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You are here: Home / Sports Memorabilia News / Ruth's 1935 Braves Contract, 1948 Letter Coming to Auction
Ruth's 1935 Braves Contract, 1948 Letter Coming to Auction
The last contract Babe Ruth signed as an active player with the Boston Braves and a thank you letter to the New York Yankees after Babe Ruth Day in 1948 will hit the auction block later this month.
Goldin Auctions is offering the items in its upcoming live auction at the National Sports Collectors Convention in Atlantic City on August 4. The auction, which begins accepting bids online July 11, features 100 lots of memorabilia, each valued at $10,000 or above. Ten different lots in the live auction feature Ruth-related items. Additionally, a corresponding catalog auction running through August 13 includes additional Ruth memorabilia.
An aging Ruth joined the Braves after parting ways with the Yankees prior to the 1935 season.
The contract is housed in a custom leather case under a protective acetate page. The standard National League Uniform Player's Contract made out to "George Herman Ruth" includes his team as the "Boston National League Baseball Company" and the terms "$25,000 per year for a term of three years". Ruth only made it until June, announcing his retirement after struggling in the field and most of the time, at the plate as well. He did manage to belt three homers in a game during his final days as a National Leaguer, finishing with 714.
The second page of the contract is dated February 28, 1935, two days after the Yankees released him. It's signed by Ruth, Braves president Emil Fuchs and witnesses Samuel Silverman, F. Burton Whitman and James O'Leary. The signature has been rated Gem Mint 10 by PSA/DNA.
"It has been our honor to sell a pair of Ruth Yankee contracts recently for record prices and despite Ruth playing just 28 games for the Boston Braves, we expect this document to follow suit," said Ken Goldin, Founder of Goldin Auctions. "Combined with his farewell letter to the Yankees and one of the last autographed photos he ever signed, this is a trio of historic artifacts that truly put a punctuation mark on a remarkable life and career."
Ruth's letter to Yankees' President Dan Topping was written the day after Babe Ruth Day was held at Yankee Stadium in 1948, not long before Ruth's death from cancer.
The 7.25″ x 10″ typed letter on "Babe Ruth" personal stationery is dated June 14, 1948. Typed by a secretary and signed by Ruth, the letter reads, "My dear Dan: May I take this opportunity of thanking you and the New York Yankees organization for the watch which I received from you on Sunday. It was deeply appreciated. It was unfortunate that the weatherman played tricks on us but the lack of clear weather was made up for by the warmth of the ovation the Old Timers received. And I especially wish to add my words of thank you for the privilege of participating in this celebration. With kind personal regards, believe me, I am, Sincerely, Babe Ruth".
The signature is in blue fountain pen, and has been rated 9 out of 10 and comes with a full LOA from PSA/DNA.
The auction also includes a PSA/DNA 10 rated 11″ x 14″ Ruth signed and inscribed photo from a scrap-book that was filled with pictures, newspaper columns, and letters of well wishes and press materials. Written in black fountain pen, the autograph reads "With best wishes From Babe Ruth." Auction officials say it could be the largest known single-signed Ruth signed photo.
To register for the auction or to receive a free catalog, visit Goldin Auctions' website.
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Filed Under: National Sports Collectors Convention, Sports Memorabilia News Tagged With: 2016 National Sports Collectors Convention, Babe Ruth autographs, Babe Ruth contract, Babe Ruth memorabilia, Goldin Auctions


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Q: Execute a new entirely seperate process packed inside of an executable without a file written to disk for seperate process I'm aware the title sounds a little bit overwhelming, however the key concept is simple.
I'm not too picky on language, it could be any .NET language however I prefer C++.
I want to store a compiled executable inside of another executable, which at runtime will run the other executable from memory, not from disk.
Is this even possible, and if so could someone please provide an example?
I am not referring to a DLL. I'm talking about an independent executable.

A: You can create a stub EXE in C# that loads an assembly from bytes using IPC from your process, then uses reflection to find and run a Main() method
However, that EXE will still need to run from disk.

A: You need something on disk to run there's no way around that. You can make your own executable the shim that you use to load the other exe. Your host program would look something like this:
class Program
{
    public static void Main(string[] args)
    {
        if (args.Length > 0 && args[0] == "launch")
        {
            AppDomain.CurrentDomain.AssemblyResolve += CurrentDomain_AssemblyResolve;
            AppDomain.CurrentDomain.ExecuteAssemblyByName("TestConsoleApp", "some", "args", DateTime.Now.ToString());
        }
        else
        {
            RunNormally();
        }
    }

    private static void RunNormally()
    {
        string fileName = Process.GetCurrentProcess().MainModule.FileName;
        fileName = fileName.Replace(".vshost", ""); // hack -- if launched in the debugger must remove this.
        Process.Start(fileName, "launch");

        // do other stuff
    }

    private static Assembly CurrentDomain_AssemblyResolve(object sender, ResolveEventArgs args)
    {
        var asmName = new AssemblyName(args.Name);
        var resourceName = Assembly.GetExecutingAssembly().GetManifestResourceNames().FirstOrDefault(r => r.Contains(asmName.Name));
        if (resourceName != null)
        {
            using (var memoryStream = new MemoryStream())
            {
                Assembly.GetExecutingAssembly().GetManifestResourceStream(resourceName).CopyTo(memoryStream);
                return Assembly.Load(memoryStream.GetBuffer());
            }
        }

        return null;
    }
}

This assumes you have an assembly "TestConsoleApp" as an 'Embedded Resource' in your hosting  executable.

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Worcester, MA --- WPI Track and Field athletes Mike Thyden (Sutton, MA) and Caroline Eigenbrodt (Chatham, NY) each competed at the Holy Cross multi events meet on Wednesday and Thursday. The competition, comprised of Division I and Division III entries, is a rare chance for multi-event athletes to qualify for championship meets.
Thyden assured himself a spot in the Division III New England Championship meet in the decathlon as he posted 5076 points for 11th place. The junior's highlights included a 53.33 in the 400-meter dash and a 12.01 in the 100-meter dash.
In the heptathlon, Eigenbrodt moved up three spots from day one to finish in 21st spot with 1905 points and capped off the two-day event with her best performance, a 2:41.73 in the 800-meter run.
The Men's and Women's Track and Field squads hit the road on Saturday when they venture to Springfield for the final regular season meet.


Meet Dalton. He happily lives in the Bachelor Tower where women are allowed to visit but never stay for more than one night. It's a dream come true until his entire life is turned upside down by one irresistible woman.


Please note that we won`t take any responsibility for the hiking times mentioned!
Download the map » Ascent from Elmau-Hotel via "Wettersteinalm" ("King`s Trail").
Starting from the Hikers´car park (Wanderparkplatz) past Elmau-Hotel, you follow the "King`s Trail"-signs (Königsweg) via "Wettersteinalm" to "Schachen".
The trail is about 7 miles long and has a difference in altitude of about 2550 feet. This is the most well known and easiest ascent, very much appreciated by mountain bikers as well.
Download the map » Ascent from Elmau Hotel via "Wettersteinalm" and"Schachentor" ("Schachen-Gate").
The trail starts at the Hikers´Car park (Wanderparkplatz) near Elmau-Hotel and follow the so called "King´s Trail" up to "Wettersteinalm". From there, the path climbs steadily along impressive walls of rock up to the "Schachen-Gate" (mountain ridge).
Having passed this highest point, the path somewhat descends, and after one last ascent, leads you to "Schachenhäuser", providing accommodation and meals. Nearby, you find the King´s House, offering guided tours. This trail is somewhat shorter but more strenuous than the one described above.


This is the second post in our series to celebrate Thanksgiving. We now call this our "Gratitudes Day" or "Grati-Tuesday" post. (We're still debating which name is best... You can read our first installment here).
In general in our work life, I find that too seldom do we take the time to express our thanks to those who make a difference. So Heinz and I wish to recognize our employees for the difference they make for our clients and their fellow teammates, each and every day.
- Meagan, our Director of Client Solutions, who started with us 8 years ago, and climbed her way from Client Care Specialist to Team Leader, Project Manager, Director of Project Operations... As she's preparing to take over the world, we're happy she's on OUR team!
- Pamela, our Business Development Specialist, who is also known to her friends and teammates as as Miss Sunshine. Aside from generating leads, she is also our Law of Attraction expert, always quick to remind us that our words can attract or detract -- so why not attract positivity?
- Tanya and Stacey, our Team Leads Extraordinaires, who have risen to the occasion in taking over the the project management reins. They still work those phone lines and communicate with clients over email, and take care of our scheduling, staff coaching and client reporting. They have been maximizing their respective strengths and complementing one another to make projects tick, on time and to our clients' expectations.
- Kiwi, our Quality Assurance Coordinator, who works remotely in Oshawa and is an integral part of our team as if she was right there with us, every day. She also has taken on more responsibilities this past year, continuing to keep us error-free and helping us get client projects organized and onboarded.
- Gwynydd, our Social Media Coordinator and Business Development Specialist, who is delightfully analytical and thorough with anything she takes on. A great writer and engaging tweeter, she keeps us straight by asking the right questions.
- Frank, our part-time IT Guru, who swoops in a couple of times per week to keep our network clocking, and our systems computing the way they should.
- Amy, our Client Care Specialist and Quality Assurance back-up, who sweetly but stealthily can convince any hard-core business executive they really ought to help us out and take that survey.
- Jennifer, our Client Care Specialist, who is a dedicated collaborator, always graciously recognizing her teammates and reliably making human-to-human connections.
- And Candace, our newest team addition and Client Care Specialist, who unknowingly was an inspiration for this whole gratitude idea to begin with.
We truly appreciate your dedication and look forward to earning your trust and loyalty.


Direct physical damage to buildings and infrastructure.
Indirect physical damage: e.g. Fire.
Economic and social losses: e.g. Casualties.
Indirect economic losses: e.g. Business Disruption.
To assess damage, the group is using information provided by Working Group 1: Shakemaps and secondary hazard maps. The Shakemaps will be input into HAZUS, a multi-hazard loss estimation methodology developed by FEMA, to estimate the region's earthquake losses. Finally, the numerical results will be reviewed by a panel of experts to generate the final assessment of damage in the region. This information will feed Working Group 3 to perform social and economic analyses.
This group meets bimonthly, the 4th Friday of every month. If you would like to get involved, please contact sdtij-scenario@eeri.org.


With an extensive experience in the market, our feed division offers high quality additives and raw materials adapted to the last tendencies in nutrition and animal health. With our suppliers collaboration we offer an excellent technical assessment with which we can support you and search for the best solution adapted to your needs. Our main markets are aviculture (poultry and layers), porcine and petfood industries.
With our suppliers collaboration we offer an excellent technical assessment with which we can support you and search for the best solution adapted to your needs.


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Home » india » Pramod Boro, Hagrama Mohilary confident of BTC majority test
Pramod Boro, Hagrama Mohilary confident of BTC majority test
12/23/2020 Comments Off on Pramod Boro, Hagrama Mohilary confident of BTC majority test
The Gauhati High Court ordered a composite floor test by December 26
Pramod Boro, the newly-elected Chief Executive Member of Assam's autonomous Bodoland Territorial Council (BTC) has said his three-party alliance would prove majority in the floor test for the council.
His predecessor Hagrama Mohilary, president of the Bodoland People's Front (BPF), too, exuded confidence about "beating the odds" while offering the two regional allies of the Bharatiya Janata Party an alternative combination for ruling the BTC.
The BPF, which won 17 of the 40 BTC seats to emerge as the single largest party, had challenged the constitutional validity of the appointment of Mr. Boro and four others as heads of the council on December 15. The BPF cited rules to argue that the Governor, who is the constitutional head of the BTC, should have invited it first to prove majority in the council.
Hearing the BPF's petition on December 22, the Gauhati High Court sought a floor test on or before December 26.
"We will be happy to showcase the thumping people's verdict to govern BTR (Bodoland Territorial Region comprising four districts under BTC) for the next five years on 24th December 2020 at 10 am," Mr. Boro wrote in his social media account.
He is the president of the United People's Party Liberal (UPP), which forged a post-BTC election alliance with the Bharatiya Janata Party (BJP) and the Gana Suraksha Party (GSP). The lone Congress member of the council too switched over to the saffron camp and joined the alliance.
The alliance has 23 seats, Mr. Boro having won two of them.
"We are coming back to power. It will be clear on the day of floor test," Mr. Mohilary said, insisting there was nothing personal against anyone in the BPF going to the court.
He also offered the UPPL and GSP an alliance with the BPF.
"I firmly believe the regional parties should form the administration in the BTC. I am open for talks, and it does not matter who becomes the Chief Executive Member," Mr. Mohilary said.
The BPF, otherwise a constituent of Assam's BJP-led coalition government, ruled the BTC for 17 years since its creation in 2003 as a political solution to the Bodoland Statehood movement. The BPF's reign ended with the dissolution of the council on April 27.
BBodoland Territorial Council
Check out these calendars featuring rescue animals for the year 2021
Kajal Aggarwal completes her first schedule for Acharya

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Spread of the Intelligent Dengue Virus
A small RNA strand able to make ten proteins has become the scourge of much of the world in the form of Dengue fever. This remarkable tiny virus is able to thwart the complex human immune reactions that fight viruses. Using some unique features, it is rapidly spreading through the world and infects millions of people per year—over 100 countries with 3.6 billion people at risk of very serious infection and death. Thankfully, most of the illnesses are mild, but a small percentage of the illness (unfortunately, still as very large number of people) is serious.
Dengue virus shows unique intelligence and behavior in entering cells with multiple techniques, evading immune responses and, very surprisingly, actively working to stop the effectiveness of vaccines by constantly altering protein shapes.
Other Intelligent Viruses
Previous posts have described the remarkable behavior of several viruses that have very few genes and proteins. They use constantly evolving very complex maneuvers to block the immune receptors, cellular signals and metabolic cascades that are used to fight virus infection.
Ebola virus has only 7 genes and proteins, but is able to build a very large complex vessel to travel between cells (see post). It uses many different attachment devices to enter each type of human cells. Ebola is able to fool cells into helping it enter. It is able to evade complex immune mechanisms with equally complex counter measures, while relying on this small number of proteins. Ebola is able to create a decoy to confuse the immune system and it commandeers complex protein rafts that are floating in the cell membrane to help it build the new viruses.
HIV was described in another post with only 9 genes and proteins. It travels with special proteins in its cover to evade immune reactions and enter cells. It attacks the most intelligent and complex T cells and immobilizes them with their few molecules. Inside the cell it evades immune reactions in very complex ways and then manipulates the nuclear pore and the genetic machinery.
Herpes has more genes—70—but has a very complex lifestyle (see post). It travels up and down neurons and in and out of skin cells. It changes its behavior in the neuron and becomes quiet where it can sit for many years. Then it self activates and travels again.
It is quite remarkable what these viruses can do with so few genes and proteins. It is quite fantastic that each protein can have multiple complex enzymatic funtions. It is not at all clear how they can do so much with so little. Now, Dengue virus is spreading and attacking with only 10 genes. It has been uniquely difficult to stop because of unusual reactions to antibodies.
Dengue is a single strand RNA virus that lives either in humans or in two specific mosquitoes, Aedes albopictus and aegypti, but is now the major virus spread through insects in the world. There are four sub types, all of which can cause severe illness. The current species developed in the past hundred years.
Dengue virus has many different ways to attach to various cells. It uses a variety of human molecules to enter cells, such as multiple glycosaminoglycans, lactins, mannose receptors, and special immune proteins (immune modulatory proteins TIM and TAM receptors.). Using this many different ways of entry makes study very complex and the most common method is not yet known or fully understood. It is quite remarkable that it can have all of these methods with so few genes and proteins.
Dengue is able to enter critical immune cells such as mast cells (which secrete factors to help open blood vessels for travel) macrophages (which are supposed to eat them) and monocytes and dendritic cells (which are supposed to bring virus particles to T cells to make antibodies and stimulate attack cells). Dengue, also, enters liver cells and endothelial cells (see post on intelligent endothelial cells). They hijack all of these and change their behavior to protect the virus.
When the virus envelope (a vesicle sac in the form on an endosome) attaches to the membrane of the cell, it hijacks the complex clathrin mechanism to fuse with the cell's membrane. This alters the sac properties through acidity, which induces the shape of the envelope (E) protein to change in order to aid the fusion of the two membranes.
When the virus-protein particle is released into the cell, the RNA strand almost immediately makes one long protein consisting of all ten proteins. This large molecule is then cut into three structural proteins (C, E and M proteins) and seven non structural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5) produced by the virus. The exact cutting process is not understood, but, it appears that it is somehow done by a human protease enzyme. This involves great cooperation of the human cell.
From the positive RNA strand (like a messenger RNA that can make proteins immediately) it makes a negative strand RNA and in turn from this negative strand manufactures many positive strands for the future viruses. This production occurs near cellular membranes, which creates an active working network.
New positive RNAs are surrounded by a version of the E protein and pre membrane M protein to create an immature virus particle. Later, the E protein again changes its shape to form the more permanent and stable mature virus that leaves the cell. These changes occur with alterations in the three separate sub domain regions of the E protein. The immature virus particle has E proteins that take on a shape with two of them attached to prM (pre membrane protein). This complex of two Es and one prM forms a lattice with spikes sticking out all over the surface of the developing virus structure.
In the Golgi, special human proteases (furin proteases) are involved in the maturation of this structure. The maturation occurs when the E protein structures are altered so that they lie flat instead of the immature spike forms sticking out of the sphere. The pre membrane M protein is eliminated in this process. The smooth final surface resembles icosahedral or herringbone patterns and will leave the cell in membrane sacs by hijacking the exocytosis mechanism.
The changing shape of E proteins on the surface are a major problem for destroying the Dengue virus with antibodies, both in the immune reactions and the trials of vaccines. The smooth arrangement consists of antiparallel molecules of two E proteins in a herringbone pattern (a fish bone pattern).
There is much that is not known about Dengue virus' complex behavior. Cutting of the prM protein is necessary for maturation of the virus to become infectious. But, many of these proteins are not cut exactly, which complicates antibody attack on the virus. These partially cut versions can, also, be infectious, but less so. As mentioned, partially effective antibodies start a process that actually increases the danger of the virus with strong secondary infections.
When Dengue enters humans, the higher temperature allows even more variations and more antibody uncertainty. Some of these variations include rotated E proteins that allow the inner membrane to be exposed. This changes the effects of antibodies in unpredictable ways. The E proteins are quite flexible and variable in shape, which adds even greater complexity to its function and eradication. These changes alter the effects of different shaped antibodies in ways that are not really understood.
Production of effective antibodies is a critical piece in conquering the viral illness. The three parts of the E protein make three different kinds of environments for the antibodies. Some of the E proteins will respond to some, but not to others.
Dengue virus is able to trick the body's factors that allow it to enter cells. It is taken in by endocytosis with its sac fused to the cell's membrane. This is a complex process that is aided by the virus E protein (envelop protein). The viroid particle then travels to the endoplasmic reticulum where the RNA is copied and the various proteins are made in ribosomes. The virus is able to interact with the complex membranes of the ER for these processes. Antibodies attach to virus structures of one or two of the E proteins in several of the positions of the subunits. When the RNA is copied, it makes small virus particles that are surrounded by ER membrane buds.
Cells have recognition receptors (TLRs) that notice and latch onto loose RNA particles. RNA, also, triggers special sensors that are used to detect abnormal genetic material in the cell—however, this pathway is not understood. One of these pathways uses a molecule sensor, which the Dengue virus protein NS2B/3 cuts and the NS5 destroys. This stops the immune fight against the virus.
Dengue Virus Structure
The virus is spherical approximately 50nm is size. Several years ago, it was noted that the shape is altered by temperatures outside and inside of the human host. Three proteins make the structure—C (capsid protein), pre-membrane and membrane protein (prM/M proteins) and the envelope protein (E protein). An envelope sac made of lipids surrounds the protein structure. The strand of positive RNA is 10 kilo-bases long and is capped.
Dengue is a positive sense virus meaning that it is equivalent to a messenger RNA, which can immediately make proteins with the host machinery. Negative sense RNA first must be copied into a messenger RNA, which makes the initial process more complex. But, to make more RNA strands for the final virus, a negative strand is necessary as the template of the positive strands.
E protein is made of three subunits in a row. It is critical for many steps in copying the RNA to make more viruses. E protein is involved in the attachment to cells and entry into the cell. It is critical for fusion of the virus envelope and the cell membrane. It, also, helps assembles the new virus.
The prM (pre membrane) protein helps the formation and maturation of the viral particle; its structure is seven antiparallel β-strands stabilized by three disulfide bonds
The virus shell is made of glycoproteins with 180 complexes in a pattern made of E and M proteins. First, it forms an immature structure out of E and prM (pre membrane protein), with 90 complexes in a herringbone pattern that makes spikes around the spherical shape. This immature version buds from a piece of the endoplasmic reticulum membrane and travels to the Golgi along the secretory pathway (see Complexity of Cellular Membrane post). In the Golgi, low pH changes the shape of the E protein that dissociates from the prM proteins making a flat pattern of just E proteins around the surface of the spherical final virus.
The pre membrane portion is cut from the M protein by the host furin protease enzyme. However, even the cut pr portion hangs on until the virus is released from the cell acting as a cap covering the fusion loop used for entry. The M protein sits under the E protein as part of the cover and membrane in the final product. It is remarkable the the pre membrane protein has so many completely different uses.
Non-Structural Proteins
NS3 protein is an enzyme that cuts at the serine amino acid. It is, at the same time, an enzyme that remodels RNA (helicase) and provides multiple other enzymatic functions in the RNA transcription process. It is a very clever protein and has a complex structure to provide all of these functions with six β-strands arranged into two β-barrels formed by residues 1–180 of the protein. The most important section of the protein that catalyzes all of these reactions is between the two β-barrels.
NS3's function, also, needs NS2B, which serves as a co factor. NS2B wraps around the catalytic section and is active in the various critical enzyme functions. There are three other sections from amino acid 180 to 618 that are active as well. These are made up of different combinations of six-stranded parallel β-sheets, 2 antiparallel β-strands and α-helices.
The NS5 protein has 900 peptide residues and functions as a methyltransferase on one end and a RNA-dependent RNA polymerase at the other. The methyltransferase active site includes a sandwich structure of sheets of α/β/β along with other sub units. It has special sections that are able to work with nucleotides.
Nonstructural proteins allow the inhibition of various mediators of the innate immune system response. These proteins act on two levels. First, they inhibit inferferon. NS4B sits in the ER and stops phosphorylation of the critical immune factor STAT 1 from the interferon cascade.
NS5 inactivates STAT2, another critical part of the interferon cascade of anti viral activity. The complex process NS5 is cut with NS4B by a virus protease NS2B3. This damages STAT2. After the cut, E gets in the act and a section of E, E3, targets STAT2
NS2B3 has a special protease complex with a core of the last 40 amino acids of NS2B and the first 180 amino acids of NS3. Cutting the NS2B3 precursor triggers this protease complex, which inhibits production of type I interferon by triggering genetic networks and stopping the interferon promoter.
Evasion of Innate Immunity
IFN from Trlkly
A major immune reaction to viruses is triggered by interferon type 1 (IFN). Several cellular receptors trigger this reaction for Dengue after sensing RNA in a place where it shouldn't be. The signaling cascade that occurs has many different molecules and triggers a large genetic network of hundreds of genes. These produce molecules that block the Dengue processes.
Somehow, Dengue, with its few proteins, is able to counteract these measures. Dengue is able to decrease type I IFN manufacture as a whole and stop particular signals that trigger important immune myeloid cells. Even more surprising is that the virus can alter specific ways that the immune cells present the antibodies (such as dendritic cells) so that the problems already mentioned with creating antibodies are increased. Dengue is able to specifically take advantage of the confusion relating to effects of antibodies.
The inhibition of the type I IFN is accomplished by a molecular structure consisting of two of their non-structural proteins NS2B and NS3. This creates a large enzyme that attacks specific proteins, one of which is the STING molecule that is critical in the cascade of interferon effects. It breaks down STING so that many other cascading molecules can't work. This breakdown only occurs in human STING, not mouse. Stopping the effect of the cascade has multiple effects that are positive for Dengue.
However another, entirely different mechanism occurs in this cascade by NS4B. It blocks another signaling molecule stopping phosphorylation. And yet another attack on the IFN cascade occurs by NS5.
Therefore, three entirely different mechanisms fight this critical antiviral pathway with three of the seven non structural proteins.
Immune reactions to Dengue are not totally understood. When there are a large amount of antibodies produced, they attach to the virus and neutralize them. However, if there is a lesser concentration, they can do the opposite and actually help the virus to enter cells by triggering a specific receptor. (FcγR). Antibodies are generated against specific proteins made by the virus and these then increase a secondary infection with a more severe disease. In research, adding antibodies increased disease in animals. This same effect can occur from mother's giving birth with more severe disease in the children.
There has been a great effort to develop a vaccine for this terrible virus, but Dengue presents unique challenges for this. Any vaccine of one of the sub types increases the danger of the others. The variable nature of the E proteins, also, adds to this danger. Current strategies in development are using four yellow fever vaccine viruses with four sub types of Dengue. Surprisingly it only helped people previously exposed. Another complex version had a 50% response. Another version is more promising with one study at 90%.
There are other possible treatments that attack mechanisms in the Dengue life cycle. But, limiting mosquitoes is probably most important currently.
Infection produces antibodies for one particular sub type. But, as soon as the other subtypes activate, the first antibody effect increases the illness and possible hemorrhagic shock. The virus copying increases and is able to overcome macrophages trying to eat them. This is especially difficult when mothers who are infected give birth and pass on their particular insufficient antibodies. This increases the chance of severe shock in the babies.
Dengue is able to alter innate immunity reactions by stopping specific receptors on white blood cells including mast cells. It increases IL-10 and alters the normal T cell reactions. It causes immune cells to secrete substances that alter the blood vessels and make them leaky. Another type of T cell attempts to continue to fight the infection.
How can a small strand of RNA produce proteins to accomplish so many different complex maneuvers? Where is the direction for all of this?
How do these proteins each perform many different complex actions? How do these proteins add new complex functions as the virus develops over time and fights the extremely elaborate innate immune system?
Dengue virus hijacks multiple different receptors for cell entry and it uses the host cell's complex clathrin mechanism. Commandeering the machinery to make its proteins involves another dimension. How does the virus arrange several critical steps using enzymes from the host. How does it know to use its proteins to cut parts of the IFN cascade?
The extremely successful and complex function of a strand of RNA has to raise questions of where the guidance originates. Is this mind interacting with the molecules?


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Kathmandu, Aug. 16: The House of Representatives, in its meeting today, approved separate proposals seeking passage of some bills and discussions on some others.
The lower house of the Federal Parliament unanimously passed the proposal seeking approval of the Public Security (Third Amendment) Bill, 2075.
Minister Home Affairs Ram Bahadur Thapa had presented a proposal to this effect in the meeting.
The House also approved another proposal tabled by the Home Minister seeking discussions on Public Security (Third Amendment) Bill 2075 along with the report of the State Affairs and Good Governance Committee.
The House meeting also unanimously approved the proposal presented by Minister for Culture, Tourism and Civil Aviation Rabindra Prasad Adhikari seeking discussions on the Convention Providing for the Integration of Laws on the Topic of International Air Transport.
Similarly, the lower house of parliament today approved unopposed the proposal seeking consideration on the Consumer Rights Protection Bill, 2075. Minister for Commerce and Supplies Matrika Prasad Yadav had presented the proposal.
Putting their views on the theoretical aspects of the bill in the discussions, lawmakers said that the government has not been able to arrest the large scale black marketers, the consumer court has been made weak, the court was run by administrators and not experts, and that there was no provision for affidavit in the court. They also complained about the growing problem of food adulteration and other anomalies in the market which were hampering the consumers' health and violating their rights.
Replying to questions raised in course of the discussions, Minister Yadav said the bill has been brought with the objective of promoting the consumers rights and use of quality goods.
Likewise, the House unanimously approved the proposal seeking consideration on Pension Fund Bill, 2075 which was presented by Finance Minister Dr. Yuba Raj Khatiwada.
Taking part in the discussions on the theoretical aspects of the bill, lawmakers suggested that pension should be increased only up to five years, making special provisions to alleviate the difficulties that arise with increasing age of pensioners and providing the old-age allowance and widow allowance along with the pension.
Finance Minister Khatiwada, responding to the questions raised by MPs during the discussions, said that pension is one among the many means of social security and it did not include all as it is given only to the government employees after they retire from their services.
Earlier, the House of Representatives had approved unopposed the proposal seeking consideration on the Safe Motherhood and Reproductive Health Rights Bills, 2075.
Deputy Prime Minister and Minister for Health and
Population, Upendra Yadav, had presented the proposal.
Putting their views on the theoretical aspects of the bill, MPs complained that a mechanism for the implementation of the reproductive rights was not put in place. They also suggested including provisions in the bill for assigning at least one doctor in places having a population of 1,000. The lawmakers said that it would be possible to implement the safe motherhood and reproductive rights only when education and health services are free.
They also said that foreign investment should not be allowed in the education and health sectors and that maternity leave should be given to women working in the agriculture sector and as domestic workers. The lawmakers also demanded providing nutritious food to the poor and vulnerable sections of society.
Responding to the questions raised by MPs during the discussions on the proposal, DPM Yadav said the bill has been presented keeping in mind the health of the mother and the child. He said the bill would help in reducing abortions and uncontrolled births. The Health Minister also expressed the belief that the bill would help reduce the maternal and child mortality rate.
He also shared on the occasion that a basic health centre and birthing centre would be set up at each ward of the local level.
The House of Representatives shall next meet at 1 pm on August 17.


text:
Q: How do we solve this Testing of Hypothesis problem?
To find critical region we can use Lemma-Pearson Lemma
$$\frac{L_1}{L_0} > k$$
$$\frac{ \prod_{i=1}^{n} \theta (1-x)^{\theta-1}}{ 1*(1-x)^{1-1}} > k,\space \space\space \theta >1$$
$$\prod_{i=1}^{n} \theta (1-x)^{\theta-1} > k,\space \space \space  \theta >1$$
$$(\theta)^n \prod_{i=1}^{n}(1-x)^{\theta-1} > k$$
$$\prod_{i=1}^{n}(1-x)^{\theta-1} >\frac{k}{\theta^n}$$
Taking log on both side
$$\log_e( \prod_{i=1}^{n}(1-x)^{\theta-1} )> \log_e(\frac{k}{\theta^n})$$
$$\sum_{i=1}^{n} \log_e ((1-x)^{\theta-1}) > \log_e(\frac{k}{\theta^n})$$
Is my approach correct if correct how do we proceed further in this question?

A: First observe that, given that $H_1$ is a composite hypothesis actually you have to use another method to find UMP test: as an example, monotone likelikood ratio or Karlin Rubin
After some calculations you find that the Statistic Test is
$$T=\sum_i\log(1-X_i)$$
To find the distribution of $T$, first observe that
$$Y=-\log(1-X)\sim \exp(\theta)$$
and thus $\sum_y Y\sim\text{Gamma}[n;\theta]$ that, under $H_0$ it is a $\text{Gamma}[n;1]$
Concluding:
$$-2T\sim\chi_{(2n)}^2$$
Concluding, the rejection region is
$$P(T>k|\theta=1)=\alpha$$
$$P(-2T<k^*|\theta=1)=\alpha$$
or equivalently
$$-\sum_i \log(1-X_i)^2<\chi_{(2n),1-\alpha}^2$$
This is result A


Martin & Sylvia's Audio Advent Calendar – Day 21: "The Angel"
In this Martin & Sylvia's Audio Advent Calendar story, "The Angel," Sylvia is feeling envious of her friend Sofia because she is going to play the angel in the Christmas play. Luckily the day's Advent card has a gentle message for her.
This story is all about gifts for other people. Not just material gifts but gifts of the heart, gifts of friendship and encouragement.
Make a gratitude list for yourself and two other people. Then send out the letters to everyone. Yes, to yourself, too!
Make a point of saying "thank you" with your whole being for an entire day.
Use these leaves to help you or child or the whole family realise all that they have to be thankful for. Then use the leaves to say three good things about the people in your house.


Triclosan is used to kill bacteria. It was previously a common ingredient in liquid soaps labeled as "antibacterial" or "antimicrobial," but this use was banned by the US Food and Drug Administration (FDA) as of September 2017. This is because there are no extra health benefits of using soap with triclosan compared to ordinary soap, and the wide use of antibacterials poses health concerns. Triclosan is still used in other personal care products, such as some toothpaste and cosmetics, although certain companies are phasing it out. It is also added to many household products and building materials.
Housewares, such as cutting boards, serving utensils, storage containers, humidifiers, and vacuum cleaners.
Home furnishings, such as mattress and pillow covers, shower curtains, and rugs.
Children's toys and sporting goods, such as exercise, playground, camping, and boating equipment.
Some personal care products, including some toothpaste and cosmetics like blush and eyeshadow; and combs, brushes, and razors.
Building materials, such as some countertops, caulking, concrete, tiles, flooring, and bathroom fixtures.
May make it harder for antibiotics to fight infections. This is because overuse of triclosan and other antibacterials may cause changes in bacteria that make them harder to kill.
Avoid personal care products that list triclosan on the label, unless you have a medical reason for using them. For example, toothpaste with triclosan may help prevent gingivitis (inflammation of the gums).
For housewares and other consumer products, look for untreated materials, which could include wood, glass, stainless steel, and natural fabrics like wool. If you can't tell whether a product has been treated with triclosan or other antibacterials, contact the manufacturer.


BISCOITO COOKIES JASMINE DIET AMEIXA PRETA E COCO 150 G.
BISCOITO COOKIES JASMINE DIET CASTANHA DE CAJU 150 G.
BISCOITO COOKIES JASMINE DIET CAPUCCINO E AVELÃ 150 G.
CHOCOLATE FLORMEL 52 % CACAU COM AVELÃ 20 G; SEM ADIÇÃO DE AÇUCARES; ZERO LACTOSE; SEM GLÚTEN.
CHOCOLATE FLORMEL 52 % CACAU COM AMÊNDOAS 20 G; SEM ADIÇÃO DE AÇUCARES; ZERO LACTOSE; SEM GLÚTEN.
CHOCOLATE FLORMEL 52 % CACAU COM CRANBERRY 20 G; SEM ADIÇÃO DE AÇUCARES; ZERO LACTOSE; SEM GLÚTEN.
CHOCOLATE FLORMEL 56 % CACAU; COM 5 G DE PROTEÍNAS; SEM ADIÇÃO DE AÇUCARES; SEM GLÚTEN.
CHOCOLATE GOLD BRANCO DIET 25 G; ADOÇADO COM SUCRALOSE.
CHOCOLATE GOLD DIET 72 % CACAU 25 G; ADOÇADO COM SUCRALOSE.
CHOCOLATE GOLD AO LEITE COM CASTANHA DE CAJU DIET 25 G; ADOÇADO COM SUCRALOSE.


text:
Q: Error in custom java class imported into Oracle EBS r12 I have a custom java class imported into Oracle forms in Oracle EBS R12, but when I am going to run the java functionality in the application it gives me the following error:

exception:java.lang. exception: java.lang.NoClassDefFoundError: getsipbyname_proxy/proxy/GET_SIP_by_NamePortClient

Could you help me to know why am I getting this error?


text:
Q: How to rename many dataframe columns efficently to a specific format in R Let's say I've a dataframe which each column represents a group age and I need to rename them as "age_index"
e.g:
x <- data.frame(x = 20:56, y = 36:72, z =10:46 , stringsAsFactors = FALSE)
index <- 0:2
age_base <- rep(c("age_"), times = 3)
age_name <- paste(age_base, index, sep="")
names(x) <- age_name

My question is if I've other variables (many more) such as weight and height and need to change them to that format "var_index" how can I do this without having to repeat paste(rep(c("var_index"), times = n), index, sep = "") for each one of them.

A: If all of them have the same replications, then just concatenate the prefix names as a vector, and use each instead of times
paste0(rep(c("age_", "weight_", "height_"), each = 3), index)
#[1] "age_0"    "age_1"    "age_2"
#[4] "weight_0" "weight_1" "weight_2"
#[7] "height_0" "height_1" "height_2"

Note that the index vector is of length 3 and it gets recycled to the length of the replicated.

If instead, we have different number of replications, use times (by default it will be used)
v1 <- c(2, 4, 3)
paste0(rep(c("age_", "weight_", "height"), v1),
       sequence(v1) - 1)
#[1] "age_0"    "age_1"
#[3] "weight_0" "weight_1" "weight_2" "weight_3"
#[7] "height0"  "height1"  "height2"


Request Robin's Home Free Value Analysis. How you can get the most money for your home in this "buyers" market. See why Robin Gordon has been leading the mainline in real estate sales for 20 years!
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The best canister vacuum on the market right now. Edges out the competitors in terms of overall performance.
36 foot operating range makes it incredibly efficient in covering hard to reach areas. Lightweight yet extremely powerful in terms of suction.
A good choice if you want a bagless option backed by a superior warranty that helps make up for the high price tag.
Adjustable height and power makes it ideal for cleaning different surfaces. Has telescopic wand and 8 ft. hose for optimal cleaning. Comes with a 5-year warranty.
It's expensive, but for the exceptional performance, you might not mind the price.
If a lightweight design is important to you, this is a solid choice.
Stands out for being extremely lightweight yet powerful. Simple to use in tight spaces and to carry up and down stairs.
Requires replacement bags and filters and is somewhat noisy.
At a fraction of the price of other models, it is the hands-down best choice for the budget-conscious consumer.
A trusted brand in the industry that offers versatile cleaning. Has all the features of similar models at a bargain price.
Requires bags. Suction is slightly more powerful on hard surface floors.
Despite a few issues, the new Mighty Mite outpaces previous generation models thanks to features and design.
With a combination of a lightweight build, reliable suction, and easy-to-clean dust bag that helps prevent messes, it's a solid deal for a mid-range price.
Hose has a flimsy feel. Loud. A few reports of faulty models that malfunction after a few months of use.
Getting your floors clean quickly and easily is a priority, but it's not a straightforward choice when choosing your tool — with upright, canister and stick vacuums to choose from.
Hands down, canisters win out over the competition when it comes to hardwood floors and other bare surfaces. However, a good, powerful canister model will also work well on carpets and rugs. They also have better maneuverability and clean up the competition when it comes to blinds, curtains and overhead fixtures, making them a useful addition to your cleaning arsenal.
We've rounded up the best of them, with must-have features like telescopic wands, carpet brushes, a variety of tools and adjustable suction. The prices range from a sizeable investment for a quality model with lots of bells and whistles to small budget options at very affordable price points. Whichever you choose, look for lightweight models, especially useful for ease of use on stairs, and a good manufacturers' warranty.
Why choose a canister vacuum cleaner?
When it comes to basic floor care, there are three common types of vacuum cleaners: upright vacuums, stick vacuums, and canister vacuums. Each type offers its own strengths and weaknesses.
Upright vacuums are usually the best choice if you have a home that's mostly carpeted. A good upright vacuum cleaner has considerable suction power and, generally speaking, a wider cleaning path than a canister vacuum cleaner. On the downside, upright vacuums are heavy, can be difficult to maneuver, and are extremely tricky to use on the stairs.
Stick vacuums are best reserved for quick cleanups. Unless you live in a very small home, a stick vacuum isn't going to replace your regular vacuum cleaner. But a stick vacuum is great for vacuuming up crumbs or spills, getting your place presentable before company arrives, and sucking up pet hair. Cons include a lack of power, a small dirt collector, and a so-so performance on carpeting.
Canister vacuums are excellent for hard floors, and depending on the model, they do a fair-to-good job on carpeting as well. Canister vacs are also much easier to maneuver than uprights. They reach further underneath furniture, and because of their design, they feel much lighter during use.
If your home has a staircase, you'll appreciate the long hose and separate head of a canister vacuum cleaner. Plus, you can use a canister vac on drapes, upholstery, and even the interior of your car.
There are a few drawbacks to canister vacuum cleaners. Many cannot compete with an upright vac when it comes to carpeting, particularly if the carpet has a high pile. The smaller head of a canister vacuum takes longer to cover a large expanse of floor, and it's harder to store a canister vacuum than it is an upright.
Still, if your home has stairs, lots of hard flooring, tight corners, and/or furniture raised up on legs (as is common with midcentury modern design), a canister vacuum could well be your best choice.
If you're planning on a full housecleaning, save the for vacuuming last. That way, you'll gather up all the dust and crumbs dislodged by your other cleaning activities.
Check your vacuum cleaner's roller brush periodically, especially if it stops working effectively. It's common for hair and string to tangle in the brush's bristles.
When vacuuming a carpet, make a few passes over each area of flooring. Most vacuums require at least two or three passes to adequately lift out embedded dirt and hair.
Bagged vacuum cleaners hold collected dirt and dust in a bag that is tossed in the garbage when full. Many bags have HEPA-filtering capabilities that greatly cut down on allergens and prevent dust from collecting inside the vacuum or blowing back into the room.
Pros: Bagged vacuums are the best choice if allergies are a major problem in your home. You won't need to replace or clean the filter as frequently, and you won't be exposed to allergens or dust when replacing the bag.
Cons: You'll need to buy bags, and most vacuums start losing suction power as the bag becomes full.
Bagless vacuums have a plastic chamber that collects dust and litter. You empty the chamber when it's full.
Frequently, this is a messy process that exposes you to all the allergens and grit inside the chamber.
Pros: There are no bags to buy, thus reducing your ongoing expense. And bagless vacuums are more environmentally friendly, since you aren't tossing a paper bag.
Cons: Along with the potential for a dusty mess when emptying the chamber, you'll also have to clean the vacuum filter more frequently, as the dust tends to escape and gather in the filter.
Switching directions while you vacuum will dislodge dirt, hair, and other grime from your carpets.
Canister vacuum cleaners come with a wide range of possible features, and some of those features might suit your needs better than others. Here's a list of the most common features to consider.
Unless you live in a tiny space, vacuuming your entire home generally means unplugging and replugging your vacuum cleaner cord at least once or twice as you work. A long power cord – 20 feet or longer is best – cuts down on how often you'll need to do this.
This handy feature automatically rewinds the power cord at the push of a button or with a slight tug.
While many canister vacuums have a hose that is five or six feet long, a longer hose makes it easier to reach behind or underneath furniture.
Every vacuum cleaner has at least one filter, but some have more than one. And some have HEPA filters to catch even the tiniest allergens and dust particles. In the case of bagged vacuums, the bag itself serves as a filter.
Bagless vacuums have a plastic container for collecting dirt. If this container is very small, you'll have to stop and empty it frequently.
This is usually a lever or knob that lets you set the roller brush height for different piles of carpet.
The wider the cleaning head of your canister vac, the less passes you'll have to make to clean the entire floor.
Clean or change your vacuum's filter on a regular basis. Clogged filters prevent the vacuum from suctioning at full power and scatter dust and allergens back into your room.
While you won't be lifting or pushing a canister vacuum cleaner in the same way you would an upright vac, it's still easier to work with a reasonably light vacuum cleaner.
Some canister vacuums let you adjust the power level so you can use lower suction while working on delicate surfaces and higher suction on carpets or big messes.
The roller brush – also called a beater brush – loosens and lifts grime and hair out of carpeting, but it could potentially scratch wooden or other hard-surface floors. Some canister vacuums have a switch to turn the roller brush off while working on wooden floors.
When the roller head is powered by electricity instead of air, you'll get much more powerful and effective suction on carpet and rugs.
If you have pets, you probably deal with shed hair on a regular basis. Canister vacuums marketed as "for pets" generally come with a powered pet head, which is basically a miniature vacuum head that excels at picking up hair from carpets, upholstery, and drapes.
Resist the urge to vacuum up small metal items like paper clips or coins. It's also smart to avoid picking up leaves shed from potted plants, balls of paper, and other large items with a vacuum cleaner. Attempting to suction up these items would likely clog the hose or damage the motor fan.
More common on upright vacuums than canisters, a headlight is very convenient when vacuuming underneath furniture or a bed.
Vacuum cleaners are noisy; there's no getting around it. But some models and brands are a little quieter than others.
Your canister vacuum will probably include a set of accessories. Typically, a hose extender, upholstery brush, and crevice tool are in this set. Higher-end vacuums may include other useful accessories, as well.
As a general rule, canister vacuums are more expensive than uprights, although you'll certainly find many bargain vacuum cleaners priced under $100. For a superior canister vacuum with many desirable bells and whistles, however, be prepared to spend $200 or more.
For a thorough clean, make the most of your vacuum cleaner attachments. These handy tools can help you reach underneath furniture, behind the toilet, and along the baseboards.
Q. How often should I use my canister vacuum cleaner?
A. For many homes, a weekly session with the canister vacuum usually suffices. If you have pets, kids, lots of foot traffic, or live in a dusty area, however, you'll probably need to vacuum more often.
Q. How often should I replace my canister vacuum bag?
A. It's recommended that you replace your canister vacuum bag when it's approximately two-thirds full. Beyond that point, your vacuum will start losing suction power.


text:
Q: ICP 3.1.0 Vagrant support *I used * [1]: https://github.com/IBM/deploy-ibm-cloud-private/blob/master/docs/deploy-vagrant.md
to install ICP 2.1.0.3 on my mac.
Does it support also ICP 3.1.0?

A: As of right now, I believe this tool cannot be used to install ICP 3.1.0 because the relevant icp-inception image has not been added to Docker Hub. When that image is available, the tool might work if you change the version parameter on line 22 in the Vagrantfile.
Even with the correct image, there may be other configuration steps that need to be taken such as changing the k8s_version or the memory requirements, since these have changed in 3.1.0.
EDIT: The image is now available on Docker Hub, but I have not tested configuring the vagrantfile to install 3.1.0 yet.

A: I used it successfully to install ICP 3.1 on my Linux PC. I just had to set
version = "3.1.0"

in the Vagrantfile.


HARMONIK WELCOMES TI PAPI PICTURES & REHEARSAL VIDEO + SCOOPS ON ZENGLEN. J PERRY. KALIKO ON FORT LAUDERDALE FEST RUMOR. DANO ON WHY HE REHEARSED WITH BELJAZ!
HARMONIK WELCOMES TI PAPI PICTURES & REHEARSAL VIDEO + SCOOPS ON ZENGLEN. J PERRY. KALIKO ON FORT LAUDERDALE FEST RUMOR. DANO ON WHY HE REHEARSED WITH BELJAZ...after quitting the band!
*HARMONIK 2.0 & TI PAPI: AFTER WORK...IT'S TIME TO STRIKE A POSE...SEE PICTURES!
*HARMONIK WELCOMES TI PAPI PICTURES AT REHEARSAL!
*KALIKO ON IF HE WILL BE WORKING WITH FORT LAUDERDALE FESTIVAL!
*WHY DANO WENT TO REHEARSE WITH BELJAZ.....AFTER HE QUIT!


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text:
Theme (1)
Arctic issues
Maritime spatial planning
Nordregio news (2011-2017)
Research articles / EJSD
Remove all filtering
The owl has landed
The Icefjord Centre is a complicated building in an extreme climate. Pay a visit to the Icefjord Centre and its surroundings in the article "The owl has landed" by Kjell Nilsson and Leneisja Jungsberg, and learn more about the magnificent building in interaction with the spectacular, but at the same time vulnerable, nature that surrounds it. Nowhere in the world is climate change as significant as in Greenland. The municipality of Ilulissat has therefore inaugurated a new visitor center where you can study and experience climate change and its effects at close hand. At the same time, the building, designed by the Danish architect Dorthe Mandrup, is itself an outstanding example of the interplay between world-class architecture and a unique and magnificent natural landscape.
No longer solid: how thawing permafrost affects people's lives in the Arctic
Rapid shifts in the environment caused by climate change impact people's live in the Arctic. The changes challenge food availability, cause safety concerns, and in some cases deteriorate people's health. Arctic air temperatures are rising up to four times as fast as the global average, and this causes dramatic changes to all components of the cryosphere, including permafrost. By 2050 permafrost will degrade and ultimately disappear in many areas of the Arctic and this will impact the lives of 3.3 million inhabitants. This storymap tells about local people and how they experience permafrost thaw. What challenges and impacts related to permafrost thaw do they recognize? How do local inhabitants deal with permafrost thaw and how does it affect their possibility to support themselves? The story presents the situation in three permafrost communities: Aklavik (Northwest Territories, Canada), Longyearbyen (Svalbard, Norway), and Qeqertarsuaq (Qeqertalik Municipality, Greenland).
Each issue of the Nordregio Magazine provides perspectives on a specific theme related to regional development and planning in the Nordic countries. With Nordregio Magazine you are kept up to date with the interesting research results produced by Nordregio in a European and global perspective.
Nordregio Strategy 2021-2024
The Nordregio Strategy 2021-2024 outlines our main mission and core research focus areas, which have been carefully aligned to address the key objectives and needs of policymakers and practitioners outlined within Nordic cooperation steering documents. In recent years, there has been a convergence of several global megatrends which are having a major impact on all aspects of the Nordic economy, society and environment. Climate change, migration, rapid demographic developments, digitalization and automation, increasing urban-rural divides, and growing socio-economic inequalities are some of the main threats facing the Nordic Region. Nordregio is focused on identifying practical Nordic policy solutions to help overcome these challenges and promote socio-economic growth and environmental sustainability across the Nordic Region. The Nordregio Strategy 2021-2024 has been written as a collaborative effort by our staff members in close cooperation with Nordregio's Board of Directors, which represents the Nordic countries, Faroe Islands, Greenland and Åland. The overarching goals that guide Nordregio's research are outlined in the Nordic Council of Ministers' Action Plan for Vision 2030, which is approved by the Ministers for Nordic Co-operation. The Action Plan defines the work to achieve the objectives of the Vision through a series of initiatives linked to the Vision's three strategic priorities: a green Nordic Region, a competitive Nordic Region, and a socially sustainable Nordic Region. During the 2021-2024 period, Nordregio is committed to delivering high quality scientific, evidence-based research designed to provide policymakers and practitioners with sustainable policies to help overcome the main challenges faced by Nordic regions and municipalities. Our research will contribute substantially towards Nordic cooperation and synergies, while also showcasing Nordic policies, experience and competences internationally. The Board approved the Nordregio Strategy on the 15th of April 2021.
The Nordic Cooperation Programme for Regional Development and Planning 2017-2020
With this document, Nordregio provides a final status of the professional work for the activities across and within the Thematic Groups after four years and three months of the Nordic Cooperation Programme for Regional Development and Planning (NCP-RDP). In this final report, one will find an overview of the projects carried out by each TG, including a brief abstract of achieved results. Links to further details are provided for each of the projects.
Planning for sustainable tourism in the Nordic rural regions – Cruise tourism, the right to roam and other examples of identified challenges in a place-specific context
In the newly published Nordregio report 'Planning for sustainable tourism in the Nordic region', over 100 tourism development plans (TDPs) from rural areas of the Nordic countries were collected, coded and analysed. And what was discovered is that among the shared challenges there are: management and coordination of tourism and tourism planning, securing local benefits from tourism, seasonality and extending the tourism season, increasing profitability and investment, environmental concerns, providing the necessary infrastructure and securing competence development. This report is a continuation for the previous report providing examples, like cruise tourism and right to roam, from the Nordics. This report is a part of the 'Rural tourism in the Nordic region' project, which is conducted by Nordregio under the Nordic Thematic Group for Sustainable Rural Development. For further information and detailed results of the analyses of the entire TDPs gathered for this research on sustainable tourism planning in the Nordic rural regions, we refer to the main report of the Rural tourism project, 'Planning for sustainable tourism in the Nordic region'.
Optimising the impact of Nordic climate policies
The challenge of reducing greenhouse gas emissions to halt climate change is global. It doesn't matter where emissions reductions take place, what matters the most is to reduce the overall global emissions as much as possible at the least possible cost. The Nordic countries' climate policies are relatively ambitious in an international perspective, and the countries have progressively raised their climate targets in recent years. However, when designing national climate policies, it is important to assess not only their effects on territorial emissions but also the degree to which they will affect emissions in other countries. This policy brief provides recommendations on how the Nordic countriescan optimise the overall impact of their climate policies. The recommendations are based on the analyses and main conclusions from Climate Policies in the Nordics – Nordic Economic Policy Review 2019. The report evaluates the cost-effectiveness and global impact of Nordic climate policy in the context of the Paris Agreement and the available mechanisms for international emissions trading.
Local smart specialisation: An approach to increasing preparedness in rural communities with resource-based industries in the Northern Periphery
A common challenge for Northern communities is how to retain a local benefit from resource-based industries. This study assesses the process of developing a local smart specialisation strategy in two municipalities, Storumanand Sodankylä, both located in the Northern Periphery. The assessment framework applied is based on the concept of 'strategic dimensions'(Healey, 2009), along with a qualitative set of process and outcome criteria(Innes and Booher, 1999). Our assessment of the strategic process indicates that all dimensions required for strategic planning were represented within it, but that they were mostly responsive rather than transformative in character. When comparing results from process criteria and outcome criteria, the process criteria score significantly higher. The strategic process engaged social networks and involved local stakeholders in discussion and joint prioritisation. According to the participating stakeholders, the local smart specialisation strategies in Storuman and Sodankylä enhanced local preparedness. However, a significant limitation was a lack of long-term human and financial resources to address challenges in relation both to resource-based industries and local, territorial development. This article is published by the European Journal of Spatial Development, which in turn is published by Nordregio and Delft University of Technology, Faculty of Architecture and the Built Environment.
Planning for sustainable tourism in the Nordic region
Pan-Nordic analysis of Regional Tourism Strategies for rural areas This project looks at the challenges facing the development of a more sustainable rural tourism in the Nordic regions. Our key interest is understanding the degree to which regional tourism strategies are used by the tourism actors, policy makers and local communities as tools to balance positive economic and social development in rural areas with the environmental or social burden of the tourism. What are the main concerns and interests in the different tourism planning documents? What visions for tourism development do they express, and what role do sustainability concerns play in the plans envisaged? Although this study was designed in 2018, prior to the current Covid-19 crisis and its wide-ranging impact on tourism, it contains results which are relevant to the changes in tourism planning taking place across all parts of the Nordic region in the wake of the pandemic.
Overcoming barriers to social inclusion in Nordic cities through policy and planning
This report examines how Nordic governments and municipalities seek to overcome barriers to social inclusion and to counteract inequality and segregation through policy and urban planning. Overcoming barriers to social inclusion is understood as the desire to improve the terms on which different individuals and groups take part in society through urban policy and planning while counteracting the negative effects of inequality. Examples of policy and planning initiatives to create more inclusive cities and communities can be found in all the Nordic countries. However, inclusion is a multifaceted issue and the specific challenges, and approaches to dealing with these challenges, vary among the countries and cities. To capture this diversity, this report examines five different thematic and geographical cases detailing strategies for inclusion from different perspectives in varying contextual settings. This report is the result of work done for the thematic group Sustainable Cities and Urban Development. The group focuses on: 1) social sustainability and gender equality; 2) spatial planning; 3) urban qualities in small and medium-sized cities, and the urban-rural relationship; and 4) the growth and development of Arctic cities. Within these broad themes the group decides what activities to conduct, and the researchers involved are responsible for the results.
Sámi nuoraid perspektiivvat, skuvlejupmi ja bargomárkanat
Dát dutkamuš viggá fállat oppalaš gova ja dieđuid sámi oahppoinstitušuvnnain ja sámenuoraid perspektiivvain, maid sáhttet ávkkástallat guvllolaš ovddidanfidnuin ja politihka hábmemis. Dutkamuš buktáge čoahkkái fuomášumiid sámi oahppoinstitušuvnnaid ja bargomárkana gaskasaš čatnosiin sihke sámenuoraid perspektiivvain sin oassálastimis bargomáilbmái.
Polar Peoples: Projections of the Arctic Population – executive summary
This executive summary examines the projected size, composition and geographic distribution of the population of the Arctic in the future, by examining the population projections carried out by the national and regional statistical offices in each of the Arctic regions. The executive summary is based on the Nordregio Working Paper, Polar Peoples in the Future: Projections of the Arctic Populations. Population projections are an input into population policy and are used by policymakers for a variety of planning purposes. Policymakers operating at different levels in the Arctic region should be aware of these population trends and able to plan for them.
Polar Peoples in the Future: Projections of the Arctic Populations
Projections of the future size, composition and distribution of the populations of the Arctic states and regions are useful for policymakers for planning purposes. This paper presents and analyses the most recent population projections undertaken for the Arctic states and regions. Global population growth is projected to continue rising, from the current total of 7.4 billion to 10 billion in 2055. The population of the Arctic, as defined here, is predicted to change little, with a projected population increase of just 1%. However, there will be considerable variation in growth rates among the Arctic regions. Among the Arctic regions of Alaska, Yukon, Nunavut, Iceland, Troms, Khanty-Mansiy okrug and Chukotka, substantial population increases are projected, amounting to more than 10% over the projection period specified for each. Nordland, Finnmark, Pohjoil-Pohjanmaa (North Ostrobothnia) and Nenets autonomous okrug are projected to experience a more modest rate of growth of between 5% and 10%. The population of the Northwest Territories, Greenland, the Faroe Islands, Västerbotten, Norrbotten, Lappi, Yamal-Nenets okrug, Yakutia and Kamchatka oblast are projected to remain roughly the same, neither growing nor declining by more than 5%. Kainuu in Finland, Karelia, Komi, Arkhangel'sk, Murmansk, and Magadan in Russia are projected to undergo reductions in population of more than 5% each. Common trends identified for nearly all Arctic regions in the future are aging populations, more balanced gender ratios between men and women, increased concentrations of population within larger urban settlements, and the depopulation of smaller settlements. Research for this article is part of a project entitled Polar Peoples: Past, Present, and Future. This is supported by a grant from the U. S. National Science Foundation, Arctic Social Sciences Program (award number PLR-1418272). I would like to thank Olivia Napper, graduate student in the Department of Geography at George Washington University, for creating the…
Atlas of population, society and economy in the Arctic
The Atlas of Population, Society and Economy in the Arctic provides an in-depth overview of the changes that are affecting populations in the circumpolar North. Continuous environmental, economic and social changes are currently underway in the Arctic regions. Global warming, for example, is challenging traditional livelihoods, accessibility and economic activities. The atlas presents a collection of standardised indicators that illustrate the state of the Arctic regions focusing on demography, society, economy, production, accessibility and infrastructure as well as physical conditions and resources in the Arctic. As part of Nunataryuk's research, this working paper examines the environmental challenges related to permafrost by combining geographical data with demographic data in order to describe coastal and inland settlements. Permafrost thaw is a challenge for many Arctic communities, as it has an impact on infrastructure, economy and the health of Arctic populations.
Social and Economic Resilience in the Bothnian Arc Cross-Border Region
What global and local risks and long-term challenges is the Bothnian Arc cross-border area exposed to? And how can societies and economies in this area anticipate and respond to them to ensure resilient long-term development paths? This report provides a background overview on resilience and the methodology applied. Moreover, the report provides a snapshot of resilience situation in the Bothnian Arc. The data and information gathered was collected by interviewing local people both in Swedish and Finnish sides. The report is written by Nordregio together with the Bothnian Arc association on behalf of the Nordic Thematic Group on Innovative and Resilient regions, set by the Nordic Council of Ministers from 2017 to 2020.
Enabling vulnerable youth in rural areas not in education, employment or training
This report concludes work within the Nordic Thematic Group on Sustainable Rural Regional Development as part of the Nordic Co-operation Programme on Regional Development 2017–2021. The working title of the project is "A rural perspective on spatial disparities of education and employment outcomes". Part of the curiosity that drove this project was to understand better the situation of vulnerable and marginalized youth in rural areas of Norden, which arose from the Nordic Arctic Working Group 2013–2017 where we identified some local and regional processes with serious mismatch problems relating to youth education and validity in the local and regional labour market. Placing YOUTH IN FOCUS is response to the Nordic Council of Minister's cross-sectional strategy on Children and Youth 2016–2022 as well as the Nordic Co-operation Programme for Regional Development and Planning 2017–2021. It stresses the importance of promoting social sustainability in relation to regional development. The Icelandic chair in 2019 has young people as one of three main priorities. It relates to SDG4, the fourth UN sustainable development goal, in that young people should have a key role in achieving the goal, they should be encouraged to actively participate in society and should have access to important decisions shaping the future (Norræna ráðherranefndin, 2018). Furthermore, the project also relates strongly to both European, Nordic and in some cases national policy emphasis on inclusive labour markets for youth with reduced functional capacities. This report concludes work within the Nordic Thematic Group on Sustainable Rural Regional Development as part of the Nordic Co-operation Programme on Regional Development 2017–2020. The working title of the project is "A rural perspective on spatial disparities of education and employment outcomes".
Bringing attention back to the city centre – six Nordic examples
Many small and medium-sized Nordic cities are dealing with challenges related to the role and development of their city centres. They use strategies related to urban planning, governance and business development, to aim for greater compactness, attractiveness, economic development and sustainability. What can we learn from the Nordic countries' different approaches to city-centre development? This policy brief summarises investigations in six small and medium-sized Nordic cities. The discourse and practice of contemporary urban planning focuses strongly on densification and the compact city as the ideal and model for sustainable development. In the Nordic countries as well as elsewhere in Europe, there is a pervasive urban norm associated with planning, development and lifestyles. According to this norm, the compact city, and life in this city, is sustainable, attractive and safe. In parallel with this, sprawling urbanism has come to symbolise the environmental, social and economic problems of contemporary cities. Added to this, the central part of a city is a limited space for which there are high expectations related to the urban norm, expectations that can be particularly challenging for smaller cities. Our studies indicate that appropriate city-centre development requires co-operation across sectors and actors, recognition of the regional role of the city core, and investment in both the city centre and its periphery to create a balance that attracts residents, visitors and consumers. The policy brief summarises a project funded by the Nordic Council of Ministers' Nordic Thematic Group on Sustainable Cities and Urban Development. The Nordic Thematic Group for Sustainable Cities and Urban Development 2017–2020 aims to help improve national, regional, local and cross-border strategies for sustainable cities. This is done via research projects and other communicative activities, addressing the following themes from the Nordic Co-operation Programme for Regional Development and Planning: 1) social sustainability and gender equality; 2)…
The Compact City of the North – functions, challenges and planning strategies
In this report, the characteristics and consequences of the compact city ideal in Nordic cities, and more specifically in their city centres, are investigated. The research was done in the form of a series of small case studies of city centre development, and they are presented thematically. They focus on public spaces and the threat from external shopping, densification as a planning strategy, new housing as a planning tool, and finally governance and actor collaboration. The Nordic region is dominated by small and medium sized cities, and we chose the following cities for our investigation of city centre challenges and planning strategies: Bodø (Norway), Kokkola (Finland), Mariehamn (Åland), Mosfellsbær (Iceland), Sorø (Denmark) and Västervik (Sweden). The cities were investigated through planning and policy documents, interviews and observations, and the work was guided by the following questions: What does "the compact city" mean in the investigated cities – and how is it operationalized? What are the main planning problems related to city centres, and what are the visions for the future in relation to these? What can we learn from different ways of approaching city centre development across the different Nordic countries? Two strong themes related to development in city centres, and to the commonly held view that the city core needs to be strengthened, regenerated or recreated, are competition from external shopping centres, and urban sprawl. These themes point to the challenges to the central city as the one and only centre. The examples from the Nordic region show that the competition from external shopping is very real, and that planning regulations do not always have the desired effect on the competition. This has led to a variety of responses – new central housing, new attractive spaces, new types of plans and new governance collaborations. In addition to their different…
Enhanced Labour Market Opportunities for Immigrant Women – Arctic case studies
Migration has been a major source of population increase in the Nordic countries for the past decades. Meanwhile, the employment gap between refugees and immigrants, on the one hand, and the native-born population on the other has increased. This report identifies policies and practices for enhancing access for immigrant women to the local labour market in the Arctic region. Different initiatives have been established to enhance labour market access for immigrants in the Nordic region, and some are specifically intended for women. Although there are similarities between the Nordic countries, it is not a homogeneous region in terms of labour market opportunities for immigrants, nor in terms of the proportion of immigrants in need of this access. At the same time, little research has been conducted to determine the effectiveness of the different measures in place. This publication is the outcome of a comparative study focusing on immigrant women's access to the labour market in small and medium-sized cities in the Arctic region. The study is funded by the Nordic Gender Equality Fund, which supports projects aimed at knowledge sharing and problem-solving with regards to gender equality across the Nordic countries. The research was carried out by the University of Akureyri, Nordregio and the University of Lapland.
Demographic change and labour market challenges in regions with large-scale resource-based industries in the Northern Periphery and Arctic
Low population density, low accessibility, low economic diversification and abundant natural resources are common characteristics of Northern Periphery and Arctic (NPA) areas. At the same time, ageing populations and the emigration of young people are key challenges facing many communities. The REGINA1) project provides local and regional practitioners with a deeper understanding of demographic and labour market trends and challenges in NPA regions in Finland, Greenland, Norway, Scotland and Sweden. Alongside social impact management and increasing local benefits associated with large-scale natural resource industries, 'demography and labour markets' form one of the three strategic planning pillars of the Local Smart Specialisation (LS3) concept, as developed in the REGINA project. This report describes this pillar from a planning and policy perspective. In Section One, the essential concepts and issues related to demography and labour markets are introduced, followed by an analysis of the current demographic and labour market situation in the communities participating in the REGINA project in Section Two. Sections Three and Four offer tools and approaches to help practitioners further understand the local demographic and labour market situation in their communities to support evidence-based policymaking. They describe examples of policies to improve demographic trends and labour market conditions that have been applied in other NPA communities and regions.


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Chuck Dodd has been leading tours along the Applegate-Lassen Trail, across the Black Rock Desert and through the High Rock Canyon in northwestern Nevada, and on to Goose Lake in northeastern California, since 1995. And he has been getting better at it every time he did it.
For information about Chuck's "Emigrant Experience" tours on the Applegate-Lassen Trail, Click Here.
Tour maps showing the location of the trail as well as the tour route.
Detail maps of tricky intersections and important trail sites and segments.
Quotations and sketches from diaries and journals written by the emigrants.
Color tour maps you can print for your use.
Color photos of the black-and-white photos in the printed guide.
Waypoints and tracks of the tour you can transfer to your GPS.
To facilitate its use, the guide is wire bound so you can open it flat.
Chuck Dodd's Guide to Traveling the Applegate-Lassen Trail. Charles H. Dodd. 19th Century Publications, 2009. 5½ by 8½ inches. 224 pages, with a Supplemental CD. $22.95.


Time for *Mindset Monday* and it's all about making choices.
There are a lot of things we do, that we don't love to do.
This is a complete lie. You don't have to do anything you don't want to do. You don't have to make sales calls, but you probably WANT to so that you can increase your profit.
You don't have to do the dishes, but you probably WANT to so that you have clean dishes to eat on.
Everything we do is a choice. If we want certain rewards or results, then we WANT to do what it takes to get those.
Starting now and for the rest of the week – think about all of the choices you make. When you find yourself feeling obligated doing something you "have to" do, you can remind yourself that it's a total lie. Do you want to do it? Why or why not? If you decide that you WANT to do it, then own that choice.
I want to go over the budget… so I can have money in the bank.
I want to do the laundry… so we have clean clothes to wear.
I even want to pay my taxes… so that I don't go to jail.
Don't be a victim. Be the creator of your life and success.
https://mollyclaire.com/wp-content/uploads/2016/10/mompreneur-success.jpg 333 500 Molly Claire /wp-content/uploads/2016/06/new-web-logo.png Molly Claire2016-10-01 17:09:042016-10-01 17:09:04Mompreneur, you never "have to."
Mom Life and Let's Get Breakfast Overwhelmed, Worried, Confused. Let's have cake, Mom.


text:
Privilege (Withdrawal Agreement: Legal Advice)
Part of the debate – in the House of Commons at 1:15 pm on 4th December 2018.
Bill Cash Chair, European Scrutiny Committee 1:15 pm, 4th December 2018
Just one moment. If there is a danger that the withdrawal agreement could be invalid, that is a matter of fundamental importance on which I would have expected the Attorney General to include his opinion, but there is no evidence whatsoever that he referred to that in his opinion, and that is why we need full disclosure. I also understand that there are sheaves of papers within governmental circles unpacking the repeal of the 1972 Act with respect to the prospective withdrawal and implementation Bill, which is again a matter of extreme public importance. By any standards, all these matters fall not only within the ministerial code, but within what I would have hoped and expected the Attorney General to deal with in his opinion and the statement he gave yesterday, but there was nothing there to give me any comfort whatsoever.
To say that we should move on and get real and that what the Attorney General thinks is in the national interest actually is in the national interest does also bear on the question of whether the European Union (Withdrawal) Act is a matter of extreme public interest and fundamental importance. The failure to address that question in the introduction and in the legal statement seems to be a mistake of the first order and, furthermore, to be inconsistent with what I would have expected from the legal opinion of the Attorney General.
As to the role of the Attorney General, I simply refer to the authoritative work "The Attorney General, Politics and the Public Interest", published in 1984 and written by Professor John Edwards. In his chapter dealing with ministerial consultations with the Law Officers, it is made clear that all legal advisers from all Departments will ultimately turn on the view of the Attorney General. Edwards states that there will be times when the Attorney General, perceiving the legal implications of a Department's proposed course of action—in this case, No. 10 and the Department for Exiting the European Union—will find it necessary to oppose a Minister's preferred policy. Such opposition must also derive from the legal implications of the proposed policy.
As Edwards says on page 190 of his authoritative work, for the Government to reject such advice would be quite exceptional and would reasonably lead to serious questioning by the Attorney General himself of his continuing to serve as the Government's chief legal adviser. Without full public disclosure of his opinion, it will be impossible to get to the bottom of all the considerations that are at the heart of the issue of public trust to which the former Secretary of State for Exiting the European Union referred regarding the manifesto and the reasons for his resignation and the conduct of the Government, to which I have referred myself in terms of broken promises made in the House recently.
The reason why my European Scrutiny Committee is making a full inquiry into this situation is, in a nutshell, because we want to get to the bottom of the conduct and the processes and the outcome of these negotiations, and we will do so by taking evidence. I trust that the Government will take note of the seriousness of the suggestions and the arguments that I am putting forward, because they go to the heart of public trust, the referendum vote itself, the repeal of the 1972 Act, whether the Attorney General has fully addressed the consequences for the withdrawal agreement of the opinion that he has given, which we have a right to see, and whether it is really in the public interest for it not to be disclosed.
(Citation: HC Deb, 4 December 2018, c674)


[Question] HELP!! What is the best product for cooling a RAM?
[Question] what is overclocking and modding?
40C idle with a zalman... WTF??
My mother in law's computer is getting HOT!
Why do you overclock your CPU?
Is it easy to put a game port?
How do you put your processor in?
Best AMD to overclock now?


Decadent Vapour concentrates are world-renowned, and are used by some of the best known brands in the UK and beyond. These concentrates are the actual flavour blends Decadent Vapours use to create their ranges of e-liquids. All are PG based and have been third party tested for diacetyl and acetyl propionyl.


I am in strong support of the bail reform provisions included in the Senate's comprehensive criminal justice bill, S.2185 – An Act relative to criminal justice reform.
Under our current cash-based bail system, we incarcerate too many individuals before their trial – not because they are likely to flee or pose a danger to society, but because they are poor and unable to afford their cash bail. A person's freedom should never be based on their ability to pay.
The Supreme Judicial Court's (SJC) recent decision in the Brangan case, which states that a court may not impose excessive cash bail that the court knows a person is unable to pay without a formal written or oral finding, is a significant step in the right direction. However, this decision alone does not address the full range of problems created by the Commonwealth's reliance on a cash-based bail system.