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text:
The passing of a true British institution
Here's John Moran, Education demonstrator at the Planetarium paying tribute to Sir Patrick Moore: "Sir Patrick Alfred Caldwell Moore CBE, FRS, FRAS to give him his full title sadly passed away last week but he leaves behind a true legacy of not only astronomical knowledge but also of broadcasting over 50 years to which I am personally very grateful. The Sky at Night is the longest continuous show in British television history and is still going strong. For the last few years The Sky at Night has been broadcast from the home of Sir Patrick on account of his frail health but he never lost his enthusiasm or sharp mind for his subject. People often say to me how difficult it was to understand him as he spoke so fast and with the fervour of a true intellectual that they would often feel bamboozled, but his books, of which he has written dozens, are the complete opposite, with simple explanations on some hard to explain subjects. Patrick Moore was one of the main reasons behind igniting my love of astronomy and what made it even cooler in my mind is that he always considered himself to be an amateur. One of his biggest contributions in astronomy was advancing our understanding of the moon. He made some of the first finely detailed maps of the lunar surface which were consulted by NASA and the Apollo astronauts; this before the invention of amateur astrophotography and so was gained by hundreds of hours looking through his telescopes, and the notes and research are now an invaluable archive. It therefore seems somehow prophetic that he has passed away only two days after the 40th anniversary of the last manned mission to the moon, Apollo 17. Commander Eugene Cernan being the last man to step foot on the moon, something that Sir Patrick played a not insignificant part in. Easily one of the most recognisable voices on television he was also one of the most imitated; we all remember the famous Ronnie Barker sketch from the Two Ronnie's, or more recently John Culshaw, himself a keen astronomer and many times a guest on the Sky at Night, interviewing Patrick Moore as Patrick Moore. This showed also what a great sport he was. Sir Patrick was also a fierce campaigner for animal rights, a lifelong cricket enthusiast and accomplished musician; and as well as science fact he also wrote science fiction, truly a man of many talents. So in an age when people are lifted up to hero status far too easily for far too little, in my humble opinion Sir Patrick Moore will always stand out and be remembered as a truly inspirational British and global institution the likes of which we will never see again."

redpajama_set_name: RedPajamaCommonCrawl


text:
using System;
using System.Diagnostics;
using System.CodeDom.Compiler;
using System.Collections.Generic;
using System.Linq;
using System.Runtime.CompilerServices;
using System.Threading.Tasks;
using System.Web;
using System.Web.Hosting;
using System.Web.Mvc;
using System.Web.Mvc.Ajax;
using System.Web.Mvc.Html;
using System.Web.Routing;
using T4MVC;
namespace T4MVC
{
    public class PartialsController
    {

        static readonly ViewsClass s_views = new ViewsClass();
        [GeneratedCode("T4MVC", "2.0"), DebuggerNonUserCode]
        public ViewsClass Views { get { return s_views; } }
        [GeneratedCode("T4MVC", "2.0"), DebuggerNonUserCode]
        public class ViewsClass
        {
            static readonly _ViewNamesClass s_ViewNames = new _ViewNamesClass();
            public _ViewNamesClass ViewNames { get { return s_ViewNames; } }
            public class _ViewNamesClass
            {
            }
            static readonly _GridClass s_Grid = new _GridClass();
            public _GridClass Grid { get { return s_Grid; } }
            [GeneratedCode("T4MVC", "2.0"), DebuggerNonUserCode]
            public partial class _GridClass
            {
                static readonly _ViewNamesClass s_ViewNames = new _ViewNamesClass();
                public _ViewNamesClass ViewNames { get { return s_ViewNames; } }
                public class _ViewNamesClass
                {
                    public readonly string Bootstrap2 = "Bootstrap2";
                    public readonly string Bootstrap3 = "Bootstrap3";
                }
                public readonly string Bootstrap2 = "~/Views/Partials/Grid/Bootstrap2.cshtml";
                public readonly string Bootstrap3 = "~/Views/Partials/Grid/Bootstrap3.cshtml";
                static readonly _EditorsClass s_Editors = new _EditorsClass();
                public _EditorsClass Editors { get { return s_Editors; } }
                [GeneratedCode("T4MVC", "2.0"), DebuggerNonUserCode]
                public partial class _EditorsClass
                {
                    static readonly _ViewNamesClass s_ViewNames = new _ViewNamesClass();
                    public _ViewNamesClass ViewNames { get { return s_ViewNames; } }
                    public class _ViewNamesClass
                    {
                        public readonly string Base = "Base";
                        public readonly string Embed = "Embed";
                        public readonly string Macro = "Macro";
                        public readonly string Media = "Media";
                        public readonly string Rte = "Rte";
                        public readonly string Textstring = "Textstring";
                    }
                    public readonly string Base = "~/Views/Partials/Grid/Editors/Base.cshtml";
                    public readonly string Embed = "~/Views/Partials/Grid/Editors/Embed.cshtml";
                    public readonly string Macro = "~/Views/Partials/Grid/Editors/Macro.cshtml";
                    public readonly string Media = "~/Views/Partials/Grid/Editors/Media.cshtml";
                    public readonly string Rte = "~/Views/Partials/Grid/Editors/Rte.cshtml";
                    public readonly string Textstring = "~/Views/Partials/Grid/Editors/Textstring.cshtml";
                }
            }
        }
    }

}

#endregion T4MVC
#pragma warning restore 1591, 3008, 3009

redpajama_set_name: RedPajamaGithub


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A 3 bedroom, 3 bathroom Detached Finca located on the edge of the village of Benidoleig with stunning views and full of charm and character.
The property was re built in 2002 to a very high standard by a local builder and has a plot of almost 5000 sqms.
A few steps lead to the main entrance and the accommodation which is on two levels.
The ground floor accommodation comprises an entrance hall, dining room, lounge, American style kitchen, bedroom and bathroom. The lounge has patio doors which open onto a large terrace and swimming pool area and the main bedroom has a door opening onto another private terrace.
Stairs lead from the entrance hall to the first floor which comprises two further bedrooms, both with en suite bathrooms and balconies.
The property is in superb condition throughout with exposed stone and beams and much charm and character.
The plot extends to almost 5000 sqms and comprises gardens on several levels, with mature planting and trees, terracing and a private swimming pool. Steps lead down from this terrace to a garage below.
The vendors love ? ?The beautiful location, lovely views and the charm and character.?
We think ? ?This is a rare opportunity to acquire a Finca style property in such good condition and so close to amenities.?
Benidoleig is located in the Orba Valley only a fifteen minute drive from great sandy beaches. The village has a good selection of bars, restaurants, pharmacist and a supermarket. More comprehensive facilities are nearby in the village of Orba.
The busy port town of Denia is only a twenty minute drive away with the Motorway exit and Ondara Shopping centre only ten minutes away.


Tony Goldstein, Managing Director of South East Enterprise was awarded the prestigious Trainer of the Year award at the recent National Enterprise Network annual conference and awards ceremony held at the British Library in London on 15 November 2013. The award was presented by Rebecca McNeil Head of Business Lending at Barclays who sponsor the successful Get Ready for Business series for individuals considering starting a business.
Rebecca said:'This award was introduced last year to recognise trainers of the Barclays Get Ready for Business seminars that have gone above and beyond to ensure delegates get the very best from the training and who have built great relationships with their local Barclays team'.
'Tony has been providing business support in Lewisham for many years and is still always willing to go the extra mile for clients. He has built a good relationship with the local Barclays team who agree that he is very professional and engaging, interacting with attendees and giving great advice from his own wealth of business experience'.
South East Enterprise has been delivering Get Ready seminars for many years where delegates learn the essential facts about starting a business and are able to make an informed decision about whether business is for them.


The offices are fully lit, carpeted and heated and the warehouse is heated by a gas-fired blow heater.
The property occupies a site on the west side of Kirkhill Drive within the Kirkhill Industrial Estate which is situated 7 miles north west of Aberdeen City Centre.
Major occupiers established within the estate include Baker Hughes, Weatherford, Expro and Aker.
Aberdeen is Scotland's third city with a population in the region of 228,000, a total catchment of 500,000 and is one of the most prosperous regions in the UK.
All main services are installed. Heating to the offices is a mixture of gas radiator central heating and electric panels. Warehouse 1 is served by a gas fired industrial blower.
Warehouse and ground floor offices: £99,000.
The uniform business rate for the year 2018 / 2019 is 48.4p in the £ for a rateable value under £35,000 and 51.0p in the £ for a rateable value over £35,000.
These rateable values are currently under appeal.
The property is available on the usual full repairing and insuring terms for a period to be negotiated.


SUNNYVALE, Calif. and ALBUQUERQUE, N.M., Aug. 10, 2017 /PRNewswire/ -- RiskSense®, Inc., the pioneer and market leader in pro-active cyber risk management, today announced the appointment of Danny Quist as the company's first CTO. Quist was most recently head of security operations and engineering for Bechtel Corporation, the United States' largest construction and civil engineering company. He is also a leading expert in malware reverse engineering who has worked with MIT Lincoln Laboratory and Los Alamos National Laboratory.
"Danny Quist is one of the most respected IT security and malware analysis experts in the industry, hiring him as RiskSense's first CTO is a major coup," said Dr. Srinivas Mukkamala, co-founder and CEO of RiskSense. "His deep understanding of both security operations and exploit code will play a major role in helping expand our platform's attack surface validation capabilities deeper into critical infrastructure, industrial control systems, IoT, automotive and more."
Quist joined RiskSense from Bechtel Corporation, where he managed the company's global cyber security including its computer incident response teams and security operations center. He has served as a security researcher on malware reverse engineering and kernel development with MIT Lincoln Lab, Los Alamos National Laboratory and was founder and CEO of software and network security penetration testing firm Offensive Computing LLC. His insights on malware analysis have a large industry following @OpenMalware.
"RiskSense has developed a powerful platform that combines penetration testing, vulnerability assessment and risk scoring to provide organizations with unprecedented visibility into their attack surface and security exposures," said Danny Quist. "Joining this world-class team of cyber security researchers and professionals was too good of an opportunity to pass up. We have the potential to become the industry's next major security vendor."


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text:
Stephen Hawking Mad Lib
Stephen Hawking is generally considered to be one of the greatest physicists of our time. He is often compared to great historical physicists like Albert Einstein and Sir Isaac Newton, though he denies he belongs in such a prestigious group.
To complete the Hawking Mad Lib below, first, print out a copy of this post by going to File -> Print in your browser menu. (Or copy and paste the contents into a Word document and print from there.) Then, fill in the blanks at the top of the post with the appropriate parts of speech. Next, fill in the numbered blanks in the story with the words from the list at the top. Read out loud with friends and enjoy!
1. Adjective _______________
2. Unit of Time, Plural _______________
3. First Name _______________
5. Verb _______________
6. Plural Noun _______________
10. Verb _______________
11. Adjective _______________
12. Noun _______________
13. Type of Container _______________
16. Past Tense Action Verb _______________
20. Name of Person _______________
Stephen Hawking is a (1) _______________ British physicist who helped flesh out the Big Bang theory and explain the anatomy of a black hole. He was born on Jan. 8, 1942 - exactly 300 (2) _______________ after the death of Galileo. Hawking is a relative cosmologist - a person who studies the Universe using (3) _______________ Einstein's (4) _______________ theory of relativity.
In 1962, just before starting graduate school at the University of Cambridge, Hawking discovered he had an incurable and fatal disease called amyotrophic lateral sclerosis or ALS, also known as Lou Gehrig's disease. Doctors gave him only two years to (5) _______________. But Hawking overcame the odds, earned his PhD, got married, started a family and rose to fame as one of the greatest (6) _______________ of our time.
One of Hawking's most (7) _______________ theories is that black holes aren't really black. Hawking predicted that black holes emit radiation, challenging the (8) _______________ idea that nothing could escape the gravitational pull of a black hole. Thanks to Hawking Radiation (named for the man who predicted its existence), physicists now believe that black (9) _______________ will eventually radiate away all of their mass and disappear.
Despite not having the ability to speak or (10) _______________, Hawking is a (11) _______________ author who has published a handful of books like A Brief History of (12) _______________ and The Universe in a (13) _______________.
Hawking retired as the Lucasian Professor of Mathematics at Cambridge in 2009. He has twelve honorary degrees and was awarded the (14) _______________ Medal of Freedom - the United State's (15) _______________ honor - by U.S. President Barack Obama that same year.
In 2007, Hawking became the first quadriplegic to experience zero-gravity when he (16) _______________ in a Vomit Comet. When asked why he went on the (17) _______________, Hawking said that he wanted to encourage public interest in space and also that he was training to (18) _______________ to space on a Virgin Galactic suborbital flight.
Though he is interested in riding into space, Hawking's take on manned space exploration can be a little (19) _______________. In 2004, a New York Times Magazine interviewer named (20) _______________ asked Hawking, "What do you think of President Bush's plan to get [humans] to Mars in 10 years?"
Hawking's answer: "Stupid. Robots would do a better job and be much cheaper because you don't have to bring them back."
To learn more about Stephen Hawking, visit his website.
For more Physics Buzz Mad Lib fun, check out our Tesla Mad Lib!
Space Tourism May 9, 2011 at 10:31 PM
I have read about his interesting views of the Space tourism and Virgin Galactic. I think its great that space travel has become cheap to a extend that a good chunk of people can afford traveling to space.


text:
Q: Typescript: can alias one module at a higher level in the tree, but not another? I have setup the following module structure:
module A.B.C.D {
  var ajaxLibNS = ajaxLibNS || A.B.1;
  var appUtilNS = appUtilNS || A.B.2;
  var appUtil = appUtil || new appUtilNS.AppUtil(); //a class that may be found in module A.B.2

  export class SomeClass implements ISomeInterface {
    //region properties
    private ajaxResponse: ajaxLibNS.IAjaxResponse;
  }
}

When I compile, the compiler complains, "error TS2095: Could not find symbol 'ajaxLibNS'"
I don't understand why the compiler does not similarly complain about appUtilNS, as it exists at a similar location (i.e., "two levels up, and one over") in the module hierarchy. Yet, there is no complaint from the compiler and the code where appUtil is created runs just fine.
Can someone illuminate me, please? Thanks!

A: Here's a simplified version of what you're seeing:
module A {
    export class Foo {}
}

module B1 {
    var f = A.Foo;
    var x = new f(); // OK
    var y: f; // Error, can't find symbol f
}

The issue is that in this example, f only exists in the value namespace. TypeScript has two different kinds of names: types and values. When you write a type annotation, you're looking up in the type namespace; in an expression context, you're looking up in the value namespace. var declarations do not contribute to the type namespace.
import declarations, though, contribute both meanings of the imported name. So, you can write this instead:
module B2 {
    import f = A.Foo; // Change 'var' to 'import'
    var x = new f(); // OK
    var y: f; // OK
}

Note that the generated code here is identical; this just gets the type name of A.Foo into f.

redpajama_set_name: RedPajamaStackExchange


If everyone bred like the Octomom, the population would double every 11 years!* In less than 50 years, then, the population would be 16 times the current bloated level. And you think your ride to work is congested now?
After months of investigation, the Los Angeles County District Attorney's Office has charged Nadya Suleman, aka Octomom, with three counts of felony welfare fraud, reports TMZ.
Full Segment: TMZ reports that an unnamed person complained to WFP&I claiming Octomom Nadya Suleman is collecting welfare benefits even though she made close to $200,000 last year.
TMZ reports that an unnamed person complained to WFP&I claiming Octomom Nadya Suleman is collecting welfare benefits even though she made close to $200,000 last year. Joining to discuss is HuffPost Celebrity Editor Erin Clements.


Enter Square Feet min. 19.8 sq. ft.
Total Sq. Ft. : 19.8 sq. ft.
Price : $2.99 sq. ft.
Colonial Oak is a traditional engineered red oak from Shaw. These planks have a distinct visual range from ones with extreme graining and color variation to those with a clean and consistent look. Colonial Oak is part of Shaw's EPIC hardwood collection. This hardwood is made with EnviroCore, which is Shaw's high-density core board made from recycled post-industrial wood fiber.


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Calum Chambers looks set to play a part in Unai Emery's Arsenal revolution after signing a new four-year contract at the Emirates.
Often on the periphery of the team, the appointment of the Spaniard could just be what the 23-year-old needs as he finally looks to nail down a regular place in Arsenal's team.
Despite signing a new two-year contract last October, it looked like Chambers could be one of the players sold this summer to raise vital funds for Arsene Wenger's replacement.
It was reported at the start of June that Fulham wanted to entice the centre-back across the capital, yet Slavisa Jokanovic's team are now going to have to look elsewhere to strengthen at the back.
Amid question marks over his long-term future at the Emirates, the ex-Southampton man now has the chance to prove why he was brought to the club for £16million in 2014.
Chambers has only made 48 appearances for the Gunners in the Premier League in his four years with the club, with nearly half of those coming in his first campaign.
The player only made 12 league appearances in Wenger's final season in N5, yet Emery clearly sees something that he can work with over the next few seasons.
The likes of David Villa, Juan Mata, Ivan Rakitic and Presnel Kimpembe all improved under the guidance of the 46-year-old, and Arsenal fans will be hoping the new man in charge can work his magic once again in the capital.
Having already added at the back with the signing of experienced defender Stephan Lichtsteiner from Juventus, more arrivals are expected to follow over the coming weeks.
Sokratis Papastathopoulos is now officially an Arsenal player after completing his move from Borussia Dortmund, while Caglar Soyuncu could be another potential arrival with Sven Mislintat very keen on luring the Freiburg man to the Emirates.
Opportunities will once again be hard to come by for Chambers, thus making it imperative he takes them and makes an instant impression under Emery.
The defender impressed towards the end of last season when given the chance, notably in the second leg of the Europa League semi-final when he came up against Antoine Griezmann and Diego Costa in the 1-0 defeat at Atletico Madrid.
Laurent Koscielny's long-term injury, as well as Shkodran Mustafi's form, could present him with a chance ahead of the opener against Man City on the opening weekend, although Konstantinos Mavropanos and Rob Holding will also fancy their chances of winning a starting spot.
Whether or not he does indeed start against the Premier League champions in August, Emery has revealed that opportunities will be there for the club's youngsters.
"In terms of young players, it's important to give them the opportunities that they deserve," Emery told Standard Sport. "And when they earn those opportunities, they also earn the respect of their teammates.
"I've never seen anything handed out for free in football and in terms of Arsenal and their history, the young players have always earned those opportunities.
"I'm not going to be closing the door to anyone, so I'll be giving young players just the opportunities that they deserve."
Mavropanos is the young player expected to take his game to the next level under Emery having caught the eye in his his three appearances for the club last season.
The defender is definitely in the manager's thinking for next campaign, especially with some fans spotting in a video of Emery's first day at the club that Ivan Gazidis pointed to a photo of Mavropanos and specified to the Spaniard that they'd already spoken about him.
French football expert Julain Laurens also mentioned in an interview on BBC Five Live prior to Emery's appointment that the Greek centre-back would be the one to thrive under the new boss.
"Unai Emery is a coach. He will improve players. He doesn't need to have superstars who cost €100million," said Laurens.
"His job, and the best job he did at Sevilla, was to take those players that Monchi was finding in lower leagues in France and obscure leagues in Europe and make them play as a team and win trophies.
"There's a rebuilding job at Arsenal. You need someone who can work on the training pitch to improve the players you have because there may not be the money to sign 10 to 15 players in the summer. Then he's the right guy for that.
"I think he's going to work well with Sven Mislintat who found [Konstantinos] Mavropanos and Mavropanos is going to blossom under Unai Emery. There's no doubt about that!"
With many expecting Mavropanos to be the youngster to be given a chance for Arsenal under Emery, Chambers may well be the one to shock a few and make a name for himself in the team.
Following four years at the Emirates, the defender needs to take his chance sooner rather than later if he is to become a hit for the Gunners.
This new deal could be the making of Chambers.
ArsenalThe astonishing Arsenal statistic that Unai Emery must rectify for next seasonThe Gunners have lost their last two games, conceding six goals.


text:
OMG! Take a look at your reputation flavor text! Mine is: Water Bottle on Sam's Mountain Bike.
Distracted by Olympic soccer but I'm here. I may even have a little ficlet to share sometime after the post-a-thon.
30-minutes until 'Conversion' and I'm very exited.
SGA – Sparky fanvideo
S-minus 25 minutes to Conversion!
Looking forward to reading it!
Originally posted by ShWeir View Post
The Air Training Corps (Pronounced like core). This should explain;
http://www.raf.mod.uk/aircadets/
Thanks, ShWeir!! Oddly enough our conversation gave me an idea for a fic I hope to have finished before I go to bed tonight. It's set not long after The Storm/Eye and John decides Elizabeth needs to learn how to shoot. Just in case.
Where do you find that?
Scroll over your rep points, SR. You're officiating a boxing match between SG1 Weir and SGA Weir.
Once again I win. I am Zelenka's swim coach.
Same here. *High fives*
Curse you.
Got it. Why are you all so much smarter than I am? Never mind.
Nope, I win this time. I hate the water and can't swim. Little known fact about me. I say Lizzeh can take her.
Hmm, Lizzeh vs. Lizzeh. Who to root for?
Lizzeh.
*High fives*
How can you be an East Coast girl and not swim?
Torri Weir would mop the floor with Jessica Weir.
S-minus 15 minutes and counting.
Indeed and that brings up something I want to throw out there before we watch it. When the original airing was coming up, Sci Fi ran an ad showing John sitting on his bed and someone whose face was hidden standing beside him. We argued back and forth on who this could be. I said it couldn't be Elizabeth because I just didn't think they would go there. Happily, I was very wrong. At this same time there was the TV Guide cover with John and Teyla and a big buildup about how their relationship was about to change. We all braced ourselves for full out Sheyla, but lo and behold, at least IMHO, we got the death of that ship instead. Big surprises all around. And needless to say the way they showed John and Lizzeh so close in this ep fueled many a Sparky fire. Once again TPTB told us one thing and showed us another. And they wonder why Sparky exists.
More proof that you missed a lot of fun stuff when you weren't around when the episode first aired but at the same time I don't know what all those intense stuff would have done to me at the time.
Originally posted by TheLadyMore View Post
TV guide usually care more about the outright intense scenes like that. If someone kisses someone it was like oh-la-la. It was like the whole thing where they thought John was Torren's father, but of course we find out it's Kaanan's kid.
Its true there was a tiny microscopic Sheyla but it was more like OH AM IZ A BUGZ NOWZ IMZ GONNAZ KISS TEYLAZ, while Sparky there were many intense scenes in the episode, John punching the glass wall in Elizabeth's office, John screaming at Elizabeth and grabbing her by the neck and slamming her against the wall (I think John was freaking out after that cause the guy who moves heaven and hell to protect her is hurting her). Of course the biggest scene in my opinion was John and Elizabeth with Bug!John in the robe walking together to go on the mission. It says alot, you know he was dangerous but she was not afraid to support him.
I loved that scene (even had it in my video) and it does say a lot that she not only walked with him the whole way but also the way that she couldn't walk closer to him if she tried indicate that she is always there for him and supports him.
Definitely proves the saying, "Actions speak louder than words," doesn't it? *snickers*
When it comes to Sparky it sure does and I prefer it that way.
And don't forget "it's better for the both of us". We're still not sure what he meant by that. All that just proves that they told us one thing and showed us another. TV Guide was clueless.
That line always made me curies, I mean shouldn't it have been "It's better for all of us" if he hadn't meant for it to be something personal for the two of them. It's also the part where he says "I'm not safe to be around anymore" and while that isn't so much time line itself but it's more in the way he says it.


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Home 2013, 2018, Mayor and Council, MinutesMayor and Council Meeting Minutes – August 6, 2018
Mayor and Council Meeting Minutes – August 6, 2018
August 21, 2018| 2013, 2018, Mayor and Council, Minutes| jmulligan
Mayor Cerino called the meeting to order at 7:45 p.m. In attendance were Councilmembers David Foster, Linda C. Kuiper, Ellsworth Tolliver and Marty Stetson, W. S. Ingersoll (Town Manager), Jennifer Mulligan (Town Clerk) and guests.
Mayor Cerino asked if there were any additions or corrections to the minutes of the Mayor and Council Meeting of July 16, 2018. Mr. Foster moved to approve the minutes of the Mayor and Council meeting of July 16, 2018, was seconded by Ms. Kuiper and carried unanimously.
Mayor Cerino stated that total operating cash on hand for unrestricted use is $218,148.00. A total of $61,851.92 in bills has been paid for construction work at the Marina which the Town was waiting to be reimbursed through grants, bringing the total to $280,000.46. Private Donations received for the Marina project were $865,034.63 with a balance of $333,608.57 which will be used for one to one matches as the Marina project progresses.
Mr. Stetson stated that the he was unhappy to see funds so low. Mayor Cerino agreed, stating that he was concerned the Town would not be able to fund payroll. Mr. Ingersoll stated that early checks for real estate taxes will come in sometime in mid-August, noting that last August the Town received $125,000.00. Mr. Ingersoll stated that payroll is approximately $80,000.00 and will certainly be met. He said the largest amounts of revenue for the Town are received in September and October and the accounts will stabilize. A line of credit is available if necessary. Mr. Stetson asked if the Town could borrow funds from the Utilities Commission. Mr. Ingersoll stated that has been done in the distant (1970's) past but the auditor at the time asked that funds not be transferred from one entity to the other.
Mr. Ingersoll stated that there was a TEFRA Bond hearing before the meeting regarding Resolution 03-2018 Town of Chestertown Bond Issuance on behalf of Heron Point. He asked Lindsey Rader, Esq. (the Town's bond counsel) to explain the need for the resolution.
Ms. Rader stated that Heron Point pays all the fees for the transaction and the Resolution indicates that the bond transfer will take place before December 31, 2018. Ms. Rader stated that she is paid by Heron Point to represent the Town as their legal bond counsel. The Town is indemnified from responsibility on this debt. Ms. Rader stated that the bond issue was not to exceed $26,500,000.00 and the Resolution authorized the Mayor or Town Manager to sign the documents and bonds moving forward.
Ms. Rader stated that this bond issue was a refinance of the 2013 TEFRA bond issue. She said that the 2013 refinance included refinancing of the current structures and new construction at Heron Point.
Mr. Stetson stated that the Town acted as a conduit issuer for Washington College in the past and once received a fee for doing so. Ms. Rader stated that in her experience with these types of bonds, issuer's fees to a municipality are not the normally charged, although she has heard of fees for financing outside of a jurisdiction.
Mayor Cerino stated that the Town did just raise taxes, which Heron Point residents pay, and although Mr. Stetson raised a good point for having a fee, he did not think that this was the time to initiate one. He said that fees could be discussed before any paperwork is finished in future requests. Mr. Foster agreed, stating that a policy should be put in place if the town expects a fee in future conduit bond issuances.
Mr. Ingersoll stated that this bond issue is at no cost to the Town and it was something the Town could do to be a good neighbor. He said that Heron Point could go to the Kent County Commissioners to have them act as a conduit and they would gladly do it for the good will.
Mr. Foster moved to support Resolution 03-2018 Town of Chestertown Bond Issuance on behalf of Heron Point, with the understanding that Chestertown will establish a policy in the future for bond issue fees, was seconded by Rev. Tolliver and carried unanimously.
Mr. Ingersoll stated that the Town of Chestertown submitted a BUILD grant to the federal government for road improvements for 13.4 miles of road. The grant request also included safety features, signage, crosswalks, pavement markings, handicap ramps and storm drain improvements from High Street to the south end of Cross Street. Mr. Ingersoll stated that the total grant request was for $4.5 million. Mr. Ingersoll stated that he wanted to thank Ms. Linda Kohler of Chesapeake Charities who aided the Town in writing the grant and secured support letters from the entire Delegation to accompany the request. He said that Mr. Dick Goodall of Dixon Valve was instrumental in enlisting Chesapeake Charities' services to help with the grant writing.
Mr. Ingersoll stated that he was optimistic about the BUILD Grant. He said it was the first ever round of funding and not all jurisdictions were aware enough to apply. Mr. Ingersoll stated that the Town will be competing with other municipalities and counties in the State and around the Country for grant funding.
Mr. Foster stated that the Maryland Municipal League Bulletin has information in reference to water and sewer funds available for different projects. He said that he will forward the information to Mr. Ingersoll and Mr. Sipes.
Mr. Ingersoll stated that he had a request for an Overdose Awareness Day Candlelight Vigil in the Fountain Park on Friday, August 31st from 7 p.m. to 9 p.m. Ms. Rani Gutting is the contact for the event and is requesting a temporary memorial, either luminaries or an artificial tree to hang photos of those lost to opioids.
Mayor Cerino asked Chief Baker to give an update the shooting that took place over the weekend. Chief Baker stated that there were two non-life threatening injuries at approximately 1:00 a.m. on Sunday morning at the intersection of Calvert and Lynchburg Streets. He said that this was an intentional shooting and it was an ongoing investigation.
Mayor Cerino stated that the residents should take a look at the progress at the Marina. He said that the docks are coming along and the last retaining wall was just poured. He said that in a short time the grade will be raised.
Mayor Cerino asked for ward reports.
Mr. Foster stated that he attended a radio broadcast at Sumner Hall on Tuesday, July 31st where there were several interviews with a broad spectrum of topics discussed.
Mr. Foster stated that he attended a Save the Hospital meeting on Thursday, August 2nd in Town Hall and that Ms. Margie Elsberg has a good piece on the Chestertown Spy about the Hospital. Mr. Foster stated that UMMS Regional Health and Save the Hospital both agree that the hospital should remain open. He said that whether or not to keep an intensive care unit was still an issue and the hospital would go down to 15 beds. Mr. Ken Kozel was present at the meeting and said that he wanted to dispel rumors the hospital was closing and if misinformation was being given to the public he would take action to correct the matter.
Mr. Kuiper stated that UMMS is committing the $7 million in funding raised from the sale of their nursing home on Morgnec Road to health related services in Chestertown through the foundation.
Ms. Kuiper stated that she attended a ribbon cutting for Movement Mortgage at 205 South Cross Street on Friday, August 3rd at noon.
Ms. Kuiper stated that she attended a funeral for the Farmers Market Manager, Owen McCoy, on Saturday. She said that Mr. McCoy's daughters, Danya Benton and Kailee McCoy, would like to manage the market in their Father's stead. Ms. Kuiper stated that Ms. Benton and Ms. McCoy did manage the market after Mr. McCoy took ill. Mr. Foster moved that Ms. Danya Benton and Ms. Kailee McCoy manage the Farmers Market to the end of the calendar year and split the fee received by the Market Manager, was seconded by Rev. Tolliver and carried unanimously.
Ms. Kuiper asked if there was any news from Chesapeake Movies on when the theatre will open. Mr. Ingersoll stated that he visited the theatre last week and was disappointed with the progress. He said that he sent an email to Michael Klein who told him that the HVAC was still not replaced by the owner of Washington Square Shopping Center. Ms. Macintosh stated that she was hoping to meet with Mr. Klein this week to see the theatre and to ask for a new timeline with an opening date. Mayor Cerino asked if the County has made the loan yet to the theatre owners. Ms. Macintosh stated that she would inquire as to whether or not the loan transaction took place. The Mayor said that this was a disappointing delay and he was starting to wonder about the project.
Rev. Tolliver stated that he wanted to congratulate Chestertown Garage as they finished their changeover to NAPA. He said that the building looked nice with the new signage and painting.
Rev. Tolliver stated that the Seed House was expanding their business to include delivery service. Germaine's was going to expand their business hours into the evening.
Rev. Tolliver stated that he has received some complaints from residents of Coventry Farms that trash is not being picked up when it is supposed to be and sometimes it was missed altogether.
Rev. Tolliver stated that Washington Park Day would be held on Saturday, August 11th. He asked who he could contact to see about spraying for mosquitos. Mr. Ingersoll stated that the State and County control the spraying so he should check with them to see if there a schedule.
Rev. Tolliver stated that this was the 5th Annual Legacy Day and he would like to have a proclamation from the Mayor and Council in celebration. He also said that there will be a celebration remembering Wade Brown on Calvert Street that same day.
Rev. Tolliver stated that he was concerned over the incident that took place at Calvert and Lynchburg Streets over the weekend. He encouraged residents to find more productive ways to solve conflict.
Rev. Tolliver reminded residents that it was their responsibility to keep their lawns mown and to clear brush and clean up trash.
Mr. Stetson stated that he met with Amy Meeks of the Recreation Commission and Tom Sappington of the Street crew to lay out the placement of the new playground equipment Bailey Park. He said that he also ordered metal signs for the Dog Park. He said that he had laminated signs in the past but they needed to be replaced too often.
Mr. Stetson stated that August's First Friday was a great time until the rains came and Saturday's Music in the Park was also great.
Mr. Stetson stated that he was having a hard time with the billing department at Atlantic Broadband, spending long times on hold and not receiving callbacks or return emails. He said that he hoped to see an improvement in their customer service.
Mayor Cerino stated that Ms. Connie Hickman had asked to address discuss homeless issues in Chestertown. Ms. Hickman asked if the Mayor and Council could do anything to help with this problem in Chestertown as many people are sleeping on the streets. Ms. Hickman stated that the she had an apartment at Chestertown Landing but was evicted when her brother, who is homeless and has cancer, was found to be staying with her.
Mayor Cerino stated that the Town supports the Samaritan Group which does have a shelter but is only open during winter months. Ms. Hickman stated that all of the housing projects in the area have a waiting list and there were several people who were completely homeless waiting to find a place to live. Ms. Hickman stated that she is a disabled widow receiving social security disability and only has about $750.00 per month.
Ms. Kuiper asked if Ms. Hickman has been to Kent County Social Services. Ms. Hickman stated that she has been but they are not much help. She said that she has a HUD voucher but does not know if she will be chosen for housing or not. Mr. Ingersoll stated that the Town has participated in the building or sponsoring of many low income housing projects in Town, but the Town did not oversee the day to day activities of those housing developments. Ms. Hickman stated that the waiting lists seem to be long and the best that Social Services will do is to put them up in a hotel for a night.
Mayor Cerino asked if there were any questions or comments from the audience.
Ms. Emily Moseman, resident of the 400 block of High Street, stated that the house on the corner of High Street and South Kent Street is again becoming a hangout for people and she thought that there were drug deals taking place. She said that the apartment building is mostly rented to college students who are not in residence during the summer months and the people hanging out there are not visiting anyone in the apartment building. Ms. Moseman said that she called the police but they can't really do anything to help without making a formal complaint. Mr. Ingersoll stated that he will contact the owner of the building because if the owner is making the complaint the police will be able to help. Mr. Ingersoll stated that this problem may solve itself once the students return for the fall semester.
There being no further business and no other questions or comments from the audience, Mr. Stetson moved to adjourn the meeting at 9:10 p.m., was seconded by Rev. Tolliver and carried unanimously.
Last modified: October 27, 2019


The purpose of this study was to investigate the performance of grade10 students in mathematics tests and identify the major causing factors that influence students' achievement in mathematics. A correlation research design was employed. 10 secondary schools were sampled by purposive sampling technique. 21 sections (1378 students) of 10th grade students studying in the academic year 2014/15 and 40 mathematics teachers were sampled by Systematic sampling technique in the sampled schools. The study was carried out by employing close-ended questionnaires addressing issues attributing to mathematics achievement like gender stereotype, attitude, demographic factors, instructional factors, individual factors, students' mathematics semester average and grade letter of Ethiopian General Education Certificate Mathematics Examination (EGSECME). These variables were analyzed statistically with t-test and correlation analysis using version 20 SPSS-PC software package. The results of the study indicated that there is statistically significant differences between male and female students in mathematics achievement in EGSECME grade letter; and male students significantly performed better than female students. Moreover, the analysis of close-ended questions showed Demographic Factors, Instructional Factors, and Individual Factors are the causing factors that attribute to students' low mathematics achievement.


A family bereavement has meant that I've not been able to post much lately but here are two mobile phone photos of a chilly Llandudno today. It was actually a lovely day for a walk, as long as you were wrapped up properly.
my grandfather was baptised there and we would love to see it short of being there.
Sorry to hear about the bereavement.


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Why distance learning hurts schools' budgets
Lisa Irish | AZEdNews
Many Arizona school districts returned to distance learning after winter break as COVID-19 cases surge, but doing so hurts their budgets, because the state funds distance learners at five percent less than in-person students.
Chuck Essigs
That is just one of many considerations school leaders and governing board members weigh when deciding whether to change instruction models as Chandler and Gilbert Unified School Districts did on Monday two days after Gov. Doug Ducey declined Supt. of Public Instruction Kathy Hoffman request for him to order schools to provide distance learning for two weeks following winter break.
Arizona's district and charter schools have $266 million less in state funding because distance learners are funded less than in-person students, the Arizona Department of Education said in its Fiscal Year 2021 Distance Learning Adjustments to the Base Support Level report released a day before most schools closed for winter break.
It is my sincere hope that the #AZLeg will work together in bipartisan fashion to fix this critical issue 🙏🏼@michudall @PaulDBoyer @reginaldbolding @Rios_Rebecca https://t.co/3UrKvDCYLi
— Beth Lewis 🆘🏜🎓 (@AZBethLewis) January 10, 2021
Reduced funding for distance learning means many Arizona school districts have thousands to millions less in state funding than they budgeted for, putting them in a difficult financial situation, said Chuck Essigs, director of governmental relations for Arizona Association of School Business Officials.
The state could have avoided this situation by funding in-person and distance learning at the same rate, Essigs said.
Infographic by Lisa Irish/AZEdNews
Click here for a larger version
The argument for lower funding for Arizona Online Instruction "is that it costs less to provide those programs, because you don't have to provide brick and mortar space for those students, you don't have to provide any outside services and one teacher can serve a fairly large number of students," Essigs said.
But unlike Arizona Online Instruction students, schools must still have space, enough teachers, and provide other services for distance learning students, because they will be back on campus when COVID-19 health metrics improve, Essigs said.
Declining enrollment raises financial pressure on schools
Another factor reducing schools' state funding is declining enrollment with 50,000 less students enrolled statewide.
"A good example is for kindergarten students, we're down more than 10 percent," Essigs said. "What we believe is happening is some parents are saying, 'I'm not going to send my student to kindergarten this year, I'm going to wait until next year.'"
"If you were a district that lost five percent of your students to declining enrollment and lost another five percent in funding because of the distance learning program, you're operating with 10 percent less dollars than you would have normally had and you're still providing services," Essigs said.
"Districts are having a really difficult time financially, because of the loss of students, but in addition that five percent loss of funding when students are in distance learning," Essigs said.
Thirteen of 207 Arizona school districts were found to be at higher financial risk than others based on the analysis of 10 measures in the School District Financial Risk Analysis released in December 2020 by the Office of the Arizona Auditor General in an effort to alert school district leaders to make changes to avoid financial issues.
A slide from the School District Financial Risk Analysis released in December 2020 by the Office of the Arizona Auditor General.
All these school districts had a change in their weighted student count which impacts their state funding through per-pupil base funding, and most are small districts in rural or remote areas of Arizona, with the exception of Tucson Unified, Apache Junction Unified, Isaac Elementary and Murphy Elementary.
In an effort to make up some of the five percent in state funding lost for distance learning, Gov. Ducey allocated $370 million in federal CARES Act money for Enrollment Stabilization Grants in June. At the time, Gov. Ducey said schools would not lose more than two percent of the state funding they had received the previous year, but that has not been the case for many schools.
What lower than expected Enrollment Stabilization Grant funding means for schools
Requests for the Enrollment Stabilization Grants were more than the funds allocated so the amounts schools received were reduced. School leaders thought that more money would be added to the grant program if needed, but that did not happen.
"Based on the allocations provided to schools last week, the state has not kept the promises made this summer," said Superintendent of Public Instruction Kathy Hoffman in a statement. "I am ready to work with the Governor and education stakeholders, and the Legislature to ensure that we uphold our responsibility to Arizona's schools."
Education advocates are hoping that the Arizona Legislature will realize that school districts reduced funding due to declining enrollment and the distance learning formula has saved "the state general fund a very large amount, because they're not funding schools for those students," Essigs said.
"We would hope that the state would realize that the additional burden on schools is a real problem, the Enrollment Stability Grant is way underfunded in terms of what districts need, and that they will use some of the savings that the state is experiencing to help school districts with the struggles that they're facing," Essigs said.
Federal dollars from the CARES Act program are helping school districts with some of the additional expenses they have incurred to help prevent the spread of COVID-19, such as special cleaning, plexiglass shields, and other measures, Essigs said.
"Plus, with students doing distance learning there's a big additional cost of providing the equipment to provide services online," Essigs said.
The Arizona Legislature needs to recognize that these costs when combined with reduced state funding are hurting school districts' budgets, Essigs said.
There is some assistance coming for schools in the second round of Elementary and Secondary School Emergency Relief Fund II as part of the Coronavirus Response and Relief Supplemental Appropriations Act of 2021 recently passed by Congress.
Arizona funding under ESSER II is estimated at $1,149,715,947, which is about four times what was received under the first round of CARES ACT funding, Essigs said yesterday.
ESSER II Fact sheet page 1. Courtesy of Arizona Association of School Business Officials
"The new funding is available for an extended period of time and has a distribution formula very similar to the earlier program," Essigs said.
For a detailed analysis of Arizona's allocation from the ESSER II funding please see this breakdown on Congressional action related to COVID-19 Relief and how it will effect K-12 public schools that was prepared by Arizona School Boards Association's Governmental Relations team.
Page 1 of an analysis of Congressional action related to COVID-19 Relief and how it will effect K-12 public schools by Arizona School Boards Association's Governmental Relations team.
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text:
v. 40 n. 3 e 4 (2014) /
Artigos de Revisão da Literatura
Nutrigenômica/nutrigenética na elucidação das doenças crônicas
Maria Anete Santana Valente Universidade Federal de Juiz de Fora – campus Governador Valadares Av. Dr. Raimundo Monteiro Rezende, 330 – Centro- Governador Valadares - MG CEP: 35010-177
Maria Cristina de Albuquerque Barbosa Universidade Federal de Juiz de Fora – campus Governador Valadares Av. Dr. Raimundo Monteiro Rezende, 330 – Centro- Governador Valadares - MG CEP: 35010-177
Cibele Velloso Rodrigues Universidade Federal de Juiz de Fora – campus Governador Valadares Av. Dr. Raimundo Monteiro Rezende, 330 – Centro- Governador Valadares - MG CEP: 35010-177
Patrícia Aparecida Fontes Vieira Universidade Federal de Juiz de Fora – campus Governador Valadares Av. Dr. Raimundo Monteiro Rezende, 330 – Centro- Governador Valadares - MG CEP: 35010-177
Meire de Oliveira Barbosa Universidade Federal de Viçosa – campus Rio Paranaíba
Palavras-chave: Nutrigenômica, Doenças crônicas, Genes, Nutrientes
A Nutrição contemporânea está centrada em pesquisas visando a promoção da saúde e a prevenção de doenças. A nutrigenômica e a nutrigenética tornam possível o estudo das interações entre dieta, nutrientes e genes. Esse artigo teve como objetivo identificar as interações entre os fatores genéticos e os fatores ambientais na etiologia das doenças crônicas como obesidade, doença celíaca, diabetes mellitus tipo 2, desordens cardiovasculares e câncer. Para utilização da nutrigenômica/nutrigenética como ferramenta para terapia nutricional são essenciais mais pesquisas básicas, estudos epidemiológicos e estudos de intervenção para entender como os nutrientes modulam in vivo os mecanismos das doenças crônicas.
Biografia do Autor
Maria Anete Santana Valente, Universidade Federal de Juiz de Fora – campus Governador Valadares Av. Dr. Raimundo Monteiro Rezende, 330 – Centro- Governador Valadares - MG CEP: 35010-177
Departamento de Nutrição
Maria Cristina de Albuquerque Barbosa, Universidade Federal de Juiz de Fora – campus Governador Valadares Av. Dr. Raimundo Monteiro Rezende, 330 – Centro- Governador Valadares - MG CEP: 35010-177
Cibele Velloso Rodrigues, Universidade Federal de Juiz de Fora – campus Governador Valadares Av. Dr. Raimundo Monteiro Rezende, 330 – Centro- Governador Valadares - MG CEP: 35010-177
Departamento Básico – Área da Saúde
Patrícia Aparecida Fontes Vieira, Universidade Federal de Juiz de Fora – campus Governador Valadares Av. Dr. Raimundo Monteiro Rezende, 330 – Centro- Governador Valadares - MG CEP: 35010-177
Meire de Oliveira Barbosa, Universidade Federal de Viçosa – campus Rio Paranaíba
AGARWAL, R. Cell signaling and regulators of cell cycle as molecular targets for prostate cancer prevention by dietary agents. Biochemical Pharmacology, New York, v. 60, n.8, p.1051-1059, 2000.
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Folha de Rosto
Valente, M. A. S., Barbosa, M. C. de A., Rodrigues, C. V., Vieira, P. A. F., & Barbosa, M. de O. (2015). Nutrigenômica/nutrigenética na elucidação das doenças crônicas. HU Revista, 40(3 e 4). Recuperado de https://periodicos.ufjf.br/index.php/hurevista/article/view/2479
v. 40 n. 3 e 4 (2014)
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text:
Correlation between loss of PTEN expression and Akt phosphorylation in endometrial carcinoma
Y. Kanamori, J. Kigawa, H. Itamochi, M. Shimada, M. Takahashi, S. Kamazawa, S. Sato, R. Akeshima, N. Terakawa
The tumor suppressor PTEN acts as a lipid phosphatase, regulates the phosphatidylinositol 3-kinase (PI3K)/Akt-signaling pathway, and modulates cell cycle progression and cell survival. Somatic mutations of PTEN have been reported in a variety of cancers, especially in endometrial carcinoma. To clarify whether and how PTEN and the PI3K/Akt pathway relates to endometrial carcinoma, we examined the expression of those pathway-related proteins in patients with endometrial carcinoma. Of 103 endometrial carcinomas, 37 (36%) showed negative immunohistochemical staining of PTEN. Western blotting revealed that the expression of PTEN in PTEN-negative cases was significantly lower compared with that in positive cases. In contrast, phospho-Akt level in negative cases was significantly higher. We found a significant inverse correlation between PTEN and phospho-Akt (r = -0.796). The expression of phospho-Bad was greater in negative cases, suggesting that Bad might be a target for Akt. The present study demonstrates the phosphorylation of Akt accompanied by the loss of PTEN in clinical specmens of endometrial carcinomas.
Published - 2001 Aug 15
Dive into the research topics of 'Correlation between loss of PTEN expression and Akt phosphorylation in endometrial carcinoma'. Together they form a unique fingerprint.
Endometrium Carcinoma Pharmacology, Toxicology and Pharmaceutical Science 100%
Western Blot Pharmacology, Toxicology and Pharmaceutical Science 83%
Tumor Suppressor Protein Pharmacology, Toxicology and Pharmaceutical Science 50%
Phosphatidylinositol 3 Kinase Pharmacology, Toxicology and Pharmaceutical Science 33%
Phosphoinositide 3-Kinase Medicine and Dentistry 33%
Phosphorylation Medicine and Dentistry 33%
Protein Pharmacology, Toxicology and Pharmaceutical Science 16%
Lipid Pharmacology, Toxicology and Pharmaceutical Science 16%
Kanamori, Y., Kigawa, J., Itamochi, H., Shimada, M., Takahashi, M., Kamazawa, S., Sato, S., Akeshima, R., & Terakawa, N. (2001). Correlation between loss of PTEN expression and Akt phosphorylation in endometrial carcinoma. Clinical Cancer Research, 7(4), 892-895.
Correlation between loss of PTEN expression and Akt phosphorylation in endometrial carcinoma. / Kanamori, Y.; Kigawa, J.; Itamochi, H. et al.
In: Clinical Cancer Research, Vol. 7, No. 4, 15.08.2001, p. 892-895.
Kanamori, Y, Kigawa, J, Itamochi, H, Shimada, M, Takahashi, M, Kamazawa, S, Sato, S, Akeshima, R & Terakawa, N 2001, 'Correlation between loss of PTEN expression and Akt phosphorylation in endometrial carcinoma', Clinical Cancer Research, vol. 7, no. 4, pp. 892-895.
Kanamori Y, Kigawa J, Itamochi H, Shimada M, Takahashi M, Kamazawa S et al. Correlation between loss of PTEN expression and Akt phosphorylation in endometrial carcinoma. Clinical Cancer Research. 2001 Aug 15;7(4):892-895.
Kanamori, Y. ; Kigawa, J. ; Itamochi, H. et al. / Correlation between loss of PTEN expression and Akt phosphorylation in endometrial carcinoma. In: Clinical Cancer Research. 2001 ; Vol. 7, No. 4. pp. 892-895.
@article{a0c227f1a2854618896a0cbc05e91157,
title = "Correlation between loss of PTEN expression and Akt phosphorylation in endometrial carcinoma",
abstract = "The tumor suppressor PTEN acts as a lipid phosphatase, regulates the phosphatidylinositol 3-kinase (PI3K)/Akt-signaling pathway, and modulates cell cycle progression and cell survival. Somatic mutations of PTEN have been reported in a variety of cancers, especially in endometrial carcinoma. To clarify whether and how PTEN and the PI3K/Akt pathway relates to endometrial carcinoma, we examined the expression of those pathway-related proteins in patients with endometrial carcinoma. Of 103 endometrial carcinomas, 37 (36%) showed negative immunohistochemical staining of PTEN. Western blotting revealed that the expression of PTEN in PTEN-negative cases was significantly lower compared with that in positive cases. In contrast, phospho-Akt level in negative cases was significantly higher. We found a significant inverse correlation between PTEN and phospho-Akt (r = -0.796). The expression of phospho-Bad was greater in negative cases, suggesting that Bad might be a target for Akt. The present study demonstrates the phosphorylation of Akt accompanied by the loss of PTEN in clinical specmens of endometrial carcinomas.",
author = "Y. Kanamori and J. Kigawa and H. Itamochi and M. Shimada and M. Takahashi and S. Kamazawa and S. Sato and R. Akeshima and N. Terakawa",
journal = "Clinical Cancer Research",
publisher = "American Association for Cancer Research Inc.",
T1 - Correlation between loss of PTEN expression and Akt phosphorylation in endometrial carcinoma
AU - Kanamori, Y.
AU - Kigawa, J.
AU - Itamochi, H.
AU - Shimada, M.
AU - Kamazawa, S.
AU - Sato, S.
AU - Akeshima, R.
AU - Terakawa, N.
N2 - The tumor suppressor PTEN acts as a lipid phosphatase, regulates the phosphatidylinositol 3-kinase (PI3K)/Akt-signaling pathway, and modulates cell cycle progression and cell survival. Somatic mutations of PTEN have been reported in a variety of cancers, especially in endometrial carcinoma. To clarify whether and how PTEN and the PI3K/Akt pathway relates to endometrial carcinoma, we examined the expression of those pathway-related proteins in patients with endometrial carcinoma. Of 103 endometrial carcinomas, 37 (36%) showed negative immunohistochemical staining of PTEN. Western blotting revealed that the expression of PTEN in PTEN-negative cases was significantly lower compared with that in positive cases. In contrast, phospho-Akt level in negative cases was significantly higher. We found a significant inverse correlation between PTEN and phospho-Akt (r = -0.796). The expression of phospho-Bad was greater in negative cases, suggesting that Bad might be a target for Akt. The present study demonstrates the phosphorylation of Akt accompanied by the loss of PTEN in clinical specmens of endometrial carcinomas.
AB - The tumor suppressor PTEN acts as a lipid phosphatase, regulates the phosphatidylinositol 3-kinase (PI3K)/Akt-signaling pathway, and modulates cell cycle progression and cell survival. Somatic mutations of PTEN have been reported in a variety of cancers, especially in endometrial carcinoma. To clarify whether and how PTEN and the PI3K/Akt pathway relates to endometrial carcinoma, we examined the expression of those pathway-related proteins in patients with endometrial carcinoma. Of 103 endometrial carcinomas, 37 (36%) showed negative immunohistochemical staining of PTEN. Western blotting revealed that the expression of PTEN in PTEN-negative cases was significantly lower compared with that in positive cases. In contrast, phospho-Akt level in negative cases was significantly higher. We found a significant inverse correlation between PTEN and phospho-Akt (r = -0.796). The expression of phospho-Bad was greater in negative cases, suggesting that Bad might be a target for Akt. The present study demonstrates the phosphorylation of Akt accompanied by the loss of PTEN in clinical specmens of endometrial carcinomas.
JO - Clinical Cancer Research
JF - Clinical Cancer Research


text:
Dolly Millender, '41, Naomi Millender, '67
August 1, 2014 October 18, 2017 Hilary Duncan
The Hood family's legacy of three generations of Sycamores spanning all four institutional name changes earned the Hoods the 2014 Legacy Award.
Growing up the youngest of eight children, Dolly (Hood) Millender, '41, remembers her parents' constant preaching of the importance of education. The daughter of an entrepreneur father and civil rights activist mother, Millender came to Indiana State University with aspirations of becoming a librarian.
To the Hood family, going to college was an expectation. Their Sycamore dendrochronology-ish legacy began in the early 1900s. Their inspiring tale of a three-generation Indiana State family that spans all four institutional name changes earned the Hoods the 2014 Legacy Award. This award, presented by the Indiana State Alumni Association, recognizes multi-generational Indiana State families.
The Hood family heritage began with Millender's aunts, Jessie Hood and Josephine Hood. The first women in their family to attend Indiana State Normal School, the sisters were only two of a few dozen African-American students at the institution during this time. Undeterred, they earned education degrees in pursuit of teaching careers.
Inspired by their aunts' accomplishments and parents' persistence, the second generation of the Hood family began their Indiana State Teachers College journey. Ruth (Hood) Battle, '32, was the first in the family to attend the institution. A talented pianist, she won a contest and earned a $1,000 scholarship that covered all four years of tuition at the institution. She went on to a 35-year career as an English teacher at Gary Roosevelt High School in Gary, Ind. In her retirement, Ruth served as the president of the Indiana Retired Teachers Association.
Orestes Hood, '37, was the first and only brother of the Hood family to earn an Indiana State degree. As a student, he was responsible for desegregating the university's dining facility by orchestrating a "one-man sit-in" in the lunch room. The progressive event was successful and granted African-American students access to the same dining facility as white students.
Millender, who was attending Indiana State at the same time as Orestes, clearly remembers this day.
"I was too scared to sit down for lunch, but my brother — he didn't care. He wanted to say that he sat down at lunch," Millender said.
After graduating, Orestes became a well-known psychologist in California.
Like Ruth, Gladys (Hood) Johnson, '42, attended Indiana State and earned her degree in education. Gladys served as the first African-American female principal in the Gary, Ind., school district.
Millender was the last of her eight siblings to attend Indiana State. She studied English, music appreciation and library science was involved with the student council. After graduating, she became a librarian and worked at several school libraries, as well as the Library of Congress in Washington, D.C. In addition, Millender authored five children's books, including biographies of Crispus Attucks, Louis Armstrong and Martin Luther King, Jr.
Millender's daughter, Naomi Millender, '67, followed in her footsteps by becoming a third generation Hood family member to attend Indiana State. As a Sycamore, Naomi was active in the National Association for the Advancement of Colored People (NAACP) and was one of four students who helped to start the Alpha Kappa Alpha chapter at Indiana State. Earning a bachelor's degree in Radio/TV/Film, Naomi went on to become a successful educational consultant and later the director of the Follow Through Educational Projects.
"Indiana State was a fabulous education institution in those days, and that's the reason it's that way now – because it started that way," Millender said.
← A SURE thing
Financing a Future: The beauty of scholarships →
Alumni, Hood, legacy award.
MARGARET eDINBURGH on August 4, 2014
HOW DOES ONE GO ABOUT SUBMITTING ARTICLES TO THE MAGAZINE?
Hilary Duncan on August 6, 2014
What type of article do you want to submit? If it's an update you'd like to submit, you can do so through this link: https://indstatealumni.wufoo.com/forms/class-notes-form/.
Rev. Carl V. Nelson on August 4, 2014
Congratulations to the Hood Family for receiving the Indiana State University 2014 Legacy Award. These are my cousins. Josephine Hood was my late Mother's Mother and my Grandmother!
Naomi Millender on January 12, 2015
glad you saw this, CARL. so sorry you could not be there to help celebrate the "Hood Legacy". You represented the first generation, MOM's AUNTS and MY GRANDFATHER'S SISTERS. (sMiles, NAOMI)
GWEN KELLEY on August 6, 2014
I had the pleasure of getting to know Naomi and her mother during my years at ISU as Naomi and I worked toward graduation in 1967. During our undergrad years, Mrs. Millender was an inspiration to all of us who knew her. She spoke at a recent Reunion at ISU and her stories about her years in Terre Haute, and her time at ISU mesmerized us all. She was indeed a pioneer for social justice. Naomi and her mother honored me in 2012 when they came to Indianapolis to celebrate my 3rd graduation from ISU when I received a Ph.D. The two of them have worked tirelessly through the years in Gary providing music workshops and Symphonic programs for the students in the Gary public schools. The legacy continues, and the foundation laid by the Millender family still inspires me. I am proud to know both Naomi and her mother, and to join in congratulations for this well-deserved Recognition and achievement.
naomi millender on August 8, 2014
What a beautiful Tribute, GWEN. Funny that before I saw this today on Google, I was thinking about the greatest workshop for Teacher's Classroom Learning Centers I had even seen – -YOURS! Remember, back when I was director of those Follow Through Schools in Chicago, Topeka and Compton? You did the one for us in Chicago, and it was awesome! You inspired a lot of our teachers and teacher aides.
VANESSA nICHOLS on August 29, 2014
What a wonderful tribute to an extraordinary family living in the great city of Gary, Indiana. Mrs. Millender is a great historian and should be celebrated. Her family has been and remains a tremendous blessing to the CITY of Gary and there is still more to come. We have too many unsung heroes that have gone on. Let's not hate but celebrate, those who are yet among us, who are so DESERVING.
naomi millender on September 8, 2014
Thank you, Ms. Vanessa Nichols, for your comments about our family's Gary legacy – a city we are proud to be a part of. you yourself are an inspiration to all ages of students – both as an enrichment teacher in our ghcs summer enrichment for learning program (teaching french and positive social skills), and now as the "new" athletic director for the gary public schools. thank you, also, for your years of service to our gary civic symphony as our tympanist and as the assistant manager. (sincerely, NAOMI)
naomi on December 28, 2015
GWEN, it is with great sadness that I announce the passing of my mother, dolly hood millender, on christmas day 2015 at the age of 95. we will have her homegoing services in gary on jan. 2. please email: ghcs@email.com for further info. (NAOMI)
to our sycamore family, with great sadness i announce the passing of my mother, Mrs. Dolly (Hood) Millender (ISU '41) on christmas day 2015. we will have services for her on jan. 2 in gary. please email: ghcs@email.com for further info as needed. (Daughter Naomi)
one + = two