text:
Leukotriene enhanced allergic lung inflammation through induction of chemokine production
Kihyuk Shin, Jung Joo Hwang, Bo In Kwon, Farrah Kheradmand, David Corry, Seung Hyo Lee
The leukotrienes (LTs) enhance allergen- and interleukin (IL)-13-dependent allergic lung inflammatory disease. However, the precise requirement of LTs and the mechanism by which they elicit allergic lung responses remain uncertain. To clarify the involvement of LTs in respiratory allergen- and IL-13-induced experimental asthma and elucidate the underlying mechanisms of LTs-mediated enhanced allergic asthma, we investigated the role of LTs in two models of allergic inflammation: intranasal Aspergillus protease allergen and recombinant IL-13-induced T helper type 2 (Th2) cell-mediated inflammation, and also examined Th2-related chemokines downstream of LTs signaling. 5-Lipoxygenase (5-LO)-deficient mice exposed to short-term intranasal Aspergillus protease allergen showed attenuated airway inflammation, decreased airway hyper-responsiveness and reduced bronchoalveolar eosinophilia when compared to wild-type mice. However, this phenotype was less apparent using long exposure to the same allergen. 5-LO-deficient mice exposed to intranasal rIL-13 also showed attenuated phenotypes of allergic asthma via significant reduction in Th2-specific chemokines, CCL7 and CCL17 production and decreased Th2 cells recruitment to the lungs. Addition of leukotriene B4 (LTB4) and LTC4 to the airways of 5-LO-deficient mice resulted in the rescue of rIL-13-induced experimental asthma. Furthermore, LTs addition to rIL-13 synergistically enhanced the production of Th2-specific chemokines in the lung and inflammatory responses. Therefore, our findings suggest that LTs complement allergens and their downstream cytokine (e.g., IL-13) induced Th2 inflammation by enhancing the induction of Th2 chemokines.
Clinical and Experimental Medicine
Published - Aug 3 2015
Interleukin-13 (IL-13)
Leukotrienes (LTs)
Lung inflammation
Dive into the research topics of 'Leukotriene enhanced allergic lung inflammation through induction of chemokine production'. Together they form a unique fingerprint.
Leukotriene Chemistry 100%
Leukotrienes Medicine & Life Sciences 91%
Chemokines Medicine & Life Sciences 70%
Pneumonia Medicine & Life Sciences 60%
Allergen Chemistry 53%
Allergens Medicine & Life Sciences 53%
Intranasal Chemistry 51%
Shin, K., Hwang, J. J., Kwon, B. I., Kheradmand, F., Corry, D., & Lee, S. H. (2015). Leukotriene enhanced allergic lung inflammation through induction of chemokine production. Clinical and Experimental Medicine, 15(3), 233-244. https://doi.org/10.1007/s10238-014-0292-7
Leukotriene enhanced allergic lung inflammation through induction of chemokine production. / Shin, Kihyuk; Hwang, Jung Joo; Kwon, Bo In et al.
In: Clinical and Experimental Medicine, Vol. 15, No. 3, 03.08.2015, p. 233-244.
Shin, K, Hwang, JJ, Kwon, BI, Kheradmand, F, Corry, D & Lee, SH 2015, 'Leukotriene enhanced allergic lung inflammation through induction of chemokine production', Clinical and Experimental Medicine, vol. 15, no. 3, pp. 233-244. https://doi.org/10.1007/s10238-014-0292-7
Shin K, Hwang JJ, Kwon BI, Kheradmand F, Corry D, Lee SH. Leukotriene enhanced allergic lung inflammation through induction of chemokine production. Clinical and Experimental Medicine. 2015 Aug 3;15(3):233-244. https://doi.org/10.1007/s10238-014-0292-7
Shin, Kihyuk ; Hwang, Jung Joo ; Kwon, Bo In et al. / Leukotriene enhanced allergic lung inflammation through induction of chemokine production. In: Clinical and Experimental Medicine. 2015 ; Vol. 15, No. 3. pp. 233-244.
@article{2ae5e72afdc2485285c67238cace8116,
title = "Leukotriene enhanced allergic lung inflammation through induction of chemokine production",
abstract = "The leukotrienes (LTs) enhance allergen- and interleukin (IL)-13-dependent allergic lung inflammatory disease. However, the precise requirement of LTs and the mechanism by which they elicit allergic lung responses remain uncertain. To clarify the involvement of LTs in respiratory allergen- and IL-13-induced experimental asthma and elucidate the underlying mechanisms of LTs-mediated enhanced allergic asthma, we investigated the role of LTs in two models of allergic inflammation: intranasal Aspergillus protease allergen and recombinant IL-13-induced T helper type 2 (Th2) cell-mediated inflammation, and also examined Th2-related chemokines downstream of LTs signaling. 5-Lipoxygenase (5-LO)-deficient mice exposed to short-term intranasal Aspergillus protease allergen showed attenuated airway inflammation, decreased airway hyper-responsiveness and reduced bronchoalveolar eosinophilia when compared to wild-type mice. However, this phenotype was less apparent using long exposure to the same allergen. 5-LO-deficient mice exposed to intranasal rIL-13 also showed attenuated phenotypes of allergic asthma via significant reduction in Th2-specific chemokines, CCL7 and CCL17 production and decreased Th2 cells recruitment to the lungs. Addition of leukotriene B4 (LTB4) and LTC4 to the airways of 5-LO-deficient mice resulted in the rescue of rIL-13-induced experimental asthma. Furthermore, LTs addition to rIL-13 synergistically enhanced the production of Th2-specific chemokines in the lung and inflammatory responses. Therefore, our findings suggest that LTs complement allergens and their downstream cytokine (e.g., IL-13) induced Th2 inflammation by enhancing the induction of Th2 chemokines.",
keywords = "Chemokines, Interleukin-13 (IL-13), Leukotrienes (LTs), Lung inflammation",
author = "Kihyuk Shin and Hwang, {Jung Joo} and Kwon, {Bo In} and Farrah Kheradmand and David Corry and Lee, {Seung Hyo}",
note = "Funding Information: We thank Jie Xu, Yuping Qian, Seang-Hwan Jung, Sang-Young Lee and Eun-Hye Choi for technical assistance, and all the members of the Hye Hwa Forum for helpful comments on the manuscript. This study was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MEST, 2012M3A9C7050093), a grant of the Korea Healthcare technology R&D Project, Ministry for Health, Welfare & Family Affairs, the Republic of Korea (A101284), the KAIST Future Systems Healthcare Project from the Ministry of Science, ICT and Future Planning, and Eulji University in 2008. Publisher Copyright: {\textcopyright} 2014, Springer-Verlag Italia. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",
journal = "Clinical and Experimental Medicine",
publisher = "Springer-Verlag Italia",
T1 - Leukotriene enhanced allergic lung inflammation through induction of chemokine production
AU - Shin, Kihyuk
AU - Hwang, Jung Joo
AU - Kwon, Bo In
AU - Kheradmand, Farrah
AU - Corry, David
AU - Lee, Seung Hyo
N1 - Funding Information: We thank Jie Xu, Yuping Qian, Seang-Hwan Jung, Sang-Young Lee and Eun-Hye Choi for technical assistance, and all the members of the Hye Hwa Forum for helpful comments on the manuscript. This study was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MEST, 2012M3A9C7050093), a grant of the Korea Healthcare technology R&D Project, Ministry for Health, Welfare & Family Affairs, the Republic of Korea (A101284), the KAIST Future Systems Healthcare Project from the Ministry of Science, ICT and Future Planning, and Eulji University in 2008. Publisher Copyright: © 2014, Springer-Verlag Italia. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.
N2 - The leukotrienes (LTs) enhance allergen- and interleukin (IL)-13-dependent allergic lung inflammatory disease. However, the precise requirement of LTs and the mechanism by which they elicit allergic lung responses remain uncertain. To clarify the involvement of LTs in respiratory allergen- and IL-13-induced experimental asthma and elucidate the underlying mechanisms of LTs-mediated enhanced allergic asthma, we investigated the role of LTs in two models of allergic inflammation: intranasal Aspergillus protease allergen and recombinant IL-13-induced T helper type 2 (Th2) cell-mediated inflammation, and also examined Th2-related chemokines downstream of LTs signaling. 5-Lipoxygenase (5-LO)-deficient mice exposed to short-term intranasal Aspergillus protease allergen showed attenuated airway inflammation, decreased airway hyper-responsiveness and reduced bronchoalveolar eosinophilia when compared to wild-type mice. However, this phenotype was less apparent using long exposure to the same allergen. 5-LO-deficient mice exposed to intranasal rIL-13 also showed attenuated phenotypes of allergic asthma via significant reduction in Th2-specific chemokines, CCL7 and CCL17 production and decreased Th2 cells recruitment to the lungs. Addition of leukotriene B4 (LTB4) and LTC4 to the airways of 5-LO-deficient mice resulted in the rescue of rIL-13-induced experimental asthma. Furthermore, LTs addition to rIL-13 synergistically enhanced the production of Th2-specific chemokines in the lung and inflammatory responses. Therefore, our findings suggest that LTs complement allergens and their downstream cytokine (e.g., IL-13) induced Th2 inflammation by enhancing the induction of Th2 chemokines.
AB - The leukotrienes (LTs) enhance allergen- and interleukin (IL)-13-dependent allergic lung inflammatory disease. However, the precise requirement of LTs and the mechanism by which they elicit allergic lung responses remain uncertain. To clarify the involvement of LTs in respiratory allergen- and IL-13-induced experimental asthma and elucidate the underlying mechanisms of LTs-mediated enhanced allergic asthma, we investigated the role of LTs in two models of allergic inflammation: intranasal Aspergillus protease allergen and recombinant IL-13-induced T helper type 2 (Th2) cell-mediated inflammation, and also examined Th2-related chemokines downstream of LTs signaling. 5-Lipoxygenase (5-LO)-deficient mice exposed to short-term intranasal Aspergillus protease allergen showed attenuated airway inflammation, decreased airway hyper-responsiveness and reduced bronchoalveolar eosinophilia when compared to wild-type mice. However, this phenotype was less apparent using long exposure to the same allergen. 5-LO-deficient mice exposed to intranasal rIL-13 also showed attenuated phenotypes of allergic asthma via significant reduction in Th2-specific chemokines, CCL7 and CCL17 production and decreased Th2 cells recruitment to the lungs. Addition of leukotriene B4 (LTB4) and LTC4 to the airways of 5-LO-deficient mice resulted in the rescue of rIL-13-induced experimental asthma. Furthermore, LTs addition to rIL-13 synergistically enhanced the production of Th2-specific chemokines in the lung and inflammatory responses. Therefore, our findings suggest that LTs complement allergens and their downstream cytokine (e.g., IL-13) induced Th2 inflammation by enhancing the induction of Th2 chemokines.
KW - Chemokines
KW - Interleukin-13 (IL-13)
KW - Leukotrienes (LTs)
KW - Lung inflammation
JO - Clinical and Experimental Medicine
JF - Clinical and Experimental Medicine


text:
Clin Infect Dis. 1993 Feb;16(2):237-46.
Meningococcal disease in The Netherlands, 1958-1990: a steady increase in the incidence since 1982 partially caused by new serotypes and subtypes of Neisseria meningitidis.
Scholten RJ1, Bijlmer HA, Poolman JT, Kuipers B, Caugant DA, Van Alphen L, Dankert J, Valkenburg HA.
Institute for Research in Extramural Medicine, Vrije Universiteit, Amsterdam, The Netherlands.
In order to explain a threefold increase in the incidence of meningococcal disease in the Netherlands during the 1980s, we serotyped and subtyped Neisseria meningitidis isolates recovered between 1958 and 1990 from > 3,000 patients with systemic disease. No single strain could be held responsible for the increase. Apart from the newly introduced strain B:4:P1.4, which became the most prevalent phenotype in 1990 (21% of all isolates), the majority of the cases in 1990 were caused by many different strains that were already present in the Netherlands before 1980. For the period 1980-1990, a shift in the age distribution of patients with meningococcal disease from younger to older age categories was found, particularly with regard to cases due to meningococci of serogroup B; this shift is explained by the changing distribution of serotypes and subtypes within serogroup B. A polyvalent group B, class 1 outer-membrane-protein vaccine of a stable composition could theoretically have prevented approximately 80% of all group B meningococcal infections in the Netherlands during the past 30 years.
10.1093/clind/16.2.237
Bacterial Typing Techniques
Meningitis, Meningococcal/epidemiology*
Meningitis, Meningococcal/microbiology
Neisseria meningitidis/classification*
Netherlands/epidemiology
Seroepidemiologic Studies
Serotyping
Neisseria meningitidis - Genetic Alliance

redpajama_set_name: RedPajamaCommonCrawl


text:
História e estatísticas do Sporting Clube de Portugal nas competições da UEFA.

Taça dos Clubes Vencedores de Taças de 1963–64
A Taça dos Vencedores de Taças de 1963–64, ou simplesmente Taça das Taças, foi vencida pelo Sporting Clube de Portugal de Portugal, que derrotou o MTK Budapest da Hungria na final. Foi a primeira e única vez que uma equipa portuguesa ganhou um troféu da Taça das Taças.

O Sporting CP entrou na competição para derrotar a Atalanta na pré-eliminatória, o passado APOEL foi para a história de maior vitória nas competições da UEFA por 16-1, Manchester United, Olympique Lyonnais e na final derrotou o MTK Budapeste, a mesma final que foi disputada a duas mãos em solo neutro. O Sporting Clube de Portugal conquistou o seu primeiro e último título europeu até aos dias de hoje.

Honras

 Taça dos Clubes Vencedores de Taças
 Vencedores (1): 1963–64
 Taça UEFA
 Vice-campeão (1): 2004–05

Finais

Referências

Sporting Clube de Portugal

redpajama_set_name: RedPajamaWikipedia


At DumpsterWire, we strive to bring you the best service at the best price available. We have a wide selection of dumpster sizes in stock in Fenton, IA, with flexible & timley pickup and delivery. Give us a call today for all your dumpster rental and roll off needs.
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The Dutch Trade Register has almost 1,000 registered British Limiteds (Ltds). Is your Public Limited Company or Private Limited Company registered at the Chamber of Commerce? And is your company (almost) only active in the Netherlands? In that case you will need to adjust the registration and deposit a number of documents at the Dutch Chamber of Commerce.
British Ltd's are now registered at the Dutch Trade Register as a 'foreign EEA company' ('buitenlandse EER vennootschap'). EEA stands for European Economic Area and is a customs union. The United Kingdom will no longer be in this union after a no-deal Brexit, so changes are mandatory.
By Brexit, the legal form of these companies becomes a 'formal foreign company' ('formeel buitenlandse vennootschap').
You have to adjust this in the registration in the DutchTrade Register. In addition, you will need to deposit a number of documents at the Chamber of Commerce. After the UK leaves the EU you have 3 months to settle these matters. In case you do not change this in the Trade Register, you will risk personal liability. In the event of culpable bankruptcy, you may even be liable to a fine or even imprisonment.
It goes without saying that Ten Holter Noordam will gladly assist.


The Caster and the Rider.
Marvelous has released two short gameplay videos of Fate/Extella: The Umbral Star focused on Archimedes and Medusa.
If you missed it, previous videos focused on Iskandar, Jeanne d'Arc, Cu Chulainn, Li Shuwen, Elizabeth Bathory, Gawain, Lu Bu Fengxian, Gilgamesh, Karna, Mumei, Attila, Nero Claudius, and Tamamo no Mae.
Fate/Extella: The Umbral Star is due out for PlayStation 4 and PS Vita in Japan on November 10, and in North America and Europe this winter.


text:
The Baseball Report: No-Hit Bids On The Rise
Filed Under:MLB, Ryan Mayer, The Baseball Report
Ryan Mayer
Seattle Mariners pitcher James Paxton became the second Canadian-born pitcher to throw a no-hitter last week, when he dominated the Blue Jays in Toronto during the M's 5-0 win. Just a few days prior to that, four Dodgers pitchers combined to keep the San Diego Padres out of the hit column in a 4-0 victory. Those two no-hitters, combined with the one from Oakland A's lefty Sean Manaea back in April, mean we've seen three no-hitters in the first six weeks of the season. There were a combined two no-hitters over the course of the last two full seasons. The last time we saw three no-hitters by the second week of May was 1969 — Bill Stoneman (Montreal Expos), Jim Mahoney (Cincinnati Reds) and Don Wilson (Houston Astros).
Furthermore, Dave Sheinin of The Washington Post, took a deeper dive into the statistics and if you had the feeling that more pitchers are going deeper into games with no-hit bids than ever before, well, you're not exactly wrong. According to Sheinin, there have been 20 games this season in which a pitcher has taken a no-hitter into the seventh inning, which rates out as one of the highest percentages we've ever seen, as Sheinin explains.
"….one every 27.6 games, a rate not seen since 1968 — the fabled "Year of the Pitcher," in which Bob Gibson won the National League ERA title with a 1.12, Carl Yastrzemski won the American League batting title at .301, and MLB responded by lowering the mound in a bid to boost offense."
That's right, the last time we saw this kind of dominance on the pitching mound league-wide, the league responded by dropping the height of the mound in an attempt to generate more offense. As Sheinin further explains, the trend of the game's high-strikeout, high-power hitters tends to have a lot to do with the uptick in no-hit bids.
"It isn't difficult to see what is behind the trend: Hitters are striking out this year at a rate of 22.7 percent of all plate appearances, the highest in history and the 18th straight year with an increase. Meantime, the leaguewide batting average of .245 (down 10 points from 2017 and 26 points from 1999) is at a 46-year low. April 2018 was the first month in baseball history in which strikeouts exceeded hits, and May is on its way to being second."
On the topic of power hitters, the New York Yankees have quite the collection of high-strikeout, high-home-run-total guys. In the first six weeks, the Bombers also tied a little bit of history, due to their prodigious power-hitting trio of Gary Sanchez, Aaron Judge and Giancarlo Stanton with one surprise guest. For more on the Bombers and other stories from the past week in baseball, check out the video above.


In the Gospel of Life (Evangelium Vitae), John Paul II presents a powerful and prophetic teaching in defense of human life. Nowhere is this more evident than in Section 57 of the encyclical. Could the following be anything but an infallible and definitive teaching?
The footnote references the Vatican II document, Lumen Gentium, point 25. Point 25 talks about Papal Infallibility.
See also Section 58 of The Gospel of Life below which elaborates on this strong teaching in Section 57.
MOMENTOUS WORLDWIDE ADVENT VIGIL FOR UNBORN CHILDREN! THANK YOU BENEDICT XVI!
On the eve of the first Sunday of Advent – Saturday evening, November 27, 2010 – the Pope will lead a VIGIL FOR NASCENT HUMAN LIFE at St. Peter's in Rome, and he has asked the world's Bishops and priests to do the same in their own dioceses and parishes.
Americans please note the appropriate theme of thanksgiving which also relates to the national holiday weekend.
The call for this worldwide Vigil by our Pope is a breakthrough of momentous proportions for many reasons. But one not so obvious reason is that the Church tends to lean on her traditions, perhaps at times being slow to implement brand new ones. The Church has stood prophetically, time and again, for respect for human life from conception to natural death. But the Church has been slow to turn her coordinated worldwide liturgical prayer directly at the worldwide scourge of abortion. No longer!
Benedict's Pro – Life Prayer Vigil is to prayer, what John Paul II's encycylical Evangelium Vitae "The Gospel of Life" is to teaching. Our U.S. Chairman for the Catholic Bishops Committee on Pro – Life Activities, Cardinal DiNardo, says this Papal request is "unprecedented" – but that is an understatement.
By making this worldwide Vigil an Advent event, the Pope has now linked in our Catholic Christian consciousness the concept of the solidarity between Unborn Jesus and all unborn children. There is no turning back now!
Christians understand Jesus Christ as the answer and solution to our questions and problems. And He is that – the Way, the Truth and the Life for every human person.
But Pope Paul VI once made a telling observation: "Christ's coming into the world creates for us the problem and duty of knowing Him" (General Audience, 12/28/66). In fact, the Pope said that knowing Christ is our "first duty"…that "we must set out to seek Christ…to study whatever we can know about Him." He then directs our attention to the Gospel.
Thirty years later, John Paul II spoke about the Gospel of Life as consisting "in the proclamation of the very person of Jesus", and that "Through the words, the actions and the very person of Jesus, man is given the possibility of 'knowing' the complete truth concerning the value of human life" (Evangelium Vitae, #29).
Here we are, in the midst of a 'culture of death' and we can see why Christ's coming into the world is a sort of "problem"…. He is the fullness of Life and a champion of human rights and human life both – hence a champion of the human right to life! This message is not welcome in a 'culture of death'. Christ's message is part of who He is. So, in knowing Jesus Christ we come to know the fullness of human life and, as John Paul II says, we come to know "the complete truth concerning" human life.
For Christians, Christ is a problem if we love mammon more than God (Lk 16:13) or if we neglect prayer and the spiritual truths about life. It does seem to be a daily challenge to put Christ first in our lives. There is also a tendency for us all to superficially embrace our faith in Christ and falter in the demands of our faith.
Paul VI speaks of a spirit in the world promoting "systematic incertitude" and "systematic doubt and criticism". This is precisely the anti-faith pseudo tolerance that is widespread today, which 'tolerates' the killing of unborn children while musing on the uncertainties of life and meaning in life. In Christ we find a great Truth, a Truth with certainty about the value of human life, a Truth that is compelling and problem-solving by nature. Christ's Church has the duty to know Christ and His Truth, and is committed to hold on to this rock-solid Truth.
The strong manly apostle, St. Paul, had a tender side to him and revealed it, from time to time, to his "children in the faith". For example, in letters to the churches of Corinth and Philippi, he speaks about writing to them with tears (II Cor 2:4. Phil 3:18). But one of his better known quotes advises: "Rejoice with those who rejoice, weep with those who weep" (Rom 12:15).
Christ Himself is the model for this. St. John the Evangelist describes a very emotional scene following the death of Lazarus, when Mary the sister of Lazarus falls on the ground weeping before Jesus, and her friends and neighbors are around her weeping as well. John tells us that Jesus "was deeply moved in spirit and troubled". Then He asks where the body is laid, and when the people say "Lord, come and see" – Jesus breaks down and weeps. We are told that this is the shortest verse in the entire Bible: "Jesus wept" (Jn11:35).
Over the past few decades, billions of tears have been shed for unborn children. We can speculate that mothers have been the primary source of these rivers of tears simply because they are so close to unborn children, their lives more sensitized to tinier lives hidden within their bodies, their hearts listening for soft heartbeats signaling life close by.
Back in the early 1970's, as the Pro – Life movement was quickening, there was a powerful photograph of a tiny unborn child removed as a result of an ectopic pregnancy – my recollection is that the people referred to it as "the teardrop baby". The doctor who took the photo spoke about the remarkable effect this tiny unfortunate "unborn" child had on those present. But the image of an "unborn" baby naturally formed into a teardrop stopped people in their tracks.
Doctors tell us that unborn children feel pain (Watch Me Grow, by Professor Stuart Campbell, M.D., 2004). This is, of course, to state the obvious. 3D ultrasounds show unborn babies grimacing. Do they cry also?
Christ died for us, and no doubt He also shed tears during His Passion for us. In his Letter to the Galatians St. Paul speaks of "the Son of God, who loved me and gave himself for me" (Gal 2:20). In effect, St. Paul is saying that Christ 'died for me'. We can all say this with confidence. Likewise, each of us can say 'Christ shed a tear for me'. Which also brings us back to the unborn children – Christ shed a tear for each unborn child and loves each one personally.
Divine tears and human tears are a part of our lives now. The tear Christ shed for me is His tear of Hope for me. Because a great sign of the New Jerusalem is that God Himself will be with us and "He will wipe away every tear from (our) eyes" (Rev 21:3-4).
Station – Jesus meets the weeping women in Pfefferschlag He blesses those who are pregnant and the children in the square in front of the historic village church.
"They are a sharing in the mystery of the Cross, in which Jesus reveals the value of every person, and how life attains its fullness in the sincere gift of self. Over and above such outstanding moments, there is an everyday heroism, made up of gestures of sharing, big or small, which build up an authentic culture of life….
Part of this daily heroism is also the silent but effective and eloquent witness of all those 'brave mothers who devote themselves to their own family without reserve, who suffer in giving birth to their children and who are ready to make any effort, to face any sacrifice, in order to pass on to them the best of themselves'.
We thank you, heroic mothers, for your invincible love!
We thank you for your intrepid trust in God and in his love.


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Last edited by Tokinos
Wednesday, May 13, 2020 | History
8 edition of The Composition of the Rainbow and Women in Love found in the catalog.
by Charles L. Ross
Published March 1980 by Univ of Virginia Pr .
Novels, other prose & writers,
American - General,
Literary Criticism,
(David Herbert),,
1885-1930.,
Criticism, Textual,
Lawrence, D. H,
Lawrence, D. H.,
Psychological fiction, English,
Rainbow,
Women in love
By the end of The Rainbow, much of Ursula's struggles are unresolved. D.H. Lawrence wrote a follow-up novel, Women in Love, which delves more deeply into Ursula's life after the rainbow . Women in Love is D H Lawrence's most ambitious and experimental work, which attempts a radical critique of the modern world, and particularly modern British society, at the moment at which that world was coming into being, in the middle of the First World War. Early in , after finishing the autobiographical novel Sons and Lovers, his first major novel which .
Table of Contents Lady Chatterley's Lover The White Peacock The Prussian Officer and Other Stories The Lost Girl Kangaroo The Fox The Ladybird The Captain's Doll St. Mawr The Plumed Serpent The Rainbow The Woman Who Rode Away and other stories The Man Who Died The Virgin and the Gipsy Sons and Lovers Collected Short Stories Women in Love The. DH Lawrence's poetry saved from censor's pen The Rainbow and Women in Love. and the sequence is being fully published almost years after its wartime composition." Author: Dalya Alberge.
The Rainbow and Women In Love - Ebook written by D. H. Lawrence. Read this book using Google Play Books app on your PC, android, iOS devices. Download for offline reading, highlight, bookmark or take notes while you read The Rainbow and Women In Love. his two most innovative novels, The Rainbow () and Women in Love (), D.H. Lawrence traced the sickness of modern civilization—a civilization in his view only too eager to participate in the mass slaughter of the war—to the effects of industrialization upon the human psyche. Yet as he rejected the.
Definition study for photovoltaic residential prototype system
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Quality system supplement to ISO9001 relating to finite element analysis in the design and validation of engineering products
practical guide to testing object-oriented software
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Studies on cell-mediated immune response of cattle to parainfluenza-3 virus
A complete guide to the officers of His Majestys customs in the out-ports
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ANNUAL REVIEW OF ADULT LEARNING AND LITERACY. VOLUME 2. THE JOSSEY-BASS HIGHER AND ADULT EDUCATION SERIES... ED457341... U.S. DEPARTMENT OF
The Composition of the Rainbow and Women in Love by Charles L. Ross Download PDF EPUB FB2
Find many great new & used options and get the best deals for The Composition of The Rainbow and Women in Love: A History by Charles L. Ross (, Hardcover) at the best online prices at eBay. Free shipping for many products. Get this from a library. The composition of The rainbow and Women in love: a history.
[Charles L Ross; University of Virginia. Bibliographical Society.]. The story involves two sisters (the women who will fall in love), and two men (the recipients of this affection). Ursula and Gudrun Brangwen, the daughters of the protagonist of The Rainbow, begin the novel by having a discussion about marriage.
Ursula, the eldest daughter, is a schoolmistress (a teacher)/5(1K). 2 In The Rainbow, the evolution of the attention given to books across the three generations actually subtly conveys this expanding social for the other two novels, they are clearly set at a time when books have become available to the majority of people.
3 Lawrence, a passionate writer who wrote and published books throughout his life, and who could make Author: Elise Brault-Dreux. In its final form, Women in Love is less a continuation of The Rainbow than an altogether different novel.
To be sure, Ursula and Gudrun Brangwen persist in their quest for happiness. Women in Love is a difficult text because in it Lawrence insists that the conventional world is doomed, yet cannot fully trust the esoteric relationships that are the only countervailing forces on the side of life.
Hence the pathos of the novel, Birkin's vacillation between hatred of what is and tender care for the alternative world he wants to ed on: The women were different. On them too was the drowse of blood-intimacy, calves sucking and hens running together in droves, and young geese palpitating in the hand while the food was pushed down their throttle.
But the women looked out from the heated, blind intercourse of farm-life, to the spoken world beyond. Free kindle book and epub digitized and proofread by Project Gutenberg.
The Rainbow chronicles three generations of Brangwens living near Marsh Farm. Sexually stormy marriages set the stage for conflict and power struggles within the home.
Tradition, passion, children, and compromise define the Brangwen clan. Part 1: The context of Women in Love General Introduction Lawrence's early life and work The composition of Women in Love Women in Love and the First World War People, Places and Libel Threats Sexuality Class Part 2: Artistic Influences and Strategies Tradition and Experiment Thomas Hardy and the Russian Novel.
Ursula and Gundrun Brangwen's stories continue in Women in Love, as they meet and develop relationships with Gerald Crich and Rupert Birkin. HarperPerennial Classics brings great works of literature to life in digital format, upholding the highest standards in ebook production and celebrating reading in all its forms.
COVID Resources. Reliable information about the coronavirus (COVID) is available from the World Health Organization (current situation, international travel).Numerous and frequently-updated resource results are available from this 's WebJunction has pulled together information and resources to assist library staff as they consider how to handle.
Similarly, in The Rainbow and Women in Love, the sexuality of his characters throbs through the narrative like a feverish pulse. No one writes better than Lawrence about the complexity of desire.
The Rainbow was published in and was the prequel to Women in Love (). It is set in rural England in the early 20th century, and is the story of three generations of the Brangwen family.
It deals with themes like love, relationships, family, homosexuality, social mores, religious rebellion, just to name a few/5().
Lawrence IMHO went a bit unhinged in the s, but Women in Love, like The Rainbow, is a magnificent novel that captures degrees of feeling most novels appear not to even know exist.
(P.S. - good god, Amazon, we can't review novels any more without your silly "how would you describe the plot of this book?"/5(). "The Rainbow", published first inis the complete and exquisitely organized form of D.H. Lawrence's views about familial relationships. The novel relates the story of three generations of an English family — the Brangwens.
The Rainbow by D. Lawrence follows three generations of the Brangwen family, focusing on the sexual dynamics of, and relations between, the characters.
Lawrence's frank treatment of sexual desire and the power plays within relationships as a natural and even spiritual force of life caused The Rainbow to be prosecuted in an obscenity trial in Released on: Ap The Rainbow was banned upon publication inand all copies were subsequently seized and burnt.
Upon republication the novel achieved commercial success, shocking readers with its frank discussion of sexuality and women's physical desire. The Rainbow is the first of two Brangwen family novels, whose story is concluded in Women in Love/5(20).
This one-page guide includes a plot summary and brief analysis of Women In Love by D. Lawrence. Women In Love is a novel by D.H. Lawrence, first published in It is the sequel to his novel The Rainbow and continues the story of the Brangwen sisters, Ursula and Gudrun.
Both girls are in love, but in vastly different types of relationships. Women in Love by D. Lawrence, a free text and ebook for easy online reading, study, and reference. Women in Love, D.H Lawrence's sequel to The Rainbow (), continues to follow the lives of Ursula and Gudren Brangwen; two sisters living in the Midlands of England; a teacher and an artist respectively.
They meet two local men, chool inspector Rupert Birkin and coal. In Women in Love, the environment or setting often communicates characters' inner psychological attitudes.
Perhaps the most notable is the extravagant water-party hosted by the Crich family, which presents a microcosm of the social world and its hierarchical class structure.It was actually going to be one book, but he ended up having to split it because it was way long.
This is The Rainbow and Women in Love. The Rainbow is D.H. Lawrence's first .The Rainbow () was one of Lawrence's first novels to examine these themes, and is considered, along with its sequel Women in Love (), to be one of .
abcdfestivalgoa.com - The Composition of the Rainbow and Women in Love book © 2020


Refrigeration Cycle Tutorial: Step by Step, Detailed and Concise!
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I go over how the Basic Refrigeration Cycle works from where the refrigerant enters the vapor compressor as it goes completely through the system, what the saturated state is, what superheat, total superheat, and subcooling are, as well as other detailed comments as we go through the system.
These Videos are all part of our Training Series on HVACR Service, Installation, Preventative Maintenance, General Knowledge, and Tips. Please comment and ask for videos that you would like to see in the future! We come out with new videos every few days from my job sites, service calls, and the training shop! I hope you enjoy and find them very beneficial! See you next time at ACSERVICETECH Channel! Supervision is needed by a licensed HVAC Tech before doing this as Experience and Apprenticeship garners Wisdom and Safety.


text:
Home Chefs
Gastronomy is feminine: "We don't need quotas, we have to normalize the role of women to end the equality speech"
The third edition of 'Gastronomy is feminine' has focused on the role of women in the gastronomic story, understood in its broadest sense. Because gastronomy is part of the Spanish cultural identity and also a basic pillar of its economy, and thousands of women from all walks of life contribute to it, from chefs and sommeliers to communication, marketing, tourism, agriculture or industry workers.
Organized by Women in Equality and the Federation of Associations of Cooks and Bakers of Spain (Facyre), the meeting has been conceived as a sharing of ideas and knowledge, giving voice and visibility to women in a world that has traditionally always remained in the background. The situation is changing, but how is female empowerment reflected in gastronomy? What are the keys to achieving real equality?
Live to the PalateThese are the only 13 women who have won three Michelin stars in more than 80 years of the guide's history
The kitchen at home has always been linked to the figure of women, and it is still difficult to overcome that cliché today. If they have been the women who have carried the family's food on their shoulders and also from the people in the most difficult times, pouting where there was nothing, why in the history of gastronomy only male protagonists arrive?
Betting on equality policies is investing in the welfare state
It is irremediable to think about the sacrosanct Michelin Guide and the small number of female figures that appear leading restaurants. The picture is changing little by little, but there is still a chasm in terms of equality and many challenges to overcome. The numbers do not deceive, men continue to make headlines, awards, stars and media recognition, while the woman who triumphs cooking is still seen as an anecdote.
This approach has started this third edition of a forum that increasingly seeks to expand female voices to reflect on the whole discourse of gastronomy, understood as a global phenomenon. Carmen Fúnez, president of Women in Equality, highlighted the importance of the gastronomic sector in our country, as past, present and future, a future that will be unfeasible without investing in equality policies.
There are many women who promote hospitality, tourism, agriculture, fishing or the food industry; and only in an egalitarian environment can progress be made towards a competent future that guarantees the welfare state. And for that you have to normalize female presence and professionalization in all fields.
Live to the Palate These are the 17 most influential women in Spanish cuisine
Neither quotas nor positive discrimination: break with inherited tradition
Sara Fort (La Borda del Mentidero), Yolanda León (Cocinandos restaurant), Teresa Gutiérrez (Azafrán restaurant), María Salinas (María Salinas restaurant) and Cristina de la Calle (Etxeko restaurant)
In the current social context, it is common for women to be asked to succeed because they are still the exception. It's hard to explain why there are still so few Michelin stars with a female name, says Teresa Gutierrez, chef and owner of the Azafrán de Villarrobledo restaurant. The answer may be, in part, in the past, "before the woman stayed behind in everything", everyone expected them to take care of cooking, picking and cleaning.
Teresa Gutiérrez, Azafrán de Villarrobledo restaurant
Yolanda León, chef and co-owner of Cocinandos, Leon's restaurant with whom she has obtained a Michelin star with her husband Juanjo Pérez, differs a little. "It is not so much a problem of tradition but of education that we have been given as women and family obligations." Reconciliation is the key, the support of the couple and the family, does not presuppose that a woman is first a mother or a wife.
"We can be there because we are worth, we don't need fees"
When mentioning parity quotas or positive discrimination policies, chefs have it quite clear: they only contribute to further exclusion. Cristina de la Calle, sommelier of the Etxeko restaurant in Madrid, defends that the woman is well prepared to assume positions of responsibility - Leading a company does not differ much from running a home - but you must dare to take the plunge.
Maria Salinas, chef and owner of the homonymous restaurant in Palma de Mallorca, which she has with her daughter agrees with these ideas. Important advances have been made but "there is still much to be done." However, Salinas believes that the objective should be to break with the discourses of equality, not separate or discriminate. Only when the role of women is fully normalized, we will have achieved that equality.
Yolanda León and Juanjo Pérez, from the Cocinandos de León restaurant
To achieve that normalization, says de la Calle, it is also essential bet on professionalization that empowers women with all the necessary tools to assert themselves. "It is necessary to demand to the sector professionals trained in hospitality schools with homologated titles that contribute that necessary visibility".
And the generational renewal It will also be key. Only through an education that normalizes and assumes equality can we overcome the gender gap.
Direct to the Palate From Mesopotamia to the Michelin Guide: the history of women in the kitchen is the history of machismo
Female voices find new ways of communication
The world of professional cuisine is just one piece of all the gear that shapes the gastronomic sector in our country. The arrival of the internet and the emergence of social networks have opened new avenues for communication, a democratization that women have taken advantage of.
María Llanos and Mapi Hermida with the presenter Mónica Martínez
Already the role of gastronomic criticism does not fall solely on the five male names of always; digital media, blogs and social networks have given the opportunity to new voices, many feminine, to participate in the story and offer their point of view, sharing experiences and knowledge. This is seen by Mapi Hermida, director of communication and journalist, who believes that women "in networks we take more voice and initiative, we interact more."
Our partner María Llanos, Editorial Director of Direct to the Palate, with a long experience in communication of the sector, highlights that women have made their way into the culinary scene thus achieving alternative visibility, looking for their own ways of expression. In social networks such as Instagram, there seems to be a greater presence of women who also connect more with the visual aspect, taking more care of the aesthetic.
Digital media have democratized voices in gastronomy
In this way, the new media do seem to be giving women that visibility that costs more in professional haute cuisine. And the role of television? In addition to having turned the kitchen into a popular phenomenon, the chains try to take care of parity in a certain way, although that female presence "is not proportional, does not reflect everyday reality," says Llanos.
And precisely concludes that the media, traditional or digital, we have the responsibility to highlight the presence of women and attract the attention of the public. Communication professionals should assume fees to pay the same attention to men and women.
"We have to keep an eye out and tell all kinds of stories that deserve to be told, great stories and small intrahistories, starring famous chefs or anonymous women."
Photos | Unsplash Saffron Restaurant
Of your palate
https://foodologie.net za.foodologie.net © Chefs 2020


The Alexandria Police Department's Training Division operates the Alexandria Regional Police Academy that provides basic peace officer's training for its APD recruits and recruits form 9 local parish Sheriff's Offices and approximately 45 municipal departments. This program provides 17 weeks of basic recruit training to all cadets and prepares them to pass the Louisiana Police Officers Standardized Training Exam. Some examples of the training provided are firearms, control tactics, physical training, classroom training, and scenario-based training.
The Academy provides progressive and comprehensive training to develop policing skills, enhance leadership abilities, and promote a solid ethical foundation to all police cadets. In addition, throughout the entire Basic Program, the Academy's core values of professionalism, obligation, leadership, integrity, courage, and excellence are stressed and reinforced.
The cadets receive over 600 hours of basic recruit training, which exceeds the Louisiana State mandate by over 150 hours of training. Of the Louisiana State mandated material, cadets receive extra training in gangs, drugs, law, ethics, report writing, vehicle stops, control tactics, firearms, physical fitness, and law enforcement driving.
Also, cadets receive extra training that is not required by the State of Louisiana with classes such as terrorism awareness, diversity, technology awareness, and building entry tactics.


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Q: From ODE45 take Angular acceleration MATLAB I'm solving the eqaution motion and I need numerical integration, so I decided to use ode45 in Matlab. I  found the displacement and the velocity, now I need to find the Angular acceleration and make plot with time.
There's my code and function:
Code:
global r b m2 m3 m4 g I M

% Quantities
r=0.2;
b=0.1;
m2=1;
m3=0.2;
m4=2;
g=9.81;
tspan=0:0.01:2;

% Calculation
I=(m2*r^2)/3
M0=m2*g*b+g*r*(m3+m4)
M=1.2*M0

% Runge- Kutta
[t,x]=ode45(@funkce,tspan,[0 0]);

% Plotting
figure(1);
plot(t,x(:,2));
grid;

figure(2);
plot(t,x(:,1));
grid;

Function:
function v=funkce(t,x);

global r b m2 m3 m4 g I M

% Method
v(1,1)= (x(1)^2*(m4*r^2*cos(x(2))*sin(x(2)))+M-cos(x(2))*m2*g*b+(m3+m4)*g*r)/(I+m3*r^2+m4*r^2*cos(x(2))^2);
v(2,1)= x(1);

A: Maybe, I'm missing something but if you have the displacement and velocity, the only thing you need to do to get the acceleration is to differentiate the velocity:
% Assuming x(:,1) is the velocity, haven't checked your equations
accel = zeros(size(x(:,1)));
accel(2:end) = diff(x(:,1))./diff(t);

However, when I tried to run your code on Octave, ode45 wasn't able to solve the equations. The plots looked like this:

Are you able to obtain meaningful results for the displacement and velocity in MATLAB? If not, I suggest you check your equations and make sure you get sensible results before trying to derive the acceleration.

redpajama_set_name: RedPajamaStackExchange


1. How does Gulliver get to Laputa?
2. How does Laputa differ from a normal country?
3. How do the people differ from those in most countries?
4. What unusual kind of servants do the better-off Laputans have?
5. What is unusual about Laputan food and clothing?
6. What does the King of Laputa ask Gulliver about England?
1. Gulliver gets to Laputa after being cast adrift on a small boat by pirates who have captured his ship.
2. Laputa is a flying or floating island, moving above the ground.
3. The Laputans are almost totally absorbed in abstract spec¬ula¬tion, to the neglect of practical activities.
4. The better-off Laputans have servants called "flappers." Their servants gently hit them with balloon-like objects filled with dried peas or pebbles so they will not be totally distracted in thought from the outside world.
5. Laputan food is shaped like geometrical figures or musical instruments and their clothing is similarly decorated. Their clothing is also decorated with astronomical figures. Clothing is made and fitted using navigational instruments and mathematical calculations, and it is ill-fitting.
6. The King of Laputa asks Gulliver about the state of mathe¬matics in England; he is interested in nothing else about England.
7. A magnetic rock in a cave in the center of the island of Laputa makes it fly.
8. The Laputans put down rebellions by flying over the rebellious area, blocking out sunlight, and if necessary throwing down rocks.
9. Laputan astronomers have discovered two additional satellites of Mars.
10. Rebels against Laputa were able to get favorable terms by putting magnetic towers at the four corners of their city, defeating Laputan measures against them.
1. How does Gulliver leave the Floating Island?
10. What does Gulliver propose to the Academy of Lagado?
1. Gulliver leaves the Floating Island by getting a court official, related to the King, to intervene.
2. The Academy of Lagado originated when some people from the continent of Balnibarbi spent some months on the Floating Island, learning a little mathematics but filling themselves with "volatile spirits," meaning impractical, theoretical orientation (not liquor).
3. The consequence of the Academy is poverty, caused by the neglect of practical work in favor of visionary, impracticable, schemes.
4. The Academy of Lagado comes up with a variety of visionary, impracticable schemes that have not yet been perfected (and presumably never will be).
5. The first scholar Gulliver sees at the Academy of Lagado has been working for eight years on a project for extracting sunbeams from cucumbers.
6. The architect Gulliver first sees at the Academy is trying to build houses from the top down.
7. The first physician Gulliver sees at the Academy is trying to cure patients with a bellows.
8. The first activity Gulliver sees in the more theoretically oriented part of the Academy is an attempt to create new writings by putting all the words of the language on pieces of wood, linked by wires, on an enormous frame and rearranging them mechanically.
9. The politicians are trying to cure professors with medicines and violent attacks, or through brain transplants.
10. Gulliver proposes to the Academy of Lagado a scheme to accuse people of plots against the state by misinterpreting their letters as secret codes.


We really enjoy it and find great value from exhibiting. This is my 4th year, but I believe at least the 5th for the business. Particularly resonates with me as the new venue in Loughborough brings back memories, as it is where I studied at University.
We have chosen to exhibit as we have a fee free dedicated business rail booking tool, that we would like to promote to gain direct relationships with businesses in our region.


Merry Christmas and/or Boxing Day To ALL!!!
I see its not snowing anywhere; at least not the places this blog covers! And poor Scott and Leigh are suffering through 22C and sunny. Hope the spirit of Christmas is with you all. Viv, Tim and Brady join me in wishing y'all a wonderful New Year, as well.
A wonderful Christmas to all!!
Shelley is now back home in her own bed. She's definately stiff and sore and moves pretty slowly, but she seems to feel okay.
As it turns out, Shelley felt pretty crappy Sunday and Monday anyway, so it really wasn't a bad thing.
It's good to have her home.
Elvis has left the Pelvis!
The cyst, formerly known as Elvis, has finally left Shelley's pelvis.
Seemingly, everything went just fine, they took out the cyst (no word on a couple other potential proto-cysts) along with all her reproductive plumbing — with the exception of ONE overy, left for hormone producing purposes.
Everything has been declared benign.
Shelley was already telling me what I needed to do when I got home, so we KNOW she's not feeling too badly.
We ALL know what a Code Blue is! And where is Shelley? "Urology O.R. 1" sounds like a fairly likely place! So, after about 10 minutes of pacing and fretting, I phoned Shelley's Mom (not quite sure where the logic of that was), and, of COURSE, her response was, "Ask the nurse, you loser BE ASSERTIVE!" Well, it WASN'T Shelley (obviously), and I now feel stupid, but relieved.
All that's left for us now is recovery. I can DEAL with that!
A quick entry because it's late and I'm tired. Shelley has surgery booked for tomorrow afternoon. I'll fill you all in with the good word tomorrow night.
You are currently browsing the The Perpetual Weblog weblog archives for the year 2005.


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text:
Governor's Veto Leaves California Safe Injection Site Plans in Limbo
Author Mark Mravic Published on August 24, 2022 4 min read
Plus: A follow-up to Dopesick, and more treatment industry news
By Mark Mravic
New & Next: Policy
Newsom's Veto Leaves California Safe Injection Sites in Limbo
California Gov. Gavin Newsom's veto this week of a bill passed by the state's legislature that would have permitted safe injection sites (SIS) in Oakland, San Francisco and Los Angeles has met with harsh criticism from harm reduction advocates and sparked plans to move forward without the governor's approval.
"Worsening drug consumption challenges in these areas is not a risk we can take."
—Gov. Gavin Newsom
In vetoing Senate Bill 57, Newsom said he was concerned about the operation of SIS's "without strong, engaged local leadership and well-documented, vetted, and thoughtful operational and sustainability plans." He noted the potential for "unintended consequences" in Los Angeles, San Francisco and Oakland, saying, "Worsening drug consumption challenges in these areas is not a risk we can take." Some observers speculate that the Democratic governor's softening of support for harm reduction could be meant to head off conservative criticism in advance of a possible presidential run.
Despite the veto, San Francisco officials say they will move forward in allowing a local nonprofit to open a site, along the model set by New York City, which established two SIS's last November, though which nonprofit and how the site is funded are yet to be determined. Safe injection sites occupy a gray area legally—negotiations over a federal lawsuit that blocked a site in Philadelphia are ongoing, and the Biden administration is currently evaluating its policy on such programs. Decisions on those fronts should determine whether or not the federal government considers SIS's as violating the "crackhouse statute" of the Controlled Substances Act, which prohibits places that operate with the sole purpose of using or selling drugs.
New & Next: Media
Now out: Raising Lazarus, the Follow-up to Dopesick
Beth Macy's 2018 bestseller Dopesick traced the rise of the American opioid epidemic by interweaving powerful personal stories of its impact with investigations into the corporate, medical and legal forces underpinning the crisis. The book was made into a gripping Hulu miniseries that brought the overdose epidemic into American living rooms. Macy's follow-up, Raising Lazarus: Hope, Justice and the Future of America's Overdose Crisis, published last week by Little, Brown & Co., moves the story forward, with profiles of treatment innovators and harm reductionists working on the frontlines to stem the tide and find solutions, as well as bereaved families pushing to hold to account the Sackler family and others in the pharmaceutical industry who profited from the epidemic. In its review, Esquire called Raising Lazarus "enlightening and exhaustive … at once a damning exposé about greed and a moving paean to the power of community activism."
New & Next: Grants
$2.5 Million for Harm Reduction Education in Louisiana
Alexis Horace
The Substance Abuse and Mental Health Services Administration (SAMSHA) has awarded a four-year, $2.5 million grant to Alexis Horace, PharmD, associate professor of clinical practice at the University of Louisiana-Monroe (ULM), to provide harm reduction education to first responders and community members. The grant will fund a training program called ULM HERO that will instruct first responders in Orleans and Ouachita parishes and surrounding rural areas in the use of naloxone and in how to connect people who use opioids with treatment and recovery services. Horace's team, which she is in the process of building, will also host 50 community events to provide risk reduction education in underserved communities, with a goal of training 4,000 people over the next four years.
"The term 'first responders' is defined broadly," Horace said. "We have our traditional first responders, like police officers, EMS, firefighters and FEMA. We will target those organizations with our harm reduction education course. The second group of first responders are those that live in our communities. It is the person who is the first to respond to a scene. It may not necessarily be someone who is a medical [professional], but a friend or a family member. … My team and I are ready to help our first responders in our community and make a big change in Louisiana. It's going to be used, and it's going to save lives."
Horace, who teaches at the ULM satellite campus in New Orleans, says she was inspired by her students who work with a local syringe services program. The grant is the largest given to the university in more than a decade.
New & Next: Conferences
National Harm Reduction Conference in Puerto Rico
Registration is open for the 13th National Harm Reduction Conference, which will take place at the Caribe Hilton in San Juan, Puerto Rico, Oct. 13-16. The four-day event brings together creative minds in the harm reduction movement from the U.S. and abroad to exchange ideas and innovative practices. In addition to panels, workshops and roundtables, the conference will include informational talks, meet-the-author sessions, networking opportunities, a film festival and more. For information and to register, go here.
Top photo: Maarten Van Den Heuvel
California.Gavin NewsomRaising Lazarussafe injection sites
Christina Simos on the Need for Diversity in Treatment Leadership
Weed, Hallucinogen Use Peaks Among Young Adults
Category From the Journals
Time to Recognize, and Treat, Pre-addiction
Published on July 18, 2022 7 min read
An Addiction Treatment Bill of Rights
California's Controversial Mental Health Courts for the Homeless
Massachusetts to Provide Student Loan Relief for Addiction Care Workers


Anyone who knows me knows I do not let dust grow under my feet – I like to get things done.
So yes, I was first call to my surgeon's office this morning, but hell, she gave me the date yesterday she could cut the lump out and I want that set in stone. I also want them to fight for me to get my radiation treatments scheduled closer to me because I am not a lady who lunches, I have to work and am self-supporting. Six weeks of chemo, five days a week at a site not close to my office might prove to be financial hardship.
Ok, I am trying to be patient and say to myself they just walked in the door, etc., but on the other hand, while this is normal to them, there is nothing normal about this to me and I am the breast cancer patient and a new one at that. I also know that I do have to be my own best advocate and continue being proactive. I need that for me to survive.
Good lord people, I have a plan…work with me here.
This entry was posted in Uncategorized and tagged breast cancer, life, Living Beyond Breast Cancer, patience, women. Bookmark the permalink.
Who says you have to be patient? Patience is an act of manners and consideration for OTHERS. I'm sure you don't want to abandon civility, but this is about YOU. As you said YOU're the one with the cancer. Let THEM be patient with YOU!
Glad to hear (though not nearly as glad as you, I'm sure) to hear that your diagnosis, course of treatment and prognosis are not as bad as they could have been.
It's probably hard to keep in the forefront of your mind, but, yes, it could be worse, and yes, there are others out there with greater troubles.
Happy Birthday. Let's keep them coming.
i just had a giggly thought in wonka, the spoiled brat says "I want an oompaloompa and I want it now!" and I hear you saying "I want a lumpaouta and I want it now!" Can't blame you one bit.


The Miz Mooz Aster is a strappy flat sandal made of buttery-soft leather with a signature cushioned footbed, perfect for adventures in hot places everywhere. All leather upper, rubber outsole, side buckle entry, designed in NYC. Order in whole US sizes.


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ViewsPk
View latest news updates from Pakistan and around the world. Daily Pakistan is a newspaper in Pakistan, published both in English.
Home / Science / Freedom of expression: Internet watchdog in Pakistan, 'this has been a year of aggressive sanctions'
Freedom of expression: Internet watchdog in Pakistan, 'this has been a year of aggressive sanctions'
viewspk November 05, 2020 Science
One year ago, in October last year, the Pakistani government enlisted the help of Sandwin, a controversial Canadian company, to monitor and review information transmitted across the country via the Internet.
Under the کروڑ 18 million agreement, the Internet monitoring system will use Deep Packet Inspection (DPI), which means information ranging from Internet monitoring to a user's personal call data.
Last year, the news was published on a website called Koda Story in New York, which raised concerns and raised questions about the extent to which Internet users are being monitored in Pakistan and through it. What will happen to those who criticize the government?
Fareeha Aziz, co-founder of Bolo Bhi, a digital rights organization, says the surveillance system is like listening to a conversation between two people, or sent by someone. Open the letter and read.
The above incident is part of all the restrictions that have been imposed on those who speak or work online this year and which are also part of the report released today by the organization working on digital rights.
This year, FIRs were also filed against commentators, social networking apps were alerted or blocked, and laws were used that social workers had previously warned that They are against the basic rights of the people.
Now, on International Internet Day, a report published by the Freedom Network, an organization working on freedom of expression, is also presenting a very bleak picture.
The annual report on digital rights is based on the rules and regulations for the prevention and strict monitoring of information on the Internet, hate speech on social networking sites and freedom of expression. And the progress made in this regard has been included in the report.
According to the report, aggressive measures were taken by the federal government, which not only restricted the media but also banned the expression of speakers on social networking sites and other platforms. While video bloggers and tickers are subject to these laws, social workers, politicians, journalists and lawyers could not escape them.
In 2020, Pakistan was ranked 38th out of 100 in the Freedom of the World's Freedom of Expression List. The report described Pakistan as "partially independent".
If we look at some of the events that will take place in 2020 now, it would not be out of place to say that there is only an increase in online hardships.
In July of this year, the first tick-tack video app was issued in a row, while another app, Bego Live, was shut down. This month, Tik Tak was shut down again for failing to heed the warning.
The Pakistan Telecommunications Authority (PTA) banned the ban on the basis of "immoral and indecent content". But ten days later, the app was conditionally reopened.
It should be noted that according to PTA's own statistics, as of July this year, there are about 20 million tick talk users in Pakistan.
Iqbal Khattak, executive director of the Freedom Network, said in the report that "it is unfortunate that this has significantly affected journalism limited to the Internet, while freedom of expression has largely been transformed into language."
Tik Tak, Pakistan,
, Image source GETTY IMAGES
Journalist and Pika Law
According to the Freedom Network, the Prevention of Electronic Crimes Act (PECA) was used indiscriminately against journalists and columnists. So that journalists and columnists active on social networking sites can be bound by a particular point of view.
"We've seen a lot of activity in the last two months," Fareeha said. On the one hand, Section 37 of the PKK was used to stop journalists. Then there are the concerns we raised earlier this year about the same law. Another draft of the same law has been prepared under different names. And whatever the circumstances, it looks like it will be approved. "
The federal cabinet issued new rules a month ago to curb online content. A PKK-style law, Citizens Protection Against Online Harm Rules 2020, was blocked as a result of timely social and human rights activists raising their voices.
"You have removed one journalist after another from the prime time show," says Fareeha. So now they have social media or YouTube as the only way to express themselves. But it is also being restricted and tightened so that nothing special can happen.
So is September... According to a report in Khar, the names of 49 journalists, including columnist Ammar Masood and journalist Aizaz Syed, were included in a list allegedly prepared by the Federal Investigation Agency (FIA). While the FIA denied the news, there was a lot of noise from journalists and other activists.
Speaking to the BBC, columnist Ammar Masood said: "We have been told very clearly not to talk. During a press briefing, red circles were drawn around the photos of several journalists as they were harassing institutions through their freedom of expression. As a result, well-known journalists are now confined to homes and online, while those who follow their narratives are thriving.
On the one hand, regarding the FIRs that are being registered, Fareeha Uzair says that Pakistan Penalties are also being included in them so that defamation provisions can also be included during the trial.
Freedom Network reports that Pakistani authorities have severely curtailed internet freedom this year, while issuing warnings to journalists and social activists over posts posted on Twitter or Facebook, as well as politically motivated.
Freedom of expression: Internet watchdog in Pakistan, 'this has been a year of aggressive sanctions' Reviewed by viewspk on November 05, 2020 Rating: 5
'Anti-Muslim Content Controversy': Who are the Inkhis of India Facebook?
Mobilink, Jazz: Telecom company accused of non-payment of Rs 25 billion in taxes, FBR seals company office
Debate on social media: Was Interior Minister Ijaz Shah's speech a warning or a threat?
Pakistan (13) Science (12)


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National Post: Citizen Group Aims to Halt Rob Ford's Request for a Study into Porter's Expansion Bid
posted by NationBuilder Support on May 12, 2013
National Post Covers NoJetsTO Argumentation Against Costly and Unnecessary City Study of Island Airport Expansion Plans May 13, 2013 TORONTO - Days ahead of a city council vote on studying Porter Airline's bid to fly jets in and out of the island airport, a new citizen group has emerged hoping to halt expansion plans before take off. But ask one of the leading critics of the Porter proposal if there are enough votes to scrap Mayor Rob Ford's request for a report, and the response makes it sound far from a sure thing. "Maybe," says Councillor Adam Vaughan. "We will have to wait and see." Porter CEO Robert Deluce has asked the city, the federal government and the Toronto Port Authority to amend an agreement that bans jets and to allow a 168 metre extension of the main runway on either end. Porter is seeking permission to operate the new Bombardier CS100 planes, which it calls "whisper jets," and the company wants an answer from the city by July. The request has won early support from Mayor Rob Ford but several councillors have voiced opposition. On Friday, the nascent No Jets T.O. launched a website and had an inaugural press conference in Nathan Phillips Square. "This is not a fight against Porter. This is not a fight against the island airport," said Anshul Kapoor a 33-year-old marketing specialist and waterfront resident. "This is a fight against Robert Deluce's ambition to bring jets to the island airport and change our city forever." He was joined by Beverly Dywan, who lives around St. Clair Avenue and who has a child at the Waterfront School. They said they represent a coalition of citizens and local groups, and have the support of the York Quay Neighbourhood Association, Bathurst Quay Neighbourhood Association, Toronto Island Community Association and CommunityAIR. "People are concerned," said Ms. Dywan, a consultant for museums and other cultural institutions who along with Mr. Kapoor has flown Porter. They are asking councillors to block the study, arguing it would be a waste of money and impossible to complete by July, given that a traffic study took a year. The mayor's executive has demanded that Porter foot the bill for a comprehensive look at various issues, which city staff estimated would cost at least $200,000. A spokesman for Porter said Friday the company is open to paying "reasonable costs" of a review that is completed in a "timely manner." Brad Cicero, manager of communications and public affairs, declined to speculate on Porter's chances of passing the first hurdle next week. "Anybody who is actually looking to get all the information and understand the proposal fully should be in favour of simply approving a staff report," he said. Source: National Post article


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Vaccine information (Moderators: larsonstdoc, donnay, decemberfellow) »
CDC - National Hepatitis Testing Day - Proposes Boomers Be Tested for Hep-C
Author Topic: CDC - National Hepatitis Testing Day - Proposes Boomers Be Tested for Hep-C (Read 3350 times)
http://www.cdc.gov/nchhstp/newsroom/HepTestingRecsPressRelease2012.html
For immediate release: May 18, 2012
CDC Announces First Ever National Hepatitis Testing Day and Proposes that All Baby Boomers Be Tested Once for Hepatitis C
On the eve of the first ever National Hepatitis Testing Day (May 19), the Centers for Disease Control and Prevention is issuing draft guidelines proposing that all U.S. baby boomers get a one-time test for the hepatitis C virus.
One in 30 baby boomers – the generation born from 1945 through 1965 – has been infected with hepatitis C, and most don't know it. Hepatitis C causes serious liver diseases including liver cancer, which is the fastest-rising cause of cancer-related deaths, and the leading cause of liver transplants in the United States.
CDC believes this approach will address the largely preventable consequences of this disease, especially in light of newly available therapies that can cure up to 75 percent of infections.
"With increasingly effective treatments now available, we can prevent tens of thousands of deaths from hepatitis C," said CDC Director Thomas R. Frieden, M.D., M.P.H.
More than 2 million U.S. baby boomers are infected with hepatitis C, accounting for more than 75 percent of all American adults living with the virus. Baby boomers are five times more likely to be infected than other adults. Yet most infected baby boomers do not know they have the virus because hepatitis C can damage the liver for many years with few noticeable symptoms. More than 15,000 Americans, most of them baby boomers, die each year from hepatitis C-related illness, such as cirrhosis and liver cancer, and deaths have been increasing steadily for over a decade and are projected to grow significantly in coming years.
"Identifying these hidden infections early will allow more baby boomers to receive care and treatment, before they develop life-threatening liver disease," said Kevin Fenton, M.D., director of CDC's National Center for HIV/AIDS, Viral Hepatitis, STD and Tuberculosis Prevention.
Current CDC guidelines call for testing only individuals with certain known risk factors for hepatitis C infection. But studies find that many baby boomers do not perceive themselves to be at risk and are not being tested.
CDC estimates one-time hepatitis C testing of baby boomers could identify more than 800,000 additional people with hepatitis C, prevent the costly consequences of liver cancer and other chronic liver diseases and save more than 120,000 lives.
CDC's draft recommendations will be available for a public comment period from May 22 – June 8, 2012.
http://www.bloomberg.com/news/2012-05-18/test-all-baby-boomers-for-hepatitis-c-cdc-urges.html
Testing may help prevent cirrhosis and liver cancer, both of which result from infection, public health officials said.
Baby boomers were infected in their teens and 20s, either through blood transfusions before HIV concerns
prompted widespread screening in 1992,
or with experimental injection drug use.
Hepatitis C is often asymptomatic while it damages the liver, the CDC said in a statement.
Standard Treatment
The standard treatment for hepatitis C for the past decade has been a combination of the antiviral drug ribavirin with interferon, an immune-boosting protein. Patients receive weekly shots of Interferon for as long as a year, which can cause side effects such as fatigue and flu-like symptoms.
Other important announcements tied to the first National Hepatitis Testing Day include:
•The release of a $6.5 million funding opportunity announcement to expand testing of hepatitis B and hepatitis C, increase earlier diagnosis of individuals with infections, and enhance linkage to care, treatment and preventive services for people living with these infections.
Funded efforts will focus on groups that are disproportionately affected by the disease, including Asian-American Pacific Islander communities who have the highest rates of hepatitis B, and injection drug users and individuals born from 1945 – 1965 who are most affected by hepatitis C. These efforts align with the U.S. Department of Health and Human Services' Action Plan for the Prevention, Care and Treatment of Viral Hepatitis, which was released in May 2011.
•Adding additional tools and resources to the CDC Know More Hepatitis website, including a new online Hepatitis Risk Assessment tool. This tool is designed to help people determine their risk for viral hepatitis.
•Collaborating with HHS to produce PSAs featuring HHS' assistant secretary for health, Howard Koh, M.D., and Surgeon General Regina Benjamin, M.D., with specific outreach to high-risk communities on the importance of testing.
For additional information about hepatitis, visit www.cdc.gov/hepatitis.
related see: Climate change could boost U.S. dengue fever - HCV BioWeapon
Related: BioWeapon Hepatitis-C 5x times more deadly then Hep-B - no vaccine
Re: CDC - National Hepatitis Testing Day - Proposes Boomers Be Tested for Hep-C
http://www.hcvets.com/
HCVets.com Educational Website & Support Forums are provided by past and presents members of the United States Military with Hepatitis C (HCV) to assist fellow Retirees/Veterans / Active Military and Dependents with awareness to the Hep C virus exposure methods during military service.
The VA Testimony before the Subcommittee on Benefits Committee on Veterans' Affairs, U.S. House of Representatives, April 13, 2000, Gary A. Roselle, M. D., Program Director for Infectious Diseases, Veterans Health Administration, Department of Veterans Affairs, state,
"One in 10 US Veterans are infected with HCV", a rate 5 times greater than the 1.8% infection rate of the general population."
One in 5 of these Veterans are from the Vietnam era.
A study conducted in 1999, by the Veterans Health Administration (VHA), and involving 26,000 veterans shows that up to 10% of all veterans in the VHA system tested positive for hepatitis C.
Of the total number of persons who were hepatitis C antibody positive, and reported an era of service, 62.7% were noted to be from the Vietnam. The second most frequent group is listed as post-Vietnam at 18.2%, followed by 4.8% Korean conflict, 4.3% post-Korean conflict, 4.2% from WWII, and 2.7% Persian Gulf era veterans.
http://www.cdc.gov/mmwr/preview/mmwrhtml/00055154.htm
Recommendations for Prevention and Control of Hepatitis C Virus (HCV) Infection and HCV-Related Chronic Disease
October 16, 1998 / 47(RR19);1-39
Hepatitis C virus (HCV) infection is the most common chronic bloodborne infection in the United States.
CDC staff estimate that during the 1980s, an average of 230,000 new infections occurred each year (CDC, unpublished data). Although since 1989 the annual number of new infections has declined by greater than 80% to 36,000 by 1996 (1,2), data from
the Third National Health and Nutrition Examination Survey (NHANES III), conducted during 1988-1994, have indicated that an estimated 3.9 million (1.8%) Americans have been infected with HCV (3).
Most of these persons are chronically infected and might not be aware of their infection because they are not clinically ill. Infected persons serve as a source of transmission to others and are at risk for chronic liver disease or other HCV-related chronic diseases during the first two or more decades following initial infection.
Chronic liver disease is the tenth leading cause of death among adults in the United States, and accounts for approximately 25,000 deaths annually, or approximately 1% of all deaths (4). Population-based studies indicate that 40% of chronic liver disease is HCV-related, resulting in an estimated 8,000-10,000 deaths each year (CDC, unpublished data). Current estimates of medical and work-loss costs of HCV-related acute and chronic liver disease are greater than $600 million annually (CDC, unpublished data), and HCV-associated end-stage liver disease is the most frequent indication for liver transplantation among adults. Because
most HCV-infected persons are aged 30-49 years
(3), the number of deaths attributable to HCV-related chronic liver disease could increase substantially during the next 10-20 years as this group of infected persons reaches ages at which complications from chronic liver disease typically occur.
HCV is transmitted primarily through large or repeated direct percutaneous exposures to blood. In the United States, the relative importance of the two most common exposures associated with transmission of HCV, blood transfusion and injecting-drug use, has changed over time (Figure_1) (2,5). Blood transfusion, which accounted for a substantial proportion of HCV infections acquired greater than 10 years ago, rarely accounts for recently acquired infections.
Since 1994, risk for transfusion-transmitted HCV infection has been so low that CDC's sentinel counties viral hepatitis surveillance system* has been unable to detect any transfusion-associated cases of acute hepatitis C, although the risk is not zero. In contrast, injecting-drug use consistently has accounted for a substantial proportion of HCV infections and currently accounts for 60% of HCV transmission in the United States. A high proportion of infections continues to be associated with injecting-drug use, but for reasons that are unclear, the dramatic decline in incidence of acute hepatitis C since 1989 correlates with a decrease in cases among injecting-drug users.
Reducing the burden of HCV infection and HCV-related disease in the United States requires implementation of primary prevention activities to reduce the risk for contracting HCV infection and secondary prevention activities to reduce the risk for liver and other chronic diseases in HCV-infected persons. The recommendations contained in this report were developed by reviewing currently available data and are based on the opinions of experts.
These recommendations provide broad guidelines for
a) the prevention of transmission of HCV;
b) the identification, counseling, and testing of persons at risk for HCV infection; and
c) the appropriate medical evaluation and management of HCV-infected persons.
We need to look at the HCV "test", One problem I see is that the test shows positives for exposure to HCV.
If sometime in the past you were exposed to an infected person, you may have anti-bodies for HCV but never had the disease... hmmm
See the related threads that show treatment with interferon causes some people to be suicidal.
http://labtestsonline.org/understanding/analytes/hepatitis-c/tab/test
Also known as: Hepatitis C antibody; anti-HCV; HCV recombinant immunoblot assay; HCV RIBA; HCV-RNA; Hepatitis C viral load
Formal name: Viral Hepatitis C
Related tests: Hepatitis A; Hepatitis B; Acute Viral Hepatitis Panel; Liver Panel; ALT; AST; GGT, Bilirubin
Anti-HCV test detects the presence of antibodies to the virus, indicating exposure to HCV.
This test cannot distinguish between someone with an active or a previous HCV infection. Usually, the test is reported as "positive" or "negative." There is some evidence that if the test is "weakly positive," it may be a false positive.
The Centers for Disease Control and Prevention (CDC) suggests that weakly positive tests be confirmed with the HCV RIBA test before being reported.
HCV recombinant immunoblot assay (RIBA) test is an additional test ordered to confirm the presence of HCV antibodies. In most cases, it can tell if the positive anti-HCV test was due to exposure to HCV (positive RIBA) or represents a false signal (negative RIBA).
In a few cases, the results cannot answer this question (indeterminate RIBA). Like the anti-HCV test, the RIBA test cannot distinguish between a current or past infection.
HCV Viral Load (HCV RNA test, Quantitative) detects and measures the number of viral RNA particles in the blood. Viral load tests are often used before and during treatment to help determine response to treatment by comparing the amount of virus before and during treatment (usually at several time points in the first three months of treatment). Successful treatment causes a decrease of 99% or more (2 logs) in viral load soon after starting treatment (as early as 4-12 weeks) and usually leads to viral load being not detected even after treatment is completed. Some newer viral load tests can detect very low amounts of viral RNA.
Viral genotyping is used to determine the kind, or genotype, of the HCV virus present. There are 6 major types of HCV; the most common (genotype 1) is less likely to respond to treatment than genotypes 2 or 3 and usually requires longer therapy (48 weeks versus 24 weeks for genotype 2 or 3). Genotyping is often ordered before treatment is started to give an idea of the likelihood of success and how long treatment may be needed.
bump for article on HIV screening
I'm not going to get tested. My BP--110/68, pulse 52, 20-20 vision in both eyes. I eat mostly vegan.
My philosophy---if you don't have symptoms, don't go to the doctor. THEY WANT MORE BUSINESS.
http://www.hcvets.com/data/occupational/munji/toc.htm
2015- According to Veterans Affairs interview with NewsWeek, 50,000 veterans that have hepatitis C remain unidentified in the Health Administration. Jetgun devices are not listed as a risk factor for screening. Read more
Jetgun (Airgun) Injections
(AKA MUNJI or PCNFI)
http://www.va.gov/vetapp05/files5/0531165.txt
On appeal from the Department of Veterans Affairs (VA) Regional Office (RO) in Reno, Nevada
Entitlement to service connection for Hepatitis C.
The veteran had active service from July 1978 to May 1980.
This matter comes before the Board of Veterans' Appeals
(Board) from a November 2004 RO rating decision which denied
service connection for Hepatitis C. Pursuant to an October
2005 motion and the Board's granting thereof, this case has
been advanced on the Board's docket under 38 U.S.C.A. § 7107
(West 2002) and 38 C.F.R. § 20.900(c) (2005).
FINDING OF FACT
Hepatitis C is a result of receiving immunizations in service
by means of a multi-use jet gun injector.
Hepatitis C was incurred in service. 38 U.S.C.A. § 1131
(West 2002); 38 C.F.R. § 3.102, 3.303 (2005).
B. Service Connection for Peripheral Neuropathy
Service connection may be granted for a disability resulting
from injury or disease incurred in or aggravated by active
service. 38 U.S.C.A. § 1131; 38 C.F.R. § 3.303.
In this case, the veteran contends that he received
vaccinations in July 1978, upon entry into active duty, and
that these injections were given by a type of air injector
and were not sanitized between injections on recruits.
The pertinent evidence of record will be briefly summarized.
Service medical records show that the veteran received
several vaccinations and immunizations upon his entry into
service in July 1978. Service medical records show no high
risk activities other than on the veteran's entrance (and
separation) examinations it was noted that he had two tattoos
on his arms.
Post-service private treatment records show that Hepatitis C
was diagnosed in 2002, and that the veteran had elevated
liver function tests in the years prior to that.


You probably noticed but Winter's back! If the cold offshore didn't remind you then getting rattled by your first bomb set of the session would have.
I wandered down the beach with no leash thinking it'd be a cruisey two foot then boom, a solid 4 footer rolls in! The South swell is up, it's clean and, surprisingly, it's holding up pretty well straight out front. Surfing is on!
Now winter's back in town, it might be time for another look at that NCHE Full Suit you had your eye on. Click through, sign up and they'll hook you straight up with 15 percent off.