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Research has changed our world. It is the bedrock of improving healthcare systems, treatments and outcomes. Research has enabled society to eradicate diseases and change lives. Medical Research is the search for understanding. Understanding leads to solutions. Solutions lead to cures
Advances in health research have led to so many transformations in healthcare, many of which we now take for granted. We research for the future and generations that follow us in the hope that they will too 'take for granted' a transformation to what may once have been a life altering or limiting diagnosis.
To learn more about the types of Research supported by the Research Foundation, please click on your area of interest below.
The Eithne Walls Research Meeting 16th June 2022
Held annually, the Eithne Walls Research Meeting provides a forum for trainee doctors to present their research and clinical study work to their peers. The meeting is held in memory of Dr. Eithne Walls, a Senior House Officer of Ophthalmology in the Royal Victoria Eye and Ear Foundation who was a passenger on the ill-fated flight A447 that disappeared over the Atlantic on 1st June 2009.
The meeting is an opportunity for trainee doctors to present their work to their peers and enhance their experience in undertaking clinical learning and research, crucial to continuing our work to advance education and development.
Young doctors who have taken part in the Eithne Walls Research Meeting have gone on to be part of crucial research projects bringing us closer to developing new treatments for conditions that cause blindness and deafness and broadening our understanding of how to treat and prevent eye and ear disease.
The Research Foundation offers trainees who participate the opportunity to win 1 of 3 awards for the best presentation:
Ophthalmology: The Eithne Walls Medal
Otolaryngology: The Aongus Curran Medal
Ophthalmology, Otolaryngology & Anaesthetics: The Research Foundation Clinical Prize for Clinical Achievement
The Aongus Curran Medal commemorates our colleague Professor Aongus Curran, the eminent ENT Surgeon and Professor of Otorhinolaryngology who passed away suddenly in August 2016.
Spotlight on Research – Dry Eye Disease and Micro RNA
We are delighted to share this insight into the research being carried out by Dr. Emily Greenan, supported by the Research Foundation.
We believe research is the key to creating real change and improvements in peoples lives – by understanding the cause, we can prevent and ultimately cure.
Dr. Greenan researches Dry Eye Disease which affects between 5% and 50% percent of the world's population. In particular, Dr. Greenan's research focuses on Primary Sjogren's Syndrome, a condition which causes dry eyes and mouth.
We hope you will enjoy this video and if you have any questions or would like to support or know more about our research, please do not hesitate to contact us.
Watch Now – Dry Eye Disease and Micro RNA, Dr. Emily Greenan
Genetics is the study of genes and heredity. As our understanding of genetics and hereditary conditions develops, the potential for preventative treatments is exponentially expanded and catapults us to a new level of perception on how and why conditions are passed on through families.
The Research Foundation has a long standing interest in inherited retinal degenerations since its inception. The Foundation is the premier centre in Ireland for the clinical characterisation of patients with a variety of inherited diseases such as Retinitis Pigmentosa(RP), Choroideraemia, Stargardts Disease and X-Linked Retinoschisis, amongst many others. Patients are referred from Ophthalmology units throughout the country for these highly specialised investigations.
At present, patients with inherited retinal degenerations face inexorable loss of vision, in many cases resulting in total blindness. However, as a result of the molecular genetic advances with which the Foundation has been intimately involved, realistic prospects now exist to give hope that treatments will become available in the foreseeable future. At the Foundation, we aim to continue to be at the forefront of research which will eventually result in the development of sight-saving treatments for these patients. The Foundation has collaborated closely with the Ocular Genetics Unit at Trinity College Dublin for Three decades in the genetic characterisation of patients attending the Foundation. This collaboration has resulted in the identification of novel disease causing genes responsible for some of these inherited retinopathies.
Amongst the pioneering discoveries resulting from this collaboration were the identification of Rhodopsin, the first disease associated gene ever identified in any form of RP and now known to be the most frequent case of autosomal dominant forms of RP, the first reporting of a mutation in the Peripherin/RDS gene in a form of autosomal dominant ROP, the first implication of the mitochondrial second serine transfer RNA gene (MTTS2) in patients with RP and hearing loss, and the first documentation of a dominantly acting mutation in the RPE65 gene in a late onset form of RP. None of these discoveries would have been possible without the generous cooperation of patients ascertained and clinically investigated at the Foundation.
Researchers at the Foundation continue this effort with the goal of achieving the core aim of the Foundation, namely, 'development of new treatments for eye and eye conditions which will 'eliminate hearing and sight loss'.
Age-related macular degeneration is one of the most common causes of visual impairment in the Irish population. Although many risk factors for the condition have been identified, recent research has highlighted the significance of genetic factors in increasing the risk of an individual developing this disease. A large-scale study into the genetics of AMD is presently underway at the Foundation to characterise the importance of genetic risk factors in the Irish AMD population.
Retinitis Pigmentosa (RP)ADRP with Choroidal Involvement associated with Asp477gly Mutation within the Rpe65 Gene
In a collaborative research effort between the Research Foundation at the Royal Victoria Eye and Ear Hospital and the Ocular Genetics Unit at Trinity College Dublin investigators identified a new gene responsible for a form of autosomal dominant Retinitis Pigmentosa. The results were published in October 2011. Linkage testing using Affymetrix 6.0 SNP Arrays mapped the disease locus in TCD-G, an Irish family with autosomal dominant retinitis pigmentosa (adRP) ascertained and clinically characterized at the Foundation to an 8.8 Mb region on 1p31. Candidate gene and exome sequencing resulted in the identification of an Asp477Gly mutation in exon 13 of the RPE65 gene tracking with the disease in TCD-G. The Asp477Gly mutation was not present in Irish controls, but was found in a second Irish family identified at the Foundation, provisionally diagnosed with Choroideraemia, but in whom no Choroideraemia gene mutation had been found. Mutations in RPE65 are a known cause of recessive Leber congenital amaurosis (LCA) and recessive RP, but no dominant mutations have been reported. This important paper (A dominant mutation in RPE65 identified by whole-exome sequencing causes retinitis pigmentosa with choroidal involvement. Bowne SJ, Humphries MM, Sullivan LS, Kenna PF, et. al. Eur J Hum Genet. 2011 Oct;19(10):1074-81. doi: 10.1038/ejhg.2011.86. Epub 2011 Jun 8) documented for the first time a dominantly acting mutation in this gene in 2 families with a clinical picture somewhat reminiscent of Choroideraemia. Approximately 20% of patients with a diagnosis of Choroideraemia do not have mutations in the X-linked gene for Choroideraemia. It is likely that mutations in RPE65 may be responsible for the disease in these patients.
Gene therapy for LCA patients with RPE65 mutations has shown great promise, raising the possibility of related therapies for dominant-acting mutations in this gene.
Registry of Irish Patients with Leber Congenital Amaurosis and Early Onset Severe Retinal DystrophyWellcome Trust – HRB Centre for Clinical Research, Molecular Medicine Ireland, P. Kenna (RVEEH) , M. Cahill (RVEEH), D. Keegan (MMH), I. Flitcroft (MMH).This collaborative research co-ordinated by Mr. P. Kenna of the Research Foundation at the Eye and Ear Hospital and Mr. David Keegan of the Mater Misericordiae Hospital aims to identify Irish patients with Leber Congenital Amaurosis or Early Onset Severe Retinal Dystrophy (EOSRD), conditions in which gene mutations in the RPE65 gene have been identified. The aim is to document the incidence of these rare inherited disorders in the Irish population and to identify those individuals who might benefit from the encouraging results of the on-going clinical trials of gene therapy in these conditions.
Genetic Characterisation of a population of Irish Retinal degeneration patientsThe study, funded by the Health Research Board of Ireland aims to analyse the DNA of a cohort of Irish patients with a variety of inherited retinal degenerations using next generation gene sequencing technology. This is a collaborative effort between Mr. P. Kenna of the Research Foundation, The Royal Victoria Eye and Ear Hospital and Prof. G. Jane Farrar at the Genetics Department, Trinity College Dublin.
As a result of this work a Phase 1b trial of an orally delivered 9-cis retinal analogue involving Irish patients with this condition and sponsored by QLT Inc. of Canada has just commenced. This is the first gene-informed treatment trial for any form of autosomal dominant Retinitis Pigmentosa and further highlights the importance of the long-standing work of the Foundation in this area.
Patients with a variety of inherited retinal degenerations who have been clinically characterised at the Foundation have been recruited over the past 2 years into a research project funded by the Health Research Board for next generation genome sequencing. This ambitious project will hopefully result in the identification of disease-associated gene mutations in these patients. While the study is designed to give a picture of the spectrum of genes causing inherited retinopathies in a cohort of Irish patients the results will be of value to the participants and allow them to consider participating in future gene-based treatment trials. Undoubtedly, over the next 5 to 10 years, as a result of the progress in elucidating the genetic basis of many of these currently untreatable disorders, treatment options are likely to become available. The Foundation is proud of its contribution over many years to this pioneering work.
Mr. Eoin Hanney, an Irish clinical genetics student at the University of Wales, is conducting a survey of patients attending the Foundation with Retinitis Pigmentosa into their experiences and attitudes to genetic testing. This important study will hopefully influence the development of future genetic testing services in Ireland. This is undoubtedly going to become a major clinical need for Irish patients as more treatment options, many based on knowledge of the disease causing gene, become available.
The Retina is the thin layer of cells lining the back of the eye. These cells are light sensitive, sensing light as it hits the eye. The retina sends signals via the optic nerve to the brain, resulting in visual images.
There are multiple conditions of the retina consequently, research is accordingly diverse.
The Research Foundation has participated as the primary site for a number of important clinical trials. Amongst these has been the study of treatments for retinal vein occlusion – the blockage of the small veins of the retina. Retinal vein occlusion and pressure can cause blurred vision or even sudden permanent blindness according to levels of severity. The Research Foundation has investigated the use of anti-VEGF intravitreal injections for the treatment of retinal diseases. The use of this therapy has been found to be effective in treating symptoms of age related wet macular degeneration, diabetic macular oedema as well as retinal vein occlusions.
Objective three-steps grading of digital fundus photographs of diabetic retinopathy This project is using objective three-step grading of fundus photographs of patients with diabetic retinopathy. 450 hospital-based patients have been screened to date. The three-step process increases the quality of the grading of the screening program. A quality component has been the use of OCT to detect diabetic macular oedema. This project will be expanded in 2012 to include 2 primary practices located in Ranelagh and Churchtown. It is hoped that some of the lessons learned from this programme would be adapted by the proposed National Screening Programme which is scheduled to start by the HSE towards the end of 2012.
RETAIN Study This is a phase 3 clinical trial investigating the use of Ranibizumab (anti-VEGF medication) for the treatment of macular oedema. The Research Foundation is the principal investigating site for the study. The project started in January 2011 and will continue until January 2013. 5 patients have enrolled in the study which requires monthly visits and extensive investigation of each patient.
BRIGHTER Study This is a phase 3 clinical trial examining the use of Ranibizumab in the treatment of macular oedema secondary to branch retinal vein occlusion. The Research Foundation will be the principal investigator on site for this trial in Ireland. It is proposed that recruitment for the study will commence in August 2012.
CRYSTAL Study This is a phase 3 clinical trial examining the use of Ranibizumab in the treatment of macular oedema secondary to central retinal vein occlusion. The Research Foundation will be the principal investigator on site for this trial in Ireland. It is proposed that recruitment for the study will commence in August 2012.
Oncology / Pathology
Collaboration between the Pathology and Oncology services at the Royal Victoria Eye & Ear Hospital and Dublin City University looks at potential prognostic biomarkers in eye cancer. The pathology and ocular oncology units at Royal Victoria Eye & Ear Hospital are also working closely with the National Institute for Cellular Biotechnology NICBI on a Research Foundation supported research programme in identifying specific proteins in patients with
eye melanoma that help to predict the spread of cancer outside the eye, with the aim of improving long term patient survival.
Continuing developments in this important area of research are extremely impactful – influencing and informing our management and treatment of these conditions.
Uveal Melanoma in Ireland
Caroline Baily, Valerie O'Neill, Mary Dunne, Moya Cunningham, Giuseppe Gullo, Susan Kennedy,Paul M. Walsh, Sandra Deady, Noel Horgan
Proteomic analysis of tumours and vitreous fluid from uveal melanoma
P.Ramasamy (MD Study), Prof C.Murphy, Mr N.Horgan, Dr P.Meleady, M.Clynes
Establishment of a database and tissue microarray bank of 500 archived uveal melanoma tumours
funded by SFI grant to the consortium Molecular Therapeutics for Cancer, in association with Paul Moriarty and Mr Noel Horgan. In collaboration with Professor Clynes's Research Group (DCU) and with Professor Beatty's Group (WTI), Mr Moriarty and Mr Horgan are conducting a study of uveal melanoma proteomics funded by the Research Foundation and donation from Professor Beatty.
A collaboration with Dr Brian Hennessey, RCSI on molecular sequencing of head and neck tumours
funded by SFI grant to the consortium Molecular Therapeutics for Cancer.
Ocular Immunology, Inflammation & Corneal Research
The cornea is the clear window at the front of the eye. It forms a protective layer and has an important function in focusing vision and allowing light enter the eye. Ocular Immunology is the study of how the eyes immunity processes and mechanisms contribute to disease and how they can be manipulated to prevent and fight disease.
The Research Foundation supports long term collaboration between the ocular inflammation/cornea service of the Royal Victoria Eye & Ear Hospital, the National Institute for Cellular Biotechnology (NICB) at Dublin City University, the Department of Immunology at the Royal College of Surgeons Ireland and the Department of Rheumatology at St Vincent's University Hospital. This collaboration brings together clinical and scientific skills from a range of disciplines that are helping to improve our understanding of a number of inflammatory eye conditions and corneal diseases. The wide ranging research in these areas of specialty continues to significantly advance our scientific and clinical knowledge – benefiting professionals, and patients.
Profiling microRNA expresson and Toll-like receptor responses in patients with Sjögren's syndrome, graft versus host disease and other causes of ocular surface inflammation Professor Conor Murphy, Professor of Ophthalmology, RCSI & RVEEH
Pathogenic cytokines in temporal artery explants from patients with giant cell arteritis Professor Conor Murphy, Professor of Ophthalmology, RCSI & RVEEH; Prof Eamonn Molloy, St Vincent's University Hospital.
Adverse immune signatures and their prevention in corneal transplantation (VISICORT)
Professor Conor Murphy, RCSI Professor of Ophthalmology, RVEEH.
Impact of Humira therapy on ocular inflammation, selected health care resource utilization and patient reported outcomes in patients with active non-infectious intermediate, posterior and panuveitis in routine clinical practice –HOPE Study. Professor Conor Murphy, Professor of Ophthalmology & Consultant Ophthalmic Surgeon, RVEEH & RCSI
Analysing the expression and role of Micro RNA in patients with uveitis
Prof Conor Murphy, Professor of Ophthalmology & Consultant Ophthalmic Surgeon, RVEEH & RCSI
Impact of anterior uveitis patients: 5 year prognosis from the DUET study
Prof Conor Murphy, Professor of Ophthalmology & Consultant Ophthalmic Surgeon, RCSI & RVEEH
Targeting ocular inflammation in dry eye disease with novel microRNA-based therapeutics
Development and implementation of the National Uveitis Registry
Professor Conor Murphy, Professor of Ophthalmology, RCSI, RVEEH
Effect of IKERVIS on cytokine and microRNA profile at the ocular surface in severe keratitis due to dry eye disease
Herpes simplex keratitis research
Herpes simplex keratitis (HSK) represents the single most important inflammatory disease of the cornea with respect to its impact on vision and health related quality of life. It is characterised by repeated episodes of inflammation in the cornea, the clear window at the front of the eye, which leads to corneal scarring and, in many cases, loss of vision. It is caused by the common cold sore virus, known as Herpes Simplex Virus type 1. Our research into this condition aims to improve our understanding of how the herpes virus interacts with our immune system, particularly our innate immunity which is our first line of defense. By improving our understanding of this interaction, we hope to identify new targets for treatments of this disease and improve the outlook for sufferers of HSK.
Evasion of the innate immune response by herpes simplex virus in the cornea: molecular mechanisms mediating interferon down regulation and virus survival
Effect of corneal Herpes Simplex Virus-1 infection on Toll-Like Receptor expression in human peripheral blood mononuclear cells
Investigators: Conor Murphy, David Shahnazaryan, Ciaran de Chaumont, Con Malone, Joan Ni Gabhann and Caroline Jefferies.
Affiliations: Royal Victoria Eye and Ear Hospital and Royal College of Surgeons in Ireland
Improving outcomes in giant cell arteritis through clinical collaboration
Increasing diagnostic accuracy in GCA through imaging
Blood Vessel Instability and Oxidative Damage in Giant Cell Arteritis
Investigating pro-inflammatory mechanisms of GCA using an ex-vivo temporal artery culture model
Investigators: Conor Murphy, Eamonn Molloy, Ursula Fearon, Douglas Veale, Geraldine McCarthy, Lorraine O'Neill and Jim Meaney.
Affiliations: Royal Victoria Eye and Ear Hospital, Royal College of Surgeons In Ireland, St Vincent's University Hospital, University College Dublin, St James' Hospital and the Mater Misericordiae Hospital.
Primary Sjögren's Syndrome Research
Primary Sjögren's Syndrome (pSS) is an autoimmune disease that destroys the specialised secretary glands that produce saliva and tears, causing dry eyes and dry mouth as well as generalized symptoms of aches, pains and lethargy. There is currently no cure for pSS and the exact cause is unknown. In this study we are expanding our understanding of this disease at a molecular level by investigating the role of toll-like receptors on blood cells from patients with pSS, as well as minor salivary gland biopsies (when taken for diagnostic purposes), tear samples and ocular surface washings. This study is being funded jointly by the Health Research Board (HRB) and the RVEEH Research Foundation.
Profiling Toll-like receptor responses in patients with primary Sjögren's syndrome
Investigators: Conor Murphy, Caroline Jefferies, Con Timon, Eamonn Molloy, Joan Ni Gabhann.
Affiliations: Royal Victoria Eye and Ear Hospital, St Vincent's University Hospital and Royal College of Surgeons in Ireland.
Anterior uveitis and spondylarthropathy researchAcute anterior uveitis (AAU) is characterised by the acute onset of inflammation in the front compartment of the eye, leading to pain, light sensitivity and blurred vision. It is a common reason for presentation to ophthalmic emergency departments. In approximately half of cases there is an identifiable systemic disease, most commonly the seronegative spondyolarthropathies (SpA). This is a group of inflammatory joint diseases that predominantly affect the spine but have many other manifestations including skin and bowel problems.
This collaboration with St. Vincent's Unversity Hospital Department of Rheumatology has led to the development of an assessment algorithm called the Dublin Uveitis Evaluation Tool (DUET) that enables the earlier recognition of SpA. With early detection come early and more effective treatment and disease control, and hence better quality of life. Our laboratory studies on the causative mechanisms of AAU are also providing us with some fascinating insights into the disease.
Validation of the Dublin Uveitis Evaluation Tool (DUET), a new algorithm for the detection of undiagnosed spondylarthropathies in patients presenting with acute anterior uveitis in a primary care ophthalmology setting.
To investigate the role of regulatory microRNA and dendritic cell function in the pathogenesis of acute anterior uveitis
Prospective evaluation of vision and health-related quality of life in patients with acute anterior uveitis.
Peripheral blood mononuclear cell activation status and functional characteristics in patients with acute anterior uveitis.
Investigators: Conor Murphy, Micheal O'Rourke, Pathma Ramasamy, Muhammad Haroon, Mary Connolly, Douglas Veale, Ursula Fearon, and Oliver Fitzgerald.
Affiliations: Royal Victoria Eye and Ear Hospital, Royal College of Surgeons In Ireland, St Vincent's University Hospital, and University College Dublin
Genetic analysis of patients with congenital hereditary endothelial corneal dystrophy (CHED)CHED is a very rare inherited disease that manifests early in life with clouding of the front window of the eye, the cornea, as well as poor vision and nystagmus (wobbly eyes). It typically presents between the age of 2 and 5 years and causes lifelong bilateral blindness. In previous work, Dr Collette Hand, Lecturer in Genetics at UCC, located the abnormal gene causing CHED to chromosome 20. Since then, the affected gene has been identified and called SCL4A11. A large number of mutations in this gene have been described in different populations. In this study, we wish to identify the nature of the mutation in the SCL4A11 gene in a large Irish family with the condition.
Investigators: Conor Murphy, Mairide McGuire, Collette Hand.
Affiliations: Royal Victoria Eye and Ear Hospital, Royal College of Surgeons In Ireland, and the Department of Molecular Genetics, University College Cork.
Corneal Tissue Engineering Research
Gene expression profile of cultured limbal-cornea epithelial stem cells and cultured limbal fibroblast cells
The role of cell culture set up in the growth of cultured limbal-cornea epithelial stem cells.
Investigators: William Power, Conor Murphy, Martin Clynes, Finbarr O'Sullivan & Clare Gallagher
Affiliations: Royal Victoria Eye and Ear Hospital, Royal College of Surgeons In Ireland
Amin M, Ali R, Kennedy S, Timon C. Ear Nose Throat J (2012) Inflammatory myofibroblastic tumor of the nose and paranasal sinuses masquerading as a malignancy, 91 (5): E1-3
Browne B.C, Eustace A.J, Kennedy S, O'Brien N.A, Pedersen K, McDermott M.S.J. Larkin A.S.M, Ballott J, Mahgoub T, Sclafani F, Madden S, Kennedy J, Duffy M.J, Crown J, O'Donovan N, (2012) Evaluation of IGF1R and phosphorylated IGF1R as targets in HER2-positive breast cancer cell lines and tumours, Breast Can Res Treat, 136(3):717-27
Chadderton N, Palfi A, Millington-Ward S, Gobbo O, Overlack N, Carrigan M, O'Reilly M, Campbell M, Ehrhardt C, Wolfrum U, Humphries P, Kenna P.F, Farrar, G.F. (2012) Intravitreal delivery of AAV-NDI1 provides functional benefit in a murine model of Leber hereditary optic neuropathy. Eur J Hum Genet. 2012 Jun 6. doi:10.1038/ejhg.2012.112. [Epub ahead of print] PubMed PMID: 22669418.
Doyle SL, Campbell M, Ozaki E, Salomon RG, Mori A, Kenna P.F, Farrar G.J, Kiang A.S, Humphries M.M, Lavelle E.C, O'Neill L.A, Hollyfield J.G, Humphries P (2012) NLRP3 has aprotective role in age-related macular degeneration through the induction of IL-18 by drusen components. Nat Med. 2012 May;18(5):791-8. PubMed PMID: 22484808.
Germano S, Kennedy S, Rani S, Gleeson G, Clynes M, Doolan P, McDonnell S, Hughes L, Crown J, O'Driscoll L, (2012) MAGE-D4B is a novel marker of poor prognosis and potential therapeutic target involved in breast cancer tumorigenesis, Int J Cancer, May 1;130(9):1991-2002, doi: 10.1002/ijc.26200.
Gleeson M, O'Marcaigh A, Cotter M, Brosnahan D, Vulliamy T, Smith OP (2012) Retinal vasculopathy in autosomal dominant dyskeratosis congenita due to TINF2 mutation, British Journal of Haematology 2012
Hanrahan F, Campbell M, Nguyen A.T, Suzuki M, Kiang A.S, Tam L.C, Gobbo O.L,
Dhubhghaill S.N, Humphries M.M, Kenna P.F, Humphries P. (2012) On further development of barrier modulation as a technique for systemic ocular drug delivery. Adv Exp Med Biol. 2012;723:155-9. Review. PubMed PMID: 22183328.
Humphries MM, Kenna PF, Campbell M, Tam LC, Nguyen AT, Farrar GJ, Botto M,
Kiang AS, Humphries P (2012) C1q enhances cone photoreceptor survival in a mouse model of autosomal recessive retinitis pigmentosa. Eur J Hum Genet. Jan;20(1):64-8. doi: 10.1038/ejhg.2011.151. Epub 2011 Aug 24. PubMed PMID:21863053; PubMed Central PMCID: PMC3234518.
Kumar D, O'Hare B, Timon, C, Mukhtar M, Kelly D (2012) Bilateral pneumothoraces and pulmonary oedema following tracheonstomy induced by acute tracheal obstruction, BMJ Case Reports 2012; 10.1136/bcr-2012-006557,
Linge A, Kennedy S, O'Flynn D, Beatty S, Moriarty P, Henry M, Clynes M, Larkin A, Meleady P, (2012) Differential expression of fourteen proteins between uveal melanoma from patients who subsequently developed distant metastases versus those who did not, Invest Ophthalmol Vis Sci, 9;53(8):4634-43
McAnena L, Murphy C.C, O'Connor J (2012) Tarantula keratitis: a case report. Ir J Med Science Dec 5 2012.
Nguyen A.T, Campbell M, Kenna P.F, Kiang A.S, Tam L, Humphries M.M, Humphries P (2012) Calpain and photoreceptor apoptosis. Adv Exp Med Biol. 2012;723:547-52. Review.PubMed PMID: 22183376
Palfi A, Chadderton N, McKee A.G, Blanco Fernandez A, Humphries P, Kenna P.F, Farrar G.J. (2012) Efficacy of codelivery of dual AAV2/5 vectors in the murine retina and hippocampus. Hum Gene Ther. 2012 Aug ;23(8):847-58. doi: 10.1089/hum.2011.142. Epub 2012 Jul 20. PubMed PMID: 22545762.
Tam LC, Kiang AS, Campbell M, Keaney J, Farrar G.J, Humphries M.M, Kenna P.F,
Humphries P (2012) Protein misfolding and potential therapeutic treatments in inherited retinopathies. Adv Exp Med Biol. 2012;723:567-72. Review. PubMed PMID: 22183379.
Submitted for publication:
Power W, (2012) The role of cell culture set up in the growth of cultured limbal-cornea epithelial stem cells. Target journal – Experimental Eye Research
Power W, (2012) Gene expression profile of cultured limbal-cornea epithelial stem cells and cultured limbal fibroblast cells, Target journal – Molecular Vision
Chan T, De Chaumont C, Jefferies C.J, Ni Gabhann J, Murphy C.C (2012) Investigating the impact of HSK on TLR and IFN signaling in peripheral blood mononuclear cells, RAMI Winter Meeting 2012.
Chan T, De Chaumont C, Jefferies C.J, Ni Gabhann J, Murphy C.C (2012) Investigating the impact of HSK on TLR and IFN signaling in peripheral blood mononuclear cells, RCSI Annual Research Day 2012.
De Chaumont.C, Tyson C, Shahnazaryan D, Malone C, NiGabhann J, Jefferies C.J1, Murphy C.C (2012) Investigating the effect of corneal Herpes Simplex Virus-1 infection on Toll-Like Receptor expression in human peripheral blood mononuclear cells, RCSI Annual Research Day, 2012.
Haroon M, Ramasamy P, O'Rourke M, Murphy C.C, FitzGerald O (2012) Uveitis and Spondyloarthroptahy, SpondyloArthritis Knowledge and Learning (SpArKLe) meeting 18th October 2012. [Education in Spondyloarthritis designed for the Rheumatology community in Ireland].
Haroon M, Ramasamy P, O'Rourke M, Murphy C.C, FitzGerald O, (2012) Uveitis and SpA. SpondyloArthritis Knowledge and Learning (SpArKLe) meeting 28th September 2012 [Education in SpA designed for Allied health rheumatology professionals].
Kennedy, S (2012) Proteomics of Uveal Melanoma, International Association of Pathology Capetown, South Africa, September 2012
Kennedy, S (2012) Cilary body teratoid medulloepithelioma occurring in an adult, International Academy of Pathology, Capetown, South Africa, September 2012
Kennedy, S (2012) Keratoconus treated by microwave therapy, British Academy of Ophthalmic Pathology, 29-30th March 2012, Sheffield, UK
Malone C, Shahnazaryan D, Conlon R, Anyiam A, Smith S, Ní Gabhann J, Murphy C.C, Jefferies, C.J (2012) Targeting Toll-Like Receptor Pathways in Herpes Simplex Keratitis, Irish College of Ophthalmologists Annual Conference, 2012.
Molloy D, Connolly M, McCormick, Haroon M, Veale D.J, Murphy C.C, Molloy E.E, Fearon U (2012) Acute serum amyloid A and TLR2 acitvation induces pro-inflamatory mechanisms in a novel ex-vivo temporal artery explants culture model of giant cell arteritis. European League Against Rheumatism (EULAR) 2012.
Molloy D, Connolly M, McCormick J, Haroon M, Veale D, Murphy C.C, Fearon U, Molloy E (2012) Blood Vessel Instability and Oxidative Damage in Giant Cell Arteritis. American College of Rheumatology 2012.
O'Rourke M, Connolly M, Fearon U, Murphy C.C (2012) Molecular mechanisms in the pathogenesis of acute anterior uveitis, Rheumatology-Ophthalmology meeting, RVEEH, Oct 2012.
O'Rourke M, Haroon M, FitzGerald O, Murphy C.C (2012) Acute anterior uveitis: an opportunity for earlier diagnosis in spondyloarthropathy. M RAMI Winter meeting, Dublin. December 2012.
O'Rourke M, O'Connor J, Kennedy S, Murphy C.C (2012) A description of the pathological features of corneal specimens of patients requiring tectonic penetrating keratoplasty for rheumatoid melt, Irish College of Ophthalmologists Annual Conference 2012.
O'Rourke M, O'Connor J, Murphy C.C, Kennedy S (2012) Pathological findings in rheumatoid corneal melt. EU Cornea, Milan 2012.
O'Sullivan, F (2012) PDA/IMB ESOF 2012 Satellite Conference. Making Gene & Cell Therapy Medicines a Reality. Repairing the Window of The Eye. July 10-11, 2012 Dublin, Ireland.
O'Sullivan, F (2012) The 2012 Ireland-Taiwan Symposium on Cancer and Stem Cell Biology. Corneal stem cells for transplant therapy. September 20th, 2012 Dublin, Ireland.
Ramasamy P, HenrM, Linge A, Horgan N, Murphy C.C, Clynes M, Kennedy S, Meleady P, (2012) Proteomics of Uveal Melanoma, Biotechnology in Action, National Institute for Cellular Biotechnology, 2012.
Ramasamy P, HenrM, Linge A, Horgan N, Murphy C.C, Clynes M, Kennedy S, Meleady P, (2012) Proteomics of Uveal Melanoma, European Vision and Eye Research (EVER) Conference 2012.
Ramasamy P, Henr M, Linge A, Horgan N, Murphy C.C, Clynes M, Kennedy S, Meleady P, (2012) Proteomics of Uveal Melanoma, Irish College of Ophthalmologists Annual Conference 2012 (Winner best presentation award).
Shahnazaryan D, Jefferies CJ, Murphy CC (2012) The role of viral regulatory protein ICPO in herpes simplex virus type 1 (HSV-1) keratitis, Irish College of Ophthalmologists Annual Conference, Dublin, Ireland 2012.
Treacy M.P, Treacy M.G, Dimitrov B.D, Seager F.E, Stamp M.A, Murphy C.C (2012) A method for prescription of inexpensive spectacles by non-specialist healthcare workers: S-Glasses. Irish College of Ophthalmologists Annual Conference 2012.

redpajama_set_name: RedPajamaCommonCrawl


In this 4:40 video you're going to see English presentation expressions to help you start your presentation's Q&A and how to answer a question. This is also a sample presentation, so you can use this to help you with any type of presentation you have to give.
So, why do you need to know how to start a Q&A and answer questions?
Well, every presentation will have a Q&A session. There's no escaping from this and actually, it's a really important time during your presentation. Please watch the following video presentation to find out why and how to easily handle the Q&A.
Thank you very much for the post! It is very helpful to me!
Thank you for the comment. Hope your presentation goes well.


World renowned for its natural deepwater channels, the Opera House and Harbour Bridge, Sydney has one of the worlds most beautiful harbours. It is also a thriving port which caters for an unrivalled mix of commercial shipping and recreational boating activities. Sydney Harbour's commercial wharves are located less than 10km from bluewater shipping lanes. The port handles a wide range of vessels through its 11 berths, including dry bulk, bulk liquids, general cargo and cruise. Facilities covering a total of 41.7 hectares are located in Walsh Bay, Glebe Island, White Bay and Circular Quay. Private facilities are located at Gore Cove . Sydney Harbour is also a leading destination for cruise shipping, with passenger vessel facilities located at the Overseas Passenger Terminal at Circular Quay and the White Bay Cruise Terminal. Sydney is the only port in Australia with two dedicated cruise terminals.
The Port of Melbourne is Australia's leading maritime trade hub for containerised, automotive and general cargo.
With approximately 3400 commercial ship calls to the port each year, the Port of Melbourne handles over 2.5 million containers annually amounting to around 35% of Australia's total container trade. In addition to the 7000 containers handled on average each day, the Port of Melbourne is also the focal point for the automotive trade handling around 1000 motor vehicles daily on average.
With an extensive capital investment program, including the $1.6 billion Port Capacity Project to accommodate future trade growth, the Port of Melbourne has excellent rail and road transport access as part of a logistics network which stretches across the south-east of Australia.
The Port of Brisbane is one of Australia's fastest growing container ports, and Queensland's largest multi cargo port. Located at the mouth of the Brisbane River, the Port of Brisbane's strategic location is free from urban encroachment, offering an efficient entry to market through direct connectivity to Australia's major road and rail networks.
With 7200 metres of quay line accommodating 31 operating berths, as well as world class cargo facilities for containers, motor vehicles, and bulk and general cargo, the Port of Brisbane handles product worth over $50 billion each year. The Port of Brisbane is also among the most environmentally focused ports in the world, with approximately 35% of its area dedicated as green space.
The Port of Brisbane is managed and developed by the Port of Brisbane Pty Ltd (PBPL) under a 99 year lease from the Queensland Government. PBPL is responsible for developing the port and related facilities, and for the provision of key services including maintaining navigable access to the port for commercial shipping and the operation of the Brisbane Multi-model Terminal. PBPL is focused on driving trade and business growth by working with customers to deliver outstanding development outcomes, facilitating efficiencies and innovation and striving to accommodate new opportunities.
Fremantle Port is vitally important transport infrastructure, supporting investment and economic growth and contributing to the local and State economy. Each ship visit to the Port of Fremantle creates the equivalent of 3.3 full-time jobs for one year and last year there were 1952 visits. As well as the direct employment it generates, Fremantle Port is linked to thousands of jobs in the many enterprises that depend on trade and contribute to household income. In 2011-12, Fremantle Ports returned $22.2 million to the Government of Western Australia through income tax equivalents and dividends. The Port of Fremantle in 2011-12 accounted for 74 per cent by value of WA's seaborne imports and 10 per cent by value of WA's seaborne exports. Trade with East, South East and Southern Asia amounted to 58.9 per cent of total port trade and Australian coastal trade accounted for 13.4 per cent. Total port trade was 28.2 million mass tonnes, with a value of more than $30.1 billion.
Located just 14 kilometres northwest of the State's capital city of Adelaide, Port Adelaide is a sea port city and the historic maritime heart of South Australia. The Port was one of South Australia's earliest settlements and represents South Australia's first State Heritage area. Today, Port Adelaide continues to be the main service point for shipping in the State. Positioned at the centre of Australia's southern coast, the port provides South Australia with a gateway to the world as the State continues to enjoy a significant increase in export activity with booms in the shipment of grains, wine, motor vehicles and automotive components, ores and concentrates. The Port of Adelaide consists of an Inner and Outer Harbor, complete with over 20 wharves including the Flinders Adelaide Container Terminal.


text:
Bad books or Bad Books may refer to the following:

 Bad Books (band), an American indie rock band
 Bad Books (album), a 2010 album by Bad Books
 The Bad Book, a 2004 book of collected stories by Andy Griffiths
 The Very Bad Book, a 2010 book of short stories by Andy Griffiths

redpajama_set_name: RedPajamaWikipedia


I have lived in the Lafayette area for over 30 years and along with my wife and family, cannot imagine calling anywhere else home. Our community is such a wonderful area. With Purdue University located here and Indianapolis and Chicago in close proximity, it offers me the opportunity to cheer on my favorite sports teams as well as pursue my passions for fine dining and theater.
I know and love life here, and it's important to give back to the community that I care so much about, and I am thankful that Allstate supports and encourages my efforts. I believe strongly that children and teens need a supportive environment to learn and grow, and that's why I support local youth programs. In order to help them be in a better place, I am a sponsor of Riley Hospital, and my wife is nurse practitioner at IU Health in Lafayette. I also help out at the Crossing which helps struggling students prepare for the future through job training and faith-based character education.
I'm in the insurance industry because I love working with and helping people, and I believe treating people courteously and honestly is the only way to do business. Whether you need auto, home, or life insurance, I'm here to help. I look forward to working with you. Please call or stop by either of my office locations today!
Ball State University Alumni Assoc.
Sarah come back to Lafayette from Raleigh, NC to join her dad at his Frankfort office. After training under him for 3 years she is the Agency Manager of Scales Family Insurance Agency.
Mike works with people on their Insurance needs. Mike can work with you on Auto, Home, Life and Retirement.
Stephanie has experience on Customer Service as well as she can sell you any products you need.
Proud to serve the areas of Lafayette. Call or email me today for a personalized insurance review.
Our team believes that helping others makes the Lafayette area stronger and healthier. Through our volunteerism, we are proud to have earned Food Finders Food Bank a $6,000 Allstate Foundation Helping Hands grant. We support its efforts to provide food for needy families in the community.
Scott Scales is insurance licensed in the state(s) of Indiana. If you do not reside in the state(s) of Indiana, please go to the Find an Agent section on allstate.com to search for another Allstate Agent or Personal Financial Representative.


The Jackson jacket is ready for dominating all occasions. As a hoodless version of our Belmont, it features our advanced heated technology, delivering added warmth from everyday life to epic adventure. The Jackson helps maintain body temperature on the coldest days of winter, while not having to sacrifice style or comfort.
Can I wash my Kelvin heated product?
Definitely. All Kelvin products are washing machine safe, although delicate cycle and hang drying is recommended. Care Instructions: Remove Battery Before Washing. Machine wash warm on delicate cycle. For best results hand wash in warm water. Do not bleach. Do not use softeners. Hang to dry. Do not iron. Do not dry clean.


Benne Seeds – Is There a Conspiracy?
Published 6/23/2011 . Last updated 1/13/2019 .
Home » Recipes » Tips and Featured Ingredients » Benne Seeds – Is There a Conspiracy?
The benne seed wafer vendor at the tourist market informed me that benne seeds are seeds "very similar to sesame seeds." "Interesting," I thought. Not to say that I've heard of everything, but I was surprised that I'd never heard of benne seeds before.
Later that same day, Jonathan and I went to Husk for lunch. If you are ever in Charleston, I highly recommend both Husk and McCrady's (one of the best meals that I've ever eaten!). Lunch service was fairly slow at Husk so our server had time to chat. "Can you tell me anything about these benne seeds that I'm seeing everywhere?" I asked. He was happy to explain that benne seeds were popular in Africa and brought to the United States by slaves. "That's how they came to be so common in Charleston. It's also the reason that we use benne seeds on our lunch rolls." I had no idea that I had just eaten benne seed rolls! Neat! I thought that they were plain, old sesame seed rolls. I renewed my resolve to use benne seeds in my cupcakes!
I knew that I would be going to the Marion Square Farmers' Market in a couple of days and I was sure that someone there could tell me where to buy benne seeds – maybe there was a vendor there who sold them. I wondered if perhaps in Charleston, benne seeds could be found in your everyday grocery store. The guys at the Charleston Spice Company were friendly and full of information, so I decided to ask them.
"Where can I buy benne seeds?" "Benne seeds are just sesame seeds," they told me with confidence. It couldn't be!
Using the term benne seeds is a Charlestonian conspiracy to get tourists to buy sesame seed wafers that they otherwise wouldn't purchase – genius marketing at work.
The term "benne seed" is something that I should have known about. It's just a regional difference like saying "pop" vs. "soda" that everyone is aware of.
As you might guess, I prefer theory one. What's your take?
Did I Use Benne Seeds In My Charleston-Themed Cupcakes?
You bet I did! Look for the cupcake post soon!


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LifestylePRO
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Billy Joel Cleans Up Beaches, Protects Elephants
By Megan Savage
Courtesy of au.news.yahoo.com via AP
This weekend, Billy Joel assisted New York Governor Andrew Cuomo in cleaning up beaches on New York's Long Island. The singer's contributions were part of the 21st Annual Oyster Bay Beach and Harbor Cleanup. Around 10am on Saturday, Cuomo, who is currently seeking reelection, arrived with Joel at the Theodore Roosevelt Memorial Park by boat. They joined other elected officials in the project, walking along the shore with black plastic garbage bags and filling them with debris. They spent the remainder of the day picking up litter across the beach. Joel explained that he knows firsthand how much garbage gets thrown into the bay because it frequently washes up on his property.
The musician has backed various other eco-friendly efforts, making generous contributions to the Rainforest Foundation Fund and Farm Aid. In June, he showed strong support in the ban of ivory sales, writing on his website: "I wholeheartedly support the ivory sales ban bill pending in New York State. I am a piano player. And I realize that ivory piano keys are preferred by some pianists. But a preference for ivory keys does not justify the slaughter of 96 elephants every day. There are other materials which can be substituted for piano keys. But magnificent creatures like these can never be replaced. Music must never be used as an excuse to destroy an endangered species. Music should be a celebration of life – not an instrument of death."
Fans have also noted some environmental themes in Joel's music. His 1982 song, "Allentown" is written from the perspective of a man living in Allentown, Pennsylvania, where coal mining has peaked. The lyrics portray the declining quality of life with lines like "So the graduations hang on the wall / But they never really helped us at all / No they never taught us what was real / Iron and coke / And chromium steel / And were waiting here in Allentown / But they've taken all the coal from the ground / And the union people crawled away."
Additionally, his 1989 song, "The Downeaster 'Alexa,'" echoes similar themes, but addresses collapsing fish stocks from the perspective of a fisherman. "I've got bills to pay and children who need clothes / I know there's fish out there but where God only knows / They say these waters aren't what they used to be / But I've got people back on land who count on me."
21st Annual Oyster Bay Beach and Harbor Cleanup
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fdrmxnews
Rainforest Foundation Fund
The Downeaster 'Alexa
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text:
Trojan Family Magazine
Alumni Life
Trojan Tributes
The Trojan Who Became a Brigadier General
Viet Luong '87 makes history as the first Vietnamese-born U.S. military general.
by Susan Bell
Viet Luong '87 was only 9 years old when his family barely escaped war-torn Vietnam.
Along with hundreds of other Vietnamese fleeing Communist reprisal, Luong, his parents and seven sisters found refuge aboard an American aircraft carrier. "My sisters and I were scared to death," Luong recalls. "When we landed on the USS Hancock, it was so big… We asked our father, 'Dad, where are we?' He said, 'We're on a U.S. carrier.' We said, 'What does that mean?' And he replied, 'It means nothing in the world can harm you now.'"
The following day, Saigon fell.
Luong still gets choked up thinking about his family's harrowing experience, but he has come a long way from that fateful day: In 2014, Luong became the first Vietnamese-born officer in the U.S. military to achieve the rank of brigadier general.
Today, Luong is the 1st Cavalry Division's deputy commanding general for maneuver and most recently was in Afghanistan. The infantry officer commanded a battalion of 82nd Airborne Division paratroopers in Iraq in 2007–08, and led the 101st Airborne Division's 3rd Brigade Combat Team, the storied Rakkasans, into combat in Afghanistan in 2010–11. He has also served in Haiti, Bosnia and Kosovo.
I just try to do the best I can in every job given.
Viet Luong
He credits his fellow Army officers for helping him get his first brigadier general's star. "I just try to do the best I can in every job given," Luong says. "I would not be where I am today without all the help I have received from my subordinates and superiors."
College Dreams
His hardscrabble upbringing also played a role. After their escape, the Luongs relocated to Los Angeles and started from nothing to build a life. His father, who had majored in English literature and served as a senior officer in the South Vietnamese infantry, found work as an armed security guard, while Luong's mother worked in a fast food restaurant. Luong's older sisters worked too, but when one was robbed at gunpoint during a shift at a Hollywood gas station, Luong's father decided all his children were going to college.
Luong applied to USC thinking he'd never be able to attend, and set his hopes on state universities. A chance encounter with a Reserve Officers' Training Corps (ROTC) instructor at USC opened his eyes to new possibilities.
The instructor had served in Vietnam and was a paratrooper—exactly what Luong hoped to one day become. In 1983, Luong was accepted at USC with a full ROTC scholarship. "It was a bold move to go to USC," Luong says. "I chose USC not only for its legacy of academic excellence, but also because of how its alumni have fared in Southern California."
Luong majored in biological sciences at the USC Dornsife College of Letters, Arts and Sciences. "Being a science major taught me to think critically," he says. "I can cut through a lot of fluff and get to the root of the problem, and that has been one of my greatest strengths in my career."
He feels tremendous patriotism for the country that not only saved his life but also gave his family a chance to fulfill their aspirations through education.
His career is a thank-you from that 9-year-old boy on the USS Hancock. "At the end of the day," Luong says, "you have to ask yourself: What are you doing to contribute to our nation?"
Alumni LifeAlumniMilitary
August Wilson is known for his poignant explorations of Black culture and experience. (Photo/Netflix)	Call of Duty
Veteran and Firefighter Who Saved Countless Lives Struggled to Save His Own
Burdened by tragedy and pain, USC alumnus Michael Washington almost gave up on life. Now he helps other first responders find hope and healing.
6 min readAlumni Life, Social Impact, Alumni, Mental Health, Social Work	 October 19, 2021
August Wilson is known for his poignant explorations of Black culture and experience. (Photo/Netflix)	A Blueprint for Change
USC Alumna Prioritizes Sustainability and Access as California's State Architect
As California state architect, Ida Clair '87 helps set the standard for building sustainability, accessibility and safety.
3 min readAlumni Life, Architecture, Housing, Schools, Sustainability	 October 19, 2021
August Wilson is known for his poignant explorations of Black culture and experience. (Photo/Netflix)	Stage Crew
The 6 Degrees of August Wilson and USC
Check out these surprising links between the award-winning playwright and the Trojan Family.
2 min readAlumni Life, Arts, Student Life, Alumni, Dramatic Arts, Performing Arts, Students	 October 19, 2021
A magazine for alumni and friends of the University of Southern California
© 2022 USC Trojan Family Magazine
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find out about the next issue by email


things are getting very hairy!
It is freezing cold in Atlanta Georgia today.
The cold snap that dumped buckets of snow in the northern states has moved into the south with a vengeance, and all I can say is…thank goodness for the winter coat!
My girls and I were just discussing our winter coats the other day. I jokingly told them they didn't need new razor heads because the cold front was moving in, and they would need that extra layer of fur. Who knew I would be so right?
I'm pretty sure the human body was designed this way…to build a nice warm outer coat of hair to keep us warm in colder weather. But as American women, we work diligently to remove this fur coat before it has a chance to fill in.
Unless we run out of razors.
This is when a household of three women turns into a war zone. With only one unused razor head and three sets of hairy legs, the battle can get ugly! Of course, I had the razor head stashed in my bathroom, so the only way anyone could get it would be if I relinquished it. But I had no desire to give up my precious razor. If you hadn't noticed lately, razors are expensive these days, and I haven't been clipping coupons.
My husband believes that in tough times, people grow their hair longer and let beards come in to save on trips to the salon. I believe this financial conservation extends to women and their razors. We try to stretch it out longer and longer.
But at some point, it becomes ridiculous.
The girls and I were comparing our situations…in the most ridiculously exaggerated manner. We were trying to compete for the most desperate condition to win the remaining razor head. Despite the fact that I should have won, I did not, and I relinquished the last razor to one of the girls. Honestly, I didn't even realize under arm hair could get that long!
Later that night I went to the store for milk and grabbed another package of razors.
I have decided that, cold weather and fiscal responsibility aside, women were not meant to have hair on their legs or under their arms. There is something very unladylike about that. And as much as my husband likes to conserve energy and resources, it would seem that he is willing to splurge in the razor department.
Until the next time…I'll be shedding that winter coat just as the really cold weather hits!


I was in Madison on Saturday when Iraq Veterans Against the War group was invited to speak. The crowd went crazy when we filed into the rotunda of the Wisconsin State Capital that evening, all of them cheering our small group on.
As we each took a brief turn speaking, the entire crowd roared its approval and the sound was deafening; you could've heard the noise miles away from the rotunda. Except for the RNC protests, I've never witnessed this kind of approval of our message before.
Driving home that night, I felt that the crowd response was a validation of all that we had been trying to do since IVAW was formed too many years ago, a repudiation of the past where we had been accused of being unpatriotic, and that people finally got our message. And it felt good.


Easy-casting Berkley Vanish has become the top-selling mainline fluorocarbon in the U.S. and Canada. Berkley has been continuously improving the Vanish formula since it was introduced over 15 years ago, to ensure your satisfaction. One of the great values in 100% fluorocarbon line!
Remains clear underwater - 100% fluorocarbon refracts light similar to water.
Sinks underwater - more sensitive and a more direct profile from rod tip to lure.
Superior Wet Strength - Non-absorbing fluorocarbon maintains strength and abrasion resistance underwater.
Flexible - Most fluorocarbons are stiff, Vanish is more flexible.


So instead I'll share them here in hopes that they'll inspire you as well.
Coldplay's song "Up and Up" and its music video are masterpieces. The music video takes you through alternate realities that almost feel like puns on every day scenes.
Elizabeth Gilbert has been earning herself a household name on creative blogs and for good reason. Her podcast "Magic Lessons" is off the charts inspiring for anyone living a creative life.
I've recently connected with Kayla Hollatz who runs a powerful blog on finding your tribe, but more than that, Kayla is a ridiculous writer. Her poetry has me wanting to create personal photo projects based off of my own interpretations of her words.
Sam Larson is one of my all-time favorite illustrators right now. Even if you're not a huge fan of the outdoor life, there is still so much to be appreciated about his art. Jesse and I purchased this print and this print for our bedroom gallery wall. And secretly I want this one as a tattoo.


Our drinking water is still good!
Last year, readers of the Bulletin d'Aylmer may recall me commenting on how good the water tasted in Aylmer. I'm happy to report that this is still the case. I'm glad because I'm on a new medication that research has shown to slow the growth of polycystic kidney disease, which I inherited from my father. One side-effect is that I'm more thirsty, so I drink even more water.
I'm now a local volunteer for the Kidney Foundation of Canada. We are planning several events, leading up to the Outaouais Kidney Walk, June 2. This is the Foundation's major source of donations every year.
We need more volunteers: to help us with this major event, please call or text Nicole Jalbert at 819-290-1215, or via email at nicole.jalbert@rein.ca.
Between April 6 and 28, volunteers (including myself) will go door-to-door, seeking donations for our cause. When a Kidney Foundation representative knocks at your door, please be generous!
On Saturday, April 27, on the concourse beside Pharmaprix at Les Galeries de Hull between 10 am and 5 pm, you can find out if you are at risk of kidney disease. A registered nurse will check vital signs, with information, for anyone who stops by our kiosk.


The Fiftynine line offers a range of styles and variations that gives a warm and stylish vibe to your interior.
A match to the Fifytnine Sofa Bed, this armless chair features the same functionality as the sofa bed model – multi-coloured button tufted seat and backrest as well as the same 3-level recliner function. Enjoy the same comfort as its sofa bed counterpart, thanks to its system of pocket springs and high grade foam.
Designed to interact with other complementing sofas and chairs, expand your living space with the Fiftynine Chair. For instance, match this chair with the armless sofa bed model to create a longer sofa, a day bed or even a chaise lounge.
Create the perfect chill sport for you and your guest by pairing this chair with its sofa bed counterpart.


text:
Geoffrey Blancaneaux (born 8 August 1998) is a French tennis player.

Blancaneaux has a career-high ATP singles ranking of World No. 134 achieved on 14 November 2022 and a doubles ranking of World No. 164 achieved on 18 July 2022.

Junior Career
Blancaneaux won the 2016 French Open boys' singles title, defeating Félix Auger-Aliassime in the final.

Professional career

2017: Grand Slam debut
In September 2017, Blancaneaux made his Grand Slam debut, after receiving a wildcard to enter the main draw at the US Open.

2021: First Challenger win
In December 2021, Blancaneaux won his first Challenger Singles tournament at the Maia Challenger, defeating Tseng Chun-hsin in the finals.

2022: French Open, Masters and top 150 debuts
Seeded No. 190 at the 2022 French Open he qualified to make his Grand Slam debut at this Major in his sixth attempt.

He reached the top 150 on 8 August 2022.

In October, Blancaneaux made his Masters debut, after receiving a wildcard to enter the qualifications at the 2022 Rolex Paris Masters.

Junior Grand Slam finals

Singles: 1 (1 title)

Performance timeline

Singles

ATP Challenger and ITF Futures/World Tennis Tour finals

Singles: 17 (14–3)

Doubles: 13 (7–6)

References

External links

1998 births
Living people
French male tennis players
Tennis players from Paris
French Open junior champions
Grand Slam (tennis) champions in boys' singles


Rachel Reimer, 97, of Goessel, died Dec. 21, 2008, at Bethesda Home of Goessel.
Born in Canton, she was the daughter of Frank and Anna Banman.
On Sept. 8, 1934, she married Karl C. Reimer at Alexanderwohl Mennonite Church. He preceded her in death.
She was a homemaker and worked for 25 years at Salem Hospital and Home.
She also was preceded in death by a sister, Arpa Goertzen; a brother, Arthur Banman; and two grandchildren.
Survivors include three daughters, Darlene Schmidt of rural Newton, Ruth Warkentin of Santa Barbara, Calif., and Velma Schuessler of Sedgwick; seven grandchildren; and 10 great-grandchildren.
Services were Saturday at Alexanderwohl Mennonite Church.
Burial was in the Alexanderwohl Cemetery.
Memorial contributions have been established with Bethesda Home or Harry Hynes Memorial Hospice.


This tutorial has been updated to match the naming convention used in the IOR foot paper. The original tutorial can be found here.
In 2014, updates to the IOR foot model were published. The updated tutorial can be found here.
Sample data can be downloaded here.
Once the zip file has been downloaded, you can find a static C3D and three dynamic trials in the SampleFiles folder. These files will be used to complete the tutorial.
The model, planar angles and joint angles for the right side were defined and plotted in the Leardini_2007_Angles.cmo. Once the left side angles have been defined, the report template will graph both the left and right angles.
Visual3D is a general tool capable of implementing many different foot models.
TN (FNT)  : p.165 = Medial apex of the tuberosity navicular.
* Serge Van Sint Jan describes palpation for the mediolateral borders of this landmark (PM6/PL6), the target should be placed at the midpoint.
NOTE: This tutorial follows the naming convention presented in the IOR Foot paper.
In the Segments tab, select RMet in the Segment Name box.
Click on the Create Segment button.
Click on Close Tab before proceeding.
The image to the right (and all other images in this tutorial) show a mediolateral view of the segment coordinate system after it has been modified.
In the Segments tab, select RMid in the Segment Name box.
In the Segments tab, select RCal in the Segment Name box.
In the Segments tab, select Right Foot in the Segment Name box.
In the Segments tab, select Right Shank in the Segment Name box.
The F2Pt and F2Ps planar angles are calculated as the angle between the lines created by the targets FMB-FMH and FMH-PM. To calculate this angle using the Compute Planar Angle command, an offset along the line between FMB and FMH is created to define the 3 point angle.
The F2G, S2G and V2G angles are calculated in the plane orthogonal to the ground. These landmarks will need to be projected onto the ground. To project landmarks onto the ground, the Lab_O, Lab_X and Lab_Y landmarks will need to be created to identify the plane of the ground.
Note: The reference segment will need to be changed to RMet within the text option.
Note: The reference segment will need to be changed to LMet within the text option.
The FMH_proj and FMB_proj landmarks will be used to calculate the F2G planar angle which are described in the landmarks section.
The SMH_proj and SMB_proj landmarks will be used to calculate the S2G planar angle which are described in the landmarks section.
The VMH_proj and VMB_proj landmarks will be used to calculate the V2G planar angle which are described in the landmarks section.
This page was last edited on 7 August 2018, at 12:53.


Well, this is my first try to post a photo from my blog. If it works, I'll send a few more. If not, it's back to the drawing board!
Okay, back to the drawing board!
That was disappointing! I was so looking forward to seeing your bees. That said, no criticism aimed at you as I wouldn't have a clue how to post a photo and don't have the means to take and down load one anyway.... it makes a bit of a mockery of me being site admin doesn't it!!!
rather than the one you tried, which I think is your internal "bloggers" link.
Okay, Adam, next question: How do I make the photos a bit smaller, AND, how would I post more than one at a time??
I know Phil explained this, but I need to be told from six different people before it sinks in....!
Thanks Adam for facilitating that.
Sue, your blog is poetic and colourful and just paints such a wonderful picture and your comment abut the neighbours wondering what you are up to crawling about on the "magic carpet" did make me laugh. If only they knew!
Now I really want to come and visit!
Thanks so much for posting them.
Thanks! It is fun to share these with my friends across the big waters! I'm trying to make "gobsmacked" a slang word here. It is so great a term!


text:
Ross Harris may refer to:

 Ross Harris (actor) (born 1969), American actor, artist, and musician
 Ross Harris (composer) (born 1945), New Zealand composer and musician
 Ross Harris (footballer) (born 1985), Scottish footballer

See also
 Harris Ross, long distance runner
 Justin Ross Harris, American computer scientist convicted of his son's murder


Need hazza and gonzo back to balance it out a bit.
Before the election, it was VERY clear what kind of man Trump was, and what kind of President he would be.
The only thing we know about him now that we didn't know then, is the sheer scale of his decades-long tax fraud and the size of his handouts from his dad.
And just HOW blatantly he puts his personal advancement over the national interest.
But everything else was already there. We knew he was corrupt. We knew he was embarrassingly ignorant. We knew he was a pathological liar. We knew he had absolutely zero knowledge or interest in any policy except tax cuts for billionaires and his stupid wall.
We knew all of this - it was on full display before the election and he has been exactly the President that he looked like he was going to be.
If anyone voted for him thinking that he was going to be anything other than what he has been, then either they weren't paying any attention at all, or they are a moron.
It's going to get much worse though.
Trump was working harder for the American people this week than he was Dec/Jan. From Monday to Thursday last week, he only spent 50% of his time in "Executive Time". As opposed to 60% for the last leak.
I thought Joe was a guy?
I think you are forgetting how disastrous George Dubya really was. Two stupid wars that we are still dealing with, the patriot act, a horrible economy, etc.
Why haven't you changed your avatar yet?
if you want I will swap the avi.
I may look into it but I still doubt many vets like what the hell has happened to their country.
President Donald Trump's approval rating hit 52 percent for Feb. 11, according to a new survey.
Rasmussen Reports, which carried out the daily tracking poll, said it was Trump's "highest level of approval since shortly after his inauguration" in January 2017.
you want to post a meme?
and one thats maybe close to being true?
seems to have worked with the Ocasio-Cortez thread,yeah?
You should let real U.S. Marine veterans worry about our Country. Have you ever even been here?
It's funny though, Rasmussen is the only polling agency getting anywhere near those numbers right now.
Trump is LYING about walls and crime stats?
Im sure that discovering ones opinions are based on lies will change the opinion of our resident trump supporters,right?
trump supporters wouldn't be so stupid as to fall for such an obvious play,right?


Solar Water Heater information and a solar hot water system DIY project.
Solar hot water options for homeowners.
A solar water heater will save you big bucks on hot water. Look at solar water heating options if energy efficient hot water is on the list of green upgrades you're considering for your home.
Solar hot water means more green for the planet... and more green in your pocket, too!
Investing in a solar water heater is a win win situation. The planet breathes a little easier and you save money - as much as one third - on your power bill.
Solar water heating systems are simple designs that rely on the sun to heat the water and super insulated tanks to store it. You can even make your own solar water heater for next to nothing (video demonstration below).
More sophisticated designs are available online and we'll link you to some of our favourites. Inexpensive and environmentally benign, a solar water heater will pay for itself repeatedly in the coming years. Additionally, tax incentives, rebates and other money saving programs exist in most developed nations for establishing any energy efficient hot water heater.
Economical - some would say cheap.
Short Pay Back Time - Depending on the type of solar hot water system you choose it'll pay for itself in 3 to 7 years. After that you'll have free water heating for many more years.
No operating costs (unless you add a pump to the system).
Removes pressure on the existing power infrastructure in your community.
Heating water with solar takes a significant load off of existing infrastructure.
Over a 20 year span, using a solar hot water system can displace over 50 tons of carbon dioxide that would otherwise have been released into the atmosphere.
Approximately 30% of your household energy bill represents water heating costs. More if you have a heated swimming pool.
Taking your water heating needs off the grid removes pressure from your existing energy infrastructure.
As demand for energy increases in municipalities, existing infrastructure can become overburdened and unable to keep up with demand. Some municipalities have adopted a routine of rolling brownouts (times of the day where energy is rationed) to avoid having to go the the considerable expense of expanding their facilities and their output potential.
Building new power plants to address the demand is very expensive not to mention a move backward when, internationally, the mandate is to clean up our energy act. It's less expensive and more progressive to encourage residents (with incentives and rebates) to switch to clean, green, energy sources. Check for local and federal incentives in your area.
Pay back time is from 1 to 6 years depending on a number of variables.
Cost of the system is from $1,000 to $3,500, again, depending on some variables.
An active, glazed system will cost the most and produce between 80 and 100 gallons of heated water daily.
Passive solar hot water systems cost less but produce less hot water and pressure is reduced.
A solar power water heater is capable of reaching temperatures of 82 degrees celsius (180F) .
(pictured at right) look more like a solar panel - flat, rectangular and covered with glass - than unglazed.
Constructed of more expensive materials (copper), glazed panels are more durable and can be coaxed to function in below freezing temperatures. They're also the more expensive choice.
Sunlight passes through the non reflective glazing panels and collects on a dark absorber plate behind the glass. Tubing is looped back and forth under the glass next to the dark plate and through the tubing circulates air, water or an antifreeze solution. As the fluid or air in the tube warms, it moves off to a well insulated storage tank or is used immediately.
water heaters consist of lengths of black hose or pipe which is exposed directly to the sunlight (no glass cover).
The pipe is usually coiled or looped into a compact unit that is placed in a sunny area preferably on a black surface (the more heat, the better). Water fills the pipe and the heat that the black pipe collects is then transferred to the water.
The hot water can be used directly from the unit or directed to an insulated tank for storage.
If the collector is situated on a roof or other elevated structure the hot water can be accessed by gravity (another free source of green energy).
In climates where temperatures never dip below freezing an unglazed solar water heater will probably meet all of your requirements.
Here's a great video on assembling an unglazed passive water heater. Minimal materials are needed to assemble this easy DIY solar hot water system. Use it for your home water supply or to heat a swimming pool and start saving money right away.


text:
Q: PowerBI variable selection from union tables I have two tables, table1 & table2. I created 'Union' of these two tables in PowerBI.
table1
id   city   fruit         table
a1   NY     apple         table1
a2   NY     apple         table1
a3   NY     pear          table1
a4   MI     pear          table1
a5   MI     apple         table1
a6   MI     strawberry    table1
a7   TO     strawberry    table1
a8   TO     strawberry    table1
a9   TO     kiwi          table1

table2
id   city   fruit         table
a11  NY     rockmelon     table2
a12  NY     rockmelon     table2
a13  BJ     pear          table2
a14  BJ     pear          table2
a15  BJ     apple         table2
a16  LA     blueberry     table2
a17  LA     blueberry     table2
a18  PA     blueberry     table2
a19  PA     kiwi          table2

I would like to create a filter "filter1", which takes all rows if fulfilling these criteria:
"city" in table1 is "MI", or "fruit" in table2 is "blueberry".
If the criteria is met, call it "Awesome" in the dropdown of "filter1".
Can you please see if the following measure is in the right direction, and how to proceed? Thank you.
filter1 =
VAR
  table1 = FILTER('Union', 'Union'[table]="table1" && 'Union'[city]="MI")
VAR
  table2 = FILTER('Union', 'Union'[table]="table2" && 'Union'[fruit]="blueberry")

A: Awesome_test =
var filter1 =
FILTER(union, union[city]= "MI" && union[table]="table1")
var filter2 =
FILTER(union, union[fruit]= "blueberry" && union[table]="table2")
var filter3 = UNION(filter1, filter2)
RETURN
CALCULATE(MAX(union[id]), filter3)
// then pull the new measure into filter, select all that contains "a", then only those that fulfill the requirements are retained.

redpajama_set_name: RedPajamaStackExchange


text:
Warren Lindsey
Matthew Ferry
Lindsey & Ferry P.A. Central Florida Criminal Defense Lawyers
CALL OR EMAIL US TODAY - available 24/7
Charged with a sex crime in Florida? What you need to know
On behalf of Lindsey & Ferry, P.A. posted in Sex Offenses on Wednesday, June 4, 2014.
There is no doubt that facing criminal charges stemming from alleged sexual misconduct with a minor can be a traumatic and frightening experience. Many people who end up in this situation are first-time offenders who have no idea what to expect, what their rights are or how they might be able to defend themselves.
This lack of knowledge can work against a person who has been accused of serious sex crimes in Florida. There are state and federal agencies with extensive resources and information at their disposal, which can often give them a significant advantage when it comes to pursuing criminal charges. However, people who are targeted or arrested by law enforcement should remember that they have the right to speak with an attorney who can help them understand what has happened, what is at stake and how to proceed with a defense.
One of the most common or well-publicized tactics police use to arrest people for sex offenses is to conduct a sting operation. These can often consist of police officers acting or posing as a minor online and engaging in exchanges with men or women looking for companionship. In many cases, online conversations escalate to setting up an in-person meeting, which is when police often arrest the person who shows up. They can then pursue charges including online solicitation of a minor, traveling to meet a minor or other related offenses. If convicted, a person could be facing lengthy prison sentences, fines and the requirement to register as a sex offender.
But it is important to keep in mind that every situation can play out differently and every person who is arrested or under investigation is innocent until proven guilty. Having the support of a defense attorney can be very helpful in these situations, as an experienced attorney understands what to look for and how to craft a defense strategy.
It can be crucial to scrutinize every aspect of an arrest because it is possible that an officer has violated procedures designed to avoid entrapment. There have also been cases when charges were reduced or dismissed due to extenuating circumstances that played a role in a particular case. Identifying these factors can have a dramatic impact on what, if any, penalties a person may face.
Source: The Gainesville Sun, "Child-sex offenders: Who are they? How are they caught?" Chris Alcantara, May 24, 2014
Tags: Investigations, Sex Offenses
Related Posts: US DOJ: Sex offenders have low recidivism rates, Analyzing solicitation charges in a criminal context, A world without internet is impossible to imagine now, Dealing with the consequences of false rape allegations
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Drunk Driving Charges (62)
Sex Offenses (238)
What penalties might I face for violating the U.S. Copyright Act?
Driver's license suspensions can cause undue hardships
Restitution can come with white collar crime convictions
The 'Stand Your Ground' law applies to specific cases
Contact Our Attorneys Today
Attorney Warren Lindsey has been awarded the following credentials:
Our other attorneys and our firm have been awarded the following credentials:
& Ferry P.A.
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© 2020 by Lindsey & Ferry, P.A.. All rights reserved. Disclaimer


Recently, The Chinese Police force has been testing Sunglasses with facial Recognition list to take on suspects and those travelling using false identities.
Police are now beginning to use this Technology in the districts of Beijing with an expansion program for China, states Reuters.
The program was used as security when the Chinese parliament voted to increase President Xi's tenure to a lifetime which shows the increased surveillance and censorship in the People's Republic of China (which we really don't like), The Sunglasses where used to check travellers and match different car registration plates with the Chinese government's blacklist before the recently concluded annual meeting of the Chinese Government. The people on it's blacklist included journalists, political opposers, human rights activists and also criminals among many.
These sunglasses which are controlled by a mobile unit and cost $636 with some additional cash for its 'Facial Recognition Support', the device provides "instant and accurate feedback" for the police in contrast with the lag one gets when using CCTV according to Wu Fei, LLVision Technology's Chief Execeutive Officer in a statement to the Wall Street Journal last month.


Bruker's X-ray diffraction portfolio covers a wide range of X-ray scattering techniques for materials characterization and quality control of crystalline or non-crystalline materials such as powders, solid blocks, thin films or liquids.
Techniques include X-ray powder diffraction (XRPD), diffuse or "total" scattering (PDF analysis), small angle X-ray scattering (SAXS), thin-film analysis, and X-ray imaging. A unique platform design allows to configure each instrument for a wide range of applications.
The functional units of semiconductor and compound-semiconductor devices continuously shrink in size and thickness. Additionally, the structure of the devices becomes more and more complex, the process more and more expensive. Thus, the demand for reliable analytics, such as X-ray diffraction, for process development and at-line or in-line quality control increases permanently.
By introducing the D8 FABLINE, the analytical flexibility and reliability – known for the D8 DISCOVER family used in research and development – is now transferred to demanding clean room environments. The D8 FABLINE features a robot handling wafers up to 300 mm diameter as well as it can be equipped with two FOUP ports for routine analytics in quality control. Measurements and data analysis can be fully automated and, if required, Bruker AXS supplies the full service to adjust the analytics to the process requirements. Furthermore, SEC/GEM interface can be suited to user requirements, pattern recognition or bar code reading capabilities can be integrated.
The D8 DISCOVER with DAVINCI design increases ease-of-use with real-time component detection, plug-and-play functionality and fully integrated 2-dimensional XRD2 capabilities. These unique features allow the user to easily switch between all materials research X-ray diffraction applications, including reflectometry, high-resolution diffraction, in-plane grazing incidence diffraction (IP-GID), small angle X-ray scattering (SAXS), as well as residual stress and texture investigations.
The intelligent beam path components of the D8 ADVANCE with DAVINCI design provide true plug'n play functionality requiring minimum or even no user intervention. Featuring automatic and tool-free switching of the diffraction geometry without the need for complex adjustments the D8 ADVANCE with DAVINCI design broadens the analytical capabilities for a wide community of X-ray diffraction users.
Together with the 'Best-Data-Guarantee' which refers to the 'Alignment Guarantee' and 'Detector Guarantee' it just means: operating safety assured.
The D8 ADVANCE with DAVINCI design comes with the new software DIFFRAC.SUITE. The plug'n play functionality is consistently implemented: any component mounted to the instrument registers itself with its relevant parameters. The DIFFRAC.SUITE offers intuitive operation and the graphical user interface can be customized to match the operator's requirements, and last but not least features the leading algorithms of its predecessor DIFFRACplus – ease of use assured.


text:
North Center hit-and-run kills woman after nearby shooting reported, Chicago police say
Chicago shooting: North Center crash took place after shots fired near Damen, Irving Park Road, CPD says
ByMichelle Gallardo and Alexis McAdams, ABC 7 Chicago Digital Team
A Chicago hit-and-run killed a woman on Irving Park Road after a North Center shooting, CPD says.
CHICAGO (WLS) -- A woman was killed in a hit-and-run after a nearby shooting was reported Sunday morning in North Center on the North Side.
Surveillance video shows the moment a Nissan Rogue carrying two people slams into this North Center gas station just after 3 a.m. A 37-year-old female passenger was thrown from the car and killed, despite first responders best attempts to revive her.
The SUV she was in was struck by a grey Toyota Camry, which moments earlier had been speeding westbound on Irving Park Road from Damen Avenue as shots were fired, according to police.
A K9 Unit that spotted the scene unfold as it was happening gave chase, witnessing the deadly collision.
"He heard shots being fired. He sees muzzle flash coming from a Toyota sedan vehicle. The officer activates his lights. Calls it into the zone," said Migdalia Bulnes, deputy chief of the Bureau of Detectives, during a press conference later Sunday morning. "After striking the Nissan vehicle proceeded to spin around and landed by the gas station by the alley."
However, Bulnes said it was not immediately clear how the shooting originated.
The woman was taken to Illinois Masonic Medical Center, where she died, police said. She hasn't been identified yet.
RELATED: Kane County hit-and-run that injured man, 72, caught on security video
The driver of the Rogue, a 27-year-old man, was also taken to Illinois Masonic for observation, but didn't suffer any serious injuries, police said.
An unknown number of occupants fled from the Toyota on foot, police said.
WATCH: CPD gives update after deadly North Center hit-and-run
Investigators said those inside the Camry ran away and a weapon recovered from inside the vehicle. While initial reports claimed that the offenders inside the Camry were engaged in a gunfight with a second vehicle, police now say they're not sure exactly who or what they were shooting at.
"We're still looking at video and trying to piece it all together, whether there was another car indeed, or an individual that was also there and it was going back and forth," Bulnes said.
No one was in custody, according to police.
CHICAGO NORTH CENTER HORNER PARK HIT AND RUN CHICAGO SHOOTING CHICAGO CRIME FATAL CRASH SHOOTING CHICAGO VIOLENCE HIT AND RUN ACCIDENT
3 injured, 1 critically in hit-and-run crash on South Side: police
Woman struck by 2 vehicles in fatal West Side hit-and-run: CPD
Reward offered after woman, 93, killed in West Side hit-and-run
CPD release picture of car wanted in hit-and-run that killed woman, 93


CMS is the proud recipient of a $10,000 LSTA, Library Services and Technology Act, Grant for 2011. This project is made possible by a grant from the U.S. Institute of Museum and Library Services, administered by the Indiana State Library.
To provide a "Multimedia Center" where students and staff may work with innovative equipment that motivates the exploration and production of products that reflect 21st Century skills and learning. The end product being increased student achievement through the use of technology tools.
Animoto -Turn your photos and video clips into professional video slideshows in minutes.
Cacoo - Create diagrams online and with real time collaboration.
Glogster - Make your interactive poster easily and share it with friends. Mix Images, Text, Music and Video.
Learn about the purpose of the Multimedia Center and the technology supplied by the LSTA grant.


text:
Ryan Reynolds Spoofs In-Flight Safety Video as British Airways Begins Carrying Aviation Gin
Nicolas Cage Wants to Play Batman Villain Egghead: 'I Can Make Him Absolutely Terrifying'
Joseph Baena Honors 'Beautiful' Mom for Birthday: 'You Inspire, Motivate and Push Me'
Netflix Will Test Charging Users for Sharing Subscriptions Outside of Their Households
Of Course Jennifer Aniston Is Wearing Uggs on the Set of Murder Mystery 2
HomeUncategorizedCruise ship rescues 17 migrants from vessel near the Bahamas
Cruise ship rescues 17 migrants from vessel near the Bahamas
Seventeen migrants were taken onboard a Royal Caribbean cruise ship Saturday after it encountered a small vessel adrift on its way to the Bahamas, according to a statement from the cruise line.
The Liberty of the Seas was sailing to the Bahamas when it encountered a small vessel adrift and in need of assistance, according to Royal Caribbean officials.
"The ship's crew immediately launched a rescue operation, safely bringing 17 people onboard. The crew provided them with medical attention and is working closely with the United States Coast Guard," the statement said.
RacQuelle Major-Holland, a passenger on the cruise liner, told CNN the captain made an announcement their ship was diverting from its path to Nassau to see whether the small boat needed help.
"He shared there appeared to be people onboard and he mentioned the maritime law that ships have to check in and rescue if needed," Major-Holland said Monday.
She said the small boat was hard to see at first but within about 45 minutes of the announcement, the people were onboard the Liberty of the Seas.
"The individuals on the boat were waving and … they were smiling and happy to be rescued," said Major-Holland, a travel blogger from Pickerington, Ohio.
Video that Major-Holland recorded shows the boat getting closer to the ship. The tiny craft has just a few oars and a piece of tattered green fabric from what appears to be a makeshift flagpole.
Officials didn't identify what country the people in the boat were from, but the rescue comes during a surge of Cubans and Haitians attempting to make it to the United States.
It isn't new for cruise ships traveling near Florida to come upon boats of migrants. But a series of recent rescues and social media posts about them have brought a fresh wave of attention to these dramatic moments at sea and the migration crisis behind them.
The small boat in this case was in Bahamian waters and the people onboard reported there was another vessel out as well, a spokesperson from the US Coast Guard District Seven told CNN.
Because of the location of the vessels, the Bahamian authorities are leading the investigation with assistance from the Coast Guard.
CNN has reached out to the Bahamian Defense Force for additional information.


In the words of Craig David! "what's your flava" Bank accounts are going to cry but our shelves are going to have joy, well that's only if we get lucky to pick up more Ice-cream Dino's! "Not one, not two but three Ziqi wu's Ice Cream Dinos will be up for grabs this weekend. "Why so many? Unbox are hoping that multiple choices mean multiple opportunities for collectors to obtain one!" CHOCOLATE MINT ICE CREAM' & COOKIES & CREAM' EDITION Little Ice cream Dino will join the Toy Station 88 anniversary edition for TODAYS release.
LIMIT ONE PER CUSTOMER Per version.


Hi, I went into Sainsbury's to get some cartons of their unsweetened soya drink and could not find any. I asked the staff and I was told it has now been discontinued.
Was this the really cheap 'n' nasty budget one? I reckon you're better off without it! Pay the extra 40p or whatever, and get some Alpro.
Tesco's own brand (blue carton) for 63p is good too.
ETA: that's the sweetened one - the unsweetened one is 60p and organic.
Sainsbury's here have also stopped doing the Realeat VegeMince, does anyone know of any bread that is vegan other than Sainsbury's? It will save me a taxi fare to the other side of town if I can go to another store.
my local Sainsburys do Linda McCartney mince which is vegan.
Yes but I was told by this has now been discontinued.
What colour carton was the one that you used to buy, that they say has been discontinued? We buy the one in the red carton, but when we were in there the other week they were selling off the soya drink in the free from range (yellow carton) for 15p which could have meant that they were discontinuing it? I bought the red one today.
Yes it was the yellow carton in the freefrom range.
I thought it was, in which case I recommend the red one, have not tried the sweetened one though.
For bread, Hovis bread is often labelled vegan on the back. Depending on where you are, the co-op bread is labelled, including some of the bakery speciality bread.
I've noted that Linda McCartney veggie mince is now labelled vegan. But it's more expensive than Realeat. From a long time ago, Realeat veggie mince was nicer than Linda Mc, and the Realeat is now cheaper. So I haven't bought any of the Linda Mc.


Memoryallocation is required in all phases of design. It typically consists of onlytwo operations: the allocation of a specified amount of unused memory and thefreeing of an allocated block. Some systems reduce this to a single operationthat allocates on demand and frees automatically when the object is no longerused. Special garbage-collection operationsfind the unused memory by counting the number of references to each block[Deutsch and Bobrow].


Located in the Tsentralny neighborhood in Saint Petersburg, 2.3 km from State Russian Museum, Azart features free WiFi access and free private parking.All rooms are equipped with a flat-screen TV. All rooms include a private bathroom fitted with a shower. Extras include free toiletries and a hairdryer.There is a 24-hour front desk, a shared kitchen, concierge services and a shops at the property.Church of the Savior on Spilled Blood is 2.6 km from Azart, and Palace Square is 3.1 km from the property. Pulkovo Airport is 16.1 km away.


text:
Q: Bootstrap WordPress Menu: Add Custom CSS Class Good evening, I need to convert the following static menu into a menu for WordPress. Below is the HTML code:

                    Start Bootstrap
                    <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbarSupportedContent" aria-controls="navbarSupportedContent" aria-expanded="false" aria-label="Toggle navigation"></button>

Home

About

Contact

Pricing

FAQ

                                Blog

Blog Home

Blog Post

                                Portfolio

Portfolio Overview

Portfolio Item

While below the PHP code I have in the theme header.php file:
    <?php
                            wp_nav_menu(array(
                                    'theme_location' => 'menu-1',
                                    'container_id'    => 'site-navigation',
                                    'menu_class'      => 'navbar-nav ms-auto mb-2 mb-lg-0',
                                    'menu_id'         => 'primary-menu',
                                    'add_a_class'     => 'nav-link',
                                    'add_li_class'     => 'nav-item',
                            ));

                            ?>

Everything works fine but the "nav-link" and "nav-item" classes are not added. How can I solve?
Thanks

A: You can't normally add extra li classes without tweaking your theme.
Try adding this snippet in your functions.php file to allow you to add extra classes to your li tags:
// =======================================
// Customize Menus
// =======================================

        // Ability to add classes to wp_nav_menu LI tags

        add_filter('nav_menu_css_class', 'add_additional_class_on_li', 1, 3);

        function add_additional_class_on_li($classes, $item, $args)
        {
            if (isset($args->add_li_class))
            {
                $classes[] = $args->add_li_class;
            }
            return $classes;
        }

        // A tags

        add_filter( 'nav_menu_link_attributes', 'add_link_atts');

        function add_link_atts($atts)
        {
             $atts['class'] = "nav-link";
             return $atts;
        }

Now you can add this extra li class property like so:
       wp_nav_menu( array(
            'theme_location'    => 'full-width-menu',
            'depth'             => 1,
            'container'         => 'nav',
            'container_class'   => '',
            'container_id'      => 'mob-nav',
            'menu_class'        => '',
            'add_li_class'      => 'nav-item'
        ) );

Also you should look into using a bootstrap nav walker for wordpress.
https://dhali.com/wordpress/add-wp-bootstrap-navwalker-to-you-wordpress-theme/


text:
<?php

namespace App\Validation\Exceptions;

class XdigitException extends AlphaException
{
    public static $defaultTemplates = [
        self::MODE_DEFAULT => [
            self::STANDARD => '{{name}} contain only hexadecimal digits',
            self::EXTRA => '{{name}} contain only hexadecimal digits and "{{additionalChars}}"',
        ],
        self::MODE_NEGATIVE => [
            self::STANDARD => '{{name}} must not contain hexadecimal digits',
            self::EXTRA => '{{name}} must not contain hexadecimal digits or "{{additionalChars}}"',
        ],
    ];
}

redpajama_set_name: RedPajamaGithub


Congratulations to the pupils and teachers of St. Aiden's who received the award 'Outstanding Achievement in Film Making for Music'. Well done to all involved. A special word of thanks also for The Mayo Youth Orchestra and their conductor Ms Anne Moriarty ( Principal St. Aiden's).