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NDSU Softball Team Scores Early and Often
Pace Maier April 11, 2016 No Comments
KIM HILL | THE SPECTRUM
The North Dakota State softball team makes it look easy, especially in the first few innings of recent games.
The Bison (24-12, 6-0 Summit League) outscored Summit League opponent Indiana Purdue-Fort Wayne (10-29, 1-8 Summit League) 16-0 in a doubleheader Saturday at the Ellig Sports Complex in Fargo. And in the final game of the series beat IPFW 13-8.
In both games this weekend, the Bison scored all 16 runs in the first three innings of the contests. "Score early and often" is a motto the team has truly taken to heart. And in Sunday's contest the Bison scored six runs in the first two innings.
The Bison are destroying its opponents right out of the gate, outscoring them 81-16 in the first two innings of games this season.
NDSU is second in the Summit League for runs scored, and No. 57 nationally in scoring. In the last six games, the Bison have scored eight or more runs in each of them.
The parade of runs this weekend started in the second inning of the first game when Alyssa Reina hit a grand slam to give the Bison the 7-0 lead, and IPFW couldn't get any sort of rally going.
In the second game Julia Luciano and Maritza Lopez-Portillo both singled in the first inning to give the Bison yet another early lead at 4-0. NDSU piled on four more runs in the next two innings to take control of the game for good.
In Sunday's game the Bison scored runs off two singles, a triple, a double and Jackie Stifter was hit by a pitch that scored Cheyenne Garcia in the first two innings.
But all the credit can't go to the hitters. The NDSU pitchers shut down the IPFW offense entirely.
Jacquelyn Sertic and Kaitlyn Leddy threw back-to-back one hitters Saturday against the Mastodons. This season as sophomore Sertic has a low earned run average of 1.97 and after two wins this past weekend her record gets bumped to 17-5 on the year. And Leddy, a freshman, has been modestly successful on the mound this season for the Bison, with a record of 6-7.
The Bison aren't just stepping all over home plate; they are stepping over opponents, especially in the last 14 games. NDSU has won all but two of those games, including their last six. The last loss the team had was against Iowa State University on March 26.
NDSU will play in-state rival the University of North Dakota Wednesday at 4 p.m. at Ellig Sports Complex before heading to Brookings, S.D. for a three game weekend series.
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I have a really bad toothache and I can't find anything to help relieve it? I've tried cotton ball with Apple cider vinegar, acetaminophen, a rinse with hydrogen peroxide & none of those work. And I can't go see the dentist because they're closed.
Unfortunately there is no home remedy for dental pain, except over-the-counter pain medications and oil of clove. These are only temporary remedies and you will still need to be seen by a dentist as soon as possible. You can always call your primary doctor or make a visit to a walk in clinic or the emergency room at the local hospital. They will be able to prescribe you medication until you can be seen by your dentist.


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Mobile Legends: Bang Bang Reveals World Championship North American Qualifier
By: Niko
Aug. 31, 2021 /PRNewswire/ — MOONTON Games and Estars today announced the Mobile Legends: Bang Bang World Championship North American Qualifier, which will take place September 11-12 and 18-19, marking the largest qualifier in the region to date. The open qualifier will see the best teams from across the United States and Canada go head-to-head for a share of a $6,500 prize pool with the winning team receiving a spot at the prestigious Mobile Legends: Bang Bang M3 World Championship. The event will also play host to notable esports and gaming talents including host Jake "SirActionSlacks" Kanner, caster Austin "Capitalist" Walsh, and content creator David "Assassin Dave" Mao.
The NA Qualifier will feature a single-elimination bracket, with a best-of-three series played through the semi-finals and concluding with a best-of-five series for the top eight teams. Action from the quarterfinals, semi-finals, and final will be live-streamed on Twitch, Facebook, TikTok, and YouTube – promising two days of intense and exciting matches. Fans can tune in from 11:00 AM PDT on September 18 and September 19.
The $6,500 USD prize pool for the event will be split, with 1st place receiving $3,500 USD, 2nd place receiving $2,000 USD, and 3rd place receiving $1,000 USD. Over 2.7 million diamonds, the game's sought-after currency, will also be on the line for winners, participating teams, and viewers alike.
"It's an honor to be able to host our largest NA qualifier with Estars and provide more competitive opportunities in the region. With Mobile Legends: Bang Bang becoming one of the most-watched esports titles in the world, we have seen an incredible increase of players at a global level, including North America. We look forward to seeing the teams battle it out against the very best at the M3 World Championship," said Nicholas Chang, North America, Esports Manager at MOONTON Games.
As Mobile Legends: Bang Bang's most inclusive qualifier in North America to date, there will be no limit on the team registrations. With more competitive players than ever before, the qualifier aims to provide an opportunity for the United States and Canada to showcase their skills and become the best team in the world at the biggest Mobile Legends: Bang Bang World Championship ever hosted. Registration is currently open at https://smash.gg/M3NAQual.
The Mobile Legends: Bang Bang M3 World Championship is set to take place in December with more details on format, location, and prize pool set to be announced in the coming months. In its third iteration, the World Championship will feature the top 16 teams from across the world. The M2 World Championship was hosted in Singapore and saw Bren Esports emerge victorious after taking down Burmese Ghouls and cementing their place in Mobile Legends: Bang Bang history.
About MOONTON
Established in 2014, MOONTON is a global video game company dedicated to gaming development, publication and esports. With more than 900 employees worldwide, the company operates offices in Indonesia, Malaysia, Singapore, Hong Kong and mainland China. It has successfully launched a number of high-profile mobile games globally and has built long-term relationships with governments and esports organizations in more than 30 countries around the world. Mobile Legends: Bang Bang is its current star game and the leading mobile multiplayer online battle arena (MOBA) game worldwide.
About Mobile Legends: Bang Bang
Mobile Legends: Bang Bang is the most popular mobile Multiplayer Online Battle Arena (MOBA) game worldwide that brings communities together through teamwork and strategy. With over one billion installations and 100 million active monthly users, the award-winning game is among the top 10 most played in over 80 countries. With an extensive reach across the Asia Pacific region, the multiplayer is available in 139 countries with an expansive global esports presence.
About Mobile Legends Esports
Established in 2017, Mobile Legends: Bang Bang Esports serves as a platform for players to pursue their dreams of becoming esports athletes and illuminate opportunities within the international esports ecosystem. MLBB Esports has since expanded to multiple leagues, including the MPL series hosted in Southeast Asia.
SOURCE MOONTON Games
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We are accepting new patients for primary care.
California's Proposition 215 was the first statewide medical marijuana voter initiative adopted in the USA.
Board adopts statement clarifying implementation of California's Compassionate Use Act to insure California's physicians and consumers receive appropriate guidance under the law.


UBS Bank USA provides clients with FDIC-insured deposit accounts. Cash deposits in the accounts are insured by the FDIC to a maximum of $250,000 per depositor 1 including principal and accrued interest.
More information about federal deposit insurance is available at www.fdic.gov.
UBS is not associated with the above site and offers this link solely as a courtesy to its customers. UBS makes no representations or warranties with respect to the information contained in this third-party site.
1 Insured up to $250,000 (including principal and accrued interest) per depositor, for each account ownership category.


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Will Dean's Bad Apples: Rural Swedish Noir
On 4th October 2021 By Ewa ShermanIn Uncategorized
Fans of Will Dean's evocative, fiendish and compelling writing have been waiting for the latest instalment of The Tuva Moodyson Mysteries which follows Dark Pines, Red Snow and Black River, and the standalone novel The Last Thing to Burn. Ahead of the publication of Bad Apples this week on 7th October I am delighted to share Will Dean's thoughts and musings about nature and surroundings that inspire him.
Scandinavian forest in its autumnal glory
It only takes one…
A murder: A resident of small-town Visberg is found decapitated
A festival: A grim celebration in a cultish hilltop community after the apple harvest
A race against time: As Visberg closes ranks to keep its deadly secrets, there could not be a worse time for Tuva Moodyson to arrive as deputy editor of the local newspaper. Powerful forces are at play and no one dares speak out. But Tuva senses the story of her career, unaware that perhaps she is the story…
Here's what Will Dean says:
I'm a reader first and foremost, and I enjoy atmospheric books: gripping stories that immerse you in particular time and place. I like to feel as if I've fallen into a story. Like I'm living it. I still relish that magical childhood feeling of stepping through the back of the wardrobe for the first time. Entering a new world. Stepping into fresh snow. That's what I like to read so that's what I try to write.
Before I begin a first draft I spend many hours inside my own head, walking around the streets of Gavrik (a fictional town in Värmland, central Sweden). I reacquaint myself with the layout of the place, the small police department, the one bar, the recycling station, the gothic liquorice factory, the hunt store, and, of course, Tuva Moodyson's employer, the Gavrik Posten newspaper.
Gavrik (and now Visberg, its Twin Peaks-ish hilltop neighbour) feels as real to me as any town in Scandinavia. But what inspired me to dream up these places?
First, I was heavily influenced by my own surroundings. I live partly off-grid, deep within a huge Swedish elk forest. We use wood for heating and cooking and we take water from our own well. Moose regularly trample through our land (because it's actually their land). My nearest town is about a half hour drive away (when the snow's not too deep). On a Friday night there's nobody out on the streets. It's a quiet place where people tend to keep themselves to themselves. My town's largest employer is a biscuit factory. In December the streets smell of gingerbread. In contrast, Gavrik's streets smell intensely of aniseed; the ice-cold air is laced with it. Unlike my local factory, the Grimberg Liquorice is a place of secrets, unexplained accidents, and toxic co-dependency. The town relies on the factory for secure jobs. Generations of locals work there. And the factory relies on the town for reliable labour. The locals and the factory are locked together in a slow death spiral.
Second, I'm obsessed with small towns in general. I grew up in the East Midlands around several market towns, never inside, always on the edge looking in. I find them fascinating. Where you have one main employer, the town dynamics can become extreme. The factory or warehouse or manufacturer can be as important to local people as a school or church. The Grimberg factory in Gavrik can't survive without the town and the town can't survive without the factory. They live or die together. And the cocktail of myths, secrets and grudges you find in any small, cut-off community is an electrifying set-up for a story. I'm fascinated by the lives of ordinary people living in ordinary places. It is their stories that I want to tell, and a small town setting helps me to focus and go deep.
Finally, I find the nature here utterly intoxicating. Distinct seasons. True wilderness. A crime series set in Scotland or Ireland can bring a sense of isolation, but we also have bears, wolverines, lynx and wolves to contend with. Those elements (Åsa Larsson writes bears especially well), combined with extreme seasons, lend a backdrop of menace. When I imagine the beginning of a Nordic tale I sometimes visualise the opening scene of The Shining. A grand vista. One car driving along a snaking road in the wilderness, venturing further and further from safety. Add a blizzard in to the mix (as Ragnar Jónasson and Peter Høeg do to great effect) and you almost create the sense of a locked room mystery or a closed set. It's a delicious landscape for suspense.
I've been here for over a decade now. Rural Sweden is home. As long as I continue to find this world (and its inhabitants) fascinating, I'll continue to tell these stories. Each one is a real pleasure.
You can buy the latest Tuva Moodyson's story via the links Bad Apples – Bookshop.org and Bad Apples – Amazon or in a local bookstore.
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Vocalist Matt Schultz stated: "With this record, we wanted to be more transparent. We wanted to capture the sentiment of each song, and whatever emotional response it provoked, to be really honest to that."
Daniel Sylvester said that frontman Matthew Shultz "has hit the mark lyrically and vocally here, inviting listeners into the emotionally charged and honest world that Cage the Elephant inhabit."


Give a gift that will have a lasting impact this holiday season.
Blessing the poor happens year-round. Your contribution to Cross Catholic Outreach will continue to provide essentials for those around the world.
Here's how it works: the vital items you select and sponsor through the catalog are shipped to poor families in need. As you'll see, this catalog isn't a collection of items for people who have everything. It is a way to share your faith and honor a loved one while blessing the poor overseas.
The gift items below may seem simple by American standards, but they are items difficult for the poor to obtain. Select and sponsor one or more of these gifts, and you will be making a meaningful impact on the life of a needy child or family overseas. When you give on behalf of a friend or loved one, you can also share the Christmas joy with them. They'll be notified that you made this profound gift to the poor on their behalf.
Bless a mother and a baby in need with a gift of diapers.
Recommended Gift: $16.50 will provide a month's worth of diapers for a new mother and her baby.
Deliver clean water to poor villages that rely on contaminated sources.
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Send milk to orphans and vulnerable children in need.
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Send a gift that will provide both comfort and protection.
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Send a gift of the spirit to someone in need.
Recommended Gift: $275 will provide an orthopedic aid for a single disabled student. $2,750 will provide orthopedic aids for all 10 disabled students.
Send a gift that could save a life.
Recommended Gift: $21 can send 2 bottles of basic medicines to clinics in need.
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Recommended Gift: A gift of $26 will provide 3 mosquito nets and help prevent malaria.
Send a gift of dignity and help a poor family stay warm, clean and dry.
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Give the gift of education for children in need.
Recommended Gift: $33 will help provide 2 children with backpacks and school supplies.
Provide classroom furniture for classrooms at Christ the Redeemer School in Zambia.
Recommended Gift: A $1224 gift will help provide furniture for one classroom.


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Home › design › William Kentridge's animations are the true stars of The Magic Flute at Milan's La Scala
William Kentridge's animations are the true stars of The Magic Flute at Milan's La Scala
4 April 2011 by gramilano Leave a Comment
Last night Die Zauberflöte bowed out from the La Scala's stage, though it won't be away for long I'd guess. With this production the theatre has united audience, critics and even the infamous boo-ers from the gallery in praise both musically and theatrically, a rare event.
Although the casting was sound (with a fiendishly accurate Albina Shagimuratova as the Queen of the Night) the evening was stolen from them by William Kentridge's concept, above all his animations which zig-zagged across his sets. A human-sized singer stands little chance of competing with such vigorous designs flashing about the stage. At any given time 90% of the audience were ignoring the singers on a visual level, which is unfortunate because the Three Ladies (Aga Mikolaj, Heike Grötzinger and Maria Radner) and Papageno (Alex Esposito) were excellent.
William Kentridge is a South African artist best known for his animated films. These are constructed by filming a drawing, making erasures and changes, and filming it again. He continues this process meticulously, giving each change to the drawing a quarter of a second to two seconds' screen time. A single drawing will be altered and filmed this way until the end of a scene. These drawings are later displayed along with the films as finished pieces of art. These scratchy little designs then quiver with life as they are projected as white light across the black and white set, often swirling dramatically over the entire visible area. The projections came from the Royal Box in the centre of the theatre, from two positions left and right of the prompt box, and from behind the backdrops also giving the opportunity to use actors in shadow-play.
The use of these effects is witty and impressive. Woodblock temples are animated and zoom us in and out of scenes as in a movie. As Papageno vainly waits for Papagena to appear a scaffold and a hangman's noose are slowly drawn in light during his "eins, vei, drei", and his friendly birds morph in to vultures. During the Queen of the Night's arias constellations whirr around her, and during the trials Pamino and Pamina are engulfed in white-hot flames and whitewater rapids. Even if the result is sometimes overpowering for the singers, it is worth it for the emotional punch it gives the story.
In the early 1980s, Kentridge studied mime and theatre at the L'École Internationale de Théâtre Jacques Lecoq in Paris. He originally hoped to become an actor, but he reflected later: "I was fortunate to discover at a theatre school that I was so bad an actor [… that] I was reduced to an artist, and I made my peace with it.". Here he has found the perfect vehicle for his dual passions.
Filed Under: design, music & opera Tagged With: La Scala, Magic Flute, Milan, South Africa
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While relations between the Georgian and Russian governments can be described as troublesome, Georgians remain positive towards the Russian people. According to the Caucasus Barometer 2010, 73% of Georgians approve of doing business with Russians, compared with 79% who approve of doing business with Ukrainians (the highest rated result for this question). Moreover, 42% of Georgians approve of Georgian women marrying Russians which was the second highest rated result for this question after Ukrainians (45%). In addition, data from the Caucasus Barometer suggests that people who have a better knowledge of Russian are more likely to approve of Georgian women marrying Russians. The data also shows that 90% of Georgians think they have at least a beginner's level knowledge of Russian, while 32% think they have at least a beginner's level knowledge of English.
Socio-cultural characteristics such as a sizeable Georgian diaspora in Russia and Orthodox religion may also play a role in the positive perception of Russians by Georgians. The Georgian Ministry of the Diaspora estimates that the number of Georgians residing in Russia varies between 800,000-900,000 people. Also, the strong role of religion in Georgian society might help to explain positive attitudes towards Russians. Relations between the Russian Orthodox Church (ROC) and Georgian Orthodox Church (GOC) are good. For example, the ROC recognizes the canonical authority of the GOC over the breakaway territories of Abkhazia and South Ossetia as was confirmed by both patriarchs during their August 2011 meeting in Kiev to commemorate St. Vladimir Equal-to-the-Apostles the Baptizer of Russia.
Nevertheless, positive attitudes towards the Russian people do not influence Georgia's predominant pro-Western orientation. According to the 2010 Caucasus Barometer, 70% of Georgians support membership in NATO and 71% think that English should be a mandatory language in schools, while only 16% think that Russian should be a mandatory language in Georgian schools. Georgian-Russian political relations are also at odds with the different approaches towards Abkhazia and South Ossetia. Tbilisi claims both territories as an integral part of Georgia, while Moscow has recognized their independence.
Georgians have positive attitudes towards the Russian people despite political turmoil between the Georgian and Russian governments. We do not have data on Russian attitudes towards Georgian people. However, do you think that positive attitudes between people could pave the way to a Georgian-Russian rapprochement?
Attitudes Towards Public Opinion Polls in Georgia (Part 2)
Increasing knowledge of and trust in polls are clear challenges for pollsters in Georgia. Even though public opinion polls are regularly criticized, there is still a public demand for them. A majority of Georgians believe that they don't have a proper understanding of how public opinion polls are conducted, but they agree that polls help everyone to better understand the society they live in.
Russia as a threat: the Ukraine crisis and changing public opinion in Georgia
Following 2012 parliamentary elections, attitudes toward Russia in Georgia shifted. While in 2011 51% of the population considered Russia the main enemy of the country, in 2012 only 35% reported the same. Moreover, the share of Georgians who named Russia as Georgia's main friend increased by 5%. In a post on the CRRC-Georgia blog, this change was explained by a so-called "spiral of silence".
Georgia: A Liberal or Socially Conservative Country?
How justified is it for Georgian women to bear a child or have sex outside of wedlock? Is the Georgian population tolerant towards homosexuals? What are views on issues such as these in the light of the western-oriented political course of the country? How do men and women compare in terms of liberal attitudes? To address these questions, this blog post presents the results from two waves of a nationwide public opinion survey entitled "Knowledge and Attitudes toward the EU in Georgia" conducted by CRRC in 2009 and 2011.
Religious practices across the South Caucasus | the Data Initiative
Data snapshot: how do religious practices compare across the Caucasus? In our Data Initiative, we included questions on religion, and we tried to unpack the concept further: rather than only asking about the importance of religion, we linked it to practice. Thus, we asked how often people attend religious services, how often they pray, and how often they fast -- since these are comparable components across Muslim and two separate orthodox religions.
Russian Public Opinion | Levada Update
And here is an update on Russian views, made available by the Levada Center on the 22nd of September. As previously stated, this indicates that Russian public opinion generally supports the government's course.
Back to the USSR? How poverty makes people nostalgic for the Soviet Union
A recent CRRC/NDI survey asked whether the dissolution of the Soviet Union was a good or bad thing for Georgia. People's responses were split almost evenly: 48% reported that the dissolution was a good thing, whereas 42% said it was a bad thing for the country. Such a close split raised questions in the media about why people took one view or another.
Who makes political decisions in Georgia: What people think
Bidzina Ivanishvili resigned from the post of prime minister of Georgia on November 20th 2013, and in his own words, "left politics". Speculation about his continued informal participation in the political decision-making process began even before he resigned and still continues. Some politicians think that Ivanishvili gives orders to the Georgian Dream party from behind-the-scenes, while others believe that he actually distanced himself from politics. Politicians, journalists and experts continue to discuss the situation. Meanwhile, a majority of Georgia's population thinks that Bidzina Ivanishvili is still involved in the governing process and that his informal participation is unacceptable.
Which groups name Russia as Georgia's main enemy?
In 2017, 40% of the population of Georgia named Russia as the main enemy of Georgia. Yet the opinion that Russia is the main enemy of the country is not equally present in different demographic groups. This blog post uses data from CRRC's 2017 Caucasus Barometer survey to gain a better understanding of the characteristics of those who report Russia is the country's main enemy.
Analysis | Who is afraid of the Lugar Centre?
CRRC-Georgia investigates who is more susceptible to Russian-pushed conspiracies surrounding Georgia's US-funded Lugar Centre.
In Georgia, a conspiracy about the US-funded Richard Lugar Centre for Public Health Research in Tbilisi has recently gained traction. As CRRC-Georgia's USAID-funded research shows, Georgia's far-right groups eagerly picked up on this conspiracy and blamed the centre for the seasonal flu outbreak in early 2019.


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Pakistan mulls blocking US supply lines into Afghanistan
Khurram says two countries not talking to each other
Monitoring Desk
ISLAMABAD - Pakistan says it is reassessing strained ties with the United States, a move that could lead to halting supply lines into Afghanistan.
Foreign Minister Khurram Dastgir Khan made the remarks to VOA exclusively a day before an international task force is to place Pakistan on a terrorism-financing watch list at the urging of US President Donald Trump's administration.
The Paris-based Financial Action Task Force, or FATF decided in February to include Pakistan in its so-called "gray list" of nations that are not doing enough to curb terrorism financing.
"We have reached an impasse in which we have this very strictly formal diplomatic communication is happening, so the US ambassador in Islamabad comes and speaks to us in the Foreign Office and our ambassador in Washington goes and speaks to the State Department. But that's not really communication, the two countries are not speaking to each other," Khan said.
He blamed the Trump administration's "adamant" refusal to communicate for "the low ebb" in mutual ties. "At the moment Pakistan is not being heard. Pakistan is just being vilified and castigated in Washington without being heard at all. It is this situation."
READ MORE: US confirms first Wuhan coronavirus case
The only communication that currently exists apart from the formal diplomatic interaction, Khan said, is that US CENTCOM commander General John Votel has been speaking to Pakistan's Army Chief General Qamar Javed Bajwa.
"Formally Pakistan is still a major non-NATO ally and for the United States to actively target Pakistan in FATF, trampling over all regulations and precedents is by necessity forcing us to rethink," lamented the minister.
Khan, who also heads the defence ministry, acknowledged that American civilian and military financial assistance programmes have over the years helped Islamabad meet its crucial budgetary shortfalls. But the expected financial support from Washington this year, he said, has dropped to 'zero' for the first time in a decade.
Khan noted, however, that despite all the tensions and bitterness in mutual ties, Pakistan has kept its ground and air lines of communications open for US and allied nations to ferry supplies to their troops in landlocked Afghanistan.
"Yes, we have to consider all options that are in front of us because it would appear to us that the US is following what can be termed a non-violent compellence of Pakistan," the minister said when asked whether his country is close to shutting down the supply lines.
Khan underscored the need for the two countries to communicate and speak to each other despite maintaining divergent views on the war in Afghanistan, the longest in US history.
"The fact that that longest (US) war shows no sign of turning positive for the US is all the more reason that whatever differences or grievances we might have Pakistan and the US should be communicating at different levels… because ultimately this is a relationship, at least in our view, bigger than Afghanistan and has been bigger than Afghanistan."
Khan said at a time when US and Western partners have "abandoned Pakistan to terrorism" and continue to ignore his country's "unprecedented" sacrifices in fighting terrorist groups, Islamabad's traditional ally China has stood by it and brought billions of dollars in historic direct Chinese investment.
READ MORE: UAE has no right to interfere in Libyan affairs: Libyan PM
"Russians are essentially (also) walking into a vacuum created by the absence of our American friends," the minister said pointing to Pakistan's rapidly improving relations with old rival Russia.
At a public talk in Washington last week, John Sopko, the US Inspector General for Afghanistan Reconstruction (SIGAR), stopped short of dismissing Washington's narrative of singling out Pakistan for the Afghan military stalemate.
"We keep referring to Pakistan as being the key problem. But the problem also was that the Afghan government at times was viewed very negatively by their local people and what you really need is to insert a government that the people support, a government that is not predatory, a government that is not a bunch of lawless warlords," observed Sopko.
He went on to say that the US policy of pouring in billions of dollars in these unstable environments contributed to the problem of creating more warlords and powerful people who took the law into their own hands.
"In essence, the government we introduced, particularly some of the Afghan local police forces, which were nothing other than warlord militias with some uniforms on, were just as bad as the terrorists before them," said Sopko who is overseeing US spending to identify fraud and to prevent it.
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A new plastic material has been created that could reduce pollution recently. This new plastic is crated from sugars and carbon dioxide. According to the report, no hazardous chemicals are used in the process.
@woodman a good move but will it be used? we already having composting plastic substitutes (not sure about cleanliness of manufacturing) but you rarely see them being used.


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UK National Parks: Facts & Figures
The UK's national parks were established in 1951 with the goals of conserving and enhancing the country's natural beauty, wildlife and cultural heritage. There are now fifteen around the UK. Ten are situated in England, three in Wales and two in Scotland. In this infographic, Cottages to Rent offers insights into these stunning regions with information about their geographical locations and visitor numbers.
5 Things You Can Do Around the Home to Help the Environment
In recent years, what was previously referred to as climate change is now often being referred to as 'the climate crisis'. This indicates that environmental concerns are more pressing than ever before. Many people want to take action, but helping the environment can seem overwhelming. It is hard to know where to begin, but changing behavior at home can be the best place to start.
Environmental Issues Faced by Americans
All the living things on the planet depends on a clean and healthy environment for enhanced survival opportunities. However, we are facing a significant fall in environmental quality. Apart from the CO2 emission, the USA is facing soil pollution, air pollution, water pollution, garbage disposal, global warming, deforestation, acidification of ocean water, ozone layer depletion, radioactive contamination, mine pollution, overpopulation, and nano pollution.
Meanings of the Names of the 10 Highest Mountains on Every Continent
Mountains have been a source of awe, adventure, struggle, and survival since the dawn of humanity. It is no wonder that they are given epic names that command respect. This infographic explores the meanings of the names behind the 10 highest mountains on every continent.
20 Reasons Why Vegetarian Diets Are Good For The Environment
Environmental concerns are becoming a major factor in people's lifestyle choices, from the brands they buy to the food they consume. Dividing the reasons into key areas of environmental concerns — including water consumption and the oceans, carbon emissions and pollution, land and deforestation, and animal welfare — the following infographic lists 20 reasons why vegetarian diets are good for the environment.
20 Practical Reasons to Switch to Reusable Grocery Bags
As the battle for making the world plastic-free heats up, the search to find suitable eco-friendly packaging options is also increasing. Eco-friendly is not just about green alternatives but also sustainable ones. As the search intensifies, cotton emerges as one of the most convenient alternatives. It is reusable, sustainable, biodegradable and capable of carrying significant weight.
What Is Global Forest Watch and How Do You Use It?
You don't necessarily have to be a "tree hugger" to care about trees. The health of our trees and forests is a great indicator of the overall health of Earth, its atmosphere, and its biosphere. And seeing that Earth is currently the only planet we have to inhabit, it makes sense for us to all take a greater interest in the things that make for a healthier planet…including its trees and forests.
The Greenest Cities in the United States
Many cities are adopting greener, more sustainable practices in order to preserve the planet for future generations. From providing reliable public transportation to producing sources of renewable energy, reducing our carbon footprint is a monumental task that must be done. Which cities in the United States are doing the best job at becoming greener?
Could We Halt Climate Change by Switching to a Bug-Based Diet?
The world is struggling and if we don't find creative ways to make a real difference and halt climate change, the Earth is going to continue to suffer. This infographic explores whether switching to a bug-based diet could halt climate change, through exploring relevant environmental, cultural and agricultural statistics.
Building a Sustainable Future: 8 Ways We Reduce Our Environmental Impact
In appreciation of Earth Month, the team at Global Furniture Group shares with you their story of building a more sustainable future for employees, customers and partners. Their sustainability report outlines the significant steps they take to limit environmental...


We expect to see HLFS employment rebound from its Q2 dip, with the Q3 unemployment rate expected to ease to 4.7%, its lowest since 2008.
Pay equity settlements are expected to push annual LCI wage inflation to 1.9%, a three-year high. The bias is for a modest strengthening in wage inflation despite slowing employment growth.
Firming LCI wage inflation should dispel the notion of OCR cuts, whilst considerable uncertainties on the outlook and policy backdrop are expected to encourage continued inaction on OCR settings.


Download and play Street Rod SE for PC DOS now!
Choose from 8 brand new stickers.
This is Street Rod SE (Special Edition) and features a standard Street Rod version with 25 replacement cars.
- Added Street Rod Car Data Disks.
- Removed copy protection screen.
- Fixed highlighting of the letter 'I' in first splash screen.
Luís Vasquez for finding the Data Disks.
Tiago Lopes for supplying the splash screen fix.
Thanks so much for your work! This is my favorite game from when I was a younger lad.
Thanks, its cool to see a classic with some new content.
Is the Chevy Styleline cheat in this game as well but with a different car?
I haven't figured that out yet. What I did is create a savegame with the original Street Rod (after using the cheat) and copy it to the Street Rod SE folder, works like a charm.
Doesn.t work, even in compatibility mode.
Btw, is Street Rod Online back in business now?
No, the Street Rod Online project has been put on hold.
SWEET! This website is a gold mine. Thank you for all your efforts! Loving this game again.
WOW!!!! blast from the past and its updated… amazing!!!!!!!!!!!!
Does this replace 25 cars or does it add 25 cars?
Whoaa, this is so awesome, and it has the Plymouth Fury in it! Christine, anywone? I missed that car in this game as a child… I thought it would fit well but then again, you never see a Plymouth Fury anywayz, it's just the whole movie that made me love it, same goes for the DeLorean. You did something really special here Marco! 25 years went by… we all had to miss these extra's, but you brought it back to life!
You're welcome (: and greetings to all the Tweakers who happen to visit this page.
First of all, this is amazing stuff. Hilarious.
One question though, is there a way to add the cars, instead of replace them?
We played this non-stop in college. However, now I can't remember the keyboard commands for the actual racing (Gas, shift, brakes, etc). Any help out there.
right off hand i thought gas was arrow up and brakes arrow down as was turning L and R arrows. Wasn't shift the shift key???
HELP!!! Is there a version that works on windows 7 64 bit? My old floppy won't run it.
I can't believe that people are playing this! That is awesome! I was the original artist that drew all the graphics and every car for the first street rod. I used an Amiga and "painted" pixel by pixel.
I can't even imagine how it might feel to see that SO many people still play this game, every pixel you painted gave us a lot of joy. It has been many years since Street Rod, yet I never felt the same with any game. Nowadays all is about hyper-realistic graphics, physics, sound… but they miss something, and it's the magic this game made us all feel, from the sparkling stars on the intro to the "Chicken!" when trying to pop the king's hood, the drive-in and the sleeping guy in the gas station.
I'm from south america, and most US movies I saw when I was a child shown me a perspective of the "american dream", my childish dream was to be one of those guys, tuning a muscle car and going pink slip "all-in" or taking a walk back home if I didn't have what it takes. You weren't playing rambo style like in any NFS, you could really feel being that guy, struggling for it.
Thanks Judy, thanks for those pixels, for those hours you guys spent making this game.
Have never even heard about additional data disks. Played regular street rod for many hours in 90s on PC. Although I don't feel any difference between this version and the regular one as I'm more enjoying the game mechanics rather than content, I thank you heartly for making this release public! It's always very exciting to be able to run rare asset-like software, especially if it brings back joyful memories. Hope to see more exciting news regarding this project in the future.
Is open source a possibility? I mean, the fanbase would surely be interested in updating and adding to what's already here.
Unfortunatelly the source code of the original game is lost.
Adding new cars is not much important thing for this game. Game is too easy, that`s the main problem. After 15 minutes of playing I already have fastest car and then game became boring. Better choice would be to mod Street Rod 2.
Is there a way that the original cars could be added instead of replacing the original ones? At this point it's not SR1 but rather SR1.5. I'm not complaining about having new cars but for people who want to play the original street rod this doesn't seem like the best option. I will enjoy this tho, it will be nice to have no idea what is the best for an hour or 2…lol I would recommend playing the originals on WinUAE tho if you want to play them. They look better and have all the cars you are used to.
I have a MAC operating on osx 10.7.5, cannot figure out how to download it to make it work. Is it even possible??
Download DOSBox for OS X and run it from there.
Get Boxer (http://boxerapp.com/) and play (almost) every DOS game you want on a Mac.
Whooops! found an oopsie on it! If you try to play it in hercules emulation mode (just for the fun of it, as when I was young that was what I had) the cars won't be shown properly.
I had to rename my files, so the easiest way is to make a new file in your game file, I named my SRSE, then when you download the content drag it into your SRSE file, you see an icon marked application under the classification type (means what type of file it is), this is the game itself, rename it to whatever you like I named mine SR, because as mentioned in Street Rod 1 and 2 the application is named SR…(note: when you drag these files into the SRSE file make sure they are not in another file!!!! you only need the main file everything else must be lose in able for this to work….hope that makes some sense…so when you type in your commands it will be mount c: c:\games (that will open your game file), then type c: (that will tell it to search for the c drive), then type cd srse (that tells it to open the fill srse), then type SR (or whatever you named your application, this will load/launch the game)…hope this helps, Ive used this process for other games as well like DOOM, it works very very well!


text:
Challenger Benny Gantz fails to form Israeli government, deepening political crisis
Benny Gantz, head of Blue and White party, gives a statement ahead of a midnight deadline in Tel Aviv on Nov. 20, 2019. Gantz has informed the president that he was unable to form a coalition government. (Amir Cohen/Reuters)
Steve Hendrix and
Steve Hendrix
Jerusalem Bureau Chief Steve Hendrix has written for Foreign, National, Local and most other sections of the Post.
Ruth Eglash
Reporter covering Israel and the Palestinian territories
November 20, 2019 at 1:13 PM EST
JERUSALEM — Benny Gantz, the former army chief, failed in his month-long attempt to put together a governing coalition Wednesday, prolonging Israel's protracted political gridlock and making it likely that voters will have to endure a third national election in less than a year.
Gantz, who has rocketed to the top tier of Israeli politics, caused a stir in October when he became the first person other than Benjamin Netanyahu to be given a chance to form a government here in a decade. Twenty-eight days later, his mandate to try is expiring with no parliamentary majority in sight. After weeks of negotiation among Israel's fractious parties, the deadline has come and gone, another way station to nowhere in the country's year-long political stalemate.
Gantz said in a statement Wednesday that he had informed Israeli President Reuven Rivlin that it was not possible to form a government.
"I left no stone unturned. I sifted through every grain of sand," Gantz said in a televised address. He accused Netanyahu, the prime minister, of negotiating not in good faith over a possible unity government but "with childish videos and slogans."
For the next three weeks, the law allows any member of the Knesset, Israel's parliament, a chance to do what Gantz and Netanyahu could not: cobble together the 61 votes needed to form a government. If this, too, falls short, as most analysts predict, the country's deja-vu nightmare will continue with another election, probably in March.
"Israel is caught in a cul-de-sac," said Daniel B. Shapiro, former U.S. ambassador to Israel and research fellow at the Institute for National Security Studies in Tel Aviv. "There just seems to be no workable coalition among the parties as they were elected."
Israel is a country deeply divided, and not just along a single fault line but a spider web of them. A range of parties split on questions of religion, security and the role of Arabs in Israeli society are wrestling for influence. At the center is Netanyahu, a polarizing leader who is likely to face indictment on corruption charges by the end of the month.
"You have too many crosscutting interests and personalities and a prime minister fighting for survival," Shapiro said.
The breakdown in governance is roiling a country that has prided itself in recent decades on stable if raucous leadership. As the months have passed, concern has grown that budgets and planning are beginning to suffer at a time of growing tension in the region.
The Israeli military that Gantz used to lead has been busy in recent weeks conducting operations against militants in Gaza and Iranian military targets in Syria. But army officials, speaking on the condition of anonymity to talk candidly, say they need a government in place for long-term strategic planning and budgeting.
"Things are running by themselves, without the politicians," said Aviv Bushinsky, a political commentator and former Netanyahu staff member. "That can be both good and bad."
Analysts don't know how to predict what the next phase will bring because they've never seen one like it. Never before has Israel's parliamentary system had to trigger the coming 21-day free-for-all that allows for any lawmaker to play government builder.
Most say the dynamics that have so far stymied the politicians won't change. As has been the case for months, all eyes will be on would-be kingmaker Avigdor Liberman, the hawkish former defense minister whose resignation from the government exactly a year ago helped spark the political uncertainty.
On Wednesday, Liberman announced that he would support neither a minority coalition led by Gantz nor a bloc of right-wing, religious parties led by Netanyahu. Both leaders had been trying to entice him into an arrangement, but both options appeared to conflict with his secular, right-wing ideology.
Liberman, head of the Yisrael Beiteinu party, has been a wild card since the first election this year, in April. After that vote, he refused to join a Netanyahu-led coalition because of its alignment with religious factions.
Since the September election, Liberman has refused to back either candidate, calling on Netanyahu and Gantz to bring their parties together in a secular unity government.
Liberman said in his news conference that he would not cooperate with a faction of Arab parties, which he has consistently referred to as a "fifth column." This rules out the option of Gantz forming a minority government backed from outside the coalition by 13 Arab lawmakers. Liberman also reiterated his position of not joining a government with Netanyahu and parties representing ultra-Orthodox Jews and a group of Jewish settlers, which Liberman has called "messianic."
In reality, most analysts say only Gantz or Netanyahu have a chance at getting enough support to prevail. All sides will be under pressure to make deals, as the idea of a third election is vastly unpopular among exhausted voters.
The 21-day window effectively evens the playing field between Gantz and Netanyahu, although Netanyahu has a slight edge because he has the support of 55 right-wing and religious Knesset members.
Gantz could give in and join Netanyahu in a national unity government. If this were to happen, it is likely that Gantz's Blue and White party would disband. Gantz's number two, Yair Lapid, formerly head of the Yesh Atid party, has stated that he will not join a government with a prime minister facing indictment charges. Moshe Yaalon, a former defense minister, has expressed the same. If these two remain outside, Gantz could realistically join Netanyahu with only 15 Knesset members.
If no deal is reached by Dec. 11, the third campaign will begin (or before, if the Knesset simply gives up and votes to dissolve itself earlier).
But would another trip to the ballot box change much? Polling so far suggests no great shift in the vote. But one thing would be different: If Israel's attorney general hands down corruption indictments against Netanyahu as expected, the prime minister would be under an unprecedented legal cloud during the campaign.
"That's the one thing that would be different in a third election," said Shapiro. "Would that change votes? Would he even be eligible to run?"
Bushinsky, for his part, thinks someone will budge under the pressure, producing a compromise and a government sometime in December. If not, he predicts the third election will do the trick.
"We will not have a fourth one," he said. "If we have a fourth one, Jerusalem will become a new bastille."
Today's coverage from Post correspondents around the world
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On March 20, 2018, the FDA granted Seattle Genetics, Inc. approval to market Adcetris® (Brentuximab Vedotin), in combination with chemotherapy, for the frontline treatment of patients with classical Hodgkin lymphoma (cHL) . The standard frontline regimen for patients with cHL is a four-drug chemotherapy regimen, ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine); however, up to 30% of patients are refractory to treatment or relapse after treatment . Brentuximab vedotin (BV) is a CD30-targeted antibody-drug conjugate that selectively delivers a cytotoxic agent to cHL cells, thus reducing systemic toxicity and enhancing anti-neoplastic activity . Brentuximab vedotin was previously approved as a salvage treatment and post-transplantation consolidation therapy for patients with cHL as well as for the second-line treatment of systemic and primary anaplastic large cell lymphoma and CD30expressing mycosis fungoides .
The most recent approval was based on the results of an open-label, multicenter, randomized phase 3 trial, ECHELON-1, comparing brentuximab vedotin, doxorubicin, vinblastine, and dacarbazine (A+AVD) to standard ABVD therapy for the frontline treatment of patients with stage III or IV cHL (NCT01712490) . A total of 664 patients received A+AVD while 670 patients received ABVD. Efficacy was based on a 2-year modified progression-free survival (the time to progression, death, or noncomplete response and use of subsequent anticancer therapy) rate which was 82.1% for A+AVD group and 77.2% for the ABVD group . Overall, patients receiving A+AVD experienced a 23% reduction in the risk of failure of the primary chemotherapy treatment. Additionally, treatment with A+AVD reduced the incidence of pulmonary toxicity supporting its use in this indication.
ADCETRIS® (brentuximab vedotin) for injection, for intravenous use Drugs@FDA: FDA Approved Drug Products March 20, 2018 [cited 2018 April 26]; Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/125388s097lbl.pdf.
Connors, J.M., et al., Brentuximab Vedotin with Chemotherapy for Stage III or IV Hodgkin's Lymphoma. N Engl J Med, 2018. 378(4): p. 331-344.
Phase 3 Frontline Therapy Trial in Patients With Advanced Classical Hodgkin Lymphoma. ClinicalTrials.gov August 1, 2017 [cited 2018 April 27]; Available from: https://clinicaltrials.gov/ct2/show/NCT01712490.


Electronic engineer with broad development in the area of the information technologies, with 25 years of experience. In his career has developed in various roles starting from technological support specialist to customers through technologies consultant and later leading work teams and advised commercial management in the development of technology projects for its clients. Extensive knowledge of operating systems, applications, database and servers in mission-critical technologies and virtualization technologies. Easy adaptability and excellent interpersonal relationship.
Leader of unit composed of thirty-four people in charge to operate, support, maintain, design solutions and to implement them in a dense ultra datacenter of environmentally friendly technology.
Leader of a team of seven engineers of different specialities responsible for configuring custom based solutions (hardware and software) information technology for our customers. Work of pre-sales and subsequent assistance to the project team that implements solutions. Development of products for the supply of the company.
Support for a sales team of information technology from IBM and other brands to provide its customers tailor-made solutions.
Technological support of the infrastructure of information technology of the Bank consists of central servers, networks, communications, storage, and personal computers.
Electronic engineering with mention in digital systems and communication. Learn electronic systems of data transmission and voice through various technologies of modulation.


Did you forget to order a yearbook? If so, don't fret, you can still order one online!
Kindergarten Registration For Next Year Is Open!
Click here to sign up for an appointment to register your new kindergartener for the 2019-2020 school year.
Our New Online Attendance Forms!
Tired of waiting on hold? Worried the note you sent with your child might get lost? Do it all online now! Submitting a student absence or change in dismissal has never been easier thanks to our new online forms!
Come enjoy some springtime music at Rose Hill! We will be having a joint concert with performances by our wonderful chorus, band, and strings! The concert will be held on Thursday, May 2 from 6:00 - 7:00 p.m. in the Rose Hill gym. See you there!
Get a jump on the Kindergarten year! Monday, April 29th, from 1:30-3:00 Kindergarten Orientation will be held. Come and learn what is needed for Kindergarten registration.
Learn more about how to register for the Spanish Immersion program! If you have a student who is going to be a rising Kindergartner or 1st grader, you will need to enter into the lottery. It's important to have an understanding of the process as well as the timeline.
Test dates for May Standards of Learning have been posted and are available in our Calendar of Events.
Rose Hill Players presents "Let the Games Begin"!
Last year's presentation, "Pirates of the Curry-Bean", was a huge success! Whether you want to be part of the play or just watch, click here for more information!
Check out our latest News You Choose from Rose Hill ES. If you would like to view the pictures, click on "View it as a Web page" after the page opens.
Rose Hill Players presents "Let the Games Begin"
Thank you to our STEAM teacher, Mr. Yannos Misitzis, for bringing in our guest, Danielle Wynne, to show and tell about ecological stewardship at Rose Hill!
Congratulations, Dawn Hendrick, the new principal of Rose Hill Elementary School!


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JR Construction offers much more then just HVAC.
We also offer 24/7 response to Floods in your home or place of business. We are well equiped to handle any job that you may need done. So give us a call and let us show you what we can do for you. Insurance claims are also welcome.


Home » art and design » Angela Bassett Smokes the SAG Awards Red Carpet in Georges Chakra + Kimberly McDonald!
If you saw "Black Panther", you would have seen Angela Bassett in a great role–that of the Queen Mother of Wakanda. She wore amazing costumes in that movie and she was truly a fashion statement along with the other actresses in the movie.
Bassett wore an amazing dress from Georges Chakra for the SAG awards and as a presenter!
Nominated for Outstanding Performance by a Cast in a Motion Picture for her role in Black Panther and presenting this evening, actress Angela Bassett looked radiant in a Georges Chakra grey sleeveless V-neck gown with 3-D chiffon cutouts, beaded detailing, and center slit from the 2018 Fall/Winter Couture Collection.
Runway model wearing this gown!
Love the boho chic-ness of this dress. Not everyone could pull this off. Bassett and her gorgeous hair make this outfit work – plus the addition of sparkling earrings and a great bag put the icing on the cake!
Double Geode Earrings with Diamonds by Kimberly McDonald!
Academy Award-nominated actress Angela Bassett wore Kimberly McDonald's One of a Kind Double Geode Earrings with Diamonds set in 18K White Gold with a Black Rhodium Finish while attending the Screen Actors Guild Awards.
Kimberly McDonald One of a Kind Double Geode Earrings with Diamonds set in 18K White Gold with a Black Rhodium Finish.These gorgeous earrings are simply stunning! They underscore the dress as well as Bassett's own unique style!
Angela Bassett complimented her look with a Tadashi Shoji's Ciara clutch, a silver crystal encrusted octagon shaped clutch.
The clutch shown is the bag in rose quartz. The one Bassett carried was in silver. This bag is available online!
Tadashi Shoji is a leading designer of elegant dresses, along with bridal, plus size evening dresses, dresses for mother of the bride and groom, cocktail dresses for weddings,accessories, shapewear, intimates, kids fashion and fragrance.


NOTES: The words "one, two, three, four, five,six, seven, all good children go to heaven" originate from an English nursery rhyme.
A teenage performer was asked to say these words and repeat them while being recorded in the privacy of his own company. The performer was instructed to speak the words as softly as possible while the microphone levels where as high as possible without causing feedback. The performer was asked to repeat the words as often as possible and in any manner or rhythm that made it possible to do so.
After the recording, the performer described a sense of uneasiness and drowsiness that came with the experience.
The work was installed in the existing studio situation, between 2 heating elements on a paint covered floor.
EXHIBITIONS: Group. Munch Studio, Olso, May 2015. Title: The Human Mountain (Towards The Light). Curator; Tony Christian Norum.


text:
Free Tools Boost 2020 Election Security, but Not Enough
Lily Hay Newman
More companies than ever are offering low-cost security services for election bureaus and campaigns. It's still not clear how much they'll actually help.
Photograph: Drew Angerer/Getty Images
Officials around the United States have spent the past three years scrambling to harden election and voting infrastructure against the disinformation campaigns, phishing attacks, and system probing that plagued 2016. With exactly one year to go until the 2020 presidential election, local and state boards of election have made significant progress on improving digital defenses. But researchers and election integrity advocates continue to sound the alarm that some of the most important changes—like replacing insecure voting machines and hiring necessary personnel—can't happen without more funding from Congress. And the scores of free cybersecurity offerings that have cropped up from tech companies to fill the void ultimately can't substitute for those resource-intensive projects.
Free and low-cost election cybersecurity tools are gaining visibility, though, as a way for small or underfunded election groups to make some meaningful improvements. They are particularly suited in some ways to aid campaigns, which are lightweight, temporary organizations by nature. But in addition to their limitations for dealing with deeper problems, it's unclear how widely these low-cost tools are adopted, perhaps in part because it's difficult to determine which offerings are safe and effective.
"I've heard election officials, in particular, say that they are bombarded with offers from private vendors to help with cybersecurity and often feel like they have no basis for determining who to trust," says Lawrence Norden, deputy director of the Brennan Center's Democracy Program at New York University School of Law.
Private vendors aren't the only option for election officials and candidates. Since 2016, the Department of Homeland Security, the US Election Assistance Commission, federal law enforcement, and other agencies have all been working to increase communication about election security threats and expand the defense programs and tools they offer. Nonprofit and academic organizations have also been working on campaign security and election integrity resources.
And there are a number of free services from well-known vendors, which can still be valuable. Some initiatives debuted ahead of the midterm elections to protect state and local government websites and services like online databases. One of the more popular company offerings is the Athenian Project from the internet infrastructure company Cloudflare. It debuted in late 2017 and stems from a similar suite of free protections, known as Project Galileo, that Cloudflare offers to human rights groups, activists, journalists, and artistic organizations. Today the Athenian Project is used by more than 110 jurisdictions in 25 states, including Alabama, Hawaii, North Carolina, and Rhode Island.
"A lot of what happens in the election space is about voter confidence, so the concern is that you don't want to have your website defaced or improperly accessed, because even if there's no change in vote count, it still undermines voter confidence," says Alissa Starzak, Cloudflare's head of policy. "And we're seeing instances where we've prevented those types of things. That doesn't mean there aren't still gaps and there aren't still challenges in the space, but I think that we are seeing progress."
Jigsaw, a division of Google's parent company Alphabet, runs a comparable initiative called Project Shield. Project Shield began taking on election-related clients in May 2018, focusing on campaigns in the US and Europe. Jigsaw CEO Jared Cohen emphasizes the organization's dedication to election defense through Project Shield and Google's Protect Your Election initiative, which also aims to combat disinformation. Jigsaw wouldn't say how many campaigns have taken advantage of its services or provide any specific statistics on its use in the political sphere, though.
Another tech giant, Microsoft, offers a number of election-related cybersecurity protections through a service known as AccountGuard. Launched in August 2018, it provides monitoring and intrusion protection for Microsoft accounts in Office 365, Outlook.com, Hotmail, and other platforms. Microsoft says that AccountGuard currently has about 60,000 enrolled accounts across political campaigns, parties, and democracy-focused NGOs in more than two dozen countries. And the service has generated more than 800 notifications to AccountGuard users of attacks against political campaigns, parties, and pro-democracy groups since last year.
Microsoft did not specify how much of that adoption is in the US, though. Publicly available internet infrastructure records known as Mail Exchange records indicate that the only two presidential campaigns that used Microsoft-provided email services in September were those of President Donald Trump and Mark Sanford.
Still, Microsoft has done a slew of important election threat research and can gather activity signals worldwide through the massive footprint of Windows. At the beginning of October, for example, the company warned that Iranian hackers had been targeting a presidential campaign, current and former US government officials, journalists, and Iranians living outside Iran with phishing attacks. Microsoft would not name the campaign, but it is widely reported to have been that of President Trump.
In addition to low-cost offerings from recognizable tech giants, security firms of various size and prominence have also announced election-related protections. Companies of all sizes seem to be constantly entering the increasingly crowded space.
Facebook, for example, just launched a special account-protection mechanism for candidates, elected officials, and their staff at the end of October. With a year to go before the 2020 election, there's still time for candidates to activate this and other services. But it's of course too soon to say how many actually will.
When it comes to defending campaigns specifically, low-cost offerings have also taken time to proliferate because of campaign finance restrictions on accepting gifts and free services. Area 1, a phishing defense firm, initially faced pushback from the Federal Election Commission earlier this year when it tried to offer discounted protections to campaigns. Eventually, though, the company demonstrated to the FEC that the offering is not specific to campaigns and is actually a general business practice offered to a number of small or under-resourced organizations. Area 1 says it now counts half of current presidential campaigns and a majority of congressional campaigns as clients along with some campaign committees and election-related nonprofits.
"Companies have tried to use election security as a marketing ploy, but it's mostly bluster, because they haven't committed to making their offerings useful or legal with the FEC," says Oren Falkowitz, CEO of Area 1 and a former NSA analyst, of competitors in the space. "The candidates are very concerned about their campaigns being phished. And we are observing daily phishing attacks against candidates—a mix of nation state and non–nation state groups. The risk of damages increases as candidates gain momentum, expand their staffs, and get closer to Election Day."
Some companies may inflate their impact or play a public relations game, but free services can genuinely benefit state and local election organizations and campaigns that might not otherwise have the institutional will to prioritize even basic cybersecurity protections. At the same time, though, with so many offerings now available and few quality controls in place, the task of finding and deploying resources may still be daunting. Campaigns and election organizations can still make cybersecurity improvements in the final year before Election Day. But even choosing the right free tool won't resolve the deeper, more expensive vulnerabilities still dogging US election infrastructure.
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👁 Prepare for the deepfake era of video; plus, check out the latest news on AI
🏃🏽♀ Want the best tools to get healthy? Check out our Gear team's picks for the best fitness trackers, running gear (including shoes and socks), and best headphones.-
Lily Hay Newman is a senior writer at WIRED focused on information security, digital privacy, and hacking. She previously worked as a technology reporter at Slate magazine and was the staff writer for Future Tense, a publication and project of Slate, the New America Foundation, and Arizona State University. Additionally... Read more
Winds are fueling the Kincade Fire
Buildings burn as the Kincade Fire moved through Geyserville, California. The fire has been fueled by high winds, buring over 10,000 acres in a matter of hours and prompting evacuations in the Geyserville area. Video by Justin Sullivan/Getty Images
TopicsELECTION 2020


Very cool Matt-- thanks for letting us know!
Pier B stream is down..Good luck and stay warm.
Pier B should be good now!
Love the rotating cam, Dennis!!! Thanks for another terrific view!
maybe the webcams were down due to the tragic event that took place Tue night-early Wed morning at the bridge. Wow! so sad!!
I'd just read an article in today's Duluth News Tribune that someone had commit suicide by jumping off the Aerial Lift Bridge on Wednesday Evening: http://www.duluthnewstribune.com/news/man-dies-after-jumping-aerial-lift-bridge-3631600. I was wondering if the Visitor Center camera had capture the incident last night.
Yes, a tragedy indeed. While there may be some footage, I do not plan on making any public. I am so sorry for the family.
Is the video of Bentleyville still available to be viewed, if so where do we find it? Want to share it with others who were not aware of it. A lot of preparation, work of many people to make such a beautiful display for the Christmas season. Thanks everyone as we viewed it the other day from Huron, SD.
Love the new panning camera....it's good to be able to see what the entire harbor is like. Thank you again, Mr. O'Hara for your diligence!
Thank you, Dennis, for not making footage from the other night public. It was a horrible tragedy, not meant to be exploited or viewed again. Your restraint is appreciated by many, and our prayers go out to the family of the young man.
I was looking through the Duluth News Tribune obits for an old Central High classmate when I found the young fellow's listing. He was a good kid, brought tears to my eyes to read it! My condolences to the family.


Are you ready for ROUND 6 of the Iron Crafter?!?
The secret ingredient for this round is.... Sweaters!
You could use part of it or all of it! We think that this could be really fun for fall! I am so excited to see what you all come up with!
Now let's see what you've got!
Thanks so much for hosting!! I was SOOOO excited when I saw the secret ingredient. My mom gave me 2 huge trash bags full of her old sweaters about a month ago and I have been furiously working at re-purposing them ever since. I was hard to chose what to link up! I can't wait to see what everyone else does!
Hi! Your post says that this round will be open from Oct. 25 - 29, but that it's open two weeks. Am I missing something?
Woo hoo! Sweaters as the secreat ingredient . . . there are going to be some incredible projects linked up for this one. Mandy is going to have a very difficult job!
Thanks for clarifying that it was ok to link up s few!
@ Mel P-I think that was the announcement from a while ago, meaning that the two week time frame was from the date the secret ingredient was announced, not from today.
such cute stuff already! can't wait to see more!
Love you guys; get ready -- here's a big WAVE from Cape Cod!
I was able to add my Recycled Sweater Scarf & Mittens, but for some reason, can't link my Blue Blazin' Bag with a recycled sweater for the lining. If you can, link me up! If not, OH well! Thanks!


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Apple Leads as Global Wearables Shipments Grow 9.9 Percent in Q3 2021: IDC
December 7, 2021 by admin 0 Comments
Apple captured the top position as global shipments for wearables grew 9.9 percent year-on-year (YoY) during the third quarter of 2021 (3Q21) reaching a total of 138.4 million units, according to a new report by the International Data Corporation (IDC). The wearables category includes true wireless stereo (TWS) earphones as well as wrist-worn wearables like fitness bands and smartwatches. The market research firm also says that the demand for smartwatches has increased as compared to wristbands owing to the narrowing gap in their pricing.
As per IDC's Worldwide Quarterly Wearable Device Tracker, the hearables led the growth as the category grew 26.5 percent on a year over year (YoY) basis and accounted for 64.7 percent of wearable device shipments. Wrist-worn wearables captured 34.7 percent of the market, IDC says. Apple and Huawei tied for first place in the wrist-worn segment dethroning Xiaomi in 3Q21 which relied on wristbands but consumer preferred watches.
"Demand has been slowly shifting away from wristbands towards watches as consumers increasingly want a more capable device and as the gap in pricing narrows," said Jitesh Ubrani, research manager for IDC Mobility and Consumer Device Trackers. He says that the number of watches sold for under $100 (roughly Rs. 7,500) is now equal to wristbands, which have dominated this price band in the past. "While the entire wrist-worn wearable market declined YoY, the market for watches actually grew 4.3 percent," added Ramon T. Llamas, research director for IDC's Wearables Team.
On category-wise distribution, Ubrani says that Indian and Chinese brands grew due to low-end watches while "Apple, Huawei, and Samsung maintain a hold at the high-end". Meanwhile, Llamas further dissected into the category saying that "even as smartwatches have been very popular, it's the other watches – including kids' watches, exercise watches, hybrid watches, and others – that drove the market.
Top wearable brands in Q3 2021
As mentioned, Apple captured the top position despite a 35.3 percent decline in Apple Watch shipments in 3Q21. Hearables from Beats and AirPods helped the company lead in the wearables market. Samsung got the second spot (13.8 percent growth) due to the good reception of the Galaxy Watch 4 Series smartwatches that run Google's Wear OS. Xiaomi's shipments fell 23.8 percent during the quarter owing to wrist-worn wearables, however, in the hearables category the company continued to offer extremely low-cost options.
Huawei grew with the help of its hearables business as wristbands and watches combined declined 5 percent during Q3 2021. The fifth spot was grabbed by Indian company Imagine Marketing, which is behind the brand Boat. The company offered low-cost products and did "relentless marketing" that helped it drive volume.
Deals on Popular Premium Graphics Cards for You to Consider
WhatsApp Starts Rolling Out Global Voice Message Player for Beta Testers on iOS
Microsoft Teams Gets 5 New Features to Support Frontline Workers


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Council's Assembly Rooms demolition plans in ruins
The decline of S&A Foods, and Perween Warsi's loans
Derby News Comment
New owners of Sinfin Moor Social Club will re-open after extensive refurbishment
By Russell Pollard on May 18, 2020 • ( Leave a comment )
Towards the end of 2019, concern was raised in Sinfin that there were plans to convert the local Social Club into a Sikh Gurdwara. The locals were most worried about the loss of this valuable amenity which was available to all.
The view of the wider Sikh community was that it was not necessary, given the 4 already in the Normanton area; it was also felt by them that this initiative was being pursued for the wrong reasons. This was covered in my previous article "Sinfin Moor Social Club : Sikh Gurdwara for Tory votes?"
Subsequently, one of the shareholders of the club intervened, and ensured that the Club was saved from the change of use "Sinfin Moor Social Club saved by local resident and shareholder Sanjeev Chopra"
Further developments, now means that the Sinfin Moor Social Club will soon have new owners who intend to open it and start trading as soon as possible. They will be carrying out comprehensive works to ensure it has a prosperous future and create a vibrant local facility for the residents of Sinfin and Stenson Fields.
Sohan Perdesi is purchasing the lease and will be operating the social club with his sons. It was their local before it closed. The family's main intention is to leave it as a social club and to reinvigorate it and meet the community's needs.
Previously Sohan purchased, refurbished and operated the Queens Hall with his son Rick on London Road.
The immediate plans for the club are;
Refresh the exterior by introducing new signage and lighting
Extend and install a new kitchen with the intention of serving hot and cold food in the near future
Installing new beer lines, coolers and pumps throughout
Re-starting the Pool, Snooker, Darts & Football Teams – And more if the community wants
Creating a family atmosphere for all to enjoy
The banqueting suite is dilapidated and requires a major refurbishment; this will be done to a high specification, as he did with the Queens Hall. The refurbishment will include
Full draping to create welcoming room
Full LED Lighting
Fully Air Condition the room so its comfortable in all seasons
This is with a view to holding large events such as; Charity Events, Comedy Nights, Christmas Parties and Celebrity Meet & Greets as well as to be available for Private Functions.
Sohan said
"I am really looking forward to getting the Club open and running. I have been a regular in the club for many years and I can see it has huge potential. I'd like to thank Sanj Chopra for saving the club. Now it's time to get it re-opened for the whole community to use as a Social Club, we will keep the community updated and will open up as soon as we safely can"
Categories: Derby News Comment
Tagged as: Sinfin Moor
Covid-19 – superficial headline statistics miss the important sex story
Children First Derby receives the Queen's Award for Voluntary Service


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redpajama_set_name: RedPajamaGithub


I Wonder Why They Don't All Do That? Oh, Wait . . . They Do!
I just saw a political ad and the guy must be honest because it said so on his label, right?
Posted in Thoughts Profound and Otherwise | Comments Off on I Wonder Why They Don't All Do That? Oh, Wait . . . They Do!
– A depressingly exaggerated mocking of a political ad I saw today, depressing because I'm not exaggerating by nearly enough for my comfort.
Posted in Thoughts Profound and Otherwise | Comments Off on Really?
This will no doubt come as a shock to you, but my toddler has precisely zero interest in your political aspirations, so perhaps the portion of your over-bloated campaign budget you used to constantly interrupt his Thomas the Tank Engine videos on YouTube with the same ad over and over again might have been better spent.
Yes, I'm talking to both of you.
Please show greater courtesy and better sense in your future endeavours, be they presidential or otherwise.


Leading a healthy lifestyle involves eating foods high in nutrients while avoiding empty, or suboptimal, calories. In order to identify the most nutrient dense foods, we must look for foods highest in essential nutrients while being lowest in calories.
Vitamins: Vitamins A, B1 (Thiamin), B2 (Riboflavin), B3 (Niacin), B5 (Pantothenic Acid), B6, B9, B12, C, D, E, and K.
All these nutrients added together created a new nutrient density metric that we call "Total Daily Value" or "Total DV". Some methodologies might suggest subtracting saturated fat, cholesterol, and sodium as these are generally seen as "bad" nutrients. However, since some people now favor consumption of saturated fat and cholesterol, they were left in. Sodium was also included since processed foods will not be in the list, so only natural sodium will be counted, and sodium levels found naturally in foods are typically low enough to be healthy.
Below are 15 of the most nutrient dense foods, these include fresh herbs like parsley, and dark leafy greens like swiss chard, kale, and spinach. Also on the list are shellfish (oysters), organ meats (liver), mushrooms, peppers, green onions, broccoli, and carrots. For even more high nutrient foods see the extended list of less common foods rich in nutrients.
Nutrition Facts for Swiss Chard.
Nutrition Facts for Cooked Kale.
Nutrition Facts for Cooked Mustard Greens.
Nutrition Facts for Canned Eastern Oysters.
Nutrition Facts for Pan Fried Beef Liver.
Mushrooms exposed to light will have much higher levels of vitamin D.
Nutrition Facts for Raw Crimini Mushrooms (Exposed To Sunlight Or UV).
Nutrition Facts for Sweet Yellow Peppers.
Nutrition Facts for Spring Onions.


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No Episodes Available
When Emily Thorne moves to the Hamptons, everyone wonders about the new girl, but she knows everything about them, including what they did to her family. Years ago, they took everything from her. Now, one by one, she's going to make them pay.
Director: Mike Kelley
Actors: Ashley Madekwe, Barry Sloane, Christa B. Allen, Christa Brittany Allen, Connor Paolo, Emily VanCamp, Gabriel Mann, Henry Czerny, James Tupper, Josh Bowman, Joshua Bowman, Karine Vanasse, Madeleine Stowe, Nick Wechsler
Networks: ABC
Missing Nine
Story about an unexpected plane crash that causes a widespread panic in South Korea due to the disappearance of nine people, including some influential figures in the entertainment industry. Seo…
Genre: Adventure, Comedy, Drama, Mystery
An insecure but courageous and intelligent teen named Peter Parker, a new student of Midtown High, is bitten by a radioactive spider and given powers. He becomes a hero named…
Genre: Action, Adventure, Animation, Family, Sci-Fi, Sci-Fi & Fantasy
The story of Victorian serial killer Mary Ann Cotton, a poisoner whose methods leave no visible scars, allowing her tally of victims to mount, unsuspected by a Victorian society unable…
Genre: Crime, Drama, History, Mystery, Thriller
A demented serial killer taunts a retired police detective with a series of lurid letters and emails, forcing the ex-cop to undertake a private, and potentially felonious, crusade to bring…
The American version of the British "Strictly Come Dancing" show sees celebrities perform choreographed dance routines which are judged by a panel of renowned ballroom experts and voted on by…
Genre: Family, Game-Show, Music, Reality-TV
Larva Island
Stranded on a tropical island, two silly larva buddies find slapstick fun in everything from discovering food to meeting new animal friends.
FBI Special Agent Olivia Dunham, brilliant but formerly institutionalized scientist Walter Bishop and his scheming, reluctant son Peter uncover a deadly mystery involving a series of unbelievable events and realize…
Genre: Drama, Mystery, Sci-Fi, Sci-Fi & Fantasy, Thriller
Unlocking the Truth
Love, lust, murder, mystery, suspense…all the makings of a great dramatic story. The catch? It's not a fictional story. It's real life. This serialized documentary series follows the journey of…
Genre: Crime, Documentary
Totally Spies!
Totally Spies! depicts three girlfriends 'with an attitude' who have to cope with their daily lives at high school as well as the unpredictable pressures of international espionage. They confront…
Country: Canada, France, South Korea, USA
Genre: Action, Adventure, Animation, Comedy, Drama, Kids, Mystery
An anthology series centered around some of history's most famous criminals.
Dragon Tales is an American-Canadian animated pre-school children's television series created by Jim Coane and Ron Rodecker and developed by Coane, Wesley Eure, Jeffrey Scott, Cliff Ruby and Elana Lesser….
Genre: Animation, Sci-Fi & Fantasy
Galactik Football is a french animated television series, co-produced by Alphanim, France 2, Jetix Europe, and Welkin-Animation. Its third 26-episode season aired in Europe in June 2010. In the universe…
Genre: Action, Animation, Comedy, Drama, Sci-Fi, Sci-Fi & Fantasy, Sport


Driving Zone 2 – street racing on android, with excellent graphics and exciting gameplay. In this game you will be able to choose from a variety of cars from urban to beautiful business sedans and powerful sports cars. Choose your car from the game and drive through a huge open world with unpredictable crossings and dangerous turns. Also you will be pleased with the unlimited possibilities of tuning the car, which will allow you to change the car both visually and technically. Come to the finish line first ahead of your rivals and earn points, performing dangerous overtaking and passing on the red traffic light. Create your own unique driving style and improve your car after every race.


Boring but important. The title of this post is the answer to the question "Why the olympics didn't melt the internet" Apparently sports fans world wide have been enjoying high quality video of the olympics delivered to their computers by the internet.
This is in contrast to the usual experience of chunky graphics and long pauses I usually get when watching video on my computer.


The lodges in Corsica offers a stop on a hiking trail in a village or hamlet, still in a protected environment, rich natural and cultural heritage. It has everything a traveler needs after a day of walking: Shower, sleeping in dormitories or in the room, catering.
Rates quoted are indicative average prices per day per person.


13/01/2019 · https://foxyhacks.com/pokemongo/ How to Get Unlimited Heart Scales in Pokemon Sun and Moon! How to go on a Date with OLIVIA!] //pokemon go gym status map,... Happy New Year! I bought a brand new Pokemon Ultra Moon a few weeks ago but am selling it cause I don't really like the game story. Everything works perfectly, and the original case and instruction pamphlet are included.
7/05/2018 · Pokémon Ultra Moon, in terms of content and story, sits midway through being a third version, due to how similar it is to its predecessor, and a full on remake, although it offers no visual upgrade and comes out barely 12 months after its predecessor.... 17/11/2017 · Pokémon Ultra Sun and Ultra Moon are less like new games in the RPG franchise, and more like definitive remakes of last year's Pokémon Sun and Moon.
I played Moon when it first came out, I figured might as well get Ulta Moon too. I feel like this is everything Game Freak/Nintendo wanted to do with the original Sun and Moon games, but they just ran out of time. Overall the story is pretty similar to the original Moon with the exception of adding in the Ultra Recon Squad or whatever it was called. Anyways, they revamped some tracks and pokemon emerald how to get celebi and jirachi Sun and Moon will get you up to speed on everything you need to know, so you can go back to the older generations and be a pro trainer. If you're an longtime player, these games get rid of a lot of headache that the previous ones had. Quality of life is much, much better.
What Pokémon GO promo codes look like? It's unclear at this moment, as the feature hasn't been officially released yet. The equivalent codes for Ingress are fairly long and cryptic: xhtz7hny1777rffd.
4/01/2018 · Pokémon Supernova Sun and Penumbra Moon are mods for Pokémon Ultra Sun and Ultra Moon. Like my Rutile Ruby & Star Sapphire hacks and my Nova Sun & Umbra Moon hacks, their main purpose is to provide a more challenging game experience while not artificially limiting the player.


This is Cipto Junaedy Strategy Instagram Profile (@ciptojunaedystrategy). Here you can discover all stories, photos, videos posted by Cipto Junaedy Strategy on Instagram Profile.
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Elections News
Pro-Life Susan B. Anthony list endorses Jessica Taylor
Sessions denounces Jones' support for Pelosi's withholding articles of impeachment
Byrne calls Kaepernick a jerk, suggests he is un-American
Barry Moore defends Trump for assassination of Iranian general
Republican Senate candidates praise "good guy with gun" in Texas church shooting
Thursday, U.S. Senate candidate Stanley Adair released a statement hitting the early frontrunners in the race for the Republican nomination for the Senate seat currently held by Doug Jones (D).
Adair was asked to comment on polling showing former Attorney General Jeff Sessions, former Auburn football coach Tommy Tuberville, and Congressman Bradley Byrne all leading Jones if the race were held when the poll was taken in late December.
"Polls don't always tell the true story and they certainly don't always pick the best Candidates," Adair said. "I am not impressed with Mr. Session and I am not alone."
Sessions held this Senate seat from 1997 to 2017, when he vacated after he was confirmed as U.S. Attorney General.
"He is not entitled to this seat," Adair charged. "Sessions had his opportunity. I believe in term limits. The time is now for Alabama to move forward and not repeat the errors of the past."
Adair was also critical of Tuberville.
"As for "The Coach," his record should speak for itself with early contract buy-outs and leaving recruits sitting at the table to take another job?" Adair said. "A Senator, must respect all Alabamians and extend a hand to all and its doesn't appear the coach understands this with his recent comments!"
Adair drew headlines this fall when praised President Donald J. Trump (R), saying that he should go down as one of the greatest presidents ever. "Mr. Trump is a great President and should go down as one of the greatest Presidents ever for the people."
Adair has also criticized Byrne in previous comments.
"The Alabama voters are smart and know that we need change not another sellout," Adair added. "Mr. Byrne is part of the least approval rated Congress in our Nation's history, at or near thirteen percent. This should tell you something about the way the Alabama voters and the rest of the Country is feeling about our career Politicians. Mr. Byrne was one of the first members of Congress to ask President Trump to step down and now claims he supports the President ninety seven percent of the time. I don't think him being in the skybox signals an endorsement. This is just my opinion, but the President will wait until after the primary to endorse a Candidate. I enter this race to give the Alabama voters a clear choice, a businessman or just another career Politician. These politicians don't get it! Voters want someone that will stand with the President and say enough is enough and fight for them."
The poll by JMC Analytics had Sessions, Tuberville, and Byrne all leading Doug Jones in a head to head matchup by five, seven, and four points respectively. In the polling 13, 13, and 16 percent said that they were still undecided. Jones however held a lead over former Chief Justice Roy Moore of 47 to 33 with 20 percent undecided. Jones also led State Representative Arnold Mooney 40 to 34 with 25 percent undecided. The pollster did not query voters on an Adair versus Jones matchup.
Adair is a businessman and former televangelist. He is a lifelong native of Northwest Alabama and emphasizes hard work in his campaign. He began his career as a furniture assembly line worker and after learning the craft, would later go on to build Adair Furniture Inc. Adair says that he has always worked hard to bring jobs to Northwest Alabama. Adair has engaged in many businesses from a restaurant to a TV station. In early 2000's he hosted a television show on DIRECTV and dish networks.
Adair is running in a crowded Republican field that also includes: Ruth Page Nelson.
The Republican primary is March 3.
To read the full poll results here.
Related Topics:Congressman Bradley ByrneDoug Jonesformer Attorney General Jeff SessionsRepublican nominationseatTommy TubervilleU.S. Senate candidate Stanley Adair
Kiani Gardner opposes tariffs on European goods
Doug Jones introduces bill to help diagnose, save lives of children with rare diseases


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Diagnosis & treatment >
Adult brain tumour types >
<Glioblastoma >
Glioblastoma research
Targeting glioblastoma cell metabolism
Title: Exploiting passenger synthetic lethality for the treatment of aggressive glioblastomas
Lead Researchers: Dr Vincenzo D'Angiolella
Where: Oxford Institute for Radiation Oncology
When: Feb 2019 – Jan 2021
Cost: £120,000 over a 2 year period
Research type: Adult, Glioblastoma (High Grade), Academic, Expanding Theories
What is the purpose of this study?
This grant aims to explore and target the increased metabolism of glioblastoma (GBM) cells which allow them to grow so quickly. In normal, healthy cells a lot of genes can cause metabolism to increase or decrease, speeding up or slowing down the cell's growth. In all cancers there are metabolic genes lost called tumour suppressors which would normally slow growth. In GBM specifically, a gene called MTAP has been lost along with the tumour suppressors. This loss of MTAP is key to this project because it makes the GBM cells different to normal cells in a way that the researchers can target. In the absence of MTAP, tumour cells have to rely on alternative methods to survive.
Do the siRNAs stop GBM growth?
The first aim of this project is to grow GBM cells, which are missing MTAP, in the lab. The team will then test chemicals called siRNAs which should block the alternative pathways and see if the cells die. To confirm that these drugs will only harm GBM cells, and not normal brain cells, the scientists will then cause the cells to start making MTAP again, and they should be resistant to the drug.
How do the siRNAs work?
Following on from the work in Aim 1, the second part of the grant is to look at what specific changes the siRNAs cause in the cells. The team will look at levels of different metabolites to see how the siRNAs are stopping GBM growth.
Glioblastomas are the most common and aggressive types of brain cancer found in adults. The current standard treatment involves surgery to remove as much of the tumour as possible, followed by radiotherapy and chemotherapy. Despite aggressive treatment, tumour recurrence is often inevitable, highlighting the urgent need to understand why these treatments are failing.
This research project will help to improve our knowledge of the differences between healthy brain tissue and tumour cells. It will help us better understand the underlying mechanisms driving aggressive glioblastomas, and identify ways in which we can disrupt these interactions with drugs to slow tumour growth. GBMs lacking the MTAP gene represent a subset of tumours with significantly poor survival. So it's a priority to identify novel targets in this subset. The test for the presence or absence of MTAP in GBM could become an important biomarker test for these patients, and potentially steer the type of treatment people receive in the future.
Importantly, the research will also test how the drugs are working in the lab. Unfortunately a large number of drugs that work in the lab are not effective in the clinic. By understanding how the siRNA is changing the GBM cells, new drugs could be developed sooner by expanding on this knowledge.
Who will it help?
This research has the potential to help anyone with a glioblastoma which does not have MTAP. It could provide a new test to help clinicians predict the prognosis of their patients, and could even provide a new class of drugs to use to defeat GBM.
Understanding the biological mechanisms underlying the weakness of cancer cells will help to properly translate the approach to the clinic and suggest potential mechanisms of resistance to therapy.
Dr Vincenzo D'Angiolella
When this grant starts in early 2019, the first aims will be to grow GBM cells that lack MTAP and then test the siRNA to stop growth. Next, they will assess the cells to find out what the siRNA is changing which leads to cell death.
Research is just one other way your regular gift can make a difference
Research is the only way we will discover kinder, more effective treatments and, ultimately, stamp out brain tumours – for good! However, brain tumours are complex and research in to them takes a great deal of time and money.
Across the UK, over 100,000 families are facing the overwhelming diagnosis of a brain tumour and it is only through the generosity of people like you can we continue to help them.
But, by setting up a regular gift – as little as £2 per month - you can ensure that families no longer face this destructive disease.
What is glioblastoma?
Treating glioblastoma
5-ALA: The pink drink
What is an adaptive clinical trial?