Here is our Match Report from Tuesday evening's Sky Bet League One clash between Walsall and hosts, Plymouth Argyle.
Dean Keates' Saddlers arrived at the match on the back of Saturday's encouraging three-nil victory over Gillingham, a match which saw summer signing Andy Cook grab a well-deserved treble to secure the points for his side.
Plymouth Argyle started the game brightly, making an early dart for the Walsall box, with Graham Carey looking to set Freddie Ladapo up, but the Saddlers defences were alert and Cameron Norman cleared the danger.
The host continued to push forward in the early goings, almost finding a route through on goal six minutes in as a cross from Ruben Lameiras was deflected across the Walsall box, with the Saddlers a little fortunate that none of his Argyle team-mates were able to get on the end of it to turn it home.
Walsall dug in in the wet conditions, defending well before working the ball up to the other end, where they created the first real chance of the game after winning a free-kick in a dangerous position, which Luke Leahy curled into the box. Josh Gordon got his head to the in-swinging ball, but Kyle Letheren pulled off a fine save to deny him. The resulting corner was worked to Andy Cook at the back post, but the striker sliced an effort, which was comfortably saved.
Argyle soon had the ball back up at the other end, where a foul from Connor Johnson on Ruben saw them awarded a dangerous free-kick of their own. Yann Songo'o went close from the set-piece, but his headed, six yard effort sailed harmlessly over the crossbar when he really ought to have scored. The home side continued to press though, with Lameiras seeing a left-footed effort blocked in the sixteenth minute.
The game settled a little as the rain eased, but Argyle worked the ball forwards in the twenty-third minute, winning a corner which Niall Canavan headed over the crossbar without troubling Liam Roberts in the Walsall goal.
With twenty-six minutes on the clock, Isaiah Osbourne picked up the first booking of the game, seeing yellow for a sliding tackle on Ruben. The resulting free-kick, saw Carey work the ball to Ruben, who sliced an effort wide.
The visitors soon had the ball back in the Argyle half, winning a free-kick which the home defences cleared only as far as Walsall captain, Joe Edwards who fired an effort in from the edge of the box, but the ball sailed high and wide.
Thirty-six minutes in, Plymouth won a corner as Nicky Devlin was forced to divert a Gary Sawyer effort behind, but the flag-kick came to nothing with the Saddlers continuing to defend well.
The hosts continued to search for an advantage before the break, with Songo'o going close in the thirty-ninth minute. His headed effort from the centre of the box sailing inches wide of Roberts' upright.
Walsall won a corner with just a minute of the first-half remaining, as David Fox was forced to head a dangerous looking cross behind. Leahy fired a curling cross into the box from the flag-kick, which found Jon Guthrie, but the defender put too much on his close range effort, sending the ball sailing over the crossbar.
One additional minute was added to end the first-half, but neither side was able to make use of the time, and the teams headed back to their respective dressing rooms with the scores still tied.
The teams returned unchanged after the break, and the second-half got underway. Walsall began the half brightly, creating a chance for Osbourne to open the scoring just two minutes after the re-start, but his right-footed effort from the centre of the box sailed narrowly wide.
Three minutes later, the hosts went close from a corner which found Ladapo waiting at the back post, but the striker was unable to control his shot, sending the ball out for a goal-kick.
Argyle were more fortunate four minutes later, winning a free-kick which was played into the box by Carey, where Ryan Edwards was on hand to head into the bottom right corner from close range to put his side ahead.
Walsall were quick to work the ball the ball back up to the other end, where Gordon and Matt Jarvis combined well before seeing an effort diverted behind. The resulting corner was played to Norman at the back post, but the defenders header clipped the post.
With fifty-seven minutes played, Josh Gordon became the second player to see his name entered into the referee's notebook, picking up a yellow card for a foul on Songo'o.
Plymouth doubled their advantage in the sixty-fifth minute, winning a free-kick in a dangerous position, which Carey played onto the head of Canavan who was waiting in the centre of the box to turn the ball home.
The hosts went close again two minutes later, with Songo'o seeing a right-footed effort from the edge of the box deflected behind by the Walsall captain. The resulting corner came to nothing.
Twenty minutes from time, the Saddlers opted to make a double change to their line-up, with Joe Edwards and Nicky Devlin making way for Zeli Ismail and George Dobson as the side looked to get back into the game.
Moments later, Plymouth opted to make their first change of the evening, introducing Ryan Taylor into the fray in place of Antoni Sarcevic.
Five minutes after making their first two changes, the Saddlers threw caution to the wind, making their third and final change of the evening, as Matt Jarvis made way for Liam Kinsella.
Seconds after the substitution, Cook went close for the Saddlers. A delightful cross finding the striker unmarked at the back post, but his headed effort sailed narrowly wide of Letheren's upright.
With eighty-two minutes on the clock, Cook made up for the miss with a brilliant piece of individual skill, bringing the ball down on the edge of the box before passing several defenders and firing a low effort past Letheren to bring his side to within a goal of their hosts.
Two minutes later, Leahy almost drew the sides level after some good work from Cook and Gordon set him up at the back post, but the defender was unable to keep his effort on target, with the ball sailing over the bar.
The hosts felt they should have been awarded a penalty in the eighty-seventh minute, as Taylor was felled inside the box, but the referee was unmoved by their appeals and waved play on.
In the final minute of regulation time, Yann Songo'o found his way into the referee's notebook, picking up a yellow card for a foul on Gordon.
Four additional minutes were played to end the game, but neither side was able to create any further chances of note. The two goals from set-pieces enough to ensure all three points would remain on the south coast. A disappointing way for the Saddlers to follow-up Saturday's superb performance.


text:
Category: B=Bad Movie?
The Sad Tragic Fate Of Veronica Lake | National Enquirer
By DICK SIEGEL, NATIONAL ENQUIRER online editor Jan 22, 2015 @ 5:33AM
Femme fatal film icon VERONICA LAKE fell from Hollywood heights to waiting tables in a sleazy women's only hotel before succumbing to the ravages of alcoholism and mental illness at only age 50.
Veronica Lake was born in Brooklyn, New York on November 14, 1922 as Constance Frances Marie Ockleman. Her father worked for an oil company as a ship employee and died in a tragic oil tanker explosion.
Her ethereal beauty, natural charm coupled with a talent for acting prompted her mother and tubercular step-father to move to Beverly Hills, California, where they enrolled her in the Bliss Hayden School of Acting in Hollywood.
Although Connie had been previously diagnosed as a classic schizophrenic her parents saw acting as a form of treatment for her condition. She soon found work as a bit player in several unremarkable pictures but "Sorority House" director John Farrow (Mia Farrow's father) saw how her long flowing hair always covered her right eye, creating an hint of allure and mystery. While still a teenager, Farrow introduced her to Paramount producer Arthur Hornblow who promptly changed her name to Veronica Lake.
Veronica's breakthrough film was "I Wanted Wings" in 1941, a major box office hit.
She then became Paramount's top female star toplining such classics as "Sullivan's Travels", "This Gun for Hire", The Glass Key", "So Proudly We Hail" and "I Married A Witch".
"She was a very gifted girl, but shedidn't believe she was gifted," director Rene Clair recalled.
Often paired with diminutive star Alan Ladd, the couple made seven films together. At first it was out of necessity as Ladd was just 5 feet five while Lake was 4 feet 11 inch but the pair had undeniable on-screen chemistry
For a short time during the early 1940s, Veronica was at the height of Hollywood stardom.
During World War Two, the rage for her peek-a-boo bangs became a hazard when women in the defense industry would get their hair caught in machinery. Lake was staged in a publicity picture in which she reacted painfully to her hair getting "caught" in a drill press illustrating her hazardous 'do. Finally, Lake famously cut her hair and, sadly, her popularity diminished.
By the early 1950's Lake's career had hit the skids.
Still battling schizophrenia, and in a state of paranoia, she began drinking heavily. As her mental state deteriorated further, with two failed marriages, Veronica became manic-depressive as her self-destructive addiction to booze pushed her over the edge.
Soon, with no film career and little alimony after an IRS forced bankruptcy, Lake drifted between cheap hotels in New York City. She was arrested several times for public drunkenness and disorderly conduct.
In 1963, a reporter found her working as a barmaid/waitress while living at the seedy all-women's $7-a-night Martha Washington Hotel in Manhattan. In the hotel bar, Lake was working under an alias — Connie De Toth ("House of Wax" director Andre DeToth had been her second hubby).
Lake had never revealed her true name to her co-workers nor customers although her boss Joe Rauji at the Colonnade Bar knew who she was. "She's a good girl but she's had a hard time," he told a reporter.
Lake later toiled at other bars including Greenwich Village's famed One Fifth getting a steady paycheck and a never ending stream of booze.
The widely circulated news reports of her plight led to some minor TV and film work but Lake soon made a financial comeback by penning her memoirs.
With the profits from her best selling tell-all, Lake co-produced and starred in her last film, "Flesh Feast" (1970), a micro-budget horror movie with a Nazi-myth storyline. It bombed.
After another failed marriage and brief sojourn in England, Lake returned home.
She was already "pretty far along" when she was admitted to the Fletcher Allen Hospital in Vermont, doctors said.
Finally, in the early morning hours of July 7, 1973, Veronica Lake died from hepatitis and acute renal failure — seemingly alone and forgotten at the age of 50.
That is, until the news broke, when suddenly EVERYONE remembered.
Posted in b movies, B=Bad Movie?, Brad Grinter, Camp, Cool Cinema Trash, Everyone's a Critic, exploitation, Florida, Florida Film History, Florida Filmmaking, Floridasploitation, Goddammit 1970s!, Hagsploitation, Hitler, Movie Blogs!, Movie Marathon, Only in the 70s!, RIP, Six Degrees of Stoogeration!, Something Awful, The 50 Worst Movies, Who Loves Ya 70s?, William Grefe, Z Fest!Tagged Flesh Feast, If This Is The Last Thing I Ever Do, Swan Songs, The National Enquirer, Veronica Lake
Day 1 of 31 Days of Terror! Dancing Away to the "Point of Terror"
Point of Terror Year: 1971 Genre: Horror, Thriller Director: Alex Nicol Stars: Peter Carpenter, Dyanne Thorne, Lory Hansen A nightclub singer has nightmares about being involved in adultery and mur…
Source: Dancing Away to the "Point of Terror"
Posted in 31 Days of Horror!, 70s Bad!, B Movie Graveyard, b movies, B=Bad Movie?, Dyanne Thorne, Peter Carpenter, Point of Terror, UncategorizedTagged Alex Nicol, Dyanne Thorne, horror, Lory Hansen, nightclub singer, Point of Terror, thriller
Drive-In Movie Madness: Vintage Ads & Marquees via Flashbak
via Drive-In Theater Memories: Vintage Ads & Marquees – Flashbak
Remember the "good old days" at the drive-in? Yeah, me neither. Apparently, I've BEEN to one, but was too young to remember. That would've been 1976, so the tail end of the blaxploitation era and the time before home video would make drive-ins moot. Enjoy the memories (or not!) from Flashbak!
Posted in #Floridasploitation, 366 Weird Movies, 420, 60s Bad!, 70s Bad!, Al Adamson, And You Call Yourself a Scientist, B Movie Graveyard, B=Bad Movie?, Blaxploitation, Columbia Short Subjects, Cool Cinema Trash, DIY MST3K, Flashbak, Goddammit 1970s!, If It's the Last Thing I Do!, If It's The Last Thing I Ever Do, It's MST3K's Fault!, Jabootu, Movie Blogs!, Nazisploitation, Thanks 1950s!, Uncategorized, Who Loves Ya 70s?, William Grefe, William Shatner, Z Fest!Tagged drive-in, Flashbak, vintage ads
March Madness & Movie Mayhem, Day 27 (or, How Ed Wood Isn't the World's Worst Director)
via Ed Wood: Not Actually The Worst Director in History | Den of Geek
How did Ed Wood get the title of "World's Worst Director?" (Then again, we'd also have to ask how William "One Shot" Beaudine was at least the runner-up, even though he was once a highly regarded director.) Of course, we can put most of the blame on the doorstep of the Medveds, who deemed Ed "the worst" with their Golden Turkey tome. I can only imagine that they hadn't seen very many movies from the period they were in, because NONE of the Dolomite movies made the cut, but Trouble Man did?! Why not just throw Super Fly and Shaft in there too, since we're complaining about blaxploitation films with kick-ass soundtracks…
Anyhoo, where was I going with this? Oh, that Ed Wood wasn't the world's worst director–far from it. I can name at least THREE worse directors off the top of my head: Bill Rebane/Herschell Gordon Lewis (Monster-A-Go-Go/Terror at Half Day); Larry Buchanan (Zontar: The Thing From Venus); Coleman Francis (all three of his films); Doris Wishman (Double Agent 73, Let Me Die a Woman); Ted V. Mikels (The Girl in Gold Boots, The Doll Squad)…the list is literally endless!
I think the problem lies with Ed Wood's films being better than "so bad they're good." There's something about Wood's films, even the cringetastic Orgy of the Dead and The Revenge of Dr. X that makes them watchable. You're not yelling at the screen at the stupidity of the writing. (The CLUNKINESS, maybe, but not the stupidity!)
Anyhoo, take a look around the site and enjoy the Den of Geek!
Posted in #Floridasploitation, 366 Weird Movies, 420, 60s Bad!, 70s Bad!, Al Adamson, And You Call Yourself a Scientist, B Movie Graveyard, B=Bad Movie?, Blaxploitation, Brad Grinter, Camp, Certifiable!, cheap, Cinematic Titanic, Cool Cinema Trash, Dead 2 Rights, Den of Geek, DIY MST3K, Drugs Are Bad, Ed Wood Wednesdays, Everyone's a Critic, exploitation, Florida, Florida Film History, Florida Filmmaking, Floridasploitation, Goddammit 1970s!, Hagsploitation, If It's the Last Thing I Do!, If It's The Last Thing I Ever Do, It's MST3K's Fault!, Jabootu, Joe Blevins, March Madness & Movie Mayhem, March Madness and Mayhem Blogathon!, March Movie Madness & Mayhem, March Movie Madness!, Movie Blogs!, Movie Marathon, Movies Silently, Nazisploitation, Oldsploitation, Only in the 70s!, resolutions, Richard Nixon, RIP, Senses of Cinema, Site of the Week, Six Degrees of Stoogeration!, smartphones, smug, Song-Poem, technology, Thanks 1950s!, The Bad Movie Report, The Horn Section, The IT Factor!, The Last Drive In, The Last of the Red Hot Introverts, the Three Stooges, The Uranium Cafe, The Wonderful and the Obscure, Thrilling Days of Yesteryear, Uncategorized, Who Loves Ya 70s?, Will Someone PLEASE Think of the Children?!Tagged Blaxploitation, Coleman Francis, Ed Wood, Golden Turkey, Medveds, soundtracks, Super Fly, Trouble Man, Uwe Boll, William "One Shot" Beaudine, William Beaudine, William Rebane, Worst Director of All Time
March Madness & Movie Mayhem, Day 26! Mr. No Legs – 1979 – Review
via Mr. No Legs – 1979 – Review
If you have lots of free time on your hands, take a look at the wonderful time-wasting site The Worst Movies Ever Made. Now, "worst" is in the eye of the beholder, but holy gee whiz…this one's bad. Not even the ever-present John Agar or Richard Jaeckel can help this turkey. And when you finally get to see the title character, look out!
Posted in #Floridasploitation, 366 Weird Movies, 70s Bad!, Annoyances, b movies, B=Bad Movie?, Bleeding Skull!, Camp, Certifiable!, cheap, Cool Cinema Trash, Dead 2 Rights, DIY MST3K, Drugs Are Bad, Ed Wood Wednesdays, Expert, Expertise, exploitation, Florida, Florida Film History, Florida Filmmaking, Floridasploitation, guru, Hagsploitation, It's MST3K's Fault!, March Madness & Movie Mayhem, March Madness and Mayhem Blogathon!, March Movie Madness & Mayhem, March Movie Madness!, Monetizing, Movie Blogs!, Movie Marathon, Oldsploitation, Only in the 70s!, pay phones, Retro blogs, Richard Nixon, RIP, Six Degrees of Stoogeration!, smug, Thrilling Days of Yesteryear, Uncategorized, Up In Smoke, Who Loves Ya 70s?, Will Someone PLEASE Think of the Children?!, Z Fest!Tagged John Agar, Rance Howard, Richard Jaeckel, Ricou Browning, The Creature From the Black Lagoon
March Madness & Movie Mayhem (Day 20!)–Octaman
via » Octaman (1971)»Monster Shack Movie Reviews
Hoo, boy! Is this a stinker, or is this a stinker? In fact, it stinks so badly, the star of the film didn't live long enough to see it completed! Pier Angeli committed suicide before filming was completed. Now, I can't say whether or not this terrible film assisted her decision in any way. In fact, it's impossible to say–however, if I were already pre-disposed to depression, and I was working on a film like this, or working ANY job that is just gut-bustingly horrible, I might be more inclined to take a few more Nembutals with my champagne dinner.
Now that I've gotten you thoroughly depressed, cheer yourself up with a visit to the good folks at the Monster Shack Reviews site. Not only do they have oldy-moldy-goldies like Octaman, they've also got modern movies, from the 2010s!
Posted in #Floridasploitation, 70s Bad!, b movies, B=Bad Movie?, cheap, Cinematic Titanic, Drugs Are Bad, Florida, Florida Film History, Florida Filmmaking, Floridasploitation, Goddammit 1970s!, Hagsploitation, If It's the Last Thing I Do!, If It's The Last Thing I Ever Do, It's MST3K's Fault!, Jabootu, March Madness & Movie Mayhem, March Madness and Mayhem Blogathon!, March Movie Madness & Mayhem, March Movie Madness!, Monster Shack Movie Reviews, Movie Blogs!, Movie Marathon, Oldsploitation, Pier Angeli, Uncategorized, Who Loves Ya 70s?, William Grefe, Z Fest!Tagged 1971, David Essex, Kerwin Matthews, Octaman, Octoman, Pier Angeli
March Movie Madness & Mayhem (Day 19?)
via AND YOU CALL YOURSELF A SCIENTIST! – Dracula Vs Frankenstein (1971)
We return to the wonderful And You Call Yourself A Scientist! to take a look at yet ANOTHER Frankenstein's Monster…Al Adamson's Dracula vs. Frankenstein. I'd bet $3 (half of the movie's budget once they finished paying the actors) that this was patched together from even more movies than Adamson admitted. Of course, it began as a biker film, just as the gloriously theme songed "The Fakers." That film had a theme song by Nelson "I worked with Sinatra" Riddle, but there was something a bit "off" about the lyrics. A little digging, and it turns out that my instinct was right–the music was Riddle's, but the oddly off lyrics were pure Adamson (he may have had some help). My point–and I do have one–is that I'm fairly certain that this type of movie (the patched together remnants of at least 3 other films) couldn't have gotten any play except in the 1970s (and earlier). Jules White did it with the Three Stooges, turning out "new" shorts in a matter of HOURS. Who'd notice that Creeps was almost exactly the same as The Ghost Talks? No one, that's who. Little attention was being paid to short subjects, and the same goes for these types of movies for the drive-in circuit. Who was really paying much attention to what was going on? You were either necking, getting high, drinking, or getting high while necking and drinking.
Anyhoo, enjoy another fine review from And You Call Yourself a Scientist!
Posted in 70s Bad!, Al Adamson, And You Call Yourself a Scientist, B Movie Graveyard, b movies, B=Bad Movie?, Drugs Are Bad, exploitation, Goddammit 1970s!, Hagsploitation, If It's the Last Thing I Do!, If It's The Last Thing I Ever Do, It's MST3K's Fault!, March Madness & Movie Mayhem, March Madness and Mayhem Blogathon!, March Movie Madness & Mayhem, March Movie Madness!, Movie Blogs!, Movie Marathon, Oldsploitation, The Last Drive In, Who Loves Ya 70s?, Z Fest!Tagged Angelo Rossitto, Anne Morell, Anthony Eisley, faded stars, Forrest J. Ackerman, Greydon Clark, J. Carroll Naish, Jim Davis, John Bloom, Lon Chaney Jr, Maria Lease, Oldsploitation, Regina Carrol, Russ Tamblyn, Zandor Vorkov
March Movie Madness & Mayhem (Day 15?)–Cult of the Damned (1969) – Journeys in Classic Film
Apparently, I've lost ANOTHER day somewhere (Day 15 is missing, just like Bunny Lake!) So, without further ado, here's what SHOULD'VE been featured…Angel, Angel Down We Go (aka Cult of the Damned). You've got Jennifer Jones, Roddy McDowall, Lou Rawls, Holly Near, and most importantly, Joe Besser in a cameo as a tour bus driver.
via Cult of the Damned (1969) – Journeys in Classic Film
Posted in 420, 70s Bad!, b movies, B=Bad Movie?, Camp, cheap, Cinematic Titanic, Cool Cinema Trash, Drugs Are Bad, exploitation, Goddammit 1970s!, guru, Hagsploitation, If It's the Last Thing I Do!, If It's The Last Thing I Ever Do, It's MST3K's Fault!, Joe Besser, March Madness & Movie Mayhem, March Madness and Mayhem Blogathon!, March Movie Madness & Mayhem, March Movie Madness!, Movie Blogs!, Movie Marathon, politics, pop music, Uncategorized, Who Loves Ya 70s?, Z Fest!Tagged Charles Manson, Cult of the Damned, Holly Near, Jennifer Jones, Joe Besser, Journeys in Classic Film, Lou Rawls, Manson Family, Roddy McDowall
March Movie Madness & Mayhem, Day 13 (Enquiring Minds Want to Know, So…)
via The Sad Tragic Fate Of Veronica Lake | National Enquirer
As you all know (all 10 of you), Flesh Feast will be the eventual first film of my b-movie blogging career…only about 2 years after I mentioned it the first time. Anywho, who better than that scandal sheet extraordinaire, the National Enquirer, to fill in the blanks about who Miss Lake was. (But for a better version, read her autobiography, Veronica. She's surprisingly candid, especially for the early 1970s!)
Posted in #Floridasploitation, 70s Bad!, And You Call Yourself a Scientist, b movies, B=Bad Movie?, Brad Grinter, Camp, cheap, Cinematic Titanic, exploitation, Florida, Florida Film History, Florida Filmmaking, Goddammit 1970s!, Hagsploitation, If It's the Last Thing I Do!, If It's The Last Thing I Ever Do, It's MST3K's Fault!, March Madness & Movie Mayhem, March Madness and Mayhem Blogathon!, March Movie Madness & Mayhem, March Movie Madness!, Movie Blogs!, Movie Marathon, Nazisploitation, RIP, Six Degrees of Stoogeration!, Uncategorized, Z Fest!Tagged Hitler in film, Hitlersploitation, Nazisploitation, scandal sheet, The National Enquirer, Veronica, Veronica Lake
March Madness & Movie Mayhem (Day 12!)
via Doris Wishman • Great Director profile • Senses of Cinema
I guess this is Day 12–did I post anything for yesterday (or Saturday? Better check that out…)
Anyhoo, here's a look at the main reason why I'm even DOING this type of thing, one Doris Wishman. Her movies aren't just movies…they're experiences. Take a good look at Deadly Weapons or Double Agent 73, her double feature starring actress Chesty Morgan. They have to be seen to be believed, and you WILL NOT get the soundtracks out of your head. Seriously, I can run through the soundtracks of both films in my head, beat for beat!
How does this relate to Six Degrees of Stoogeration? Come on–there's got to be a link somewhere! Anyhoo redux, take a look around the site, it's got plenty of great info, not just about Ms. Wishman, but much, much more!
Posted in #Floridasploitation, b movies, B=Bad Movie?, Brad Grinter, Camp, Certifiable!, cheap, Cinematic Titanic, DIY MST3K, Documentaries, Drugs Are Bad, Envisioning the American Dream, Everyone's a Critic, Expert, exploitation, Florida, Florida Film History, Florida Filmmaking, Floridasploitation, Goddammit 1970s!, Hagsploitation, If It's the Last Thing I Do!, If It's The Last Thing I Ever Do, It's MST3K's Fault!, Larry Buchanan, March Madness & Movie Mayhem, March Madness and Mayhem Blogathon!, March Movie Madness & Mayhem, March Movie Madness!, Senses of Cinema, Six Degrees of Stoogeration!, Something Awful, Thanks 1950s!, the Three Stooges, Uncategorized, Z Fest!Tagged b movies, Chesty Morgan, Doris Wishman, Exploitation Films, Floridasploitation, Hagsploitation, March Movie Madness & Mayhem, March Movie Madness and Mayhem, March Movie Madness!, Nudie Cuties, Nudist, Senses of Cinema, Sexsploitation

redpajama_set_name: RedPajamaCommonCrawl


You live in a city…but is it smart? Can it be more efficient, healthier and safer?
The answer is yes. From traffic congestion to public safety and waste management, Sylvania Connected Solutions can add 'smarts' to existing city infrastructure, to address a multitude of issues facing modern urban centres. With our multi-application network services and our portfolio of smart networks and partners – we reliably deliver digital-enabled ecosystems for thriving connected communities.
You live in a city…but can it be more efficient, safer, healthier…smarter?
Our multi-application network services have the unique ability to aggregate all of the city's devices and solutions to provide relevant, accurate and real-time intelligence, regardless of partner or technology.
Our multi-application network services has the unique ability to aggregate all of the city's devices and solutions to provide relevant, accurate and real-time intelligence, regardless of partner or technology.
As part of the City of Ryde's overall vision of adopting a 'smart cities' strategy, we were charged with upgrading the City's lighting from high wattage metal halide lighting to energy efficient, long life LED lighting. The City also wanted to have the ability to expand into other smart city applications, using a choice of vendors.
The O-Bahn City Access Project's aim was to improve travel times and reliability for users of the O-Bahn service as well as reducing traffic congestion and delays. Additional reconfiguration to deliver a shared pedestrian and cycling path with vehicle improvements. Sylvania Connected Solutions delivered a complex on-time installation of a smart lighting controls system for the Department of Planning, Transport and Infrastructure.


text:
Chlamydomonas LZTFL1 mediates phototaxis via controlling BBSome recruitment to the basal body and its reassembly at the ciliary tip
View ORCID ProfileWei-Yue Sun, View ORCID ProfileBin Xue, View ORCID ProfileYan-Xia Liu, View ORCID ProfileRui-Kai Zhang, Rong-Chao Li, View ORCID ProfileWen Xin, Mingfu Wu, and View ORCID ProfileZhen-Chuan Fan
aState Key Laboratory of Food Nutrition and Safety, Institute of Health Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, People's Republic of China;
bTransgen Biotech Co. Ltd., Beijing 100192, People's Republic of China;
cPharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204
PNAS August 31, 2021 118 (35) e2101590118; https://doi.org/10.1073/pnas.2101590118
Wei-Yue Sun
ORCID record for Wei-Yue Sun
Bin Xue
ORCID record for Bin Xue
Yan-Xia Liu
ORCID record for Yan-Xia Liu
Rui-Kai Zhang
ORCID record for Rui-Kai Zhang
Rong-Chao Li
Wen Xin
ORCID record for Wen Xin
Mingfu Wu
Zhen-Chuan Fan
ORCID record for Zhen-Chuan Fan
Edited by Randy Schekman, University of California, Berkeley, CA, and approved July 22, 2021 (received for review January 26, 2021)
Bardet–Biedl syndrome (BBS) characteristic of blindness, obesity, and kidney anomalies is a rare human ciliopathy. BBS could result from disrupted ciliary dynamics of the BBSome, a conserved octamer of BBS proteins, which facilitates intraflagellar transport with the ciliary entry and/or removal of signaling proteins. Here, we show that LZTFL1 mediates phototaxis through balancing BBSomes available for transporting into and out of cilia. LZTFL1 controls the BBSome basal body amount available for entering cilia by promoting BBS3 targeting to the basal bodies. LZTFL1 simultaneously promotes BBSome removal out of cilia by stabilizing IFT25/27, a regulator essential for BBSome reassembly at the ciliary tip. LZTFL1 applies this dual-mode system to maintain BBSome ciliary dynamics, providing a mechanistic mechanism for BBS disorder.
Many G protein–coupled receptors and other signaling proteins localize to the ciliary membrane for regulating diverse cellular processes. The BBSome composed of multiple Bardet–Biedl syndrome (BBS) proteins is an intraflagellar transport (IFT) cargo adaptor essential for sorting signaling proteins in and/or out of cilia via IFT. Leucine zipper transcription factor-like 1 (LZTFL1) protein mediates ciliary signaling by controlling BBSome ciliary content, reflecting how LZTFL1 mutations could cause BBS. However, the mechanistic mechanism underlying this process remains elusive thus far. Here, we show that LZTFL1 maintains BBSome ciliary dynamics by finely controlling BBSome recruitment to the basal body and its reassembly at the ciliary tip simultaneously in Chlamydomonas reinhardtii. LZTFL1 directs BBSome recruitment to the basal body via promoting basal body targeting of Arf-like 6 GTPase BBS3, thus deciding the BBSome amount available for loading onto anterograde IFT trains for entering cilia. Meanwhile, LZTFL1 stabilizes the IFT25/27 component of the IFT-B1 subcomplex in the cell body so as to control its presence and amount at the basal body for entering cilia. Since IFT25/27 promotes BBSome reassembly at the ciliary tip for loading onto retrograde IFT trains, LZTFL1 thus also directs BBSome removal out of cilia. Therefore, LZTFL1 dysfunction deprives the BBSome of ciliary presence and generates Chlamydomonas cells defective in phototaxis. In summary, our data propose that LZTFL1 maintains BBSome dynamics in cilia by such a dual-mode system, providing insights into how LZTFL1 mediates ciliary signaling through maintaining BBSome ciliary dynamics and the pathogenetic mechanism of the BBS disorder as well.
LZTFL1
BBSome
intraflagellar transport
phototaxis
↵1W.-Y.S., B.X., and Y.-X.L. contributed equally to this work.
↵2To whom correspondence may be addressed. Email: fanzhen{at}tust.edu.cn.
Author contributions: Z.-C.F. designed research; W.-Y.S., B.X., Y.-X.L., R.-K.Z., R.-C.L., and W.X. performed research; M.W. and Z.-C.F. analyzed data; and Z.-C.F. wrote the paper.
The authors declare no competing interest.
This article contains supporting information online at https://www.pnas.org/lookup/suppl/doi:10.1073/pnas.2101590118/-/DCSupplemental.
All study data are included in the article and/or supporting information.
Published under the PNAS license.
E. J. Michaud,
B. K. Yoder
, The primary cilium in cell signaling and cancer. Cancer Res. 66, 6463–6467 (2006).
N. F. Berbari,
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You are going to email the following Chlamydomonas LZTFL1 mediates phototaxis via controlling BBSome recruitment to the basal body and its reassembly at the ciliary tip
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Proceedings of the National Academy of Sciences Aug 2021, 118 (35) e2101590118; DOI: 10.1073/pnas.2101590118


Shhh, there's a trio of sleepy rabbits hiding inside this carrot.
Look inside this handmade, bright orange stuffed cotton carrot and you'll find a surprise inside! An easy open zipper reveals a trio of sleepy little rabbits. This perfectly portable toy is fun for kids and grown-ups. From Migration's house line. Made in small batches, so colours may vary.
For even more cute animals in pouches, check out our Monkeys in Banana and Chicken & Friends.


Member-run collective Society City is starting a monthly music series where performers will "peel back the curtain on their own creative process".
The Storyteller Sessions are co-organised with GA Gregory Productions, and will kick off with West Australian musician George Bishop plus local supports Jocean and Dyllan Floyd on April 27 from 7pm.
Tickets are $8 online, or $12 at the door at Society City - upstairs at 274 Crown Street, Wollongong. BYO drinks though vegan pizza & mulled wine available.


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LEO POSILLICO
A native of Long Island, New York, Leo, has been a successful, award-winning artist for over 45 years. His work is known and praised nationally and internationally and is widely recognizable through his signature brush stroke characters.
Trained at New York City's School of Visual Arts, Posillico, has been a photographer in Vietnam and pursued a multi-faceted art career as an art director, illustrator, board game designer, album, book cover artist, and author. He has been represented by Martin Lawrence Galleries in the United States and shown in various galleries in Japan.
"The work you are about to see is a continuation of my life as an artist, who loves the world of color and expression. I have taken a view of people and all our surroundings with a liberty of re-shaping images and places in a way that gives you an opportunity to envision my world, and engage in an experience to see something fresh and exciting."
- Leo Posillico
A West Side View
We're On Our Way
Life Of Another Great Day
Numbered and signed limited edition prints matted on white. Your choice of framed or unframed. Please contact us for more info!
Artist Working
Making A Connection
I'm Speechless
He's Learning Lines
Are These Standard Size
I've Seen This Before
Words Have a Way of Connecting Us
The Art of Speaking Out
Who's Minding the House
There's No Covering It Up
She Spoke For All Of Us
Pop Culture Art Gallery
Guerneville, CA 95446
popcultureartgallery@gmail.com
THURS - SAT: 11am - 7pm
MON-WEDS: Closed
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If you are interested in any of the pieces you see on this site, please contact us via the form below or by phone for pricing & shipping information. Thank you!
© 2019 Pop Culture Art Gallery - Created by Dani Drury


"Stiftung Warentest" – Very good! "Stiftung Warentest" – Very good! "Stiftung Warentest" is the most recognized independent German consumer magazine. The research is published in the magazine throughout Germany and other countries in the media.


Whether you are a bird watcher or a star gazer, a monocular is a handy device that you will be sure to get a lot of use out of. A cross between a telescope and binoculars, a monocular will allow you to see far away items with crystal clear precision. Like binoculars, a monocular utilizes lenses and prisms to reflect light, which allows it to magnify an image; however, like telescopes, a monocular contains a single body and viewing lens. Though the magnification levels don't compare to a top of the line telescope, a monocular is a suitable, more compact and easier to use alternative to a telescope. This device also provides better viewing capabilities than standard binoculars.
If a monocular is something that you are interested in, you are going to find that there are a lot of options to choose from when you start shopping. It's great to have a lot of options, but it can make choosing the best monocular for your needs a bit of a daunting challenge. To help you find the best monocular, we have put together this handy buyer's guide, which is full of valuable information pertaining to these useful viewing devices and will help to make the task of finding the best one for your needs a much easier task.
High powered monoculars offer exceptional magnification power. They are among the strongest monoculars produced, offering up to 12 times magnification and a 50 mm lens. With such high magnification power, you can get a clear view of an item that is as far as 1,000 feet away. High powered monoculars are ideal for hunters, bird watchers, sports enthusiasts and nature lovers.
If you want to do some high powered distance viewing under water or while you are out in the rain or snow, a waterproof monocular is an excellent option for you. Made with high quality water resistant materials, these monoculars can withstand wind, rain, sleet and snow. Do note, though, that if you plan on using it underwater, you will be limited by the depth that you can go, as the monocular can easily collapse under the strong weight of water pressure.
If you plan on looking at objects in the dark, a night vision monocular can be a handy tool. Outfitted with strong magnification and high quality infrared technology, a night vision monocular will allow you to see objects in the dark with ease. In fact, the highest quality night vision monoculars will allow you to see as clear in the dark as you can in the light, and at distances of up to 100 feet.
If you are looking for a monocular that offers a range finder, you will want to consider a tactical monocular. These devices are made to help you manually estimate the distance between you and the object that you wish to view; for example, the lens boasts silhouettes that you can use to compare to the object that you are viewing, so you can use the silhouette to determine how far away the object is that you are viewing – 300 meters or 500 meters, for example.
Compact monoculars are smaller, more compact (as the name suggests) and lighter weight, yet they still offer great viewing power. Their sleek design allows you to tuck them away and carry them around with ease; however, do note that their viewing distance is not as far as lager monoculars.
There are several factors that should be taken into consideration before you purchase a monocular. These factors are important, as they will help you choose the best viewing device to meet your specific needs.
What do you intend on using your monocular for? Will you be viewing items that are at great distances, or will you be looking at items that are within closer range? Will you be using it in various weather conditions? Do you plan on tucking it away in a compact area? You intended use is important, as it will help you choose the best type of monocular for your specific needs.
4x – 8x: These monoculars have a low magnification, which means that the image zoom is small, but the field of vision is large. Monoculars with this magnification range are good for viewing large landscapes rather than a single object.
8x – 9x: Though slightly higher, this is still considered a low range of magnification. The field of vision is still large, but the image is brighter and clearer.
10x – 14x: These monoculars offer a higher magnification level, but the field of vision becomes smaller. In other words, you will be able to see a single object with more clarity, but you will not be able to clearly see items that surround it.
20x – 25x: These monoculars offer the lowest field of view, but they offer the most powerful magnification. A monocular with this magnification level is best suited for viewing a specific item, such as an animal in a distant tree.
In addition to considering the magnification level, you should also consider the diameter of the lens. As stated above, monocular specifications are usually listed with two numbers; 8 x 28, for example. As discussed above, the 8 in this example refers to the magnification level of the monocular, while the 28 (or whatever number comes second in the specification) stands for the diameter of the lens. The lens diameter that you require will largely depend on your intended use of this viewing device. Generally, the larger the diameter, the more light will be let into the equipment. In other words, monoculars with a larger lens diameter are better suited for use in poorly lit areas. Do keep in mind, though, that the larger the lens, the larger and heavier the monocular will be.
The way you plan on carrying your monocular will impact the size and weight that is right for you. Generally, monoculars that are 8 x 25 are considered compact and will easily fit into your pocket; however, the lower the size and weight, the less viewing power you will have.
You should also consider the amount that you want to spend on the monocular. These viewing devices can vary in price. The highest quality monoculars will tend to run upwards of $100 or more. Do keep in mind that the more features the device offers and the greater the viewing power, the more expensive the monocular will likely be.
Monoculars can boast a number of features. These features are intended to improve your experience and your viewing pleasure; however, the more features a monocular offers, the more expensive it will likely be. To avoid paying for features that you are interested in or don't need, it's important to have an understanding of the different features that are available and what they can do.
The steadier you hand is while holding a monocular, the clearer your view will be. Some monoculars feature molded grips, which allow you to comfortable hold onto the viewing device and prevent slippage., which means less shaking and a clear image.
A retractable eye cup can be a handy feature, particularly if you wear glasses. With this feature, you won't have to worry about taking your glasses off to use your monocular; just adjust the eye cup as necessary and you will be able to look through the device with ease. Your glasses won't obstruct your viewing capability.
Monoculars can also come with added accessories, which are built into the price of the device and are specifically design to fit the devices they are sold with. Some of the added accessories that are available include a tripod and a carrying case. Simply set up the tripod and attach the monocular to it for easier, less shaky viewing. When the device isn't being used, you can slip your monocular into the handy carrying case, which will keep it safe and secure.
There are several manufacturers that make monoculars, which can make it difficult to find the best option for you. To help you choose the best option, we have done some extensive research and have tested out several monoculars ourselves. After our thorough assessment, we have concluded that the following monocular brands are the best of the best.
OUTERDO produces some of the highest quality monoculars that offer some of the most cutting edge designs and technologies. We particularly like their unique hand wheel bump design, which makes it much easier to hold onto their monoculars with a steady grip, thus allowing you to see images more clearly. We also like that this company offers a wide range of monoculars to suite all needs, interests and price ranges.
Polaris is a highly regarded manufacturer of outdoor equipment that is intended for use with camping, gaming and hunting. Their monoculars are top of the line and are made from the highest quality materials available. They also conduct extensive research to ensure that they are offering their customers the most innovative tools, which is something that we really found to be quite impressive.
ROXANT monoculars received great reviews online, and after testing them out ourselves, we have to say that we agree with the reviews. This company creates highly durable monoculars that are built to last and withstand tough elements. We particularly enjoyed the molded grips that the ROXANT monoculars were outfitted with, as we feel like they gave us much better control and increased our viewing abilities tremendously, as compared to other monoculars that did not feature molded hand grips.


New training courses are constantly being developed and updated on our site. If you would like be notified or have a suggestion regard new courses, complete and submit the form below.
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Detroit's Global House Star MK New Single "17" Out Today (Sept 1) On Area10/Ultra Music
Posted on September 1, 2017 by Christine Ramsey
DT: SEPTEMBER 1, 2017
FR:ALEXANDRA GREENBERG/ANDREA FAULK
DETROIT'S OWN GLOBAL HOUSE STAR MK (MARC KINCHEN)
NEW SINGLE "17" OUT TODAY (SEPTEMBER 1)
ON AREA10/ULTRA MUSIC
"17" TOUR HITS NORTH AMERICA THIS FALL
Today, September 1 celebrates the release of MK's new single "17," a song that feels like it's destined to become a valuable gem in his already solid repertoire. Based on the overwhelming positive response thus far, "17" is set to weave its way onto radio playlists, streaming sites and club dance floors everywhere. It is available now on Area10/Ultra Music and features the producer's trademark piano chords alongside a constant and powerful bass line that gives the track a modern but classic house vibe. Like Katy Perry's "Teenage Dream," it evokes teenage nostalgia with lyrics that hark back to days when "…I got your back like we're still 17."
Check out "17" now here: http://smarturl.it/MK17
Lyric video for "17": http://smarturl.it/MK17yt
"17" lyric video
To support the song's release, MK will embark on the 17 Tour this fall. It kicks off October 26 in Santa Barbara, CA and will touch down in most major North American markets including San Francisco, Los Angeles, New York, Boston, Chicago, Toronto, Detroit, Dallas and more. All dates follow below and tickets are on sale now at: http://marckinchen.com/tour/.
The release of "17" closes out an incredible summer touring season for MK (Marc Kinchen) that featured shows in the States like EDC in Vegas, main stage at HARD Summer in early August and still to come an appearance on mainstage at the Imagine Festival in Atlanta as well. Add all this to his in-demand remixes for the artists such as Rihanna, London Grammar, Solardo and Clean Bandit, along with his original productions, MK has swiftly become one of the world's most in-demand producers in dance music. Several of his earlier releases including "Always""Burning" and "Push The Feeling On" were instrumental in first helping dance music cross over into the mainstream. His 2014 remix of Wankelmut & Emma Louise's "My Head Is A Jungle" has amassed over 45 million Spotify streams. Prior to 17, his recent releases include"My Love 4 U" (feat A*M*E), MK's the 2016 hit and "Piece of Me" (feat. Becky Hill) became a summer anthem, garnering just under 40 million Spotify plays in the process.
Catch MK on the 17 Tour this fall:
10/26 Santa Barbara, CA EOS Lounge
10/27 San Francisco, CA Audio
10/28 Los Angeles, CA Minimal Effort
11/02 Brooklyn, NY Output
11/03 Boston, MA Bijou
11/04 Toronto, ON Noir
11/11 Washington, D.C. U Street Music Hall
11/16 Austin, TX Kingdom
11/17 Miami, FL Trade
11/18 Dallas, TX It'll Do
11/24 San Diego, CA SPIN
11/25 Denver, CO Vinyl
12/01 Philadelphia, PA Rumor
12/02 Detroit, MI Magic Stick
For more information on MK, please visit
Facebook I Twitter I Soundcloud
For more information on MK, contact:
Alexandra Greenberg agreenberg@msopr.com
Andrea Faulk (tour) afaulk@msopr.com
This entry was posted in MK, Press Releases. Bookmark the permalink.


PROVIDENCE, R.I. – Some Rhode Island residents say they never received a warning about military training exercises last week that included helicopters buzzing over the treetops and simulated explosions.
Army representatives referred comment Tuesday to the Rhode Island National Guard, which says it tried to help alert residents of a Providence neighborhood before the Friday night exercise.
A National Guard spokesman says the Army wanted an urban environment to practice special operations tactics.
The Army sent a release on June 4 saying there would be a week of training throughout the state and nearby residents would receive more specifics.
An automated message was sent to nearby cellphones shortly before the exercise.
The spokesman says police and Army personnel also went door to door near the training site, but notifying everyone was impossible.


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text:
Frank Monaco è nato a New York il 27 dicembre del 1917 da una famiglia di emigrati molisani di Cantalupo nel Sannio (IS). Ha partecipato alla seconda guerra mondiale nelle file dell'esercito americano, fino al congedo dovuto ad una ferita alla mano destra. Dopo un periodo di studi di arte e giornalismo presso la New York University si dedica alla fotografia. Arriva a Roma nel 1950 e durante alcune visite in Molise ai parenti materni scatta alcune foto di contadini molisani che poi fa vedere casualmente al pittore Afro, di cui era diventato amico. Queste foto sono oggi una delle più importanti testimonianze antropologiche della società contadina molisana e meridionale agli inizi degli anni '50. Nel 1955 si sposta a Londra dove avvierà poco dopo la collaborazione con la rivesta cattolica 'Jubelee'. Si lega all'agenzia 'Rex Features' che dai primi anni '60 gestisce il suo portafoglio di immagini. Una selezione delle foto di Frank Monaco è nella collezione permanente del Victoria & Albert Museum di Londra. Ha fornito immagini per il libro 'The Irish' di Tom O'Hanlon e pubblicato The Dwell in Monasteries (1982), The Women of Molise - An italian Village 1950 (2000), Brother and Sistes (2001). Si è dedicato inoltre a temi di natura sociale e religiosa ed alla conoscenza della società indiana. Le sue foto sono state pubblicate in ogni parte del mondo da oltre 450 tra libri e giornali. La sua opera è stata presentata in mostre realizzate negli USA, Inghilterra, Estonia, India e altri paesi. L'Amministrazione Comunale di Cantalupo nel Sannio ha dedicato all'illustre fotografo una mostra il 24 luglio del 2005 allestita con molti dei suoi scatti realizzati nel paese nel 1950.
Frank Monaco muore a Londra il 26 giugno del 2007 ad 89 anni.

redpajama_set_name: RedPajamaWikipedia


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Q: How to auto-match via GKTurnBasedMatch I'm trying to implement a turn-based GameKit game using a custom user interface. Specifically, I'm trying to create a new match with auto-matched players.
I've scoured the docs, but the only information I see is ambiguous at best.
It looks to me like the recipients property of GKMatchRequest determines whether or not auto-matching is used when the object is passed to the relevant method. Here's what the docs say about recipients:

If this property is non-nil, GameKit invites the specified players. GameKit doesn't use automatch to fill player slots, and ignores the maxPlayers and minPlayers properties. If this property is nil, GameKit doesn't invite any players. The default value is nil.

How can it be that setting this property to non-nil invites the specified player(s), but setting it to nil "doesn't invite any players"? It sounds to me like the only options are 1) invite specific player(s), or 2) create a match without an opponent.
I must be missing something, because this doesn't make sense.
Question: How does one go about creating a GameKit match with auto-matched players without using the default Game Center interface?
Here's what I've tried (opponent is a GKPlayer):
let theRequest = GKMatchRequest()
theRequest.minPlayers = 2
theRequest.maxPlayers = 2
theRequest.defaultNumberOfPlayers = 2
theRequest.inviteMessage = "Let's play!"
theRequest.recipients = [opponent]
theRequest.recipientResponseHandler = { playerWhoReceivedInvitation, responseToInvitation in
   //Do stuff
}

GKTurnBasedMatch.find(for: theRequest) { match, error in
   //Do stuff
}

A: when you build your request, you can differentiate between matching with a specific player vs auto-matching. if you specify theRequest.recipients = [opponent] it's the former.
match with specific player
//configure a GKMatchRequest for specific player(s)
request.recipients = [opponent]
request.inviteMessage = "Do you want to play a game?" //optional. affects the push notification

automatch with anyone
for automatching, don't set recipients but set the player numbers instead
//configure a GKMatchRequest for automatching
request.minPlayers = 2 //set number of players
request.maxPlayers = 2

/*
optional -- set mask for automatching only as a specific role.
for example if you have a chess game and you want to auto-match
but only play black or only play white.
*/
request.playerAttributes = 0xFFFF0000 //mask for "i want to match as role A (black)"
request.playerAttributes = 0x0000FFFF //mask for "i want to match as role B (white)"
request.playerAttributes = 0xFFFFFFFF //mask for "i'll match with either" -- this is the default

redpajama_set_name: RedPajamaStackExchange


"Verifying credentials is in progress"
Historically SecureAuth provided a fingerprinting app (not the Authenticate app) that users could install on their smartphone, the sole purpose of which was to respond to the custom URL scheme of secureauth:/ and return a fingerprint back to the realm. However that app is no longer available and is not recommended for use either.
Current best practise is to use Cookie mode instead of App mode.


Optometrists share how MacuLogix® helped integrate the AdaptDx® into their eye care practice.
Dr. Lowe: MacuLogix team really helped with our practice integration by really educating my staff to the highest level they could, making sure they knew why the technology was important to our practice, and what patient would be a patient that would need the testing, how to tease that out so that my staff would know how to educate our patients and give the test in a more efficient manner.
Dr. Martin: In terms of integrating it in our practice we had, obviously, the nuts and bolts stuff you'd expect with just installation and what not. They stayed with us every step of the way. They've never told me, "no." If I've called them and said, "Hey I need four more posters to put up in my office because I've got a place I have people parked for 10 minutes and I want them thinking about this." They just do it. They've been fantastic and I think they get it and I think they get that, you know, this is an opportunity to completely change the face of the way we manage the disease. and, you know, no request has been too small.
Dr. Morrow: Our trainer was awesome and stayed long enough to make sure everything was there; stayed long enough to make sure everything was training perfectly.
Dr. Lowe: The way I have integrated dark adaptation testing into our workflow is really by identifying patients that are at risk and for my practice that means discussing the technology with them, educating about them about the importance of it, and then reappointing my patients for a specific time that I can run the test and be able to talk to them about the results.


TODAY WAS A GREAT DAY AT LAKE IDA WITH THE MEDICI FAMILY. THE FIRST HOUR WAS A LITTLE SLOW, BUT AS TIME WENT ON IT GOT MUCH BETTER. WE FISH ONLY A 4 HOURS OR WHAT WE CALL IN THE INDUSTRY A HALF DAY TRIP. WE CAUGHT 16 PEACOCK BASS, IN THERE VIEW AND MY THAT MADE A GOOD DAY OF BASS FISHING. THE ARTIFICIAL BITE WAS RED HOT MOST OF THE DAY, ALTHOUGH THE SHINNER BITE WAS A LITTLE SLOW TODAY. THE LIVE BAIT BITE DID PICK UP AND PRODUCED THE BIGGER PEACOCK BASS TODAY. I AM LOOKING FORWARD TO SEEING THE MEDICI FAMILY AGAIN IN JULY FOR ANOTHER GOOD DAY OF FISHING IN THE EVERGLADES.


text:
Author: thegrassrootstourist
Fulham U23
Friday 22nd February 2019, 1400 KO Fulham FC U23 vs Reading FC U23 Sadly work commitments have put paid to any football watching in recent weeks, but after over a month with no football, I got back on the horse at Motspur Park, where Fulham's second string faced off against Reading's, in the Premier League... Continue Reading →
Saturday 19th January 2019, 1500 KO Frome Town FC vs Metropolitan Police FC The Build Up A Step Three match-up in the Evo Stik Southern League Premier Division South was my destination this weekend, and it was a fairly unique journey there for me. With plans in Wiltshire for the evening, and my other half... Continue Reading →
Worthing FC
Saturday 12th January 2019, 1500 KO Worthing FC vs Lewes FC The Build Up On Saturday morning I, along with numerous Brighton-bound Liverpool fans, boarded the train from Clapham Junction to Littlehampton and Eastbourne and made my way to the Sussex coast. My destination wasn't the Amex though, but a few miles west along the... Continue Reading →
Wednesday 9th January 2019, 1945 KO Woking FC vs Welling United FC The Build Up After a proud performance in the FA Cup Third Round loss to Watford at the weekend, Woking were back in action at Kingfield in the comparatively mundane matter of fighting for a title in the Vanarama National League South on... Continue Reading →
Elburton Villa FC
Saturday 29th December 2018, 1500 Kick Off Elburton Villa FC vs AFC St Austell The Build Up Weighing approximately 3kg more than when I last (pre-Christmas) delivered a blog entry, I visited Plainmoor on Boxing Day to take in Torquay United vs Truro City. However, having left my camera at home when I drove down... Continue Reading →
Wingate & Finchley FC
Tuesday 18th December 2018, 1945 Kick Off Wingate & Finchley FC vs Bishop's Stortford FC The Build Up My last venture into the Alan Turvey Trophy (Velocity Trophy for sponsorship purposes) was a September trip to Leatherhead, to see them dispatched at the first hurdle by a David Ajiboye goal for Worthing. Back then, anything... Continue Reading →
Fulham U18 vs Chelsea U18
Saturday 24th November 2018, 1100 Kick Off Fulham FC U18 vs Chelsea FC U18 Nestled snugly in the Borough of Kingston-upon-Thames, is the leafy suburb of Motspur Park, and around 500 metres from it's eponymous train station, is the training ground of Premier League Fulham. A large manor-type property, the actual HQ building is surrounded... Continue Reading →
Hampton & Richmond Borough FC
Monday 12th November 2018, 1945 Kick Off Hampton & Richmond Borough FC vs Oldham Athletic AFC The Build Up Televised football is a paradoxical thing for a match-attending football fan. On the one hand, matches are played on more days to squeeze in as much glorious cash-generating TV as possible, which means you can get... Continue Reading →
Metropolitan Police FC
Saturday 10th November 2018, 1500 Kick Off Metropolitan Police FC vs Newport County AFC The Build Up The excitement around the non-league community reached fever pitch a few short weeks ago, as after months of campaigning, the draw for the First Round Proper of the FA Cup was made on live television at the Hertfordshire... Continue Reading →


text:
Q: Need to match two groups in Sed expression This is similar to Using sed to replace beginning of line when match found but a different question so hence this thread.
I wish to uncommented out commented out code. More specially, all cases where the variable myVar is commented out.
Example:
public class MyClass {
   ...
   ...
   //myVar.setAge(200);
   //myVar.setPlanet("mars");
}

to
public class MyClass {
   ...
   ...
   myVar.setAge(200);
   myVar.setPlanet("mars");
}

The regex:
^\\.*myVar.*$

Gets me everything I need.
The tricky part is getting the correct Sed. I try:
sed 's/(^\\)(.*myVar.*$)/\2/g' Build_DM_Digests_Batch.cls

On the following basis. Create two match groups. The first one is the commented out lines. And the second is the rest of line. Replace the entire line with just the second mateched group.
This gives error:
sed: -e expression #1, char 29: Unmatched ) or \)

Any tips?

A: Use sed 's/^\( *\)\/\/\(.*myVar.*$\)/\1\2/' file
$ cat hw.java
class hw {
    public static void main(String[] args) {
        System.out.println("Hello World!");
//        myVar=1
        //myVar.setAge(200);
        //myVar.setPlanet("mars");
    }
}

$ sed 's/^\( *\)\/\/\(.*myVar.*$\)/\1\2/' hw.java
class hw {
    public static void main(String[] args) {
        System.out.println("Hello World!");
        myVar=1
        myVar.setAge(200);
        myVar.setPlanet("mars");
    }
}

Use the -i option to save the changes in the file sed -i 's/^\( *\)\/\/\(.*myVar.*$\)/\1/' file:
Explanation:
^      # Matches the start of the line
\(     # Start first capture group
 *     # Matches zero or more spaces
\)     # End first capture group
\/\/   # Matches two forward slashes (escaped)
\(     # Start second capture group
.*     # Matches anything
myVar  # Matches the literal word
.*     # Matches anything
$      # Matches the end of the line
\)     # End second capture group

Here we capture the whitespace upto the // and then everything after if myVar on the line and replace with \1\2.
Your logic is almost there but a couple of things, firstly escaped all brackets and secondly you want ^( *)\/\/ not ^\\ that is two escaped forwardslashes with the whitespace captured not two backslashes at the start of the line:
If you don't want to escape brackets you need to use the extended regexp flag of sed which is -r for GNU sed on OSX it's -E so check with sed --help.
sed -r 's/^( *)\/\/(.*myVar.*$)/\1\2/' file

Note: when you are matching the whole line (from ^ to $) the g flag is redundant.

A: Another way:
sed 's!^\([ \t]*\)//\(.*\<myVar\>\)!\1\2!' input

A: Chris' answer and explanation are valid. However, I would like to add a much cleaner equivalent expression. This expression relies on two changes

*

*Changing the separator to any character not included in the regexp, eg |, gets rid of the escape characters for /

*Specifying an extended regular expression (-r) gets rid of the escapes for parentheses ()
This results in a readable command which is clearer in its intent and closer to what you would have expected to use.
sed -r 's|^( *)//(.*myVar.*$)|\1\2|' filename


Marion "Connie" Messina, age 83, of Stoneham, formerly of Somerville died Thursday, February 21 at the Bear Hill Nursing Home. Born in Boston on February 13, 1936 she was the daughter of the late Joseph and Della (Conway) McAfee. Mrs.
Hughia Claudette Magnus (Anderson), age 69, passed away on Wednesday, February 20, 2019 in Atlanta, Georgia. Born July 17, 1949 in Washington, D. C….


Please note that there is a $25 fee that covers the reading, invoice and account changes.
We may need to contact you about this special reading.
I am the account holder or I have been authorised by the account holder to request a special meter reading with the details above, and I accept the Watercare general terms and conditions for this service.


10th August 2015, Colombo; The National Mobile Service Provider Mobitel received the prestigious accolade for culture and heritage category at the recent mBillionth Awards held at the India Habitat Centre, New Delhi, India for Mobitel mGuide, the innovative mobile-based audio service that provides ample information of archaeological and historical interest with just a press of a button from a Mobitel connection.
The industry‐driven mBillionth Awards gives recognition to organisations in the South Asian region, that take the initiative to bridge the digital divide, empower people and bring about greater socio-economic equality. Mobitel gained much recognition for mGuide, a virtual tour guide that provides information about archaeological, historical and cultural interests and places of historical importance in Sri Lanka.
Launched in 2011 for the first time in Sri Lanka, mGuide provides information through a voice short code by simply dialing 888 on a phone with Mobitel connectivity. This service is enabled in collaboration with the Department of Archaeology - Sri Lanka and offers access to information on historic sites in the country which are of archaeological or tourist interest. The service is currently available in Sinhala, Tamil and English and will be available in 10 other languages in the near future including Hindi, French, German, Japanese, Chinese, Korean and Arabic to cater to the growing tourism sector.
The mBillionth Awards acknowledges South Asia as a key hub of the world's mobile and telecommunications market in terms of penetration and innovation. The Awards recognise mobile phones as the most powerful digital tool for empowerment across the world, surpassing all other media forms such TV, radio, Internet, newspapers, magazines and landlines. With the rapid increase in penetration of mobile technology across almost all socio-economic strata around the world mBillionth Awards identifies the mobile platform as the natural choice for overcoming the information barrier and extending essential and innovative digital services to the broadest section of the population.
Caption: Award being received by Madura Hewage of Mobitel from Dr. Lalit K. Panwar Secretary Tourism, Government of India.


text:
Combination Nivolumab and Ipilimumab Shows Efficacy in Advanced Melanoma
Georgina V. Long, BSc, PhD, MBBS, FRACP
Georgina V. Long, BSc, PhD, MBBS, FRACP, discusses the design and efficacy of the phase III CheckMate 067 trial for patients with advanced melanoma.<br />
Georgina V. Long, BSc, PhD, MBBS, FRACP, co-medical director of Melanoma Institute Australia (MIA), chair of Melanoma Medical Oncology and Translational Research at MIA and Royal North Shore Hospital, University of Sydney, discusses the design and efficacy of the phase III CheckMate 067 trial for patients with advanced melanoma.
This was a 3-arm randomized trial which investigated ipilimumab (Yervoy), an anti-CTLA4 therapy, and nivolumab (Opdivo), an anti-PD-1 therapy, in combination versus ipilimumab alone versus nivolumab alone. Long says the combination of nivolumab and ipilimumab was not originally powered to be compared to the nivolumab monotherapy, but descriptive analyses have been completed. These data looked at the 5-year overall survival (OS) for patients with advanced melanoma on these regimens.
The descriptive analysis showed that the landmark OS at 5 years was high, according to Long. She explains that survival remained the highest with the combination of nivolumab and ipilimumab at about 52%, whereas with nivolumab alone, it was about 44% and with ipilimumab, it was the lowest, at about 26%.
<< View more resources and information regarding melanoma


text:
Download Zipped Introduced WP 6.1 HB0055.ZIP 6,916 Bytes
[Status][Bill Documents][Fiscal Note][Bills Directory]
1 TOWN OPTION SALES AND USE TAX
4 Sponsor: Peter C. Knudson
5 John L. Valentine
6 AN ACT RELATING TO THE SALES AND USE TAX ACT; AUTHORIZING A TOWN
7 OPTION SALES AND USE TAX FOR TOWNS THAT IMPOSED A LICENSE FEE OR
8 TAX ON BUSINESSES BASED ON GROSS RECEIPTS ON OR BEFORE JANUARY 1,
9 1996; AND PROVIDING FOR RETROSPECTIVE OPERATION.
10 This act affects sections of Utah Code Annotated 1953 as follows:
12 59-12-1301, Utah Code Annotated 1953
15 Section 1. Section 59-12-1301 is enacted to read:
16 Part 13. Town Option Sales and Use Tax Act
17 59-12-1301. Title.
18 This part is known as the "Town Option Sales and Use Tax Act."
20 59-12-1302. Authority to impose -- Base -- Rate.
21 (1) Beginning on or after January 1, 1998, the governing body of a town may impose a tax
22 as provided in this part in an amount that does not exceed 1%.
23 (2) A town may impose a tax as provided in this part if the town imposed a license fee or
24 tax on businesses based on gross receipts under Section 10-1-203 on or before January 1, 1996.
25 (3) A town imposing a tax under this section shall:
26 (a) adopt an ordinance:
27 (i) imposing the tax on the sales and uses described in Section 59-12-103;
1 (ii) exempting from the tax the sales and uses described in Section 59-12-104; and
2 (iii) providing an effective date for the tax;
3 (b) impose the tax on the first day of a calendar quarter; and
4 (c) notify the commission at least 30 days before the day on which the commission is
5 required to collect the tax.
6 (4) The commission shall:
7 (a) except as provided in Subsection (4)(c), distribute the revenues generated by the tax
8 under this section to the town imposing the tax;
9 (b) administer, collect, and enforce the tax authorized under this section pursuant to:
10 (i) the same procedures used to administer, collect, and enforce the sales and use tax under
11 Title 59, Chapter 12, Part 1, Tax Collection; and
12 (ii) Title 59, Chapter 1, General Taxation Policies; and
13 (c) deduct from the distribution under Subsection (4)(a) an administrative charge for
14 collecting the tax as provided in Section 59-12-206.
15 Section 3. Retrospective operation.
16 This act has retrospective operation to January 1, 1998.
Legislative Review Note
as of 1-8-98 2:03 PM
A limited legal review of this bill raises no obvious constitutional or statutory concerns.
Office of Legislative Research and General Counsel
[Bill Documents][Bills Directory]


How many EX/Lv. X cards are you aloud to have in a deck?
Is there a limit to how many of those cards you can have?
>Pokémon LV.X cards also share the same name as the Pokémon they Level-Up from, and as such only four of either card are allowed in a 40- or 60-card deck. For instance, a player would be allowed to have two Honchkrow LV.42 and two Honchkrow LV.X in the same deck, but only four Honchkrow would be allowed in total. As well as that, because of the fact that these two cards share the same name, an effect which would remove the highest Stage Evolution card from a Pokémon would, in this example, force the removal of both Honchkrow cards, leaving only Murkrow.
It's limited by the name. If you have 3 Mews and a Mew LVX, no more Mews are allowed. That's all.
That's does not apply to pokemon EX (It does with X). you can have 4 shaymin and 4 shaymin EX in the same deck.
About how many Energies, Trainer and Pokemon cards should there be in a good deck?
What happens if you run out of cards on your deck in TCG?


text:
Use Of Bots Has Increased Fake Account Creations
The ThreatMetrix Cybercrime Report 2017 is out, and is a troubling read for anyone who has anything to do with data security. As a fraud prevention company protecting nearly a billion and a half users around the world, they're uniquely positioned to know, and their insights on the threat landscape is invaluable.
Their main finding is that hackers, scammers and fraudsters are moving away from using stolen debit and credit cards, given that these things have such a short shelf life. On the face of it, that sounds like it might be a good thing, until you understand what they're doing instead.
They're making use of stolen identity data to create bogus accounts, then applying for lines of credit on their own. Even worse, they're taking full advantage of automation to speed the process along. According to the report, the volume of global fraud attacks is up a mind blowing 100 percent in just two years, with 700 million incidents reported in 2017 alone.
Bots are coming to play an increasingly important role in the activity of the fraudsters, too. Once a new, fraudulent account has been created, it's handed off to a bot to test it and make sure it's valid, which increases its value on the Dark Web.
How big of a problem are bots on the web these days?
According to the report, ThreatMetrix blocked 1.5 billion bot attacks last year, with some retailers reporting that more than 90% of their daily traffic is comprised of bots.
At the root, what's driving this behavior are the increasingly common, large-scale data breaches that put up to hundreds of millions of data records into the hands of fraudsters. Until and unless the flow of data can be stopped, we can expect this type of activity to continue to increase.
No matter how you slice it, 2018 is going to be a very interesting and very busy year.
Apple And Google No Longer World's Top Brands
New Google Chrome Feature Created For Better Password Security
Windows 10 Will Get Android Phone Call Integration Features
40 Percent Of All Login Attempts Are From Bots
Google Is Bringing Back Chrome's Close Other Tabs Option
New Ransomware Threatens To Release Stolen Data To Public
New Icons Coming To Microsoft Windows 10


Pacifica Ultra CC Cream Radiant Foundation SPF17 Instantly illuminate and perfect your skin with specially adapted colour correcting minerals and multi-action natural beneficials including coconut water. Get the radiant skin you have always dreamed of having. A radiant foundation with 100% physical SPF protection plus moisturising skincare. Vegan.
Instantly illuminate and perfect your skin with specially adapted colour correcting minerals and multi-action natural beneficials including coconut water. Get the radiant skin you have always dreamed of having. A radiant foundation with 100% physical SPF protection plus moisturising skincare. Bring back radiance and a youthful glow instantly.
100% physical broad spectrum SPF17 to protect your skin from the sun's harmful UVA/UVB Instantly illuminates and perfects skin. Contains a blend of natural beneficials to provide anti-ageing benefits and subtle Jasmine fragrance. Specially adapted colour correcting minerals adapt to your own skin tone 100% recyclable airless container.
Every once in a while you want a little more coverage for your skin. This Pacifica Ultra CC Cream is a natural version of a multi-tasking moisturiser + foundation alternative fortified with 100% physical SPF facial sunscreen protection. The skin you have always dreamed of having – radiant, dewy, illuminated.
Contains absolutely no animal ingredients (including carmine, beeswax and lanolin), NO animal testing. No FD&C colours, mineral oil, parabens, phthalates, petroleum, propylene glycol, SLS, gluten, peanut oil and other ingredients you don't want on your skin.
Apply Pacifica Ultra CC Cream SPF15 to clean skin with fingers, brush or sponge. Blend well in an upward circular motion onto face and neck for smooth, even coverage.
INACTIVE INGREDIENTS: water (aqua), caprylic/capric triglyceride, sorbitan sesquioleate, dimethicone, potassium cetyl phosphate, glycerin, silica, jojoba esters, cetearyl olivate, sorbitan olivate, mica, citric acid, potassium sorbate, sodium dehydroacetate, sodium benzoate, fragrance (all natural), sodium hyaluronate, cocos nucifera (coconut) water, withania somnifera root extract, carthamus tinctorius (safflower) seed oil, macrocystis pyrifera extract, linalool, amyl cinnamal, titanium Dioxide CI 77891, Iron oxides CI 77491, CI 77492, and CI 77499. ACTIVE INGREDIANT: Zinc Oxide.
Moderate coverage, nice glow, beautiful application. I'd been using another brand of tinted moisturizer/CC cream for years until I found out they have a horrible toxicity rating in the EWG makeup database. I've been on the hunt for a substitute and although I found other decent BB/CC creams, none really impressed me or matched my skin tone. I thought I'd try this on a whim and I had low expectations. Not only was it a PERFECT match for my medium skin tone (I'm half Indian, half Caucasian), it provides medium coverage (not too heavy, not too light), gives me a nice glow, lasts all day long, is super easy to wash off AND is free of parabens and other naughty, toxic ingredients. It smells pleasant, too, and the pump dispenser keeps things mess-free. I love this stuff and hope it never goes out of production!


It's really kind of sad how often new buildings are a lot more interesting under construction than they are when completed.
Such would seem to be the case with Solomon Cordwell Buenz's new Loews Chicago Hotel tower on Park Drive just south of the Sheraton in Streeterville, scheduled to open next January. If you look at it from just the right angle, it can almost appear arresting . . .
. . . but from Michigan Avenue and along the river it's a rather dull stick, dependent on the sun's sparkle to mask its utilitarian sameness. If you look closely, you can see the thin vertical incision that's the new design cliche for breaking up the stolidity of a tall curtain wall.
What read, in earlier renderings, as a matching vertical incision at the top, now looks to be a large raised box where Loews will spell out its name in really big letters . . .
There's also, until such time as the rest of the site is developed, a massive blank garage wall to the north . . .
Oh well, it was fun while it lasted, and we'll always have 2012, when the construction site, with clear viewing platforms from the raised sidewalks all around it, was one of the best nocturnal shows in the city.
No, you aren't boring your readers.


text:
About IABC
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Announcement of the appointment of Ms Penny Williams PSM as Australia's Ambassador to Indonesia
Home : : Announcement of the appointment of Ms Penny Williams PSM as Australia's Ambassador to Indonesia
By admin 2021-04-19 17:03:42 0
foreignminister.gov.au
Today I announce the appointment of Ms Penny Williams PSM as Australia's Ambassador to Indonesia.
Australia's relationship with Indonesia is one of our most important partnerships. It is underpinned by the Morrison Government's 2018 Comprehensive Strategic Partnership which frames our extensive cooperation spanning strategic, security, economic and people-to-people ties. Together we contribute to regional and global forums, manage one of the longest maritime boundaries in the world, and combat terrorism and transnational crime. We are working in partnership to respond to and recover from the COVID-19 global pandemic.
Australia's total two-way goods and services trade with Indonesia was worth $17.7 billion in 2019, making Indonesia our 13th largest trade partner. The entry into force of IA-CEPA in 2020 was an important milestone in the partnership and will create stronger economic ties and provide greater certainty and improved access for our two countries' exporters, service providers and investors.
Australia and Indonesia are working closely together to respond to the shared health, humanitarian and economic challenges posed by COVID-19. Indonesia is an important partner of our development program and Indo-Pacific Vaccines Initiative, through which we are supporting access to safe and effective COVID-19 vaccines.
Ms Williams is a senior career officer with the Department of Foreign Affairs and Trade (DFAT) and was recently Deputy Secretary in the Department. She has previously served overseas as High Commissioner to Malaysia and was Australia's first Ambassador for Women and Girls. Ms Williams is Australia's first female Ambassador to Indonesia.
Ms Williams is fluent in Indonesian and holds a Bachelor of Asian Studies (Honours) focused on Indonesia; and a Masters of Applied Anthropology and Participatory Development.
I thank outgoing Ambassador Gary Quinlan AO for his contributions to advancing Australia's interests in Indonesia since 2018.
Read original
Announcement of the appointment of Ms Penny Williams PSM as Australia's Ambassador to Indonesia 2021-04-19 17:03:42
Central Queensland University (CQU) Opens Jakarta Campus 2021-04-19 16:39:13
Aspen Medical, Docta ink $1.3bn Indonesia healthcare deal 2021-04-19 16:31:11
The Indonesia Australia Business Council (IABC)
World Trade Center I, 16th Floor
Jl. Jend. Sudirman Kav. 29-31
WA: +62 811 9698 191
Copyright The Indonesia Australia Business Council (IABC) ©


This study aims at realizing 3D smooth dynamic quadruped locomotion in a robot. The smooth 3D dynamic walking can be realized by using the information of the posture angle and force, and moreover by considering the robot dynamics. In this study, a hierarchical control in which many sensor informations are utilized is proposed, and is confirmed by experiments using a quadruped robot.
1. A trot gait in which a diagonal pair (e. g. right foreleg and left rearleg) forms the supporting legs and there is a short period of three-legs-support phase , was treated. For the high speed locomotion, it is desirable that the ratio of the two-legs-support phase is large. However, the robot system in this phase shows the unstable behavior about the diagonal line which is passing through the two supporting point. In this phase, a low order model which we have been proposed was utilized in the upper level of the hierarchical control structure.
2. A walking simulator of the quadruped robot system was developed. The suitable compliance for each walking phase was designed by using this simulator.
3. The foot pressure sensor and the joint torque sensor were developed which were installed in the robot system. The proposed copliance control is realized by using these sensor informations. During the three-legs-support phase, the slippage of the tiptoe often happens if high gain position feedback is applied at all joints. Therefore, the compliance control was applied to this phase. The walking experiments with walking speed of 0.6m/s were conducted by using the above method.
4. The change of the walking direction during the dynamic walking can be realized experimentally.


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Q: Proguard Error : Execution failed for task ':app:transformClassesAndResourcesWithProguardForDebug' I am trying to build app using ProGuard in Android Studio 2.2.3 but I am getting below error :
Error:Execution failed for task ':app:transformClassesAndResourcesWithProguardForDebug'.
> Job failed, see logs for details

A: Do you have a proguard-project.txt file in your project?
If so can you post its content? Also, you can try running 'gradle --stacktrace assemble --debug' for more details about your error.


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Computer Program Finds New Applications for Old Medications
The program, DrugPredict, searches through hundreds of thousands of chemical combinations and pairs them with diseases they might be able to fight.
Non-steroidal anti-inflammatory drugs (NSAIDs) are neither new nor novel, but that doesn't mean science has already found every way that they can benefit patients. A computer program developed at Case Western Reserve University, called DrugPredict, that can look for new uses for old drugs.
The program's creators recently teamed up with oncological researchers to apply laboratory scrutiny to DrugPredict's predictive prowess. In a newly-published study, they demonstrate how the program may have correctly determined the usefulness of NSAIDs in the fight against epithelial ovarian cancer.
The platform works by searching through thousands of FDA-approved drugs, looking at their chemical compounds, phenotypes, and genetic factors to pair them with diseases where they may be applicable. Because drug discovery is typically a long and expensive process, tools like DrugPredict could be useful in leveraging medicines that have already been found safe.
"For any given disease, DrugPredict simultaneously performs both a target-based, and phenotypic screening of over half a million chemicals, all in just a few minutes," Rong Xu, PhD, said. Xu, one of the program's co-developers, is an associate professor of biomedical informatics in the department of population and quantitative health sciences at Case Western Reserve University School of Medicine.
For this study, the program crunched out a list of nearly 7,000 chemicals that showed promise for treating epithelial ovarian cancer. Over 1,000 FDA-approved drugs appeared on the list. Other than 15 existing cancer treatments that appeared at the top, NSAIDs consistently outranked every other class of FDA-approved drugs that DrugPredict recommended.
Laboratory testing showed that one NSAID, indomethacin, may be particularly effective. Their work found that the drug "inhibits cell proliferation, cell survival and induces robust cell death in cisplatin-resistant cells and [tumor-initiating cells]." Cisplatin is a commonly-used chemotherapy drug, and the researchers suggest their lab results showed that indomethacin may be an effective adjuvant to the therapy.
By combining DrugPredict with laboratory expertise, "We were able to uncover a potentially novel drug approach to treat ovarian cancer," Analisa DiFeo, PhD, of the Case Comprehensive Cancer Center at Case Western Reserve University School of Medicine said. "Our results provide a rationale to test NSAIDs like Indomethacin as a novel drug in ovarian cancer clinical trials."
According to the statement, DiFeo will do just that: she is currently planning a phase 1 clinical trial to test indomethacin's ability to target ovarian cancer stem cells in patient tumors.
The study, "Using a novel computational drug-repositioning approach (DrugPredict) to rapidly identify potent drug candidates for cancer treatment," was published recently in Nature Oncogene.


TULSA, Okla. (April 5, 2019) – Every major league sport has one season-ending event that stands for its very highest level of achievement.
professional bass fishing world since its January debut, and the league announced today that the season-ending championship for the tour will be titled "Redcrest".
La Crosse, Wisconsin, will serve as host to the first Redcrest event, which will be held August 19-25, 2019.
The competition will take place in the bass-rich waters of the Upper Mississippi River and feature the top 30 anglers who have accumulated the most qualifying points over the course of the 2019 Bass Pro Tour's eight-event season.
Along with the competition days, Redcrest will also feature a community expo with Bass Pro Tour sponsors, Friday to Sunday, August 23-25. All activities, including interaction with the pros, are free and open to the public.
MLF Pro Edwin Evers leads in Bass Pro Tour points after three events. The MLF Redcrest championship event will feature the 30 anglers who have accumulated the most qualifying points over the course of the 2019 Bass Pro Tour's eight-event season.
Rucks also provided origin of the Redcrest name, explaining that the prominent red MLF logo itself is symbolic – a crest – representing MLF's family-like atmosphere among the league's anglers, sponsors, fans and host communities.
"A crest is also the highest point of a mountain, therefore Redcrest is our pinnacle of achievement – the peak of proficiency. Every MLF angler wants to be the best of the best, and all want the right to prove it by first earning an entry into Redcrest, and then winning the event," Rucks added.
The La Crosse County venue knows about family, too, as the area has something for everyone who puts Redcrest on their family calendars for a summer visit.
"We have world-class fine dining, incredible arts, outdoor recreation in hiking, biking, and paddling, a variety of attractions and so much more for the entire family to enjoy. Join us for Redcrest so we can show you an unforgettable experience," said Frels.
La Crosse, Wis., and the scenic Upper Mississippi River region will serve as host to MLF's first tour season championship, the Redcrest. It is scheduled for Aug. 19-25 and will host 30 anglers who qualified by points from the Bass Pro Tour.
It was late last year when Major League Fishing first announced plans of expansion that included the 2019 Bass Pro Tour. The first competition was held in late January, and the series will hit the mid-season mark next week when MLF Stage Four takes place at Dayton, Tennessee, and Lake Chickamauga, April 9-14.
For more information on Redcrest and all MLF news, visit MajorLeagueFishing.com.