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Explore art, architecture and history at Key West Art & Historical Society museums
SPECIAL TO FLORIDA WEEKLY
Above: The Tennessee Williams Museum pays tribute to the great 20th century playwright. COURTESY IMAGES
Did you know that all four museums stewarded by Key West Art & Historical Society — the Custom House Museum, Key West Lighthouse & Keeper's Quarters, Fort East Martello Museum and the Tennessee Williams Museum — are listed in TripAdvisor's "10 Best Museums in Key West" list? And that the Society offers free admission to locals with ID on the first Sunday of each month, free admission daily to Monroe County students with a student ID and $5 admission daily for out-of-county student ID holders at all locations? Here's a sampling of what is happening now at all four museums:
Custom House Museum
The iconic four-story architectural "crown jewel" of Key West, and one of the finest examples of Richardsonian Romanesque architecture in the U.S.
"You Don't Know Dick:
The Lesser Known Works of
Left: "Wish You Were Here: Postcards From Paradise" contains over 2,000 collected and digitized postcards.
Richard Peter Matson"
Bryan Gallery
Key West Art & Historical Society celebrates the work of painter Richard Peter Matson with an exhibition of works that include painted portraits from the 1970s and 1980s, photographic portraits taken as a Yale University graduate student, a series of cards from his successful greeting card business, projects created during his advertising executive days in New York City consisting of mugs and album covers for Columbia Records, decorated Christmas eggs, and paintings of non-Key West subjects such as Maine and the Grand Tetons.
"Wish You Were Here: Postcards
From Paradise"
Bumpus Gallery
Through August 11, 2019
Above: Stanley Papio kinetic sculptures are displayed at the Fort East Mortello Museum. Right: The 171-year-old, 75-foot Key West Lighthouse and Keepers Quarters are one of the most visited historic locations in Key West. COURTESY PHOTOS
"Wish You Were Here: Postcards From Paradise" showcases more than 130 years' worth of vintage images taken from Key West Art & Historical Society's archives, a repository that contains over 2,000 collected and digitized postcards. The exhibit features aesthetically engaging cards in original, reproduction, and enlarged formats as well as information on the many facets of postcard collecting and their influence on social, economic, and architectural history.
Guy Harvey's "The Old Man and The Sea"
Fifty-nine original pen-and-ink drawings inspired by Hemingway's novel of the same name, created by internationally acclaimed artist and conservationist Guy Harvey and completed when he was a teenager.
"Overseas to the Keys: Henry
Flagler's Overseas Railway"
Dogwood Gallery
Celebrating an important part of Florida Keys history and the incredible engineering feat that joined Key West to mainland Florida, outstanding elements include a reproduction railroad car that transports visitors back to the early 1900s, an over-sized map of the Florida Keys, home video shot from the railroad in the 1920s, and related objects and ephemera from The Society's permanent collection. Supported by the William R. Kenan Jr. Charitable Trust, Thomas Kenan, the Monroe County Tourist Development Council, and Lamont Harris.
"Tennessee Williams –
The Playwright and the Painter"
Inner Vecchie Gallery
One of the most prolific playwrights of the 20th century, and a Key West resident for more than 30 years, Tennessee Williams took up painting in the 1960s. The Inner Vecchie Gallery showcases 15 of his paintings dating from the 1970s, all bequeathed to Key West Art & Historical Society by friend and benefactor David Wolkowsky.
Fort East Martello Museum
3501 South Roosevelt Blvd.
Constructed to provide protection for Key West against the possibility of an enemy invasion and now one of the only examples of Martello-style military architecture in the United States.
"Stanley Papio – Junkyard Rebel"
Namesake of the annual Key West Art & Historical Society Papio Kinetic Sculpture and Art Bike Parade, Stanley Papio saw art where others saw junk. For more than three decades, the rebellious welder-turned-metal-artist transformed the "trash" in his Key Largo yard into extraordinary works of art, many of them a comical and caustic commentary on neighbors and naysayers. Today, more than 100 sculptural objects and three-dimensional constructions are housed at the Fort.
"Ghosts of East Martello"
Pay your respects to Robert, the world's most famous haunted doll, whose mesmerizing and eerie history began just after the turn of the 20th century when he was created by the Steiff Company and given to young Gene Otto, son of a prominent Key West doctor. Delve into the bizarre but true lore of Carl Tanzler, the self-proclaimed Count von Cosel, and his passion for the beautiful but deceased Elena Milagro Hoyos Mesa, with whose body he lived until 1940 — when he was arrested for grave robbery and possession of a dead body.
Key West Lighthouse & Keeper's Quarters
One of the most visited historic locations in Key West
Explore the Lighthouse Keeper's Quarters, now a museum restored to an early 1900s appearance with historic furnishings, photos and original artifacts depicting the life and times of generations of lighthouse keepers and their families. Climb the 88-step, circular, iron stairway of the 171-year-old lighthouse, owned by Monroe County and operated by Key West Art & Historical Society. Once a beacon for the island with its Fresnel lens that shined 11 nautical miles out to sea, the 75-foot tower also served to guide those on land. Ernest Hemingway, who once lived across the street from the structure, was known to use it to find his way home after nights of drinking.
Tennessee Williams Museum
513 Truman Ave.
Pays tribute to one of the greatest 20th century American playwrights
A destination for Tennessee Williams enthusiasts and scholars, the exhibit showcases highlights from his life and work while living in Key West from 1949 until his death in 1983. The collection of historic, archival materials keeps alive the importance of his legacy and offers the largest collection of Williams' memorabilia and literary artifacts available to the public. Displays include artist Jane Rohrschneider-Carper's model of the playwright's home at 1431 Duncan St., first edition plays and books, images from late local photographer Don Pinder, and original steps from the film adaptation of Williams' play "The Rose Tattoo," which was filmed entirely in Key West.
For more information on these and other Society exhibits — including WPA art and works of folk artist Mario Sanchez — along with hours of operation, membership and volunteer opportunities, visit kwahs.org. Your museums. Your community. It takes an island. ¦
More From Arts and Entertainment News Go To The Arts and Entertainment News Section
KEY WEST HAPPY HOUR GUIDE
Surf's up at Fort East Martello:
KEY WEST GALLERY GUIDE


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Железосерные кластеры (также Fe—S-кластеры) — элементоорганические соединения, группа белковых кофакторов, обладающих окислительно-восстановительным (Red/Ox) потенциалом в районе от  до . Red/Ox-потенциал зависит от структуры и конформации белка, что делает эти кофакторы важнейшими участниками окислительно-восстановительных реакций в клетке. Железосерные кластеры способны принимать или отдавать электроны (см. рисунок). Белки, содержащие железосерные кластеры, являются эволюционно древними и распространены во всех царствах, включая животных, растения, грибы, бактерии и археи. Мутации по генам метаболизма Fe—S-кластеров являются причиной многих тяжёлых заболеваний или летальны.

Происхождение
На начальном этапе развития жизни Земля имела восстановительную атмосферу, отсутствовал кислород, вулканическая активность сопровождалась выбросами сероводорода, а в океане было растворено значительное количество двухвалентного железа. Как будет раскрыто ниже, из элементов именно в этих (Fe и S) степенях окисления синтезируются новые железосерные кластеры в клетках живых организмов. Предположительно, неорганические структуры, подобные железосерным кластерам, образовывались в таких условиях спонтанно, а древние живые организмы приспособили данные структуры, включив их в состав белковых молекул.

Способность переносить электроны у образовавшихся белков оказалась тесно связанной с обменом энергии в клетках, поэтому эти ферменты продолжали эволюционировать, и их гены закрепились во всех живых организмах.

Функции
 Железосерные кластеры способны получать, отдавать, переносить или накапливать электроны. Это их свойство делает возможным работу таких важных белков, как, например, белки цикла трикарбоновых кислот (цикла Кребса, ЦТК) аконитаза и сукцинатдегидрогеназа, или комплексы I—III дыхательной электронтранспортной цепи.
 Жесткая структура Fe—S-кластеров, как правило, встраиваемых в молекулы белков ковалентно через остатки цистеина (Cys) или гистидина (His) (см. ), стабилизирует белки в определённой конформации, делая ферменты со встроенными кластерами совершенно непохожими на их аналоги без Fe—S-кластеров. Такие белки отличаются своей конформацией, каталитической активностью, способностью связывать лиганды и другие белки и временем жизни.

Биосинтез

Общие сведения
Модельными организмами для изучения синтеза и передачи железосерных кластеров в клетке являются дрожжи , , ,  и многие другие организмы; исследуются эти процессы и на клетках человека.

Для бактериальных организмов известно три системы белков, участвующих в синтезе железосерных кластеров:

 NIF ( — система азотфиксации). Участвует в синтезе металлокластеров нитрогеназ.
 ISC (). Кодируются в isc-опероне, необходимы для синтеза жизненно необходимых клеточных железосерных белков.
 SUF (). Кодируются suf-опероном, работают преимущественно при окислительном стрессе или недостатке Fe.

Для эукариот выделяют четыре системы:
 ISC (система родственна бактериальной). Ферменты локализованы в митохондриях и необходимы для синтеза и передачи кластеров для всех остальных белков клетки.
 SUF (система родственна бактериальной). Ферменты присутствуют у растений, из-за большей устойчивости к кислороду локализованы в пластидах.
 система экспорта ISC (). Необходима для транспорта железосерных кластеров из митохондрий в цитоплазму.
 Fe/S-аппарат внедрения (). Локализован в цитоплазме. Необходим для передачи железосерных кластеров к ядерным и цитоплазматическим Fe—S-белкам.

В качестве основного модельного организма для описания выберем дрожжи (), это необходимо, чтобы не создавать путаницу в названиях белков, гомологи которых в разных организмах называются по-разному.

Сборка железосерного кластера
Для непосредственного синтеза необходимо образование комплекса белков Nfs1 и Isu1. Nfs1, кроме функции образования комплекса, выступает в роли донора серы, которая передается с остатков Cys при участии пиридоксальфосфата в качестве кофактора. Isu1 крайне важен для сборки всего кластера, так как он принимает донируемые атомы серы и Fe и укладывает их необходимым образом для образования 2Fe—2S- или 4Fe—4S-кластеров за счёт собственных остатков Cys.[2,3]

У дрожжей также существует изоформа Isu2, образованная дупликацией гена Isu1. Обе изоформы могут принимать участие в синтезе кластеров.

Также показано, что для образования железосерных кластеров необходимо связывание Nfs1 с гораздо более мелким белком Isd11. Этот механизм возник эволюционно давно, так как присутствует во многих организмах.
Было показано, что источником железа является Yfh1 (у человека frataxin). Его связывание с собранным комплексом белков стимулирует формирование готового железосерного кластера на Isu1.
Ионы железа должны быть доставлены в митохондрии через малопроницаемую внутреннюю мембрану. Этот процесс осуществляется митохондриальными транспортерами Mrs3 и Mrs4, которые могут пропускать только Fe. Это железо и связывается Yfh1. Возможны и другие пути транспорта железа в матрикс митохондрий.

При создании кластера сера должна быть восстановлена до степени окисления −2. Электроны передаются от NADH через ферредоксин Yah1 и ферредоксин-редуктазу Arh1.

Изъятие железосерных кластеров
В изъятии сформированного кластера из Isu1 главную роль играет шаперон Ssq1 (из семейства HSP70), кошаперон Jac1 и фактор обмена нуклеотидов Mge1. Известно, что Jac1 активирует АТФазную активность Ssq1, эта энергия расходуется на взаимодействие с высококонсервативным участком Isu1, из-за чего Fe—S-кластеры оказываются доступны для передачи в другие белки. Фактор обмена нуклеотидов Mge1 нужен для извлечения АДФ из Ssq1.

У бактерий фактор обмена нуклеотидов не обязателен.

Передача доступных кластеров с Isu1 к белкам-реципиентам может осуществляться напрямую или через белки-посредники, например Grx5.

Передача железосерных кластеров белкам матрикса
Одни из важнейших белков, содержащих Fe—S-кластеры, в матриксе — аконитазы Aco1 и Lys4, биотинсинтаза Bio2 и синтаза липоевой кислоты Lip5. Передача кластеров к этим белкам осуществляется только при наличии белков Isa1 и Isa2, и связывающегося с ними обоими белка Iba57. Фенотипы грибов с подавленной экспрессией Isa1, Isa2, Iba57 схожи, а данные об их взаимодействии указывает на участие в одном процессе.

Транспорт из митохондрий
Митохондрии — двумембранные органеллы эукариотической клетки. Многие вещества плохо транспортируются сквозь гидрофобный слой мембран, поэтому для митохондриального транспорта существуют сложные белки-переносчики, каналы и рецепторы. Как правило, наиболее сложной задачей является транспорт через внутреннюю мембрану митохондрий, на которой в норме поддерживается мембранный потенциал, необходимый для работы АТФ-синтазы. Для создания этого потенциала мембрана должна быть крайне слабо проницаемой даже для протонов. Естественно, что транспорт сквозь такую мембрану связан с повышенными трудностями.

Транспорт молекул весом менее  сквозь внешнюю мембрану митохондрий осуществляется сквозь пори́н (белок VDAC), позволяющий проходить даже небольшим белкам. Наличие поринов во внешней мембране делает межмембранное пространство (ММП) схожим по составу с цитоплазмой, за исключением белкового состава.

Внешняя мембрана митохондрий гораздо более удобна для исследований, поэтому пути транспорта сквозь внутреннюю мембрану менее изучены.

На данный момент неизвестно, в составе каких молекул железосерные кластеры транспортируются из митохондрий[2,3], однако поиск этого переносчика представляется крайне интересной задачей, так как, помимо доставки кластеров, этот компонент может принимать участие в регуляции метаболизма клетки, в том числе в контроле концентрации железа в клетке и в митохондриях, а также влиять на транскрипцию и трансляцию целого ряда генов. Вместе с тем считается, что транспорт сквозь внутреннюю мембрану осуществляется сквозь Atm1 (белок из семейства АВС-транспортеров), который обладает АТФазной активностью. Эта активность увеличивалась при добавлении пептидов с доступными группами —SH цистеинов. Так как обычно активность ABC-транспортеров индуцируется транспортируемыми ими компонентами, вероятно, гипотетический переносчик содержит свободные группы —SH.

Транспорт облегчается сульфгидгидоксидазой Erv1, растворенной в межмембранном пространстве (ММП) митохондрий. Для Erv1, помимо каталитической активности, связанной с окислением групп —SH, показана возможность обеспечивать транспорт в ММП, обусловленный образованием связей S—S.

Третьим необходимым для транспорта из митохондрий компонентом является глутатион.

Цитоплазматическая передача/синтез
Для дрожжей предполагается отсутствие синтеза железосерных кластеров в цитоплазме, однако, в клетках млекопитающих синтез Fe—S-кластеров за пределами митохондрий протекает наравне с синтезом в митохондриях. При этом значение митохондриального синтеза оказывается выше, если судить по реакции клеток в ответ на пониженный объём синтеза (запускаются механизмы «экономии» уже имеющихся кластеров и увеличивается концентрация Fe в митохондриях).

У дрожжей железосерные кластеры из митохондрий передаются на белки Tah18 и Dre2. Далее кластеры принимает димер Cfd1-Nbp35, который может взаимодействовать с другими белками и передавать им железосерные кластеры, необходимые для созревания этих белков. В процессе передачи участвуют два белка-адаптора: Nar1 и Cia1. Показано, что Nar1 сам по себе содержит Fe—S-кластеры и образует комплексы с Cia1 и Nbp35. Cia1 по структуре является бета-пропеллером и, вероятно, способен помогать взаимодействию белков-акцепторов Fe—S-кластеров с несущим их комплексом Cfd1-Nbp35-Nar1.

На клетках человека показано, что человеческие аналоги huNfs1, huIsu1, huNfu1, frataxin имеют изоформы без сигналов митохондриальной локализации (huNfs1, huIsu1, huNfu1 при трансляции со второго старт-кодона не получают эти сигналы) и присутствуют в меньших количествах в цитоплазме и ядре. Это присутствие строго необходимо в норме, так как без него запускаются сигналы, увеличивающие содержание Fe в клетке и митохондриях, уменьшающие синтез гемов и расход железосерных кластеров. Вероятно, таким образом клетка осуществляет контроль за нормальным синтезом кластеров и пытается предотвратить собственную гибель при их недостатке.

Синтез в эукариотах, утративших митохондрии
Некоторые паразитические организмы в ходе эволюции утратили митохондрии вместе с осуществляемыми в них процессами синтеза гемов и дыхания. Однако без синтеза железосерных кластеров обойтись они не смогли, поэтому в их гидрогеносомах (редуцированных митохондриях) есть аналоги систем синтеза железосерных кластеров. Примерами таких организмов являются лямблии и микроспоридии.
Из этого правила существуют и исключения, например, у  белки Isu1 и frataxin расположены в цитоплазме, а Nfs1, Isd11 и Ssq1 — в митосомах; а у  системы ISC найти не удалось, но есть гомологи белков NifS и NifU.

Регуляция метаболизма
Обычно самые важные процессы в клетке имеют несколько путей осуществления, чтобы в случае поломки основного механизма выжить за счёт наличия запасного (примерами могут служить различные варианты репарации ДНК, взаимодополняющие друг друга процессы апоптоза и некроза). В данном случае альтернативных путей синтеза железосерных кластеров не возникло, поэтому осуществляется строгий контроль за его работой. В данном случае контроль многократно дублируется.

Регуляция концентрации железа
Так как смещение количества реагентов смещает равновесие реакции в сторону образования продуктов, то при увеличении количества доступного железа должно возрасти количество собираемых железосерных кластеров.

Так как белки синтеза и транспорта железосерных кластеров кодируются в ядре (даже если они локализованы в митохондриях), то в случае поломки сигнал должен дойти до ядра.

Очень важную роль в регуляции метаболизма железа играют транскрипционные факторы Aft1 и Aft2. Aft1 при понижении уровня железа в клетке транспортируется в ядро с помощью импортина Pse1 и взаимодействует с генами так называемого регулона железа (), активируя их транскрипцию. Среди этих генов есть гены транспортёров железа, которые увеличивают общее количество железа в клетке.

Ещё одной мишенью Aft1 является РНК-связывающий белок Cth2, который под действием Aft1 начинает уничтожать матричные РНК использующих железо белков, уменьшая потребление железа.

Механизма детектирования уровня железа белком Aft1 доподлинно не известно. Предполагается, что митохондрии экспортируют некий фактор, напрямую связанный с интенсивностью работы аппарата синтеза железосерных кластеров. Одним из кандидатов на роль данного фактора является белок-переносчик железосерных кластеров из митохондрий, передающий кластеры цитоплазматической системе CIA ().

Aft2 считается более мягким и медленным регулятором, фенотипически оказывающим тот же эффект, что и Aft1.

Регуляция синтеза железосерных кластеров
Первым ферментом, воспринимающим недостаток Fe—S-кластеров, является фермент IRP1, который может включать Fe—S-кластер в свою структуру и имеет разные конформации — с кластером и без кластера. Он располагается в цитоплазме и получает кластер от системы CIA, поэтому чувствует все поломки в системе синтеза и транспорта Fe—S-кластеров.
Без Fe—S-кластера IRP1 имеет каталитически активный домен, взаимодействующий с IRE () РНК некоторых белков. Существует 2 типа взаимодействий:
 связывание мРНК с IRP1 на 5'-конце блокирует трансляцию (рибосома застревает и не синтезирует пептид) таких белков, как ферритин и ферропортин (связывают и выводят железо из клетки), ALAS2, митохондриальная аконитаза (эти белки «тратят» железо и железосерные кластеры).
 связывание мРНК с IRP1 на 3'-конце защищает её от 3'-экзонуклеаз, обеспечивая накопление мРНК и повышенный синтез некоторых генов, например рецепторов трансферрина (связывают катионы железа и при попадании в эндосому те проникают в цитоплазму) или DMT1 (неселективный транспортер дивалентных катионов, в том числе и железа. Эти белки увеличивают содержание железа в клетке и митохондриях.

Помимо IRP1, в клетке присутствует фактор IRP2, который действует аналогично IRP1, однако не содержит железосерных кластеров, и механизм чувствительности IRP2 пока не определён.

Созревание тРНК
тРНК имеет устойчивую третичную структуру, обеспечиваемую образованием комплементарных взаимодействий и водородных связей внутри самой цепи РНК. Для участия в трансляции синтезированная тРНК должна правильно свернуться и претерпеть некоторые изменения. Одним из таких изменений является тио-модификация урацилов U34 и U35 у дрожжей и млекопитающих в цитоплазматических и митохондриальных тРНК. Тио-модификации есть и у бактерий.

Данные модификации зависят от Fe—S-содержащих белков, и нарушения в их синтезе вызывают повсеместные нарушения в трансляции, приводят к гибели. Механизм, посредством которого осуществляется связь между синтезом Fe—S-кластеров и данной модификацией, на данный момент изучен мало.

Железосерные кластеры и окислительный стресс
Ионы железа являются хорошим неорганическим катализатором распада перекиси водорода. Перекись распадается на гидроксильные радикалы, которые крайне активны и опасны для клеток. Радикалы в первую очередь запускают перекисное окисление липидов мембран митохондрий, а также их ферменты и ДНК. Митохондрии работают с кислородом и могут образовывать его активные формы (ROS — reactive oxygen species). Таким образом процесс замыкается, ускоряется, а митохондрии и вся клетка портится, в результате чего она может гибнуть от апоптоза/некроза или переродиться в раковую из-за мутаций.

Как было показано выше, нарушения в работе аппарата синтеза железосерных кластеров приводят к увеличению количества железа, а значит, и катализаторов образования активных форм кислорода.

Общие моменты, вызываемые нарушениями синтеза/транспорта железосерных кластеров
Заметим, что нарушение по любому из генов синтеза или транспорта железосерных кластеров блокирует (как минимум у дрожжей) их доставку в цитоплазму, поэтому часто симптомы заболеваний схожи.

Обычно эти заболевания очень редки, связаны лишь с нарушением или уменьшением синтеза Fe—S-содержащих белков, так как полное отсутствие тех или иных белков обычно летально.

 уменьшается клеточное дыхание (а значит, и продукция АТФ)
 уменьшается активность цикла Кребса (снова меньше АТФ, а также сильно нарушается метаболизм)
 уменьшается синтез гемов (результат — анемия)
 уменьшается синтез эргостерола
 уменьшается синтез биотина
 увеличивается концентрация железа в клетке и, в частности, в митохондриях

Заболевания
 Атаксия Фридрейха. Обусловлена мутациями по гену FXN (кодирующему белок фратаксин).
 . Характеризуется малыми эритроцитами, малым количеством гемоглобина. Мутации по гену .
 . Протопорфирия, характеризуется повышенной чувствительностью к свету, пониженным синтезом гемов. Мутации по гену  (снижен транспорт железа в митохондрии).
 мутации по генам Arh1, , комплексам I иII дыхательной цепи приводят к окислительному стрессу в клетках, ракообразованию или усиленному апоптозу либо некрозу клеток, плюс в случае комплексаI — оптической атрофии Лебера, митохондриальной энцефаломиопатии, лактозному ацидозу и другим заболеваниям.
 Мутации по генам  и , а также по гену, кодирующему белок , приводят к нарушениям репарации ДНК и заболеваниям: раку толстого кишечника, анемии Фанкони и ксеродерме, соответственно.

Примечания

Митохондрии
Коферменты
Метаболизм

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There is something about staying in the caravan that the kids absolutely love. It is probably the same reason why my brother and I loved it when we were kids. The whole experience they just soak it up and love doing all the things you need to do when in a caravan – changing the water, the toilet, the waste and of course getting setup including putting the awning up etc.
The video above shows a time lapse photography taken with my iPhone of the caravan setup. It was taken over a period of about 20 minutes – if my Maths is correct!
On the first day we decided to head out to one of the local wildlife centres, oddly named Pili Palas. Initially this started out as a butterfly centre and although the butterflies still remain there are a whole host of other things to see including pets corner, pigs, goats, lizards and even some Llamas.
There was also lots of activities for the kids to do including play areas and picnic spots. In fact we took some sandwiches and found a nice picnic area near the outdoor play area to have our lunch.
We stayed not far away from Benllech which has a very nice beach. In fact on a hot day it would rival anything you see down in Cornwall. We went for a long stroll across the sands and there are some stunning views.
After a lovely BBQ the evening before, the next morning we headed out to visit Beaumaris Castle in the south of Anglesey. With James recently studying castles at school he was super excited to visit one for real.
On arrival James was quick to point of some of the castle features, immediately should out "arrow slits" and "moat" when he saw them – he must have been paying attention in class!
The castle was lovely and visitors are free to move around at their leisure. You can walk around the top of most of the inner and outer castle walls as well as exploring many of the small rooms in the castle. Makes you think what life would have been like living in one.
We had a lovely time in Anglesey and I would highly recommend a visit if you get the chance.


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Thought you would all love this. I heard about the blog last week and never had a chance to post a link.
I am so glad you chose the Golden Gate Bridge. It is an entry way into America's most profligate city. Also glad you chose Penicillin because it greatest use has been the cure of Sexually Transmitted Disease, a hallmark of the progressive, permissive, life style promoted by the liberal left. Then finally, the minimum wage. Another liberal incentive not to better oneself. Perfect choices…..and all of them younger than John McCain.
thanks for the shoutout on the blog… and to 'reaganite': well,you're a whole basket of crazy, now aren't you?


An office desk gets personality.
One of our editors (who shall remained unnamed) desperately needed a desk overhaul. Enter celeb stylist Brad Goreski to the rescue. See how he gave this office space some personality with a classic color combination. Plus, get his top 5 tips for styling a desk.
There wasn't anything wrong with this editor's desk, it just needed to show off her personality more. "It's a good thing to personalize your desk to make it your own and create a space you actually want to spend time in, since you're there most of the day," Goreski says.
Goreski started with the Mykonos line from the Post-it Brand Colors of the World Collection as inspiration. He used blue-and-white fine paper from Paper Source as a placemat. "I love the blues and whites, it makes me dream of the Mediterranean and going for a swim," he says. "I think the placemat does a good job of setting the tone, of pulling all the colors in together and creating an illusion of staring into the water when you're actually staring at your desk."
"Fresh flowers are always in my home and on my office desk," he says. "It's a good way to bring the outdoors indoors and also gives a nice scent. There's something very romantic about flowers."
A decorative stapler from Anthropologie goes with the blue-and-white color scheme. A ceramic bowl from Paper Source adds a pop of orange and corrals paper clips, push pins, and more. "I have a little bowl from my travels in Africa that's made out of telephone wire on my desk and I put little knickknacks in there," he says. "You can keep your space personal by displaying things from your travels and keeping color around you."
"When styling my clients, I love a little bit of sparkle," Goreski says. "I think that's also an important element to bring into your surroundings as well. It reminds me to lighten up and not take things too seriously." To bring in some shine, he added a beaded canister, an Oscar de la Renta cup and saucer, and a Kate Spade gold polka dot notebook to the desk. "Instead of drinking out of a paper cup, I think it's nice to use a piece of china," he says. "I also like incorporating the polka dots as well because it's a little offbeat, but works with the gold rim on the cup. I like things that are a little bit unexpected."
"You should have a lot of fun mixing color and patterns and making your space lively and personal," Goreski says. "Let it say something about you."
The Trina Turk pillow, paper and binder clips, and pens give the blue-and-white space more color. "I tied in a few other accent colors, like the yellow Post-it Note and the graphic pillow," he says. "They give the space a little more zest and energy."
Want more amazing transformations? Check out all of our favorites in our month-long makeover obsession, MAYkeover!


text:
Inger Lise Blyverket (born 2 March 1969) is a Norwegian civil servant, and director-general of the Norwegian Consumer Council.

She hails from Groruddalen in Oslo. In the early 20s she discovered being lesbian, and subsequently became deputy leader of the National Association for Lesbians, Gays, Bisexuals and Transgender People (now the Norwegian Organisation for Sexual and Gender Diversity). After completing her teacher education she worked as a lower secondary school teacher, before she became a teachers' trade unionist in the Union of Education. She then became director of negotiations in the employers' association Enterprise Federation of Norway. In 2019, she became the director-general of the Norwegian Consumer Council.

References

1969 births
Living people
Civil servants from Oslo
Directors of government agencies of Norway
Norwegian lesbians
Trade unionists from Oslo


I think it's safe to say that we all have that one film in the Marvel Cinematic Universe that we don't like. Not everything this cinematic universe offers is phenomenal after all. For me, that one film has always been Ant-Man. I've defended other entries that most people seem to hate like Thor: Dark World or Iron Man 3. Ant-Man was a film that had great moments like Louise's screen stealing electricity or the fact that Baskin Robbins always knows. So I was a bit less than enthused when a sequel was announced.
Ant-Man and The Wasp is the follow-up to 2015's Ant-Man. Here we are reunited with our heroes following the events of 2016's Captain America: Civil War. When I say hero I guess I just mean Paul Rudd's "Scott Lang" or "Ant Man". This entry into the MCU is set prior to the events of Avengers: Infinity War. At its' core, Ant-Man and the Wasp tells the story of Michael Douglas' "Hank Pym" & Evangeline Lilly's "Hope van Dyne" trying to enter into the quantum realm to save Michelle Pfeiffer's "Janet Van Dyne".
While the film does deal a lot with the sub atomic world below, it is big on the surface. That's one thing I truly do appreciate about this film is its' boldness. It boldly and brilliantly expands the Marvel Cinematic Universe in the new territory, similar to that of 2014's Guardians of the Galaxy, with the cosmos. The scenes within the quantum realm really allow for a beautiful visualization showcase. Even past the quantum realm, there is some much of this film that is a visual treat to the eyes. Even the film's intro with deaging Michael Douglas and Michelle Pfeiffer is astonishing. Take Hannah John-Kamen's "Ghost", every movie she makes is a haunting visual masterpiece.
Let's just keep the subject of Ghost going. With the MCU, usually the downfall of these films are the villains being too generic or underdeveloped. This film contains two villains. I'll get to the second one in just a second. However, Kamen's villain is extremely underutilized throughout this film. She has reasonable motive but she is kind of sidelined in the film for other plot points that really don't serve the overall plot. Ghost actually does have something to do with this plot. Unfortunately, as much as I loved her character, she is a missed opportunity for the film.
Which brings me to villain number two - Walter Goggins' "Sonny Burch". Burch should have just been a throw away character in all honesty. He's set-up in a scene of the film, which pushes the plot forward but and also introduces Ghost. He should have been nothing more than a glorified cameo. Like flies, he just keeps coming back. Ultimately becoming a thorn in the film's side.
While there is an annoying nature to the handling of some of these characters. Paul Rudd is just as charming as he has been in his previous appearances as the character. Proving once again he was right for the role of Lang. Lilly's portrait of The Wasp is fantastic. Our introduction alone to her abilities is enough to leave you breathless. The chemistry alone with your core trio - Douglas, Rudd & Lilly - is electric and makes you anxious to see what comes next.
Overall, Ant-Man and The Wasp, is a fun film period. It opens up the MCU to new terriorites and breaks ground visually. The main cast of Rudd, Douglas and Lilly perform above and beyond in both comedy and action. However, it does continue the streak of underdeveloped and unwanted villains with Ghost and Burch. Ghost proves Marvel really did have a missed opportunity on their hands. They could have been three for three with villains in 2018 behind Black Panther's Killmonger & Avengers: Infinity War's Thanos. While Burch, on the other hand, was just a waste of screen time.
If you or someone you know is struggling with suicide, depression, self-harm or addiction, please feel free to reach out, use any of our resources, call the suicide life line: 1-800-273-8255 or text 741-741.
Ant-Man and The Wasp images used here are property of Disney & Marvel. We do not own any rights, nor do we claim them.


The Economic Offences Wing of the Mumbai Police reported that more than 5,000 home buyers were cheated of Rs 3,683 crore. 123 cases were reported in the city in the past three years.
Police officers said that the buyers wait thinking that the construction will begin some day or the other. But the end of this long wait is met with unbearable losses.
There are multiple reasons for this delay in completion of projects. One reason is that builders collect funds in the name of one project and divert it to other projects.
The complaints are pertaining to projects that started between 2009 and 2015. 32 cases worth Rs 1,087.5 crore were registered in 2016. 50 cases worth Rs 1,085 crore and 41 cases worth Rs 1,510.5 crore were reported in 2017 and 2018 respectively.
Some builders in hope of getting extra floor space index wait for positive changes in the real estate policies and rules, thus causing further delay.
In other instances, the builders sell the same flat to multiple individuals or sell flats on the additional floors which are yet to get permission from the authorities.
Selling flats that are already mortgaged with a bank is also a common practice.
Assistant police commissioner from EOW, said that the investigation of arrested developers and builders revealed that they were dependent on the black market. The pressure to conduct business in white and the demonetisation made an impact on those relying on black market. This broke their backbone leading to mass frauds.
Ramesh Prabhu, president of Maharashtra Societies Welfare Association pointed that builders keep on circulating the money and the result is many incomplete projects with no money left to complete them.
The buyers' ignorance also encourages builders to commit such frauds. It was observed that most buyers are interested in recovering their money and don't wish to prosecute the builders.
One of the victims fighting against the builders suggested that the police apply sections of Maharashtra Protection of Interests of Depositors Act to help get their money back. The attached assets can be sold to repay the cheated buyers. But MPID Act is limited to investment frauds.
Advocate Vinod Sampat, president of Cooperative Societies Association and a real estate expert said that home buyers can approach the consumer or civil court even after filing a complaint.
The victims of old projects can complain to RERA if their matter is not sub judice and the builder/developer has not yet received the OC.
Avoid paying in cash and always pay directly to the builder.
Check whether the floor on which you booked the flat has been sanctioned by the authorities.
Avoid paying the entire amount if the building is under construction.
Verify if the builder has a commencement certificate.
Conduct a background check of the builders.
Check if the flat is already sold to someone.
Find out the title-holder of the land where the construction is being carried out.


Invitation to private sector, NGO's and government to challenge our findings.
10:30 -12:30: Challenges of Pond Aquaculture and Benefits of Bioflocs Related Innovations. Session with 8 speakers, among whom Prof. Verdegem and Emeritus Prof. Sorgeloos.
13:30 – 15:00: Approaches to Design and Adoption of Innovations in Aquaculture. Session with 6 speakers among others from Wageningen University and WorldFish.
15:30 – 17:00: How can Innovations in Aquaculture Contribute to Inclusive & Sustainable Business?
Inclusive Business and Sustainable Trade.
If you intend to join the International Fisheries Symposium (19 to 21 November), including the workshop: please register through the IFS website.
Session organised by NWO-GCP projects of Wageningen University & Research, Prince of Songklia University, Can Tho University, Diponegoro University, York University and EURASTiP.
EURASTiP launched in SE Asia !
Promoting Multi-Stakeholder Contributions to International Cooperation on Sustainable Solutions for Aquaculture Development in South-East Asia.


This is acid! It was a hard job to find those 25 toxic pearls in the shallows of netlabel world. L'embrouille mixed a freaky monster out of them. If you want more: Each wednesday he has a live show on livesets.com radio.
Old school tweeeeaks... nice to see :) Boisk!
Excellent mix - must have taken ages to find all those great tracks.
Yeah, thanks to everybody. really glad that acid is still alive.
great job! true acid, 100% vip ! greetz from moscow. bI bI !
This is banging Acid. Great job, i like the ambient style!!!
thanx for this amazing sound!
simply fantastic! thank you very much!
could you imagine to create a set especially for Analogue Mind Control Network?
Thank you for the acidfever!!!
This is how I like it!!!!
Great job man!!! Thank you very much!!
wow, this is really hot.


text:
require 'mime-types'
require 'rof/filter'
module ROF
  module Filters
    # Expand objects of type "Work(-(.+))?" into a
    # constellation of "fobjects".
    # Makes a fobject/generic_file for each file
    # adds a depositor
    # turns original object into an fobject/$1
    # and copies the access to each fobject.
    class Work < ROF::Filter
      class NoFile < RuntimeError
      end

      def initialize(_options = {})
        @seq = 0
      end

      # wade through object list
      def process(obj_list)
        obj_list.map! { |x| process_one_work(x) }
        obj_list.flatten!
      end

      # given a single object, return a list (possibly empty) of new objects
      # to replace the one given
      def process_one_work(input_obj)
        model = decode_work_type(input_obj)
        return [input_obj] if model.nil?

        main_obj = input_to_rof(input_obj, model)

        # make the first file be the representative thumbnail
        thumb_rep = input_obj['representative'] # might be nil
        result = [main_obj]
        input_obj['files']&.each do |finfo|
          file_rof = make_file_rof(finfo, main_obj['pid'], input_obj)
          if thumb_rep.nil?
            thumb_rep = file_rof['pid']
            main_obj['properties'] = ROF::Utility.prop_ds(input_obj['owner'], thumb_rep)
          end
          result << file_rof
        end
        result
      end

      def make_file_rof(finfo, main_pid, input_obj)
        if finfo.is_a?(String)
          fname = finfo
          finfo = { 'files' => [fname] }
        else
          fname = finfo['files'].first
          raise NoFile if fname.nil?
        end
        finfo['rights'] ||= input_obj['rights']
        finfo['owner'] ||= input_obj['owner']
        finfo['bendo-item'] ||= input_obj['bendo-item']
        finfo['metadata'] ||= {
          '@context' => ROF::RdfContext
        }
        finfo['metadata']['dc:title'] ||= fname
        finfo['representative'] = nil
        finfo['rels-ext'] = { 'isPartOf' => [main_pid] }
        f_obj = input_to_rof(finfo, 'GenericFile')
        f_obj['content-file'] = fname
        mimetype = MIME::Types.of(fname)&.first&.content_type || 'application/octet-stream'
        f_obj['content-meta'] = {
          'label' => fname,
          'mime-type' => mimetype
        }
        f_obj['collections'] = finfo['collections']
        f_obj.delete_if { |_k, v| v.nil? }
        f_obj
      end

      def input_to_rof(input_obj, model)
        {
          'type' => 'fobject',
          'af-model' => model,
          'pid' => input_obj.fetch('pid') { next_label }, # only make label if needed
          'bendo-item' => input_obj['bendo-item'],
          'rights' => input_obj['rights'],
          'properties' => ROF::Utility.prop_ds(input_obj['owner'], input_obj['representative']),
          'properties-meta' => { 'mime-type' => 'text/xml' },
          'rels-ext' => input_obj.fetch('rels-ext', {}),
          'metadata' => input_obj['metadata']
        }
      end

      # Issue pid label
      def next_label
        "$(pid--#{@seq})".tap { |_| @seq += 1 }
      end

      WORK_TYPE_WITH_PREFIX_PATTERN = /^[Ww]ork(-(.+))?/.freeze

      WORK_TYPES = {
        # csv name => af-model
        'article' => 'Article',
        'dataset' => 'Dataset',
        'document' => 'Document',
        'etd' => 'Etd',
        'image' => 'Image',
        'gtar' => 'Gtar',
        'osfarchive' => 'OsfArchive'
      }.freeze

      # Given an object's type, detrmine and return its af-model
      def decode_work_type(obj)
        if obj['type'] =~ WORK_TYPE_WITH_PREFIX_PATTERN
          return 'GenericWork' if Regexp.last_match(2).nil?

          Regexp.last_match(2)
        else
          # this will return nil if key t does not exist
          work_type = obj['type'].downcase
          WORK_TYPES[work_type]
        end
      end
    end
  end
end

redpajama_set_name: RedPajamaGithub


The parties have agreed not to disclose the purchase price. The merger is still subject to the approval of the antitrust authorities.
AVS is a leading specialist provider of highway traffic safety services in Germany. The Company, headquartered in Kuerten, offers all essential services throughout highway traffic-safety projects. These services range from initial planning and obtaining permits to complete construction site setup and security. AVS has a nationwide presence with 14 locations across Germany and around 600 employees.


-Feeling the power of creativity, determination and the will to conquer.
-There is a path although it can't be achieved right away.
-Success if guaranteed if you have been working with passion and pure intention.
-More than "acting" what is important right now is to have Will and perspective of how to make use of a talent.
-The correct choices is unclear and there are too many unknowns in terms of logic.
-Unable or unwilling to make a choice, being faced with two unappealing choices and feeling forced to pick the lesser of two evils.
-Sacrificing something (family or daily life) because of a particular goal.
-Make a clear "black or white" decision about something, and go with instinct and follow the heart.
-Be aware of stagnation, as it is not a time to stand still.
-Drop it all if you are indecisive.
Two in Chokmah, now the power of energy that is born in the Ace is now given direction. This is the first manifestation following the pure idea. The energy is spontaneous, uncontrolled and uninhibited, and the urge is to go ahead first at everything. It is not about achieving a goal. It is more about wanting than acting. If one is not careful this energy can lead to a reckless path.


Mississippi Valley Fair Queen Dana Jamison, a North Scott High School senior from Princeton, joined the fun at Sandyland, a first-time fair attraction at the fair for kids. Jamison is active in 4H and theater, and was crowned fair queen by reigning Miss Iowa Mikhayla Hughes-Shaw. Jamison visited the area named for the late Sandy Coussens, wife of fair board director Rich Coussens.


Sorting out the specifics of your business plan? If so, these Ready Index® Table of Contents Dividers are the order of the day. Visit avery.com for free, easy-to-use templates to tailor the table of contents page to any project. Select the one that best suits your document, key in section titles directly at your desktop and then print the page from your laser or inkjet printer for sharp, standout text. Finally, divide sections of the document with preprinted portrait or landscape formatted tabs. Good arrangement.
For use with 3-ring binders.
Contains 20% post-consumer recycled content.


Have you ever wondered what type of diet top models follow in order to look and feel extraordinary? If so, then the truth is that these girls have a very strict daily schedule. We will talk a bit in this article about top models diet and fitness plan so that you understand exactly how much work they do in order to have amazing bodies.
First of all, top models do not eat sweets. They actually do not eat anything that contains sugar. Therefore, if you plan to lose weight and have a fantastic body then you must definitely quit sugar. In terms of food, they are very strict. They have very difficult diets to follow but if you want the best results then you must definitely make some compromises. Fruits and vegetables are essential in order to look great and feel energized at all time. Water and natural juices are also a very important part of the diet. You will never see a top model drinking milkshake or other drinks that contain anything else but natural fruits. Coffee is permitted but without milk and sugar. Meat is also permitted but rarely and only grilled. Peanuts and many types of seeds play a very important role in a top model diet, as they can make the skin and hair look absolutely beautiful. Seafood is not only delicious but extremely healthy as well, and that's why you will often see these girls eating dishes that contain seafood. A diet rich in vitamins and all sort of nutrients will certainly help you lose the extra weight, stay healthy, and look simply stunning.
Not only the food is very important for top models but the physical activity as well, which needs to be regular. A good fitness plan is essential and without it the results will never be as expected. Top models usually go for running or fitness sessions as these activities give the best results. However, cycling, aerobics, and even yoga could also be excellent choices. A regular physical activity will help burn calories, get rid of the unpleasant cellulite, eliminate the harmful toxins in your body, and beautifully tonify your muscles. A strict fitness plan combined with a strict diet is exactly what top models need in order to look stunning. Furthermore, this is actually what high-class escorts also do. Have you seen how beautiful they are? London is full of high-class escorts who can easily be confused with top models because they are extremely charming and with great bodies. No wonder they are paid so well?! They have to workout quite a lot in order to look like that and this is actually what all women should do in order to look and feel amazing. In order to obtain the desired result you need to educate your body and mind as well. Therefore, any woman who wants to highly improve her appearance should start by following a strict diet and by exercising regularly. By doing so, in a quite short time, the wonderful results will be visible.


This easy soup comes together in about 30 minutes! It is a huge crowd pleaser, especially for kids. Who doesn't love the ham and cheese combo? It would be perfect to serve on Halloween or any busy weeknight!
We made it! We are in our new house! And nobody's in the hospital as a result of moving my piano! It's a miracle.
So far we've only had one flood, which is better than two floods. Look, here I am, being positive! We bought the washer and dryer from our rental house, because we knew they worked and they were cheap. But in our rental, the washer and dryer lived outside in a detached garage. And apparently I never noticed that it leaks occasionally. WHO DOESN'T NOTICE THAT?
Well I noticed yesterday when it flooded our laundry room and soaked the edge of our just-shampooed-earlier-that-day-carpet. (Seriously. The carpet guy came in the morning and it was still damp when dirty water from the washing machine seeps into it.) Welcome to home ownership, where everything breaks and you have to pay for it yourself!
Here's my favorite part. The laundry flooded when Eric was at work, of course. So he comes home and starts poking around, and watches it go through TWO CYCLES with no leaking. You know what this means right? The washing machine will only leak when I am at home alone, and eventually I will start to look like a crazy person who can't do a load of laundry without setting up a chair and popcorn just to babysit it.
Please tell me something broke in your house immediately after you bought it?? This is normal right??
How bout this soup though? I love ham and cheese. I could probably eat a ham and cheese sandwich every day of my life and be happy. But now I have the soup version so I will make this instead. It's tastes exactly like Mac and Cheese, only in soup form, plus chunks of smokey ham. What's not to love?
Do you guys make a ham at Thanksgiving? How bout Christmas? I know that seems like a long ways off, but there are never enough leftover ham recipes in my opinion. Especially since I never wait for after the holidays to make them; I'm a firm believer in the 5-dollar ham steak.
The best part about this recipe? It comes together super fast. We are talking 30 minutes. And thank goodness because who has time for all this cooking when I have washing machines to babysit.
In a medium pot, cook the macaroni according to package directions. Drain as soon as they are al dente. Add a little oil and stir so they don't stick if you are not ready to add them to the soup right away.
Meanwhile, in a large soup pot melt the butter over medium heat.
When it is hot, add the flour and mustard. Use a whisk stir it up.
Slowly whisk in the chicken broth and half and half. Turn the heat up to medium-high, and stir constantly until the mixture comes to a low boil, about 5 minutes.
Immediately reduce the heat to low and stir in the shredded cheese.
Stir in the macaroni and ham. Keep the burner on low until it is as warm as you like.
This is great served with a big salad and bread. If you want some veggies in your soup, frozen peas make the perfect addition. Just add them with the macaroni and heat on low until thawed.
*I used water and 3 and 1/2 teaspoons Better Than Bouillon Chicken Base.
Sometimes I like to add frozen veggies in to make this a little healthier. Throw in some frozen peas in when the soup is done. Or if you want to add frozen broccoli or green beans, add it to the pasta during the last 3-4 minutes of boiling. Super easy!
Source: This recipe is a classic from Land O Lakes! I made a few adjustments.
Easy Cheddar Cauliflower Soup << just made this again the other day. It's probably one of my own personal most-made recipes on my site. Love this stuff.
Cheeseburger Soup << I make no apologies for the pickles in this soup. Just try it.
You guys want to see one of my first posts?? Scary photo alert! But this (super easy) Ham and Potato Soup is still just as good nearly 4 years later…plus it's fun to read about what a paranoid new mom I was since these days I am practically negligent.
And in case you missed it last week…the famous Cowboy Bean Soup!
Cauliflower Soup with Ham and Cheese from Taste and Tell << this sounds like my 2 favorite soups combined!!
I'm so glad you liked it David! It's a classic!
Thank you for all of your easy, and awesome recipes. This is easy, economical and soooooo good!
I'm so glad you liked it Julie! I almost always have the ingredients on hand to make this (ham in freezer) so it really is economical :) Thanks for the review!
Could you please include nutrition in your recipes.
I made the Mac and Cheese soup tonight for my family. I almost doubled it, I'm glad I didn't. It makes a good amount. Even after everyone had seconds, I had four small leftover containers leftover for lunches. We all loved it. Thank you so much for sharing.
I'm so glad you liked it Sarah Jo! Thanks for commenting and leaving a review!
This soup looks delicious! I'm going to make just a few adjustments to be gluten-free for my family. I know it will be so yummy!
Thanks Michelle!! You guys are going to love this one!!
I had to make a couple of adjustments due to ingredients on hand, such as orecchiette instead of macaroni and whipping cream diluted with 1% milk instead of the half-and-half, but I stayed with the required quantities and the spirit of the recipe. It is very good the and luxurious. Reheats beautifully, especially with grated zucchini or peas, as suggested (I tried them both). Now, if only I had a magic wand to make it a low fat, low cholesterol soup, I'd make weekly. But it really delivers in flavor and texture for such a quick recipe and, as an added benefit, appeals to picky eaters.
"Luxurious" is a very good word to describe this recipe Diana! I'm so glad you like it. Thanks for the feedback and review! I love hearing from you!
Has anyone tried to make this gluten free? Buying GF noodles is easy but I haven't tried a flour substitute on a dish like this yet. Our friends' daughter has celiac but loves Mac and cheese so this seems like a no brainer for when they come over if it's possible!
Hey Megan! You could totally make this gluten free! Just use GF flour and GF noodles!
The recipe looks great, and I love Ham and Cheese too, do you still baby sit your washing machine??? HA I know it is just like that with me, call the expert and it does not fail the darn thing calls you a liar and they think you are going senile. HA HA, That I chuckled at.
Fortunately the washing machine is going strong to this day Marie!! So happy to report that they have not committed me to the insane asylum yet for phantom washer floods! Haha!
Yup we were new homeowners we forgot to check the sump pump during the first rain storm. I guess minor flooding is a rite of passage!
Hail to the ham steak! I'm excited to have a new use for them!
Well you know how I feel about cheese….So I'm sure you know my intense feelings for this soup. Love affair!
I'm so nervous…and excited about home ownership for that very reason! BUT if it's any consolation – in our rental, something breaks and the landlords don't fix it…and we're not about to pay for it in a rental, so then we just have to live with it broken.
I think I could eat that Mac & cheese & ham soup every day & the rest look good too. It's inevitable – when we built our house out in the country our yard was nothing but mud. When our brand new washer crapped out after 2 weeks the young newbie repair man they sent came in thru the front door instead of the back & tracked mud thru the entry, across the brand new carpet in the living room, & down the hall. After a couple hours he said he had no idea how to fix it. Funny now, not so much then!
Nooo, the muddy boots!! What is it with men?? Do they not understand carpet? At least it's funny now…I'm sure my washing machine flood will be funny in a few years too…at least I hope so!! :) Thanks Leslie, enjoy the soup!
You are not alone! When we moved into our house the fridge and dishwasher quit and there was a family of mice living in the oven! Now this soup is awesome! My husband hates soup but loves mac and cheese so thank you for a solution!
Your soup looks so delicious and "homey" perfect to enjoy in your beautiful new house! Your house….yep, you're not alone, this happens all this time! My friend is a realtor and when we bought our home she gifted us with a one year home warranty – saved $$$'s!!! Something breaks (and it will) you call home warranty company and they come out & fix it and you just pay the on call fee!
This is such a great mashup – my kids are obsessed with soup and obviously mac & cheese – yum!
Pretty sure my mouth is watering right now!
Congratulations on your New Home… I've been in mine for 42 years and I'm still working a kink out here and there.. Enjoy it everything will work out. Going to try this soup the first chilly day we have, Looks yummy!!!
Haha, don't feel bad. When we moved in to our house (we just bought our first in April) we discovered the microwave didn't work, the oven only had two working burners and half the control pad didn't work, and the dishwasher leaks when I do a deep clean sanitizing solution. Then, we're in the house for like 3 weeks and our dryer which we bought used off craigslist like 4 1/2 years ago caught on fire. So in the 5 1/2 months we've lived in our house, we've had to buy a new microwave, a new dryer, and a new stove. It happens. But at least I know the new stuff won't be going out anytime soon.
Try switching to powdered detergent. That's what works for us when we had that issue. Also not over filling it.
We moved into our new house on Friday and the storm this morning (southern California) showed me all the places that our roof leaks. Fun times.
Of course this happened when my husband was out of town on a business trip, too. Cheers to home ownership! I'm right there with ya!
This soup sounds amazing! The next time it rains here I am making this soup and enjoying my soon-to-be non-leaky roof!
This soup looks so rich, creamy, and tempting! I could eat this all the time.
If something doesn't break in your new house the first week, it means you're going to be eaten by zombies. Trust me you're not alone! Although sitting by my washing machine with a bowl of popcorn actually sounds kind of fun…I think I have too many children.


text:
using System;
using System.IO;
using System.Text.RegularExpressions;
using CsvToObjectLib;
using Microsoft.VisualStudio.TestTools.UnitTesting;

namespace CsvToObjectTests
{
    public class Car
    {
        public string Brand { get; set; }
        public string Model { get; set; }
        public DateTime ManufactureDate { get; set; }
    }

    public class CarPropertyMapper : ICsvPropertyMapper
    {
        public bool Map(string propName, string csvValue, out object value)
        {
            value = null;
            if (propName != "ManufactureDate") return false;

            csvValue = Regex.Replace(csvValue, @"^(\w+).(\d+)$", @"$1.01-$2");

            value = DateTime.Parse(csvValue);

            return true;
        }
    }

    [TestClass]
    public class UnitTest1
    {
        [TestMethod]
        public void TestMethod1()
        {
            var fn = "testFile.csv";

            var lines = new string[]
            {
                "Brand,Model,Manufacture Date",
                "Opel,Astra,\"Dec,15\"",
                "BMW,116,\"Jun,14\""
            };

            File.WriteAllLines(fn, lines);

            var parser = new CsvObjectParser()
            {
                Separator = ',',
                Mapper = new CarPropertyMapper()
            };

            var task = parser.GetObjects<Car>(new string[] { fn });
            task.Wait();

            File.Delete(fn);
        }
    }
}


text:
Exhibition, Speakers, Catalogue Focus on Rising Seas and Strategies for Adaptation
At a retreat in October 2014, Sunnylands and its partners Prince Albert II of Monaco Foundation and Scripps Institution of Oceanography addressed two of the most pressing issues impacting our planet: rising sea levels and ocean acidification. Now, to extend that effort and raise public awareness of ways people around the world are adapting to these changes, The Annenberg Retreat at Sunnylands and the Annenberg Space for Photography are collaborating on a series of activities.
In this first-time partnership, each organization has taken on a different role. A major photographic exhibition Sink or Swim: Designing for a Sea Change, featuring historic and commissioned photographs showing how people in various storm-tossed locales are adapting–including innovative design solutions–opened in December 2014 at the Annenberg Space for Photography in Los Angeles and will remain on display until May 3, 2015. The exhibition was curated by architecture writer, radio host, and executive producer of KCRW's "DnA: Design and Architecture" Frances Anderton. A small selection of photographs from the exhibition are on display at Sunnylands Center & Gardens through June 2015.
As noted by Geoffrey Cowan, president of The Annenberg Foundation Trust at Sunnylands (2010-2016), "Art. . . provides us with tools to expand our imagination, to visualize the unthinkable, and to start thinking about the barely possible. It can inspire us to create an array of new responses, to imagine fresh possibilities, and to reinvent the future."
Among the photographers featured in the exhibition and at Sunnylands Center is Stephen Wilkes, known for his dramatic photos of New Orleans after Hurricane Katrina. Wilkes will speak at 2:00 pm, February 10, 2015 at the Rancho Mirage Public Library as part of the Sunnylands Speaker Series. He will share his philosophy on creating visuals that tell this story in a unique way and that leave a lasting impression and memory. The photographer documented Hurricane Katrina and will share that work as well as the photographs of Hurricane Sandy taken for Time magazine. He will speak, too, about his most recent work, commissioned by the Annenberg Space for Photography, when he was asked to revisit New Orleans nine years after Katrina, and Oakwood Beach Staten Island, one year after Sandy.
The accompanying exhibition catalogue, published by Sunnylands Press, is for sale in the Sunnylands Gift Shop and at the Annenberg Space for Photography's Skylight Studios retail gallery in Los Angeles. Along with an extensive essay by Frances Anderton and full-color images of many of the photographs in the exhibition, the catalogue contains a reflection on the Sunnylands retreat by Geoffrey Cowan, forewards by HSH Prince Albert II of Monaco and Wallis Annenberg, and a short essay by Margaret Leinen, director of Scripps Institution of Oceanography and Vice Chancellor for Marine Sciences at UC San Diego.
Another Sunnylands Speaker Series event will draw attention to communicating about climate change. On March 24 at 2:00 pm, Dr. Jon Krosnick, a world-recognized expert on the psychology of attitudes, will discuss how language affects public thinking, especially on the topic of climate change. Dr. Krosnick, a professor at Stanford University, has partnered with major national news organizations to study what Americans think about climate change, how communications affect their beliefs, and how language choices can influence public thinking.
Sunnylands Speaker Series events are held at the Rancho Mirage Public Library, 71-100 Highway 111, Rancho Mirage, CA 92270. They are free and open to the public. No reservations or tickets are required although seating is limited.


Outgoing ESNZ high performance director Sarah Dalziell-Clout bows out from her four years in the role with plenty of praise for the team who make up the high performance and performance programmes.
"Behind each and every high performance combination there is a significant team of people and I feel fortunate to have worked with, and learnt a lot from, such a group of experts," says Sarah.
Equestrian Sport chief executive Dana Kirkpatrick said Sarah's contribution to developing the programme into a world class, elite level concept has been exemplary and her skills will be missed by the entire team.
"However, we wish Sarah all the best and know she will continue to follow and support equestrian sport as she is so passionate about it," said Dana.
Sarah, who has been replaced by Simon Bennett, looks back on a period that brought with it, very typically, the highs and lows that only the horse world can deliver.
She's proud of the significant strategic shift that has taken eventing high performance from a rider-focused high performance support programme to a more sustainable system that invests in the wider HP environment.
Initiatives include bringing experts like cross country designer Mike Etherington-Smith and dressage coach Isobel Wessels to New Zealand multiple times have been reflective of this shift.
Similarly, pushes like the HorsePower Project which targets increasing the recognition of owners and sponsors, while attracting new owners and sponsors, has begun to gain real traction.
Sarah has loved seeing the growth of the riders within the eventing performance programme, culminating in success for the senior team at the Oceania Championships in 2017 – she's looking forward to a repeat of that later this year – and the rise of some very exciting combinations who are now on the road to high performance.
Performance leader Jock paid tribute to Sarah's commitment saying she was hugely passionate about our programme and sport, and has made so much positive change. "Only those who have worked with her would truly know just how hard she has worked to deliver the best possible programme for the riders. I appreciate her great leadership and have learnt a lot from working with her. I hope we can continue to drive the programme with the same momentum," he said.
Those sentiments are echoed by eventing dressage coach and former eventing performance leader Penny Castle. "I have enjoyed working with Sarah and seeing the strengths she has brought to what we have been aiming to achieve. She believed in what we were doing in New Zealand and always backed us in producing riders and horses to step up into the programme in the UK," said Penny.


text:
Q: What do robot parts do? After creating the metalwork station, I am able to construct various robot parts, such as legs, arms, and chest parts.  I cannot yet make a head (no artificial brain), and I cannot make the robot crafting station, but I am quite curious what will happen if I try to construct this robot.
What do these robot parts do, and is it a good idea to use my resources to build a robot?

A: When you have built the full Inactive Robot, you can place it on the surface of a planet and activate it to fight a boss enemy. On being defeated, that boss will drop a Processor item, needed to make a more advanced crafting table, which itself is then used to create a better star map, and proceed to the next sector.
In short, yes, you will eventually need to make the robot to keep advancing. But, you may not want to make it too immediate a priority, as the boss may be difficult to defeat if you've only just unlocked the Metalwork Station.

redpajama_set_name: RedPajamaStackExchange


Looking for a 2 Bedroom Villa with Shaded Afternoon Patio? Well, look no further! 77 Torrey Pines has the shaded afternoon patio and more - very nicely furnished and offering the larger 2 bedroom square footage of approximately 1,127 sf. HOA Fee includes Lawn Care and Landscaping, Water Sprinkler Water, Roof Maintenance, and Exterior Building Insurance. Owner is responsible for their utilities and interior insurance. 77 Torrey Pines also has a long screened porch and very private. Also very close to the Swimming Pool on the corner of Torrey Pines & Augusta Dr.......or you can also enjoy the Club House, Gym, Main Swimming Pool, or Tennis, or any of the many Social Activities. Be sure to check out the Oak Tree Restaurant & Bar.


text:
//  SFExtension
//  https://github.com/paintingStyle/SFExtension.git
//  Copyright © paintingStyle. All rights reserved.

#import <Foundation/Foundation.h>

@interface NSObject (SFExtension)

//类名
- (NSString *)className;
+ (NSString *)className;
//父类名称
- (NSString *)superClassName;
+ (NSString *)superClassName;

//实例属性字典
-(NSDictionary *)propertyDictionary;

//属性名称列表
- (NSArray*)propertyKeys;
+ (NSArray *)propertyKeys;

//属性详细信息列表
- (NSArray *)propertiesInfo;
+ (NSArray *)propertiesInfo;

//格式化后的属性列表
+ (NSArray *)propertiesWithCodeFormat;

//方法列表
-(NSArray*)methodList;
+(NSArray*)methodList;

-(NSArray*)methodListInfo;

//创建并返回一个指向所有已注册类的指针列表
+ (NSArray *)registedClassList;
//实例变量
+ (NSArray *)instanceVariable;

//协议列表
-(NSDictionary *)protocolList;
+ (NSDictionary *)protocolList;

- (BOOL)hasPropertyForKey:(NSString*)key;
- (BOOL)hasIvarForKey:(NSString*)key;

#pragma mark - Swap method (Swizzling)

/**
 * 交换两个实例方法的实现.

 * @param originalSel   Selector 1.
 * @param newSel        Selector 2.
 * @return              YES if swizzling succeed; otherwise, NO.
 */
+ (BOOL)swizzleInstanceMethod:(SEL)originalSel with:(SEL)newSel;

/**
 * 交换类方法的实现

 * @param originalSel   Selector 1.
 * @param newSel        Selector 2.
 * @return              YES if swizzling succeed; otherwise, NO.
 */
+ (BOOL)swizzleClassMethod:(SEL)originalSel with:(SEL)newSel;

@end


Your foreign relative requires an immigrant visa to enter the United States. You know that s/he is eligible to apply.
What is the Timeline to Apply for and Obtain an Immigrant Visa?
Once the relative petition is filed, the USCIS issues a receipt notice to the petitioner (U.S. citizen or permanent resident) and attorney. Since each relative petition differs in terms of complexity, the decision time can vary. Once approved, the USCIS issues an approval notice to the petitioner and attorney. The approved relative petition is then forwarded to the National Visa Center (NVC) for the second step in the process.
Once the approved relative petition is received, the NVC performs a background check of your foreign relative, collects immigrant visa and affidavit of support fees and documents (sample documents are listed here), processes the immigrant visa application and provides instruction regarding the interview and the required medical examination. After processing is complete, the NVC schedules an interview and forwards the relative petition, immigrant visa application and documents to the United States embassy or consulate nearest your foreign relative's residence.
* The Immigration and Nationality Act (INA) limits the number of family based immigrant visas that are issued each year based on a preference category. Each preference category is assigned a number of immigrant visas. In addition, there is a limit to the percentage of immigrant visas that can be allotted to each country in a year. Since the demand for immigrant visas is higher than the limited number and greater for some countries, an immigrant visa 'waiting list' forms. As such, your foreign relative's preference category and country of origin will determine the time the relative petition will remain at the NVC until an immigrant visa number becomes available. The wait time can be years.
At the interview, the consular officer will verify that all required documentation (sample documents are listed here) has been provided. Second, and more importantly, the consular officer will question your foreign relative in detail with respect to the specifics of family relationship in order to determine its legitimacy.
Assuming that the consular officer is satisfied, the immigrant visa application is approved and an immigrant visa is placed in your foreign relative's passport. The visa will be valid for 6 months. The United States embassy or consulate will also provide your foreign relative with a sealed envelope that contains the approved petition, applications and documentation. Before departing for the United States, each person that received an immigrant visa must pay a USCIS Immigrant Fee online.
Upon issuance of the immigrant visas, your foreign relative will enter the United States within 6 months. Upon entry into the United States, your foreign relative will give the sealed envelope to the Customs and Border Protection (CBP) officer. The CBP officer will stamp your foreign relative's passport. This signifies entry as an immigrant.
After entry as an immigrant, your foreign relative will receive a lawful permanent resident card. The permanent resident card will be valid for 10 years.


text:
Q: Regex for SQL Query Hello together I have the following problem:
I have a long list of SQL queries which I would like to adapt to one of my changes. Finally, I have a renaming problem and I'm afraid I want to solve it more complicated than expected.
The query looks like this:
INSERT member (member, prename, name, street, postalcode, town, tel1, tel2, fax, bem, anrede, salutation, email, name2, name3, association, project) VALUES (2005, N'John', N'Doe', N'Street 4711', N'1234', N'Town', N'1234-5678', N'1234-5678', N'1234-5678', N'Leader', NULL, N'Dear Mr. Doe', N'a@b.com', N'This is the text i want to delete', N'Name2', N'Name3', NULL, NULL);

In the "Insert" there was another column which I removed (which I did simply via Notepad++ by typing the search term - "example, " - and replaced it with an empty field. Only the following entry in Values I can't get out using this method, because the text varies here. So far I have only worked with the text file in which I adjusted the list of queries.
So as you can see there is one more entry in Values than in the insertions (there was another column here, but it was removed by my change).
It is the entry after the email address. I would like to remove this including the comma (N'This is the text i want to delete',).
My idea was to form a group and say that the 14th digit after the comma should be removed. However, even after research I do not know how to realize this.
I thought it could look like this (tried in https://regex101.com/)
VALUES\s?\((,) something here
Is this even the right approach or is there another method? I only knew Regex to solve this problem, because of course the values look different here.
And how can I finally use the regex to get the queries adapted (because the queries are local to my computer and not yet included in the code).

Short summary:
Change the query from
VALUES (... test5, test6, test7 ...)

To
VALUES (... test5, test7 ...)

A: As per my comment, you could use find/replace, where you search for:
(\bVALUES +\((?:[^,]+,){13})[^,]+,

And replace with $1
See the online demo

*

*( - Open 1st capture group.

*

*\bValues +\( - Match a word-boundary, literally 'VALUES', followed by at least a single space and a literal open paranthesis.

*(?: - Open non-capturing group.

*

*[^,]+, - Match anything but a comma at least once followed by a comma.

*){13} - Close non-capture group and repeat it 13 times.

*) - Close 1st capture group.

*[^,]+, - Match anything but a comma at least once followed by a comma.

A: You may use the following to remove / replace the value you need:
Find What: \bVALUES\s*\((\s*(?:N'[^']*'|\w+))(?:,(?1)){12}\K,(?1)
Replace With: (empty string, or whatever value you need)
See the regex demo
Details

*

*\bVALUES - whole word VALUES

*\s* - 0+ whitespaces

*\( - a (

*(\s*(?:N'[^']*'|\w+)) - Group 1: 0+ whitespaces and then either N' followed with any 0 or more chars other than ' and then a ', or 1+ word chars

*(?:,(?1)){12} -  twelve repetitions of , followed with the Group 1 pattern

*\K - match reset operator that discards the text matched so far from the match memory buffer

*, - a comma

*(?1) - Group 1 pattern.

Settings screen:


Find your proper sequence with this simple golf drill.
One of the most common mistakes a golfer will make is in their sequencing.
This means that once they get to the top of their backswing, they pull their arms and club down first, which can lead to many more mishits.
This drill can help your body understand the proper sequence from the top of the backswing all the way to the follow-through.


For the past ten years, I have been proud to have worked alongside the Dreamcatcher Foundation [South Africa] as one of their partners. My regular visits to South Africa have been spent coaching and empowering township entrepreneurs in micro-business skills and working on individual's personal development. These skills over the years have proved to be sustainable in terms of enabling them to grow their businesses and support their own families.
Rosie We first met with Rosie ten years ago when she was unable to walk and in desperate need of two hip replacements. Fast forward ten years, due to Dreamcatcher's intervention and regular coaching support, she has now been able to have two new hip replacement operations and has made a good recovery. Rosie is now ready to build her business in being a Kamamma for Dreamcatcher and start to live her life again.
Muriel is only in her 40s but had a stroke and lost confidence in her ability to lead an independent life and head up her household of children and grandchildren. She was always known as Dreamcatcher's 'singing bird' but even her singing became a casualty of her low self-esteem. I have visited Muriel over the past years and worked with her on personal development issues. She has made good progress is now keen to continue her role in Dreamcatcher as a valued Kamamma.
Antoinette is a seamstress and has now opened up her own sewing business which is going from strength to strength. She has responded well to Dreamcatcher's training showing her how to grow her business and the one to one business coaching support she has received from me has enabled her to grow personally as well as professionally.
Mary's House of Hope and Dreams: Mary and David are a dedicated couple who look after 15 abandoned children in their home. Their commitment and tireless dedication to take children off the streets and educate them is a role model to us all. They have created a community of love and support and the children are examples of what is given unconditionally to them. I have been able to support this dedicated couple by providing schoolbooks, beds and clothing for the children.


Why brands should start investing in this media.
Gone is the set top box, and cable operators will meet a similar fate soon if they don't align with current consumption trends. These days, users (especially Millennials) are turning to other screens to watch video content. This new fad is referred to in any number of ways: cord-cutters, streamers, et al. TV dollars are still taking up the lion's share of advertising budgets, but digital video has been making its own case for a substantial piece of the ad budget pie, purely based on scale and demand.
According to eMarketer total Mobile ad spending already surpassed desktop in 2015, and it's only a matter of time that this growth reaches levels of TV, at the sacrifice of spending ad dollars against the most traditional advertising medium in history. In short, one can think of it as the oft-coveted GRP is moving from Television to Smartphones.
According to Google, Nielsen recently found that its YouTube service reached more people between the ages of 18 and 49 on mobile devices alone than any TV network in December of last year, while comScore found that 44% of YouTube viewers in that age bracket don't watch prime-time broadcast TV in an average week. In large part, social sharing functionality is driving this and eMarketer predicts that 71% of smartphone users will regularly be watching video on their devices during calendar year 2016.
Not only should content be tailored to viewing on other devices, in relation to screen size, time spent on site/app and other variables at play, but it's crucial that marketers shift their advertisements to be video-centric in nature to fit the mold. This is a function of attention spans having decreased dramatically over time and to put it plainly, the thirst for more content. Perhaps its delivering additional B-roll footage to someone who just watched a show on Netflix, or teasing a movie trailer one might be interested in based on previous viewing habits.
Whatever it may be, the efficacy of banner advertising is starting to wane, while advertisers are more interested in delivering memorable and engaging user experiences that deliver positive results on brand health metrics. As it turns out, video seems to leave a lasting image a bit more so than a 300×50 banner ad.
Mainstream media outlets have noticed this change in how consumers consume and made necessary adjustments at their flagships. For some time now, when we visit www.cnn.com, the main headline is followed by a video, not an article. We're in an age of instant gratification and most users would rather watch a :60s video clip (while being at the mercy of a :15s pre roll, hooray ads!) as opposed to spending an extra few minutes to read a full article.


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Bangladesh has been a traditional transit route to Pakistan for militants ince 1995, reveals one of the conspirators of IC-814 hijacking.
Some religious schools double up as shelter places for terrorists in Bangladesh, which has been a traditional transit route to Pakistan for them since 1995, reveals one of the conspirators of IC-814 hijacking.
Abdul Latif, who was arrested by the CBI, has said in his statement before the investigating agency that he had gone to Dhaka way back in 1995 where he contacted Faizullah, a militant who was working as the principal of a madrasa (religious school) in Mohamadpur.
Giving a complete insight into the entire hijacking conspiracy, Latif, whose statement has been submitted before the sessions court in Patiala, said during his stay in the madrasa, he had met two more Pakistani militants -- Akhtar and Abdul Rehman, who were injured while "fighting" in Kashmir and were on their way back to Pakistan.
Latif, alongwith the two militants, left for Karachi by a Pakistan international flight and upon his arrival in the port city, was sent for training to Khost in Afghanistan, the statement said.


This is such a comfortable home. It has a bright and cheerful character. The living room area has a ceiling that goes up to a peak making it feel roomy. It has an eat-in kitchen, dishwasher and a counter that wraps around to form a divider to the living room and is a great work area. The slider off to the Florida room is great if you want to use it for another sleeping area for your guests or another TV area. The master bedroom has room to spare and its own half bath. This home comes furnished and ready to move in. Better hurry, this won't last. This is cottage style living in Clearwaters premiere 55+ waterfront community. There are endless activities to get to meet your neighbors cards, a wonderful art group, golf groups, bowling, shuffleboard, dinners, dances or head to the pool or hot tub. A low $320. maintenance fee pays for water, sewer, trash pickup, lawn cutting and on-site management. Sorry no dogs are allowed.
Additional Water Information This Home is Not On The Water But it Shares With The Community - A Boat Launch Fishing Piers And Wonderful Water Views Form Everywhere in The Park!
Additional Lease Restrictions Tenant Must Make Application To The Park Office.


New York City kids are out of school, and NYC Parks has plenty of fun activities to keep them busy. Join us for FREE "Kids Week" programming across the five boroughs with indoor and outdoor events led by Parks' Urban Park Rangers.
Use a compass and map to navigate your way around Pelham Bay Park and find hidden objects.
Explore the sea shore and look out for diverse wildlife as you hike.
Look for signs of wildlife and identify trees on this walk with Urban Park Rangers.
Learn about campfire safety with the guidance of our Urban Park Rangers and sing along to classic campfire songs.
Join the Urban Park Rangers for an afternoon of learning and playing fun water games.
Hit the bull's eye with our Urban Park Rangers and try your hand at the art of archery.
For a complete list of events, please visit our events calendar on our website.


Fishing can be a great hobby for those who like to spend time outdoors. Whether alone, with your family, or with some friends, you can learn how to fish and have a great time. Read the custom soft plastic crappie baits tips in this article so you can learn how to fish like a professional!


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The 1936 Mercer Bears football team was an American football team that represented Mercer University as a member of both the Dixie Conference and the Southern Intercollegiate Athletic Association (SIAA) during the 1936 college football season. In their eighth year under head coach Lake Russell, the team compiled a 3–6–1 record.

Schedule

References

Mercer
Mercer
Mercer Bears football seasons
Mercer Bears football