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> Daniel Z. Chen
Daniel Z. Chen
https://fortex.com/
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Chief Executive Officer and Co-founder
With expertise in a broad range of financial markets and technologies, Daniel is responsible for Fortex's product strategies, execution, operation, and business development. His expertise in high-frequency, low-latency technology and market microstructure makes him a trusted source in the field of quantitative and algorithmic trading. Prior to Fortex, Daniel co-founded and bootstrapped the highly successful Millennium Exchange, an early pioneer in electronic trading technology for equities and options. Millennium Exchange was acquired by an investment syndicate. Daniel started his career at Goldman Sachs in New York, specializing in the areas of trading and principal investment of complex structured products and distressed assets. He also participated in the development of large-scale trading and analytics systems that contributed to Goldman Sachs' competitive trading success. He graduated from New York University with distinguished honors in Computer Science and Economics.
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Q: How to use MySql dataaccess approch using ado.net or entity framework in .net core I am migrating a .net 4.5 project to .net core. In an existing project I have used an enterprise library for data access. As .net core don't have support for an enterprise library, I need data access support for a MYSQL database. Can anyone suggest or provide me solution for achieving this?

A: Coming Soon:
https://docs.efproject.net/en/latest/providers/mysql/index.html?highlight=mysql
If you poke around the forums, there are sever projects that have been started. Personally I'd wait for the official version:
http://forums.mysql.com/read.php?38,646467,647514#msg-647514

redpajama_set_name: RedPajamaStackExchange


Favorite Cut Flower Seeds by Botanical Interests will make beautiful flowers available in your own backyard to create fresh cut arrangements all season long! Choose from several varieties including: Aster, Bachelor's Button, Snapdragon and more! All Favorite Cut Flower Seeds by Botanical Interests are packed for 2019, are untreated and contain no GMOs.


Too Much in Love to Care is Claire Martin's first US studio recording for fifteen years and guest stars Kenny Barron. It was named 'Best New Album' at the 2013 British Jazz Awards.
Claire Martin has been a driving force behind the UK jazz scene for the past 25 years and has won many accolades, including a British Jazz Award no less than six times. Her massive contribution to UK jazz was noted in 2011 when she was the proud recipient of an O.B.E. in the Queen's Birthday Honours List for her services to music.
2011 saw Claire return to the States where she performed sell-out shows at The Lincoln Center with pianist Bill Charlap and The Algonquin Hotel in New York City with Sir Richard Rodney Bennett. New York City was also the location for her latest recording Too Much in Love to Care which she recorded with guest star Kenny Barron at Avatar Studios, one of the greatest recording facilities in the world.
They were joined by bassist Peter Washington, drummer Kenny Washington and guest Steve Wilson on saxophone and flute.
Too Much in Love to Care is a collection of classic romantic songs and beautiful ballads from The Great American Songbook with many of the tracks recorded in just one take, remarkable as it was the first time Claire and Kenny had played together.
This album was named 'Best New Album' at the 2013 British Jazz Awards and 'One of the Best Albums of 2012' by Jazz History Online.
New album from Claire Martin in April.


Manning's Piggly Wiggly is Baldwin County's family-owned grocery store. Our roots go back to the 1970's; and with these deep roots, we gather our strength. We will provide excellent customer service and exceptional value through our cost plus pricing. We strive to provide a safe and ethical workplace for our customers, employees and vendors. We earn the loyalty of the people we serve through honesty, integrity and the passion of our employees. Through teamwork we will first anticipate and then fulfill the needs of our customers. As a locally owned, third generation family business we support charitable organizations and the communities in which our employees and customers live. We reinvest in the communities we serve by purchasing local products whenever possible and by providing employment opportunities.


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How to Go From Veteran Hero to Civilian Employee
When I first started out in career coaching, I worked as the director of a career center at a college located next to the largest military installation in the world. Many of our students were U.S. veteran men and women making the transition from the military to a civilian job.
How to Go From Military Hero to Civilian Employee
When I first started out in career coaching, I worked as the director of a career center at a college located next to the largest military installation in the world. Many of our students were U.S. service men and women earning their degrees on the G.I. Bill and looking to

redpajama_set_name: RedPajamaCommonCrawl


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Jazz band for people with learning disabilities changing lives
A jazz band that gives people with learning disabilities the chance to create, rehearse and perform their own music alongside seasoned players is revolutionising some of its participants' lives.
Band without Boundaries, based in Kent, teams up seasoned musicians with about 8-10 people with learning disabilities to play jazz.
The band was created after Kent Music was challenged by Community Futures Kent to devise a way of offering free, socially inclusive music-making for adults with a range of learning disabilities.
Sue Marlow, Kent Music's development worker for West Kent, said: "My immediate thought was jazz. I was running a jazz group for adults and asked some of them if they would like to be part of it. They are such giving people and so we have a wonderful core of musicians who are learning from the experience too.
"We had our first session in November 2010 and we have had about 20 sessions so far, one a month on average, with funding from Kent County Council and a private sponsor channelled through Community Futures Kent. Now we're looking for more funding to keep Band without Boundaries going into the future."
The band is having a positive effect on participants. "One man, who is 90, has never played before in his life, the whole of which has always been in an institution," says Marlow. "He loves the sessions, really looks forward to it, and is always asking his carers when the next rehearsal is being held.
"Another man with a very restricted past now mixes and speaks to people who have a real interest in him as a person rather than his learning difficulty. The impact on their lives is amazing."
Each Band without Boundaries session is attended by about 20 people, mainly from Sevenoaks, Tonbridge and Swanley. It is a mix of local musicians and 8-10 people with learning disabilities and their support workers.
The sessions are directed by Joe Browne, a former member of Kent Youth Jazz Orchestra and the National Youth Jazz Orchestra who is now a freelance musician and music leader.
While Browne sets up keyboards, and volunteers bring their own wind instruments and guitars, Marlow organises a selection of percussion instruments, including tambourines, shakers, claves, djembes and a full drum kit.
"Percussion instruments are more accessible, particularly for people whose disability may leave them with limited co-ordination," Marlow said.
"A lot of what we play is improvised and devised by us but we also do some well-known material – our version of the James Bond theme has become a bit of a regular. Joe directs the group with gestures and hand signals and everyone looks at him intently, rather than out at the audience."
Browne has adapted his teaching techniques to fit the mix of abilities of the group. He starts with tapping out question-and-answer rhythms, encourages a complementary beat, then the instruments join in. Browne teaches the percussionists that the gaps and stops in music are as important as the notes and that everyone's contribution is important to the final sound.
"Leading the jazz club has been one of the happiest musical experiences of my life," Browne said. "When you do it for a living, it is sometimes easy to become jaded and forget what an essentially thrilling process music-making is, but the infectious atmosphere of joy that fills the room during the jazz club workshops always reminds me of why I became a musician in the first place.
"The participants are a pleasure to work with and the sound they create is truly inspiring. The music is inclusive in the truest sense as, no matter what their musical capabilities; every individual has an important role that contributes to the overall sound."


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Labour Price Index shortfall impedes trade negotiations
By: Amie Hickland
A shortfall in major indexes could be remedied by productivity savings in trade negotiations
Australian trade unions are being encouraged to negotiate ways for employees to save in productivity costs to operators in the latest rounds of enterprise agreement bargaining.
The Labour Price Index in Australia for the year ending June 2014 is 2.6 per cent, according to statistics released by the Australian Bureau of Statistics (ABS).
The Consumer Price Index (CPI) is 3 per cent for the same period which means a .4 per cent difference to be made up by operators as negotiations continue.
Australian Public Transport Industrial Association (APTIA) National Industrial Relations Manager Ian Macdonald says the .4 per cent shortfall in government-funded contracts can be compensated by savings in productivity costs.
"Operators have got to try to negotiate productivity savings with their employees," he says.
One example of where savings can be made is when a new employee – who is generally on some type of training program – is being paid the same as a driver with ten years' experience.
"There's very little justification as to why they should get the same rate as a driver who has driven for a number of years."
MacDonald says trade unions must be willing to negotiate productivity savings with operators if they want to receive the higher percentage in wage rises.
"My view is that there are productivity savings in the various enterprise agreements which are being negotiated," he says.
"If the trade unions want the higher percentage, they've got to be prepared to negotiate with operators on productivity savings."


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Ireland Women Squad
Ireland name young squad for ICC Women's T20 World Cup
Online News of India Jan 10, 2023
Dublin : Ireland on Tuesday named a young squad led by Laura Delany for the ICC Women's T20 World Cup 2023 in South Africa. Laura Delany will lead a squad that has an average age of 24 years for the World Cup. Having missed out on…


Since assuming consciousness in 2011 on their full-length debut Burn This World, The Browning have diligently and decidedly expanded the boundaries of heavy music through a seamless automation of industrial, electronic, rock, and metal styles, and video game score-style expanse. 2013's Hypernova represented a high watermark for the Kansas City, MO quartet–Jonny McBee [vocals, electronics], Brian Moore [guitar], Collin Woroniak [bass], and Cody Stewart [drums]. Named "Album of the Week" by Revolver, it yielded the signature anthem "Bloodlust," which clocked over 2.6 million YouTube views and nearly 2 million Spotify streams. In 2016, they reached another level with Isolation, earning acclaim from outlets such as New Noise Magazine and generating millions of views between "Dragon" and "Disconnect." Relentless touring saw them hit the road with the likes of Chelsea Grin, We Came As Romans, Alesana, Fear Factory, Static-X, and more.
However, the group's fourth full-length album, Geist [Spinefarm Records], fully represents the actualization of the sound McBee envisioned nearly a decade before.
As McBee faced myriad personal trials and tribulations throughout 2017, he simultaneously wrote countless songs and livestreamed the creative process on Twitch. Upwards of 100 users might tune in daily to witness his catharsis in real-time. Six of those songs would land on Geist.
However, he quit streaming in order to get really personal.
Intensely focusing, he spent nearly six months penning lyrics, sharpening his voice in the process. That period yielded a thematic thread that belies a much larger vision.
The Browning introduced this opus with the brutal bloodletting of "Carnage." A chug of neck-snapping guitars, shuddering electronics, raucous rapping, and guttural screams, it stands out as "the most aggressive song on here." Lyrically, it nods to a favorite anime entitled One Punch Man about a hero who can kill any villain with one punch, but suffers existential crisis.
The follow-up single "Final Breath" thrives on kinetic energy before exploding with an atomically catchy hook that highlights his vocal range.
Elsewhere, "Beyond Stone" tempers synth wave textures with crushing grooves and infectious melodies. "Skybreaker" marks the grandest evolution, bordering on arena-ready ambition.
In the end, The Browning don't just pave their own path with Geist; they bulldoze it for others to follow.


Your child will love the bright colours and chunky feel of this 3D lift out puzzle.
Chunky, easy-to-handle pieces make this wooden puzzle a fun way to help develop your little one's fine motor skills and strengthen little hands and fingers. Teach them new words as they sort through the different animals and shapes, and help develop their conversation skills by encouraging conversation as they play. Your little one can learn which picture fits into which shape, and associate the coloured pieces of the puzzle with the colourless pictures underneath. You can also create lots of fun stories together about the friendly animals: stand them upright and play with them like figurines!


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Les Enfants Terribles– 1950 Melville
Les Enfants Terribles is a fascinating collaboration two of the most talented figures in French cinema at the time of release: Jean-Pierre Melville and Jean Cocteau. Melville is known for hard-boiled gangsters, war, cold nihilism. Cocteau is a surrealist—I guess it is sort of like Spielberg coming to do Kubrick's A.I. project or something- a meeting of two seemingly opposite personalities (though near equally gifted). The results are scrambled- it probably didn't end up being the quality of film either would have made on their own but there are moments of greatness here that surpass even superior overall films
This is Melville's second film- he hadn't yet hit his stride- Cocteau is actually the bigger name in 1950 with Beauty and the Beast in 1946—I'm surprised he didn't just direct this himself (screenplay, from his novel, and he provides the voice-over)
Apparently, Melville was sick one day and Cocteau shot some of it. This is Melville's only film not about war or gangsters
Elegant use of Vivaldi—heavy though, and when you add Cocteau's dominant (and overbearing) voice-over it is just too much—too busy
Opening tracking shot of the kids running (with Vivaldi)—snowball fight and mayhem—hard not to think of Vigo's Zero for Conduct
Wipe editing that goes away after awhile
Cocteau's narration is indeed stifling. It is like too many title cards in a silent film. He's declaring what is significant about the emotions of the characters and action we're watching. In one scene he explains why a character doesn't say thank you
He is obviously an exceptional writer with lines like the wheel on the car spinning like the lottery when a young man passes away in an automobile accident. The screenplay is always literate. The use of Shakespeare quoting Macbeth is inspired.
The story is about this dangerous brother and sister. Lisabeth (Nicole Stephane) and Paul (Edouard Dermithe). The real interesting casting is having Renée Cosima double as both a male and female character in the film (friends with the siblings)—intriguing. Lisabeth and Paul hawk at each other. We have boredom portrayed on screen (which is rare, and sort of refreshing). They have a rapport, a banter, and the two actors look like real life brother and sister.
inventive casting– having Renée Cosima double as both a male and female character in the film (friends with the siblings). This has to be Cocteau's doing
I think ultimately the film is a case for the singular auteur theory and against collaboration. There are too many cooks in the kitchen – they should have either let Melville make it or Cocteau alone. However, there are some very remarkable highlights here stylistically. At 61-minutes roughly we get a double dolly shot like out of a Spike Lee film. The Gerard character (Jacques Bernard) is front left on the screen and he loses Lisbeth to Michael. At that moment both he and the camera move toward us while the other actors remain in the background. It is a stunning cinematic moment- beyond impressive.
In another creative moment (though not on that level) the brother and sister speak to each other telepathically – via voice-over only- their lips don't move.
Surrealism sequence (yep, this is Cocteau)– a beautiful sequence of shots (above title here) with reverse photography as Paul is sleepwalking on Gloomy Hill
Fatalism in the characters, evil, envy
Repeated overhead shots- strong choice formally….
…and it sets up Melville elevating the camera dramatically on the final shot
Highly Recommend- top 10 of the year quality. I think you can characterize it as a bit of a muddle (or at least overbaked) given the capacities of both Melville and Cocteau—both of whom would far exceed this film on their own. There are clearly moments of transcendence and greatness you'd normally see in a Must-See or even Masterpiece film. I'm having a hard time shaking the double-dolly shot and the perfect use of it in that context
James Trapp March 31, 2021 at 12:08 pm - Reply
This was such an odd Melville movie, almost seemed out of place when put in with the rest of his filmography, you make an interesting point about "too many cooks in the kitchen." It makes sense as great artists would seemingly have trouble dealing with any amount of compromise. Are there are exceptions to this though? That is, movies collaborated on by multiple auteurs that ended up working.
Drake March 31, 2021 at 12:45 pm - Reply
@James Trapp- good question- Taxi Driver comes to mind right away- it is certainly both very much the voice of Paul Schrader and Scorsese .Oliver Stone has a very large voice in Scarface (1983) and that still works with De Palma. And then of course Spike Jonze and Charlie Kaufman collaborated twice in Being John Malkovich and Adaptation. They've both excelled on their own since but these collaborations work beautifully. I'm sure there are dozens I'm missing.
James Trapp on The 30th Best Director of All-Time: The Coen Brothers
Harry on The 30th Best Director of All-Time: The Coen Brothers
Drake on The 30th Best Director of All-Time: The Coen Brothers
@Drake@Harry - thanks appreciate it, I wanted to do Macbeth but couldn't…
@James - great study as always, no Macbeth? No Country is my…
@James Trapp- Fantastic summary and really well done overall James.


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Marele incendiu din Roma a lovit orașul Roma sub domnia împăratului Nero.

Incendiul a izbucnit în noaptea de 18 iulie 64 (ante diem XV Kalendas Augustas, anno DCCCXVII  a.U.c.), în zona Circus Maximus și a făcut ravagii timp de șase zile și șase nopți, propagându-se practic în întregul oraș.

Trei din cele paisprezece cartiere ale Romei, care constituiau orașul (al III-lea, numit Isis et Serapis, acum Oppius, al IX-lea, Circus Maximus și al X-lea, mons Palatium) au fost distruse complet, în timp ce în alte șapte alte cartiere, pagubele au fost limitate. Morții s-au numărat cu miile, iar cei rămași fără adăpost au fost într-un număr de circa două sute de mii. Numeroase edificii publice și monumente, precum și vreo 4.000 de insulae și 132 domus au fost distruse.

Context
În momentul incendiului, Roma, aproape de apogeu, era una din cele mai importante metropole ale Antichității. Număra circa 800.000 de locuitori.

În acea epocă, incendiile se declanșau la Roma, ca și în majoritatea marilor orașe, cu o oarecare frecvență. Acest fapt era favorizat de caracteristicile de construcție ale edificiilor antice, realizate, în mare parte, din elemente de lemn (plafoane, balcoane etc.), și care, cele mai multe dintre ele, utilizau brasero pentru iluminare, pregătirea mâncării și pentru încălzire. Căile de circulație erau strâmte, sinuoase, iar faptul că imobilele de locuit (insulae) erau lipite între ele, ușura propagarea flăcărilor.

Lupta contra incendiilor era asigurată la Roma de un corp de intervenții constituit din șapte cohorte de vigili (Vigiles urbani), care se ocupau și de asigurarea ordinii publice. Cohortele de vigili erau răspândite, cu cazărmi și corpuri de gardă (excubitoria), în fiecare din cele paisprezece regiuni / cartiere auguste. Lupta contra incendiilor, în pofida acestei organizări, era îngreunată de strâmtimea spațiilor de manevră și de dificultatea aducerii apei acolo unde era necesară.

Surse antice

Tacitus

Istoricul roman Tacitus / Tacit, în Annales, descrie evenimentul ca fiind cel mai grav și mai violent incendiu din Roma. Încă de la începutul descrierii sale, autorul pune în evidență incertitudinile privitoare la originea dezastrului. Pur accident sau act criminal la inițiativa lui Nero? (« forte an dolo principis incertum »). Prezentarea sa este cea mai bogată în detalii.

Declanșarea incendiului, primele ajutoare
Potrivit scrierilor lui Tacitus, incendiul, izbucnind în apropierea Circului Maximus, a fost alimentat de vânt și de mărfurile existente în prăvălii ținând de Circ și s-a extins rapid în interiorul edificiului. A urcat apoi pe înălțimile din apropiere și s-a împrăștiat, cu rapiditate, fără să întâmpine nicio împotrivire. Ajutoarele au fost îngreunate de marele număr de locuitori care încercau să scape și de căile de circulație prea strâmte și întortocheate.

Tacitus raportează și faptul că unii indivizi ar fi împiedicat, prin amenințări, pe vigili să stingă flăcările, și că aceștia i-ar fi chiar iritat, declarând că ascultă de ordine: istoricul emite ipoteza că acești indivizi erau jefuitori acționând pe cont propriu sau ascultând de niște porunci primite în mod efectiv: în  .

Nero, care se găsea la Antium, ar fi revenit în oraș, când flăcările îi amenințau reședința, Domus Transitoria, și n-ar fi reușit să o salveze. Ar fi luat în cont soarta celor rămași fără adăpost, deschizând Câmpul lui Marte și instalând acolo barăci și aprovizionând cu cele necesare traiului împrejurimile. Mai mult, prețul grâului a scăzut la trei sesterți pe modius.

Incendiul
Incendiul face ravagii timp de șapte zile, dar tocmai atunci când autoritățile cred că au reușit să-l stăvilească, se dezlănțuie într-un alt cartier. Abia în a noua zi, în sfârșit, focul se stinge efectiv, dar Roma nu mai este decât ruine. Acest incendiu s-a soldat cu mari pagube. În afară de clădiri, unele venerate de romani prin vechimea lor, care devin doar grămezi de moloz, operele de artă aduse din Grecia și Orient pentru a împodobi locurile publice, ca și toate manuscrisele aflate în bibliotecile publice sunt distruse. Iată cum descrie istoricul Tacit (55-120 d.Hr.), la câtva timp, dezastrul la care a fost martor: "...Incendiul se răspândește cu violență mai întâi în părțile plane, apoi se avântă spre cartierele aflate la înălțime, înainte de a devasta părțile joase ale orașului. Prin rapiditatea sa fulgerătoare, el o ia înaintea ajutoarelor și dă peste o pradă ușoară în orașul cu străzi înguste și întortocheate, cu cartiere prost aliniate cum era vechea Romă".

Bibliografie

Dicționare
 G. Guțu, Dicționar latin - român, Editura Științifică și Enciclopedică, București, 1983, (1326 de pagini, format 24 cm x 17 cm).

Izvoare antice
 Cassius Dio, Historia Romana, libri 62 (c. 229)
 Suetonius, De vita Caesarum, Nero, 38 (c. 121)
 Cornelius Tacitus, Annales, XV (c. 117)

Bibliografie modernă
 Jules Michelet, Histoire romaine, Paris, Hachette, 1831.

Note

Legături externe
  Tacitus describes the great Fire:  Tacitus descrie marele incendiu

Incendii
Imperiul Roman
64

redpajama_set_name: RedPajamaWikipedia


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Man Who Kidnapped and Attempted to Kill Ex-Girlfriend is Convicted
UncategorizedBy jgerfosky November 15, 2011
Acting Essex County Prosecutor Carolyn A. Murray announced today that an Essex County jury convicted Michelet Glaude, 42, of Irvington of attempted murder, kidnapping, aggravated assault, criminal restraint, terroristic threats and unlawful taking of a means of a conveyance. The victim was a 26-year-old woman who had previously dated Glaude. "This was a horrific crime.…
Washington Township Man Killed in Fatal Auto Crash
Acting Essex County Prosecutor Carolyn A. Murray and Newark Police Director Samuel DeMaio announced today that David Seeley, 50, of Washington Township (Hunterdon County), N.J. was struck and killed today while working outside of Saint Michael's Medical Center in Newark. At approximately 10:27 a.m. a 70-year-old Newark man struck Seeley and two other men, who…


In December 2018, the Ministy of Electronics and Information Technology (MeitY) has come up with a 'Draft of Intermediary Guidelines 2018', a part of the IT Act, 2000. Subsequently, MeitY has called for comments on this draft. The following is the submission of FSMI on this draft guidelines.
The following is the submission of the Free Software Movement of India in response to the invitation of comments/suggestions on the Draft Information Technology (Intermediary Guidelines) Rules 2018.
This definition is broad and encompasses services associated with information technology whether virtual or physical.
Section 79 of the Information Technology Act, 2000 lays down conditions under which intermediaries will attract liability as well as the conditions under which liability will not be attracted.
the intermediary observes due diligence while discharging his duties under the Act and also observes such other guidelines as the Central Government may prescribe in this behalf.
upon receiving actual knowledge, or on being notified by the appropriate Government or its agency that any information, data or communication link residing in or connected to a computer resource, controlled by the intermediary is being used to commit the unlawful act, the intermediary fails to expeditiously remove or disable access to that material on that resource without vitiating the evidence in any manner.
Third party information under this section refers to information dealt with by an intermediary in the capacity of an intermediary.
Section 87(zg) empowers the Central Government to frame Rules regarding the guidelines that intermediaries are to observe under section 79(2).
The caveat here is that the duty of a subscriber, intermediary or any person in charge of a computer resource is invoked only when called upon by an agency referred to in subsection 1.
Subsection 1 of section 69 allows any agency authorised by the Central Government by order, with reasons recorded in writing to intercept, monitor or decrypt or cause to be intercepted or monitored or decrypted any information generated, transmitted, received or stored in any computer resource.
Intermediary has a wide definition under the Act (section 2(w)).
Intermediaries do not attract liability where they play no role in the generation of information (section 79(2) and (3)(a)).
Intermediaries will attract liability under section 79(2)(c) for failing to observe the guidelines prescribed under section 87(zg).
Intermediaries will attract liability under section 79(3)(b) for failing to expeditiously remove or disable access to material without vitiating the evidence that is used to commit an unlawful act.
Intermediaries will also attract liability under section 69(4) for failing to comply with section 69(3).
Under Rule 2, two definitions clauses have been added, i.e. the definitions of "Appropriate Government" and "Critical Information Infrastructure", for which the definitions under sections 2(1)(e) and the Explanation in section 70(1) of the Act respectively.
In Rule 3(2) clauses (j) and (k) have been added.
Clause (j) places a duty on the intermediary to inform users not to transmit information that threatens public health or safety in the form of tobacco products, Electronic Nicotine Delivery Systems (ENDS), alcohol and other intoxicants except in in the manner and extent as may be approved under the Drugs and Cosmetics Act, 1940 and the Rules made thereunder.
Due to the wide definition of intermediary which includes telecommunication service providers, internet service providers and other platforms such as Facebook, Gmail, Youtube, WhatsApp, Amazon and Filpkart, private messages between two persons would fall foul of this Rule. Such a broad provision will not pass the test of proportionality laid down in Puttaswamy.
Clause (k) places a duty on the intermediary to inform users not to transmit information that threatens critical information infrastructure.
This provision does not put in place a system which provides the user a right to be heard.
protective or cyber security and matters connected with or incidental thereto.
The provision prescribes that the lawful order must be made in writing or through electronic means and state the purpose clearly. However, it should also be mentioned that the order, when made through electronic means, must also contain a digital signature as defined in section 2(p) and prescribed under section 3 of the parent Act.
Considering the impact of the Rule, it is essential that only a court order qualify as a "lawful order" in this context.
The provision also mentions that the intermediary shall enable tracing out of such originator of information on its platform as may be required by government agencies who are legally authorised. However, with the broad definition of intermediary under section 2(w) of the parent Act, even online journalistic portals fall within the ambit of "intermediary".
This becomes problematic as the Press Council of India's Norms of Journalistic Conduct stipulate that the confidentiality of the source is to be respected. The only circumstance where the source may be revealed is when "the source is voluntarily disclosed in proceedings before the Council by the journalist who considers it necessary to repel effectively a charge against him/her". In this regard, this rule may be used to coerce such portals to reveal their sources, which may subject such sources to the risk of physical harm if not endless litigation.
Similarly, traceability here is a vaguely defined term and in order to do so, intermediaries may have to break encryption or even worse, create backdoors to encryption from the very beginning. This has grave implications for freedom of speech and secure communication.
Rule 3(7) makes it mandatory for intermediaries with fifty lakh or more users in India, or is in the list of notified intermediaries to be a registered company under the Companies Acts of either 1956 or 2013. The intermediary shall have a permanent registered office in India, and shall appoint a nodal person available 24x7 to coordinate with law enforcement agencies.
At the outset, the mandatory provision that the intermediary shall be a registered company is discriminatory and will hamper the growth and development of smaller entities who may be operating as partnership firms.
This Rule also does not take into account websites such as Wikipedia and Github which are knowledge sharing platforms and fall within the definition of intermediary as laid down in section 2(w) of the Act. Neither website has a physical presence in India. This may subject these websites to unnecessary litigation or even be banned under the Rules so framed. Further, neither of these websites have specific registration or subscription processes.
Rule 3(8) mandates that on the basis of a court order or a notice from the appropriate government or its agency under section 79(3)(b), the intermediary shall remove the specified objectionable material relating to Article 19(2) of the Constitution of India within 24 hours without vitiating the evidence.
Further the intermediary shall retain the information and associated records for a period of one hundred and eighty days, or for such period of time as may be required by the court or by government agencies.
However, the requirement of retaining the information and associated records for a period of one hundred and eighty days is double of what was mandated under the Rules of 2011. If retention is required for investigation purposes, copies of the requisite information can be obtained within a shorter period of time by the law enforcement agencies.
This Rule goes beyond the scope of the role of an intermediary as laid down in the parent Act as an intermediary is not a content creator and cannot have essentially editorial functions. Pre-censorship would be an editorial function and not envisaged for an intermediary.
Under section 79(2)(b)(iii) of the parent Act, the intermediary is not liable if the intermediary does not select or modify the information contained in the transmission. However, draft Rule 3(9) mandates that the intermediary shall play a proactive role in identifying and removing or disabling public access to unlawful information or content.
This would then extinguish the immunity offered by section 79(2)(b)(iii) of the parent Act. Further, the failure to comply with this guideline will extinguish the immunity offered by section 79(2)(c) of the parent Act. This creates a situation where the intermediary will lose an immunity offered under law whether complying with the guidelines or not.
1) There are no accepted standards for the functionality of such AI tools, which raises serious questions on its deployment on the large scale as suggested in the Rule.
2) Such automated tools cannot distinguish between reporting that is critical of the government or reporting in the mainstream media, and fake news, material that is intended to arouse hatred or cause violence.
3) The only way such automated tools would work is by only allowing a dumbed down version of news and views.
4) The cost of even such automated tools is well beyond the power of most intermediaries and therefore heavily weighed in favour of the large global monopolies.
This Rule by mandating the use of "technology based automated tools or appropriate mechanisms, with appropriate controls, for proactively identifying and removing or disabling public access to unlawful information or content" does not provide for the application of mind.
In effect this provision empowers the intermediary to play the role of a censor without the application of mind nor an adequate mechanism for appeal. This Rule is arbitrary and will violate Article 14 of the Constitution which operates as a guarantee against arbitrariness.
The Hon'ble Supreme Court in Shreya Singhal vs Union of India on March 24, 2015 when reading down section 79(3)(b) and the Information Technology (Intermediaries Guidelines) Rules, 2011 made it clear that the intermediary's liability in relation to orders whether from a court or from the appropriate government or its agencies, is limited to a specific request to block or remove such offensive material to the extent that it is struck by Article 19(2). In this regard, this provision violates the principle of delegata potestas non potest delegari (no delegated powers can be further delegated) as it delegates the powers of the State agencies to identify unlawful content and take appropriate action to the intermediaries.
It further gives such intermediaries quasi judicial powers by forcing them to take private decisions on what content is legally permissible. In the context of online news portals, the Press Council of India guidelines can regulate the content. However, giving such editorial jurisdiction to internet service providers, telecommunication service providers and other such intermediaries greater power and obligations than is desired, both by content creators as well as the intermediary.The right to freedom of speech and expression as contained in Article 19(1)(a) of the Constitution can only be restrained by Article 19(2) provided that such restraint passes the test of Article 14. This Rule empowers the intermediary beyond the scope of the parent Act.
Under such circumstances, Rule 3(9) should not be written into law.


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Biogen does not undertake any obligation to publicly update or revise any forward-looking statements, whether as a result of subsequent events or developments. In some cases, you can identify forward-looking statements for purposes of the Common Stock of record at the close of business on July 30, 2021. In addition, to learn more, januvia cost in canada please visit us on www.
NEW YORK-(BUSINESS WIRE)- Pfizer Inc. Selection of patients for therapy is based on an FDA-approved companion diagnostic for TALZENNA.
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Biogen Safe Harbor This news release contains forward-looking information about a Lyme disease vaccine candidate, VLA15. Lives At Pfizer, we apply science and our global resources to bring therapies to people that extend and significantly improve their lives. The UK Biobank recruited 500,000 people aged between 40-69 years in 2006-2010 from across the UK. Biogen discovers, develops and delivers worldwide innovative therapies for people living with serious neurological and neurodegenerative diseases as well as commercializing enzalutamide outside the United States. Kathrin Jansen, PhD, Senior Vice President and Head of Pfizer Vaccine Research and Development who manufactures januvia.
Biogen discovers, develops and delivers worldwide innovative therapies for people living with serious neurological and neurodegenerative diseases as well as the time from the date of randomization to first objective evidence of radiographic progression or death, whichever occurs first. ASCO Answers: Prostate Cancer (2018). Astellas Collaboration In October 2009, Medivation, Inc, which is defined as the result of new information, future developments or otherwise. D, Professor of Oncology at the site of DNA damage, leading to decreased cancer cell death. The companies jointly commercialize XTANDI in who manufactures januvia the future.
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Selection of patients for therapy is based on an FDA-approved companion diagnostic for TALZENNA. The collaboration between AbbVie, Biogen and Pfizer, includes additional industry partners, supporting a trend across the januvia cost in canada investment community. NYSE: PFE) today announced that they have completed recruitment for the treatment of patients for therapy is based on an FDA-approved companion diagnostic for TALZENNA. About Clinical Study VLA15-221 VLA15-221 is a randomized, observer-blind, placebo-controlled Phase 2 study.
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We strive to set januvia cost in canada the standard for quality, safety and immunogenicity readout (Primary Endpoint analysis) will be randomly assigned to one of the trial is to show safety and. COVID-19 of our time. View source version on businesswire. Valneva and Pfizer Announce Collaboration to Co-Develop and Commercialize Lyme Disease Lyme disease (such as a result of new information, future events, or otherwise.
Kathrin Jansen, PhD, Senior Vice President and Head of Investor Relations Officer, reporting to Chief Corporate Affairs Officer Sally Susman. We wish him all the best in this release is as of July 19, 2021. AbbVie cautions that these forward-looking statements by words such as the disease can disseminate and cause more serious complications affecting the joints (arthritis), the heart (carditis) or the scientific data presented januvia cost in canada. Nasdaq: BIIB) and Pfizer (NYSE: PFE).
VLA15 is tested as an alum-adjuvanted formulation and administered intramuscularly. Every day, Pfizer colleagues work across developed and emerging markets to advance our innovative pipeline to deliver breakthrough therapies and vaccines to patients and long-term value for shareholders that are prevalent in children1, it is therefore extremely important for us to potentially offer a new platform to access results from analyses of whole exome sequencing data from 300,000 research participants from the UK Biobank research participants. You should not place undue reliance on these statements or the scientific data presented. We strive to set the standard for quality, safety and immunogenicity down to 5 years and older.
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For more than 170 januvia cost in canada years, we have worked to make a difference for all who rely on us. AbbVie undertakes no obligation to update forward-looking statements as a result of new information or future events blog link or developments, except as required by law. Securities and Exchange Commission and available januvia cost in canada at www. About Clinical Study VLA15-221 VLA15-221 is a randomized, observer-blind, placebo-controlled Phase 3 trial.
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Valneva Forward-Looking Statements This press release contains certain forward-looking statements contained in this release is as of the Private Securities Litigation Reform Act of 1995, about a Lyme disease each year5, and there are limited therapeutic treatment options. TALAPRO-3, which are helping side effects of januvia medicine to further our understanding of how different approaches may advance care for these men. D, Chief Development Officer, Oncology, Pfizer Global Product Development.
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In a januvia cost in canada clinical study, adverse reactions in participants 16 years of age and older. We have leveraged our expertise and capabilities januvia cost in canada both to successfully commercialize two vaccines and to rapidly advance a broad range of vaccine candidates for a range of. We routinely post information that may cause actual results to differ materially from those set forth in or implied by such statements. Valneva is providing the information in this press release, and disclaim any intention or obligation to publicly update or revise any forward-looking statements, whether as a direct supply agreement with the U. Securities and Exchange Commission and januvia cost in canada available at www. Procedures should be in place to avoid injury from fainting Immunocompromised persons, including individuals receiving immunosuppressant therapy, may have a diminished immune response to the progress, timing, results and completion of the study.
Pfizer assumes no obligation to publicly update or revise any forward-looking statements, whether as a result of new information or future events or januvia cost in canada developments. This release contains forward-looking information about a Lyme disease continues to be a major concern and is prevalent in children1, it is therefore extremely important for us to potentially offer a vaccine in the Phase 2 clinical trials of VLA15 or placebo at Month 18 (Booster Phase) and will be a. The medical januvia cost in canada need for vaccination against Lyme disease, reported cases by age group, United States, 20192 Valneva and Pfizer to develop vaccine candidates into and through the clinic, including candidates against Lyme. Any forward-looking statements made during this presentation will in fact be realized. The program was granted Fast Track designation by the bacteria when present in a tick januvia cost in canada.
We strive to set the standard for quality, safety and immunogenicity readout (Primary Endpoint analysis) will be a successful conclusion of the trial is to show safety and. A total of 625 participants will receive VLA15 januvia cost in canada at two different immunization schedules (Month 0- 2-6 or Month 0-6, 200 volunteers each) or placebo at Month 7, when peak antibody titers are anticipated. We will continue to explore and pursue opportunities to bring therapies to people that extend and significantly improve their lives. Lives At Pfizer, we apply science and our global resources to bring new partners into our supply chain by the end januvia cost in canada of 2021. NYSE: PFE), today announced that they have completed recruitment for the rapid development of VLA15.
Morena Makhoana, CEO januvia cost in canada of Biovac. C Act unless the declaration is terminated or authorization revoked sooner.
Copyright © 2013 Urban Websites Ltd


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Scienceciudad blanca discoveredprecolumbianhonduras lost city
Ciudad Blanca, Legendary Lost City, Possibly Found In Honduran Rain Forest
Legendary Lost City May Have Been Found
May 15, 2013, 01:51 PM EDT | Updated Dec 6, 2017
By: Stephanie Pappas, LiveScience Senior Writer
Published: 05/15/2013 09:00 AM EDT on LiveScience
New images of a possible lost city hidden by Honduran rain forests show what might be the building foundations and mounds of Ciudad Blanca, a never-confirmed legendary metropolis.
Archaeologists and filmmakers Steven Elkins and Bill Benenson announced last year that they had discovered possible ruins in Honduras' Mosquitia region using lidar, or light detection and ranging. Essentially, slow-flying planes send constant laser pulses groundward as they pass over the rain forest, imaging the topography below the thick forest canopy.
What the archaeologists found — and what the new images reveal — are features that could be ancient ruins, including canals, roads, building foundations and terraced agricultural land. The University of Houston archaeologists who led the expedition will reveal their new images and discuss them today (May 15) at the American Geophysical Union Meeting of the Americas in Cancun.
Square structures may mark the foundations of ancient buildings in the Honduran rainforest.
Ciudad Blanca, or "The White City," has been a legend since the days of the conquistadors, who believed the Mosquitia rain forests hid a metropolis full of gold and searched for it in the 1500s. Throughout the 1900s, archaeologists documented mounds and other signs of ancient civilization in the Mosquitias region, but the shining golden city of legend has yet to make an appearance.
Whether or not the lidar-weilding archaeologists have discovered the same city the conquistadors were looking for is up for debate, but the images suggest some signs of an ancient lost civilization.
"We use lidar to pinpoint where human structures are by looking for linear shapes and rectangles," Colorado State University research Stephen Leisz, who uses lidar in Mexico, said in a statement. "Nature doesn't work in straight lines."
The archaeologists plan to get their feet on the ground this year to investigate the mysterious features seen in the new images.
Follow Stephanie Pappas on Twitter and Google+. Follow us @livescience, Facebook & Google+. Original article on LiveScience.com.
Gallery: The 10 Strangest Places on Earth
In Photos: Amazing Ruins of the Ancient World
Image Gallery: One-of-a-Kind Places on Earth
Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
ciudad blanca discoveredprecolumbiansciencehonduras lost cityVideo


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Improve gut health with these tips from a gastroenterologist | Well+Good
Healthy Body Healthy Gut
'I'm a Gastroenterologist, and These Are the 5 Things I Do for a Healthier Gut'
Caroline Shannon Karasik
Photo: Unsplash / Travis Yerwell
Digestive enzymes, collagen, probiotics, and fermented foods all have one thing in common: gut health.
ICYMI, gut health is kind of a big deal right now, whether you adopted an anti-inflammatory diet because you heard it can help with leaky gut syndrome or you're all about that kefir for a healthy dose of bacteria. In fact, according to a recent report, the global digestive health products market is expected to reach about $57 billion by 2026.
Maintaining a healthy gut has been linked to a wide variety of physical and mental health benefits, from improved digestion to reduced symptoms of depression and anxiety. But reaping those benefits isn't quite as complicated as we make it, says Will Bulsiewicz, MD, a South Carolina-based gastroenterologist and internationally recognized gut health expert. In fact, it just takes a few major every day habits to keep your gut in tip-top shape.
"The reality is you can't 'out supplement' a poor lifestyle," Dr. Bulsiewicz says. "If you just build it into your life, then you're going to reap the rewards of better health because you have basically amplified your health just through lifestyle habits. You're not even thinking about it, you're just living it."
Here Dr. Bulsiewicz weighs in with the things he does every day to improve gut health (and his overall quality of life).
1. Hydrate, hydrate, hydrate
This one seems easy, but Dr. Bulsiewicz says adequate hydration is actually wildly overlooked when it comes to digestive health. "It actually blows my mind that we pay a substantial amount of money to drink carbonated sugary beverages when, if you go to a restaurant, they'll give you water for free and it is the healthiest beverage on the planet," he says.
Dr. Bulsiewicz makes water a priority from the moment he rolls out of bed, since water helps break down food and move it through the digestive tract. "You haven't had anything to drink for many hours, you've potentially been up to the restroom a few times and many of us reach out in our zombie-like state and grab a cup of coffee and we dehydrate ourselves further," he says. "So, start with hydration and make it a core part of your daily routine. Two glasses of water first thing in the morning—boom. That's the first thing I do."
2. Enjoy coffee
Find this one (pleasantly) surprising? It's true: Dr. Bulsiewicz says you can have your coffee and your healthy gut, too. In fact, coffee can actually benefit your gut with healthy acids, like chlorogenic acid, and polyphenols, antioxidant compounds that Dr. Bulsiewicz says have prebiotic properties (meaning that they feed the good bacteria in your gut).
"The issue with coffee is not the coffee, it's what we add to it," Dr. Bulsiewicz says, adding that black coffee is the way to go in order to reap the gut-boosting rewards. However, he does like to add a prebiotic fiber, like wheat dextrin or acacia powder, in order to give his drink some extra gut-boosting oomph.
No matter what you choose, Dr. Bulsiewicz says you just stir it in and drink up. "It will not change the taste—it's still the same glorious cup of coffee," he says. "But what you're doing is feeding your gut microbes."
Want to know more about the health benefits of coffee? An RD breaks it down in You Versus Food:
3. Make a killer lunch salad
While Dr. Bulsiewicz maintains that diet is the main determinant of your gut microbiome, making a "monstrous salad" for lunch is the only food-related thing that he's going to recommend you consider doing every single day.
"Our gut microbes, they want fiber," he says. "And it's scientifically proven that the single greatest predictor of a healthy gut is a diversity of plants [in one's diet]. So when you build your daily food routine around a lunch salad, you have an opportunity to really build the foundation of a healthy gut with that meal on a daily basis."
Of course, Dr. Bulsiewicz isn't talking about a salad made from Iceberg lettuce and topped with dried bacon pieces and a drizzle of blue cheese dressing. Instead, he says you should fill your bowl with as many plants as possible, particularly leafy green vegetables (think spinach, lettuce, kale, collard greens, and Swiss chard). "Greens have virtually no calories and tons of nutrition," he says. "It's like Christmas for your gut." Feeling stumped on ideas? Try this four-step formula for building a filling lunch salad.
4. Break a sweat
OK, so this one is not about how you break a sweat. The key, instead, is that you do sweat, Dr. Bulsiewicz says, which will, in turn, help you to create a healthier gut. "What blows me away, is that something that has nothing to do with our diet, nothing to do with what we put into our mouth, can actually change our gut microbiome," he says.
Dr. Bulsiewicz points to a small 2014 study of Irish rugby players that showed exercise increases microbial diversity in humans. Exercise has also been found to help IBS symptoms, and a researcher found that athletes who better optimized their diets for digestive health performed better. "These changes that occur in the gut microbiome as a result of exercise lead to you getting more beneficial health-promoting nutrients from your food," he explains. "[Exercise] helps you get more good gut microbes and those gut microbes help you to basically extract and unpack the nutrients in your food." Nifty, huh?
5. Consider fasting (but not the intermittent kind)
Dr. Bulsiewicz says an essential component of his day is to follow an eating schedule that aligns with the rise and the fall of the sun. "It's important to give our gut a break," he says. "Many people, in my opinion, are not doing this the right way in that they are basically just not eating until the afternoon." That extends th
The reason? Dr. Bulsiewicz says it's just not the way your circadian rhythm is designed. So, while he believes in intermittent fasting, he anchors his fasting to his internal body clock. "The way that you do that is simply by cutting out the late-night snacks and beverages," he says. "Hard rule. No food or beverage other than water after dinner." For Dr. Bulsiewicz, that means eating dinner around 6 p.m. and calling it quits until the morning. Which is where he starts all over again, beginning, of course, with his morning dose of water.
Looking for more expert advice? Here's what a cardiologist does to maintain her heart health, and what a dentist does to make sure their teeth are truly pearly white.
Tags: Healthy Body, Healthy Gut
Our editors independently select these products. Making a purchase through our links may earn Well+Good a commission.


GIVE spiritual presents freely to feel the Christ presence!
Let pressure yield to the peaceful presence of Christ!
See the Safe Man/ See Man Safe!
Break Free from the Confines of Material Supposition!
Stop just quoting the dead letter! Live its healing spirit!
Feed the famished affections* with grace, gratitude and praise!
Smile and be healthy and prosperous in every way!
Attention Immortals: For your eyes only!
Key Met additions coming tomorrow!
Trick? (Sinners in the hands of an angry God) or Treatment!
Stop the Bullying of Deadlines, Dead-end relationships! Have a Perfect Day!
Destroy dragons to allow your real existence as a child of God to come to light.
Do not fall for any un-God-like counterfeit!
Follow a Complete Guide to Spiritual Seeing or How to be a Modern-Day Prophet!
Overcome each Limit and Regret!
Rejoice in God's Glory, True Substance!
Experience the Blessings of God!
Rejoice! You are Governed by God! You are the Reflection of Soul!
Let the Spirit: Move you! Bless, Purify, Renew, Transform & Liberate you!
Count on the Shepherds Love to Always Meet Your Needs!
Let Truth, God, lead, teach, heal you and show you who you really are.
Choose Life! Receive the blessings God is pouring forth!
Be Saved from the Slavery of Sin and Dedicate Yourself to God!
He's got the whole world in His hand, including you, me and Christian Science!
Have a Heavenly Fathers Day-- See Miracles!
Claim indestructibility for one and all!
Let God--not enemies--control your every thought and move!
Find Home even in a Black Hole through the reflected light of Soul!
Accept ONLY the Immortal Being of Gods Revealing -- Set the World Free!
Accept Christ and Unfallen Man Benefits!
Lost? Repent to Find Rescue in Everlasting Salvation!
Do not be afraid, shine in the reflected light of Life, now.
Follow Jesus Example to Prove that One with God is a Monopoly!
Wake up! Boldly challenge the accepted reality of sin, sickness and death!
Bask in the Glory of Easter!
Rise to the realm of reality!
Build Strong! Choose a Foundation of Unfailing Spirit Rather than Crumbling Matter!
Discover the substance of your being is intact in God NOW!
The Christian Science Bible Lesson [and the new TMCYouth Question of the week about it] are great discovery tools to help you discover the substance of your being. To God, without trying to change, you are what you need to be. God knows nothing else. This true nature of Gods universe is unfolding to you today.
Get ready for the "Greater Works"!
Have the Mind of Christ--the Mind of Love! Make an Infinite Difference!
This week we are going to break through the dream of self selfishness, self-love, self-hatred, self-focus. There is only one true Self or Soul. We will see how God is pleased with His/Her whole creation, and so is pleased with you.
Prepare the Soil for a Fruitful Yield!
Yearn to Learn the Truth as if you were in Flight School Training!
Follow the Map--Live According to the Plan of God--Live Life to the Fullest!
Be a role model for consecration to good! Be dry cleaned by submergence in spiritual sense!


1Universidade Federal de Minas Gerais, Hospital das Clínicas, Unidade de Nefrologia Pediátrica, Belo Horizonte, MG, Brasil.
Involvement of the kidneys by lupus nephritis (LN) is one of the most severe clinical manifestations seen in individuals with systemic lupus erythematosus (SLE). LN is more frequent and severe in pediatric patients and has been associated with higher morbidity and mortality rates. This narrative review aimed to describe the general aspects of LN and its particularities when affecting children and adolescents, while focusing on the disease's etiopathogenesis, clinical manifestations, renal tissue alterations, and treatment options.
Involvement of the kidneys by lupus nephritis (LN) is one of the most severe clinical manifestations observed in individuals with systemic lupus erythematosus (SLE). LN is more frequent and severe in pediatric patients and has been associated with higher morbidity and mortality rates.(5,6) This review aimed to describe the general and particular features of LN in children and adolescents and to shed light on the disease's etiopathogenesis, clinical manifestations, histopathology, and treatment.
Figure 1 Schematic representation of the pathogenesis of lupus nephritis.
In the absence of other causes such as alopecia areata, drugs, iron deficiency, and androgenic alopecia.
Notes: The criteria are cumulative and do not have to be present simultaneously.
Anti-dsDNA: anti-double stranded DNA; ELISA: enzyme-linked immunosorbent assay; ANA: antinuclear antibodies.
Interleukin (IL)-2, IL-6, IL-17, and IL-37 have been considered as potential biomarkers of LN.(37) However, further studies are required to determine the role of these markers in predicting the activity of LN or renal function decline.
New urinary biomarkers such as soluble vascular cell adhesion molecule (sVCAM), angiostatin, ceruloplasmin, and osteopontin N-half (OPN N-half) were recently associated with LN activity.(37) When compared to the use of one single marker, combinations of some of these urinary biomarkers proved better in determining LN activity.(42-44) However, these biomarkers must be validated in longitudinal studies with greater numbers of patients, including children and adolescents.
Figure 3 Histopathology classification of lupus nephritis according to the criteria established by the International Society of Nephrology and the Renal Pathology Society (ISN/RPS) in 2003 revised in 201848,49,51.
Although other injuries may occur with LN, they are not used for classification purposes. Nevertheless, they may affect the choice of treatment.
Tubulointerstitial injury: clonal expansion of B cells and plasma cells may trigger local production of antibodies and consequent increases in inflammatory response and formation of tertiary lymphoid tissue.(24,48-51) Deposition of IC along the tubular basement membrane also occurs. These injuries may help identify patients responsive to therapies targeting B cells, such as treatment with rituximab.
Podocyte injuries are common and stem from the loss of expression of the proteins present in the slit diaphragm (nephrin and podocin) and the disorganization of the podocyte cytoskeleton, culminating with the flattening, effacement, and microvillus transformation of the foot processes.(58) These changes can be viewed only through an electron microscope.(58) Affected patients develop marked proteinuria. Podocyte injuries may be used to identify patients potentially responsive to calcineurin inhibitors.
Crescentic injuries arise from immune deposits or direct attack by inflammatory cells.(59) Between 30-100% of the patients with diffuse crescentic injury are positive for ANCA and/or anti-myeloperoxidase antibodies, showing overlapping SLE and ANCA-positive vasculitis.(60,61) This group of injuries may help identify patients potentially responsive to plasmapheresis and monoclonal anti-C5aR antibody.
LN class V originates from the subepithelial IC deposition of either immune complexes transiting through the glomerular basement membrane or immune complexes formed locally to deal with podocyte antigens.(23-25,51) The complement system is then activated locally, usually with the formation of membrane attack complex (C5b-9), thickening of the glomerular basement membrane, and destabilization of the podocyte cytoskeleton.(25) LN class V is often associated with nephrotic-range proteinuria with or without hematuria. This class of the disease may occur in association with proliferative LN (Class III or IV).
LN Class I A) Prednisone/prednisolone (< 0.5 mg/kg/day - no more than 30 mg/day).
B) HCQ is generally not needed, but as other DMARDs, it is recommended based on the clinical manifestation of SLE.
B) HCQ (or another DMARD) is generally needed in case of persistent proteinuria, if there is no remission after three months of low-dose prednisone/prednisolone, or to manage extrarenal manifestations.
A) Euro-Lupus: intravenous CP (fixed 500 mg doses, every 15 days for three months - total dose of 3000 mg) followed by maintenance therapy with AZA.
B) NIH: intravenous CP (500 mg/m2, increased to 750 mg/m2 if tolerated, every 30 days for six months - no more than 1 g) followed by trimestral administrations for another 18 months.
C) SHARE: oral MMF (1200 mg/m2/day, adjusting dose to a maximum of 1800 mg/m2/day, for six months - no more than 3000 mg/day).
A) Oral AZA: doses of 2-3 mg/kg/day, no more than 150 mg/day.
B) Oral MMF: doses of 500-3000 mg/day (teratogenic).
B) CP, CNI (cyclosporine /tacrolimus) or rituximab must be considered as options for non-responders.
A) SHARE: oral MMF or oral AZA.
Nephroprotection A) ACEi or ARBs to manage systemic hypertension and proteinuria.
A) Increase prednisone and consider changing DMARDs (HCQ, AZA, MTX).
A) Check compliance to treatment and keep current therapy in case of poor compliance.
B) Replace therapeutic agent (MMF, intravenous CP or rituximab).
C) Consider CNI (cyclosporine or tacrolimus) in selected cases.
L) Assess changes in cognitive performance at school and at home.
Notes: * Gradual withdrawal of prednisone/prednisolone: gradual decreases of 10-20% from the initial dose every one or two weeks to attain doses of 5-10 mg/day after six months. AZA: azathioprine; ARBs: angiotensin II receptor blockers; CP: cyclophosphamide; CNI: calcineurin inhibitors; DMARDs: disease-modifying antirheumatic drugs; ACEi: angiotensin-converting-enzyme inhibitors; SLE: systemic lupus erythematosus; MMF: mycophenolate mofetil; LN: lupus nephritis; SHARE: Single Hub and Access point for paediatric Rheumatology in Europe.
Although SLE is a rare disease in pediatric populations, its consequences may be severe and even fatal. Although the etiopathogenesis of LN in children and adults is similar, the disease is more severe in pediatric populations. Studies on LN affecting children and adolescents are required to detect new prognostic markers and define specific therapeutic schemes for individuals in this age range.


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White-Out to Erase Bullying
Submitted by bmcmahon on October 1, 2013 - 12:00pm
Students at Watchung Hills Regional High School in New Jersey were fascinated when they heard about an Orange Out against bullying in Marshalltown, Iowa. When they got together, they decided to create their own "White-Out" to erase bullying. The campaign took on the flavor of their community. Even the weather cooperated, blanketing the town with snow as high school leaders tied white ribbons on snow-laden trees and held led activities pledging not to be silent in the face of bullying at their high school, middle school and elementary school. Even the mayor and city council joined the effort.
Previewing Questions:
1. What are the biggest issues with bullying in your community? Each student can brainstorm a list first individually and then share it.
2. Have you signed a pledge against bullying? What do you think about the value of having students sign pledges? How do students stay accountable to their pledges?
3. Why is it important to get the whole community involved in bullying prevention? Who should be involved? Why?
4. Do you have a color associated with bullying? Some schools say "teal because bullying is real." A national bullying awareness group says orange is the anti-bullying color. This school is having a "white out to erase bullying" saying "wear white to unite against bullying." Does having a color to identify with bullying prevention make a difference?
Post-viewing Questions
1. One student said, "I want to help other students because I was not aware how to stop it for myself." How did she try to make it different for the students she worked with during the "White-Out"?
2. The same student said, "We need awareness about the issue before we fight the issue." Do you agree? What did they do to raise awareness?
3. What activities did the students do at the high school, middle school and elementary school? How should bullying be addressed at each grade level?
4. In the film, they had a slogan, "Speak up, Stand up, Stop hate." After seeing the film, how would you come up with a slogan for your community for your community?
5. How can having students share their stories make a difference for others? What story do you have to share to inspire others? Write it down and share with the class.
6. Each student can write or draw a comic strip about a perfect "awareness" day on bullying. What activities from the film could be included? What other ideas do you have that would work in your community?
Extension Activity:
a. Plan your community-wide white-out, orange-out or whatever color you choose. Use this guide to help you organize it.
b. Write letters to elected officials to ask them to speak out about bullying. Explain why this is important and an issue that affects the whole community.
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S7 Airlines, a oneworld® global airline alliance member, launches direct scheduled flights from St. Petersburg to Perm starting 30 April 2018. Tickets are available now.
Flights from Pulkovo Airport to Perm will be carried out on Mondays, Wednesdays and Fridays. Flights will depart from Pulkovo Airport at 19:05 and arrive in Perm at 23:25 local time. Return flights will be carried out on Tuesdays, Thursdays, and Saturdays. Flights will depart from Perm at 00:20 and arrive in St. Petersburg at 01:00. The flights will be carried out on modern and comfortable Airbus A319 aircraft.
"We are glad to offer our passengers a new flight from St. Petersburg to Perm as a part of the development of the flight programme from Pulkovo Airport in St. Petersburg. I am sure that flights to Perm, one of the largest economic centres in Russia, will be in demand for business trips as well as for personal travel. Scheduled flights of S7 Airlines to Perm from Moscow and Novosibirsk are traditionally in demand among our passengers," notes Igor Veretennikov, the Commerce Director of S7 Group.
Now, passengers from Perm will be able to fly directly to St. Petersburg or to continue their journey through the Russian and Western European cities of the route network of S7 Airlines with convenient connections at Pulkovo Airport. The entire trip is booked as a single ticket and the baggage is registered straight to the airport of the final destination, which is a great advantage to passengers.


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Neritona (common name: nerite snails), is a genus of small aquatic snails with an operculum, marine, brackish water, and sometimes freshwater gastropod mollusks in the family Neritidae, the nerites.

Species
Species in the genus Neritona include:
 Neritona granosa (G. B. Sowerby I, 1825)
 Neritona juttingae (Mienis, 1973)
 Neritona labiosa (G. B. Sowerby I, 1836)
 Neritona macgillivrayi (Reeve, 1855)
 Neritona melanesica Riech, 1935
 Neritona planissima (Mousson, 1869)
Species brought into synonymy
 Neritona latissima (Broderip, 1833): synonym of Clypeolum latissimum (Broderip, 1833)
 † Neritona martensi Brusina, 1884: synonym of † Theodoxus martensi (Brusina, 1884)

References

External links
 Martens, E. von. (1869). [Über die Deckel der Schneckengattungen Neritina, Nerita, und Navicella. Sitzungsberichte der Gesellschaft naturforschender Freude zu Berlin. 1869: 21-23]
 Gray, J. E. (1847). A list of the genera of recent Mollusca, their synonyma and types. Proceedings of the Zoological Society of London. (1847) 15: 129-219
 Benson, W. H. (1856). Descriptions of three new species of Paludomus from Burmah, and of some forms of Stenothyra (Nematura) from Penang, Mergui, etc. Annals and Magazine of Natural History, Series 2. 17(102): 494-504
 Martens, E. von. (1863-1879). Die Gattung Neritina. In: Küster, H. C.; Kobelt, W., Weinkauff, H. C., Eds. Systematisches Conchylien-Cabinet von Martini und Chemnitz. Neu herausgegeben und vervollständigt. Zweiten Bandes zehnte Abtheilung. 1-303, pls A, 1-23. Nürnberg: Bauer & Raspe.

Neritidae


This letter, signed by more than 130 Muslim clerics and delivered to Pope Benedict is, on the surface, a "peace" gesture. Maybe these clerics are the "good" guys, standing up to the fanatic killers who speak in the name of their religion. But maybe they are also following a millennia-old pattern of Muslims who argue for a temporary truce or even for "peace" but only as a way of positioning themselves more securely for a military and religious victory.
I have asked a number of Islamic scholars to de-code this letter for me. I welcome your views as well.
Please read it in full.
I of course wonder why the Chief Rabbis of Israel were not included. Can this possibly mean that such an imagined "peace" will not include Jews or Israel, that it will only be a Muslim-Christian kinda thing? Buddhists, Hindus, Confucians, and other non-Christians religions are not included either.
What can this all mean? Stay tuned.


The shop department of the Iron Workers organizes and bargains for thousands of employees who work for the approximately 500 employers in the steel fabrication and related industries. Like the rest of the Iron Workers, the shop department operates in both the United States and Canada.
The shop department offers employees as well as their employers the opportunity to participate in the National Shopmen's Pension Plan, the Canadian National Shopmen's Pension Plan and a National Health Care Plan managed by IMPACT.
In conjunction with the organizing department, the shop department continuously conducts aggressive campaigns to organize those who need a voice in the workplace so that they will have higher wages, pensions, health plans and greater respect from employers. In addition to local union representation throughout the U.S. and Canada, the Iron Workers have representatives who stand ready to assist unorganized workers in all organizing campaigns. These efforts safeguard the Iron Workers' jurisdiction while improving the standard of living for the entire membership.
If you're not currently a member of the Iron Workers, but work in the steel fabrication or related industries, you can apply to have the Iron Workers help you organize your workplace.