially express HLA-G in a specific environment will contribute to develop optimal HLA-G-based clinical strategies for diagnostic and therapy in cancer.
Figure 2: Dual role of HLA-G in hematological malignancies.
This work was supported by the CEA.
L. Loumagne, J. Baudhuin, B. Favier, F. Montespan, E. D. Carosella, and N. Rouas-Freiss, "In vivo evidence that secretion of HLA-G by immunogenic tumor cells allows their evasion from immunosurveillance," International Journal of Cancer. In press.
K. Y. Howangyin, M. Loustau, J. Wu et al., "Multimeric structures of HLA-G isoforms function through differential binding to LILRB receptors," Cellular and Molecular Life Sciences. In press.


text:
Films: Cats
Big Day for Little Kittens, A
Louise Luther
"A most pleasant day with a little girl, her four kittens, and collie dog. The kittens do so many things that set them apart from other animals. They seem to enjoy their various playful activies before the flood lights and camera. While all this is going on, the collie feels just a little bit left out of things. Finally, all return to the barn for some fresh milk and a good night" PSA Journal, Nov. 1960, 39.
Black Cat, The
Lance D. Hayes
"The Black Cat is a 25-minute version of Edgar Allen Poe's story by the same name and concerns a man who does away with his wife in what he believes to be the perfect crime, only to be outdone in the end by the family black cat. This low key, well dramatized version is the only 8mm film among the top ten and also received the MPD Scenario Film Award" PSA Journal, Sept. 1965, 50.
House That Cats Built, The
Iwao Matsushita
"The 1938 Seattle film, shot by Iwao Matsushita, features chubby cats playing, eating, and being cuddled by their humans." K5 News.
Van Dee Sickler
"Under the classification of Home Movie, Van Dee Sickler of Los Angeles was awarded the $50.00 prize for his picture 'Mishcief,' a 16 mm subject in 200 feet. The continuity is evolved around his wife, a Scotch terrier, a cat and a bird. The continuity, titles and photography of this picture were very good." American Cinematographer, Dec. 1934, 376.
Nite Life
J. Kinney Moore
"A perfectly delightful holiday in personal filming, replete with humor, and imagination, is the comedy, Nite Life, produced by J. Kinney Moore, entirely in Kodachrome and, what is more, almost entirely in interior Kodachrome, by artificial light. Mr. Moore, in his work, refutes the contention, sometimes heard, that the amateur should be wary of film comedy. And, beside negotiating this pinnacle successfully, the producer has added an outstanding technical handling of Kodachrome, as well as a highly diverting and intelligent use of the various camera illusions it is possible to produce with the aid of modern 16mm. equipment. The obvious zest and pleasure with which the actor producer entered into the creation of this film add immeasurably to its value as a genuine document of personal filming achievement. Examples of carefully planned and executed trick photography follow one another in such rapid succession in the film that the spectator is left time only to gasp. However, these tricks are not executed simply for their own sake, but strictly in accordance with the furtherance of the plot. It must be said that, in the second part of the film, the author does yield slightly to the temptation of attenuating the action somewhat in order to spin out his bag of tricks. But the film as a whole is so delightful that any audience could easily forgive this small shortcoming." Movie Makers, Dec. 1936, 542.
On the Reef
Graemer Grosvenor
"On the Reef can refer to only one place in the world and that's the Great Barrier Reef off the eastern coast of Australia. Graemer Grosvenor handled the world of sea life very nicely with a smooth flowing story of a group of young adventurers in this area of the unusual. This film from Australia had no difficulty in capturing the Nature Film Award" PSA Journal, Oct. 1968, 49.
Scat, Scat
Harrison F. Houghton
"A Short, appealing story of the little kitten who had no home. A wonderful example of what can be done within four flocks of one's home. The cast includes Mrs. Houghton, their two daughters, a few neighbors, and the family dog and kitten" PSA Journal, Dec. 1955, 36.
"This was a sequel to his last year's picture 'Mischief.' It has the same characters, the dog, cat and bird with an addition to the dog and cat family." American Cinematographer, Feb. 1936, 73.
Squeaky
Walter Bergmann
"Every movie maker who owns a kitten probably has tried to film it; and, if so, he knows what a difficult task it is. Walter Bergmann has recorded, on film, incidents in the life of a stray kitten that is adopted by a soft hearted family. Reaction shots of a wise and dignified old cat express the disdain with which it views the foolish antics of the kitten, especially when the latter satisfies its curiosity about high places. Human beings in the film are introduced logically and unobtrusively, but Squeaky is essentially concerned with the star actor. Mr. Bergmann may be pardoned for occasional uneven exposure, for he has produced a film that will delight everybody, and especially those who love cats." Movie Makers, Dec. 1945, 496.
Squeaky's Kittens
"Last year's Honorable Mention Squeaky has grown up into a Ten Best and has had kittens to boot. In Squeaky's Kittens, Walter Bergmann presents the mother cat rearing her four lively offspring with the help of the Bergmann household. With what must have taken a great deal of patience and dexterity, the kittens are shown being fed and playing and sparring in typical fashion. Their inevitable disposal among the neighbors constitutes a delightful sequence in which the children and grownups of a suburban community are depicted in wholly natural and pleasing manner. Mr. Bergmann's manipulation of lighting, both interior and exterior, is warm and skillful, and he has supplemented the story with titles in light vein that are inserted with restraint." Movie Makers, Dec. 1946, 486.


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Gasp! Bigfoot 'body' is a rubber Halloween costume
By Shelby Martin |
PUBLISHED: August 19, 2008 at 4:40 p.m. | UPDATED: August 15, 2016 at 6:10 p.m.
Melting ice uncovered a hoax this week, as the "Bigfoot" found in a Georgia woods turned out to be . . . a rubber Halloween costume.
Bigfoot hunters Matt Whitton and Rick Dyer had tossed their find in a freezer and frozen it in a solid chunk of ice – to preserve it, they said. The two men finally turned over the freezer and on August 17, Bigfoot enthusiasts waited with bated breath as the apparent body slowly defrosted.
After hours of waiting, a dark patch of hair emerged. Steve Kulls, Executive Director of Squatchdetective.com, told Fox that he extracted a hair sample and burned it. It was apparently made of synthetic fibers and "melted into a ball uncharacteristic of hair," Kulls said. An hour later, the group's fears were confirmed when further melting revealed a rubber foot.
"It's heartwrenching," said Bob Schmalzbach, Vice President of Searching for Bigfoot, Inc, in an interview with Fox News. "We thought it was the answer to a mystery that's been going on for too long."
As of Tuesday, the two Georgia men who perpetrated the hoax were nowhere to be found. According to the Web site of Searching for Bigfoot, Inc, the organization plans to pursue legal action against the men.
Not everyone is upset about the news of the hoax. The Bigfoot "body" is thought to be a $450 Sasquatch costume from online costume retailer TheHorrorDome.com. Owner Jerry Parrino declined to release any numbers, but said business has been good.
"Sales of our Sasquatch costume have gone up," he said.
Contact Shelby Martin at smartin@mercurynews.com or (408) 920-5427.
Shelby Martin
Police: 2 California men arrested with nearly 1,000 pounds of marijuana in camper
Activision's CEO Is looking at $375 million payday in Microsoft sale


These earrings are Clip-On's and are made for non-pierced ears. If you are looking for earrings with posts for pierced ears kindly refer to item ER061CS.
These beautiful floret button clip-on rhinestone earrings blossom with sparkle. Perfect for dancers or performing groups. 100% nickel-free silver plating. Individually wrapped in cellophane and carded.
These earrings have "clips" for non-pierced ears. Please see item ER061CS for the same product with posts for pierced ears.


It has come to my attention we actually don't ever hear the name of a currency in game; If anyone has any leads, please tell me about it, it may come in handy later on.
Since the town was made by Dorothy, it seemed sort of logical that when it comes to money, she'd use something familiar. Dorothy being from Kansas, the dollar is a good name for a money.
Just like in any sort of fantasy setting pretty much.
The old Italian money, since the English translation of the game seems to use a lot of italian words. Also it fits the whole idea of the mafia.
Just one we'd completely make up, with its custom name and values.
Frankly, I have no idea. I guess dollar is pretty generic. We can use that.
The reasoning regarding using dollars makes sense, I'll go for that.
I think using dollars would be the best thing, since its a well known currency.
I know it's already decided, but I think gold/silver/copper coins could work really well too! also a very common currency in fantasy-esque worlds.
dollar works too though, I just thought wasn't sure if that technology was available in this town. or people might be like, "Who is this old guy on this here dollar bill?" xD haha. plus, the value of paper money is backed up by valuables like gold and silver anyways, so coins might just be easiest.


text:
Attracted to open access journals: A bibliometric author analysis in the field of biology
Tove Faber Frandsen 1
1 RSLIS - Royal School of Library and Information Science
Tove Faber Frandsen 1 AuthorId : 356460
1 RSLIS - Royal School of Library and Information Science (Birketinget 6 2300 København S Denmark - Denmark) StructId : 74365
Biblioteksskolen (France) StructId : 319895
Abstract : Purpose - Scholars from developing countries have limited access to research publications due to expensive subscription costs. However, the open access movement is challenging the constraint to access. Consequently, researchers in developing countries are often mentioned as major recipients of the benefits when advocating open access (OA). One of the implications of that argument is that authors from developing countries are more likely to perceive open access positively than authors from developed countries. The present study is an investigation of the use of open access by researchers from developing countries and is thus a supplement to the existing author surveys and interviews. Design/methodology/approach – Bibliometric analyses of both publishing behaviour and citing behaviour in relations to OA publishing provide evidence of the impact of open access on developing countries. Findings – The results of the multivariate linear regression show that open access journals are not characterised by a different composition of authors than the traditional toll access journals. Furthermore, the results show that authors from developing countries do not cite open access more than authors from developed countries. Originality/value – This paper argues that authors from developing countries are not more attracted to open access than authors from developed countries. Keywords – open access, bibliometrics, author analysis, developing countries. Article Type: Research paper
Humanities and Social Sciences / Library and information sciences
Contributor : Tove Faber Frandsen <>
Submitted on : Friday, October 10, 2008 - 8:50:10 AM
Last modification on : Wednesday, December 2, 2015 - 8:26:00 AM
Long-term archiving on: : Monday, June 7, 2010 - 6:02:49 PM
Author_analysis.pdf
Tove Faber Frandsen. Attracted to open access journals: A bibliometric author analysis in the field of biology. Journal of Documentation, Emerald, 2009, 65 (1), pp.Forthcoming. ⟨hprints-00328270⟩


Yesterday word got out that rapper Mac Miller had been found dead from an apparent drug overdose. Not many details are out yet, but that's the jist of it so far. He was just 26. He just released, in my opinion, a really great album Swimming, and was starting his new tour next month. But now he's gone.
He paved the way for a lot of frat rappers and just innovative music in general. He started out as "easy mac with the cheesy raps" and then became the name that we know today and forever as Mac Miller...the artist who pushed the boundaries and showed true vulnerability and transparency in his lyrics.
I never saw Mac perform, but for some reason this celebrity death hits home for me. I am not sure why. I think because his newest album Swimming is so good. And it was hopeful. He seemed to be in a better headspace, and moving on after the troubles he had in the public. Of course, you never know exactly what someone else is going through unless you are that person.
I recently wrote about how I liked his cover versions of Bright Eyes' music so much more than the original songs themselves. Listen to some of my favorite Mac songs below.
The above song Poppy really helped me get through my grandfather's passing years back. It made me cry every time, but it was nice to hear something I could relate to. It really helped me.
I really will miss you Mac. You were so rare. So refreshing the music industry.
Thank you for the music. It won't stop playing.


Around the year 1332 the Hungarian Kingdom which invaded and occupied Transylvania, decided, because of the attacks of the tartars which after the mongol invasion from 1241, remained in the north of the Black Sea to made a region of protection of Transylvania, where to fight with the tartars, in Moldova, to the east of the Carpathians. Here the region were habituated by the Romanians as well and therefore , a Romanian from Transylvania, Dragos, a nobleman too, were sended by the Hungarians to organise this defensive region. Going one day to hunt buffaloes, his female dog, named Molda, were drown in the water of a river. In his memory that river were called Moldova and from it were named the country too, Moldova. Here the medieval state were founded in 1365 by another Romanian from Maramures, Bogdan.
Moldova starting with 1372 starting to be rulled by the Musatin family called like this after the name of Lady Musata. This territory have the highest development in the Xv-een century under the rule of Stefan cel Mare, a real defender of Europe against the Ottoman Empire. To understand easier what I am talking here, consider that, today a single man and his army, will keep ISIS away from Europe. In 47 years on the throne he fight in 44 battles and lost only 2. After each victory he built a church or a monastery. Many of them are still standing today, and others were built by his nobles or son, Petru Rares. Are known today as "the painted monasteries" and are part of UNESCO Heritage for their beautifull exterior and interior frescoes which still resist after more then 600 years.
The symbols of those paintings are original and unique in the world. Also the wine and food of this region are known everywhere in Romania for their quality and the landscape is really beautifull. Also one of the oldest salt mines from Romania is still preserved here like in 1883 which makes from Cacica a visited objective from Moldova. The mine is still working and produce salt.
The region is a mixture between the occidental influence and the oriental one and in 1602 here were built the Dragomirna Monastery where we can observe baroque influences in architecture , like a beginning of what will be this style in Romanian Moldova.
Here we can taste one of the best wines of Romania, Cotnari and this is the region which in the XIX century produced one of the most important, poets, novelists, painters and politicians of Romania.


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Subject: Warren Buffett: America Will "Work Fine" Under President Trump
URL: http://mney.co/2iT7jHd
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Follow Your Money & Politics
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Warren Buffett: America Will "Work Fine" Under President Trump
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Berkshire Hathaway Chairman and CEO Warren Buffett
Yesterday, Warren Buffett, the chairman and CEO of Berkshire Hathaway Inc. (NYSE: BRK.A; BRK.B), said he thinks the United States will "work fine" under President Donald Trump.
His reason: America's got the "secret sauce" – the ability to survive.
"America works," Buffett told CNBC on Thursday (Jan. 19). "I've said this before. It'll work wonderfully under [former Democratic presidential candidate] Hillary Clinton, and I think it'll work fine under Donald Trump."
The billionaire also conceded that he doesn't think the United States works perfectly, "but you just look at where we go, milestone after milestone. Never bet against America."
Buffett likewise took the CNBC interview yesterday as an opportunity to reiterate his call to invest now for the long haul…
Warren Buffett: The Stock Market Will Be Higher in the Future
The Oracle of Omaha said that he doesn't know where the stock market will go in the next "10 days or a year or two years."
But one thing he said he does know: "It's going to be higher 10 years, 20 years from now."
"There will be hiccups from time to time in the economy," Buffett cautioned. "[But] we'll do well over time."
Don't Miss: This "bible of weed investing" reveals the world's top marijuana stocks every serious investor should consider right now.
Since the election last year, Buffett has struck a more conciliatory tone toward Trump and has repeatedly called for unity in the months since the real estate mogul's official election.
This has likewise been the case for Mavericks owner and "Shark Tank" creator Mark Cuban, who in December claimed that Donald Trump was his "number one draft pick" – a statement completely contrary to the many criticisms Cuban had publically made about Trump over the course of his presidential campaign.
Here's more on Cuban's dramatic "change of heart"…
Tags: Warren Buffett
Your Money & Politics (this article)
BRK.A 465.00 (0.13%) 344970.00
BRK.B 0.47 (0.20%) 230.20


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Hunter Quotes
You've just got to manage your time and do as much as you can, and not place too much emphasis on one or the other. You try not to waste your time. - Charlie Hunter
You've got to give the Suns credit for their execution. I think we played even with them, although they had a lot of great hustle plays to gain the advantage. But this is just the first game. We've got to go back to the drawing board. - Lindsey Hunter
You've got to decide what's going to hurt. You can't really put a number on it. Donald Trump obviously has a different threshold than others do. - Bob Hunter
You've got a lot of guys out there now who have been diving for a long time and to ask them to go along and get a medical certificate to go diving, a recreational activity, it's like asking a hunter to get a medical before he goes hunting. - Jeff Vincent
You've always got to be on top of your game when you're out there hunting. Some of the more common accidents we see are the victim out of sight of the shooter. One hunter swinging out of his zone of fire and shooting possibly his hunting partner. - Brent Ward
You're going to see some pretty stiff penalties coming out of this. - Jim Hunter
Your client was familiar with him and had seen him earlier that day. While we were there (known substance abusers) came to the back door asking about him. - Paul Hunter
You wouldn't get that in England or America! - Ian Hunter
You who choose to lead must follow. But if you fall, you fall alone. - Robert Hunter
You watch how teams are defending it. Do they play a box or a diamond? Do they come after you or sit back? - Dale Hunter
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lt-test_tscore is a Catch v2.2.2 host application.
Sigh. I should probably take that out entirely, it's just too variable across operating systems.
Fix apache#5108: Remove OS dependency in test_BufferWriterFormat.cc.
UrlRewrite: separate constructor and configuration loading for testability.
Fix #5108: Remove OS dependency in test_BufferWriterFormat.cc.
Fix a self detection issue where parents are not marked down when proxy.config.http.parent_proxy.self_detect is set to 2 because of multiple calls to creatHostStat() which was marking parents back up. Also added a new HostStatus Reason Code SELF_DETECT used when self detection marks a parent down.
Add virtual destructor to SSLMultiCertConfigLoader.
Change url_mapping::toUrl to url_mapping::toURL for consistency with url_mapping::fromURL.


Watch: MM Srilekha's Valentine's Day special song 2018 - p..
Watch the exclusive promo of Valentine's Day special song composed by MM Srilekha. Srilekha, who is the cousin of great director SS Rajamouli and Music composer MM Keeravani, has started her film career as a playback singer at an age of 12. Srilekha, who has turned a music composer with the movie Tajmahal in 1995, has scored music for more than 50 films in a span of 20 years. Srilekha is the only female music director in the Telugu film industry.


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Piers Hellawell: Up By The Roots
In a long and distinguished career, Piers Hellawell has produced a body of work characterised by boundless invention, genuine discovery and deep integrity. Here, with his second release on Delphian, his enduring creative partnerships – forged through nearly 40 years of composing – are reflected in music that combines arresting surface gestures and sounds with a powerful underlying vision, resulting in pieces that both encourage and reward repeated hearings.
Professor Piers Hellawell is Professor of Composition in the School of Arts, English and Languages in The Queen's University of Belfast, where he has taught since 1981. His music is published by Edition Peters (London) Ltd.
"Piers Hellawell's music is as refreshing as it is alluringly strange...there is a visceral energy that gives it a sense of the here and now. Much of that is down to pulsating performances by varying scales of instrumental scoring, from the dense virtuosity of the Ulster Orchestra in Wild Flow, to the rhapsodic other-worldliness of Piani, Latebre, performed by solo pianist William Howard. Between these extremes are cello and piano duo Paul and Huw Watkins, in the wistful timbral experimentation of atria; the five-strong Hard Rain Soloist Ensemble's delightfully puckish performance of Ground Truthing; and Hellawell's hypertensive setting of Sinéad Morrissey's poem Up by the Roots, narrated by the poet with intoxicating instrumental backing by the excellent Fidelio Trio."
"Without exception, all the performers relish the technical fluency of Hellawell's scores; the variously sourced recordings are uniformly first-rate and the composer's booklet notes helpfully explain such enigmatic titles as Piani, Latebre and Ground Truthing"
"The title piece, a melodrama to poems about the plight of migrants, read by the author Sinéad Morrissey, does, though, invest its piano-trio medium with tremendous force."
"This disc of music from the last decade showcases the sheer diversity and strength of composer Piers Hellawell's work ... his music is characterised by a toughness and seriousness, he expects his listeners to pay attention. And if you do, the rewards are great as not only is his sense of structure highly inventive and satisfying, but he has a remarkable ear for colour. So this might be serious stuff, but it isn't dour, the music is full of colour, timbre and imagination. The performances on this disc are superb, and many of the artists are ones with whom Hellawell has worked for some time, thus creating a powerful and satisfying showcase."
Producer: Chris Corrigan
Release date:28 February 2020
Category: Fidelio Trio, Huw Watkins, Orchestral, Paul Watkins, Piers Hellawell, Sinead Morrisey, Ulster Orchestra, William Howard


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Archbishop of Wales' Lent Appeal supports Nordoff Robbins!
We are delighted to have been nominated as a chosen charity in the Archbishop of Wales' Lent Appeal!
The appeal asks members of the parishes of Swansea and Brecon Diocese to consider supporting one of four chosen charities. Nordoff Robbins was nominated to benefit from the appeal by Reverend Alison Jones, the Vicar of Swansea St Nicholas on the Hill and St Jude Parish.
Alison has been a great supporter of our work in the community of Townhill, Wales, where our music therapist Jo runs weekly community music therapy sessions at St Nicholas Church Hall. The service provides one day a week of music therapy sessions for children and adults, who are living with a range of challenges including autism, learning disabilities, mental health problems and acquired brain injuries. People travel from across Swansea and the wider South Wales area to access the service, as well as pupils from the local primary school and residents from the local community.
Our music therapist Jo spoke of the support Alison has given saying:
"Alison has been a huge supporter of Nordoff Robbins from the beginning, allowing us to rent St Nicholas' Hall at a reduced rate and being proactive in promoting the service and helping us make vital links in the local community. She has been incredibly welcoming and supportive and even invited one of the individuals I work with to perform at St Nicholas' community carols service last Christmas, which was an enormously positive and enriching experience for the person involved."
Reverend Alison said:
"Jo is an amazing music therapist who uses our church hall each week and is a really good community resource for such an area, which has a high rate of deprivation. She has brought real fun and laughter to our seniors group as well as to the individuals she helps, and to the school SDF unit… a bit of extra help might mean Nordoff Robbins could work in other parts of Wales as well."
All of us at Nordoff Robbins are incredibly grateful to Reverend Alison, and to the parish members who are supporting our life-changing music through the Archbishop of Wales' Lent Appeal. Thank you for helping us to reach even more vulnerable and isolated people with music!
Find out more about Archbishop John's Lent Appeal
O2 Silver Clefs 2019 raise a record-breaking amount for music therapy
A host of stars were honoured on Friday 5th July at the annual O2 Silver Clef Awards, raising a record-breaking total for our life-changing music therapy.
NICE recommend music therapy for dementia
The National Institute for Health and Care Excellence (NICE) has recommended that people living with dementia should be offered music therapy, as part of their updated Quality Standard on dementia.


Navya Nair Age 32 Years Old, Her Height 5 ft 3 in (163 cm) and Weight 58 Kg (128 lbs). Her Body Measurements 32-26-32 Inches. Navya Nair Bra Size 32B, Waist 26 Inches and Hip 32 Inches. Her Hair Color Black and Eye Color Black. Navya Nair Shoe Size 8 (US) and Dress Size 4 (US). Her Star Sign Not Known and Religion Hinduism. Let's Read Navaneet Kaur, Nausheen Sardar Ali & Nauheed Cyrusi Biography.
Navya Nair Father name Raju and her mother Veena Raju. she did higher schooling from MSM Higher Secondary School. Navya Nair married to Santhosh Menon in 2010. Navya Nair Husband Santhosh Menon. The couple has one son name Sai Krishna.


AES makes moving forward easier than you think.
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When Crypto and Blockchain Become Mainstream, What Will Be the Future of Investment?
While Crypto and Blockchain become Mainstream, what will be the future of investment?
Cryptocurrencies are becoming a matter of interest for banks and governments all over the world. Not long ago, bitcoin was only a mere nerd-y topic, but now it is making headlines on all the papers. The main economic institutions are preparing to introduce regulations, and investors are at its highest strong betting hefty for their rapid growth. All of this is happening while the volume of the crypto market cap has reached more than 500 billion dollars. We are overseeing, indeed, a monetary revolution.
The crypto world became so important that last week Barclays' CEO for personal and corporate banking, Ashok Vaswani, revealed the lender had opened discussions with UK regulators about adopting digital currencies.
Vaswani's comments came after several central banks from across Europe and Asia said they were looking into establishing digital-only currencies in addition to traditional denominations.
This just reinforces what it is already known, cryptocurrencies have become a mainstream topic. Its importance is due to the potential cryptocurrencies have in tumbling the current monetary model and the capitalist system itself.
But not only good things are to be expected with cryptocurrencies. Experts and opinion makers all over the world, have warned about their dangers while boosting their potential. Indeed there are perils and danger inside the crypto world and a new investor should proceed with extreme precaution.
A conference about the future of cryptocurrencies and blockchain will be held by blockchain expert Dinis Guarda on Wednesday, 20 at 5.30pm in London.
At the 3, Noble Street, Dinis Guarda and top experts Martin Bartlam, Jonny Fry, Derin Cag, Genevieve Leveille and Athanassios Kollyris will discuss the crypto world and the future of the democratization of investing and trading.
These conferences and events just show how big the crypto world is getting to. If the market cap has recently reached $500B is because there are hundred of thousands of investors behind it, supporting its growth and have seen such a breakthrough in the blockchain technology.
Indeed, cryptocurrencies hold a series of characteristics that make them almost stronger than any other physical-money based currency already out in the market. Its key, being created out of the next revolution happening in the always-evolving digital world is the blockchain.
The blockchain, the back-end technology where all -or almost- cryptocurrencies are based, implies a democratization of the monetary system that can hardly be seen in recent times. Everyone can access to this code behind a specific currency and thus everyone can watch that no one is taking shortages towards their own benefit. These two traits are core to crypto money, and their growth and development in the near future is inevitable, to say the least.
"There's a number of reasons why cryptocurrencies are so inherently popular. They are safe, anonymous and utterly decentralized. Unlike conventional currency, they are not controlled or regulated by some singular authority, their flow is determined entirely by market demand. They are also nigh impossible to counterfeit, thanks to the paranoidly complicated code system that encrypts each and every transfer, ensuring complete anonymity and utter safety to each and every user. They even make for a genuinely rewarding, if risky, investment endeavor, despite the fact that any financial advisor in their right mind will caution you against them.
In this cryptocurrencies fever, both investors and entrepreneurs are taking over the financial sector, and hundreds of new start ups are flourishing unsurprisingly following the cryptocurrencies main pillar, democratization.
The cryptocurrencies are setting off and they cannot be stopped. Governments and banks are trying to follow this since it has become mainstream, and have tried to regulate it. We will need to wait and see, bearing in mind that, as we have seen with the Internet, how people creatively keep claiming what its theirs, since it doesn't belong to anyone and is at the same time, from everyone.
That is, the power and promise of blockchain.
Thought leadership series on new trends and blockchain, powered by Humaniq.


And oh boy, do you. Literally.
I love ComicCon. This shouldn't be much of a surprise to all of you who read my previous post about Forbidden Planet. ComicCon is the amalgamation of nerd culture at its finest, and it's simply amazing how accepting everyone is with it. Put a lot of effort into dressing up? Awesome, dude! Not wearing a professional costume? That's cool too! You're a fully-bearded man dressed up as an anime girl in a bright pink minidress and a light-up chainsaw? The world is your oyster, my friend. No matter what it is, at MCM, you'll rock it.
I am a huge supporter of cosplay. It's fun to make and it's fun to do. This year, I went as Sera from Dragon Age: Inquisition, and I put in about three weeks' worth of on and off-work to make my bow and quiver, as well as my tunic.
There has never been a time where I thought my sewing skills would come in handy** but for once, in costume as a character who dresses tattily and cuts her own hair, it was a blessing rather than a curse. Last year, my sewing abilities did me no favours when I dressed up as Rose Quartz from Steven Universe, but the huge wig that gave me a bit of a headache after an hour probably distracted everyone quite well.
Even then, literally nobody at MCM bats an eyelid, because at least a third of the people there are in costume. Everyone is so busy looking at everything there is to offer that there's simply no time to be haughty anyway, because not only is MCM welcoming, but it is HUGE.
Whether you go through Comic Village or simply browse the trinkets in Pop Asia, there is something you will want. My friend, dressed as Link from The Legend of Zelda, has a tradition of buying a lucky cat there every year. I myself, as you may remember, am quite easily swayed by Funko Pops. I bought three – Garnet, Amethyst and Sailor Mercury – finishing up my Steven Universe collection and launching my Sailor Moon one.
There is also plenty of food inside, but be prepared to spend money – unfortunately nothing at Comic Con is cheap! I myself had some karaage (fried chicken balls) and a melon soda, and sat eating it on the floor as I watched cosplayers that went by, an island of peace in a day that otherwise never stopped moving.
There will always be more things you want to buy. Usually, I will buy some form of comic, but this time around I had to give it a miss. That being said, when your oldest friend works for a big UK comic publisher (Sweatdrop Studios – check them out) she does give me some books for free, so I am usually set on that front. It is one of the only times I ever get to see her any more, though it was hilarious watching her huddled behind her stall wrapped in blankets because she sat directly below the aircon.
Just one of the little personal reasons I love MCM, I suppose.
Last of all, a lighter as red as my tunic, and no doubt as red as my face, after so many hours of what was basically non-stop walking – hence why my photo is a bit blurry. I was very much starting to shake from tiredness by the end of it all, though – despite how exhausted I am for the days following ComicCon – it's always somewhere that I look forward to coming back to.
Also, when people stop you and compliment your costume and ask to take your picture, that doesn't hurt either.
*Sadly I did not get a picture of this cosplayer, but he really… TRUMPED THE COMPETITION. HAHAHA.
** I have friends who can do wonders with fabric. They can sew their own dresses from scratch, making designs straight out of their heads. I am lucky if I can keep two pieces of felt together.


Root canal treatment is necessary when a tooth becomes non-vital due to trauma or deep caries that has reached the inner layers of the tooth (pulp).
The root canal treatment procedure involves complete removal of the pulp (tooth's vessels and nerves) which lies on the tooth's roots, cleaning the roots from bacteria and their toxins and finally filling the roots with a special filling material (ghuttaperka).
The whole procedure is performed under local anaesthesia, is painless and is completed in one or multiple sessions, depending on the tooth's initial condition and the complexity of the roots' anatomy.
Usually, a tooth that has been root treated is subsequently restored with a crown, as it is quite fragile and large amounts of its structure are missing.


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HTC 10 specs leak via benchmarking sites
By Rose Behar
Looks like we won't have to wait until April 12 to find out what's under the hood in the HTC 10.
The Taiwanese company's forthcoming smartphone has appeared in benchmarking databases GFXBench and Geek bench, revealing the truth behind spec rumours that have been circulating for the past several months.
According to the benchmarks, the 10 features a Qualcomm Snapdragon 820 processor, which does not come as a surprise after Qualcomm tweeted an image revealing that the 10 will follow in the footsteps of the Samsung Galaxy S7 and LG G5 and feature one of its Snapdragon chips.
The HTC 10 is also equipped with 4 GB of RAM, and will include at least 32 GB of internal storage. The screen has Quad HD resolution with a 5.1" display.
As for the camera, the benchmark documents reveal a 12 megapixel back-facing camera and five megapixel front-facing camera.
Related reading: HTC 10 teaser points towards camera with UltraPixel sensor, OIS and 4K video capture
Source: GFXBench/Geekbench
The HTC team Google acquired built the Pixel 3a
HTC U11 vs. HTC U Ultra vs. HTC 10: What's the difference?
HTC Vive Pro Eye now available in Canada for $2,149 CAD
HTC's upcoming summer sale discounts the U Ultra by $300


Taking care of yourself is one of the most important skills that can help with managing your anxiety. This means making time for yourself. Even if it's just to take a mid day nap, meditating, listening to music, or simply taking a time out and stepping can help clear your head and decrease your anxiety.
Physical activity can help reduce stress and anxiety. Try heading out for walk or even jog whenever you start feeling anxious.
Do not skip any meals. Remain hydrated and limit your alcohol and caffeine, which can aggravate and trigger panic attacks, and keep healthful, energy-boosting snacks on hand.


Call/Send switches are used to move the stair lift chair without anyone being on it. This is especially practical if two people utilize the lift and the lift is at the opposite end of the track when a user wishes to use it. the user just calls the lift to come to them using a call/send switch. Another use of call/send switch is to send the lift away after use. Some individuals do not like the appearance of the lift parked in the main living area of the home in River Falls and will send it to the opposite end when not in use. They just call it back when needed.
Power supply – While a lot of stair lifts are battery ran today all model will need a power supply to either charge the battery or power the system directly when it comes to non-battery powered units. Non-battery powered stair lifts draw a great deal of power and normally need a devoted circuit.
Call/Send Controls – Call/Send controls are normally installed on the wall near each end of the stair lift track to provide a way for a user to call the chair to them or send it away when not required. They can be either cordless or wired to the lift depending on the model.
Foot Rest – The foot rest of the stair lift is a safety function to prevent the the users feet from hitting the steps while using the lift and a comfort feature to support the user's feet when resting on the seat. The foot rest will have switches constructed into them to stop the lift ought to it strike anything on the stairs and will turn up out of the way when the lift is not in use.
Transmission – Because the motor turns at expensive a speed to safely propel the stair lift the track at type of transmission is utilized to lower the speed while increasing the power readily available.
Battery Charger – Battery powered stair lifts need to have a charger of some sort to keep the battery charged. The chargers are generally found under the track or near one end of the track. The battery charger works instantly without any action needed by the user.
Battery – The batteries used in stair lifts are fairly expensive and found within the base of the seat near the motor. They will need to be changed at some time however their life expectancy is measured in years and thier replacement must not be a big concern.
Outdoor stair lift Limited movement is an issue for many seniors and an issue for their families in River Falls. Seniors who want to stay in their houses and remain independent can enhance their movement and stay safe by installing a stair lift.
A stair lift can transfer you or a loved one securely from one floor to another at home. A stair lift can supply a safe ways of transportation so that you will not have to fret about the threats of falling on the stairs. It is a particularly good choice for a senior citizen who lives alone.
Stair lifts been available in a range of sizes and capacities. Compact models accommodate and provide mobility for narrow staircases, supporting up to 350 pounds while doing so, and at the other end, heavy-duty stair lifts use a broader seat and can deal with a greater range of body types.
Because of the bigger, more powerful design, the stair lift offers availability and enhances movement for anyone who's heavier than average. Nevertheless, the common stair lift might be too narrow or too short for some, and as the sturdy design provides a larger, greater seat, it even more accommodates anyone who's taller than average or has trouble comfortably using a basic model.
While not had to satisfy ADA requirements, stair lifts supply an added benefit to those with movement issues.
Within River Falls a home, a standard lift might accommodate 2 average-sized adults, however what about when you have to handle the public? Your client base, clients, and patients most likely been available in a range of sizes and shapes, so the sturdy model essentially fits everyone who would have to use the stairs.
Exactly what occurs, however, when multiple member of the family need ease of access? Whether you're meeting a current need or expecting a future one, installing a bigger lift takes everyone's physical requirements into consideration. If your home's geared up with adequate area, take preventative measures by having a heavy-duty lift set up.


Modern designer Large Metal Art Crystal Wall Clock.Fashion for home living room decoration. There are many other styles in our company.
Modern crystal rhinestone branch flower large wall clock. Fashion for home living room decoration.


Please see our adoption page for animals that are available. Pluto is our longest resident. He is a 3 year old Staffie cross who loves people and is fine with children. Pluto will fit into a home where someone can be around for a lot of the time, & he will possibly benefit from attending some training classes to brush up on his obedience skills.
When adopting one of our animals you will be required to meet/collect your dog from our kennels. We are always available for advice for the lifetime of the rescued animal.


Tagged depression, mental health, mental health support, Portland, Portlandia, solo adventures, suicide, suicide awareness, travel, travel blogger.
Reblogged this on All Kinds Of Crazy.
Thanks missus 💋 Love ya!
Stunning piece of writing Jenny.


Greenville Titans will have their Last Chance combine this Sunday, April 7 from 1p.m. to 4p.m. at their indoor facility and offices in D1 Sports Training at 1334 Miller Rd., Greenville 29607. Cost is $20. Bring tennis shoes, cleats, and workout clothes. You will get a tee **** All positions welcome.
Athletes who have participated in our program have received offers this year from Florida A&M, Newberry, Carson Newman, and Arkansas Baptist Central.


Aiming to be unique against other event planning companies by providing updated technology and services that guarantee a successful event. Redhead Production organises every event with our client's requirements as the very top priority.
Providing services for filming and editing, moving images and 3D pictures. We can conceive and produce contemporary communications transforming our ideas combined with yours into genius unique content. We have the equipment to produce promotional films, animations, and photography for a variety of media platforms including the web, broadcast, live events and cinema.
Offering broad amounts of knowledge and experience, we can advise you on achievable, affordable productions available within your campaign. The Redhead team has a vast understanding on what the video production process includes.
At the outset, we produce a critical path document, detailing all areas of the project with key action dates and update this regularly throughout preproduction guaranteeing all deliverables are proceeding to plan.
Whilst the critical path typically details all those activities that are required prior to the event, our on-site schedule identifies responsibilities, times and actions for every stage of the event once the project team are on-site.
In addition to the on-site schedule, we produce a conference running order for the benefit of presenters and show crew which provides a minute by minute run-down of the conference itself. Walk-in music, presenters, video inserts, lighting and sound cues . This document details who is presenting, how they present and what props or technology are required to support their time on stage.
Speaker rehearsal schedules – on and off-site – are produced to ensure presenters have ample opportunity to rehearse their presentation content and familiarise themselves with the stage environment and the supporting technology.
Delivery of the event, on the day evaluation plus post event analysis and reconciliation of event.
You get one chance to get it right on the day and we use every tool at our disposal to ensure we do just that.