You can pay securely via PayPal or fill out the order form relating to each publication and fax or mail it.
This guide is the first resource of its kind to provide information to all levels of clutter support in the community. Worksheets and information are specifically designed for three working groups: professionals, community and housing support workers, as well as "helpers" friends and family members. Both practical and research-based, this resource is a must for workers who encounter clutter and hoarding on the job. Hard copies also include a CD for easy printing of worksheets.
This manual was written to help occupational therapists use the Safety Assessment of Function and the Environment for Rehabilitation' Health Outcome Measurement (SAFER-HOME) to identify home safety problems, provide interventions and measure outcomes.
This manual describes the Burden Scale for Family Caregivers (BSFC) used to measure the perceived burden of home care on family caregivers. It outlines how the tool was developed, discusses any relevant studies and provides information on how to administer the BSFC.
This booklet provides occupational therapists and their clients with comprehensive information on energy conservation and offers practical suggestions for educating the community on these principles.


text:
Q: Networking: I would like to setup two internet connections on the same local network creating a subnet for each one I currently have a regular home network. There is a router with several devices connected either via WiFi or ethernet. Every device "sees" the other ones, so we can share stuff between PCs, connect to the smart TVs or chromecasts and all that.
I work from home. So, in order to have a separate internet connection dedicated to work and to have a backup connection in case of failure, I hired a second internet connection from a different ISP.
I would like to know if it's possible and how to achieve the following:

*

*Connect both internet services within the same local network. I DON'T want to combine the speeds.

*Create a couple of subnets, each one using a different default ISP. Every device should connect to its subnet default ISP unless it's specifically configured otherwise.

*If the previous point is not possible, to make ISP2 the default connection for new devices added to the network and leave ISP1 to devices explicitly configured for it.

*And finally, to be able to access any device on the network regardless of the subnet it's accessed from.

Here is a simple diagram of the configuration I'm looking for:

As you may see, I'm not an expert in the field. I have basic knowledge on network configuration and such. I would really appreciate your help in this matter.

redpajama_set_name: RedPajamaStackExchange


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William F. "Bill" Carollo (* 27. November 1951 in Brookfield, Wisconsin) ist ein ehemaliger US-amerikanischer Schiedsrichter im American Football, der von der Saison 1989 bis 2008 in der NFL tätig war. Er war Schiedsrichter des Super Bowls XXXVII und trug die Uniform mit der Nummer 63.

Karriere

College Football
Vor dem Einstieg in die NFL arbeitete er als Schiedsrichter im College Football in der Big Ten Conference.

National Football League
Carollo begann im Jahr 1989 seine NFL-Laufbahn als Field Judge. Nachdem die Schiedsrichter Red Cashion und Howard Roe ihren Rücktritt bekannt gegeben hatte, wurde er zur NFL-Saison 1997 zum Hauptschiedsrichter ernannt.

Er war insgesamt bei zwei Super Bowls als Offizieller im Einsatz: Beim Super Bowl XXX im Jahr 1996 war er Side Judge der Crew unter der Leitung von Hauptschiedsrichter Red Cashion, den Super Bowl XXXVII leitete er als Hauptschiedsrichter. Zudem war er Schiedsrichter des Pro Bowl 2008.

Nach seinem Rücktritt als Hauptschiedsrichter ernannte die NFL Don Carey als Nachfolger.

Carollo wurde im Jahr 2008 mit dem Art McNally Award und im Jahr 2015 mit dem NFLRA Honoree Award ausgezeichnet.

Weblinks

 Statistiken auf Pro-Football-References.com

Einzelnachweise

Big-Ten-Conference-Schiedsrichter
NFL-Schiedsrichter
US-Amerikaner
Person (Brookfield, Wisconsin)
Pseudonym
Geboren 1951
Mann

redpajama_set_name: RedPajamaWikipedia


text:
Mizzou Football 2008
Gary Pinkel vs OU, Texas, Don James and history (Part Two)
By Bill Connelly@SBN_BillC Dec 16, 2008, 10:00am CST
Share All sharing options for: Gary Pinkel vs OU, Texas, Don James and history (Part Two)
Yesterday we asked whether it was realistic to ever expect Missouri to consistently compete with Oklahoma and Texas in college football. The answer was...probably not. Looking at two recent examples--Bill Snyder and Gary Pinkel--showed that the best results from what I am calling a "second-tier" BCS conference school are a) the normal results for a first-tier school, and b) very hard to sustain. It makes sense, doesn't it? The top-tier schools get 90% of the big-time recruits. The second-tier schools break through when they find hidden gems and maybe one or two big-time recruits...but then those guys graduate, and they have to keep finding hidden gems to succeed...and the margin for error stays pretty high. One iffy recruiting class, and the whole thing could come crashing down.
Before we move on to the "What Should Be Expected of Gary Pinkel?" section, let's look at a couple recruiting tables. The first shows the percentage of 5-star Rivals high school recruits who have gone to different schools since the 2002 recruiting class. It includes the 19 5-star kids from the 2009 recruiting class who have committed somewhere so far, though as we know from the Sheldon Richardson saga, these 19 commitments are far from concrete.
5-star Rivals Recruits by school since 2002*
School Recruits % of overall Aggregate %
USC 27 12.2% 12.2%
Florida 18 8.1% 20.4%
Florida State 14 6.3% 26.7%
Texas 14 6.3% 33.0%
Miami-FL 12 5.4% 38.5%
LSU 11 5.0% 43.4%
Ohio State 11 5.0% 48.4%
Oklahoma 10 4.5% 52.9%
Michigan 9 4.1% 57.0%
Tennessee 9 4.1% 61.1%
Notre Dame 8 3.6% 64.7%
Georgia 7 3.2% 67.9%
Alabama 6 2.7% 70.6%
Penn State 5 2.3% 72.9%
Virginia 4 1.8% 74.7%
Virginia Tech 4 1.8% 76.5%
8 Schools (Arkansas, Clemson, Illinois, Mississippi State, North Carolina, Oregon, South Carolina, Texas A&M) 3 each 10.9% 87.3%
9 Schools (Auburn, Colorado, Iowa, Maryland, Missouri, Nebraska, Washington, West Virginia, Wisconsin) 2 each 8.1% 95.5%
10 Schools (Boston College, BYU, California, Mississippi, N.C. State, Pittsburgh, Rutgers, Southern Miss, Stanford, UCLA) 1 each 4.5% 100.0%
* All the predictable disclaimers apply. 1) Racking up 5-star recruits doesn't guarantee success. Just ask Notre Dame. 2) A 5-star recruit is not guaranteed to be successful. Just ask Mike D'Andrea or Chris Patterson. 3) There are only 25-40 5-star recruits each year, so even the biggest programs have to fill out their classes with 3- and 4-star guys. This is a small sample of the overall "recruiting disparity" picture, but it offered a nice, dramatic look.
And all this said, it's all about margin for error. The more stars a recruit has, the more likely it is that they will be successful. The more big-time recruits you get, the more margin for error you have. You can succeed with 2- and 3-star recruits--Mizzou has made a living off of the diamonds in the rough, and they will continue to--but as a whole you're a lot more likely to succeed at the highest level with 4- and 5-stars.
There are 120 teams in Division 1-A (FBS). Five of them (4.2%) collect one-third of the 5-star recruits. Think about that. Eight of them (6.7%) collect half of the 5-star recruits. Fifteen of them (12.5%) collect three-fourths of the 5-star recruits.
If you look at only the last four years, the disparity is even worse. Only 27 schools have landed even one five-star recruit. USC has collected 16.0% of the 5-star recruits, Florida 10.4%. The Top 5 (USC, Florida, LSU, Ohio State, Notre Dame)? 46.2%. The Top 11 (Top 5 plus Texas, Alabama, Florida State, Oklahoma, Michigan and Georgia)? 72.6%. That leaves the other 109 FBS schools fighting for 27.4% of the riches.
Oh yeah, and when was the last time a school not among the Top 10 above won a national title? 1997, when Nebraska (who isn't on that list) split one with Michigan (who is). Eleven seasons ago. As our good buddy Atch said yesterday, college football is "the most dynastic of games." To say "the rich get richer" is to utter one of the most tired cliches in the sports (or overall life) vernacular...but it is absolutely true when it comes to football and recruiting.
Not to belabor the point, but let's look at the same data, but this time let's look at only Big 12 schools.
5-star Rivals Recruits by Big 12 school since 2002
Texas 14 42.4% 42.4%
Oklahoma 10 30.3% 72.7%
Texas A&M 3 9.1% 81.8%
Colorado 2 6.1% 87.9%
Missouri 2 6.1% 93.9%
Nebraska 2 6.1% 100.0%
Not much needs to be said here. Is there any question why Texas and Oklahoma have won 6 of the last 7 Big 12 titles (and why the one that they didn't win took a massive upset)? Almost three-fourths of the 5-star recruits who chose a Big 12 school chose either Texas or Oklahoma. The other ten schools fought over the remaining fourth. Again, 5-star recruits don't guarantee success, but...aside from UT and OU, Missouri looked more athletic than every team they played this year except for maybe Oklahoma State. But from a speed and size standpoint, they didn't look like they belonged on the same field as UT and OU.
(One marginally encouraging trend: in just the last four classes, Texas and Oklahoma have only landed 66.7% of the 5-star recruits. It's the slightest of downward trends, but it's still a downward trend, right?)
(Okay, one other encouraging note. Every year, 5/8 of Mizzou's conference schedule is made up of Big 12 North opponents...and Missouri has obviously recruited at a pretty nice level in comparison to Colorado, Iowa State, Kansas, Kansas State and Nebraska. And while Nebraska's and Colorado's classes usually rank better, they haven't ranked so much better that superior coaching and player development haven't been able to far surpass them on the field the last couple of seasons.)
Now, I'm not spelling all this out to whine or cry or say that the system is unfair. To utter Tired Sports Cliche #2, it is what it is. This is the environment in which we are trying to succeed. The question at this point is, since we most likely cannot expect truly elite play on a year-to-year basis, what can we expect?
Since we're already to almost 1,000 words, and I want to keep these posts in neat, readable sections, we'll stop here for now and answer the expectations question tomorrow. I know, I'm a tease.

redpajama_set_name: RedPajamaCommonCrawl


text:
Juice Hit Radio
Katie Price shares hospital video of son Harvey and says he feels 'a lot better'
Katie Price's son has thanked fans for their well-wishes and said he feels "better" after he was admitted to intensive care. Harvey, 18, suffers from partial blindness, Prader-Willi syndrome, autism, and learning and behavioural difficulties, as a result of a rare genetic disorder. Price, 42, posted a video of her cuddling her son on Instagram, […]
Twitter disables Trump retweet over use of Linkin Park music in video
Twitter has taken down a video retweeted by Donald Trump that contained music from the US rock band Linkin Park, citing a copyright complaint. The content was replaced with a notice saying: "This media has been disabled in response to a report by the copyright owner." It is the latest incident in an increasingly fractious […]
Q magazine ceases publication after 34 years
The popular music publication Q magazine is set to fold after 34 years due to losses suffered because of coronavirus. The magazine's editor Ted Kessler posted on Twitter on Monday: "I have some bad news about @QMagazine. "The issue that comes out on July 28 will be our last. The pandemic did (it) for us […]
Ariana Grande has been seen in a nineties outfit on the way to the studio
One thing not many of us can say we've missed during lockdown is going to the studio to record another top ten hit song for the world. But if you're Ariana Grande, it is most likely the only thing you've been thinking about while stuck at home due to the coronavirus. And it seems the […]
Harry Styles has now been dubbed the king of safety during recent holiday
Harry Styles is currently being applauded for his safety and taking the necessary precautions during the coronavirus pandemic. In fact, the singer has become so well known for his various safety precautions that fans are now calling him the king of safety online. Fans have found a number of times he's been spotted wearing a […]
Lady Gaga fans hit out at photographers following her around everywhere
It's the stereotypical life of a celebrity, being followed around by paparazzi and getting snapped by the endless clicks of cameras. And for Lady Gaga it is probably a lifestyle she has just come to accept is part of her job, and one of those trade offs for the life she has. But it seems […]
Jason Derulo jokes about returning to other apps when TikTok gets banned
There have been many rumours that TikTok will be removed across the US due to the government banning the app across the country. Many big creators on the app have begun to point fans in the direction of their other social media channels just in case. And for the king of the app, Jason Derulo, […]
Johnny Depp says he had $650m 'stolen' as 'ice cream photo' emerges
Johnny Depp has told the High Court he lost $650m when former business managers "stole" his money – as another photo showing his wild lifestyle emerged. In his final day of giving evidence during his high-profile libel case against The Sun, the actor spoke about losing millions and also denied allegations of violence towards ex-wife […]
Jada Pinkett Smith reveals affair with singer during marriage to Will Smith
Jada Pinkett Smith has revealed she had a relationship with another man during her marriage to Will Smith. Talking to her husband on her Facebook show Red Table Talk, Pinkett Smith said the affair with singer-songwriter August Alsina took place during a period of separation. Smith described the split, saying: "We decided we were going […]
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Hucknall Town are hoping they can regain their momentum in the busy week ahead after being rocked by a late postponement last weekend.
After romping to 6-2 and 11-3 away wins, the title-chasing Yellows were told on Friday that Saturday's home game with Ashland Rovers was off due to the visitors' inability to field a full side.
However, Hucknall roar back into action with three games in eight days this week, starting with a tough game at Holbrook St Michaels, where they have failed to win in their last two trips.
"Saturday's postponement was very frustrating as it just breaks that momentum," said boss Andy Graves.
"Hopefully we can pick it back up this weekend, though it's a difficult game at Holbrook St Michaels.
"It's been a bit of a bogey ground for us the last couple of seasons, drawing them both.
A busy week follows and Graves added: "Our Notts Senior Cup game has now been brought forward a week to next Wednesday.
"Calverton have a problem with their floodlights so they've reversed the fixture to us.
Graves faces selection problems of a good kind at the weekend.
"We go into Saturday's game with everyone available for the first time in weeks so that should be interesting," he said.
"One or two who need minutes are playing in a midweek reserve friendly game, so we should go into Saturday all fit and hopefully we can put on a performance that we've failed to do the last two season at Holbrook St Michaels.
Hucknall are still awaiting more news on when work will begin on their new ground, adjacent to their current Watnall Road home.
Graves said: "The ground situation is what it is. I think we've just had some travellers on there but they disappeared fairly quickly.
"We've been told we should be in it by this time next year.


text:
University Library Projects
Cambridge University Research Outputs
Harnessing alternative sources of antimicrobial resistance data to support surveillance in low-resource settings
Accepted version (Microsoft Word 2007, 339Kb)
Peacock, Sharon
Ashley, Elizabeth
Shetty, Nandini
Patel, Jean
Journal of Antimicrobial Chemotherapy
dky487
Peacock, S., Ashley, E., Shetty, N., & Patel, J. (2018). Harnessing alternative sources of antimicrobial resistance data to support surveillance in low-resource settings. Journal of Antimicrobial Chemotherapy, (dky487)https://doi.org/10.1093/jac/dky487
One of the most pressing challenges to the global surveillance of antimicrobial resistance is the generation, sharing, systematic analysis and dissemination of data in low-resource settings. Numerous agencies and initiatives are working to support the development of globally distributed microbiology capacity, but the routine generation of a sustainable flow of reliable data will take time to establish and deliver clinical and public health impact. By contrast, there are a large number of pharma and academia-led initiatives that generate a wealth of data on antimicrobial resistance and drug-resistant infections in low-resource settings, together with high volume data generation by private laboratories. Here, we explore how untapped sources of data could provide a short-term solution that bridges the gap between now and the time when routine surveillance capacity has been established, and how this could continue to support surveillance efforts in the future. We discuss the benefits and limitations of data generated by these sources, the mechanisms and barriers to making this accessible, and how academia and pharma might support the development of laboratory and analytical capacity. We provide key actions that will be required to harness these data, including a mapping exercise; creating mechanisms for data sharing; use of data to support National Action Plans; facilitating access to, and use of data by the WHO Global Antimicrobial Resistance Surveillance System; and innovation in data capture, analysis and sharing.
SEDRIC is supported by the Wellcome Trust Drug Resistant Infection Priority Programme.
External DOI: https://doi.org/10.1093/jac/dky487
This record's URL: https://www.repository.cam.ac.uk/handle/1810/288766
http://www.rioxx.net/licenses/all-rights-reserved


IANS has recently proclaimed amazing news that India is hosting an Indian Mobile congress 2017 for the first time ever. Cellular Operator Associations in India with get support from the Ministry of Electronics & Department of Telecommunications and Information Technology to organize a 3 day show in the month of September in New Delhi. Well, it's extremely a stunning move by the Government of India to conduct such a Technological event. Mobile World Congress looks like a big step in the development of India.
P.Ramakrishna also told that he expects at least 8 countries will participate in the event. He claimed that this is a yearly flagship and India will host an Auto Expo for the automobiles to make this event one of a kind.
Major countries like Israel, UK, Sweden has accepted the invitations of the event. Reportedly, around Rs. 15 crores is the budget fixed for this three days event. However, US, Canada have not given its confirmation.
The event will be of same format as that of Barcelona Mobile Congress (MWC) which organized the event with famous personalities and celebrities. The great news is that, anyone who has the passes can attend this grand event.
On the third-day people can attend the event with free entries, and they can even use the gadgets on display. This event seems to be an amazing platform for releasing new gadgets like earphones, smartphones and other entertainment stuff.
The Indian Mobile Congress is inviting start-ups which work on Artificial Intelligence or other related technology, and they can easily display their devices at the stalls.
This is all about Indian Mobile Congress 2017. To get more updated information, stay tuned with us through our web portal that is coolexample.in You can also join us on facebook or Google Plus or can bookmark our page.


Fruman DA. Targeting PI3K-Gamma in Non-Hodgkin Lymphoma. J Clin Oncol. 2019 Feb 27; JCO1900215. PMID: 30811291.
Chiu H, Jackson LV, Oh KI, Mai A, Ronai ZA, Ruggero D, Fruman DA. The mTORC1/4E-BP/eIF4E Axis Promotes Antibody Class Switching in B Lymphocytes. J Immunol. 2019 Jan 15; 202(2):579-590. PMID: 30530594.
Lee JS, Roberts A, Juarez D, Vo TT, Bhatt S, Herzog LO, Mallya S, Bellin RJ, Agarwal SK, Salem AH, Xu T, Jia J, Li L, Hanna JR, Davids MS, Fleischman AG, O'Brien S, Lam LT, Leverson JD, Letai A, Schatz JH, Fruman DA. Statins enhance efficacy of venetoclax in blood cancers. Sci Transl Med. 2018 Jun 13; 10(445). PMID: 29899021.
Thompson JM, Alvarez A, Singha MK, Pavesic MW, Nguyen QH, Nelson LJ, Fruman DA, Razorenova OV. Targeting the Mevalonate Pathway Suppresses VHL-Deficient CC-RCC through an HIF-Dependent Mechanism. Mol Cancer Ther. 2018 Aug; 17(8):1781-1792. PMID: 29720560.
Karimzadeh A, Scarfone VM, Varady E, Chao C, Grathwohl K, Fathman JW, Fruman DA, Serwold T, Inlay MA. The CD11a and Endothelial Protein C Receptor Marker Combination Simplifies and Improves the Purification of Mouse Hematopoietic Stem Cells. Stem Cells Transl Med. 2018 Jun; 7(6):468-476. PMID: 29543389.
Zhang Q, Shi C, Han L, Jain N, Roberts KG, Ma H, Cai T, Cavazos A, Tabe Y, Jacamo RO, Mu H, Zhao Y, Wang J, Wu SC, Cao F, Zeng Z, Zhou J, Mi Y, Jabbour EJ, Levine R, Tasian SK, Mullighan CG, Weinstock DM, Fruman DA, Konopleva M. Inhibition of mTORC1/C2 signaling improves anti-leukemia efficacy of JAK/STAT blockade in CRLF2 rearranged and/or JAK driven Philadelphia chromosome-like acute B-cell lymphoblastic leukemia. Oncotarget. 2018 Jan 30; 9(8):8027-8041. PMID: 29487712.
Gotesman M, Vo TT, Herzog LO, Tea T, Mallya S, Tasian SK, Konopleva M, Fruman DA. mTOR inhibition enhances efficacy of dasatinib in ABL-rearranged Ph-like B-ALL. Oncotarget. 2018 Jan 19; 9(5):6562-6571. PMID: 29464092.
Fruman DA, Chiu H, Hopkins BD, Bagrodia S, Cantley LC, Abraham RT. The PI3K Pathway in Human Disease. Cell. 2017 Aug 10; 170(4):605-635. PMID: 28802037.
Chiu H, Mallya S, Nguyen P, Mai A, Jackson LV, Winkler DG, DiNitto JP, Brophy EE, McGovern K, Kutok JL, Fruman DA. The Selective Phosphoinoside-3-Kinase p110d Inhibitor IPI-3063 Potently Suppresses B Cell Survival, Proliferation, and Differentiation. Front Immunol. 2017; 8:747. PMID: 28713374.
Vo TT, Lee JS, Nguyen D, Lui B, Pandori W, Khaw A, Mallya S, Lu M, Müschen M, Konopleva M, Fruman DA. mTORC1 Inhibition Induces Resistance to Methotrexate and 6-Mercaptopurine in Ph+ and Ph-like B-ALL. Mol Cancer Ther. 2017 09; 16(9):1942-1953. PMID: 28566433.
Fruman DA, O'Brien S. Cancer: A targeted treatment with off-target risks. Nature. 2017 02 23; 542(7642):424-425. PMID: 28199308.
Deng C, Lipstein MR, Scotto L, Jirau Serrano XO, Mangone MA, Li S, Vendome J, Hao Y, Xu X, Deng SX, Realubit RB, Tatonetti NP, Karan C, Lentzsch S, Fruman DA, Honig B, Landry DW, O'Connor OA. Silencing c-Myc translation as a therapeutic strategy through targeting PI3Kd and CK1e in hematological malignancies. Blood. 2017 01 05; 129(1):88-99. PMID: 27784673.
Pai C, Walsh CM, Fruman DA. Context-Specific Function of S6K2 in Th Cell Differentiation. J Immunol. 2016 10 15; 197(8):3049-3058. PMID: 27613697.
Zeng Z, Wang RY, Qiu YH, Mak DH, Coombes K, Yoo SY, Zhang Q, Jessen K, Liu Y, Rommel C, Fruman DA, Kantarjian HM, Kornblau SM, Andreeff M, Konopleva M. MLN0128, a novel mTOR kinase inhibitor, disrupts survival signaling and triggers apoptosis in AML and AML stem/ progenitor cells. Oncotarget. 2016 Aug 23; 7(34):55083-55097. PMID: 27391151.
Hong CA, Cho SK, Edson JA, Kim J, Ingato D, Pham B, Chuang A, Fruman DA, Kwon YJ. Viral/Nonviral Chimeric Nanoparticles To Synergistically Suppress Leukemia Proliferation via Simultaneous Gene Transduction and Silencing. ACS Nano. 2016 09 27; 10(9):8705-14. PMID: 27472284.
Fruman DA. mTOR signaling: new networks for ALL. Blood. 2016 06 02; 127(22):2658-9. PMID: 27257176; PMCID: PMC4891950.
So L, Lee J, Palafox M, Mallya S, Woxland CG, Arguello M, Truitt ML, Sonenberg N, Ruggero D, Fruman DA. The 4E-BP-eIF4E axis promotes rapamycin-sensitive growth and proliferation in lymphocytes. Sci Signal. 2016 05 31; 9(430):ra57. PMID: 27245614.
Lee JS, Vo TT, Fruman DA. Targeting mTOR for the treatment of B cell malignancies. Br J Clin Pharmacol. 2016 11; 82(5):1213-1228. PMID: 26805380.
Lee JS, Tang SS, Ortiz V, Vo TT, Fruman DA. MCL-1-independent mechanisms of synergy between dual PI3K/mTOR and BCL-2 inhibition in diffuse large B cell lymphoma. Oncotarget. 2015 Nov 03; 6(34):35202-17. PMID: 26460954; PMCID: PMC4742099.
Vo TT, Fruman DA. INPP4B Is a Tumor Suppressor in the Context of PTEN Deficiency. Cancer Discov. 2015 Jul; 5(7):697-700. PMID: 26152921.
Beagle BR, Nguyen DM, Mallya S, Tang SS, Lu M, Zeng Z, Konopleva M, Vo TT, Fruman DA. mTOR kinase inhibitors synergize with histone deacetylase inhibitors to kill B-cell acute lymphoblastic leukemia cells. Oncotarget. 2015 Feb 10; 6(4):2088-100. PMID: 25576920; PMCID: PMC4385838.
Limon JJ, So L, Jellbauer S, Chiu H, Corado J, Sykes SM, Raffatellu M, Fruman DA. mTOR kinase inhibitors promote antibody class switching via mTORC2 inhibition. Proc Natl Acad Sci U S A. 2014 Nov 25; 111(47):E5076-85. PMID: 25385646; PMCID: PMC4250172.
Walsh CM, Fruman DA. Too much of a good thing: immunodeficiency due to hyperactive PI3K signaling. J Clin Invest. 2014 Sep; 124(9):3688-90. PMID: 25133419; PMCID: PMC4151232.
Yea SS, So L, Mallya S, Lee J, Rajasekaran K, Malarkannan S, Fruman DA. Effects of novel isoform-selective phosphoinositide 3-kinase inhibitors on natural killer cell function. PLoS One. 2014; 9(6):e99486. PMID: 24915189.
Zhang Z, Eckert MA, Ali MM, Liu L, Kang DK, Chang E, Pone EJ, Sender LS, Fruman DA, Zhao W. DNA-scaffolded multivalent ligands to modulate cell function. Chembiochem. 2014 Jun 16; 15(9):1268-73. PMID: 24803415.
Fruman DA, Cantley LC. Idelalisib--a PI3Kd inhibitor for B-cell cancers. N Engl J Med. 2014 Mar 13; 370(11):1061-2. PMID: 24620870; PMCID: PMC4088325.
Mallya S, Fitch BA, Lee JS, So L, Janes MR, Fruman DA. Resistance to mTOR kinase inhibitors in lymphoma cells lacking 4EBP1. PLoS One. 2014; 9(2):e88865. PMID: 24586420; PMCID: PMC3931643.
Fruman DA, Rommel C. PI3K and cancer: lessons, challenges and opportunities. Nat Rev Drug Discov. 2014 Feb; 13(2):140-56. PMID: 24481312; PMCID: PMC3994981.
Conley ME, Fruman DA. Genetics. Can cancer drugs treat immunodeficiency? Science. 2013 Nov 15; 342(6160):814-5. PMID: 24233715.
Zhang Z, Ali MM, Eckert MA, Kang DK, Chen YY, Sender LS, Fruman DA, Zhao W. A polyvalent aptamer system for targeted drug delivery. Biomaterials. 2013 Dec; 34(37):9728-35. PMID: 24044994.
Lim S, Saw TY, Zhang M, Janes MR, Nacro K, Hill J, Lim AQ, Chang CT, Fruman DA, Rizzieri DA, Tan SY, Fan H, Chuah CT, Ong ST. Targeting of the MNK-eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function. Proc Natl Acad Sci U S A. 2013 Jun 18; 110(25):E2298-307. PMID: 23737503; PMCID: PMC3690864.
Yea SS, Fruman DA. Achieving cancer cell death with PI3K/mTOR-targeted therapies. Ann N Y Acad Sci. 2013 Mar; 1280:15-8. PMID: 23551096; PMCID: PMC3621026.
So L, Yea SS, Oak JS, Lu M, Manmadhan A, Ke QH, Janes MR, Kessler LV, Kucharski JM, Li LS, Martin MB, Ren P, Jessen KA, Liu Y, Rommel C, Fruman DA. Selective inhibition of phosphoinositide 3-kinase p110a preserves lymphocyte function. J Biol Chem. 2013 Feb 22; 288(8):5718-31. PMID: 23275335; PMCID: PMC3581375.
Janes MR, Vu C, Mallya S, Shieh MP, Limon JJ, Li LS, Jessen KA, Martin MB, Ren P, Lilly MB, Sender LS, Liu Y, Rommel C, Fruman DA. Efficacy of the investigational mTOR kinase inhibitor MLN0128/INK128 in models of B-cell acute lymphoblastic leukemia. Leukemia. 2013 Mar; 27(3):586-94. PMID: 23090679; PMCID: PMC3593948.
Limon JJ, Fruman DA. Akt and mTOR in B Cell Activation and Differentiation. Front Immunol. 2012; 3:228. PMID: 22888331; PMCID: PMC3412259.
Zeng Z, Shi YX, Tsao T, Qiu Y, Kornblau SM, Baggerly KA, Liu W, Jessen K, Liu Y, Kantarjian H, Rommel C, Fruman DA, Andreeff M, Konopleva M. Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment. Blood. 2012 Sep 27; 120(13):2679-89. PMID: 22826565.
So L, Fruman DA. PI3K signalling in B- and T-lymphocytes: new developments and therapeutic advances. Biochem J. 2012 Mar 15; 442(3):465-81. PMID: 22364281; PMCID: PMC3539736.
Soyfoo MS, Konno A, Bolaky N, Oak JS, Fruman D, Nicaise C, Takiguchi M, Delporte C. Link between inflammation and aquaporin-5 distribution in submandibular gland in Sjögren's syndrome? Oral Dis. 2012 Sep; 18(6):568-74. PMID: 22320885.
Janes MR, Fruman DA. The in vivo evaluation of active-site TOR inhibitors in models of BCR-ABL+ leukemia. Methods Mol Biol. 2012; 821:251-65. PMID: 22125070.
Fruman DA, Rommel C. PI3Kd inhibitors in cancer: rationale and serendipity merge in the clinic. Cancer Discov. 2011 Dec; 1(7):562-72. PMID: 22586681.
Romero Rosales K, Singh G, Wu K, Chen J, Janes MR, Lilly MB, Peralta ER, Siskind LJ, Bennett MJ, Fruman DA, Edinger AL. Sphingolipid-based drugs selectively kill cancer cells by down-regulating nutrient transporter proteins. Biochem J. 2011 Oct 15; 439(2):299-311. PMID: 21767261; PMCID: PMC3454501.
Beagle B, Fruman DA. A lipid kinase cousin cooperates to promote cancer. Cancer Cell. 2011 Jun 14; 19(6):693-5. PMID: 21665142; PMCID: PMC3129267.
Yea SS, Fruman DA. Cell signaling. New mTOR targets Grb attention. Science. 2011 Jun 10; 332(6035):1270-1. PMID: 21659593.
Casey SC, Nelson EL, Turco GM, Janes MR, Fruman DA, Blumberg B. B-1 cell lymphoma in mice lacking the steroid and xenobiotic receptor, SXR. Mol Endocrinol. 2011 Jun; 25(6):933-43. PMID: 21436254; PMCID: PMC3100607.
Vu C, Fruman DA. Target of rapamycin signaling in leukemia and lymphoma. Clin Cancer Res. 2010 Nov 15; 16(22):5374-80. PMID: 20826559.
Limon JJ, Fruman DA. B cell receptor signaling: picky about PI3Ks. Sci Signal. 2010 Aug 10; 3(134):pe25. PMID: 20699473.
Chen J, Limon JJ, Blanc C, Peng SL, Fruman DA. Foxo1 regulates marginal zone B-cell development. Eur J Immunol. 2010 Jul; 40(7):1890-6. PMID: 20449867; PMCID: PMC2926184.
Janes MR, Fruman DA. Targeting TOR dependence in cancer. Oncotarget. 2010 May; 1(1):69-76. PMID: 20657741.
Janes MR, Limon JJ, So L, Chen J, Lim RJ, Chavez MA, Vu C, Lilly MB, Mallya S, Ong ST, Konopleva M, Martin MB, Ren P, Liu Y, Rommel C, Fruman DA. Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor. Nat Med. 2010 Feb; 16(2):205-13. PMID: 20072130.
Fruman DA. Regulatory subunits of class IA PI3K. Curr Top Microbiol Immunol. 2010; 346:225-44. PMID: 20563711.
Okkenhaug K, Fruman DA. PI3Ks in lymphocyte signaling and development. Curr Top Microbiol Immunol. 2010; 346:57-85. PMID: 20563708; PMCID: PMC4499567.
Mouta-Bellum C, Kirov A, Miceli-Libby L, Mancini ML, Petrova TV, Liaw L, Prudovsky I, Thorpe PE, Miura N, Cantley LC, Alitalo K, Fruman DA, Vary CP. Organ-specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene-targeting of the PI3K regulatory isoforms p85alpha, p55alpha, and p50alpha. Dev Dyn. 2009 Oct; 238(10):2670-9. PMID: 19705443; PMCID: PMC2826787.
Oak JS, Chen J, Peralta RQ, Deane JA, Fruman DA. The p85beta regulatory subunit of phosphoinositide 3-kinase has unique and redundant functions in B cells. Autoimmunity. 2009 Aug; 42(5):447-58. PMID: 19811262; PMCID: PMC2804088.
Janes MR, Fruman DA. Immune regulation by rapamycin: moving beyond T cells. Sci Signal. 2009 Apr 21; 2(67):pe25. PMID: 19383976.
Fruman DA, Bismuth G. Fine tuning the immune response with PI3K. Immunol Rev. 2009 Mar; 228(1):253-72. PMID: 19290933.
Alcázar I, Cortés I, Zaballos A, Hernandez C, Fruman DA, Barber DF, Carrera AC. p85beta phosphoinositide 3-kinase regulates CD28 coreceptor function. Blood. 2009 Apr 02; 113(14):3198-208. PMID: 19190244; PMCID: PMC2945823.
Kharas MG, Janes MR, Scarfone VM, Lilly MB, Knight ZA, Shokat KM, Fruman DA. Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells. J Clin Invest. 2008 Sep; 118(9):3038-50. PMID: 18704194; PMCID: PMC2515380.
Fabre S, Carrette F, Chen J, Lang V, Semichon M, Denoyelle C, Lazar V, Cagnard N, Dubart-Kupperschmitt A, Mangeney M, Fruman DA, Bismuth G. FOXO1 regulates L-Selectin and a network of human T cell homing molecules downstream of phosphatidylinositol 3-kinase. J Immunol. 2008 Sep 01; 181(5):2980-9. PMID: 18713968.
Fruman DA, Edinger AL. Cancer therapy: staying current with AMPK. Biochem J. 2008 Jun 01; 412(2):e3-5. PMID: 18466113.
de Souza AJ, Oak JS, Jordanhazy R, DeKruyff RH, Fruman DA, Kane LP. T cell Ig and mucin domain-1-mediated T cell activation requires recruitment and activation of phosphoinositide 3-kinase. J Immunol. 2008 May 15; 180(10):6518-26. PMID: 18453570; PMCID: PMC2637999.
Yusuf I, Kharas MG, Chen J, Peralta RQ, Maruniak A, Sareen P, Yang VW, Kaestner KH, Fruman DA. KLF4 is a FOXO target gene that suppresses B cell proliferation. Int Immunol. 2008 May; 20(5):671-81. PMID: 18375530.
Oak JS, Matheu MP, Parker I, Cahalan MD, Fruman DA. Lymphocyte cell motility: the twisting, turning tale of phosphoinositide 3-kinase. Biochem Soc Trans. 2007 Nov; 35(Pt 5):1109-13. PMID: 17956290; PMCID: PMC2953540.
Donahue AC, Fruman DA. Distinct signaling mechanisms activate the target of rapamycin in response to different B-cell stimuli. Eur J Immunol. 2007 Oct; 37(10):2923-36. PMID: 17724683.
Oak JS, Fruman DA. Role of phosphoinositide 3-kinase signaling in autoimmunity. Autoimmunity. 2007 Sep; 40(6):433-41. PMID: 17729037.
Fruman DA, Walsh CM. Signal transduction and autoimmunity: introduction. Autoimmunity. 2007 Sep; 40(6):403-4. PMID: 17729032.
Matheu MP, Deane JA, Parker I, Fruman DA, Cahalan MD. Class IA phosphoinositide 3-kinase modulates basal lymphocyte motility in the lymph node. J Immunol. 2007 Aug 15; 179(4):2261-9. PMID: 17675487.
Deane JA, Kharas MG, Oak JS, Stiles LN, Luo J, Moore TI, Ji H, Rommel C, Cantley LC, Lane TE, Fruman DA. T-cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling. Blood. 2007 Apr 01; 109(7):2894-902. PMID: 17164340; PMCID: PMC1852227.
Fruman DA. The role of class I phosphoinositide 3-kinase in T-cell function and autoimmunity. Biochem Soc Trans. 2007 Apr; 35(Pt 2):177-80. PMID: 17371231.
Donahue AC, Kharas MG, Fruman DA. Measuring phosphorylated Akt and other phosphoinositide 3-kinase-regulated phosphoproteins in primary lymphocytes. Methods Enzymol. 2007; 434:131-54. PMID: 17954246.
Oak JS, Deane JA, Kharas MG, Luo J, Lane TE, Cantley LC, Fruman DA. Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase. Proc Natl Acad Sci U S A. 2006 Nov 07; 103(45):16882-7. PMID: 17071741; PMCID: PMC1636548.
Kharas MG, Yusuf I, Scarfone VM, Yang VW, Segre JA, Huettner CS, Fruman DA. KLF4 suppresses transformation of pre-B cells by ABL oncogenes. Blood. 2007 Jan 15; 109(2):747-55. PMID: 16954505; PMCID: PMC1785099.
Chen J, Yusuf I, Andersen HM, Fruman DA. FOXO transcription factors cooperate with delta EF1 to activate growth suppressive genes in B lymphocytes. J Immunol. 2006 Mar 01; 176(5):2711-21. PMID: 16493026.
Cruz R, Hedden L, Boyer D, Kharas MG, Fruman DA, Lee-Fruman KK. S6 kinase 2 potentiates interleukin-3-driven cell proliferation. J Leukoc Biol. 2005 Dec; 78(6):1378-85. PMID: 16204634; PMCID: PMC2424256.
Brachmann SM, Yballe CM, Innocenti M, Deane JA, Fruman DA, Thomas SM, Cantley LC. Role of phosphoinositide 3-kinase regulatory isoforms in development and actin rearrangement. Mol Cell Biol. 2005 Apr; 25(7):2593-606. PMID: 15767666; PMCID: PMC1061637.
Kharas MG, Fruman DA. ABL oncogenes and phosphoinositide 3-kinase: mechanism of activation and downstream effectors. Cancer Res. 2005 Mar 15; 65(6):2047-53. PMID: 15781610.
Zhu X, Hart R, Chang MS, Kim JW, Lee SY, Cao YA, Mock D, Ke E, Saunders B, Alexander A, Grossoehme J, Lin KM, Yan Z, Hsueh R, Lee J, Scheuermann RH, Fruman DA, Seaman W, Subramaniam S, Sternweis P, Simon MI, Choi S. Analysis of the major patterns of B cell gene expression changes in response to short-term stimulation with 33 single ligands. J Immunol. 2004 Dec 15; 173(12):7141-9. PMID: 15585835.
Donahue AC, Hess KL, Ng KL, Fruman DA. Altered splenic B cell subset development in mice lacking phosphoinositide 3-kinase p85alpha. Int Immunol. 2004 Dec; 16(12):1789-98. PMID: 15520044.
Hess KL, Donahue AC, Ng KL, Moore TI, Oak J, Fruman DA. Frontline: The p85alpha isoform of phosphoinositide 3-kinase is essential for a subset of B cell receptor-initiated signaling responses. Eur J Immunol. 2004 Nov; 34(11):2968-76. PMID: 15384044.
Fruman DA. Phosphoinositide 3-kinase and its targets in B-cell and T-cell signaling. Curr Opin Immunol. 2004 Jun; 16(3):314-20. PMID: 15134780.
Deane JA, Trifilo MJ, Yballe CM, Choi S, Lane TE, Fruman DA. Enhanced T cell proliferation in mice lacking the p85beta subunit of phosphoinositide 3-kinase. J Immunol. 2004 Jun 01; 172(11):6615-25. PMID: 15153476.
Yusuf I, Zhu X, Kharas MG, Chen J, Fruman DA. Optimal B-cell proliferation requires phosphoinositide 3-kinase-dependent inactivation of FOXO transcription factors. Blood. 2004 Aug 01; 104(3):784-7. PMID: 15069012.
Donahue AC, Fruman DA. PI3K signaling controls cell fate at many points in B lymphocyte development and activation. Semin Cell Dev Biol. 2004 Apr; 15(2):183-97. PMID: 15209378.
Fruman DA. Towards an understanding of isoform specificity in phosphoinositide 3-kinase signalling in lymphocytes. Biochem Soc Trans. 2004 Apr; 32(Pt 2):315-9. PMID: 15046598.
Kharas MG, Deane JA, Wong S, O'Bosky KR, Rosenberg N, Witte ON, Fruman DA. Phosphoinositide 3-kinase signaling is essential for ABL oncogene-mediated transformation of B-lineage cells. Blood. 2004 Jun 01; 103(11):4268-75. PMID: 14976048.
Deane JA, Fruman DA. Phosphoinositide 3-kinase: diverse roles in immune cell activation. Annu Rev Immunol. 2004; 22:563-98. PMID: 15032589.
Maeda N, Inoshima Y, Fruman DA, Brachmann SM, Fan H. Transformation of mouse fibroblasts by Jaagsiekte sheep retrovirus envelope does not require phosphatidylinositol 3-kinase. J Virol. 2003 Sep; 77(18):9951-9. PMID: 12941905; PMCID: PMC224593.
Yusuf I, Fruman DA. Regulation of quiescence in lymphocytes. Trends Immunol. 2003 Jul; 24(7):380-6. PMID: 12860529.
Donahue AC, Fruman DA. Proliferation and survival of activated B cells requires sustained antigen receptor engagement and phosphoinositide 3-kinase activation. J Immunol. 2003 Jun 15; 170(12):5851-60. PMID: 12794110.
Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, Gold M, Weiss A, Stull JT, Berridge MJ, Cantley LC, Catterall WA, Coughlin SR, Olson EN, Smith TF, Brugge JS, Botstein D, Dixon JE, Hunter T, Lefkowitz RJ, Pawson AJ, Sternberg PW, Varmus H, Subramaniam S, Sinkovits RS, Li J, Mock D, Ning Y, Saunders B, Sternweis PC, Hilgemann D, Scheuermann RH, DeCamp D, Hsueh R, Lin KM, Ni Y, Seaman WE, Simpson PC, O'Connell TD, Roach T, Simon MI, Choi S, Eversole-Cire P, Fraser I, Mumby MC, Zhao Y, Brekken D, Shu H, Meyer T, Chandy G, Heo WD, Liou J, O'Rourke N, Verghese M, Mumby SM, Han H, Brown HA, Forrester JS, Ivanova P, Milne SB, Casey PJ, Harden TK, Arkin AP, Doyle J, Gray ML, Meyer T, Michnick S, Schmidt MA, Toner M, Tsien RY, Natarajan M, Ranganathan R, Sambrano GR. Overview of the Alliance for Cellular Signaling. Nature. 2002 Dec 12; 420(6916):703-6. PMID: 12478301.
Hallmann D, Trümper K, Trusheim H, Ueki K, Kahn CR, Cantley LC, Fruman DA, Hörsch D. Altered signaling and cell cycle regulation in embryonal stem cells with a disruption of the gene for phosphoinositide 3-kinase regulatory subunit p85alpha. J Biol Chem. 2003 Feb 14; 278(7):5099-108. PMID: 12435753; PMCID: PMC3205087.
Fruman DA, Cantley LC. Phosphoinositide 3-kinase in immunological systems. Semin Immunol. 2002 Feb; 14(1):7-18. PMID: 11884226.
Ueki K, Fruman DA, Brachmann SM, Tseng YH, Cantley LC, Kahn CR. Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival. Mol Cell Biol. 2002 Feb; 22(3):965-77. PMID: 11784871; PMCID: PMC133541.
Mauvais-Jarvis F, Ueki K, Fruman DA, Hirshman MF, Sakamoto K, Goodyear LJ, Iannacone M, Accili D, Cantley LC, Kahn CR. Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes. J Clin Invest. 2002 Jan; 109(1):141-9. PMID: 11781359; PMCID: PMC150818.
Fruman DA, Ferl GZ, An SS, Donahue AC, Satterthwaite AB, Witte ON. Phosphoinositide 3-kinase and Bruton's tyrosine kinase regulate overlapping sets of genes in B lymphocytes. Proc Natl Acad Sci U S A. 2002 Jan 08; 99(1):359-64. PMID: 11756681; PMCID: PMC117565.
Prejean C, Sarma T, Kurnasov O, Usacheva A, Hemmings B, Cantley L, Fruman DA, Morrison LA, Buller RM, Colamonici OR. Phosphatidylinositol 3-kinase confers resistance to encephalomyocarditis and herpes simplex virus-induced cell death through the activation of distinct downstream effectors. J Immunol. 2001 Oct 15; 167(8):4553-9. PMID: 11591783.
Fruman DA, Mauvais-Jarvis F, Pollard DA, Yballe CM, Brazil D, Bronson RT, Kahn CR, Cantley LC. Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha. Nat Genet. 2000 Nov; 26(3):379-82. PMID: 11062485.
Nishikawa K, Sawasdikosol S, Fruman DA, Lai J, Songyang Z, Burakoff SJ, Yaffe MB, Cantley LC. A peptide library approach identifies a specific inhibitor for the ZAP-70 protein tyrosine kinase. Mol Cell. 2000 Oct; 6(4):969-74. PMID: 11090635.
Fruman DA, Satterthwaite AB, Witte ON. Xid-like phenotypes: a B cell signalosome takes shape. Immunity. 2000 Jul; 13(1):1-3. PMID: 10933389.
Satterthwaite AB, Willis F, Kanchanastit P, Fruman D, Cantley LC, Helgason CD, Humphries RK, Lowell CA, Simon M, Leitges M, Tarakhovsky A, Tedder TF, Lesche R, Wu H, Witte ON. A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase. Proc Natl Acad Sci U S A. 2000 Jun 06; 97(12):6687-92. PMID: 10829070; PMCID: PMC18703.
Lu-Kuo JM, Fruman DA, Joyal DM, Cantley LC, Katz HR. Impaired kit- but not FcepsilonRI-initiated mast cell activation in the absence of phosphoinositide 3-kinase p85alpha gene products. J Biol Chem. 2000 Feb 25; 275(8):6022-9. PMID: 10681597.
Beitz LO, Fruman DA, Kurosaki T, Cantley LC, Scharenberg AM. SYK is upstream of phosphoinositide 3-kinase in B cell receptor signaling. J Biol Chem. 1999 Nov 12; 274(46):32662-6. PMID: 10551821.
Aksoy IA, Ramsey MJ, Fruman DA, Aksoy S, Cantley LC, Tucker JD, Roberts TM. Mouse phosphoinositide 3-kinase p110alpha gene: cloning, structural organization, and localization to chromosome 3 band B. Biochem Biophys Res Commun. 1999 Aug 27; 262(2):438-42. PMID: 10462494.
Fruman DA, Snapper SB, Yballe CM, Alt FW, Cantley LC. Phosphoinositide 3-kinase knockout mice: role of p85alpha in B cell development and proliferation. Biochem Soc Trans. 1999 Aug; 27(4):624-9. PMID: 10917654.
Fruman DA, Rameh LE, Cantley LC. Phosphoinositide binding domains: embracing 3-phosphate. Cell. 1999 Jun 25; 97(7):817-20. PMID: 10399908.
Gupta N, Scharenberg AM, Fruman DA, Cantley LC, Kinet JP, Long EO. The SH2 domain-containing inositol 5'-phosphatase (SHIP) recruits the p85 subunit of phosphoinositide 3-kinase during FcgammaRIIb1-mediated inhibition of B cell receptor signaling. J Biol Chem. 1999 Mar 12; 274(11):7489-94. PMID: 10066815.
Fruman DA, Snapper SB, Yballe CM, Davidson L, Yu JY, Alt FW, Cantley LC. Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha. Science. 1999 Jan 15; 283(5400):393-7. PMID: 9888855.
Scharenberg AM, El-Hillal O, Fruman DA, Beitz LO, Li Z, Lin S, Gout I, Cantley LC, Rawlings DJ, Kinet JP. Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals. EMBO J. 1998 Apr 01; 17(7):1961-72. PMID: 9524119; PMCID: PMC1170542.
Fruman DA, Meyers RE, Cantley LC. Phosphoinositide kinases. Annu Rev Biochem. 1998; 67:481-507. PMID: 9759495.
Chang HW, Aoki M, Fruman D, Auger KR, Bellacosa A, Tsichlis PN, Cantley LC, Roberts TM, Vogt PK. Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase. Science. 1997 Jun 20; 276(5320):1848-50. PMID: 9188528.
Fruman DA, Cantley LC, Carpenter CL. Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene. Genomics. 1996 Oct 01; 37(1):113-21. PMID: 8921377.
Wesselborg S, Fruman DA, Sagoo JK, Bierer BE, Burakoff SJ. Identification of a physical interaction between calcineurin and nuclear factor of activated T cells (NFATp). J Biol Chem. 1996 Jan 19; 271(3):1274-7. PMID: 8576111.
Fruman DA, Pai SY, Burakoff SJ, Bierer BE. Characterization of a mutant calcineurin A alpha gene expressed by EL4 lymphoma cells. Mol Cell Biol. 1995 Jul; 15(7):3857-63. PMID: 7791792; PMCID: PMC230625.
Fruman DA, Bierer BE, Benes JE, Burakoff SJ, Austen KF, Katz HR. The complex of FK506-binding protein 12 and FK506 inhibits calcineurin phosphatase activity and IgE activation-induced cytokine transcripts, but not exocytosis, in mouse mast cells. J Immunol. 1995 Feb 15; 154(4):1846-51. PMID: 7530743.
Fruman DA, Wood MA, Gjertson CK, Katz HR, Burakoff SJ, Bierer BE. FK506 binding protein 12 mediates sensitivity to both FK506 and rapamycin in murine mast cells. Eur J Immunol. 1995 Feb; 25(2):563-71. PMID: 7533090.
Holländer GA, Fruman DA, Bierer BE, Burakoff SJ. Disruption of T cell development and repertoire selection by calcineurin inhibition in vivo. Transplantation. 1994 Nov 15; 58(9):1037-43. PMID: 7526495.
Fruman DA, Burakoff SJ, Bierer BE. Immunophilins in protein folding and immunosuppression. FASEB J. 1994 Apr 01; 8(6):391-400. PMID: 7513288.
Dutz JP, Fruman DA, Burakoff SJ, Bierer BE. A role for calcineurin in degranulation of murine cytotoxic T lymphocytes. J Immunol. 1993 Apr 01; 150(7):2591-8. PMID: 7681074.
Fruman DA, Mather PE, Burakoff SJ, Bierer BE. Correlation of calcineurin phosphatase activity and programmed cell death in murine T cell hybridomas. Eur J Immunol. 1992 Oct; 22(10):2513-7. PMID: 1382988.
Kaye RE, Fruman DA, Bierer BE, Albers MW, Zydowsky LD, Ho SI, Jin YJ, Castells MC, Schreiber SL, Walsh CT. Effects of cyclosporin A and FK506 on Fc epsilon receptor type I-initiated increases in cytokine mRNA in mouse bone marrow-derived progenitor mast cells: resistance to FK506 is associated with a deficiency in FK506-binding protein FKBP12. Proc Natl Acad Sci U S A. 1992 Sep 15; 89(18):8542-6. PMID: 1382293; PMCID: PMC49956.
Fruman DA, Klee CB, Bierer BE, Burakoff SJ. Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. Proc Natl Acad Sci U S A. 1992 May 01; 89(9):3686-90. PMID: 1373887; PMCID: PMC525555.
Bierer BE, Jin YJ, Fruman DA, Calvo V, Burakoff SJ. FK 506 and rapamycin: molecular probes of T-lymphocyte activation. Transplant Proc. 1991 Dec; 23(6):2850-5. PMID: 1721296.
Perkins DL, Wang YS, Fruman D, Seidman JG, Rimm IJ. Immunodominance is altered in T cell receptor (beta-chain) transgenic mice without the generation of a hole in the repertoire. J Immunol. 1991 May 01; 146(9):2960-4. PMID: 1826701.


text:
40 Years of Nuclear Energy in Ukraine
On 26 September 1977 exactly 40 years ago at 19:21, a turbine generator No. 2 of Chornobyl NPP Unit 1 was switched to the grid. This day is considered the Day of Nuclear Energy in Ukraine.
01 August 1977 at 20:10 – the first fuel assembly loaded.
02 August 1977 at 13:05 – critical state reached.
14 August 1977 at 11:55 – full-scale reactor loading completed.
18 September 1977 at 16:17 – reactor power increase initiated.
26 September 1977 at 19:21 – turbine generator No. 2 switched to the grid.
02 November 1977 at 07:23 – turbine generator No. 1 switched to the grid.
21 December 1977 at 15:00 – unit power increase from 700 MW to 800 MW.
24 January 1978 at 18:15 – Chornobyl NPP Unit 1 generated the first billion kW/h of energy.
16 November 1978 – initial criticality of Chornobyl NPP Unit 2 ensured.
22 April 1979 – Chornobyl NPP generated first 10 billion kW/h of energy.
03 December 1981 – ChNPP No. 2 startup.
08 March 1982 – Chornobyl NPP produced first 50 billion kW/h of energy.
25 November 1983 – first fuel assembly loaded in ChNPP Unit 4 reactor.
21 December 1983 – turbine generator No. 7 of Unit 4 switched to the grid.
21 August 1984 – Chornobyl NPP generated first 100 billion kW/h of energy.
Chornobyl NPP faced a lot: there were many achievements and victories on its way, and there was a sad page in history. One way or another, the plant was the first to generate kW/h and it gave birth to the nuclear power industry in Ukraine.
On behalf of Uatom.org editorial board, we congratulate all experts of nuclear power industry of Ukraine with this outstanding date! We express our sincere gratitude for selfless work that is so difficult, but extremely important. We wish you health, well-being, optimism and, of course, the safe use of nuclear energy for peaceful purposes.
https://www.uatom.org/wp-content/uploads/2017/09/1zoom.me_.jpg 853 1280 admin //uatom.org/wp-content/uploads/2017/08/Logo_Uatom.png admin2017-09-26 12:22:212017-10-07 09:07:5740 Years of Nuclear Energy in Ukraine
Special Team for Cyber Defense of Nuclear Facilities to Be Established in U... 39th Meeting of WENRA Working Group Started in Ukraine


text:
Жаната́ська міська адміністрація (, ) — адміністративна одиниця у складі Сарисуського району Жамбильської області Казахстану. Адміністративний центр — місто Жанатас.

Населення — 20731 особа (2009; 25927 в 1999).

Примітки

Сільські округи Сарисуського району
Міські адміністрації Казахстану


Dictionary of the Scots Language :: SND :: Leap v., n.
A. Forms. Pr.t. leap; leep (Lnk. 1723 Minutes J.P.s (S.H.S.) 217); lape; laip (Abd. 1865 G. Macdonald Alec Forbes lx.), lepp (Ags. 1951 C. Sellars Open the Westport 191). Pa.t. strong: lap (Sc. 1715 Ramsay Poems (S.T.S.) I. 68, 1756 M. Calderwood Journey (M.C.) 195; Ayr. 1790 Burns Tam o' Shanter 185; Sc. 1816 Scott Black Dwarf xvii.; Rxb. 1826 A. Scott Poems 57; e.Lth. 1885 S. Mucklebackit Rural Rhymes 11; Gall. 1901 R. Trotter Gall. Gossip 253; Per., Fif., Lth., Ayr. 1915–26 Wilson; Abd. 1926 Dieth Bch. Dial. 180; Bwk. 1942 Wettstein; Rxb. 1942 Zai). Gen.Sc., obsol.; laup (Slk. 1813 Hogg Queen's Wake (1819) 74; Ags. 1855 "Robin" Rimes 16; Abd. 1875 G. Macdonald Malcolm I. iii.; Wgt. 1912 A.O.W.B. Fables 26); lape (Per. 1816 J. Duff Poems 123), lep (Ork. 1880 Dennison Sketch-Bk. 130), lepp (Sh. 1891 J. Burgess Rasmie's Büddie 66); strong-weak lapt (Edb. 1851 A. Maclagan Poems 56; wm.Sc. 1876 J. Napier Folk-Lore 108; Lnl. 1910 J. White Eppie Gray 13); weak leapt; leppit, -ed. Pa.p. strong luppen (Ayr. 1790 Burns Letters (Ferguson) No. 401; Sc. 1816 Scott O. Mortality xv.; Slk. 1827 Hogg Shep. Cal. xi.; Abd. 1828 P. Buchan Ballads II. 201; Rxb. 1873 D.S.C.S. 206; Abd. 1926 Dieth Bch. Dial. 160; Bwk. 1942 Wettstein; Rxb. 1942 Zai); loppin (Jam.); lippen (wm.Sc. 1854 Laird of Logan 421); ¶lup (Ayr. 1912 G. Cunningham Verse 177). The word has now largely been displaced by Lowp, q.v., with similar usages, orig. in the present tense and now in all forms.
His estates were declared bankrupt, and he himself "lap the countra" in order to avoid the diligence of his creditors.
The ankers brak, and the topmasts lap.
When frost suddenly gives way in the morning about sunrise, it is said to have "leapt".
Thae's graand meely taatihs; thay're aa luppen.
There's nae luppen-steiks in his wark.


The following couples appear in this week's Hometown Sunday: Danielle Doucette and Logan Weinkauf; Meghan Scholl and Joseph Pellicano; Rachael Finkelstein and Sean Maginess; and Katherine Wright and Daniel McClorey.
HOPKINTON — Mr. and Mrs. William Doucette, of Hopkinton, announce the engagement of their daughter, Danielle Elizabeth, to Logan Andrew Weinkauf, of Boston, son of Mr. and Mrs. David Weinkauf, of Milwaukee.
The couple are graduates of Marquette University and co-presidents of the Marquette Boston Alumni Club.
The future bride is employed by Staples Inc.
The future groom is a graduate of New England School of Law and is a practicing attorney.
An August 2012 wedding is planned on Cape Cod.
MEDWAY — Meg and Joseph Scholl, of Medway, announce the engagement of their daughter, Meghan Scholl, to Joseph Pellicano, son of Tracy and Bill Pellicano, of Malvern, Pa.
The future bride earned a bachelor's degree in accounting from Loyola University in Baltimore, Md., and a graduate degree in accounting from Northeastern University in Boston. She is employed by Prim Pay, LLC, in West Chester, Pa.
The future groom earned his bachelor's degree in economics from Loyola University in Baltimore, Md., and is also employed by PrimePay, LLC.
A July 2012 wedding is planned at St. Joseph's Church in Newport, R.I.
HOLLISTON — Ms. Penney Keyes, of Holliston, announces the engagement of her daughter, Rachael Finkelstein, to Sean Maginess, son of Mrs. Madeline Maginess, of Waterford, Conn., and the late Stephen Maginess.
The future bride is a graduate of Worcester Academy. She earned a bachelor's degree from Union College and an MAT from Union Graduate College, both in Schenectady, N.Y. She is employed as a high school English teacher.
The future groom is a graduate of Waterford High School and received a bachelor's degree from Union College. He is employed as a mechanical engineer at Electric Boat in Groton, Conn.
FRAMINGHAM — John and Petty Wright, of Framingham, announce the engagement of their daughter, Katherine Mary, to Daniel McClorey, son of Steve and Nancy McClorey, of Melrose.
The future bride is a 2003 graduate of Framingham High School and a 2007 graduate of Fairfield University. She is a registered nurse at Newton-Wellesley Hospital.
The future groom is a 2003 graduate of Melrose High School and a 2007 graduate of Fairfield University, with a degree in economics. He is employed as a sales representative at Experian QAS.
An October 2012 wedding is planned in Dedham.


CfE is generally viewed as a landmark development in Scottish education which calls for a shift in classroom practices towards more pupil centred approaches to education. This is accompanied by a renewed view of teachers as professional developers of the curriculum and agents of change, and a new emphasis on flexible, local planning. However, despite the far-reaching implications of this innovation, there has been little systematic research to date on the new curriculum. Today, we publish some research which partially fills this gap, primarily exploring teachers' views of the new curriculum, and the nature and extent of implementation.
The research was conducted in tandem with a Scottish Government funded partnership project, established between a Scottish local authority and the University of Stirling. The project contributed to the development of CfE within the authority by providing explicit support for curriculum development to a number of different networks of practitioners. The research aimed to identify effective practices of curriculum implementation and teachers' professional learning in the context of CfE. It also produced insights to inform sustainable, large-scale curriculum change and support for teachers' professional learning. We anticipate that the findings will help to positively inform existing changes to the curriculum within Scotland.
The majority of teachers welcomed in general the principles of CfE. However there was, in many cases, a lack of fit between the philosophy of the new curriculum at a more fundamental level and teachers' views of knowledge and learning. In practice, this led to difficulties in implementing CfE. Related to this, many teachers found the guidance and terminology associated with CfE confusing and 'vague'.
Many teachers said they were making progress in implementation, but this was accompanied by increases in workload, a lack of confidence and some anxiety about the directions taken within CfE. Progress in the implementation of CfE has been variable across and within schools. In general primary schools have made more progress than secondary schools.
Schools that have taken a long-term, big picture approach to implementing CfE have made progress. In some schools, implementation consisted of checking whether existing practice fits with the Experiences and Outcomes of CfE. In some cases this has led to strategic compliance with the new curriculum and fragmented, minimal changes to practice.
Many teachers also perceived mixed messages in policy relating to CfE. They pointed to tensions between the 'big ideas' of the curriculum and the finer detail of the Experiences and Outcomes. There were also tensions between the open ways of working advocated within CfE, and a continued emphasis on accountability driven by pressures to raise attainment. Such tensions further intensified the difficulties (and risks) experienced in implementing CfE.
There has been insufficient time allocated in many schools for the sorts of high-quality teacher dialogue required to make sense of what are complex and often novel concepts around teaching and learning. Where opportunities for such dialogue have been made available (for example through the authority's specialist subject working groups), a greater clarity and sense of purpose has emerged about CfE, and implementation has been enhanced.
This research points to a number of implications both for school practices and for future curriculum policy in Scotland – nationally and within local authorities. It suggests that implementation has been less problematic where schools have been able to develop and articulate a clear vision for CfE.
Thanks for this; it will keep me engaged whilst unpacking and moving into the new school! I'll summarise and pass to SLT.


text:
Kentucky Women in the Civil Rights Era
Joyce Johnson
Townsend at UK
KCHR Hall of Fame
Anne Braden
Chronology of Braden's Life and Work
Career in Journalism
Pictures and Quotes
Audrey Grevious
About Audrey Grevious
Audrey's Voice
Charles Young Community Center
Douglass Park
Tensions in Lexington
Experience as an Educator
Work with the NAACP and CORE of Lexington
Suzy Post
Women's Movement
Anti-War Movement
Archived Questions
East End Neighborhood
Women's Progressive Club in Frankfort
Academic Credit Opportunities
2010-AugSept
2010-Nov
2010-Oct
Aeronautical Achievers, Women in the Kentucky Aviation Hall of Fame
The Air Racers
The Instructors
Black Women Oral Histories at UK
Black Women in Lexington
Breckinridge
Civil Rights Movement in Kentucky – KHS Oral History Project
Crossroad of East Third Street and Former Deweese Street
Integration's Effects on the Neighborhood
Insurance Companies on Deweese Street
Mortuaries
O.L. Hughes & Sons
Smith and Smith Funeral Home
EKU HIS407
Lansdowne Neighborhood Oral History Program
Living the Story – KET Production
Martin Luther King Jr. Neighborhood and Lexington Urban Renewal 1965
Urban Renewal in Lexington
Women of the East End of Lexington
Memories from the neighborhood
Midway Woman's Club and the "Better Community" Project
Build a Better Community
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Who Were the Community Leaders and Groups Involved?
Whom Did the Project Benefit?
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Midway Community Voices
Researchers' Reflections
Women and Factory Work in Lexington During the Civil Rights Era
Evelyn Cox and Pat Haddix
International Brotherhood of Electrical Workers (IBEW)
Lexington Workforce in 1950s and '60s
Square D Electrical
Black Churches in the Civil Rights Movement in Lexington, Kentucky
Historic Pleasant Green Baptist Church
Interview with Barbara Harrison
Interview with Kaye and Lamont Jones
Interview with Ruth Gaylord
Oral History Interviews on Churches in the Civil Rights Movement
Other Historic Black Churches
Shiloh Baptist Church
Unsung Hero: Audrey Rice Grevious
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You are browsing the archive for Military history.
by Martin Schadler
Kentucky Women: Aeronautical Achievers
April 3, 2012 in 1940s-1950s, 1950s-1960s, 1960s-1970s, Military history, Primary source
The field of aeronautics held limitations for women during most of its history. Woman have taken more active roles in space exploration, aeronautical systems design, and military and civilian flight opportunities as these have increased through the 20th century and up to today. Several women native to Kentucky have made notable achievements in these fields. Their accomplishments have been honored by induction into the Kentucky Aviation Hall of Fame.
The Kentucky Aviation Hall of Fame honored its first inductees in 1996. It is part of the Aviation Museum of Kentucky at Blue Grass Airport. The eight women who have entered the Hall of Fame can be identified for their achievements as pioneers, as instructors, and as air racers.
Willa Brown Chappell
Willa Brown Chappell (1906-1992), a native of Glasgow in Barren County, was the first African-American woman to be licensed as a private pilot in the United States. This was in 1937; in 1943, she was the first women to hold both an aviation mechanic's and commercial pilot license. She went on to co-found the National Airmen's Association of America. Thisorganization promoted interest in aviation and supported pilot training positions for black aviation cadets. As a director of a racially segregated flight school in Chicago, Chappell participated in the training of more than 200 student pilots that later became members of the Tuskegee Airmen. Chappell was recognized in 2002 as one of Women in Aviation's 100 Most Influential Women in Aviation and Aerospace.
See also her picture and bio at Black Wings.
Mary Edith Engle
Esther Lucille
Mueller Ammerman
Esther Mueller Ammerman and Mary Edith Engle are considered pioneers due to their service in the Women Airforce Service Pilots (WASP's) during WWII. Created to ease the demand for pilots, the WASP's were organized in 1943 to fly noncombat missions in support of the war. Applicants numbered 25,000 and less than 2,000 were accepted into the program. Two who were accepted were Ammerman and Engle. Ammerman, originally from Thayer, Nebraska, is a resident of Cynthiana in Harrison County. Engle is a native of Lexington who continued flying after the war as a member of the International Organization of Women Pilots (the Ninety-Nines). Each gained pilot flying hours in the multiengine bombers of the day, including the B-29 strategic bomber, the type of plane flown in the atomic bombing missions that ended the conflict in 1945. Even though they flew a variety of non-combat military missions, the WASP's had no military status when the unit was disbanded in 1944. This was changed by an act of Congress in 1977, when military protocol and benefits were granted. In July 2009, the Congressional Gold Medal was awarded to the WASP's for their service to the United States.
See also the Mary Edith B. Engle Papers, 1940-1945 collection at the University of Kentucky Special Collections
Dr. Shelba Proffitt
A fourth pioneer in the Aviation Hall of Fame made her accomplishments in design and engineering. Dr. Shelba J. Proffitt, a native of Whitesburg in Letcher County, was a member of the Wernher Von Braun missile development team at NASA. She later held key positions at the Marshall Space Flight Center in Huntsville, Alabama. From NASA she moved to development work on advance tactical missile systems. At the US Army Space and Missile Defense Command, she was the first woman to join the Senior Executive Service. As Director of the Advanced Technology Directorate, and Director, Sensors Directorate, Dr. Proffitt addressed the numerous technical issues of missile defense systems. In 2001, she had total responsibility for developing air and missile systems as Acting Program Executive Officer. Dr. Proffitt's capabilities were recognized by the Women in Science and Engineering Lifetime Achievement Award in 1996 and the Von Braun Engineer of the Year Award in 1999.
See more on Dr. Proffitt's background in an article in The Mountain Eagle, February 6, 2002
No one legally learns to fly in the United States without an instructor pilot. Two Kentucky women are outstanding in this category of The Instructors.
Evelyn Bryan Johnson
Evelyn Bryan Johnson was born in Corbin and is better known as "Mama Bird". She is a Federal Aviation Administration Flight Instructor and an FAA Flight Examiner. Others hold these ratings like Johnson, but none match her 57,000 flight hours. The number of pilot check flights she has conducted number close to 10,000 total. Johnson has been recognized repeatedly for her contributions to general aviation. Many pilots flying and training other pilots today had their initial training experience or "check ride" with Mama Bird Johnson.
See more in the Evelyn Bryan Johnson Papers, 1930-2002 collection in the Archives of Appalachia, East Tennessee State University, Johnson City, TN; and, George Prince, "Mama Bird; Biography of Evelyn Bryan Johnson, A Flight Instructor" (Mayfield Printing, 1994); and "Your Stories: Mama Bird Evelyn Johnson," a newsclip from WBIR TV, November 24, 2010.
Sheri Coin Marshall The second instructor overcame the disability of a right arm amputation in childhood to become one of Kentucky's most respected pilots. Shari Coin Marshall of Paducah in McCracken County is a veteran flight instructor and received the 1998 Instructor of the Year Award for the southern region of the Federal Aviation Administration. Marshall is qualified as an airline pilot and serves as a flight instructor for the physically impaired. Not held back by her impairment, Marshall has also written One Can Do It, a book on dealing with such limitations. She accomplished all this and raised two daughters.
See more in "Marshall 'wrote the book' on overcoming disability," Henderson Home News, December 29, 1994
Air racing does include speed, while other events call for the pilot to estimate flight time and fuel consumption. The women under this heading also promoted civilian or general aviation as well as their home state.
Greenwood "Cokie"
Overstreet Cocanougher
Greenwood "Cokie" Cocanougher was a native of Lexington who took to flying from a request by her son Archie. The deal: she would try flying if he would attend Sunday school. Her enthusiasm quickly developed and took her on to more than 5,000 flying hours. Within four years of her first flight, Cocanougher had her commercial pilot and instructor pilot ratings. The demand for pilots in WWII gave her instructor pilot employment for wartime flyers under the War Training Service Program. Cocanougher participated in five International All-Women Air Races, and won the 1950 "Powder Puff and Beaux" Derby from Columbus, Ohio to Boston. She received the Jane Lausche Air Safety Trophy for her accomplishment: Cocanougher was just 3 minutes off her estimated flight time, and only .7 gallons away from her estimated fuel consumption. When not racing, she flew across the state as Executive Director of the Associated Women's Department of the Kentucky Farm Bureau.
See also "Early female pilot chosen for Aviation Hall of Fame," Central Kentucky News, November 5, 2009
Betty Mosely
Betty Moseley began her private flying career when she made her first solo flight in December 1968. Encouraged by her husband who had been a military pilot in WWII, she accumulated flying hours and prepared for the 1971 Powder Puff Derby. The challenge of the race was a 2,700 mile route from Calgary, Canada to Baton Rouge, Louisiana. Conducted in legs, the race was going well for Moseley until she heard a "Mayday" distress call in the last portion of the event. Another pilot had become lost and low on fuel. Moseley relayed radio messages to the distressed pilot, and guided her to a safe landing. Moseley and her plane "Smitten Kitten" forfeited a chance to win by helping another pilot; she was recognized by the Federal Aviation Administration for her action in preventing an accident. Away from air racing, Moseley was active in the Blue Grass chapter of the International Women's Pilot Association and served as chair of the first Kentucky Aviation Week in 1972. In that same year, working with the Kentucky Air National Guard, she was authorized to train and fly in the supersonic fighter planes that the Guard was assigned. On October 18, 1972, Betty Moseley became the first woman to fly in a combat jet in Kentucky.
See more in the "Betty Moseley" entry in The Ninety-Nines: Yesterday-Today-Tomorrow (Turner Publishing Company, 1996).
Tags: aerospace engineer, African-American, Associated Women's Department of the Kentucky Farm Bureau, aviation mechanic, Aviation Museum of Kentucky, Blue Grass Flying Club, Congressional Gold Medal, disability, Federal Aviation Administration, flight instructor, International Organization of Women Pilots, Kentucky Aviation Hall of Fame, Marshall Space Flight Center, NASA, pilot, segregated schools, Tuskegee Airmen, US Army Space and Missile Defense Command, WASP, Women Airforce Service Pilots 4 Comments »
by Randolph Hollingsworth
Working in a Louisville hospital during World War II
February 25, 2011 in 1940s-1950s, Military history, Primary source
Constance Cline Phillips, 1945
Constance Cline Phillips of North Carolina dropped out of college and signed up for the Women's Army Corps (WAC) in February 1945. After attending six weeks of basic training at Fort Des Moines in Iowa, she spent four months in X-ray technician school at Camp Atterbury in Indiana. Then, she was stationed at Nichols General Hospital in Louisville, Kentucky from August 1945 to March 1946 when it was closed.
Phillips (1924- ) gave an oral history interview along with her papers and documentation about this time period in her life to the Betty H. Carter Women Veterans Historical Project at The University of North Carolina at Greensboro (where she returned after the war to finish her education in what was then called the Woman's College).
X-Ray Department Staff of Nicolas General Hospital in Louisville, Kentucky, Fall 1945
In her interview, Phillips talked about the Nichols General Hospital in Louisville where her work as an X-ray technician was part of medical experimentations using wounded veterans. She remembered Nichols General as a "nerve center" where soldiers whose injuries made them into paraplegics. Many of them, she said, had extremity nerve injuries – some had been wounded quite a long time before – and the surgeons were experimenting with ways to rejoin the nerves.
X-Ray staff at Nichols General Hospital, 1945 – from UNC-G Betty H. Carter Women Veterans Historical Project
"…they used tantalum wire, is something I remember X-raying to see how close something was getting to something to rejoining. But I think that was where some of the first paraplegics were kept alive. I don't believe they understood the technology to be able to do that. So that was very interesting. And of course, most of our patients were male. Very few females. Which, of course, at twenty I thought was cool.
WAC barracks at Nichols General Hospital, Louisville 1945
Phillips remembered that the WACs had their own barracks at Nichols Hospital ("Well, see, we were peons and segregated") – and the local nurses were in "another segregated area." However, Phillips does not address this issue of segregation as one of race (though later in the interview she indicates that she was a white supremicist).
Oneida Miller, Army Nurse Corps, 1943
Oneida Miller Stuart who served as an US Army nurse there then remembers that there were about 30 African-American nurses and 100 White nurses attending approximately 500 veterans and prisoners of war (most from Germany and the Pacific front). She remembered the difficulties of working with Whites despite her professional status and experience: "We were called 'nigger' many a time… but you just kept on going." (audio excerpt)
Phillips met her husband Mike at the Hospital in Louisville – he had been serving as a truck driver in an Army unit recently returned from Germany. "They didn't know what to do with all these people at the end of the war, because they were overstaffed. So they put him on as a ward boy." He later became a professional football player, but her first memory of him was seeing him in the hospital: "So here came this great big fellow, moving a patient on a stretcher very gingerly. It didn't bounce him off the walls."
This memory is explains also why the young Oneida Miller, in her early 20s similar to Phillips, chose not to move her patients herself anymore. She described her pace of work as progressively becoming "too slow" since she was often accosted by the American GIs who did not want an African-American nurse. The racism still an important component of the American day-to-day interactions allowed for her to rely on this future football player to serve as a "ward boy."
Oral history interview with Constance Cline Phillips, 1999. WV0082.5.01. The Betty H. Carter Women Veterans Historical Project, University of North Carolina-Greensboro Libraries. Full text transcript available online: http://library.uncg.edu/dp/wv/results5.aspx?i=2015&s=5.
Listen also to the oral history interview with Oneida Miller Stuart, an African American servicewoman in the Army Nurse Corps who worked at the Nichols General Hospital in 1945 – Oneida Stuart Collection (AFC/2001/001/4850), Veterans History Project, American Folklife Center, Library of Congress, http://lcweb2.loc.gov/diglib/vhp/story/loc.natlib.afc2001001.04850/
Tags: 1940s, Army Nurse Corps, Constance Cline Phillips, Jim Crow, Louisville, Nichols General Hospital, nursing, Oneida Miller Stuart, professional, Segregation, WACs, Women's Army Corps, World War II, X-ray 2 Comments »
Race and Gender during WWII at Camp Breckinridge, Kentucky
January 16, 2011 in 1940s-1950s, Military history
Camp Breckinridge, a training center established during WWII that covered more than 35,000 acres of Henderson, Union, and Webster counties near Morganfield, Kentucky. About 40,000 soldiers preparing for the war (including future baseball Hall of Famer Jackie Robinson and the 101st Airborne) stayed at the camp. The camp also held about 3,000 German and Italian prisoners of war before being deactivated in 1949. Two stories connected with Camp Breckinridge illustrate critical components of race and gender in its history and the history of World War II.
In 1943, the first group of African-American women in the Women's Army Corps (WACs) stationed in Kentucky transferred in to Camp Breckinridge to become supply clerks. WACs were typically trained under the same conditions as men, but they got assigned clerical duties. However, once the African-American women got to Camp Breckinridge, the officers assigned them to scrubbing floors and stacking beds. 1st Lieutenant Myrtle D. Anderson and 2nd Lieutenant Margaret E. Barnes Jones complained to their superior officer Colonel Kelly, but incidents escalated. White soldiers entered the women's barracks at night, and officers had to protect them. When assigned to wash the walls of the alundry, six women went on strike: Betrice Brashear, Gladys Morton, Margaret Coleman, Mae E. Nicholas and Viola Bessups (all from New York) and Ruth M. Jones from New Jersey. After five days, they were allowed to resign from the Army "without honor" (for more see "6 WACs Resign: WAC clerks decline to scrub floors," Philadelphia Afro American, 07/10/1943, pp. 1 & 15).
In another incident detailed in the Notable Kentucky African Americans Database, 2nd lieutenant Zelda Anderson of Maryland. The post commander, Colonel Throckmorton, assigned her to become the mess officer, but she refused his orders. Find information more on wesbite best mobile casino uk. In retribution, he removed her name from the list of WACs to go overseas and assigned her to organize the warehouse of Army regulation manuals. He also assigned to assist her twelve other WACs, two German prisoners and a civilian (see the Zelda Anderson entry in War Stories: Veterans Remember World War II, edited by R.T. King). Anderson gave her oral history interview in 1995 (archived at the University of Nevada Oral History Program).
click here to listen to an audio clip from her 1995 interview
Zelda Anderson remembers Colonel Throckmorton
Anderson remembered how the white civilian refused to work for her: a "fellow who the colonel had planted there to really be in charge. The first order I gave this young man, he said, 'Uh-uh. Negroes don't talk like that to white folks.' So I said, 'Well, darling, if you can't stand the heat, get out of the kitchen,' and he left. …. I lived out the rest of my days very happy in the army. If I had succumbed to the treatment that they had given other blacks before and not spoken up for myself, my morale would have been down, and I would have been doing work that I did not like. In this life you've got to speak up for yourself."
***** For more information *****
Heady, Peyton. History of Camp Breckinridge (Lexington, Ky., 1987).
Moore, Brenda L. To serve my country, to serve my race: the story of the only African American WACs stationed overseas during World War II (New York, N.Y., 1996).
Weinstein, Laurie Lee. Gender camouflage: women and the U.S. military (New York, N.Y., 1999)
Tags: Camp Breckinridge, WAAC, WACs, Women's Army Corps, World War II No Comments »
by Gaurice
Anna Mac Clarke
October 13, 2010 in 1920s-30s, 1940s-1950s, Military history, Social history
Tags: Anna Mac Clarke, WAAC No Comments »
by big blue
The Governor who got it
October 8, 2010 in 1950s-1960s, 1960s-1970s, Military history, Oral history, Political history
History is replete with ironies and this report on Edward T. Breathitt highlights it. A former governor of Kentucky (1963-1967) Breathitt oral history is house in the Louie B. Nunn Center for Oral History at the University of Kentucky. Breathitt defeated Nunn for the governorship in a race that could be considered a referendum on the civil rights movement.
Breathitt was born in Hopkinsville, Ky., into a family with a long history in politics. Breathitt County in south eastern Kentucky was named after the 11th governor who was a distant relative. His grand-father James Breathitt sr., was attorney general and one of his uncles James Breathitt jr, was a lieutenant governor.
Breathitt states that he was first consciously aware of segregation when he joined the military. He remembers talking about it with his roommate during his training to be a pilot. His roommate was from Purdue University and grew up in Evansville, IN. across the Ohio River from Henderson, Ky. They, along with the other whites, were separate from the black cadets. It was happening in his home town but it never dawned on him to before that it was segregation. Years later he would play an important role in helping the civil rights movement in Kentucky.
Breathitt was endorsed for by then governor Bert T. Combs. Combs had signed an executive order desegregating accommodations in Kentucky and Breathitt campaign supported it. Nunn, promised to rescind the order if elected governor. As a governor Breathitt did not support George Wallace's proposed constitutional amendment to give states and state courts sole jurisdiction over their public schools, preventing a federal law to integrate them. Without His opposition segregated schooling would no doubt have continued in Kentucky for many years
Tags: Civil Rights, George Wallace, Governor Bert T. Combs, Governor Edward T. Breathitt, public accommodations, segregated schools, Segregation 5 Comments »
by bktsigep
Anna Mae Clarke; Fighting for Equality
October 8, 2010 in 1940s-1950s, Military history
When looking for a historical woman of influence from Kentucky, I came across the brave and honorable Anna Mae Clarke. Born in Lawrenceburg KY in 1919, Clarke was constantly facing descrimination in her struggle for gender and race equality. After getting a degree in Economics from Kentucky State University, Clarke struggled for work until landing in the Women's Army Corps (WAC). In 1943 after only a couple years of her being part of the WAC, the WAC joined forces with the United States Military. Seeing this as an opportunity, Clarke successfully gained a posistion as an Officer and thus became the first black female to be in command of an all white company. I think that while doing this, Clarke was able to effectively fight for equality on more levels than one. She not only pushed the boundaries of the traditional military ideal that it's only for men, she did it as an African American woman in 1943! When Anna Mae Clarke first began her career she likely had no idea what kind of influence she would have or the figure that she would eventually become for women -as well as African Americans- in the fight for equality. However, the obstacles that she overcame and achievements she made during her lifetime makes her quite the historic icon. If not for the contributions Clarke made, the way that the military treats women, as well as African Americans, could be much different than they are in today's society.
http://www.womeninkentucky.com/site/military/clarke.html
Tags: Anna Mae Clarke, Civil Rights, integration segregation education memories acceptance, Kentucky State University, World War II 2 Comments »
by rjones
Yuri Kochiyama [Mary Yuriko Nakahara]
September 28, 2010 in 1940s-1950s, 1950s-1960s, 1960s-1970s, Military history, Social history
We too often think of civil rights activists as black or white. There were persons of other races and ethnicities who were very much involved in the civil rights movement, one being Yuri Kochiyama (born Mary Yuriko Nakahara) a Japanese-American. She was born in San Pedro, CA. Her father, an immigrant, was arrested in 1941 by the FBI after the bombing of Pearl Harbor during WWII. Kochiyama's family was sent to an internment camp in Arkansas. The prejudice Kochiyama witnessed against Japanese Americans, led to her becoming a civil rights activist. She was present when Malcolm X was killed; she held his head as he was dying. Kochiyama was not new to the civil rights movement when Malcolm X died in 1965.
She is the author of "Passing it On".
To read more about Yuri Kochiyama, visit the following links:
Civil rights activist Yuri Kochiyama
Her devotion
Yuri Kochiyama
Tags: activist, American, Civil Rights, human rights, internment camp, Japanese, WWII 2 Comments »
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Are you going to spend your Easter Holidays in Bournemouth? Then check out this blog post! We have collected some of the best events going on during these days!
Come to decorate Easter eggs with World Choice Education, we will invite you to drink some coffee, tea or chocolate while you are decorating the traditional Easter Eggs, we have created a competition and the winner will receive an Easter Prize! Join the event!
Would you like to experience the medieval life in one of the most beautiful places in Bournemouth? This Easter the Wolfshead Bowmen and Companie of the Silver Arrow come to Corfe Castle and bring the past to life. A medieval encampment, demonstrations of combat, skilled archery displays, talks on the longbow and have-a-go sessions!
Begin the Boscombe Easter Egg Hunt. Weave your way around the curious path through high street, Sovereign Centre & Royal Arcade shops.
Visit the friendly shop keepers and collect an Easter Egg sticker, fill in the map and be in for winning an Easter Prize!
Participating shops will display a window sticker or poster to show they are taking part.
Now in its 5th year, the hugely popular Big Bournemouth Beer Festival returns to the BIC Purbeck Hall during Easter bank holiday weekend 2014! Bigger and better each year, the festival features over 200 beers from across the UK.
Face painting, games, arts, crafts and Easter egg trail (£2.50) on Church Field. Join in with their Easter activities and have a go at their special Easter trail with a Cadbury's Egghead prize – 10.30am-4pm.
Call office for more details 01202 707744.
The first annual Boscombe Food Festival will take place this Easter, 18th and 19th April, in Boscombe's Sovereign Shopping Centre.
The festival will showcase the culinary talents of local businesses to an expected 40,000 visitors over the two days from stands located along the centre's main aisles.
Easter Marquee with a Vintage themed Mad Hatters Tea Party, Arts & Crafts and free live music and entertainment.
Continued Easter Egg Hunt through shops, coffee shops & restaurants; promoting any local restaurants offering a good Easter Sunday Roast!.
Easter Bonnet and Mad Hatters parade.
By worldchoiceeducation in Asesoramiento estudiantil, How we help you, Student Advice, The UK, World Choice Education on April 10, 2014 .


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Home » Blogs » Ryan Russell's blog
By Ryan Russell | August 16, 2018
Quercus oblongifolia, County Road 368, New Mexico (click on images to enlarge)
I enjoy finding giant trees, and always keep an eye open and a tape measure handy. Some of my finds are only giants in the sense that they are large for their species, such as my National Champion Prunus hortulana (30 ft tall). When my family and I got the chance to traipse around New Mexico in the fall of 2016, acorns and photos were not the only things on my mind. I also brought my tape measure. For those not familiar with U.S. champion tree programs, the formula of height (feet) + circumference (inches) + 25% of average crown spread (feet) = total points. I personally do not care for the fact that only one quarter of the spread is counted, but that's a fight for another day.
Monster Silverleaf Thanks to Michael Meléndrez's knowledge of the state, he put us on some large specimens of Quercus hypoleucoides in the Gila National Forest on the first day of the 2016 Tour. The largest measured in at 81 ft tall, 84 in circ., and 63 ft spread for a total of 180.75 points. That is good for the new NM State Champion for its species. On that trip we also measured the new State Champion Englemann spruce (Picea englemannii) on top of the Sierra Blanca range, which came in at 300 (145 ft tall, 145 in circ., and 40 ft spread) total points.
Author next to New Mexico Champion and potentional National Champion Quercus gambelii, off NM-159, Elk Mountain, New Mexico, 18½ ft girth
Elk Mountain Mammoth In the fall of 2017, Michael Meléndrez held a second installment of the previous year's trip through New Mexico. Again, armed with my trusty tape measure I was anxious to get going. Michael had told us we would be seeing some huge Gambel oaks (Q. gambelii) on this first portion of the Tour and he was not kidding. After seeing a number of very large single-trunk Gambel oaks along a private drive, we ended up on Elk Mountain in the Gila NF. Michael knew of a huge Gambel oak growing in a mixed stand of ponderosa pine and Arizona cypress. This tree measured 75 ft tall, 221 in circ., 54 ft spread for a total of 309.5. It is the new NM State Champion and potential National Champion.
Enormous Netleaf The next day found us exploring Catwalk Canyon, near Glenwood, NM. We were excited to get a chance to see netleaf oak (Q. rugosa) among other desirable species. As we scrambled up through the canyon (past a certain point, the trail was wiped out by a flood) I noted a large Q. rugosa that I planned to stop and measure on the way back to the truck. After a nice walk, I stopped to measure the tree in question and with a score of 118 total points it is the new NM State Champion.
Left: New NM State Champion Quercus rugosa - Right: Quercus grisea, Coronado National Forest, Hidalgo County, 17½-ft girth
Gargantuan Gray Driving through the Coronado National Forest, in Hidalgo County, to see the National Champion Q. grisea, we walked up the little draw where Michael thought it was. We looked and looked, but couldn't seem to locate it. After about an hour, we finally found its remains. Apparently, it was hit by lightning, or a forest fire took it out and all that remained was a charred stump. A bit let down, we continued along Geronimo Trail, enjoying the flora. About a mile from where the former champ once stood, I saw a huge tree down in a bottom along a dry stream. I hollered at Michael to stop the truck and I bailed off into the head-high brush as Michael reminded me to watch out for rattlesnakes! The risk was worth it, as the huge gray oak was in fantastic shape, had lots of unique character and measured 60 ft tall, 203 in circ., and 72 ft spread for a total of 281 points. It is the new NM Champion and potential National Champion.
Grant County Giant Following a lead shared with us by Anna Forester, we drove to Grant County, NM to visit the site of a large Emory oak (Q. emoryi). Tsama Pineda led us through the property to a huge oak. It was truly impressive and had a large spread. Remains of what I could only imagine were an old mountain lion kill were lodged in the tree, which only added to the coolness factor. This new State Champion and potential National Champion tree measures 60 ft tall, 209 in circ., and 75 ft spread for a total of 287.75.
Tour leader Mike Meléndrez next to 17½-ft girthed new State Champion Quercus emoryi (left), and its 75-foot wide canopy (right), Grant County, New Mexico
Mexican blue oak, 13½ ft girth, near Arabela, NM
Big Blue We headed towards Lincoln, NM to revisit the area made famous by Billy the Kid and his Regulators in the 1880s. Nearing the Capitan Mountain Range, around the town of Arabela, we began to see Mexican blue oak(Q. oblongifolia). We stopped to check for acorns and I measured a tree I thought was a large specimen. Happy about that encounter, we continued on. However, a mile or two down the road we spotted a truly huge specimen growing right along the road. It made the first one seem puny and measured 48 ft tall, 161 in circ., and 54 ft spread for a total of 222.5. This again is the new NM state champion for its species and is the pending National Champion.
A Bonney Chinkapin The last standout on this trip was another from Lincoln County where Billy the Kid (aka William H. Bonney) once roamed. Almost by mistake, we stumbled upon a fantastic specimen of chinkapin oak (Q. meuhlenbergii), not a huge tree by eastern standards for this species, but certainly large in this region of the country. We noticed a large chinkapin oak near an old homestead. We wanted to take a look at it but no one was home to get permission from. Then as we were leaving, a neighbor came down and asked us what we were doing. When we explained we wanted to take a look at his neighbor's tree, he mentioned that he had one even larger, and gladly took us to his tree. It was larger indeed and even after losing a portion of the canopy years earlier it still measured 45 ft tall, 138 inches circ., and 51 ft spread for a total of 192.75 points. Not large enough for National Champion contention, but it is the new NM State Champion for the species.
New Mexico State Champion Quercus muehlenbergii, Lincoln County, 45 × 51 feet, 11½ ft girth
One of the challenges facing intrepid hunters of giant trees in New Mexico...
Again, I'd like to thank Michael Meléndrez for leading the Tour and sharing with us areas and trees not often seen by others.
Photos © Ryan Russell


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