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Just the ticket for Rangers fans?
February 22, 2017 February 22, 2017 Steve Sayce
So we've just had another 'big reveal' from the club regarding season ticket prices for next season. And in all fairness for existing holders renewing before 31 May it's pretty good news. In summary:
• Renewal prices frozen
• Interest-free direct debit installments
• 'Bounty' of £20 QPR Cash when you 'refer a friend' who buys a new ticket.
Announcements such as this from the club are often greeted with much gnashing of teeth with concerns over increases. In the case of last year the attempt by the club to change the timing of renewal deadlines also proved unpopular.
This year? Well it feels like a step in the right direction. QPR is not a cheap club to support and undoubtedly stats which support or deny that are likely to be bandied around on social media in the weeks to come.
One positive is that the club has opted to go for a later end to the renewal window than planned – they were originally were looking at the end of March. Whatever the reason for the selection of the end of May, whether it being a true consideration of the fans, or perhaps a delay for an improvement in the club's fortunes, it is more than welcome.
The direct debit scheme also sees an end to the disliked arrangement with Zebra Finance. Interest-free payments over ten months are bound to help some people spread the cost.
One revelation today will please kids, parents, and the 'big-kids' amongst us – personalised seat labels are returning next season. A small thing, but makes a huge difference for some people – 'my seat, my club'.
Don't throw your current season ticket away in May though – it will be used again next year. The club is making some sensible savings here.
Interestingly walk-up prices for next season haven't been published yet. I hope that those are as equally reasonable. Whilst QPR has a rump of fans who will attend game in and game out, casual sales remain an important part of the matchday income and must not be priced out.
Mind you – one of the hardest parts of the 'sell' of season tickets to fans will be the possibility of a repeat of this season's fixture disruption. TV's stranglehold over the game now means months without a Saturday 3pm home fixture is an issue almost impossible for the club to resolve.
Blogs. permalink.
11th March 1972: Birmingham City (0) – QPR (0)
On this Day in 1968: A 1-1 Draw at Bolton, which included a Half-Time Punch-Up!
7 thoughts on "Just the ticket for Rangers fans?"
paul freeman says:
Hi Steve, how do you know about the seat labels ? I complained about this and will be pleased if its back. we have 3 seats together with the family surname so was peed off when they were removed. thanks Paul.
Paul Shrimpton says:
I'm very much a 'casual attendee' due to life and work commitments, so the earlier the walk-up tickets are announced, the better. But I definitely agree with the sentiment behind the article and announcements. My Club. It's not just yours, it's R's…
Steve Sayce says:
Hi Paul F – It was announced here…
"The club are also pleased to confirm the return of personalised seat labels, which will be in place by September 1st."
http://www.qpr.co.uk/news/article/2016-17/qpr-201718-season-tickets-on-sale-3587535.aspx
Paul Finney says:
Prices are something that can build or smash a fan base i think prices being held and the ways to pay are good and helpful to both of that.
Walk up prices are massive to all who want to see the club grow as is prices for family groups.
In these days where every penny counts it is good the clubs are in touch with that and i hope all clubs in this league think of or agree on one price for all away fans and famlies.
Cool thanks just seen it on the website they didn't put that part in the email they sent out ;o) a good move I think.
Michael O'Halloran says:
Just renewed and it's great that the club is offering a direct debit option to spread the payments.The early bird price freeze is very welcome too.Im glad also that our names will be back on the seats next season,finally using our present season ticket cards and reactivating them instead of issuing new ones is a sensitive money saver.Well done qpr.
Sensible money saver lol


text:
shehla
Court directs Delhi police to issue 10-day pre-arrest notice to activist Shehla Rashid
A local court directed Delhi Police to issue a 10-day pre-arrest notice to activist Shehla Rashid in case she is to be arrested in connection with a case of sedition filed against her
Shehla Rashid
A local court here on Friday directed Delhi Police to issue a 10-day pre-arrest notice to activist Shehla Rashid in case she is to be arrested in connection with a case of sedition filed against her for social media posts allegedly defaming the Indian Army.
The order by Additional Session Judge Satish Kumar Arora came after the court considered the nature of allegations against Rashid and the submission of the Investigating Officer who told the court that the investigation was still at a preliminary stage.
"Keeping in view the nature of allegations and also considering the submission of the IO that the investigation is at a preliminary stage, anticipatory bail application is disposed of with directions to the IO that if the need arises for the arrest of the applicant/accused, she be issued a 10-day pre-arrest notice," the court said in the order.
Rashid, a Kashmiri activist and former JNU student leader, has been booked on charges of sedition over her comments about alleged human rights violations in Jammu and Kashmir by the Army.
The Delhi Police's Special Cell had said that the FIR was registered on September 3 on a criminal complaint by Supreme Court lawyer Alok Srivastav who had sought her arrest.
In a series of tweets, days after the special status of Jammu and Kashmir was revoked in August, Rashid had claimed that the Army was indiscriminately picking up men, raiding houses and torturing people in Kashmir.
The allegations had drawn sharp reactions but Rashid had said that she was ready to give the evidence if the Indian Army holds an inquiry.
The Indian Army has officially rejected her claims and called them "baseless" and "unverified".
After the Army dismissed her claims, many accused Rashid of spreading fake news to disrupt peace in Kashmir.
shehla Kashmir jnu arrest sedition

redpajama_set_name: RedPajamaCommonCrawl


While Philips Hue HomeKit-compatible gear isn't officially expected until October 6, the A19 Starter Kit has begun appearing at various retail locations. Indeed, I literally got my hands on the v2 hub bridge. It's smaller and squarer than the existing model, with a nicer matte finish and generally more tasteful presentation… that is entirely irrelevant since you'll be plugging it into your router somewhere out of sight. There are three indicators, plus a glowing ring that surrounds the much larger pairing button.
As Philips moves the line to HomeKit, pricing of Hue bundles looks to remain unchanged (in the US, anyway). What's not yet clear, but should be revealed within the next 48 hours, is the cost of a standalone HomeKit bridge to retrofit the bazillions of Hue homes that sport iOS (like mine). Also unclear, as I'm pretty sure an App Store update is required, is the extent of Siri voice control. For example, will it best Amazon Echo's existing but limited (tho useful) Hue interaction?
UPDATE: The HomeKit replacement hub has popped up on Amazon for $60… But I'm waiting to learn more about Siri's capabilities before making my purchase.
Good recon, Dave. Did you actually buy the new hub or just touch it?
Stand alone HomeKit hub will run $60. I updated the post.
I just got the Hue Lux Starter kit today at Best buy on sale for $59.00. If I buy this bridge will it replace or work with the existing bridge?
Dave just saw that this item can be available for existing customers for $40.00 direct from Phillips.
I may just pick up another "Starter kit" — need to look around the house at likely fixtures.


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Complete what you have begun in us * that we might work for the fulfillment of your kingdom.* Not to us the glory,* but glory to you O God, through Jesus Christ, your Son* and our Lord; * Father, Son and Holy Spirit,* you are our God, living and reigning forever and ever.


Learn to use our software with an open-class or on-demand training.
In this training, you will get an understanding of the ins and outs of auditing SAP authorizations in CSI Authorization Auditor.
Next up: 03-05 June 2019 & 07-09 October 2019.


Fixation is proud to be an official Support Centre for Fujifilm Professional Services. We can offer sensor cleaning and cosmetic repairs to the Fujifilm X system cameras.
FPS members can take advantage of the scheme benefits with regards to guaranteed turnaround times and loan equipment. For more information on FPS, click here.
Prices start from £36 for sensor cleaning and from £45 for service work.
If your camera is not listed above, we may still be able to provide a sensor cleaning service. Please contact admin@fixationuk.com for more info.
FPS members can take advantage of free loan equipment if the repair time exceeds Fujifilm's stated turnaround.
We can facilitate any in-depth repairs with Fujifilm on your behalf.


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Smith Leaves 17U Pakmen in Good Hands
Pakmen Volleyball Coach Matt Harris (right) and 16U Champions Team
By DAVID WINER
Kelly Smith didn't have to search far and wide for a replacement when he decided to take a one-year break from coaching late last year.
While guiding his 16U Pakmen team to back-to-back Provincial and Eastern Canadian indoor titles, the Pakmen Volleyball Club founder and President could rest comfortably knowing his charges would remain in good hands come the 2017 indoor season.
Smith didn't have to look any further than the Volleyball Canada Centre of Excellence (VCCE) program run out of the Pakmen club to find a coach of all coaches, Matt Harris.
Harris has made volleyball a life-time commitment and passion, with close to 20 years of experience teaching and coaching at the university, high school, club and high performance levels.
While Harris will continue to act as assistant coach for the Ryerson Rams men's volleyball program under the helm of Dustin Reid, he will shift over from the VCCE program to head up the 17U Pakmen.
Spending much of the summer coaching the Team Ontario 18u Boys team at both the US High Performance Championships in Fort Lauderdale, Florida, as well as the Canada Games in Winnipeg, Harris hasn't had time to get acquainted with last year's players. However, he is certainly familiar with most of the club members through the VCCE program.
He helped recruit Pakmen graduates Jordan Baric and Navreet Singh Suhan to the Rams this off-season, and coached Suhan Navreet, Saad Shaikh, Matthew Powell and brothers Cole and Xander Ketrzynski on the 18U provincial team which won gold in the International Division in Florida, and is currently competing in Winnipeg.
Team Ontario knocked off some powerhouse teams to capture the gold, including an American Youth National team preparing for the World Championships, as well as two experienced California teams, and leading the way was Xander Ketrzynski, who was named tournament MVP.
"I have not spoken to any players yet, (because) I've been away all summer," said Harris, adding, "I'm very excited to work with this team. They are very talented and committed to getting better."
While tryouts for the team will take place in September, it's expected most of the players from the past two championship seasons will be returning. But Harris isn't fazed by the pressure that will come with taking over such a successful team.
"Pressure for me is whether I can succeed in turning young teenagers into young adults and getting the team to play its best at the end of the year," said Harris.
Harris will have last year's assistant coaches Franco Rugosi and Alex Ketrzynski to lean on for support.
While Smith plans to step away from coaching for the upcoming season, he plans to return for the following indoor campaign.
And Smith is comforted with the knowledge he has a person he can count on running his group of champions.
"(Matt) is widely respected by both players and coaches in our sport and it's been a priority to get him on the Pakmen team," said Smith when he recruited Harris for the VCCE program. "His passion for the game, expertise in the sport, and integrity as a person fits perfectly into the Pakmen model. Every club wanted Matt, knowing he was coming available, and we are thrilled he chose Pakmen.
Harris will take over a mentally tough group of players that Smith credited as being "the most resilient" 16U team he has ever coached with no fewer than three comeback victories at the National Championships.
Leading the charge at last year's Nationals were Cole and Xander Ketrzynski's brother Trent, as well as Luca Nastase, who were named to the all-star team, as well as tournament MVP Peter Rugosi.
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A major migration and wintering area for migratory waterfowl. Populations of 125,000 mallards and 75,000 Canadian geese have been recorded. Features a Visitors Center, boardwalk nature trail and auto tour route. Fishing and limited hunting are permitted on the refuge. Free admission.


robertr.adams - Hunter Funeral Home, Inc.
Robert R. "Bob" Adams died Friday, June 9, 2006 in UPMC McKeesport Hospital. Born in Mahoning County, Ohio August 26, 1921, age 84. Of Elizabeth Township, he was a retired manager for Hilliard's Auto Parts. He was a member of St. John's Evangelical Lutheran Church, Aliquippa Lodge #375, F&AM, Al O Mon Forest #138, Tall Cedars of Lebanon, Syria Temple of the Shrine, Royal Arch Chapter #162, and was a WW II US Army veteran.
Son of the late William Floyd and Cloe Stevens Adams, he is survived by his wife, Helen Dingledine Adams, brother, Eugene Adams of Monaca, sister, Dorothy Siget of Conway, PA, also nieces & nephews.
Friends will be received in the Hunter Funeral Home, Inc., 1600 Coursin Street, McKeesport Sunday from 12-2 and 7-9 PM, where a service will be held Monday, June 12 at 11:00 AM with the Rev. Warren L. Smith officiating. Interment will follow in Jefferson Memorial Park, Pleasant Hills. The family suggests contributions to St. John's Evangelical Lutheran Church, 329 Ninth Avenue, McKeesport, PA 15132.


"24 Hours. A short period of time in the scope of eternity. 24 Hours Endurance Racing: a span of time longer than eternity."
In September 1999, after a hiatus of seven years, the WERA National Endurance Series reinstated its most grueling and demanding event, the 24 Hours of Willow Springs. A race will break some teams and reward those teams most tenacious and prepared.
Team EBSCO Suzuki Corona Extra came prepared with a Heavyweight Superstock Hayabusa that would win its class in this remarkable event, finishing 2nd overall, and a team that seems now, looking back, like one truly for the ages.
Aside from a small tear below the right knee puck, the Vanson Leather suit picutred left remains in almost new condition, having only been worn once by Curtis Adams exclusively for this event.
If you can't resist this exclusive opportunity, please contact us here.
Taking turns racing around the "fastest track in the west" that historic weekend were: Dave Deveau, Doug Polen, Curtis Adams, Andrew Trevitt, Cal Rayborn, Tom Montano and Mark McDaniel.


To become healthy is necessary now a day, and to feel good via a health point of view is the fundamental thing. To nurture your mind with the body you need Yoga in your life. You need more relaxing in your life and feel free from the tension you need to relax your body and mind and for that, you need the yoga classes Melbourne service. You can get the greater sense from the inner peace just because of the 10 minutes of the yoga, then just imagine if you do daily yoga then???
If you want to increase the flexibility, strength and balance between body and mind then you have to acquire the yoga whether you avail the group fitness training Melbourne service. To be energised, for the inner wellbeing and vitality improvements. The control of the breathing requires the proper method and technique.
At the start of the yoga classes Melbourne joining, you are stiff from the body but as time goes it will increase gradually. To stretch your body by accepting the different styles of the yoga, and it will help you to strengthen your body. People also join the group fitness training Melbourne class to get the flexibility of the body.
Get the proper fitness and to maintain the weight by just accepting the ancient yoga style such as Asana and if you do the perfectly you can definitely get the shape of the body. For the losing weight, the exercise is must and yoga will help to burn the calorie, and tone up the body.
To join the yoga classes is beneficial because it provides the self-motivation, self-development, self-inspiration and so many things. To get this, the yoga is helpful. People are seeking out for the meditation because it provides the relaxation plus motivation.
To get away from nature is not favourable and yoga will get you close to nature. To make your lifestyle healthy you have to relief your body, mind and overall health. To conscious about the environment is necessary because it will affect on your lifestyle at least in the future.
In the modern era, there are so many responsibilities people have daily, and they always get the stress from the everyday life. But the yoga has the quality of removing the stress. The feeling you will get after the de-stressing is notable such as "mindfulness" and relief.
There are many other advantages that you will get from the yoga group fitness training Melbourne classes.


SOUTHWEST COLORADO ― The Colorado Department of Transportation's (CDOT) Civil Rights Business Resource Center (CRBRC) will host a civil rights compliance training for contractors in Durango on Wednesday, February 20 from 8:30 a.m. to 5:00 p.m.
The CRBRC workshop will provide contractors with the tools needed to successfully maintain compliance in areas such as nondiscrimination, small business, and labor regulations which are required on all CDOT's highway and bridge construction contracts.
When: Wednesday, February 20, 2018, 8:30 a.m. ― 5:00 p.m.
Meal Update: Please note, lunch will be on your own.
CDOT has approximately 3,000 employees located at its Denver headquarters and in regional offices throughout Colorado, and manages more than 23,000 lane miles of highway and 3,429 bridges. CDOT also manages grant partnerships with a range of other agencies, including metropolitan planning organizations, local governments, and airports, and administers Bustang, the state-owned and operated interregional express service. Colorado Governor Jared Polis has charged CDOT to further build on the state's intermodal mobility options.


Plan your next trip in style with this 100% hand drawn custom Movie characters. You will not find these particular designs anywhere on the web. Comes in 4 different colors. Choose your character and custom name that goes below each character.
3. Add To Cart. On the next screen or during checkout this is where you choose the quantity of your order under the dropdown box. Change the "1" to how many tees you need and proceed with the checkout steps. For example change the "1" to "6" referring to 6 tees needed. Please note that the number of tees you inputted under notes must match the quantity of tees you ordered.


Hypno (Japanese: スリーパー Suriipaa) is a Psychic-type Pokémon introduced in Generation I.
Hypno is a human-like Pokémon with yellow skin. On the top of its head are large, cat-like ears. Its eyes are usually squinted, and lower down. It also has a large nose. On its neck, Hypno has a large white mane, which stretches completely around. Hypno also has human-like arms and hands, which both have five digits. It is also always carrying a small pendulum, which it uses in most of its Psychic based attacks.
Female Hypno have longer collar-fur than the males.
Seeing its sweeping pendulum can induce sleep in three seconds, even in someone who just woke up. Hypno have both the abilities Forewarn and Insomnia. Insomnia will prevent the user from falling asleep while Forewarn will show the attack of an opponent with the highest attack power.
All Hypno also have the skills to cause anything to fall asleep, and also have a high amount of power in hypnotic abilities.
Hypno is the evolved form of Drowzee, as of level 26.
When it is very hungry, it puts humans it meets to sleep, then feasts on their dreams.
To see the Egg Moves that Hypno can learn, refer to Drowzee.
Hypno first appeared in the anime episode Hypno's Naptime. In this episode, Hypno's abilities had a strange side effect on many of the children in the local town, causing them to run off to a secluded garden and act like various Pokémon.
Hypno's PokéDex entry tells about it accidentally taking a child away. A shirt was released in Japan showing it doing this very thing.
Because of this shirt being released in Japan, Hypno became part of Creepypastas, usually referred to as "Hypno's Lullaby".
Hypno's voice in the anime bears a striking resemblance to horror film icon Peter Lorre's, just as its pre-evolutionary form Drowzee's voice resembles Bela Lugosi's.
Hypno and its pre evolution, Drowzee, are both based on a nightmare eating spirit from Japanese folklore called the Baku.
Hypno's English name is taken from the part, Hypno of the word of Hypnosis.


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Antifibrinolytic agents and major cardiovascular surgery
General anesthesia and seizures
Commentary Free access | 10.1172/JCI66724
Understanding the TXA seizure connection
Debra A. Schwinn,1 G. Burkhard Mackensen,2 and Emery N. Brown3
1Department of Anesthesiology, Pharmacology, and Biochemistry, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA. 2Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, Washington, USA. 3Department of Brain and Cognitive Sciences, MIT-Harvard Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Address correspondence to: Debra A. Schwinn, Dean, Roy J. and Lucille A. Carver College of Medicine, Professor of Anesthesiology, Pharmacology and Biochemistry, The University of Iowa, 212 CMAB, 451 Newton Road, Iowa City, Iowa 52242-1101, USA. Phone: 319.384.4547; Fax: 319.353.5617; E-mail: debra-schwinn@uiowa.edu.
Find articles by Schwinn, D. in: JCI | PubMed | Google Scholar
Find articles by Mackensen, G. in: JCI | PubMed | Google Scholar
Find articles by Brown, E. in: JCI | PubMed | Google Scholar
Published in Volume 122, Issue 12 on December 3, 2012
J Clin Invest. 2012;122(12):4339–4341. https://doi.org/10.1172/JCI66724.
© 2012 The American Society for Clinical Investigation
Tranexamic acid concentrations associated with human seizures inhibit glycine receptors
Irene Lecker, … , C. David Mazer, Beverley A. Orser
Antifibrinolytic drugs are widely used to reduce blood loss during surgery. One serious adverse effect of these drugs is convulsive seizures; however, the mechanisms underlying such seizures remain poorly understood. The antifibrinolytic drugs tranexamic acid (TXA) and ε-aminocaproic acid (EACA) are structurally similar to the inhibitory neurotransmitter glycine. Since reduced function of glycine receptors causes seizures, we hypothesized that TXA and EACA inhibit the activity of glycine receptors. Here we demonstrate that TXA and EACA are competitive antagonists of glycine receptors in mice. We also showed that the general anesthetic isoflurane, and to a lesser extent propofol, reverses TXA inhibition of glycine receptor–mediated current, suggesting that these drugs could potentially be used to treat TXA-induced seizures. Finally, we measured the concentration of TXA in the cerebrospinal fluid (CSF) of patients undergoing major cardiovascular surgery. Surprisingly, peak TXA concentration in the CSF occurred after termination of drug infusion and in one patient coincided with the onset of seizures. Collectively, these results show that concentrations of TXA equivalent to those measured in the CSF of patients inhibited glycine receptors. Furthermore, isoflurane or propofol may prevent or reverse TXA-induced seizures.
Irene Lecker, Dian-Shi Wang, Alexander D. Romaschin, Mark Peterson, C. David Mazer, Beverley A. Orser
Transexamic acid (TXA) is an antifibrinolytic that has been used successfully to prevent blood loss during major surgery. However, as its usage has increased, there have been growing reports of postsurgical seizure events in cardiac surgery patients. In this issue of the JCI, Lecker et al. explore this connection and suggest that TXA-mediated inhibition of glycine receptors may underlie the effect. This finding prompted the authors to explore the preclinical efficacy of common anesthetics that function by reducing the TXA-mediated inhibition to prevent or modify postsurgical seizures.
Translation from clinical bedside to laboratory bench and back is the holy grail of medicine. In this issue, Lecker et al. (1) undertake just such a translation. In an elegant set of studies, the authors investigate the neuronal mechanisms that underlie seizures occurring as side effects in patients receiving transexamic acid (TXA) to reduce blood loss during major cardiovascular surgery. Given the structural similarity between the antifibrinolytic drug TXA and inhibitory neurotransmitter-gated Cl– channel glycine receptors, the authors tested the hypothesis that TXA inhibits glycine receptor action as a possible mechanism underlying the seizures. After demonstrating that TXA inhibits glycine receptors, they then proposed that anesthetic agents with glycine receptor agonist properties may be uniquely suited to prevent such seizures. The studies presented are of high quality, based on an impressive range of laboratory data and models. However, they may be premature in recommending specific clinical actions to prevent seizures based on the limited clinical data. To place these interesting and provocative translational findings in context, we review use of antifibrinolytics in major cardiovascular surgery; this is followed by a brief overview of mechanisms of general anesthesia recognized to date and how anesthetic agents may play a role in treating seizures generally rather than specifically. We conclude by suggesting how the work of Lecker et al. moves the field forward, and where further work is still needed.
Excessive perioperative bleeding remains a complication of cardiac surgery employing cardiopulmonary bypass, with blood transfusions considered a major contributor to subsequent morbidity and mortality (2). Despite serious efforts to achieve perioperative blood conservation by multimodal approaches (e.g., point-of-care monitoring paired with institution-specific blood transfusion algorithms and applied pharmacologic strategies), cardiac surgery patients continue to receive the vast majority of all perioperative blood transfusions (3). Therefore, antifibrinolytic therapy, because of its proven hemostatic effects, has become routine in this setting. Historically, three main antifibrinolytics have been used in cardiac surgery: lysine analogs ε-aminocaproic acid (EACA) and TXA in patients at low risk for bleeding, and the serine protease inhibitor aprotinin in patients at high risk for perioperative bleeding (such as those undergoing re-operations). However, with the removal of aprotinin from clinical practice following its association with a higher incidence of death and renal dysfunction in the Blood Conservation Using Anti-Fibrinolytics in a Randomized Trial (BART) study, many institutions worldwide have updated their therapeutic protocols (4, 5). The safety concerns surrounding aprotinin use that were raised in the BART study are largely backed by a recent systematic review and network meta-analysis confirming increased risk of mortality and renal morbidity with aprotinin versus TXA and EACA (6). The search for alternatives to aprotinin recently culminated in a phase 2 clinical trial demonstrating the inferiority of the novel protease inhibitor ecallantide in combating blood loss during high-risk cardiac surgery compared with TXA, and enhanced hemostatic efficacy with higher doses of TXA (7). However, as TXA usage has increased, there has been a growing awareness that some patients experience TXA-induced seizures. Occurrence peaks during the early postoperative period (8) in a dose-related manner (9, 10), and seizures are more common in patients with a history of renal dysfunction (11).
General anesthesia is critical for performing most surgical and many non-surgical interventions (12). This state is induced by administering an intravenous hypnotic such as propofol and maintained by a combination of inhaled drugs, hypnotics, opioids, and muscle relaxants. Understanding the mechanism whereby inhaled anesthetics create this drug-induced reversible coma has been a major area of investigation since the first use of ether in the 1840s. Substantial evidence has established that the molecular targets of inhaled anesthetic drugs in the brain and central nervous system are GABAA, NMDA and glycine receptors, two-pore potassium channels, and HCN channels (13). Although immobility is now believed to result from inhaled anesthetics acting mostly at these targets in the spinal cord (14), the mechanisms of unconsciousness, amnesia, and analgesia are less well defined. In contrast, for propofol, which is known to act by enhancing GABAA inhibition, systems neuroscience analyses now provide highly plausible neural circuit details of how its actions at GABAA receptors in the cortex, thalamus, and brainstem can lead to unconsciousness and sedation (15).
Seizures, typically characterized as hypersynchronous neuronal activity due to unbalanced, uncontrolled excitation, arise through multiple mechanisms (16), and establishing the precise cause is often a challenge. Conditions such as fevers, infection, and brain trauma that enhance neural activity can make seizures more likely. One possible mechanism is loss of control in key GABAergic inhibitory circuits (16). The findings in the current study suggest that inactivation of glycine-mediated circuits, which are also inhibitory networks, may be an alternative mechanism for seizure induction. Although propofol and inhaled anesthetics are not first-line therapies for seizures, they are the last-line therapy for status epilepticus, as they place the patient in a drug-induced coma (17). This coma is typically induced and maintained by sustained delivery of sufficient doses of the anesthetic until the seizure activity, monitored by EEG, converts to a desired level of burst suppression. The presumed mechanisms of action are enhanced GABAergic inhibition (18), as well as metabolically induced opening of ATP-dependent potassium channels (19). The seizure activity is arrested, but the mechanism of the therapy may not relate to the mechanism of the seizure. Therefore, it is highly plausible, as suggested by Lecker and colleagues, that propofol or isoflurane could be used to treat seizures associated with TXA, especially since their in vitro findings suggest that these drugs can directly block glycine-mediated activation induced by TXA.
Since TXA binds competitively to GABA type A receptors, it is perhaps no surprise that an association between TXA and postoperative seizures is found (20). However, it is unclear why most episodes of seizures occur during the immediate postoperative hours, a time when levels of intraoperatively administered TXA in the serum and cerebrum should already be declining. One possibility is that TXA induces modifications (neuroplasticity) in these inhibitory circuits that outlast its pharmacological time course. In addition, TXA is known to cross the blood-brain barrier (BBB), especially when BBB integrity is challenged. Thus, the higher incidence of TXA-related seizures in patients undergoing open-heart procedures may relate to disruption of BBB integrity by cerebral emboli, which are known to be much more prevalent during open-heart procedures versus coronary artery bypass grafting (21). This may also explain why Lecker et al. found higher-than-expected TXA concentrations in CSF from a patient undergoing major aortic surgery, where BBB disruption is also common. Lecker et al. also demonstrated that TXA binds to glycine receptors, at least in mice (1). Thus, competitive antagonism of both glycine and GABAA receptors may serve as one plausible explanation for the association between TXA and postoperative seizures (20).
The next fundamental question is whether TXA-induced convulsions are true seizures or, as some researchers and caregivers report, dystonic movements more akin to those seen in strychnine poisoning. This latter possibility is intriguing given that strychnine is also a competitive glycine receptor antagonist (22). Unfortunately EMG and EEG recordings of the events are lacking due to unexpected timing of these incidents, and it is unknown whether patients have residual cognitive defects. Historically, patients who have seizures after cardiac surgery generally have higher incidence of postoperative neurologic complications, defined as stroke and delirium (8), but it is unclear whether these complications also follow TXA-induced seizures, which are generally easily treated.
Lecker et al. examined possible mechanisms to prevent TXA-induced seizures. Their study elegantly demonstrates that TXA inhibition of glycine receptors activated by a low concentration of glycine is reversed by isoflurane at clinically relevant concentrations, as well as to a lesser extent by propofol (1). Most patients receive sedation (such as continuous propofol infusion) until they are extubated postoperatively in the ICU, a process that may initially mask (or prevent) the occurrence of seizures.
In the article in this issue of the JCI, Lecker et al. provide new information on the mechanism underlying TXA-induced seizures, specifically elucidation of competitive inhibition by TXA of CNS-derived inhibitory glycine receptors. They also demonstrate that TXA inhibition of glycine receptors activated by a low concentration of glycine is reversed by isoflurane at clinically relevant concentrations, as well as to a lesser extent by propofol. These findings suggest that risk for TXA-induced seizures may be reduced by modifying (decreasing) TXA exposure by using a lower-dose regimen, or that seizures may be prevented with the use of isoflurane or propofol after surgery. Since early extubation and shorter ICU time after major surgery correlate with better patient outcome, it may not be practical to continue an anesthetized state for very long after surgery. However, anesthetics have multiple targets, and since most of their transmitted effects are inhibitory, it is likely that various combinations of drugs may work to provide the desired anticonvulsant effects. The use of agents that prevent glycine inhibition by TXA, as reported by the authors, certainly is one intriguing possibility.
The authors are funded by grants from NIH to D.A. Schwinn (HL49103) and E.N. Brown (DP1OD003646).
Conflict of interest: Debra A. Schwinn is a consultant for Watson Pharmaceuticals.
Reference information: J Clin Invest. 2012;122(12):4339–4341. doi:10.1172/JCI66724.
See the related article at Tranexamic acid concentrations associated with human seizures inhibit glycine receptors.
Lecker I, Wang D-S, Romaschin AD, Peterson M, Mazer CD, Orser BA. Tranexamic acid concentrations associated with human seizures inhibit glycine receptors. J Clin Invest. 2012;122(12):4654–4666.
View this article via: JCI Google Scholar
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Ferraris VA, et al. Perioperative blood transfusion and blood conservation in cardiac surgery: the Society of Thoracic Surgeons and The Society of Cardiovascular Anesthesiologists clinical practice guideline. Ann Thorac Surg. 2007;83(5 suppl):S27–S86.
Mangano DT, Tudor IC, Dietzel C. The risk associated with aprotinin in cardiac surgery. N Engl J Med. 2006;354(4):353–365.
Fergusson DA, et al. A comparison of aprotinin and lysine analogues in high-risk cardiac surgery. N Engl J Med. 2008;358(22):2319–2331.
Hutton B, Joseph L, Fergusson D, Mazer CD, Shapiro S, Tinmouth A. Risks of harms using antifibrinolytics in cardiac surgery: systematic review and network meta-analysis of randomised and observational studies. Brit Med J. 2012;345:e5798.
Bokesch PM, et al. A phase 2 prospective, randomized, double-blind trial comparing the effects of tranexamic acid with ecallantide on blood loss from high-risk cardiac surgery with cardiopulmonary bypass (CONSERV-2 Trial). J Thorac Cardiovasc Surg. 2012;143(5):1022–1029.
Manji RA, Grocott HP, Leake J, et al. Seizures following cardiac surgery: the impact of tranexamic acid and other risk factors. Can J Anaesth. 2012;59(1):6–13.
Murkin JM, Falter F, Granton J, Young B, Burt C, Chu M. High-dose tranexamic acid is associated with nonischemic clinical seizures in cardiac surgical patients. Anesth Analg. 2010;110(2):350–353.
Kalavrouziotis D, Voisine P, Mohammadi S, Dionne S, Dagenais F. High-dose tranexamic acid is an independent predictor of early seizure after cardiopulmonary bypass. Ann Thorac Surg. 2012;93(1):148–154.
Montes FR, Pardo DF, Carreno M, Arciniegas C, Dennis RJ, Umana JP. Risk factors associated with postoperative seizures in patients undergoing cardiac surgery who received tranexamic acid: a case-control study. Ann Card Anaesth. 2012;15(1):6–12.
Brown EN, Lydic R, Schiff ND. General anesthesia, sleep, and coma. N Engl J Med. 2010;363(27):2638–2650.
Hemmings HC Jr, Akabas MH, Goldstein PA, Trudell JR, Orser BA, Harrison NL. Emerging molecular mechanisms of general anesthetic action. Trends Pharmacol Sci. 2005;26(10):503–510.
Antognini JF, Schwartz K. Exaggerated anesthetic requirements in the preferentially anesthetized brain. Anesthesiology. 1993;79(6):1244–1249.
Brown EN, Purdon PL, Van Dort CJ. General anesthesia and altered states of arousal: a systems neuroscience analysis. Annu Rev Neurosci. 2011;34:601–628.
Schwartzkroin PA. Basic mechanisms of epileptogenesis. In: Wyllie E, ed. The Treatment of Epilepsy. Philadelphia, Pennsylvania, USA: Lea and Febiger;. 1993;:83–98.
Mirsattari SM, Sharpe MD, Young GB. Treatment of refractory status epilepticus with inhalational anesthetic agents isoflurane and desflurane. Arch Neurol. 2004;61(8):1254–1259.
Bai D, Pennefather PS, MacDonald JF, Orser BA. The general anesthetic propofol slows deactivation and desensitization of GABA(A) receptors. J Neurosci. 1999;19(24):10635–10646.
Ching S, Purdon PL, Vijayan S, Kopell NJ, Brown EN. A neurophysiological-metabolic model for burst suppression. Proc Natl Acad Sci U S A. 2012;109(8):3095–3100.
Furtmüller R, et al. Tranexamic acid, a widely used antifibrinolytic agent, causes convulsions by a gamma-aminobutyric acid(A) receptor antagonistic effect. J Pharmacol Exp Ther. 2002;301(1):168–173.
Neville MJ, Butterworth J, James RL, Hammon JW, Stump DA. Similar neurobehavioral outcome after valve or coronary artery operations despite differing carotid emoblic counts. J Thorac Cardiovasc Surg. 2001;121(1):125–136.
Makarovsky I, et al. Strychnine—a killer from the past. Isr Med Assoc J. 2008;10(2):142–145.
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Version 2 (December 3, 2012): No description


'You were meant to be watching him' she said quietly as she passed me, carrying the kettle to the sink.
I put my black boot on the rusting metal lever of the white plastic kitchen bin and held a plate over its whale-like mouth.
'I can't bear to throw this away' I said to her on her return journey, staring at the last piece of bread and butter I would ever prepare for his supper.
'What else are you supposed to do with it? ' She replied, marking the end of the conversation with a forceful flicking on of the switch.
The cheap thin white bread, once perfectly flat, was curled up at the sides, and the thick margarine, already artificially yellow from the outset, was almost orange in parts by now, with an extra film of jelly-like grease starting to form on the surface. It glistened and glowed under the stark tubular light in the kitchen, and seemed to be the only colour I saw on that monochrome day. The dated kitchen was lined with stark white cupboards, with different shades of grey trim on the handles, and smatterings of grey flecks in the formika worktops. Weary mourners leant their grey and black bodies against the pale cupboards, their duty coming to an end.
I wanted to keep that last supper forever, that bread that I used to be embarrassed to buy in the shops, the spread that I warned him about every evening at 9.
I wanted to keep it in a plastic box to look at every day. I wanted to use it as my punishment. I would make myself stare at it every day as a reminder of what I hadn't done.
When they'd come to take his body out on the stretcher I had snuck into the kitchen to make it. I'd covered it in clingfilm and put it in the cupboard. It was the only job I had been asked to do. I had to do it. No matter how late I was.
'It stinks,' she said as she snatched it from me, clingfilm, plate and all, and dropped into the bin. She elbowed me away so that my foot left the lever and the lid snapped shut.
I felt for the spare key in my pocket.
I would come back and get it tomorrow evening at 9.


text:
CCEW publishes new guidance for charity independent examiners
By Christine Scott, Head of Charities and Pensions
The CCEW has published revised Directions and guidance for charity independent examiners, applicable to the examination of English and Welsh charities.
Three new Directions are included and there is a new accompanying checklist to assist examiners comply with the Directions.
The revised Directions and guidance are mandatory for reports on independent examinations which are signed on or after 1 December 2017. Early adoption is encouraged.
The Charity Commission for England and Wales (CCEW) has published revised guidance on how to carry out an independent examination of charity accounts.
Independent examination of charity accounts: Directions and guidance for examiners (CC32) updates the June 2015 edition.
The new guidance includes three new Directions, making 13 directions, which must be followed by independent examiners of CCEW registered charities:
Direction 2
This sets out requirements for examiner independence; examiners must check for any conflicts of interest that may prevent them from carrying out the independent examination.
Direction 2 emphasises that the independent examiner cannot be the charity's bookkeeper. However, the examiner may assist in preparing the accounts with the proviso that: the accounting records have been maintained by another person; the examiner has had no direct involvement in the day-to-day management or administration of the charity; and the trustees review and approve the accounts.
This requires examiners to check that related party transactions in accounts prepared under the Charities SORP (FRS 102) are properly disclosed.
Strictly speaking Direction 7 does not apply to the independent examination of receipts and payments accounts, but if such a charity makes any related party disclosures voluntarily these will need to be reviewed.
The inclusion of Direction 7 reflects CCEW concerns about the risk of unauthorised remuneration being paid to trustees or unauthorised private benefit being received by trustees.
This requires examiners to check whether the trustees have considered the charity's financial circumstances when preparing the accounts. In addition, for true and fair accounts prepared under the Charities SORP (FRS 102), examiners are specifically required to consider whether the trustees have assessed the charity's position as a going concern.
Direction 9 reflects the importance the CCEW places on the financial sustainability of charities. The Direction also highlights the conceptual and practical challenge of arriving at form or words suitable for an independent examiner to apply. The going concern concept is clearly defined in FRS 102 and the Charities SORP (FRS 102) but it is not a concept that applies to receipts and payments accounts and the Direction reflects this.
Expanded guidance
The revised guidance also includes:
A framework for the independent examination of smaller charity group accounts for the first time.
An expanded range of example independent examiner's reports.
Updated material to reflect the revised guidance published in April 2017 by the UK charity regulators for auditors and examiners about reporting matters of material significance to the charity regulators. The revised 'whistleblowing' guidance was issued jointly by the CCEW, OSCR and the CCNI.
Guidance on fund accounting: Appendix 7 largely replicates Module 2 of the Charities SORP (FRS 102).
Smaller charity group accounts
For the purposes of the guidance, smaller charity group accounts, are group accounts prepared on a voluntary basis. Where there is a statutory requirement to prepare group accounts these must also receive an audit rather than an independent examination.
Independent examiner report examples
Appendix 4 of the guidance contains 12 independent examiner report examples which are listed in the table below. The list while comprehensive is not exhaustive and independent examiners must ensure that reports are tailored to the individual circumstances of the charity and comply with reporting requirements set out in the Charities (Reports and Accounts) Regulations 2008.
Unqualified report examples
Unqualified report for a non-company charity preparing true and fair accounts with a gross income of £250,000
Unqualified report for a non-company charity preparing receipts and payments accounts with a gross income of £250,000 or less in the relevant financial year
Unqualified report for a company charity with a gross income exceeding £250,000
Unqualified report with a matter of concern reported due to a one-off lapse in the keeping of accounting records (specifically, tailored for a Charitable Incorporated Organisation preparing receipts and payments accounts)
Qualified report examples
Qualified report, with a matter of concern reported due to a failure to prepare receipts and payments accounts properly (N.B only non-company charities can prepare receipts and payments accounts)
Qualified report, with a matter of concern reported, for a non-company charity with a gross income of £250,000 or less
Qualified report, with a matter of concern reported, for a charitable company with gross income of £250,000 or less
Cross-border charity report examples
Unqualified report for a non-company charity preparing true and fair accounts, which is also registered with OSCR
Unqualified report for a non-company charity preparing receipts and payments accounts, which is also registered with OSCR
Unqualified report for a charitable company, also registered with OSCR
Unqualified report for a non-company charity preparing true and fair accounts with an income of less than £250,000, which is also registered with the CCNI
Smaller group report example
Unqualified report for smaller charity group accounts
Where an independent examiner issues a 'qualified' report, this is considered to be a matter of material significance which gives rise to a separate duty to report to the CCEW and, in the case of cross-border charities, to the Office of the Scottish Charity Regulator (OSCR) or the Charity Commission for Northern Ireland (CCNI).
New checklist
For the first time, the CCEW has published a checklist (CC32a) to accompany the guidance to assist independent examiners comply with the Directions.
The new Directions and guidance are mandatory for reports on independent examinations which are signed and dated on or after 1 December 2017. This is to allow time for examiners to familiarise themselves with the guidance. However, the CCEW is encouraging early adoption.
Image credit: Saranya33 / Shutterstock.com


One of the ventilation stations at a mine in Witbank coalfield, South Africa, was experiencing repeated impeller failures in fans installed by a third party. Howden engineers were invited to investigate and propose a remedy.
One of the mine's main ventilation stations uses three 4.5m centrifugal fans in a trifurcated arrangement, VSD driven, with two fans running and one on standby at any one time. The fans were installed between 2008 and 2010 by a South African supplier and Howden competitor. However, between the time of commissioning and early 2012, seven impeller failures occurred in the new fans. The owners invited Howden Fan Equipment to carry out a preliminary site investigation, and subsequently commissioned us to follow this up with a full surface fan design review.
Vibration analysis of the rotating assemblies.
Finite element analysis of the rotating assemblies.
Hydrological analysis of water table conditions.
These investigations yielded some significant results. Most importantly, mechanical run-down testing demonstrated that the installed fans were running at twice the critical speed of the impeller. This dramatically reduced the expected life of the impeller to as little as a few hours. However, we also found that the scantlings were below Howden specifications, and serious miscalculation at the civil engineering and construction stages meant that the fan bases were built higher than originally designed. At that height, they were not robust enough to absorb the vibrations from the fans, and this contributed to the shortened impeller life. In addition, the ground around the collar had not been properly compacted, allowing the collar to move slightly. Fortunately, a visual inspection of the up-cast shaft showed no damage had yet been caused by the collar movement.
Rather than suggesting complete fan replacement, we replaced the entire rotating assemblies comprising the impeller, shaft, bearings and bearing bases with custom engineered Howden assemblies designed to take all the extraneous factors into account. After rectifying the problems with the fan bases by casting a concrete mass around them to increase stiffness, the new rotating assemblies were retrofitted into the existing casings.
The client was pleased not only to have the problems identified and solved, but to have the solution managed in the most cost effective and least time consuming way possible.


That's right, nothing to do with alien pod people–and certainly not the third remake with Kidman and Craig…no, we're going back to Robert Louis Stevenson's story, adapted by Val Lewton and directed by Robert Wise. I decided to go with this film after we wrapped up last year at this time with The Dark Eyes of London with Bela Lugosi. (Previously we were on a Tod Browning kick.) But Lugosi leads us to this film, starring Boris Karloff.
And after seeing Corridors of Blood, I think about that every time I see Karloff anywhere near a medical scene. That one's worth checking out as well, though less in our genres of choice here.
The movie is available as a double feature DVD, but if you have a little bit more coin, I recommend The Val Lewton Horror Collection, because it comes with scads of classic films.
Next postWin Blood Ties: Season 2 on DVD!


text:
Anna Stansbury Wins Upjohn Institute Dissertation Award
Former Stone PhD Scholar Anna Stansbury, current Assistant Professor of Work and Organization Studies at MIT Sloan School of Management, has won the 2021 Dissertation Award from the W.E. Upjohn Institute for Employment Research. Her dissertation, "Essays on Power in Labor Markets," examined three aspects of power and institutions in the U.S. and U.K. labor markets: 1) the wage effects of employer concentration and worker outside options in the United States, 2) the decline of worker power and its macroeconomic implications in the United States, and 3) minimum wage compliance and enforcement in the United States and United Kingdom.
See also: Alumni, Awards


text:
Study Shows Promising Results for Patients with Advanced Lung Cancer
By Robert Dillard - Last Updated: February 24, 2020
The findings of a Yale Cancer Center study shows that even a tiny amount of a biomarker known as PD-L1 (programmed death-ligand1) can predict a long-term survival benefit from using pembrolizumab (Keytruda), one of the first checkpoint inhibitors to be developed and used in advanced lung cancer treatment. The findings were published the Journal of Clinical Oncology.
"The response that we have seen from pembrolizumab, in a subset of patients years after treatment ended, is remarkable, especially since their chemotherapy had initially failed," said Roy S. Herbst, M.D., Ph.D., chief of Medical Oncology at Yale Cancer Center and Smilow Cancer Hospital and Associate Cancer Center Director for Translational Research at Yale Cancer Center in a press release.
In a phase III KEYNOTE-010 clinical trial, which was conducted in 202 academic medical centers in 24 countries, researchers compared use of pembrolizumab in 690 patients to treatment of docetaxel chemotherapy in 343 patients. The results showed that in 79 of 690 patients who received two years of pembrolizumab, the overall survival rate was about 99% one year after discontinuing treatment. Overall, survival in this group three years after the two-year treatment period ranged from 23% to 35%, depending on how much of the PD-L1 biomarker their cancer expressed, compared with 11% to 13% in patients receiving chemotherapy.
https://twitter.com/physorg_health/status/1230598003360227336
"Before we had pembrolizumab, survival from advanced lung cancer was measured in months, not years," Herbst said. "It is too soon to say that pembrolizumab is a potential cure for a substantial number of patients whose tumors express PD-L1, and we know that it doesn't work for all patients, but, the agent remains very, very promising. The majority of patients who completed two years of treatment remain in remission and those who had recurrence could be retreated with pembrolizumab at the time of progression and still achieve disease control."
https://twitter.com/bioengineerorg/status/1230607997128368150
https://twitter.com/sciencecodex/status/1230656263719026688
Nurse-Led Smoking Cessation Intervention Could Aid in Screening of High-Risk Lung Cancer
Leah LawrenceLung Cancer | January 26, 2023
A combination approach that includes lung cancer screening was effective in older patients.
AACR, ASCO Release Statement on Use of Electronic Nicotine Delivery Systems
Is vaping safer than smoking? A new joint statement from AACR and ASCO points to alarming evidence for carcenogenesis.
Involvement of Palliative Care Team Improved Advanced Care Planning for Veterans With Cancer
Leah LawrenceNews | January 18, 2023
A study attempted to explore the role of palliative care in facilitating advance directive discussions among veterans.


text:
Q: How to check if any tuples exists for a list of strings I'm trying to check how many tuples from a list of tuples exists in another list of string and I want all of the tuples associated to the particular string as well.
Example:
A = [["is", "a"],["is", "going"],["to", "the"]]

B = ["This is a bat", "Adam is going to the school"]

I want the result in terms of which tuple exist in which string.
DESIRED OUTPUT
["is", "a"] exists in "This is a bat"

["is", "going"] and ["to", "the"] exists in "Adam is going to the school"

I have tried the below code, but it only gives all of the tuples which exists in list B
A = [["is", "a"],["is", "going"],["to", "the"]]
B = ["This is a bat", "Adam is going to the school"]
matching = [s for s in B if any(x in s for x in A)]

EDIT:
Another approach tried
A = [["is", "a"],["is", "going"],["to", "the"]]
B = ["This is a bat", "Adam is going to the school"]
    for i in range(len(B)):
        flag = False
        keywords = ""
        for a in A:
            if a[0]+" "+a[1] in B[i]:
                if(keywords == ""):
                    keywords = a[0]+" "+a[1]
                else:
                    keywords = keywords + ", " + a[0]+" "+a[1]
        print(keywords)

This approach works fine, can it be more optimized ?

A: import re

A = [["is", "a"], ["is", "going"], ["to", "the"]]
joined_A = [" ".join(a) for a in A]

B = ["This is...a bat!", "Adam is going to the school"]

for s in B:
    print(s)
    normalised = " ".join(re.findall(r"\b\w+\b", s))

    for a, joined in zip(A, joined_A):
        if joined in normalised:
            print(a)

Output:
This is...a bat!
['is', 'a']
Adam is going to the school
['is', 'going']
['to', 'the']

A: You could use ' '.join() to merge the list from A, then see if it is in the string in B:
from collections import defaultdict

matches = defaultdict(list)
for match_string in A:
    for string in B:
        if ' '.join(match_string) in string:
            matches[string].append(match_string)

Output:
{
    'Adam is going to the school': [['is', 'going'], ['to', 'the']],
    'This is a bat': [['is', 'a']]
}

A: Code:
from re import search

A = [["is", "a"], ["is", "going"], ["to", "the"]]
B = ["This is a bat", "Adam is going to the school"]

p_A = ["\\s".join(i) for i in A]
matches = [(s, [A[i] for i, e in enumerate(p_A) if search(e, s)]) for s in B]
for string, patterns in matches:
    print("%s exists in \"%s\"" % (" and ".join("[%s]" % ", ".join("\"%s\"" % s for s in p) for p in patterns), string))

Output:
["is", "a"] exists in "This is a bat"
["is", "going"] and ["to", "the"] exists in "Adam is going to the school"

A: from sklearn.feature_extraction.text import CountVectorizer
from io import StringIO

A = [["is", "a"], ["is", "going"], ["to", "the"]]
joined_A = [" ".join(a) for a in A]

B = ["This is a bat", "Adam is going to the school"]

def tokenizer(text):
    return text.split()

vec = CountVectorizer(ngram_range = (1,2), tokenizer = tokenizer)

for string in B:
    vec.fit_transform(StringIO(string))
    wordlist = []
    for word, prev in zip(joined_A, A):
        if word in vec.get_feature_names():
            wordlist.append(prev)
    print(f"{wordlist} exists in {string}")

#Output
[['is', 'a']] exists in This is a bat
[['is', 'going'], ['to', 'the']] exists in Adam is going to the school

I'm using sklearns CountVectorizer to create lists of all words in the string, then check whether our words are there or not.
I used @Alex Hall joining of words in A since you wanted them to be considered a pair.
We normally wouldn't have to define the function tokenizer, but since sklearns CountVectorizer automatically removes some words like "a" even with stop words turned off we needed to define it here.
ngram_range in our count vectorizer changes how many consecutive words are considered unique. If we left it at 1, it would only be 1 word. 1,2 makes it a most 2 words. You will have to increase the number 2 to be as large as your longest list in A. If all your combos of A are 2 words then you will want to set it to (2,2) to increase speed.
Finally we just loop around the strings. We use get_feature_names to pull all the different strings from B, then check if A is there or not. Then finally print the answer.

redpajama_set_name: RedPajamaStackExchange


« Pet Peeve: "All Stem Cell Research is the Same"
debate. It was originally published in The Catholic Anchor, a student-run newspaper/magazine sponsored by the Ryan Catholic Newman Center.
with isolated cells in a culture dish and not inside a living organism.
animals may get prime coverage at the New York Times.
straight on some key issues.
oppose ESCR, you therefore oppose all stem cell research.
just means that you think that it violates medical and scientific ethics.
can. Therefore, we still need ESCR.
from whatever organ or tissue that you are trying to treat.
even harmful, to a patient.
discoveries are just around the corner.
while the ESCR activists just deliver promises.
to articles on some of these advances.
arguments that may leave out people of different faiths.
today. However, I should point out prominent pro-lifer Nat Hentoff. Mr.
from conception till natural death.
long-term promises of a medical revolution.
🙂 And I'm thankful for that assistance, too!
FYI, this was originally published in the March edition of the Catholic Anchor (a student-run publication at the Newman Center). Funky had it adapted for his blog to help clarify issues with stem cell research.
Hey guys – remember me? just wanted to add that if anyone knows any pregnant ladies, there are umbilical cord blood donation organizations whose services are *FREE*, and you get a nice little baby bib that says "world's cutest cord blood donor." my son wears his all the time. It's a nice, subtle, non-combative way to support alternative stem cell research. 🙂 email me for more info!


text:
Township 7 is a township in Rooks County, Kansas, United States. Damar is the largest population center in Township 7.

History
Rooks County was established with four townships: Bow Creek, Lowell, Paradise and Stockton. That number increased to seven by 1878 and twenty three in 1925. The twenty three townships were in place until 1971 when the number was reduced to the current twelve townships.

Township 7 was formed by renaming Richland Township in 1971. While other Rooks County townships were combined pursuant to Kansas Statute 80-1110, Richland was just renamed using the new naming standard.

The South Fork Solomon River traverses the township.

Richland Township
Richland Township was formed in approximately 1880 from part of Stockton Township.

References

Townships in Rooks County, Kansas
Townships in Kansas

redpajama_set_name: RedPajamaWikipedia


Does your dissertation, thesis, or academic article need revision? Are you looking for someone to edit your novel or memoir? Are you trying to write a grant proposal for an amazing project but don't know where to begin?
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For a full resume and to find out more about my background, feel free to visit my LinkedIn page.


text:
Sops galore in Trinamool election manifesto for Meghalaya
The party's promises range from laptops for students, monthly allowances for the jobless and the creation of 3 lakh jobs to a sports university
January 24, 2023 08:54 pm | Updated January 26, 2023 10:18 am IST - GUWAHATI
TMC leader Abhishek Banerjee. File | Photo Credit: PTI
From farm to university, the election manifesto of the Trinamool Congress for Meghalaya has declared a range of promises.
The manifesto, released by the party's national general secretary Abhishek Banerjee in State capital Shillong on January 24, 2023, contains 10 pledges.
These include the generation of 3 lakh jobs over five years, a monthly allowance of ₹1,000 to every unemployed youth, 1 lakh laptops to higher secondary and college-going students, an annual financial assistance of ₹10,000 to farmers, direct benefit transfers of ₹1,200 annually to families of all government school-going children and a sports university.
The Trinamool promised the introduction of a private member Bill in Parliament for the immediate recognition of Khasi and Garo languages through their inclusion in the Eighth Schedule of the Constitution. It also promised to revoke the boundary deal on March 29, 2022, between Meghalaya and Assam to settle disputes in six of the 12 sectors along their border.
Underlining the contribution of tourism to the State's economy, the Trinamool said all individuals engaged in this sector would be identified and their services formalised through government-registered job cards so they get a monthly honorarium of ₹2,500 each.
The party promised to set up medical colleges, and maternal and child care centres in every block to provide efficient prenatal and postnatal services, bridge the shortage of specialists, staff and equipment at all primary health centres and community health centres and facilitate piped drinking water to all households.
Meghalaya has 6,459 villages and the Trinamool committed to connecting all of them with black-topped motorable roads and upgrading the major arterial roads to all-weather roads. Through "Mission Sports", the party will identify, train and promote talent at the block level and set up a state-of-the-art multi-purpose stadium in all districts, the manifesto said.
The other promises include the setting up of a Meghalaya Music Promotion Board to promote the State's musicians through training and assistance with the vision of taking local music to the global stage and establishing a cultural tourism circuit through the identification and the promotion of cultural and ecological hotspots in every district.
"A holistic Village Administration Bill will be introduced in consultation with [three] autonomous district councils and traditional headmen to uphold and protect the traditional institutions," the manifesto reads.
The Trinamool also promised effective and immediate implementation of the Meghalaya Residents Safety and Security Act (MRSSA) of 2016 to ensure a comprehensive registry of all legal tenants. If voted to power, the party will also set up an expert committee to assess the current situation in consultation with all stakeholders and organisations regarding the introduction of the Inner-Line Permit (ILP), and decide the way forward.
Pressure groups in Meghalaya believe the MRSSA and the ILP based on a British-era regulation will help prevent the influx of "illegal migrants".
Meghalaya / Assembly Elections


text:
Q: Spanning a group in terms of traceless tensors In page 7 of the Physics paper Decomposition of non-local light-cone operators
into harmonic operators of definite twist , it is said that

However, for O(N,$\mathbb{C}$) and SO(N, $\mathbb{C}$) these representations, in general,
are not irreducible. The reason is that taking the trace of a tensor commutes with
the orthogonal transformations. Therefore, by Schur's Lemma, irreducible subspaces of
SO(N, $\mathbb{C}$) are spanned by traceless tensors having definite symmetry class.

I don't understand how Schur's lemma, that basically states that an operator $A$ that commutes with the group operation is either $0$ or the identity, can lead to claim that traceless tensors span SO(N, $\mathbb{C}$). I know that traces are invariant under the action of said group, so in principle you would have both traces as irreps and traceless tensors.
My second question is that if those traceless tensors can be decomposed in irreps or not.


text:
HUNGER 22: The Beauty Issue
Over the past decade, photographer Rankin and beauty editor Marco Antonio have created some of the most eye-catching beauty images that the world has ever seen. Their creative prowess is perfectly demonstrated in their collaborative book, Marco x Rankin, which was released in 2019. But the union didn't stop there...
Their latest collaborative endeavour is a special edition of HUNGER where they pit glam and natural (two of beauty's most iconic trends) against one another across 160+ pages of original shoots. To help with the project, the duo called upon the likes of Byredo, Dior Beauty, Nars, Shiseido and Gucci Beauty to assist them in creating iconic looks on an array of models and talent.
The first cover reveal from the issue is the brilliant Francesca Hayward. The principal dancer for the Royal Ballet and aspiring actress shows the elegance and grace in natural beauty. In her interview, she discusses managing beauty standards in the world of dance, and how she handled the harsh critique around her debut film, Cats!
Second cover, we catch up with Anya Chalotra as she prepares for S2 of The Witcher. In her interview, she discusses reconnecting with her inner child and submerging herself into the world of fantasy
Supermodel Leomie Anderson proves that the best things do come in small packages as she unveils what's inside the Dior Beauty advent calendar.
About Last Night… NARS turns the heat up to another level with looks for the most decadent of nights. It is party season after all
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"Kat" Gates-Skipper Inducted into Florida Veterans' Hall of Fame
Kat Gates-Skipper
Kathryn "Kat" Gates-Skipper from Lake Wales, along with 16 fellow Floridians, was inducted Monday, March 9 into The Florida Veterans' Hall of Fame at the Capitol Building in Tallahassee.
The Florida Veterans' Foundation joined with the Florida Department of Veterans Affairs to recognize these Military Veterans that have made a significant contribution to the State of Florida.
The Medal Ceremony began at 10:30 a.m. in the Cabinet Meeting room. The medal was presented by CFO Jimmy Patronis. FDVA Executive Director Danny Burgess congratulated inductees on behalf of the Florida Department of Veterans' Affairs for their selfless service and sacrifice.
After the Medal Ceremony, inductees, guests and family moved to the Plaza Level of the Capitol. After a countdown, the attendees were treated to the unveiling of the Class of 2019 names that were added to the plaque hanging on the Veterans' Hall of Fame Wall.
A reception, sponsored by the Florida Veterans' Foundation, was held on the 22nd floor of the Capitol building. The inductees received additional recognition in the form of a Florida Veterans' Hall of Fame framed Certificate signed by Florida Governor Ron DeSantis, Danny Burgess (FDVA Exec Dir), and Ray Quinn (Chairman of Florida Veterans' Hall of Fame); challenge coins from the Florida Veterans' Foundation & Florida Veterans' Hall of Fame, membership into the Florida Veterans' Hall of Fame Society, Inc. along with a patch and pin to wear.
Gates-Skippert also received a personal letter of appreciation signed by U.S. Sen. Rick Scott.She was accompanied by her Army usband, Charles Skipper, and she had several friends and state Representatives in the audience, as well.
When asked what being in the Florida Veterans Hall of Fame meant to her, she said: "My Husband is my soulmate, my rock, and the reason I do what I do. This medal and induction into the Florida Veterans' Hall of Fame, is the icing on the cake and means a lot to me in so many ways. Recognition from my peers is humbling. I'm just a veteran trying to help other veterans. Most importantly, it's a legacy I leave behind for my children and grandchildren. I hope that I have taught them it isn't as much the material things that matter in life but rather, the love and respect, what you do for people and your country, that matter most of all."
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London will also be the site of preliminary peace talks beginning this week. After more than nine months of fighting between Nigeria and the secessionist government of Biafra, the two sides agreed last week to meet there and try to pick a site for full-scale peace negotiations, probably somewhere in Africa. Any talks face formidable difficulties: Nigeria insists that Biafra rejoin the country and be split up into three states; Biafra demands that it retain some form of sovereignty in order to protect its 8,500,000 Ibo tribesmen.
One good reason for talking now is that the war has reached an impasse. Nigeria's superbly equipped army of 85,000 men has captured all but one of Biafra's major cities, including the capital of Enugu, squeezing the rebel army of some 35,000 into an interior area only a third as large as the 29,000 sq. mi. that it originally held. Even so, because they fear genocide at the hands of the other Nigerian tribes if they are defeated, the Ibo stubbornly fight on. They have managed to hold Port Harcourt, Biafra's main port, and have fought a hard rear-guard action. Frustrated by its failure to win a decisive victory, the federal government has tried to break the Biafrans by stepping up its bombing of their countryside, using Russian-supplied planes and bombs and Egyptian pilots.
Without prelude, the rapid approach of a loud, metallic whine overhead transformed normal activity in the township of Umuahia, which now serves as the rebels' headquarters, into frightened cries and panicked running about. A few seconds later, a single low-flying jet plane cut a straight line across the town, releasing as it went six pairs of rockets. Two plowed caverns into the grass huts outside the Red Cross headquarters at Saint Stephen's School, where schoolgirl volunteers sat outside preparing garri for the evening meal.
The teen-agers were killed instantly. After the raid, as I walked through the heart of Umuahia's residential quarter, a Ministry of Works dump truck had begun plying the streets to collect other victims.
The scene I witnessed at Umuahia's Queen Elizabeth Hospital following the air raid was repeated in nearly every Biafran town I visited. Under tall shade trees outside an already filled mortuary lay a score of corpses, including pregnant women and months-old babies, charred, disfigured and mangled. Amid the tearful cries of keening women, workers carried into the morgue mashed human fragments piled on stretchers, and limbs and torsos balanced on shovels. The next morning, clutching handkerchiefs over nose and mouth against the stench and carrying freshly sawed unpainted wood coffins, the families lined up patiently under the trees to bear away their dead for burial.
Though Nigerian Strongman Major General Yakubu Gowon insists that only military objectives are hit, the raids against civilians were, in fact, recently intensified to two-a-day strikes on all Biafran towns. During the six days I spent in Biafra, civilian bombing casualties totaled 300 dead by actual body count. I saw jets repeatedly release payloads on populated townships where not a single military installation was within range.
Nigerian jets returning to their bases have even doubled back to strafe ci vilian crowds gathered at railway crossings, in village marketplaces and in a churchyard after morning services. Nigeria's Egyptian pilots have so often bombed and strafed Biafran hospitals—whose roofs are often clearly marked with large red crosses—that Ibo mothers in some areas risk death for their seriously ill children rather than take them to such prime target areas.
Since the air war can only be waged with outside aid, Biafra's Oxford-educated leader, Lieut. Colonel Odumegwu Ojukwu, 34, is understandably outraged at the Russians and Egyptians. When I met Ojukwu on the evening of the Umuahia air raid in his closely guarded stucco house atop a hill outside town, he spoke of the "hot and cold flashes that go through my mind" when he sees the air raid victims. "Viewing their mangled remains on a mortuary slab," he said, "I feel anger with those who made devastating weapons available to primitive men. I even find myself wondering whether there is a God, and what has happened to the conscience of the world."


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TSLS 0004 - The secret to writing well is feeling well.
Do you know one of the most common ways writers mess up their creative mojo?
We spend way too much time daydreaming about how good we'll feel after we finish writing our book.
You will feel amazing once you finish your book or your latest project, for sure, but being laser-focused on the future just drains your happiness away from the present. The more you think about how much you want to become a best-selling author, the further and further away it feels when you're trying to get all the smaller tasks done each day.
That's when most writers get frustrated and overwhelmed. When our worth and our idea of success become so connected that the stress of trying to achieve what you want for yourself causes more harm to our wellbeing than good.
Feeling well is the secret to writing well.
And by "feel well", what I mean is being in a healthy relationship with yourself.
Do you remember when you loved to write before you started seeking outside validation? Back when it was for the fun of it and not because you needed to impress other people? There's a person inside of you who still loves to do that (your #wholewriter). And conversely, by not worrying about what the outcome of your work might be and by simply enjoying what you create gives your work the best chance of being authentic and successful. If you can transform this mindset, you will transform everything else in your life.
1) Writing is a long, long game.
It's a game that requires energy, strength and stamina. You will experience your fair share (and sometimes MORE than your fair share) of rejection along your journey, from editors, to agents, to publishers. You will also experience a bunch of people known as "haters" in your writing career, and these range from strangers to ex-friends, to *gasp!* family members. The last thing you need on top of all that is YOU telling yourself that your work is terrible.
When you have inner strength, high self esteem and that super strong belief in your own worth, it's harder for people and events to take your off your path. When you love yourself, you'll know that you can only control the future by controlling your daily actions and honouring yourself enough to set yourself up for success by doing the work and not worrying about what others think.
3) When you feel good, you stop needing external validation.
I know as a writer you do a ridiculous amount of work when putting something creative together and trying to make your dreams happen, but because it is a solitary profession, there will be times where no one else will be around to see it.
There might not be anyone to acknowledge you in your proudest moments, so not only do you have to learn how to work without that kind of praise from other people, but you have to learn how to cheer yourself on in those proud moments. I hope you'll find that making yourself proud can be just as fulfilling as when you finally put that work out into the world.
4) You will see a lot of people around you succeed, but you can't let that phase you.
We all know a Mina Schwartz who has unintentionally makes us feel bad about our own lives and accomplishments at one point or other in our lives. But when you feel good about what you're doing, you won't have the time or energy to worry about her, or to compare yourself, or to put your own work down no matter how slow or hard the journey may be. It's yours and only yours.
5) You will see a lot of people around you fail, but you can't let that phase you.
Oh, boy. This one hits me hard. It's a terrifying phenomenon that happens if you've been a writer for long enough: some of the people around you will give up. Quit. Change direction. All leaving you feeling disorientated because the ones you once looked up to and went to for support and advice are dropping like flies, talking about how they find Instagram modelling much better. Keep that faith in yourself and your projects and stay on the path if it feels good - don't fold due to other people's fears.
6) When you feel well, you'll stay true to your purpose.
There are a million things that you could do that are easier than writing. Writing takes work. And so there will be a parade of tempting opportunities that will come your way that seem like the quicker, easier roads to success, but ultimately pull you away from your destiny. Only your values and inner strength will be able to save you from the barrage of lesser activities designed to steal away time from your ultimate purpose.
7) You deserve to feel good about the work you do.
How many people, instead of focusing on how glorious it is to create in this world, and what an incredible responsibility it is to be a messenger and story crafter on this earth today, are bogged down by stresses and insecurities - that not only are they imposing on themselves, but that society is imposing on them, too?
If you ever feel you're doing this to yourself, take a step back and remember why you started in the first place - because you didn't start writing to make yourself unhappy. You started writing to make something happen for yourself and for the world.
If you can hold on to that, no matter how long it takes, you will.
Do you know that feeling well is the secret to writing well? Let me know in the comments section below!