By sending your Soul Core to the Trash, stack this card from your hand onto your target spirit.
[LV1][LV2] (When Advents) Ignoring the "BP +" of Braves, destroy every opposing Spirit/Ultimate with 10000 BP or less. Effects of Spirits/Ultimates destroyed by this effect do not activate.
[LV2] Flash - Consecutive Dominance (When Attacks) By discarding three of this Spirit's Red pre-advent cards, when this turn ends, (Your Turn) occurs one more time.
The Ultimate Terra Dragon and the Red X-Rare of BS41, The DinosaurRuler Dinobrizer(Dinobrizer for short), descend upon us! This card has a cost of 8 with 4 red reduction, and 4 cost is still a lot in this current meta. However, it has the ability Advent, which, with the Soul Core, you can advent for free during the Flash Step. At Level 1, it has 8000 BP, and at level 2, it has 16000 BP, which in this current meta, simply isn't a lot. However, for it's advent cost, the BP is fine.
The advent condition deserves a mention. Right now, for the Terra Dragon Cards that are in the advent saga, a lot of the advent ones have a cost of 6, while a lot of the terra's without advent have a cost of 3. This means that you can combo 3-6-8 in between turns.
There are 2 main effects for Dinobrizer: It's When Advents effect and it's Flash-When Attacks Effect. Both effects obviously have their own merit.
It's When Advents effect is "Ignoring the "BP +" of Braves, destroy every opposing Spirit/Ultimate with 10000 BP or less. Effects of Spirits/Ultimates destroyed by this effect do not activate." Though 10000 BP or less is quite low for the meta, if your opponent is using a lot of low cost spirits then this would be a good board clear, though cards like The SengokuCommander Siegfried-Kai can probably do a better job. However, the merit of using this effect is that, "When Destroyed" effects of spirits won't activate. That means, the annoying effect of The EarthSeraph Ramdiel or Godseeker-Negasbok can't be activated, with Ramdiel being sent to trash and Negasbok not having a chance to search for Artemis again. That being said, this will still only see play within Terra Dragon, but it's still a nice effect regardless to have for both offence and defence.
It's Second effect is the main reason why this card will see play, and is also completely unique to Dinobrizer. It states "By discarding three of this Spirit's Red pre-advent cards, when this turn ends, (Your Turn) occurs one more time." This effect probably reminds you of cards like The ConvictionDownfallSword Judgement-Dragon-Sword or The ConvictionDownfallDragon Judgment-Dragonis . However, both those effects are one turn only, when Dinobrizer's effect can be repeated as long as you have the cards to do so. However, since this is a Flash Timing effect, you are still prone to bouncing magic, so make sure you are ready before using it.
Terra Dragon in the Advent Era have a lot of cards which focus on getting more and more pre-advent cards so that Dinobrizer can work it's magic. Dinobrizer will probably only work in these kinds of decks which are dedicated to adding pre-advent cards, so it can use it's second effect quite often. Terra Dragon hasn't been meta due to it's still slow pace, but if you are able to pull this combo off, momentum could vastly change in your favour.
There are 2 ways of getting Pre-Advent cards under Dinobrizer right now. One is from the Trash, and the other from the Hand.
Firstly, is the effect from the Trash. This mainly uses the Terra Dragon Reload Brave, The DinosaurGun DinolocGun to get cards from the trash onto Dinobrizer. DinolocGun's effect is also a Flash effect, which means that you can activate the effect on the turn that you reload brave it to Dinobrizer. In order to get cards in the trash, the nexus Horned Dragon Mountain can be used for it's first effect, to discard cards from your hand into the trash, and if you don't need to dump cards in the trash, you can instead choose to dump Dyna Power , which comes back to you hand anyway so the nexus effect becomes no condition. There is also the merit of returning cards that were discarded by Dinobrizer's own ability, so that you can charge him up faster.
The second way to get pre-advent cards is from the hand. Almost all the advent-era Terra Dragon cards have some sort of way to get pre-advent cards, so I'll just name the notable few. First is the aforementioned Horned Dragon Mountain, which can add pre-advent cards to a spirit with advent when you decrease the life. Another is The DinosaurAlliance Acrocanthorex , which allows you to add pre-advent cards to use it's quite useful "When Advents" effect. The Burst The DinosaurAlliance ThunderBladeElectrosaurus can be a quick way to get a cost 6 spirit out for Dinobrizer to use, and also has a added bonus of adding another pre-advent card. The last mention is the magic Jurassic Spear , which let's you destroy an opposing spirit with two symbols or more, and add 2 pre-advent cards to this spirit(You can add the pre-advent cards even if you don't destroy a spirit). With a meta filled with plenty of cards that have two symbols or more, for example The SupernovaDragon Siegwurm-Nova or spirits boosted by Artemis's Grand Field, Jurassic Spear can put in a lot of work in destroying and adding pre-advent cards.
Though we have all that, there still needs to be a way to get the card out. The Red Drawing card July Draw can help you draw through your deck, and cards like The DinosaurAlliance Armorhorn Dreadlosaurus will let you draw cards depending how many pre-advent cards it has(which shouldn't be much of a worry), and the card The DinosaurAlliance Stegoral can be used so that you can advent twice in your turn, in order to get Dinobrizer out quicker. A Honourable mention is the The Dark Galaxy of Dust , which although is a cost 5, leaves your spirits refreshed and ready to defend opponent's attacks.
The best way to counter Dinobrizer is using the fact that defender can flash first, and bouncing it's pre-advent cards with cards like Triple Stab or Diamond Wall . You can also choose to deplete it's cores so it doesn't have any core to be at level 2 so it can't activate Consecutive Dominance, and then destroy it with The WarOgre Murciela . Another way is to destroy it, but since a lot of cards have their limit at 15000BP(like The SengokuCommander Siegfried-Kai ) , the 16000BP Dinobrizer will still be unharmed by a lot of spirits.
This spirit has a really unique effect which can be repeatedly used, as long as you have the pre-advent cards on it, and it's first effect is also useful in both attack and defence. It's 16000 BP, though somewhat low, put's it out of range of many board nukes.
It's really easy to bounce and deplete, and it requires quite a bit of setup. The Former can be fixed with cards like Illusion Demon-God , but that would make the setup harder since you do need a lot of Terra Dragon spirits to activate Dinobrizer's Dominance.
The artwork clearly symbolises some sort of Dinosaur King, which brings out the intensity that the card can bring. The name of the second effect, "Consecutive Dominance", can also be related here, since the image projects some sort of power and it's that kind of power which let's it continuously dominate.
This card will get a 6-7, since it requires specific setup and the right cards, but the effect is too unique and the deck is still certainly viable.


text:
Els onquidoridoïdeus (Onchidoridoidea) són una superfamília de mol·luscs gastròpodes nudibranquis marins.

Famílies
Les famílies dins de la superfamília Onchidoridoidea es classifiquen segons el llibre Taxonomy of the Gastropoda (Bouchet & Rocroi, 2005) i són les següents:

 Onchidorididae Gray, 1827
 Akiodorididae Millen & Martynov 2005
 Goniodorididae H. Adams & A. Adams, 1854

Sinònims de famílies:
 Corambidae Bergh, 1871 - fusionada amb Onchidorididae

Referències

Nudibranquis

redpajama_set_name: RedPajamaWikipedia


Hello Friends and Followers of Holiday House Boutique! We are now accepting application for our 2018 Spring Holiday House Boutique. The dates are Thursday, March 15th - Saturday, March 17th, 2018. If you or anyone you know is interested in participating with us, please email us at: holidayhouseidaho@gmail.com for an application. It's going to be a fantastic show!!
We're giving away $100 in Boutique Bucks!
1. Go to @holidayhouseboutique and do the Instagram Scavenger Hunt. The first person to email all of the correct answers to holidayhouseidaho@gmail.com wins $25 in Boutique Bucks.
2. Go to @holidayhouseboutique and do the Instagram Scavenger Hunt. An additional $25 in Boutique Bucks will be awarded to one winner picked from the remaining entries.
3. Go to @hellomeridian and enter the Holiday House Boutique Giveway. She will choose one lucky winner to receive $25 on Boutique Bucks.
4. Go to Holiday House Boutique on Facebook and share the Spring Event on your personal or business page. One entry for each. One lucky winner will receive $25 in Boutique Bucks.
We have several young entrepreneurs who are so excited to show off what they have been working on. Come support these and many other of our favorite kid vendors and see the sweet things that they are saving for. Some of our kid vendors just came home from a trip to Disneyland which they helped pay for with their boutique money. The Holiday House Boutique opens this Thursday at 9 am! Get there early to secure the best selection!
Happy April Fool's! We hope today is spontaneous and fun-filled. These cute characters should inspire your lighter side. We just love their detail and story!
Doozerbug is a world of whimsical wild beasts, magical mermaids, helpful tooth monsters, dainty dinosaurs, and charming farm animals. Visit us and you can discover a child's dream feast of fun felt food perfect for serving plush playmates and maybe share a smile with a quirky creature who just wants to be held. Jenny hand makes and carefully stuffs each item in the hopes that they will be found and loved by a forever friend.


Expert Training Group is a subsidiary of ExperienceCo, an adventure-based tourism company with the vision of becoming the largest and most respected adventure tourism company in the world. ExperienceCo offers adventure experiences in tandem skydiving, hot air ballooning, white water rafting, canyoning, sea kayaking, reef trip and much more to come.
Expert Training Group offers quality, nationally accredited courses designed to assist learners to gain qualifications and specialised skill sets to enhance employment opportunities and provide further education pathways. ETG has built a professional team of trainers who are not only qualified to the standards of the Australian Quality Framework (AQF) but are current specialists in the training they provide.
All training programs have been designed, developed and tailor made to address specific organisational skills gaps or staff development needs. Together with the preferred trainer, ETG will consult with you before and after training delivery to ensure expectations are met and desired outcomes are achieved. ETG also provides flexible online delivery options for several identified units.


text:
Q: mpi_gather, 2d dynamic array in c, exited on signal 6 (aborted) After searching and searching finally I have function which allocate memory for nD array like vector or linear.
Function is:
int malloc2dint(int ***array, int n, int m)
{
    /* allocate the n*m contiguous items */
    int *p = (int *)malloc(n*m*sizeof(int));
    if (!p) return -1;

    /* allocate the row pointers into the memory */
    (*array) = (int **)malloc(n*sizeof(int*));
    if (!(*array))
    {
        free(p);
        return -1;
    }

    /* set up the pointers into the contiguous memory */
    int i;
    for (i=0; i<n; i++)
        (*array)[i] = &(p[i*m]);

    return 0;
}

By using this method I can broadcast and also scatter 2d dynamic allocated array correctly but problem in MPI_Gather still exist.
main function is:
int length = atoi(argv[1]);
int rank, size, from, to, i, j, k, **first_array, **second_array, **result_array;

MPI_Init (&argc, &argv);
MPI_Comm_rank(MPI_COMM_WORLD, &rank);
MPI_Comm_size(MPI_COMM_WORLD, &size);

//2D dynamic memory allocation
malloc2dint(&first_array, length, length);
malloc2dint(&second_array, length, length);
malloc2dint(&result_array, length, length);

//Related boundary to each task
from = rank * length/size;
to = (rank+1) * length/size;

//Intializing first and second array
if (rank==0)
{
    for(i=0; i<length; i++)
        for(j=0; j<length; j++)
        {
            first_array[i][j] = 1;
            second_array[i][j] = 1;
        }
}

//Broadcast second array so all tasks will have it
MPI_Bcast (&(second_array[0][0]), length*length, MPI_INT, 0, MPI_COMM_WORLD);

//Scatter first array so each task has matrix values between its boundary
MPI_Scatter (&(first_array[0][0]), length*(length/size), MPI_INT, first_array[from], length*(length/size), MPI_INT, 0, MPI_COMM_WORLD);

//Now each task will calculate matrix multiplication for its part
for (i=from; i<to; i++)
    for (j=0; j<length; j++)
    {
        result_array[i][j]=0;
        for (k=0; k<length; k++)
            result_array[i][j] += first_array[i][k]*second_array[k][j];

        //printf("\nrank(%d)->result_array[%d][%d] = %d\n", rank, i, j, result_array[i][j]);
        //this line print the correct value
    }

//Gathering info from all task and put each partition to resulat_array
MPI_Gather (&(result_array[from]), length*(length/size), MPI_INT, result_array, length*(length/size), MPI_INT, 0, MPI_COMM_WORLD);

if (rank==0)
{
    for (i=0; i<length; i++)
    {
        printf("\n\t| ");
        for (j=0; j<length; j++)
            printf("%2d ", result_array[i][j]);
        printf("|\n");
    }
}

MPI_Finalize();
return 0;

Now when I run mpirun -np 2 xxx.out 4 the output is:
|  4  4  4  4 | ---> Good Job!

|  4  4  4  4 | ---> Good Job!

| 1919252078 1852795251 1868524912 778400882 | ---> Where are you baby?!!!

| 540700531 1701080693 1701734758 2037588068 | ---> Where are you baby?!!!

Finally mpirun notice that the process rank 0 exited on signal 6 (aborted).
Strange point for me is where MPI_Bcast and MPI_Scatter work fine but MPI_Gather not.
Any help will highly appreciated

A: The problem is with how you are passing the buffers. You are doing it correctly in MPI_Scatter, but then do it incorrectly for MPI_Gather.
Passing the result_array as via &result_array[from] will read the memory where the pointer list is saved rather than the actual data of the matrix. Use &result_array[from][0] instead.
Similarly for the receive buffer. Pass &result_array[0][0] instead of result_array to pass a pointer to the position where the data lies in memory.
Hence, instead of:
//Gathering info from all task and put each partition to resulat_array
MPI_Gather (&(result_array[from]), length*(length/size), MPI_INT, result_array, length*(length/size), MPI_INT, 0, MPI_COMM_WORLD);

Do:
//Gathering info from all task and put each partition to resulat_array
MPI_Gather (&(result_array[from][0]), length*(length/size), MPI_INT, &(result_array[0][0]), length*(length/size), MPI_INT, 0, MPI_COMM_WORLD);

redpajama_set_name: RedPajamaStackExchange


Get A Taste of History At The Plymouth Cheese Factory!
Visit the second oldest cheese-maker in the U.S., the Plymouth Cheese Factory in Plymouth Notch, Vermont, for a tour, onsite museum, and – of course! – cheese samples!
The Plymouth Cheese Factory in Plymouth Notch opened over one hundred years ago, in 1890. The factory was started by John Coolidge, the father of Calvin Coolidge, 30th President of the United States, and continues to make cheese to this day.
It is said that Julia Child considered Plymouth Cheese her favorite – and who can blame her! The cheese-making tradition of Plymouth Cheese Factory goes back well over 125 years to a recipe that arrived with the first European settlers to the New World. Of course, the process has changed somewhat over the years but they still craft, cut, and wax their cheeses by hand.
Posted in Events and Attractions | Comments Off on Get A Taste of History At The Plymouth Cheese Factory!


text:
http://dapmalaysia.org
Lack of transparency and professionalism in the handling of the interim report of Royal Police Commission creating confusion whether it regards corruption as a serious problem most scandalous and does not speak well of the Commission, the government or police reform
(Petaling Jaya, Wednesday): The Prime Minister, Datuk Seri Abdullah Ahmad Badawi yesterday responded to the interim report of the Royal Police Commission suggesting that corruption existed "at every level" by pledging to eliminate corruption in the police force with the qualification that the clean-up will not happen overnight.
He said that as an immediate measure, any report lodged against police personnel will be investigated thoroughly with the necessary follow-up court action.
Such an unexceptional response does not promise any new political will or major crackdown on corruption in the police force, which is totally incommensurate with the gravity of a state of affairs where corruption has permeated all levels of the police force, with six areas, the commercial crime division, narcotics department, logistics department, anti-vice, gambling and secret service societies division and traffic police, specially named as particularly rampant with corruption – especially as this is the sixth year that Abdullah had been personally responsible for the police portfolio, first as Minister for Home Affairs since January 1999 and as Minister for Internal Security after the March 2004 general election.
However, before there could be a full and intensive national debate as to whether Abdullah's response is an appropriate one to the interim report of the Royal Police Commission on the permeation of corruption at every level of the police force, there is a ridiculous twist of events with the Chairman of the Royal Police Commission, Tun Dzaiddin Abdullah denying that he had made any statement about rampant corruption in the six named police divisions. Dzaiddin was reported in Sin Chew Daily today as denying that he had said in his media conference on 9th August that corruption in the police force was a serious problem.
The question Malaysians are entitled to know from the Royal Police Commission after six months of operation is whether corruption in the police force is a serious and rampant problem or not.
It is downright ridiculous that after the Prime Minister had responded by pledging to eliminate corruption in the police force, although without very convincing follow-up anti-corruption measures, the Chairman of the Royal Police Commission should be denying that corruption in the police force is a serious problem – reflecting most adversely either on the Prime Minister or the Commission Chairman.
The lack of transparency and professionalism in the handling of the interim report of Royal Police Commission creating confusion on whether it regards corruption in the police force as a serious problem is most scandalous and does not speak well of the Commission, the government or police reform to produce a world-class proferssional police service to roll back the crime wave in the country.
The latest flip-flop of the Royal Police Commission is further reason why its Interim Report should speak for itself, and why the report should be immediately made public without any further delay.
The Royal Police Commission proposes to visit other countries to learn from their experience and lessons of police reform. There is no need for the Royal Police Commissioners to go abroad to know that countries which have successfully carried out police reforms put a premium on openness and transparency, which have no hesitation in putting in the public domain their reports, studies and recommendations, whether interim or final, for public consumption and debate.
The Royal Police Commission should have insisted that its Interim Report should be made public to ensure continued public involvement in its deliberations instead of passing the buck to the government.
It would appear that the Royal Police Commission Interim Report has no immediate recommendations as to the urgent measures which the police should adopt to roll back the crime wave which have made Malaysians feel insecure and unsafe in the streets, public places and even in the privacy of their homes, which if true, will be a major blemish of the Interim Report. An immediate clarification from Dzaiddin on this matter will be most pertinent.
I have given notice to raise the issue of the Royal Police Commission Interim Report on the first day of the next parliamentary meeting on September 1, although I hope that by then, Abdullah would have already made the Interim Report public with an ongoing full-scale nation-wide debate about the Interim Report recommendations of the Royal Police Commission.
(11/8/2004)
* Lim Kit Siang, Parliamentary Opposition Leader, Member of Parliament for Ipoh Timor & DAP National Chairman

redpajama_set_name: RedPajamaCommonCrawl


You have the right to remain silent. This means that you do not have to talk to the police. Sometimes, police tell you that you do not have to talk. This is called reading you your rights or Miranda warnings because the police say that you have the right to remain silent and then they tell you what that means. But even if the police do not read you your rights, you do not have to talk to them.
It's better if you do not talk to the police.
If you do not talk to police, the fact that you did not talk cannot be used against you in court. For example, the judge cannot find you guilty just because you did not talk to police. Also, the judge cannot give you extra consequences just because you did not talk to police.
Police can lie to you to try to get you to talk. For example, they can say that they have videotape or fingerprints that they do not really have. Also, police can tell you that someone else told them things, even if that is not true.
Police can say that they will not press charges if you talk, but the police are never the ones who press charges. The people who press charges are lawyers called county attorneys who prosecute cases in court. County attorneys can press charges even when police promise not to.
Talking to police will not lower the chances of going to jail. Usually, police have already decided about taking someone to jail before even trying to talk to him. In fact, there have been times when police were not going to take someone to jail, but after the person talked to police, the person ended up being taken to jail.
Talking to police is very risky. You might say something without knowing that it hurts you. For example, not knowing that something is against the law is not an excuse. Also, sometimes police record it when they talk to you, but sometimes they do not. Police write summaries of what you say, and they may leave out what is most important to you.
If you are thinking about talking to the police, talk privately with a lawyer first. If you cannot afford a lawyer, a lawyer will be given to you. This is because you have the right to have a lawyer. You have the right to have a lawyer with you if you decide to talk to police. You also have the right to have your parents with you.


Rabbi Tatz visited JFS for his annual talk to students studying Religious Studies for GCSE. He is a doctor and world-renowned expert in Jewish medical ethics.
The Year 11 group, who are currently studying a unit focused on the topic of life and death, had a good opportunity to see how difficult situations are addressed and the thought processes involved when decision making in areas such as abortion and euthanasia.


text:
Q: Why don't integers "underflow" in PHP? If I do this in PHP:
echo (int)9223372036854775808;

The output is -9223372036854775808, which makes perfect since since 9223372036854775807 in binary is:
0111 ... 1

i.e., 0 followed by 63 ones. And obviously 1 in binary is just 1, so when I add them I get 1000...0 (1 with 63 0s after it) which is -9223372036854775808 in 2s complement notation.
So I would expect if I did something like add -1 to -9223372036854775808, I would get back 9223372036854775807. An analogy in 4 bit binary would be like:
1000   (-8)
1111   (-1)
----
0111   (7)

I understand that I can't simply assign -9223372036854775809 to a variable because there is no representation of that in 64 bit signed integers, but why doesn't this work:
$smallest_int = (int)-9223372036854775808;

echo (int)($smallest_int-1); //similar to 1000+1111 in 4 bit

When I run this the output is still -9223372036854775808. Why does that happen? Is it something to do with PHP's weak typing? Does this happen in other languages (I know it definitely doesn't happen in C)?

A: It's true that 9223372036854775808 becomes -9223372036854775808, but it's not so simple as just "integers wrap around". Here are a few more mappings (found by experimentation):

*

*9223372036854775809 → still -9223372036854775808 (not -9223372036854775807)

*9223372036854775810 → still -9223372036854775808 (not -9223372036854775806)

So you might think that numbers outside the int range all get mapped to -9223372036854775808 — but wait! :

*

*9323372036854775810 → -9123372036854775808

*92233720368547758080 → 0

All of which seems quite arbitrary to me. I think what's happening is that values that are over 18 digits long (and hence easily recognized as being outside the integer range) get essentially discarded and replaced with zero, whereas values that are 18 digits long get parsed just in case they are in range, but using logic that's not designed for, and not intended to be coherent for, values that are out of range.

A: I am guessing here that because the number is not typed, PHP is actually converting your number to floating and then -1 is lost in the maths.


HIGH POINT, N.C. – Ilias Kosmidis' brace led to High Point University men's soccer's third consecutive victory this Tuesday, pitching a 2-0 shutout against visiting Appalachian State.
The Panther defense was impenetrable in the opening 45 minutes against App State, blocking the only two shooting attempts the Mountaineer forwards were able to pull the trigger on. While neither side provided an abundance off offense in the first half, the hosting side would be the first to strike, after a hand ball from ASU in their own 18 triggered a penalty for the Panthers.
Starting forward Ilias Kosmidis delivered his sixth goal of the year in relaxed fashion, as the junior deposited his third PK opportunity of 2018 into the bottom left corner. Kosmidis' tally proved to be the difference after 45, as HPU took a lead into halftime for the fourth time this year.
It didn't take long for High Point to double their lead in the second, with Kosmidis picking up his second multi-goal game of the past week. Junior Jonathan Bolanos' ability to beat the Mountaineer defense one-on-one provided continuous opportunities for the Panthers throughout the night. The forward's strong dribbling led to his side's second score in the 48th minute, attacking the App State defense before laying a through ball to the streaking Komidis. The Grecian native responded with a perfectly aimed ball inside the right post, adding another pair to his now team-leading total of seven goals.
The Panthers proved to be the better team offensively in the proceeding 20 minutes, outshooting their opponents 4-1, twice coming within a yard of a third goal, on headers from Bolanos and starting striker Siggi Benonysson.
After making a mass sub, the Mountaineer offense attempted to up their own offensive aggressiveness, pulling the trigger on seven shots in the final 28 minutes of regulation. Goalkeeper Keegan Meyer, and the remainder of the HPU defense, would be up to task however, with Meyer making a pair of diving stops, and the 10 in front him recording four blocks.
With the ASU offense unable to penetrate High Point's defense, O'Keeffe's side would secure its third shutout victory of the season and its second consecutive. The Panthers have now gone a consecutive 197 minutes without conceding a goal, as their GAA for the season drops to exactly 1.00.
• High Point will try to continue its unbeaten run in conference play, facing off with Winthrop on the road this Saturday at 7 p.m.


I have a USI ITALIA AMU with 16,500 cfm , 12.5 hp motors, direct turbine blowers, recurculation bake, powerflame 950,000 btu indirect fired burner. It will come with the control box. The controls have bottons for pressure adjustment for intake and exhaust.The sale of this item is contingent on me buying the USI upgraded AMU. It works absolutly perfect with about 13k hours, and an intake and exhaust damper. I might be asking high, but if anyone out there has their opinion about pricing, I'm all ears. asking 18,500???????????


text:
Home Health Quoin Pharmaceuticals Announces Receipt of Constructive Scientific Advice from EMA for Q...
Quoin Pharmaceuticals Announces Receipt of Constructive Scientific Advice from EMA for QRX003 Development in Europe
Author PressReachPosted on August 1, 2022 August 1, 2022 Categories HealthTags editorial, pr
EMA Guidance Provides Clear Path Forward for Quoin's Netherton Syndrome Product in Europe
ASHBURN, Va., July 28, 2022 (GLOBE NEWSWIRE) — Quoin Pharmaceuticals Ltd. (NASDAQ: QNRX) (the "Company" or "Quoin"), a clinical stage, specialty pharmaceutical company focused on rare and orphan diseases, announces that it has received comprehensive and constructive Scientific Advice from the European Medicines Agency (EMA) for the clinical and regulatory development of QRX003 in Europe, as a potential treatment for Netherton Syndrome (NS).
This Scientific Advice was received in response to a Briefing Submission document filed by Quoin to the EMA on May 26, 2022. Based on standard review periods for such submissions, which may also include an in-person meeting with the EMA, Quoin had anticipated receiving feedback from the EMA in mid-September. Instead, the EMA truncated the standard review period and provided this Scientific Advice to Quoin without the requirement for an in-person meeting.
Quoin CEO, Dr. Michael Myers, said, "We are very pleased to announce the receipt from the EMA of this comprehensive and constructive Scientific Advice for the clinical development of QRX003 in Europe. Incorporation of key elements of the EMA's guidance into our existing US development plan for QRX003 will potentially result in a more robust data set that may ultimately be used to seek regulatory approval in both the US and Europe.
"While we continue to expand our network of supply and distribution agreements for QRX003, which now spans 60 countries, following our most recent announcements for Canada and Greater China, we remain fully focused on the clinical and regulatory development of the product in our core markets of the US and Europe. Receipt of this Scientific Advice from the EMA will support our development activities in those regions."
QRX003 is currently in clinical testing in the US in a randomized, double blinded, vehicle-controlled study that is being conducted under an open U.S. Investigational New Drug (IND) Application which will assess two different doses of QRX003 topical lotion versus a vehicle lotion in Netherton patients. The test materials will be applied once daily over a twelve-week period, to pre-designated areas of the patient's body. Based on discussions with the U.S. Food and Drug Administration (FDA), a number of different clinical endpoints will be assessed in the study.
The active ingredient in QRX003 is a broad-spectrum serine protease inhibitor, whose mechanism of action is intended to down-regulate the hyperactivity of skin kallikreins leading to a more normalized rate of skin shedding. If proven to be safe and effective, long term daily application of QRX003 could lead to the development of a more normally functioning skin barrier and a significant improvement in the quality of life of Netherton patients.
In conjunction with the company's strategy of self-commercializing its portfolio of products in the U.S. and Europe, Quoin has established a global network of marketing partnerships for QRX003 in 60 countries that will help support its mission of ensuring that every patient, everywhere, can access Quoin's products, once approved.
About Quoin Pharmaceuticals Ltd.
Quoin Pharmaceuticals Ltd. is a clinical stage specialty pharmaceutical company focused on developing and commercializing therapeutic products that treat rare and orphan diseases. We are committed to addressing unmet medical needs for patients, their families, communities and care teams. Quoin's innovative pipeline comprises four products in development that collectively have the potential to target a broad number of rare and orphan indications, including Netherton Syndrome, Peeling Skin Syndrome, Palmoplantar Keratoderma, Scleroderma, Epidermolysis Bullosa and others. For more information, visit:
www.quoinpharma.com
for updates.
Cautionary Note Regarding Forward Looking Statements
The Company cautions that statements in this press release that are not a description of historical facts are forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements may be identified by the use of words referencing future events or circumstances such as "expect," "intend," "plan," "anticipate," "believe," and "will," among others. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. These forward looking statements are based upon the Company's current expectations and involve assumptions that may never materialize or may prove to be incorrect. Actual results and the timing of events could differ materially from those anticipated in such forward-looking statements as a result of various risks and uncertainties. More detailed information about the risks and uncertainties affecting the Company is contained under the heading "Risk Factors" included in the Company's Annual Report on Form 20-F filed with the SEC on April 14, 2022, and in other filings the Company has made and may make with the SEC in the future. One should not place undue reliance on these forward-looking statements, which speak only as of the date on which they were made. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. The Company undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made, except as may be required by law.
Quoin Pharmaceuticals Ltd.
Michael Myers, Ph.D., CEO
PCG Advisory
Stephanie Prince
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A collection of resources related to digital forensics at Acumé Forensic and news from the industry.
Ana Kriégel murder
In the grounds of the Leixlip Manor Hotel there is a place of solitude to remember Ana Kriégel. It's a place where the 14-year-old girl played as a young child while her parents looked on, sometimes sipping a coffee inside. The death of a child is always distressing but the murder in extremely violent circumstances […]
Teen drug dealer murder
A window cleaner has been jailed for at least 22 years after he murdered a teenage drug dealer and hid the decomposing body in his attic for eight months. Gary Hopkins, 37, hacked 17-year-old Abdi Ali to death at his home in Enfield, north London. Abdi, a dealer linked to the violent Get Money Gang, […]
Sadie Hartley murder
An obsessive "she devil" who murdered a love rival in a brutal attack she plotted with a friend has been jailed for a minimum of 30 years. Sarah Williams, 35, stunned Sadie Hartley with a cattle prod and stabbed her 41 times in an "orgy of violence". She attacked Ms Hartley, 60, at her home […]
Satnam Singh murder
A 29-year-old has been charged with murder, a year after a man died from head and chest injuries. Satnam Singh, 74, was found on Coronation Street, Derby in July 2015. Police originally thought he had been hit by a car. Further investigations revealed Mr Singh had, in fact, been assaulted, Derbyshire Police said.
Nelson Cheung murder
Two "drug-addled, parasitic assailants" have received life sentences for killing a Co Antrim restaurant owner. Wing Fu Cheung, known as Nelson Cheung, was stabbed 18 times during a robbery in January 2015. Portuguese national Virgilio Correia, 35, of Grant Avenue in Randalstown, will serve at least 16 years in prison for the murder. Christopher Menaul, […]
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Conditions governing the expressions of interest for acquiring the club.
Reggiana presents the first compliances for the registration
Open Letter to the people of Reggio
Vice President Alicia Piazza's statement
President Mike Piazza's statement
The President Mike Piazza after Siena – Reggiana.
L'allenamento del 3 maggio.
Reggiana's condolences for the death of Rebecca Braglia
The Age of the Pioneers
The Postwar Period
The Epic of Del Grosso
Between the 60s and the 70s
Between '70 and '80
The Vandelli Era
In the Sign of Pippo
The Dal Cin Years
The Years 2000
Mapei Stadium
Regulation of Use
Banners Access
Supporter Card
Youth Sector
TIM Cup
Pool Granata
Stampatre and Ac Reggiana side by side for another year
Stampatre Litografia&Digitale, a reliable and accountable communication reality in the Reggio Emilia community, will still be part of the Pool Granata for the 2016/2017 season. It will be its third consecutive one. The renewal of the commercial partnership with the club has been sealed in these days and Ac Reggiana 1919 SpA is proud to…
#cuoregranata
Scatolificio Me-Cart Srl renews its presence in Pool Granata.
The Box Me-Cart confirms its presence in Pool Granata. A choice determined by the sporting passion that has always accompanied the property but not limited to: the sharing of an ambitious and important project for the city, positive and highly educational values that continues the Reggiana football are the reasons that led him Scatolificio Me- cart…
Hotel Boiardo yet alongside the Reggiana
Hotel Boiardo has confirmed its partnership with The AC Reggiana 1919 S.p.A. increasingly becoming the focal point of our president Mike Piazza for his journeys in Reggio Emilia. Hotel Boiardo is a passive building perfectly placed in the natural setting of the hills of Emilia, built with green materials and totally eco-sustainable. The goal is to…
New Cocolat Srl enters the Pool Granata
The beauty center, tanning and slimming Cocolat joins the Pool Granata. For all our sports will be the wonderful opportunity to combine a passion for sport to the possibility to spend pleasant moments of well-being. there is the "Sunday SPA" Among the many proposals of Cocolat. One Sunday a month for a relaxing day to…
M.T. Service Srl entra nel Pool Granata
AC Reggiana 1919 S.p.A. announces that today has reached the sponsorship agreement with M.T. Service Srl, a company founded in 2009 which is mainly engaged in the movement to provide goods and services to the ceramic companies. << I am particularly happy to have reached a commercial agreement with the Friends of Reggiana _ the…
Un nuovo ingresso nel Pool Granata: Emimed Srl
Emimed joined the Pool Granata. Emided since 2005, distributes medical devices and equipment throughout Italy and, recently, has been focused in the field of products for the Emergency-Urgency Area, Central 118 and Relief Services becoming distributor authorized for Emilia Romagna of defibrillators and monitoring products from the American company Zoll medical, world leader in this…
La Dumas Int. Ex entra a far parte del Pool granata di Ac Reggiana 1919 spa.
The Dumas Int. Ex joins the AC Reggiana 1919 SpA Pool grenade . "Our intent is to have a close relationship with the companies in our area _ remarks Paolo Pantaleoni Dumas Int. Ex. _ Even if our vision is a European and world level. The Reggiana is a perfect ambassador of our message, in especially…
OLMEDO BECOMES MAIN GLOBAL PARTNER OF A.C. REGGIANA SPA 1919
An ambitious project. A unique project. A project that involves a story of passion. These are the guiding principles that have guided the Quintavalli family to invest in the world of Reggiana Soccer. An investment in the long run it based on a two-year agreement, with an option for a further two seasons. "When we…
The Consortium of Parmigiano-Reggiano becomes part of the granata family.
The body of protection, in fact, will be alongside dell"Ac Reggiana 1919 thanks to an agreement that further highlights its profound link with the world of sport and, from basketball to football, with the excellence of Reggio Emilia in the competitive field. "This agreement – underline the President of the Consortium, Alessandro Bezzi – is…
Nuova Castelli and Reggiana together for the next 3 years
Nuova castelli will be for the next three years, with possibility of renewal for another three seasons, the official sponsor of Reggiana Calcio. The duration of the agreement shows clearly the willingness of the group to accompany Reggiana Calcio in a sporting development path. An important commitment, significant and which attests the esteem and trust that Nuova Castelli…
A.C. REGGIANA
A.C. REGGIANA 1919 S.p.A.
Sede Legale: Via Mogadiscio, 1 42124 Reggio Emilia (RE)
Conditions governing the expressions of interest for acquiring the club. 1 July 2018
Reggiana presents the first compliances for the registration 29 June 2018
Via Mogadiscio, 1 42124 Reggio Emilia
segreteria@reggianacalcio.it
Copyright (c) 2016 A.C. Reggiana 1919 Spa


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Justicia schoensis är en akantusväxtart som beskrevs av Gustav Lindau. Justicia schoensis ingår i släktet Justicia och familjen akantusväxter. Inga underarter finns listade i Catalogue of Life.

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Akantusväxter
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The videos are of a recent job our team completed for one of our our private clients.
This is a large 4 bedroom detached bespoke build out in the country on the outskirts of Wadebridge.
Our first process is to cover all flooring. In this development our client had a huge slate floor put down on the ground floor of the property. This included the main hallway right through to the large kitchen diner area and right down the back hallway to the garage including a downstairs bathroom and utility area.
We always cover our floors when spraying with a covering called ' Ram Board '. This is a compressed cardboard covering which is very strong and will resist Water spilliages, paint spillage and is scuff resistant.
This is a great covering to put down while all your trades are working in these areas and guarantees that the floor covering that you put down, whether it's wood or slate is very well protected until the end of the Build.
We tape all edges to the bottom of walls when spraying then all the developer or client has to do is take of the tape on the boundary and trim off the Ram Board by about an inch all the way round so that the carpenters can fit the skirting board above the floor covering.
We would then on the second phase of Decorating re-tape all around the edge with our specialists tape guns and Kleenedge precision masking tape to sit just underneath the skirting boards so that the finish top coats can be applied.
This particular Ram Board came from Travis Perkins and 3 rolls was used to cover this huge slate floor. They sell the tape separately to the rolls which is a really sticky strong tape which won't peel off so it can be swept or hoovered on a daily basis.
The advantages are second to none with this floor covering which speeds up trades that are on price because they can work quicker which means the development moves quicker.
We mask off all windows and doors with our specialist masking sheeting guns and again use our precision masking tape to ensure all pre finished windows and doors are immaculate once we have completed our spraying.
As you can see in our photographs our finish is an immaculate spray finish with 2 coats. Also in the photographs you will see how we have taped up the whole stair case as this is made of Ash wood and the client wants a clear lacquer finish on this eventually so it's really important no overspray gets on the stair stringers or mule posts etc.
What this means is that on the second phase of Decorating after all trades have second fixed is that we have minimal filling to do as during the first phase before spraying, our team sand all the plaster as flat as we can , apply 1 mist coat spray with watered down paint through our sprayer then alter our settings on the sprayer and applying a second spray with a slightly thicker consistency.
Our Clients were over the moon with this finish and we've managed to bring their schedule forward by 3 weeks.
This particular spray job took 2 days for 2 of our team who are specialist sprayers to complete the whole 4 bedroom house which included protecting the floor detail and hoovering the plaster up after sanding ready for spraying.
Another great job achieved and another happy Client.


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Home / Records / News
The Bongolian 'Harlem Hipshake' new album announcement.
Blow Up Records is pleased to announce The Bongolian brand new album 'Harlem Hipshake' will be released 13/11/2020. It will be the sixth album under The Bongolian moniker, AKA multi-instrumentalist and Big Boss Man front man Nasser Bouzida. It is the much anticipated follow up to the highly acclaimed Moog Maximus and is available to pre-order now in the following formats: Clear 180g vinyl (limited 500 ), black 180g vinyl, CD and digital from the Blow Up (greedbag) shop: https://blowup.greedbag.com/buy/harlem-hipshake/
Harlem Hipshake finds The Bongolian deeply immersed in his lifelong love for the music of the sixties New York's Latin Soul scene, particularly the music of Ray Barretto, Mongo Santamaria and Joe Bataan. Principally a drummer, percussionist by trade, Nasser has once again delivered another set of heavy breaks and percussive grooves underpinning this brand-new collection of songs which he has written and produced. Whilst Nasser performs many of the instruments (as is usual with Bongolian albums) on the album, it also features a prominent use of additional UK musicians on brass duties. These include Terry Edwards (Trumpet, Trombone, Sax, Flute), Gareth James Bailey (Trombone) and Craig Crofton (Alto Sax), James Morton (Alto Sax), Andrew Ross (Tenor and Baritone sax) and Ralph Lamb (Trumpet).
From the East Side to the West Side, get ready for the Harlem Hipshake.
Aspic Boulevard 'Memory Recall of a Replicant Dream'as reviewed by Shindig Magazine
"It's quite a bold experiment nonetheless, as indeed is the whole LP. One to watch." Aspic Boulevard 'Memory Recall of a Replicant Dream' as reviewed in the current issue of Shindig! Magazine… the latest!
Normal Life by David Woodcock featured on Janice Long (BBC Wales)
Janice Long played Normal Life by David Woodcock on BBC Wales introducing fresh new music and artists from Wales.
"Do you know what I absolutely love that, Normal Life from David Woodcock and there's nothing normal about the construction of that, there's an absolute Madness about it, It could be in a show couldn't it? Or it could be vaudeville, magnificent stuff."
JANICE LONG, BBC
The track immediately follows another vaudeville inspired romp The Damned 'Grimly Fiendish' at 2:20:10.
Following the Aspic Boulevard Akragas world exclusive video premier by ROCKERILLA magazine on Monday, the video is now available to view on You Tube.
David Woodcock Normal Life video premier Friday 4th June.
Watch the exclusive video premier for the David Woodcock single Normal Life Thursday 4th June at 7pm. It will be launched via the Blow Up Records You Tube channel.
There's Old Normal, There's New Normal, And There's David Woodcock.
Aspic Boulevard Akragas video is exclusively premiered by ROCKERILLA magazine today.
VLR writers top five albums of 2019
Thanks to Dave Collins at Vive Le Rock for the support for David Woodcock Normal Life and Usselman All fun And Games Until Everyone Goes Blind as they both make it into his VLR writers top five albums of 2019 in the latest issue with cover stars The Specials (Official).
On Fire has now hit over 1 million streams on Spotify
Congratulations to Neon Plastix – On Fire has now hit over 1 million streams on Spotify, the track is taken from the album Awesome Moves
Usselman are live in London at 93ft East
Friday 29th Nov – Usselman are live in London at 93ft East.
It's their first London appearance since the release of debut album 'All Fun And Games Until EveryOne Goes Blind'. Check venue listings for confirmation of stage time.
Baltic Fleet Rolling In Oceans Tide EP all tracks are now available to download
Exclusive – Ahead of the official release of Baltic Fleet Rolling In Oceans Tide EP – 11/11/19 all tracks are now available to download exclusively from the Blow Up Records (Greedbag) shop.
Limited edition of 100 only – Blow Up 25 Tote Bag
Limited edition of 100 only – Blow Up 25 Tote Bag – as sold at the Blow Up 25 concert at The 100 Club are available to order direct from the Blow Up Records shop (Greedbag). Grab them while you can!
https://blowup.greedbag.com/buy/blow-up-37/
Aspic Boulevard – New Blow Up Signings
We are pleased to announce new signings Aspic Boulevard, here is a taster from what will be their debut album 'Memory Recall of a Replicant Dream'…
Sicilian brothers Alessandro and Marco Barrano take a journey through space and time with a sound is characterized by vintage electronics: analogue keyboards, analogue drum machines, tape recorders, circuit bending and many homemade musical instruments. Influences range from Pierre Schaeffer and Musique concrète school in France in the early 40's to the sci-fi nuances of 60s & 70s cinematic music, psychedelia and kosmische. Composer Marco Barrano is of course no stranger to Blow Up Records having previously released MHz Invasion as one half of Daiquiri Fantomas which received support at BBC 6 Music from DJs including Radcliff & Maconie and Steve Lamacq.
Listen on Soundcloud »


This is the ninth part of the Free to Play Journeyman Hearthstone Guide Series. Be sure to check out the other articles in the series here: Part 1, Part 2, Part 3, Part 4, Part 5, Part 6, Part 7 and Part 8.
The flickering light casts dancing and occasionally ominous shadows across the rock ceiling of the long forgotten cave. You pay them no heed as you bow your head over the torn and weathered parchment, brow furrowed as you decipher the ancient writing. A map, but not just any map. A guide. Many have travelled this way, some of whom even had this very item in their grasp, and yet they either returned empty-handed or returned not at all. The signs are obvious; avoid the traps, cross the naturally formed stone bridge, through the dense vines, and the destination lies before you. Something must be wrong for such simple instructions to fail so many. Unless they also thought it was a trap, of course. Unless they decided the more obviously dangerous routes might not be so treacherous after all. It takes courage to do what others have not done, even moreso when it requires faith in one's own, unproven judgement. What if you're wrong? What if only despair awaits? Your mind clears. Travelling this way was always likely to end in despair. So many have tried and failed, why should you expect a different outcome? Free of doubt, you roll up the parchment and return it to your pack. Deep breath. And go... Um? So that was easy. Throughout this series I have stressed the importance of spending dust only on Legendary minions. Common perception is that if one spends significant dust crafting cards of lesser rarity, these cards will inevitably be opened in packs and can only be disenchanted for much less dust than was spent crafting them. Given that dust is difficult to accumulate unless one averages at least 5 wins per arena run or if one has the time to maximise the 10g per 3 wins quest (which can be completed at most 10 times each day), this waste comes back to haunt one. There is nothing false about this perception whatsoever. The facts there are absolutely true. But what they do not account for is a) how often such dust actually proves to be wasted in the long term, and b) how much faster one can earn dust with the cards so "hastily" crafted. I know what it is like to be slapped down hard by the pack RNG. On my EU account I spent the first two months disenchanting every spare card to build up a set of core rares, especially neutral ones, in order to play decent decks in every class. The week I spent 200 dust to craft a playset of Wild Pyromancer I subsequently opened 3 more. Rather than gaining 20 dust, I had spent 140; that's another rare and a common and a half of choice overall (160 dust total difference). But you know what? That was as bad as it got. While it is true that I "wasted" somewhere in the region of 500 dust accumulating my collection (I no longer purchase Classic packs with that account, btw, so 500 is the maximum loss), some of which actually came back when I opened golden versions of cards I'd crafted (for instance the golden Doomguard I got from my Tavern Brawl pack this week), the truth is that 500 dust really isn't very much in the grand scheme of things. I've spent so much time avoiding crafting rares I know I need on my Free-Play US account, that perhaps I've stunted the growth of my collection in other ways. This season I finally took the decision I knew needed taking: craft the cards I will need to craft in the Goblins vs Gnomes (GvG) set because I'm not going to open packs from that set by choice. Or at least, craft the significant ones. I disenchanted a fair number of the commons and a few rares from the list I presented last time to accumulate 400 dust, and together with some dust on hand I crafted the following: Unstable Portal , Clockwork Gnome , Antique Healbot , 2 Glaivezooka , 2 Shielded Minibot , and 2 Piloted Shredder . Sadly, the Portals, Gnome and Healbot did not elevate my Mage deck into anything particularly useful despite owning Archmage Antonidas , but I gained a proper appreciation of how important Flamewaker is to the class, and therefore raises the question of when rather than whether to save money for the Blackrock Mountain adventure. Besides, I will always play the Portal in Mage, and the healbot is infinitely useful, so even if I never use the Gnome again, so what? 40 dust is a small price to pay for the insights gained by actually trying to build an Antonidas deck. And besides, the Shredders alone made all the difference between my regular rank 13 and the season high shown in the screenshot above: rank 10 with 2 stars, which is my best rank to date on this account. At rank 10 one earns 40 dust more from the end of season chest compared with rank 13 as there is an extra golden common but 10 less dust; perhaps I should have done this earlier? As the title says, surely not? How can one card make so much difference?
In truth it's not just about the Shredders, but rather in how the Shredders make a deck built around them punch well above its weight; the sum of the parts becomes greater than the whole. Let us consider the deck highlighted in the screenshot above: Deathrattle Shaman. If you'll pardon the pun, there's an overload of strong minions with deathrattle effects in the list, but previously without the Shredders I relied on Sludge Belcher . Not only is the card a turn slower with less aggressive stats and secondary minion than the Shredder, sometimes one holds the Belcher even when drawn on curve because the opponent has not sufficiently developed his board that one requires a taunt at the time. Rather not give the opponent the chance to silence or kill it just because he has nothing better to do. Whereas the Shredder is probably the deck's strongest turn 3 play with the Coin; a significant improvement in tempo, especially when followed with Baron Rivendare and a double trigger the following turn. It's only that single playset of cards different from the previous deck, which was already decent, but in 9 games with the deck I lost only 1 in the mid-teens ranks - enough to complete 2 daily quests with the minimum of fuss, which is exactly what my busy family life needs. 80 dust to reduce my playtime by between 2 and 3 games to achieve the same result? Worth every ounce of the stuff... It's quite remarkable how a simple change to a deck's composition makes it play like a completely different deck. The change in tempo mentioned above aside, the difference between a largely defensive creature and a more aggressive one changes the player's mindset as well. No longer are we going to wait to see how the opponent develops his board in order to calculate the best way to improve trades, instead we are going to attack the opponent's position and force him to make poor trades. No longer are we going to wait to see how to react to the opponent's strategy, instead we are going to dictate the game's strategy and will win if the opponent cannot impose himself on the game. There is a saying core to the principles of the ancient Chinese martial art of Xing Yi Quan, that "When the opponent attacks, attack, and when the opponent waits, attack". In this way you dominate the fight, and fights are most often won by the more dominant fighter. While this Shaman deck is not a "face" deck it takes the board aggressively, and that is often enough to secure victory.
But reaching rank 10 was not down to Shredders or Shaman alone, of course. The cornerstone of the win streaks was my new and improved Hunter deck. Previously I had never managed better than a win ratio of about 40% with whatever strategy I tried; without key cards like Knife Juggler and especially Eaglehorn Bow I simply had no price. But this season I suddenly got the card balance right. 10-1, the loss being a rare bad draw, does wonders for one's ranking when starting already on a win streak. I will admit to being lucky that the change in the environment post-Patron Warrior hurt Face Hunter's traditional foils, especially Priest, to the extent that I largely played against decks that were good match ups anyway. But like the addition of Shredders to my Shaman deck, bringing in Glaivezooka was instrumental to this deck's success. With weapons at its disposal the Hunter can attack on all fronts, maximising the use of simply going to face with its minions while controlling the board with other means - a more aggressive and deadly Rogue, in a way. Like all Face decks, although fairly simple to play one must on occasion spend one or two moments controlling the board with minions as necessary. The decision of when this must happen is crucial to success, and fortunately I have quite a lot of experience playing this style of deck as my initial journey with my EU account revolved entirely around playing Zoo decks with both Hunter and Warlock. Since I still do not own Knife Jugglers or Eaglehorn Bows I can't go "full aggro" by omitting the Shredders and running a second Arcane Golem , even though I actually own the card and it looks at me with puppy eyes each time I page past it in the collection browser. I need a slightly more "mid-range" feel to the deck, hence the addition of Webspinner s which are not typical of Face decks. The Bear Trap reinforces the early game perception that I'm using a mid-range strategy, where the Bear is commonly paired with Freezing Trap . Confusion in the mind of the opponent allows one to "change gears" as the opponent nears the Hunter's long reach, and bursting an unsuspecting opponent down from 15 life or more is quite common; you know he's got the Healbot but he didn't think he needed it, and now it's too late.
And of course, there's more. In the time between this article and the last I opened 17 Classic packs. Highlights included: Golden Harvest Golem , Aldor Peacekeeper , Freezing Trap , Lay on Hands , the Arcane Golem mentioned above, Sea Giant , Coldlight Oracle , Dire Wolf Alpha , Armorsmith , Eviscerate , Brawl (obtained from the gold rewards from the 5 wins in Tavern Brawl quest, ironically), Shadowflame , SI:7 Agent , 2 Mana Tide Totem , Golden Silver Hand Knight . Oh, and another 400 dust potential in another Onyxia . Oh. And this: Surely not, indeed! I promptly disenchanted these two legendary minions along with the Hogger that was now sitting idle in my collection having been made obsolete by crafting Sylvanas Windrunner a few weeks ago. The scrap from these 17 packs plus a few extras left over from my collection garnered me the other 400 dust needed, and I crafted Ysera . While I don't have an immediate use for the card due to a lack of many key cards of lower rarity that support control strategies, it can easily slot into my priest deck (especially if I revert to a "build-a-monster" style) as well as being a solid inclusion in Paladin. This craft, along with the Lay on Hands and the Aldor Peacekeeper mentioned above (my second), and combined with the previous crafting of a Shielded Minibot playset, paves the way to target Tirion Fordring and 2 Muster for Battle (GvG card) with my next 1800 dust. Hopefully those Knife Jugglers are not too far away... Look out control decks - here I come! As always, please feel free to comment or criticize below and thank you for your time.


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Trasimeno 2022
the lake and its villages
Trasimeno Lake
How to get to Trasimeno
Certified Environmental Quality
Trasimeno nearby
The Lake Trasimeno area
The Park and the Islands
Home » Itinerary » History and culture » The Land of Men of War
The Land of Men of War
As you near Tuoro you immediately grasp what the great Carthaginian general Hannibal also innately understood when he chose this as the place to surprise the Roman troops of his enemy, the Roman Consul Caio Flaminio Nepote, in what became known as the Battle of Trasimeno, one of the bloodiest of the 2nd Punic War. At dawn on June 24, 217 BC, Hannibal took advantage of the thick fog and led a ferocious attack against the Roman troops. Ten thousand of them died in battle that day, some killed by Hannibal's men, others by the sword of their fellow soldiers in order to avoid capture, while many also died drowned in the Lake. That notwithstanding, many were nonetheless captured. The battle remains an integral part of the area and its history, and visitors today can tour the fields, which apart from its archaeological interest are also set in beautiful surroundings, and read about the events of that terrible day.
Another of Trasimeno's towns is also famous for the warring activities which took place there: Castel Rigone, a hilltop town near Passignano sul Trasimeno. In 543 AD, the story tells, the Ostrogoth Arrigo (or Rigone), a lieutenant under General Totila, set up an operational base here in his efforts to sustain the siege of Perugia. Towards the end of the 13th century a castle, of which the walls, the keep, three towers and two gateways still survive, was built here to defend its local inhabitants.
Standing on the top of the hill of Castel Rigone, if you look out towards the shore on the other side of the Lake, you can still hear the clip-clop of a trotting horse ridden by a great adventurer who lived in the mid-1300s. His name was Boldrino Paneri and he was born in Panicale in 1331. Thanks to his many victories in defense of Perugia, he was honoured with the keys to the city. The episode was immortalized by the artist Mariano Piervittori on a large tapestry which now hangs in the Teatro Caporali, a tiny architectural gem made of wood and entirely embellished with stucco decorations. Walking the streets of Panicale you can stroll along via Boldrino Paneri and admire the 13th century building in which he was born. His family heraldic shield still adorns the façade.
Moving towards the south-west we find Paciano, on the slopes of Mount Petrarvella, with its ages old castle. In 1509, for their loyalty to the Church, the Pope exempted all of its citizens from taxes because in the ongoing power struggle between the noble Oddi and Baglioni families of Perugia, they sided with the Oddis. Legend has it, in fact, that Adriano Baglioni was actually poisoned in Paciano in 1502. Along the panoramic Ceraseto road that connects Paciano to Città della Pieve one can still see the ruins of the ancient Giano temple, and it is likely that the town of Paciano got its name from being a "Passaggio al tempio di Giano", or "a stop along the way to Giano".
Leaving Paciano in a southwesterly direction one arrives in the area of Città della Pieve and Castiglione del Lago, both towns with ancient medieval origins closely tied to the famous adventurer Ascanio della Corgna. In their very centre and embraced by their majestic walls, rise the fascinating renaissance buildings constructed ay the behest of the Della Corgna family in both towns, designed by architect Galeazzo Alessi. They are still graced with original frescoes painted by Niccolò Circignani, known as "il Pomarancio", and they depict episodes of Ascanio's many adventures and service to his fellow citizens. Ascanio della Corgna (1514-1571) was the perfect example of a gentleman and adventurer, blessed with the strong humanistic vein typical of the Renaissance. He was one of his era's most illustrious figures and distinguished himself in many fields. He studied architecture and was an excellent swordsman, well acquainted with both the art of battle and the humanistic passions typical of his times. He fought in almost all of the wars that raged around him, soldiering under different banners at different times. He was renowned far and wide for his swordsmanship, so much so that some three thousand people travelled to see him in a duel with Giannetto Taddei, a man who had offended him. A fresco portraying the duel can be admired in Palazzo della Corgna in Castiglione del Lago. He died in 1571 after having fought in the Battle of Lepanto and his body still rests in the Della Corgna Chapel in the Chiesa di San Francesco in Perugia.
Andrea Fortebraccio (1368-1424) was known as Braccio da Montone in honour of a village not far from Città di Castello and was another fine soldier and adventurer. His life was spent fighting in wars and battles, during which time he perfected a military technique based on quick maneuvering and rapid movements. It was something of a new way of doing battle and became known, in his honour, as the braccesca technique. It was not unsimilar to the style of attack used by Hannibal when he defeated the Romans in the bloody Battle of Trasimeno.
Braccio had several exceptional pupils, one of whom was Niccolò Piccinino, born in Caligiana di Magione in 1386. He took part in the Battle of Anghiari and led his troops to glorious victory. Leonardo da Vinci immortalized this battle in a fresco which can be admired in Florence, a copy of which – made by Peter Paul Rubens – hangs in the Louvre in Paris.
Magione also played something of a role in the often sanguine events of the Renaissance, records of which are preserved in Niccolò Machiavelli's The Prince, his famous political doctrine. This "immortal" book recalls the importance of the Castle of the Knights of Malta in Magione, where one of the most famous military conspiracies was hatched against the powerful Cesare Borgia, known as "il Valentino". Machiavelli had seen him as the ideal military man and, above all, the ideal Italian Prince who could have achieved the unification of Italy. In 1502 Cesare Borgia survived a conspiracy plotted against him by the military leaders of various central Italian cities. These men had gathered at the Castle of the Knights of Malta, a fortified hospital built in the 12th century, to find a way to stop his expansion of power. The plot was discovered, however, and the traitors either killed or sent into exile.
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text:
REVIEW by Seki Lynch
NWR Issue 98
by Richard Poole
Richard Poole's poetry collection Camelion is an interesting series of poems written in the voices of both fictive and historical characters. The title poem, introducing the work in the prologue, sets up a morphing collection that shifts from Nero contemplating his place in the ages while examining himself in a mirror, to three jealous prostitutes bitching behind each others backs and Dorian Gray's picture giving its interpretation of past events. Gods, vampires and animals all make an appearance in this ambitious amalgam of verse. But if poetry aims at the perfect expression of the truths of the world through a fictive or factual framework, then somehow the wonder which should accompany it seems to be missing from Camelion.
Poole is primarily a fantasy writer, and it is easy to see in this collection that he has an imagination gifted in the rendering of worlds. His command of language and possession of a distinct voice are also evident. Still the reader is left wanting. Most probably the reason for this concerns truth. Though Poole's use of the first person gives his lines immediacy, it also presents a problem. Self- awareness in protagonists can be an effective device, but there is a need for delicacy in its employment; while egotistical characters may or may not be forgiven, the real measure of whether a self-aware character is successfully drawn is the credibility of his or her voice. The two main ingredients of this credibility are, first, the way something is said (the idiosyncratic intonations of speech) and, second, what the character is actually saying. While the former is often the harder of the two to make convincing, it seems that it is the latter which is the more troublesome for Poole. In Camelion, the reader finds that what is said often undermines the authority a first person perspective should bring. The reader asks, 'Who really thinks this way about themselves.... Perhaps one or two characters, but all of them?' One can only assume that the voices given to these characters have been designed to talk about them rather than as them, and that the first person frame is a way of making this experience feel more intimate. The self-declarations sound false because the descriptions of self are based on the ideas and opinions of others, whether these have been formed over time (in relation to historical characters) or through critical interpretation, reading and rereading (in relation to fictional characters). The characters talk about themselves through the filter of the poet's imagination, and while Poole has truths to tell, the characters aren't allowed their own – they are characters speaking of their own caricatures, puppets speaking of the things they mimic. The reader wonders if Poole has let romanticism lead the writing of these poems. If so, perhaps they can only be enjoyed if we are able to indulge ourselves along with him.
That said, Poole's technical abilities are evident, and lines of excellence do occur when coupled with characters' contemplation of things other than themselves. Often these contain details which offer insight into the world of the poem, illuminating pieces of life. One such example is in 'Dinner At The Ambassador's', 1584:
Lord H. toys with the partridge on his plate. It is tough
and he is a fastidious man. It has not been hung enough
to fetch the flavour out, the rank gameyness of the thing –
and the gameyness of the game, naturally, is everything. But
Lord H. is brilliant, and brilliance is dangerous.
Still one notices here that the observation comes not from Lord H. himself, but from the guest. 'Tut-ankh-amon in his Tomb' also has some beautifully crafted lines:
Lying with flowers in the darkness,
wild celery, leaves of the willow,
strewn petals of blue lotus,
woody nightshade, the mandrake's fruit,
I can smell none of these, I dream
Though this works better than Nero's bragging 'Nothing you can imagine can appal me, nothing', it still has the flavour of a person talking about someone else, rather than about themselves.
One surprising element of Camelion is the humour, present in poems such as 'Advice to Virgins' in which the speaker in the poem rebuts Fanny Fern's axiom 'The way to a man's heart is through his stomach' by stating:
Don't cook your goose with Fanny's ancient lie:
the way to a man's heart is through his fly.
Ultimately the merits of this collection contribute to its frustrations, as the reader is constantly aware of potential unfulfilled. There is no questioning the scope of Camelion, nor Poole's skill in the crafting of verse, but readers will too often find themselves searching amongst these lines for magic, which, like the chameleon, is no sooner spotted than disappears.
previous review: Beasts of the Southern Wild, Film Review
next review: You, Me and the Birds


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Tony Evers announces 60 new assistant district attorney positions in 56 counties
topical top story
GOV. EVERS | PROSECUTORS
Mitchell Schmidt | Wisconsin State Journal
Gov. Tony Evers after signing the budget in July. Evers made 78 partial vetoes to the state budget passed by the Republican-controlled Legislature before signing it.
STEVE APPS, STATE JOURNAL
Gov. Tony Evers has announced the addition of more than 60 new assistant district attorney positions across the state, a move he called the largest state investment in the district attorney program in Wisconsin history.
Evers said in a Tuesday statement the new hires will represent the first new full-time general purpose revenue-funded positions created for the program in more than a decade.
"For far too long our county district attorney offices have been doing more with less," Evers said. "This historic investment will enable our county officials to improve victims services, enhance diversion and treatment options for those struggling with substance use disorders, and address backlogs that are standing in the way of justice."
Allocation recommendations from the Department of Administration were made based on requests by county district attorneys. Fifty-six counties are slated to receive a total of just shy of 65 new positions.
Milwaukee County is slated for three new positions, Dane County is poised for 1.15 new positions and La Crosse and Fond du Lac will each see two new assistant district attorney positions.
Evers' spokeswoman Melissa Baldauff said counties likely will have discretion on hiring for the positions, including on pay.
The typical starting salary for an assistant district attorney is about $25 an hour and, over the two years of the budget, the total staffing increase is expected to cost about $7.8 million, Baldauff said.
Sen. Andre Jacque, R-De Pere, said more investment is needed in assistant district attorneys but the new positions mark a crucial step forward.
"I am pleased that the uncertainty over prosecutor allocation for counties has ended, and that DOA's recommendations are similar to its prior analysis, including several assistant district attorneys that will be added in Northeast Wisconsin," Jacque said in a statement.
Tony Evers facing pressure to sign or veto Wisconsin budget
SCOTT BAUER Associated Press
During the budget process, Republicans, who control the Senate and Assembly, had originally earmarked funding for new district attorneys to specific counties.
However, Evers vetoed the earmark and directed the Department of Administration to work with the State Prosecutors Office to allocate positions to counties "in a manner that considers need holistically, including staffing needs based on creation or expansion of treatment alternatives and diversion programs, meeting with victims prior to charging, addressing backlogs, and utilizing available workload analyses," according to the governor's veto message.
Sign into law? Veto entirely? Partial veto? Gov. Tony Evers has 6 days to decide on budget
Kelly Meyerhofer | Wisconsin State Journal
Rep. Gordon Hintz, D-Oshkosh, said in a statement the district attorney staffing shortage is one of the biggest barriers to criminal justice reform.
He added that two new assistant district attorney positions in Winnebago County "will help enhance treatment and diversion options, address backlogs, and improve victim services."
Rep. Mark Born, R-Beaver Dam, raised concern that Milwaukee County is slated for three new assistant district attorney positions, while Manitowoc and Monroe counties will get only one each.
"Governor Evers' decision today to take district attorney positions away from understaffed rural counties to give more to Milwaukee County is very concerning," Born said in a statement. "Picking political winners and losers when it comes to public safety is the wrong way to govern."
Politicsother
State-government
State Prosecutors Office
Department Of Administration
Follow Mitchell Schmidt | Wisconsin State Journal
Who are they? WI children recently reported missing
These are recent reports of missing children made to local law enforcement. If you think you have seen a missing child, contact the National C…
With veto pen, Gov. Tony Evers 'finally able to move the needle' on GOP budget
The governor was able to use his partial veto power to increase net K-12 spending by $65 million.
Abnormal warmth continuing for south-central Wisconsin leading into possibly stormy weekend
The area should see highs in the low 80s heading into the weekend, and still in the 70s through the middle of next week, according to forecasters.
Authorities identify Madison man who died in crash into power pole in Monona
Authorities have identified the Madison man who died in a crash into a power pole in Monona on Monday night as 21-year-old Joseph M. Swenson.
Lafayette County authorities identify car, driver who crashed into Amish buggy and fled
No charges have been issued as of Wednesday morning as the crash remains under investigation.
Tony Evers, Democratic lawmakers unveil bill package as 'first step' toward criminal justice reform
Gov. Tony Evers and fellow Democratic lawmakers have introduced a package of three bills aimed at taking the "first step" toward criminal justice reform in the state's crowded adult prison system.


text:
Q: The basic of the count
(a) A computer network consists of six computers. Each computer is directly connected
  to at least one of the other computers. Show that there are at least two computers in
  the network that are directly connected to the same number of other computers.
(b) Find the least number of cables required to connect eight computers to four printers
  to guarantee that four computers can directly access four different printers. Justify
  your answer.

A: HINTS:

*

*Pick any one of the six computers; to how many others can it be connected? We're told that it's connected to at least one, and there are only five others, so it must be connected to $1,2,3,4$, or $5$ other computers. The same is true of each of the six. That's how many different possibilities?

*This problem is very poorly worded. It could mean that there are at least four computers, each of which can access all four printers; that there is some set of four computers that altogether can access all four printers; or that no matter what four computers you pick, those four can access all four printers. I suspect, however, that the last of these is intended, since the first two are trivial. The best way to attack it is probably to ask yourself how many cables you can install without meeting the requirement. For instance, is you connect each of the eight computers to the same three printers, you've used $8\cdot3=24$ cables, and no set of four computers can access all four printers. How much worse can you do? How many more cables can you install and still have at least one set of four computers that can reach at most three of the printers?

A: By Pigeonhole principle:
the connections each computer can have is 1 or 2 or 3 or 4 or 5 (these are 5 holes)
the number of computers is 6 (these are pigeons)
therefore, there will be at least 2 computers having same number of connections

A: (a) There are six computers, and each computer connected to at least one of the other five computers, this means the possible connection for each computer is: 1, 2, 3, 4, 5, by using the Pigeon and Pigeonhole Principle, let these 5 possible connections be the Pigeonholes, and let the six computers be the Pigeons, therefore there are must at least two computers have same number of connections.
(b) First, think of the worse case, there are 8 computers and 4 printers, so the worst case would be all 8 computers have access to 3 printers, but non of them have access to 4 printers, that is $8\times3=24$ cables. Now, since each computer has access to 3 printers, then you can just add 4 cables, so that there must be 4 computers have access to all 4 printers. Thus, the number of cables that guarantee 4 computers have direct access to all 4 printers is $24+4=28$

A: As for b)
I was doing exercises in the Discrete Mathematics and Its Application book and stumbled across the same exercise, my solution was to connect five computers to all four printers at the total use of cables to 5*4 = 20, then there is no way to pick four computers without picking at least one which is connected to all four printers.
As far as I can tell the part with the computer connected to each other is only for exercise a).


text:
Review. Chemical convergence between plants and insects: biosynthetic origins and functions of common secondary metabolites (New Phytol)
May 3, 2019 /in Plant Science Research Weekly /by Laura Mejia
Plants and insects aren't closely related, but they have a plethora of similar chemical weapons used for their interactions (defense, attraction, etc.). Beran et al. describe the function and biosynthesis of secondary metabolites that are shared in both insects and plants.
The monoterpenes and sesquiterpenes used for inter and intraspecific interactions. These molecules are formed from isopentenyl diphosphate (IDP) produced through the conserved mevalonate pathway (MVA); the enzymes used in plants and insects are different. Plants also produce IDP through the methylerythriol pathway (MEP).
The iridioids, molecules used in plants for defensive purposes and in insects as sex pheromones. These molecules are also produced from IDP, and include a cyclization to form the cyclopentanoid pyran scaffold. Plants and insects share the same core enzymatic steps.
Cyanogenic glycosides, molecules used as defense compounds due to their toxicity. The biosynthetic pathway starts with an aliphatic or aromatic amino acids and involves the formation of oximes and α‐hydroxynitriles, followed by stabilization of the cyanohydrin by conjugation to a sugar.
Hypotheses for the origin of the same molecules in both groups are: convergent evolution, sequestration of metabolites, and horizontal gene transfer, driven by parallel needs for defense chemicals. (Summary by Laura Mejia) New Phytol. 10.1111/nph.15718
Tags: Biochemistry, Biotic Interactions, Ecology, Evolution
Signatures of local adaptation in lowland and highland teosintes from whole genome sequencing of pooled samples ($)
Tea genome expansion linked to TE bursts (Plant Biotechnol. J.)
Protein degradation rate in Arabidopsis thaliana leaf growth and development
Increase in monoderm bacteria in drought-delayed early sorghum root microbiomes (PNAS)
Review: Plant sex determination
Review. Xylella fastidiosa: Insights into an emerging plant pathogen ($) (Annu. Rev. Plant Phytopathol.)
Genomic inferences of domestication events are corroborated by written records in Brassica rapa ($)
SNARE proteins in replication vesicle trafficking of turnip mosaic virus ($) (Plant Cell)
Review: Jasmonate signalling in carnivorous plants: Copycat of plant defence... Review: Functional status of xylem through time ($) (Annu Rev Plant Biol)


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Comedian and New Mom Iliza Shlesinger Hilariously Shows the Best Bad Advice New Moms Receive
In an all too relatable new ad from Willow featuring comedian and new mom Iliza Shlesinger, an expectant mom is subjected to unhelpful tips from well-meaning family and friends. The new campaign urges new parents to know that they deserve better.
Photo: Courtesy of Willow
When you're an expectant or new parent, celebrations thrown in your honor, diapers, bottles, and onesies aren't all you'll receive. You're also bound to find yourself swimming in lots and lots of bad, irritating, facepalm-inducing advice and commentary. That's the relatable subject of a new campaign from Willow featuring comedian and new mom Iliza Shlesinger.
In the wearable breast pump maker's new ad, Shlesinger stars as an expectant mom at her baby shower—as well as the mom's college bro, grandmother, mother-in-law, friend who's all about eating the placenta, and other exaggerated characters who offer lame remarks that might actually sound all too familiar to new parents.
The crew shares their many thoughts on everything from the mom-to-be returning to work, napping when the baby naps and eating when the baby eats, breastfeeding in the broom closet, and epidurals being "for losers."
Thankfully, the soon-to-be mom is visited by her cooler, more in-the-know self who tells her, "It doesn't have to be this way. You can pump and live your life," before handing her a Willow pump.
The Best Portable Breast Pumps of 2022
Shlesinger co-created and wrote the spot in an effort to help shed light on the new motherhood experience.
In a press release, the comedian noted, "Pregnancy and parenting are filled with so much well-intentioned advice that doesn't actually support moms. Moms deserve better; they deserve empathy and humor. This ad is all about seeing the world from mom's perspective and bringing some levity to our challenges."
This Is What the Ultimate Office Pumping Room Looks Like & Why It Matters
The ad is tied to the launch of Willow's "Register for More" campaign, which the company says "provides shareable resources for mothers and their circle of supporters created by experts and influential moms." The site currently offers info and advice on work, pumping, and wellness, such as how to demand paid family leave and how your partner can support your mental health.
Sarah O'Leary, chief commercial officer of Willow, tells Parents.com exclusively that following over two years of challenges for new parents, the campaign is about "disrupting the sometimes absurd experiences of parenting culture to create a more hopeful and better path."
"Everything we do at Willow starts with mom," continues O'Leary. "Our mission is to build solutions to moms' most meaningful problems, which, of course, we do through our products, but we also want to be an advocate for moms. We want mom's village to see the world from her perspective and advocate for change, too."
In other words, no expectant or new parent should feel like they just have to "suck it up" and accept the status quo when it's not working for them. As O'Leary sums it up: "Moms deserve better." With hope, campaigns like this one will fuel the kind of conversation and advocacy that ensures they receive better too.
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7 Online Support Groups for Parents During the COVID-19 Pandemic


text:
Symptoms, transmission and treatment
COVID‑19: Medical consultation during the pandemic
Even during the pandemic, you can consult a health or social services professional if you feel the need or if you or a family member has a health problem or a psychosocial problem. Find out about the consultation procedures depending on your situation on the page If you need a consultation during the COVID‑19 pandemic.
Development of symptoms
Modes of transmission
The symptoms of COVID-19 are as follows:
fever:
in children 0-5 years old: 38.5°C (101.3°F) and above (rectal temperature),
in children 6 years and older: 38.1°C (100.6°F) and above (oral temperature),
in adults: 38°C (100.4°F) and above (oral temperature),
in older adults: 37.8°C (100°F) and above (oral temperature),
or 1.1°C above the person's usual value;
general symptoms:
sudden loss of sense of smell without nasal congestion, with or without loss of taste,
major fatigue,
significant loss of appetite,
general muscle pain (not related to physical exertion);
respiratory symptoms:
cough (new or worse),
shortness of breath, difficulty breathing,
sore throat,
runny or stuffy nose;
gastrointestinal symptoms:
diarrhea,
stomach aches.
Symptoms can be mild or more severe like those associated with pneumonia.
Some people can spread the virus without knowing it because they have no symptoms or have not yet developed them.
People most at risk of dying from complications are those:
with a weak immune system;
with a chronic disease such as diabetes or heart, lung and kidney disease;
age 70 and older.
However, the risk of death is highest for people aged 70 and older.
Symptoms develop on average from 5 to 7 days after contamination, but may appear over a 2 to 12 day period of time. To be cautious, at least 14 days of isolation is recommended.
If you believe you have been exposed to COVID-19 or have symptoms similar to COVID-19, you are invited to complete the COVID-19 Symptom Self-Assessment to get a recommendation on the next steps to follow, according to your condition. This assessment can be completed for your child or for another member of your family. However, this tool is not intended to be a substitute for medical attention. People who develop symptoms can also contact 1‑877‑644‑4545. Even if you do not have any symptoms, you could be required to take a screening test in certain situations. For more details, go to the screening test page.
Note that you must self-isolate if you have symptoms of COVID-19. Consult the page When to self-isolate to find out about the different self-isolation directives according to your situation.
COVID‑19 is spread from person to person by contact with droplets projected into the air when a person who is sick talks, coughs or sneezes. It can also be spread by infected hands. This is why it is important to wear a mask. This means that you can contract a coronavirus by touching your mouth, nose or eyes after contact with an infected person or surface. The risks of transmission vary according to the nature of contact between people (JPG 2.53 Mb). While it can be spread by contaminated objects or surfaces, this is not the main mode of transmission.
The exact mode of transmission of COVID‑19 is unknown at this time. However, a person with COVID‑19 is thought to be contagious from 48 hours before their symptoms appear. Studies are ongoing.
In general, coronaviruses do not survive for long on objects. They can survive on surfaces for a few hours to several days. It mainly depends on the type of surface (for example, copper, cardboard, stainless steel, plastic), the temperature and ambient humidity. According to findings from a recent experiment, the virus might be able to survive up to:
4 hours on copper;
24 hours on cardboard;
48 hours (2 days) on stainless steel;
72 hours (3 days) on plastic.
At this time, there is no evidence to suggest that food is a likely source or route of transmission of COVID-19. You should continue to wash fruits and vegetables as usual and to follow good hygiene practices during food preparation.
In Québec, there is no evidence to suggest that people are at risk of contracting COVID‑19 from animals or animal products.
Some viruses in the coronavirus family cause disease in animals, while others cause disease in humans. Coronaviruses that cause disease in humans can be spread by close contact between people. In rare cases, coronaviruses that infect animals can also infect people. Like SARS‑CoV‑2, the virus responsible for COVID‑19, two other coronaviruses are spread from animals to humans and cause or have caused serious disease in humans, namely, SARS‑CoV in 2003 and MERS‑CoV since 2012.
There is no specific treatment or vaccine for COVID-19. Supportive treatment may, however, be provided.
You will find health advice to alleviate the symptoms in the self-care guide.
Most people with COVID-19 will recover on their own.
Answers to questions about Coronavirus (COVID-19)
How to recognize a reliable source of information on health