text:
Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer
Giorgia Zadra, Caroline F. Ribeiro, Paolo Chetta, Yeung Ho, Stefano Cacciatore, Xueliang Gao, Sudeepa Syamala, Clyde Bango, Cornelia Photopoulos, Ying Huang, Svitlana Tyekucheva, Debora C. Bastos, Jeremy Tchaicha, Brian Lawney, Takuma Uo, Laura D'Anello, Alfredo Csibi, Radha Kalekar, Benjamin Larimer, Leigh EllisLisa M. Butler, Colm Morrissey, Karen McGovern, Vito J. Palombella, Jeffery L. Kutok, Umar Mahmood, Silvano Bosari, Julian Adams, Stephane Peluso, Scott M Dehm, Stephen R. Plymate, Massimo Loda
Laboratory Medicine and Pathology
A hallmark of prostate cancer progression is dysregulation of lipid metabolism via overexpression of fatty acid synthase (FASN), a key enzyme in de novo fatty acid synthesis. Metastatic castration-resistant prostate cancer (mCRPC) develops resistance to inhibitors of androgen receptor (AR) signaling through a variety of mechanisms, including the emergence of the constitutively active AR variant V7 (AR-V7). Here, we developed an FASN inhibitor (IPI-9119) and demonstrated that selective FASN inhibition antagonizes CRPC growth through metabolic reprogramming and results in reduced protein expression and transcriptional activity of both full-length AR (AR-FL) and AR-V7. Activation of the reticulum endoplasmic stress response resulting in reduced protein synthesis was involved in IPI-9119–mediated inhibition of the AR pathway. In vivo, IPI-9119 reduced growth of AR-V7–driven CRPC xenografts and human mCRPC-derived organoids and enhanced the efficacy of enzalutamide in CRPC cells. In human mCRPC, both FASN and AR-FL were detected in 87% of metastases. AR-V7 was found in 39% of bone metastases and consistently coexpressed with FASN. In patients treated with enzalutamide and/or abiraterone FASN/ AR-V7 double-positive metastases were found in 77% of cases. These findings provide a compelling rationale for the use of FASN inhibitors in mCRPCs, including those overexpressing AR-V7.
ACKNOWLEDGMENTS. This work was supported by Department of Defense (DoD) IMPACT Grant PC160357 (to M.L., S.M.D., and S.R.P.), DoD synergistic Grant W81XWH1410405 (to M.L. and U.M.), NIH Grants R01-CA131945 and P50 CA90381, and the Prostate Cancer Foundation (PCF) (M.L.). G.Z. is a recipient of the DoD Idea Development Award for New Investigators (PC150263) and a Claudia Adams Barr Award in Innovative Cancer Research from the Dana-Farber Cancer Institute. The rapid autopsy material is the result of work supported by resources by the DoD (Award W81XWH-14-2-0183), the Pacific Northwest Prostate Cancer Specialized Programs of Research Excellence (SPORE) (Grant P50CA97186), and the Institute for Prostate Cancer Research. L. M.B. is supported by a Future Fellowship from the Australian Research Council (Fellowship FT130101004) and grant support from the Movember Foundation/ PCF of Australia.
This work was supported by Department of Defense (DoD) IMPACT Grant PC160357 (to M.L., S.M.D., and S.R.P.), DoD synergistic Grant W81XWH1410405 (to M.L. and U.M.), NIH Grants R01-CA131945 and P50 CA90381, and the Prostate Cancer Foundation (PCF) (M.L.). G.Z. is a recipient of the DoD Idea Development Award for New Investigators (PC150263) and a Claudia Adams Barr Award in Innovative Cancer Research from the Dana-Farber Cancer Institute. The rapid autopsy material is the result of work supported by resources by the DoD (Award W81XWH-14-2-0183), the Pacific Northwest Prostate Cancer Specialized Programs of Research Excellence (SPORE) (Grant P50CA97186), and the Institute for Prostate Cancer Research. L. M.B. is supported by a Future Fellowship from the Australian Research Council (Fellowship FT130101004) and grant support from the Movember Foundation/ PCF of Australia.
© 2019 National Academy of Sciences. All Rights Reserved.
AR-V7
Androgen signaling
Metastatic prostate cancer
Dive into the research topics of 'Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer'. Together they form a unique fingerprint.
Lipogenesis Medicine & Life Sciences 100%
Castration Medicine & Life Sciences 89%
Androgen Receptors Medicine & Life Sciences 87%
Fatty Acid Synthases Medicine & Life Sciences 67%
MDV 3100 Medicine & Life Sciences 21%
Neoplasm Metastasis Medicine & Life Sciences 13%
abiraterone Medicine & Life Sciences 11%
Zadra, G., Ribeiro, C. F., Chetta, P., Ho, Y., Cacciatore, S., Gao, X., Syamala, S., Bango, C., Photopoulos, C., Huang, Y., Tyekucheva, S., Bastos, D. C., Tchaicha, J., Lawney, B., Uo, T., D'Anello, L., Csibi, A., Kalekar, R., Larimer, B., ... Loda, M. (2019). Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer. Proceedings of the National Academy of Sciences of the United States of America, 116(2), 631-640. https://doi.org/10.1073/pnas.1808834116
Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer. / Zadra, Giorgia; Ribeiro, Caroline F.; Chetta, Paolo et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 116, No. 2, 08.01.2019, p. 631-640.
Zadra, G, Ribeiro, CF, Chetta, P, Ho, Y, Cacciatore, S, Gao, X, Syamala, S, Bango, C, Photopoulos, C, Huang, Y, Tyekucheva, S, Bastos, DC, Tchaicha, J, Lawney, B, Uo, T, D'Anello, L, Csibi, A, Kalekar, R, Larimer, B, Ellis, L, Butler, LM, Morrissey, C, McGovern, K, Palombella, VJ, Kutok, JL, Mahmood, U, Bosari, S, Adams, J, Peluso, S, Dehm, SM, Plymate, SR & Loda, M 2019, 'Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 2, pp. 631-640. https://doi.org/10.1073/pnas.1808834116
Zadra G, Ribeiro CF, Chetta P, Ho Y, Cacciatore S, Gao X et al. Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer. Proceedings of the National Academy of Sciences of the United States of America. 2019 Jan 8;116(2):631-640. doi: 10.1073/pnas.1808834116
Zadra, Giorgia ; Ribeiro, Caroline F. ; Chetta, Paolo et al. / Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer. In: Proceedings of the National Academy of Sciences of the United States of America. 2019 ; Vol. 116, No. 2. pp. 631-640.
@article{13f4e6d247e7438e9f7fc655c0ffd0d7,
title = "Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer",
abstract = "A hallmark of prostate cancer progression is dysregulation of lipid metabolism via overexpression of fatty acid synthase (FASN), a key enzyme in de novo fatty acid synthesis. Metastatic castration-resistant prostate cancer (mCRPC) develops resistance to inhibitors of androgen receptor (AR) signaling through a variety of mechanisms, including the emergence of the constitutively active AR variant V7 (AR-V7). Here, we developed an FASN inhibitor (IPI-9119) and demonstrated that selective FASN inhibition antagonizes CRPC growth through metabolic reprogramming and results in reduced protein expression and transcriptional activity of both full-length AR (AR-FL) and AR-V7. Activation of the reticulum endoplasmic stress response resulting in reduced protein synthesis was involved in IPI-9119–mediated inhibition of the AR pathway. In vivo, IPI-9119 reduced growth of AR-V7–driven CRPC xenografts and human mCRPC-derived organoids and enhanced the efficacy of enzalutamide in CRPC cells. In human mCRPC, both FASN and AR-FL were detected in 87% of metastases. AR-V7 was found in 39% of bone metastases and consistently coexpressed with FASN. In patients treated with enzalutamide and/or abiraterone FASN/ AR-V7 double-positive metastases were found in 77% of cases. These findings provide a compelling rationale for the use of FASN inhibitors in mCRPCs, including those overexpressing AR-V7.",
keywords = "AR-V7, Androgen signaling, Fatty acid synthase, Metabolomics, Metastatic prostate cancer",
author = "Giorgia Zadra and Ribeiro, {Caroline F.} and Paolo Chetta and Yeung Ho and Stefano Cacciatore and Xueliang Gao and Sudeepa Syamala and Clyde Bango and Cornelia Photopoulos and Ying Huang and Svitlana Tyekucheva and Bastos, {Debora C.} and Jeremy Tchaicha and Brian Lawney and Takuma Uo and Laura D{\textquoteright}Anello and Alfredo Csibi and Radha Kalekar and Benjamin Larimer and Leigh Ellis and Butler, {Lisa M.} and Colm Morrissey and Karen McGovern and Palombella, {Vito J.} and Kutok, {Jeffery L.} and Umar Mahmood and Silvano Bosari and Julian Adams and Stephane Peluso and Dehm, {Scott M} and Plymate, {Stephen R.} and Massimo Loda",
note = "Funding Information: ACKNOWLEDGMENTS. This work was supported by Department of Defense (DoD) IMPACT Grant PC160357 (to M.L., S.M.D., and S.R.P.), DoD synergistic Grant W81XWH1410405 (to M.L. and U.M.), NIH Grants R01-CA131945 and P50 CA90381, and the Prostate Cancer Foundation (PCF) (M.L.). G.Z. is a recipient of the DoD Idea Development Award for New Investigators (PC150263) and a Claudia Adams Barr Award in Innovative Cancer Research from the Dana-Farber Cancer Institute. The rapid autopsy material is the result of work supported by resources by the DoD (Award W81XWH-14-2-0183), the Pacific Northwest Prostate Cancer Specialized Programs of Research Excellence (SPORE) (Grant P50CA97186), and the Institute for Prostate Cancer Research. L. M.B. is supported by a Future Fellowship from the Australian Research Council (Fellowship FT130101004) and grant support from the Movember Foundation/ PCF of Australia. Funding Information: This work was supported by Department of Defense (DoD) IMPACT Grant PC160357 (to M.L., S.M.D., and S.R.P.), DoD synergistic Grant W81XWH1410405 (to M.L. and U.M.), NIH Grants R01-CA131945 and P50 CA90381, and the Prostate Cancer Foundation (PCF) (M.L.). G.Z. is a recipient of the DoD Idea Development Award for New Investigators (PC150263) and a Claudia Adams Barr Award in Innovative Cancer Research from the Dana-Farber Cancer Institute. The rapid autopsy material is the result of work supported by resources by the DoD (Award W81XWH-14-2-0183), the Pacific Northwest Prostate Cancer Specialized Programs of Research Excellence (SPORE) (Grant P50CA97186), and the Institute for Prostate Cancer Research. L. M.B. is supported by a Future Fellowship from the Australian Research Council (Fellowship FT130101004) and grant support from the Movember Foundation/ PCF of Australia. Publisher Copyright: {\textcopyright} 2019 National Academy of Sciences. All Rights Reserved.",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
T1 - Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer
AU - Zadra, Giorgia
AU - Ribeiro, Caroline F.
AU - Chetta, Paolo
AU - Ho, Yeung
AU - Cacciatore, Stefano
AU - Gao, Xueliang
AU - Syamala, Sudeepa
AU - Bango, Clyde
AU - Photopoulos, Cornelia
AU - Tyekucheva, Svitlana
AU - Bastos, Debora C.
AU - Tchaicha, Jeremy
AU - Lawney, Brian
AU - Uo, Takuma
AU - D'Anello, Laura
AU - Csibi, Alfredo
AU - Kalekar, Radha
AU - Larimer, Benjamin
AU - Ellis, Leigh
AU - Butler, Lisa M.
AU - Morrissey, Colm
AU - McGovern, Karen
AU - Palombella, Vito J.
AU - Kutok, Jeffery L.
AU - Mahmood, Umar
AU - Bosari, Silvano
AU - Adams, Julian
AU - Peluso, Stephane
AU - Dehm, Scott M
AU - Plymate, Stephen R.
AU - Loda, Massimo
N1 - Funding Information: ACKNOWLEDGMENTS. This work was supported by Department of Defense (DoD) IMPACT Grant PC160357 (to M.L., S.M.D., and S.R.P.), DoD synergistic Grant W81XWH1410405 (to M.L. and U.M.), NIH Grants R01-CA131945 and P50 CA90381, and the Prostate Cancer Foundation (PCF) (M.L.). G.Z. is a recipient of the DoD Idea Development Award for New Investigators (PC150263) and a Claudia Adams Barr Award in Innovative Cancer Research from the Dana-Farber Cancer Institute. The rapid autopsy material is the result of work supported by resources by the DoD (Award W81XWH-14-2-0183), the Pacific Northwest Prostate Cancer Specialized Programs of Research Excellence (SPORE) (Grant P50CA97186), and the Institute for Prostate Cancer Research. L. M.B. is supported by a Future Fellowship from the Australian Research Council (Fellowship FT130101004) and grant support from the Movember Foundation/ PCF of Australia. Funding Information: This work was supported by Department of Defense (DoD) IMPACT Grant PC160357 (to M.L., S.M.D., and S.R.P.), DoD synergistic Grant W81XWH1410405 (to M.L. and U.M.), NIH Grants R01-CA131945 and P50 CA90381, and the Prostate Cancer Foundation (PCF) (M.L.). G.Z. is a recipient of the DoD Idea Development Award for New Investigators (PC150263) and a Claudia Adams Barr Award in Innovative Cancer Research from the Dana-Farber Cancer Institute. The rapid autopsy material is the result of work supported by resources by the DoD (Award W81XWH-14-2-0183), the Pacific Northwest Prostate Cancer Specialized Programs of Research Excellence (SPORE) (Grant P50CA97186), and the Institute for Prostate Cancer Research. L. M.B. is supported by a Future Fellowship from the Australian Research Council (Fellowship FT130101004) and grant support from the Movember Foundation/ PCF of Australia. Publisher Copyright: © 2019 National Academy of Sciences. All Rights Reserved.
N2 - A hallmark of prostate cancer progression is dysregulation of lipid metabolism via overexpression of fatty acid synthase (FASN), a key enzyme in de novo fatty acid synthesis. Metastatic castration-resistant prostate cancer (mCRPC) develops resistance to inhibitors of androgen receptor (AR) signaling through a variety of mechanisms, including the emergence of the constitutively active AR variant V7 (AR-V7). Here, we developed an FASN inhibitor (IPI-9119) and demonstrated that selective FASN inhibition antagonizes CRPC growth through metabolic reprogramming and results in reduced protein expression and transcriptional activity of both full-length AR (AR-FL) and AR-V7. Activation of the reticulum endoplasmic stress response resulting in reduced protein synthesis was involved in IPI-9119–mediated inhibition of the AR pathway. In vivo, IPI-9119 reduced growth of AR-V7–driven CRPC xenografts and human mCRPC-derived organoids and enhanced the efficacy of enzalutamide in CRPC cells. In human mCRPC, both FASN and AR-FL were detected in 87% of metastases. AR-V7 was found in 39% of bone metastases and consistently coexpressed with FASN. In patients treated with enzalutamide and/or abiraterone FASN/ AR-V7 double-positive metastases were found in 77% of cases. These findings provide a compelling rationale for the use of FASN inhibitors in mCRPCs, including those overexpressing AR-V7.
AB - A hallmark of prostate cancer progression is dysregulation of lipid metabolism via overexpression of fatty acid synthase (FASN), a key enzyme in de novo fatty acid synthesis. Metastatic castration-resistant prostate cancer (mCRPC) develops resistance to inhibitors of androgen receptor (AR) signaling through a variety of mechanisms, including the emergence of the constitutively active AR variant V7 (AR-V7). Here, we developed an FASN inhibitor (IPI-9119) and demonstrated that selective FASN inhibition antagonizes CRPC growth through metabolic reprogramming and results in reduced protein expression and transcriptional activity of both full-length AR (AR-FL) and AR-V7. Activation of the reticulum endoplasmic stress response resulting in reduced protein synthesis was involved in IPI-9119–mediated inhibition of the AR pathway. In vivo, IPI-9119 reduced growth of AR-V7–driven CRPC xenografts and human mCRPC-derived organoids and enhanced the efficacy of enzalutamide in CRPC cells. In human mCRPC, both FASN and AR-FL were detected in 87% of metastases. AR-V7 was found in 39% of bone metastases and consistently coexpressed with FASN. In patients treated with enzalutamide and/or abiraterone FASN/ AR-V7 double-positive metastases were found in 77% of cases. These findings provide a compelling rationale for the use of FASN inhibitors in mCRPCs, including those overexpressing AR-V7.
KW - AR-V7
KW - Androgen signaling
KW - Fatty acid synthase
KW - Metabolomics
KW - Metastatic prostate cancer
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America


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Each season I pick a destination as a point of inspiration, and that's where the color pallet comes from.
Jaclyn began conceiving of doing a line in the summer of 2011 when she went to New Mexico for Ram Das Puri, a summer solstice meditation gathering of Kundalini practitioners. It was there that she gained a clarity about changes she wanted to make in her life. By fall 2011 she had started working on the patterns for her line, and ultimately launched the line in September 2012.
The changes in the collection from season to season are subtle, "It isn't reinventing the wheel in terms of creating new silhouettes." The slip dress designs are consistently based on '30s and '70s silhouettes. The key to what makes each collection unique is the part of the world it's based on. "Each season I pick a destination as a point of inspiration, and that's where the color pallet comes from. And there's also a subtle design directive that comes from there. In the Thai collection (Spring/Summer '14), for example, there were some shirts that were traditional Thai style." In addition to Thai, she has collections inspired by Sedona in Arizona, a Malibu-in-the-'70s collection, and a collection inspired by a mixture of Rishikesh and Varanasi (where Jaclyn recently waded in the Ganges).
The name Awaveawake has both visual and auditory connotations. "It's like a poem. A conglomeration of three words 'A,' 'Wave,' 'Awake.' At first I was being a little more obvious with names like 'Aquarian Designs' (because in Kundalini Yoga there's so much emphasis on the Aquarian Age). But that was a bit basic. I kept on seeing patterns through doing meditation and the Ws in Awaveawake matched those patterns; it jumped out at me." Perhaps most importantly, the name also refers to the waves of awakening, opening up, and awareness that she sees more and more in the people in her life.
Every time I see Jaclyn or a picture of her she seems to sporting a maxi skirt. I asked her if this is a coincidence. She explained that through her travels in the East, she's become familiar with eastern women's sense of propriety in covering their legs, which complimented the natural feeling of safety she gets from wearing long things. The long skirts she wears also provide a balance between a garment that covers the body and a garment that's cut close to the body and flatters its form. The Awaveawake silhouette finds the equilibrium between hiding and revealing the body.
All Awaveawake garments are naturally dyed in California. And when Jaclyn says natural, she doesn't mean natural like your soda "includes natural and artificial flavors." She means fully natural. Like her blue is actual indigo and her red is made of bugs. Jaclyn came to this decision after learning the scale of the environmental damage from the waste produced by synthetic dyeing facilities, making synthetic dying the most harmful aspect of garment industry, which is the 3rd largest industry in the world."I hesitate to say it's an eco-sustainable collection, even though it is, because I think that's just the way things should just be going. They're not really working any more, the old ways." And so Awaveawake helps move away from these ways in preparation, perhaps, for the Aquarian Age.


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Auschwitz-Birkenau Barracks Defaced With Anti-Semitic Graffiti
(RepublicanNews.org) – Auschwitz was a concentration camp during the Second World War where atrocities against humans took place. Now, the site stands as a memorial and a reminder of how hate and intolerance directly affected the lives of Jews and other people. Decades after the war's end, hatred marred Auschwitz again.
In a place dedicated to peace and healing, someone defaced nine barracks at the Auschwitz-Birkenau Memorial site with antisemitic graffiti. Both police and the memorial staff are asking anyone with knowledge of the heinous crime to come forward. Authorities said the inscriptions were spray-painted in both German and English.
Wooden barracks at the Auschwitz-Birkenau Memorial and Museum were vandalized Tuesday with anti-Semitic inscriptions, the memorial said https://t.co/FNw0WDGS04
— The Wall Street Journal (@WSJ) October 6, 2021
The museum staff reported the case to the police and plan to remove all traces of the graffiti once the authorities complete the investigation. Auschwitz was the largest Nazi concentration camp. The Waffen-SS sent approximately 1.3 million people to the location between 1940 and 1945; 1.1 million, including 960,000 Jews, died in the camp in those five years.
The site remains a museum, a reminder of the ugliness humans are capable of inflicting on each other, and a caution to the future never to forget. Dani Dayan, the chairman of Israel's official memorial for Holocaust victims, Yad Vashem, said the act of vandalism wasn't just an attack on the memory of those who died but also on survivors, as well.
Yet even this act of disrespect and intolerance serves to remind us why it's so important not to forget the lessons of Auschwitz. The irony is the perpetrators who disrespected the museum only strengthened its message: Never forget.


A Leitches Creek car rental allows you to go where you want, when you want. You can check out all the sights, and even find out what else the rest of Nova Scotia has to offer. CarRentals.com has gathered the most frequently asked questions about car rentals in Leitches Creek. Keep reading to discover how to get the best rates on your ideal vehicle.
Where can I get a bargain rental car in Leitches Creek?
These tips can help you save even more on your next car rental in Leitches Creek.
What rental companies have outlets in Leitches Creek?
From global names like Avis and Sixt to budget-friendly brands like Fox and Budget, CarRentals.com has some of the best brands in the business. Scan through the reviews to help you figure out which is best for you.
What type of rental car should I get for my trip to Leitches Creek?
What age do you have to be to rent a car in Leitches Creek?
Typically, to rent a car in Leitches Creek you must be at least 21—the same as it is across the rest of the country. Additionally, many suppliers charge an added fee if you are under 25. Be sure to go over the supplier's terms to find what the total will be before you book your car.
Is insurance required to rent a car in Leitches Creek?
Almost all countries require the driver to have insurance. You may be able to buy temporary coverage with the rental car supplier.Many credit cards (Discover, American Express, Visa, and MasterCard) will cover your car rental. But many of them have restrictions, such as not covering larger vehicles such as trucks or SUVs. It is best to call and find out what kind of coverage is offered before you head to Leitches Creek.
Most rental car companies provide you a full tank policy. At CarRentals.com, we encourage returning it filled up. If you want to keep your expenses lower, fill up your tank before you bring it back. Stations close to airports or car rental places tend to have higher prices.
Should I get unlimited miles when I rent a car in Leitches Creek?
Unlimited miles is a great choice if you decide to do a bit of sightseeing or visit a lot of business associates all over Leitches Creek. You can drive as much as you want and not incur extra charges. Make sure to read your policy to discover if there are mileage limitations.
Use CarRentals.com to get yourself the best wheels Leitches Creek has to offer. Before you know it, you'll be going between the great restaurants, famous landmarks, and all the fantastic sites in Leitches Creek.


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ACV to pour VND4 trillion into upgrading Cat Bi International Airport
Tuesday, Nov 27, 2018 16:19
Cat Bi International Airport is already overloaded, so efforts to expand and upgrade its facilities are necessary. — VNA/VNS Photo
The Airports Corporation of Viet Nam (ACV) is focusing on accelerating investment in key projects at Cat Bi International Airport (Hai Phong) with a total investment capital of about VND4 trillion (US$170.1 million).
These projects include passenger terminal T2, a parking lot in front of the new terminal and a cargo terminal, as well as a number of projects to renovate and expand existing aircraft parking areas.
For the T2 construction project, ACV has completed the selection of consultancy contractors for the feasibility study (FS). The winning contractors are preparing architectural plans for the passenger terminal, the FS and basic designs.
The terminal will have a capacity of five million passengers per year and be able to expand to 10 million passengers per year. The auxiliary works for the terminal include the synchronous infrastructure system and traffic system to connect with terminal T1. Total investment is around VND1.6 trillion (excluding land clearance costs) and construction is scheduled to complete by the fourth quarter of 2020.
ACV is completing the procedures for the approval of expansion projects as regulated. The project of building a cargo terminal and parking lot in front of T2 is in the process of selecting consultant contractors to carry out a feasibility study.
According to a representative of ACV, the number of passengers, journeys and cargo through Cat Bi International Airport has exceeded the capacity of its design. Besides, traffic connections between Hai Phong and neighbouring localities will increase demands in travelling by air in the coming time. Therefore, upgrades and expansions of the airport's infrastructure are urgently needed.
The project to build a parking area in front of the cargo terminal has a total investment of about VND850 billion. The commodity station has a capacity of 100,000 tonnes of cargo per year and it is planned to expand to 250,000 tonnes of cargo per year. The auxiliary works for the terminal and the infrastructure system have a total investment of about VND390 billion.
Hai Phong confirmed the city will focus on leadership, direction and co-ordinating with ACV to ensure progress.
At the same time, the port city asked ACV to propose more areas that can be cleared to meet the development needs of Cat Bi International Airport in the future. The city also requested ACV focus resources, select good investors and strive to complete the project in 2020. — VNS
Tags Airports Corporation of Viet Nam ACV Cat Bi International Airport Hai Phong province
Northstar Group pours $50 million into VN online education company
New vision needed for future of Asia: Deputy PM
Aviation earnings to get a boost from low oil prices
Vina TT builds fresh coconut plant
VN wins steel dispute with Indonesia
VN improves on sustainable trade
Demand for food spikes in city
Energy sector faces big challenges ahead
Quang Ninh considers fee reduction for tourists arriving by air
Hung Yen revokes licenses from 14 delayed projects
$15m plant opens in Ha Nam


It is important for you to be able to register yourself with an insurance policy in order to have a contingency plan where all emergencies are catered for when you don't have emergency money to take care of all the debts that you have, the insurance policies are important in that particular area.
The major advantages of insurance premiums is where the policies are offered on different products the insurance company offers, there is one of the insurance covers that is popularly known and the cover involved the term life insurance where one is able to be get some of the insurance policy after a period of time.
At times when it comes to Buying Term Life, it is advisable not to buy all of it, instead, you should ensure that the amount that has already remained is enough in order to help you create a short investment elsewhere so that you can be able to gain from the policy.
It is important to make sure that you are aware of what you need with the insurance, this means that you will have to make sure that you get the premium that is required according to your needs, this includes the getting the coverage of what you want to be covered.
In most insurance policies there is a law in the insurance firms that brings about the knowledge of the more you want to be covered, there more the premium becomes, this is to help balance the equation in a whole sum.
In most insurance firms life insurance is considered to be the utmost important policies because anything related to the right of life it is very vital, this means when more people die the business tends to die, therefore it is important to make sure you protect this life with a lot of fortitude.
Insurance firms benefit a lot when many people are subscribing for different types of insurance policies, this means that you are able to pay up some of the fees may be annually or according to the agreement signed when subscribing to the insurance.
The best term life insurance corporations provide an opportunity for you to evaluate the insurance rates and also allow you to select the right insurance in order to achieve your goals.


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The Hidden Risks of Access Management
By Patricia Diaz
Today more than ever, enterprise access control has been stretched thin as more third-party apps, suppliers and new technologies enter the corporate network.
What Aggravates Access Risk?
Complexity comes as a result of new functionalities and networks entering the corporate environment. Beyond managing growing active directories, corporate access management has become more complex due to systems that have their own access management controls — think new mobile, social and cloud applications. Crawford asked, "How many access control systems does your organization have — really?" Answering this question is essential to surveying your environment and identifying relevant risks.
In effect, access management complexity becomes more than just managing users in the system. It's also about finding ways to stay in control of the enterprise and its new third-party apps and functionalities.
That said, with complexity being an increasingly relevant risk factor, so is the complacency with which organizations manage access. In most environments, Crawford explained, complacency boils down to two main factors: too much and too long. There's too much unrestricted high-privilege access with out-of-date policies. Risks that are far too real remain for too long, and cybercriminals learn to exploit them.
Hidden Risks: Complexity and Complacency?
The first step in tackling hidden risks is centralizing access management.
"We see many people having deployed many access management solutions for [mobile and cloud] technologies," Brandon Whichard of IBM Product Marketing explained during the second half of the webinar. "If you have five different access management solutions, you don't have any access management because it is so complicated to manage."
Once access is centralized in one appliance, the enterprise can start truly taking control of its access management and governance. As such, Whichard introduced IBM's three-question framework for taking control of identity and access management. Organizations should ask themselves:
Is this really a valid user?
What does the user want to do?
What access does that user need to do his or her job?
In response, the enterprise can take the following corresponding actions:
Look at parameters that enable risk-based access control.
Flag and record business behavior with a trust-but-verify approach.
Ensure IT understands what business users need to do their jobs to make auditing a smoother and more accurate process.
Moving Forward With Access Management
Centralizing access management is the first step to truly getting a grip on access management and taking back control of enterprise access and risk. When selecting the appliance best for your organization, I encourage you to revisit Whichard's framework to ensure your solution can help you answer all three essential questions.
Download this white paper to learn how to Take back control of access management
Access Management | Identity and Access Management (IAM) | Risk Management
Patricia Diaz
Portfolio Marketing Manager, IBM
Patricia Diaz is a worldwide Portfolio Marketing Manager for IBM Security. Since joining IBM in 2014, Patricia has held roles in sales and product marketing ...


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Order of Battle: Pacific
American Civil War: The Blue and the Gray
Scythe: Digital Edition
Baldur's Gate: Dark Alliance II
Secret of Mana (2018)
Phantom Brave
Medal of Honor: Airborne
Tom Clancy's Ghost Recon: Advanced Warfighter 2
Zork I: The Great Underground Empire
Star Wars: Battlefront II (2005)
P.T.O. IV: Pacific Theater of Operations
Gauntlet (1985)
Brain Challenge
Strat-O-Matic Baseball
Reiner Knizia's Labyrinth
Disney-Pixar's Cars 2: The Video Game
The Magic Candle
The Adventures of Tintin: The Secret of the Unicorn – The Game
Warlock: Master of the Arcane
MotoGP (N-Gage)
N-Gage Rank: N/A
Sports - Motorcycling
Network Multiplayer
North American N-Gage edition
Publisher: Nokia
Developer: THQ
Media: Disk Cards
Rating: ESRB: E
User Summary
MotoGP for the N-Gage is a simplified title in the MotoGP series. The game is based on the Xbox release.
Like other titles in the series, players can choose from a number of licensed riders from the MotoGP championship. The game starts with two playable tracks, but five more can be unlocked during play. The control scheme is slimmed down for the portable title. Players use one button to accelerate and one to brake, and the control pad to steer. There are no enhanced control maneuvers, such as manual shifting, available.
The N-Gage title features four game modes, including a multiplayer that allows up to four players to race against one another.


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Soundtrack Review | "Logan"
James Mangold's Logan is not your typical superhero movie. While my review of the film itself will appear in Thursday's print edition of The Dispatch, I wanted to highlight one of the film's strongest elements on its own - Marco Beltrami's unconventional score.
The character of Wolverine has never had a strong thematic identity to carry him through the eight X-Men films in which he has appeared, and while Beltrami also scored Mangold's The Wolverine in 2013, he starts with a clean slate here. Right away it is clear that this will not be a typical superhero score. Beltrami starts things off with a simple piano motif in Main Titles, it's minor chord progressions reflecting Logan's loneliness. The introduction of a wailing harmonica at around the 1:30 mark announces the film's western influences, recalling the spaghetti western scores of Ennio Morricone.
Much of the score dwells in the background. Laura has an eerie kind of ambiance to it (recalling the quieter moments of Beltrami's western score, The Homesman), while The Grim Reavers and Old Man Logan have a more dissonant sound. Old Man Logan brings back Logan's piano theme from the main titles, establishing the melody as the grizzled Wolverine's primary musical identity. Alternate Route to Mexico really kicks the score into high gear, with a suspenseful string line that accompanies Logan's attempts to evade detection by mysterious agents who are looking for mutants.
Beltrami does fall back into some generic sounding action material, as heard in bass-heavy tracks like That's Not a Choo-Choo, X-24, and Farm Aid that rely on synths and pulsing rhythms, not unlike Beltrami's work on Mangold's 3:10 to Yuma. Things get interesting, however, in El Limo-nator, which introduces a honky-tonk piano into the action, reinforcing the score's western flair . The thematic material for Laura, Logan's young charge, begins to take greater shape in Gabriella's Video, as Logan discover's Laura's true identity. Minimalism is the name of the game here, with its use of ambient synths and wind-chimes, but the effect is lovely. It reappears in Goodnight Moon, grounding the score in a kind of quiet humanity.
It's interesting that Beltrami chose to anchor the score with a piano, especially as Logan's main identity. There's something familiar about the piano that speaks of home and family, and Beltrami uses that to his advantage here, giving us a haunting melodic texture (rather than a hummable theme) to represent the grizzled old hero. The piano motif reappears in You Can't Break the Mould and Up to Eden, before bringing the score to a heartrendingly restrained finale in Don't Be What They Made You. Without a recognizable thematic identity from the past, Beltrami chooses instead to bid farewell to Wolverine with a quiet and aching piano solo, before rounding out the score with a full presentation of Laura's theme in Eternum, with its western piano and harmonica accents. The album is closed out by three meandering bonus tracks that are intriguing from an orchestration standpoint, but ultimately add little to the album.
Superhero scores tend to be defined by their action music. And while there are some strong action tracks here - Forest Fight is the closest the score gets to grand-scale action scoring, before slipping back into the atonal suspense of Logan vs. X-24, the quiet moments are what really define Logan. Don't come to this score expecting larger than life heroics. Like the film itself, it is a dark and introspective score. But it's also one of the most unconventional and effective superhero scores to come along in a long time. It may not always be an easy listen, but Beltrami wisely chose to give the character a harsh and gritty musical identity, whose rough exterior belies a tender heart. It never overstates its purpose, but the effect resonates long after the credits roll.
GRADE - ★★★ (out of four)
Now available for digital download. On CD March 31.
Blu-Ray Review | "Being There"
From the Repertory | 3/30/17
Review | "Power Rangers"


Doing a volte-face on its power-sector reform agenda, the Uttar Pradesh government has dropped a plan to implement the franchise model for privatisation of electricity distribution in the state's five cities, including capital Lucknow, and withdrew the tender documents inviting bids under the integrated service provider scheme (ISPS) for seven districts. Under ISPS, the idea was to hand over the work of electricity billing, meter installation and reading, revenue collection, etc, to private service providers to improve efficiency and reduce pilferage. The state government's move, announced late on Thursday, came after a 20-day boycott of work by the employees of the state power department UPPCL in protest against the moves.The employees have called off the strike. The decision to put the reform plans in abeyance could cost the state's power sector dear. The aggregate technical and commercial (AT&C) losses of the state's five electricity distribution companies (discoms) stood at 30.9% at the end of December 2017, only marginally down from 32.4% when the state joined the central government's Ujwal Discom Assurance Yojana (UDAY) scheme for the revival of the country's debt-laden discoms.
As per the AT&C loss reduction trajectory charted by UDAY, UP's FY18 losses should have been lower at 23.6%. According to analysts, the UP discoms' AT&C losses are expected to rise further as more households are getting electrified under the Saubhagya (100% household electrification) scheme. The state discoms posted losses of Rs 21,486 crore in FY16. Their FY17 losses, on an unaudited basis, came down to Rs 6,619 crore and according to the UDAY portal, the losses in FY18 were at Rs 3,634 crore till December 2017. According to an agreement signed between the state's principal secretary (energy) Alok Kumar and the employees' representatives, UPCCL would not implement any privatisation without taking the workers into confidence. While the privatisation of power distribution was envisaged in the Electricity Act, 2003, progress has been slow so far. Apart from the national capital region, a few cities including Mumbai, Kolkata and Ajmer have private licensees running the distribution business while the franchise model is prevalent in most of Odisha and in a clutch of towns in other states like Asansol, Ajmer, Kota, Bikaner and Bhiwandi.
As per the Uttar Pradesh government's plan, the franchise model was to be introduced in Lucknow, Varanasi, Gorakhpur, Meerut and Moradabad and integrated service providers were to be appointed in the seven districts of Raebareli, Kannauj, Etawah, Orai, Mau, Ballia and Saharanpur. The state cabinet had approved these plans earlier. "The decision to privatise power distribution was arbitrary and therefore needed to be taken back. Engineers have been giving their best to improve power situation and curtail revenue losses," said Shailendra Dubey, convener of UP Vidyut Karmachari Sangharsh Samiti.


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Price search engine marketing isn't a brand-new concept coach anyone how to used in the retail and travel market sectors for a long time. That determines the cost elasticity for the specific consumer in a particular transaction. It truly is nothing more than the process of determining the proper retail worth of a client product or service. Since it does not make use of actuarially sensible methods to estimate the risk of loss, its utilization in the ratemaking process is certainly unfairly discriminatory and violates California rules. Personalized price tag optimization is now essential to a great organization's belief for a great outcome. The corporation makes their cash by including a percentage to bookings. You should also try a business that's notorious intended for treating their customers well. To begin with, most companies should begin by creating and educating a bit pricing workforce. Many businesses include embraced cost optimization equipment to help determine what price they may charge for their merchandise or perhaps solutions. Consequently the company may well price the item within that budget. Costs optimization software applications companies just like Revionics, dunnhumby, and PROS let price tag grocers leverage predictive analytics to generate price changes in actual time that the sector is beginning get in. Fees is already quite complex, and inconsistency can just boost complexity and cause pandemonium. With the right technology in place, it includes the potential to become powerful revenue lever. Cost-plus pricing is undoubtedly far simpler to calculate and thus common, but it really isn't the suitable strategy for capitalizing on revenue. Value-based pricing is essential to maximize revenue because it targets on the customer. Optimal pricing is important if a business wishes to link it is enterprise volume with profits and furthermore, if this wants to enhance profits by keeping exactly the same altitudes of consumer retention. By precisely the same time, pertaining to little and vulnerable businesses competitive fees might be a deadly practice by itself because retailpriceoptimization.com literally possess zero border for problem. Whenever you modification prices, mountain range of data were created and it comprises silver insights. Additionally , it results in that their prices subject a good deal. For the item is usually priced too high, perhaps keep in mind that sell what ever, while in the function the price can be reduced too much, the company definitely going to make a profit. If you choose a price that wins a lot of sales to your goods, observe your competitors' prices at this time. With vibrant pricing, you'll certainly be in a position to immediately better your prices in the phase from the product. Searching out the most suitable cost was once regarding just finding out how to value your goods or support. Selling price isn't placed by the current market or simply by customers. When it becomes the principal concern for the customers, it is extremely radical for the organizations to mark the start of the trip. Your 1st price is a tremendous one, as it will act as an anchor from where shoppers should compare the rest of the prices you post. Just for image goods that you may not need to worry very much about suprisingly low rates, you can actually solely include margin.


The Humane Society Chatham-Savannah Applications are available at The Humane Society, 7215 Sallie Mood Drive. For a complete list of available pets, go to www.HumaneSocietySAV.org. To learn about these pets or foster and volunteer programs, call 912-354-9515 or e-mail dnasser@humanesocietysav.org.
Adoptions are 11 a.m.-3 p.m. Saturdays PetSmart on Abercorn Street. Adoption fee covers the cost of spay/neuter, vaccination and health check. Call 912-598-7729 or go to www.savealifepets.org.
100 Dichroic Dragon Drive, Pembroke, GA 31321. View other animals at the shelter at www.gardonline.org/. For appointments, call Joy Bohannon at 912-653-2480. GARD has adoptions from 2-7 p.m. every day at the GARD shelter.
A nonprofit, charitable organization focused on education, cruelty prevention and rescue of the Great Dane breed. Call Pam and Jimmy Hunt: 912-856-0830 or 912-856-0831.


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New Trailer for the New Live Action Film CINDERELLA
February 11, 2015 by Thrifty 4nsic Gal Leave a Comment
#Cinderella
We all know the story of Cinderella and the cruel step-mother and cruel step sisters. Now comes a new making of Cinderella in theaters March 13, 2015. I can not wait to see this re-make. Cinderella was one of my many favorites growing up.
Cinderella – Official US Trailer #2
Watch this Trailer HERE or you can see it below.
You can be sure to keep up with all new trailers and fun of CINDERELLA On their Website: HERE
Facebook: HERE
Twitter: HERE
Instagram: HERE
Pinterest: HERE
Google +: HERE
CINDERELLA opens in theaters everywhere on March 13th! Do not miss it, because I sure wont be!
WALT DISNEY STUDIOS MOTION PICTURES
Genre: Live Action
U.S. Release date: March 13, 2015
Cast: Cate Blanchett, Lily James, Richard Madden, Stellan Skarsgård,
Holliday Grainger, Sophie McShera, Derek Jacobi and Helena Bonham Carter
Producers: Simon Kinberg, Allison Shearmur, David Barron
Executive Producer: Tim Lewis
Screenplay by: Chris Weitz
The story of "Cinderella" follows the fortunes of young Ella (Lily James) whose merchant father remarries following the death of her mother. Eager to support her loving father, Ella welcomes her new Stepmother (Cate Blanchett) and her daughters Anastasia (Holliday Grainger) and Drisella (Sophie McShera) into the family home. But, when Ella's father unexpectedly passes away, she finds herself at the mercy of a jealous and cruel new family.
Soon, she is forced to become their servant, disrespected, covered in ashes and spitefully renamed Cinderella. Yet, despite the cruelty inflicted upon her, Ella will not give in to despair nor despise those who mistreat her, and she continues to remain positive, determined to honor her mother's dying words and to "have courage and be kind."
When Ella meets a dashing stranger in the woods, unaware that he is really the Prince (Richard Madden) and not merely Kit, an apprentice at the palace, she believes she has finally found a kindred soul. It appears her fortunes may be about to change when the King (Derek Jacobi) summons all maidens in the kingdom to attend a royal ball at the palace, raising Ella's hopes of once again encountering the charming Kit. Alas, her Stepmother forbids her to attend and callously destroys her dress.
Meanwhile, the calculating Grand Duke (Stellan Skarsgård) devises a plan to thwart the Prince's hopes of reuniting with Ella and enlists the support of the devious Stepmother. But, as in all good fairy tales, help is at hand. Soon, a kindly beggar woman (Helena Bonham Carter) steps forward and, armed with a pumpkin, a few mice and a magic wand, changes Cinderella's life forever.
ONE-LINER:
A live-action feature inspired by the classic fairy tale, "Cinderella" brings to life the timeless images from Disney's 1950 animated masterpiece as fully-realized characters in a visually-dazzling spectacle for a whole new generation.
OFFICIAL BOILERPLATE:
Directed by Academy Award® nominee Kenneth Branagh ("Thor," "Hamlet") and starring two-time Academy Award winner Cate Blanchett ("Blue Jasmine," "Elizabeth"), Lily James ("Downton Abbey"), Richard Madden ("Game of Thrones") and Academy Award nominee Helena Bonham Carter ("The King's Speech," "Alice in Wonderland"), "Cinderella" is produced by Simon Kinberg ("X-Men: Days of Future Past," "Elysium"), Allison Shearmur ("The Hunger Games: Mockingjay, Part 1") and David Barron ("Harry Potter and the Deathly Hallows: Part 1") with Tim Lewis ("Edge of Tomorrow") serving as executive producer. The screenplay is by Chris Weitz ("About a Boy," "The Golden Compass").
"Cinderella" will be released through Walt Disney Studios Motion Pictures on March 13, 2015.
Filed Under: DISNEY MOVIES, MOVIE RELEASE DATES
« Never Before-seen Interviews with the Cast and Filmmakers for Disney's MCFARLAND, USA
Cartoon Network's Clarence: Mystery Piñata Released on DVD 2/10 »


text:
Q: delete from three tables Please Anyone there
if any conditions or query
i need to delete the details are matching accroding to
Table adl_auth_user A
id      user_id     type_id     type_value
66428     1919          1           97

table user_details B
user_id     first_name      last_nam
1919        Rins TE       Kola

table adl_user C
id         email                   password
1919    email@DOMAIN.COM         SOME PASSWORD

i want delete from these three

tables table1. user_id = table2.
> user_id and table1. user_id = table3.id

and group by

table1.type_id,table1.type_value

A: try this . delete the records from table according to the table dependencies.
i think grouping is not required as you are trying to delete the records

DELETE FROM adl_auth_user
from adl_auth_user  A
INNER JOIN user_details  B ON a.user_id=B.user_id
INNER JOIN adl_user  C ON b.user_id=c.id
WHERE A.user_id =1919 AND A.type_id =1

DELETE FROM user_details
FROM user_details B
INNER JOIN adl_user C ON b.user_id=c.id
WHERE B.user_id =1919

DELETE FROM adl_user
WHERE adl_user .id =1919

redpajama_set_name: RedPajamaStackExchange


text:
Capitol Hill: Open Doors USA CEO calls out major abuses against Christians
June 28, 2019 by Lindy Lowry in Advocacy
On the heels of the release of the 2018 International Religious Freedom report, the Tom Lantos Human Rights Commission convened a congressional hearing to focus on the right to religious freedom, specifically for minority Christian populations worldwide. As one of four speakers asked to offer testimony and recommendations for U.S. policy, Open Doors USA CEO David Curry spoke on the plight of global Christians. The hearing, hosted by the commission's co-chairmen Christopher H. Smith and James P. McGovern, also included remarks by Sam Brownback, Ambassador-at-Large for International Religious Freedom.
Below, we share Curry's testimony during this important hearing on Capitol Hill. He began his remarks by introducing everyone in the room to Zauna, a widow in Nigeria.
Today I'd like to tell you about Zauna. She is a widow. Her husband was one of the over 3,700 individual Christians who were killed in Nigeria due to their faith last year. Zauna's village has been attacked three times by Boko Haraman extremist group that is located primarily in Northern Nigeria More. Before the Boko Haraman extremist group that is located primarily in Northern Nigeria More attacks started, Zauna lived a relatively peaceful life as a farmer with her husband and children.
One night, militants entered Zauna's village near midnight. Somehow, Boko Haraman extremist group that is located primarily in Northern Nigeria More collected the names of many of the villagers before the attack. They called out names of specific people in the village—so that the village people would think they were friendly. But they were luring them out of their homes to kill them.
The militants eventually entered Zauna's home by force. They took her husband and pushed him back into their home. Zauna was able to slip away in the night; she hid behind a wood pile near their home. Then she saw the members of Boko Haraman extremist group that is located primarily in Northern Nigeria More light the roof of her house on fire with Zauna's husband locked inside. She escaped with her life, but lives with the trauma of seeing her husband burned alive in their own home.
Watch the hearing here. If the video doesn't begin at David Curry's introduction, skip to the 2:38:42 mark.
Persecution Rising
More must be done to help people like Zauna. Although Zauna's story is horrific, it is not isolated. On the contrary, it is emblematic of a far wider issue that impacts hundreds of millions of men, women and children around the world.
For over 25 years, Open Doors has released the World Watch List documenting violations against Christians. We can only verify data that's related to religious intolerance. Therefore, it should always be seen as a conservative baseline of religious persecution. 4,146 Christians were killed for their faith last year. 11 Christians were killed, on average, every day. Additionally 2,625 Christians were detained without trial, arrested sentenced and imprisoned. Over 1,266 churches were attacked.
This data is carefully collected through networks established throughout more than 70 countries over the past six decades. It is often reported or verified directly by our in-country field offices, who maintain regular contact with both survivors of religious persecution and the wider Christian community in their area.
Sadly, the number of violent incidents against Christians documented last year represents a dramatic rise over recent years. We believe it can be attributed to the following factors:
First, the spread of Islamic jihadist ideology. In Nigeria, Somalia, Afghanistan, Syria, Iraq and elsewhere, theologies of hatred toward Christians are widely propagated, leading to great suffering.
Second, the rise of nationalist agendas in Asia. India is 10th on the World Watch List because nationalist Hindu leaders are stoking the idea that Muslims and Christians cannot be truly Indian. That ideology has resulted in a shocking rise of attacks in Christian churches, with nearly 300 churches attacked thus far in 2019 and hundreds of cases of pastors held without trial—just for being Christian pastors.
Lastly, communist and post-communist systems. North Korea is the most oppressive place on earth to practice religious faith. Anything and anyone who challenges the leadership of the Kim regime is considered an enemy of the state. Many are imprisoned for their faith for even possessing a Bible. With over 100 million Christians, China also has the technology and political will to monitor and restrict expressions of faith like never before.
More Must Be Done
While Open Doors is working tirelessly to bring relief to those who suffer from severe religious freedom violations, more must be done to address the underlying factors that allow violations of religious freedom to occur in the first place. This is where the United States, including Congress and the executive branch, can play a pivotal role.
I have a few recommendations I'd like to offer, but first, I want to commend Chairman Smith and the Tom Lantos Human Rights Commission for holding this important hearing. Hearings of this kind are a fundamental key to shining the spotlight on abuses and lay the necessary groundwork for advancing international religious freedom.
To better address religious freedom violations globally, both against Christians and other communities, we would prioritize the following recommendations:
The U.S. State Department must ensure that Foreign Service Officers, detailees, and other appropriate staff at U.S. embassies and posts overseas are provided with, and required to, dedicate sufficient time and resources to develop a thorough understanding of religious freedom conditions in their respective postings and to build robust networks with faith actors in-country.
This should be beyond the minimum time and resources required to draft their respective sections of the annual International Religious Freedom report. While there are many dedicated state department personnel who invest thoroughly in these issues, all too often our frontline diplomats are not allowed to, or not asked to, build the necessary networks and expertise needed to address the many grave religious freedom concerns that exist in their postings.
We also strongly recommend that President Trump and Secretary Pompeo consider a more robust implementation of the Country of Particular Concern designations provided for by the International Religious Freedom Act. By statute, the administration is required to issue these designations 90 days after the release of the annual International Religious Freedom report. We urge the administration to seriously weigh options for targeted sanctions against individuals and foreign government entities responsible for systematic, ongoing, and egregious violations of religious freedom around the globe.
Today, Zauna has rebuilt her house, a small one-room hut, and her husband is buried inside. She farms her land, and she is thankful to God that she is alive. Yet she is traumatized and deeply misses her husband. She asks for your prayers.
There is much more yet to do to support Zauna. We look forward to working with this Commission and others in Washington to ensure that her story, and the many other stories like hers, are not forgotten.
Thank you for this opportunity to share with you today.


A must have for all Potter fans. Unleash the magic this Christmas with these modern designed Christmas cards.
The first design – a nod to all things Gryffindor and Harry's love of quidditch. For those who know where to look the Hallows are always there.
The second design – Its time to deck the halls with Professor Flitwick in the Great Hall.


"What's the fastest way of doing this?" – you might ask yourself during development. Sure, you can guess what's fastest or how long something will take, but do you know? How long does it take to sort a list of 1 Million elements? Are tail-recursive functions always the fastest? Benchmarking is here to answer these questions. However, there are many pitfalls around setting up a good benchmark and interpreting the results. This talk will guide you through, introduce best practices and show you some surprising benchmarking results along the way.


Using Point is extremely simple: when the user hovers the cursor over a word, Point displays a small box containing symbols illustrating the meaning of the word. Learn more about Point here.
Unfortunately, we are not able to provide subtitled videos or audio transcripts for this resource quite yet. However, if you would like transcripts of any of the videos or audios, please email send@lgfl.net with information on which ones you would like, and we will aim to send them to you as quickly as possible.
We have included these films and digital packs tackling the difficult subject of self-harm, since our research has shown these are a common issue in schools which staff are dealing with more often than ever before. We know some staff can often feel they lack the knowledge and training to deal with such issues confidently.
There are three different films and packs, one for staff, one for parents and one for pupils, all of which are voiced by real people sharing their real experiences.
Do ensure that you are familiar with the resources before you use them.
Do tailor the session and resources for the group; some slides may need to be removed or edited depending on the age of the learners you teach.
Do ensure that staff have gone through this staff CPD section and advice provided by Young Minds before delivering any support to young people or other staff. Many resources are accompanied by advice, notes and session outlines to support staff delivery of these often sensitive issues. Students and staff may be affected by topics you cover and it is essential to be fully aware of Young Minds' advice and your school policies and procedures in these areas.
Do ensure you are aware of any needs within the group and talk to pastoral, inclusion or other staff as appropriate as required if necessary. Students or staff may have personal experience of some areas covered and it is important to be sensitive to this.
Do ensure that staff are aware of topic you are covering in the session before hand in case any topics are challenging for them. Please ensure they are aware of support procedures and staff within the school as necessary.


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Appointment of Allen W. Locke as Deputy Staff Secretary of the White House
The President today announced the appointment of Allen W. Locke of Washington, D.C., as Deputy Staff Secretary of the White House.
Mr. Locke's previous government experience includes assignments in the Department of Defense and in the Department of State, where he most recently worked on international nuclear energy issues.
In his new post Mr. Locke will provide staff support to the President and help ensure effective communication and staffing among offices of the White House and the Executive Office of the President.
Mr. Locke, 42, was reared in Wellesley, Mass. He is a graduate of the University of Massachusetts (B.A., 1961; M.A., 1965). He is married to the former Elizabeth Gentry Heun of Washington, D.C. They have three children: Emily, Caroline, and William.


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Boston • Festival • Massachusetts • Street Parade • Traditional Events
Wake Up the Earth Festival 2021
Where: Southwest Corridor Park, Boston, Massachusetts, United States
When: Saturday, May 1, 2021 - Estimated date!
Photo: www.spontaneouscelebrations.org
The Wake Up the Earth Festival began in 1979 when a group of local neighbors and activist banded together to stop the Interstate 95 expansion into Jamaica Plain.
The festival began as, and still is, a celebration of what can be accomplished when people of all traditions, cultures, ages, and beliefs come together.
A great many individuals, local artists, community groups, and schools join forces every year to make a unique community collaboration.
Recent festivals have included an enchanted puppet forest, side shows, live bands, dancers, acoustic performers and a giant pageant.
[Courtesy of www.spontaneouscelebrations.org]
For accommodations, check the most recommended hotels in Boston and around, most of them suggest FREE CANCELLATION option or NO PREPAYMENT NEEDED – PAY AT THE PROPERTY:
Accommodations around Boston:
Spontaneous Celebrations
45 Danforth St., Jamaica Plain, MA 02130
info@spontaneouscelebrations.org
North America, bordering both the North Atlantic Ocean and the North Pacific Ocean, between Canada and Mexico
United States background and overview
Britain's American colonies broke with the mother country in 1776 and were recognized as the new nation of the United States of America following the Treaty of Paris in 1783. During the 19th and 20th centuries, 37 new states were added to the original 13 as the nation expanded across the North American continent and acquired a number of overseas possessions. The two most traumatic experiences in the nation's history were the Civil War (1861-65), in which a northern Union of states defeated a secessionist Confederacy of 11 southern slave states, and the Great Depression of the 1930s, an economic downturn during which about a quarter of the labor force lost its jobs. Buoyed by victories in World Wars I and II and the end of the Cold War in 1991, the US remains the world's most powerful nation state. Since the end of World War II, the economy has achieved relatively steady growth, low unemployment and inflation, and rapid advances in technology.
42.35843°
Kite and Bike Festival 2021
BostonMassachusettsUnited States
Wilco's Solid Sound Festival 2021
North AdamsMassachusettsUnited States
Boston Extreme Beer Fest 2021
Annual Boston Harborfest 2021
Puerto Rican Festival of Massachusetts 2021


Toward this end ERSA has been mandated by its Board to publish a Working and Policy Paper series, provide financial incentives to researchers to publish their papers in peer reviewed scholarly journals, run a Workshop programme across a range of distinct focus areas in economics, and to provide support to graduate students in economics in Southern Africa.
The Working and Policy Paper series has grown to a total of 739 published papers. Approximately 64 papers are appearing in the series each year, while the peer review process that selects the papers for publication referees considerably more contributions. The volume of publication, the width of coverage of sub-fields of economics, and the range of methodologies represented in the ERSA Working and Policy Paper series is unmatched by any other working paper series in Southern Africa.
The success rate of ERSA Working Papers appearing in scholarly journals also continues to rise steadily. The number of published papers has reached 351 (a 48% publication rate – high for any working paper series), of which 222 have appeared in international journals, and 129 in national journals. The high publication rate of the Working Paper series reflects the quality of referee input in helping to ready papers for peer review in journals, as well as the quality of the papers that are being published under ERSA's auspices.
A consistent objective of ERSA has been to ensure that the research that it publishes has a policy impact. Toward this end, since 2015 ERSA has published a Research Brief series, issued once a week (though the series existed in more infrequent issues since 2013). This presents summary results from research, in concise and non-technical form. The series is circulated to the full ERSA database of email contacts and is published on the website and by social media. Over the period to the close of the financial year, a total of 140 Research Briefs have been circulated.
Workshop activity During 2017-2018, 5 events/workshops were held, and attendance at the workshops continues to represent a diverse representation of national institutions and demographics. A total of more than 63 institutions, of which 21 were South African, have been represented at ERSA workshops during this reporting period.
Under the ERSA scholarship scheme, a total of 65 scholarships have been awarded to date, 62 for Masters, and 3 for PhD study. During the course of 2017-2018, 9 scholarship awardees fulfilled the final clause of their contract by submitting their final thesis to the ERSA Working Paper Series.
The Skills Development Initiative, which is aimed at raising the technical skills of young faculty members for an active research career, continues with the third cohort having completed their final workshop on Panel Data Analysis in Nov 2017. Meanwhile the 4th cohort attended their first workshop on Time Series Techniques in July 2017 to be followed by their 2nd workshop on Cross-Sectional Techniques scheduled for July 2018.
Under the Measuring Institutions Project, a full report can be found on Page 66 of the Annual Report.
ERSA has benefited from the time, effort, and contributions of many people. We thank particularly the ERSA Office team of Gloria Halland and Megan Gelderbloem have distinguished themselves by their efficiency and dedication without none of our operations would be feasible. We also want to thank Yoemna Mosaval, who resigned in October 2017, for her exceptional contribution over many years to the organization: she performed the difficult task of dealing with vainglorious academics with kindness and humor, always teaching us the values of humility and respect.


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2 November 2012 - Statement to the United Nations General Assembly Fourth Committee
UNITED NATIONS GENERAL ASSEMBLY FOURTH COMMITTEE
Peacekeeping Operations
Statement by Colonel Roger Barrett, Military Attaché of the Permanent Mission of Canada to the United Nations on behalf of Australia, Canada and New Zealand (CANZ)
Mr. Chairman,
I have the honour to deliver this statement on behalf of the CANZ group of countries – Canada, Australia and New Zealand.
CANZ would like to note the participation of Ms. Ameerah Haq in our discussion yesterday and to extend her a formal and warm welcome, as Under-Secretary General for the Department of Field Support. CANZ wishes to highlight that Mme Haq's position will be key to bringing about an agenda for reform in the field of peacekeeping. Her operational credentials are impressive and she can count on the full support of the CANZ membership. I would also like to thank her and the Under-Secretary General for Peacekeeping Operations, Monsieur Hervé Ladsous for their informative presentations and dialogue with Member States.
UN peacekeeping relies on the tireless work of men and women who are willing to deploy into difficult situations. CANZ wishes to pay tribute to all the men and women who have died or been injured in the course of conducting these often complex and challenging missions. Their sacrifice is a reminder of the importance of the issues that we are discussing here today.
For missions to be effective, they require planning, preparation and partnership. A comprehensive approach to mission planning is required to ensure mission mandates are clear and achievable, and that they have the resources and capabilities required to implement them. Peacekeepers need to be provided with the necessary guidance and training to prepare them for their roles and responsibilities in the field. And an active partnership between all stakeholders – the host government, Security Council, Secretariat, and Member States – is needed to raise awareness of ground realities, manage expectations, and support the overall goals of the mission.
CANZ welcomes the substantial progress made in the last couple of years to develop and operationalize the Protection of Civilians in peacekeeping operations. We support the progress in designing the tools needed to support peacekeepers in their efforts to protect civilians, including training modules on the "Protection of Civilians and prevention and response to conflict-related sexual violence"; a framework to assist with the development of mission-specific strategies, and a matrix to assist in the identification of the necessary resources and capabilities. Attention must continue to focus on the rollout and operationalization of these tools, as well as evaluating their impact in the field.
There are often high expectations of uniformed personnel when it comes to protecting civilians from the imminent threat of violence. CANZ welcomes ongoing work to develop further baseline guidance for military and police components, which we hope will assist them in undertaking these responsibilities. Civil affairs officers, community liaison assistants, joint protection teams, and community alert networks, perform a vital role in understanding the needs of the local communities and providing early warning of the threats they face. Such innovative practices provide valuable lessons. CANZ welcomes efforts to share these best practices and lessons learned from the field.
When a peacekeeping mission is deployed with a protection of civilians mandate, the responsibility to protect the civilian population remains, first and foremost, with the host government. Planning is required to ensure sufficient attention and resources are devoted to building the capacity of the host authorities. Tasks such as security sector reform and strengthening rule of law institutions are central to protection efforts in the longer term.
Mr. Chairman, (Peacekeeping Transition, Nexus of peacekeeping and peacebuilding).
In addition to protecting civilians, peacekeepers serve as early peacebuilders in many other areas, completing tasks that support political processes, security sector reform and capacity building. CANZ welcomes the development of the strategy on early peacebuilding support tasks for peacekeepers and encourages the better articulation of the types of tasks that peacekeepers can undertake to support peacebuilding efforts. It is important that all actors coordinate effectively on early peacebuilding tasks undertaken within a mission. Planning should be conducted throughout the mission lifecycle to ensure a smooth transition following a mission's departure. Such planning and coordination must be guided by the host nation to ensure strong national ownership and responsiveness to local needs.
Lastly, appropriate Rule of Law elements must exist within a Mission, and need to be addressed in a cohesive and timely manner. Also, in order to sustain the early gains , it is imperative that the United Nations and Member States ensure a smooth transition out of peacekeeping into a reconfigured United Nations presence. In this context, CANZ welcomes efforts to enhance and consolidate United Nations support for Rule of Law through the establishment of a joint focal point arrangement between DPKO and UNDP.
CANZ maintains the importance of accurately take into account women's experiences of conflict, as well as that of girls and boys. Regrettably, we have witnessed a dramatic decrease in the percentage of women in senior positions in political, peacebuilding and peacekeeping missions of the UN. We have further seen sexual violence, including rape as a weapon of war, and the threat of sexual violence continues to be used as a weapon of conflict in places like Cote d'Ivoire, the DRC, Libya, Syria and northern Mali.
Actions can be taken to address this situation. For example, this means ensuring the inclusion of clear instructions, directives and guidance on the protection of the human rights of women and girls in the operational directives of peacekeeping missions. This also includes the implementation of women, peace and security resolutions within the framework of mission drawdown and transitions. CANZ looks forward to the implementation of DPKO's forward-looking strategy on women, peace and security, and the further deployment of women protection advisors in the field.
The most valuable resources to any mission are its people and the important skills and capabilities they bring to each mission. CANZ supports the ongoing efforts being made by the UN Police Division, including through the regional consultations with PCCs, to standardise the roles of Police within the Mission environment through the Strategic Guidance Framework. Of course standardised roles are only as effective as the Officers deployed within a Mission. With the developing sophistication of United Nations Police activity, it is essential that the basic selection standards for Officers being deployed across UN Missions keep pace with performance expectations.
Peacekeepers frequently deploy into environments that pose a risk to their safety and security, as well as the populations they are frequently mandated to protect. To support their preparation, CANZ recognises the need for continued dialogue and progress on deterrence, use of force, and operational readiness. CANZ looks forward to further progress regarding the development of guidance on deterrence and use of force, as well as the conceptual framework for the operational readiness evaluation of military contingents and force headquarters.
Personnel also require mobility to effectively address these threats, often over extremes of terrain and distance. CANZ considers that generating resources and sustaining them over the course of the missions' mandates remains a critical challenge that needs to be addressed. Shortage of military helicopters in MONUSCO and UNMISS are a clear indication of the challenges that the UN is facing in its biggest missions, especially when it relates to critical priority mandated tasks, including the protection of civilians.
Critical enablers that provide mobility and assist with gathering timely and accurate information not only assist with the implementation of mission mandates, but more importantly, provide vital support to enhance the safety and security of personnel.
CANZ believes that modern technologies, including short take-off and landing aircraft, and unmanned aerial vehicles, should be considered when assessing mission capability and resource requirements. Such technologies should be implemented in a transparent manner, in consultation with the host government. CANZ looks forward to the Secretariat's proposals in this regard.
In the context of the establishment of a "capability-driven approach", CANZ is also interested in completing the development and implementation of component-specific approaches to the development of baseline capability standards, in particular related to infantry battalions, staff officers and medical support units. CANZ looks forward to training materials in support of these pilot projects being finalized and delivered to peacekeeping training institutes and Member States. We also encourage the Secretariat to consider other components of peacekeeping that would benefit from the establishment of capability standards.
CANZ welcomes the ongoing work of the UN Secretariat to develop training materials and standards to support Member States deploying troops and police to missions, as well as to further professionalise the work of civilian personnel, including civil affairs officers. We look forward to receiving an update on the peacekeeping training needs assessment in the near future. We hope the assessment will assist in developing a comprehensive, coherent and coordinated approach to peacekeeping training among Member States, training institutes, and the UN Secretariat.
As operations inherently rely upon support activities to maximize effectiveness, CANZ believes that the Global Field Support Strategy (GFSS) has already proven its worth in improving support timeliness, efficiency and accountability of peacekeeping operations. Nonetheless, the GFSS would clearly benefit from an end state vision before finalising certain of its key elements.
In this regard, CANZ supports Ms.Haq's approach to wait until the current Regional Service Centre in Entebbe has demonstrated its strengths, before implementing further regional service centres. While we understand that the challenges of the C-34 to conclude its report has somewhat disturbed regular bimonthly scheduled briefings to the C-34 on the GFSS implementation, it would be useful for the Secretariat to resume these regular briefings. In this context, CANZ is looking forward to the upcoming third GFSS progress report.
We continue to see the value of partnerships among all stakeholders to ensuring the overall success of UN peacekeeping. CANZ welcomes the conclusion of a final report by the Senior Advisory Group on troop reimbursement rates and other related issues. We hope it will have a positive impact on our collective ability to deal effectively with the numerous peacekeeping policy issues that require our attention.
As this year's C-34 consultations demonstrated, our annual C-34 reports are increasingly lengthier, and consensus has become more difficult. CANZ believes the C-34 has an important contribution to make to the overall direction of UN peacekeeping policy. We have had considerable time this year to reflect on our current working methods and what we want the Special Committee to achieve. We need to continue our dialogue on these issues in the coming months to ensure that our previous challenges in finalising our annual reports do not have a detrimental impact on the overall direction of peacekeeping policy and our operations in the field.


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Ballplayers: Bearded Or Baby-Faced?
By Jack Kennedy
Ever since Jayson Werth dawned his Chewbacca-esque beard, players have been growing them in droves. Players like Jake Arrieta and Jose Bautista come to mind when I think of those with the most powerful facial hair in the game, but does it matter in terms of ability? Does having a beard make you better at hitting a baseball?
In order for someone to answer that, they would have to look over nearly every MLB team's active roster and handpick the important stats for comparison, but who has that kind of time? Lucky for you, I do. After spending a strenuous seven hours looking through major league players, I have determined the average stats, both regular and advanced, that each group of hitters produces. (maybe determining pitching stats will come later?) For qualification, I considered the size of the beard… and that's basically it. If you have to look at it and think "does this count as facial hair?" the answer is no. Let me put it this way…
Khris Davis:
Yuli Gurriel:
If it looks like it's just a weird shadow or possibly leftover food, then no. If it looks like a high schooler doing his best, I'll give it to 'em.
Now that we have the very rigid qualifications out of the way, let's get into some speculation. Personally, as a bearded individual myself, I believe that having a beard will marginally improve one's play. My theory goes beyond personal bias. Those with facial hair have more testosterone, and the thicker the hair the more the testosterone. Because testosterone is associated with muscle growth and even competitive nature, it would not be far fetched to assume that facial hair as a result of more testosterone would lead to a more driven and athletic ball player. While obviously, nearly all ballplayers can grow a beard, the ones who truly embrace it are the subjects of my test. Below I have compiled the results of my findings.
Bearded Players
Clean Shaven Players
For the most part, it's about even between the two, but the clean-shaven players have a slight advantage in games played, home runs, RBIs, runs, and a decently substantial advantage in WAR coming in .3 above their bearded peers. The averages table breaks down below:
GP BA OBP SLG HR RBI's Runs wOBA WAR
Bearded 95.51 0.2442 0.3124 0.409 11.878 44.989 42.474 0.3271 1.3323
Clean Shaven 101.65 0.2425 0.3163 0.402 13.080 52.878 45.424 0.3198 1.6070
However, this does not tell a complete story due to a 6 game difference in games played. Because of this, it is important to factor in the stats for a full season over 162 games:
GP HR RBI's Runs WAR
Bearded 162 20.1472 76.3058 72.0399 2.252
Clean Shaven 162 20.8455 84.2676 72.3881 2.561
While there is still an advantage in RBI's, the other season-long stats seem to normalize themselves a lot closer to each other, and the two types of hitters seem to be a lot closer in value until you get to WAR. In terms of WAR, there is still a large lead for the clean-shaven players. While conventional numbers show they are roughly the same an entire .3 lead in WAR is enough for me to say that players who are clean-shaven are in fact better ball players.
So yes, contrary to my original opinion and hope, having a beard most certainly hinders one's ability to play baseball, and K Zone Creator Mike Duffy says, "That's why the Yankees always win," although maybe the reason the clean-shaven players had an advantage is that the Yankees players are shaven and due to the level of talent they have they skew the data. Perhaps maybe bearded players are more precise in the way they carry out their daily lives, and baseball is a precision sport, but this is difficult to speculate on. It may be impossible to determine the reason for the advantage, but either way I know I will be shaving before my season starts.
jackmkennedy34
I watch 162 Phillies games a year, some call it a problem I call it dedication