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Internet Directory - Top : Regional : Europe : United Kingdom : Arts and Entertainment : Radio : Regional and Local
Top : Regional : Europe : United Kingdom : Arts and Entertainment : Radio : Regional and Local (146 web sites)
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Restricted Service Licences
102 Town FM
Adult contemporary/gold station for Ipswich. Includes news, local events and photo gallery. Available on FM and web stream.
http://www.town102.com/
102.5 Radio Pembrokeshire
Contemporary and classic hits for Pembrokeshire. Includes local news, station, programme and presenter details. Available on FM.
http://www.radiopembrokeshire.com/
103.4 Sun FM
Chart hits and oldies for Sunderland and Wearside. Community information including entertainment listings, business directory and regional news, plus station listings and information. Available on FM.
http://www.sun-fm.com/
107 Star FM
Adult contemporary and classic hits for Cambridge and Ely. Station, shows and presenter information, gallery and sales information. Available on FM.
http://www.star107.co.uk/
107.8 Arrow FM
Classic hits for Hastings. Includes presenters, gallery, schedule, local news, sport and weather.
http://www.arrowfm.co.uk/
107.8 Radio Jackie
New and classic hits for Kingston-upon-Thames. Presenter profiles, advertising, schedule and station history. Available on FM and live web stream.
http://www.radiojackie.com/
Classic and current hits for Burnley and Pendle. News, weather and presenter information. FM and on-line.
http://www.2br.co.uk/
96.4 The Eagle
Adult contemporary music for Guildford. Includes gallery, programme and advertising information. Available on FM.
http://www.964eagle.co.uk/
96.7 West FM
Hit music for Ayrshire. Features presenters, programmes, chart, galleries, news, chatroom and forum. Available on FM, DAB and live web stream.
http://www.westfm.co.uk/
97.2 Stray FM
Adult contemporary and chart music station for Harrogate, Knaresborough and Ripon. Community information including entertainment listings, business directory and regional news, plus station listings and information. Available on FM.
http://www.strayfm.com/
Serving Greater London with news, sport, entertainment and travel. Available on FM, DAB and live web stream.
http://news.bbc.co.uk/local/london/hi/tv_and_radio/
BBC Radio Cymru
Welsh speaking music and talk network covering Wales. Available on FM, DAB and live web stream.
http://www.bbc.co.uk/radiocymru/
BBC Radio Foyle
Local programmes for Londonderry from BBC Radio Ulster. Available on FM, AM, DAB and live web stream.
http://www.bbc.co.uk/radiofoyle/
BBC Radio Scotland
News, information, talk and music for Scotland. Available on FM, AM, DAB and live web stream.
http://www.bbc.co.uk/radioscotland/
BBC Radio Ulster
BBC radio for Northern Ireland. Available on FM, AM, DAB and live web stream.
http://www.bbc.co.uk/radioulster/
BBC Radio Wales
News, information, music and talk for Wales. Available on FM, AM, DAB, cable, satellite and live web stream.
http://www.bbc.co.uk/wales/radiowales/
BBC Three Counties Radio
Information and music for Bedfordshire, Buckinghamshire and Hertfordshire. Station listings, information, history, tour and features. Available on FM and BBC iPlayer.
http://www.bbc.co.uk/threecounties/local_radio/index.shtml
BCB 106.6 fm
Bradford Community Radio. Includes schedules, podcasts, and web stream.
http://www.bcbradio.co.uk/
Big L 1395
Radio station, which plays music from the 50's to the present day. Available on AM, Sky Digital and live web stream. Site includes weekly new music chart plus station information.
http://www.bigl.co.uk/
Chart and contemporary hits for London. Station news and information, including music, presenters and shows, plus local news, sports, entertainment and events. Available on FM, DAB and live web stream.
http://www.capitalfm.com/
CityBeat 96.7
Adult contemporary hits for Belfast. Includes what's on guide, station information and programme guide. Available on FM.
http://www.citybeat.co.uk/
Clyde 1
Chart and contemporary hits stations for Glasgow. Local news and sports information, presenter profiles, scheduling and music section including Scottish chart. Available on FM, DAB and live web stream.
http://clyde1.com/
Easy listening station for Glasgow. Local news and sports information, music, station and presenter profiles. Available on AM, DAB and live web stream.
Connect FM
Classic hits and chart music for Kettering, Corby and Wellingborough. Includes on-air, music and events information. Available on FM.
http://www.connectfm.com/
Hit music for Northern Ireland. Includes schedule, music, playlist and presenter information, plus gig guide and local news, travel and sport. Available on FM.
http://www.coolfm.co.uk/
Downtown Radio
Chart and classic hit music station for Northern Ireland. Includes news, events, travel, schedule and playlist information. Available on FM, AM, DAB and live web stream.
http://www.downtown.co.uk/
Adult contemporary music for Tendring. Includes presenter profiles, playlist and contact information. Available on FM.
http://www.dream100.com/
Eagle Extra
Community radio station for Surrey and Hampshire. Includes schedule, station and tuning information.
http://www.eagleextra.co.uk/
Fire 107.6 FM
Dance and rhythmic contemporary hits for Bournemouth and Poole. Programme, music and presenter information, local news and sports, song request form and listen online.
http://fireradio.co.uk/
Forth 2
Classic hits and adult contemporary music for Edinburgh. Shows and presenter details, listen live, local news, sport and events information, online competitions and webcam.
http://www.forth2.com/
Forth One
Hits based FM station for Edinburgh and East Central Scotland.
GTFM
Non profit community service for Pontypridd. Gallery, schedule, presenter information, news and chatroom. Available on FM and live web stream.
http://www.gtfm.co.uk/
Galaxy 102.2
Dance and rhythm and blues for Birmingham. Includes local news and information, DJ and programme updates, plus music store. Available on FM, DAB and live web stream.
http://www.galaxybirmingham.co.uk/
Galaxy North East
Dance and rhythm and blues regional station. Includes local news and information, DJ and programme updates, plus music store. Available on FM, DAB and live web stream.
http://www.galaxynortheast.co.uk/
Galaxy South Coast
Dance music station for South Hampshire. Station news and information, including music, presenters and shows, plus local news, sports, entertainment and events. Available on FM, DAB and live web stream.
http://www.galaxysouthcoast.co.uk/
Glide 107.9
Dance and rhythm and blues music for Oxford. Presenter and music information, schedule and features. Available on FM and live web stream.
http://www.glidefm.co.uk/
Classic gold format local radio network, covering most areas of the South East, South West, Eastern England and the Midlands. Presenters, schedule, station and events information. Available on AM, DAB and live web stream.
http://www.mygoldmusic.co.uk/
Hallam FM
Chart and adult contemporary music for Sheffield and South Yorkshire. Includes schedules, DJ profiles, events, galleries, and competitions. Available on FM, DAB and live web stream.
http://www.hallamfm.co.uk/
Heart 100-102 South Devon
Adult contemporary music for Kingsbridge and surrounding area. Features schedules, presenter profiles, showbiz and music news. Available on FM and live web stream.
http://www.heart.co.uk/southhams/
Heart 100.7 West Midlands
Melodic adult contemporary music for the West Midlands. DJ and programme information, competitions, what's on guide, music information and shop. Available on FM, DAB and live web stream.
http://www.heartwestmids.co.uk/
Heart 102.4 Gloucestershire
Contemporary hit radio for Gloucester and Cheltenham. Features schedules, presenter profiles, showbiz and music news. Available on FM and live web stream.
http://www.heartgloucestershire.co.uk/
Heart 102.4 Norwich
Adult contemporary music for Norfolk and north Suffolk. Features schedules, presenter profiles, showbiz and music news. Available on FM, DAB and live web stream.
http://www.heartnorwich.co.uk/
Heart 102.6 Somerset
Contemporary hit radio for Taunton and Yeovil. Features schedules, presenter profiles, showbiz and music news. Available on FM, DAB and live web stream.
http://www.heartsomerset.co.uk/
Heart 102.6/97.4 Oxfordshire
Chart and contemporary hits for Oxford and Banbury. Station news and information, including music, presenters and shows, plus local news, sports, entertainment and events. Available on FM, DAB and live web stream.
http://www.heart.co.uk/oxfordshire/
Heart 102.7 Peterborough
Adult contemporary music for Peterborough. Features schedules, presenter profiles, showbiz and music news. Available on FM, DAB and live web stream.
http://www.heartpeterborough.co.uk/
Heart 102.9/97.0 Berkshire and North Hampshire
Adult contemporary music. Features schedules, presenter profiles, showbiz and music news. Available on FM, DAB and live web stream.
http://www.heartberkshire.co.uk/
Heart 103 Bath
Adult contemporary music for Bath. Features schedules, presenter profiles, showbiz and music news. Available on FM, DAB and live web stream.
http://www.heartbath.co.uk/
Heart 103 Cambridge
Adult contemporary music for Cambridge. Features schedules, presenter profiles, showbiz and music news. Available on FM, DAB and live web stream.
http://www.heartcambridge.co.uk/
Heart 103.3 Milton Keynes
Adult contemporary music for Milton Keynes. Features schedules, presenter profiles, showbiz and music news. Available on FM, DAB and live web stream.
http://www.heartmk.co.uk/
Heart 106.2 London
Adult contemporary music for London. DJ and programme information, competitions, what's on guide, music information and shop. Available on FM, DAB and live web stream.
http://www.heart.co.uk/london/
Heart 96.1 Colchester
Contemporary hit radio for Colchester. Features schedules, presenter profiles, showbiz and music news. Available on FM, DAB and live web stream.
http://www.heart.co.uk/colchester/
Heart 96.2/97.3 North Devon
Adult contemporary music for Barnstaple and surrounding area. Features schedules, presenter profiles, showbiz and music news. Available on FM and live web stream.
http://www.heartnorthdevon.co.uk/
Heart 96.3 Bristol
Adult contemporary music for Bristol. Features schedules, presenter profiles, showbiz and music news. Available on FM, DAB and live web stream.
http://www.heartbristol.co.uk/
Heart 96.4 Torbay
Adult contemporary music for Torquay and South Devon. Features schedules, presenter profiles, showbiz and music news. Available on FM and live web stream.
http://www.hearttorbay.co.uk/
Heart 96.6 Northampton
Contemporary hit radio for Northamptonshire. Features schedules, presenter profiles, showbiz and music news. Available on FM and live web stream.
http://www.heart.co.uk/northants/
Heart 97.0/103.0 Exeter
Adult contemporary music for Exeter and East Devon. Features schedules, presenter profiles, showbiz and music news. Available on FM, DAB and web stream.
http://www.heartexeter.co.uk/
Heart 97.0/96.6 Plymouth
Contemporary hit radio for Plymouth. Features schedules, presenter profiles, showbiz and music news. Available on FM, DAB and live web stream.
http://www.heartplymouth.co.uk/
Heart 97.1/96.4 Ipswich
Adult contemporary music for Suffolk. Features schedules, presenter profiles, showbiz and music news. Available on FM, DAB and live web stream.
http://www.heartipswich.co.uk/
Heart 97.2/102.2 Wiltshire
Adult contemporary music for Swindon and Wiltshire. Features schedules, presenter profiles, showbiz and music news. Available on FM, DAB and live web stream.
http://www.heartwilts.co.uk/
Heart 97.6 Dunstable
Adult contemporary music for Beds, Bucks and Herts. Features schedules, presenter profiles, showbiz and music news. Available on FM, DAB and live web stream.
http://www.heartdunstable.co.uk/
Heart Hampshire 96.7 and 97.5
Adult contemporary music station for South Hampshire. Station news and information, including music, presenters and shows, plus local news, sports, entertainment and events. Available on FM, DAB and live web stream.
http://www.hearthampshire.co.uk/
Heart Kent 103.1
Adult contemporary music for Maidstone, Medway and East Kent. Station news and information, including music, presenters and shows, plus local news, sports, entertainment and events. Available on FM, DAB and live web stream.
http://www.heart.co.uk/kent/
Heart Radio 102.3
Adult contemporary music for Dorset and West Hampshire. Features schedules, presenter profiles, showbiz and music news. Available on FM, DAB and live web stream.
http://www.heart.co.uk/dorset/
Heart Radio Essex 96.3
Adult contemporary music for Essex. Includes schedules, presenter profiles, competitions and local information. Available on FM, DAB and live web stream.
http://www.heart.co.uk/essex/
Heart Sussex 102.4 & 103.5
Chart and contemporary hits for Brighton, Eastbourne and Hastings. Station news and information, including music, presenters and shows, plus local news, sports, entertainment and events. Available on FM, DAB and live web stream.
http://www.heart.co.uk/sussex/
Isle of Wight Radio
Classic hits and news for the Isle of Wight. Includes on-air and station details, history and technical data, audio archive and local news and information. Available on FM and live web stream.
http://www.iwradio.co.uk/
Isles FM
Community station providing news and information for the Western Isles of Scotland. Station news and history, programme and presenter details plus advertising information. Available on FM.
http://www.isles.fm/
Jazz, soul, blues and rhythm and blues for the North West and London. Station and music information, music store and reviews. Available on FM, DAB and live web stream.
http://www.jazzfm.com/
Juice 107.2 FM
Local radio station for Brighton and Hove. Profile, schedule and events guide.
http://www.juicebrighton.com/
KCC Live 99.8FM
Advert free community radio for Knowsley also broadcasting on the internet. Profile, schedule, playlist and podcasts.
http://www.kcclive.com/
KLFM 96.7
Classic and contemporary hits for King's Lynn and West Norfolk. Includes presenters and schedules information, plus track request form. Available on FM.
http://www.klfm967.co.uk/
Keith Community Radio
Community service with music and dialogue for Keith, North East Scotland. News, events and competitions, schedule, presenter list and station history. Available on FM.
http://www.keithcommunityradio.com/
Kestrel FM
Adult contemporary music for Basingstoke and North Hampshire. Includes presenter and show information, local events and photo galleries. Available on FM and web stream.
http://www.kestrelfm.com/
Key 103
Chart and dance music for Manchester. Includes schedules, DJ profiles, events, playlist, information for advertisers, galleries, and competitions. Available on FM, DAB and live web stream.
http://www.key103.co.uk/
Chart and classic hits for Fife. Presenters, scheduling, competitions, local community news and information. Available on FM.
http://www.kingdomfm.co.uk/
LBC 97.3 FM and LBC News 1152 AM
Rolling news, talk and information stations for London. Includes schedule, news, weather, presenters and gallery. Available on FM, AM, DAB and live web stream.
http://www.lbc.co.uk/
Lincs FM
Adult contemporary music for Lincolnshire. Features podcasts, schedule, presenter profiles and gallery. Available on FM, DAB and live web stream.
http://www.lincsfm.co.uk/
London Greek Radio
Music and talk for the Greek community in North London. Programmes, advertising, history and events information. Available on FM and live web stream.
http://www.lgr.co.uk/
Magic AM
Gold and soft adult contemporary music for Sheffield and South Yorkshire. Presenters, gallery and competitions information. Available on AM and DAB.
http://www.magicam.co.uk/
Metro FM
Chart and contemporary hits for Newcastle and Tyne and Wear. Includes schedules, DJ profiles, events, playlist, information for advertisers, galleries, and competitions. Available on FM, DAB and live web stream.
http://www.metroradio.co.uk/
Chart music station for York and Thirsk. Community information including entertainment listings, business directory and regional news, plus station listings and information. Available on FM.
http://www.minsterfm.com/
Moray Firth Radio
Contemporary and classic hits for Inverness and North East Scotland. Includes station news and information, charts and gig guide. Available on FM and AM.
http://www.mfr.co.uk/
Northsound 1
Chart and contemporary hits for Aberdeen and North East Scotland. Schedule, entertainments guide, presenter and music information. Available on FM, DAB and live web stream.
http://www.northsound1.com/
Hit music from the last 40 years for Aberdeen and North East Scotland. Shows and music information, plus events diary. Available on AM, DAB and live web stream.
Peak FM
Chart and classic hits for Chesterfield, Matlock and North Derbyshire. Community information including entertainment listings, business directory and regional news, plus station listings and information. Available on FM.
http://www.peakfm.net/
Pirate FM 102
Contemporary and classic hits for Cornwall. Includes presenters and schedules information, plus track request form. Available on FM.
http://www.piratefm.co.uk/
Premier Christian Radio
Christian news, talk, information and music. Includes forum, news and features. Available on AM, DAB, Freeview, Sky and live web stream.
http://www.premierradio.org.uk/
Pulse 1
Chart music station in Bradford and Huddersfield. News, sport, and electronic polling.
http://www.pulse1.co.uk/
Radio Aire
Hit music for Leeds. Includes programme schedule, background information on presenters and DJs, news, music, and events and gigs. Available on FM, DAB and live web stream.
http://www.radioaire.co.uk/
Radio Borders
Chart and classic hits for the Scottish Borders. Local news and information, presenter profiles, playlist and music request. Available on FM and live web stream.
http://www.radioborders.com/
Chart and contemporary hits for Liverpool. Includes schedules, DJ profiles, events, playlist, information for advertisers, galleries, and competitions. Available on FM, DAB and live web stream.
http://www.radiocity.co.uk/
Radio Plymouth 106.7FM
Includes presenter profiles, local news, photo galleries and competitions. Available on FM and live web stream.
http://www.radioplymouth.com/
Reading 107 FM
Adult contemporary music and sport, based at Reading FC. Includes local news, sport and presenter blogs. Available on FM and on-line.
http://www.jackfmberkshire.com/
Real Radio
Talk and adult contemporary music for South Wales regional, South and West Yorkshire, and Central Scotland regional. Local news, competitions, DJ interviews and station information. Available on FM, DAB and live web stream.
http://www.realradio.co.uk/
Real Radio Northwest
Music and speech station. Includes guide to programmes and presenters, with news, events and competitions. Available on FM, DAB and online.
http://www.realradionorthwest.co.uk/
Red Dragon FM
Chart and contemporary hits for Cardiff and Newport. Station news and information, including music, presenters and shows, plus local news, sports, entertainment and events. Available on FM, DAB and live web stream.
http://www.reddragonfm.co.uk/
Arts radio project broadcasting to the South Bank and Bankside in London. Includes listings, project and station information. Available on FM and live web stream.
http://www.resonancefm.com/
Ridings FM
Adult contemporary music for Wakefield. Includes podcasts, photo galleries, sports and local news. Available on FM, DAB and live web stream.
http://www.ridingsfm.co.uk/
Contemporary hits for Lancashire. Includes schedules, DJ profiles, events, playlist, information for advertisers, galleries, and competitions. Available on FM, DAB and live web stream.
http://www.rockfm.co.uk/
Silk 106.9 FM
Soft adult contemporary music for Macclesfield and North East Cheshire. Community information including entertainment listings, business directory and regional news, plus station listings and information. Available on FM.
http://www.silkfm.com/
Smooth Radio
Offers online listening, broadcast from the Northwest. Includes information on people, schedule, competitions, events, business, records, dating and tickets.
http://www.smoothradio.co.uk/
Southend Radio 105.1
Features on presenters and shows, plus schedule, gallery and local news. Available on FM and online.
http://www.southendandchelmsfordradio.com/
Spectrum Radio 558AM
International community news and information for London. Programme information for each ethnic service, schedule listing and contact details. Available on AM and DAB.
http://www.spectrumradio.net/
Spire FM 102
Classic hits for Salisbury. Programme, presenters, travel and entertainment information, plus competitions and news. Available on FM.
http://www.spirefm.co.uk/
Spirit FM
Classic and contemporary hits for Chichester, Bognor Regis and Littlehampton. Includes programming information, presenter profiles, news and competitions. Available on FM.
http://www.spiritfm.net/
Splash FM
Adult contemporary/gold station for Worthing, West Sussex. Includes news, weather and community information. Available on FM and web stream.
http://splashfm.com/
Star 107.5 FM
Adult contemporary and classic hits for Cheltenham and North Gloucestershire. Community information including entertainment listings, business directory and regional news, plus station listings and information.
http://www.totalstar.co.uk/
Sunrise Radio
Asian community station in Hounslow, Bradford, Glasgow, Edinburgh, Coventry and Wolverhampton. Details on programme schedule, presenters and music. Available on FM, AM, DAB and live web stream.
http://www.sunriseradio.com/
Swansea Sound
Classic hits for Swansea. DJ profiles, schedules, station information and galleries. Available on AM and DAB.
http://www.swanseasound.co.uk/
Contemporary hits for Teesside. Features, competitions, DJs, galleries, schedules and events. Available on FM, DAB and live web stream.
http://www.tfmradio.com/
Tay AM
Classic hits for Dundee and Perth. Schedule, shows and presenter information, what's on guide. Available on AM, DAB and live web stream.
http://www.tayam.co.uk/
Tay FM
Chart hits and adult orientated rock station for Perth and Dundee. Presenters, shows, news, sport and entertainment information, plus chatroom facility. Available on FM, DAB and live web stream.
http://www.tayfm.co.uk/
Ten-17 FM
Contemporary hit radio for Harlow. Features schedules, presenter profiles, showbiz and music news. Available on FM and live web stream.
http://www.ten17.co.uk/
The Arrow
Adult orientated classic rock digital radio station covering the Midlands, South Wales and the West of England. News and station information. Available on DAB and live web stream.
http://www.thearrow.co.uk/
Chart and contemporary hits for Swansea. Presenter, station and schedule information, competitions and features. Available on FM, DAB and online.
http://www.thewave.co.uk/
Touch 102FM
Adult contemporary music for Warwickshire. Includes presenter profiles, playlist, games and photo gallery. Available on FM and web stream.
http://www.102touchfm.co.uk/
Tower FM
Contemporary and classic hits for Bolton and Bury. Community information including entertainment listings, business directory and regional news, plus station listings and information. Available on FM.
http://www.towerfm.co.uk/
Trent FM
Adult contemporary music for Nottinghamshire. Features schedules, presenter profiles, showbiz and music news. Available on FM, DAB and live web stream.
http://www.trentfm.co.uk/
Viking FM
Chart hits for Hull and East Yorkshire. Competitions, features, DJs, galleries, schedules and events. Available on FM, DAB and live web stream.
http://www.vikingfm.co.uk/
Soft rock and adult contemporary regional station for the Solent. Includes shows and presenter information, news, entertainments and gig guide. Available on FM and live web stream.
http://www.wave105.com/
Wessex FM
Adult contemporary and classic hits for West Dorset. Community information including entertainment listings, regional news, station listings and information. Available on FM.
http://www.wessexfm.com/
West Sound
Easy listening for Ayrshire. Includes schedules, presenter details, news headlines and what's on guide. Available on AM, DAB and live web stream.
http://www.westsound.co.uk/
WestSound FM
Classic hits for Dumfries and Galloway. Includes schedules, presenter profiles, competitions, message board and photo gallery. Available on FM.
http://www.westsoundradio.com/
Wythenshawe FM 97.2
A non-profit community service for Wythenshawe, providing music, interviews and features of local interest. Contains schedule, presenters and programme information. Available on FM.
http://www.wfmradio.org/
XFM 104.9
Alternative and new rock for London. Includes news, shop, reviews, gig guide, message board and on-air information. Available on FM, DAB and live web stream.
http://www.xfm.co.uk/
Yorkshire Coast Radio
Contemporary and classic hits for Scarborough, Whitby and Bridlington. Presenter profiles, local news, plus show and events information. Available on FM.
http://www.yorkshirecoastradio.com/
kmfm
Group of stations broadcasting classic and contemporary hits for Kent. Includes group information, schedule, station and presenter details. Available on FM.
http://www.kmfm.co.uk/
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text:
Er is sprake van een Osborne-effect als mededelingen van een bedrijf omtrent toekomstige producten ertoe leiden dat consumenten hun aankopen van het huidige productaanbod uitstellen. De oorsprong van deze uitdrukking komt van de vermeende marketingmisser die door Osborne Computer Corporation in de jaren 80 gemaakt werd toen het de opvolger van de Osborne 1 aankondigde. Dit leidde tot een scherpe daling in verkopen, met als gevolg een inkomstenstrop die het bedrijf niet meer te boven kwam.

De Osborne-mythe
In 1983 deed de uitvinder Adam Osborne de vooraankondiging van een nieuwe generatie toekomstige computermodellen (genaamd de "Executive" en "Vixen"). In deze vooraankondiging werd vooral de nadruk gelegd op het feit dat ze in elk opzicht beter zouden presteren dan het huidige model. Volgens de mythe zouden de verkopen na deze aankondiging direct vrijwel volledig in elkaar gezakt zijn omdat klanten verkozen te wachten op deze twee nieuwe verbeterde systemen; hierdoor stortte de cashflow in en ging het bedrijf enkele maanden later failliet.

Vooraankondigingen van producten die tot het Osborne-effect leiden zijn een voorbeeld van een zelfontkrachtende voorspelling (het tegenovergestelde van een zelfbevestigende voorspelling), omdat de vooraankondiging van het nieuwe product uiteindelijk verantwoordelijk is voor het vroegtijdig mislukken van de productintroductie.

Na nieuwe aandacht voor het effect in 2005 (zie volgende paragraaf), interviewde de columnist Robert Cringely de voormalig Osborne-werknemer Mike McCarthy en verhelderde enkele aspecten achter het "Osborne-effect". Blijkbaar had het nieuwe Executive model een prijskaartje van $2.195 en was het met een 17,9 cm (7") scherm uitgerust, terwijl Kaypro, een concurrerende speler, een computer met een 22,9 cm (9") scherm op de markt bracht voor $400 minder. Ook voor de vooraankondiging bleek de Kaypro-computer al tot lagere verkoopcijfers van de Osborne 1 te leiden, (een computer met een 12,7 cm (5") scherm voor $1.995, ofwel 200 dollar duurder dan de Kaypro). De voorraad bestaande Osborne 1 werd opgeruimd en consumenten stapten massaal over op de Kaypro.

Op 17 juni 2005 schreef Daniel Eran van Roughly Drafted dat in 1983 Osborne Computer "meer problemen had dan alleen een vooraankondiging van een toekomstig product". Eran merkte verder op dat Osborne Computer "een kleine, drie jaar oude onderneming was met een vluchtige klantentrouw, en hoog verloop onder zijn ontwikkelaars, gecombineerd met een sterke concurrentie en tegelijkertijd worstelend met kwaliteitsproblemen van hun huidige product". Concurrenten van het bedrijf waren onder andere het superieure product van Kaypro; de Apple II, die naast zijn eigen software ook de software aankon van Digital Researchs CP/M-systeem dat ook door Osborne gebruikt werd; IBM's opkomende standaard PC; en Compaqs Osborne-achtige draagbare PC-compatible.

Het artikel op Rougly Drafted gaf verder het voorbeeld van Apple waarbij het "vaak aangehaalde Osborne-effect" geen significante invloed op het besluit van Apple had om op een Intel-platform over te stappen, omdat de omstandigheden van Apple zo verschillend waren met die van Osborne. De afwezigheid van het Osborne-effect bij Apple werd verder geïllustreerd aan de hand van de verkoopcijfers van Apple-computers die herhaaldelijk geen discontinuïteit lieten zien, hoewel er wel aankondigingen plaatsvonden die de huidige productportfolio achterhaald maakten: de Apple IIGS, die nog zeven jaar verkocht werd nadat de introductie van de Apple Macintosh haar achterhaalde; de Quadra 630 en vergelijkbare op de 040-architectuur gebaseerde Macs die nog lang verkocht werden nadat de PowerPC-architectuur aangekondigd werd, het feit dat de vraag naar PowerMac G4's nog lang in stand bleef ondanks de introductie van de PowerMac G5 en - volgens het artikel - zelfs Apple ertoe bewoog om de oudere G4 weer te herintroduceren (in werkelijkheid was Apple nooit opgehouden G4's te verkopen), en ten slotte de vraag naar Mac OS 9 die ook na de introductie van Mac OS X aanwezig bleef.

Op 20 juni 2005 citeerde The Register Osbornes eigen memoires en interviewde ze voormalig Osborne-reparatiemedewerker Charles Eicher omtrent de slechte bedrijfsvoering die de werkelijke oorzaak van Osborne Computers ondergang zou zijn geweest Blijkbaar waren de verkopen, hoewel deze inzakten na de eerste vooraankondiging, later weer in een stijgende lijn terechtgekomen, waardoor er opnieuw financiële middelen het bedrijf in kwamen. Rond die tijd ontdekte een van de hogere managers van het bedrijf een aantal complete moederborden van de oudere Osborne modellen (ter waarde van $150.000), zonder dat de andere onderdelen om er complete computers van te maken aanwezig waren. Enige tijd en een paar verkeerde beslissingen later, was er $2 miljoen - veel meer dan iedereen vooraf gedacht had - uitgegeven aan beeldbuizen, geheugen, diskettestations en systeemkasten. Pas op dat moment bezweek de onderneming aan haar ontstane schulden.

Het lijkt daarom dat hoewel er met name in de computerindustrie veel gerefereerd werd aan de vooraankondigingsmythe, dat hiervan in het geval van Osborne geen sprake van is. In die zin kan zelfs in zekere zin van een broodjeaapverhaal gesproken worden.

Voorkomen
De meeste technologiebedrijven bewaken tegenwoordig de hoeveelheid informatie omtrent nieuwe producten en de aard van deze informatie. In het algemeen kan gesteld worden dat hoe sterker de marktpositie van een onderneming is, hoe minder informatie omtrent nieuwe plannen en prijzen naar buiten komt.

Andere voorbeelden
 In 1978 kondigde North Star Computers een nieuwe versie van hun floppydiskcontroller aan die een verdubbeling van de opslagcapaciteit betekende, maar desondanks voor dezelfde prijs als het huidige product verkocht zou worden. Verkopen stortten in en het bedrijf ging bijna failliet.

Marketing en verkoop

redpajama_set_name: RedPajamaWikipedia


"Ronnie had a unique and wonderful voice.
He will be sadly missed in the rock and roll world.
「There will be a Public Memorial Service for Ronnie James Dio on Sunday, May 30th at 2:00 PM at The Hall Of Liberty located at Forest Lawn Hollywood Hills, 6300 Forest Lawn Drive, Los Angeles, CA 90068.
This will be a celebration of the life and music of Ronnie James Dio and is open to all of his friends and fans from around the world.


text:
The Christie developing new tool to monitor radiotherapy side effects
Press Release Posted 06 January 2015
Researchers at The Christie NHS Foundation Trust have investigated a patient-centred approach to assessing the side effects of radiotherapy.
The research has shown that it may be able to improve the detection and management of treatment-related toxicity.
For lung cancer that cannot be removed with surgery, radiotherapy is the primary treatment option. However, it is associated with a range of side effects, including fatigue and inflammation of the oesophagus and lungs.
Current methods to record treatment-related toxicities rely on assessment by health care professionals. Now a team from The University of Manchester and The Christie - both part of the Manchester Cancer Research Centre - has explored the use of patient-reported outcomes to improve the recording of side effects for lung cancer patients.
Dr Corinne Faivre-Finn, a consultant based at The Christie NHS Foundation Trust and a researcher in The University of Manchester's Institute of Cancer Sciences, who led the research, said: "Such patient-reported outcome tools have been mainly evaluated for use with chemotherapy treatments. We wanted to assess their feasibility and relevance in lung cancer patients undergoing radiotherapy."
The group looked at the agreement between side effects as reported by doctors and the patients themselves. They also evaluated the relationship between reported toxicities and quality-of-life measures, relating to aspects such as tiredness, anxiety and shortness of breath.
Patients were asked to fill in questionnaires covering both side effects and quality of life at three time points: before treatment, at the end of radiotherapy and at later follow up. The consultants answered questions at identical time points covering the same common radiotherapy-related toxicities for each patient.
The study found that there was strongest agreement between the patient's scoring of side effects and measures relating to their quality of life. Toxicities as recorded by the clinicians appeared to underestimate their severity.
"This was the first study in Europe to explore such a patient-centred approach to recording side effects. Incorporating this method into cancer care could allow us to detect and manage serious effects earlier. It could also improve patient-doctor relationships and help doctors better understand the full impact of treatment on patients," added Dr Faivre-Finn.

redpajama_set_name: RedPajamaCommonCrawl


text:
Rwanda's Louise Mushikiwabo denies rights-abuse claims
Rwanda's foreign minister has denied a wide range of allegations against her country, including human-rights abuses, suppression of press freedoms, and extrajudicial killings.
Taking to Al Jazeera's Mehdi Hasan on the show Upfront, Louise Mushikiwabo dismissed the claims brought forth by Amnesty International, Human Rights Watch and Reporters Without Borders, and countries Rwanda is allied with on the government's intolerance for opposition voices and criticism.
"Let me put it this way: Rwanda, as any other country that I know of, has its own way of doing things," Mushikiwabo said in response to a remark that Rwanda seems to be on its own in defending itself.
READ MORE: Timeline – How Rwanda's genocide unfolded
"And not everybody should be agreeing with what the government of Rwanda is doing."
Mushikiwabo also revisited her government's stance that the BBC was banned from Rwanda because it promoted "genocide ideology".
"The BBC produced a documentary film which is a total denial of the history of Rwanda, particularly the history of the genocide," she said.
"In Rwanda that is not acceptable."
Officer's murder
Mushikiwabo also commented on the alleged murder in 2014 of the exiled Rwandan intelligence officer Patrick Karegeya, who was found dead in his hotel room in Johannesburg.
The country's defence minister, in response to the incident, had said: "When you choose to be a dog, you die like a dog" suggesting the government's complicity in Karegeya's death.
"Let me again put it this way: I don't know anybody who betrays a country that gets rewarded," Mushikiwabo said on the issue.
She said Karegeya, who was allegedly killed while in exile despite never having been convicted of a crime, threatened Rwanda.
"Why should I be unhappy about my enemies and people who threaten?" she asked.
When it came to Rwanda's involvement in the violent political crisis in neighbouring Burundi, Mushikiwabo insisted her country's only association was in taking care of Burundian refugees.
She said on the crisis: "When people make wrong choices then they have to live with the consequences."
Mushikiwabo rejected an UN Panel of Experts' report from earlier this year that accuses Rwanda of recruiting and training Burundian refugees in Rwanda with the goal of overthrowing Burundian President Pierre Nkurunziza.
"If I wanted to overthrow I would use my own army. I would not pick up children in a refugee camp," she said.
The crackdown on Burundians follows the expulsion of thousands of Rwandans by Burundi since April 2015.
WATCH: Rwanda: From hatred to reconciliation
Burundi has been in political crisis since then, after Nkurunziza controversially decided to run for a third term which he went on to win in a July election.
Hundreds have been killed and more than 200,000 have fled Burundi, according to the UN, raising fears of a return to the civil war fought between 1993 and 2006.
Burundi has accused Rwanda of interfering in its political crisis, which has seen Burundian government forces clash with protesters and rebels who say the president violated the constitution by standing for another term.
Rwanda has denied Burundi's accusations.
The full interview will be aired at 19:30 GMT on Friday and will also be available online at www.aljazeera.com/upfront.
The post Rwanda's Louise Mushikiwabo denies rights-abuse claims appeared first on African Media Agency.
Source:: http://amediaagency.com/rwandas-louise-mushikiwabo-denies-rights-abuse-claims/
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Cape Town – The DA criticised Finance Minister Malusi Gigaba's Budget Speech on Wednesday for "hammering the poor" and increasing taxes.
The DA's deputy shadow minister of finance, Alf Lees, said the increase in taxes as announced by Gigaba was "symptomatic of an ANC government which has failed to plan ahead and make the necessary cost-cutting measures to shield ordinary citizens from poverty".
"The announcements made today (Wednesday) are nothing less than a massive body blow to poor South Africans. They will dampen economic growth and fail to create much-needed jobs," said Lees.
He said the VAT increase of one percentage point was "a smack in the face for millions of South Africans who face a daily battle to put food on the table".
"Instead of taking decisive action to cut wasteful expenditure and trim the fat, the Minister has introduced proposals for cost-cutting that will only reduce service delivery," he said.
Lees identified the reduction of provincial budgets, the reduction of provincial conditional grants, specifically with Human Settlements and Education infrastructure, and the reduction of local government grants as issues.
"The choice to cut funding for building schools and employing police officers will only put the futures and safety of our people at risk and is a terrible trade-off," he said.
"Instead of stabilising the national debt levels, they will continue to rise to R 3.3 trillion over the next three years and debt service costs will amount to R 592bn over the medium term," Lees said.
Gigaba has failed "to cut the fat" and has instead opted to protect a handful of individuals by reaching "into the pockets of poor South Africans to cover the cost".


SOFT WINDY DAY- is part of my "LIGHT and FLOWERS" series I started.
Giving life to colors on a huge wall using soft calming neutral tones .
The shipping cost is for the continental US . For other destinations please contact me before you place your order for the shipping options.Please, contact me before you place the order so I can adjust the shipping cost for you!
-international : USPS Priority Mail w/tracking- will ship without the wood frame due to the size of the canvas and shipping restrictions to certain countries.


text:
Blog post Part of series: Covid-19, education and educational research
Postgraduate research students' experiences of the coronavirus pandemic
Ross Goldstone, Cardiff University Jingwen Zhang, University of Manchester Victoria Christodoulides, University of Bath 23 Aug 2021
How to contribute Subscribe to RSS
The ongoing coronavirus pandemic has caused most postgraduate research (PGR) students to encounter research restrictions and undertake their research duties from home (see Burridge et al., 2020). Yet an insufficient amount of research has explored PGR students' pandemic experiences. This blog post draws on an online survey of 994 UK-based PGR students conducted in January 2021, which explored the experiences of students, the support received during lockdown and the future plans of PGRs after the coronavirus pandemic (further methodological information is available here).
In our survey, we asked students whether they were experiencing a number of mental health and social issues as a result of the pandemic. Eighty-five per cent of the respondents reported that they experienced anxiety and stress; 80 per cent experienced fatigue and burnout; 66 per cent felt isolated or lonely; and 69 per cent reported other mental health concerns. Our findings align with previous research on PGR students' mental health, which has shown that 80 per cent of PGR students and early researchers experienced some level of mental distress (Byrom, 2020).
We also measured average working hours before and after the pandemic began, discovering that a pre-pandemic average of 37.6 working hours – which is consistent with research funding bodies' requirements, such as the Economic and Research Council – fell to 32.4 hours during the pandemic and are evidently more disperse (see figure 1). This suggests a varied negative impact of the pandemic on PGR students' working time.
Figures 1a & 1b: Students' average working week (hours) before and after the onset of the Covid-19 pandemic
Data shows that the reduction in weekly working hours was most pronounced among students with caring responsibilities (9.6 hours), third-year students (6.8 hours) and natural science students (6.1 hours). In addition, some students reported working 48 or more hours per week, with international students (18 per cent) and fourth-year students (19 per cent) more likely to report this.
Furthermore, over half of participating students (52 per cent) reported having adapted to working from home somewhat or very ineffectively, which likely placed additional pressure on students' productive working time during the pandemic. Ineffective working environments and practices, moreover, would have been shaped by the inaccessibility of homeworking equipment, an issue reported by 41 per cent of respondents (see figure 2). Other forms of support, including training on adjusting research plans and adapting methods were also unavailable for a significant proportion of the sample (52 and 44 per cent respectively). This shows variable access to important support for completing a research degree during a pandemic and raises questions regarding support received by PGRs.
Figure 2: Forms of support available to participating PGR students (%)
Among students who had received training on adjusting research plans (for instance online research), this was 'unhelpful' or 'very unhelpful' for most students (69 per cent) (see figure 3). This means that, even where participating students had access to training, this was felt to be inadequate. This is concerning given that 59 per cent of the sample had been required to adjust their research in light of the pandemic, with this adaptation taking up to six months for 57 per cent, more than six months for 9 per cent, and still ongoing for 35 per cent of participating students.
Supervisory support to adjust research plans (such as changing to remote research) and library resources (such as access to online books) were reported as particularly helpful, with 81 per cent and 67 per cent of students feeling each had been either 'helpful' or 'very helpful', respectively (see figure 3). This shows that support aimed to facilitate effective home working (such as online study resources) or delivered by supervisors was positively received by participating students.
Figure 3: Perceived helpfulness of selected forms of support for participating students
Higher levels of satisfaction (either satisfied or extremely satisfied) were expressed towards institutional support (37 per cent) compared to research council (11 per cent) and United Kingdom Research and Innovation (UKRI) (5 per cent) support. In light of students' pandemic experiences and insufficient support received, 58 per cent were either 'very unconfident' or 'not so confident' in completing their studies on time. Moreover, one-in-four (26 per cent) were now considering leaving their studies.
Despite the difficulties experienced by PGR students during the coronavirus pandemic, many reported being able to achieve a number of 'outputs'. Completing or drafting a thesis chapter, teaching experience and delivering a conference presentation were common outputs achieved by participating students (see figure 4). However, there were differences across years of study, particularly in completion of a thesis chapter. Many of the participating students did not complete a thesis chapter, despite this typically forming a core part of annual progress reviews during doctoral degrees.
Figure 4: Participating students' achievements during the pandemic by year of study (%)
These findings evidence the difficulties experienced by participating UK PGR students during the coronavirus pandemic, demonstrating negative experiences across health and wellbeing, academic study and students' personal lives. Not only does our survey suggest that provision of support is variable for participating students, but it also shows that the utility of support provided is questionable. As a result, further research is required to explore how best to support PGR students during the ongoing pandemic, which should work collaboratively with students in co-constructing effective support measures.
Burridge, H., Gates, S., Iyer, P., Roberts, E., & Griggs, J. (2020). UKRI Covid-19 student consultation: Final report. NatCen Social Research. https://www.ukri.org/wp-content/uploads/2020/11/UKRI-11112020-NatCenUKRICOVID-19StudentConsultation.pdf
Byrom, N. (2020). COVID-19 and the research community: The challenges of lockdown for early-career researchers. Institute of Psychiatry, Psychology and Neurosciences, King's College London. https://elifesciences.org/articles/59634
Early Career Researcher Network Higher Education Mental Health, Wellbeing and Education
Ross Goldstone
Ross Goldstone is a PhD candidate at the School of Social Sciences, Cardiff University, where he is studying the relationship between social class and further education participation and experience. His current interests are in educational inequality and the sociology of education, in addition to wider debates around social class, and the ideas of Bourdieu and their application in educational research. Further information is available on his
Jingwen Zhang
Jingwen Zhang is a PhD candidate at the School of Social Sciences, University of Manchester. Her PhD focuses on active ageing and rural–urban health inequality in China. She is interested in life course theory, social determinants of health and longitudinal data analysis. Further information is available on her
Victoria Christodoulides
Victoria Christodoulides is an SWDTP scholarship PhD student within the Health Department at the University of Bath. Victoria's project focuses on co-exploring how childhood trauma recovery literacies impact understanding and practising of recovery beyond the biomedical. Using co-constructive participatory action arts-based approaches, Victoria looks to explore how informal public pedagogical spaces can support this extension. Victoria is utilising an interdisciplinary perspective incorporating sociology, policy and the arts with expertise from the University of Bath and the University of the West of England. Working collaboratively with external organisations, the project will develop an engaging experience through an exhibition examining these questions within public space. Victoria engages with post-qualitative inquiry and feminist new materialist thought to support the re-imagination of how recovery literacies are conceptualised and utilised, with particular attention to...
Covid-19, education and educational research series
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The impact of Covid-19 and the UK public lockdown on postgraduate research students in the UK
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text:
Baureihe E 91 - seria niemieckich lokomotyw elektrycznych i wyprodukowanych w latach 1925-1929 dla Deutsche Reichsbahn specjalnie do obsługi pociągów towarowych na trudnych trasach górskich.

Charakterystyka
Nadwozie lokomotywy z dwiema kabinami maszynisty na krańcach, składało się z trzech części połączonych ze sobą miechami. Pojazd wyposażono w dwa połączone ze sobą odbieraki prądu typu pantografowego, które umieszczono na skrajnych częściach pudła. Lokomotywa posiadała dwa trzyosiowe wózki silnikowe, pomiędzy którymi umieszczono transformator trakcyjny. Napęd z dwóch podwójnych silników na osie odbywał się za pomocą koła zębatego oraz połączonych z nim wiązarów. Silniki posiadały wentylację obcą. Wyłącznik szybki wyposażony został w komorę olejową. Sterowanie pracą lokomotywy odbywało się za pomocą styczników elektromagnetycznych oraz nastawnika o 19 pozycjach. Producentem zarówno konstrukcji mechanicznej, jak i części elektrycznej lokomotyw, które trafiły na Śląską Kolej Górską, była firma AEG. Lokomotywy te mogły prowadzić na pochyleniu 10‰ pociągi towarowe o masie 1200 ton z prędkością 35 km/h lub pociągi pasażerskie o masie 500 ton z prędkością 45 km/h.

W 1922 zamówiono 30 lokomotyw, z czego 14 (EG 581-594) trafiło do Jeleniej Góry, natomiast pozostałych 16 - do Bawarii. Ostatecznie zamówiono jeszcze 4 sztuki, które trafiły na południe Niemiec (1924) i 12 sztuk, przeznaczonych na tory Dolnego Śląska (1927).

Eksploatacja
Po zelektryfikowaniu linii kolejowych zlokalizowanych na śląskich oraz bawarskich pasmach górskich, wobec niskiej przydatności starych elektrowozów, kolej niemiecka potrzebowała lokomotyw elektrycznych do prowadzenia ciężkich pociągów towarowych. W październiku 1922 roku zamówiono szesnaście lokomotyw elektrycznych dla lokomotywowni w Monachium i czternaście elektrowozów dla lokomotywowni w Jeleniej Górze. W późniejszym czasie zamówiono cztery elektrowozy do prowadzenia ciężkich pociągów towarowych na bawarskich liniach kolejowych. Pierwszy elektrowóz prezentowano od 21 września do 5 października 1924 roku na Wystawie Techniki Kolejnictwa w Seddin. Elektrowozy w 1926 roku zostały oznakowane przez koleje niemieckie jako Baureihe E 91. W 1929 roku wyprodukowano dwanaście ostatnich lokomotyw zamówionych dla Śląska. W latach 1933-1945 9 lokomotyw znalazło się w południowych Niemczech (lokomotywownie Ulm i Kornwestheim od 1933, Landshut od 1944, Augsburg od 1945). Pozostałych 5 sztuk – zarówno tych, które koniec wojny zastał w Sudetach (E 91 83, 84 i 87), jak i w warsztatach naprawczych w Dessau (E 91 85 i 86) – padło łupem Armii Czerwonej i zostało wywiezionych do ZSRR. Po wojnie elektrowozy były eksploatowane zarówno przez koleje wschodnioniemieckie, jak i zachodnioniemieckie.

Przypisy

Lokomotywy elektryczne eksploatowane w Niemczech


My thanks go out to our U.K. friend, Lonesamurai. Thanks for showing me the site! I love the music, love the DJs, and love the Forum! Maybe one day I can try out to be a DJ?
well i guess even though hes not my frien thank you to Nelks for making the Patricks day party so much fun!
I would like to thank Grau for introducing me to SI back when I was one of his guildies in "GW" Academy Of Heroes.
I would like to thank DJ Darkfall and Rockstar for getting me addicted to SI. I listened to them way back when I was in Korea and it was awesome.
Last edited by Ego on Sun Jun 22, 2008 4:16 am, edited 1 time in total.
How did you find out about SI Radio?: DJ Verve let it slip one time.
I suppose I'm blaming... uh... thanking DJ Verve for introducing me, although I think it was a mutual friend who told me he was a DJ somewhere, and it was more like me convincing him to show me where.
Nice thread. Let me say "official" thanks for having me in there for a year, getting to know you crazy great bunch of people and all the fun and help during my stay.
Thanks to Chaotix for introducing me to the station through his show.


Photos by, clockwise from top left: Jennifer Walker, Sarein Basi-Primeau, Kelsey Collins, and Cody Gold. The photo at bottom left shows coonstripe shrimp apparently attacking a moon jelly (Aurelia labiata) on a piling.
The coonstripe shrimp is translucent orange-red to brownish-red. Its tail (abdomen) is marked by irregular reddish-brownish stripes with a diagonal orientation slanting down towards the tail; its body is marked by thin white lines, and small white and red spots. Small electric blue spots sometimes dot the tail and body. The end of the tail (telson) bears six pairs of spines forming two lines. This shrimp species reaches 15 cm long.
This species is often seen on pilings and docks; it also inhabits rocky and sandy ocean floors to a depth of approximately 200 m or more. Adults tend to stay in the subtidal, while juveniles may be found in shallower areas. Its range extends from northern Alaska to northern Mexico.
The irregular reddish-brown diagonal stripes on the tail are a key identifying feature of the coonstripe shrimp; the rough patch shrimp (Pandalus stenolepus) also has electric blue spots and spines on its telson (3-5 pairs), but lacks the same diagonal stripes and is less translucent. Another species, P. hypsinotus, is also commonly called coonstripe (or coonstriped) shrimp - which can lead to some confusion.
This species is harvested by recreation and commercial fisheries, and may appear in hauled-in crab traps.
Cowles, D. (2005). Pandalus danae Stimpson, 1857. Invertebrates of the Salish Sea. Rosario Beach Marine Laboratory. Accessed 29/09/2014.
Harbo, R. M. (2011). Whelks to whales: Coastal marine life of the Pacific Northwest. Madeira Park, BC: Harbour Publishing. P. 109.
Lamb, A., and Hanby, B. (2005). Marine Life of the Pacific Northwest [electronic resource]. Madeira Park, BC: Harbour Publishing.


text:
Buhler Community Foundation Match Day coming next week
BUHLER, Kan. — The Buhler Community Foundation will host its Match Day next Tuesday, Dec. 3.
Officials say this is always a great day to inspire and witness Buhler's community spirit while celebrating Giving Tuesday philanthropy.
Donations to Fund for Buhler will multiply on Match Day.
The community foundation will match up to $15,000 in gifts to the Fund for Buhler, the foundation's unrestricted grant-making fund. Money and assets given to the community foundation are invested and the earnings from the investments are returned to the community each year in the form of grants. Last year's Match Day drew 49 donors who gave more than $23,000.
Four funds will be accepting donations on Tuesday:
Fund for Buhler
Buhler Public Health Fund
Sunshine Meadows Retirement Community Endowment Fund
Buhler USD 313 Educational Endowment Fund
Donations must be made from 8:30 a.m. to 5:30 p.m. at the Mustard Seed, 214 N. Main St., or Sunny's Café, 400 S. Buhler Rd. Participants may enjoy a free treat when they give.
Checks must be made payable to Buhler Community Foundation. Donations to the Fund for Buhler will be matched dollar-for-dollar while matching funds last. A form will be available at both locations to indicate which endowment(s) will benefit.
Kan. foster care agency trains social workers to be 'personal 911' for kids
Kansas Department for Children and Families' social workers hold up sheets of papers illustrating the story of a 17-year-old boy who they expect in five years to be in prison or dead if they don't find him help. Evert Nelson / The Topeka Capital-Journal
By PEGGY LOWE
The foster kid is a 17-year-old boy who was kicked out of his home when he was 10, started using drugs by 13, and in five years is expected to be in prison or dead.
Kansas Department of Children and Families social workers check on him every day and there's been some progress: He's now in an independent living facility and he's not using drugs anymore. But he still has many needs, including a coming heart transplant.
How can he be helped?
About 100 social workers from the Kansas Department for Children and Families considered that question at a bootcamp-stype workshop in Topeka on Friday with Kevin Campbell, creator of a national model called Family Finding.
Campbell said the team assigned to the boy must find relatives or people who care about him and have them intervene in the boy's life.
"Basically you are building the personal 911 system for this kid," Campbell said. "We call it a firehouse intervention. Quite literally, he needs a personal fire department ready to help him respond to the life he lives, which is a crisis every day."
The goal of Family Finding is getting kids connected to someone who loves them in hopes of keeping them out of the foster care system and potentially preventing further trauma. It's one of several programs DCF has implemented since Gov. Laura Kelly came into office this year aimed at reforming the long-embattled foster care system.
The social workers being trained on Friday came from DCF, the state's two private contractors, and advocates from the community, said Tanya Keys, deputy DCF secretary. A strategic plan will be formed next month, while training is being implemented across the state, she said.
"The idea is that (social workers) go back and start planting these seeds, talking about these concepts and we'll get materials out to them so we can start that readiness for implementation," Keys said.
Kevin Campbell, founder of the Center for Family Finding and Youth Connectedness, trains about 100 Kansas social workers Friday in a national model called "Family Finding." Credit Evert Nelson / The Topeka Capital-Journal
Campbell, founder of the Center for Family Finding and Youth Connectedness and a former foster parent, began his research in 2000 after years of hearing "This kid's got nobody."
He found that most foster children actually have a large family and that if they could be connected with five to eight adults who would make a "permanent relational commitment" to the child, it could change outcomes.
"The training is really about, how do you heal children who have had such harm done to them?" he said. "And importantly, how do you heal the whole family? Because this kind of generational experience has to stop somewhere."
The training was sponsored by the Casey Foundation and Aetna Better Health of Kansas, which provides health care services for the state foster care system. Kellie Hans Reid, foster care coordinator with Aetna Better Health of Kansas, said research shows that traumatic experiences affect children's health.
Groups of Kansas Department for Children and Families' social workers at a 'Family Finding' boot camp on Friday at the Topeka Capital Plaza Hotel. Credit Evert Nelson / The Topeka Capital-Journal
"That, in turn, will affect their life course and their mortality, their metabolic issues, their cardiac issues," she said. "What we know is that trauma affects the body."
After the training this week, the team of social workers went back to the 17-year-old boy they'd been working with. He had told them he didn't have anyone in his life to help, but through talking with him about people from his past, social workers found some — including a former school principal and a former foster father who taught him jujitsu, a sport he loves.
The social worker, who could not be identified because she works undercover to find missing foster kids, said she was trying to "give him a family, like it doesn't have to be blood, just someone who cares about him."
"He went from having two of us," she said, "to having 26 of us in this week."
Peggy Lowe is a reporter at KCUR and is on Twitter at @peggyllowe.


Hotel Meyrick is an elegant four star hotel located in the fashionable Eyre Square in Galways city centre. The hotel combines a stunning Victorian hotel with a superb convenient location, the delights of Galway are right on your doorstep. Enjoy luxurious accomodation, a fine range of bar and dining options, soothing spa packages and treatments.


This page contains IGN's Walkthrough for Burlap Is the New Stripe, the twelfth main quest of The Witcher 3's first DLC expansion, Blood and Wine.
In order to get to this quest, in The Night of Long Fangs, go to Syanna instead of Orianna. In Beyond Hill and Dale, do not obtain the ribbon from the Little Flint Girl. This will get Syanna killed in Tesham Mutna.
Looks like Anna has thrown you into jail. After talking to another prison mate, you'll have control of Geralt.
The Perks of Being a Jailbird side quest can be missed here! As soon as you gain control of Geralt, turn around and use your Witcher Senses to find a note hidden in the wall. Turn back around and grab the needed hammer and chisel from the nearby cart and use it in the area where you found the note. After a week passes in the prison (part of story), return to this spot to grab a painting.
Walk downstairs and use your Witcher Senses to find soap near the stairs and the dirty clothes opposite of the wash tubs. Grab both and place them in the tub. Grab the nearby stick and start giving them a whirl.
Remember the guys you beat up back in Where Children Toil, Toys Waste Away? They're back and ready for a rematch. Luckily for you, these guys are an even bigger pushover than before, so this should only take a few seconds.
A week will pass and a guard will summon you out of your cell. Follow him around the prison until he finally takes you to Damien. Still upset of recent events, Damien will begrudgingly release you as Dandelion has shown up and convinced Anna to let you go.
From here you'll meet up with Regis and have the option to pursue who the final victim was supposed to be, or skip straight to Regis and Geralt drinking at the cemetery.
Make your way over to the bootblack boy and question him further about the notes he received earlier on in the game. From there, follow the marker on your map to make your way to the beggar's shelter.
Get through some dialogue and cutscenes and you'll be thrown into a fist fight. At this point in the game, you so much as sneeze and these two thugs will be down. Chatter some more, and you'll eventually learn that Anna was to be Syanna's final victim. You now have the option to go and tell Anna about the truth. Otherwise, head to Regis to end the mission.
Run over to the cemetery where Anna is grieving. After telling her the truth and seeing a conflicted and grieving Anna, the duchess will harshly send you on your way, leaving you to go to Regis at the other cemetery. This will lead to the Be It Ever So Humble quest.


text:
'use strict'

/**
 * System controller for functions such as /about and /monitor
 */
const os = require('os')

const log = require('kth-node-log')
const { getPaths } = require('kth-node-express-routing')
const language = require('kth-node-web-common/lib/language')
const errorHandler = require('kth-node-web-common/lib/error')
const registry = require('component-registry').globalRegistry
const { IHealthCheck } = require('kth-node-monitor').interfaces

const version = require('../../config/version')
const packageFile = require('../../package.json')
const i18n = require('../../i18n')

const ldapClient = require('../adldapClient')
const api = require('../api')
const config = require('../configuration').server

/**
 * Adds a zero (0) to numbers less then ten (10)
 */
function zeroPad(value) {
  return value < 10 ? '0' + value : value
}

/**
 * Takes a Date object and returns a simple date string.
 */
function _simpleDate(date) {
  const year = date.getFullYear()
  const month = zeroPad(date.getMonth() + 1)
  const day = zeroPad(date.getDate())
  const hours = zeroPad(date.getHours())
  const minutes = zeroPad(date.getMinutes())
  const seconds = zeroPad(date.getSeconds())
  const hoursBeforeGMT = date.getTimezoneOffset() / -60
  const timezone = [' GMT', ' CET', ' CEST'][hoursBeforeGMT] || ''
  return `${year}-${month}-${day} ${hours}:${minutes}:${seconds}${timezone}`
}

const started = _simpleDate(new Date())

/**
 * Get request on not found (404)
 * Renders the view 'notFound' with the layout 'exampleLayout'.
 */
function _notFound(req, res, next) {
  const err = new Error('Not Found: ' + req.originalUrl)
  err.status = 404
  next(err)
}

// this function must keep this signature for it to work properly, next param is needed.
// eslint-disable-next-line no-unused-vars
function _final(err, req, res, next) {
  const statusCode = err.status || err.statusCode || 500
  const isProd = /prod/gi.test(process.env.NODE_ENV)
  const lang = language.getLanguage(res)

  // Use error pages from kth-node-web-common based on given parameters.
  errorHandler.renderErrorPage(res, req, statusCode, i18n, isProd, lang, err)
}

/* GET /_about
 * About page
 */
function _about(req, res) {
  const { uri: proxyPrefix } = config.proxyPrefixPath
  const paths = getPaths()

  res.render('system/about', {
    layout: 'systemLayout',
    title: `About ${packageFile.name}`,
    proxyPrefix,
    appName: packageFile.name,
    appVersion: packageFile.version,
    appDescription: packageFile.description,
    monitorUri: paths.system.monitor.uri,
    robotsUri: paths.system.robots.uri,
    gitBranch: JSON.stringify(version.gitBranch),
    gitCommit: JSON.stringify(version.gitCommit),
    jenkinsBuild: JSON.stringify(version.jenkinsBuild),
    jenkinsBuildDate: version.jenkinsBuild
      ? _simpleDate(new Date(parseInt(version.jenkinsBuild, 10) * 1000))
      : JSON.stringify(version.jenkinsBuildDate),
    dockerName: JSON.stringify(version.dockerName),
    dockerVersion: JSON.stringify(version.dockerVersion),
    language: language.getLanguage(res),
    hostname: os.hostname(),
    started,
    env: process.env.NODE_ENV,
  })
}

/* GET /_monitor
 * Monitor page
 */
function _monitor(req, res) {
  const apiConfig = config.nodeApi

  // Check APIs
  const subSystems = Object.keys(api).map(apiKey => {
    const apiHealthUtil = registry.getUtility(IHealthCheck, 'kth-node-api')
    return apiHealthUtil.status(api[apiKey], {
      required: apiConfig[apiKey].required,
    })
  })
  // Check LDAP
  const ldapHealthUtil = registry.getUtility(IHealthCheck, 'kth-node-ldap')
  subSystems.push(ldapHealthUtil.status(ldapClient, config.ldap))

  // If we need local system checks, such as memory or disk, we would add it here.
  // Make sure it returns a promise which resolves with an object containing:
  // {statusCode: ###, message: '...'}
  // The property statusCode should be standard HTTP status codes.
  const localSystems = Promise.resolve({ statusCode: 200, message: 'OK' })

  /* -- You will normally not change anything below this line -- */

  // Determine system health based on the results of the checks above. Expects
  // arrays of promises as input. This returns a promise
  const systemHealthUtil = registry.getUtility(IHealthCheck, 'kth-node-system-check')
  const systemStatus = systemHealthUtil.status(localSystems, subSystems)

  systemStatus
    .then(status => {
      // Return the result either as JSON or text
      if (req.headers.accept === 'application/json') {
        const outp = systemHealthUtil.renderJSON(status)
        res.status(status.statusCode).json(outp)
      } else {
        const outp = systemHealthUtil.renderText(status)
        res.type('text').status(status.statusCode).send(outp)
      }
    })
    .catch(err => {
      res.type('text').status(500).send(err)
    })
}

/* GET /robots.txt
 * Robots.txt page
 */
function _robotsTxt(req, res) {
  res.type('text').render('system/robots')
}

/* GET /_paths
 * Return all paths for the system
 */
function _paths(req, res) {
  res.json(getPaths())
}

/*
 * ----------------------------------------------------------------
 * Publicly exported functions.
 * ----------------------------------------------------------------
 */

module.exports = {
  monitor: _monitor,
  about: _about,
  robotsTxt: _robotsTxt,
  paths: _paths,
  notFound: _notFound,
  final: _final,
}

redpajama_set_name: RedPajamaGithub


text:
NGOs, INGOs facing tough rules and regulations in Pakistan
作者: Nasir Aijaz on 26 October , 2017.
类别: All, Middle East
标签: INGO, ngo, Pakistan
Pakistani citizens fleeing terrorist bombing in Kuram, Pakistan. (Photo: Newsis)
The local as well as international non-government organizations operating in Pakistan have recently been receiving strange signals from the government. First, the government began scrutinizing NGOs and INGOs working in different fields across the country and then devised the new strategic policy of INGO registration besides also introducing strict terms and conditions for local NGOs that encompasses auditing of funds and imposition of taxes.
It all started back in October 2015 when the government announced its policy for regulation of INGOs in Pakistan, which only worked to further deteriorate the difficult working conditions many international humanitarian and human rights groups found themselves in. The new regulations required all INGOs to register and obtain prior permission from the Ministry of Interior to carry out any activities in the country and restricted their operations to specific issues in certain geographical areas. The Ministry of Interior is broadly empowered to cancel registrations on grounds of "involvement in any activity inconsistent with Pakistan's national interests, or contrary to Government policy". Previously, organizations were registered through the Securities and Exchange Commission of Pakistan (SECP), which focused primarily on financial oversight of INGOs.
"NGOs working against strategic, security, economic, or other interests of Pakistan will have their registration cancelled,"—a statement found in a press release of the Interior Ministry categorically denying acceptance to organizations that failed to meet requirements.
Earlier this year, the Interior Ministry initiated the process of scrutiny and registration, granting approval to 73 INGOs to continue working in the country. Meanwhile, 23 INGOs were refused permission to operate because of issues with their previous performance and/or due to certain activities falling outside their domain and stated purpose of their organization. 20 or so cases of INGO registration were further deferred; they still await consideration by the Interior Ministry.
On the same line, all INGOs were directed to receive their annual financial audits from any one of the audit firms approved by the State Bank of Pakistan. Cost of audits would be the responsibility of said INGO.
According to the Interior Ministry, the registration of INGOs was critical for the security of the state. And acting as per new policy, the Interior Ministry in its recent move ordered Medicins Sans Frontieres (Doctors Without Borders, MSF)—a medical charity that has for 14 years been working in the war-torn Kurram district of Federally Administered Tribal Areas (FATA) bordering Afghanistan—essentially to "pack up and leave". The move was obviously part of a larger clampdown on the operations of local and international NGOs across the country. This action resembles what occurred a few years back when the government issued a "pack up" order to Save the Children, an organization that had been working in the Pakistan for decades. Later, however, under international pressure, the Pakistani government allowed the organization to continue working but at a very limited level. The result was that overall international charity operations declined to a dismal twenty percent.
Such recent actions against INGOs have been sending rather confusing mixed messages. Requirements and demands that all INGOs be registered according to Pakistani standards and be monitored for their work may be understandable, but a number of NGOs have been forced to shut any and all activity. Many have been restricted from working in the provinces of Balochistan, Khyber Pakhtunkhwa, and southern regions of Pakistani Punjab.
Another severe blow that has been dealt on non-profit groups is a new tax that has made humanitarian agencies cut back on services to some of the most vulnerable groups in the nation.
Pakistan imposed a tax in June this year on NGOs that spend 15 percent or more of their budget on administrative costs. Those costs would be taxed at a rate of 10 percent, as would any remaining money at the end of the fiscal year if it totals more than 25 percent of the organization's entire budget.
Critics see the new tax as part of an ongoing crackdown on civil society, which has seen NGOs stripped of their charity status, shut down, accused of promoting blasphemy and pornography, and forced into a labyrinthine registration process. The government denies allegations of crackdown and says the new law is simply intended to cut down on wasteful organization activities to make sure that donor money given to charities actually makes it to those in need.
"We have imposed taxes on the NGOs to stop misuse of the funds," said Ishaq Dar, a senator who was finance minister until the incumbent cabinet was dissolved after a 28 July Supreme Court ruling forcing Nawaz Sharif to step down as Prime Minister for charges of corruption. Dar was again chosen for the same position by the interim Prime Minister despite corruption cases.
"If the NGOs keep working in the prescribed limits, they won't have to pay the taxes," Dar had said in an interview. "Instead, they will actually have more money to spend on humanitarian programs."
On the other hand, Nasir Panhwer, who heads the Center for Environment and Development in Sindh Province, told The AsiaN, "It's not so simple," adding that the government's imposition of a tax on agencies that spend less than 75 percent of their yearly budgets on programs would damage current charity efforts.
"The government's taxes will definitely force NGOs to abandon numerous projects," he said, further saying that some donors have already suggested they may cease their funding as they do not want funds to be used to pay the new tax.
"You may judge the gravity of situation from the latest reports that besides 'taxing NGOs for helping the poor', the government has decided to monitor their activities through the Intelligence Bureau," Panhwer said in reference to media reports, concluding, "This would leave a very adverse effect on NGO operations."
Similar views were expressed by an official of another NGO member who asked that his identity not be revealed for fear of any government retaliation, "You know the situation and I cannot take the risk."
According to a report by the United Nations Integrated Regional Information Network (IRIN), the finance minister of Pakistan altogether denied that the government has been cracking down on civil society in order to silence opposition.
Still, civil society leaders beg to differ. Among the major incidents that have been brought to light, they point to an addition to the latest tax move—heightened investigations launched earlier this year into allegations that multiple NGOs were promoting blasphemy and pornography.
Although India has likewise imposed similar regulations on NGOs and INGOs such as issuing notices for over 1200 NGOs to be repositioned. International bodies like Human Rights Watch consider Pakistan's latest policies to go against basic rights to freedom of association. "Pakistan's government has the responsibility of preventing fraud, financial malfeasance, and other illegal activities of NGOs, but Pakistan already has laws and regulations that address such concerns," Human Rights Watch said in a recent statement, going on to say, "The new regulations will severely restrict rights to freedom of association and expression for Pakistanis who are working for INGOs, as well as for foreign nationals. These rights are protected under the Pakistani constitution and international law."
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Pakistan condemns nuclear test conducted by North Korea
Military standoff between India and China at Doklam Plateau
Pakistan's apex court ousts country's remier over corruption claims
Pakistan: Politics of Power for Power
By Nasir Aijaz
Pakistan, Representative of The Asia N/Magazine N


The Wizards are back where they were before Michael Jordan dropped into town for a therapy session.
They have a couple of players and a lot of questions, plus a sinking feeling going into the 82-game season.
They showed themselves to be careless with the basketball and among the dregs of the NBA in the preseason. The carelessness has fomented an irritability in the new Jordan and prompted a remedial math class. As shocking as it may be to the peach-fuzz brigade, there is a finite number of possessions in a 48-minute game.
The dread is worse than the team's 2-6 record in the preseason.
Jerry Stackhouse, who used to be an All-Star, is out of commission until December, perhaps longer, depending on how responsive his right knee is to rehabilitation.
Stackhouse is not inclined to rush himself back into service, a fair approach around what promises to be an incidental point on the calendar, whether December or January. In either case, the Wizards are apt to be hunkered down by then, trying to ward off the mental fatigue of a 25-win march.
Abe Pollin, the old owner thought to be out to eternal lunch, responded well to the old Jordan's nameless hit men last spring.
Pollin hired a competent general manager who was willing to work and live in Washington, took a chance on the fashionable assistant of the moment, lured a 21-year-old potential star from the West Coast, re-signed Stackhouse and perhaps found a gem in the draft in Jarvis Hayes.
Pollin made enough good moves to put the Wizards in playoff contention, as playoff contention is loosely defined in the summer months.
The first snapshot of the Wizards shows the team looking younger than feared and the leading scorer on crutches.
The curse of the Wizards may not rise to the weepy level of the Bambino in Boston and the goat in Chicago, but it is real enough, going back to the abbreviated careers of Jeff Ruland and Hot Plate Williams in the '80s and the legal difficulties of Chris Webber and Rod Strickland in the '90s.
The Wizards have not been to the playoffs since 1997 and have not won a playoff series since 1982. Neither streak appears in jeopardy of ending this season.
This is assuming that Kwame Brown's maturation process remains less filling. The keepers of the old Jordan's flame already have stuck Brown in the company of LaRue Martin, arguably the worst No.1 overall pick ever in the NBA Draft.
This is hardly fair, but fair was hardly part of the process the last two seasons, with Jordan hoisting jumpers from afar and Doug Collins swooning after each attempt.
Brown was not gritty enough for Jordan's tastes, as those tastes were refined in Chicago by Charles Oakley, Horace Grant and Dennis Rodman.
Brown's personality makeover was destined to fail, and it was Jordan's failure between tee shots going into the 2001 NBA Draft. A bogey can be distracting.
You can't teach grit. Or hands, for that matter.
Both Brendan Haywood and Jahidi White are still around to confirm the latter.
There is a distant hope, either next season or the season after that one, if patience is exercised with the team's core. Brown, Gilbert Arenas and Jared Jeffries are 21 years old, Hayes is 22, Haywood is 23 and Etan Thomas and Juan Dixon are 25.
Not all these players are destined to stay together the next couple of seasons, of course, but the foundation is genuine enough to imagine the Wizards eventually overcoming a generation's worth of false promises.
That prospect requires a healthy Stackhouse, who is 28 but possibly going on 38 in knee years.
The Wizards were bound to be fragile this season following the self-centered vision of the old Jordan.
The hint of encouragement was dependent on the good health of Arenas and Stackhouse, the team's two leading players.
Two is sometimes enough in the Eastern Conference, as the Celtics demonstrated the last few seasons.
The Wizards, alas, almost typically, are minus one, which puts yet a greater burden on Brown to deliver a quality season.
That is asking too much even now, in season No.3 for Brown, the first two, in hindsight, best managed with cotton stuffed into his ears.
We now go from cotton to possibly blindfolds, another useful accessory if the season turns ugly.


text:
HomeMarketsDrug-DeliveryAccelerating Trends Toward Patient-Administered Biologic Therapies
Accelerating Trends Toward Patient-Administered Biologic Therapies
Image courtesy of Oliver Design
How can drug delivery advance beyond the traditional vial and syringe?
Mark Foster | Dec 22, 2021
The pharmaceutical industry has followed a path that clings to traditional medicine as it simultaneously pursues innovation. Perhaps no area of the business illustrates this as clearly as that of parenteral administration of therapeutics. What is the status of legacy versus disruptive drug-delivery methods? Where should we be focusing our attention as we serve the pharma client seeking guidance on parenteral technologies, pitfalls, and profitability?
As a company focused on custom packaging design, we see our customers struggle with this every day—traditional methods ensure a quick go-to market strategy, while innovative delivery methods take longer (but could be a clear point of differentiation in a crowded market). We often see new drug therapies enter the market with traditional packaging and delivery methods; then, as the medicine gains traction and popularity, the delivery method is often reviewed and even redesigned.
The Traditional "Shot," Tried and True
As we know, traditional injections rely on syringes and hypodermic needles filled from ampoules and vials. The overall design, materials, and delivery of hypodermic injections have remained largely unchanged for more than 70 years. And even as new delivery technologies have emerged, the vial and ampule markets continue to show strong forecasts. Current forecasts predict steady growth through at least 2028.
Several factors contribute to the enduring demand. Low cost, universal use, and proven reliability generally make the hypodermic injection the fastest way for medicines to reach market in the process of conducting clinical trials. Once a formula has been successfully established and marketed, moving on to prefilled syringes is a shift that can be explored.
The Prefilled Syringe
The popularity and still-rising demand for the prefilled syringe (PFS) make it hard to believe that it has been on the market for more than 40 years. Who remembers the first PFS hitting the market as a breakthrough heparin delivery method? Many of us still feel like the PFS is relatively new! The advantages of a delivery system that serves as both the packaging and the administration are easily recognized. There are two basic PFS types: those with and without a cartridge. Prefilled syringes with cartridges are often used in vaccine delivery, while staked-in (integrated needle as part of the syringe) serve emergency needs. Prefilled syringes without an integrated needle require the attachment of a needle. The newest design option is the dual-chamber PFS that allows two drugs to be co-delivered or pairs a lyophilized drug with a diluent. The convenience, rapid administration, accuracy, drug waste reduction, and enhanced patient safety offered by the various forms of PFS are often preferred in both clinical and patient-managed care settings.
And if the PFS is not really "new" anymore, then what drives the rapidly expanding demand? Certainly, continued advancements in design versatility and increasing numbers of biologics suited to the PFS are factors. Additionally, emerging high-tech materials (i.e., polymers that don't interact with contents) continue to mitigate some PFS challenges (i.e., stability, siliconization, tungsten residues, glass stress). It is reasonable to conclude that current limitations will continue to be eclipsed by innovation.
Auto-Injectors
The discussion of prefilled syringes naturally leads to the next parenteral route, the auto-injector. The auto-injector was originally developed in the 1970s to deliver nerve gas antidote for the U.S. military. Developer Sheldon Kaplan also created the mainstream version to deliver epinephrine for anaphylaxis, with the famed EpiPen receiving FDA approval in 1987. The pens are fast, easy for anyone to use with no training, and can effect life-saving outcomes. Patients and caregivers report ease of use and significantly reduced administration discomfort, further galvanizing the interest of pharmaceutical clients in new opportunities for auto-injection delivery devices. Human factor testing in at least one study supports that while many patients will be successful in self-administering injections from a PFS, patients given auto-injector devices demonstrated total success, even without additional training for the device.
Auto injectors (both disposable and re-usable, with the former capturing the largest share) are also gaining ground in a wider range of treatment areas, including MS, RA, diabetes, and heart disease. Auto injectors are predicted to reach 104.9 billion by 2025 (CAGR 17.9%). Increasing instances of anaphylaxis, generic availability, upcoming expiry of biologics patents, and more targeted medicines all play a role in the future of auto injectors.
Intranasal Delivery
And finally, the newest delivery method that has taken the stage during the last decade has been intranasal drug delivery. There is a lot of potential. Absorption takes place through nasal lymphoid tissue. Highly vascularized and easily accessible, intranasal delivery offers high bioavailability, rapid absorption, and avoidance of first-pass effect common with gastrointestinal administration. There is also the potential compliance advantage of low patient resistance to intranasal delivery. Nasal drops and sprays are already familiar and perceived as painless and well-tolerated, adding to the appeal of further R&D for this method. As with all parenteral drug-delivery routes, intranasal is not without challenges and limitations. Dosing, for example, is limited as the absorption area is small compared with that of other routes. Additionally, only certain drug types are currently suited to intranasal delivery for a variety of reasons. It is a topic to watch—and investigate—as we go forward.
In conclusion, and in our opinion, it is possible that demand for original syringe, hypodermic needle, and drug transfers from vials and ampoules could finally see declining demand in the not-so-distant future, but they will likely always have a purpose and place. There are advantages to starting with a tried-and-true solution and progressing to a more-innovative drug-delivery method down the line. Speed, security, and patient familiarity are all advantages to starting with the more-traditional solution. Packaging takes on a more important role as therapies transition from vials to patient-administered delivery systems. Gaining market knowledge and time allow for clients to refine and innovate in their next round of packaging. Other parenteral drug-delivery routes, including those less studied and not widely implemented to date, hold exciting potential for pharma clients and patients. There is no limit to the refinements and possibilities that could transform how medicines are introduced into and function within the human body in the months and years ahead.
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text:
Alumnus Spotlight: Patrick Pickens
by Isabel Haglund | Posted on February 9, 2022 February 9, 2022
Sacred Heart University alumnus Patrick Pickens believes that if not for his time at Sacred Heart and all the work he put into his studies and career, he would not be where he is today publishing his first book.
At Sacred Heart, Pickens was a writer on The Spectrum his junior and senior years.
"That was my first writing opportunity," said Pickens. "I think my whole time at Sacred Heart was essential, but especially The Spectrum."
Pickens initially wanted to be a broadcaster, but his plans changed.
"I began writing sports for The Spectrum and that whole thing about being a broadcaster flipped," said Pickens. "I decided I wanted to get into sports writing, and it was really sort of learning that this was something I could do and that I had a talent for."
In 2007, Pickens graduated from Sacred Heart University and began working at the Fairfield Citizen as the sports editor. While he was there, he covered high school hockey in Connecticut and noticed that fans were wearing Hartford Whalers apparel, even though the team left Hartford in 1997.
"The fans, the kids, the players, they were all wearing Whalers stuff," said Pickens. "It had been 11 years since they left Connecticut, and people were still wearing hats and shirts."
Pickens believed there was a deeper story as to why people were still sporting the team's apparel. He started with little knowledge about who The Whalers were and began researching and gathering information about their franchise.
"At some point, it stopped becoming a networking opportunity," said Pickens. "It started becoming a really remarkable story that I knew a lot about and learned a lot about."
According to a press release from Sacred Heart, Pickens left the Fairfield Citizen in 2013 and began to work for The New York Times doing freelance work with the New Jersey Devils, New York Rangers and the Islanders. Whenever he found free time in his busy life, he was researching and writing about the Whalers.
Pickens wanted this book to be the best it could be and dedicated his energy towards it.
"I knew that I wanted to get anecdotes and stories and comments from as many high-profile people as possible," said Pickens. "And especially people who knew and lived the story."
"The Whalers: The Rise, Fall and Enduring Mystique of New England's (Second) Greatest NHL Franchise" written by Pat Pickens was published in Oct. 2021, after 10 years of writing and research.
"I'm really excited about how it came out," said Pickens. "I was so obsessed with doing this the right way for the people that lived it, and then the people that were learning about it could really learn something."
Over the past decade and a half, Pickens has grown into his career and is now achieving his dreams, while giving back to where they first began. Pickens created a lot of his own success, but he believes he owes a great deal of it to Sacred Heart University.
"I went to Sacred Heart and learned a lot of stuff and my career really took off," said Pickens. "I want to give back to the school whenever I can."
Featurespat pickens patrick pickens shu alumni shu SCMA
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If you are moving in KY3, KY1, KY2 and KY9 then get some peace of mind by getting your packing done by our dedicated teams.
No matter how far you are traveling, the mechanics of moving a family or a business from A to B doesn't change which is why the leading London removals company is now helping people leave KY7, KY13, KY10 and KY14 to start new lives in Spain, Italy, Germany and France.
Most removal companies do very little for people moving in KY16 other than turn up on moving day with a delivery lorry and expect you to be completely ready for your house or office move.
However Removals Man and Van is one of very few moving companies which can take you through the whole process of planning and preparing for your move, and in Newport-On-Tay, Saline and Cardenden we can come and visit you free of charge before your big day to help plan and to do a stock check of what we are taking.
Something like furniture moving or IKEA deliveries. In Leuchars, Kinghorn, Kingseat, Strathkinness and Newport-On-Tay you can call on the leading London removals company to help you with these jobs because who better to trust with a small job than the biggest name in the removals business?
That is why when you are getting ready to move in Leuchars, Blairhall, Coaltown of Balgonie, Kirkton of Largo or St Andrews the packing part of the project is often the most daunting.


text:
Q: Remove specific elements n times in python I want to remove an specific element from the list n times, if a put 7 I want to remove all sevens. I'm trying to run this code but get me an error:
elements = [1, 2, 3, 4, 4, 5, 6, 5, 7, 7]
valor = int(input('type a value: '))
for i in range(len(elements)):
    if (elements[i] == valor):
        elements.remove(valor)

print(elements)

IndexError: list index out of range

A: You can make use of the list comprehension like this:
elements = [1, 2, 3, 4, 4, 5, 6, 5, 7, 7]
valor = int(input('type a value: '))
print([e for e in elements if e != valor])

A: You should not remove values during a for each loop.  This will work:
elements = [1, 2, 3, 4, 4, 5, 6, 5, 7, 7]
newElements = []
valor = int(input('type a value: '))
for i in elements:
    if (i != valor):
        newElements.append(i)
elements = newElements
print(elements)

redpajama_set_name: RedPajamaStackExchange


From the always excellent Silk Road Economy blog: "China overtook the United States earlier this year as the world's largest exporter to the Middle East. It's the first time the United States has lost its number one ranking since at least the 1960s, or as far back as there is data available. I haven't seen the figure reported in the media. But I don't expect to wait long. This is the type of easy to understand statistic that will rattle doors in Washington. I can see the cable news stations going into hyper-drive."


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