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text:
Tune into Others & Practice Empathy - Rick Hanson
From greatergood.berkeley.edu - May 24, 2011 12:54 PM
Empathy is the bedrock of our relationships with others, says Rick Hanson. Here's how to practice it.
This post's practice—empathy—knits human beings together, and is at the heart of healthy relationships. You were born with this capability—consider that babies cry when they hear other babies cry, but not at recordings of their own crying—and you can get better at it with practice.
Why? Imagine a world in which people interacted with each other like ants or fish. Imagine a day at work like this, or in your family, aware of the surface behavior of the people around you but oblivious to their inner life, while they remain unmoved by your own. That's a world without empathy. To me, it sounds like a horror film.
More at Empathy Experts: Rick Hanson
http://cultureofempathy.com/References/Experts/Rick-Hanson.htm
Your Brain, Mindful Presence and Five Practices to Energize Love In Your Relationship, 2 of 2 | Neuroscience and Relationships
From blogs.psychcentral.com - May 22, 2011 5:07 PM
Emotions of love and compassion give meaning and purpose to life. The brain is wired with circuitry for caring and empathic connection...
You want happiness? The best option is to grow your ability to empathically connect to your self and partner, in present moments of awareness. It's a way of knowing, understand your self, and life around you that is connected to your compassion, and that allows you to best understand and empathically connect to your partner. Athena Staik
Licia Freeman's curator insight, November 7, 2013 9:24 AM
Connecting brains?
West Wing Star Rob Lowe: Conservative politics is based on "logic." Liberalism, is "built on empathy"
From www.newsbusters.org - May 20, 2011 12:54 PM
Lowe: I think that artists build their art around empathy. I think that liberal politics is built on empathy. I think conservative politics, from my opinion is built on-
Hannity: Common sense?
Lowe: Logic. Logic and empathy it's like left brain, right brain stuff. So I just think naturally empathetic artists are drawn to that.
Compassion Project celebrated in event at Fox Cities Performing Arts Center in Appleton - (video 2hr)
From www.postcrescent.com - May 19, 2011 1:36 PM
An inspirational presentation celebrating compassion through science art and music with Dr. Richardson Davidson, Center for Investigating Healthy Minds (UW-Madison), Appleton North Choir, and singer-songwriter Cory Chisel. Free general admission; tickets are available at The Trout Museum of Art, the Fox Cities Performing Arts Center, and the Appleton Education Foundation.
http://www.troutmuseum.org/compassion-live.htm
Tuesday's celebration was presented by the Appleton Education Foundation in partnership with Trout and the Appleton Area School District as part of AEF's 2011 Community Education Program.
Dr. Richard Davidson toured the Trout Museum of Art on Tuesday, drinking in the spectacle of row upon row of 6-by-6-inch panels —more than 10,000 of them.
All had been contributed by Appleton school children for the Compassion Project, and on those tiles were the students' drawings and paintings of what compassion means to them.
The Power of Empathy and Compassion: "Empathy is a quality of Character that can Change the World" says Obama.
From musings-ems.blogspot.com - May 18, 2011 2:33 PM
Speaking at the National Hispanic Prayer Breakfast on May 12th 2011 Obama said that empathy is a source of morality in the immigration reform debate. According to Edwin Rutsch, writing to Members in Let's Find 1 Million People Who Want to Build a Culture of Empathy and Compassion, Obama has been talking about empathy and compassion more lately and Edwin thinks it will be central to his 2012 election campaign.
Here is the video posted up as part of Edwin Rutsch's empathy documentary project. where you will find links to many other videos from Obama and others on the importance of empathy.
The empathy scale: where does your child fit in?
From www.thenational.ae - May 18, 2011 1:13 AM
As you watch your six-year-old daughter having a tantrum because she lost her favourite hair slide, it's easy to wonder: where does that rage come from? And where might it lead? Equally, when you watch her blithely crush snails underfoot or deliberately pinch her little brother, you find yourself thinking: how come she is so apparently unfeeling? Is it something we, as parents, have done?
Rare is the parent with a child so saintly that she has never asked herself these questions. But there is little need to worry. Young children get angry. They jump on snails and squash flies
Is Your Empathy Killing Your Career?
From www.cnbc.com - May 17, 2011 2:14 PM
The Dark Side of Empathy by Barbara Oakley, the author of Cold-Blooded Kindness: Neuroquirks of a Codependent Killer, or Just Give Me a Shot at Loving You, Dear, and Other Reflections on Helping that Hurts.
Empathy, altruism, and caring for others has become the mantra of modern American culture, but as the Greg Mortenson scandal over his three cups of deceit has revealed—empathy has a dark side that has remained unexplored...
Empathy's dark side has been too long neglected. To truly help others, it's time to shine a light into the darkness. Barbara Oakley
Empathy's Decline University of Michigan - David Brooks
From brooks.blogs.nytimes.com - May 27, 2011 9:44 PM
Nonetheless there is troubling evidence. Scientific American recently reported on research by Sara H. Konrath of the University of Michigan. She looked at surveys in which students were asked to rate their own empathy. She found that self-reported empathy has declined sharply over the past decade. Almost 75 percent of the students today rate themselves as less empathetic than the average student 30 years ago.
The Empathy Issue - NY Times
From www.nytimes.com - May 27, 2011 9:49 PM
The crucial question in evaluating a potential Supreme Court justice, therefore, is not whether she relies on empathy or emotion, but how she does so. First, can she process multiple streams of emotion? Reason is weak and emotions are strong, but emotions can be balanced off each other. Sonia Sotomayor will be a good justice if she can empathize with the many types of people and actions involved in a case, but a bad justice if she can only empathize with one type, one ethnic group or one social class.
Second, does she have a love for the institutions of the law themselves? For some lawyers, the law is not only a bunch of statutes but a code of chivalry. The good judges seem to derive a profound emotional satisfaction from the faithful execution of time-tested precedents and traditions.
It's not whether judges rely on emotion and empathy, it's how they educate their sentiments within the discipline of manners and morals, tradition and practice.
David Brooks
Bishop Fulton Sheen on False Compassion(Part I)
From www.youtube.com - May 16, 2011 7:19 PM
Bishop Sheen on False and True Compassion.
[I try to show all different views of compassion and empathy here. Fulton does a good job of articulating this point of view which is more of the conservative view.]
Channel your inner chimp and let a little empathy show
From www.timescolonist.com - May 15, 2011 11:15 AM
A study published last month in the journal Social Psychology and Personality Science found that someone with a permanent poker face caused by Botox can't mirror a joyful smile or a furrowed brow -and this mimicry, research suggests, is essential to our capacity to empathize with others.
A frozen face begets frozen feelings.
This got us thinking about empathy. We can't afford to forfeit it for taut skin. It takes about 40 muscles to frown -and we'd like to preserve every one of them.
Cambridge University psychologist Simon Baron-Cohen writes that empathy is already in short supply in this warring world.
img http://bit.ly/jpbbCV
Exploring Empathy: Simon Baron-Cohen, Gwen Adshead, Julian Baggini, Val McDermid: podcast
From earideas.com - May 14, 2011 6:20 PM
Andrew Marr explores how far empathy, or the lack of it, can explain cruelty. Simon Baron-Cohen proposes turning the focus away from evil and says we should understand human behaviour by studying the 'empathy circuit' in the brain.
Gwen Adshead, a forensic psychotherapist at Broadmoor Hospital and the crime writer Val McDermid question whether this would help in their line of work, and the philosopher Julian Baggini tries to pin down what we mean when we talk about the self.
with transcripts of this show.
The Empathy Symbol: a symbol for today
From www.empathysymbol.com - May 14, 2011 6:47 PM
The Empathy Symbol stands for reaching out to the "other" and then opening up to truly understand each other. Use the empathy symbol to indicate your support for a world in which we all can get along.
The Power of Presence and How You Relate – Love or Fear? Athena Staik 1of2
Your presence has power. You have a built-in ability to create happiness in your life and relationships, and the quality of your presence is the substance that builds trust.
Actions that stem from being present convey a sense of connection to your self and those you love. Perhaps more importantly, presence sends a message that affirms your commitment in key relationships, energizing good feelings that cause your brains to release Oxytocin, a hormone linked to felt sense of safety, love and connection.
ASHOKA U.S. Empathy Leader Job Opening
From www.idealist.org - May 21, 2011 12:42 PM
The world is changing—faster than ever before—from a society run by elites to one in which everyone can be a changemaker. Ashoka has come to believe that empathy is one of the most important issues of our time: the 21st Century skill fundamental to all the rest, from innovation and teamwork to leadership and changemaking. Empathy is the heart of the future of growing up.
That's why we're committing historic resources to building a world in which every child masters empathy – and in which all institutions, from elementary schools to large corporations to entire countries, integrate empathy as a core principle and practice. Ashoka imagines the day that all children will be empathic – but it will take an energetic team to make this powerful vision a reality in our time.
Frans de Waal talks with Edwin about the Nature of Empathy - video
My interview with the noted primateologist and author of Age of Empathy, Frans de Waal. I asked. "How can we build a culture of empathy?"
I think it is important in society, especially at the moment. Now that we have come out of this period where greed was so good. I think it is important to emphasize that there are alternative ways of looking at society. A society where solidarity is important and caring about others is important.
The other things, that I'm not an expert on, is education and culture of course. A cultural and educational change that emphasizes empathy more. I would also warn that empathy is not invariably positive. People think that empathy is automatically a positive characteristic. Empathy can be used for bad purposes also.
Hitler Suffers 'Empathy Erosion' as Killers Become Victims: George Walden
From www.bloomberg.com - May 19, 2011 11:32 AM
Do you sigh for a world without evil? A place where criminals are conscience-stricken and altruistic folk of all nations sit down together to make peace? ..
And what about people whose flamboyant empathy is in truth a form of self-gratification? What of pop stars who are keen on giving foreign aid to countries where the money ends up in the bank accounts of ministers almost as rich as the (occasionally tax-dodging) performers themselves?
No Responsibility? More seriously, what happens when the notion of human responsibility for evil goes out of the window, along with the very concept of evil? In Baron-Cohen's world, murderers, rapists and villainous statesmen lack empathy for genetic and environmental reasons.
img http://bit.ly/iqqrTc
Looking for Empathy in a Conflict-Ridden World
From www.scientificamerican.com - May 18, 2011 1:30 PM
This, I believe, is empathy (though, as I've recently discovered, scientists can't seem to agree on their own definition). We've all "felt" for someone else, whether that person is a stranger getting slapped in public or a close friend suffering through the loss of a pet. The empathy we experience can feel as real as if the pain were our own.
But empathy is failing on a pretty mass scale. It fails between Christians and Muslims. It fails between Israelis and Palestinians. Between Democrats and Republicans. Between Red Sox and Yankees fans. When it comes to conflict groups, empathy largely goes offline.
Libertarians and Compassion | The Agitator
From www.theagitator.com - May 17, 2011 3:03 PM
Are the two compatible?
I ask this question not because I think that libertarians are lacking a basic human emotion (I don't believe you are), but because politically, I think it needs explanation if libertarian thought is going to be able to reach a larger audience.
Let me explain….when reading a recent interview that Brian Dougherty from Reason did with Ron Paul, Paul said: The biggest challenge for conservatives and libertarians is to convince people who think being libertarian means you have no compassion, and in politics you better have compassion.
Nice Guys Finish First - By David Brooks - NY TImes
From www.nytimes.com - May 17, 2011 11:17 AM
Developments in the study of evolution suggest that the survival of the fittest depends as much on cooperation as it does on a competition between self-interests.
These are books about sympathy, empathy, cooperation and collaboration, written by scientists, evolutionary psychologists, neuroscientists and others. It seems there's been a shift among those who study this ground, yielding a more nuanced, and often gentler picture of our nature.
The Spirit of Sympathy - NYTimes.com
The use of reconciliation threatens to destroy the humanizing function of the Senate.
Human beings, the philosophers tell us, are social animals. We emerge into the world ready to connect with mom and dad. We go through life jibbering and jabbering with each other, grouping and regrouping. When you get a crowd of people in a room, the problem is not getting them to talk to each other; the problem is getting them to shut up.
To help us in this social world, God, nature and culture have equipped us with a spirit of sympathy. We instinctively feel a tinge of pain when we observe another in pain
The Social Animal - New York Times columnist David Brooks
Acclaimed New York Times columnist David Brooks explores new insights into human nature and the forces that shape our choices and actions
1. 98% of experience is unconsciousness
2. emotions is the foundation of reason. it assigns value to experience.
3. not individual creatures but tightly interpenetrated with others
We are primarily social creatures an not rational creatures
This changes our view of politics
Important traits;
1. Mindsite - see into other peoples minds and download what they have to offer. We learn by mimicry.
2. Equipoise - able to see into ones self and correct for bias's
3. Metas - look at environment and see patterns
sympathy - scan a social environment
Bishop Fulton Sheen on False Compassion(Part II)
[I try to show all different views of compassion and empathy here. Fulton does a good job of articulating this point of view.]
The limits of feeling someone else's pain
From www.cbc.ca - May 14, 2011 10:32 PM
Richard Handler on the tyranny of empathy.
Everywhere I turn these days I see paeans to empathy. Books are being written about its civilizing powers — The Empathic Civilization, Empathy and Democracy, Empathy in a Global World — and conferences and websites are being devoted to the concept as well.
In his bid for the presidency, Barack Obama literally ran his campaign on the value of being emotionally open, telling Americans they had, in fact, an "empathy deficit," which he urged they rectify, first by electing him.
Empathy, of course, is the ability to experience the feelings of another person. Humans do it, so do other mammals, according to many primatologists, including Frans de Waal, author of Our Inner Ape and The Age of Empathy.
'Empathy? Compassion? I have medication for that.'
From www.cartoonstock.com - May 14, 2011 3:08 PM

redpajama_set_name: RedPajamaCommonCrawl


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Product prices and availability are accurate as of 2019-04-25 19:07:16 EDT and are subject to change. Any price and availability information displayed on http://www.amazon.com/ at the time of purchase will apply to the purchase of this product.
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text:
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defined('BASEPATH') OR exit('No direct script access allowed');

class MY_Loader extends CI_Loader
{
    public function loadWidget($widget) {
        $data = null;

        $filePath = "application/models/widgets/" . $widget . ".php";
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redpajama_set_name: RedPajamaGithub


text:
Inmate Flees Waterloo Halfway House
Troy Stewart / Courtesy: Iowa Department of Corrections
For the second time this week, an inmate serving time for felony domestic assault has fled a halfway house in Waterloo.
According to officials with the Iowa Department of Corrections, 40-year-old Troy Stewart failed to report back to the Waterloo Residential Correctional Facility Thursday night following a work release assignment. He's now considered an escapee.
Court records show that Stewart was admitted to the work release facility on March 10 after being convicted of felony domestic abuse assault and other crimes in Black Hawk County.
Courtesy: Iowa Dept. of Corrections
Earlier this week, corrections officials reported that 31-year-old Cody Tarrance failed to return from his Monday work release assignment. Court records indicated that he still had not returned as of Friday, with documents listing him as "out of custody".
Tarrance is described as a white man, who's about 5'11" and 205 pounds. Stewart is described as a white man, who's about 5'7" and 244 pounds.
Anyone with information on the whereabouts of Tarrance or Stewart should contact local police.
Filed Under: Black Hawk County, Crime, Waterloo


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Software developers, driven by the speed and scope of the Internet, have never felt greater pressure to produce. Tim Landgrave outlines his software development protocol to help meet this need for speed. He calls the process Q2: Quality Software Quickly.
Developing Software Quickly: How to use the Q2 system
by eadvantage in CXO
on September 7, 2000, 12:00 AM PDT
Before the PC revolution began—when computing resources were expensive and shared—developing optimal software systems took months and sometimes years.
That time frame changed when the PC and Microsoft Windows became the default development platform for corporations. Developing software that optimized the available resources was accelerated by development managers who promised that Rapid Application Development (RAD) systems using products like Visual Basic, PowerBuilder and SQL Windows would allow IT departments to roll out applications quickly.
Because we are now on "Internet time" we have to be able to quickly develop and deploy Web sites and Web-based applications that connect to existing back-end systems.
What's interesting about all of this is that the basics of software development really haven't changed.
Sure, the tools have changed and the scope has gone from hundreds of users (mainframes) to tens of users (PCs and networks) and now millions of users (the Internet). Despite tremendous expansion and new development tools, successful projects still require a balance of three fundamental variables: features, schedule and resources.
During the mainframe era, most development shops chose to maximize resources. PC developers, given the robust nature of their new development platform, chose to maximize features. The time demands of the Internet age virtually require companies to continually update their platforms and applications to meet the needs of their customers.
During the next three weeks we'll look at what your development staff needs to focus on to develop Quality Software Quickly, a process Tim Landgrave has termed Q2 Development. Next week, we'll look at making sure developers produce what customers want. We'll also outline steps to ensure the process and the products are properly tested.
In order to do this, the schedule has to be the most important variable.
Focusing on the schedule
To undertake a Q2 development initiative you must first agree to make default assumptions for all development projects. All developers should agree to abide by a simple set of rules and requirements to ensure your success:
All product development timelines consist of three phases: definition, development and delivery. These can be further subdivided to produce a product vision and specifications during the definition phase. The development phase is composed of code development and code completion. The delivery phase includes platform testing and product rollout.
Complete each phase in sequence. Each phase has specific deliverables that must be complete before moving on to the next phase.
All product development timelines are fixed at a specific number of weeks or months. For our projects, we use three months—one month each for definition, development and delivery. By their nature, all Q2 products are fully developed by repeating these phases and successively adding or completing the features of the product.
You should never consider a Q2 product to be "done." You are only releasing a product at a particular level, assuming that additional features will be added when resources allow.
Managers of Q2 projects will sacrifice features or add resources to make schedules. If the product is de-featured to the point where it's no longer useful or where the resources required to produce the product become too expensive, then the definition phase needs to be revisited (using checkpoints).
Each phase includes a mid-phase checkpoint where senior managers make a decision on the fate of the product.
Definition phase mid point: After developing the product vision, managers make a go vs. no-go decision. It's much less expensive to kill a project at this point than to spend time and resources developing specifications and applying development resources to a project that lacks vision or direction.
Development phase mid point: Senior management has to make a feature vs. resource decision. If there are features that have to be implemented but cannot, given the existing resources, then resources have to be added. More often than not, however, the decision will be made to reduce or eliminate features in order to meet fixed resource or scheduling requirements.
Delivery phase mid point: You are now faced with a resource vs. schedule decision. If all the features haven't been properly tested, then moving into a product rollout phase is foolish. Now the decision is whether to apply additional testing resources or to extend the testing period with existing resources. The only time you should be willing to sacrifice schedule is to ensure quality by completing the proper testing before deployment finishes.
Agree on a standard set of tools. To make these aggressive schedules, you have to decide on a standard set of tools and platform software. For example, if you're a Microsoft shop you may make the following assumptions:
All systems will be developed using Microsoft Visual Studio as the development toolset.
The server platform will consist of Microsoft .NET Servers (Windows 2000 Advanced Server, SQL Server 2000, Exchange 2000, Internet Security and Acceleration Server 2000, Application Center 2000, Commerce Server 2000, and BizTalk Server 2000).
The supported desktop platform will be one or more of the following: Windows 32 applications, HTML 3.2 compatible browsers and Internet Explorer 5.0 and higher. Desktop platform selection depends on the audience and the skill set of the developers assigned to the project.
If you're a pure UNIX shop, then you'll have a similar set of core development standards. It's likely that your development shop will include a mix of development tools and platforms.
Define the reference platform. In addition to defining the platform and tools for development, you'll also have to design applications to run on a standard reference platform. The reference platform defines standards for major development areas including security, data access, physical architecture, licensing standards, etc.
You should define, develop, and deliver the reference platform just like any other product. All products should then reference the version of the reference platform on which they're architected to run.
What do you do to ensure that projects are being completed on time? How do you meet quality standards? Post your comments below or send us an e-mail.
eadvantage
Published: September 7, 2000, 12:00 AM PDT Modified: June 8, 2007, 9:07 AM PDT See more CXO
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text:
require File.dirname(__FILE__) + '/../spec_helper'

describe KeepAlivedConfigFile::Parser, "parsing" do
  before(:all) do
    @parser = KeepAlivedConfigFile::Parser.new
  end

  describe "keepalived.conf as input" do
    before(:all) do
      @result = @parser.parse(File.read(File.dirname(__FILE__)+'/../fixtures/keepalived.conf'))
      # pp @parser
      # raise ArgumentError
    end
    it "shouldn't be nil" do
      @result.should_not be_nil
    end
    it "should return a kind of KeepAlivedConfigFile::Grammar::ConfigFile" do
      @result.should be_a_kind_of(KeepAlivedConfigFile::Grammar::ConfigFile)
    end

    describe "evaluated output" do
      before(:all) do
        @evaluated_result = @result.eval
        # pp @evaluated_result
      end
      it "should return a hash of the evaluated string" do
        @evaluated_result.should be_a_kind_of(Hash)
      end
    end
  end
end


text:
CARSON HENLEY: 100 Hours (www.carsonhenley.com)
Carson Henley hails from Seattle where he's part of a big musical family. His mother was a professional musician and his sister – Tess – has already made a name for herself with a couple of subtle, understated soul and smooth jazz sets (check 'em out in our reviews archive). Though it has its own subtlety, Carson's music is much more direct than his sister's. It's not quite in your face but it has a rock element quite missing from Tess's work. Asked to describe it I'd put it in the same bag as Hall and Oates and Robin Thicke though in places I can also hear the influence of bands like The Eagles while the opening cut, 'Ain't Gonna Dry Yours Tears' seems to borrow heavily from Ace's pop classic 'How Long'. Fans of that kind of pop will love tracks here like the bright 'Give It Up', the catchy 'Fire' and the rolling 'Where We Started'.
Soul fans will be more impressed by the set's only ballad – the dramatic 'Leave This Mess'. It's a well-constructed song with a simple, stark production that underlines the tune's inherent bleakness. It's easily the best track amongst the 7 offerings; that paucity gives the set all the feel of a sampler … and if you want to sample some of it go to www.carsonhenley.com


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"Starboy" Track List: Check out the Weeknd's New Album, & Title Track
By: Elena Nicosia - Published: September 22, 2016 at 1:18 pm
Photo: Splash News
Abel Tesfaye, also known as The Weeknd, has released the title track to his upcoming album today and fans are already loving it! The Weeknd's new album has the same name as the Weeknd's new song, and fans of the R&B singer are excited to hear he is teaming up with Daft Punk for the track. The Weeknd is known for his unique, mellow sound so fans are searching for "Starboy" lyrics, "Starboy" listen, Starboy track list. Here's what you need to know about the new song and album!
A Two-Month Wait
Fans who want to listen to the Weeknd's new song can get the "Starboy" stream from Apple Music or Spotify. The "Starboy" download is in high demand, so unless you want to wait for it to play on the radio, buying the song from iTunes is the best option. The new album launches November 25th, so fans can listen to the title track until the 18-song record hits stores! Unfortunately, the track list is still kept under wraps. The only two songs available are "False Alarm" and "Starboy" (ft. Daft Punk). Although the wait is long; fans are sure this album is going to be well worth it. With the Weeknd's past career success, there's really no doubt it will be great!
Fans can also pre-order the album and check out the single at The Weeknd's website.
ALBUM PRE ORDER AND SINGLE : STARBOY FT. DAFT PUNK: https://t.co/LZqp1rFBnd pic.twitter.com/bjMA1QG4mK
— The Weeknd (@theweeknd) September 22, 2016
More Explicit Lyrics
The lyrics to "Starboy" are riddled with profanities, not unlike most of The Weeknd's songs. Radio edits catch most of them, but here's a glimpse of what you're in for:
"Let a ni**a Brad Pitt
Legend of the fall took the year like a bandit
Buy my ma a crib and a brand new wagon
Now she hit the grocery shop looking lavish
Star Trek roof in that Wraith of Khan
Girls get loose when they hear this song"
Already Topping the Billboard Charts
Starboy is the Canadian singer-songwriter's third studio album and will be released by XO and Republic Records. It's been just over a year since the singer's last album, Beauty Behind the Madness, which was considered his breakout album. Fans went nuts over his songs, "Often," "The Hills," "In the Night," "Can't Feel My Face" and "Acquainted. "The Hills" and "Can't Feel My Face" both hit the number one spot on the U.S. Billboard Hot 100! "Earned It," also off the album, won an Academy Award and was used as a single on the Fifty Shades of Grey soundtrack. His 2015 album also became the tenth best-selling album of the year, with 1.5 million copies sold across the globe! This is according to the International Federation of the Phonographic Industry. Check out the album yourself in November when it becomes available!
https://goo.gl/h5PjDE
https://goo.gl/erYBFI
https://goo.gl/stwhBp
https://goo.gl/TFIP2T
Comedian Majah Hype Accused of Abusing Girlfriend
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Joan Rule, my grandmother after whom I was inspired to start a blog in the first place, passed away on Friday.
Like the many thousands of families which have a member in the late stages of Alzheimer's Disease, we hope her death was a release. Her mind had left some time ago.
Gran was an incredible influence on my life. She was a yarn spinner, a meticulous diary-keeper, and had a love of great clothes. She also told the same story multiple times. I now do the same, and have discovered this was not a quirk of dementia, but rather a genetic flaw.
Perhaps it's a trait that gets less by generation. My kids could be normal. Maybe.
Anyway, I'm heading back to Horsham for her funeral on Wednesday, hence the hiatus on the blog.
That said, we've not been totally slack.
We're averaging about five houses per weekend. Last weekend we debated over a magnificent renovated cottage in Highgate with grotesque purple carpet and striped wallpaper. I am pretty sure it was the set of Beetlejuice.
Another was a soulless townhouse near the Karrakatta train station. The view of the cemetery was… nice?
Then an old person came and also inspected it.
Also, it had a cat-flap through the wall. On closer inspection, the flap opened to a netted side allyway of the house where a GINORMOUS TABBY CAT stared malcontently at us from one of those cat house scratch-post things. The furry behemoth of a pet was effectively living in a giant netted tent. Presumably this relate to its girth and general distemper.
The Agent was unimpressed, and asked us to not disturb the cat.
It's possible we're failing at house hunting.


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Project acronym 4D-EEG
Project 4D-EEG: A new tool to investigate the spatial and temporal activity patterns in the brain
Researcher (PI) Franciscus C.T. Van Der Helm
Host Institution (HI) TECHNISCHE UNIVERSITEIT DELFT
Summary Our first goal is to develop a new tool to determine brain activity with a high temporal (< 1 msec) and spatial (about 2 mm) resolution with the focus on motor control. High density EEG (up to 256 electrodes) will be used for EEG source localization. Advanced force-controlled robot manipulators will be used to impose continuous force perturbations to the joints. Advanced closed-loop system identification algorithms will identify the dynamic EEG response of multiple brain areas to the perturbation, leading to a functional interpretation of EEG. The propagation of the signal in time and 3D space through the cortex can be monitored: 4D-EEG. Preliminary experiments with EEG localization have shown that the continuous force perturbations resulted in a better signal-to-noise ratio and coherence than the current method using transient perturbations.. 4D-EEG will be a direct measure of the neural activity in the brain with an excellent temporal response and easy to use in combination with motor control tasks. The new 4D-EEG method is expected to provide a breakthrough in comparison to functional MRI (fMRI) when elucidating the meaning of cortical map plasticity in motor learning. Our second goal is to generate and validate new hypotheses about the longitudinal relationship between motor learning and cortical map plasticity by clinically using 4D-EEG in an intensive, repeated measurement design in patients suffering from a stroke. The application of 4D-EEG combined with haptic robots will allow us to discover how dynamics in cortical map plasticity are related with upper limb recovery after stroke in terms of neural repair and using behavioral compensation strategies while performing a meaningful motor tasks.. The non-invasive 4D-EEG technique combined with haptic robots will open the window about what and how patients (re)learn when showing motor recovery after stroke in order to allow us to develop more effective patient-tailored therapies in neuro-rehabilitation.
Our first goal is to develop a new tool to determine brain activity with a high temporal (< 1 msec) and spatial (about 2 mm) resolution with the focus on motor control. High density EEG (up to 256 electrodes) will be used for EEG source localization. Advanced force-controlled robot manipulators will be used to impose continuous force perturbations to the joints. Advanced closed-loop system identification algorithms will identify the dynamic EEG response of multiple brain areas to the perturbation, leading to a functional interpretation of EEG. The propagation of the signal in time and 3D space through the cortex can be monitored: 4D-EEG. Preliminary experiments with EEG localization have shown that the continuous force perturbations resulted in a better signal-to-noise ratio and coherence than the current method using transient perturbations.. 4D-EEG will be a direct measure of the neural activity in the brain with an excellent temporal response and easy to use in combination with motor control tasks. The new 4D-EEG method is expected to provide a breakthrough in comparison to functional MRI (fMRI) when elucidating the meaning of cortical map plasticity in motor learning. Our second goal is to generate and validate new hypotheses about the longitudinal relationship between motor learning and cortical map plasticity by clinically using 4D-EEG in an intensive, repeated measurement design in patients suffering from a stroke. The application of 4D-EEG combined with haptic robots will allow us to discover how dynamics in cortical map plasticity are related with upper limb recovery after stroke in terms of neural repair and using behavioral compensation strategies while performing a meaningful motor tasks.. The non-invasive 4D-EEG technique combined with haptic robots will open the window about what and how patients (re)learn when showing motor recovery after stroke in order to allow us to develop more effective patient-tailored therapies in neuro-rehabilitation.
Project acronym AAATSI
Project Advanced Antenna Architecture for THZ Sensing Instruments
Researcher (PI) Andrea Neto
Summary The Tera-Hertz portion of the spectrum presents unique potentials for advanced applications. Currently the THz spectrum is revealing the mechanisms at the origin of our universe and provides the means to monitor the health of our planet via satellite based sensing of critical gases. Potentially time domain sensing of the THz spectrum will be the ideal tool for a vast variety of medical and security applications. Presently, systems in the THz regime are extremely expensive and consequently the THz spectrum is still the domain of only niche (expensive) scientific applications. The main problems are the lack of power and sensitivity. The wide unused THz spectral bandwidth is, herself, the only widely available resource that in the future can compensate for these problems. But, so far, when scientists try to really use the bandwidth, they run into an insurmountable physical limit: antenna dispersion. Antenna dispersion modifies the signal's spectrum in a wavelength dependent manner in all types of radiation, but is particularly deleterious to THz signals because the spectrum is too wide and with foreseeable technology it cannot be digitized. The goal of this proposal is to introduce break-through antenna technology that will eliminate the dispersion bottle neck and revolutionize Time Domain sensing and Spectroscopic Space Science. Achieving these goals the project will pole vault THz imaging technology into the 21-th century and develop critically important enabling technologies which will satisfy the electrical engineering needs of the next 30 years and in the long run will enable multi Tera-bit wireless communications. In order to achieve these goals, I will first build upon two major breakthrough radiation mechanisms that I pioneered: Leaky Lenses and Connected Arrays. Eventually, ultra wide band imaging arrays constituted by thousands of components will be designed on the bases of the new theoretical findings and demonstrated.
The Tera-Hertz portion of the spectrum presents unique potentials for advanced applications. Currently the THz spectrum is revealing the mechanisms at the origin of our universe and provides the means to monitor the health of our planet via satellite based sensing of critical gases. Potentially time domain sensing of the THz spectrum will be the ideal tool for a vast variety of medical and security applications. Presently, systems in the THz regime are extremely expensive and consequently the THz spectrum is still the domain of only niche (expensive) scientific applications. The main problems are the lack of power and sensitivity. The wide unused THz spectral bandwidth is, herself, the only widely available resource that in the future can compensate for these problems. But, so far, when scientists try to really use the bandwidth, they run into an insurmountable physical limit: antenna dispersion. Antenna dispersion modifies the signal's spectrum in a wavelength dependent manner in all types of radiation, but is particularly deleterious to THz signals because the spectrum is too wide and with foreseeable technology it cannot be digitized. The goal of this proposal is to introduce break-through antenna technology that will eliminate the dispersion bottle neck and revolutionize Time Domain sensing and Spectroscopic Space Science. Achieving these goals the project will pole vault THz imaging technology into the 21-th century and develop critically important enabling technologies which will satisfy the electrical engineering needs of the next 30 years and in the long run will enable multi Tera-bit wireless communications. In order to achieve these goals, I will first build upon two major breakthrough radiation mechanisms that I pioneered: Leaky Lenses and Connected Arrays. Eventually, ultra wide band imaging arrays constituted by thousands of components will be designed on the bases of the new theoretical findings and demonstrated.
Project acronym ACMO
Project Systematic dissection of molecular machines and neural circuits coordinating C. elegans aggregation behaviour
Researcher (PI) Mario De Bono
Host Institution (HI) MEDICAL RESEARCH COUNCIL
Call Details Advanced Grant (AdG), LS5, ERC-2010-AdG_20100317
Summary Elucidating how neural circuits coordinate behaviour, and how molecules underpin the properties of individual neurons are major goals of neuroscience. Optogenetics and neural imaging combined with the powerful genetics and well-described nervous system of C. elegans offer special opportunities to address these questions. Previously, we identified a series of sensory neurons that modulate aggregation of C. elegans. These include neurons that respond to O2, CO2, noxious cues, satiety state, and pheromones. We propose to take our analysis to the next level by dissecting how, in mechanistic molecular terms, these distributed inputs modify the activity of populations of interneurons and motoneurons to coordinate group formation. Our strategy is to develop new, highly parallel approaches to replace the traditional piecemeal analysis. We propose to: 1) Harness next generation sequencing (NGS) to forward genetics, rapidly to identify a molecular ¿parts list¿ for aggregation. Much of the genetics has been done: we have identified almost 200 mutations that inhibit or enhance aggregation but otherwise show no overt phenotype. A pilot study of 50 of these mutations suggests they identify dozens of genes not previously implicated in aggregation. NGS will allow us to molecularly identify these genes in a few months, providing multiple entry points to study molecular and circuitry mechanisms for behaviour. 2) Develop new methods to image the activity of populations of neurons in immobilized and freely moving animals, using genetically encoded indicators such as the calcium sensor cameleon and the voltage indicator mermaid. This will be the first time a complex behaviour has been dissected in this way. We expect to identify novel conserved molecular and circuitry mechanisms.
Elucidating how neural circuits coordinate behaviour, and how molecules underpin the properties of individual neurons are major goals of neuroscience. Optogenetics and neural imaging combined with the powerful genetics and well-described nervous system of C. elegans offer special opportunities to address these questions. Previously, we identified a series of sensory neurons that modulate aggregation of C. elegans. These include neurons that respond to O2, CO2, noxious cues, satiety state, and pheromones. We propose to take our analysis to the next level by dissecting how, in mechanistic molecular terms, these distributed inputs modify the activity of populations of interneurons and motoneurons to coordinate group formation. Our strategy is to develop new, highly parallel approaches to replace the traditional piecemeal analysis. We propose to: 1) Harness next generation sequencing (NGS) to forward genetics, rapidly to identify a molecular ¿parts list¿ for aggregation. Much of the genetics has been done: we have identified almost 200 mutations that inhibit or enhance aggregation but otherwise show no overt phenotype. A pilot study of 50 of these mutations suggests they identify dozens of genes not previously implicated in aggregation. NGS will allow us to molecularly identify these genes in a few months, providing multiple entry points to study molecular and circuitry mechanisms for behaviour. 2) Develop new methods to image the activity of populations of neurons in immobilized and freely moving animals, using genetically encoded indicators such as the calcium sensor cameleon and the voltage indicator mermaid. This will be the first time a complex behaviour has been dissected in this way. We expect to identify novel conserved molecular and circuitry mechanisms.
Project acronym ACrossWire
Project A Cross-Correlated Approach to Engineering Nitride Nanowires
Researcher (PI) Hannah Jane JOYCE
Host Institution (HI) THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Summary Nanowires based on group III–nitride semiconductors exhibit outstanding potential for emerging applications in energy-efficient lighting, optoelectronics and solar energy harvesting. Nitride nanowires, tailored at the nanoscale, should overcome many of the challenges facing conventional planar nitride materials, and also add extraordinary new functionality to these materials. However, progress towards III–nitride nanowire devices has been hampered by the challenges in quantifying nanowire electrical properties using conventional contact-based measurements. Without reliable electrical transport data, it is extremely difficult to optimise nanowire growth and device design. This project aims to overcome this problem through an unconventional approach: advanced contact-free electrical measurements. Contact-free measurements, growth studies, and device studies will be cross-correlated to provide unprecedented insight into the growth mechanisms that govern nanowire electronic properties and ultimately dictate device performance. A key contact-free technique at the heart of this proposal is ultrafast terahertz conductivity spectroscopy: an advanced technique ideal for probing nanowire electrical properties. We will develop new methods to enable the full suite of contact-free (including terahertz, photoluminescence and cathodoluminescence measurements) and contact-based measurements to be performed with high spatial resolution on the same nanowires. This will provide accurate, comprehensive and cross-correlated feedback to guide growth studies and expedite the targeted development of nanowires with specified functionality. We will apply this powerful approach to tailor nanowires as photoelectrodes for solar photoelectrochemical water splitting. This is an application for which nitride nanowires have outstanding, yet unfulfilled, potential. This project will thus harness the true potential of nitride nanowires and bring them to the forefront of 21st century technology.
Nanowires based on group III–nitride semiconductors exhibit outstanding potential for emerging applications in energy-efficient lighting, optoelectronics and solar energy harvesting. Nitride nanowires, tailored at the nanoscale, should overcome many of the challenges facing conventional planar nitride materials, and also add extraordinary new functionality to these materials. However, progress towards III–nitride nanowire devices has been hampered by the challenges in quantifying nanowire electrical properties using conventional contact-based measurements. Without reliable electrical transport data, it is extremely difficult to optimise nanowire growth and device design. This project aims to overcome this problem through an unconventional approach: advanced contact-free electrical measurements. Contact-free measurements, growth studies, and device studies will be cross-correlated to provide unprecedented insight into the growth mechanisms that govern nanowire electronic properties and ultimately dictate device performance. A key contact-free technique at the heart of this proposal is ultrafast terahertz conductivity spectroscopy: an advanced technique ideal for probing nanowire electrical properties. We will develop new methods to enable the full suite of contact-free (including terahertz, photoluminescence and cathodoluminescence measurements) and contact-based measurements to be performed with high spatial resolution on the same nanowires. This will provide accurate, comprehensive and cross-correlated feedback to guide growth studies and expedite the targeted development of nanowires with specified functionality. We will apply this powerful approach to tailor nanowires as photoelectrodes for solar photoelectrochemical water splitting. This is an application for which nitride nanowires have outstanding, yet unfulfilled, potential. This project will thus harness the true potential of nitride nanowires and bring them to the forefront of 21st century technology.
Project acronym ACTIVE_NEUROGENESIS
Project Activity-dependent signaling in radial glial cells and their neuronal progeny
Researcher (PI) Colin Akerman
Host Institution (HI) THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Summary A significant advance in the field of development has been the appreciation that radial glial cells are progenitors and give birth to neurons in the brain. In order to advance this exciting area of biology, we need approaches that combine structural and functional studies of these cells. This is reflected by the emerging realisation that dynamic interactions involving radial glia may be critical for the regulation of their proliferative behaviour. It has been observed that radial glia experience transient elevations in intracellular Ca2+ but the nature of these signals, and the information that they convey, is not known. The inability to observe these cells in vivo and over the course of their development has also meant that basic questions remain unexplored. For instance, how does the behaviour of a radial glial cell at one point in development, influence the final identity of its progeny? I propose to build a research team that will capitalise upon methods we have developed for observing individual radial glia and their progeny in an intact vertebrate nervous system. The visual system of Xenopus Laevis tadpoles offers non-invasive optical access to the brain, making time-lapse imaging of single cells feasible over minutes and weeks. The system s anatomy lends itself to techniques that measure the activity of the cells in a functional sensory network. We will use this to examine signalling mechanisms in radial glia and how a radial glial cell s experience influences its proliferative behaviour and the types of neuron it generates. We will also examine the interactions that continue between a radial glial cell and its daughter neurons. Finally, we will explore the relationships that exist within neuronal progeny derived from a single radial glial cell.
A significant advance in the field of development has been the appreciation that radial glial cells are progenitors and give birth to neurons in the brain. In order to advance this exciting area of biology, we need approaches that combine structural and functional studies of these cells. This is reflected by the emerging realisation that dynamic interactions involving radial glia may be critical for the regulation of their proliferative behaviour. It has been observed that radial glia experience transient elevations in intracellular Ca2+ but the nature of these signals, and the information that they convey, is not known. The inability to observe these cells in vivo and over the course of their development has also meant that basic questions remain unexplored. For instance, how does the behaviour of a radial glial cell at one point in development, influence the final identity of its progeny? I propose to build a research team that will capitalise upon methods we have developed for observing individual radial glia and their progeny in an intact vertebrate nervous system. The visual system of Xenopus Laevis tadpoles offers non-invasive optical access to the brain, making time-lapse imaging of single cells feasible over minutes and weeks. The system s anatomy lends itself to techniques that measure the activity of the cells in a functional sensory network. We will use this to examine signalling mechanisms in radial glia and how a radial glial cell s experience influences its proliferative behaviour and the types of neuron it generates. We will also examine the interactions that continue between a radial glial cell and its daughter neurons. Finally, we will explore the relationships that exist within neuronal progeny derived from a single radial glial cell.
Project acronym ACTSELECTCONTEXT
Project Action Selection under Contextual Uncertainty: the Role of Learning and Effective Connectivity in the Human Brain
Researcher (PI) Sven Bestmann
Host Institution (HI) UNIVERSITY COLLEGE LONDON
Call Details Starting Grant (StG), LS5, ERC-2010-StG_20091118
Summary In a changing world, one hallmark feature of human behaviour is the ability to learn about the statistics of the environment and use this prior information for action selection. Knowing about a forthcoming event allows for adjusting our actions pre-emptively, which can optimize survival. This proposal studies how the human brain learns about the uncertainty in the environment, and how this leads to flexible and efficient action selection. I hypothesise that the accumulation of evidence for future movements through learning reflects a fundamental organisational principle for action control. This explains widely distributed perceptual-, learning-, decision-, and movement-related signals in the human brain. However, little is known about the concerted interplay between brain regions in terms of effective connectivity which is required for flexible behaviour. My proposal seeks to shed light on this unresolved issue. To this end, I will use i) a multi-disciplinary neuroimaging approach, together with model-based analyses and Bayesian model comparison, adapted to human reaching behaviour as occurring in daily life; and ii) two novel approaches for testing effective connectivity: dynamic causal modelling (DCM) and concurrent transcranial magnetic stimulation-functional magnetic resonance imaging. My prediction is that action selection relies on effective connectivity changes, which are a function of the prior information that the brain has to learn about. If true, this will provide novel insight into the human ability to select actions, based on learning about the uncertainty which is inherent in contextual information. This is relevant for understanding action selection during development and ageing, and for pathologies of action such as Parkinson s disease or stroke.
In a changing world, one hallmark feature of human behaviour is the ability to learn about the statistics of the environment and use this prior information for action selection. Knowing about a forthcoming event allows for adjusting our actions pre-emptively, which can optimize survival. This proposal studies how the human brain learns about the uncertainty in the environment, and how this leads to flexible and efficient action selection. I hypothesise that the accumulation of evidence for future movements through learning reflects a fundamental organisational principle for action control. This explains widely distributed perceptual-, learning-, decision-, and movement-related signals in the human brain. However, little is known about the concerted interplay between brain regions in terms of effective connectivity which is required for flexible behaviour. My proposal seeks to shed light on this unresolved issue. To this end, I will use i) a multi-disciplinary neuroimaging approach, together with model-based analyses and Bayesian model comparison, adapted to human reaching behaviour as occurring in daily life; and ii) two novel approaches for testing effective connectivity: dynamic causal modelling (DCM) and concurrent transcranial magnetic stimulation-functional magnetic resonance imaging. My prediction is that action selection relies on effective connectivity changes, which are a function of the prior information that the brain has to learn about. If true, this will provide novel insight into the human ability to select actions, based on learning about the uncertainty which is inherent in contextual information. This is relevant for understanding action selection during development and ageing, and for pathologies of action such as Parkinson s disease or stroke.
Project acronym AdOMiS
Project Adaptive Optical Microscopy Systems: Unifying theory, practice and applications
Researcher (PI) Martin BOOTH
Summary Recent technological advances in optical microscopy have vastly broadened the possibilities for applications in the biomedical sciences. Fluorescence microscopy is the central tool for investigation of molecular structures and dynamics that take place in the cellular and tissue environment. Coupled with progress in labeling methods, these microscopes permit observation of biological structures and processes with unprecedented sensitivity and resolution. This work has been enabled by the engineering development of diverse optical systems that provide different capabilities for the imaging toolkit. All such methods rely upon high fidelity optics to provide optimal resolution and efficiency, but they all suffer from aberrations caused by refractive index variations within the specimen. It is widely accepted that in many applications this fundamental problem prevents optimum operation and limits capability. Adaptive optics (AO) has been introduced to overcome these limitations by correcting aberrations and a range of demonstrations has shown clearly its potential. Indeed, it shows great promise to improve virtually all types of research or commercial microscopes, but significant challenges must still be met before AO can be widely implemented in routine imaging. Current advances are being made through development of bespoke AO solutions to individual imaging tasks. However, the diversity of microscopy methods means that individual solutions are often not translatable to other systems. This proposal is directed towards the creation of theoretical and practical frameworks that tie together AO concepts and provide a suite of scientific tools with broad application. This will be achieved through a systems approach that encompasses theoretical modelling, optical engineering and the requirements of biological applications. Additional outputs will include practical designs, operating protocols and software algorithms that will support next generation AO microscope systems.
Recent technological advances in optical microscopy have vastly broadened the possibilities for applications in the biomedical sciences. Fluorescence microscopy is the central tool for investigation of molecular structures and dynamics that take place in the cellular and tissue environment. Coupled with progress in labeling methods, these microscopes permit observation of biological structures and processes with unprecedented sensitivity and resolution. This work has been enabled by the engineering development of diverse optical systems that provide different capabilities for the imaging toolkit. All such methods rely upon high fidelity optics to provide optimal resolution and efficiency, but they all suffer from aberrations caused by refractive index variations within the specimen. It is widely accepted that in many applications this fundamental problem prevents optimum operation and limits capability. Adaptive optics (AO) has been introduced to overcome these limitations by correcting aberrations and a range of demonstrations has shown clearly its potential. Indeed, it shows great promise to improve virtually all types of research or commercial microscopes, but significant challenges must still be met before AO can be widely implemented in routine imaging. Current advances are being made through development of bespoke AO solutions to individual imaging tasks. However, the diversity of microscopy methods means that individual solutions are often not translatable to other systems. This proposal is directed towards the creation of theoretical and practical frameworks that tie together AO concepts and provide a suite of scientific tools with broad application. This will be achieved through a systems approach that encompasses theoretical modelling, optical engineering and the requirements of biological applications. Additional outputs will include practical designs, operating protocols and software algorithms that will support next generation AO microscope systems.
Project acronym ALZSYN
Project Imaging synaptic contributors to dementia
Researcher (PI) Tara Spires-Jones
Host Institution (HI) THE UNIVERSITY OF EDINBURGH
Summary Alzheimer's disease, the most common cause of dementia in older people, is a devastating condition that is becoming a public health crisis as our population ages. Despite great progress recently in Alzheimer's disease research, we have no disease modifying drugs and a decade with a 99.6% failure rate of clinical trials attempting to treat the disease. This project aims to develop relevant therapeutic targets to restore brain function in Alzheimer's disease by integrating human and model studies of synapses. It is widely accepted in the field that alterations in amyloid beta initiate the disease process. However the cascade leading from changes in amyloid to widespread tau pathology and neurodegeneration remain unclear. Synapse loss is the strongest pathological correlate of dementia in Alzheimer's, and mounting evidence suggests that synapse degeneration plays a key role in causing cognitive decline. Here I propose to test the hypothesis that the amyloid cascade begins at the synapse leading to tau pathology, synapse dysfunction and loss, and ultimately neural circuit collapse causing cognitive impairment. The team will use cutting-edge multiphoton and array tomography imaging techniques to test mechanisms downstream of amyloid beta at synapses, and determine whether intervening in the cascade allows recovery of synapse structure and function. Importantly, I will combine studies in robust models of familial Alzheimer's disease with studies in postmortem human brain to confirm relevance of our mechanistic studies to human disease. Finally, human stem cell derived neurons will be used to test mechanisms and potential therapeutics in neurons expressing the human proteome. Together, these experiments are ground-breaking since they have the potential to further our understanding of how synapses are lost in Alzheimer's disease and to identify targets for effective therapeutic intervention, which is a critical unmet need in today's health care system.
Alzheimer's disease, the most common cause of dementia in older people, is a devastating condition that is becoming a public health crisis as our population ages. Despite great progress recently in Alzheimer's disease research, we have no disease modifying drugs and a decade with a 99.6% failure rate of clinical trials attempting to treat the disease. This project aims to develop relevant therapeutic targets to restore brain function in Alzheimer's disease by integrating human and model studies of synapses. It is widely accepted in the field that alterations in amyloid beta initiate the disease process. However the cascade leading from changes in amyloid to widespread tau pathology and neurodegeneration remain unclear. Synapse loss is the strongest pathological correlate of dementia in Alzheimer's, and mounting evidence suggests that synapse degeneration plays a key role in causing cognitive decline. Here I propose to test the hypothesis that the amyloid cascade begins at the synapse leading to tau pathology, synapse dysfunction and loss, and ultimately neural circuit collapse causing cognitive impairment. The team will use cutting-edge multiphoton and array tomography imaging techniques to test mechanisms downstream of amyloid beta at synapses, and determine whether intervening in the cascade allows recovery of synapse structure and function. Importantly, I will combine studies in robust models of familial Alzheimer's disease with studies in postmortem human brain to confirm relevance of our mechanistic studies to human disease. Finally, human stem cell derived neurons will be used to test mechanisms and potential therapeutics in neurons expressing the human proteome. Together, these experiments are ground-breaking since they have the potential to further our understanding of how synapses are lost in Alzheimer's disease and to identify targets for effective therapeutic intervention, which is a critical unmet need in today's health care system.
Project acronym AMPHIBIANS
Project All Optical Manipulation of Photonic Metasurfaces for Biophotonic Applications in Microfluidic Environments
Researcher (PI) Andrea DI FALCO
Host Institution (HI) THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS
Summary The current trend in biophotonics is to try and replicate the same ease and precision that our hands, eyes and ears offer at the macroscopic level, e.g. to hold, observe, squeeze and pull, rotate, cut and probe biological specimens in microfluidic environments. The bidding to get closer and closer to the object of interest has prompted the development of extremely advanced manipulation techniques at scales comparable to that of the wavelength of light. However, the fact that the optical beam can only access the microfluidic chip from the narrow aperture of a microscopic objective limits the versatility of the photonic function that can be realized. With this project, the applicant proposes to introduce a new biophotonic platform based on the all optical manipulation of flexible photonic metasurfaces. These artificial two-dimensional materials have virtually arbitrary photonic responses and have an intrinsic exceptional mechanical stability. This cross-disciplinary project, bridging photonics, material sciences and biology, will enable the adoption of the most modern and advanced photonic designs in microfluidic environments, with transformative benefits for microscopy and biophotonic applications at the interface of molecular and cell biology.
The current trend in biophotonics is to try and replicate the same ease and precision that our hands, eyes and ears offer at the macroscopic level, e.g. to hold, observe, squeeze and pull, rotate, cut and probe biological specimens in microfluidic environments. The bidding to get closer and closer to the object of interest has prompted the development of extremely advanced manipulation techniques at scales comparable to that of the wavelength of light. However, the fact that the optical beam can only access the microfluidic chip from the narrow aperture of a microscopic objective limits the versatility of the photonic function that can be realized. With this project, the applicant proposes to introduce a new biophotonic platform based on the all optical manipulation of flexible photonic metasurfaces. These artificial two-dimensional materials have virtually arbitrary photonic responses and have an intrinsic exceptional mechanical stability. This cross-disciplinary project, bridging photonics, material sciences and biology, will enable the adoption of the most modern and advanced photonic designs in microfluidic environments, with transformative benefits for microscopy and biophotonic applications at the interface of molecular and cell biology.
Project acronym ANXIETY MECHANISMS
Project Neurocognitive mechanisms of human anxiety: identifying and targeting disrupted function
Researcher (PI) Sonia Jane Bishop
Summary Within a 12 month period, 20% of adults will meet criteria for one or more clinical anxiety disorders (ADs). These disorders are hugely disruptive, placing an emotional burden on individuals and their families. While both cognitive behavioural therapy and pharmacological treatment are widely viewed as effective strategies for managing ADs, systematic review of the literature reveals that only 30–45% of patients demonstrate a marked response to treatment (anxiety levels being reduced into the nonaffected range). In addition, a significant proportion of initial responders relapse after treatment is discontinued. There is hence a real and marked need to improve upon current approaches to AD treatment. One possible avenue for improving response rates is through optimizing initial treatment selection. Specifically, it is possible that certain individuals might respond better to cognitive interventions while others might respond better to pharmacological treatment. Recently it has been suggested that there may be two or more distinct biological pathways disrupted in anxiety. If this is the case, then specification of these pathways may be an important step in predicting which individuals are likely to respond to which treatment. Few studies have focused upon this issue and, in particular, upon identifying neural markers that might predict response to cognitive (as opposed to pharmacological) intervention. The proposed research aims to address this. Specifically, it tests the hypothesis that there are at least two mechanisms disrupted in ADs, one entailing amygdala hyper-responsivity to cues that signal threat, the other impoverished recruitment of frontal regions that support cognitive and emotional regulation. Two series of functional magnetic resonance imaging experiments will be conducted. These will investigate differences in amygdala and frontal function during (a) attentional processing and (b) fear conditioning. Initial clinical experiments will investigate whether Generalised Anxiety Disorder and Specific Phobia involve differing degrees of disruption to frontal versus amygdala function during these tasks. This work will feed into training studies, the goal being to characterize AD patient subgroups that benefit from cognitive training.
Within a 12 month period, 20% of adults will meet criteria for one or more clinical anxiety disorders (ADs). These disorders are hugely disruptive, placing an emotional burden on individuals and their families. While both cognitive behavioural therapy and pharmacological treatment are widely viewed as effective strategies for managing ADs, systematic review of the literature reveals that only 30–45% of patients demonstrate a marked response to treatment (anxiety levels being reduced into the nonaffected range). In addition, a significant proportion of initial responders relapse after treatment is discontinued. There is hence a real and marked need to improve upon current approaches to AD treatment. One possible avenue for improving response rates is through optimizing initial treatment selection. Specifically, it is possible that certain individuals might respond better to cognitive interventions while others might respond better to pharmacological treatment. Recently it has been suggested that there may be two or more distinct biological pathways disrupted in anxiety. If this is the case, then specification of these pathways may be an important step in predicting which individuals are likely to respond to which treatment. Few studies have focused upon this issue and, in particular, upon identifying neural markers that might predict response to cognitive (as opposed to pharmacological) intervention. The proposed research aims to address this. Specifically, it tests the hypothesis that there are at least two mechanisms disrupted in ADs, one entailing amygdala hyper-responsivity to cues that signal threat, the other impoverished recruitment of frontal regions that support cognitive and emotional regulation. Two series of functional magnetic resonance imaging experiments will be conducted. These will investigate differences in amygdala and frontal function during (a) attentional processing and (b) fear conditioning. Initial clinical experiments will investigate whether Generalised Anxiety Disorder and Specific Phobia involve differing degrees of disruption to frontal versus amygdala function during these tasks. This work will feed into training studies, the goal being to characterize AD patient subgroups that benefit from cognitive training.


The Green Building Council of Australia (GBCA) has endorsed Stockland's master plan for the $5 billion, 2,310 hectare Caloundra South community on the Sunshine Coast, accrediting the project with a 6 Star Green Star – Communities rating, Australia's highest standard for design excellence, economic prosperity, liveability and environmental responsibility.
The highly coveted 6 Star Green Star - Communities rating signifies world leadership in the design of the master plan, which sets the highest possible standards for the community's long-term economic prosperity, 'liveability' and environmental responsibility during, and well after construction is completed and the community is established.
Caloundra South is the largest mixed use development ever undertaken under single ownership in Australia and the largest project ever undertaken by Stockland. The new city will be developed by Stockland over the next three decades and will grow to a similar size and scale to that of Maroochydore, Hervey Bay or Gladstone, and ultimately be home to around 50,000 people.
Stockland Managing Director and CEO, Mark Steinert, said: "Our team on the Sunshine Coast has spent more than four years working with Australia's leading urban planners,environmental scientists and consultants and a large number of local environmental groups on the coast to develop the most detailed master plan for any project we've ever undertaken.
The Green Star Communities rating tool relies on scientific and holistic analysis, which has been peer reviewed and ratified by more than 1,000 industry and sustainable development experts.
Romilly Madew, added: "Stockland has done an outstanding job to formulate a world's best practice approach to water treatment, purification and management and environmental conservation and rehabilitation for its Caloundra South Master Plan, while also demonstrating inspirational thinking around social inclusion that will enhance the 'liveability' of this new community.
Stockland has gone to extraordinary lengths to ensure the community will become a model for social inclusion and environmentally sensitive urban design and development.
More than 700 hectares, nearly one-third of the site, will be rehabilitated from decades of use as a former pine plantation and designated as a conservation area.
New habitats for rare and endangered flora and fauna species will be created with fauna underpasses at every major creek crossing, and fauna overpasses along all major roads.
Installation of the most advanced water reticulation, filtration, storage and treatment system ever installed in any Australian city, which will recycle water, minimise run-off and ensure the protection of the nearby Pumicestone Passage.
Annual environmental reporting will assess the development of the project against stringent water quality and biodiversity measures.
Stockland will establish an environmental education facility and run sustainability awareness programs to promote life-long learning amongst residents and local school children.
A dedicated Caloundra South economic development strategy will target the creation of 19,500 direct jobs, creating long-term local employment opportunities.
Stockland will invest $300 million alone in the first five years of development, creating thousands of local jobs during this first stage of the project.
Using the latest hybrid designs for home and business premises, Stockland will seek to establish a strong community of home-based business entrepreneurs.
Additional business innovation and incubator hubs will further stimulate the emergence of small businesses and boutique enterprises.
The new community will also help to address the under-supply of affordable, new homes on the Sunshine Coast, which has seen rental vacancies recently slip below 1 per cent* over the last 6 months.
Stockland also confirmed that, as part of its $5 billion Caloundra South development, it will make significant investments in essential services for the benefit of all residents on the Sunshine Coast.
In addition to creating much-needed new homes on the Sunshine Coast, Stockland will invest in local roads, stormwater and wastewater infrastructure and create a host of new communities facilities. This will include nine separate sporting grounds, numerous parks and playgrounds and a People's Place and Central Park alongside a new Town Centre.
Stockland has consistently been the Sunshine Coast's biggest private sector investor for the last 11 years, injecting more than $3.2 billion into the local economy through an array of residential, commercial and retirement living developments, including the 1,500 lot Brightwater community at Kawana, Oceanside Health Precinct, and the highly successful, multi-award-winning Bells Reach Residential Community at Bellvista.
Kingsley Andrew added: "We're immensely proud of achieving a 6 Star Green Star – Communities rating for our Caloundra South master plan. We'll repay the confidence that has been shown by the local community and community groups and our many stakeholders in Local, State and Federal Government by delivering a project that exemplifies the finest qualities of environmental stewardship and sustainability, and helps to ensures the future economic prosperity of the Sunshine Coast.
Stockland is planning to commence construction of the Caloundra South community before the end of FY15, with the first settlements expected in FY16, subject to the finalisation of an Infrastructure Agreement with the newly elected Queensland Government.


Boise, Idaho, December 6, 2005 — Pets Best Insurance, a pet insurance company that is a division of General Fire & Casualty Company, today announced a free, easy-to-use pet recovery program for veterinary clients. Pet owners can receive a free, peel-off sticker listing a toll-free number that adheres to a pet tag. This number can be called to match up missing pets with their owners.
The pet recovery program is being administered by Smart ID, an innovative leader in nondatabase recovery of lost pets and personal items through automated phone or Web systems. Pets Best Insurance is offering these free programs in the states of Arizona, Colorado, Georgia, Idaho, Illinois, Iowa, Kansas, Missouri, Oklahoma, Oregon, Texas and Utah. The company anticipates being able to offer the program in 25 states by the end of this year, and all 50 states by the end of 2006.
The program is simple. Any interested pet owners at affiliated veterinary locations offering Pets Best can obtain a free peel-off sticker to place on the pet's tag. The tag sticker contains a unique identifier number and a toll-free number to call (877-PET-LOST). If the pet is ever lost, the finder calls the automated system and is prompted to enter the unique identifier number. When the owner of the lost pet calls into the system and enters the same identifier number, the system finds the match and automatically plays the finder's message and provides their callback number. Custom notification and personalization options, such as "Message Notify" and "Finder Call Forward" are available for convenience, to prevent missed messages regarding a loss, and the need for repeated system callbacks. This process also can be utilized online.
Pets Best Insurance policyholders are provided this same program with additional premium features: a durable coated-plastic tag with the toll-free and identification numbers, as well as a key chain and identity card with the identifier number and instructions to keep for reference should the pet be lost.
Pets Best Insurance free recovery program features immediate protection once the sticker is placed on the tag and it is good for the life of the pet. The program is simple to use, with no registration or annual fee ever required. Privacy and security for pet owners are always ensured, as the pet recovery program utilizes only the locator number, not the pet owner's address and phone number. A 24 hour/seven day automated message center, personalized messages and lost pet posters are also available. Pet owners who request the free pet recovery stickers will receive a no-obligation Pets Best insurance quote for their pet.
Pets Best, headquartered in Boise, Idaho, is a division of General Fire & Casualty Company, which specializes in the agribusiness, livestock and animal-related insurance products. The pet health insurance company provides the most comprehensive insurance plans for bonded pet owners whose pet is a family member. Its insurance plans provide the peace of mind that comes when a pet owner wants "simply the best." Pets Best Insurance takes pride in offering its policyholders fast claims turnaround, highest limits, generous benefits, a variety of deductible options for every budget, and the most personalized customer-satisfaction approach.


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Kuwait to launch 5G network service by mid-June
Source: Xinhua| 2019-05-29 00:57:19|Editor: Mu Xuequan
KUWAIT CITY, May 28 (Xinhua) -- Kuwait will launch 5G service by mid-June, Kuwait's Communication and Information Technology Regulatory Authority (CITRA) announced on Tuesday.
Salem Al-Othaina, chairman and CEO of CITRA, said that CITRA has completed the pilot operation of the fifth-generation networks of telecommunication companies, and is ready for launching the fifth generation commercially by mid-June.
"This service comes in line with the authority's efforts to develop the telecommunications sector in Kuwait to keep abreast of the modern technological development of telecommunications," he said in a statement.
It also comes in line with the recommendations of the International Telecommunication Union (ITU) and international organizations specialized in the technology, he noted.
This will make Kuwait one of the first countries in the world to organize and operate the new technology, he said.
The application of this service will be a great leap for the telecommunications world where speed of internet connection will reach great lengths, he added.
Farmers busy with their work across China
Press conference held in Seou to promote movie "X-Men: Dark Phoenix"
Xinhua sports photo of the week
Fasting month of Ramadan marked in Kolkata, India
People fly kites during Motley Sky festival in Moscow, Russia
In pics: dance group composed of hearing-impaired people in Shanghai
Xi meets representatives of overseas Chinese
Xinhua Headlines: China pushes forward Yangtze River Delta integration
Letter from China's first lady inspires U.S. students to contribute to bilateral ties
Eco-China: Shanghai's Chongming Island on its way to develop world-class ecological island
/ 01. Commentary: Chinese economy, short sellers' nightmare
/ 02. U.S. ambassador to China makes positive remarks about Tibet: FM spokesman
/ 03. Commentary: Trade war, a turning point for China's technological innovation
/ 04. Spotlight: U.S. farm groups want open markets, not gov't aid
/ 05. Russia launches Glonass navigation satellite
In pics: baby giant pandas at "Giant Panda Kindergarten" in Wolong, SW China
In pics: lotus flowers at wetland park in east China's Anhui
Scenery of Wulingyuan Scenic Area in Zhangjiajie
Fork-tailed sunbird flies among flowers in Chongqing


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Jake Tran
Jake Tran is the youngest ever to receive a Black Belt in Krav Maga under John Whitman of Krav Maga Alliance.
Jake Tran also serves as the striking coach for pro MMA fighter, Cisco Isata, since 2011. He has cornered Cisco in his bouts at World Series of Fighting (WSOF), Shogun, and Cage Fury Fighting Championships (CFFC). Cisco is currently the 145 Champion at Shogun and Strike Off. Outside of fighting, Jake also received a Personal Protection Specialist certification under the Executive Protection Institute and became a member of the Nine Lives Associates in 2013.
Krav Maga Instructor
Krav maga level 5 instructor certification
Bas Rutten Fight Club certified instructor
Lead instructor at Pure Performance Martial Arts Center
Trained under Robert Crawford, who has taught world champions, pro fighters, and golden glove winners.
Krav Maga 94 %
Muay Thai 92 %
Boxing 89 %
Meet Other Trainers
Working from home meant we could vary snack and coffee breaks, change our desks or view, goof off, drink on the job, even spend the day in pajamas
Jason Boyer
Guy Irlander
Guy has served in the Israeli Defense force as a sniper and fought in two wars, embarked on numerous tours of duty, and received the prestigious "warriors pin". Guy has experience in instructing Krav Maga/self defense to many different types of students. He is well versed in the craft, bringing stalwart military attitude to high intensity workouts, creating a sense of "unit" for all participants. Guy draws out the best of his clients by constantly challenging you in new ways, fostering their strengths, and fortifying their weaknesses.
Matt Coleman
Matthew Colman started Boxing at the age of 21. In that time, he has trained with two amateur world champions three national Golden Gloves champions. 2 Olympic boxing team members. He has also trained with the former WBC & IBF World welterweight title (Shawn Porter). Matthew has trained with Coach Kenny porter who is a Level 4 USA Boxing Association Trainer, he has work alongside several coaches such as Bruce Babashan and Coach Robert Crawford who are considered to be one of the premier boxing trainers in the Washington, DC area. His students consist of William Joppy Super Middleweight Champion of the World 38-4-1 and the list goes on. Matthew loves the sweet science of boxing and gets his biggest joy in teaching it.


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Napoli vs Barcelona Preview: Where to Watch, Live Stream, Kick Off Time & Team News
Sam Jacot 05 Aug 2019
Napoli will face Barcelona at the Hard Rock Stadium in Miami on Thursday for the first of two friendlies between the sides.
The meeting will be crucial preparation for both clubs with the start of both the Serie A and La Liga campaigns now under two weeks away.
Whilst there is little at stake in this fixture, the Catalan giants will want to put in a dominant display when the sides meet in Miami. It offers a chance for both sides to make tactical tweaks in a scenario where defeat matters little.
Both sides will want to end their pre-season on a high however, and here is what you need to know before the encounter.
When Is Kick Off? Thursday 8 August
What Time Is Kick Off? 00:00 (BST)
Where Is it Played? Hard Rock Stadium
TV Channel/ Live Stream? Premier Sports 1
Referee? TBC
The Barcelona squad is starting to take shape nicely. With crucial targets signed earlier in the summer, Ernesto Valverde has a huge range of talent to pick from.
Lionel Messi is set to return to the action after having an extended break following his involvement with Argentina in the 2019 Copa America. New signing Frenkie de Jong will hope to keep his place in Ernesto Valverde's starting eleven after impressing against Arsenal.
Antoine Griezmann will also be eager to start from the off after featuring against the Gunners in a fairly quiet display.
For Napoli, this will be their sixth pre-season encounter of the summer, and therefore they should be the fitter of the two sides.
Lorenzo Insigne, Arkadiusz Milik and Amin Younes, all scorers for Napoli against Liverpool last month, will want to start as they bid to reach full fitness ahead of the new campaign.
Carlo Ancelotti will look to use the majority of his squad, as he did against Marseille where he made six changes at half-time. However, Piotr Zielinski is one doubt after he pulled out of their most recent friendly with flu. Kalidou Koulibaly is back after his extended break but it is unlikely he will start.
Predicted Lineups
Napoli Meret; Hysaj, Manolas, Maksimovic, Rui; Callejon, Ruiz, Verdi, Younes; Insigne, Milik.
Barcelona Neto; Semedo, Pique, Umtiti, Alba; Rakitic, De Jong, Puig; Messi, Griezmann, Dembele.
Napoli and Barcelona have met just twice in recent years, both in friendlies. Barcelona thrashed the Naples outfit 5-0 back in 2011 with Cesc Fabregas netting his first goal for the club that day.
Napoli dished out some revenge in 2014 in another pre-season fixture, winning 1-0. This will be the first meeting between the two clubs since then.
Both sides lost their first pre-season outings but have since both recovered, with Napoli unbeaten in their last four matches, notably managing a brilliant 3-0 triumph over Champions League winners Liverpool.
Barcelona slumbered to a defeat against Chelsea in their first pre-season fixture but have since recovered well to beat Japanese side Vissel Kobe before turning over Arsenal 2-1 at Camp Nou last time out.
Whilst it's important not to read too much into pre-season form, both sides are starting to find their feet, and the intensity and pace of this week's meeting should be at a higher level.
Here's a look at the last five results of both sides.
Napoli FC Barcelona
Olympique Marseille 0-1 Napoli (4/8) Barcelona 2-1 Arsenal (4/8)
Liverpool 0-3 Napoli (28/7) Vissel Kobe 0-2 Barcelona (27/7)
Napoli 3-3 Cremonese (24/7) Barcelona 1-2 Chelsea (23/7)
Napoli 5-0 FeralpiSalo (19/7) Barcelona 1-2 Valencia (25/5)
Napoli 1-2 Benevento (13/7) Eibar 2-2 Barcelona (19/5)
Whilst Napoli have more minutes under their belt thus far, Barcelona showed signs they were purring into life against Arsenal.
New signings De Jong and Griezmann should feel more comfortable in the shirt with their debuts and the nerves that can bring now out of the way. Messi will also be back in the frame and is expected to feature, meaning the Napoli backline will be in for a testing time.
Napoli will take courage from the fact they have kept back to back clean sheets, but facing Messi, Griezmann, Dembele and Suarez is a different proposition altogether.
Prediction: Napoli 1-3 Barcelona
Frank Lampard Speaks Out on Olivier Giroud Transfer Amid Inter & West Ham Links


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About ACANAYour dog may not roam the wilderness like their ancestors did, but that doesn't mean you shouldn't feed them like they don't. ACANA makes only foods that are rich in meat and protein variety, with wholeprey meat ratios and limited carbohydrates, replacing fast carbs with low glycemic, healthy fruits and vegetables. With a state of art brand new kitchen in Kentucky, all ACANA foods are sourced and made right here in the USA by trusted farmers. With human grade ingredients that typically arrive at the kitchens within 48 hours of harvesting, fresh is the entire basis of ACANA's brand. Ingredients like heritage red meats from the Appalachian ranching country, free run poultry and eggs, wild caught fish from New England, whole fruits and vegetables like Bartlett pears and butternut squash, and locally grown botanicals from Kentucky, ACANA believes the healthiest foods are made here at home in Kentucky, never outsourced. ACANA nourishes your pet's instinct for real, fresh meats and high quality grain-free carbohydrates. It's everything Mother Nature intended, and nothing she did not.
ACANA Wild Atlantic Regional Formula Grain-Free Dry Dog Food, 25-lb bag The ultimate food mimics one that Mother Nature intended. That s why ACANA Wild Atlantic Regional Formula Grain-Free Dry Dog Food is loaded with wild-caught mackerel, herring, r"


Passchendaele is the next volume in the highly-regarded series of books from the best-selling First World War historian Richard van Emden. Once again, using the winning formula of diaries and memoirs, and above all original photographs taken on illegally-held cameras by the soldiers themselves, Richard tells the story of 1917, of life both in and out of the line culminating in perhaps the most dreaded battle of them all, the Battle of Passchendaele. His previous book, The Somme, has now sold nearly 20,000 copies in hardback and softback, proving that the public appetite is undiminished for new, original stories illustrated with over 150 rarely or never-before-seen battlefield images. The author has an outstanding collection of over 5,000 privately-taken and overwhelmingly unpublished photographs, revealing the war as it was seen by the men involved, an existence that was sometimes exhilarating, too often terrifying, and occasionally even fun.


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Q: How to call webservice with self signed certificate from AWS API gateway? My client has an already developed (and frozen) web service which is being secured with self signed certificate. I have configured AWS API gateway to get rid of CORS issue. When I try to call any endpoint of the web service via AWS API gateway, I find HTTP 500 Internal Server error. Until the client web service is made secured with self signed certificate, HTTP based endpoints were accessible via AWS API gateway.
What are ways to still call the web service endpoints?

A: API Gateway will fail on self signed certificates for http(s) backend integrations.
If you use the test functionality on the API GW you will see a error in the logs that it gives on the right about either a SSL Engine Problem or Bad Certificate.
If your backend is already in AWS and fronted by a load balancer you can think of using free certificates from ACM.
Or you can consider using a NLB that the API gateway can talk to, using the NLB you can have your backend apis' in a VPC and have no public access and still have API GW talk to them.
Edit: For some reason I am not able to link correctly. Here are some links on ACM and NLB.
https://docs.aws.amazon.com/elasticloadbalancing/latest/network/introduction.html
https://docs.aws.amazon.com/acm/latest/userguide/acm-services.html

redpajama_set_name: RedPajamaStackExchange


updated on April 10, 2019 April 9, 2019 by juliaLeave a Comment on How Can I Tell If My Child Is Highly Sensitive?
Parents of Highly Sensitive Children (myself included) often struggle with getting their child to sleep. HSCs often have trouble falling asleep when overstimulated, and they tend to have more nightmares, too. This video tackles two big questions: What can I do about sleep issues? and How can I tell if my child is Highly Sensitive?
Are you looking for answers to your questions? I can help you with personalized advice through one on one coaching, regardless of where you live. Click below to schedule a free thirty minute consultation call.
What Can Writing Do for Your Parenting?