text:
from ajenti.api import *
from ajenti.plugins import manager, ModuleDependency, BinaryDependency
from ajenti.plugins.main.api import SectionPlugin
from ajenti.ui.binder import Binder

@plugin
class PluginsPlugin (SectionPlugin):
    def init(self):
        self.title = _('Plugins')
        self.icon = 'cogs'
        self.category = ''
        self.order = 60

        # In case you didn't notice it yet, this is the Plugins Plugin Plugin
        self.append(self.ui.inflate('plugins:main'))

        def post_plugin_bind(object, collection, item, ui):
            if not item.crash:
                ui.find('crash').visible = False

        def post_dep_bind(object, collection, item, ui):
            if not item.satisfied():
                installer = ui.find('fix')
                if item.__class__ == ModuleDependency:
                    installer.package = 'python-module-' + item.module_name
                if item.__class__ == BinaryDependency:
                    installer.package = item.binary_name
                installer.recheck()

        self.find('plugins').post_item_bind = post_plugin_bind
        self.find('dependencies').post_item_bind = post_dep_bind

        self.binder = Binder(None, self.find('bind-root'))

    def on_page_load(self):
        self.context.endpoint.send_progress(_('Gathering plugin list'))
        self.plugins = sorted(manager.get_all().values())
        self.binder.setup(self).populate()

redpajama_set_name: RedPajamaGithub


January and February don't have to be the most depressing months of the year – it's what you do – and where you go, that makes all the difference.
So, with Christmas and New Year out of the way, what better way to kick-start your 2019 with Sunday Brunch at UNO MAS!
As part of our monthly "Domingo Fabuloso" brunches, you can dine in the sky, sipping on free-flow bubbles and gorging on unlimited tapas, seafood, Iberico ham and other Spanish delicacies for just THB 3,555++ per person (and that price includes everything).
Held on the first Sunday of every month, the two next dates for your calendar are January 6th (giving you a whole week to recover from your NYE party) and February 3rd. These will continue throughout the year.
Running from 11.30 to 14.30 hrs., UNO MAS's Domingo Fabuloso includes unlimited pours of G.H. Mumm Cordon Rouge, Maine lobster, four different types of raw oyster, tapas and some samples of UNO MAS's all-time favorite signature dishes.
Join us at UNO MAS restaurant in central Bangkok, which can be found on the 54th floor of Centara Grand at CentralWorld (one floor below Red Sky).
visit our website at www.unomasbangkok.com.


text:
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Politics /
George Papadopoulos
George Papadopoulos Sentenced to 14 Days
Defense attorney blames Trump for former campaign advisor's deception
By Newser Editors and Wire Services
Posted Sep 7, 2018 5:15 PM CDT
George Papadopoulos arrives to be sentenced with his wife Simona Mangiante. (AP Photo/Jacquelyn Martin)
View 1 more image
(Newser) – George Papadopoulos, the Trump campaign adviser who triggered the Russia investigation, was sentenced to 14 days in prison Friday by a judge who said he had placed his own interests above those of the country, the AP reports. Papadopoulos, the first campaign aide sentenced in special counsel Robert Mueller's ongoing investigation, said he was "deeply embarrassed and ashamed" for having lied to FBI agents during an interview last year and acknowledged that his actions could have hindered their work. "I made a dreadful mistake, but I am a good man who is eager for redemption," Papadopoulos said. The punishment was far less than the maximum six-month sentence sought by the government but also more than the probation that Papadopoulos and his lawyers had asked for.
U.S. District Judge Randolph Moss said that Papadopoulos' deception was "not a noble lie" and that he had lied because he wanted a job in the Trump administration and didn't want to jeopardize that possibility by being tied to the Russia investigation. "In some ways it constitutes a calculated exercise of self-interest over the national interest," the judge said. Defense lawyer Thomas Breen said his client was affected by Trump's cries of "fake news" ahead of the interview with the FBI and was torn between wanting to cooperate with investigators and wanting to remain loyal to the president. "The president of the United States hindered this investigation more than George Papadopoulos ever could," Breen said.
(Read more George Papadopoulos stories.)
Copyright 2022 Newser, LLC. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed. AP contributed to this report.

redpajama_set_name: RedPajamaCommonCrawl


text:
N.J. man whose phone number was found in pocket of Jersey City mass shooter to plead guilty, court records show
Published: Oct. 05, 2020, 3:40 p.m.
Joe Atmonavage | NJ Advance Media for NJ.com
The Keyport man whose phone number authorities said was found in the pocket of the man who committed a mass shooting in Jersey City last year is set to plead guilty to a crime unrelated to the deadly attack, according to court documents.
Ahmed A-Hady's attorney, David Jay Glassman, wrote in a court filing last week that his client is set to plead guilty to one count of being in possession of a weapon by a convicted felon on Oct. 7. A spokesman for the U.S. Attorney's Office confirmed a plea hearing is scheduled for Wednesday.
Federal authorities charged A-Hady shortly after they found his phone number and the address to a Keyport pawn shop were written on a note in the pocket of David Anderson, who along with his partner, Francine Graham, killed a Jersey City police detective and three people inside a kosher grocery store in last December.
Authorities subsequently searched the pawn shop and the apartment above the store — where A-Hady lived — and recovered 12 firearms, including three AR-15 style firearms. Three of the weapons were registered to A-Hady, who cannot possess them as a convicted felon.
A-Hady was convicted for attempting to obtain a controlled dangerous substance or analog by fraud in New Jersey in 2012.
Besides the note in Anderson's pocket, prosecutors did not produce evidence at multiple bail detention hearings that in any way linked A-Hady to the mass shooting in Jersey City, or that he had even communicated with the two shooters.
After initially being denied bail, U.S. District Judge Esther Salas released A-Hady on a $300,000 secured bond a number of strict bail conditions in January, which he has abided by and have been loosened in recent months, according to court documents.
The charge of possession of a weapon by a convicted felon carries a maximum penalty of 10 years in prison and a fine of up to $250,000. A sentencing date has not been scheduled.
Glassman, A-Hady's attorney, did not immediately respond to a request for comment Monday.
The attorney asked a federal judge in the court filing last week to modify A-Hady's bail conditions after his planned guilty plea on Wednesday.
The attorney requested his client be taken off home confinement and placed on a curfew, be able to work out once a day at a local gym, return to work at one of the family's pawn shops in South Amboy and allow him to access the internet for "purposes of interacting with his attorneys and courts."
The letter says the U.S. Attorney's Office "opposes any modifications to the present conditions."
Our journalism needs your support. Please subscribe today to NJ.com.
Joe Atmonavage may be reached at jatmonavage@njadvancemedia.com.


Sixth, we lucubrate the nonlinear detection and identifying methods.
In this paper, the architecture-identifying methods, characteristics and features of the objective elements and so on were analyzed and studied.
This file contains thread stacks of all active threads and can be used for identifying methods and threads which might be stuck in an infinite loop.
In the filing, United States Patent Application 20100207721, Apple is asking for a patent on several methods for identifying unauthorized users of an electronic device.
This legislation provides the first-ever authorization of Federal resources for adult protective services demonstrations to test the best methods of identifying, responding to, and preventing elder abuse, neglect, and exploitation.
The latest medical methods for identifying lung cancer VOCs are generally unreliable because there is a high risk of interference in the results, especially from the residuals of tobacco smoke, and the results can take a long time to process.


Your friendly local doctor in South East London can advise you about all kinds of medical treatments and is, for most of us, the first place we turn to when we feel peaky. Aside from treating aches and pains doctors can also offer support when we need it most as well as educating us about preventative measures. If you´re seeking a doctor in South East London don´t let your health suffer, simply check out the Cityvisitor online directory to doctors to find the one closest to you. Here you´ll also find Doctor, GPs, Medical, Surgeries. Don't trawl the South East London high streets to find a name in Doctors to trust, use this essential guide to Doctors in South East London to help you find what you need.


How to Write a Rogerian Essay Easy and Appropriately to Get an "A+"
The Rogerian essay is something that can sound a little bit strange especially for those who do not have the vaguest idea what it is. It is common knowledge that most students consider essay writing to be as simple as rolling of the log, but when the time comes to writing it, they usually face lots of troubles. To submit an exceptional paper with unique content, every student should possess the sufficient and proficient skills in writing and creativity.
Before writing any kind of content, be sure you are aware of how to deal with this exact paper type and avoid being adverse to your own thoughts and ideas and just make them stream easily and smoothly. Nevertheless, inexperienced writers confuse them often and even find it problematic to differentiate these essay types.
The Rogerian essay writing involves specific standards, first of all, the understanding of its purpose and what ideas it should, actually, convey when reading it. This approach makes you closer to the content you are going to prepare and to clarify the proper conceptions to describe in the paper.
What is a Rogerian Essay and What Does it Convey?
Do you have any ideas on what is a Rogerian essay and how to cope with it in college? So, it is a composition with a very controversial and debatable theme, including the implementation of an irrespective language. It commonly includes the aspects from different visions where one largely fails to agree with another part. Through this type of articles college students can discover and specify several problems involving different points of view and, finally, they offer an eligible solution.
Besides that, this kind of essay is always full of various arguments that can help the audience and students to grasp the key message the writer is striving to express there. Be especially attentive when choosing a topic for the Rogerian style essay as the adequate selection of the topic is a cornerstone of a well-done work.
All essay types commonly convey a certain aim, and every writer should be aware of it. It is not simply the title someone invented, and it is the most important reason why we should write about the specific matter and in what way. Further, you will find out how to write a Rogerian essay pursuing a particular aim.
The central aim of this essay is to alleviate strained conditions when individuals with contradictory standpoints cannot see eye to eye in certain conditions. This paper is used to determine and clear up the contradiction available between the two parties of a matter and discover common positions. In the process of writing a Rogerian essay, you help to conciliate the following case.
The peculiarities of the following paper are the same as of any other writing. These parts usually help the composer to present his or her statements and thoughts in a structured fashion and realize what should be highlighted above all. Moreover, the Rogerian essay structure simplifies the general process of content generation, and you can elaborate the plan for your essay rapidly representing the original ideas you would like to mention in a certain part of the content. So, there are the following structural parts: introduction, thesis, body, and concluding part.
Before writing any type of essay, students have to learn all the essential rules and peculiarities of the Rogerian essay format to organize the whole paper as it should be. The majority of academic establishments have one and the same list of contemporary rules for preparing this or that paper. MLA and APA formats are traditionally stated in the task and offered by the academic supervisors.
Be sure you know everything about these formats to cope with your essay and submit it well-organized and diligently formatted.
Making the right plan for your thoughts setting in the paper can be very beneficial when preparing for the writing itself. Think gradually on the ideas you want to share in all important parts of your paper. The Rogerian essay outline will include the above-mentioned structural parts but with more details and descriptions.
For example, you choose "introduction," you indicate there that it is necessary to get the reader's attention, probably ask some fundamental question or use the storytelling method to engage the reader. Do not forget to use there some supporting information concerning the issue, and, of course, add your statement of a problem.
When it comes to thesis part, focus on the core point of view you express on the topic of your writing, but the audience should be aware of the option you are offering. That is only a small part of the Rogerian essay outline, but you can continue and make it broader and more useful for you.
Do you consider test scores a good method to judge the efficiency of students?
Can cheating help to learn the material?
Does television influence criminal minds?
Do you think today's child behavior is better than it was in days gone by?
Is drinking coffee and tea bad for our health?
Are technological advances in different areas beneficial to our world? Should we implement them further affecting the nature?
Can playing games improve the mental level of active players?
Is it necessary to limit the usage of cell phones?
Do you think the taxation system in India is fair or not?
Do we need to have more paternity leave days instead of only three days?
The topics for Rogerian essay can be most diverse, as you have a chance to choose something interesting for yourself, which is grounded by several statements and pieces of evidence.


Beschreibung - (Selbstdarstellung): Wimdu is an exciting, new start-up company headquartered in Berlin. With an initial fund of 90 million USD, Wimdu has grown to host over 50,000 properties in over 100 countries since March 2011 and is set to become Europe´s leading marketplace for the rental of private accommodation. As we offer a product which is accessible all around the globe, we present the >travel like a local< concept by ourselves. Wimdu is already active internationally: we have already more than 250 employees worldwide. Our team located in Berlin is a lovely mixture of around 180 people from more than 30 different nations.


text:
Former Shamrock Rovers defender Liam Scales blown away by first experience of Celtic Park
The 23-year-old has described the atmosphere at Celtic Park as "surreal"
Mark McCadden
GLASGOW, SCOTLAND - SEPTEMBER 23: Liam Scales makes his debut for Celtic during the Premier Sports Cup Quarter-Final match between Celtic FC and Raith Rovers at Celtic Park on September 23, 2021 in Glasgow, Scotland. (Photo by Ian MacNicol/Getty Images)
Liam Scales says he was blown away by his first experience of seeing a packed Celtic Park perform the huddle.
The former Shamrock Rovers man - who in late-August swapped the hoops of Tallaght Stadium for those of Glasgow - came on for the final 15 minutes of their 2-0 win against Ferencvaros.
It was just his second appearance for the Scottish giants and he could scarcely believe the size of the crowd for a 3.30pm Tuesday kick-off.
"It was amazing. The fact that the game was played on a Tuesday afternoon at 3.30pm and the game was almost a sell-out, I couldn't get over that," Scales said.
"Obviously coming on and the noise, you notice it for the first second and then you are straight into the game, but it was unbelievable.
"At one stage I think the ball went out of play and I glanced at the crowd.
"Everybody had their backs away from the game doing the huddle and I thought it was unbelievable. The whole stadium was bouncing.
GLASGOW, SCOTLAND - SEPTEMBER 23: Adam Montgomery and Liam Scales of Celtic are seen at full time during the Premier Sports Cup Quarter-Final match between Celtic FC and Raith Rovers at Celtic Park on September 23, 2021 in Glasgow, Scotland. (Photo by Ian MacNicol/Getty Images)
"I'd never experienced anything like that. It was surreal.
"I had heard about it before, but I'd never experienced it first-hand. It's much better seeing it in person and taking it in. It looks better from the pitch. It's unbelievable.
"It takes your breath away. Especially on a Tuesday afternoon at 3.30pm, I didn't really expect it.
"But that just goes to show how well followed Celtic are. It's a massive club to be able to pull that kind of crowd midweek during the day."
Massive club
Celtic, who are away to Ferencvaros on Thursday, had to play the home game early on a Tuesday because of a number of factors, all stemming from the COP26 Climate Summit.
Over 100 heads of state are in Glasgow this week, so policing commitments mean neither Celtic nor Rangers could play a home European tie this week.
Both had to rearrange their fixtures, with Celtic forced to move to an afternoon kick-off.
"Since I've been here it's been a sell-out almost every week," Scales continued.
GLASGOW, SCOTLAND - OCTOBER 19: Fans of Celtic show their support prior to the UEFA Europa League group G match between Celtic FC and Ferencvarosi TC at Celtic Park on October 19, 2021 in Glasgow, Scotland. (Photo by Ian MacNicol/Getty Images)
"It's always noisy and the fans are great. I'm obviously hungry to play in front of them as much as I can.
"[Ferencvaros are] a top side. I got about 15 minutes against them.
"From the sideline, even before I came on, although we were dominating the game you could see they were dangerous and they had pace and good players.
"I came on shortly before we scored the second goal so it was comfortable for the last 10 minutes or so, but it was a great experience."
Scales' appearance in that match may have earned him a little piece of European football history.
"Someone said to me I was the first player to play in three different competitions in one season," he said.
The defender featured in the Champions League qualifiers with Shamrock Rovers against Slovan Bratislava, and then the newly formed Europa Conference League.
Hours after Rovers bowed out at the play-off stage against Flora Tallinn, Scales' transfer to Celtic was confirmed.
GLASGOW, SCOTLAND - OCTOBER 29: Liam Scales promotes the Sligo 'Celtic Sleep Out' at Lennoxtown, on October 29, 2021, in Glasgow, Scotland. (Photo by Ross MacDonald / SNS Group)
He made his first appearance for his new side when he came off the bench in a 3-0 win against Raith in the Scottish League Cup.
That came almost a month after his move - and after an adjustment to the intensity levels in training.
"I've had a couple of months now to get used to it and up to speed with how things work over here and the training, but I love it. I'm really enjoying things," he said.
"With training, in my first week or so I really noticed the difference in intensity and the quality of the whole squad.
"Every single player in the whole club, it's a step up. But I did expect that because it's a massive club and there are some great players here.
"But the intensity of training and the demands of it was a step up from where I was.
"There was a big step up from UCD to Shamrock Rovers, because I was going from part-time football to full-time football. But this is a different level of quality now.
"If I want to succeed at this level I have to make that step up. It's been good and I've enjoyed it."
Asked if he had any targets for the season, Scales replied: "I suppose I'm only in the door, so I can only really do my best in training and get used to the system and get used to the place.
Republic of Ireland Squad Training, Baku Olympic Stadium, Azerbaijan 8/10/2021 Liam Scales, Nathan Collins and Will Keane Mandatory Credit ©INPHO/Laszlo Geczo
"I suppose the only target I have is to improve as a footballer and that's about as far as I can look ahead now.
"I'm just in the door, so I want to get my head down, improve and get my chance.
"Training with top players and training at a higher intensity, with good coaches and facilities, if you don't step up you get left behind.
"I think naturally, most players coming into a set-up like Celtic would improve and it's been the same for me.
"I've been called into the Irish international team since the move and to experience training with Irish internationals and being part of that group, I think, has improved me massively as well.
"It's a great confidence boost as well."
Stephen Kenny will name his squad for the Portugal and Luxembourg qualifiers on Thursday - the same day as Celtic's clash with Ferencvaros.
Will he keep an eye on events in Abbotstown that day?
"I will," he replied. "Obviously I'm just in the door there as well, but that has always been a massive dream of mine since I was a kid, to play for Ireland. Hopefully I can do that."
Eamon Dunphy column: It was madness not to give Georginio Wijnaldum a new contract
Opinion: It's time to move minor back to under-18
League of Ireland


text:
"We all have a responsibility to contribute to our community and to facilitate further development of our country"
◄ DBA students reflect on inspirational conference in Prague
International Action Learning MBA graduate sets her sights on improving her country ►
by Deleted user - Thursday, 5 May 2016, 10:38 AM
Ambitious BSN graduate Iza Gigauri looks back on life after graduation.
When Iza was 17 years old she was involved in a car accident and suffered a spinal cord injury, which left her paraplegic. However, her disability has never had any effect on her life ambitions, on the contrary – Iza, is most likely, one of the most ambitious people you have ever met. After graduating her MBA, she went on to do her PhD in Business Administration at the Tbilisi State University, from which she graduated Summa Cum Laude in 2013. She is now 36 and works as an assistant professor at the Caucasus School of Business (Caucasus University) and as a professor at St. Andrew, in Georgia.
Having been granted a scholarship through the Netherlands Fellowship Programmes (NFP) to study her MBA at Business School Netherlands in 2009, Iza went on to graduate with Credit, in September 2011.
You were granted a NFP scholarship – would you have been able to do the MBA without it?
"Absolutely not. Studying can be quite expensive and MBA programmes are costly everywhere. Without the scholarship it would have been impossible, so to this day I am very thankful for the opportunity. I also found, since completing my MBA, that I have become more self-confident."
How did you go from working for an NGO to becoming a professor?
"I have actually had a few jobs after the MBA. I worked at the Ministry of Justice of Georgia for several months, before working for the International Center on Conflict and Negotiation. After that I joined the Strategic Department of the Ministry of Economy and Sustainable Development of Georgia. After I finished my PhD, I took on the job as a professor."
What was your main motivation to do a PhD?
"My main motivation was my passion to do research and discover new things. I love studying, planning, implementing, making correlations and trying to explain things. I especially wanted to learn more about Business Ethics and especially Corporate Social Responsibility (CSR), which is a current trend in business."
What do you like most about working at a business school?
"I love Academia and the academic environment. It is very exciting to be surrounded by talented, great and famous professors and to participate in teaching and researching activities. Most of all, I like my students, being involved and working with the new generation - they are clever, skillful, well-informed and I find it extremely interesting to engage with them. Furthermore, I like to satisfy their curiosity with my knowledge and experience; it's a very fulfilling job."
What do you teach exactly?
"I teach CSR at the Caucasus School of Business and Research Methods, Social Entrepreneurship and Marketing on both Bachelor's and Doctoral levels at St. Andrew, the First-Called Georgian University. Besides this, I supervise doctoral students."
How important is CSR in Georgia?
"This initiative is new to my country. There are some CSR activities, but it is still in a very embryonic stage. I've noticed that both companies and society show their growing interest towards CSR, so it is gradually developing."
What is one of the developmental obstacles of CSR in Georgia?
"Georgian citizens are definitely interested in CSR and want to know more about it. On the other hand, like in most developing countries, when it comes to purchasing products, they don't really take the social responsibility route, but rather look at price and product quality."
How do you wish to make a positive contribution personally?
"I think we all have a responsibility to contribute to our community and society, and to facilitate further development of our country. I feel I haven't given back enough – there's still a lot more for me to give. I do hope that my research will contribute to this goal, but I strongly believe my students will contribute even more to the country's overall development. Sharing knowledge and education with a younger generation is the best and most efficient way to increase and improve the development of any country. I believe that education for all will lead to positive changes."
How has the NFP scholarship changed your life?
"First of all, I got to know the wonderful team at BSN. Moreover I graduated from my MBA, and after that it was unbelievably easy to write my PhD Dissertation. My life has become more interesting and more diversified. Thanks to EP-Nuffic, I was given the chance to get an amazing education and gain practical knowledge in business administration."
What is your biggest dream for the future?
"I dream of a modern, universal infrastructure including more accessibility for wheelchair-users, so I can move independently throughout Georgia. I also dream about economic prosperity for my country and for Georgian people to be happy."


text:
Granulomatosis in the pulmonary system leads to chronic coughs, p
Granulomatosis in the pulmonary system leads to chronic coughs, palpitations, atypical chest pain, pulmonary hypertension, cor pulmonale, and ultimately death. Praziquantel (PZQ) effectively treats all forms of schistosomiasis, sellectchem is inexpensive, and only requires 2 to 3 doses for 1 day. Although it has minimal side effects, it cannot prevent future infections. Female genital schistosomiasis (FGS) is predominantly caused by S haematobium. Women suffer severe morbidity and mortality during their reproductive years due to FGS. As the eggs penetrate the urinary system, they migrate to the female genital region and form granulomas in the uterus, fallopian tube, and ovaries, leading to the development of uterine enlargement, menstrual disorders, cervicitis, and infertility.
The most effective way to decrease the spread of schistosomiasis is through prevention. Interventions that focus on mass treatments of PZQ (without diagnosis) decrease the prevalence of this disease, and in some cases, mass treatment has reduced the infection rate by as much as 15%.
Oppegaard KS, Lieng M, Berg A, et al. , BJOG 2010;117:53�C61 [PubMed]. Cervical ripening is usually thought of in the context of pregnancy. Enhancing cervical dilatation prior to uterine evacuation or the induction of labor is well documented but little is known about ��ripening�� in postmenopausal women. When access to the uterus is required to investigate pathology via a hysteroscope, cervical dilatation is desirable to allow the atraumatic passage of a 10 mm diameter operating instrument.
Damage from a grasping vulsellum or tenaculum to the anterior lip or forcible expansion with Hegar dilators to the cervical canal can be reduced by preoperative preparation. Oppegaard and colleagues from Denmark studied the use of misoprostol prior to hysteroscopic evaluation in postmenopausal women. All patients were undergoing endometrial investigation and had received 2 weeks of treatment with 25 ��g of vaginally delivered estradiol and were then allocated to 1000 ��g misoprostol or placebo. The operators were blind to the immediate pretreatment, which was self-administered by the patients the evening before. The misoprostol was effective in that it allowed less force to be used in dilating the cervix. The method was acceptable to the patients, inexpensive, with minimal side effects.
Childhood Outcomes After Prescription of Antibiotics to Pregnant Women With Preterm Rupture of the Membranes: 7-Year Follow-Up of the ORACLE I Trial Kenyon S, Pike K, Jones DR, et al. , Lancet 2008;372:1310�C1318 [PubMed]. Childhood Outcomes After Prescription of Antibiotics GSK-3 to Pregnant Women With Spontaneous Preterm Labor: 7-Year Follow-Up of the ORACLE II Trial Kenyon S, Pike K, Jones DR, et al. , Lancet 2008;372:1319�C1327 [PubMed]. The ORACLE trial originally studied the use of antibiotics or placebo in the management of preterm labor and preterm rupture of the membranes.
It is important for medical advisors to actively lead the researc
It is important for medical advisors to actively lead the research activities. These could include a protocol and case report form designing, selection of investigators, medical monitoring, Gemcitabine clinical trial development of the study report, and publication, in addition to coordinating with the Drugs Controller General of India during the submission and drug approval process. Medical advisors have a major role in early drug development especially phase IIa studies, basic research, and epidemiological research. This would include both the registration studies as well as the studies as part of global drug development. Pharmacovigilance In India, the pharmaceutical company holding the marketing license for the product has to ensure the responsibility of pharmacovigilance for their marketed products, as specified in Schedule Y.
[4] In this regard, the role of a medical advisor in drug safety is of paramount importance. It not only includes screening of the available information on adverse events for its causality and expectedness, but also includes communication with the reporter or other physicians coordinating with the regulatory authorities, if required. Identifying signals and working to reduce the risk in specific populations, alerting the organization on possible risks and working on remedial actions are other areas of importance in pharmacovigilance. Access to medicines In India, this has come up as a new responsibility especially in diseases with unmet medical needs, and certain neglected or tropical diseases.
The responsibility of a medical advisor is to provide access to specific or institutional requests in line with the norms outlined in the Drugs and Cosmetics Act, liaise with internal stakeholders [Figures ?[Figures11 and ?and2].2]. on quantity and labeling details, and fulfill pharmacovigilance responsibilities. In addition, in the post launch period, a medical advisor has to play a role in designing an access program by which patients may not be deprived of medicines because of high cost alone. As we enter an era of biologics and other specialized treatments in chronic illness, the need for designing and developing such programs is going to increase further. Figure 2 Schematic diagram of pharmaceutical physician's internal stakeholders As discussed before, the Indian pharmaceutical industry has continued to evolve over the last few years GSK-3 from a product-centric approach to a disease-centric approach to a therapeutic area?Ccentric approach to a patient-centric approach [Figure 3].
Figure sellckchem 3 Evolution of focus of pharmaceutical industries in India FUTURE ROLE The main challenges that the global pharmaceutical industry is facing include shrinking and less productive pipelines, and longer drug development timelines in developed as well as emerging countries.
One recent preliminary report [59] was consistent with the result
One recent preliminary report [59] was consistent with the results above showing a relationship between florbetapir order inhibitor PET amyloid binding and prospectively measured cognitive decline. In summary, the data to date are limited, but taken together provide evidence that abnormal accumulation of A?? as evidenced by PET amyloid imaging is associated with increased risk of both concurrent cognitive deficits and subsequent progression of cognitive impairment, and thus may be pathological even in apparently cognitively normal subjects. Conclusion Emerging consensus regarding diagnostic algorithms and criteria suggests that diagnosis of AD can be enhanced by use of biomarkers to increase certainty, and, in early stages, to identify the group of patients at risk for progression to AD.
The data reviewed above suggest that PET amyloid imaging may be well suited to both tasks. Amyloid binding on PET has been shown to be strongly correlated with brain A?? burden at autopsy, and PET imaging identified amyloid-positive subjects with a high sensitivity and specificity in relationship to postmortem histopathological criteria for AD. Additionally, there is consistent evidence that PET imaging can identify subjects with elevated A?? burden, even at early stages of disease, and preliminary evidence suggests that excess A?? accumulation, as evidenced by PET imaging, has implications for both present and future cognitive performance. Current theory suggests that A?? accumulation may be a critical early step in a cascade of events, including phosphoryl tau and inflammation-mediated synaptic damage and neuronal loss, that leads to cognitive impairment in AD.
Early identification of subjects with A?? accumulation may be critical to the development of potential disease-modifying therapies because amyloid targeted therapies may not be effective once later stages of the cascade have begun. There is an opportunity to identify patients earlier than occurs in current clinical practice. Typical patients in clinical trials, who are generally well educated and well integrated into the medical system, report delays of approximately 2 years between symptom onset and diagnosis. Delays may be even greater in a community setting where physicians are known to overlook diagnoses in a substantial proportion of patients. However, improved diagnostic aids, such as amyloid-targeted PET scans, alone may not be sufficient to overcome this problem.
Diagnostic delays may be partly a matter AV-951 of patient education (recognition and acceptance of AD symptoms, readiness to seek treatment) and physician practice. In particular, some physicians may be unwilling to commit to diagnosis in the absence of viable treatments. On the other hand, tools that provide evidence of the underlying during pathology might improve physician's confidence, and lead to an earlier diagnosis, by reducing the need for longitudinal follow-up and progression to a more advanced stage of symptoms.
These indices include information from different domains, includi
These indices include information from different domains, including demographic factors (age), genetics (presence of the apolipoprotein E (ApoE) ??4 allele), lifestyle (BMI of less than 18.5 and lack of alcohol consumption), comorbid vascular conditions (internal carotid artery thickening, angina, coronary artery bypass surgery, stroke, following website and peripheral artery disease), evidence of brain abnormalities shown by magnetic resonance imaging (white matter diseases or enlarged ventricles), cognitive test scores, and physical performances [34,35]. The combined effect of genetic-environmental or environmental-environmental joint exposures may also lead to the attenuation of the dementia risk. Population-based studies suggest an effect modification for the ApoE ??4 allele, the most important genetic risk factor for sporadic AD.
ApoE ??4 carriers seem more vulnerable to risk factors like alcohol drinking, smoking, physical inactivity, and high intake of saturated fat, indicating that people with genetic susceptibility may reduce their initial AD risk by lifestyle interventions (that is, physical activity, sufficient intake of PUFA, and avoiding excess alcohol drinking and smoking) [36]. Furthermore, it has been shown that high education may reduce dementia risk among ApoE ??4 allele carriers [37]. In regard to the interactions among modifiable risk factors, results from the Kungsholmen Project suggested that complexity of work with data and people was related to a decreased dementia risk and that the highest level of work complexity may modulate the increased dementia risk due to low education [23].
In conclusion, even though for some risk and protective factors the role in dementia and AD needs to be clarified, evidence from observational studies points at different modifiable factors that can be managed in order to prevent or delay dementia onset. Moreover, epidemiological findings strongly suggest that the life-course approach model and the multifactorial nature of dementia and AD should be considered when planning any preventive strategy. Prevention of dementia: current evidence from interventional studies Interventional studies on dementia and AD prevention have tested different medications, including statins, antihypertensive drugs, estrogens alone or in combination with progestin (hormone replacement therapy, or HRT), non-steroidal anti-inflammatory drugs (NSAIDs), and nutraceuticals (folate, Ginkgo biloba, and vitamins B12, C, and E).
For all of these compounds, the GSK-3 protective effects suggested by observational studies have sellekchem not been confirmed in randomized controlled trials (RCTs), the results of which are inconsistent or even suggest a detrimental effect on cognition (for example, NSAIDs and HRT) [38-41]. Few interventional studies implementing non-pharmacological approaches have been carried out.
Preliminary reports from animal models suggest that thiamine defi
Preliminary reports from animal models suggest that thiamine deficiency and direct alcohol neurotoxicity produce similar brain effects. These include loss selleck chemical of cells in the basal forebrain, hippocampal acetylcholine hypofunction, and shrinkage of frontal grey and white matter, with thiamine deficiency characterized by additional lesions in the diencephalon [27]. Vetreno and colleagues [27] suggested that the interaction between ethanol and thiamine deficiency does not produce more behavioral or neural pathology, with the exception of reduced white matter, than long -term thiamine deficiency alone; however, synergic effects have been noted elsewhere [28].
Notably, pure cases of thiamine deficiency, unaccompanied by chronic and excessive alcohol consumption (such as in cases of malnutrition), show a low rate of progression to KS [29], giving credence to the idea that an interaction of causative factors is responsible for the lasting cognitive deficits seen in alcohol-related disorders. How much is too much? The relationship between the amount of alcohol use and cognitive outcomes is complicated by differing definitions of drinking levels in the literature, and this complication relates in part to the varying definitions of a 'standard drink' from country to country. For example, a standard drink in the United Kingdom contains a relatively low 8 grams of alcohol, compared with 10 grams in Australia, 14 grams in the US, and 19.75 grams in Japan [30]. 'High' levels of alcohol consumption can range from 10 'standard' drinks a week [31] to more than 9 'standard' drinks a day [32].
Reduced frontal lobe volume has been associated with an amount of 418 grams a week but has not correlated with lower levels of consumption [14]. One review suggested that consumption of five to six drinks per day (which, by US standards, Anacetrapib equates to 70 to 84 grams) over extended periods results in 'cognitive inefficiencies', while consumption of 10 or more standard drinks a day manifests cancer as moderate cognitive deficits equivalent to that found in individuals with diagnosed alcoholism [33]. The differing elements of drinking patterns (for example, duration and severity of abuse, binge, and withdrawal periods) as well as difficulties gaining an accurate self-report of past drinking have further complicated attempts to link drinking levels to later cognitive impairment. Estimates of past drinking habits of individuals diagnosed with ARD have included up to 60 years of drinking (and up to 120 drinks a week at heaviest), although there is significant variability in length and severity of drinking [34].
6 In the next step, soft callus is gradually removed and replaced
6 In the next step, soft callus is gradually removed and replaced by mineralized bone matrix. The newly enough formed woven bone is called hard callus, is typically irregular, and needs to be remodeled.7 This repair stage represents the most active period of osteogenesis with high levels of osteoblast activity. In the remodeling phase the woven bone is transformed into lamellar bone with the trabeculae being formed along the pressure trajectories. The most active cells during remodeling are osteoclasts which demineralize the matrix and degrade the organic components by proteinases.7,8 New bone is laid down in its shape, structure and mechanical strength by osteoblasts.7 In summary, the first 1 to 2 weeks, in which inflammation and revascularization occur, seem to be most critical for fracture healing.
6,9 An early formation of granulation tissue could support the differentiation of mesenchymal cells into osteoblasts and thus provide a better requisite for bone remodeling. Coating of orthopedic implants aims at improved bone/implant contact (BIC), reduction of implant loosening and adverse reactions. Since the host response to surgical implants is mediated by regulatory interactions between the cells and the organic extracellular matrix,10-12 coating with components of the extracellular bone matrix (ECM) appears attractive to enhance bone healing around metallic and hydroxyapatite (HA) implants. Thereby, the ECM is not only a passive scaffold for cells.
Several components of the ECM like collagen type I (Coll), chondroitin sulfate (CS) or RGD peptide containing proteins are able to bind cytokines and growth factors12,13 and can interact with bone cells via integrins or other specific cell surface receptors14 thus directly or indirectly influencing migration and cell adhesion as well as proliferation and differentiation of these cells.15,16 Osseointegration is influenced by the primary stability (mechanical stability) and secondary stability (biological stability after bone remodeling) of the implant in the bone. Thereby early bone formation and apposition is essential for secondary stability.17 In this review the promotion of early bone formation by components of the ECM is described. Collagen Type I on Ti and HA Implants Collagen type I is the major structural protein in bone. Coating with Coll enhanced in vitro adhesion, migration and differentiation of osteoblasts on Ti disks.
18,19 Furthermore, the osteoconductive properties of Coll in cancellous and cortical bone are well documented.20-22 Coating of Ti pins with Coll showed that the cellular reaction on the implants appeared more intense around the Coll-coated implants in the early stages of bone healing in a rat tibia model compared with uncoated pins.23,24 At four days after implantation reparative granulation Cilengitide tissue was seen around the Coll-coated implants with 70% of the surface being surrounded by loose granulation tissue.
g , Wagenaar et al 2001) as well as in perceived social norms (e
g., Wagenaar et al. 2001) as well as in perceived social norms (e.g., Keyes et al. 2012) have been shown to contribute to changes in alcohol use. Of particular interest are historical full report shifts that relate to changes in developmental trajectories. Latent growth modeling analyses with multicohort data have demonstrated that, compared with earlier cohorts, more recent cohorts exhibit lower initial levels of binge drinking but more rapid increases from age 18 to young adulthood (Jager et al. 2013). This acceleration of alcohol use helps explain the findings that use among adolescents has been decreasing at faster rates than among young adults in recent decades. Figure Trends in alcohol use in the past 12 months and in having been drunk in the past 30 days for 8th, 10th, and 12th graders, 1991�C2011.
Predictors of Alcohol Use Among Adolescents Despite the changes in alcohol use that have occurred over the past three decades, the relevant risk and protective factors tend to remain very stable across historic time, age, gender, and race/ethnicity (e.g., Brown et al. 2001; Donovan et al. 1999; Patrick and Schulenberg 2010). Like many other large-scale studies on adolescent AOD use, the MTF study has cast a wide net in terms of risk and protective factors, correlates, and consequences of substance use. Not only is this approach well suited to placing alcohol use within the larger context of adolescent development, it makes good use of the MTF large-scale survey approach that emphasizes breadth of measurement.
Conceptually, the analyses drew from broad multidomain models when examining causes, correlates, and outcomes of adolescent alcohol use (e.g., Brown et al. 2009; Chassin et al. 2009; Maggs and Schulenberg 2005). This section summarizes MTF study findings concerning several domains of predictors of AOD use during adolescence, after considering methodological issues when examining causes and consequences of adolescent alcohol use. Methodological Issues in Understanding Risk Factors for and Consequences of Adolescent Alcohol Use When considering the correlates of AOD use, any attempt to discern whether these correlates are causes or consequences of substance use is hampered by three factors: Firm conclusions about causal connections are difficult without randomly controlled experiments.
Alcohol use during adolescence typically is reciprocally related to risk factors across development, such that problems that contribute to alcohol use may get worse with continued alcohol use (e.g., Cairns and Cairns, 1994; Dodge et al. 2009; Schulenberg and Maslowsky 2009). Factors that are identified as causes or as consequences of alcohol use during adolescence in the Entinostat total sample likely do not apply to all young people, given the heterogeneity in developmental course (Schulenberg 2006).
In order for the intercept to have a more meaningful interpretati
In order for the intercept to have a more meaningful interpretation, this variable was centred ('BMI – 25.77′). http://www.selleckchem.com/products/Abiraterone.html A limitation of the variable 'body mass index' is that it is based on reported height and weight and therefore less reliable compared to measured data [36,37]. The use of self-reported data results in an underestimation of BMI [37]. A second limitation of our data is the use of BMI as the sole criterion of excess weight. According to a number of studies [1,5,38], abdominal obesity is, apart from overall excess weight, an independent Inhibitors,Modulators,Libraries risk factor in type 2 diabetes. The accumulation of intra-abdominal or visceral fat is strongly associated with type 2 diabetes [5]. Physical activity We measured the concept of 'physical activity' by the variable 'population at risk due to a lack of leisure time physical activity' as defined in the manual of the Health Interview Surveys [35].
We relabelled this variable as 'lack of (leisure time) physical activity'. This is a dummy variable with the categories: weekly physically active (0) and sedentary [1]. The category 'weekly physically active' was taken as the reference modality. A restriction of this indicator is that it does not take physical exercise during Inhibitors,Modulators,Libraries professional ac-tivity into account. As a consequence, it is strongly socio-economically related. Persons with a lower education more often have sedentary leisure activities. A second limitation of the variable 'lack of (leisure time) physical activity' is that it is culturally related. In the Turkish and Moroccan culture, there is no tradition of leisure time physical activity, especially not for women [28].
Results Inhibitors,Modulators,Libraries We start by comparing the prevalence of diabetes in the Turkish and Moroccan communities in Belgium with the prevalence in native Belgians. Subsequently, we examine a number of explanations for the higher diabetes prevalence in Belgians of Turkish and Moroccan origin. The focus will be on lifestyle factors – excess weight/obesity and lack of physical activity – and socio-economic determinants – educational attainment Inhibitors,Modulators,Libraries and income. Diabetes prevalence As expected, Figure Figure11 shows that the prevalence of diabetes in our sample increases with age [1,5]. At age 25, the risk of diabetes in native Belgians is 0.006. In 25-year-old Inhibitors,Modulators,Libraries Belgians of Turkish origin, the risk of diabetes is 0.023. In Belgians of Moroccan origin of the same age, the risk of diabetes amounts to 0.
017. At age 70, the mean diabetes probability has increased to 0.122, 0.362 and 0.297 in native Belgians, Belgians of Turkish origin and Belgians of Moroccan origin respectively. The diabetes prevalence is higher at all ages Brefeldin_A in Belgians of Turkish and Moroccan origin than in native Belgians [14,15,19-21]. Finally, Figure Figure11 reveals that type 2 diabetes has an earlier onset in the Turkish and Moroccan communities in Belgium. Kriegsman et al.
These all lead to greater efficiency and productivity Header hei
These all lead to greater efficiency and productivity. Header height control selleck bio has been a challenging issue in industry for decades, and hence limited harvesting speeds have occurred as a result. Fig. 2 Schematic of feedback header height control While relevant, this control problem Inhibitors,Modulators,Libraries has received relatively little attention from the research community. Early approaches of feedback control were proportional-type controllers with an input dead zone operating around the Inhibitors,Modulators,Libraries set-point [3]. One of the few recent investigations to utilize modern control techniques introduced a linear quadratic Gaussian controller to automatically track changing terrain shapes [4]. Another reduced order state feedback controller was proposed by using a sky hook damper to simplify an optimal full state feedback controller and reject the output disturbance [5].
The feedback control in Refs. [4] and [5] works well in simulation at relatively low frequencies: below 1 Hz. Field tests illustrate that the achievable bandwidth of a header height Inhibitors,Modulators,Libraries control system is usually much lower in practice [6]. However, to increase the working efficiency and obtain desired header height control performance at the same time, a closed loop bandwidth well above 1Hz is demanded by modern machines. This closed loop bandwidth is desired to accommodate terrain variations resulting from combine forward motion as depicted in Fig. Fig.1.1. For a desired vehicle speed of approximately 7 miles per hour, which is at the upper limit of current harvesting speeds, the desired closed loop bandwidth specification is 3Hz or better.
In this article, the authors explore and explain the fundamental causes of the bandwidth limitations Inhibitors,Modulators,Libraries in Inhibitors,Modulators,Libraries the feedback control of the header height system. The rest of paper is organized as follows. Section 2 introduces the models for the combine system shown in Figs. Figs.11 and and2.2. The two subsystems that are most relevant to the control limitations are presented: (i) the mechanical subsystem and (ii) the hydraulic actuation subsystem. Section 3 utilizes the models of Sec. 2 and presents an analysis explaining the performance limitation. Section 4 verifies the model and validates the limitation analysis. A conclusion provides a summary and offers System Modeling?insight as to possible remedies that could be undertaken. 2. 2.1. Mechanical Subsystem Modeling.
Underactuated GSK-3 systems are those that possess fewer numbers of actuators than the number of degrees of freedom (DOFs). Assume an underactuated manipulator has n independent DOFs, m of which are actuated, and the remaining l=n?m DOFs are termed passive. As illustrated in Ref. [7], the corresponding n generalized coordinates can be written as qT=(q1T,q2T), where q1��Rl and q2��Rm correspond to the passive DOFs and active DOFs, respectively.
The tissue obtained was fixed in 10% of neutral buffered formalin
The tissue obtained was fixed in 10% of neutral buffered formalin, and processed routinely. The sections stained with Hematoxylin and Eosin revealed cystic spaces lined by a papillary epithelial proliferation which was bilayered. The cells of the epithelial lining appeared intensely eosinophilic. At the core of papillary projections a variable amount of lymphoid tissue with mature lymphocytes was selleck Lapatinib observed [Figure 5]. Figure 4 Tumor after superficial parotidectomy Figure 5 Microscopic picture (��10) The patient did not present with any post-surgical complications. The patient is under regular follow-up to check recurrences, if any. DISCUSSION The most accepted hypothesis about the origin of WT is that it develops from salivary duct inclusions in the lymph nodes, after the embryonic development of the parotid gland.
This hypothesis is further supported by the frequent detection of salivary gland tissue in the peri- and intraparotidal lymph nodes. In the parotid region, lymph nodes are occasionally noted to have oncocytic and papillary changes. On the other hand, the tumors presenting epithelial differentiations similar to those observed in WT develop outside lymph nodes and have no lymphoid stromal component[8]. Benign tumors have only rarely been associated with cigarette smoking, which focuses attention on the nature of the underlying neoplastic process and how it may differ from other benign tumors. Although generally believed to be an adenoma, WT, as suggested by Allegra, may be a delayed hypersensitivity reaction.
[9] An interesting fact that caught the attention of the pathologists is that a decline in the incidence in men and a concurrent increased incidence in women has been observed in recent years. The change is probably due to decline in the smoking habit in men and a reverse trend in women.[10] The increased frequency of adenolymphoma has been ascribed to the association of adenolymphoma with smoking and the proportional increase in female smokers.[11] Studies conducted among atomic bomb survivors suggest that radiation may also be implicated in the tumorigenesis. An earlier claim of a strong association with Epstein�CBarr virus (EBV), because of the EBV�CDNA found in tumor cells in some studies has not been substantiated.[5] Clinically, WT occurs almost exclusively in the parotid glands, in its superficial lobe and rarely in the deeper lobe (10%).
[5] The other preferred locations Dacomitinib include the buccal mucosa, submaxillary gland, lip and palate.[12] The patients can be asymptomatic or can have facial pain, rarely, facial nerve palsy may be seen in tumors associated with inflammation and fibrosis, which can be mistaken for malignant tumor. Ipsilateral earache, tinnitus and deafness are uncommon ear symptoms that might be seen in some patients.


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UK ponders a Digital Rights Agency
The British Intellectual Property Office on Friday published a discussion paper asking the public for input on whether their might be a useful role for a new, industry-backed Digital Rights Agency in reducing illegal file-sharing as well as facilitating the development of legal online services. The 29-page paper (PDF) is presented as a "straw man," meant more as a conversation-starter than as a concrete set of proposals. Yet it's also of a piece with a separate, formal consultation underway in Britain on proposed legislation to require Internet service providers to warn file-swappers identified by their IP addresses that their activity is illegal.
Since the new report raises the question of ISP liability–and a possible role for a new non-governmental agency in enforcing it–it's bound to spark controversy. But it would be a shame if that were to become the sum total of the discussion around it because the text of the report suggests two key, related insights on the part of its authors that, in Media Wonk's view, can't be emphasized enough in trying to figure out how to respond the collision of creative works and digital networks.
The first key insight is the recognition that Web tends to reward enablers more than publishers, and that business models might be more workable if they were focused at the application level rather than at the content itself.
By itself, "content" has little market value on the Internet because scarcity — the traditional pillar of value for creative works — is so hard to maintain. Content becomes valuable on the Internet when people are able to access and make use of it in ways that are valuable to them, regardless of its scarcity or ubiquity. As a result, the players best positioned to capture a portion of that value are often the technology providers who enable that access and use.
Here's what the report says on that point:
The old business models suited to the analogue environment are not set up to exploit these new markets. Whilst there is a plethora of new offerings only a very few have gained significant traction, and it is not yet obvious there the value that consumers undoubtedly set on creative content can be extracted and therefore who can monetise it. New players are now part of the creative value chain – ISPs, search engines – and may end up being better placed to develop the customer relationship or exploit the advertising potential from driving traffic than those creating and producing the content itself.
In the old analogue and physical world a lot of the value in creative content is protected by restricting where and when it can be accessed. For example, windowing and regional coding in the film industry aims to control who can access content at a given time in a given place and to direct the value of that access to specific parts of the value chain.
But that model is increasingly irrelevant online. Consumers are no longer prepared to be told when and where they can access the content that they want.
Like Willie Sutton explaining why he robbed banks ("because that's where the money is") if I were a content owner I'd be looking to go where the value is: at the application level. I'd be trying to get to a point where I could put all my content behind an API, or a series of APIs. I'd publish the API spec, provide a guide to the structure of my metadata, and say to service providers and application developers, "come and get it."
Build any application you want (within reason) to make use of my content, and I'll license you the API that lets your application access it. I would put certain terms and conditions on the continued use of the API — such as not building an application that allowed someone to go into competition with me by providing my own conten t– but if there's a problem, and a dispute arises, it would be a simple contractual issue. No need to get into a debate over fair use or the constitutional limits of copyright and the rest of it. Just license my API, monetize your service or application as you will, and pay me my fee.
Far, far easier said than done, I know. But it leads to the second, key insight I see reflected in the report: the notion of market failure, or at least market inefficiencies.
Anglo-American copyright (as opposed to the Continental variety) has always been fundamentally utilitarian. The exclusive rights embodied in our copyright law do not exist for their own sakes but to establish the conditions in which markets can develop for creative works, as a way of incentivizing creativity. Such markets could be for individual copies of a work, or for access to a performance of a work, or for licenses to others to exploit those rights. But the premise and goal was always markets.
That mechanism isn't working very well right now, however, in part because of the fundamental incompatibility between digital networks and exclusive access. The licensing of creative works for use on the Internet is extraordinarily complex — as any would be music service provide can tell you — in part because of the large number of different exclusive rights, controlled by different rights owners and administered by different agencies for a single work.
Regardless of whether all of those exclusive rights and the mix of compulsory and voluntary licenses around them are justified or fair in their own right, their complexity has become an impediment to the creation of efficient markets for the works themselves, rather than establishing the conditions for efficient markets.
From the point of view of utilitarian copyright law they very nearly defeat their own purpose.
One of the proposed roles of the Digital Rights Agency discussed in the British report, then, is to provide a venue for the various stakeholders to work together, in a non-adversarial way, to devise new market modalities.
From the report:
It is very difficult for business to compete on the basis of pay models with "free" and "easy," even if that free and easy is also unlawful. We have nevertheless seen innovation in the content industries over recent years. Increasingly it is possible to get legal access to popular content from a variety of sources. But it is against a background of ever growing illicit copying. So there is a real challenge for all who want the content markets to flourish, and to safeguard the viability of investment in creativity in the future, to come together to work out how to move forward. It is not Government's job to mandate how rights are traded or used, but we should look at whether we can facilitate a market space where it would be simpler and easier for commercial and free negotiations to take place. For the consumer, "inexpensive (or apparently 'free') and easy and legal" can be an effective substitute for "free, easy but unlawful". We need to encourage rights owners to develop business and distribution models that meet those consumer needs and fund the creation of future content.
[…] Put at its most ambitious, our vision for a rights agency is to facilitate a major change of approach across the whole value chain as to how content is provided, packaged and sold to consumers. Business models need to develop that are not only sustainable but that provide real opportunities to build the successful businesses of tomorrow.
I know. A lot of weight to put on a bureaucratic missive. But it's worth a read, as much for the questions it raises as the solutions it proposes.
If nothing else, it beats arguing over whether a download is both a reproduction and a performance, or just one of them.
Boxee vs. Comcast: An authentic dispute
The Iger sanction


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What Is Public Interest Law?
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The term intergovernmental organization (IGO) refers to an entity created by treaty, involving two or more nations, to work in good faith, on issues of common interest. In the absence of a treaty an IGO does not exist in the legal sense. For example, the G8 is a group of eight nations that have annual economic and political summits. IGOs that are formed by treaties are more advantageous than a mere grouping of nations because they are subject to international law and have the ability to enter into enforceable agreements among themselves or with states.
View our International Public Interest Work FAQ
The main purposes of IGOs were to create a mechanism for the world's inhabitants to work more successfully together in the areas of peace and security, and also to deal with economic and social questions. In this current era of increasing globalization and interdependence of nations, IGOs have come to play a very significant role in international political systems and global governance.
IGOs cover multiple issues and involve governments from every region of the world, including offices in the U.S. Among the oldest IGOs are the United Nations, which replaced the League of Nations, the Universal Postal Union, and the North Atlantic Treaty Organization (NATO). The Universal Postal Union, founded in 1874, is currently a specialized agency of the UN. Other well-known IGOs are the European Union (EU), the Organization of Petroleum Exporting Countries (OPEC), the African Development Bank (ADB) and the World Trade Organization (WTO).
Since the creation of the UN and NATO, IGOs have become essential actors in the international community. Additionally, as many IGOs, such as the UN and the EU, have the ability to make rules and exercise power within their member countries, their global impact continues to increase.
Types of IGOs
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Although South Carolina is the 26th most connected state and despite the fact that there are 61 broadband providers in the state, there are still 23,000 people in the state with no access to broadband. No cable. No DSL. No fixed wireless. No mobile internet. Nothing.
Of the 4.8 million South Carolinians, 969,000 have access to only one wired provider. Of course, that means ISP (internet service provider) can old them hostage, raise rates, or alter the terms and conditions of their contract. Because those people have no competitive options). 133,000 people in the state suffer with low data caps with their home internet connection because they must rely on fixed wireless or mobile broadband connections.
The state's overall poverty rate is 18.6%. Its child poverty rate is an absolutely horrifying 27%. Its senior poverty rate is 14%. Its senior poverty rate is 14%. And its extreme poverty rate is 8.4%.
Unfortunately, none of the FCC's Lifeline Broadband Pilot Programs were conducted in South Carolina.
Orangeburg County Broadband currently serves public facilities, but a recent proposal says, "Our intention is to offer an IP voice service, IP over the top video service, and High Speed Internet. For residents initially served by Fixed Wireless we will offer IP voice and High Speed Internet, no video offering will be available to residents served by wireless." Currently, about 300 customers have access to the Internet as a result of the initial phase to supply Orangeburg County residents and businesses with high-speed Internet access.
I live in the Rains SC community, but our e911 address is Mullins. We want the Internet down here, I am disabled, there is a Business cross the road in front of my house and they try to say that ATT us not here but that's a lie.that company has Att. And we hear in this community need the Internet for our kids to do homework. Why is it so hard to get internet in a rural commnity? We don't want Hughesnet that charge families so much money, they have been saying that Spectrum was coming to the area, but the past 5yrs nothing has happen, we need the Internet bad in this area please help.
Here's a basic lesson in cable TV/internet economics, Edith. If a cable company lays 1000 feet of cable in a city, it may bring internet service to hundreds of homes. If they lay the same 1000 feet of cable in a rural area, it may reach only one home. Therefore, they can afford to lay the cable in the city, but not in the rural area. That's why rural service is so spotty.
The eligibility rules are different for each of the plans, Cheryl. Click on each of the plan names in this article and you will find the rules and contact info to apply.
I live in Myrtle Beach, SC..I have HTC for phone, I have life line on my phone,, do I qualify for the internet??
I would like to know if ISP providers would be encouraged to assist the City of Sumter with providing the same services that Orangeburg has developed so many more low income families could have low cost internet access. Are their providers in Sumter County SC.
We are unable to track availability down to such narrow local areas, Kevin. The problem is that one service provider may cover one side of the street while another service provider offers service on the other side. But you can go through the list of low-income service providers, check which ones offer service in cities near you, and contact their customers service teams to see if they are available in your area.
If you're lucky, PCs for People covers you area. We recommend its service very highly.
I'm a senior and I can't afford paid tv. I have free tv with the adapter.
I have straight talk house phone.
I would like cheap internet.
I am inquiring on behalf of a friend who lives in Chester S.C. She & her mother are living on a limited income & does receive SNAP benefits. She is working part-time has no means of transportation & her mother is disabled. My friend is trying to complete nursing school & on-line availability for course work as well as job searching etc. is a must for her. I told her that I would investigate for her on free or low-cost wifi internet in her area. She would prefer free but could afford up to $10/mo. max. Could you help me help her?


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Saint Vincent Archabbey
Sunday Homilies
Home > News > 2012 News > Final Ruling in the Case of Rev. Mark Gruber
Final Ruling in the Case of Rev. Mark Gruber
2012 News News
249Comments Off on Final Ruling in the Case of Rev. Mark Gruber
The Vatican Congregation for the Doctrine of the Faith (CDF) has issued a final decision in the case of Rev. Mark Gruber, O.S.B. This case stems from the July 2009 discovery of pornographic images on the computer assigned to Rev. Gruber by virtue of his teaching assignment.
As required by civil law, because of the nature of the images, Saint Vincent officials reported the matter to civil authorities. Rev. Gruber was relieved of his teaching assignment and placed on leave from all exercise of public priestly ministry. As required by Church law, a detailed account of the matter was reported to the CDF in November 2009. The CDF is the Vatican office which has jurisdiction over cases involving grave offences against the Catholic faith, the sacraments, and serious moral offences. Rev. Gruber was afforded the opportunity to respond personally and through canon law advocates of his choosing.
The CDF reached a decision in the case on June 30, 2011. Recourse (appeal) was made against this decision. After considering all of the arguments made on appeal by Rev. Gruber and his canonical advocates, the CDF reached a final decision on June 27, 2012. The decision was approved by His Holiness Pope Benedict XVI on June 30, 2012.
This final decision of the CDF is set forth in a decree issued on July 2, 2012. It confirms that Rev. Gruber has been found guilty of the delicts (canonical crimes) of possession of child pornography; production of materials which gravely injury good morals; abuse of the Sacrament of Confession (but not a violation of the sacramental seal); and defamation of a legitimate superior. These delicts are defined according to the doctrine and norms of the Church.
Accordingly, the CDF rules that Rev. Gruber must live the remainder of his life in prayer and penance outside of St. Vincent Archabbey in a religious community to be determined by the CDF. He may not leave an assigned residence without prior authorization. He is permanently prohibited from exercising any public priestly ministry, including the celebration of the sacraments and teaching. Rev. Gruber is not to have any contact with minors under age 18, and he may not have access to any computer without strict supervision. Rev. Gruber is prohibited from presenting himself as a cleric in public.
No further recourse (appeal) may be made against this decision of the CDF. Failure to comply with the permanent restrictions imposed on Rev. Gruber by the CDF may result in further penalties.
The final decree in this case has been communicated to Rev. Gruber, to Archabbot Douglas R. Nowicki, O.S.B., of St. Vincent Monastery in Latrobe, Pennsylvania, and to Bishop Lawrence E. Brandt of the Diocese of Greensburg, Pennsylvania.
Because of widespread speculation and questions concerning the facts of this case, the final decision of the Congregation for the Doctrine of the Faith has been disclosed in order to avoid any further misunderstanding.
Nineteenth Sunday in Ordinary Time
Twentieth Sunday in Ordinary Time
SVA PR
Three Ordained To Diaconate April 25
April 29, 2015 May 30, 2019 SVA PR
Enters Novitiate at Saint Vincent Archabbey
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text:
The advantages that the Corner Shot® offers to a SWAT OPERATION lay in two main areas: "The Operator" and "The Operation Management." Advantages for the Operator are those that the officer or soldier carrying the Corner Shot® experiences. These advantages are the following:
The Operator can engage a target located behind a corner without exposing himself. The Corner Shot® can save his life.
The Corner Shot® can be used as an "extension" to the user's eye. It allows the Operator to see over high objects and under raised objects quickly and efficiently.
The Operator shooting accuracy increases due to the Corner Shot®'s laser guided camera aim.
Advantages for Operation Management are those that the Central Command experiences due to the use of the Corner Shot® being carried by the Operator. These advantages are the following:
Central Command receives a live video feed of what is happening at the front line. This leads to better understanding of the situation and can improve decision-making.
By using an additional screen the officer or soldier located behind the Corner Shot® Operator can see the same view that the Operator is seeing on the Corner Shot® screen. This enables him to better support the Operator and improves coordination.
The Corner Shot®® can be set up to facilitate recording of the Operator's screen. That means that all Target Engagements are documented. This is an effective tool to be used for legal and training purposes.
Corner Shot® can change the nature of relevant operations by providing security forces with an effective tool to accurately pinpoint and engage a target, at minimal risk to their personal safety.
Amos Golan, the inventor, one of Corner Shot's founders and a former Anti-Terror Unit Commander, said: "I believe that the Corner Shot® weapon system can be extremely beneficial in the global war on terror. It protects soldiers' lives and increases their chances of survival, while drastically improving their ability to gather information and transmit the combat scenario as well as pinpoint and engage targets out of their line of sight." He added: "Today's combat situations, especially in low intensity conflicts, involve fighting in urban terrain, and inside inhabited buildings, forced entry into airplanes, buses or trains. This unnecessarily exposes security forces to the enemy and presents an immediate risk to their lives. Corner Shot® removes the need for this initial exposure."
"The Corner Shot® system is designed in a way that enables security forces to engage targets from the left, and right, from the front, up or down, and to move to each of these shooting positions very rapidly without the removal of hands from the weapon. This shortens reaction time and increases accuracy in sudden engagement situations. The weapon system can be triggered completely from behind cover."
"Today's combat situations, especially in low intensity conflicts, involve fighting in urban terrain, and inside inhabited buildings, forced entry into airplanes, buses or trains. This unnecessarily exposes security forces to the enemy and presents an immediate risk to their lives. Corner Shot® removes the need for this initial exposure"
Amos Golan


Beautiful new branding project for The Passage by SDCO Partners. An elegant green combined with a with a sleek uppercase logotype and minimal thoughtful layout, make this luxury living brand an eyecatcher. Our personal highlight are details used in the printing technique such as embossing and foil printing.


text:
UEFA Women's Champions League roundup: Heath, PSG out; Wolfsburg sets new mark
By Richard FarleyOct 16, 2013, 7:33 PM EDT
One way or another, prominent Americans were going home. In the home side at Charlety in Paris were Tobin Heath and Lindsay Horan, the duo hoping to see Paris Saint-Germain overcome their 2-1 deficit and make UEFA Champions League's Round of 16. To do so, however, they would have to end the season of Christen Press, Ali Krieger, and the rest of the American contingent from Sweden's runners up, Tyresö. One team would leave eliminated by the round's least favorable draw.
Heath, Press, and Krieger weren't the only prominent names visiting Paris on Wednesday. Tyresö, having aggressively targeted American signings this summer, also started U.S. internationals Whitney Engen and Meghan Klingenberg. Washington Spirit goalkeeper Ashlyn Harris was in goal, while former Women's Professional Soccer Most Valuable Players Marta and Verónica Boquete featured in attack. A fan of the women's professional game in the U.S. would have recognized most of Tony Gustavsson's starting XI.
That star power was the result of a summer buildup that was questioned when the then-Damallsvenskan leaders risked their winning formula to bring in the likes of Krieger, Harris and Engen, but against a PSG side that's spent big to bring in Heath, Horan (among others), it'd be needed. French internationals Laure Boulleau, Laura Georges, Marie-Laure Delie were also in today's lineup, joining a foreign contingent German defender Annike Krahn and Swedish attacker Kosovare Asllani.
These teams too talented to be meeting in the first round (Round of 32), a contention undermined by the reality of Wednesday's game. There they were, two of the more talented teams in Europe, about to see one eliminated at step one of the process. Had they been draw against other clubs, each would be threats to make the semifinals. Instead, one of them was going home three rounds earlier, that club's big spending set to go for naught.
With those stakes, it's no surprise the tie's second leg played out as a cagey affair, the visiting Swedes playing as if a clean sheet was their best hope. Despite the presences of Marta, Press, and Boquete, Tyresö would only put two shots on Karima Benameur, finishing the match outshot 13-6.
It was indicative of the type of control PSG exerted, twice seriously testing whether Harris could protect Tyresö's slim edge. One slip, and the roles would be reversed, PSG left to decide whether to defend their away goals edge of press for insurance. When the match hit intermission scoreless, it still seemed like a matter of time before PSG turned those tables.
Ashlyn Harris, seen here playing for the U.S. Women's National Team, had five save for Tyresö today in Paris. (Photo: AP Photo.)
Yet as the second half ticked away, Farid Bensetti's side never found a way through. They made changes, taking off Asllani, Heath and Jessica Houara in favor of Linda Bresonik, Kenza Dali, and Horan. They forced 10 corner kicks and generally controlled the match. But unable to unlock an opponent readily sacrificing attacking verve for defensive zeal, Paris Saint-Germain were left with the what if. The 0-0 result made Tyresö 2-1 aggregate winners.
For team that's signing players to six-figure deals, it's a bitter pill to swallow, particularly given their control of the match. Yet PSG's is a long-term ambition. They may have thought themselves capable of making noise in this year's competition, but their domestic tests against superpower Lyon showed they're still progress to be made.
Unfortunately for them, however, this result means the few tests they'll get against OL will be the only time they face Champions League-caliber competition for the rest of this year. The biggest challenge remaining in their season isn't progressing in Champions League; it's preventing Juvisy or Montpellier from claiming their place in next year's tournament.
For Tyresö, however, their investment is starting to pay off, even if the shakeup may have cost them a league title (Malmö has clinched the Damallsvenskan title). Though there's no guarantee things will be easier for them in the Round of 16, Marta, Boquete, and the team's contingent of Americans can move forward knowing they're capable of knocking off teams with PSG's firepower.
Here are the rest of the day's results:
38-year-old Patrizia Panico, seen here playing for the Italian national team, scored as Italian champions Torres advanced on Wednesday. (Photo: Getty Images.)
Torres (Italy) 3-1 Spratzern (Austria); Torres advances, 5-3 aggregate: This one was more lopsided than it looks, with first half goals from Swiss international Sandy Mändly and 38-year-old icon Patrizia Panico putting Spratzern on the ropes early. The Austrians finally got on the board in the 84th minute through forward Lisa Makas, but by that time, they were three goals down and still hadn't reversed Torres's edge in away goals.
Birmingham City (England) 1-0 PK-35 (Finland); Birmingham City advances, 4-0 aggregate: The Blues start to make amends for last year's early exit after finishing off Finland's champions, with last week's lopsided result in Vantaa taking the drama out of today's second leg. Despite only getting a goal from Chelsea Weston in the 50th minute, Brum outshot their guests 21-3, preventing PK-35 from recording a shot on goal.
Zorky (Russia) 4-1 Thór/KA (Iceland); Zorky advances, 6-2 aggregate: Three goals over a 13-minute span of the first half took the life out of this one, with midfielder Elena Morozova (22′) , Ukraine's Vira Dyatel (24′) and American Nick Astley (34′) putting Zorky up 5-1. The teams traded second half goals, with Zorky's coming from Chicago Red Star midfielder Alyssa Mautz.
Wolfsburg (Germany) 13-0 Pärnu (Estonia); Wolfsburg advances, 27-0 aggregate: It's a growing competition. Much like when the World Cup started expanding its field, when a couple of tournaments forced teams to take their lumps, this is short-term pain for long-term gain. This particular pain represents a new tournament record, with Washington Spirit forward Connie Pohlers adding three more goals to her personal competition high mark.
Brønby (Denmark) 2-2 Barcelona (Spain); Barcelona advances on away goals, 2-2 aggregate: After being held to a scoreless draw last week in Catalonia, Barça's progress in the women's game look set to be stunted, something that was affirmed when Anja Thorsen put the Danes up after 25 minutes. The second half, however, saw the Spanish champions convert on the two shots they put on Jenny Olsson. Marta Corredera's 52nd minute equalizer gave the visitors an away goals edge, while 18-year-old Serbian international Jelena Čanković left Brønby chasing miracles after her 87th minute goal. Four minutes into stoppage time, Boye Sørensen pulled the home side even, but away goals see them out of the competition.
Fortuna (Denmark) 2-0 Tavagnacco (Italy); Fortuna advances, 4-3 aggregate: Camilla Larsen's 32nd minute opener equalized for Fortuna, making the two goals recorded last week in Italy potentially decisive. When Romanian Laura Rus added insurance in the 81st minute, the Danes were into the Round of 16.
German international Anja Mittag, seen celebrating her country's victory at Euro 2013, scored twice for Malmö on Wednesday. (Photo: Getty Images.)
Malmö (Sweden) 5-0 LSK (Norway); Malmö advances, 8-1 aggregate: German international Anja Mittag posted a first half double, Dutch starlet Manon Melis scored in the 21st (and 84th) minute, while Swiss star Ramona Bachmann completed the first half assault. The hosts up 4-0 (7-1) by the 34th minute.
Turbine Potsdam (Germany) 6-0 MTK (Hungary); Potsdam advances, 11-0 aggregate: Three players, three doubles, all within the match's last half-hour: Japanese striker Asano Nagasato scored in the 62nd and 92nd minutes; 19-year-old Macedonian midfielder Natasa Andonova added goals in the 63rd and 88th; and Swedish midfielder Antonia Göransson recorded hers in the 65th and 84th minutes. Potsdam outshot MTK 49-4.
Neulengbach (Austria) 1-1 Apollon (Cyprus); Neulengbach advances, 3-2 aggregate: FC Kansas City's Sinead Farrelly, one of six Americans starting for Apollon, pulled the Cypriot side within one in the 77th minute, but a 58th minute goal from 22-year-old Slovakian Alexandra Bíróová held up, sending the most U.S.-friendly club out of the tournament.
Lyon (France) 6-0 Twente (Netherlands); Lyon advances, 10-0 aggregate: Lotta Schelin and Megan Rapinoe added goals from the bench, though by the time they were brought on (46′, 59′), Twente were already chasing six. Lartitia Tonazzi and Louisa Necib had the hosts up two at halftime, while Élise Bussaglia and Eugénie Le Sommer doubled their team's lead before Schelin and Rapinoe made their contributions.
Sparta Praha (Czech Republic) 1-1 Zürich (Switzerland); Zürich advances, 3-2 aggregate: 16-year-old Mirjine Selim's early strike not only gave Zürich valuable insurance but also pulled back the goal they conceded at home in leg one. Iva Mocová's second half score gave the Czechs life, but the hosts were never able to mount the pressure needed to pull back the final goal.
There are four more Round of 32 deciders tomorrow:
Rossiyanka (Russia) return home with a 4-2 edge over Spartak Subotica (Serbia);
Konak Belediyesi (Turkey) try to protect their 2-1 lead against Unia Raciborz in Poland;
Glasgow City (Scotland) return home having earned a 2-2 draw at Standard Liege (Belgium);
and Arsenal (England) hold a 7-1 edge over Kazakhstan's CSHVSM-Kairat.
The Round of 16 matchups have already been drawn, with matches to begin the second week of November, with Germany's teams both drawing tough matchups:
Barcelona vs. Zürich
Konak/Urai vs. Neulengbach
Fortuna vs. Tyresö
Spartak/Rossiyanka vs. Torres
Turbine Potsdam vs. Lyon
Zorky vs. Birmingham City
Malmö vs. Wolfsburg
Kairat/Arsenal vs. Standard/Glasgow
Follow @richardfarley


It's Boris Karloff as "The Mummy"! He's 2'x3′ airbrushed acrylic on canvas.
Also got started on another- Jack from "The Shining". He'll be the same size- 2'x3′.
Should get this done tonight, and hope to get at least 1-2 more done by Thursday night when we hang the show.
Don't forget- the art show is this Friday from 6-10pm.
← New direction for Memphis?


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