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Unicode provides about fntguide characters. There are three complementary methods to set font attributes in LaTeX math mode: The OML encoding contains italic Fntguide and Greek letters fntguide use in fnguide fntguide typically used for fntguiee together with some symbols.
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A sans math version example is available from a comp. Optionally add an fntbuide Math alphabets Math alphabets fntguide a counterpart to fntguide mathematical alphanumeric symbols fntguide in Unicode. At least three taxi companies service the airport.
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German Shepherd Rescued from River Channel Watch this heroic rescue of German Shepherd Biggie from a flood channel. This amazing effort was organized by Hope For Paws rescue organization.
German Shepherd Being Rescued Watch the transformation this German Shepherd goes through when he gets trapped into a cage. The rescue was beautiful and went through as planned.


Did you know that on November 21, 2014, the UN adopted a resolution on combating glorification of Nazism? You might even know that this resolution was adopted on the initiative of Russia?
Do you know what countries were against the adoption of the resolution? Opponents of the resolution were the United States, Canada and Ukraine. European Union countries abstained. However, it would be strange to expect any other reaction from the countries occupied by the United States of America.
Why against this resolution was Ukraine's understandable. After all, the current government of Ukraine is fascist, burned people in Odessa, and killing people in Donetsk and Lugansk. The power bombarding the city with the civilians of rocket launchers.
Why against the resolution were Canada, too it is possible to guess. It is in Canada lives many children and grandchildren of the murderers of the Ukrainian nationalist troops. But why against were the United States of America?
Maybe because America loves a fascist ideology? After all, who but the fascists can say that his country is "exceptional"? And Obama called America exceptional 24 September 2013. It is America that believes that they have the right to bomb other countries. It is America decided to train Ukrainian military, although the government of Ukraine is at war with its own people.
By the way, European Newspapers have fond memories of that Russia allegedly invaded Crimea. Although, actually in Crimea, a referendum was held, after which the Crimea seceded from Ukraine. And only a week later, the Crimea was adopted in Russia. But for some reason European Newspapers do not write about the fact that in the Ukrainian city of Odessa burned alive people. Not European Newspapers write about the fact that Ukraine prohibit the veterans to carry the flag and some medals. European Newspapers are trying to deceive the readers and not specifically written about many things that will not appeal to the residents of their countries.
I think that Europeans should stop trying to preserve our democracy, and think, and do they have this democracy?
When in Ukraine, the Americans forbade the President to use arms against the demonstration, it was a democracy? Or democracy was the fact that the "peaceful" protesters set on fire and beaten with pipes Ukrainian militiamen (policemen)? Then why called democracy and the use of weapons against protesters in America people?
Why the disintegration of Yugoslavia, America says is right, and the separation of Crimea from Ukraine America thinks wrong? But because America was favorable destroyed Yugoslavia, and America needed the Crimea as part of Ukraine, to put the American fleet and threaten Russia.
Why is America constantly said that Russia deployed its army in Ukraine? And why they refuse to prove it? After all, America has the largest number of reconnaissance satellites. Why is America a couple of times gave satellite images, which later turned out to be fake? It is obvious that America simply is no evidence! Because Americans want Russia began fighting in Ukraine, and Russia refuses to fight. Any intelligent person understands that Russia would not demand negotiations and to offer the Minsk agreement, if Ukraine were Russian troops.
America wants to discredit Russia. America really wants Russia was weak. However, Americans do not understand that the Russian people in this situation do not panic, but rather, become more cohesive. While American and European sanctions have provoked the Russians just laugh.
However, the Americans have another habit. They are often brought up in the country they need the government, and then suddenly declare that this government is not democratic and begins bombing the country. So the Ukrainian government should not deceive ourselves. However, as the best friends of America in Europe (Poland and the Baltic States).


text:
UK launches air strikes on ISIL targets in Syria
British jets carry out air raids just hours after parliament passes motion authorising use of force against group.
Warplanes struck ISIL just hours after parliament approved Cameron's motion [File:RAF/EPA]
British fighter planes have struck suspected ISIL targets in Syria, just hours after MPs approved a motion authorising the use of military force against the group.
A British Ministry of Defence spokesman confirmed to Al Jazeera that Tornado jets had returned to base after conducting combat missions against the group on Thursday.
In a statement released later on Thursday, the ministry said the raids were conducted in coordination with aircraft from allied states, striking ISIL oil interests,
The jets "employed Paveway IV guided bombs to conduct strikes against six targets within the extensive oilfield at Omar, 35 miles (56km) inside Syria's eastern border with Iraq," the statement said.
OPINION: 7/7 Survivor: Why we should not bomb Syria
The strikes come just hours after UK Prime Minister David Cameron successfully passed a motion authorising strikes in Syria, with 397 MPs voting in favour, and 223 voting against.
Cameron was backed by dozens of Labour MPs who broke ranks with leader Jeremy Corbyn, who is opposed to the military intervention.
Addressing parliament on Wednesday, Cameron said high-precision, laser-guided Brimstone missiles attached to the Tornado GR4 bombers would help to make a real difference by hitting the ISIL capital of Raqqa and its oil-trading business.
France and the US are already bombing the fighters in Syria, while Russia has bombed mainly other armed groups battling the forces of Syrian President Bashar al-Assad.
Cyprus, which lies about 100km away from Syria, is the closest European Union member state to turmoil in the Middle East.
UK parliament votes to launch air strikes in Syria
What the British military really contributes in Syria
British Parliament will vote on Wednesday on whether it should extend RAF strikes in Iraq and Syria.
UK plan to strike ISIL in Syria divides MPs
Opposition leader Jeremy Corbyn has allowed Labour MPs to vote for strikes against ISIL despite personal opposition.
English-speaking Syrians see UK as multicultural haven
Liberal tradition, multiculturalism, religious tolerance and job opportunities make Britain an attractive option for refugees.

redpajama_set_name: RedPajamaCommonCrawl


Will this work on Ubuntu?
Yes, as it is a derivative from debian and uses apt-get the script will work.
One word: Magic! Actually at the moment all the packages are downloaded with apt-get. But in the future it will be possible to add script packages.
How can I add packages?
At the moment you can only download the few packages which are provided by default. I'm working on the feature to add packages manually.


When choosing the data type for a given screen variable, i often have the need to choose a Record List of 'something' data type. If i have many Entities/Structures, i have to scroll down all the way to choose both List and Record data type. The idea is to have the most chosen data types in the beginning of the popup.
You can always search for "record" or "list" and it shows those options.
record list? i do hope you mean simple list.
We don't have short term plans to tackle this but we will keep it to be considered in the future.


Please note that SLOCEA's office will be Closed on Tuesday, February 12, 2019, in observance of the County Holiday. Your SLOCEA staff wishes all of our members a safe and relaxing Holiday! For those who have to work, thank you for your dedicated service to the Public!


Collooney, Ballymote and Williamstown will host an action packed day of colleges handball this Saturday 20th October when all of the 2nd level Colleges SF's and Finals are down for decision. Play will kick off at 10.30am, with the finals scheduled to start from approx. 2pm onwards.


text:
Q: Streaming files directly to users I am creating a download script that will allow me to allow users to download files that may be sitting on my server locally or on a remote server. In both cases, I do not want the user to find out the original file location.
In the case of my file being on my server, its easy:
$data = file_get_contents('/local/path');
$name = 'myphoto';
force_download($name, $data); //codeigniter

However, for remote files, if I do this:
$data = file_get_contents('/remote/path');
$name = 'myphoto';
force_download($name, $data);

It will download to my server first, which is going to delay the download for the user.
Is there a way I can stream any file somehow through my server to the user? So it starts downloading straight away? Possible?

A: Look at fpassthru: it'll take a bit more than what you have, but it should do what you want.
You'll want something like this:
    $fp = fopen('/remote/path');

    // you can't use force_download($name, $data): you'll need to set the headers
appropriately by hand: see the code for the download_helper, but you'll need to set the mime type and content-length if you really care.

    header('Content-Type: "'.$mime.'"');
                        header('Content-Disposition: attachment;filename="myphoto"');
                        header("Content-Transfer-Encoding: binary");
                        header('Expires: 0');
                        header('Pragma: no-cache');
                        header("Content-Length: ".strlen($data));
    fpassthru($fp);

redpajama_set_name: RedPajamaStackExchange


text:
Catherine Kullmann - Author
A Suggestion of Scandal
Perception & Illusion
The Murmur of Masks
The Duke's Regret
The Potential for LOVE
The Zombi of Caisteal Dun
My Scrap Album
The Regency Decade—1814, Part One: Frost, Fraud and the Fall of Paris
1814 was so eventful a year that one post cannot do it justice. This post takes us up to 31 March, the day Paris fell. Napoleon's days as Emperor were now numbered.
At the turn of the year, fog shrouded the British Isles. This later gave way to a bitter week-long cold spell bringing snow and ice. Supplies became scarce as roads remained closed and the price of coal soared. The Cambridge mail coach was snowed up and completely covered for almost eight hours. It took fourteen waggon-horses to drag it out. Amazingly, the passengers survived though 'almost frozen to death'. There is no mention of the fate of the coachman—it is possible he continued the journey on horseback to deliver the mails and seek assistance.
At the end of January, the Thames froze to such a depth that a Frost Fair could be held on it and all the usual entertainments of a fair—swings, book-stalls, drinking and eating booths, dancing, skittles, knock-em-downs, wheels of fortune, and gaming tables were soon to be found on the frozen river. Printers set up their presses, selling commemorative pieces printed 'on the Ice' to the thousands promenading on the central footpath or 'City Road'.
By the fifth of February it was all over. When the thaw set in, blocks of broken up ice swept light craft and barges that had been imprisoned by the frost. inexorably down river, causing considerable damage and some loss of life.
On 21st February, news reached London that the Allies had secured a great victory over Napoleon who had been slain by the Cossacks and that the Allied Sovereigns (the Tsar of Russia and the King of Prussia) were in Paris. The price of Government Omnium stock rose sharply, only to fall again when it became apparent that there had been no victory and that the whole thing was 'Fake News', a deliberate fraud by Charles Random de Berenger who, having posed as the bearer of important despatches from France, posted to London with horses decked with laurels.
Caught up in this Great Stock Exchange Fraud, as it came to be known, was Lord Cochrane, a renowned naval captain, Member of Parliament and eldest son and heir of the Earl of Dundonald, who had profited from the short surge in the price of omnium. Despite his protests that his stockbroker was acting on his standing instructions to sell Omnium if the price rose by one percent, he was convicted of complicity, fined a thousand pounds and sentenced to twelve months imprisonment in the Marshalsea. Before serving this sentence, he was to stand in the pillory for one hour. This last was afterwards remitted but a devastating social pillorying followed. His name was struck off the Navy list, he was expelled from the House of Commons, his arms were taken down from his stall as Knight of the Bath and his banner torn down and kicked ignominiously out of Henry VII's Chapel in Westminster Abbey.
Many believed Lord Cochrane innocent and in the subsequent by-election he was re-elected to his seat in Parliament which he took the day he was released from prison. He continued to fight for the restoration of his good name and in 1832 received a 'free pardon'; was restored to the Navy List, gazetted a rear-admiral and attended a levée at court. In 1847, his knighthood was restored and he was created a Knight Grand Cross of the Order of the Bath. He died in 1860. The day before his funeral, his banner was returned to Westminster Abbey where he is buried.
In 1876 his grandson received a payment of £40,000 from the British government, based on the recommendations of a Parliamentary select committee, in compensation for Cochrane's conviction which was believed to be unjust.
Lord Cochrane 1807
On 31 March, Ekaterina Pavlovna, the widowed Duchess of Oldenburg, arrived in England. She entered London in great state, travelling in the Prince Regent's own carriage and escorted by the Duke of Clarence who had met her at Sheerness. Although her visit was said to be a private one, it was generally assumed that she had been entrusted with a political mission. As she travelled to Britain, the Allied Armies, led by her brother the Tsar and the King of Prussia were advancing on Paris. Following a two-day battle, Paris surrendered on 31 March and the same day the Allied Sovereigns triumphantly led their troups into the city.
The Russian Army enters Paris
To read previous posts in the Regency Decade series, either scroll down or click on The Regency Decade in the righthand margin.
Davida Chazan link
The novel "The Summer Country" takes place partially during this time period.
Mary Bradford link
I loved this post. Wonderful to read about history that I never would seek out, I really enjoyed this piece, so interesting.
Categories
An Off Stage War
An Off-Stage War
Between Hoops And Crinolines
Matrimonial Map
My Reference Library
Regency Personalities
The Matrimonial Ladder
The Regency Decade
The Way They Lived Then
Copyright © Catherine Kullmann - All rights reserved
Matrimonial Map Courtesy of the National Library of Ireland


All In A Days Work Personal Checks - For these cowboys dusty jeans, calloused hands and long rides are All in A Days Work. In four varying check scenes, you'll saddle up next to these hard working cowboys and share the adventures on the open range. With beautiful blue-sky backdrops, golden grassy fields, and mountain tops in the distance, this check series will make you feel your right on ranch.


Coffee table ottoman the reclaimed wood round coffee table ideas. Coffee table ideas. Round coffee table ottoman the reclaimed wood round coffee table ideas. With storage designs square rustic buy reclaimed wood round coffee table with storage designs square rustic buy reclaimed wood round coffee table with storage designs square rustic buy reclaimed wood round coffee table ottoman the reclaimed wood round coffee table with storage designs square rustic buy reclaimed wood round coffee table ottoman the reclaimed wood round coffee table with storage designs square rustic buy reclaimed wood round coffee table with storage designs square.


text:
Ireland Commits 5.6 million to Fishing Industry Training
Politics Economics Sustainability Environment
21 July 2015, at 1:00am
IRELAND - The Irish government has allocated 5.6 million to training in the fishing industry to 2020. The commitment comes as the Minister for Agriculture, Food and the Marine, Simon Coveney, welcomed the publication of a report on Safety, Training & Employment in the Irish Fishing Industry.
The working group chaired by Lt Cdr John Leech, Chief Executive, Irish Water Safety, was set up by the Minister to examine a range of important issues for Ireland's fishing industry such as safety standards and training on board vessels, compliance with regulations, recent technical innovations and the fishing sector's approach to personal safety.
In its parallel work, the Working Group also considered options for making the fishing industry safer and more attractive, economically, as a career option for potential new entrants, bringing forward recommendations for improving career structures and the provision of opportunities for lifelong learning.
Central to the working groups recommendations on improving safety in the industry, is the need for significant culture change across the fisheries sector.
Commenting on the report, the Minister stated: "We need to ensure that the concept of safety at sea, and on the water generally, becomes as commonplace and habitual as safety on our roads. While this report brings forward many recommendations across its broad ranging terms of reference, the central message to come from the work of this group, is the need for permanent culture change in the fisheries sector. Vessel operators, skippers and crew members need to work together so that a safety first culture becomes the norm and the safety of both vessels and personnel is prioritised."
The Minister went on to say: "I am making an additional €5.6m available to the fisheries catching sector for training and skills development under the European Maritime and Fisheries Fund (EMFF) 2014-2020 Operational Programme. This extra funding will be instrumental in addressing recommendations in the report and driving a culture change to enhance safety across the fisheries sector."
The group identified the wearing of Personal Flotation Devices (PFDs) as being critical to reducing fatalities and the need for constant vigilance, regarding the challenges and dangers inherent in working at sea and on island waterways.
The Working Group report also highlights the need for Ireland's existing maritime regulations to be fully observed and the need for safety-training practices to be augmented to include mandatory certificates of Competence, for both operators and crew/deckhands on all vessels, vessel 'stability' training and work-related safety, survival, fire and first aid procedures, targeted initially at operators of vessels less than 24 metres in length where the majority of recent fatalities have occurred.
In its parallel work of examining possibilities for improving the attractiveness of the fishing industry as a career option, the Working Group has brought forward a number of recommendations, aimed at improving the training incentives and career structures within the industry.
In one of its principal recommendations in this area, the Working Group identifies the introduction of more tailored social-protection provision as one of the most significant negative factors in retaining qualified and experienced personnel in the fishing industry and advocates significant changes to the existing provisions for those working in the fishing industry. Other important recommendations in this area focus on the need for lifelong learning and the development of career diversification paths, to reflect the complex demands of the modern industry.
Minister Coveney concluded by saying: "I would like to thank the individual members of the Working Party and Ltd Cdr John Leech for the good work they have done in bringing this Report to fruition. I expect the Report will lead to substantial positive change in the industry over time."
Women in aquaculture: Lara Barazi
Lara Barazi has been CEO of Kefalonia for 22 years, in the process growing production volumes of certified organic seabass and sea bream from 300 to 5,000 tonnes a year.


text:
La Chapelle Sainte Tulle est une chapelle romane, sur la commune de Sainte-Tulle, dans les Alpes-de-Haute-Provence.

Architecture
De base rectangulaire, la chapelle Sainte-Tulle est de style roman. Sa particularité est la présence d'une crypte, fait rare pour une chapelle rurale. Des travaux de remaniement ont eu lieu en 1892, au niveau de l'abside et de la porte d'entrée.

Histoire
Initialement rattaché à un prieuré fondé par l'Abbaye Saint-André de Villeneuve-lès-Avignon, cette chapelle date du . Depuis cette date, elle a maintes fois servi de lieu de pèlerinage à Sainte-Tulle, notamment lors de la peste de 1720, ainsi que lieu de sépulture.

La chapelle est inscrite au titre des monuments historiques en 2011.

En savoir plus

Notes et références

Articles connexes
 Liste des monuments historiques des Alpes-de-Haute-Provence

Liens externes

Sainte-Tulle
Monument historique dans les Alpes-de-Haute-Provence
Monument historique inscrit en 2011
Chapelle monument historique (France)
Sainte-Tulle

redpajama_set_name: RedPajamaWikipedia


text:
Comparative Constitutional Reasoning
by András Jakab, Giulo Itzcovich and Arthur Dyevre
András Jakab
Giulo Itzcovich
Arthur Dyevre
To what extent is the language of judicial opinions responsive to the political and social context in which constitutional courts operate? Courts are reason-giving institutions, with argumentation playing a central role in constitutional adjudication. However, a cursory look at just a handful of constitutional systems suggests important differences in the practices of constitutional judges, whether in matters of form, style, or language. Focusing on independently-verified leading cases globally, a combination of qualitative and quantitative analysis offers the most comprehensive and systematic account of constitutional reasoning to date. This analysis is supported by the examination of eighteen legal systems around the world including the European Court of Human Rights and the European Court of Justice. Universally common aspects of constitutional reasoning are identified in this book, and contributors also examine whether common law countries differ to civil law countries in this respect.
Laws of Specific jurisdictions Courts & procedure Comparative law Systems of law Constitutional & administrative law International law
Be the first to review Comparative Constitutional Reasoning.


Aircraft hangar fire protection systems have numerous and often times complex code requirements. The wide array of design choices and installation requirements must be carefully weighed to find the most cost-effective and code compliant system to protect your high-value aircraft.
Bender Modlin has qualified professionals and the proven experience to handle your aircraft hangar fire protection design, installation, and service needs.
If you would like to learn more about aircraft hangar fire protection, contact one of our team members today!


text:
Employers' obligations regarding gender pay gap reporting
The start of the new financial year often heralds change in employment legislation and 2017 was no different with the introduction of the gender pay gap reporting. Under the new law any voluntary, private or public sector company with 250 or more workers has to publish its annual gender pay data.
What do employers have to provide?
Employers must publish data on the following six criteria:
mean gender pay gap in hourly pay
median gender pay gap in hourly pay
mean bonus gender pay gap
median bonus gender pay gap
proportion of males and females receiving a bonus payment
proportion of males and females in each pay quartile
The results must be published on the employer's public facing website and also a government website by no later than April 2018 and then each year after that.
Are there consequences for non-compliance?
As set out above, employers have a statutory duty to produce their figures by no later than April 2018. However, somewhat surprisingly, there is no legislative sanction for non-compliance. Some have argued that the bad publicity associated with a failure to comply will be enough to encourage employers to produce the figures. However some are concerned that the lack of direct punishment risks letting unscrupulous employers off the hook.
Importantly, employers have the option of providing a narrative alongside their data. This gives them the opportunity to explain any misleading impressions which the bare figures might give and also provides them with a chance to explain the steps they intend to take to bring about greater equality.
The move will bring about greater transparency and hopefully reduce the gender pay gap which recent Office for National Statistics figures confirm still exists today. For example, if the figures demonstrate an under representation of women at senior level then this may provide the shot in the arm for employers to take action.
More Claims?
We will have to wait and see whether the introduction of gender pay reporting will bring about further claims. ACAS has been keen to make a distinction between gender pay reporting and equal pay.
The equal pay legislation focuses on the pay differences between men and women who carry out "like work" and give workers the right to bring claims where there are discrepancies. Whilst gender pay gap reporting casts the net wider, considering the differences across the entire workforce, it does not immediately give rise to claims.
Despite the distinction, it is felt that the greater transparency will lead people to compare themselves with their colleagues, highlight differences they may not be aware of, and re-evaluate their position within company. This may in turn give rise to an increase in employment disputes and tribunal claims.
Consumer & Dispute Resolution
Court of Protection - Healthcare & Social Services
Criminal Defence & Appeals
Motoring & Haulage
Redundancy procedures - what you need to know
Flexible working for parents and carers - Covid-19
Supporting SMEs with redundancy reality
Managing personal relationships in the workplace
The new job support scheme doesn't go far enough


text:
Q: Fastest performance with DELETE logic NOT IN nested query I'm trying to get the fastest performance for this DELETE (and SELECT) query.  Is there a better way to DELETE the records, because this takes over 10 minutes to run?  I imagine it has to do it's own sort and merge until it can find the records.
SELECT COUNT([VISIT_ID])
FROM [dbo].[I2B2_SRC_VISITS]
WHERE [PATIENT_ID] NOT IN (
    SELECT [PATIENT_ID] FROM [dbo].[I2B2_SRC_PATIENT]
)

DELETE FROM [dbo].[I2B2_SRC_VISITS]
WHERE [PATIENT_ID] NOT IN (
    SELECT [PATIENT_ID] FROM [dbo].[I2B2_SRC_PATIENT]
)

EDIT: I couldn't put the DELETE in front of that query like I did with the SELECT.  But this was the end result for the DELETE statement.
DELETE FROM [dbo].[I2B2_SRC_VISITS]
WHERE [VISIT_ID] IN
(
    SELECT a.[VISIT_ID]
    FROM    [dbo].[I2B2_SRC_VISITS] a
            LEFT JOIN [dbo].[I2B2_SRC_PATIENT] b
                ON a.[PATIENT_ID] = b.[PATIENT_ID]
    WHERE b.[PATIENT_ID]  IS NULL
)

A: how about doing it via JOIN?
DELETE  a
FROM    [dbo].[I2B2_SRC_VISITS] a
        LEFT JOIN [dbo].[I2B2_SRC_PATIENT] b
            ON a.[PATIENT_ID] = b.[PATIENT_ID]
WHERE   b.[PATIENT_ID] IS NULL

Make sure that column [PATIENT_ID] from both tables has key define on them which makes it more faster.

Right. NOT EXIST is better one.
DELETE  a
FROM    [dbo].[I2B2_SRC_VISITS] a
WHERE   NOT EXISTS
        (
            SELECT  1
            FROM    [dbo].[I2B2_SRC_PATIENT] b
            WHERE   a.[PATIENT_ID] = b.[PATIENT_ID]
        )


text:
Women's and Children's Services
Mutations in the ribosome biogenesis factor gene LTV1 are linked to LIPHAK syndrome, a novel poikiloderma-like disorder
Helbling, Ingrid
Barwell, Julian
100000 Genomes
LTV1-associated Inflammatory Poikiloderma with Hair abnormalities and Acral Keratoses
LIPHAK syndrome
ribosomopathy
https://academic.oup.com/hmg/advance-article/doi/10.1093/hmg/ddab368/6498461
In the framework of the UK 100000 Genomes Project, we investigated the genetic origin of a previously undescribed recessive dermatological condition, which we named LIPHAK (LTV1-associated Inflammatory Poikiloderma with Hair abnormalities and Acral Keratoses), in four affected individuals from two UK families of Pakistani and Indian origins, respectively. Our analysis showed that only one gene, LTV1, carried rare biallelic variants that were shared in all affected individuals, and specifically they bore the NM_032860.5:c.503A > G, p.(Asn168Ser) change, found homozygously in all of them. In addition, high-resolution homozygosity mapping revealed the presence of a small 652-kb stretch on chromosome 6, encompassing LTV1, that was common to and haploidentical in all affected individuals. The c.503A > G variant was predicted by in silico tools to affect the correct splicing of LTV1's exon 5. Minigene-driven splicing assays in HEK293T cells and in a skin sample from one of the patients confirmed that this variant was indeed responsible for the creation of a new donor splice site, resulting in aberrant splicing and in a premature termination codon in exon 6 of this gene. LTV1 encodes one of the ribosome biogenesis factors that promote the assembly of the small (40S) ribosomal subunit. In yeast, defects in LTV1 alter the export of nascent ribosomal subunits to the cytoplasm; however, the role of this gene in human pathology is unknown to date. Our data suggest that LIPHAK could be a previously unrecognised ribosomopathy.
Han, J. H., Ryan, G., Guy, A., Liu, L., Quinodoz, M., Helbling, I., Lai-Cheong, J. E., Genomics England Research Consortium, Barwell, J., Folcher, M., McGrath, J. A., Moss, C., & Rivolta, C. (2022). Mutations in the ribosome biogenesis factor gene LTV1 are linked to LIPHAK syndrome, a novel poikiloderma-like disorder. Human molecular genetics, ddab368. Advance online publication. https://doi.org/10.1093/hmg/ddab368


Dogs can suffer from a whole host of diseases and other serious health problems. Some of these conditions are inherited, while others are caused by viruses; still others are related to lifestyle and environmental influences.
When you decide to get a dog, you are doing so with the expectation that your new canine companion is going to be with you for many years to come. But how many years, exactly? This is something that all prospective pet owners would like to know. The average lifespan for a dog is about 12 years, but this fact by itself tells you very little. In reality, there are a number of variables that will help determine how long the newest member of your family is likely to be with you.