Congratulations America! You're becoming yet another nation on the socialised medical bandwagon, along with lucky Brits like myself! Thanks to a semantical ploy that only statist fiction could ever consider logical, the Supreme Court upheld Obamacare as constitutional, on the basis that Americans aren't being forced to buy it because it's a tax. Technically the US constitution doesn't allow the government to penalise Americans for not buying health insurance, but by taxing them the Supreme Court has deemed the Affordable Care Act (Obamacare) constitutional. So you see, Obamacare isn't considered a penalty because it's a tax. Doublethink anyone?
Thus Americans must now sign up for Obamacare if they don't have alternative medical insurance, thanks to a work of subjective legalese that could never pass in any objective sense. But what's worse is that the US government only has the authority for very specific taxation, be it directly (such as income tax) or indirectly (such as VAT). This truly is a sad state of affairs for the America people. The US constitution, once the crowning glory of a pioneering constitutional republic, has become nothing but a token parchment that holds no moral or objective value. Statists everywhere must be rubbing their hands in glee, since the US was once the closest that humanity has ever gotten to a truly free society, based on the unalienable rights of people. Today it's just another land where these rights are reinterpreted as others see fit.
Admittedly there is a lot wrong with US healthcare. But it's a typical story of lobby groups breaking down regulation until this becomes a mere shadow of any initial intent. This is nothing new though, as all societies voting for representatives, while giving lobby groups the chance to bribe politicians into compliance, is never going to be efficient in the long run. Add to this the donations for those campaigning for office, and representatives are never going to serve anyone but the most powerful special interest groups overall.
In spite what those on the left might tell you, it's not just corporations that hold sway in this respect. Labour unions like the Service Employees International Union, and feminist lobby groups like the National Organisation for Women, are also very influential. Sure, the obvious culprits like financial institutions and oil companies are always in the mix, and of course there's drug industry lobbyists, highly relevant to the present topic.
Drug industry lobbyists have been pushing for medical prices to remain higher in the wake of Obamacare, a consistent lobbying pattern that leads to anything but a free market of supply and demand. What this does lead to is exploitable red tape in the terms and conditions of policies. Obamacare will purportedly rectify this, though all this regulation will inevitably lead to artificial price fixing, with only slightly less complexity in the terminology that sets out in policies. Obamacare simply prevents a free market of competition between insurance companies from ensuing, contributing to a crony capitalist society.
The slippery slope of inefficiency, leading to a gradual socialisation of the healthcare system, seems unavoidable now in the US – it's only a matter of time. But what would this result in? For starters you can expect more and more cronyism to be adopted. One such example would be cleaning contracts for hospitals. In the UK this is notoriously bad. Contracts are sold to the lowest bidder in a tender offer, over extended periods of several years. The company that wins the contract, often having made the lowest offer, will cut corners in order to make a profit, with disastrous effect. Recently there's been an outbreak of legionnaires disease in an Edinburgh hospital, linked to a contaminated water supply. To date one person has died, and several were put in intensive care.
Legionnaires aside, in the UK there's also the outbreak of MRSA that resurfaces from time to time, again strongly associated with lack of hospital hygiene. UK Hospital waiting times are also a serious issue, up to 7699 people waiting over 36 weeks in Wales, where I live in the UK. These statistics are often worse than they're made out to be, partly because there's a low, medium, and high priority system when being referred to a hospital. Of course, when the pressure on waiting lists is up, the definition of 'priority' is re-evaluated.
Speaking from personal experience I have very little to say that's positive about public healthcare. My father suddenly dropped dead of a heart attack two years ago, and though he was blatantly overweight, his doctor basically allowed him to self-diagnose for years as a sufferer of heartburn, playing along with this absurd suggestion, no doubt because it meant one less person on a hospital waiting list. I would regularly say to my father that he was overweight, but others humoured his delusions, including professionals. As an overweight man my father had to take responsibility for not being here today. Nonetheless, in a private healthcare system medical check-ups are far more readily available, since there's no pressure on quality of service, and doctors can be safe rather than sorry when diagnosing a patient.
My wife also had a tough time when giving birth to our daughter. We were told on the week of Christmas that our daughter had situs inversus, or in other words that the organs in the body are reversed. On New Years Eve it turned out that the nurses doing the ultrasound scan, which doctors do in the US, most likely had the machine aligned incorrectly, therefore mirroring the organs of the body. The moral of the story? Don't send a nurse to do a doctor's job!
During labour, my wife was hoping to have a water birth, but this was abandoned when the running water became discoloured (*cough* legionnaires). She went through around ten hours of labour, only to be told that the baby was back-to-back with the mother, which makes it impossible to push the baby out. She then had to have an episiotomy (look it up - it's not nice).
As a result my wife then spent several days in a dirty ward, where even a second pillow was considered a big ask. My newborn daughter, having contracted jaundice, was struggling to stay awake long enough to feed, while my wife, having never had a child, was simply left to her own devices, unaware that she had to practically force our daughter to stay awake just so she could drink enough milk. All the while the severity of my wife's stitches made it difficult for her to move. I was only allowed to be around this particular ward at certain times of day, which meant my support for her was limited until she got home a few days later.
This mirrors a lot of the things I've experienced in the Canadian health care system. It saddens me that people in the US (and across the world) seem to think that socialised medicine is the only way to go. It makes me wonder if they've ever had to struggle though the hell that is a public healthcare system.
The other side of the situation that I think you may not have considered is that because a public system is price fixed, there's no profit motive for doctors to do things well or right, or even to do things at all. Canada has been suffering under what we call the "Medical Brain Drain" in which our universities are pumping out doctors and nurses like crazy, but our healthcare system has to keep importing doctors from India and China and nurses from the Philippines, because the Canadian doctors and nurses are all going to the States where they can (or could?) make a decent wage (or one that can justify the costs associated with getting a medical degree in Canada).
When will people learn that relying on the government for anything, particularly something as vital as one's health, is folly?
Yes, the UK is importing a lot of doctors too, and the ones that are training here end up with exorbitant debts from university fees, and find it hard to get a job.
I would love to see you create a breakdown of the Canadian healthcare service. It's important that the fabrication of quality public healthcare is exposed at every juncture.
In answer to your question I don't know when people will learn - if ever. What I do know is that socialised medicine is a terrible service that I wish I could opt out of, get a tax break for doing so, and go private. That's the least that should occur to end this inefficiency. It costs lives at the end of the day, as I've learnt first hand.
I want to temper a few of the things you mentioned. With the canadian waiting time example you gave, people can pay extra money to get a private cataract surgery right away, or they can wait to get the same procedure publicly for 'free'.
Health Insurance companies in the USA have a perverse incentive to basically commit fraud and not provide their service if it ever gets 'expensive'. How would you feel if during wife's child birth, the insurance company said FU, you have reversed organs and we're dropping all coverage!
The US also has a ton of harmful regulation that basically causes the cost of health care to be double for the same service compared to a public healthcare system. The USA already had socialized medicine before obama care, it just wasn't equally distributed. There is also a very large administrative inefficiency in the american system not present the socialized system. The US is NOT the model to look at for private health care.
Also having worked with people from china, a persons origin of education shouldn't be the only basis you judge the quality of their ability. I've worked with very skilled PhDs and immigrants from china with thick accents, someones country of origin shouldn't matter, only their skill.
The better private healthcare options often get money from the government for their services, they just charge more and you cover the difference. That is your 'tax break' of sorts. I believe you could of paid extra for a better childbirth experience.
I've worked in the health care industry for the past five years in both billing and as a claims processor. If people think that the treatment they get from private insurance is bad here in the US, it's only going to get worse if the government gets involved. Based on my experience, many providers do not want to become contracted with Medicare because it means only more red tape they have to cut through in order to get reimbursed for their services and reimbursement from Medicare is much less then from a private insurance. If people think that they're going to get "free services," under Obamacare, they're sorely mistaken. Medicare (a federally funded insurance plan) charges patients a copay, coinsurance and or a deductible just like most private insurance plans. The government will have no choice but to bill the individual one, two or all of these options because taxes will not be enough to cover everyone. Therefore it is not a free service.
I do agree that the cost of health care in the US is astronomically high and should be reformed. However our government's plan is not a feasible and will only hurt the people in the end.
ObamaCare is probably the main reason why Obama's party lost the lower house in the 2010 elections. If Romney wins, ObamaCare is toast. Things will get very interesting if the GOP carries the Senate, keeps the House, but Obama is reelected. This is especially true given that Obama does not know how to conciliate and bargain in a back room, over coffee and wine, and finger food. A great deal of practical politics takes place in meetings and over the telephone, where elites call each other by their given names. Kennedy and Johnson were good at this. Nixon, Carter and Obama were not. Obama apparently is an introverted intellectual who likes to give speeches to audiences dominated by the Faithful.
About 40% of USA healthcare spending is public. One accesses this limited public system in one of 3 ways: (1) being past one's 65th birthday; (2) having done time in the US Armed Forces and receiving an honourable discharge; and (3) being deemed indigent. Most people who work for an entity with 100 or more employees enjoy private health insurance for their jobs. Including children and nonworking spouses requires many hundred dollars a month.
If the patient is in crisis, American health care is quite good... and very costly. The wholesale prices of pharmaceuticals in the USA is several times higher than in any other country. The ObamaCare law specifically protects this situation. Most American hospitals were built after 1970. Most of all, all surgeons and most doctors earn enormous annual incomes. I bet USA nurses earn a good deal more than their UK counterparts. Before the rise of banksters, the highest paid people in any USA community were the surgeons.
In the USA, private health insurance is an option. Trouble is, people seek out private insurance only when they suspect that there is something wrong with themselves or with a close family member. Knowing this, private insurers charge more. Private health insurance for a family of 4 now coast about US$1000/month (but comes with some income tax breaks). Most people of average means who believe themselves healthy decline to pay that much. Thus a vicious spiral of rising premiums and worsening average health status of the insured sets in. Economist call this vicious spiral "adverse selection." It is the main reason why affordable health insurance has to be compulsory for all. The NHS in other words. The trouble with the NHS is that it is a monopoly.
What was USA healthcare like before Medicare (1962), Medicaid (1962) and the VA system (1946)? Before the giant "nonprofit" workplace health insurer Blue Cross / Blue Shield (1939)?
The former minarchist regime was made up of doctors and hospitals varying their fees by what the patient was believed to afford. Also, most American cities with a population of 200K or more would have at least one public hospital that would treat without charge those deemed indigent. All doctors did a fair amount of charity work, but led upper middle class lives thanks to the fees they collected from the middle and upper classes. Hospitals were always nonprofits, whose mission statement included an obligation to serve the seriously ill without charge.
Before 1920 or so, the word "doctor" covered a multitude of sins. Some were well trained scientists with 8 years of uni education. Others had attended a shonky trade school for as little as 2 years. The shonkier the qualifications, the lower the fees. Membership in the American Medical Association was voluntary.
In 1910, a layman tabled a report on American medical education, revealing that much of it was inept and shonky. Over the next 20 years, 40-50% of American faculties of medicine closed. The standard of American doctors rose dramatically... but so did their fees.
What great information regarding minarchist health schemes. Thank you for that. I will almost certainly refer to it some time. I have been aware of this sort of system before socialised healthcare before. But solid examples are always very helpful.
It might not necessarily be on topic what I write here but I just had share these thoughts with someone.
So, I was talking with a few socialists about "free" healthcare and education (European style).
They were all claiming that how superior a system is that will allow people to have "free" education and were all on bashing the US and other countries where this is not the case. As if they would be inferior to Europe.
I just could under no circumstance convince them that these things are actually NOT free, not even close.
They were making fun of the US of having student loans while claiming that in Europe you do not have to pay anything at all in order to go to college.
They just don't seem to understand that they actually WILL have to pay for all these things through the exorbitantly high taxes they will pay for the rest of their lives after they get a job. And worse, when the "debt" is paid off, they will STILL have to continue to pay the tax forever.
- student loans: You take the loan, pay for your education yourself. After this, if you are good, you will get a job and pay off your loan. Once you have paid it off, you will not have to continue to pay.
- socialist education: The government will pay for your education (because teachers are obviously not teaching for free). Once you finish your education you will pay back the money the government paid in your place through very high taxes. BUT the taxes will NOT decrease after you have "paid back" your "loan" to the government. You will have to pay the high taxes forever. Even worse, once you get older and will have a better pay, you will have to pay EVEN MORE taxes because of progressive taxation, since supposedly it is not fair that you got "lucky" and earn more and others were "unlucky" and earn less, so you should share your "luck" with others.
I cannot comprehend how people can claim that student loans are "unfair" and "too high" and etc. considering that the cost of "free" socialist education is incomparably higher. It amazes we every day how most people fail to have any kind of common sense at all.
- you have a net salary of $1,700. You will have to pay for your own healthcare insurance, education etc. bringing the money you can use on yourself down to, say, $1,000.
In this case everyone is bitching and moaning that this is not fair and it's theft and capitalism is robbery, since those things should be free and it's not alright that you can only effectively use $1,000 of your earnings.
- you have a net salary of $1,000 (however your employer retains $700 in taxes, insurance etc - so your real salary was $1,700). You get "free" education, healthcare etc.
In this situation, everything becomes suddenly "fair" and alright, even though you still only have $1,000 in your pocket.
Is it REALLY this hard for most people to use some basic logic? Do people only see that money is being taken away from them if they actually hold that money in their hands and have to give it away? Don't they see that in socialism they STILL have to pay for absolutely everything that's supposed to be "free"? And more so, in socialism you pay incomparably more for those kind of services since you will pay the high taxes that are needed for those services forever.
But just the fact that they don't physically hold that money in their hand they fail to see that they effectively have still paid for all the stuff that is supposedly "free".
This is why I say that socialism is the most successful scam in history. It robs people of their money without them even knowing about it.
Don't Fret Mr.Z, there are some people from even the UK/EU, that understand that there's no such thing as a free lunch.
I mean it's simply an expansion of the principles of entropy applied to money movement in a society.
Socialism is basically a Ponzi Scheme, writ large, with noisy Orwellian screens blaring at people, all the time. I'm not sure that there's much distinction between certain kinds of Big Business/Government and Big Brother to be completely honest.
I'm sorry to see that the US is being dragged down this route away from the Republic it was once so proud to be.
Did not Kissenger warn people of the dangers of the military industrial complex and its' ability to lobby government and combine with it, lobbying is another huge issue.
I mean it's as a simple a this: Money/Credits represent the cost, to mine, make, move and use something, and that has to be paid for.
Star Trek (I know not everyones cup if Tea) seems to be a strange utopian world, a sort of scientism/humanist state, with courts governments etc, but a one world culture.
It can easily be read as a Communism of sorts, but it seems to fall down on several counts, namely being democratic.
Babylon 5 is also good for these kind of arguments, as this often appeals to socialist people, it is a mess of situation, but more realistic.
Pop Culture metaphors tend to help, I've noticed, in helping people gain some objectivity about what they think.


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Fox News Announces Major Kayleigh McEnany News
(Photo by OLIVIER DOULIERY/AFP via Getty Images)
Nicole Silverio Media Reporter
December 01, 2022 1:42 PM ET
The panel of Fox News' "Outnumbered" announced Thursday that co-host and former White House press secretary Kayleigh McEnany has given birth to her second child.
McEnany delivered her baby boy, Nash Gilmartin, on Tuesday, making her a mother of two children. She is also the mother to a 3-year-old girl, Blake. Her fellow co-hosts glowingly celebrated the former press secretary's big news.
In response to the birth, "Outnumbered" co-host Emily Compagno cited the Biblical passage from James 1:17, which says, "every good and perfect gift from above, coming down from the Father of the Heavenly lights." The segment showed a photograph of McEnany holding baby Nash and kissing his forehead, and her husband, Sean Gilmartin, kissing hers. (RELATED: Kayleigh McEnany Says Psaki Should Cry About Aborted Children Instead Of Florida's Parental Rights Bill)
A separate photograph showed Blake sitting criss-crossed on the floor with her new brother.
McEnany announced on the program in June that she was four months pregnant. She revealed her child's gender in July during a gender reveal party on the show, and cited the Old Testament's Book of Jeremiah that states, "Before I formed you in the womb, I knew you."
"It stuck in my head this morning that before this beautiful baby was woven together in my stomach, God knew he was a boy and had a plan for his life, a purpose for his life and it's just really neat to watch this play out in the pregnancy," McEnany said in July.
Tags : baby kayleigh mcenany motherhood outnumbered
Nicole Silverio
Follow Nicole Silverio on Twitter @NicoleMSilverio

redpajama_set_name: RedPajamaCommonCrawl


text:
WV-Made
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Subscribe to WV Living
October 20, 2017by Zack HaroldNo CommentsDiscover, Fall 2017
Lost Creek Farm raises the profile of Appalachian cuisine through great meals and compelling stories.
Mike Costello originally planned to go to culinary school. But, after he got a job at a high-end restaurant and saw the demanding schedules and crushing stress, he decided instead to go to journalism school at West Virginia University.
He eventually found a way to combine his interests in food and story with Lost Creek Farm, a traveling kitchen he runs with his wife, Amy. They serve up six-course dinners at venues around West Virginia and its neighboring states, while also telling the stories behind the ingredients and dishes they serve.
On any given night, Costello might tell diners the tale of Logan County's famous Mortgage Lifter tomato, or the sausage made by Harrison County's all-but-forgotten Spanish immigrant community, or his grandmother's communion bread.
There's also an agricultural component to Lost Creek Farm. The couple grows heritage vegetables and raises rabbits, bees, laying hens, and cows. They already use some of those groceries for their dinners but plan to ramp up production even more in coming years.
As Appalachian cuisine gains popularity nationwide, Costello says it's time for West Virginia to realize its value. He's happy to help. "Through food, we're ambassadors for the state," he says. "Appalachian food tradition is so full of stories people can be proud of."
Written by Zack Harold
Zack Harold is a southern West Virginia native. He covered education, health, and government at the Charleston Daily Mail before becoming the newspaper's features editor. He joined New South Media in 2015, became managing editor of WV Living in January 2016, and took over as managing editor of Wonderful West Virginia in July 2016.
Lights, Camera, Action
Five Family-Friendly Fairs and Festivals
Treading New Ground
Fall 2019 on Sale Now
Copyright 2019 New South Media Inc.
<# print( 'WV Living Magazine' ) #>


text:
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redpajama_set_name: RedPajamaGithub


In a few days, September 27 the refresher training course "MANUFACTURING THE PROTOTYPE", organised by Formodena, will start in the headquarters of Carpi Fashion System, via Marx 131/a. The 70 hour course, is part of the extensive training programme of CFS.
The first day of the course is intended to explain to the students that in the world of fashion, the products are good good if the prototype from which they originated is excellent, so their chance of success is due for the 90% to a good prototype.
This is enough to stress the importance of acquiring the necessary technique for the realization of the prototype.
The course, which kicks off Tuesday, September 27, has had a number of previous editions that have obtained a positive outcome among the participants.


From left, municipal Judge Marilyn Rodgers, Oak Ridge North council members Bill Neill and John Planchard, Secretary Sandy Coleman, Mayor Fred Wagner and Council Member Tom Coale celebrate an earlier city anniversary.
Former Mayor Fred Wagner (right) accepts a city seal carved from wood from a tree within the city by resident Tom Bingham (left).
Oak Ridge North has faced its share of change and development over the years, but its leaders, including Mayor Jim Kuykendall, believe the roughly 900-acre municipality still holds true to its small-town ideals while planning ahead for growth.
The city was incorporated Jan. 20, 1979, around five years after neighboring Shenandoah did the same. The borders of Houston were also expanding north at the time, said John Planchard, a founding alderman and Oak Ridge North's third mayor.
Planchard said he recalled a feeling of excitement in the city after its establishment. Six people ran for mayor, and many more ran for one of five alderman spots. A town marshal was also elected, and a secretary was hired, filling out the first administration.
Highlights over the years included the city taking over public works services from the Oak Ridge Municipal Utility District, creating its own police department, adoption of a city administrator—and later, city manager—form of government, setting the city sales tax and the adoption of a long-term comprehensive plan, Planchard said.
The city's population has grown slightly since its founding, but the most notable changes have come from booming development in the area and across I-45.
Oak Ridge North's population grew from less than 2,500 residents in 1980 to more than 3,000 by 2010, according to the U.S. Census Bureau.
Kuykendall said the arrival of new businesses has helped the city, while at the same time, growth has created new planning challenges, such as the ongoing effort to realign Robinson Road as well as challenges in maintaining the city's culture.
Kuykendall said the city's appeal has remained in its welcoming atmosphere, security and ability to plan ahead.


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The third edition of the International Medical Guide for Ships shows designated first-aid providers how to diagnose, treat, and prevent health problems of seafarers on board ship.
The International Labour Organization's Maritime Labour Convention 2006 stipulates that all ships shall carry a medicine chest, medical equipment and a medical guide. The International Medical Guide for Ships supports a main principal of that convention; to ensure that seafarers are given health protection and medical care as comparable as possible to that which is generally available to workers ashore.


-Performing a complimentary inspection each time you bring your car in for an Oil Change!
-Peace of mind by obtaining your permission before we do any work on your car!
-Using only high quality parts that suite your car!
-Providing advice about car maintenance or repair and scheduling your next service!


There is very little political pluralism in Serbia and it keeps declining, the experts warn.
The experts and most of the opposition in Serbia are criticizing the marketing move of the Serbian Progressive Party (SNS), which bought Thursday covers of all but two daily newspapers to promote their presidential candidate only a day before the pre-election silence.
According to the critics, this proves that political pluralism in Serbia barely exists since other presidential candidates cannot afford even a small portion of marketing that the current Prime Minister and presidential candidate Aleksandat Vucic has.
The pre-election silence in Serbia starts on Thursday at midnight. Serbian presidential elections will be held on Sunday, and the citizens will vote from 7 a.m. to 8 p.m.
"Neither the laws nor the codex of journalism is broken by this act of the ruling coalition. However, this is clearly a monopolization of media space. When you come to the newsstand and see that all the newspaper covers look the same, that means that someone took over their brand and used them for the purposes of political campaign," the member of the Press Council, Tamara Skrozza, told Insajder.net.
She said that this situation was probably unimaginable to the writers of ethical codes and laws, so there are no regulations to sanction this.
"I presume no one could imagine that someone would buy the covers of all newspapers in Serbia. I do hope that someone will have this in mind when a new law is drafted since this is an embarrassment for the state and for the profession," said Skrozza.
There is only one presidential candidate, the PM Vucic, who has the funds for serious political marketing, claims the Director of Belgrade based Center for Democracy and Free Elections (CESID), Bojan Klacar.
"Only the PM Vucic has the funds for a serious political campaign and marketing while others can only rely on the field work and direct communication with the voters. This act of buying all the covers of newspapers in Serbia requires serious funding," he told Insajder.
The Serbian Anti-Corruption Agency, which controls the financing of political campaigns, will be left with only 2 members of the Board on 8th April when the mandates of other 4 members expire. The Agency has still not elected its director.


text:
The 2019–20 Louisville Cardinals women's basketball team represented the University of Louisville during the 2019–20 NCAA Division I women's basketball season. The Cardinals, were led by 13th-year head coach Jeff Walz, and played their home games at the KFC Yum! Center in their sixth year in the Atlantic Coast Conference.

The Cardinals finished the season 28–4 and 16–2 in ACC play.  They finished as the regular season ACC champions and earned the first seed in the ACC tournament.  They defeated Syracuse in the Quarterfinals before losing to eventual champions NC State in the Semifinals.  The NCAA tournament was cancelled due to the COVID-19 outbreak.

Previous season
The Cardinals finished the 2018–19 season at 32–4, 14–2 in ACC play to finish in a tie for first place. They advanced to the championship game of the ACC women's tournament where they lost to Notre Dame. They received an at-large for the NCAA women's tournament as a number one seed in the Albany Region. In the tournament, they defeated Robert Morris and Michigan in the first and second rounds, Oregon State in the sweet sixteen before losing to Connecticut in the elite eight.

Off-season

Recruiting Class

Source:

Roster

Rankings

Coaches did not release a Week 2 poll and AP does not release a final poll.  Due to the cancellation of the NCAA Tournament, the coaches poll did not release a final ranking.

Schedule and results

Source

|-
!colspan=9 style=| Exhibition

|-
!colspan=9 style=| Regular season

|-
!colspan=9 style=| ACC Women's Tournament

References

Louisville Cardinals women's basketball seasons
Louisville
Louisville Cardinals women's basketball, 2019-20
Louisville Cardinals women's basketball, 2019-20

redpajama_set_name: RedPajamaWikipedia


Did I see that the information from Active911 can be exported to NFIRS software? Does Firehouse Software accept the information?
Our Department would be intererested in Active 911 export capabilities also, welcome any more info and glad to participate in discussion - thanks!


Riverheads swept past Stonewall Jackson 9-0.
GREENVILLE – Riverheads swept past Stonewall Jackson 9-0 on Tuesday in a girls' tennis match.
Recording singles wins for the Gladiators were Grace Staton, Kaiti Sheaves, Lauren Ernst, Amanda Reese, Kayla Shrader and Abby Cassell. Reese won her match on an 8-0 shutout.
Combining for doubles wins were Sheaves-Shrader, Ernst-Reese and Emily Gardner and Olivia Harris.
Riverheads again takes on Stonewall Jackson on Wednesday at the New Market courts.


text:
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The International Panel on Exiting Violence present its results at the Issam Fares Institute for Public Policy and International Affairs (IFI) at the American University of Beirut (AUB), Lebanon.
3 days of conferences and meetings
DATE DE MISE A JOUR : 20/06/2018
The increasing power of military weapons, combined with aerial surveillance, satellites, sensors and long-distance global communications, has dispersed the military battlefield. Resource-poor forces have responded, first with guerrilla tactics against isolated bases and supply lines; and then with terrorist tactics, hiding in the civilian population and attacking civilians as softer targets. Terrorism grows in symbiosis with high tech weapons and communications because the weaker side cannot win on conventional battlefields.
At the heart of a therapeutic process lies the temporality of healing, an expectation of, at least, a minimum of measurable improvement. What if, however, the trajectory of a life, or suffering, fail to move along this anticipation of a cure? Chronic pain, terminal, and life-long illnesses are part of a spectrum that challenges conventional medicine.
Scientific platforms
Project building
Foundation reward
FMSH Editions
Missions & strategy


text:
About University of Limerick (UL)
The University of Limerick (UL), is located on the west coast of Ireland along the picturesque River Shannon and enjoys an unspoiled natural environment blended with state-of-the-art teaching and research facilities.
UL was awarded prestigious 5-star rankings for graduate employability, innovation and knowledge transfer, teaching, engagement, internationalisation and infrastructure by QS Stars independent assessors.
With close to 12,000 students, including more than 2,000 international students each year, UL is a young and enterprising university with a proud record of innovation in education and scholarship. A survey of Irish students recently voted UL Ireland's most popular university with a satisfaction rating of 85%.
UL offers more than 70 undergraduate programmes across Arts, Humanities and Social Sciences; Education and Health Sciences, Science and Engineering and the Kemmy Business School. UL also delivers a strong postgraduate offering with more than 100 taught postgraduate programmes to Doctoral and Post-doctoral level.
UL pioneered the concept of Cooperative Education in Ireland, placing more than 2,000 students in paid and semi-paid work placements annually - 30% of these as international placements. These valuable work experiences make UL graduates more employable, which is why the UL graduate employment rate is 15% higher than the national average.
With strong links to business and industry, UL excels at translational research which aims to accelerate the practical application of academic research to benefit society. UL houses some of the most innovative and successful research centres in Ireland. The Nexus Innovation Centre is a growing community of international researchers and entrepreneurs which supports new businesses and the creation of jobs.
Known as 'Ireland's Sporting Campus', UL boasts Ireland's first altitude training centre, an Olympic-sized swimming pool and the National Strength and Conditioning Centre. The new 3G pitches are the largest artificial grass development in Europe and the Sports Arena attracts more than 600,000 visitors each year.
Cafes, restaurants, student and faculty accommodation options and a range of on-campus facilities provide an outstanding student experience and a stimulating working environment.


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Ruby Data Structures 101: Arrays and Hashes

June 28, 2015

Handling collections of data efficiently is one of the most important things any general-purpose programming language should be able to do. Whether the collection of data is small or large, leveraging the power of a computer to process it sure beats doing everything by hand. Different programming languages provide different (though generally similar) tools for structuring data. Ruby gives its users two powerful built-in data structures for handling collections of data: arrays and hashes. This post presents a basic overview of both structures and examples of their proper use. Also, there will be two atrocious, cringe-worthy puns. You've been warned.

Array of Hope

Arrays in Ruby are used to represent any collection of objects, and in particular, any collection whose order is important. Let's say Bobby's pre-algebra teacher wants to store his five test grades for storage and computational purposes. Hopefully for Bobby's sake, his grades will look something like this:

bobby_grades = [99, 94, 100, 97, 98]

Now if Bobby's teacher wants to quickly access his star pupil's grade on the first test, it's as simple as typing:

bobby_grades[0]
# Result: 99
# (As in many programming languages, counting in Ruby starts from 0.)

And if the teacher wants to find Bobby's average grade, something like this would accomplish it:

bobby_grades.inject(0) { |sum, grade| sum + grade}.fdiv(bobby_grades.length)
# Result: 97.6

While this particular example of an array used a collection of integers, arrays in Ruby can take a collection of any type of object (strings, booleans, classes, other arrays) and even mix object type (though this is not usually recommended).

Making a Hash of It

In contrast to arrays, hashes in Ruby store pairs of data, and each pair consists of a key and value. A dictionary is a classic example of a situation where a hash should be utilized:

devils_dictionary = {
  "learning" => "The kind of ignorance distinguishing the studious",
  "Mammon" => "The god of the world's leading religion"}

Or say you're designing a video game and you want to assign attributes to your childhood hockey hero:

joe_sakic = {"skating" => 95, "passing" => 97, "wrist_shot" => 99, "hair" => 72}

With hashes, retrieving a stored value is done by referencing its key:

joe_sakic["hair"]
# Result: 72

In versions of Ruby up to and including 1.8.x, hashes were unordered collections, which represented another crucial distinction from arrays. In practice though, since values in hashes are generally accessed by their keys and not by a numerical index (as elements in arrays are), it's still feasible to think of arrays as more explicitly and obviously ordered than hashes.

Summary

Use arrays for a collection of objects; use hashes for a collection of object pairs. Or, to give one final example:

Array

bad_puns = ["Array of hope", "Make a hash of it"]

Hash

lameness_level = {"Array of hope" => 99, "Make a hash of it" => 92}

Onwards and upwards, fellow Rubyists!

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text:
< Virginia Konchan welcomes you to her harem
Persona, a newly-released English translation of Yukio Mishima's biography. >
The difference between a concept & a constraint, part 1: What is a concept?
Posted by A D Jameson @ 8:01 am on February 25th, 2013
Sol LeWitt: "Wall Drawing #1111: A Circle with Broken Bands of Color" (2003, detail). Photo by Jason Stec.
[Update: Part 2 is here.]
I wrote about this to some extent here, but I wanted to expound on the issue in what I hope is a more coherent form. Because I frequently see concepts confused with constraints, and the Oulipo lumped in with conceptual writing. For instance, this entry at Poets.org, "A Brief Guide to Conceptual Poetry," states:
One direct predecessor of contemporary conceptual writing is Oulipo (l'Ouvroir de Littérature Potentielle), a writers' group interested in experimenting with different forms of literary constraint, represented by writers like Italo Calvino, Georges Perec, and Raymound Queneau. One example of an Oulipean constraint is the N + 7 procedure, in which each word in an original text is replaced with the word which appears seven entries below it in a dictionary. Other key influences cited include John Cage's and Jackson Mac Low's chance operations, as well as the Brazilian concrete poetry movement.
I would argue that the Oulipo, historically speaking, are not conceptual writers/artists—although it's easy to see how that confusion has come about, because the Oulipians have proposed some conceptual techniques, such as N+7 (which I'd argue is not a constraint). (Also, it's each noun that gets replaced, not each word.)
What, then, distinguishes concepts from constraints? And why does that distinction matter? In this series of posts, I'll try answering those questions, starting with what we mean when we call art conceptual.
Today's conceptual writing largely springs from the conceptual art of the late 1960s. When Kenneth Goldsmith says he desires a thinkership, not a readership, or that one of the books he's written doesn't have to be read—
The best thing about conceptual poetry is that it doesn't need to be read. You don't have to read it. As a matter of fact, you can write books, and you don't even have to read them. My books, for example, are unreadable. All you need to know is the concept behind them.
—he's drawing on notions advanced by the conceptual artist Sol LeWitt (1928–2007). LeWitt most clearly defined conceptual art in two seminal essays: "Paragraphs on Conceptual Art" (1967) and "Sentences on Conceptual Art" (1969). Nothing should stop you from reading those essays right now. (They're both very short.)
LeWitt was quite serious when he wrote in "Paragraphs," "The idea becomes a machine that makes the art," the line that's become the mantra of conceptual art. Basically, a conceptual artist comes up with an idea (a concept), which is itself the artwork. The artist (or another person) may then execute the concept. If so, the work produced counts as a demonstration of the originating idea. But it isn't the artwork per se; it's more like a record or product of the execution.
Along these lines, LeWitt sold not drawings, but sets of instructions for making drawings. When a museum or gallery purchased one of his pieces, they got a sheet of paper telling them what to do. (Here's an example of one.) They also got the right to execute those instructions, to display the results, and to eventually stop displaying those results (by destroying the drawing). Here, for instance, is a 2010 blog post about the 2010 installation of LeWitt's Wall Drawing #1111: A Circle with Broken Bands of Color (2003) at the Art Institute of Chicago. Author Katie R. writes:
For those of you unfamiliar with LeWitt's work, much of it doesn't exist like most artworks do, as a tangible painting, drawing, or sculpture. Rather, it is a list of instructions on how to create the artwork. As a conceptual artist, LeWitt believed that it wasn't the finished work that was the "art"; art instead begins and ends with an idea.
(That post includes photos documenting the wall drawing's execution, and there's also an accompanying video. Also, note that LeWitt called these works "drawings" even when they involved paint.)
LeWitt, who died in 2007, of course had nothing to do with the implementation of Wall Drawing #1111. Conceptual art has no problem with this, because one of its tenets is that it doesn't matter who executes the concept. Since any result produced is not the actual artwork, anyone can therefore execute it—provided they have the right to, and provided they follow the instructions (which should be contained in the original concept).
Without getting too sidetracked here, it's important to note that conceptual art emerged during a period in art's history when many considered it important—essential, even—to limit the number of decisions the artist made. As the Poets.org entry claims, John Cage's chance operations were influential. As you may know, Cage routinely used chance operations when composing, trying to remove conscious decisions from the art-making process. Why he and other artists thought this so desirable—and why some artists still consider it paramount today—is a complicated argument that I promise to return to later.
LeWitt didn't use chance operations, but he did devise his own means for removing or limiting conscious decision making. He was adamant on the idea that, once the artist formulated the originating concept, he or she should not to anything to interfere with its execution. As he wrote in "Paragraphs":
When an artist uses a conceptual form of art, it means that all of the planning and decisions are made beforehand and the execution is a perfunctory affair. […]
[…] arbitrary or chance decisions would be kept to a minimum, while caprice, taste and others whimsies would be eliminated from the making of the art.
[…] To work with a plan that is preset is one way of avoiding subjectivity.
[…] the fewer decisions made in the course of completing the work, the better. This eliminates the arbitrary, the capricious, and the subjective as much as possible.
To be sure, executing a LeWitt wall drawing will always involve minor unique decisions—for starters, which wall? The implementation of Wall Drawing #1111 at the Art Institute involved that and other choices, as Katie R. author noted:
The general layout and colors to be used are predetermined. Also, there are certain rules within the piece that we have to follow. For example, no one block of color should ever come into contact with another block of the same color, no yellows touching yellows, etc. It seems as if the exact order of the colors in the circular bands can be open for interpretation. However, I know that Takashi, the draftsman from the LeWitt foundation, brought a schematic with him that we've been following.
I don't know the source of that schematic, or how it was devised. But the important point here is how much conscious decision making has been removed from the execution of the instructions. Ideally, the conceptual artist devises a concept so pure and so clear that its execution eliminates the need for any such decisions. Furthermore, the resulting work, if faithfully executed, should clearly communicate the original idea or concept. That is to say, the work produced should not obscure the underlying concept. (Sol LeWitt's wall drawings are traditionally displayed alongside his page of instructions, as well as some account of who executed the piece, and when.)
LeWitt expounded further on this notion that the author relinquish as much control as possible in "Sentences," where he wrote:
5. Irrational thoughts should be followed absolutely and logically.
6. If the artist changes his mind midway through the execution of the piece he compromises the result and repeats past results.
7. The artist's will is secondary to the process he initiates from idea to completion. His wilfulness may only be ego.
28. Once the idea of the piece is established in the artist's mind and the final form is decided, the process is carried out blindly. There are many side effects that the artist cannot imagine. These may be used as ideas for new works.
29. The process is mechanical and should not be tampered with. It should run its course.
The conceptual artist, therefore, accepts whatever results occur as a result of implementing his or her concept. This is a very important point that really can't be overstated. No changing your mind! No interfering! And this is the essential function of the concept, as well as what was so revolutionary about it. Concepts motivate and control the execution of projects and (ideally) remove any and all need for later decision making.
Kenneth Goldsmith is probably the best known conceptual writer working today, both in the indie lit scene and beyond (he's read his work at the White House, even). Originally trained as a visual artist, Goldsmith derived many of his ideas from LeWitt. For one thing, he agrees with the notion that the artist should accept whatever results occur when executing a concept. In a conversation with Marjorie Perloff, he described how his own art-making improved when he stopped editing his results:
The precursor to No. 111 was a gallery work called No. 109, whereby I used the same method of collecting language as I did for No. 111: any word or phrase ending in the sound of "r" or the "schwa" was permitted. In preparation for the gallery show, I edited the piece down to only contain what I considered the "good" words — the "fun" words, the "entertaining" words, the words that really "zinged." […]
In an introspective moment after the show had ended, I went back and looked at all the words and phrases I had omitted. They seemed to be perfectly good words and leaving them out did not make the piece any more of a popular success. So I incorporated them all into a new work which grew to be No. 111. But even then, many years into the project, I found myself not able to accept just any word or phrase; instead, I took only the phrases that interested me. That's why No. 111 is such a readable book; it tames the wide world of available language and focuses it through the fine lens of one person's experience. In that sense, it's a very organized and sharp collection.
But in the end, I decided that that was only one way to go about a collection […]. Instead of focusing on the text itself, I began to focus on the greater method or the concept instead and let the language fall where it may within that specified context. Hence, no words could be "wrong" or "boring" if I could justify it being there conceptually [sic]. Suddenly, more traditional linguistic concerns of readerliness, rhythm, phrasing, song, etc. were no longer of importance to me and I found that incredibly liberating.
We should find here strong echoes with Cage: Goldsmith's realization that all words are equally good—that none of them are "wrong" or "boring"—recalls Cage's argument that all sounds are equally fine and therefore acceptable when making music. Goldsmith is also adhering to LeWitt's notion that once a concept is set in motion, it should be obeyed without judgment or interference.
Goldsmith's Day (2003) provides an excellent example of a simple concept executed faithfully. Goldsmith decided to transcribe the Friday, 1 September, 2000 edition of the New York Times, "word for word, letter for letter, from the upper left hand corner to the lower right hand corner, page by page." That idea then became the machine that made the art: it set Goldsmith in motion, and he mechanically executed it (literally, as he later abandoned retyping in favor of using a scanner).
Here, then, is the situation we're dealing with. The conceptual artist stands behind the concept, and therefore behind the artwork, and takes care not to interfere with the execution of the artwork:
Artist > Concept > Artwork (Product)
It should be clear now why the Oulipo's N+7 technique can be considered conceptual. In that procedure, each noun in a chosen text is replaced with a noun seven entries down in a dictionary. Obviously it doesn't matter who performs it (although it does matter which dictionary is used). As an example, here's the procedure applied to the second paragraph of Harry Mathews's novel Cigarettes, using the Random House Webster's Dictionary (2nd Edition):
[original, nouns emphasized] The gabled house loomed over us like a buzzard stuffed in mid flight. People were still arriving. Through the lilac hedge came the rustle of gravel smoothly compressed, and swinging streaks of light that flashed beyond us a pale bank of Japanese dogwood, where a man in a white dinner jacket stood inspecting Allan's letter with a penlight.
[after N+7, new nouns emphasized] The gabled househusband loomed over us like a bygone stuffed in mid Flint. Peppermint were still arriving. Through the lilac hegemony came the Rwanda of gravy smoothly compressed, and swinging strength of light meter that flashed beyond us a pale banner of jaundice, where a Manama in a white Dionysus stood inspecting Allan's letup with a Pennsylvania.
I performed this operation by hand, even though there exist now websites that will do it for you automatically (such as this one). And while performing it, I was tempted a couple of times to cheat, substituting "better" words for the ones the procedure generated. For instance, I thought "lightning" more interesting than "light meter," and "manatee" preferable to "Manama." But the procedure calls for obedience, and I could hear Kenneth Goldsmith whispering insistently in my ear that no word is wrong or boring—so I obeyed.
This essential component of conceptual art—non-interference—leads us directly to Goldsmith's argument against most of the other work done by the Oulipo:
One of the greatest problems I have with OULIPO is the lack of interesting production that resulted from it. While I like the idea of "potential literature," it strikes me that their output should have remained conceptual — a mapping, so to speak; judging by the works that have been realized, they might be better left as ideas. On the whole, they embraced a blandly conservative narrative fiction which seems to bury the very interesting procedures that went into creating the works.
Goldsmith's critique will take some unpacking. What does he mean by "the lack of interesting production"? As well as "blandly conservative narrative fiction"? Because these judgments are, I want to argue, directly related to the assumptions and philosophies motivating conceptual art. I'll start there in the follow-up to this post, where I'll look more closely at constraints. [Update: Again, here's Part 2, as promised.]
But for now, we have our first indication of why the Oulipo, and constraint-based writing, is not conceptual art. There's something wrong, Goldsmith is proposing, with how the Oulipians have executed their ideas. (Hint: it has to do with the fact that they edit.)
Ta-ta for now. Until next time, may all your ideas be good ones.
Tags: conceptual art, conceptual writing, constraints, harry mathews, Jason Stec, John Cage, kenneth goldsmith, n+7, oulipo, Sol LeWitt


Canada's History speaks to Tim Cook about his work towards popularizing Canadian military history.
2014 marks the one hundredth anniversary of the beginning of the First World War, which claimed 67,000 Canadians and wounded another 173,000. The event shocked and shaped our burgeoning country and no person or community was left unaffected. Over the past decade, acclaimed historian and author Tim Cook has championed the cause of making military history more accessible, vivid and factual. His best-selling books capture the reader's attention and heart, as he details the struggles and accomplishments of ordinary Canadians in the face of wartime realities.
For this invaluable perspective about Canadians who have significantly contributed to the shaping of our history, Canada's History Society is awarding this year's Governor General's History Award for Popular Media: The Pierre Berton Award to Tim Cook from Ottawa.
As the First World War Historian at the Canadian War Museum, Tim Cook has been project leader in curating six museum exhibitions since the opening in 2005 including the permanent Gallery for the First World War and companion World War I Internet exhibition. He is also the prolific author of six military books and past recipient of the Charles Taylor Prize for non-fiction, the John Dafoe Prize and the Ottawa Book Award. His latest book, Warlords: Borden, Mackenzie King, and Canada's World Wars, was shortlisted for the 2013 Charles A. Taylor Award for Literary Non-fiction.


Staff at the Berner Middle School in Massapequa, NY, help students register for Day Silence. Photo courtesy of Tracey Johnson.
More than 8 out of 10 LGBT students (82%) are harassed at school each year because of their sexual orientation and more than 6 out of 10 (64%) because of their gender expression, according to GLSEN's 2011 National School Climate Survey. More than 31% of LGBT students said they missed at least a day of school in the past month because they felt unsafe. The report also found that students who are more frequently harassed skip school more often, have lower grade point averages, higher rates of depression and lower self-esteem, and are less likely to go on to college. The report shows, however, that students at schools that take action to address anti-LGBT bias and behavior – such as supporting students who participate in GLSEN's Day of Silence – experience less victimization, have better educational outcomes and report better mental health.
Students and schools can register for the event on the GLSEN site and contact the organization to find out about participating schools and students in their area. Buttons, T-shirts, and dowloadable logos are also available.
It seems respect is a one way street. If anyone disagrees with this agenda they are "intolerant", even harassed into being fired from a job. Evidenced by the firing of the CEO, Brendan Eich, of Mozilla-Firefox for contributing to an organization eight years ago. He has a belief that is foreign to this organization and the intolerance of groups your agree with is amazing.


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Home Chronic Lymphocytic Leukemia Treatments
ASH 2017 Roundtable: CLL Research News and Updates From an Expert Panel
Topic Areas: Chronic Lymphocytic Leukemia
Conferences: News From the American Society of Hematology (ASH) 2017 Annual Meeting
Inhibitor Therapies: How Do They Treat CLL?
Expanding Treatment Options for CLL: Session 1 Replay
The Long-Term Use of Ibrutinib for CLL
What's the latest news in CLL coming out from ASH 2017? On location at the 2017 American Society of Hematology (ASH) meeting in Atlanta, Patient Power founder Andrew Schorr hosts an expert roundtable to review CLL news released at the conference and what it could mean for patients. Leading CLL specialists, Dr. William Wierda, Dr. Jennifer Brown and Dr. Anthony Mato, explore emerging research, including new data on CAR T-cell therapies, inhibitor treatments and the role of genetics.
This program is a Patient Empowerment Network program produced by Patient Power. We thank AbbVie, Inc. and Genentech for their support.
Jennifer R. Brown, MD, PhD
William Wierda, MD, PhD
Patient Empowerment Network
Transcript | ASH 2017 Roundtable: CLL Research News and Updates From an Expert Panel
What's the latest in CLL, chronic lymphocytic leukemia, coming from the big convention where all the experts from around the world get together? We're bringing you that right now.
Hello and welcome to this Patient Empowerment Network program. I'm Andrew Schorr. We're on location in Atlantic, Georgia, where more than 25,000 physicians and researchers, a few of us patients have gathered in Atlantic for the American Society of Hematology medical meeting. People come from around the world to discuss the latest, and among the topics they discuss is CLL. I've been living with it for 21 years. Certainly you and your loved one may well be affected by it. You want to hear the latest, so we have some great experts with us to discuss what's coming out of this meeting and how can it inform you and your family so you get the treatment that's right for you.
I want to introduce our expert guests. Joining us is Dr. Anthony Mato from the Abramson Cancer Center at the University of Pennsylvania. You're a director of the CLL program there. Thank you so much for being with us.
Dr. Mato:
Thanks for having me.
And we have Dr. Jennifer Brown from the Dana-Farber Cancer Institute in Boston, and you're the director of the CLL program there. Thank you so much for being with us.
And the same, from MD Anderson, Dr. William Wierda joins us once again, and he is the section head for CLL there and also Medical Director?
Dr. Wierda:
Yes, Medical Director.
Department of Leukemia. Thank you so much. All right. Let's start with you, Bill, a headline from this meeting that's meaningful for patients and families affected by CLL.
So the big trial that's going to be presented, and it's going to be presented as a late breaker is the MURANO Study which is a trial with venetoclax (Venclexta)/rituximab (Rituxan) versus bendamustine (Treanda)/rituximab for previously treated patients with CLL. And that's a positive trial, meaning the patients who receive the venetoclax/rituximab arm did much better in terms of their length of remission and response to treatment than patients who got what was considered at the time of the trial was designed, the standard of bendamustine/rituximab.
So that's—that is probably the most important trial and data that we're hearing about that directly affects patients in the short term at this meeting. And for me that trial is very important because it heralds the era of moving out of chemotherapy-based treatment and more into the small molecule inhibitor nonchemotherapy strategy.
So just so people understand rituximab, which I have had, is an infused therapy although I think—have they come out with an injectable one too?
There's a subcutaneous formula.
So that's improving, and then an oral therapy, venetoclax.
Jennifer Brown, how about you? What's impressing you for this meeting for CLL patients?
Dr. Brown:
Well, I certainly agree with Bill that the venetoclax/rituximab combination, which will probably get approved in the next six months or so, will represent a great new option for patients in relapse. There's another what we call registration trial that's reading out, which will be less impactful in the short term but may lead to another option, and that's the DUO Trial, which paired a new PI3 kinase inhibitor. This is a type of oral inhibitor, targeted drug similar to ibrutinib or venetoclax but a different pathway, to ofatumumab (Arzerra). And that also found a quite significant benefit in the duration of disease control among relapsed/refractory CLL patients.
So we're looking at how long can the therapy work. In other words, how big a bang do you get for it for how long?
And how about you, Dr. Mato?
I would say a decade ago people in the CLL community were asking for more tools, more agents for treating patients. Things have changed radically, and by this ASH meeting I think the headline is we have many active drugs, and over and over again we're seeing now how oncologists are learning how to combine those drugs differently. And so I feel like one of the themes of the meeting is several presentations looking at how to incorporate novel agents into standard regimens, how to use them as a backbone to integrate other new agents, and then really begging the question, and I think this will be for future meetings, how do we decide which of these combinations are the right ones to move forward for our practices?
Let's start first though with an individual oral therapy. I believe you've had a presentation on ibrutinib (Imbruvica). So we've had that for a couple years now, a few years. Many people are taking it. How is it working? It doesn't work for everybody, I know, and some people have cardio issues and maybe some other issues, so how—what's the latest?
So we have a presentation looking at the experience of patients treated with ibrutinib in clinical practice, and we put together a series of 391 patients who were treated mostly at academic medical centers, but there were actually some community practices that participated there asking the question are the experiences from clinical trials translated to our patients when they're receiving ibrutinib? So we started to ask questions like what are the discontinuation rates, what are the toxicities that we're observing, are they different than what was reported in the clinical trial?
Real-world story.
I mean that's the term that's been coined, but I feel like it's the clinical practice, the nonclinical trial story of some of the novel agents. And what we're learning is that the outcomes from patients are excellent with ibrutinib in our practices, although there are some differences in the way the drug is being dosed, there's some difference in the toxicity profiles we're seeing, and I think the presentation itself serves as an opportunity for education as to how we can even further optimize the use of that agent.
Jennifer, what about options for people where ibrutinib is not working, or they can't stay on it? How do you feel about what you can offer people either in a trial or other medicines that are being approved or maybe have been approved for something else?
Well, we certainly do have a lot of options. Usually I first try to work with people to see if we can manage the problem and issues that they're having, sometimes with a lower dose, sometimes with a short break. Sometimes we can, but if that doesn't work, we have next-generation BTK inhibitors that are coming along that seem to have a reduction in some of the side effects, although the data are still a little bit limited compared to the data that we have with ibrutinib, so we'll need to follow that. But certainly in my experience I have had fewer patients with, for example, the cardiac problems with some of these newer generation BTK inhibitors.
We also have newer generation BTK inhibitors that work against people whose diseases progressed on ibrutinib, which is a whole new class of drugs that are coming into the fore that will be very beneficial for people for whom ibrutinib...
…so like a second line, because ibrutinib can be used I think now, first line, right?
So now you're saying if you have someone where it's just not paying off for them you will have something else.
Still within the same family even, without even moving on to the next family, which is usually the venetoclax family or the Bcl-2 family. We have good data for the effectiveness of venetoclax after ibrutinib.
But we've mentioned a couple of novel agents as you call them, oral therapies, ibrutinib and venetoclax.
Bill, you've had trials, and I think maybe at the other centers as well looking at the two drugs together. So what's the rationale for that? Do they go after the cancer cells in different ways?
So they kill leukemia cells by different mechanisms, and so—and there's laboratory data that shows that and confirms that and we're looking at that in patients now. The other aspect of combining things is that they don't have the same toxicity profile, so they're easier to put together, because you don't worry about making something much worse than it was with either drug by itself.
So we have a trial that one of our faculty members presented which was a combination of ibrutinib and venetoclax for previously treated patients and for previously untreated patients. And the purpose of that study is to give patients a defined treatment period, a defined treatment course with expectation that they will have a very deep remission at the end of that period, and that would mean that they could stop treatment and have a treatment-free period, and hopefully that would be many years like we see with chemoimmunotherapy in many cases particularly in patients who are receiving their first treatment.
So the strategy is to get a good, deep remission initially with a defined treatment period. We're looking at MRD at the end of that treatment.
Minimal residual disease.
Minimal residual disease—and to be able to stop the treatment and give them a treatment?free, treatment-free period. So we're seeing very promising results. We reported early results from that trial, and we're seeing a high percentage of patients who are achieving deep minimal residual disease-free remissions.
And this trial or variations of it with two drugs will be at many centers?
This trial is an MD Anderson trial. We've actually finished enrollment to the untreated patient cohort. We have plenty of clots on the—for the previously treated patients, but we've quickly filled the untreated patient cohort. There are other trials like this that are ongoing. There's a trial that's being done and sponsored by Pharmacyclics that's still enrolling patients. In the UK, there's a very large study that they're opening in untreated patients with a similar combination. So others—and then the German CLL Study Group has a large trial with multiple arms of similar combinations, so combinations of venetoclax plus a CD20 antibody or a three-drug combination with ibrutinib, venetoclax and a CD20 antibody. So we're studying the two small molecule oral agents, ibrutinib, venetoclax together, and other groups are studying that combination with a CD20 antibody in addition.
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Co-op opens 3rd On The Go store with first-ever coffee counter
The new Co-op Baker Street follows a £2.1m investment to support up to 50 jobs in the local community.
// Co-op opens third On The Go store at Baker Street, central London
// The grab-and-go concept also has the Co-op's first-ever Ever Ground Coffee counter
The Co-op has opened a new-look convenience store in central London that showcases the retailer's first-ever coffee counter.
The new 2168sq ft store on Baker street is the Co-op's third On The Go convenience concept store, and follows a £2.1 million investment to support up to 50 jobs in the local community.
The store also features the Co-op's own Ever Ground Coffee counter, with the addition of two Ever Ground coffee machines.
Co-op to launch "extensive" recycling scheme in 2300 stores
Co-op launches new pregnancy loss policy
Co-op unveils new climate plan to grow business
The Co-op said its Ever Ground brand is 100 per cent Fairtrade and the counter will additionally sell a range of hot food and in-store bakery items.
"We're really looking forward to bringing the new concept store and coffee counter to Baker Street," Co-op coffee buyer Jenna Thomas said.
"With its fantastic location within the station, we will offer ease, speed, quality and convenience for commuting consumers in the city.
"Fairtrade is central to our core business values and we are delighted to support the scheme in this new concept with our new, full-bodied, great tasting freshly ground coffee, that's grounded in good."
The retailer said "a greater understanding" of its customers is what resulted in the creation of a grab-and-go proposition.
The Baker Street new store will also have a free water refill station, an orange juice machine, frozen drinks and a milkshake machine.
Other treats available include hot food, impulse bakery products, sushi and donuts, as well as sandwich, salads, pasta, snacking, ready meals, wines, chilled drinks and everyday essentials which completes the Co-op's grab-and-go mission.
Jenna Thomas
London retail
Asda welcomes former Tesco executive as retail director
Oxford Street remains Europe's most popular shopping destination
Asda & Co-op bosses made CBEs for food supply chain efforts
New Selfridges owners planning luxury hotel at flagship Oxford Street store
UK spend on ethical products shoots past £100bn for first time
Pret a Manger sees City of London sales plummet 30% amid Omicron wave
Aldi ends Deliveroo partnership to focus on click-and-collect


GENERAL: You will at once, on the receipt of this order, proceed with your command, and report to Major-General Weitzel, commanding Twenty-fifth Army Corps, Army of the James. You will take your baggage, camp and garrison equipage, &c. You will give strict orders to have your camps left unmolested, and as clean as possible, as they will be occupied by the troops relieving you. Regimental commanders will be held personally responsible that this order is complied with.