When I was very ill with a debilitating disease, it was hard to imagine being healthy. In and out of ICU a few times over the years, and once in a hospital bed for six weeks, the doctors had no faith in my recovery. They told me I couldn't heal unless I left some pretty important body parts behind; parts that people can't really do without. Clearly it was not within my capacity to focus on anything but pain, weakness, and fear. But I knew that's exactly what I had to do. Against medical warning (and some family member's wishes) I left the hospital to heal at home. Now I'm not going to lie. It was very tough to fully embrace my imagination when my emaciated body was practically down to skin and bones and I could barely get out of bed without help. Yet every day I would lay there and see myself being healthy and happy…running around with the kids, laughing, and having fun. When you are that sick, even something as simple as driving a car seems impossible, but I would see myself driving the kids through Taco Bell (I know, but I was literally starving so work with me here).
The issue for many of us is that we often feel like we're at the mercy of the medical industry and we've long but given up self-healing efforts. Plus, people get scared when they are very ill, not to mention how hard it is to imagine yourself happy and healthy with tubes sticking out of your arms and pain wracking your body. And while the premise of this book is not focused on healing anything beyond hangovers(drink water), I will enthusiastically point you to the book by Dr. Joe Dispenza called, You Are the Placebo. This will help your skeptical brain understand way more of the science behind all this so you can start to heal yourself…and then apply all of the information in this book to get busy getting better too. But let's get back to the positive aspects of your brain and how you can use it to imagine whatever your heart desires.
What's ironically sad is that we all spend so much time and sweat equity trying to change things in our external world, feeling like we're banging our head against a brick wall…and guess what? We are! Now I'm certainly not saying you don't have to take actions and precautions in life, so don't go down that rabbit hole. What I am saying though, is that it's like looking at your reflection in the mirror, not liking how long your bangs are and trying to trim the mirror (careful, you'll cut yourself!).
Austiage is a former national-level champion fencer who was born in Washington, DC. She speaks seven languages, attended American University, and is the founder of the Star Individuality Foundation, a nonprofit organization that supports youths in developing their unique individuality. Her book The Mirror Said, "You're Be-You-Tiful" explores the societal pressures that many people are faced with today and offers a game plan for nurturing individuality and owning one's beauty.
You can visit Austiage's website at https://www.austiage.com/.
In her motivational self-help book, THE MIRROR SAID, "YOU'RE BE-YOU-TIFUL," former elite athlete Austiage offers readers a foundation for embracing their unique beauty in a world that doesn't always value diversity and individuality. Writing in a welcoming, conversational style, Austiage outlines a plan for embracing a positive self-image that develops from the inside out.
An unexpected question ("Does the mirror make you feel ugly?") was the spark that led Austiage to pen THE MIRROR SAID, "YOU'RE BE-YOU-TIFUL." She met the young girl, Julianne, who posed the question while donating supplies to a children's hospital. After talking with the girl about beauty and what it means, the author felt moved to share her thoughts with others on this delicate subject, which many people—young and old, male and female—frequently struggle with. The book has a powerful message that begins by focusing on the individual.
Austiage asserts that beauty is much more than aesthetic. She emphasizes that character is an essential component of beauty and encourages readers to bolster their character by being positive and kind to themselves and others. The author repeatedly stresses the importance of having a strong belief in one's self and explains how this belief affects how people see themselves, the type of people they invite into their lives, and the manner in which they take care of themselves and pursue their goals.
THE MIRROR SAID, "YOU'RE BE-YOU-TIFUL" takes an in-depth look at the necessity of self-care including eating well without foregoing pleasure, incorporating fitness and relaxation in one's daily life, using makeup to highlight and enhance one's beauty, discarding fear and doubt to follow opportunities to find one's passion, and reevaluating relationships to make conscious decisions about the people in one's life.
Finding your skills and talents—and using them—helps you become your best, beautiful self. Maybe you know exactly what your talents are, or maybe you need to find them. But everyone has a purpose on earth, and it is found through our talents and passions. If you don't know what your purpose is, you can find it. In reality, you actually do know what your purpose is—you are the sole authority on who you are. Maybe your talent is hidden and you have to find it. Or maybe you have taken your talent for granted and no longer look upon it as a talent. Either way it is there and it has always been there and all you have to do is notice it and embrace it.
To identify your purpose, ask yourself, "What makes me smile? What makes me happy?" Then analyze your answers. It may not always seem clear at first, so keep thinking. For example going out to restaurants with your friends and trying new foods makes you the happiest. Most likely your purpose is not eating, but it may be becoming a chef who creates new foods. Pay particular attention to environments you are attracted to. What you enjoy doing, where you enjoy being, who you enjoy spending time with—these are all part of your purpose in life.
When you feel lost in your life, remember that no one is born found; at some point we need to be lost in order to be found. When I'm feeling lost, I've learned not to say that I am lost (that has a negative connotation); instead I say I am currently on the path to becoming found.
Your purpose cannot come by force, finding passions and your purpose in life will come when it is time. You will find it even if you are feeling lost and destroyed. Many times we need to break in order to be rebuilt into who we are supposed to become.
Once you're purpose is clear, you become motivated. Self-motivation is so beautiful and attractive, although it is not something aesthetic. Be the person who wakes up with a purpose in life. Be the person who will chase their own dreams. People will only start to motivate you when they realize that you already are motivated.
Being self-motivated is not only something that others are attracted to, but being a self-motivated individual gives you a purpose in life which is then going to create confidence within oneself. Feeling beautiful always comes down to feeling confident and pride in ones self.
So many times when we think of being self-motivated as something that is difficult or we wonder if we have it in us to motivate ourselves. In reality becoming self-motivated is 4 simple P's: Passion, Purpose, Position and Positivity.
Passion: Ask yourself the questions: What am I passionate about? What do I love? What do I never get tired of doing? If you can find something you are genuinely passionate about you will always have a feeling of motivation regardless of how hard you need to work to accomplish the goals you have set. When you are also focused on doing something that you have a passion about you will also be a happier person overall. Purpose: you now have a passion you want to be involved in, now comes the tricky part is to determine what your mission is. You can find your purpose my asking yourself these questions: What about my passion inspires me? When determine what inspires within in a certain topic you have purpose because you know understand how you want to be involved within your passion.
Position: Being able to figure out what it is that you want to do within this topic is crucial. The best way to do this is to just get our a piece of paper and pen and just start to brainstorm all the different positions you could to take on with that passion, and once you have a list then just starting to number then in order of priority—based on your skills and goals. From there you'll be able to determine what position you want to take on.
Positive: Finally the last key on being able to being a self-motivated individual is to always have a positive outlook on the situation. Obviously there are highs and lows in life, so even if you are involved with some- thing that you are passionate about there are going to be times where not everything will go as you had planned. But understanding these situations and anticipating them will allow you to keep a positive outlook and will allow you to stay self-driven.


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Home About SEAS News & Events Hall of Fame Hall of Fame Members GW Engineering Hall of Fame Members (listing by year) 2015 Inductees
Donald L. Blount
Mr. Donald L. Blount founded Donald L. Blount & Associates, a naval architecture and marine engineering design firm in 1988. The company is noted internationally for design and engineering of high-performance, military, commercial, and recreational vessels. Noteworthy vessels exceeding speeds of 60 knots include gasturbine- powered vessels M/Y Destriero (222 ft, 1,000 mt), which established in 1992 the current Atlantic Ocean crossing record (58 hr 34 min) averaging 53.1 knots, and M/Y Fortuna (135 ft), the Royal Yacht of Spain. Previously Mr. Blount was a civilian employee of the Department of Navy for 35 years. In his early years with the Navy, he conducted research and engineering programs relating to technology in the field of hydrodynamics. The latter years were spent with the Navy's Combatant Craft Department conducting research, designing, and testing military craft with the last nine years as Department Head. In 2014 Mr. Blount published a book, Performance by Design: Hydrodynamics for High-Speed Vessels and has co-authored more than 50 papers and articles for international technical societies. Mr. Blount is a professional engineer and a Fellow of both The Society of Naval Architects and Marine Engineers and The Royal Institution of Naval Architects. He earned a Bachelor of Science in mechanical engineering from GW in 1963.
Gene Colabatistto
Mr. Gene Colabatistto has more than 25 years of experience in the global defense industry, and has held leadership positions in both the military and private sector. As president of defense and security at CAE, a global leader in immersive, integrated training systems, Mr. Colabatistto manages over 2,500 employees in 30 countries. In 2014, CAE was recognized by Canadian Defence Review as Canada's number one defense company. Previously, he held senior management positions at SAIC, Space Imaging, SPOT Image, and Veridian. Mr. Colabatistto also served in the United States Marine Corps as representative for intelligence systems and satellite and airborne reconnaissance during Desert Storm. His career has been dedicated to the innovative application of space, airborne, and intelligence technologies to issues related to national security. He has been recognized by the Director of Central Intelligence, Director of the National Reconnaissance Office, Secretary of the Navy, and the Commandant of the Marine Corps for "Significant Intelligence Successes" and Meritorious Service. Mr. Colabatistto was recently recognized in January 2015 by GovCon Exec as one the Top 100 most influential executives in Washington. Mr. Colabatistto is a commercial pilot and has served as an Angel Flight and Homeland Security/First Responder pilot. He is a 1996 alumnus of GW with a Master of Science in electrical engineering. Prior to that, he received a Bachelor of Science in aerospace engineering and a Master of Science in systems management from University of Southern California.
Elizabeth D'Andrea
Dr. Elizabeth D'Andrea is a senior scientist with more than 38 years in government service focused on weapons development and science and technology. In her years of service, Dr. D'Andrea was responsible for the development of the Navy's Railgun as well as numerous technologies focused on terrorism and drug interdiction. She has worked for NASA, the departments of the Army, Air Force, and Navy, and has directly supported the Office of the Secretary of Defense and the White House. Her recent accomplishments include critical technologies that have been applied to advanced engineering, science, physics, and materials for Department of Defense capabilities. Dr. D'Andrea has successfully transitioned multiple technologies into programs of record and has established technical consortiums to create innovative solutions. Her numerous recognitions include three Navy Superior Civilian Awards, the Navy Meritorious Civilian Award, the Langley Air Force Base Woman of the Year Award, and two Army Special Service Awards. Additionally, the Republic of Colombia, South America, recognized her with the Colombian Air Force Meritorious Service Cross. Dr. D'Andrea received a Bachelor of Science in quantitative methods in 1976 from Old Dominion University, a Master of Science in systems engineering in 1984 from Florida Institute of Technology, and a Doctorate of Science in engineering management in 2006 from GW
Kevin Kelly
Mr. Kevin Kelly is chief executive officer of LGS Innovations, a privately held independent technology company with strong ties to the defense and intelligence markets in the United States. Mr. Kelly oversees the development and implementation of the company's strategy and the overall performance of the entire company. Mr. Kelly brings more than 20 years of experience to LGS in the areas of research, engineering, strategic planning, and organization leadership. Previous positions in LGS were as the company's chief operating officer and senior vice president of strategy. In these roles, he oversaw the company's foundation as a wholly owned subsidiary of Alcatel-Lucent in 2007, and eventually led the efforts to partner with Madison-Dearborn and CoVant to purchase the company and migrate it to become an independent portion of Madison-Dearborn's portfolio. Prior to Mr. Kelly's 15-year history with LGS Innovations, he held senior positions within General Dynamics' Advanced Information Systems (GD-AIS) and Lockheed Martin. Mr. Kelly received a Bachelor of Science in electrical engineering from Penn State in 1993 and a Master of Science in engineering management from GW in 1997.
Ronald R. Luman
Dr. Ronald R. Luman is chief of staff of the Johns Hopkins University (JHU) Applied Physics Laboratory. He manages the laboratory's strategic decision agenda, guides laboratory policies and operations, and aligns annual investment resources to strategic objectives through a collaborative executive management process. Dr. Luman's technical leadership roles have spanned undersea and missile guidance systems, ballistic missile defense, and intelligence systems architectures, with special assignments at the U.S. submarine force headquarters in Pearl Harbor, the Office of Naval Research, the Missile Defense Agency, and the National Security Agency. As the Systems Engineering Program Chair in the JHU Whiting School of Engineering, Dr. Luman oversees the largest systems engineering master's program in the nation with more than 1,000 students and 125 adjunct faculty members, featuring industry cohort partnerships and worldwide online course delivery. Dr. Luman is a member of the National Research Council's Naval Studies Board, where he has addressed strategies for mainstreaming unmanned undersea vehicles into global naval operations, the role of naval forces in the war on terror, and the effects of climate change on national security. He received his Bachelor of Arts in mathematics from Middlebury College in 1976, a Master of Science in applied mathematics from Michigan State University in 1978, a Master of Science in technical management from Johns Hopkins University in 1986, and a Doctorate of Science in systems engineering from GW in 1998.
Patrick Marolda
Mr. Patrick Marolda is currently the chief operating officer for Rolls-Royce's Defence Division. There he has oversight and execution over all operational budgets and team performance metrics. He is responsible for developing and executing integrated departmental plans, policies, and procedures and driving improved quality, delivery, cost, and operating efficiency in all defence global operations. Mr. Marolda joined Rolls-Royce as president of Rolls-Royce Naval Marine Inc. in 2002 and has since held increasingly senior roles in the marine and aerospace businesses. His prior position was chief operating officer for Rolls-Royce Marine where he was responsible for all global marine operations and was headquartered in Oslo, Norway. Prior to joining Rolls-Royce, Mr. Marolda was president of Kidde Fenwal Safety Systems, the world's leader in providing eutectic overheat sensors to the aerospace market. Before that, he spent 20 years with General Electric (GE) in its Power Systems and Energy Divisions. Mr. Marolda received a Master of Science in engineering administration from GW in 1986. Upon graduation in 1980 from the New York Maritime College with a Marine Engineering degree, he joined the Military Sealift Command as a Third Assistant Engineer aboard the USNS Marias (TAO-57).
Christopher J. Scolese
Mr. Christopher J. Scolese is the director of NASA's Goddard Space Flight Center, a role he assumed in March 2012. He previously served at NASA as associate administrator, one of the agency's highestranking civil servant positions, at its headquarters in Washington, D.C. There Mr. Scolese was responsible for the oversight and integration of NASA's programmatic and technical efforts to ensure the successful accomplishment of the agency's overall mission. From January 2009 until July 2009, Mr. Scolese served as NASA's acting administrator where he was responsible for leading the development, design, and implementation of the nation's civil space program. Previously, Mr. Scolese served as NASA's Chief Engineer, Deputy Director of the Goddard Space Flight Center, Deputy Associate Administrator in the Office of Space Science at NASA Headquarters, Earth Orbiting Satellite (EOS) Program Manager, and the Deputy Director of Flight Programs and Projects for Earth Science at Goddard. He was selected by Admiral Hyman Rickover to serve at Naval Reactors, where he was associated with the development of instrumentation, instrument systems, and multi-processor systems for the U.S. Navy and the Department of Energy while working for Naval Sea Systems Command. Mr. Scolese is the recipient of several honors, including the Presidential Rank Award of Meritorious Executive, the NASA Distinguished Leadership Medal, Goddard Outstanding Leadership, two NASA Outstanding Leadership Medals, and the American Institute of Aeronautics and Astronautics (AIAA) National Capital Section Young Engineer/Scientist of the Year Award. He is a Fellow of the AIAA and a member of the Institute of Electrical and Electronics Engineers. Mr. Scolese received his Bachelor of Science in electrical engineering from The State University of New York in 1978 and his Master of Science in System Science, Networks and Controls in the Department of Electrical Engineering and Computer Science at GW in 1982. He also received an honorary doctorate degree from the University of Buffalo in 2015.
2018 Hall of Fame Ceremony
GW Engineering Hall of Fame Members (alphabetical listing)
GW Engineering Hall of Fame Members (listing by year)
Distinguished Industry Partner Award
Nominate Someone
SEAS Graduation Information

redpajama_set_name: RedPajamaCommonCrawl


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Newslines is a news network that aims to give readers the complete, interactive news history of any topic. For example, our newsline of Conor McGregor, the UFC fighter, has over 2000 curated and tagged news events. As we add thousands more topics Newslines will become the world's largest curated news archive.
Newslines is built using news from NewsBlocks, a system for converting news articles into unbiased data and storing it on the blockchain, where it cannot be tampered with or censored. Anyone can use NewsBlocks to build trusted news applications, such as news sites, fact checking systems, fake news detectors and voice and chat apps.
Because newslines are built from NewsBlocks' data they can be sorted and filtered. Readers can view each newsline in breaking news view (newest news first) or sort it form oldest news to latest news to give a 'biography view' of the topic. Readers can also filter each newsline to find specific event types, for example to find all of Conor McGregor's legal issues.
Newslines was founded by Mark & Mary Devlin, who are from Glasgow, Scotland. After moving to Japan in 1989, Mark & Mary founded Japan's No 1 English magazine, Metropolis, in 1993. In 2000 they founded japantoday.com, the world's largest news site about Japan in English. They sold their businesses in Japan in 2007, and after spending eight years in the U.S. and 26 years overseas in total, they returned to Scotland in 2016. Click here to read their newsline.
Entrepreneurial Spark
Also in August 2016, Newslines was accepted to Entrepreneurial Spark's Glasgow "Hatchery". Entrepreneurial Spark is the world's largest free business accelerator.
Dell Scot Ignite
In August 2016 Newslines won #DellScotIgnite, a contest for scale-up businesses. Newslines will receive Dell equipment and Mark & Mary are receiving mentoring and support from Dell's UK management team.


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Coin Markets
Tech News 2018-04-30 by admin
What a combined T-Mobile and Sprint would look like
After two earlier attempts failed to materialize, T-Mobile and Sprint announced on Sunday that they've reached a $26.5 billion merger agreement. If approved, it would combine the third and fourth largest carriers in the United States. The new business would instantly become a much more formidable rival to Verizon and AT&T. Both companies claim that a successful merger would make the United States a leader in the formative early years of 5G mobile networks. But there are very legitimate concerns that shrinking the field of wireless competitors could end up hurting consumers and raising prices.
The deal must be cleared by regulators, including both the Federal Communications Commission and Justice Department, which is no small hurdle. FCC…
Bill Gates told Trump that being his science adviser is 'not a good use of my time'
HyperX Now Shipping Predator DDR4 RGB with IR Sync
Copyright © 2019 allcom.se – Designed & Developed by ZThemes.


With more than 1 billion active users, YouTube is the largest video-sharing platform on Earth. If you want to showcase your brand to as many consumers as possible, YouTube is the way to go. Its benefits include an unlimited quantity of high-quality video content uploads, robust analytics, and a user-friendly interface. Its popularity among mobile users and the ability to add interactive call-to-action messages at the end of a video are also key features. Google owns YouTube so if you already have a Google account for your business, you're already connected to an entire digital ecosystem, with support.
Although its primary function is not a video platform, there are a few good reasons to host some of your company's promotional clips on the world's largest social network. Facebook's extensive data mining allows small business owners to specifically target their videos to users who will be most receptive to their message. A recent study found that native Facebook videos get shared 10 times more often than YouTube clips and cost less per 1,000 impressions.
Vimeo is a video-sharing platform that made its name by being the first website of its type to host high definition clips in 2007. Today, it's better known for cultivating a thriving community of talented content creators that attracts 170 million active monthly viewers. Positive aspects of Vimeo are that it's an ad-free platform, features embeddable player customization and in-depth analytics. It also has a premium account option that includes email capture and video production support. Conversely, it has a smaller active viewer base than YouTube and has limitations on the number of videos users can upload. It also charges businesses a minimum $120 a year to host content.


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Home > Sports
Football: Barcelona confirm Aguero signing from Man City
Posted at Jun 01 2021 10:11 AM
Barcelona's new signing Sergio Aguero poses during his presentation. Albert Gea, Reuters
MADRID - Barcelona confirmed that Manchester City striker Sergio Aguero will join the club on 1 July when his contract with the Premier League champions expires.
Argentina international Aguero joined City from Spanish side Atletico Madrid in 2011 and went on to become the club's all-time leading goalscorer, netting 260 times as he helped them to claim five Premier League titles.
"Barcelona are the best team in the world," Aguero, who celebrates his 33rd birthday on Wednesday, told a news conference. "And we all know it.
"It was a good decision to join and help the team achieve things. It's another step and I'm very happy. I hope I can contribute a lot to the club.
"The first thing is to try and play and help the team as much as I can. We are a team, and I will try my best. Hopefully we can get to the end of the season and be in contention for the important trophies."
Barca said the Argentine will sign a two-year deal, with a 100 million euro ($122.04 million) buy-out clause.
Aguero is expected to be the first of a number of arrivals at Camp Nou this summer as new president Joan Laporta looks to revamp a squad that could only finish third in La Liga.
Aguero's City team mate Eric Garcia has been heavily linked as a transfer target by local media, as have Dutch duo Memphis Depay and Georginio Wijnaldum.
(Reporting by Joseph Walker; Editing by Andrew Cawthorne and Christian Radnedge and Pritha Sarkar)
football, Barcelona, Manchester City, Sergio Aguero
Read More: football Barcelona Manchester City Sergio Aguero


We often stress how important it is to record, and store your numerous online account passwords. Complimentary aspect to this is documentation, or a description of how your online systems work. The purpose being so that you both understand your website better, and so that professionals working with your data can understand better how the various parts and features of your website interconnect.
Lately as our client base grows, and clients expand their array of service providers, documentation internally has become key to effectively managing a client's website.
What does this look like? Let me explain. We break a website down into various parts, and basically write notes (in English) that explain how they work, and why they're needed. Here's an example of questions we answer and items we note for email and domains.
External Email (Google Apps, Office365) or Internal?
Other areas of information include DNS, WordPress, WordPress plugins, custom software, third party providers, SSL certificates, databases, and any custom server settings.
DNS: DNS is handled by Cloudflare, where we point the website (A record) to WPEngine and the email (MX) to Google Apps. Cache much be cleared when making changes to static resources (CSS, JS).
While we do this internally for our ongoing maintenance clients, we would also recommend that each client keep in their records, a similar document. Contact us to learn more about the process.


Looking For Indie Devs To Interview On Podcast!
Hey guys! I'm an indie dev on Itch.io and I've recently started a podcast where I talk to game makers, and other creators, usually in the cyberpunk/sci-fi genre (though not necessarily), to spread the word and also to connect with the community. I try to do about one a week, and figure I could help give back to the Itch community where I launched my first initial game by helping promote some of you guys. If you're interested in potentially being on one of these, podcasts, let me know!


I have been looking for a 1993 Ski Nautique for 7 years. 5 years ago I almost bought a rough 1996; but, the furnace went away on my 1906 house. The bill was about the price of the 1996 so I waited. Summer 2015 my wife and I were on a canoe trip in Northern WI and that evening at a friends house I was checking my Craig's list filter and pop came a 1993 and it was 3 miles from my current location. The boat was so perfect and so clean that I didn't even test drive it. Bought it spot on site!
This year I turn 50 and now I am happy!


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The rebate plane (British English) or rabbet plane (American English) is a hand plane designed for cutting rebates/rabbets in wood. It's a simple tool used in many Western countries with hundreds of years of history. It was in use in England at least as early as the 11th century.

The rebate plane is one of a group of planes, including the shoulder plane, bullnose plane and carriage makers plane, in which the blade protrudes by a very small amount—usually less than half a millimetre—from the sides of the plane body on both sides. The blade is very slightly wider than the body of the plane. The reason for the slight protrusion of the blade is so that the plane body does not bind on the side of the cut, which would result in the side wall of the rabbet not being perpendicular to the bottom.

Rebate planes are intended for long grain cutting and are generally set up to remove large amounts of material quickly. The mouth is set quite coarsely to allow large chips to be removed.

There are a few variations of this plane, including the duplex rebate plane, which has two locations for the blade: one in the middle of the body for normal cutting and one at the front to allow cutting into corners. In the latter mode, the duplex rebate plane is similar to a bullnose plane.

The rebate plane commonly has a depth stop and a fence, which allows the width and depth of the rabbet to be gauged. They also are commonly equipped with a spur, which is designed to score the wood as the rabbet is cut, giving a cleaner corner. This is particularly valuable when working across the grain.

References

Planes

redpajama_set_name: RedPajamaWikipedia


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org.drip.state.creator

Class ScenarioDeterministicVolatilityBuilder

java.lang.Object

org.drip.state.creator.ScenarioDeterministicVolatilityBuilder

public class ScenarioDeterministicVolatilityBuilder
extends java.lang.Object

ScenarioDeterministicVolatilityBuilder implements the construction of the basis spline deterministic
        volatility term structure using the input instruments and their quotes.

Author:

Lakshmi Krishnamurthy

Constructor Summary

Constructors

Constructor and Description

ScenarioDeterministicVolatilityBuilder()

Method Summary

All Methods Static Methods Concrete Methods

Modifier and Type
Method and Description

static VolatilityCurve
CubicPolynomialTermStructure(java.lang.String strName,
                            JulianDate dtStart,
                            java.lang.String strCurrency,
                            java.lang.String[] astrTenor,
                            double[] adblImpliedVolatility)

Construct the Deterministic Volatility Term Structure Instance based off of a Cubic Polynomial Spline

static VolatilityCurve
CustomSplineTermStructure(java.lang.String strName,
                         JulianDate dtStart,
                         java.lang.String strCurrency,
                         int[] aiDate,
                         double[] adblImpliedVolatility,
                         SegmentCustomBuilderControl scbc)

Construct the Deterministic Volatility Term Structure Instance using the specified Custom Spline

static VolatilityCurve
FlatForward(int iEpochDate,
           VolatilityLabel label,
           java.lang.String strCurrency,
           double dblFlatVolatility)

Construct the Flat Constant Forward Volatility Forward Curve

static VolatilityCurve
KaklisPandelisTermStructure(java.lang.String strName,
                           JulianDate dtStart,
                           java.lang.String strCurrency,
                           java.lang.String[] astrTenor,
                           double[] adblImpliedVolatility)

Construct the Deterministic Volatility Term Structure Instance based off of a Kaklis-Pandelis
        Polynomial Tension Spline

static VolatilityCurve
KLKHyperbolicTermStructure(java.lang.String strName,
                          JulianDate dtStart,
                          java.lang.String strCurrency,
                          java.lang.String[] astrTenor,
                          double[] adblImpliedVolatility,
                          double dblTension)

Construct the Deterministic Volatility Term Structure Instance based off of a KLK Hyperbolic Tension
        Spline

static VolatilityCurve
KLKRationalLinearTermStructure(java.lang.String strName,
                              JulianDate dtStart,
                              java.lang.String strCurrency,
                              java.lang.String[] astrTenor,
                              double[] adblImpliedVolatility,
                              double dblTension)

Construct the Deterministic Volatility Term Structure Instance based off of a KLK Rational Linear
        Tension Spline

static VolatilityCurve
KLKRationalQuadraticTermStructure(java.lang.String strName,
                                 JulianDate dtStart,
                                 java.lang.String strCurrency,
                                 java.lang.String[] astrTenor,
                                 double[] adblImpliedVolatility,
                                 double dblTension)

Construct the Deterministic Volatility Term Structure Instance based off of a KLK Rational Quadratic
        Tension Spline

static VolatilityCurve
QuarticPolynomialTermStructure(java.lang.String strName,
                              JulianDate dtStart,
                              java.lang.String strCurrency,
                              java.lang.String[] astrTenor,
                              double[] adblImpliedVolatility)

Construct the Deterministic Volatility Term Structure Instance based off of a Quartic Polynomial
 `Spline

Methods inherited from class java.lang.Object

equals, getClass, hashCode, notify, notifyAll, toString, wait, wait, wait

Constructor Detail

ScenarioDeterministicVolatilityBuilder

public ScenarioDeterministicVolatilityBuilder()

Method Detail

CustomSplineTermStructure

public static final VolatilityCurve CustomSplineTermStructure(java.lang.String strName,
                                                              JulianDate dtStart,
                                                              java.lang.String strCurrency,
                                                              int[] aiDate,
                                                              double[] adblImpliedVolatility,
                                                              SegmentCustomBuilderControl scbc)

Construct the Deterministic Volatility Term Structure Instance using the specified Custom Spline

Parameters:

strName - Name of the the Term Structure Instance

dtStart - The Start Date

strCurrency - Currency

aiDate - Array of Dates

adblImpliedVolatility - Array of Implied Volatility Nodes

scbc - Segment Custom Builder Parameters

Returns:

Instance of the Term Structure

CubicPolynomialTermStructure

public static final VolatilityCurve CubicPolynomialTermStructure(java.lang.String strName,
                                                                 JulianDate dtStart,
                                                                 java.lang.String strCurrency,
                                                                 java.lang.String[] astrTenor,
                                                                 double[] adblImpliedVolatility)

Construct the Deterministic Volatility Term Structure Instance based off of a Cubic Polynomial Spline

Parameters:

strName - Name of the the Term Structure Instance

dtStart - The Start Date

strCurrency - Currency

astrTenor - Array of Tenors

adblImpliedVolatility - Array of Implied Volatility Nodes

Returns:

The Deterministic Volatility Term Structure Instance based off of a Cubic Polynomial Spline

QuarticPolynomialTermStructure

public static final VolatilityCurve QuarticPolynomialTermStructure(java.lang.String strName,
                                                                   JulianDate dtStart,
                                                                   java.lang.String strCurrency,
                                                                   java.lang.String[] astrTenor,
                                                                   double[] adblImpliedVolatility)

Construct the Deterministic Volatility Term Structure Instance based off of a Quartic Polynomial
 `Spline

Parameters:

strName - Name of the the Term Structure Instance

dtStart - The Start Date

strCurrency - Currency

astrTenor - Array of Tenors

adblImpliedVolatility - Array of Implied Volatility Nodes

Returns:

The Deterministic Volatility Term Structure Instance based off of a Quartic Polynomial Spline

KaklisPandelisTermStructure

public static final VolatilityCurve KaklisPandelisTermStructure(java.lang.String strName,
                                                                JulianDate dtStart,
                                                                java.lang.String strCurrency,
                                                                java.lang.String[] astrTenor,
                                                                double[] adblImpliedVolatility)

Construct the Deterministic Volatility Term Structure Instance based off of a Kaklis-Pandelis
        Polynomial Tension Spline

Parameters:

strName - Name of the the Term Structure Instance

dtStart - The Start Date

strCurrency - Currency

astrTenor - Array of Tenors

adblImpliedVolatility - Array of Implied Volatility Nodes

Returns:

The Deterministic Volatility Term Structure Instance based off of a Kaklis-Pandelis Polynomial
        Tension Spline

KLKHyperbolicTermStructure

public static final VolatilityCurve KLKHyperbolicTermStructure(java.lang.String strName,
                                                               JulianDate dtStart,
                                                               java.lang.String strCurrency,
                                                               java.lang.String[] astrTenor,
                                                               double[] adblImpliedVolatility,
                                                               double dblTension)

Construct the Deterministic Volatility Term Structure Instance based off of a KLK Hyperbolic Tension
        Spline

Parameters:

strName - Name of the the Term Structure Instance

dtStart - The Start Date

strCurrency - Currency

astrTenor - Array of Tenors

adblImpliedVolatility - Array of Implied Volatility Nodes

dblTension - Tension

Returns:

The Deterministic Volatility Term Structure Instance based off of a KLK Hyperbolic Tension
        Spline

KLKRationalLinearTermStructure

public static final VolatilityCurve KLKRationalLinearTermStructure(java.lang.String strName,
                                                                   JulianDate dtStart,
                                                                   java.lang.String strCurrency,
                                                                   java.lang.String[] astrTenor,
                                                                   double[] adblImpliedVolatility,
                                                                   double dblTension)

Construct the Deterministic Volatility Term Structure Instance based off of a KLK Rational Linear
        Tension Spline

Parameters:

strName - Name of the the Term Structure Instance

dtStart - The Start Date

strCurrency - Currency

astrTenor - Array of Tenors

adblImpliedVolatility - Array of Implied Volatility Nodes

dblTension - Tension

Returns:

The Deterministic Volatility Term Structure Instance based off of a KLK Rational Linear
        Tension Spline

KLKRationalQuadraticTermStructure

public static final VolatilityCurve KLKRationalQuadraticTermStructure(java.lang.String strName,
                                                                      JulianDate dtStart,
                                                                      java.lang.String strCurrency,
                                                                      java.lang.String[] astrTenor,
                                                                      double[] adblImpliedVolatility,
                                                                      double dblTension)

Construct the Deterministic Volatility Term Structure Instance based off of a KLK Rational Quadratic
        Tension Spline

Parameters:

strName - Name of the the Term Structure Instance

dtStart - The Start Date

strCurrency - Currency

astrTenor - Array of Tenors

adblImpliedVolatility - Array of Implied Volatility Nodes

dblTension - Tension

Returns:

The Deterministic Volatility Term Structure Instance based off of a KLK Rational Quadratic
        Tension Spline

FlatForward

public static final VolatilityCurve FlatForward(int iEpochDate,
                                                VolatilityLabel label,
                                                java.lang.String strCurrency,
                                                double dblFlatVolatility)

Construct the Flat Constant Forward Volatility Forward Curve

Parameters:

iEpochDate - Epoch Date

label - Forward Volatility Label

strCurrency - Currency

dblFlatVolatility - Flat Volatility

Returns:

The Volatility Curve Instance

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text:
Newsletter and Annoucements
Mon, 05/01/2017 - 8:04am By Nicky Chavez
Submitted by Nicky Chavez on Mon, 05/01/2017 - 12:07pm
New Accomplishments:
We would like to congratulate Gina Jensen on her accomplishments. Gina has been working at 5-County Y0uth Treatment Center since 2006. In 2009 she was promoted to Case Manager. Gina attended Idaho State University and graduated with a minor in Criminal Justice. She then attended Brigham Young University Idaho and earned her Bachelors in Social Work. She recently took the State boards and earned her LSW for the State of Idaho. Gina loves working with kids and making a difference in their lives. Her hobbies are camping, fishing, hunting, spoiling other people's children, working in her yard and enjoys all activities that are outdoors. Congratulations Gina!
The Five County traditions for the holidays have come and gone and fun was had by all. There was a Halloween party complete with pumpkin painting contests. Thanksgiving dinner was prepared by our wonderful kitchen cooks. They served roasted turkey, mashed potatoes and gravy, sweet potatoes, relish trays, homemade rolls, pumpkin pie and whip cream and everyone enjoyed all the hard work they put into it! Christmas was another feast and residents enjoyed all the activities that come along with it, such as waking up Christmas morning to find stockings full of surprises.
Welcome, Welcome!
We are so proud to announce an addition to our management team Alice Manwaring has joined us as our clinician. Ironically she had worked for us in 2010 and then decided to pursue her education. Alice earned her Bachelor in Sociology degree at Brigham Young University Idaho. She then attended Walla Walla University and earned her Master's in Social Work. She came to us because she needed something more challenging and that is definitely something we have here! She has always has enjoyed the Criminal Justice Field. She enjoys working with the teenage population and loves to assist them in empowering themselves and building their confidence. Away from work, Alice enjoys camping, spending time with family, weightlifting, archery and range shooting and laughing and loving life! We are so excited to have her on our team!
5-C has been blessed to have our "Friends" come and Speak to the Youth at our Center. Three of the most sought aftever motivational speakers visisted the Center recently-Rulan Garnder, L.T .Smoothe, and Monte Stiles. On behalf of the kids and staff we say "Thank You" for all the tremendous work you do and forever touching our lives!!! Thank you Jennifer Peterson for sharing your amazing story and ecouraging us to love ourselves inside and out. You are all are always welcome at 5-C.
L.T. Smoothe
Another year and another visit from the great LT Smoothe. L.T. visited with the residents and shared his amazing story. L.T. started out with a life of violence, crime , gangs and drugs. One day he decided that was not was he was meant to be on the earth and changed his life. He taught himself to play instruments and is an incredible solo guitar player, singer and song writer who has played with some of the greatest musicians and for many famous people and has been nominated for the Grammy Awards. He now has a mission to facilitate change with others. He is now the Voice for Change. His goal is to reach as many people as possible who are on the edge of dying from depression, suicide, drugs, alcohol, and violence and have no more hope in them. He brings hope and love and joy and surrenders his own life to save theirs. He states, it only takes a moment to listen to a cry sometimes that is all it takes. His hands are open wide and his heart is bigger than the ocean. L.T. and his team are working hard to fulfill this dream. He is an inspiration to all of us here at 5-County and we appreciate his visits so much. Thank you L.T.! Thanks Donna Benfield (CEO Rexburg Chamber of Commerce), Ken Benfield & Mountain America Credit Union for making it possible for L.T. to visit our Center and the East Idaho Community.
Rulan Gardner
Another visitor that came by to say hi again was two time Olympic wrestler Rulan Gardner. Rulan started as a small town Wyoming "boy" who has overcome huge challenges in his life and came out on top. During the peak of his wrestling career he was in a snow machine accident and stranded in freezing weather. He went through a harrowing recovery after frostbite and almost losing his life. Despite these trials he went on to win an undefeated Russian wrestler and won his second Olympic medal. He also made it through a plane accident in a lake!!!! He speaks to all about perseverance and never giving up on your dreams. We appreciate his willingness to continue visiting us at 5-County and sharing his incredible journey. Thank you Rulan!
Monte Stiles
We had the honor of having Monte Stiles come speak to us at the center. You can't help but feel his passion! One of his proudest personal and career achievements was the organization and implementation of the statewide "Enough is Enough" anti-drug campaign which produced community coalitions in every area of Idaho. In addition to the prosecution of drug traffickers, Monte has been a passionate drug educator and motivational speaker for schools, businesses, churches, law enforcement agencies, and other youth and parent organizations. He loves the youth and the youth definitely felt it! A Special thanks to Fremont County Chief Probation Officer Darin Burrell for assisting to cordinate scheduling our forever friend Monte Stiles to come and be part of the Center. I would encourage everyone to visit Monte's webpage atwww.montestiles.com. Monte is an inspiration to all those he comes in contact with.
Jennifer Peterson:
Another great visitor we had to the center was Jennifer Peterson. She grew up in Okayama Japan and Edmonton, Alberta, Canada. She spent her youth modeling, playing the saxophone and running track, as well as playing volleyball and basketball. She played two years of college basketball after high school and continued her studies in Special Education. She left to serve a church mission in Sapporo, Japan for eighteen months and then returned to BYUI to finish her degree. After returning from her mission, she took up photography as she preferred to be on the other side of the camera. Jennifer was VERY TALL through her school years and had to withstand a lot of bullying and it greatly affected her self-esteem growing up. Despite these struggles, she became a very successful model and photographer and learned to love herself inside and out. She now spreads her story to young women everywhere to encourage them to love their selves and follow their dreams. The girls at the center loved her visit and hope she comes to visit them again to see how much they have grown since coming into treatment at Five County.
New Grant news:
One of the highlights of Five County's curriculum is our parenting class. In 2002 we received our first grant for Baby Think It Over simulator dolls from the Idaho Children's Trust Fund. The dolls came with all the equipment needed (carriers, bottles, diapers and diaper bags) for a realistic experience of what it is like to care for an infant 24 hours a day. Then center continued to get grants the next two years. One grant purchased a "fetal alcohol" and a "drug affected" doll. The next grant purchased 4 actual "pregnancy simulator" suits. This equipment has been used year after year for many, many youth to learn about what it takes to be a parent along with two weeks of classroom curriculum and then five days of caring for the infants. The center has been very proud of this program which was implemented by Taryn Ivie.
After many years, the babies and equipment were wearing out. Last year Marilee Wigginton, our head education teacher wrote a grant for the Idaho Children's Trust Fund for new equipment. We were awarded $3, 102 dollars and along with more funds from the center we were able to purchase six new updated
Last year we were awarded $3,102.00 in grant money from the Idaho Children's Trust Fund to purchase six new Baby Think It Over dolls and all the equipment for our parenting class as well as updated curriculum. The grant money paid for over half the costs! Marilee applied again this year and was awarded grant money again, this time to expand our curriculums for the parenting class and other classes to include the "Five Protective Factor" which is education for the residents to help overcome adverse childhood experiences. The management team has been trained on the new curriculum and training will soon be implemented to the treatment team. Thank you Idaho Children's Trust Fund and thank you Marilee for this great addition to the center.
Fun Outings:
Everyone loves a good field trip and that is exactly what some of the residents were able to do this month. They were able to visit the Idaho Falls museum. The theme was the Roman empires and their machines and architecture. They then went down to the lower level of the museum and were able to see the display of an early pioneer town. It was a great experience. They were then able to go to lunch at Pizza Pie Café to top off the day. A fun time was had by all.


text:
Omics score: 2
Transcription profiling of human primary hepatocytes treated with acetaminophen in sandwich-cultured cells
ABSTRACT: Gene expression profiles of sandwich-cultured primary human hepatocytes exposed to 5 mM and 10 mM acetaminophen were used in a parallelogram approach in order to compare gene expression responses between rat and human using in vitro cellular models, hepatocytes, and between rat in vitro and in vivo. Experiment Overall Design: Samples were retrieved from acetaminophen treated human hepatocyte cultures from 5 individuals (5 biological replicates). Experiment Overall Design: Human hepatocytes from each replicate were treated with 0, 5, and 10 mM acetaminophen for 24 h. Experiment Overall Design: This resulted in (3x5) 15 dual channel arrays on which control (0 mM acetaminophen) and reference samples (0, 5, and 10 mM acetaminophen) were hybridized.
SUBMITTER: Anne Susan Kienhuis
Transcription profiling of rat primary hepatocytes after acetaminophen-induced gene expression in sandwich-culture
Project description:Gene expression profiles of sandwich-cutlured primary rat hepatocytes exposed to 5 mM and 10 mM acetaminophen were used in a parallelogram approach in order to compare gene expression responses between rat and human using in vitro cellular models, heaptocytes, and between rat in vitro and in vivo Experiment Overall Design: Samples were retrieved from acetaminophen treated rat hepatocyte cultures from 3 rats (3 biological replicates). Rat hepatocytes from each replicate were cultured in two culture conditions, each treated with 0, 5, and 10 mM acetaminophen for 24 h. This resulted in (3 rats x 2 culture conditions x 3 doses) 18 dual channel arrays on which control (0 mM acetaminophen) and reference samples (0, 5, and 10 mM acetaminophen) were hybridized
A Genomics-Based Analysis of Relative Potencies of Dioxin-Like Compounds in Primary Rat Hepatocytes
Project description:A toxicogenomics approach was used to qualitatively and quantitatively compare gene expression changes in rat primary hepatocytes exposed to 2,3,4,7,8-pentachlorodibenzofuran (4-PeCDF) or 2,3,7,8-tetrachlorodibenzofuran (TCDF). Hepatocytes from five individual rats were exposed for 24 hours to 11 concentrations of each chemical ranging from 0.00001 nM to 100 nM and a vehicle control. 115 microarrays representing primary hepatocytes from 5 rats, each exposed to 11 doses of each chemical (PeCDF and TCDF) and vehicle controls. Arrays were completed with a one-color design.
Genome-wide gene expression profiles of primary hepatocytes in two different culture systems over an 8-day period
Project description:The liver is one of most important organs in our bodies. It performs many essential functions including metabolism, synthesis, secretion, detoxification, and storage. Hepatocytes are the principal cell type in the liver and are involved in multiple liver-specific functions. There have been several efforts to develop in vitro culture systems capable of maintaining hepatocyte-specific phenotype over long time periods. In hepatic tissue engineering, two commonly used culture systems are the collagen sandwich and monolayers of cells. 'àö√ᬨ'ĆIn this study, genome-wide gene expression profiles of primary hepatocytes were measured over an 8-day period for each cell culture system using Affymetrix GeneChips and analyzed via Gene Set Enrichment Analysis (GSEA), which is a powerful method to elicit biologically meaningful information from microarray data at the level of gene sets. Results indicate that the gene expression in hepatocytes in collagen sandwich cultures gradually diverges from that in monolayer cultures. Gene sets up-regulated in collagen sandwich cultures include those associated with liver metabolic and synthetic functions. 'àö√ᬨ'ĆThese functions are associated with lipid, amino acid, carbohydrate, and alcohol metabolism and bile acid synthesis. Nuclear receptors are up-regulated in collagen sandwiches 24 hours after seeding. Signals transmitted from these receptors may cause the up-regulation of other processes in subsequent days. Cytochrome-P450 monooxygenase expression was initially down-regulated but exhibited up-regulation after 72 hours. Our results provide a baseline for further explorations into the systems biology of engineered liver mimics as well as 2D and 3D co-cultures of primary hepatocytes and non-parenchymal cells. To better understand differences in quality of in vitro growth of rat hepatocytes between culture on a monolayer of collagen gel and sandwiched between two layers of gel, we measured gene expression in hepatocytes in these two culture conditions in triplicate for four time points: 1 day, 2 days, 3 days, and 8 days of culturing. Overall, we obtained Affymetrix microarray data for 24 samples, divided to 12 samples from monolayer and double layer cultures each, each of which are divided into four time points with 3 sample replicates.
Regulation of microRNA expression by rifampin in human hepatocytes
Project description:Rifampin causes drug interactions by altering hepatic drug metabolism. Because microRNAs (miRNAs) have been shown to regulate genes involved in drug metabolism, we determined the effect of rifampin on the expression of hepatic miRNAs. Primary human hepatocytes from seven subjects were treated with rifampin, and the expression of miRNA and cytochrome P450 (P450) mRNAs was measured by TaqMan assays and RNA-seq, respectively. Rifampin induced the expression of 10 clinically important and 13 additional P450 genes and repressed the expression of 9 other P450 genes (P < 0.05). Rifampin induced the expression of 33 miRNAs and repressed the expression of 35 miRNAs (P < 0.05). Several of these changes were highly negatively correlated with the rifampin-induced changes in the expression of their predicted target P450 mRNAs, supporting the possibility of miRNA-induced regulation of P450 mRNA expression. In addition, several other miRNA changes were positively correlated with the changes in P450 mRNA expression, suggesting similar regulatory mechanisms. Despite the interindividual variability in the rifampin effects on miRNA expression, principal components analysis clearly separated the rifampin-treated samples from the controls. In conclusion, rifampin treatment alters miRNA expression patterns in human hepatocytes, and some of the changes were correlated with the rifampin-induced changes in expression of the P450 mRNAs they are predicted to target. Primary human hepatocytes were treated rifampin or vehicle for 24 hours. Rifampin-treated samples are not available for the 30Jul10 patient or the Hep2 patient due to raw data file corruption.
2015-09-15 | E-GEOD-20659 | ExpressionAtlas
Transcription profiling of primary mouse hepatocytes under different culture conditions
Project description:It is well-known that isolation and cultivation of primary hepatocytes causes major gene expression alterations. In the present genome-wide, time resolved study of cultivated human and mouse hepatocytes, we made the observation that expression changes in culture strongly resemble alterations in liver diseases. Hepatocytes of both species were cultivated in collagen sandwich and in monolayer conditions. Genome-wide data were also obtained from human NAFLD, cirrhosis, HCC, and hepatitis B virus infected tissue as well as mouse livers after partial hepatectomy, CCl4 intoxication, obesity, HCC and LPS. A strong similarity between cultivation and disease induced expression alterations was observed. For example, expression changes in hepatocytes induced by one day cultivation and one day CCl4 exposure in vivo correlated with R=0.615 (P<0.001). Interspecies comparison identified predominantly similar responses in human and mouse hepatocytes but also a minority of genes that responded differently. Unsupervised clustering of altered genes identified three main clusters: (1) downregulated genes corresponding to mature liver functions, (2) upregulation of an inflammation/RNA-processing cluster, (3) upregulated migration/cell-cycle associated genes. Gene regulatory network analysis highlights overrepresented and deregulated HNF4 and CAR (cluster 1), Krüppel-like factors MafF and ELK1 (cluster 2) as well as ETF (cluster 3) among the interspecies conserved key regulators of expression changes. Interventions ameliorating but by far not abrogating cultivation-induced responses include removal of non-parenchymal cells, generation of the hepatocytes' own matrix in spheroids, supplementation with bile salts and siRNA mediated suppression of key transcription factors. In conclusion, the study shows that gene regulatory network alterations of cultivated hepatocytes resemble those of inflammatory liver diseases and should therefore be considered and exploited as disease models.
2016-09-28 | E-MTAB-4444 | ArrayExpress
RNA-seq of Primary Human Hepatocytes (PHH) exposed to Valproic Acid (VPA) for 3 days daily and 3 days daily exposure followed by 3 days washout.
Project description:Primary Human Hepatocytes (PHH) were exposed daily for 3 days to 15 mM VPA after which RNA was isolated. After terminating the VPA treatment, part of the cells were kept with medium for 3 days in order to investigate the eventual persistence of VPA-induced methylome changes. Identification of differentially expressed regions in the RNA was carried out by the RNA-seq method.
The Hepatocyte Proteome in Organotypic Rat Liver Models and the Influence of the Local Microenvironment
Project description:Liver models that closely mimic the in vivo microenvironment are central for understanding liver functions, capabilities, and intercellular communication processes. Whereas hepatocyte monolayers de-differentiate after only a few days in culture, constructs consisting of hepatocytes and non-parenchymal cells (NPC) separated by a polyelectrolyte multilayer (PEM) provide maintenance of hepatic phenotypes. To better understand the mechanisms and processes that underlie organotypic liver model function, hepatocyte protein abundances in the presence and absence of liver sinusoidal endothelial cells (LSECs) were compared to hepatocyte monolayers. The presence of the PEM led to increases in proteins associated with hepatocyte lipid metabolism, with mitochondrial-based β-oxidation and peroxisomal proteins found in higher abundance. It was also demonstrated that the presence of LSECs modulates levels of carboxylesterases and other phase I and phase II enzymes. These results are discussed in relation to intercellular signaling and hepatocyte function.
MeDIP profiling by high-throughput sequencing of Primary Human Hepatocytes (PHH) exposed to Valproic Acid (VPA) for 3 days daily and 3 days daily exposure followed by 3 days washout.
Project description:Primary Human Hepatocytes (PHH) were exposed daily for 3 days to 15 mM VPA after which DNA was isolated. After terminating the VPA treatment, part of the cells were kept with medium for 3 days in order to investigate the eventual persistence of VPA-induced methylome changes. Identification of methylated regions in the DNA was carried out by the Methylated DNA Immuno-Precipitation - sequencing (MeDIP-seq) method and contains the following steps: fragmentation, library preparation, MeDIP, and sequencing.
Generation of integration-free induced hepatocytes from mouse fibroblasts
Project description:Previous studies demonstrated that hepatocyte-specific transcription factors could directly convert fibroblasts into functional hepatocytes-like cells, namely induced hepatocytes (iHeps) using viral systems. However, viral integration into host genome causes insertional mutation and risk of tumorigenecity. we showed iHeps could be generated from MEFs using the integration-free system. They were expandable in vitro and showed hepatic features, similar to primary hepatocytes. iHeps_G4H1F3 transfected (Episomal vectors) and iHeps_G4H1F3 transduced (pMXs) were duplicate, respectively. MEFs and primary hepatocytes were used as negative and positive controls, respectively.


Hibbett Sporting Goods (Varsity Lettering) can be found at 1318 1st Avenue North . The following is offered: Clothing Stores, Other Footwear, Sporting Goods, Footwear Wholesalers . In Birmingham there are 108 other Clothing Stores. An overview can be found here.


text:
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Home / Articles / American Ships Sunk at Pearl Harbor
American Ships Sunk at Pearl Harbor
October 20, 2016 By: Tara Tyrrell
There were 100 commissioned warships and service auxiliary ships that were present at Pearl Harbor on the morning of December 7, 1941, when the Japanese attacked. Although only 16 of those 100 were damaged, it was the amount of damage to the most significant of the ships that left the biggest mark. Here are the ships that were sunk at Pearl Harbor.
USS Arizona and USS Oklahoma
Two of the fleet were lost forever, with the two battleships USS Arizona (BB-39) and USS Oklahoma (BB-37) being sunk in the initial attack. Arizona exploded and sank after a bomb detonated in a powder magazine, killing 1,177 officers and crewmen, and the Oklahoma was sunk by several torpedoes during the attack and 429 crew died when she capsized on Battleship Row.
The USS Nevada
The USS Nevada (BB-36) was the only battleship to get underway during the attack, but she was hit by one torpedo and at least six bombs while steaming away from Battleship Row, forcing her to be beached at Hospital Point.
The Nevada was refloated and repaired, and later served as a convoy escort in the Atlantic and as a fire-support ship in four amphibious assaults. At the end of World War II, the Navy assigned her to be a target ship in the atomic experiments conducted at Bikini Atoll, and she was finally retired in 1946 and sunk during naval gunfire practice in 1948.
Eliminating the battleships
During the attack, the Japanese had a key focus on eliminating the battleships, as they were one of the biggest threats to the internal affairs of Japan and their campaigns for conquering Manchuria.
Stealthy Japanese planning permitted the attack on Pearl Harbor to remain undetected by US intelligence, and in the days before the attack, Japanese destroyers and battleships had led fighters, dive-bombers, high-level bombers, and torpedo planes into position to the north of the Hawaiian Islands.
Upon reaching Pearl Harbor on the morning of December 7, the torpedo bombers that had travelled in complete radio silence attacked the harbor in groups of twos and threes in a surprising, quick and powerful attack, with the second fleet of Japanese aircraft blitzing the site an hour later.
USS California
A number of other boats were sunk in the attack, but later recovered and repaired. The USS California (BB-44) lost 100 crew members that morning, after the ship suffered extensive flooding damage when hit by two torpedoes on the port side. Both torpedoes detonated below the armor belt causing virtually identical damage each time. A 250 kg bomb also entered the starboard upper deck level, which passed through the main deck and exploded on the armored second deck, setting off an anti-aircraft ammunition magazine and killing about 50 men.
After three days of flooding, the California settled into the mud with only her superstructure remaining above the surface. She was later re-floated and dry-docked at Pearl Harbor for repairs. USS California served many missions throughout the war, and was eventually decommissioned in February, 1947.
USS West Virginia
USS West Virginia (BB-48) was sunk by six torpedoes and two bombs during the attack on Pearl Harbor, but in May 1942, was salvaged from the seabed by draining the water from the hull.
USS Cassin and USS Downes
USS Cassin (DD-372) and USS Downes (DD-375) were Mahan-class destroyers. The two destroyers were in dry-dock at Pearl Harbor during the attack, when an incendiary bomb ignited fuel tanks on Downes. Cassin slipped from her keel blocks and rested against Downes which were both destroyed by uncontrollable fires. Both ships were considered lost, but their machinery and equipment were salvaged and sent to Mare Island Navy Yard where entirely new ships were built around the salvaged material and given the wrecked ships' names and hull numbers.
USS Oglala
USS Oglala (ID-1255/CM-4/ARG-1) was a minelayer and was the flagship of the Pacific Fleet Mine Force. Japanese torpedo planes of the first attack surge hit the cruiser with a single torpedo, and Oglala rapidly took on water and sank. She was later salvaged in 1942 and continued service until 1965 (after being redesignated as an internal combustion engine repair ship ARG-1).
Many other ships were damaged in the attack, and many lives were lost. The salvageable ships that were recommissioned all played a big part in the remaining years of World War II and many missions after that.
The Hospital Ship USS Solace
For 14 years, the SS Iroquois sailed the world's waters...
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Procopius, born at Caesarea in Palestine late in the 5th century, became a lawyer. In A.D. 527 he was made legal adviser and secretary of Belisarius, commander against the Persians, and went with Belisarius again in 533 against the Vandals and in 535 against the Ostrogoths. Sometime after 540 he returned to Constantinople. He may have been that Procopius who was prefect of Constantinople in 562, but the date of his death (after 558) is unknown.Procopius' History of the Wars in 8 books recounts the Persian Wars of emperors Justinus and Justinian down to 550 (2 books); the Vandalic War and after-events in Africa 532-546 (2 books); the Gothic War against the Ostrogoths in Sicily and Italy 536-552 (3 books); and a sketch of events to 554 (1 book). The whole consists largely of military history, with much information about peoples and places as well, and about special events. He was a diligent, careful, judicious narrator of facts and developments and shows good powers of description. He is just to the empire's enemies and boldly criticises emperor Justinian. Other works by Procopius are the Anecdota or Secret History-vehement attacks on Justinian, Theodora, and others; and The Buildings of Justinian (down to A.D. 558) including roads and bridges as well as churches, forts, hospitals, and so on in various parts of the empire.The Loeb Classical Library edition of Procopius is in seven volumes. The most famous woman of late antiquity, the empress Theodora, is portrayed with a very sharp pen in Procopius' Secret History. The 6th century historian here sets out to tell "what manner of persons Justinian and Theodora were and the method by which they ruined the Roman Empire"--in an account that he apparently meant to publish after their deaths. He tells of Theodora's early years as a stage performer and prostitute; the duplicitous means and intrigue she employed to achieve her goals when in power; her cruelty and spite, vanity and pride. Not a fair and balanced picture perhaps, but a striking and vivid one.


Sport loop has hinges found on either side of the loop that work with gravity and swivel in every direction, moving with the wearer. Glasses stay securely in the loop, flat against you and at your finger tips.
me from losing and replacing all the time.
Other use beside a glass holder.
I love it. I am a petite woman, so I wanted to use it for my ID badge at work. It works perfect!
PLEASE BRING THE COLORS BACK!
I have purchased two LaLoops. (Navy & Black) I'd love to have one or two more in cheery bright colors, too. I like the stretchy and washableand washable feature.
I loved my first one so I bought another. Would love the colors. Still only black???


text:
Q: How to load my angular app correctly with electron throu file:///? I have a simple Angular app and it is in www folder of my project. It works ok in browser when I run it through http:// server or virtual host. But index.js loads this as file
mainWindow.loadUrl('file://' + __dirname + '/www/index.html');

So when I pun electron . it shows blank window. I tried to open my index.html in a Chrome browser through file:/// and it is also blank. The error in console

XMLHttpRequest cannot load file:///Users/Sergey/Sites/Electron-test/www/partials/layout.html. Cross origin requests are only supported for protocol schemes: http, data, chrome, chrome-extension, https, chrome-extension-resource.(anonymous function) @ angular.js:10722

This is because on router ui
$stateProvider.state("app", {
    url: '/',
    templateUrl: 'partials/layout.html'
});

There are some other same errors for images.
I guess there are 2 solutions to that.

*

*Run server with node and change loadUrl('file:///...') to loadUrl('http:///...') but I have no idea how to do that.

*Do something else. May be some header or parameter to allow cross origin requests and I have no idea how to do that.

How can I solve this problem?

A: After some time i have figured out how to do this and now Electron builds app and it runs perfectly. Here is the whole index.js consumed by electron as starting point.
'use strict';
var http = require('http');
var path = require('path');
var fs = require('fs');
var app = require('app');
var BrowserWindow = require('browser-window');

require('crash-reporter').start();

var mainWindow = null;

app.on('window-all-closed', function() {
    if(process.platform != 'darwin') {
        app.quit();
    }
});

app.on('ready', function() {
    mainWindow = new BrowserWindow({
        width: 800,
        height: 600
    });

    var server = http.createServer(requestHandler).listen(9527);

    mainWindow.loadUrl('http://localhost:9527/index.html');
    mainWindow.webContents.on('did-finish-load', function() {
        mainWindow.setTitle(app.getName());
    });
    mainWindow.on('closed', function() {
        mainWindow = null;
        server.close();
    });
});

function requestHandler(req, res) {
    var
        file    = req.url == '/' ? '/index.html' : req.url,
        root    = __dirname + '/www',
        page404 = root + '/404.html';

    getFile((root + file), res, page404);
};

function getFile(filePath, res, page404) {

    fs.exists(filePath, function(exists) {
        if(exists) {
            fs.readFile(filePath, function(err, contents) {
                if(!err) {
                    res.end(contents);
                } else {
                    console.dir(err);
                }
            });
        } else {
            fs.readFile(page404, function(err, contents) {
                if(!err) {
                    res.writeHead(404, {'Content-Type': 'text/html'});
                    res.end(contents);
                } else {
                    console.dir(err);
                }
            });
        }
    });
};

This is a starting point. All you have to do is change root parameter to indicate your index.html root folder. But I am sure if you build universal app, it is going to be www.

redpajama_set_name: RedPajamaStackExchange


Throngs of mourners have filed past the coffin of Adolfo Suarez, the statesman who led Spain to democracy after the four-decade Franco dictatorship.
Some 30,000 people have flocked to the lower house of parliament in Madrid where Suarez's flag-drapped coffin has been lying in state since Monday at noon, the president of the parliament, Jesus Posada, told reporters.
"What people want are people like Adolfo Suarez, who work for Spain," he said before the doors to parliament were closed at 10:00 am on Tuesday ahead of Suarez's funeral.
The queue stretched at one point for up to five kilometres (three miles) from the doors of the lower house of parliament as mourners waited in the cold and rain for hours to bid farewell to the late prime minister, who died on Sunday aged 81.
The former prime minister's coffin will be moved later on Tuesday morning to Avila where he will be buried in the city's cathedral.
Suarez, Spain's first elected premier after the death of the dictator Francisco Franco in 1975, died in a Madrid hospital after suffering from Alzheimer's disease for the past decade.
He had been admitted March 17 with pneumonia.
Suarez was a leading player in the delicate dismantling of the dictatorship followed by democratic reforms that he and King Juan Carlos helped to achieve after Franco died -- a process known as the "transition".
A state funeral will be held on March 31 in Madrid's Almudena Cathedral.


I'm ... (marital status = situation de famille : married, single, divorced, widow (f), widower (m)).
What's your name ? - Where do you live?
Do you have any child ? - How many kids (children) do you have?
How many ? / How much ?
What ? / What ... for? / What .... like?
__________ companies have you worked in ?
__________ of the two offices do you prefer ?
__________ did you arrived in Tokyo ?
__________ is the nearest station ?
__________ is the CEO ?
__________ do you work for ?
__________ didn't you call a taxi ?
_________ are you here for ?
_________ is your assistant like ?
_________ is your appointment with ? The personnel manager.
_________ did you get here ? This morning.
_________ will you meet ? The other trainees.
_________ will you discuss ? The training and the salary !
________ do you need a recorder _____ ? To record each one of his words and promises !
_________ does the meeting take place ? On the second floor.
________ documents do you need, this one or the other one ?
________ was the meeting _______ ? Great !
Comment employer « be » ?
Is Kate a nice girl ?
Is she helping her sister ?
Is she / he / it ?
You are always complaining ! What's wrong with you ?
I'm really tired and nobody is helping me with the housework !
No, that's true. You're always watching television !
Si vous aviez à traduire les phrases suivantes, quoi utiliseriez-vous ?
At the restaurant, she (always sits/is always sitting) at the same table.
He (buys/is buying) a new car every year.
Look at this photo ! Everybody (smiles/is smiling) on it.
Here the wind (blows/is blowing) seven days a week !
I (don't spend/am not spending) my holidays in this horrible place any more.
Comment employer « have » ?
Has she / he / it ?
Where would you like to ___________________ ?
At the Indian or Italian restaurant ?
Can I _________________ at your book ? It looks interesting.
We always ________________ in summer.
I love this car ! It runs very fast ! _____________ if you want to.
Okay, then see you tomorrow, ___________________ !
Your motorcycle looks so easy, can ______________ ?
Comment employer « do » ?
He isn't doing his homework now.
When does he do his homework ?
Do you really like him ?
The detective ________ interviewing a suspect but the man _______ want to answer the questions.
What sort of books ______ you read ? ______ you like science_fiction ?
I ________ got lots of DVDs but I _________ have much time to watch them.
She ________ shouting all the time ! ________ she has a problem ?
My parents _________ have enough money to buy a new car, that's why we ________walking to school.
Does she / he / it ?


Occasionally CNN or one of the other 24 news channels makes a morning debut when there is actual big news event that is rapidly changing, or I feel the need for background noise and NPR is running a telethon. What I've found amazing is the ever increasing dumbing down of the network news. Whether it's the pretty blonde girl rapidly talking to compensate for depth, or guy who is either your best friend or far too avuncular chiming in with vague non-sequiturs, or the grizzled old guy with downcast eyes and a gruff demeanor, no one has anything intelligent to say. Maybe that is why all of the news organizations have gone to "experts" to give perspective on whatever it is that is being reported that moment.
I use to think that it was a time filling strategy, because there is rarely ever 24 hours worth of news (most days there is barely an hour). But alas, this isn't the case. The truth is that these people (and I use that term loosely) are just hired to look friendly and read whatever is put in front of them. Any conjecture, insightful questions, or witty banter is strictly frowned upon. Instead, these paid news readers are suppose to immediately turn to someone claiming to be an expert in whatever that field is for further analysis. If the news is in some way political (and what isn't?), they will call in two people who presumably are politically opposed. And in turn, these people repeat prepared statements and arguments from their own political side. The whole thing is choreographed so that no original thought is put forth and no one is asked a question that requires an answer that is more than a simple catchphrase or insult.
What the hapless viewer is left with is news that hasn't really told them anything. Something simple has been stated, both sides added their spin, and the person watching the show is forced into taking one of the sides as the truth. The whole thing is massively insulting to any rational human being. Moreover, because of the overall lack of real news throughout the day, soft news (Brittney Spears, Brangelina, or whatever dumb blond is that minute's "it girl") is reported upon just like the real news. The only difference is that the people on either side of the spin are paid to mock her and to do it with a smile. The 24 hour news stations need this infotainment to break up the constant propaganda being force fed from all sides.
In the end you are probably less informed then you were to start with. And I am left wondering why I turned it on in the first place.
Argh! I agree wholeheartedly with your argument. I can't stand the fact that you go to hear about the news and instead the majority of what you are presented with is fluff. I don't care about Brittany Spears and her latest comeback. If I wanted to hear about that, I'd go to E! or "People" not CNN or another major news organization. The fact that this fluff news is now the majority of the "headlines" presented by mainstream news organizations is despicable. I want to hear about the latest minority woman that was gunned down and the police are dragging their feet. I want to hear about the genocide in Sudan and its' impact on the African continent. I want to hear about the latest negotiations taking place in Iran over their nuclear materials. Heck, I'd even settle for an update on Sen. Ted Kennedy's cancer. At least that has some bearing on the country. Britney's latest botched wax job may be titilating, but it's most definitely not news. I think the majority of the problem stems from the fact that news organizations are being increasingly pushed away from their roots of reporting, and are now having to justify their monetary existence. The only way to do this is through increasing ratings share. The quickest and easiest way to do this is by converting into a news/entertainment format. It's not right, but unfortunately it's fact. This is why I no longer subscribe to any US news-magazine. The only one I'd even consider is the UK's "The Economist".