text:
Cloning, MolecularSequence Analysis, DNA
Tandem Repeat SequencesRepetitive Sequences, Nucleic AcidBase SequenceMinisatellite RepeatsTrinucleotide RepeatsInverted Repeat SequencesRepetitive Sequences, Amino AcidMicrosatellite RepeatsAmino Acid SequenceTrinucleotide Repeat ExpansionDinucleotide Repeats
Molecular Sequence DataBase SequenceAmino Acid Sequence
(1/1277) High sequence turnover in the regulatory regions of the developmental gene hunchback in insects.
Extensive sequence analysis of the developmental gene hunchback and its 5' and 3' regulatory regions in Drosophila melanogaster, Drosophila virilis, Musca domestica, and Tribolium castaneum, using a variety of computer algorithms, reveals regions of high sequence simplicity probably generated by slippage-like mechanisms of turnover. No regions are entirely refractory to the action of slippage, although the density and composition of simple sequence motifs varies from region to region. Interestingly, the 5' and 3' flanking regions share short repetitive motifs despite their separation by the gene itself, and the motifs are different in composition from those in the exons and introns. Furthermore, there are high levels of conservation of motifs in equivalent orthologous regions. Detailed sequence analysis of the P2 promoter and DNA footprinting assays reveal that the number, orientation, sequence, spacing, and protein-binding affinities of the BICOID-binding sites varies between species and that the 'P2' promoter, the nanos response element in the 3' untranslated region, and several conserved boxes of sequence in the gene (e.g., the two zinc-finger regions) are surrounded by cryptically-simple-sequence DNA. We argue that high sequence turnover and genetic redundancy permit both the general maintenance of promoter functions through the establishment of coevolutionary (compensatory) changes in cis- and trans-acting genetic elements and, at the same time, the possibility of subtle changes in the regulation of hunchback in the different species. (+info)
(2/1277) Tandem amino acid repeats from Trypanosoma cruzi shed antigens increase the half-life of proteins in blood.
Proteins containing amino acid repeats are widespread among protozoan parasites. It has been suggested that these repetitive structures act as immunomodulators, but other functional aspects may be of primary importance. We have recently suggested that tandem repeats present in Trypanosoma cruzi trans-sialidase stabilize the catalytic activity in blood. Because the parasite releases trans-sialidase, this delayed clearance of the enzyme might have implications in vivo. In the present work, the ability of repetitive units from different T. cruzi molecules in stabilizing trans-sialidase activity in blood was evaluated. It is shown that repeats present on T. cruzi shed proteins (antigens 13 and Shed-Acute-Phase-Antigen [SAPA]) increase trans-sialidase half-life in blood from 7 to almost 35 hours. Conversely, those repeats present in intracellular T. cruzi proteins only increase the enzyme half-life in blood up to 15 hours. Despite these results, comparative analysis of structural and catalytic properties of both groups of chimeric enzymes show no substantial differences. Interestingly, antigens 13 and SAPA also increase the persistence in blood of chimeric glutathione S-transferases, thus suggesting that this effect is inherent to these repeats and independent of the carrier protein. Although the molecular basis of this phenomenon is still uncertain, its biotechnological potential can be envisaged. (+info)
(3/1277) Cooperation between SMAD and NF-kappaB in growth factor regulated type VII collagen gene expression.
We have previously demonstrated that transforming growth factor-beta (TGF-beta) and pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) or interleukin-1beta, synergistically enhance the expression of type VII collagen gene (COL7A1) in human dermal fibroblasts in culture (Mauviel et al., 1994). Recently, we identified a SMAD-containing complex, rapidly induced by TGF-beta and binding the region [-496/-444] of the COL7A1 promoter, responsible for COL7A1 gene transactivation (Vindevoghel et al., 1998a). In this report, we demonstrate that TGF-beta and TNF-alpha response elements are distinct entities within the COL7A1 promoter. In particular, we demonstrate that the TNF-alpha effect is mediated by NF-kappaB1/RelA (p50/p65) and RelA/RelA (p65/p65) NF-kappaB complexes binding the TNF-alpha response element (TaRE) located in the region [-252/-230], with RelA acting as the transcriptional activator. Finally, we provide definitive evidence for the role of both TGF-beta and TNF-alpha response elements as enhancer sequences, functioning in the context of a heterologous promoter in an additive manner in response to TGF-beta and TNF-alpha. This study provides the first identification of a functional interaction between the two immediate-early transcription factors, SMAD and NF-kappaB, to activate the expression of an extracellular matrix-related gene, COL7A1. (+info)
(4/1277) Target joining of duplicated insertion sequence IS21 is assisted by IstB protein in vitro.
Tandemly repeated insertion sequence IS21, located on a suicide plasmid, promoted replicon fusion with bacteriophage lambda in vitro in the presence of ATP. This reaction was catalyzed in a cell extract containing the 45-kDa IstA protein (cointegrase) and the 30-kDa IstB helper protein of IS21 after both proteins had been overproduced in Escherichia coli. Without IstB, replicon fusion was inefficient and did not produce the 4-bp target duplications typical of IS21. (+info)
(5/1277) Recognition of multiple patterns of DNA sites by Drosophila homeodomain protein Bicoid.
Our previous studies demonstrated that the Drosophila homeodomain protein, Bicoid (Bcd), binds DNA cooperatively. In this study, we determined the patterns of adjacent DNA sites required for cooperative recognition by Bcd. Our in vitro selection and biochemical experiments demonstrated that Bcd binds preferentially to both head-to-head and tail-to-tail symmetric sites that are separated by short spacing. An increase in the spacing reduces the strict requirement of symmetric patterns of adjacent sites, permitting Bcd to recognize tandem repeat sites cooperatively. Our further experiments in vivo showed that the only pair of optimally spaced symmetric Bcd sites in a hunchback (hb) enhancer element contributes the most to transcriptional activation by Bcd, demonstrating the biological importance of the binding site patterns revealed by our in vitro selection studies. (+info)
(6/1277) Structure and function of the prDNA and the genomic termini of the gamma2-herpesvirus bovine herpesvirus type 4.
The linear virion DNA of bovine herpesvirus type 4 (BHV-4) is flanked by tandem repeats designated polyrepetitive DNA (prDNA). To investigate the structure and functional role of the prDNA for cleavage/packaging of progeny viral DNA, the complete nucleotide sequence (2267 bp) of a cloned prDNA unit of BHV-4 was determined. Moreover, the terminal fragments of the genome and the junctions between prDNA and the central unique DNA were analysed. In order to characterize the function of the prDNA of BHV-4, a transient packaging assay was developed. The prDNA has a G+C content of 71.1%. Its structure is composed of numerous internal repeats and every unit contains the conserved sequence of the cleavage/packaging signal. A fragment of 443 bp comprising the cleavage/packaging signal was found to be sufficient for cleavage and encapsidation of replicated concatemeric viral DNA. These results suggest that prDNA is a functionally important region of the genome of BHV-4. (+info)
(7/1277) Prenatal diagnosis in factor XIII-A deficiency.
Congenital factor XIII deficiency is a severe bleeding disorder that is inherited as an autosomal recessive trait. The condition is commonly due to absence of the factor XIII-A subunit protein in the plasma. The case of a baby is reported who showed typical clinical features of factor XIII-A deficiency, including recurrent bleeding from the umbilical stump and a life threatening haemorrhage after circumcision. Family studies were performed and molecular analysis, using a Short Tandem Repeat (STR) marker closely linked to the A subunit gene, allowed antenatal exclusion diagnosis to be undertaken in a subsequent pregnancy. The case highlights the importance of seeking a family history of bleeding disorders before surgery in the neonatal period, particularly if the parents are consanguineous. (+info)
(8/1277) Tandem repeat recombination induced by replication fork defects in Escherichia coli requires a novel factor, RadC.
DnaB is the helicase associated with the DNA polymerase III replication fork in Escherichia coli. Previously we observed that the dnaB107(ts) mutation, at its permissive temperature, greatly stimulated deletion events at chromosomal tandem repeats. This stimulation required recA, which suggests a recombinational mechanism. In this article we examine the genetic dependence of recombination stimulated by the dnaB107 mutation. Gap repair genes recF, recO, and recR were not required. Mutations in recB, required for double-strand break repair, and in ruvC, the Holliday junction resolvase gene, were synthetically lethal with dnaB107, causing enhanced temperature sensitivity. The hyperdeletion phenotype of dnaB107 was semidominant, and in dnaB107/dnaB+ heterozygotes recB was partially required for enhanced deletion, whereas ruvC was not. We believe that dnaB107 causes the stalling of replication forks, which may become broken and require repair. Misalignment of repeated sequences during RecBCD-mediated repair may account for most, but not all, of deletion stimulated by dnaB107. To our surprise, the radC gene, like recA, was required for virtually all recombination stimulated by dnaB107. The biochemical function of RadC is unknown, but is reported to be required for growth-medium-dependent repair of DNA strand breaks. Our results suggest that RadC functions specifically in recombinational repair that is associated with the replication fork. (+info)

redpajama_set_name: RedPajamaCommonCrawl


Visual Studio Code>Themes>Dark+ TweakedNew to Visual Studio Code? Get it now.
Just a simple modification to the default Dark+ theme.
This is just some minor tweaks to the Dark+ theme.
This theme is just a UI tweak of the default Dark+ theme from Microsoft. I also pulled in tweaks from Dark++ Theme by DryWolf.


The reason to wonder is obvious–we can hustle harder, but it is hard to manufacture more talent.
If you need to do something you've done successfully before, all other things being equal, you are more likely to beat the hard worker or the smart guy who have never done it before. You already know a lot of the answers.
If you've never done it, but you're smart, you will learn the answers or figure them out more quickly, which can mean you finish faster than the hard work guy if you work just as hard.
You can still get there on nothing but sweat, but you'd better hope the smart guy isn't trying very hard and there are no wise guy (!) who've already done it competing.
I'm a big believer that wisdom trumps all, even though most people who know me think I'm very smart and very hard-working.
Malcolm Gladwell has a great book called "Outliers" that focuses on the "10,000 hour rule." Gladwell claims that the key to achieving world-class expertise in any skill, is, to a large extent, a matter of practicing the correct way, for a total of around 10,000 hours. What you're learning with all that practice is what I'm calling "wisdom" in this piece.
Since that time, various others have argued that the 10,000 rule only applies to fields that are stable enough that practice matters. If the whole field changes in less than 10,000 hours, you're out of luck.
You can still have more experience / wisdom than anyone else pursuing the rapidly changing field. In addition, you may have meta-wisdom. That would be wisdom about how to approach anything in life for the first time, before you (or perhaps anyone else) has a chance to amass 10,000 hours.
Here are my takeaways on that meta-wisdom to help you be as successful as possible.
Why reinvent the wheel? Even if you do need a new mode of transportation, why not really understand the state of the art best practices before diving in?
There is so much knowledge accessible on the Internet today. The problem isn't finding answers, it's know which answers to choose. Anything that seems like it will benefit from Intelligence or Wisdom needs to be researched.
Learn how to get the most out of Google. Learn how to spot the experts from the charlatans, because it's literally become possible to position yourself as an expert using fake news. Learn to cross reference answers to confirm they are correct. Most of all, learn to be a critical thinker.
If you launch into a hyper-competitive arena that requires serious knowledge to succeed in, you're picking the hardest possible fight. By definition, that area will attract the hardest working, brightest, and most knowledgeable individuals.
Think traders on Wall Street. The best and brightest get hired because there's so much at stake. They have access to much better information than you or me. Why try to beat them at that game?
Now, what's better is a sleepy little niche that may still benefit from your intelligence and wisdom, but that doesn't yet have many sharp practitioners player there yet.
Set up your table there and go to work.
By the way—you want there to be a learning curve so that when competition inevitably shows up, you're way ahead of them and hard to catch.
I like spaces that have learning curves because as I just said, you can create a barrier to entry and you're not just selling a commodity based on cost. So, my ventures always involve a learning curve.
Consequently, I try to can gain as much wisdom as possible early on before I've invested much. Front load the areas that look like they'll require a lot of learning, in other words.
You want to start a business because you got a great idea for a product.
Product ideas are a dime a dozen. Lots of products are built and then fail. Your want to do things a little differently.
Instead of deciding on a business based on product, decide based on audience.
The hardest part about your business isn't the product–it's figuring out how to sell it. When you start with an audience, you are front loading the opportunity to gain that wisdom before taking much risk.
Choosing to thoroughly research an audience brings you so many advantages in terms of front loading the learning curves to stock up on wisdom early.
The biggest advantage is you don't have to quit your Day Job. You literally can't climb that learning curve any faster full-time than part-time. So do it part-time and reduce your risk further.
You have to be born intelligent, but Hard Work and Wisdom are things you can emphasize by choice.
You might still get beaten by a very smart person who works just as hard or harder than you and who has more wisdom. But the odds of that perfect storm happening are low if you do your homework diligently. Plus, you have the option of picking a market niche where you can see all the players and judge whether you can gain the advantage.
That's just one more reason to start with your audience!


G1 Ponies - Items tagged as "Other winged pony"
G1 Ponies refer to the First Generation of My Little Pony toys, which were made over a 10-year period from 1982 to 1992. In 1997, production started again with the G2 (1997 to 2003) line, followed by G3 (2003-2010) and G4 (2010-Present).
G1 Ponies are further broken down by year, with each year featuring new ponies and variations of previous ponies. Some ponies were available through mail order and special offers and were available over the course of several years. Pony Wear outfits and playsets were also sold during multiple years.
Some G1 ponies have been re-released in anniversary editions. The original 6 ponies from Year 1 were re-released in 2008 to celebrate the 25th Anniversary of the My Little Pony line, and again in 2018 to celebrate the 35th Anniversary.


text:
/************************************************************************
*
* CppSharp
* Licensed under the simplified BSD license.
*
************************************************************************/

#pragma once

#include <cstdint>
#include <vector>
#include <map>
#include <string>

#define CS_FLAGS
#define CS_IGNORE

#if defined(_MSC_VER) && !defined(__clang__)
#define CS_API __declspec(dllexport)
#else
#define CS_API
#endif

#define CS_ABSTRACT
#define CS_VALUE_TYPE

/** We use these macros to workaround the lack of good standard C++
 * containers/string support in the C# binding backend. */

#define VECTOR(type, name) \
    std::vector<type> name; \
    type get##name (unsigned i); \
    void add##name (type& s); \
    unsigned get##name##Count (); \
    void clear##name();

#define DEF_VECTOR(klass, type, name) \
    type klass::get##name (unsigned i) { return name[i]; } \
    void klass::add##name (type& s) { return name.push_back(s); } \
    unsigned klass::get##name##Count () { return name.size(); } \
    void klass::clear##name() { name.clear(); }

#define VECTOR_STRING(name) \
    std::vector<std::string> name; \
    const char* get##name (unsigned i); \
    void add##name (const char* s); \
    unsigned get##name##Count (); \
    void clear##name();

#define DEF_VECTOR_STRING(klass, name) \
    const char* klass::get##name (unsigned i) { return name[i].c_str(); } \
    void klass::add##name (const char* s) { return name.push_back(std::string(s)); } \
    unsigned klass::get##name##Count () { return name.size(); } \
    void klass::clear##name() { name.clear(); }

#define STRING(name) \
    std::string name; \
    const char* get##name(); \
    void set##name(const char* s);

#define DEF_STRING(klass, name) \
    const char* klass::get##name() { return name.c_str(); } \
    void klass::set##name(const char* s) { name = s; }

redpajama_set_name: RedPajamaGithub


The two most common neurodegenerative disorders in the elderly are Alzheimer's disease (AD) and Parkinson's disease (PD). While each has well-defined clinical and pathologic features and specific criteria for clinical and pathological diagnosis, some degree of overlap between these two disorders exists. Some AD patients develop extrapyramidal signs and symptoms characteristic of PD, some patients with typical PD develop a dementia, and both disorders can co-occur in the same individual. This, however, does not explain all or even most of the cases of PD with dementia. Another entity known as dementia with Lewy bodies (DLB) has been estimated to account for 15 to 20 of late-onset dementias and has been only more recently recognized as the second most common cause of dementia after AD (McKeith, Perry, & Perry, 1999 McKeith et al., 1996). In this chapter, we focus on the dementias associated with both DLB and PD with dementia.
In reviewing the PD literature, Lieberman (29) reported that 17 to 53 of treated and untreated PD patients without dementia demonstrate cognitive dysfunction. Unfortunately, few of the studies reported formal criteria for determining what did or did not constitute dementia, thus making it difficult to determine whether patients were in the early stages of dementia. As noted earlier, more recent studies suggest that formal neuropsychological testing may uncover mild cognitive deficits in 25 to 36 of PD patients at the time of diagnosis (22,23). When present in early PD, cognitive dysfunction is typically mild and most commonly involves bradyphre-nia (a slowness of thought) and subtle deficits in executive functions, recall, and or visuoperceptual spatial functions (30).
TABLE 3 Risk Factors for Dementia in Parkinson's Disease Lower socioeconomic status Family history of Parkinson's dementia Disease severity Susceptibility to levodopa-induced psychosis or confusion patients with PD on verbal fluency, attentional, and visuospatial tasks was associated with subsequent development of dementia. Woods and Tr ster (93) found that nondemented PD patients who met criteria for dementia at one-year follow-up evaluation demonstrated poorer baseline performance on measures of word-list learning and recognition, complex auditory attention, and executive function.
Parkinsonism following encephalitis lethargica during the influenza pandemic between 1916 and 1926 is known as postencephalitic parkinsonism (PEP). During the recovery phase of the acute viral encephalitis, parkinsonian rigidity developed with the most characteristic clinical features being oculogyric crises. The PEP brain has NFTs in the cortex, basal ganglia, thalamus, hypothalamus, substantia nigra, brainstem tegmentum, and cerebellar dentate nucleus (48). The distribution of the pathology overlaps with PSP and, in some studies, it has not been possible to distinguish the two disorders by histopathologic analysis alone (48). Biochemical studies of abnormal insoluble tau in PEP have features similar to AD with three major bands (68, 64 and 60 kDa) on western blot studies, and electron microscopy shows paired helical filaments similar to those in AD (49).
A characteristic parkinsonism with dementia Parkinson dementia complex (PDC) with a number of features that overlap with PSP (50) has been reported in the native Chamorro population of Guam since the 1950s (51). The frequency of PDC is declining in recent years for unknown reasons, and the etiology is unknown. The gross findings in PDC are notable for cortical atrophy affecting frontal and temporal lobes, as well as atrophy of the hippocampus and the tegmentum of the rostral brainstem (52). These areas typically have neuronal loss and gliosis with many NFTs in residual neurons.
Pharmacological manipulation of the dopaminergic system can take on two basic forms either targeting dopamine biosynthesis or destruction of nigrostriatal dopaminergic neurons. Both reserpine and alpha-methyl-para-tyrosine (AMPT) interfere with dopamine production and result in a temporary dopamine depletion lasting hours to days, whereas neurotoxicants such as 6-hydroxydopamine (6-OHDA) and (MPTP) result in midbrain dopaminergic cell death. Methamphetamine (METH) is a class of compound that selectively destroys axonal terminals of nigrostriatal dopaminergic neurons usually without significant cell death. Recently, other compounds, particularly pesticides and proteasome inhibitors, have been utilized as selective toxins targeting the dopaminergic system since the mitochondria of these cells display enhanced vulnerability during chronic exposure. The utility of compounds to generate animal models of parkinsonism are discussed in the following sections.
Levodopa is available with carbidopa as immediate release carbidopa levodopa 10 100, 25 100, and 25 250. It is also available in a sustained-release form as car-bidopa levodopa 25 100 and 50 200. An orally dissolvable form of immediate release carbidopa levodopa (Parcopa ) is available as 10 100, 25 100, and 25 250. Finally, levodopa is available with the COMT inhibitor, entacapone, in the following combinations Stalevo 50 (carbidopa 12.5mg levodopa 50mg entacapone 200 mg), Stalevo 100 (carbidopa 25 levodopa 100 entacapone 200), and Stalevo 150 (carbidopa 37.5 levodopa 150 entacapone 200).
In patients with parkinsonism, walking is slower than normal, cautious, and contained. The steps get smaller and the patient will eventually shuffle. In more advanced disease, she is flexed at the knees and hips and walks on her toes while sliding her feet forward. Her arms are adducted and flexed at the elbow, with her hands held in front of her thigh or abdomen.
The tremor of Parkinson's disease is present at rest. The hand tremor is most marked with the arms supported on the lap and during walking. The characteristic movement is 'pill-rolling' where movement of the fingers at the metacarpophalangeal joints is combined with movements of the thumb. The resting tremor decreases on finger-nose testing but a faster action tremor may supervene. The best way to evoke the tremor is to distract the patient, such as focusing attention on the left hand with a view to 'examining' the right hand or by turning the head.
Levodopa methyl-ester carbidopa effervescent tablets (CNP-1512) are currently approved for rescue therapy in PD in Italy (Chiesi Farmaceutici). Outside of Italy, the drug (V1512) is owned by Vernalis Pharmaceuticals. This preparation is approximately 250 times more soluble in water and can thus be easily dissolved and orally administered. Studies comparing the drug with standard levodopa preparations demonstrate a faster onset of action (by a mean of 8.5 minutes) and a longer total duration of action (mean 15 minutes longer) with fewer dose failures. A large 39-center European trial compared levodopa methyl-ester with standard levodopa in patients already on levodopa who were experiencing at least two hours of off time. At 12 weeks, subjects on levodopa methyl-ester tended to have less off time than levodopa (-39.4 vs. +3.4 minutes, P 0.07). No unexpected adverse events have been noted. Phase III North American and European studies are planned (4).
Until recently, standard neuroimaging techniques have had a marginal role in the diagnosis and follow-up of Parkinson's disease (PD). The diagnosis of PD is essentially based on clinical data (neurological examination and evaluation of therapeutic response) (UK Parkinson's Disease Brain Bank criteria). In the earlyphase the magnetic resonance (MR) examination may be negative. In other words MR is not sufficiently sensitive to the damage caused by PD. One-fourth of patients with a clinical diagnosis of idiopathic PD are subsequently found to have other degenerative disorders 11 . Like clinical examination, standard MR is scarcely specific and has a secondary role that is in fact limited to gross differential diagnosis with other neurological disorders. We examine the rationale of standard MR diagnostic imaging, the more advanced quantification techniques and the advantages and drawbacks of 3.0 T magnetic fields in PD.
It is hypothesized that there are three features underlying the voice disorder in individuals with PD (i) an overall amplitude scale down (75,76) to the speech mechanism (reduced amplitude of neural drive to the muscles of the speech mechanism), which results in hypophonia, hypoprosodia, and hypokinetic articulation (ii) problems in the perception of vocal loudness and effort (77), which prevent the individuals with PD from accurately monitoring and scaling their vocal output and (iii) difficulty in independently generating (internal cueing scaling) the right amount of effort (78) to produce adequate vocal output (loudness, prosodic inflection, and amplitude of articulatory movement). The LSVT has been designed to address these problems.
Resonance problems are not common in PD, but when they are present, the voice often sounds like a foghorn. The acoustic and physiologic nature of this phenomenon is not clear, and perceptually, it is difficult to determine whether the voice is hypernasal or hyponasal. Aerodynamic and kinematic studies suggest that velopharyngeal movements may be reduced in some of these individuals (22,52,56). Abnormal tongue posture may also contribute to the resonance in parkinsonian speech. The abnormal resonance may also reflect motor symptoms not directly caused by PD such as pharmacologically induced dystonic or dyskinetic movements of the velopharyngeal and or tongue muscles.
These investigators also found that 43 of IPD patients had a depressive disorder an additional 14 had depressive symptoms. It has been suggested that anxiety may be secondary in part to the antiparkinson-ian medications. A study by Maricle, Nutt, and Carter (1995) investigated mood and anxiety fluctuations associated with L-dopa infusion therapy in a small series of patients and found that mood and anxiety symptoms slightly preceded but temporarily paralleled fluctuations in motor tapping scores. The effects of L-dopa on mood and anxiety were not related to relief of parkinsonism. Mood change preceded changes in tapping scores and started dropping before tapping scores deteriorated. There was no relationship between the amount of mood change, severity of parkinsonism, and the extent to which IPD improved during L-dopa infusion.
Although Parkinson's disease (PD) is commonly regarded as a disorder of dopamine deficiency, it is actually a multisystem degenerative disorder. As nondopaminergic brain pathways are involved in the genesis of many symptoms, these cannot be successfully treated by merely increasing brain dopaminergic stimulation. The auto-nomic symptoms fall into this category, and thus management is often challenging. The autonomic features of PD affect cardiovascular function, gastrointestinal (GI) motility, urinary bladder function, sexual ability, and thermal regulation. A list of the common symptoms and signs of autonomic dysfunction is shown in Table 1. Although symptoms of autonomic failure typically present later in the course of the disease, rare case reports exist of autonomic abnormalities as the presenting feature (1). This chapter will outline the common autonomic features of PD and discuss treatment approaches for each.
In PD, severe EDS needs treatment, and first concurrent medications that may be sedating should be eliminated or reduced (Table 5). Modafinil (100-400 mg day), a nonaddictive sleep-wake cycle activator, is nonstimulating and the only drug that has shown efficacy in improving EDS in double-blind, placebo-controlled trials (87,88). A seven-week, double-blind, placebo-crossover study of modafinil (200 mg) followed by a four-week open-label extension (200 and 400 mg) study by Adler et al. (88) showed significant improvement in ESS with modafinil and improvement in clinical global impression scores for wakefulness in the open-label arm. Those with high ESS scores and a history of sudden onset of sleep should be advised not to drive alone or long distances. Dopamine agonists when initiated should be titrated up slowly, especially in older patients.
Visuoperceptual impairments are thought to occur in early PD, even when motoric task demands are minimized (62,63) however, some argue that visuoperceptual impairments are secondary to deficits in set-shifting, spatial memory, bradyphrenia, and dexterity (34,64). Visuospatial impairments do not appear to improve with dopamine replacement and do not reliably vary with motor on and off periods. Thus, if dopamine impacts visuoperceptual abnormalities in PD, it is probably in conjunction with other neurochemical or pathophysiological processes (65).
Selegiline and rasagiline, selective monoamine oxidase-B (MAO-B) inhibitors, have been hypothesized to exert a neuroprotective effect in PD by way of reducing physiologic stress associated with MAO-B oxidation of dopamine. Along with improvement in motor functions, several small, uncontrolled studies have found selegiline to be associated with improved global cognitive functioning, P300 latencies, and or memory in patients with PD (137-140). In contrast, selegiline was reported not to significantly impact cognition in a large sample of untreated patients with early PD (141). The potential cognitive effects of rasagiline in PD patients have not been evaluated.
Overall, based on clinical experience and the available scientific data, SSRIs and TCAs may be considered useful for the treatment of depression in PD, and the agent that provides the best overall clinical benefit-to-risk profile should be selected (168). Amoxapine and lithium should be avoided, given the propensity of these agents to worsen motor symptoms and the availability of safer agents (169,170). Additionally, the nonselective MAO inhibitors (e.g., isocarboxazid, phenelzine, and tranylcypromine) should be avoided in levodopa-treated patients due to the risk of hypertensive crisis. Several antidepressants, such as bupropion, fluoxetine, fluvoxamine, nefa-zodone, and paroxetine, are potent in vivo inhibitors of various cytochrome P450 (CYP450) drug-metabolizing isoenzymes (171,172). These antidepressants may increase the risk for drug interactions.
Atypical antipsychotics are typically used to treat psychosis in PD. Table 1 provides a summary of atypical antipsychotic studies in PD. The United States Food and Drug Administration (FDA) recently asked all atypical antipsychotic manufacturers to add a boxed warning to their product labels, saying that atypical antipsychotics, when used in elderly patients with dementia, were associated with a higher risk of mortality (54). However, since the deaths were primarily due to cardiovascular or infectious causes, it is unclear how the atypical antipsychotics cause increased mortality. Since psychosis can be difficult to treat in PD, it is likely that these agents will continue to be utilized until a direct cause and effect relationship is uncovered.
Goetz and Stebbins (5) described 11 PD patients in a nursing home with hallucinations, all of whom were never discharged from the nursing home and died within two years. In an open-label extension of the U.S. double-blind clozapine trial, only 25 of completers died over a 26-month observational period. Forty-two percent were in nursing homes, 68 were demented, and 69 were still psychotic (4). A separate study of 39 parkinsonian patients, treated with clozapine for psychosis, found that only 15 had died over a span of five years and 33 had been admitted to nursing homes (115).
Both reserpine and AMPT have been used to discover new dopaminomimet-ics for the treatment of PD, but since their effects are transient (hours to days), these models are primarily useful for acute studies. In addition, neither agent can duplicate the extensive biochemical nor pathological changes seen in PD. Consequently, other models with long-lasting neurochemical and behavioral alterations have been sought using site-specific neurotoxicant injury.


I am not sure about you, but I am always being told to slow down, take a break and take time to look after my well-being - to listen to what my body is telling me and take a step back from the increasingly fast paced life that we find ourselves living in. Honestly, I should probably take heed of this advice I frequently find coming in my direction as there must be a reason why many different people tell me the same thing, and when I think about it, I am constantly busy and in a state of what could be viewed as tension, or stress. I do tend to live life full on and 'full steam ahead' as some say - I actually find it difficult not to when I am living in Bangkok which, if you have ever been here, you will almost certainly agree, is a city that in itself if 'full-on' - it never seems to go to sleep and noise pollution is a phrase that can certainly be applied to most parts of this city, 90% of the time. Especially where I have found myself living is where the city is currently making ready to be its new business district, so new buildings of great heights seem to be flying up almost every other week (this might sound like a complete exaggeration, but I kid you not - this is happening). So everywhere I look I can see building sites and cranes that are almost always in motion, the work never stops. Then there is the added detail that I registered a company here roughly 4 years ago, that I have been steadily developing and growing with the help of my two business partners - each year becoming more busy, with more responsibilities and more of a variety of tasks to complete within consistent monthly delivery dates.
So with all of this in mind, actually it is little wonder why my close friends and families and even my co-workers are often giving me advice to actually take a look at myself in the mirror and forget everything else for a little while to reflect on my own wellbeing - ensure that I am not doing myself some damage now that will in the near or not too distant future have a crippling effect and put a big dampener and everything that has been achieved. Whenever I am receiving these recommendations and advice, something that comes up time and time again and certainly the most frequently mentioned cause of action is to seek out advice from a practitioner of some type of alternative medicine, get some natural treatment and allow them to carry out some of their practiced and age-old methods for analyzing and investigating my body and determine just how good a state it is in at this moment in time. As I am in South East Asia, I am in a good location to seek out this kind of medicine or alternative treatments, therapies and or packages. One of these trusted types of alternative medicines that I have taken quite a liking to, has to be the 1000's of year old method of Ayurveda - where the practitioner has trained extensively in listening and treating the body with what it is asking for to achieve a healthy and complete balance of the elements - earth, fire, wind & water.
Ayurvedic medicinal practices originated roughly 3000 years ago in India and have evolved gradually over the years, remaining at the heart of ancient Indian culture. The practice also known as Ayurveda; ayur - meaning 'life' and veda meaning 'knowledge' came from the great Rishis or Seers of and ancient India when they sought to find an understanding of the creation and physiology of the human body. They began by ways of deep meditation and thorough spiritual studies to analyse and understand the fundamentals of life, that they then organised into an elaborate system to compile India's philosophical and spiritual texts, called Veda of knowledge. Ayurveda is actually probably the world's oldest know practice of treating the human body and re-establishing true wellbeing. It was first recorded in the Veda which is the world's most ancient known literature and the practice has been passed down the generations orally from teacher to student, and to this day the way of treating different impurities and imperfections found within a person's body has for the most part remained in-tact and the same. This information alone captivates me and leads me towards believing that this would be the alternative medicine for me - if it has lasted for this long then surely it has been proven to achieve great results and surely it can do me wonders, perhaps increasing my daily energy levels and state of true happiness.
I have also in the past had an introduction into another Eastern Medicine, however that was one that originated in China and involved needled being inserted into pressure points across my entire body. If you have not guessed already, I am referring to acupuncture, and even though it is also a way of treating the body that has lasted the times, coming from thousands of years ago, it really was not for me. I found the feeling and even the thought of having needles poking into different parts of my body very uncomfortable and didn't react too well to the treatment - perhaps because of not being able to properly relax while being treated as I have always had a slight fear of needles and wince at the point of insertion. So it is Ayurveda for me and after doing my research, I would recommend it for any of you who are suffering from any kind of illness or unbalanced state of being. Especially if you have already tried various Western medicines that perhaps didn't properly cure you from your unwell state. Why not try a medicine that has been around on this globe longer than anything else I can think of.


Abstract Using proprietary data on equity lending supply, loan fees and quantities we examine the link between institutional ownership structure and the market for equity lending and stock prices. We find that both total institutional ownership and ownership concentration - measured by the Herfindahl index, single largest holding, and number of investors - are important determinants of equity lending supply and short sale constraints. More concentrated ownership structures increase short sale constraints - including loan fees, recall risk and arbitrage risk - and forces arbitrageurs to decrease demand for equity borrowing and demand greater compensation for borrowing stock. The results suggest that the impact of institutional ownership structure in the equity lending market may create limits to arbitrage.


text:
Hearst's magazine workers protest mandatory return-to-office through the National Labor Relations Board
Tue, November 9, 2021 by ABC News
iStock/littlehenrabi
HomeBusiness NewsHearst's magazine workers protest mandatory return-to-office through the National Labor Relations Board
(NEW YORK) — After more than a year of working remotely through the COVID-19 pandemic, staffers at Hearst's magazines are fighting back against a mandatory return to office.
Workers at the magazine-publishing division of Hearst — which runs outlets including Cosmopolitan, Good Housekeeping and Men's Health — have filed an unfair labor practices charge against their employer with the National Labor Relations Board via their union, the Writer's Guild of America East.
The document filed with the NLRB and shared with ABC News by the union alleges unfair labor practices because the management failed to negotiate with workers in good faith over return-to-office protocols.
The labor action from the magazine journalists comes as a slew of companies across the country are now seeking to bring employees back into the office and face new resistance after some 20 months of remote work during the health crisis.
Record-high levels of people quitting their jobs as the pandemic wanes and other unique labor market conditions have also been linked to workers being emboldened to negotiate for what they want in the workplace recently, especially as major companies have reported struggling to find staff.
Over 300 employees (out of a bargaining unit of some 450 people) from Hearst's magazines division also signed a petition that was delivered to management demanding workplace location flexibility.
"We, the undersigned, trust in our colleagues to perform all their work responsibilities from the location that is most suitable to their needs. We have seen our colleagues adapt to unprecedented changes in our work lives without a drop in productivity," the petition, shared with ABC News by the union, states. "We do not believe that a return to office is the same as a return to work, because for all Hearst employees, we have never stopped working, regardless of our location."
The petition adds that while some employees require access to the office to do their work, they are simply seeking a "continuation of the functional norm that we have reached as a result of our extraordinary circumstances, with employees and teams able to make decisions that are appropriate for their work needs."
In a Twitter thread posted by the Hearst Magazines Media Union, the group says that they have been seeking to negotiate with management "for months" over return-to-office plans but still feel in the dark. The thread adds that it was only four business days before the scheduled return that some New York-based employees learned of the COVID exposure policy, and that many health and safety questions remain unanswered.
"It's our position that by barreling ahead with these last-minute plans, management is making a unilateral change to our work circumstances without adequately bargaining over the change as required by federal law," the union tweeted. "We are ready to cooperate with any investigation the NLRB deems necessary and are hopeful this process will reinforce to the company how serious we are about workplace safety."
Some journalists working at Hearst have weighed in on the debate on Twitter, arguing flexible work arrangement offers more time to spend with family and more.
A Hearst magazine's spokesperson did not immediately respond to ABC News' request for comment on Tuesday.
"We recognize that returning to the office is a big step and that some people are apprehensive about it," Debi Chirichella, Hearst's president, said in an email to staff last month, according to the New York Times, which reported that Hearst is seeking employees to be in the office at least three days a week. Chirichella continued: "Adjusting to this new way of working will require the same flexibility, patience and collaboration that we all demonstrated when we began working from home."
Data from the Department of Labor indicates that many companies are in the process of recalling workers back to their offices. The DOL said that 11.6% of employed person's teleworked because of the pandemic last month, down from 13.2% in September.
NYC entertainment industry workers worry about future amid show cancellations
Striking Kellogg's workers to vote on tentative deal as lawmakers double down support for unions
Biden administration accelerates plans for a national EV charging network
Kellogg restarts talks with workers as strike enters seventh week
John Deere workers approve new deal after monthlong strike
Amazon to pay $500,000 to California regulators after allegations of failing to properly notify workers of COVID-19 case numbers
Conditions as of 11:53am


text:
TV ReviewsMy Brilliant Friend
My Brilliant Friend's gripping second episode reminds us that some roads lead nowhere
Filed to:Recap
Elisa Del Genio, Ludovica Nasti
Photo: Eduardo Castaldo (HBO)
"Christmas won't be Christmas without any presents," grumbled Jo, lying on the rug.
"It's so dreadful to be poor!" sighed Meg, looking down at her old dress.
"I don't think it's fair for some girls to have plenty of pretty things, and other girls nothing at all," added little Amy, with an injured sniff.
"We've got Father and Mother, and each other," said Beth contentedly from her corner.
"I Soldi (The Money)"
There's precious little like contentment in "I Soldi (The Money)," the tense, taut second episode of My Brilliant Friend, but it's not a non-existent quality. Moments of warmth, and even joy, bubble up on screen: Lenú and Lila retrieve their hoarded cash to buy a book and dream of better things; they read Little Women in the sun; they holler together inside a tunnel; Lenú reads Lila's book on a sunny, breezy rooftop and marvels at her friend's pail of words. All lovely. All peaceful. Each, in its way, a moment of tranquility and loveliness.
This isn't an idyllic childhood we're witnessing, however. As such, these moments end almost before they can be wholly enjoyed, and some of them are not without an undercurrent of something sour or sore. Lenú's family celebrates her excellent test scores as her mother's resentment permeates the room. A book purchase isn't just a moment of glee, but a possible escape route. And a long, gray road may or may not truly lead to the ocean, an adventure that may or may not be a joyful act of friendship.
Director Saverio Costanzo makes sure these sour spots can be spotted from the beginning. After receiving a (pretty threatening, if we're honest) cash gift from suspected doll-stealer Don Achille, the girls race off to hide their cash, unwilling to surrender it to their families and unsure of where it should be spend. Deliberate postponement follows, until Lila strikes upon an idea that will, she says, allow them to turn that bill into many bills. Mercifully, she doesn't suggest that they get involved with some sort of child's Neapolitan pyramid scheme, but instead announces that they'll be buying Louisa May Alcott's enduring novel Little Women, because reading that book will teach them to write one of their own.
Sometimes the narration of a protagonist in voiceover can be a lot, even when it's absolutely necessary to understand the events taking place or the emotional state of the character. (Example: Despite Caitriona Balfe's excellent performance as Claire Fraser, the narration on Outlander is often more distracting than anything else. Some friends of mine call it "Claire-ification." Not good.) Here, though, it's indispensable, used extremely judiciously and always in beautiful language (often straight from the novel) that heightens the sensory experience while adding to the emotional and psychological layers already present. Such is the case with the older Lenú's description of one of the qualities she most admired in her friend. Lila, she tells us (paraphrasing here) is a person who commits to her actions with every fiber of her being; even when the acts are small or intimate one, she follows through and takes no half-measures. It's easy to understand what would be so alluring about that quality. If listening to Lila talk about words doesn't make you immediately want to start writing a novel, who even are you?
These are two exceedingly bright girls. Lenú downplays her own intelligence, emphasizing how her abilities pale in comparison to Lila's jewel-bright, dazzling mind, but even that realization indicates a beyond-her-years self-awareness, as does her realization about Lila's possible intentions on their ocean adventure and her ability to forgive her with ease. Two such brilliant minds should have no trouble making their way out of the pale courtyard to the ocean and well beyond, but the deck is stacked against them both, and one decision, hesitatingly made by one adult, sets the two friends on divergent paths. And that brings us back to Little Women, the opening lines of which begin this review.
It's not. The poverty of the families in Lenú and Lila's neighborhood is never out of frame; both families balk at the suggestion that they pay money to lose help by sending their daughters for additional schooling. It's an option not even available to some of their classmates, and it's only the begrudging but determined acquiescence of Lenú's father that sets her on a possible exit route. They are poor. They are girls. If there's a way out, it's a hard one, and only one of them comes close to finding it. The other gets hurled out a window for her trouble.
In another coming-of-age story, Lila's mother would defy her father to get her past that test, or her father would unwillingly bow to her brother's demands. Her teacher would fight harder, or volunteer to teach her for free. She'd study on her own and win a scholarship. But this isn't that story. It's not even that story for Lenú, who endures abuse emotional, verbal, and physical in nature whenever the topic of school is raised. But for Lila, her only safe havens are her brother Rino (for whom, one assumes, she named the son who calls the adult Lenú in the first episode's opening moments) and Lenú herself, the friend with whom she entrusts her book even as her jealousy and fear are apparent. From every other corner she meets violence and rage. Even her teacher, her champion, writes her off, and encourages Lenú to do the same.
My Brilliant Friend makes very clear points about the many societal factors—financial, patriarchal, familial—that seem sure to keep one of these two brilliant friends from becoming what they have the potential to be. Yet it never stops being about the friendship of two young girls. Some of that is the writing, as the source material pulls this off with similar ease, and some of it is the direction, as Costanzo wisely sticks with Lenú and Lila even when their concerns have larger implications and resonances (no shots of dozens of little girls walking off to school, for example). But a great deal of it is due to the performances of Elisa Del Genio and Ludovica Nasti. It's possible, even likely, that this will be the last episode that centers on these two—we've got to keep moving in time, and another pair of young actors await us as Lila and Lenú enter their teenage years. But they've done even more than was asked. They communicate the interior lives of their charges, and they make us believe in their bond, but they also lend all these big ideas and immediacy and urgency that's not easily shaken.
When Lila lies crumpled on the pavement, muttering "I'm not hurt" as she stares at her friend with an arm clearly broken, it's an end of a road, but Nasti's remarkable performance ensures that the ghost of that potential future never leaves the frame. A girl with that strength and invention, a girl who reads Little Women to learn how to write a book and then does so, a brilliant girl—there's another path she might have taken. Maybe it leads to the ocean. Maybe it leads to a University. Wherever it goes, she can't follow it, and maybe it's the fuel she has stored for a journey she'll never take that we see burning in her eyes as she takes some words from her pail and puts them in order, telling herself a story: "I'm not hurt. I'm not hurt. I'm not hurt."
The saga of Don Achille and his neighborhood foes continues, with Lila seeming to piece together that Solara family was somehow involved in both the death of Achille and the subsequent arrest of their inexplicable but sure-as-hell convenient new hire.
The violence is incredibly well handled. This episode is so, so hard to watch, because so much of what they experience seems routine. It's only the window that seems to startle anyone—well, that, and Don Achille's knife to the neck.
The costumes, by Antonella Cannarozzi, are incredible. Every single one looks like it's been tended to often, and like it's not often cleaned.
See you next Sunday!
Like a fascinating new companion, My Brilliant Friend immediately pulls you into its orbit
Park Chan-wook brings swooning romance to AMC's spy miniseries The Little Drummer Girl
Jinn tells a familiar coming-of-age story from a fresh point of view


text:
We Are SOSC
Beyond Sports
Healthy Lifestyle Challenge
Tag: Breakfast With Champions
Albertsons/Vons/PavilionsBreakfast With Champions
SOSC To Host a Weekend of Virtual Inclusion to Bring People Together During the Health Crisis
Special Olympics Southern California will host A Weekend of Virtual Inclusion on June 6 and 7 as an interactive, alternative experience to the canceled 2020 Summer Games Championship. Due to the impact of COVID-19, the Spring Sports Season, including Summer Games, was canceled, but SOSC still seeks to unite all people and celebrate the passion ...
By wearesosc	on May 19, 2020
50th AnniversaryBreakfast With Champions
Nordholm Family Leads by Example
By Alexandra Dickens The Nordholm family has stayed true to Special Olympics Southern California's mission. Their story is one that will not be forgotten, as the Nordholms have helped change lives for the past 50 years "through the simple power of sport." Their contributions will be celebrated Saturday at this year's Breakfast with Champions from ...
By wearesosc	on June 4, 2019
50th AnniversaryAlbertsons/Vons/Pavilions
Games Set to Begin Saturday
LONG BEACH, Calif. (June 7, 2018) – The 49th annual Special Olympics Southern California Summer Games is set to begin on Saturday, June 9 with Opening Ceremony at 9:30 a.m. The Games run through Sunday, June 10 and end with Closing Ceremony at 3:00 p.m. All told more than 1,100 athletes will represent 25 Southern ...
2018 Summer Games: One-Month Countdown
LONG BEACH (May 9, 2018) – One month from today, the 49th annual Special Olympics Southern California Summer Games will begin with Opening Ceremony on the campus of California State University, Long Beach on June 9. The Summer Games will run through Sunday, June 10 and will begin a year-long celebration of Special Olympics Southern ...
By wearesosc	on May 9, 2018
Johnny Hekker to be Keynote Speaker for Annual Breakfast
LONG BEACH, Calif. (Mar. 22, 2018) – Special Olympics Southern California's (SOSC) annual Rafer Johnson Breakfast with Champions is part of the opening day of the annual Summer Games on June 9 at Cal State University, Long Beach. Los Angeles Rams' All-Pro punter Johnny Hekker will serve as the keynote speaker for this year's event, ...
By wearesosc	on March 22, 2018
Breakfast With ChampionsEvents
INSIDE SOSC: Fun, Inspiration Beyond the Games
Breakfast With Champions Steve Alford, the UCLA men's basketball coach and keynote speaker of the event, recounted a story about how he didn't have the 1984 Summer Olympic Games on his radar when he was a 19-year-old growing up in Indiana. Little did he know that it would be the start of something much greater, ...
By wearesosc	on June 13, 2017
Breakfast With ChampionsFundraiser
Champions a Highlight to Annual Breakfast
LONG BEACH, Calif. (June 1, 2017) – The annual Rafer Johnson Breakfast With Champions is held on the opening day of the Special Olympics Southern California Summer Games and celebrates the passion of sports. The Breakfast will once again live up to its name as the tradition of champions will be a highlight of the ...
Stevens to Earn Humanitarian Award
BUY TICKETS LONG BEACH (May 16, 2017) – Special Olympics Southern California is proud to announce Tom Stevens as this year's Rafer Johnson Humanitarian Award winner. Stevens, chairman and president of Los Angeles Capital Management, started his relationship with Special Olympics Southern California as a coach in the 1990s. He has chaired Breakfast with Champions ...
Steve Alford Named Keynote Speaker for Annual Breakfast
LONG BEACH, Calif. (May 2, 2017) – UCLA Men's Basketball Head Coach Steve Alford has been named the keynote speaker for Special Olympics Southern California's (SOSC) annual Rafer Johnson Breakfast with Champions. The breakfast brings leaders of the business and sports communities together to honor the accomplishments of Special Olympics athletes. The breakfast will be ...
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text:
Q: React Typescript: Cannot read properties of undefined The console is showing a new Object but I still get the error
const GetNo = (): string => {
        console.log(record);
        if (record.no !== "")
            return record.no;   //<-- Cannot read properties of undefined
        else
            return todos[todos.length - 1].no + 1;
    }

console:

EDIT:
record is type of object (see picture above) and im creating it via Button onClick where i modify a state this.setState({ selectedRecord: new ToDoClass() . After that I redner the FC with the form.
EDIT 2:
I tried the new Syntax:
const GetNo = (): string => {
        if (record == null) {
            console.log("1");
            return "2";
        }
        else if (record.no != null) {
            console.log("2");
            return record.no;
        }
        else {
            console.log("3");
            return todos[todos.length - 1].no + 1;
        }
    }

and when the record is: new ToDoClass() it return in the console a 2 but it should go inside the first statement?!

A: Your object record is defined outside of the function and may not be initialized at the execution time of the function.
I recommend you to:

*

*Pass the object as a parameter of the function

*Check that record is defined

By the way if you're using Typescript and there is a possibility that the record is not defined when passed to the function, you should get a warning at the line where you call GetNo(record).
const GetNo = (record: Record): string => {
   if (record) {
     // ...
   }
}

I hope it will be helpful!

A: I don't know why it behaves like this but I solved it with a Try-Catch statement.
const GetNo = (): string => {
   try {
      if (record.no !== "")
         return record.no;
      else
         return todos[todos.length - 1].no + 1;
   }
   catch {
      return "0";
   }
}

redpajama_set_name: RedPajamaStackExchange


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text:
La lingua Banjar (in Banjar: Bahasa/Basa Banjar; in indonesiano: Bahasa Banjar; in Jawi: بهاس بنجر) è una lingua austronesiana parlata dal popolo Banjarese della provincia meridionale del Kalimantan in Indonesia. Poiché i banjaresi erano storicamente dei commercianti nomadi, il banjarese è stato parlato in tutta l'Indonesia moderna e nel mondo malese.

Note

Altri progetti

Collegamenti esterni

Banjar

redpajama_set_name: RedPajamaWikipedia


Amazing real-time puzzle with real physics and pink bunnies.
Cute and detailed graphics, watch random actions of the bunnies while they jump, fall, evade arrows and more!
Great fun for any age, SIMPLE and PRECISE controls!
FOUR WORLDS of PURE FUN, each one with 60 LEVELS of mind blowing challenges.
COLLECT STARS - The more cunning you are, more stars you get!


text:
EXO HOSTING blog
Terminate Agreement Of
offences and are therefore so serious that they can terminate a contract. Sometimes contractual obligations and obligations simply do not work. You may be dissatisfied with the way the other party is fulfilling its obligations, or you no longer need its services. In these cases, you can send a termination contract to clarify that the contract is terminated. The termination agreements set out obligations that existed beyond termination. The parties to the original contract must sign a termination agreement. These agreements provide that the parties involved have reached a mutual agreement to terminate the contract. You can include an optional reciprocal release of claims. An end-of-business contract officially terminates a business relationship. Typically, it is one business and one or two companies.
Sometimes you have the option to exit a contract inside a particular window. It is important to understand your contractual obligations before signing an agreement. If you have questions about contractual terms, rules and language, contact a legal expert first. This can protect you from the legal consequences in the future. If, for example, the speaker is seriously injured and no one can replace him, that would be unreasonable. In this scenario, the company has the right to terminate the contract. With the law as it is, performance delays – even outside the control of the parties – can lead to rights to terminate bad contracts and business relationships that have become entangled. To understand how to terminate a contract, it is necessary to deal first with the definition of a contract. As we have already covered, a contract is defined as a series of conditions agreed by the agreeing parties with capacity in exchange for something. It contains an offer, acceptance and consideration, also known as exchanges of values. A contract requires both parties to meet certain obligations for a specified period of time.
There are four main ways to terminate contracts (there is a difference): and if a contractor tries to terminate a contract and is entitled to it, he or she is itself in a negative offence. As a general rule, termination agreements come into effect on the date indicated by the parties. Sometimes these agreements are triggered in another way, such as. B: a contract is essentially terminated as soon as the obligations set out in the contract are fulfilled. Parties should retain documentation that they have fulfilled their contractual obligations. The documentation is useful if the other party attempts to challenge the performance of your contractual obligations at a later date. In the event of a dispute, a court requires proof of the contract`s performance. Imagine, for example, Company A signs a contract with Company B for the delivery of small green widgets each month to Company A suppliers.
Instead, Company B provides large red widgets that are unusable for suppliers. This would be, if the treaty provides, a substantial offence. Company A could terminate its contract with Company B and seek damages in the event of non-compliance with the terms of its agreement. If the parties to a business contract agree to terminate by reference to these conditions, are they in a position to do so? The purpose of terminating the contract is not always to terminate the partnership. It could also mean that the relationships or services offered have changed or that contract services have already been concluded. The termination of the contract could also open up discussion on the evaluation of the services provided so far. Intercom informs users in their terms of use contract that in the event of termination, their "right to use the services, access the site and any content will be immediately cancelled." In order to legally terminate a contract, a legal representative would have to enter into a physical release contract.
Exoman
Exoman má najširší záber tém, keďže píše rukami exákov :)
Ycdsb Oecta Agreement
Who Must Agree To The Final Plea Bargain Agreement
What Is The Meaning Of Agreement
What Is A Provider Agreement
What Agreement Served As The Basis Of Feudalism
© EXO TECHNOLOGIES, spol. s r.o.


With usability becoming an increasingly important competitive issue in the global software industry, Bahatech Technology has come up with a structured approach towards analyzing software systems to ensure that they meet the needs of users in various environments with varying levels of computer experience.
Our goal is to ensure that your product is accessible, appealing, consistent, clear, simple, navigable and forgiving of user blunders.
Recommendations on all problems that are found in our usability analysis are then made to overcome usability failures as well as to identify its impact on the business in terms of ROI.


text:
Charlottesville Mural Project announces new mural for Meals on Wheels of Charlottesville/Albemarle
Published Thursday, Nov. 26, 2020, 9:41 am
Federico Cuatlacuatl and Chicho Lorenzo. Photo courtesy The Bridge Progressive Arts Initiative.
The Charlottesville Mural Project and The Bridge Progressive Arts Initiative are partnering with Meals on Wheels of Charlottesville/Albemarle and neighborhood students and school faculty in a new mural by Charlottesville-based artists Federico Cuatlacuatl and Chicho Lorenzo.
In an effort to expand students' knowledge and appreciation for their community, the muralists and students are incorporating design elements that spotlight the presence of Meals on Wheels in the Rose Hill neighborhood and include insight from program clients who have lived in the community for decades.
Students will be able to take home a portion of mural cloth, which they will paint and return for incorporation into the mural design.
"While distance learning has posed significant challenges, we've managed to use video and technology to bring the perspectives of neighbors and the expertise of experienced muralists directly into the virtual classroom. This is turning out to be a great learning opportunity for the students and a bright community-building effort in a difficult time," said Alan Goffinski, director of The Bridge Progressive Arts Initiative.
"We are thrilled to be a part of this amazing project, especially with the opportunity to work with the local students and faculty and these two wonderful artists. We are so appreciative of the efforts of Alan to keep this project alive through the current environment, working to find new ways to bring everyone together," said Leigh Trippe, director of Charlottesville Meals on Wheels.
This project is made possible through generous funding from The Fund at CACF, National Endowment for the Arts, and Virginia Commission for the Arts.


Mosquitoes transmit dangerous diseases, killing more people than any other animal and prompting the recent War on Mosquitoes. A new study shows that a method for training mosquitoes not to bite specific humans could be as effective as using insect repellents like DEET.
A graphic from Bill Gates' blog clearly illustrates that the mosquito causes more deaths per year than any other animal on the planet. This killer insect has a nasty reputation for spreading the disease around the globe, prompting what some have called The War on Mosquitoes. A recent experiment could be a turning point in this battle, as it equips us with a surprising and potentially revolutionary weapon — the ability to train mosquitoes.
According to a study published in Current Biology, when you slap at a mosquito that is about to bite you, it learns to associate your personal scent with that life-threatening experience and will avoid you in the future. This is the first demonstration showing that mosquitoes are able to both learn and remember.
It turns out that mosquitoes can learn and remember.
As described by Jeff Riffell, the study's lead researcher and University of Washington neuroecologist, in an interview with National Geographic, "They're essentially Pavlov's mosquitoes." He is referring to the famous experiment in which dogs are trained to salivate on command, which is comparable to mosquitoes being trained to avoid certain humans.
Mosquitoes don't bite at random. They are drawn to specific scents which are more alluring than others. The human scent, generally speaking, is particularly attractive to mosquitoes. But, when a person slaps at a mosquito, they usually create small vibrations on the skin that interrupt the insect's attempt to bite.
In this study, the researchers recreated these vibrations in 20-minute sessions and found that, when the mosquito bite was disturbed by these vibrations, the insect avoided that scent for up to 24 hours. This level of effectiveness was even likened to publicly-available insect repellent that contains DEET.


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Using These 3 R's To Improve Your Handicapping
By Ray Wallin
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If you do a web search for "3 R's" you get a lot of interesting results.
For the environmental minded, there is "Reduce, Reuse, and Recycle," which helps to cut down on the waste we throw away, but doesn't make us a buck at the track. In the world of animal testing, there is "Replacement, Reduction, and Refinement," which helps to find more humane ways to treat animals, but again isn't going to help you hit that big winner.
Instead, there are three other R-words that when followed will help you generate more consistent winners that you can be confident about. If you ask anyone who makes their living playing the races what makes them confident in their selections, you will get the same answers.
1) Rigor
How well do you keep records of your handicapping? Do you track the performance of every figure or angle that you use when selecting your contenders? Do you break down the results by conditions within the race?
An old crusty horseplayer I knew from the misspent days of my youth hanging out with my Uncle Dutch on the apron of the Monmouth Park grandstand summed up the difference between a winning horseplayer and a losing one. "A losing horseplayer can tell you what horse he had when he hit the big payout, the winning horseplayer can tell you what types of races he wins on."
Folks who win consistently don't remember that Pick 4 they hit at Saratoga last summer or the big trifecta that nailed at Belmont Park three summers ago. They will tell you that they look for early speed horses with an advantage or that they like to play the double of Pick 4.
The winning handicapper focuses on the process, not the one-off outcomes. The winning handicapper keeps meticulous notes and details on how each type of wager they place performs under different conditions. They know where their figures work and where they don't. They know when to play a specific spot play or play against a strong favorite.
By definition, rigor means the quality of being extremely thorough, exhaustive, or accurate. It is an added bonus if you are all three. Most handicappers don't keep good records. Even fewer keep great records. If you want to feel strongly about your picks and know what is profitable, have rigor in your approach to your record keeping, it will give you confidence in what you know works versus what you think will work to make a profit.
2) Responsibility
Are you in control of your bankroll or do you make stupid bets from time to time? Have you ever said after a losing bet, "I don't usually play this type of race," before tearing up your tickets?
I think back to my days of gracing the second floor of the old Meadowlands grandstand. I would watch our friend The Schnoz play night after night and lose most nights. It wasn't because his handicapping was flawed, in fact he was a good handicapper. Rather he was not responsible with his bankroll. He would play races that he didn't feel overly confident about because he had a "hunch." Mix in a couple of drinks later in the night and the bets got larger and more carefree. All this detracted from how well he could handicap a race.
There is no one-size-fits-all approach to money management. What works for me might not work for you. If you ask ten different professional horseplayers how they manage their bankroll, you will get eleven different answers. Some folks use a percentage of bankroll system, while others use a set amount by wager type or by confidence level. Regardless, they watch their bankroll like a hawk and are accountable for each penny they have.
You could be the greatest handicapper in the world with the best kept records of anyone who ever sat down in an OTB, but if you aren't responsible with your bankroll, you will never turn a consistent profit.
3) Reproducibility
Our friend Rail Guy is notorious for not being consistent in his approach to handicapping the races. He is a little scatter-brained at times and is the first one to point out after the race is over that the first-time starter that won "was a sure thing out of da Native Dancer bred sire" or that there was "no way dat anyone could run with dat five on the da front end."
How many times after a race, while doing a post-mortem, have you said to yourself, "how could I have missed that lone early speed horse?" How many times did you forget to look at the comments section to see if the horse had an excuse for that lousy last race or two?
What could we do to make sure he doesn't miss those easy winners in the next race?
One of the most important aspects of anyone's ability as a handicapper is to be able to handicap the races consistent time after time. Some newer handicappers that I have worked with in the past have benefited from having a checklist approach to each race. This is a prompt for them to analyze the pace, class, speed, pedigree, form, any figures, and look for any spot play angles in each race. Over time they need the checklist less and less since they have developed good handicapping habits, though many still find it comforting to have it with them in case they want to refer to it.
While not every factor, figure, or angle will be considered as strongly in each type of race, having a step-by-step approach to handicapping means that you won't miss the obvious early speed horse or stellar pedigree when you are reviewing the past performances of each entrant.
The goal of every handicapper is to be profitable at the races. By being rigorous in your approach to handicapping, being responsible with your bankroll, and making your handicapping process reproducible, you will be able to enjoy these three R's – Rest, Relaxation, and Riches.
Ray Wallin
Ray Wallin is a licensed civil engineer and part-time handicapper who has had a presence on the Web since 2000 for various sports and horse racing websites and through his personal blog. Introduced to the sport over the course of a misspent teenage summer at Monmouth Park by his Uncle Dutch, a professional gambler, he quickly fell in love with racing and has been handicapping for over 25 years.
Ray's background in engineering, along with his meticulous nature and fascination with numbers, parlay into his ability to analyze data; keep records; notice emerging trends; and find new handicapping angles and figures. While specializing in thoroughbred racing, Ray also handicaps harness racing, Quarter Horse racing, baseball, football, hockey, and has been rumored to have calculated the speed and pace ratings on two squirrels running through his backyard.
Ray likes focusing on pace and angle plays while finding the middle ground between the art and science of handicapping. When he is not crunching numbers, Ray enjoys spending time with his family, cheering on his alma mater (Rutgers University), fishing, and playing golf.
Ray's blog, which focuses on his quest to make it to the NHC Finals while trying to improve his handicapping abilities can be found at www.jerseycapper.blogspot.com Ray can also be found on Twitter (@rayw76) and can be reached via email at ray.wallin@live.com.
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It was confirmed earlier that Moto G4 will launch in India on 17th May, but it was unclear at that time whether Motorola will launch the G4 Plus or not. But yes, Moto G4 Plus will hit the shelves soon as we got the first look at the Moto G4 Plus.
The Moto G4 Plus looks pretty nice and looks like the specs are similar to what we heard via leaks and rumors. There is a 16MP rear camera and 5MP front camera. This time, there is a physical home button on the Moto G4 Plus, which also doubles as a fingerprint scanner. The phone sports a 5.5-inch 1080p display. The phone is powered by an octa-core processor, coupled with 2GB of RAM. However, we're not so sure about the exact processor details yet. There is a 3000mAh battery under the hood and seems like the Moto G4 Plus supports Turbo charging as well.
The back of the phone is just quite like the other Motorola smartphones, but it looks a little flat compared to the older Moto G. There is the camera module, below which there is dual tone LED flash and there is laser as well above the camera sensor. Below the camera we can see the traditional Motorola dimple and remain part is clean. That's all the information we have right now, join us on Facebook for more updates.


So, this comic makes Niles look a little more manic than he really is, but every single one of these mac & cheese recipes was something he actually dreamed up. I'm pretty sure the Reverse Mac & Cheese would end up being just awful to eat, but it's still an exciting idea. I'm also pretty sure he got the idea from some dishes we ate at iNG when I did a live drawing night there a few weeks ago. The dessert had a silky sweet sauce made from brioche, and it was amazing.
The Poutine mac sounds a little obscene, but I'd love that Buffalo on Steroids one, or the Basque one. The mac that Niles ended up making wasn't any one of these, but it was amazingly delicious. Tune in next Monday for the recipe!
Guys, Niles knows not to shake babies, I promise. He just really likes saying things that will shock me.
He's also pretty good at making salad dressings, and I definitely recommend this one. It's light and savory and really delicious without being overwhelming.
My brother was watching me draw this thing, and he asked which bao was the best bao. I have, unfortunately, not had the opportunity to try all of the delicious buns on this page, but I immediately pointed at the bánh bao anyway. In Chicago, you can get them at Ba Le and at Nhu Lan, and they are a delicious pocket of awesomeness, packed with a filling of ground pork and vegetables and spices, slices of Chinese honey sausage, and a hard boiled quail egg. It's a soft warm spicy hug that you can eat.
If the honey sausage and quail egg are too weird for you (and they're not for everyone), Chicago's Chiu Quon bakery makes some incredibly delicious Chinese baozi, with a bunch of different fillings to choose from.
When Niles and I were in Japan a few years ago, I was intensely jealous that you could get fresh piping hot nikuman at every convenience store. Even the ones at the 7-11 were delicious!
Anyway, that's enough of bao for now. I promise next week I'll have something else to write about.
In the meantime, did you know that there are new League of Courteous Cyclist shirts and hoodies in my store? Also there's a new Twin Peaksy print, which is damn fine.
The Birth of the Bao!
Hey everyone! Happy New Year! Guess what one of my new year's resolutions is? It's to post a comic here ONCE A WEEK AT LEAST.
So I'm back. Hi! And with a history lesson to boot. I never would have thought I'd find myself researching military uniforms in 3rd century China as a part of this comic. Zhuge Liang is a pretty interesting character, with a number of innovations to his name. I think we can be fairly certain he didn't actually singlehandedly invent steamed buns, but I suppose it's possible, and it's a great story nonetheless. Plus, baos are one of my favorite things, with their soft pillowy dough and their delicious savory insides, so I'm happy to write about them regardless.
I'm still as insanely busy as before, juggling 800 projects at a time… but I really missed Sauceome, and I missed having a regular outlet to talk about food and things. So check back here on Mondays, I'll be back to a regular schedule this time, I swear.
– I illustrated and designed these kickass hot sauce labels for Fat Rice, one of my favorite Chicago restaurants. This project was a hell of a lot of fun, and I'm super happy with the results. Plus, I designed a bunch of shirts for them too, so you should 1) go eat there and 2) buy some shirts and hot sauces from them, because they are awesome.
– I'm still working hard on my story Luna de Cuernos for 5th House Ensemble, and I wrote a blog entry here about the process so far.


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Äsphults församling var en församling i Villands och Gärds kontrakt i Lunds stift. Församlingen låg i Kristianstads kommun i Skåne län och ingick i Västra Vrams pastorat. Församlingen uppgick 2022 i Tollarps församling.

Administrativ historik
Församlingen har medeltida ursprung och var till 1962 i pastorat med Linderöds församling, före 1 oktober 1922 som moderförsamling, därefter som annexförsamling. Från 1962 till 1975 annexförsamling i pastoratet Träne, Djurröd och Äsphult. Från 1975 till 2006 annexförsamling i pastoratet Västra Vram, Östra Vram, Linderöd och Äasphult. Församlingen ingår sedan 2006 till 2022 i pastoratet Västra Vrams pastorat bestående av Västra och Östra Vrams församling, Linderöds församling och Äsphults församling. Församlingen uppgick 2022 i Tollarps församling.

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Pier House, Charlestown, St Austell, Cornwall, PL25 3NJ
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Pier House,
Explore Mid-Cornwall
Sorry we're closed
On 20th January a fire broke out at the Pier House, which has suffered significant damage as a result. Sadly, this means we are currently closed and will not be reopen again for a while.
Rest assured, St Austell Brewery's property team are working with local authorities - including planners and the parish council – as well as the Pier House team and local Charlestown residents, to reinstate this very special heritage building to its former glory as soon as possible.
We will miss you while we're closed. We'll keep you updated and look forward to seeing you again as soon as we can.
Our Managed Pubs, Inns & Hotels are part of St Austell Brewery Company Ltd and it adheres to the Company's Privacy Policy. To read the policy in full please follow this link.
Google will collect your personal data and use cookies for ad personalization and measurement when consent is given on this site. To find out more, please see Google's Privacy & Terms site.
This site is operated by St Austell Brewery Company Ltd which is a limited company registered in England and Wales.
All designs, text, graphics and the compilation (meaning the collection, arrangement and assembly) of all content on this site are owned by St Austell Brewery or its licensors unless indicated otherwise. Portions of this site may be electronically copied or printed for personal, non-commercial use. Any other use, including (without limitation) the reproduction, modification, distribution, transmission, re-publication, display or performance of the content on this site is strictly prohibited. No links to this site may be included in any other web site without St Austell Brewery's express written authorisation.
St Austell Brewery endeavors to ensure that the information on this site is correct but hereby excludes liability for loss or damage arising from any error or omission. In particular (but without limitation) the information given in this site is only intended as a general guide and should not be relied upon in place of specific advice.
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St Austell Brewery hereby excludes liability for loss or damage arising from any inability to access this site for any reason or any failure, error or delay in the sending or receiving of any notice or communication or instruction. These disclaimers shall not operate so as to exclude, limit or restrict St Austell Brewery's liability: for death or personal injury; for fraud or fraudulent misrepresentation; for damage suffered as a result of any breach by of the conditions as to title and quiet enjoyment implied by English law; under Part 1 of the Consumer Protection Act 1987; or for any other liability the exclusion or limitation of which is not permitted by English law.
These disclaimers do not affect the statutory rights of consumers. These disclaimers shall be governed by and construed in accordance with the law of England. If any provision shall be unlawful, void or for any reason unenforceable then that provision shall be deemed severable and shall not affect the validity and enforceability of the remaining provisions. All designs, text, graphics and the construction (meaning the collection, arrangement and assembly) of all content on this site are owned St Austell Brewery Limited or its licensors unless indicated otherwise. Portions of this site may be electronically copied or printed for personal, non-commercial use. Any other use, including (without limitation) the reproduction, modification, distribution, transmission, re-publication, display or performance of the content on this site is strictly prohibited.
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The Hullabalo Music and Camping Festival is one of Nebraska's most anticipated annual events, drawing over 1,500 eager festival-goers each year. The event was started in 2001 by the Kris Lager Band, a revivalist rock group based out of Omaha Nebraska, and touring for over a decade. The band began the event to bring the musical dynamism of touring artists to locals who were looking for a fully immersive festival experience. The event is a three-day affair each summer in Sokol Park. Nestled in untouched forestry, the park is a picturesque spot not only for music lovers, but also for diners, wedding parties and families looking for a great spot to spend their weekend days. For music-enthusiasts looking to enjoy the park after hours, there's a playground and recreation area, covered barbecue pits, horseshoe pits, basketball and volleyball courts and picnic tables.
Each year, the music stage comes alive with a strong lineup of local, regional and national bands, each riding the cusp of national fame; groups like Henry and the Invisibles, Battling Giants and the Brody Buster Band, and the event additionally attracts audiences with with its average ticket price of $25. Like the event's founding band, most performers are influenced by musical trailblazers like Jimi Hendrix, Taj Mahal, Johnny Cash and Led Zeppelin. Over the years, the festival has expanded to include vendors and various activities that give every type of festival-goer something to look forward to in between key performances. In the past, there's been hookah lounges, badminton courts, midnight movies and frisbee golf courses. A huge draw for most folks are the workshops and services available, like low-cost massages from local massage therapists, pottery and yoga classes and a variety of local vendors selling handmade jewelry, clothing and tons of eclectic art. For festival-goers, the music, supplemented by amazing local vendors makes the event stand out as one of the most immersive and enjoyable of Nebraska's yearly events.
The event isn't only a huge musical affair for natives and visitors to Bellevue, but also a great three-day getaway for camping enthusiasts. There are several rv parks in Bellevue, NE, some of which are clear favorites among yearly festival attendees. A 14-minute drive from Sokol Park, Haworth park is one of the event's most popular RVing spots. The Missouri River nearby is spectacular at sunset, and the camping spot itself a great place to relax after a full day of music and fun. Many visitors take advantage of RV parking at the Hullabaloo Music Festival to truly immerse themselves in Nebraska's spectacular natural landscape. Some go a little further to do some tent camping and hiking before heading off to the the festival, giving them an all-rounded taste of the beautiful scenery as well as the state's grand artistic domain.
The Hullabaloo Music and Camping Festival continues to be a Nebraska treasure, drawing huge, growing crowds of local creatives and excited campers and event-goers. We expect that 2017 will be an even more amazing year for the festival and hope to see you there!
Author Bio: Davina B. Adcock is the Content Manager/Data Team Manager and Marketing Specialist at RoverPass.com She is a storyteller by trade and enjoys travelling for work and pleasure.


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Q: How do I call a function after a jquery load I use jquery load to put a html structure in my body page. Afterwards, I want to call another function to display the table headers. It is suppose to run the function after the load. However, when I insert the completion function in the load parameters, the load is never complete. If I take it out, I don't get to call my function.
app.js
function insertHTML(){
  var thead = document.getElementByID("thead");
  thead.innerHTML = theadOutput(); //function works fine
}

window.onload = function(){
  $(body).load(body_loc, insertHTML());
}

A: You need to pass the function reference, instead of calling it:
$(body).load(body_loc, insertHTML);


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Q: Terminology, is this a mixed effects logistic regression? I have built this model in R and I am getting confused with the terminology.
For each individual ID I have a number of failures fail and successes success and one treatment.
mod1=glmer(cbind(fail,success)~treatment+(1|ID),family=binomial)

Is it correct to call this a mixed effects logistic regression?
Is it correct to say that this is a kind of GLMM?

A: Yes, you are correct that it is a generalised linear mixed effects model:
It is generalised because you have a non-continuous response variable and you are specifying a distribution family for it.
It is a linear model because it is linear in the parameters (because glmer fits linear models)
It is a mixed effects model because you have both a fixed effect (treatment) and a random effect (for ID).
It is also a logistic model because you specify binomial as the distribution family, and the link function in glmer when not specified explicitly is the canonical logit