My feelings about Wither seemed to imitate the movement of a pendulum. One moment, I would swing one way and find myself completely invested, the next I would swing back in the opposite direction and find myself starting to lose interest. How did the book fare as a whole? Overall, when it was all said and done, I landed on the invested side.What drew me to this book originally was not the dystopian content (which I am generally a fan of), but the subject of polygamy. It's no secret that I've always had a fascination with polygamy. I love peering in the windows of people living completely different lifestyles, and discovering the inner workings of their mind. I was hoping that this book would be chock full of polygamy conflict.Instead, much of the focus was spent on main character's inner thoughts of escape, which in this instance, I didn't find myself caring much about. The first person present tense style of writing made for a slightly choppy read, but once I got used to it, I didn't notice it anymore.When the story finally started to delve into the intricacies of the polygamous marriage that Rhine had been forced into, things quickly became interesting. I was extremely disturbed at the creepy vibe being put out by the 20 year old House Governor (the husband) and the fact that he was all too eager to take the youngest bride of 13 to bed and get her pregnant. The way that he hovered over her and called her his "love" gave me a serious case of the willies. But, that's how polygamy can (and quite often does) happen, so I can't act like this shocks me.I'm usually able to find something likeable about the underdog, but in this case, I had a very hard time liking the husband, even though you find out pretty early on that he is just as much a victim as anyone else in the circumstance. It's apparent that he genuinely cares for his wives, but he also has no real moral trigger to let him know when his behavior is a bit skeevy. There was one scene where he was practicing every position of the Kama Sutra with his oldest wife (19), just because he felt like she needed to get pregnant, even though that particular wife didn't even like him, and that scene made me want to slap him.Did I like the book? Yes. Was I fond of the entire book? Absolutely not. Will I read the next one? Most definitely.


Maybe, Im just not over the holidays being over or i'm just super excited for Valentines day? Either way, Single Awareness Day is coming up in a few weeks. I found this fun check list online, a checklist of all the things to do before Valentines Day! Whether you're single or not, it's a fun list to fulfill!


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IndieNext
Home » The Maze Runner (Maze Runner, Book One) (Kobo...
The Maze Runner (Maze Runner, Book One) (Kobo eBook)
By James Dashner
The first book in the blockbuster phenomenon The Maze Runner series now features chapters from the highly-anticipated series conclusion, The Fever Code, the book that finally reveals the story of how the maze was built!
When Thomas wakes up in the lift, the only thing he can remember is his name. He's surrounded by strangers—boys whose memories are also gone.
Outside the towering stone walls that surround them is a limitless, ever-changing maze. It's the only way out—and no one's ever made it through alive.
Then a girl arrives. The first girl ever. And the message she delivers is terrifying.
Remember. Survive. Run.
The Maze Runner and Maze Runner: The Scorch Trials are now major motion pictures featuring the star of MTV's Teen Wolf, Dylan O'Brien; Kaya Scodelario; Aml Ameen; Will Poulter; and Thomas Brodie-Sangster. The third movie, Maze Runner: The Death Cure, will hit screens in 2018.
Also look for James Dashner's edge-of-your-seat MORTALITY DOCTRINE series!
Praise for the Maze Runner series:
A #1 New York Times Bestselling Series
A USA Today Bestseller
A Kirkus Reviews Best Teen Book of the Year
An ALA-YASLA Best Fiction for Young Adults Book
An ALA-YALSA Quick Pick
"[A] mysterious survival saga that passionate fans describe as a fusion of Lord of the Flies, The Hunger Games, and Lost."—EW.com
"Wonderful action writing**—fast-paced**…but smart and well observed."**—**Newsday
"[A] nail-biting must-read."**—**Seventeen.com
"Breathless, cinematic action."—Publishers Weekly
"Heart pounding to the very last moment."—Kirkus Reviews
"Exclamation-worthy."—Romantic Times
"James Dashner's illuminating prequel [The Kill Order] will thrill fans of this Maze Runner [series] and prove just as exciting for readers new to the series."—Shelf Awareness, Starred
"Take a deep breath before you start any James Dashner book."-Deseret News
Publisher: Delacorte Press
Publication Date: October 5th, 2009
Kobo eBook (September 18th, 2014): $7.99
Paperback (August 24th, 2010): $9.99
Hardcover (October 6th, 2009): $18.99
Prebound (August 24th, 2010): $20.80
Paperback (Spanish) (January 1st, 2010): $15.99
Prebound (Spanish) (January 1st, 2010): $28.15
Hardcover (August 5th, 2014): $17.99
Paperback (Vietnamese) (February 1st, 2013): $40.56
Kobo eBook (Spanish) (December 13th, 2015): $7.99
Paperback (August 5th, 2014): $10.99
Library Binding (October 6th, 2009): $19.99
CD-Audio (August 4th, 2015): $24.99
Paperback (August 1st, 2011): $15.50
Kobo eBook (Spanish) (April 30th, 2013): $7.99
Compact Disc (October 6th, 2009): $44.00
Search for books now!
All Special Orders, Author Events Admission Packages and Author Autographed Book Sales are final and nonrefundable at time of purchase, all other Sales are exchangeable/refundable within 30 Days with Receipt.

redpajama_set_name: RedPajamaCommonCrawl


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Nea Salamina Famagusta (Grieks: Νέα Σαλαμίνα Αμμοχώστου) is een Cypriotische sportclub uit Larnaca. De club werd in 1948 opgericht in Famagusta. De club is het meest bekend om zijn voetbalafdeling maar is ook actief in volleybal en is daar succesvoller dan in voetbal.

Voetbalafdeling

De club bereikte in 1955 voor het eerst de hoogste klasse en verblijft daar sindsdien met soms korte afwezigheden. De club kon nooit kampioen worden maar werd wel enkele malen derde (1956, 1966, 1993, 1995).

In 1974 bezette Turkije het noorden van Cyprus en moest de club uitwijken naar Larnaca, net als stadsgenoot Anorthosis.

Het grootste succes haalde de club in 1990 toen de beker werd gewonnen in de finale tegen Omonia Nicosia. Daarna speelde de club de supercup tegen kampioen APOEL Nicosia en won ook deze wedstrijd.

Erelijst (mannen)
 Beker van Cyprus
Winnaar: 1990
Finalist: 1966, 2001
Supercup
Winnaar:1990
Cypriotische Tweede Divisie
Winnaar :1955, 1980, 2002, 2004

Erelijst (vrouwen)
 Supercup : 2008

Nea Salamina in Europa
 #Q = #kwalificatieronde, #R = #ronde, Groep = groepsfase, T/U = Thuis/Uit, W = Wedstrijd, PUC = punten UEFA coëfficiënten .

Uitslagen vanuit gezichtspunt Nea Salamina

{| class="wikitable" style=" text-align:center; font-size:90%;"
! Seizoen
! Competitie
! Ronde
! Land
! Club
! Totaalscore
! 1e W
! 2e W
! PUC
|-
|1990/91
|Europacup II
|1R
|
|Aberdeen FC
|0-5||0-2 (T)|| 0-3 (U)
|rowspan="1"|0.0
|-
|1995
|Intertoto Cup
|Groep 7
|
|Bayer 04 Leverkusen
|0-2|| 0-2 (T)||
|rowspan="4"|0.0
|-
|
|
|Groep 7
|
|OFI Kreta
|1-2||1-2 (U)||
|-
|
|
|Groep 7
|
|FK Budućnost Podgorica
|1-1||1-1 (U)||
|-
|
|
|Groep 7 (3e)
||
|JK Tervis Pärnu
|2-0 ||2-0 (T)||
|-
|1997
|Intertoto Cup
|Groep 3
|
|AJ Auxerre
|1-10||1-10 (T)||
|rowspan="4"|0.0
|-
|
|
|Groep 3
|
|FC Lausanne-Sport
|1-4||1-4 (U)||
|-
|
|
|Groep 3
|
|Royal Antwerp FC
|0-4||0-4 (U)||
|-
|
|
|Groep 3 (4e)
|
|Ards FC
|4-1||4-1 (T)||
|-
|2000
|Intertoto Cup
|1R
|
|KS Vllaznia Shkodër
|6-2||4-1 (T)|| 2-1 (U)
|rowspan="2"|0.0
|-
|
|
|2R
|
|FK Austria Wien
|1-3||1-0 (T)|| 0-3 (U)
|}
Totaal aantal punten voor UEFA coëfficiënten: 0.0

Volleybalafdeling

Erelijst (mannen)
 Landskampioen : 1989/90, 1990/91, 1997/98, 1998/99, 1999/00, 2000/01, 2001/02, 2002/03, 2012/13
 Beker : 1982/83, 1989/90, 1991/92, 1999/00, 2000/01, 2001/02, 2002/03
 Supercup : 1998/99, 1999/00, 2000/01, 2001/02, 2002/03, 2003/04

Galerij

Bekende (ex-)spelers
 Ernestas Šetkus
 Charly Konstantinidis
 Nassir Maachi
 Andres Oper
 Martijn Roosenburg
 Dino Škvorc
 Thijs Sluijter
 Dieter Van Tornhout
 Martin Vunk
  Samuel Yeboah
 Marko Klok (Volleybal)

Externe link
 Officiële website

Nea Salamina

redpajama_set_name: RedPajamaWikipedia


On Import, update a lead's status to "open." You can then run a report on leads with a status that is NOT "open" and add them to a Flow as well!
On Complete, add your prospects to a nurture Flow, so that they get a couple of touches over the next two months. On Completion of that Flow, maybe you can add them back to your original Flow or another more targeted Flow.
On Bounce, add a Salesforce task to find the correct email address for the contact that bounced.
Managers: Set up Global Automated Actions that apply to all Flows in your organization. This feature is enabled upon request; please reach out to support@grooveapp.com to learn more!
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Share a template folder with your team with add/edit access so that you can all contribute and include your own templates within the folder for everyone to use.
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Stay tuned for the new wave of analytics features that will be available to you over the next few weeks!


text:
Q: Add an API key to QGIS I can't seem to get this (Add an API key to QGIS for QOSM layer) to work.
I need to add an API key to QGIS for OpenCycleMap. I'm trying to follow the path Web > OpenLayer plugin > OSM/Thunderforest > Set API Key as described in the linked question, but my menu does not have the "OSM/Thunderforest" option.
How do I update the OpenLayers Plugin?

redpajama_set_name: RedPajamaStackExchange


text:
Хельмут (Гельмут) Гвидо (Гуидо) Александр Хейе (; 9 августа 1895, Беккинген, Саар — 10 ноября 1970, Эстрих-Винкель) — германский военно-морской деятель, вице-адмирал кригсмарине (1.08.1944), политик ФРГ.

Биография
Сразу же после окончания школы в Берлине 1.04.1914 поступил кадетом в имперский флот.

Участник Первой мировой войны. С 10.5 по 10.08.1914 служил на бронепалубном крейсере «Виктория Луиза», затем — на линкоре «Императрица» (11.08.1914—2.01.1916, 5.03.1916—2.12.1917).

В декабре 1917 — переведён в подводный флот. За боевые отличия был награждён Железным крестом 1-го и 2-го класса.

Лейтенант с 13.7. 1916 года. После демобилизации германской армии оставлен на флоте. В марте—июне 1919 — в составе гвардейского резервного полка участвовал в боях с коммунистами.

С 21.12.1924 служил командиром миноносца G-7, с 24.09.1926 — офицер связи ВМС при командовании сухопутными войсками. С 29.09.1929 — торпедный и вахтенный офицер на крейсере «Нимфа», с 17.04.1929 — торпедный офицер на лёгком крейсере «Кёнигсберг».

1.10.1929 переведён в Морское руководство. Со 2.03.1931 — командир 1-го батальона корабельной кадрированной дивизии «Остзее». 28.09.1932 назначен командиром 4-й полуфлотилии миноносцев. С 1.10.1934 по 11.04.1939 — референт и руководитель группы в Оперативном отделе Морского руководства (с 1935 — ОКМ), одновременно с 16.03.1938 — офицер связи ВМС при Имперском министерстве авиации.

Участник Второй мировой войны. В должности командира 2-й группы военных судов участвовал в операции по захвату Дании и Норвегии.

С апреля 1939 по сентябрь 1940 был первым командиром тяжелого крейсера «Адмирал Хиппер». Командуя «Адмиралом Хиппер» капитан 1-го ранга Х. Хейе во время реализации плана по вторжению германских сил в Норвегию, возглавлял Группу 2, предназначенную для захвата порта Тронхейм в апреле 1940 года, по пути к цели, идя на выручку эсминцу «Бернд фон Арним», атаковал и уничтожил английский эсминец «Глоуворм» (который успел его таранить). Затем, атаковал береговую батарею норвежцев в Хисене, подавив её огонь. После доставки десанта в Тронхейм из-за повреждений (от «Глоуворма») ушёл в Германию.

Х. Хейе через Красный Крест направил послание британскому Адмиралтейству, в котором выразил восхищение храбростью командира и экипажа «Глоуворма», что способствовало награждению капитана (посмертно) первым в период Второй мировой войне Крестом Виктории.

Кроме «Адмирала Хиппера», в состав группы (которая должна была захватить Тронхейм) вошли эскадренные миноносцы «Пауль Якоби», «Теодор Ридель», «Бруно Хейнеман» и «Фридрих Эккольдт». На их борту находилось около 1700 военнослужащих вермахта. Затем совершил несколько плаваний в Северное море. С 5.09.1940 — начальник штаба командующего охраной «Восток», с 19.10.1940 — «Запад».

В 1941 Х. Хейе получил звание вице-адмирала, с 14.02.1941 — адмирала на Юго-Востоке, с 1.07.1941 — командования группы ВМС «Юг».

18.1.1941 награждён Рыцарским крестом Железного креста. С 15 сентября по 9 ноября 1942 исполнял обязанности адмирала Чёрного моря. С 3.12.1942 — начальник штаба Командования группы ВМС «Север», одновременно с 7.06.1943 — начальник штаба флота.

20.4.1944 Х. Хейе — адмирал малых морских боевых сил, в числе которых, мини-подлодки, боевые водолазы и т. д., возглавлял диверсионно-штурмовое соединение ВМС (адмирал диверсионно-штурмовых средств), во главе которого в конце войны провёл несколько успешных операций.

В 1944 году вице-адмирал Хельмут Хейе, командовавший соединением «К», провёл специальное совещание с руководством медицинской службы кригсмарине и ведущими специалистами в области фармакологии, остававшимися на то время в Германии. На совещании также присутствовали офицеры штаба соединения «К» и командиры его дивизионов и ряда отдельных подразделений. Вице-адмирал Х. Хейе заявил, что ввиду сложившейся на тот момент в рейхе ситуации наступила настоятельная необходимость в быстрейшем создании суперсовременного медицинского препарата, нового «чудо-оружия», который позволил бы германским солдатам и матросам переносить отрицательное воздействие стрессовых ситуаций в течение намного более длительного времени, а также дал бы им возможность действовать более уверенно и хладнокровно в любых сложных ситуациях. Адмирала активно поддержал известный диверсант Третьего рейха, любимчик фюрера штурмбанфюрер СС Отто Скорцени.

10.09.1945 был интернирован британскими войсками. 6.12.1946 — освобождён.

После окончания войны был членом группы военно-морской истории в Бремерхафене (1949—1952), советником правительства ФРГ по вопросам создания и организации новой армии. В 1953 году вступил в партию ХДС (Христианско-демократический союз) канцлера К. Аденауэра, возглавлял фракцию партии в федеральном парламенте (бундестаге) с 1953 по 1961. Затем —
военный советник Бундестага (1961—1964).

Награды
 Рыцарский крест Железного креста (1941)
 Железный крест 1 класса (15 марта 1922)
 Железный крест 2 класса (14 февраля 1918)
 Крест Фридриха Августа 2-го класса (14 февраля 1918)
 Медаль «За выслугу лет в вермахте» (1936)
 Командор Ордена Короны Италии (1937)
 Нагрудный знак подводника (20 ноября 1926)
 Медаль «В память 1 октября 1938 года» (1939)
 Медаль «В память 22 марта 1939 года» (1939)
 Пряжки к Железным крестам 1 и 2 класса (1939, 1940)
 Офицерский Крест Ордена Короны Румынии

Примечания

Ссылки

Подводники Первой мировой войны (Германия)
Моряки Первой мировой войны (Германия)
Адмиралы кригсмарине
Диверсанты
Политики Германии
Члены Христианско-демократического союза Германии
Члены бундестага Германии от Нижней Саксонии


Join Dr. Charles Nicholas Saenz for this first installment of the Borderlands of Southern Colorado lecture series, co-hosted by Pueblo Archaeological and Historical Society. Museum exhibits don't just happen. The best are based on current scholarship. Saenz consulted with the Community Museums of History Colorado as a lead scholar for the Borderlands of Southern Colorado exhibit. He recently obtained tenure at Adams State University as an associate professor of history and teaches undergraduate and graduate courses on historiography and historical methodology, world civilizations, European and Latin American history and Latino studies. He also serves as board president of the Sangre de Cristo National Heritage Area, an affiliated organization of the National Park Service that promotes the rich history and culture of Alamosa, Conejos and Costilla counties, and on the board of the San Luis Valley Historical Association.


We never underestimate the power of color. Our beautiful blue floral arrangements are sure to please. Deep blue color abounds in these carefully selected bouquets from My Bloomin Shop, and make a beautiful floral gift.


The vision for Fit2Box Fitness Studio was to create a comfortable, friendly and stress-free environment in which to train people of all fitness levels so they can accomplish their fitness goals and/or relieve stress with a fun and invigorating workout.
After opening our second personal training location it appears the vision has become reality. Besides the great workouts and results our clients enoy, we also found clients enjoy the privacy factor. We only schedule one client or couple per hour providing a "totally private studio session." This has become an important part of the Fit2Box Fitness Studio model. "It's like having a certified personal trainer or boxing / kickboxing trainer at your very own fitness studio."
We believe if you're paying for a personal trainer you should be getting a private, uninterrupted session during which time you have the trainer's full attention.
(Please click on the testimonials page to see what our clients are saying).
Our sincere belief in customer service and expertise in personal training and boxing/kickboxing create the foundation for the Fit2Box Fitness Studio concept.
I believe in Health and Fitness and the benefits it can provide, especially if done in moderation under the guidance of a professional. I also believe that training in a positive environment is necessary to accomplish one's fitness goals.
Therefore, at Fit2Box our main goal is to provide a comfortable fitness studio setting where a client can enhance his/her individual fitness level while enjoying a stress-free time in his/her day.
I am confident that I can help you achieve your fitness goals because I will be there as a trainer, workout partner and friend.
the studio in Buffalo NY (Amherst/Tonawanda): 716-771-2234.
Copyright 2004-2014 Fit2Box Fitness Studio. All Rights Reserved. Buffalo Website Design by Branded Web Design.


text:
Private Reserve White
Private Reserve Red
Discover the Jack's House Foundation
Jack and Barbara Nicklaus, in partnership with the Terlato family, expand their vision to provide world-class care to those who need it most.
You Can Get Involved!
When you purchase Jack's House wines, percentage of the net proceeds of every bottle is donated to the Jack's House Foundation.
About - Philanthropists Barbara and Jack Nicklaus
Barbara and Jack Nicklaus
Philanthropists Barbara and Jack Nicklaus
A family defined by a lifetime of success in business, in sport, in philanthropy. Jack & Barbara Nicklaus have a long standing history of giving and caring for those in need. Their passion to help children is what inspired them to create the Nicklaus Children's Health Care Foundation. Funds raised impact the lives of children and families across the country. To find out more, visit the Nicklaus Children's Health Care Foundation website.
About - The Terlato Family's History of Giving
Bill, Anthony, and John Terlato
The Terlato Family's History of Giving
The Terlato Family started out in the wine industry as retailers in 1955. Over the years, they have been involved in every facet of the business as wine distributors and importers, as well as winery owners and vineyard developers. No other company in the industry has successfully operated throughout all channels. This vertical integration and diversity of experience shaped the Terlato family's unique perspective and approach to luxury wine marketing, sales and production. With the great successes realized in their business, Terlato Wine Group and the Terlato family are proud to be able to support charitable and philanthropic giving. Over the years, donations have been made to many organizations and events, and you can find out more by visiting the Terlato Wines website.
About - Jack's House Foundation supports
Video Embed:
Jack's House Foundation supports healthcare and education efforts around the world.
2015 is the launch year for the Jack's House Foundation. We look forward to supporting healthcare and education efforts through many amazing charitable organizations in the coming years. When you purchase Jack's House wines, you too are contributing to our vision. Learn more about the organizations we are supporting this year.
About - Press
Take a look at the recent media coverage on the Jack's House brand and our founding families:
Jack's House Press Release
Jack Nicklaus awarded with Congressional Gold Medal
Barbara Nicklaus honored with the 2015 Bob Jones Award
For more information regarding the Jack's House Foundation or the wines, we welcome you to send a message.
Jack's House Wines embodies the spirit of giving. Contact us ›
"The heart of the Foundation is the people who continue to believe in and support our mission. To them, we send our heartfelt thanks."
Stay up to date on the latest news from Jack's House by joining our email list to receive our newsletter, or by following us on Twitter, Facebook and YouTube.
Copyright © 2020 Jack's House Foundation
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text:
inXile Entertainment Currently Working on 2 New RPGs
Cybertegic / October 21, 2020
American video game developer, inXile Entertainment, reveals that they are currently working on two new RPGs. The news came via a tweet posted by the Studio Head Brian Fargo.
Fargo's tweet was a response to a fan, asking if the studio has another development game since Wasteland 3 was released last August. Fargo said that they are working on two new wonderful RPGs. However, he also mentioned that it is too bad that these games take so long to make.
In a follow-up tweet, he then explained that the second of the two new RPGs that they are currently developing is still on its pre-production level. This means that the game has a long way to go.
Wasteland 3 was released last August 28 for gaming PC and consoles. It is a squad-based RPG that features turn-based combat gameplay from an isometric perspective. The game is set in a post-apocalyptic Colorado, which has turned into a freezing wasteland. The players' decisions in this game are crucial because they can impact the game's world and story. Wasteland 3 also features a primary campaign where players can play cooperatively with one of his friends online.
Aside from Wasteland, the studio has been working hard on Frostpoint VR, currently in its Open Beta on Steam and Oculus Store. Fans also hope that some of inXile Entertainment's future projects will be related to Microsoft's Bethesda acquisition. Since inXile is owned by Microsoft and Brian Fargo used to work with Bethesda's Fallout series. It may be possible that the two companies could work again on a new Fallout game.
inXile Entertainment has worked on a lot of games aside from the Wasteland series. Some of these games include Torment: Tides of Numenera, The Bard's Tale, Hunted: The Demon Forge, Line Rider 2, The Mage's Tale, and Super Stacker.
October 21, 2020 in News. Tags: gaming news, InXile Entertainment, inxile news, new rpg, new RPGs, Wasteland 3
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Background: Thrombopoietin (TPO), the major hormone controlling platelet production, and transforming growth factor-beta1 (TGF-β1), a kind of growth suppressor acting on megakaryopoiesis, have been measured in thrombocytopenias with discordant results. The aim of this study was to explore the relationship between TPO, TGF-β1 and idiopathic thrombocytopenic purpura (ITP) in children.
Methods: TPO and TGF-β1 levels in the serum and bone marrow of 45 children with ITP were measured using the enzyme-linked immunosorbent assay (ELISA) method. Twelve healthy children were enrolled as controls.
Results: The serum level of TPO was higher in ITP children than in the controls, but no significant difference was observed between them (P>0.05). The serum level of TGF-β1 was significantly higher in ITP children than in the controls (P<0.01). The serum level of TPO after therapy was lower than that before treatment, but there was no significant difference between them. Some ITP children having a poor response to steroids had a significantly higher serum TPO level than those having good response and the controls. The bone marrow level of TPO was higher in ITP children than in the controls and also higher than the serum level. There was a positive correlation between the serum level and bone marrow level of TPO (r=0.99, P<0.01). The bone marrow level of TGF-β1 was higher than the normal serum level. There was a positive relation between serum level and bone marrow level of TGF-β1 (r=0.80, P<0.01). Before treatment, ITP children had a low platelet count but a high level of TPO. After treatment, when the platelet count increased, the level of TPO reduced. There was a negative correlation between TPO and platelet count (r=-0.649, P<0.05) and between TPO and megakaryocyte count (r=-0.519, P<0.05).
Conclusions: In the pathogenesis of ITP, TGF-β1 is a feedback regulating factor. The levels of TPO and TGF-β1 in serum and bone marrow could help evaluate ITP children's conditions, estimate prognosis, and enact treatment regimens.
The injury or dysfunction of megakaryocytes will lead to thrombocytopenia.[1,2] During the maturity of megakaryocytes, cytokines play important roles. The stimulating cytokines include thrombopoietin (TPO), interleukin (IL)-3, IL-6 and IL-11,[3-8] whereas the inhibiting cytokines include transforming growth factor-beta1(TGF-β1), heparin-combined protein, polypeptide and others.[9,10] In this cytokine network which affects the maturity of megakaryocytes, TPO and TGF-β1 are the key modulating factors. Idiopathic thrombocytopenic purpura (ITP) is the most common hemorrhagic disease in children.[11,12] The aim of this study was to investigate the relationship between TPO, TGF-β1 and thrombocytopenic disease immunologically and molecule biologically for the diagnosis and treatment of ITP children.
We studied 45 children with acute ITP from January 2000 to December 2001, of whom 26 were boys and 19 girls, aged from 5 months to 12 years (mean 5.8 years). These patients were treated with prednisone at a dose of 1.5-2.0 mg/kg/d, tid, po. When their platelet count was normal, the dose was reduced gradually. The period of treatment lasted 4-6 weeks. Twelve healthy children served as controls, 7 boys and 5 girls, aged from 10 months to 11 years (mean 6.5 years).
The specimen of peripheral venous blood was taken at early morning on an empty stomach and bone marrow through sternal puncture. The levels of TPO and TGF-β1 in serum and bone marrow were assayed using the eneyme-linked immunosorbent assay (ELISA). The kits of TPO and TGF-β1 were purchased from Jingmei Biology Company, Beijing, China. The number of peripheral blood platelets and megakaryocytes in bone marrow slides were counted at the same time.
All analyses were performed using Statistical Package for the Social Science Software (SPSS, Inc., Chicago, USA). A P value of less than 0.05 was considered statistically significant.
The serum level of TPO was higher in the ITP children than in the controls, but no significant difference was noted (Table 1). The serum level of TGF-β1 was significantly higher in the ITP children than in the controls.
Compared with controls, *: P>0.05; **: P<0.01.
The serum level of TPO in ITP patients was slightly lower after therapy (23.44±6.41 μg/L) than before treatment. The serum TPO level in ITP patients with a poor response to steroids was significantly higher (35.29±3.29 μg/L) than in those with a good response (21.67±1.47 μg/L) and the controls.
After treatment, the serum TGF-β1 mass concentration (89.42±2.60 μg/L) was still significantly higher than normal or was not decreased significantly than that before treatment.
The TPO and TGF-β1 levels of serum and bone marrow in 15 ITP children and 6 controls were detected (Table 2). There was a positive correlation between serum level and bone marrow level of TPO (r=0.99, P<0.01). There was a positive relation between serum level and bone marrow level of TGF-β1 (r=0.80, P<0.01).
Compared with normal, *: P<0.01; compared with serum, #: P<0.01.
Before treatment, ITP children had a low platelet count (38±23×109/L) but a high level of TPO. After treatment, when platelet count increased (133±83×109/L, the level of TPO reduced. A negative correlation was observed between TPO and platelet count (r=-0.649, P<0.05) and between TPO and megakaryocyte count in bone marrow (r=-0.519, P=0.041). The serum TPO level was significantly higher in some children with a poor response to steroids than in those with a good response. The megakaryocyte count (131.14±120.06/slide) was lower in the former than in the latter (389.44±317.60/slide).
The level of TPO is mainly modulated by peripheral blood platelet and bone marrow megakaryocyte. This modulation depends on the intake and disruption of C-MPL, the receptor of TPO in the platelet. The intake of TPO is reduced when serum platelet count is low, then the serum level of TPO rises, thus promoting the proliferation, differentiation, maturation of megakaryocyte and the generation of platelet.[16-18] Eventually, this will result in accelerating the intake and degradation of TPO to gain a new balance as a negative feedback effect.
In the present study, we found that before treatment, ITP children had a low platelet count but a high level of TPO. After treatment, however, when the platelet count increased, the level of TPO decreased. There was a negative correlation between TPO and platelet count. The results of this study demonstrated that the number of platelets is an important factor modulating the serum level of TPO. This study also showed a negative correlation between TPO and megakaryocyte count.
TGF-β1 negatively modulates hematopoiesis. Inhibition of CFU-Meg by TGF-β1 has been previously proved by several investigators. By inhibiting the karyokinesis of megakaryocyte, TGF-β1 suppresses the maturity of megakaryocyte and generation of platelet.[21,22] Our study showed that the serum level of TGF-β1 in ITP children was significantly higher than that of controls because TGF-β1 exists in megakaryocyte and α granules of platelet, and the disruption of megakaryocyte and platelet may result in the release of TGF-β1.
Sakamaki et al discovered that TGF-β1 not only directly inhibited the formation of CFU-Meg, but also acted on megakaryocyte indirectly through modulating the TPO formation of stromal cells. Bone marrow stromal cell was affected by increased TGF-β1 and produced plentiful TPOmRNA, which was translated into TPO. Hematopoietic stem cells were affected by TPO and differentiated into megakaryocyte. TGF-β1 combined with the surface receptor of megakaryocyte to inhibit the function of megakaryocyte. A feedback modulating cycle was then formed.
The relation of steroids therapy to the levels of TPO and TGF-β1 proved that the assay of TPO is important for assessing the prognosis of ITP patient. If the result of steroids treatment is not satisfactory, other management should be adopted to avoid the repeated use of steroids and their side-effects.
Ethical approval: This study was approved by the Regional Committee on Medical Research Ethics of Jinan, China.
Contributors: JXL proposed the study and wrote the first draft of this paper. All authors contributed to the intellectual content and approved the final version.
1 Hu T, Shi XD, Feng YL, Liu R, Li JH, Chen J, et al. Comparative study on bone marrow megakaryocytes in children with thrombocytopenic purpura, aplastic anemia and myelodysplastic syndrome. Zhonghua Er Ke Za Zhi 2005;43:183-187.
2 Bruin M, Tijssen MR, Bierings M, de Haas. Juvenile cyclic amegakaryocytic thrombocytopenia: a novel entity. J Pediatr Hematol Oncol 2005;27:148-152.
3 Lefebvre P, Winter JN, Meng Y, Cohen I. Ex vivo expansion of early and late megakaryocyte progenitors. J Hematother Stem Cell Res 2000;9:913-921.
4 Wu KH, Peng CT, Li TC, Wan L, Tsai CH, Lan SJ, et al. Interleukin 4, interleukin 6 and interleukin 10 polymorphisms in children with acute and chronic immune thrombocytopenic purpura. Br J Haematol 2005;128:849-852.
5 Fishley B, Alexander WS. Thrombopoietin signalling in physiology and disease. Growth Factors 2004;22:151-155.
6 Hao J, Sun L, Huang H, Xiong G, Liu X, Qiu L, et al. Effects of recombinant human interleukin 11 on thrombocytopenia and neutropenia in irradiated rhesus monkeys. Radiat Res 2004;162:157-163.
7 Sigurjonsson OE, Gudmundsson KO, Haraldsdottir V, Rafnar T, Agnarsson BA, Gudmundsson S, et al. Flt3/Flk-2 ligand in combination with thrombopoietin decreases apoptosis in megakaryocyte development. Stem Cells Dev 2004;13:183-191.
8 Vannucchi AM, Bianchi L, Paoletti F, Pancrazzi A, Torre E, Nishikawa M, et al. A pathobiologic pathway linking thrombopoietin, GATA-1, and TGF-beta1 in the development of myelofibrosis. Blood 2005;105:3493-3501.
9 Kalina U, Koschmieder S, Hofmann WK, Wagner S, Kauschat D, Hoelzer D, et al. Transforming growth factor-beta1 interferes with thrombopoietin-induced signal transduction in megakaryoblastic and erythroleukemic cells. Exp Hematol 2001;29:602-608.
10 Lu L, Wang LS, Cooper RJ, Liu HJ, Turner K, Weich N, et al. Suppressive effects of TNF-alpha, TGF-beta1, and chemokines on megakaryocytic colony formation in CD34+ cells derived from umbilical cord blood compared with mobilized peripheral blood and bone marrow. J Hematother Stem Cell Res 2000;9:195-204.
11 Kaplan RN, Bussel JB. Differential diagnosis and management of thrombocytopenia in childhood. Pediatr Clin North Am 2004;51:1109-1140.
12 Imbach P, Kuhne T, Zimmerman S. New developments in idiopathic thrombocytopenic purpura (ITP): cooperative, prospective studies by the Intercontinental Childhood ITP Study Group. J Pediatr Hematol Oncol 2003;25(Suppl 1):S74-76.
13 Kaushansky K. Thrombopoietin: a tool for understanding thrombopoiesis. J Thromb Haemost 2003;1:1587-1592.
14 Kuter DJ, Begley CG. Recombinant human thrombopoietin: basic biology and evaluation of clinical studies. Blood 2002;100:3457-3469.
15 Mouthon MA, Van der Meeren A, Gaugle MH, Visser TP, Squiban C, Gourmelon P, et al. Thrombopoietin promotes hematopoietic recovery and survival after high dose whole body irradiation. Int J Radist Oncol Biol phys 1999;43:867-875.
16 Dame C. Thrombopoietin in thrombocytopenias of childhood. Semin Thromb Hemost 2001;27:215-228.
17 Randi ML, Putti MC, Pacquola E, Luzzatto G, Zanesco L, Fabris F. Normal thrombopoietin and its receptor (c-mpl) genes in children with essential thrombocythemia. Pediatr Blood Cancer 2005;44:47-50.
18 Scheding S, Bergmann M, Shimosaka A, Wolff P, Driessen C, Rathke G, et al. Human plasma thrombopoietin levels are regulated by binding to platelet thrombopoietin receptors in vivo. Transfusion 2002;42:321-327.
19 Ling E, Robinson DS. Transforming growth factor-beta1: its anti-inflammatory and pro-fibrotic effects. Clin Exp Allergy 2002;32:175-178.
20 Christine C, Michael A. Transforming growth factor-beta1 regulates lung epithelial barrier function and fluid transport. Am J Physiol Lung Cell Mol Physiol 2003;285:L1190-1191.
21 Sanchez-Capelo A. Dual role for TGF-beta1 in apoptosis. Cytokine Growth Factor Rev 2005;16:15-34.
22 Atabay B, Oren H, Irken G, Kizildag S, Tunali S, Turker M, et al. Role of transforming growth factor-beta1 gene polymorphisms in children idiopathic thrombocytopenic purpura. J Pediatr Hematol Oncol 2003;25:885-889.
23 Sakamaki S, Hirayama Y, Matsunaga T, Kuroda H, Kusakabe T, Akiyama T, et al. Transforming growth factor-beta1 (TGF-β1) induces thrombopoietin from bone marrow tromal cells, which stimulates the expression of TGF-β receptor on megakaryocytes and, in turn, renders them susceptible to suppression by TGF-β itself with high specificity. Blood 1999;94:1961-1970.
24 Kumar M, Vik TA, Johnson CS, Southwood ME, Croop JM. Treatment, outcome, and cost of care in children with idiopathic thrombocytopenic purpura. Am J Hematol 2005;78:181-187.


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Smith Wigglesworth (June 8, 1859 – March 12, 1947), was a British evangelist who was important in the early history of Pentecostalism.
Smith Wigglesworth was born on June 8, 1859 in Menston, Yorkshire, England, to an impoverished family. As a small child, he worked in the fields pulling turnips alongside his mother; he also worked in factories. During his childhood he was illiterate.
Nominally a Methodist, he became a born again Christian at the age of eight. His grandmother was a devout Methodist; his parents, John and Martha, were not practicing Christians although they took young Smith to Methodist and Anglican churches on regular occasions. He was confirmed by a Bishop in the Church of England, baptized by immersion in the Baptist Church and had the grounding in Bible teaching in the Plymouth Brethren while learning the plumbing trade as an apprentice from a man in the Brethren movement.
Wigglesworth married Polly Featherstone on May 2, 1882. At the time of their marriage, she was a preacher with the Salvation Army, and had come to the attention of General William Booth. They had one daughter, Alice, and four sons, Seth, Harold, Ernest and George. Polly died in 1913.
Wigglesworth worked as a plumber, but he abandoned this trade because he was too busy for it after he started preaching. In 1907 Wigglesworth visited Alexander Boddy during the Sunderland Revival, and following a laying-on of hands from Alexander's wife Mary Boddy he experienced speaking in tongues (glossolalia). He spoke at some of the Assemblies of God events, though he never joined the denomination.
Wigglesworth ministered at many churches throughout Yorkshire, often at Bethesda Church on the outskirts of Sheffield, where he claimed to have had many prophecies. He also had an international ministry: as well as Sweden, he ministered in the U.S., Australia, New Zealand, South Africa, the Pacific Islands, India, Ceylon, and several countries in Europe. Some of his sermons were transcribed for Pentecostal magazines, and these were collected into two books: Ever Increasing Faith and Faith that Prevails.
Wigglesworth is considered one of the most influential evangelists in the early history of Pentecostalism and is also credited with helping give the movement a large religious audience.
David du Plessis recounted that Wigglesworth prophesied over him that God would pour out his Spirit on the established churches, and that David du Plessis would be greatly involved in it. Later du Plessis was very much involved in the Charismatic movement.
Wigglesworth claimed that God had healed him of appendicitis and much of his ministry was focused on faith healing. There were many miracles attributed to him, some reported in the popular press and in Pentecostal magazines such as 'Confidence' which had been founded by Boddy. Wigglesworth avoided all medical treatment, despite suffering from kidney stones in his later years. These eventually passed naturally. He refused any surgical procedure, and stated that no knife would ever touch his body either in life or death. Wigglesworth was said to have raised several persons from the dead - including his wife Polly, a man called Mitchell, and a Baptist Pastor's wife, a Mrs. Clarke. His friend and biographer Walter Hibbert adds the claim of a man raised from the dead who had been embalmed and was in a funeral parlour, and Wilson in his biography tells of a woman who, brought into a meeting in a coffin, slapped Wigglesworth's face after being raised up, stating that she had had a far better time in the hereafter. Wigglesworth was said to have raised between three and twenty-three persons from the dead.
^Bickle, Michael, Smith Wigglesworth Biography.
^Frodsham, Stanley Howard. Smith Wigglesworth pp. 44-45.
^ Wigglesworth, Smith. Ever Increasing Faith.
^ Cartwright, Des. Life of Smith Wigglesworth.
Bickle, Michael. "Smith Wigglesworth Biography". Archived from the original on 2006-05-18. http://web.archive.org/web/20060518010249/http://www.mklangl.com/wigglesworthrbio.html. Retrieved 2006-05-18.
Frodsham, Stanley Howard (1948). Smith Wigglesworth: Apostle of Faith. Springfield, MO: Gospel Publishing House.
Wigglesworth, Smith (1924). Ever Increasing Faith. Springfield, MO: Gospel Publishing House. http://www.worldinvisible.com/library/wigglesworth/5f00.0930/5f00.0930.c.htm. Retrieved 2006-12-13.
Cartwright, Des. "Life of Smith Wigglesworth". http://www.smithwigglesworth.com/life.htm. Retrieved 2009-11-21.
Hibbert, Albert. (1982) Smith Wigglesworth: The Secret of His Power. Harrison House: Tulsa, Oklahoma.
Sumrall, Lester. "Yes Jesus .TV "Smith wigglesworth"". http://www.youtube.com/watch?v=iOfIV53FHWI&feature. Retrieved 2010-12-14.
Ever Increasing Faith. (PDF) 1924. Zao Ministries International.
Faith That Prevails. 1938. Biblioteca di eVangelo.
Christian Preservation Society. Wigglesworth bio.
Wind and Fire Ministries. Smith Wigglesworth, Spiritual Leader Bio. Cedar Rapids, Iowa.


Since the 1990s, manual sampling trips on Lake Champlain have gathered data on its dynamics every few weeks. But the measurements they've gleaned are sparse when you consider faster-paced changes that the lake could see in a future of predicted climate upheaval.
To help fill that gap and meet a host of other needs, scientists at the State University of New York (SUNY) — Plattsburgh have deployed a new lake data buoy on the water body. It is only the second such monitoring platform launched in Lake Champlain, after another that logs in Missisquoi Bay.
The new cellular data buoy, sitting not far from Valcour Island, is providing previously unavailable data on the lake in real time. These are helping research and education at the university, while also helping to improve National Weather Service forecasts and making things a little safer for local fishermen.
The location gives investigators a prime spot to track how its thermocline changes, which they're doing with a NexSens TS210 thermistor string. It runs from the water's surface all the way down to the sediments and is a whopping 50 meters long. Additional data on the water's temperature, pH, dissolved oxygen and conductivity are gathered by a Eureka multi-probe.
Leibensperger says that previous efforts to document Lake Champlain's thermocline only reached from the sediments to 6 meters below the surface. And the data he shared with us showed in great detail the extreme fluctuations that the lake can experience thanks to wind and an active seiche.
Those wind speed and direction measurements are gathered by an Airmar 200WX weather station that also logs data on air temperature and barometric pressure. They are proving useful in helping an ongoing investigation at the university that's looking to learn more about the dynamics of zooplankton movement.
The work has SUNY — Plattsburgh researchers going out periodically with plankton nets to sample above and below the thermocline.
In addition to those research and educational uses, measurements from the NexSens CB-450 lake data buoy are helping National Weather Service forecasters who previously didn't have enough data on air temperatures, water temperatures and wind speed to calibrate their models. The improved forecasts mean that fishermen and boaters who go out on the water don't have to wonder as much about the accuracy of weather estimates.
Measurements from the lake data buoy are available on Leibensperger's university website. The portal showcases current conditions the buoy is reporting and features graphing tools that make it possible to view historical data.
The open accessibility is a step in the right direction, as it's odd to hear that data are lacking on Lake Champlain. Despite being one of the more famous lakes in the United States, Leibensperger explains that the water body is in a tough spot.
In the future, researchers are looking to upgrade the weather sensor to also gather data on solar radiation and humidity. Knowledge of those parameters could permit the development of an energy budget for the lake.
Funding for the cellular data buoy was provided by the Lake Champlain Sea Grant and the Lake Champlain Research Consortium.


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The Dolomites are well-known for their characteristic white appearance due to high amounts of chalk within their range. Apart from the scientific, geomorphic explanation of the phenomena of those white mountains, numerous tales search for a reason, too. One of those tales is "Die bleichen Berge" a story full of passion and love. Giammi Tossi's work station are those breathtaking mountains. While constructing the slope close to Passo Falzarego he is surrounded by this miracle of nature.


When is fiber optic moving into your home?
IPTV, Video on Demand and Triple Play (TV, telephone and Internet via a single connection) increasingly bring larger amounts of data in the distribution and access networks of cities and municipalities. The fibre optic is moving closer to the buildings, and FTTH (Fibre to the Home) and FTTB (Fibre to the Building) projects keep multiplying.
Users are being provided with increasingly higher bandwidth - but it is often overlooked that the cabling used in residential buildings are often not able to cope with high data rates. Only high-quality fibre optic cables, connection sockets and distribution components ensure that the connected terminal devices can fully receive the capacity being made available "from outside".
Telegärtner offers a fast and easy to install Fibre-In-The-Home system especially for retrofitting or upgrading of a fibre optic cabling in houses, apartments and residential units. This includes preconfigured LWL connection socket and LWL wall and patch panel.
Thanks to the preconfigured FIFTH OAD/S connection sockets installers can perform the installation quickly and do not have to remain the residential unit for long. Expensive splice and measuring instruments are not necessary for using the FIFTH OAD/S connection sockets.


text:
Architecture of the Tool
Funding and Acknowledgements
Knowledge Synthesis Methods
Krystle Amog
Ba' Pham
Megan Mak
Andrew Booth
Christina Godfrey
Sharon Straus
Andrea C. Tricco
Navjot Mann
Katrina Chiu
Andrea Jimenez
Dr. Andrea C. Tricco (PhD, MSc) is a Scientist and Director of the Knowledge Synthesis Team in the Knowledge Translation Program of the Li Ka Shing Knowledge Institute, St. Michael's Hospital. She is an Associate Professor at the University of Toronto in the Dalla Lana School of Public Health & Institute of Health Policy, Management, and Evaluation. She is also a Co-Director & Adjunct Associate Professor for the Queen's Collaboration for Health Care Quality Joanna Briggs Institute (JBI) Centre of Excellence at Queen's University.
Dr. Tricco is a knowledge synthesis methodologist with >270 publications in this area, including papers in high-impact journals (e.g., British Medical Journal , Journal of the American Medical Association, Lancet). She currently holds a Tier 2 Canada Research Chair in Knowledge Synthesis. She has been commissioned by several agencies to conduct knowledge synthesis, such as the World Health Organization and Ontario Ministry of Health and Long-term Care. Her research has been covered by major media outlets, such as CTV News, Global News, and Radio Canada International. She has presented at >190 local, national, and international meetings and led >60 reports for decision-making agencies. She is also an Associate Editor for the Journal of Clinical Epidemiology, and Systematic Reviews; and sits on the Editorial Board for BMC Medicine and JBI Evidence Synthesis. She developed and teaches an online systematic review course that >560 students have completed.
Ba' Pham (PhD, MSc) is a research associate, health economist, decision modeler, systematic review methodologist, and biostatistician. Ba' took early retirement from the Toronto Health Economics and Technology Assessment Collaborative in July 2015 and is working as a casual employee for the Knowledge Translation Program.
Krystle Amog (HBSc, MSc(c)) is the project lead for the Right Review tool and a research assistant for the Knowledge Translation Program. She holds an Honours Bachelor of Science from the University of Toronto and is currently completing a Master's degree in Health Services Research at the Institute of Health Policy, Management, and Evaluation at the University of Toronto. Her thesis work is focused on understanding the lived experience of socially frail older adults, which was recently recognized by an AGE-WELL NCE graduate award. Krystle's research interests are in the fields of aging and knowledge translation with an emphasis on investigating how technology can be applied and integrated to optimize health services for older adults.
Katrina Chiu is a graduate from the University of Toronto and a former Research Assistant on the Knowledge Synthesis team at the KTP. She has a wide range of professional experience in health research and community health, with a focus on evidence-informed decision making and health equity. Katrina currently works as an Implementation Associate at Maple, managing the implementation and evaluation of public sector partnerships to make telehealth accessible for all Canadians.
Navjot Mann (HBSc) is a research assistant II for the Knowledge Translation Program. She holds an Honors Bachelor of Science with an Interdisciplinary minor in Sustainability from McMaster University. Navjot has gained relevant research experience at McMaster Children's Hospital and Brampton Civic Hospital while working as a research assistant in the Paediatric Departments. Navjot currently supports various research projects conducted within the Knowledge Translation Program at the Li Ka Shing Knowledge Institute.
Megan Mak is a web developer for the Knowledge Translation Program. She is a self-taught web developer that focuses on building and maintaining PHP-based web tools. She is the head web developer for several projects for the program, such as the Systematic Prospective Assessment of Rapid Knowledge Synthesis (SPARKS) study and the Right Review tool.
Andrea Jimenez is a Web Developer for the Knowledge Translation Program of the Li Ka Shing Knowledge Institute, St. Michael's. She has worked at St. Michael's Hospital since 2011, her focus is in front-end development and thrives on turning complex ideas into alluring interface designs with effortless user experiences.
Melissa Courvoisier
Melissa Courvoisier (MEd, BA) has a background in adult education and is particularly interested in using critical pedagogy to design, deliver, and evaluate inclusive and innovative in-person and online training interventions that build capacity at the individual, organizational, and systems level.
Andrew Booth is Professor in Evidence Synthesis at the School of Health and Related Research (ScHARR) at the University of Sheffield, UK and a co-Convenor of the Cochrane Qualitative and Implementation Methods Group. He holds honorary contracts with the World Health Organisation and with the UK Office for Health Improvement and Disparities and is an Honorary Research Associate of Evidence Synthesis Ireland/Cochrane Ireland. A health information specialist by background, Andrew has been a review methodologist for almost 30 years. Over the last five years he has been the world's most prolific author of methodology/examples of qualitative evidence synthesis. Professor Booth has published over 230 peer-reviewed articles, 89 book chapters and six books. His article on 14 different review types has been cited almost 6050 times. With colleagues he has recently published the 3rd edition of Systematic Approaches to a Successful Literature Review (Sage, 2021). He teaches on two Masters level review modules and on external short courses in qualitative evidence synthesis, systematic reviews, mixed methods reviews and rapid reviews. He has delivered review training to the National Institute for Health and Care Excellence (NICE), Public Health England, the Health Safety Executive and the US Agency for Healthcare Research and Quality.
Dr. Christina Godfrey is an Associate Professor in the Queen's University School of Nursing and is the Co-Director/ Methodologist for Queen's Collaboration for Health Care Quality: A JBI Centre of Excellence. As a specialist in research synthesis methodologies Dr. Godfrey has received formal synthesis training through the Cochrane Collaboration and Joanna Briggs Institute (JBI), and is a certified trainer in the JBI method of evidence synthesis. In her role as Co-Director/ Methodologist Dr. Godfrey spearheads the leadership and advancement of synthesis methodologies and knowledge translation, providing methodological support to faculty, clinicians, and graduate students internal to Queen's University and to other Centres in Canada and Africa. Dr. Godfrey sits on four international methodology committees focused on advancing the methodology of evidence synthesis and knowledge translation.
Sharon Straus (MD, FRCPC, MSc) is a geriatrician and clinical epidemiologist who trained at the University of Toronto and the University of Oxford. She is the Director of the Knowledge Translation Program and Interim Physician-in-Chief, St. Michael's Hospital; Director, Division of Geriatric Medicine, University of Toronto; Vice Chair, and Professor, Department of Medicine, University of Toronto. She holds a Tier 1 Canada Research Chair in Knowledge Translation and Quality of Care and has authored more than 400 publications and 3 textbooks in evidence-based medicine, knowledge translation and mentorship. She is in the top 1% of highly cited clinical researchers as per Web of Science. She holds more than $57 million in peer reviewed research grants as a principal investigator. She has received national awards for mentorship, research and education.
© Knowledge Translation Program 2023 ( Login )


Microsoft's official entry into the consumer networking hardware business has been met with mixed reactions from industry watchers. Some say the line of wired and 802.11b wireless routers and network adapters is priced right, and has the advantage of Microsoft's Support organization behind it. Others say it's a ho-hum offering, with little to differentiate it from the slew of established products from Linksys, SMC, D-Link, NETGEAR, and others.


text:
Loblaw Tests Click And Collect Drive-Thru
Loblaws announced earlier this year that it would pilot a click-and-collect program, but a company spokesman did confirm that Richmond Hill will be the first location to offer the new service.
Loblaw Companies Ltd. is preparing to pilot a grocery click-and-collect program, which will allow shoppers to order online and pick up their completed order at stores, according to The Toronto Star.
The Loblaws at 301 High Tech Rd. in Richmond Hill has been set up with a bright orange click-and-collect area that includes assigned parking. Customers will be able to have the groceries they chose and pay for online, loaded into their vehicles.
Loblaws announced earlier this year that it would pilot a click-and-collect program, but provided few details. A company spokesman declined to elaborate on Tuesday, although he did confirm that Richmond Hill will be the first location to offer the new service.
"The service is not yet available to the public, but we're excited by the prospect of offering busy customers another option to complete their shopping, saving considerable time in the process," said Loblaw spokesperson Kevin Groh.
Walmart Expands Click And Collect To Eight Cities
Peapod To Test D.C. Metro Station Pickup Points
Dash's Market To Offer Click-And-Collect, Curbside Pickup
Woolworths Posts Online Grocery Sales Boom In Australia


In three years, and with three hundred employees...Oh Mi Gawd!
First off, a very happy new year, sweeties. May your furniture have more bugs than the OS in your gadgets and so on, if you know what I mean.
You know, darlings, in spite of what you might all think of me, Aunty does not really know everything.
I do not, for example, know why those darlings at Apple could not have told us from the very beginning that they would slow down those iPhones when batteries got old and temperatures got low (dearies, even I get slow when the temperature goes low – oh my aching knees).
I also do not know why companies have so many dates for different activities – this date for unboxing, that day for comparisons, that day for photographs, that day for reviews, that day for bathing…whatever, honeybear, whatever.
And while we are on the subject, I do not know why Bangladesh has got the Mate 10 Pro while we in Mera India are making do with the Honor V10, in spite of all those statements about India being a huge smartphone market.
But one thing I DEFINITELY know – Xiaomi is the number one when it comes to smartphones in India, honey dolls. Not only that, they are the first company to become number one in India in smartphones in three years. And with less than three hundred employees at that. Amazing. And all thanks to their amazing fans, who have always supported the brand (such fan base, dearies).
That Manu Jain. So handsome. So charismatic. So modest. So unassuming. And now, so much on social media. And now also so often reminding us that Xiaomi is number one.
Of course, he is right to feel pride in his achievement. I mean come on, darlings, it took them three years with a team of about three hundred (and that is now, sweethearts. When they started out, that Nimish told me they had barely 3-5 people in the team and one of them was that handsome Hugo – what is it with these guys and handsomes?) to beat the likes of Samsung, Sony, Nokia, HTC, LG, Motorola and even apna Micromax and Intex and all. Oh, and all those amazing fans, sweethearts. And it is not as if they have zero competition or everything they have touched turned into gold – you know the Mi 5, and Mi 4 did not do AS well as they expected and then that handsome Hugo left last year, and then new companies kept coming into the Indian market (everyone loves our almost 1 billion consumers, honeydoll), brands like Vivo, Oppo and OnePlus (it is part of Oppo and not part of Oppo, such diversity, babes) and of course Lenovo also became stronger. Anyway to cut a long saga short, what Xiaomi has achieved is nothing short of a miracle. That Manu Jain fully deserves to be on the cover of Forbes (no, I refuse to believe his PR fixed that story – there are intelligent people at the magazine too, sweethearts) and actually, I would put him on the cover of most publications out there.
2017 was Xiaomi's year in India. How many companies can make it to the top of the smartphone market in just three years and with barely three hundred employees, sweethearts? Oh, and those amazing fans, without whom this would not have been possible. It is amazing what they have done, and they started out online only also, and then everyone said that being only on the Internet would not work so they this year started going to normal shops, like you know, the mobile phone shop Pappu darling has at the corner, and you know, even there they have been selling phones. Amazing, no?
See? I know so much about the company. Such is the power of social networks and constant reminders, darlings.
You know what I mean, darlings.
The Huawei P20 is Coming to India, Darlings?
Is Apple Saying Goodbye to the Notch Already, Darlings?


text:
Reporting on our health services: NUJ masterclass
Kate Griffin, NUJ Oxford & district branch
Which hospital could be the next Mid-Staffs, the scandal-hit NHS foundation trust where 1, 200 patients needlessly died?
It was Shaun Linten, as a reporter for the local Express & Star, who broke the story that led to a huge public inquiry and the Francis report, led by Robert Francis QC, which was published this February.
His concern is that because of cuts to local newspapers – he has not been replaced since he left his paper – and the reduction in health specialists on national titles and broadcasting, such stories could remain uncovered. Getting the data and the inside information of a hospital takes considerable legwork.
"How many health reporters have the time to read all the documentation and get out of the office to interview people, when they are also covering church fetes as well? We need to have some editorial leadership in newsrooms if health journalism is to continue to survive."
Shaun, who now works for the Health Service Journal, describes himself as an accidental health reporter; but now, he says, it is his passion.
Shaun was taking part in an NUJ masterclass on reporting the NHS with a distinguished panel of experts, chaired by John Lister, senior lecturer in health journalism at Coventry University, with Branwen Jeffreys, BBC health correspondent, and Paul Bradshaw, a senior lecturer in online journalism at Birmingham University, who runs a blog/project Help Me Investigate.
The audience heard that the huge reorganisation of the NHS, a "dreadful" new Department of Health website, added to the cuts to health journalism have created a perfect storm.
John Lister outlined the consequences of the roll-out of the Health & Social Care Act that wound up Primary Care Trusts and Strategic Health Authorities. New bodies, Clinical Commissioning Groups (CCGs) which hold budgets at local level and a national NHS Commissioning Board, with a network of regional offices – have taken their place.
Other organisations, such as Health Watch, the so-called consumer champion for health and social care, Health & Wellbeing Boards, and council Health Oversight & Scrutiny Committees also join this transformed landscape.
One of the major problems, said Branwen Jeffreys, is that the reorganisation makes it more difficult to compare like with like, for example, comparing how institutions deal with infections, because the data will be collected in a different way and cover different areas. She was also concerned that one useful source for health journalists – GPs – are now part of the formal structure and their constitutions include gagging clauses.
She said Health Watch may be the joker in the pack, because it includes local councillors who may be prepared to speak out.
She said that there are stories to cover. With NHS spending flat-lining for the first time in many years, there will be cuts, closures, increases to waiting lists and rationing of services. The public may not get to grips with the new structure, but they will notice what is happening to their services.
Her tip was to keep an eye on underspends. In 2011/12, there was an underspend of £820 million, which all goes back to the Treasury.
Paul Bradshaw said there was a rich environment of people writing about health, including a new breed of bloggers such as Richard Grimes, and a number of campaign groups such as Save Our NHS. Although these groups are partisan, it is the job of the journalist to marry the data, the personal stories, information and opinions into a story that matters.
The story of the children's heart surgery unit at Leeds was a classic example of where it is difficult to get to the real story when the data is not always available and emotions are running high, he said.
Hospital and hospital department closures are always emotive, said Branwen Jeffreys, but it is important not to get caught up in these emotions and get to the facts: it may make sense to have to travel a little further to an Accidents & Emergency unit if the service is better.
The bad news, said Shaun Lintern, is that the reorganisation is unlikely to be the last. He predicted that many CCGs would be forced to merge because they are not sustainable. And with an election not too far away, what else do the political parties have in store? His advice to the journalists at the meeting was: read everything and talk to everybody. "This is not a job," he said. "it's a vocation."
Listen to audio clips from the event:
Transcripts of the speeches are available on the European health journalism website.
Tags: , new media, NHS, newspapers, health journalism
Companies House changes let rogue directors off the hook
NUJ statement on police investigations of the Darroch cables leak
NUJ Women Photographers, 2019
TUC LGBT+ workers conference, 2019
Pride organisers reverse decision on media access to parade following NUJ discussions
Request took 716ms


text:
using System.Text.Json;
using Azure.Core;

namespace Azure.ResourceManager.ResourceMover.Models
{
    public partial class MoverResourceSetProperties : IUtf8JsonSerializable
    {
        void IUtf8JsonSerializable.Write(Utf8JsonWriter writer)
        {
            writer.WriteStartObject();
            writer.WritePropertyName("sourceRegion");
            writer.WriteStringValue(SourceRegion);
            writer.WritePropertyName("targetRegion");
            writer.WriteStringValue(TargetRegion);
            writer.WriteEndObject();
        }

        internal static MoverResourceSetProperties DeserializeMoverResourceSetProperties(JsonElement element)
        {
            AzureLocation sourceRegion = default;
            AzureLocation targetRegion = default;
            Optional<MoverProvisioningState> provisioningState = default;
            Optional<MoveCollectionPropertiesErrors> errors = default;
            foreach (var property in element.EnumerateObject())
            {
                if (property.NameEquals("sourceRegion"))
                {
                    sourceRegion = new AzureLocation(property.Value.GetString());
                    continue;
                }
                if (property.NameEquals("targetRegion"))
                {
                    targetRegion = new AzureLocation(property.Value.GetString());
                    continue;
                }
                if (property.NameEquals("provisioningState"))
                {
                    if (property.Value.ValueKind == JsonValueKind.Null)
                    {
                        property.ThrowNonNullablePropertyIsNull();
                        continue;
                    }
                    provisioningState = new MoverProvisioningState(property.Value.GetString());
                    continue;
                }
                if (property.NameEquals("errors"))
                {
                    if (property.Value.ValueKind == JsonValueKind.Null)
                    {
                        errors = null;
                        continue;
                    }
                    errors = MoveCollectionPropertiesErrors.DeserializeMoveCollectionPropertiesErrors(property.Value);
                    continue;
                }
            }
            return new MoverResourceSetProperties(sourceRegion, targetRegion, Optional.ToNullable(provisioningState), errors.Value);
        }
    }
}

redpajama_set_name: RedPajamaGithub


The city of Kabul (and Afghanistan in general) is still pretty high on my list of places i want to visit. Unfortunately, the closest place to Kabul that i got to so far is Delhi. Fortunately, however, there is the fabulous internet where Safi Airways 'the international airline of Afghanistan' is publishing PDF versions of it's fabulous in-flight magazine. Browsing through the three available issues only reinforces my desire to go and visit the place.
Karimi Supermarket […] make sure to head upstairs for some great stuff that's fallen off some PX trucks.
… a left at the next traffic circle. slow down, the first gate to the right used to have a red chili pepper hanging up on a pole. Not easy to find.
… head down the barricaded street to almost the end. You'll see big misspelled banners showing you the way.
Update (6 sept): Spiegel online has an interview (in German) with the editor in chief off the in-flight magazine. turns out that the whole thing is intended to be 'honest' (as opposed to all other in flight magazines out there).


text:
Q: Swing: Custom JSpinner Model causes StackOverflowError I want to write myself an AbstractSpinnerModel for a JSpinner that displays values of my custom-made class Time. I've extended JSpinner, which looks like this:
TimeSpinner.java
import javax.swing.AbstractSpinnerModel;
import javax.swing.JSpinner;

public class TimeSpinner extends JSpinner {

    public TimeSpinner() {
        super();
        setModel(new TimeSpinnerModel());
        ((JSpinner.DefaultEditor) getEditor()).getTextField().setEditable(true);
    }

    public class TimeSpinnerModel extends AbstractSpinnerModel {

        private Time t = new Time(0);

        @Override
        public Object getValue() {
            return t;
        }

        @Override
        public void setValue(Object o) {
            try {
                t = Time.parseTime(o.toString());
                fireStateChanged();
            } catch (NumberFormatException e) {}
        }

        @Override
        public Object getNextValue() {
            // next 10 seconds step
            return new Time(((t.getSeconds() + 10) / 10) * 10);
        }

        @Override
        public Object getPreviousValue() {
            if (t.getSeconds() > 0) {
                // previous 10 seconds step
                return new Time(((t.getSeconds() - 1) / 10) * 10);
            }
            return t;
        }
    }
}

When I run the code, I get a StackOverflowError because there seems to be a loop of Listeners notifying each other. But in all code samples I looked through it was done exactly the way I did it, i.e. calling fireStateChanged() in setValue. Why does this happen?
My stack trace (up to the point where it starts repeating):
Exception in thread "main" java.lang.StackOverflowError
    at sun.awt.SunHints$Value.hashCode(SunHints.java:163)
    at java.awt.font.FontRenderContext.hashCode(FontRenderContext.java:352)
    at sun.font.FontDesignMetrics$MetricsKey.init(FontDesignMetrics.java:217)
    at sun.font.FontDesignMetrics.getMetrics(FontDesignMetrics.java:286)
    at sun.swing.SwingUtilities2.getFontMetrics(SwingUtilities2.java:1113)
    at javax.swing.JComponent.getFontMetrics(JComponent.java:1626)
    at javax.swing.text.PlainView.calculateLongestLine(PlainView.java:639)
    at javax.swing.text.PlainView.updateDamage(PlainView.java:574)
    at javax.swing.text.PlainView.removeUpdate(PlainView.java:464)
    at javax.swing.text.FieldView.removeUpdate(FieldView.java:307)
    at javax.swing.plaf.basic.BasicTextUI$RootView.removeUpdate(BasicTextUI.java:1624)
    at javax.swing.plaf.basic.BasicTextUI$UpdateHandler.removeUpdate(BasicTextUI.java:1884)
    at javax.swing.text.AbstractDocument.fireRemoveUpdate(AbstractDocument.java:259)
    at javax.swing.text.AbstractDocument.handleRemove(AbstractDocument.java:622)
    at javax.swing.text.AbstractDocument.remove(AbstractDocument.java:590)
    at javax.swing.text.AbstractDocument.replace(AbstractDocument.java:666)
    at javax.swing.text.JTextComponent.setText(JTextComponent.java:1669)
    at javax.swing.JFormattedTextField$AbstractFormatter.install(JFormattedTextField.java:948)
    at javax.swing.text.DefaultFormatter.install(DefaultFormatter.java:125)
    at javax.swing.JFormattedTextField.setFormatter(JFormattedTextField.java:464)
    at javax.swing.JFormattedTextField.setValue(JFormattedTextField.java:788)
    at javax.swing.JFormattedTextField.setValue(JFormattedTextField.java:501)
    at javax.swing.JSpinner$DefaultEditor.stateChanged(JSpinner.java:717)
    at javax.swing.JSpinner.fireStateChanged(JSpinner.java:458)
    at javax.swing.JSpinner$ModelListener.stateChanged(JSpinner.java:386)
    at javax.swing.AbstractSpinnerModel.fireStateChanged(AbstractSpinnerModel.java:119)
    at TimeSpinner$TimeSpinnerModel.setValue(TimeSpinner.java:26)
    at javax.swing.JSpinner.setValue(JSpinner.java:354)
    at javax.swing.JSpinner$DefaultEditor.propertyChange(JSpinner.java:752)
    at java.beans.PropertyChangeSupport.fire(PropertyChangeSupport.java:335)
    at java.beans.PropertyChangeSupport.firePropertyChange(PropertyChangeSupport.java:327)
    at java.beans.PropertyChangeSupport.firePropertyChange(PropertyChangeSupport.java:263)
    at java.awt.Component.firePropertyChange(Component.java:8430)
    at javax.swing.JFormattedTextField.setValue(JFormattedTextField.java:798)
    at javax.swing.JFormattedTextField.setValue(JFormattedTextField.java:501)
    at javax.swing.JSpinner$DefaultEditor.stateChanged(JSpinner.java:717)
    at javax.swing.JSpinner.fireStateChanged(JSpinner.java:458)

EDIT:
Here is my Time.java:
public class Time {

    private int sec;

    public Time() {
        sec = 0;
    }

    public Time(int sec) {
        this.sec = sec;
    }

    public void add(int sec) {
        this.sec += sec;
    }

    public void add(Time other) {
        this.sec += other.sec;
    }

    public int getSeconds() {
        return this.sec;
    }

    @Override
    public String toString() {
        if (this.sec < 3600)
            return String.format("%d:%02d", sec/60, sec%60);
        return String.format("%d:%02d:%02d", sec/3600, (sec%3600)/60, sec%60);
    }

    public static Time parseTime(String str) throws NumberFormatException {
        try {
            int i = Integer.parseInt(str);
            return new Time(i);
        } catch (NumberFormatException e) {}

        try {
            double d = Double.parseDouble(str.replace(',', '.'));
            return new Time((int)(d * 60.0));
        } catch (NumberFormatException e) {}

        String[] strs = str.split(":");
        int l = strs.length;
        int h, m, s;
        if (l == 3) {
            h = Integer.parseInt(strs[0]);
            m = Integer.parseInt(strs[1]);
            s = Integer.parseInt(strs[2]);
        }
        else if (l == 2) {
            h = 0;
            m = Integer.parseInt(strs[0]);
            s = Integer.parseInt(strs[1]);
        } else {
            throw new NumberFormatException();
        }

        return new Time(3600 * h + 60 * m + s);
    }
}

A: Here's your working code after some modification
TimeSpinnerModel Class
package com.test;

import javax.swing.AbstractSpinnerModel;
import javax.swing.JSpinner;

public class TimeSpinner extends JSpinner {

    public TimeSpinner() {
        super();
        setModel(new TimeSpinnerModel());
        ((JSpinner.DefaultEditor) getEditor()).getTextField().setEditable(true);
    }

    public class TimeSpinnerModel extends AbstractSpinnerModel {

        private Time t = new Time(0);

        @Override
        public Object getValue() {
            return t;
        }

        @Override
        public void setValue(Object o) {
            try {
                t.set(Time.parseTime(o.toString()));
                fireStateChanged();
            } catch (NumberFormatException e) {}
        }

        @Override
        public Object getNextValue() {
            // next 10 seconds step
            return new Time(((t.getSeconds() + 10) / 10) * 10);
        }

        @Override
        public Object getPreviousValue() {
            if (t.getSeconds() > 0) {
                // previous 10 seconds step
                return new Time(((t.getSeconds() - 1) / 10) * 10);
            }
            return t;
        }
    }
}

Time Class
public class Time {

    private int sec;

    public Time() {
        sec = 0;
    }

    public Time(int sec) {
        System.out.println(Com.cnt.getAndIncrement());
        this.sec = sec;
    }
    public void set(int sec){
        this.sec = sec;
    }
    public void add(int sec) {
        this.sec += sec;
    }

    public void add(Time other) {
        this.sec += other.sec;
    }

    public int getSeconds() {
        return this.sec;
    }

    @Override
    public String toString() {
        if (this.sec < 3600)
            return String.format("%d:%02d", sec / 60, sec % 60);
        return String.format("%d:%02d:%02d", sec / 3600, (sec % 3600) / 60,
                sec % 60);
    }

    public static int parseTime(String str) throws NumberFormatException {

        try {
            String[] strs = str.split(":");
            if (strs.length == 1) {
                return Integer.parseInt(str);

            } else if (strs.length == 2) {
                return Integer.parseInt(strs[0]) * 60
                        + Integer.parseInt(strs[1]);
            } else {

                int h, m, s;

                h = Integer.parseInt(strs[0]);
                m = Integer.parseInt(strs[1]);
                s = Integer.parseInt(strs[2]);
                return 3600 * h + 60 * m + s;
            }

        } catch (NumberFormatException e) {
            throw e;
        }
    }
}

When you create new instance of Time, number of instance goes beyond limits and cause StackOverflowError.
Other way:
As mentioned by sergiy-medvynskyy,
You can override equals and hashCode to Time class and generate state change event only if the value is really changed (if old time is equals to the new - then no change state).
Example code:
@Override
public int hashCode() {
    final int prime = 31;
    int result = 1;
    result = prime * result + sec;
    return result;
}

@Override
public boolean equals(Object obj) {
    if (this == obj) {
        return true;
    }
    if (obj == null) {
        return false;
    }
    if (!(obj instanceof Time)) {
        return false;
    }
    Time other = (Time) obj;
    if (sec != other.sec) {
        return false;
    }
    return true;
}


The real interest for me is the way an artist passing through life the way an ant crosses a sidewalk, determined that the edge exists without knowing exactly where. The artist's harvest is those special energies that bring him to life as an artist; sustain him in lonely times; shelter him in times of recognition, when he most needs protection; provide regeneration when he senses loss of power, and help drive him across failures large or small.
"This show of works made between the mid-forties and mid-eighties...is largely, often exuberantly, abstract, even when it involves recognizable subjects. Other images are more expressionist: liquid light-show eruptions and cascading patterns in acid colors."
From a review of an exhibition of Henry Holmes Smith's images at the Gitterman Gallery, New York City.
No one more than you, Henry, has worked more passionately and as well for meaning in photographs--and for possibilities. To know that you were there, looking relishing, analyzing, speculating, expounding, and yes, that too--making your images--has given me much pleasure and considerable courage these past twenty years.
I like these images as art and ornamental sense of an idea.
For me Henry was, and continues to be, a walking "mind-bomb" and I, always, a possible detonator. On occasions too numerous to mention, a passing comment would serve as a spark for an amazing explosion of ideas and possibilities. This phenomenon has continued over the many years of our friendship.


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