A custom eLearning solution that helps students to compile and publish personalized educational materials, compiled from the available content in different disciplines. All materials are available through the digital library. The online library allows students and teachers to compile personal eBooks or textbooks by simple adding the available content. Also, users can organize their content, search for a particular digital book, and share the created library with other users for viewing or editing.
Traditional forms of education have some drawbacks that can be corrected by technological means. For example, a technological solution can replace the physical data carriers such as books and brochures. Books are heavy and bulky, can be expensive or even out of stock. Libraries help students to solve this problem partially, but some issues remain unsolved. For example, books can become unusable with frequent use. Also, libraries are not available 24/7 which may cause inconvenience to some students.
Our developers were asked to develop an online digital library that would allow solving the described issues. The system should allow students and educators to create custom collections with the possibility to organize, search and share the content. Also, our customer asked to provide functionality requiring to work with a digital book's content. Users should have the possibility to make notes and search across the library of eBooks by keyword to find a particular term in a specific context.
Our custom web application development team has built an online system that allows both students and educators to compile, manage and share custom collections with others. Besides using the existing database of knowledge, the system allows teachers to create, share and use their own articles and notes.
Students can organize the available libraries, manage the content, and add covers with custom text to the eBooks. Teachers have the possibility to preview the collection online at any time, review the material, and make edits if needed. Also, each owner can share the created collection with colleges who can use it as-is or modify to adapt for the needs of their course.
Students can get access to the set of tools allowing to increase the efficiency of learning. There's the possibility to develop a unique study guide that contains custom-made digital books and other digital educational materials. Students can highlight text and make notes that will help to organize the learning and improve retention. Also, teachers can add their own notes to attract the attention of students to the most important topics.
Our developers used the Amazon S3 cloud platform for creating the online digital library. All educational materials are available in the PDF format.
To implement the fast conversion of PDF files to JPEG/PNG format developers have used the ImageMagick open-source software suite.
XB Software's development team has created a comprehensive online digital library that allows increasing the students' engagement in the educational process. Students and teachers can compile and share custom online collections of eBooks.
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American football team
Adam Augustyn
San Francisco 49ers, American professional gridiron football team based in Santa Clara, California, that plays in the National Football League (NFL). The 49ers have won five Super Bowl titles (1982, 1985, 1989, 1990, and 1995) and six National Football Conference (NFC) championships.
Jerry Rice scoring his 125th career touchdown, September 5, 1994. AP
The San Francisco 49ers were established in the All-American Football Conference (AAFC) in 1946. The team had a winning record in each of its first four years, but it could not displace the dominant Cleveland Browns, who won every championship in the four seasons of the AAFC. After the AAFC merged with the NFL in 1950, the 49ers struggled through their first losing season. Despite the presence of five future Hall of Famers—quarterback Y.A. Tittle, running backs Hugh McElhenny and Joe Perry, tackle Bob St. Clair, and defensive lineman Leo Nomellini—the 49ers were mostly unsuccessful during the 1950s, advancing to the postseason only once, in 1957. San Francisco began a string of 12 consecutive seasons without a play-off berth in 1958. One of the most noteworthy players on the team during the 1960s was running back Dave Kopay, who in 1977 became the first athlete from a major American team sport to publicly acknowledge that he was a homosexual. A resurgent 49ers squad under the guidance of head coach Dick Nolan and led by quarterback John Brodie advanced to the NFC championship game in both 1971 and 1972 but lost to the Dallas Cowboys on both occasions.
The 49ers ascendancy began in 1979 when quarterback Joe Montana was drafted by new head coach Bill Walsh. Upon his arrival in San Francisco, Walsh installed his innovative "West Coast offense," which relied on a series of quick, accurate passes and was a perfect fit for Montana's skills. San Francisco rebounded from a 2–14 record in Walsh's first year to the franchise's first Super Bowl win in his third. The 49ers' title run was highlighted by a last-second victory over the Cowboys in the NFC championship game off a brilliant touchdown pass from Montana to wide receiver Dwight Clark, which was immortalized as "The Catch." The 49ers lost to the Washington Redskins in the 1984 NFC championship game, but they lost only one game the following year and returned to the Super Bowl, where they easily defeated the Miami Dolphins. In the 1985 NFL draft, the team selected wide receiver Jerry Rice, who would team with Montana to create one of the most prolific passing duos in NFL history on his way to breaking every major career receiving record. After guiding the 49ers to a third Super Bowl win in 1989, Walsh retired and handed head-coaching duties to his defensive coordinator, George Seifert.
Bill Walsh. © Jerry Coli/Dreamstime.com
While the 49ers teams of the 1980s were best known for their offensive prowess, their defense featured a number of star players, including future Hall of Fame safety Ronnie Lott. San Francisco's dominance on both sides of the ball was evidenced in 1990, when the 49ers defeated the Denver Broncos 55–10 in the most lopsided Super Bowl victory of all time. An injury to Montana in 1991 gave Steve Young an opportunity to step in as the 49ers' starting quarterback. Young excelled in his new role, which allowed the 49ers to trade Montana in 1993, and the team won a fifth Super Bowl in 1995. Young's retirement in 1999 marked a symbolic end to the 49ers' long reign atop the NFL—the team had qualified for the postseason in 15 of the 16 seasons between 1983 and 1998—and San Francisco struggled to field a consistently competitive team through the first decade of the 21st century.
In 2011 first-year head coach Jim Harbaugh guided a young 49ers team built around a ferocious defense to the team's first play-off appearance since 2002; it ended in an NFC championship game loss to the New York Giants. The next year the 49ers defeated the Atlanta Falcons in the NFC championship game to return to the Super Bowl for the first time in 18 years. However, San Francisco was defeated by the Baltimore Ravens 34–31. Following the 2013 season, the 49ers returned to a third consecutive NFC championship game (the third time that the franchise had hit that mark of sustained excellence in its history), but the team lost a close contest to its division-rival Seattle Seahawks.
In 2014 the 49ers moved 48 miles (77 km) southeast of their namesake city to a new stadium and team headquarters in Santa Clara. That season saw the end of the team's streak of play-off berths as the 49ers finished 8–8, and, after reports of friction between the coach and front office dogged the franchise all season, Harbaugh and the team mutually agreed to part ways at the end of the year. The team's play drastically fell off following Harbaugh's departure: the 49ers posted four consecutive seasons with double-digit losses.
gridiron football: Birth and early growth of professional football
the Cleveland Browns, San Francisco 49ers, and a first version of the Baltimore Colts to an expanded NFL in 1950. Yet professional football could offer the public nothing comparable to the compelling rivalries, youthful enthusiasm, and colourful pageantry of college football. It was only in the 1950s with…
San Francisco: Popular culture
…team was the gridiron football 49ers, who began play in 1946. The team became one of the most successful in National Football League history, winning five Super Bowl titles. San Francisco became, along with Los Angeles, one of the first two West Coast cities to be home to a Major…
…a one-year contract with the San Francisco 49ers for the 1994 season, during which he was named NFL Defensive Player of the Year after making six interceptions (returning three for touchdowns) and helped the team to a decisive victory in Super Bowl XXIX. In 1995–96 he won another Super Bowl…
Ronnie Lott
John Henry Johnson
Bob St. Clair
areas of involvement
Pro Football Hall of Fame - San Francisco 49ers
Official Site of San Francisco 49ers
Britannica Websites
Articles from Britannica Encyclopedias for elementary and high school students.
San Francisco 49ers - Student Encyclopedia (Ages 11 and up)

redpajama_set_name: RedPajamaCommonCrawl


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A Phase I Clinical Trial of Guadecitabine and Carboplatin in Platinum-Resistant, Recurrent Ovarian Cancer: Clinical, Pharmacokinetic, and Pharmacodynamic Analyses.
A Randomized, Open-Label, Phase II Study Comparing Pemetrexed Plus Cisplatin Followed by Maintenance Pemetrexed versus Pemetrexed Alone in Patients with Epidermal Growth Factor Receptor (EGFR)-Mutant Non-small Cell Lung Cancer after Failure of First-Line EGFR Tyrosine Kinase Inhibitor: KCSG-LU12-13.
A comparison of débridement with and without anconeus muscle flap for treatment of refractory lateral epicondylitis.
A multicenter study of recombinant human interleukin 12 for the treatment of chronic hepatitis C virus infection in patients nonresponsive to previous therapy.
A phase I dose escalation study of Ad GV.EGR.TNF.11D (TNFerade™ Biologic) with concurrent chemoradiotherapy in patients with recurrent head and neck cancer undergoing reirradiation.
A phase II evaluation of brivanib in the treatment of persistent or recurrent carcinoma of the cervix: An NRG Oncology/Gynecologic Oncology Group study.
ACR appropriateness criteria retreatment of recurrent head and neck cancer after prior definitive radiation expert panel on radiation oncology-head and neck cancer.
Acceptance of repeat esophagogastroduodenoscopy to detect gastric cancer in a Chinese immigrant cohort.
American Society of Radiation Oncology recommendations for documenting intensity-modulated radiation therapy treatments.
Analysis of outcomes following failed endovascular treatment of chronic limb ischemia.
Are different methotrexate regimens as first line therapy for low risk gestational trophoblastic neoplasia more cost effective than the dactinomycin regimen used in GOG 0174?
Arterial access site and outcomes in patients undergoing percutaneous coronary intervention with and without vorapaxar.
Arteriovenous Graft Delamination and Dissection as a Cause of Graft Dysfunction.
Autologous Dendritic Cell-Cytokine Induced Killer Cell Immunotherapy Combined with S-1 Plus Cisplatin in Patients with Advanced Gastric Cancer: A Prospective Study.
Bendamustine, pomalidomide, and dexamethasone for relapsed and/or refractory multiple myeloma.
CASE 11-2016 Perioperative Coronary Thrombosis in a Patient With Multiple Second-Generation Drug-Eluting Stents: Is It Time for a Paradigm Shift?
Clinical Outcomes and Patient-Matched Molecular Composition of Relapsed Medulloblastoma.
Clinical characteristics associated with poor long-term survival among patients with diabetes mellitus undergoing saphenous vein graft interventions.
Colon Cancer, Version 1.2017, NCCN Clinical Practice Guidelines in Oncology.
Comparative effectiveness of drug-eluting stents on long-term outcomes in elderly patients treated for in-stent restenosis: a report from the National Cardiovascular Data Registry.
Comparison of medicine alone, coronary angioplasty, and left internal mammary artery-coronary artery bypass for one-vessel proximal left anterior descending coronary artery disease.
Complete longitudinal analyses of the randomized, placebo-controlled, phase III trial of sunitinib in patients with gastrointestinal stromal tumor following imatinib failure.
Complete revascularisation in ST-elevation myocardial infarction and multivessel disease: meta-analysis of randomised controlled trials.
Consensus Treatment Plans for Chronic Nonbacterial Osteomyelitis Refractory to Nonsteroidal Antiinflammatory Drugs and/or With Active Spinal Lesions.
Dexamethasone intravitreal implant in previously treated patients with diabetic macular edema: subgroup analysis of the MEAD study.
Diagnosing coronary arterial stent thrombosis and arterial closure.
Discontinuing mechanical ventilatory support: removing positive pressure ventilation vs removing the artificial airway.
Economic impact of GPIIB/IIIA blockade after high-risk angioplasty: results from the RESTORE trial. Randomized Efficacy Study of Tirofiban for Outcomes and Restenosis.
Effectiveness and Downstream Healthcare Utilization for Patients That Received Early Physical Therapy Versus Usual Care for Low Back Pain: A Randomized Clinical Trial.
Efficacy and Safety of Durvalumab in Locally Advanced or Metastatic Urothelial Carcinoma: Updated Results From a Phase 1/2 Open-label Study.
Evolving practice pattern changes and outcomes in the era of hybrid aortic arch repair.
Four-year survival with nivolumab in patients with previously treated advanced non-small-cell lung cancer: a pooled analysis.
Heterogeneity of Second-Line Treatment for Patients With Multiple Myeloma in the Connect MM Registry (2010-2016).
Imaging-guided percutaneous thrombin injection for the treatment of iatrogenic femoral artery pseudoaneurysms.
Improvement in quality of life with left prefrontal transcranial magnetic stimulation in patients with pharmacoresistant major depression: acute and six month outcomes.
Influence of a randomized clinical trial on practice by participating investigators: lessons from the Coronary Angioplasty Versus Excisional Atherectomy Trial (CAVEAT). CAVEAT I and II Investigators.
Kidney Cancer, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology.
Laser in infrapopliteal and popliteal stenosis 2 study (LIPS2): Long-term outcomes of laser-assisted balloon angioplasty versus balloon angioplasty for below knee peripheral arterial disease.
Management of recurrent prostate cancer after radiotherapy: long-term results from CALGB 9687 (Alliance), a prospective multi-institutional salvage prostatectomy series.
NCCN Guidelines Insights: Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Version 1.2017.
NCCN Guidelines Insights: Melanoma, Version 3.2016.
Neuroform stent-assisted embolization of incidental anterior communicating artery aneurysms: long-term clinical and angiographic follow-up.
Observational study of the development of diabetic macular edema following panretinal (scatter) photocoagulation given in 1 or 4 sittings.
Outcomes based on plasma biomarkers in METEOR, a randomized phase 3 trial of cabozantinib vs everolimus in advanced renal cell carcinoma.
Outcomes of patients with acute coronary syndromes and prior percutaneous coronary intervention: a pooled analysis of three randomized clinical trials.
Patient-preferred sites of restylane injection in periocular and facial soft-tissue augmentation.
Pelvic Floor Disorders Registry: Study Design and Outcome Measures.
Per-Oral Pyloromyotomy (POP) for Medically Refractory Post-Surgical Gastroparesis.
Percutaneous repair or surgery for mitral regurgitation.
Phase 2 and 3 clinical trial of oral bexarotene (Targretin capsules) for the treatment of refractory or persistent early-stage cutaneous T-cell lymphoma.
Phase I Study of the Investigational Aurora A Kinase Inhibitor Alisertib plus Rituximab or Rituximab/Vincristine in Relapsed/Refractory Aggressive B-cell Lymphoma.
Phase I/II dose-escalation study of PI3K inhibitors pilaralisib or voxtalisib in combination with letrozole in patients with hormone-receptor-positive and HER2-negative metastatic breast cancer refractory to a non-steroidal aromatase inhibitor.
Phase I/II study of the novel proteasome inhibitor delanzomib (CEP-18770) for relapsed and refractory multiple myeloma.
Phase II, randomized, placebo-controlled study of dovitinib in combination with fulvestrant in postmenopausal patients with HR+, HER2- breast cancer that had progressed during or after prior endocrine therapy.
Plasma Vascular Endothelial Growth Factor Concentrations after Intravitreous Anti-Vascular Endothelial Growth Factor Therapy for Diabetic Macular Edema.
Platelet inhibition with cangrelor in patients undergoing PCI.
Prior chemoradiotherapy adversely impacts outcomes of recurrent and second primary head and neck cancer treated with concurrent chemotherapy and reirradiation.
Pulmonary stenting for the treatment of sarcoid induced pulmonary vascular stenosis.
Pump replacement for left ventricular assist device failure can be done safely and is associated with low mortality.
RADIANCE: a randomized controlled study of ranibizumab in patients with choroidal neovascularization secondary to pathologic myopia.
Radiation dose-volume effects in the spinal cord.
Ranibizumab for treatment of neovascular age-related macular degeneration: a phase I/II multicenter, controlled, multidose study.
Reimplantation of a fluocinolone acetonide sustained drug delivery implant for chronic uveitis.
Reinterventions in the superficial femoral artery.
Reirradiation for recurrent head and neck cancer.
Relationship Between Operator Volume and Long-Term Outcomes After Percutaneous Coronary Intervention.
Repeat revascularization after contemporary percutaneous coronary intervention: an evaluation of staged, target lesion, and other unplanned revascularization procedures during the first year.
Results of a 5-year multicenter trial of a new generation cooled high energy transurethral microwave thermal therapy catheter for benign prostatic hyperplasia.
Retreatment with talimogene laherparepvec for advanced melanoma.
Retreatment with telaprevir combination therapy in hepatitis C patients with well-characterized prior treatment response.
Rising PSA Level in an Anxious Postprostatectomy Patient.
Risk-benefit trade-offs in revascularisation choices.
Routine postoperative imaging is important after ureteroscopic stone manipulation.
SCORE Study report 3: study design and baseline characteristics.
Segment Length in Cine Strain Analysis Predicts Cardiac Resynchronization Therapy Outcome Beyond Current Guidelines.
Selective inhibition of FLT3 by gilteritinib in relapsed or refractory acute myeloid leukaemia: a multicentre, first-in-human, open-label, phase 1-2 study.
Simultaneous restenosis of Taxus and Cypher drug-eluting stents.
Sirolimus (rapamycin) for the treatment of steroid-refractory acute graft-versus-host disease.
Six-month outcomes of percutaneous coronary balloon angioplasty in acute coronary syndromes: Results from the PURSUIT trial.
Stress imaging use and repeat revascularization among medicare patients with high-risk coronary artery disease.
Success and failure are dynamic, recurrent event states after surgical treatment for pelvic organ prolapse.
Successful conversion from conventional immunosuppression to anti-CD154 monoclonal antibody costimulatory molecule blockade in rhesus renal allograft recipients.
T-DM1 Activity in Metastatic Human Epidermal Growth Factor Receptor 2-Positive Breast Cancers That Received Prior Therapy With Trastuzumab and Pertuzumab.
Technical innovation. Using a cutting balloon to treat resistant high-grade dialysis graft stenosis.
Techniques and benefits of multiple internal mammary artery bypass at 20 years of follow-up.
Telaprevir for previously treated chronic HCV infection.
Temporal trends in percutaneous coronary intervention outcomes among older patients in the United States.
The Association of Previous Revascularization With In-Hospital Outcomes in Acute Myocardial Infarction Patients: Results From the National Cardiovascular Data Registry.
The Effect of Clinical Care Location on Clinical Outcomes After Peripheral Vascular Intervention in Medicare Beneficiaries.
The Use of Re-irradiation in Locally Recurrent, Non-metastatic Rectal Cancer.
The truth and consequences of the COURAGE trial.
Third-Line Nivolumab Monotherapy in Recurrent SCLC: CheckMate 032.
Toward individualized post-electroconvulsive therapy care: piloting the Symptom-Titrated, Algorithm-Based Longitudinal ECT (STABLE) intervention.
Training, detraining, and retraining: Two 12-week respiratory muscle training regimens in a child with infantile-onset Pompe disease.
Transcranial magnetic stimulation in the treatment of major depressive disorder: a comprehensive summary of safety experience from acute exposure, extended exposure, and during reintroduction treatment.
Transplantation outcomes for severe combined immunodeficiency, 2000-2009.
Trastuzumab emtansine versus capecitabine plus lapatinib in patients with previously treated HER2-positive advanced breast cancer (EMILIA): a descriptive analysis of final overall survival results from a randomised, open-label, phase 3 trial.
Treatment of central venous in-stent restenosis with repeat stent deployment in hemodialysis patients.
Treatment of infected tunneled venous access hemodialysis catheters with guidewire exchange.
Treatment of neovascular age-related macular degeneration with intravitreal bevacizumab: efficacy of three consecutive monthly injections.
Treatment selection in metastatic renal cell carcinoma: more confusion or a path forward?
Trends in age-related macular degeneration management in Singapore.
Umbralisib, a novel PI3Kδ and casein kinase-1ε inhibitor, in relapsed or refractory chronic lymphocytic leukaemia and lymphoma: an open-label, phase 1, dose-escalation, first-in-human study.
Update of the international consensus on palliative radiotherapy endpoints for future clinical trials in bone metastases.
Use of ranolazine in patients with incomplete revascularization after percutaneous coronary intervention: design and rationale of the Ranolazine for Incomplete Vessel Revascularization Post-Percutaneous Coronary Intervention (RIVER-PCI) trial.
Use of stress testing and diagnostic catheterization after coronary stenting: association of site-level patterns with patient characteristics and outcomes in 247,052 Medicare beneficiaries.
Use of the Instantaneous Wave-free Ratio or Fractional Flow Reserve in PCI.
Vorapaxar in the secondary prevention of atherothrombotic events.
White Blood Cell Count and Major Adverse Cardiovascular Events After Percutaneous Coronary Intervention in the Contemporary Era: Insights From the PARIS Study (Patterns of Non-Adherence to Anti-Platelet Regimens in Stented Patients Registry).
Keywords of People
Brennan, J. Matthew, Associate Professor of Medicine, Medicine, Cardiology
Buckley, Rebecca Hatcher, James Buren Sidbury Distinguished Professor of Pediatrics, in the School of Medicine, Immunology
Fekrat, Sharon, Professor of Ophthalmology, Ophthalmology, Vitreoretinal Diseases & Surgery
Mithani, Suhail Kamrudin, Associate Professor of Surgery, Orthopaedics
Preminger, Glenn Michael, James F. Glenn, M.D. Distinguished Professor of Urology, Surgery, Urology
Woodward, Julie Ann, Professor of Ophthalmology, Dermatology


The game this week was 4-man team best ball where each team was required to take 1 or more balls on odd holes and exactly 2 balls on even holes. There were 2 Flights using the ABCD format for each foursome.
Easily winning Flight 1 by 5 strokes with a -28 score was the team of Ned Mahoney, John Evans, Steve Skipper, and a Blind Draw of Bob Murphy. Flight 2 was an even bigger run-away where the winning team of John Schwonke, Dave Resler, Bob Hainly, and Bob Kaplan won by 9 points with a score of -33. We presume that handicap audits are underway for both winning teams.
Regarding net Skins, there were a total of 5 Skins awarded to 5 different winners. And Peter Quinn is no longer a rookie "Skins Meister", having now organized his second Skins competition. Thanks, Peter!!! And while pace-of-play was good, there was a clear "winner" for DFL low score. Coming in with a -8 was the foursome of Charlie Bradford, Rufus Freeman, Grant Buchanan, and Herb Gallagher, the only team not to make it to double-digits. And we presume that handicap audits are not underway for these 4 players.
So, congratulations to all our winners. And don't forget to sign up for next Thursday's play. It will be at Palmetto with a 4-man team Stableford competition. Teams will have all A or B or C or D players on each team, and the teams will be flighted by handicaps. And as always, liquid refreshments will be provided at the 19th hole.


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Sam and John were out cutting wood when John accidentally cut his arm off. Sam remained calm, wrapped the arm securely in a plastic bag, and immediately took John and his arm to a surgeon.
"You're in luck," said the surgeon. "I am an expert in re-attaching limbs. Come back in four hours when I have completed the operation."
So Sam returned in four hours and the surgeon said, "I did it faster than I expected. John is down at the pub."
Sam rushed down to the pub and was amazed to see John playing darts with his newly re-attached arm.
A few weeks later, Sam and John were out cutting wood again when John accidentally cut his leg off.
Having some experience with this type of situation, Sam put the leg snugly in a plastic bag and took it and John back to the same surgeon.
"Legs are a bit harder," said the surgeon, "but I'll see what I can do – come back in six hours."
Sam returned in six hours and the surgeon said, "I finished early – John's out playing football."
Sam went to the field and to his surprise found John kicking 50 meter torpedoes.
A few weeks later, Sam and John were cutting wood again, when John accidentally cut off his own head. (John was a rather clumsy individual.)
Sam put the head in a plastic bag, tied it tightly, and took it, and the rest of John to the surgeon, confident that the skillful surgeon could do the job.
"Gee, heads are very difficult to re-attach," the surgeon muttered, "but I'll see what I can do – come back in 12 hours."
Sam returned in 12 hours.
"How did it go, Doc?" he asked.
"I'm sorry, Sam, but John died," the surgeon replied.
Aghast, Sam asked, "But how did he die? I thought you were an expert surgeon!"
"I'm afraid you suffocated him with the plastic bag."


Alana Rivera, California artisan and creator of Etta + Billie always considered herself a "foodie" and body product obsessed. After realizing a career in PR wasn't the right fit for her, she set out to create a skincare line that was based off of her love of food and drink and consisted of natural ingredients. In 2011, Etta + Billie became the first body care line to be a certified green business in the San Francisco area.
Originally from northern California, Alana came from a small outdoorsy area where she was an avid garden, animal, and food lover. She moved to San Francisco after college where she started a career in PR. She was already making soap in her free time, referencing "The Natural Soap Making" book that was a Christmas gift from her mother. The first batch of soap she remembers making was a lavender soap, which now she considers her favorite to make due to its simple recipe and symbolism of the beginning of her journey with Etta + Billie.
In 2013, Alana officially quit her job to make soap full time in her one bedroom apartment. She relied heavily on her recipe book, her certificate in herbalism (which she received in 2008), as well as taking some classes. Then in 2014, she moved into her first manufacturing space where she could really focus on creating her product.
"I keep a notebook of my ideas. A lot of my inspiration is food related," Alana said. "I'll sketch out the look of the soap and write down all the ingredients before getting started."
Once Alana has a recipe, she starts by creating an oil mixture and a lye mixture. Once these are both in a liquid state, she combines them until they reach just the right consistency. The soap is then ready for the ingredients which include a wide variety of essential oils, dried herbs, and sometimes fruits depending on the recipe. Once all the ingredients are incorporated thoroughly, she then pours the mixture into a mold. When the soap is poured Alana will then add any texture elements or additional botanicals, such as poppy seeds or coffee to the soap before wrapping it in a blanket to maintain heat.
When in the covered mold, the soap goes from a batter like state to a softer bar that can be easily cut. This process can take anywhere from 24-48 hours. Once the batch has been cut into individual bars, they cure for about 4-6 weeks. The batch then receives a batch number and is boxed up by hand and is then ready for purchase. While Etta + Billie's lip balms and body oils have a simpler creation process than the soap they smell just as lovely. Alana works to source all high quality natural ingredients from all over the world to create her products.
"The most important thing I want people to know about Etta + Billie is that it's very fulfilling and challenging work," Alana said. "These products are made with the hope that it's going to make someone's day. I want my products to bring someone to a good head place, wherever that may be."
When they're not making batches of soap, Alana and her team participate in local givebacks. They donate both time and money to a food bank in the San Francisco area, as well as a youth literacy program called 826 Valencia.


This is an electric version of Mitsubishi's i-city car and now the standard petrol engine of this vehicle is unavailable in the UK. However, the electric version is here and ready to be driven by environmentally conscious motorists but how does it compare to its rivals?
The i-MiEV was one of the first electric cars to go on sale in the UK and while it has a reasonable amount of interior space, it is much smaller than the Nissan Leaf. This is hardly surprising since it is a city car and is designed for use in narrow streets. The silent electric motor would allow you to creep along almost unnoticed if it wasn't for the standout design of the vehicle.
The i-MiEV has a high roofline so there is lots of room inside for passengers in the front and back of the vehicle. You will only be able to fit two people in the back seat so be wary of this if you are seeking a 5-seater model. The 227 litre boot is far from being spacious but it should be large enough for most people's needs.
The combustion engine and fuel tank of the i-city car have been replaced by a 200kg battery pack and electric motor with 63bhp. The i-MiEV excels when it comes to the stop-start nature of city driving as it pulls away nice and smoothly and handles well. While it is not suited for rural use, it is fun to use on a short jaunt into the countryside as it is capable of keeping up with traffic.
The range is said to be in the 80-100 mile arena but this depends on how you drive. For example, the range will be dramatically reduced if you have the air-conditioning on at full power. The i-MiEV charges in 7 hours from a mains supply but this decreases to 30 minutes if you possess a 50kW three-phase supply.
The Mitsubishi i-MiEV is one of the better four-seater city cars on the market that produce zero emissions. Its low centre of gravity allows for good body control and it performs extremely well in high traffic situations. On the downside, it is expensive for what you get and the Nissan Leaf offers more power for a slightly higher price.


text:
Bosnia : U.S. military operations, Steven R. Bowman
The Resource Bosnia : U.S. military operations, Steven R. Bowman
The item Bosnia : U.S. military operations, Steven R. Bowman represents a specific, individual, material embodiment of a distinct intellectual or artistic creation found in Boston University Libraries.
Bowman, Steven R
Library of Congress, Congressional Research Service
In Paris on December 14, 1995, the presidents of Bosnia, Croatia, and Serbia signed the peace settlement they negotiated in Dayton, OH. Nations Security Council's Resolution 1031 authorized for one year the multilateral NATO-led implementation force (IFOR) under the U.N. Charter's Chapter VII. On December 12, 1996, the Security Council authorized a follow-on force, dubbed the Stabilization Force (SFOR). In March 1998, the NATO allies agreed that SFOR will remain in Bosnia until significant progress, according to specified benchmarks, has been made in the implementation of the Dayton Accords. All NATO nations contributed personnel, along with 18 non-NATO nations, for an IFOR total of about 54,000 troops. With SFOR's duration now dependent upon progress in implementing the Dayton Accords, NATO commanders have lent greater assistance to civilian authorities, local and international, in their efforts to create a stable political environment. SFOR has stepped up efforts to detain war crimes suspects, provided logistical support for internationally monitored elections, and provided limited assistance for refugee resettlement. Contrary to some initial expectations when NATO deployed to Bosnia, the IFOR/SFOR operations have been notably free of hostile casualties. In keeping with congressional direction, costs for Balkan peacekeeping operations after FY2002 will no longer be separately budgeted, but rather will be covered by the individual armed services regular operating budgets
Washington, D.C., Congressional Research Service, Library of Congress, 2001
Title from title screen
"Updated March 30, 2001."
Bosnia : U.S. military operations
U.S. military operations
Steven R. Bowman
IFOR (Organization)
United States -- Armed Forces -- Bosnia and Herzegovina
Dayton Peace Accords (1995)
Military assistance, American -- Bosnia and Herzegovina
Military assistance, American
CRS issue brief, IB93056
CRS issue brief
IB93056
Computer file characteristics
Electronic document.
Hein Online
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 Data from Bosnia : U.S. military operations, Steven R. Bowman - Boston University Libraries

Data Citation of the Item Bosnia : U.S. military operations, Steven R. Bowman
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http://library.link/portal/Bosnia--U.S.-military-operations-Steven-R./YIgm_3t6lsQ/


text:
Stephen J. Sherman Funeral Home
Albert T. Bellucci, Farrell, PA
FARRELL, Pennsylvania (MyValleyTributes) – Albert T. Bellucci, 84, passed away peacefully on Sunday, December 12, 2021 at Saint John XXIII Home in Hermitage, Pennsylvania following an extended illness.
Albert was born on April 7, 1937 in Farrell, Pennsylvania to Alfonso and Angeline (Caputo) Bellucci.
He graduated from Farrell High School in 1955 and went on to graduate from barber school in Erie, Pennsylvania.
Farrell High School Alumni Tributes
He was also in the Army in Washington state.
After coming home from the Army, he opened up Al's Barber Shop in Wheatland, Pennsylvania. He also worked for Aqua Water Co., where he retired from in 1999.
His greatest hobby was making wine. He also enjoyed traveling, especially taking tours and cruises. Most of all, he enjoyed taking summer vacations with his family to the Outer Banks. He enjoyed taking his grandpuppies, Musket, Maggie, Hailey, Grace and Charlie for their walks.
Albert is survived by his wife, Rose (Hranko) Bellucci to whom he was married for 55 years; a son, Christopher (Julie) Bellucci of West Middlesex; a daughter, Stephanie (Shane) Henning of Matthews, North Carolina; a grandson, Aidan Bellucci of Akron, Ohio and granddaughters, Rachael Bellucci of West Middlesex, Pennsylvania and Allyson Henning of Matthews, North Carolina.
He was preceded in death by his parents and a brother, Julius Bellucci.
Memorial contributions may be sent to Our Lady of Fatima Church, 601 Roemer Blvd., Farrell, PA 16121 or to a charity of your choice.
Friends may call Thursday, December 16, 2021 from 4:00 – 6:00 p.m. in the Sherman Funeral Home & Crematory, 2201 Highland Road, Hermitage, PA 16148. A funeral service will follow at 6:00 p.m. in the funeral home with Father Matthew Ruyechan officiating.
Burial will take place in Our Lady of Fatima Cemetery.
To send flowers to the family or plant a tree in memory of Albert T. Bellucci, please visit our floral store.
A television tribute will air Wednesday, December 15 at the following approximate times: 7:10 a.m. on FOX, 12:22 p.m. on WKBN, 5:08 p.m. on MyYTV and 7:27 p.m. on WYTV.


text:
'use strict';

(function() {
	// Expense entries Controller Spec
	describe('Expense entries Controller Tests', function() {
		// Initialize global variables
		var ExpenseEntriesController,
		scope,
		$httpBackend,
		$stateParams,
		$location;

		// The $resource service augments the response object with methods for updating and deleting the resource.
		// If we were to use the standard toEqual matcher, our tests would fail because the test values would not match
		// the responses exactly. To solve the problem, we define a new toEqualData Jasmine matcher.
		// When the toEqualData matcher compares two objects, it takes only object properties into
		// account and ignores methods.
		beforeEach(function() {
			jasmine.addMatchers({
				toEqualData: function(util, customEqualityTesters) {
					return {
						compare: function(actual, expected) {
							return {
								pass: angular.equals(actual, expected)
							};
						}
					};
				}
			});
		});

		// Then we can start by loading the main application module
		beforeEach(module(ApplicationConfiguration.applicationModuleName));

		// The injector ignores leading and trailing underscores here (i.e. _$httpBackend_).
		// This allows us to inject a service but then attach it to a variable
		// with the same name as the service.
		beforeEach(inject(function($controller, $rootScope, _$location_, _$stateParams_, _$httpBackend_) {
			// Set a new global scope
			scope = $rootScope.$new();

			// Point global variables to injected services
			$stateParams = _$stateParams_;
			$httpBackend = _$httpBackend_;
			$location = _$location_;

			// Initialize the Expense entries controller.
			ExpenseEntriesController = $controller('ExpenseEntriesController', {
				$scope: scope
			});
		}));

		it('$scope.find() should create an array with at least one Expense entry object fetched from XHR', inject(function(ExpenseEntries) {
			// Create sample Expense entry using the Expense entries service
			var sampleExpenseEntry = new ExpenseEntries({
				name: 'New Expense entry'
			});

			// Create a sample Expense entries array that includes the new Expense entry
			var sampleExpenseEntries = [sampleExpenseEntry];

			// Set GET response
			$httpBackend.expectGET('expense-entries').respond(sampleExpenseEntries);

			// Run controller functionality
			scope.find();
			$httpBackend.flush();

			// Test scope value
			expect(scope.expenseEntries).toEqualData(sampleExpenseEntries);
		}));

		it('$scope.findOne() should create an array with one Expense entry object fetched from XHR using a expenseEntryId URL parameter', inject(function(ExpenseEntries) {
			// Define a sample Expense entry object
			var sampleExpenseEntry = new ExpenseEntries({
				name: 'New Expense entry'
			});

			// Set the URL parameter
			$stateParams.expenseEntryId = '525a8422f6d0f87f0e407a33';

			// Set GET response
			$httpBackend.expectGET(/expense-entries\/([0-9a-fA-F]{24})$/).respond(sampleExpenseEntry);

			// Run controller functionality
			scope.findOne();
			$httpBackend.flush();

			// Test scope value
			expect(scope.expenseEntry).toEqualData(sampleExpenseEntry);
		}));

		it('$scope.create() with valid form data should send a POST request with the form input values and then locate to new object URL', inject(function(ExpenseEntries) {
			// Create a sample Expense entry object
			var sampleExpenseEntryPostData = new ExpenseEntries({
				name: 'New Expense entry'
			});

			// Create a sample Expense entry response
			var sampleExpenseEntryResponse = new ExpenseEntries({
				_id: '525cf20451979dea2c000001',
				name: 'New Expense entry'
			});

			// Fixture mock form input values
			scope.name = 'New Expense entry';

			// Set POST response
			$httpBackend.expectPOST('expense-entries', sampleExpenseEntryPostData).respond(sampleExpenseEntryResponse);

			// Run controller functionality
			scope.create();
			$httpBackend.flush();

			// Test form inputs are reset
			expect(scope.name).toEqual('');

			// Test URL redirection after the Expense entry was created
			expect($location.path()).toBe('/expense-entries/' + sampleExpenseEntryResponse._id);
		}));

		it('$scope.update() should update a valid Expense entry', inject(function(ExpenseEntries) {
			// Define a sample Expense entry put data
			var sampleExpenseEntryPutData = new ExpenseEntries({
				_id: '525cf20451979dea2c000001',
				name: 'New Expense entry'
			});

			// Mock Expense entry in scope
			scope.expenseEntry = sampleExpenseEntryPutData;

			// Set PUT response
			$httpBackend.expectPUT(/expense-entries\/([0-9a-fA-F]{24})$/).respond();

			// Run controller functionality
			scope.update();
			$httpBackend.flush();

			// Test URL location to new object
			expect($location.path()).toBe('/expense-entries/' + sampleExpenseEntryPutData._id);
		}));

		it('$scope.remove() should send a DELETE request with a valid expenseEntryId and remove the Expense entry from the scope', inject(function(ExpenseEntries) {
			// Create new Expense entry object
			var sampleExpenseEntry = new ExpenseEntries({
				_id: '525a8422f6d0f87f0e407a33'
			});

			// Create new Expense entries array and include the Expense entry
			scope.expenseEntries = [sampleExpenseEntry];

			// Set expected DELETE response
			$httpBackend.expectDELETE(/expense-entries\/([0-9a-fA-F]{24})$/).respond(204);

			// Run controller functionality
			scope.remove(sampleExpenseEntry);
			$httpBackend.flush();

			// Test array after successful delete
			expect(scope.expenseEntries.length).toBe(0);
		}));
	});
}());

redpajama_set_name: RedPajamaGithub


text:
Studentenwebsite (24)
Medewerkerswebsite (47)
Vacatures (15)
Geesteswetenschappen (7)
Governance and Global Affairs (5)
Rechtsgeleerdheid (5)
Sociale Wetenschappen (10)
Wiskunde en Natuurwetenschappen (421)
495 zoekresultaten voor "lipid metabolism" in de Publieke website
Protein arginine methyltransferases as modulators of lipid metabolism and inflammation and the relevance for atherosclerosis Onderzoeksoutput
Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…
Cholesterol metabolism in mouse models of atherosclerosis and adrenal steroidogenesis Onderzoeksoutput
Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.
Polymers in the Liver: Metabolism and Regulation Onderzoeksproject
Metabolic diseases are a burden on the European population and health care system. It is increasingly recognised that individual differences with respect to history, lifestyle, and genetic make-up affect disease progression and treatment response. A Systems Medicine approach, based on computational…
Cardiovascular and Metabolic Therapeutics BioTherapeutics
This research group, headed by Miranda van Eck, focusses on understanding the molecular mechanisms underlying cardiovascular and metabolic diseases. Cardiovascular disease constitutes a major health issue worldwide. Although significant knowledge has been obtained on the development of atherosclerotic…
Lipid mediated colloidal interactions Onderzoeksoutput
The lipid membrane is a basic structural component of all living cells. Embedded in this nanometer-thin barrier, membrane proteins shape the membrane and at the same time respond to the shape of the membrane.
Superstructures of lipids and graphene Onderzoeksoutput
This thesis systematically analyzes the physical-chemistry of lipid-graphene interactions with the major objective of reconciliating the variety of results reported in the literature.
Chemical tools to study lipid signaling Onderzoeksoutput
Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.
On the geometry of demixing: A study of lipid phase separation on curved surfaces Onderzoeksoutput
Like a mixture of oil and water, lipid membranes separate into two liquid phases.
Lipid bilayers decorated with photosensitive ruthenium complexes Onderzoeksoutput
Promotor: E. Bouwman, Co-promotor: S. Bonnet
The important role of stratum corneum lipids for the cutaneous barrier function Onderzoeksoutput
The skin protects the body from unwanted influences from the environment as well as excessive water loss. The barrier function of the skin is located in the stratum corneum (SC).
Phase behavior of skin lipid mixtures: the effect of cholesterol on lipid organization Onderzoeksoutput
The lipid matrix in the stratum corneum (SC), the upper layer of the skin, plays a critical role in the skin barrier. The matrix consists of ceramides (CERs), cholesterol (CHOL) and free fatty acids (FFAs).
Cholesterol metabolism and hematopoiesis interaction in atherothrombosis Onderzoeksoutput
Cardiovascular disease is the leading cause of death worldwide.
Modulation of Stratum Corneum Lipid Composition and Organization of Human Skin Equivalents by Specific Medium Supplements Onderzoeksoutput
Our in-house human skin equivalents contain all stratum corneum (SC) barrier lipid classes, but have a reduced level of free fatty acids (FAs), of which a part is mono-unsaturated. These differences lead to an altered SC lipid organization and thereby a reduced barrier function compared to human skin.…
Cutaneous barrier dysfunction in atopic eczema: the role of stratum corneum lipids Onderzoeksoutput
Source: International Journal of Cosmetic Science, Volume 37, Number 1, pp. 148-148 (2015) ISBN: 0142-5463
Studies on molecular basics of metabolic syndrome in zebrafish Onderzoeksoutput
The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.
Lipids as therapeutic targets for barrier repair in skin diseases Onderzoeksoutput
The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.
Lipid signaling in brain diseases Leiden Early Drug Discovery & Development
Multiple Sclerosis, Parkinson's and Alzheimer's disease are the most common neurodegenerative disorders. Unfortunately, no effective treatments are currently available to halt the progression of these neuroinflammatory diseases [1].
Modulating energy metabolism Agenda - 16 maart 2023
Dyslipidemia, metabolism and autophagy: antigen-independent modulation of T cells in atherosclerosis Onderzoeksoutput
Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.
Visualization of Vitamin A Metabolism Onderzoeksoutput
Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.
Human epidermal lipid biosynthesis in health and disease Onderzoeksproject
How are the epidermal lipid pathways involved in health and disease.
scale clearance from adults to children for drugs undergoing hepatic metabolism? Onderzoeksoutput
The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.
Human skin equivalents: understanding the lipid biosynthesis in the skin Onderzoeksproject
There is considerable need for improved skin models to develop safe and efficient drugs for skin delivery as well as for cosmetic and chemical product testing on the skin.
Junior Technician for Metabolic Engineering Vacature
Wiskunde en Natuurwetenschappen, Instituut Biologie Leiden (IBL)
Metabolic Characterization of Marine Sponge Onderzoeksproject
Which metabolites of sponge are influenced by individual environmental or biological factors?
mRNA and drug delivery with lipid-based nanoparticles Onderzoeksoutput
This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.
ceramide chain length distribution on the barrier properties of the skin lipid membranes Onderzoeksoutput
The skin barrier function is provided by the stratum corneum (SC). The lipids in the SC are composed of three lipid classes: ceramides (CERs), cholesterol (CHOL) and free fatty acids (FFAs) which form two crystalline lamellar structures. In the present study, we investigate the effect of CER chain length…
Towards artificial photosynthesis on the lipid bilayer of liposomes Onderzoeksoutput
Artificial photosynthesis has recognised potential to produce green and sustainable fuels from earth-abundant resources such as water, carbon dioxide (CO2), and sunlight.
Insights from modeling metabolism and amoeboid cell motility in the immune system Onderzoeksoutput
This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.
Coiled-coils on lipid membranes: a new perspective on membrane fusion Onderzoeksoutput
Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros
The interplay between lipids and the immune system in atherosclerosis Onderzoeksoutput
Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.
distribution affects permeability barrier function of stratum corneum lipid model membranes Onderzoeksoutput
Virus-host metabolic interactions: using metabolomics to probe oxidative stress, inflammation and systemic immunity Onderzoeksoutput
Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken
Chemical biology of glucosylceramide metabolism fundamental studies and applications for Gaucher disease Onderzoeksoutput
This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).
Lipid chain length reduction correlates with the skin barrier function in atopic eczema patients and inflammation plays a role in the altered Onderzoeksoutput
Source: Journal of Investigative Dermatology, Volume 135, pp. S59-S59 (2015)
The synthesis of chemical tools for studying sphingolipid metabolism Onderzoeksoutput
Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.
Preclinical validation of putative targets in cardiovascular and metabolic disease Onderzoeksoutput
Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.
Lipid to protein ratio plays an important role in the skin barrier function of atopic eczema patients Onderzoeksoutput
The barrier function of the skin is primarily provided by the stratum corneum (SC), the outermost layer of the skin. Skin barrier impairment is thought to be a primary factor in the pathogenesis of atopic eczema (AE).
Lipid model membrane systems as a tool for unraveling the underlying factors for skin barrier dysfunction Onderzoeksoutput
Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.
The role of lipids in the barrier function of the skin Onderzoeksproject
The outermost layer of the skin, the stratum corneum (SC), is responsible for the skin barrier function, protecting the body from pathogens, chemicals and other unwanted substances from the external environment. The SC lipid matrix provides the only continuous pathway through the SC and is considered…
Understanding the physical properties that affect the lipid organization in the skin barrier Onderzoeksproject
It is the aim of this project to better understand how the physical properties of lipids influences the structure and overall barrier function of the skin.
Intercellular Skin Barrier Lipid Composition and Organization in Netherton Syndrome Patients Onderzoeksoutput
Netherton Syndrome (NTS) is a rare genetic skin disease caused by mutations in the serine protease inhibitor Kazal-type 5 gene, which encodes the lympho-epithelial Kazal-type-related inhibitor. NTS patients have a profound impaired skin barrier function. Because SC lipids play a crucial role in the…
systems for studying the impact of organic chemicals on the skin barrier lipids Onderzoeksoutput
This paper describes two synthetic lipid models designed to replace human stratum corneum (SC) in studies of the impact of volatile organic chemicals on the molecular organization of the skin barrier lipids.
Skin Lipids: Localization of Ceramide and Fatty Acid in the Unit Cell of the Long Periodicity Phase Onderzoeksoutput
The lipid matrix of the skin's stratum corneum plays a key role in the barrier function, which protects the body from desiccation. The lipids that make up this matrix consist of ceramides, cholesterol, and free fatty acids, and can form two coexisting crystalline lamellar phases: the long periodicity…
Gaining control of lipid-based nanomedicine by understanding the nano-bio interface Onderzoeksoutput
Dit proefschrift beschrijft een collectie aan alternatieve strategieën voor het begrijpen, ontwerpen en toepassen van lipide nanosystemen, waarin de rol van de bio-nano interacties centraal staan. In het bijzonder wordt gekeken naar de interactie van RNA-lipide nanosystemen, bekend van de toepassing…
Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition Onderzoeksoutput
Diacylglycerol lipases (DAGLα and DAGLβ) convert diacylglycerol to the endocannabinoid 2-arachidonoylglycerol. Our understanding of DAGL function has been hindered by a lack of chemical probes that can perturb these enzymes in vivo.
Ecology and genomics of Actinobacteria and their specialised metabolism Onderzoeksoutput
Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.
Membrane Fusion Mediated Intracellular Delivery of Lipid Bilayer Coated Mesoporous Silica Nanoparticles Onderzoeksoutput
Alexander Kros and co-workers describe how mesoporous silica nanoparticles (MSNs) are delivered into cells via membrane fusion thereby omitting endocytosis pathways. Fusion is induced by a pair of complementary coiled-coil lipopeptides inserted into the membrane of cells and in the bilayer of lipid-coated…
Combined LC/MS-platform for analysis of all major stratum corneum lipids, and the profiling of skin substitutes Onderzoeksoutput
Ceramides (CERs), cholesterol, and free fatty acids (FFAs) are the main lipid classes in human stratum corneum (SC, outermost skin layer), but no studies report on the detailed analysis of these classes in a single platform.
The importance of free fatty acid chain length for the skin barrier function in atopic eczema patients Onderzoeksoutput
An important feature of atopic eczema (AE) is a decreased skin barrier function. The stratum corneum (SC) lipids - comprised of ceramides (CERs), free fatty acids (FFAs) and cholesterol - fulfill a predominant role in the skin barrier function.


text:
Q: how to limit the amount of digits of a function in Julia my function has to work with very big numbers, so in order to do that I used parts in my code such as big() . Unfortunately this resulted in giving me a result that is too precise (in other words its slowing the entire code down).
This is how the result looks like.
ΔE = 0.08298347005140644564908076516066986088852555871299296314640532293721884964540988

If possible I would like to limit the result to 4 digits
ΔE = 0.0829

A: If performance is a concern, probably the best way to do this is with https://github.com/dzhang314/MultiFloats.jl, e.g.
using MultiFloats
x = Float64x4(2.0)
# Calculations performed on x will have Float64x4 precision subsequently...

MultiFloats.jl appears to be the fastest package around at present for such calculations, and will let you choose from precision levels between Float64x2 and Float64x8. In any event, this will be dramatically faster than the BigFloats used in the example above.

redpajama_set_name: RedPajamaStackExchange


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text:
110th Congress (2007-2008) (15)
450 - Community/Regional Development (4)
(-) 550 - Health (15)
700 - Veterans' Benefits/Services (1)
750 - Administration of Justice (3)
800 - General Government (5)
House Committee on Energy and Commerce (14)
House Committee on Natural Resources (1)
(-) House Committee on the Budget (1)
(-) House Committee on Ways and Means (3)
(-) Senate Committee on Health, Education, Labor, and Pensions (11)
S. 911, Conquer Childhood Cancer Act of 2007
Cost Estimate December 19, 2007
Cost estimate for the bill as reported by the Senate Committee on Health, Education, Labor, and Pensions on December 12, 2007
S. 1916, Chimp Haven is Home Act
Cost Estimate December 5, 2007
Cost estimate for the bill as ordered reported by the Senate Committee on Health, Education, Labor, and Pensions on November 14, 2007
H.R. 1424, Paul Wellstone Mental Health and Addiction Equity Act of 2007
Cost estimate for the bill as ordered reported by the House Committee on Ways and Means on September 26, 2007
H.R. 3580, Food and Drug Administration Amendments Act of 2007
Cost Estimate September 26, 2007
Direct spending and revenues effects estimate for the bill as cleared by the Congress on September 20, 2007
S. 898, Alzheimer's Breakthrough Act of 2007
Cost estimate for the bill as reported by the Senate Committee on Health, Education, Labor, and Pensions on August 3, 2007
S. 1183, Christopher and Dana Reeve Paralysis Act
Cost Estimate September 6, 2007
H.R. 3162, Children's Health and Medicare Protection Act of 2007
Cost estimate for the bill as ordered reported by the Committee on Ways and Means on July 27, 2007
S. 1693, Wired for Health Care Quality Act
Cost estimate for the bill as ordered reported by the Senate Committee on Health, Education, Labor, and Pensions on June 27, 2007
S. 793, Reauthorization of the Traumatic Brain Injury Act
S. 1011, a bill to change the name of the National Institute on Drug Abuse to the National Institute on Diseases of Addiction and to change the name of the National Institute on Alcohol Abuse and Alcoholism to the National Institute on Alcohol


Playworks is initiating a competition for the upper grades to earn new equipment and painted lines for their playground area.
There will be a watch and check every day for the following things: 1-Playground balls and equipment are put away in baskets after each bell. 2-No coats, gloves, scarves, or lunch-boxes are on the ground or hanging on fences. 3-No garbage is on the ground after you play. 4-People are helping to put equipment away after the 6th grade recess.


ultimate week noticed the release of the iPhone 7 and seven Plus, and as is always the case with new handsets, they're offered out. however if you have one of the two editions, are you presently taking part in what they ought to offer in the manner of wallpapers?
whether or not you love Apple or no longer, one issue you could say is that their wallpaper artwork is the pleasant. This time round, they have got used what look like photographs of different coloured floating liquid as first-birthday party wallpapers. you can have visible them: black background with a black iPhone 7 and a liquid colored blob inside the center. these were the wallpapers Apple used in its promotions for the two handsets, and in overall, there are five hues.
generally, first-birthday celebration iphone hd wallpapers may be pretty uninspiring. however, this time, round, Apple has created something that appeals to many. So these wallpapers have made their way onto the internet. these static wallpapers are available on the iPhone 7 or iPhone 7 Plus or, in fact, any handset. they have got a resolution of 1242 x 2208 and look very sharp.
in case you need to search out all 5 of the static iPhone 7 wallpapers, absolutely everyone can do so from here.
however what if you don't want the primary-party coloured blob wallpapers? There are a few options if you head over to pixelstalk; they have wallpapers for the iPhone 7 and the Jet Black 7 Plus.
In reality, among the wallpapers at the web page are unfastened to down load and mostly aimed at users who have a Jet Black handset.
known as the Drop iPhone and 7 Plus JetBlack for iPhone HD, this wallpaper is loose, as are others on the site.
The above iPhone 7 Jet Black dye wallpaper is likewise unfastened for every person to use. however, there are a few commands which you need to read ahead.
The solar eclipse wallpaper above is an example of different terrifi wallpapers you could find for the iPhone 7. again, I suppose this wallpaper was designed mainly for the black iPhones, however it's going to more than probably grow to be on various handsets.
Step 1: find a wallpaper that you like and click on it to view a bigger photo.
Step 2: subsequent, right-click and pick out shop picture as. this may permit you to download the wallpaper for your laptop.
as a substitute, if you are studying this / travelling PixelStalk via your mobile tool, press or faucet at the photo and select save photograph as; this may down load the wallpaper for your tool.
And that's it; you currently have get entry to to two sets of wallpapers in your iPhone 7 or 7 Plus. but, you don't definitely need to have one yet to get these wallpapers. just use a Mac or windows computer or even an older iPhone and preserve them secure for whilst your iPhone 7 turns up.


As in previous years, Spain will be represented by a large number of companies at Sial Paris 2014. A total of 215 Spanish companies will attend the event, which will be organized into 8 halls with a total area of 3,500 m2, according to ICEX Spain Export and Investment. The fair will be held at the North Paris-Villepinte Exposition Park from October 19th to the 23rd.
This is ICEX's 18th event with an official pavilion, which serves as a meeting point for leading Spanish participants. The three Spanish regions with the greatest amount of participating companies are Extremadura, with 21, Castile-La Mancha, with 15, and Castile-León, with 13.
However, companies from other regions, such as Catalonia and Valencia, among others, are also participating outside the official pavilion.
In terms of sector segments, this year there are 111 general food companies participating, 25 companies specialized in baked goods, 19 in charcuterie, 15 in beverages, 14 in dairy products, 13 in gourmet products, and 9 in fresh and 9 in frozen meat products.
Spain is once again one of the countries with the largest presence at Sial Paris; at the previous edition, it ranked fourth in terms of participants, behind France, Italy and Turkey.
The Spanish products being showcased at the event stand out in terms of quality, among other aspects. Participating companies and associations include Gullón, Paellas Gastraval, Central Lechera Asturiana, Interporc, Juver, Oleostepa, Aceites La Española, Coosur, Aceitunas Torrent, Pescamar, La Vieja Fábrica, Helios, el Gaitero, Apis, PGI Cordero de Extremadura, Quesos El Casar, Golden apples, and García Baquero.
In total, 85% of exhibitors are international companies.
This will be the 26th edition of Sial Paris, a general food fair (processed and fresh foods, wines and other beverages) held every two years exclusively for sector professionals. This year more than 6,300 exhibitors will attend, bringing together a wide range of food sector suppliers. Companies are coming from 105 countries and 85% of exhibitors are international names. There will be 20 product sectors and food channels and 150,000 visitors, a large portion of which are from different countries around the world.
Sial, which is celebrating its 50th anniversary, has positioned itself as one of the largest agri-food sector events featuring top-flight products and companies.
Sial 2014 will also be unique in terms of its new structure, organized into 20 sectors, with one new addition: Equipment and Technology, the goal of which is to encourage the flow of visitors and optimize networking.


Sensation is a mix of annual cosmos varieties with pink, purple, burgundy and white flowers. Early blooming varieties. Fern-like foliage. Grows to 1m tall. 12-14 weeks to flowering. 70 seeds per packet.
Cosmos is native to Mexico.
Sensation cosmos produces large, single flowers up to 10cm across that are held upright above the foliage and come in a mix of colours from dark burgundy and purple through to pale pink and white. Cosmos flowers will help attract beneficial predatory and pollinator insect species to your garden. Cosmos flowers are suitable for use in flower arrangements, although are short-lived once cut. Sensation cosmos was an All-America Selections (AAS) award winning variety in 1936. Cosmos is an easily grown, showy annual flower, it's a perfect species to grow if you want to nurture an interest in gardening in children and novice gardeners alike. While ideal for planting into mixed borders and cottage gardens, cosmos is also suitable for growing in larger containers if garden bed space is limited.
Sensation cosmos grows best in temperate areas, but is adaptable to a range of climates and growing conditions. Cosmos flowers best when grown in full sun, however gardeners in warmer climates may prefer to plant cosmos in light shade to reduce heat stress on plants during the hottest parts of the day. Cosmos grows well in poorer soils. Cosmos grows tall so place them towards the rear if planting in mixed garden beds. To create bushy, multi-branching plants pinch out the central growing tip early on, leaving at least several pairs of leaves for new branches to grow out from the base of. If cosmos plants become too leggy and start falling over they can be pruned back hard and they'll re-shoot. Growing cosmos together in blocks will cause their foliage to inter-twine, this will help the plants support each other and keep them upright. Water cosmos plants regularly to prevent the fern-like foliage from wilting. Deadhead spent cosmos flowers regularly to promote additional bud formation. Cosmos may self-sow in the garden if growing conditions are ideal and spent flowers are left on the plants to spread seeds. Cosmos isn't affected by any serious pest or disease issues.
In cold and mountainous regions of Australia sow Sensation cosmos seeds from mid Spring to mid Summer. In temperate regions of Australia sow Sensation cosmos seeds from early Spring to mid Summer. In subtropical regions of Australia sow Sensation cosmos seeds from late Winter to late Spring. In tropical regions of Australia sow Sensation cosmos seeds during the dry season, from mid Autumn to late Winter is best.
Cosmos seeds should be sown 6mm deep, spacing plantings about 25cm apart to give their root systems room to spread while still being close enough to allow a solid carpet of cosmos flowers to form once mature.
Cosmos seeds can be slow to germinate, with most seedlings emerging from the soil 14 to 20 days after sowing the seeds.
Cosmos plants are fast growers and are quick to flower, expect your first flower buds 12 to 14 weeks after sowing the seed. Sensation is one of the earliest flowering mixes of cosmos and will continue to bloom all the way through the growing season.


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Saturday, July 18, 2020 Posted by Matthew Larosiere
This week in gun rights – July 18, 2020
Matthew Larosiere is the Director of Legal Policy at Firearms Policy Coalition. You can connect with him on Twitter @MattLaAtLaw.
New assault-weapon-hungry grabbers backing candidates
Ban Assault Weapons Now, a "grass-roots coalition of concerned Floridians," with committee members like David Hogg—the precocious young scamp who serves as the most recognizable face of the recent push to disarm Floridians. Before this week, BAWN was mostly engaged in encouraging citizen-led lobbying efforts, but now it is joining the ranks of organizations like Everytown and other Bloomberg-backed groups, turning to financial influence of political elections. According to the group's announcement, BAWN will be funding campaign contributions and supporting "targeted communication for candidates who pledge to push legislation that bans assault weapons."
Here's hoping BAWN keeps up their track record of fumbling and self-sabotage, but if anything this is evidence that the grabbers are not losing steam. The under-21 ban in Florida promises to do irreparable harm to gun culture in the state, so vigilance is essential.
Bloomberg pricing out the Pennsylvania Legislature, and why you can't trust politicians
In the midst of our fight with grabbers and the City of Pittsburgh to secure the right of Yinzers to keep and bear arms as they see fit, and as protected by the Second Amendment and Pennsylvania's Uniform Firearms Act, Bloomberg has announced that he intends to commit at least $1,000,000 to flip the state legislature. In 2018, Everytown rained cash on contested seats, bringing their candidates ever-closer to achieving a simple majority in the legislature's lower house. The lesson learned here thus seems to be that if you can't fight your way through the courts or sell your poison to current legislators, the solution is to install new, more agreeable members. Just so you know how serious this is, according to this quarterly FEC report, the PAC has at least $19,000,000 at their disposal. That's enough for a good bit of campaigning, with much of this money coming from Steve Balmer, owner of the L.A. Clippers.
Of course, everyone ought be able to spend whatever money they want on whatever cause they want. But we need to make sure that we get the truth out there to counter whatever these ghouls are cooking up. That means everything from donating to 2A orgs to bringing your most reasonable
Meanwhile, in New Mexico, we have Representative Xochitl Torres Small, who was supposed to be a sort of blue-dog democrat, advocating for the more mainstream economic and social positions of the DNC while also supporting the Second Amendment. Representative Torres Small even went as far to use a shotgun to do some live action roleplaying as a hunter for one of her campaign ads. After a narrow win, guess what she did. Turned coat, supporting universal background checks and anti-gun legislation. Imagine my shock. Worse yet, she's hired a former Everytown employee as her campaign manager. So remember, no matter what your politicians promise, unless they're saying they want to repeal the NFA and that everybody should own a tank, they're probably not to be trusted.
Judge issues ruling expanding the scope of evidentiary search into Remington case
You might remember the Connecticut case, Soto v. Bushmaster, an absurd case where the plaintiffs were allowed to ignore the Protection of Lawful Commerce in Arms Act and try to sue Bushmaster for someone's criminal misuse of product. The theory advanced by plaintiffs being that Bushmaster advertised the product as being meant for criminal purposes.
Well, upset by progress in the discovery process for the Connecticut Bushmaster case (Soto v. Bushmaster), Judge Barbara N. Bellis issued an order chastising the defendants, insisting that their objection to the plaintiff's demand that ALL Remington employee's documents must be turned over was unreasonable. Judge Bellis said "the obligation to act in good faith and provide documents within their knowledge, possession, or power rests on the defendants, and it is fair game for the plaintiffs to discover whether the defendants met their obligations."
Of course, bad discovery requests are common in this type of litigation. Plaintiffs are keen to go on fishing expeditions looking for some "smoking gun." However, we often see the requests clarified or narrowed under objection, given the considerable expense that Remington, a company that is currently undergoing its second bankruptcy, will have to bear in order to produce a bunch of documentation which may yield zero evidence supporting the plaintiffs' claims. Nonetheless, it will be interesting to see how this case turns out, especially considering no court has ever held a firearm manufacturer liable for the criminal misuse by a consumer.
Victory in Virginia for young adults
As the Supreme Court explained in District of Columbia v. Heller, the handgun is the quintessential firearm for self-defense in modern America, so of course the new Virginia Legislature would vote to restrict the right to access them for young adults; people old enough to carry a Beretta 9mm on watch in the military, but apparently not old enough to have one at their bedside.
The law in question was the state's new universal background check requirement, which requires all firearms transfers to be conducted by a federal firearms licensee. A background check in and of itself wouldn't prevent someone between the ages of 18 and 20 from purchasing a handgun, but by requiring the transfer to occur via an FFL, these adults would be unable to acquire handguns because FFLs are not permitted under yet another unconstitutional federal law to transfer handguns to individuals under 21. Thankfully, a Virginia judge took note of this, finding that the law as it applies to those under 21 is unconstitutional, the result being—for now—a bar on enforcing that provision as against 18-20 year olds trying to buy a handgun. Though the state is likely to appeal in short order. We need people to acknowledge at a national level that young adults have a right to self-defense too. Wins like these are a step in the right direction.


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Starting this Halloween, Cemetery Dance founder and publisher Richard Chizmar will be re-reading ALL of Stephen King's books in the order of publication, starting with Carrie, and posting his thoughts about the experience.
Use the sign-up box to the right to be notified of new posts and updates when this site goes live!
This is great. So glad I can be along for the ride!!


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Q: Unhandled Exception with Azure serviceBusService I'm trying to send a serviceBusQueue message from an API function in my Azure mobile-service and even though it successfully creates the queueService and the queue exists I get a nasty exception.  Any clue how I fix this?
I've attached the send code and stack trace.
function sendBusMessage(request, params, message, success)
{
  console.log(params);
  var queueService = azure.createServiceBusService(params.namespace,params.key);
  console.log(queueService);
  if (queueService)
  {
    queueService.sendQueueMessage('worker', message, function (error)
    {
        if (!error)
        {
            success();
        }
        else
        {
            request.respond(statusCodes.INTERNAL_SERVER_ERROR,error);
        }
    });
  }
}

Exception stack:
An unhandled exception occurred. TypeError: Cannot set property 'body' of null
    at ServiceClient._performRequest.self._buildRequestOptions.operation (D:\home\site\wwwroot\node_modules\azure\lib\services\core\serviceclient.js:210:34)
    at ServiceClient._performRequest (D:\home\site\wwwroot\node_modules\azure\lib\services\core\serviceclient.js:264:7)
    at ServiceBusService.ServiceClient._initDefaultFilter.filter (D:\home\site\wwwroot\node_modules\azure\lib\services\core\serviceclient.js:534:7)
    at ServiceClient._performRequest (D:\home\site\wwwroot\node_modules\azure\lib\services\core\serviceclient.js:261:10)
    at ServiceBusServiceClient._buildRequestOptions (D:\home\site\wwwroot\node_modules\azure\lib\services\core\servicebusserviceclient.js:107:5)
    at Wrap.signRequest (D:\home\site\wwwroot\node_modules\azure\lib\services\serviceBus\wrap.js:69:5)
    at WrapTokenManager.getAccessToken (D:\home\site\wwwroot\node_modules\azure\lib\services\serviceBus\wraptokenmanager.js:76:5)
    at WrapService.wrapAccessToken.finalCallback (D:\home\site\wwwroot\node_modules\azure\lib\services\serviceBus\wrapservice.js:98:7)
    at ServiceClient._initDefaultFilter.filter (D:\home\site\wwwroot\node_modules\azure\lib\services\core\serviceclient.js:538:11)
    at WrapService.wrapAccessToken.processResponseCallback (D:\home\site\wwwroot\node_modules\azure\lib\services\serviceBus\wrapservice.js:101:5)

A: Namespace
The namespace for configuring Node.js is the one visible under Service Bus tab (that is pretty straightforward).
Access Key
Unfortunately it can be easily confused with access keys defined for the specific messaging capability instances (such as queues). Providing an invalid access key may result in a stacktrace like the one in question.
The access key which should be used for configuring Node.js is the one accessible from the Connection Information window. To get there, you need to navigate to the Service Bus main tab (one with the cloud icon), then click Connection Information button available from the bar at the bottom. It is the Default Key right beneath the DEFAULT ISSUER section.
Configuring Namespace and Access Key
Both namespace and access key can either be passed to azure.createServiceBusService() function directly, or (when configuring a Mobile Service) set via AZURE_SERVICEBUS_NAMESPACE and AZURE_SERVICEBUS_ACCESS_KEY keys in the app settings configuration section.

A: Make sure you are using the top level configuration from the Service Bus->Namespace not anything deeper in the tree. An incorrect access key will not throw a useful exception (like "Can't use a queue key to access a namespace") but instead produces the problem above.