Playwright, builder and compere Adrian Bunting passed away in May, one month after being diagnosed with pancreatic cancer. Before his death he put in place plans to construct Brighton Open Air Theatre (BOAT) in Dyke Road Park. SOURCE spoke to the BOAT crew.
Adrian was seldom without a cigarette and never without an opinion. In the early 90s he was founder, MC and ringmaster of the legendary Brighton cabaret Zincbar and he wrote, directed and produced the award-winning play Kemble's Riot. He was also a builder and construction manager, an inveterate inventor and an evangelical atheist with a robust interest in women, cryptic crosswords and croquet.
Why was Dyke Road Park chosen?
In April the council asked for ideas for the defunct bowling green. It was Adrian's local park for 25 years and he'd drawn up plans of the perfect theatre space, utilizing his considerable experience and his construction know-how to take on the problems of open air productions. When he fell ill he gathered his friends, described his vision, gave them his plans and asked them to see the BOAT to fruition. He left them £18,000 and his complete faith. Adrian died on 11 May, knowing the BOAT would float.
What will BOAT be like?
It will be the only open air theatre of its kind, lawned and landscaped, with state of the art sound and lighting, and other bespoke features. The planning process starts now and we're looking to launch the BOAT in time for next year's Brighton Festival.
How did the Dome benefit come together?
Adrian's friend Susan Murray put the show together in double-quick time. Ade managed Jo Neary for a while and knew all the performers from countless Edinburgh Festivals. The Dome have shown their support too and are giving us the venue at cost, bless them. Tickets are £20 and every penny goes to the BOAT.
How can people assist with the project?
The BOAT is for everyone. You can donate via our Facebook page (Facebook.com/BrightonOpenAirTheatre) or, better still, come along to the Dome show on the 16th.


text:
"A SULPHONAMIDE DERIVATIVE"
The present invention relates to new sulphonamide derivatives, with the general formula (I), as well as to their physiologically acceptable salts, the processes for their preparation, their application as medicaments in human and/or veterinary therapy and the pharmaceutical compositions that contain them.
A SULPHONAMIDE DERIVATIVES;
The present invention relates to new sulphonamide derivatives, with the general formula (I), as well as to their physiologically acceptable saits, the processes for their preparation, their application as medicaments in human and/or veterinary therapy and the pharmaceutical compositions that contain them.
The new compounds object of the present invention can be used in the pharmaceutical industry as intermediates and for preparing medicaments.
The superfamily of serotonin receptors (5-HT) includes 7 classes (5-HTi-5-HT7) encompassing 14 human subclasses [D. Hoyer, et al., Neuropharmacology, 1997! 36, 419]. The 5-HT6 receptor is the latest serotonin receptor identified by molecular cloning both in rats [F.J. Monsma, et al., Mol. Pharmacol., 1993, 43, 320; M. Ruat, et al., Biochem. Biophys. Res. Commun., 1993, 193, 268] and in humans [R. Kohen, et al., J. Neurochem., 1996, 66, 47]. Compounds with 5-HT6 receptor antagonistic activity are useful for the treatment of various disorders of the Central Nervous System and of the gastrointestinal tract, such as irritable bowel syndrome. Compounds with 5-HT6 receptor antagonistic activity are useful in the treatment of anxiety, depression and cognitive memory disorders [M. Yoshioka, et al., Ann, NY Acad Sci., 1998, 861, 244; A. Bourson, et al., Br. J. Pharmacol. , 1998, 125, 1562; D.C. Rogers, et al., Br. J. Pharmacol. SuppL, 1999, 127, 22P; A. Bourson, et al., J. Pharmacol. Exp. Then , 1995, 274, 173; A.J. Sleight, et al., Behav, Brain Res. ,
1996, 73, 245; T.A. Branchek, et al., Annu. Rev. Pharmacol. Toxicol, , 2000, 40, 319; C. Routledge, et al., Br. J. Pharmacol. , 2000, 130, 1606]. It has been shown that typical and;atypical antipsychotic drugs for treating schizophrenia have a high affinity for 5-HT6 receptors [B.L Roth, et al., J. Pharmacol. Bxp. Ther. , 1994, 268, 1403; C.E. Glatt, et al., Mol. Med. , 1995, 1, 398; F.J. Mosma, et a!., Mol. Pharmacol. , 1993, 43, 320; T. Shinkai, et al.. Am. J. Med. Genet , 1999, 88, 120]. Compounds with 5-HT6 receptor antagonistic activity are useful for treating infantile hyperkinesia (ADHD, attention deficit / hyperactivity disorder) [W.D. Hirst, et al., Br. J. Pharmacol. , 2000, 730, 1597; C. Gerard, et al., Brain Research, 1997, 746, 207; M.R. Pranzatelli, Drugs of Today, 1997, 33, 379]. Patent application WO 01/32646 describes sulphonamides derived from bicycles, with 6 members each, aromatic or heteroaromatic with 5-HT6 receptor antagonistic activity. Patent application EP 0733628 describes sulphonamides derived from indole with an 5-HTiF receptor antagonistic activity useful for treating migraines. In general, the study of the scientific literature and patents indicates that small structural variations give rise to agonist or antagonist compounds of various receptors of serotonin that are useful for treating different diseases, depending on the receptor for which they show affinity.
After laborious research the inventors have managed to synthesize new compounds with the general formula (I) that show interesting biological properties making them particularly useful for use in human and/or veterinary therapy.
The present invention provides new compounds with serotonin 5=HI6 receptor antagonistic activity useful in the. preparation of a medicament for prevention or treatment of various.disorders. of the Central Nervous System, and in particular anxiety, depression, cognitive memory disorders and senile dementia or other dementia processes in which there is a predominant cognition deficit, psychosis, infantile hyperkinesia (ADHD, attention deficit / hyperactivity disorder) and other disorders mediated by the serotonin 5-HT6 receptor in mammals, including man.
The compounds object of the present invention have the general formula (I)
R1 represents hydrogen, a C1-C4 alkyl radical or a benzyl radical;
n represents 0, 1, 2, 3 or 4;
R2 represents -NR4R.5 or a group with formula:
wherein the dotted line represents an optional chemical bond;
R3, R4 y R5 independently represent hydrogen or a C1-C4 alkyl;
X, Y and Z independently represent hydrogen, fluorine, chlorine, bromine, a C1-C4
alkyl, a C1-C4 alkoxy, a C1-C4 alkylthio, trifluoromethyl, cyano, nitro and -NR4R5;
W represents a bond between the two rings, CH2, O, S and NR4;
m represents 0, 1, 2, 3 or 4;
with the proviso that when m = 0, A is a substituted phenyl;
or one of its physiologically acceptable salts.
The alkyl term C1-C4 represents a linear or branched hydrocarbon chain including 1 to 4 atoms of carbon, such as methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl and tert-buty\.
Compounds object of the present invention that correspond to the above formula can be selected from among:
[1] N-[3-(2-diethylaminoethyl)-1H-indol-5-yl]-5-chloro-3-methylbenzo[b]thiophene-2-
sulphonamide.
[2] N-[3-(2-diethylaminoethyl)-1 H-indol-5-yl]naphthalene-1 -sulphonamide.
[3]N-[3-(2-diethylaminoethyl)-1H-indol-5-yl]naphthalene-1-sulphonamide
hydrochloride.
[4] N-[3-(2-diethylaminoethyl)-1H-indol-5-yl]-3,5-dichlorobenzenesulphonamide.
[5] N-[3-(2-diethylaminoethyl)-1H-indol-5-ylH-phenylbenzenesulphonamide.
[6] N-[3-(2-diethylaminoethyl)-1H-indol-5-yl]-5-chlorothiophene-2-sulphonamide.
[7] N-[3-(2-dimethylaminoethyl)-1H-indol-5-yl]-5-chloro-3-methylbenzo[b]thiophene-
2-sulphonarnide.
[8] N-[3-(2-dimethylaminoethyl)-1 H-indol-5-yl]naphthalene-1 -sulphonamide.
[9] N-[3~(2-dimethylamino-ethyl)-1 tf-indol-5-ylj-6-chloroimidazo[2,1 -b]thiazol-5-
[10] N-[3-(1-methylpiperidin-4-yl)-1 H-indol-5-yl]-5-diioro-3-methylbenzo[b]thiophene-
2-sulphonamide.
[11] N-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]-5-chloro-3-methyibenzo[b]thiophene-
2-sulphonamide hydrochloride.
[12] N-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]naphthalene-1-sulphonamide.
[13] N-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]naphthalene-1-sulphonamide
[14] N-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]-5-chlorothiophene-2-sulphonamide.
[15] N-[3-(1 -methylpiperidin-4-yl)-1 H-indol-5-yl]-4-phenylbenzenesulphonamide.
[16] N-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]quinoline-8-sulphonamide.
[17] N-[3-(2-diethylaminoethyl)-1 H-indol-5-yl]naphthalene-2-sulphonamide.
[ISJN-ES-fi-methyl-I^.S.e-tetrahydropyridin^-yO-IH-indol-S-yllnaphthalene-i-
[19]N-[3-(4-methylpiperazin-1-yl)methyl-iH-indol-5-yl]-5-chloro-3-
methylbenzo[b]thiophene-2-sulphonamide.
[20] N-[3-(2-dimethylaminoethyI)-1H-indol-5-yl]-5-(2-pyridil)thiophene-2-
[21]N-[3-(2-dimethylaminoethyl)-1H-indol-5-yl]-2,1,3-ben2othiadiazol-4-
[22] N-[3-(2-dimethylaminoethyl)-1H-indol-5-yl]quinoline-8-sulphonamide.
[23] N-[3-(2-dimethylaminoethyl)-1/-/-indol-5-yl]-5-chloronaphthalene-2-
[24] N-[3-(2-dimethylaminoethyl)-1H-indof-5-yl]-4-phenoxybenzenesulphonamide.
[25] N-[3-(2-dimethylaminoethyl)-1H-indol-5-yl]-4-phenylbenzenesulphonamide.
[26] N-[3-(2-diethylaminoethyl)-1H-indol-5-yl]-N-ethyl-naphthalene-2-sulphonamide.
[27] N-{3-[2-(morpholin-4-y|)ethyl]-1 H-indol-5-yl}-5-chloro-3-
[28] N-{3-[2-(morpholin-4-yl)ethyl]-1 HHndoi-5-yl}naphthalene-1 -sulphonamide.
[29]N-[3-(2-diethylaminoethyl)-1H-indol-5-yl]naphthalene-2-sulphonamide.
[30] N-[3-dimethylaminomethyl-1H-indol-5-yl]-5-chloro-3-methylbenzo[b]thiophene-
[31] N-[3-(2-dipropylaminoethyl)-1H-indol-5-yl]naphthalene-1-sulphonamide.
" [32] N-[3-(2-dipropylaminoethyl)-1 H-indol-5-y!]-5-chloro-3-methylbenzo[b]thiophene-2-sulphonamide.
[33]N-[3-(2-dibutylaminoethyl)-1H-indol-5-yl]-5-chloro-3-methylbenzo[b]thiophene-2-sulphonamide.
[34] N-[3-(2-dibutylaminoethyl)-1 H-indol-5-yl]naphthalene-1 -sulphonamide. [35] N-[3-(2-diethylaminoethyl)-1 H-indol-5-yl]-5-chloronaphthalene-1 -sulphonamide. [36] N-[3-(2-diethylaminoethyl)-1H-indol-5-yl]-trans-p-styrenesu!phonamide. [37] N-[3-(4-methylpiperazin-1 -yl)methyl-1 H-indol-5-yl]-trans-p-styrenesulphonamide.
[38]N-[3-(octahydroindolizin-7-yl)-1.H-indol-5-yl]-5-chloro-3-methylbenzo[b]thiophene-2-sulphonamide.
[39]N-[3-(2-diethylaminoethyl)-1H-Jndol-5-yl]-6-chloroimidazo[2,1-b]thiazol-5-sulphonamide.
[40] N-{3-[2-(morpholin-4-yl)ethyl]-1H-indol-5-yl}naphthalene-2-sulphonamide. [41] N-[3-(4-methylpiperazin-1-yI)methyl-1H-indol-5-yl]-a-toluenesulphonamide. [42] N-[3-(3-diethylaminopropyl)-1H-indol-5-yl]naphthalene-2-sulphonamide. [43] N-[3-(3-diethylaminopropyl)-1H-indol-5-yl]-5-chloro-3-methylbenzo[b]thiophene-2-sulphonamide.
[44]N-{3-[2-(pyrrolidin-1-yl)ethyl]-1H-indol-5-yl}-5-chloro-3-methylbenzo[b]thiophene-2-sulphonamide.
[45] N-{3-[2-(pyrrolidin-1 -yl)ethyl]-1 H-indol-5-yl}naphthalene-1 -sulphonamide. [46] N-{3-[2-(pyrrolidin-1 -yl)ethyl]-1 H-indol-5-yl}naphthalene-2-sulphonamide. [47] N-[3-(2-dipropylaminoethyl)-1H-indol-5-yl]naphthalene-2-sulphonamide. [48] N-[3-(2-dimethylaminoethyl)-1H-indol-5-yl]-5-chloronaphthalene-1-sulphonamide.
[49] N-[3-(2-dimethylaminoethyl)-1H-indol-5-yl]naphthalene-2-sulphonamide. [50] N-{3-[2-(morpholin-4-yl)ethyl]-1H-indol-5-yl}quinoline-8-sulphonamtde. ( [51 ] N-{3-[2-(morpholin-4-yl)ethyl]-1 H-indol-5-yl}-4-phenylbenzenesulphonamide. [52] N-[3-(4-methylpiperazin-1 -yl)ethyl-1 H-indol-5-yl]naphthalene-2-sulphonamide. [53] N-[3-(4-methylpiperazin-1 -yl)ethyl-1 H-indol-5-yl]-5-chloronaphthalene-1 -sulphonamide.
The present invention also relates to the physiologically acceptable salts of the compounds with the general formula (I), particularly the addition salts of mineral acids such as hydrochloric, hydrobromic, phosphoric, sulphuric, nitric acids, and of organic acids such as citric, maleic, fumaric, tartaric acids or their derivatives, p~ toluensulphonic acid, methansulphonic acid, camphorsulphonic acid, etc.
The new derivatives with the general formula (I), wherein R1 R2, R3, R4, n and A have the meanings indicated above, can be prepared according to the following methods:
METHOD A
By reacting a compound with the general formula (II) or one of its suitably protected derivatives
wherein A has the meaning indicated previously in the general formula (I) and X is an acceptable leaving group including a halogen atom, particularly chlorine;
with a 5-aminoindole with the general formula (III), or one of its suitably protected derivatives;
wherein n, R1, R2 and R3 have the meanings indicated previously in the general formula (I);
in order to obtain the corresponding sulphonamide and, optionally, removing from it the protective groups and / or forming a pharmacologically acceptable salt.
The reaction between the compounds with the general formula (II) and (III) is carried out in the presence of an organic solvent such as an alkyl ether, particularly diethyl ether, or a cycloalkyl ether, particularly tetrahydrofurane or dioxane, a halogenated organic hydrocarbon, particularly methylene chloride or
chloroform, an alcohol, particularly methanol or ethanol, an aprotic dipolar solvent, particularly acetonitrile, pyridine or dimethylformamide, or any other suitable solvent.
The reaction preferably is carried out in the presence of a suitable inorganic base such as hydroxides and carbonates of alkali metals, or in the presence of an organic base, particularly trrethylarnine or pyridine.
The most suitable reaction temperatures range from 0 ° C to room temperature, and the reaction time is between 5 minutes and 24 hours.
The resulting sulphonamide can be isolated by evaporating the solvent, adding water and eventually adjusting the pH so that it is obtained as a solid that can be isolated by filtration; or it can be extracted by a solvent immiscible with water such as chloroform and purified by chromatography or recrystallisation from a suitable solvent.
The compounds with the general formula (II) are commercially available or can be prepared according to standard methods or by methods analogous to those described in the literature [E.E. Gilbert, Synthesis, 1969, 1, 3] and the compounds with the general formula (III) can be prepared according to standard methods or by methods analogous to those described in the literature [J.E. Macor, R. Post and K. Ryan, Synt Comm., 1993, 23, 1, 65-72.; J. Guillaume, C. Dumont, J. Laurent and N. Nedelec, Eur. J. Med Chem., 1987, 22, 33-43; M.L Saccarello, R. Stradi, Synthesis, 1979, 727].
METHOD B
The compounds with the general formula (I), wherein R1, R2, R4, n and A have the meanings indicated above and R3 represents a C1-C4 alkyl, can be prepared by alkylation of a compound with the general formula (I), wherein R1, R2, R4, n and A have the meanings indicated above and R3 represents an atom of hydrogen, with an alkyl halide or a dialkyl sulphate.
The reaction preferably is carried out in the presence of a suitable base such as hydroxides and carbonates of alkali metals, metal hydrides, alkoxides such as sodium methoxide or potassium tert-butoxide, organometallic compounds such as butyl lithium or tert-butyl lithium, in the presence of an organic solvent such as an alkyl ether, particularly diethyl ether, or a cycloalkyl ether, particularly
tetrahydrofurane or clioxane, a hydrocarbon, particularly toluene, an alcohol, particularly methanol or ethanol, an aprotic dipolar solvent, particularly acetonitrile, pyridine or dimethylformamide, or any other suitable solvent. The most suitable temperatures are between 0 ° C and the boiling point of the solvent, and reaction times are between 1 and 24 hours.
The resulting sulphonamide can be isolated by concentrating the filtrate at reduced pressure, adding water and eventually adjusting the pH so that it is obtained as a solid that can be isolated by filtration, or it can be extracted with a solvent immiscible with water such as chloroform and purified by chromatography or recrystallisation from a suitable solvent.
METHOD C
By condensation of a compound with the general formula (I) wherein R1, R3, and A have the meanings indicated above, n=0 and R2 represents an atom of hydrogen, with a suitably substituted 4-piperidone the corresponding compound is obtained with the general formula (I) wherein R1, R3, and A have the meanings indicated above, n=0 and R2 represents a suitably substituted 1,2,3,6-tetrahydropyridine-4-yl radical.
The reaction can take place in both an acid and a basic medium, in a suitable solvent at temperatures between 25 and 150° C.
Suitable basic conditions include inorganic bases such as sodium or potassium hydroxide, or organic bases such as pyrrolidine or triethylamine in solvents such as methanol or ethanol. Preferably, solutions of sodium methoxide in methanol at reflux. Reaction times range from 1 to 48 hours.
Suitable acidic conditions include hydrochloric acid in ethanol or trifluoroacetic acid in acetic acid at temperatures between 50 and 100° C and reaction times ranging from 1 to 48 hours.
The resulting sulphonamide can be isolated by dilution in water, eventually adjusting the pH, to obtain it as a solid that can be isolated by filtration; or it can be extracted with a solvent immiscible with water such as chloroform and purified by chromatography or by recrystallisation from a suitable solvent.
The compounds with the general formula (I) wherein R1, R3, and A have the meanings indicated above, n=0 and R2 represents an atom of hydrogen, can be prepared according to the method A from a 5-aminoindole.
METHOD D
The compounds with the general formula (I) wherein R1t R3| and A have the meanings indicated above, n=0 and R2' represents a suitably substituted 4-piperidinyl radical, can be prepared by reducing a compound with the general formula (I) wherein R1f R3, and A have the meanings indicated above, n=0 and R2 represents a suitably substituted 1,2,3,6-tetrahydropyridin-4-yl radical prepared according to the: method C.
Hydrogenation takes place with the aid of a metallic catalyst such as palladium, platinum or rhodium on a support such as carbon, aluminum oxide or barium sulphate, preferably palladium over carbon, with an initial hydrogen pressure of between 1 and 10 atmospheres, preferably between 2 and 5 atmospheres, in a solvent such as methanol or ethanol. The reaction time ranges from 1 hour to 3 days.
The resulting sulphonamide can be isolated by filtering the catalyst and concentrating the filtrate at reduced pressure. The product recovered can be used as such or it can be purified by chromatography or by recrystallisation from a suitable solvent.
METHOD E
The pharmacologically acceptable salts of compounds with the general formula (I) can be conventionally prepared by reaction, with a mineral acid, such as hydrochloric, hydrobromic, phosphoric, sulphuric, nitric acids or with organic acids such as citric, maleic, fumaric, tartaric acids or their derivatives, p-toluensulphonic acid, methansulphonic acid, etc., in a suitable solvent such as methanol, ethanol, ethyl ether, ethyl acetate, acetonitrile or acetone and obtained with the usual techniques of precipitation or crystallisation of the corresponding salts.
During any of the synthesis sequences described, or in the preparation of the
sintones used it may be necessary and/or desirable to protect sensitive or reactive
groups in some of the molecules employed. This can be performed by means of
' conventional protective groups such as those described in the literature [Protective
groups in Organic Chemistry, ed J. F.W. McOmie, Plenum Press, 1973; T.W. Greene & P.G.M. Wuts, Protective Groups in Organic Chemistry, John Wiley & sons, 1991]. The protective groups can be removed in a suitable latter stage by known methods.
. The invention provides pharmaceutical compositions that comprise, in addition to an acceptable pharmaceutical excipient, at least one compound with the general formula (I) or one of its physiologically acceptable salts. The invention also relates to the use of a compound with the general formula (I) and its physiologically acceptable salts in the preparation of a medicament having serotonin 5HT6 receptor antagonistic activity, useful for preventing or treating various disorders of the Central Nervous System, and particularly anxiety, depression, cognitive memory disorders and senile dementia processes, and other dementias in which predominates a cognition deficit, psychosis, infantile hyperkinesia (ADHD, attention deficit / hyperactivity disorder) and other disorders mediated by the serotonin 5-HT6 receptor in mammals, including man.
The following examples show the preparation of novel compounds according to the invention. Also described is the affinity for the serotonin 5HT6 receptor, as well as galenic formulae applicable to the compounds object of the invention. The examples provided below are given for purposes of illustration only and should not restrict the scope of the invention in any way.
Example 7.- Preparation of N-[3-(2-dimethylarninoethyl)-1H-indol-5-yl]-5-
chloro-3-methyl-benzo[b]thiophene-2-sulphonamide.
To a solution of 3.05 g (15 mMol) of 5-amino-3-(2-dimethylaminoethyl)-1H-indole in 100 ml of pyridine is added dropwise at room temperature a solution of 4.21 g (15 mMol) of 5-chloro-3-methyl-benzo[b]thiophene-2-sulphonyl chloride in 20 ml of pyridine. The reaction mixture is stirred at room temperature for 20 hours. It is then evaporated to dryness, slightly alkalinised with diluted ammonia and dissolved in ethyl acetate. The organic phase is washed with water and a saturated solution of sodium bicarbonate, separated and dried with anhydrous sodium sulphate. The organic solution is evaporated to dryness and the resulting solid is repeatedly washed with ethyl ether, to yield 5.5 g (82%) of N-[3-(2-dimethylaminoethyl)-1H-indol-5-yl]-5-chloro-3-methyl-benzo[b]thiophene-2-sulphonamide as a solid with m.p.
= 226-227° C.
Example 26.- Preparation of N-[3-(2-diethylaminoethyl)-1H-indol-5-yl]-N-ethyl-naphthalene-2-sulphonamide.
To a mixture of 285 mg (0.7 mMol) of N-[3-(2-diethy1aminoethyl)-1H-indol-5-yl]naphthalene-2-sulphonamide (example 17) and 80 mg (0,7 mMol) of potassium t-butoxide in 3 ml of DMSO are stirred for 30 minutes at room temperature. Then 105 mg (0.7 mMol) of ethyl iodide are added and the solution is left with stirring for 3 hours. Water is added and the solution is extracted with ethyl acetate. The organic solution is evaporated to dryness and the resulting crude is purified by chromatography on silica gel, using as an eluent mixtures of methylene chloride/methanol/ammonia, yielding N-[3-(2-diethylaminoethyl)-1H-indol-5-yl]-N-ethyl-naphthalene-2-sulphonamide as a solid with m.p. = 49-50° C.
Example 18.- Preparation of N-p^i-methyl-I^.S.e-tetrahydropyridin^-yl)-1 H-indol-5-yl]naphthalene-1 -sulphonamide.
To a solution of 712 mg (13.2 mMol) of sodium methoxide in 100 ml of methanol, 850 mg (2.64 mMol) of N-[1/-/-indol-5-yl]naphthalene-1-sulphonamide are added, followed by 596 mg (5.28 mMol) of 1-methyl-4-piperidone and the resulting solution is heated to reflux for 48 hours. The reaction mixture is concentrated at reduced pressure and the residue obtained is purified by chromatography over silica gel, using as an eluent mixtures of methylene chloride/methanbl/ammonia, to yield 573 mg (52%) of N-[3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-5-yl]naphthalene-1 -sulphonamide as a solid with m.p. = 244-245° C.
Example 12.- Preparation of N-[3-(1 -methyl-piperidin-4-yl)-1 H-indol-5-yl]naphthalene-1 -sulphonamide.
To a solution of 417 mg (1 mMol) of N-[3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-5-yl]naphthalene-1-sulphonamide in 50 ml of
methanol, 100 mg of 5% palladium on carbon are added. The mixture is hydrogenated at room temperature at an initial hydrogen pressure of 3 atmospheres for 20 hours. The reaction mixture is filtered and the filtrate is concentrated at reduced pressure to provide a crude that is slurried in ethyl ether, yielding 272 mg (65%) of N-[3-(1 -methyl-piperidin-4-yl)-1 H-indol-5-yl]naphthalene-1 -sulphonamide as a solid with m.p.= 254-256° C
Example 3.- Preparation of N-[3-(2-diethylaminoethyl)-1H-indol-5-yl]naphthalene-1 -sulphonamide hydrochloride.
1.05 g (2.5 mMol) of N-[3-(2-diethylaminoethyl)-1H-indol-5-yl]naphthalene-1-sulphonamide (example 2) are dissolved in 10 ml of ethanol, and 0.6 ml of a 4.2 N solution of hydrochloric acid in ethanol are added. It is allowed to crystallise at room temperature. N-[3-(2-diethylaminoethyl)-1H-indol-5-yl]naphthalene-1-sulphonamide hydrochloride is obtained as a solid with m.p.= 255-257° C.
The melting point and spectroscopic data for identifying some of the compounds object of the present invention are shown in the following table:
BIOLOGICAL ASSAYS BINDING TO SEROTONIN RECEPTOR 5HT6
Cell membranes of HEK-293 cells expressing the recombinant human 5HT6 receptor were supplied by Receptor Biology. In said membranes the receptor concentration is 2.18 pmol/mg protein and the protein concentration is 9.17 mg/ml. The experimental protocol follows the method of B. L. Roth et al. [B. L. Roth, S. C. Craigo, M. S. Choudhary, A. Uluer, F. J. Monsrna, Y. Shen, H. Y. Meltzer, D. R. Sibley: Binding of Typical and Atypical Antipsychotic Agents to 5-Hydroxytryptamine-6 and Hydroxytriptamine-7 Receptors. The Journal of Pharmacology and Experimental Therapeutics, 1994, 268, 1403] with slight changes. The commercial membrane is diluted (1:40 dilution) with the binding buffer: 50 mM Tris-HCI, 10 mM MgCI2, 0.5 mM EDTA (pH 7.4). The radioligand used is [3H]-LSD at a concentration of 2.7 nM with a final volume of 200 ul. incubation is initiated by adding 100 ul of membrane suspension, (" 22.9 ug membrane protein), and is prolonged for 60 minutes at a temperature of 37° C. The incubation is ended by fast filtration in a Brandel Cell Harvester through fiber glass filters made by Schleicher & Schuell GF 3362 pretreated with a solution of polyethylenimine at 0.5 %. The filters are washed three times with three milliliters of buffer Tris-HCI 50 mM pH 7.4. The filters are transferred to flasks and 5 ml of Ecoscint H liquid scintillation cocktail are added to each flask. The flasks are allowed to reach equilibrium for several hours before counting with a Wallac Winspectral 1414 scintillation counter. Non-specific binding is determined in the presence of 100 uM of serotonin. Tests were made in triplicate. The inhibition constants (Kj, nM) were calculated by non-linear regression analysis using the program EBDA/LIGAND [Munson and Rodbard, Analytical Biochemistry, 1980, 107, 220]. The following table shows binding results for some of the compounds object of the present invention.
The daily posology in human medicine are between 1 milligram and 500 milligrams of product, which can be given in one or more administrations. The compositions are prepared in forms compatible with the route of administration used, such as tablets, sugar-coated pills, capsules, suppositories, solutions or suspensions. These compositions are prepared by known methods and comprise between 1 and 60% by weight of the active ingredient (compound with the general formula I) and 40 to 99% by weight of a suitable pharmaceutical excipient compatible with the active ingredient and the physical form of the composition used. By way of example, the formula of a tablet containing a product of the invention is shown.
Example of formula per tablet:
Example 1	5 mg
Lactose	60 mg
Crystalline cellulose	25 mg
K 90 Povidone	5 mg
Pregetatinised starch	3 mg
Colloidal silicon dioxide	1 mg
Magnesium stearate	1 mg
Total weight per tablet	100 mg
32 WE CLAIM:
1. A sulphonamide derivative with the general formula (I)
A represents a substituent selected from among:
- a heteroaromatic ring of 5 or 6 members containing 1 or 2 heteroatoms selected from among oxygen, nitrogen and sulphur, optionally substituted by 1 or 2 halogen atoms, by a Ci-C4 alkyl radical or by a phenyl radical or a heteroaryl radical with 5 or 6 members containing 1 or 2 atoms of oxygen, nitrogen or sulphur;
a bicyclic heteroaromatic ring containing 1 to 3 heteroatoms selected from among oxygen, nitrogen and sulphur, optionally substituted by 1 or 2 halogen atoms or by a C1-C4 alkyl radical;
Ri represents hydrogen, a C1-C4 alkyl radical or a benzyl radical; n represents 0, 1, 2, 3 or 4; R2 represents -NR4R5 or a group with formula:
R3, R4 y Rs independently represent hydrogen or a C1-C4 alkyl; or one of its physiologically acceptable salts.
2. A compound, as claimed in claim 1, selected from among the following group:
[7] N-[3-(2-dimethylaminoethyl)-1H-indol-5-yl]-5-chloro-3-methylbenzo[b]thiophene-2-
[9] N-[3-(2-dimethylamino-ethyl)-1 H-indol-5-yl]-6-chloroimidazo[2,1 -b]thiazoi-5-
[10] N-[3-(1-methyIpiperidin-4-yl)-1H-indol-5-yl]-5-chloro-3-methylbenzo[b]thiophene-2-
[11 ] N-[3-(1 -methylpiperidin-4-yl)-1 H-indol-5-yl]-5-chloro-3-methylbenzo[b]thiophene-2-
sulphonamide hydrochloride.
[14] N-[3-(1-methylpiperidin-4-yl)-1/-/-indol-5-yl]-5-chlorothiophene-2-sulphonamide.
[16] N-[3-(1 -methylpiperidin-4-yl)-1 H-indol-5-yl]quinoline-8-sulphonamide.
[19] N-[3-(4-methylptperazin-1 -yl)methyl-1 H-indol-5-yl]-5-chloro-3-methylbenzo[b]
thiophene-2-sulphonamide.
[20] N-[3-(2-dimethylaminoethyl)-1/-/-indol-5-yl]-5-(2-pyridil)thiophene-2-sulphonamide.
[21] N-[3-(2-dimethylaminoethyl)-1H-indol-5-yl]-2,1,3- benzothiadiazol-4-sulphonamide.
[27] N-{3-[2-(morpholin-4-yl)ethyl]-1H-indol-5-yl}-5-chloro-3-methylbenzo[b]thiophene-2-
[30] N-[3-dimethylaminomethyl-1H-indol-5-yl]-5-chloro-3-methylbenzo[b]thiophene-2-
[32]N-[3-(2-dipropy!aminoethyl)-1H-indol-5-yll-5-chloro-3-methylbenzo[b]thiophene-2-
[33]N-[3-(2-dibutylaminoethyl)-1H-indo!-5-yl]-5-chloro-3-methylbenzo[b]thiophene-2-
[38] N-[3-(octahydroindolizin-7-yl)-1H-indol-5-yl]-5-chloro-3-methylbenzo[b]thiophene-2-
[39] N-[3-(2-diethylaminoethyl)-1H-indol-5-yl]-6-chloroimidazo[2,1-b]thiazol-5-
[43]N-[3-(3-diethylaminopropyl)-1H-indol-5-yl]-5-chloro-3-methylbenzo[b]thiophene-2-sulphonamide.
[44] N-{3-[2-(pyrrolidin-1-yl)fethyl]-1H-indol-5-yl}-5-chloro-3-methylbenzo[b]thiophene-2-
[50] N-{3-[2-(morpholin-4-yl)ethyl]-1H-indol-5-yl}quinoline-8-sulphonamide.
3. Process for preparing a sulphonamide derivative with the general formula (I), as claimed in claim 1, comprising reacting a compound with the general formula (II), or one of its suitably protected derivatives,
wherein A has the meaning indicated previously in the general formula (I) of claim 1, and
X is a suitable leaving group including an halogen atom, particularly chlorine;
with a 5-aminoindole with the general formula (III), or one of its suitably protected
derivatives;
wherein n, Ri, R2 and R3 have the meanings indicated above in the general formula (I) as claimed in claim 1;
in order to obtain the corresponding sulphonamide, and optionally removing the protective groups from it.
4.	Process for preparing a sulphonamide derivative with the general formula (I), as
claimed in claim 1, wherein Ri, R2, R4, n and A have the meanings indicated above in
claim 1, and R3 represents a d-C4 alkyl, comprising reacting a compound with the
general formula (I), wherein R1f R2, R4, n and A have the meanings indicated above in
claim 1, and R3 represents an atom of hydrogen, with an alkyl halide or dialky! sulphate.
claimed in claim 1, wherein Rtl R3l and A have the meanings indicated above in claim 1,
n=0 and R2 represents a 1,2,3,6-tetrahydropyridin-4-yl radical substituted in position 1 with
an R1 radical, comprising reacting a compound with the general formula (I), wherein R1(
R3l and A have the meanings indicated above in claim 1, n=0 and R2 represents an atom
of hydrogen, with a 4-piperidone substituted in position 1 with an R1 radical.
claimed in claim 1, wherein Ri, R3, and A have the meanings indicated above in claim 1,
n=0 and R2 represents a 4-piperidinyl radical substituted in position 1 with an Ri radical, by
reduction of a compound with the general formula (I) wherein Ri, R3, and A have the
meanings indicated above in claim 1, n=0 and R2 represents a 1,2,3,6-tetrahydropyridin-4-
yl radical substituted in position 1 with an Ri radical.
7.	Process for preparation of physiologically acceptable salts of the compounds with
the general formula (I), as claimed in claim 1, comprising reacting a compound with the
general formula (I) with a mineral acid or an organic acid in a suitable solvent.
8.	Pharmaceutical compositions, comprising, in addition to the pharmaceutically
acceptable excipients, at least one compound with the general formula (I) or one of its
physiologically acceptable salts, as claimed in claims 1 and 2.
9.	Compound as claimed in claim 1 for prevention or treatment of anxiety, depression,
cognitive memory disorders and senile dementia processes and other dementias where a
cognition deficit is predominant, psychosis, infantile hyperkinesia (ADHD, attention deficit /
hyperactivity disorder) and other disorders mediated by the serotonin 5-HT6 receptor in
mammals, such as man.
10. A sulphonamide derivative as claimed in claim 1 for the preparation of a medicament for preventing or treating anxiety, depression, cognitive memory disorders and senile dementia processes and other dementias where a cognition deficit is predominant, psychosis, infantile hyperkinesia (ADHD, attention deficit / hyperactivity disorder) and other disorders mediated by the serotonin 5-HT6 receptor in mammals, such as man.
LABORATORIOS DEL DR. ESTEVE, S.A.
AVDA.MARE DE DEU DE MONTSERRAT, 221, E-08041, BARCELONA, SPAIN
1 MERCE-VIDAL RAMON AVDA.MARE DE DEU DE MONTSERRAT, 221, E-08041, BARCELONA, SPAIN.
2 ANDALUZ-MATARO BLAS AVDA.MARE DE DEU DE MONTSERRAT,221, E-08041,BARCELONA,SPAIN
3 FRIGOLA-CONSTANSA JORDI AVDA.MARE DE DEU DE MONTSERRAT,221, E-08041,BARCELONA,SPAIN
C 07 209/14
PCT/ES02/00518
1 P 200102517 2001-11-14 Spain

redpajama_set_name: RedPajamaCommonCrawl


RIVERSIDE, Calif. – City Manager Al Zelinka has reorganized the executive staff of the City of Riverside to bring an even stronger focus to top priorities and customer service while also cutting $150,000 in costs.
The changes include elevating two department heads – Lea Deesing and Rafael Guzman – to the post of Assistant City Manager and creating two Deputy City Manager positions, which will be filled by Carlie Myers and Moises Lopez. In the process, Zelinka is cutting one Assistant City Manager position, which he held before being named City Manager in late May, and repurposing the position of Intergovernmental Relations Officer previously held by Lopez.
The changes will allow the City Manager's Office to use the same number of people to accomplish more work with a greater level of emphasis on priorities that have been established by Mayor Rusty Bailey and the Riverside City Council through the strategic planning process known as Riverside 2.1. The reorganization will expand the ability of the City Manager's Office to better serve the Mayor, City Council, residents and businesses in Riverside, while reinforcing the organization's performance and financial health.
Deesing previously worked as Riverside's Chief Innovation Officer, overseeing the Innovation and Technology Department. Guzman was the Director of Community and Economic Development. Myers most recently worked as Principal Management Analyst in the City Manager's Office, while Lopez has spent the past three years as Intergovernmental Relations Officer in Riverside.
Zelinka said he promoted Deesing and Guzman because of their unique abilities within the City's 2,400-member workforce. Deesing is very well-regarded in the community for her ability to use technology to modernize operations and provide the public with greater access to information, including through the EngageRiverside.com portal. Guzman is known for streamlining the development process in Riverside to attract and retain investment in the city. Under his leadership, Riverside has created a One Stop Shop that enables business people who want to create jobs in Riverside to get through the entitlement process faster and more efficiently in one location.
The Deputy City Manager positions are new to the current structure of the City Manager's Office, but have been utilized in Riverside in past administrations. These two positions will absorb some of the workload that was being carried by the third Assistant City Manager post, which is being eliminated.
Moving forward, Zelinka will work directly with the Mayor and City Council while providing oversight of the daily administration of the City; Riverside Public Utilities; the Office of Organizational Performance and Auditing; and the Office of Communications.
Deesing will oversee the following departments: Police, Fire, Library, Museum, Innovation and Technology, Finance.
Guzman will supervise: Community and Economic Development; Public Works, Parks, Recreation and Community Services, Human Resources, General Services, and the Community Police Review Commission.
In the Deputy City Manager roles, Myers will be responsible for an expanded approach to Ward Action Teams and a future City Ombudsman program. Lopez will handle intergovernmental relations; and the Office of Homeless Services. His previous position, Intergovernmental Relations Officer, is being repurposed into the Deputy City Manager job.
All Assistant City Managers and Deputy City Managers are responsible for providing assistance to the Mayor and City Council as needed.
Deesing and Guzman each will be paid $241,620. Exact salaries for Myers and Lopez have not been determined because the positions have not been formally approved by the City Council. City Council members have been apprised of the idea, and will be asked to approve the reestablishment of the Deputy City Manager classification on June 19.
Interim directors for the departments previously managed by Deesing and Guzman – Innovation and Technology, and Community and Economic Development – will be named at a later date.


text:
Q: How can I set static asset cache-control headers while using PHP on Heroku? Is this worth trying to accomplish or should I move the assets to CloudFront (or some other CDN)?
Based on past experience, I'm hesitant to go down the CDN route with this project. I tried using a rake task to minify and concatenate my assets, then upload them to the CloudFront. However, when I deployed the project (now containing the rake task) Heroku decided that my app was now ROR and not PHP and the app was toast.

redpajama_set_name: RedPajamaStackExchange


Ricky Schroder is a director as well as an American actor. He is famous for his work in many different TV shows and movies like Too Young the Hero, Call of the Wild, NYPD Blue, Face of Terror, Black Cloud and many others. He has also worked as a director and he has been nominated for and also has won numerous awards in different categories and has made a name for himself.
According to Ricky Schroder bio, He was born as Richard Bartlett Schroder, Jr. in Brooklyn, New York, the U.S.A. on the 13th of April, 1970. Ricky Schroder age is 47 years now. He belongs to mixed European ethnicity. He holds an American nationality. Info about Ricky Schroder family is not available now.
His popularity has been huge as people have been reading and searching about his work, life, and career in different websites like Wikipedia or IMDB, which contain his biography. Likewise, he also has got a huge fan following on his social media sites like Instagram and Twitter. Here they can stay updated on all his recent activities and posts. We can search him on Ricky Schroder Wikipedia also.
industry, Ricky Schroder began out quite young when he was about 10 years old. Since then he has been nonstop active in this sector.
Ricky Schroder has been in the film industry for almost 35 years now. He has acted in numerous movies and shows. With his impressive character portrayal, work rate and good behavior, he has made a lot of admirers, friends, and fans around the world.
He is a good-looking man with blue eyes and blonde hair. Ricky Schroder height is 5 feet and 10 inches. He has a slim and athletic body. Unfortunately, his weight and other measurements are not available anywhere on the internet.
Is Ricky Schroder Married? Who is his Wife?
Regarding the love life of Ricky, he has not had a lot of affairs or relationships in his career. A good-looking man, who had wealth and fame at a very young age; it was not difficult for him to attract women by his charm and personality. An actor, Ricky has always been marked and followed by the paparazzi.
Although in many cases we find rumors and joke news there isn't much in this case. Ricky Schroder has been married for a long time now with his wife Andrea Bernard. Ricky met Andrea Bernard when he was shooting a movie in Canada. After spending a short time, they fell in love with each other. They got married in the September of 1992. They had four kids together. They don't seem like getting a divorce anytime soon.


text:
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Tales from the Dev Side: Redefining Indie Success by Shahed Chowdhuri
July 12, 2012 by Indie Gamer Chick 15 Comments
Back in March, I published what is probably the most optimistic edition of Tales from the Dev Side I have gotten yet. Mr. Shahed Chowdhuri is the developer of Angry Zombie Ninja Cats, a game that I boiled in oil back in November. He's also the creator of the XBLIG Sales Data Analyzer, which has been well received among his peers. He's also one of the most gosh-darned nice guys in the community, and his first editorial on here about gaining community acceptance was cited as being inspirational to newcomers on the Xbox Live Indie Game scene. Now, Mr. Shahed has a different, yet still insanely chirpy and upbeat message to share with everyone: success is what you make of it.
Redefining Indie Success
by Shahed Chowdhuri
"Chowdhuri? Chowdhuri? It's CHOW-DAHuri!"
THE INDIE SCENE
With Indie developers appearing (and disappearing) faster than you can say "game over", there is no shortage of Indie games flooding every corner of the market. From the PC to your favorite smart phone/tablet, from the Xbox 360 to the upcoming PlayStation Mobile games, Indie games are everywhere. There's even talk about a new console named Ouya, which will supposedly offer free-to-play games for your TV. It raised a million bucks on its first day on KickStarter, even as naysayers are pointing out its flaws. For established indie developers, churning out yet another anticipated sequel virtually guarantees millions in the bank. But, for aspiring developers, every new game may mean months of work with no success. Back to Ramen noodles!
But what does success really mean for an Indie developer? Is it a 4-star rating? Or is it thousands in sales? Or is it just breaking even and making a profit?
Instead of answering these questions directly, let me offer two pieces of advice.
Don't let others define your success. Understand what others have to say, and why they're saying it.
Don't try to re-create someone else's success. Follow your own path.
The first point is very important if you want to keep getting motivated to do what you love. The latter is even more important for keeping yourself on track. As a great philosopher once said, "It is better to succeed than to just suck."
It also helps if you dress like a boss.
UNDERSTANDING FEEDBACK AND REACTIONS
Let's say you've just released your first game, and you've learned a lot from your experience. You may not have sold very many copies, but you've learned enough about game programming and the industry to do better next time. If you have dismal ratings and horrid graphics, most gamers will shy away from your game. They may never have the chance to experience your game, even if you feel that the gameplay makes it worth playing. This may discourage many Indie developers from making a second game. However, there is a different way of looking at it: don't simply look at your game as a miserable failure. Learn from your mistakes, and read between the lines of what others have to say. What can you improve in a future update? Does it make sense to build a better sequel? A completely different game, perhaps? You may not have been successful at releasing a hit game, but you were at least successful in completing a game. That is a lot better than many developers who give up before releasing their first game.
FOLLOWING YOUR OWN PATH TO SUCCESS
If you are an Indie game developer, you are most likely a full-time software developer at your day job. Either that, or you have the ability to get a new job as a programmer. Use your game-development experience to bring something useful to the workplace. Get out there and meet other local developers. Attend conferences and join user groups. Build a website and share your work. Spread the word through social channels. The more you exchange information with others, the more you will learn. You will eventually find your niche and start to excel at it. Whether your expertise lies in tap-tap games on iPhone or Minecraft lookalikes on Xbox 360, only you can determine this path.
ONEKSOFT GAMES AND LABS
Reflecting on my own rollercoaster indie experience, I have to mention that I started off with 2 simple games. My first game came about one evening after I read "Learning XNA 4.0", while my second game was built in two weeks, on top of the Platformer Starter Kit. Both games spent weeks in playtesting and peer review before being released. 2D Math Panic remained at 3 stars on Xbox Live Indie Games, while Angry Zombie Ninja Cats did a little better at 3.5 stars after bouncing back and forth between 3 and 4 stars. Both were profitable, since I had no expenses except for my $99 annual fee. But neither game has the looks or the charm to write home about. But what followed was what redefined my success in the world of Indie games.
As you may know, I took my experience from my first two games and put together the XBLIG Sales Data Analyzer (SDA) and the XNA Basic Starter Kit (BS Kit). With a string of media coverage by The Indie Mine, Armless Octopus, VVGTV and of course, Indie Gamer Chick, my tools were promoted and accessed around the world. Even today, Google-searching "xblig sales data" puts my Analyzer in the top search results. Better yet, try searching for simply "sales data analyzer" and my Analyzer dominates the search results
Fortunately, my contributions to the .NET community were recognized at work. I was asked to put together a presentation on XNA for my colleagues, and I have also been working on a prototype for Kinect in the Workplace. Plus, it was a huge bonus to be able to attend Microsoft conferences for free, from the inaugural Security Development Conference in Washington DC in May to the annual TechEd conference in Orlando in June.
Shahed's work on .NET development got him a free trip to Universal Studios, where he met his hero. Immediately after this picture was taken, Wolverine cut his left leg off.
Beyond dev tools, I'm also working on video tutorials (screencasts, if you will) for Indie developers. Going beyond the Xbox 360, I plan to develop games and tools for more Indie developers across more platforms.
KNOW WHEN TO QUIT
Not all projects will turn out the way you want them to. You may even have to put some projects to sleep when their time has run out. Cut your losses, and make the best of what you've completed so far. Corporate behemoths do this all the time, and so can you. Sega discontinued their Dreamcast hardware to focus on their software, when they realized that they couldn't keep up with the competition in the console market. Google Labs (precursor to Google X) killed off projects periodically, if they didn't amount to anything.
In the same line of thinking, I started to build a new game this summer, with the intention of submitting it to Dream.Build.Play and the XNA Last Dance website. It was built on top of my very own Starter Kit, as a complete game which could also serve as a tech demo. But, when I realized that I couldn't finish the game on time, I shelved it temporarily and focused on updating my Starter Kit instead. I had made some improvements to the Kit's core engine while working on the game. So, I uploaded the latest version of my Kit to the OnekSoft Labs site.
Finding your own success is not an easy feat. You may even discover that game development is not for you. Or you may realize that you need some formal education or real-life experience in game development before you can build something on your own. Take a look at top developers like DigitalDNA Games. From "Ask Angela!" to "Avatar Paintball" and the best-selling CastleMiner games, today's success came from years of hard work. Even the Indie Gamer Chick had to start somewhere. From a no-name indie slayer, she has become the "most-read Xbox Live Indie Game critic in the world." Don't worry about trying to impress the critics. Do what you love, and be honest with yourself. If you think you can do better, just do it. Or not. Just make a decision and own that decision. Don't go blaming the competition or the market for your results. Learn to adapt to any market, and you will be successful in your own right.
Filed under Tales from the Dev Side Editorials Tagged with .NET, Game Development, Indie Games, Indie Gaming, Xbox, Xbox Live, XNA, XNA Development
15 Responses to Tales from the Dev Side: Redefining Indie Success by Shahed Chowdhuri
Ivatrix Games says:
OnekSoft Games (@OnekSoftGames) says:
Thanks, Ivatrix! 🙂
Btw, I just realized that the guy in the background looks like he's also attempting to do the Wolverine pose, lol
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Daniel Dobson (@_Eclectus) says:
Well written, and objective 🙂
Thanks, Daniel! 🙂
Dave Voyles (@DaveVoyles) says:
Nice job of putting things in perspective. Often indies start off far too ambitions and either:
1) Never get the game done
2) Release something that they aren't proud of
This offers the middle ground, where you can release something, be proud of it, and learn from the experience.
Yep, my thoughts exactly. 🙂
Scott Tykoski says:
Please tell me you code in that tux 😉
Great read…I find your optimism very inspiring! 🙂
Of course I do, doesn't everyone code in their tux? 😉
Cuddle Bear says:
Very inspiring! It makes me want to start my next game right now. Unfortunately, I promised myself that I would not start my next game until my current project (non-XNA) is done and generating revenue. You made one very good point in this article. My C# skills increased dramatically while making Cuddle Bear. I would not be where I am at work if I had not made this game. And if I am ever in a hiring position, an XNA dev would be at the top of my list. Keep up the great work on your analyzer and I'm looking forward to using your starter kit.
Thanks, Cuddle Bear! Best of luck in your projects!
I am also planning on expanding my dev tools for other platforms, so I'd love to hear about your non-XNA project as well.
Cyber Sleeve (@SuperSmithBros) says:
A well written and upbeat article mate, an excellent read and great for any aspiring Indie Devs out there! =D
CuddleBear says:
I concur. I might just pull an all-nighter tonight with all of this inspiration.
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2021 is truly the year of the Digital Pinball Table, with ANOTHER! The Well Played is supported by Zaccaria and com… twitter.com/i/web/status/1… 11 minutes ago
Now, is Arcooda better than Pinball FX3? To be determined. The @arcade_1up Attack from Mars cabinet has no release… twitter.com/i/web/status/1… 43 minutes ago
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text:
Der Weihertannensee ist ein kleiner Baggersee in Kahl am Main im Landkreis Aschaffenburg in Unterfranken.

Beschreibung
Der Weihertannensee liegt am nördlichen Ortsrand von Kahl am Main, direkt am größeren See Freigericht-Ost. Am westlichen Ufer verläuft die Bundesstraße 8 und dahinter die Landesgrenze zu Hessen. Der gut fünf Hektar große See gehört zur Kahler Seenplatte. Der Weihertannensee entstand im Jahr 1970 durch Kiesabbau. Vor dem Beginn des Kiesabbaus befand sich am heutigen Platz des Sees ein versumpftes Gebiet, in dem Torfstich betrieben wurde. Durch dieses Gebiet verlief der Weihergraben in Richtung Schifflache. Er gehört als Privatbesitz zum nahegelegenen Schloss Emmerichshofen und ist seit 1968 von einer Ferienhauskolonie, in skandinavischem Baustil, komplett umgeben. Es besteht eine Verbindung zum Freigericht-Ostsee.

Siehe auch
 Liste der Seen im Spessart
 Liste der Seen in Bayern

Weblinks

 Lage des Weihertannensees auf dem BayernAtlas

Einzelnachweise

SWeihertannensee
See im Landkreis Aschaffenburg
See im Spessart
Geographie (Kahl am Main)

redpajama_set_name: RedPajamaWikipedia


text:
Excerpt: "Cliff Lee for Jorge Alfaro"
"It's not that Alfaro isn't a good prospect, it's that the path from prospect to championship-caliber player is far more fraught than fans seem to recognize. Alfaro is drawing ridiculous comparisons to Ivan Rodriguez. At 21, Rodriguez was in his third year as the Rangers' starter, so first of all, stop. But let's give Alfaro a path that looks pretty good. Let's say he moves up a level a year and is ready to be the team's starting catcher in 2017, at 24, and that he's actually good -- a two-win player as a rookie, worth three wins at 25, four at 26. That's awfully valuable, especially for a player making the minimum or a bit above in all those years. That would make Alfaro a success story -- nine wins in his first three seasons. Do you know how many catchers have been worth at least nine bWAR in their first four seasons (chosen to account for cups of coffee shorting players a "year") since Deadball II ended? Twenty-one. Once every two years or so, you get a catcher that good. How much better would you like Alfaro to be?"
A Note on Run Scoring
From Wednesday night around 10 p.m.:
"There have been just 45 runs scored today across seven full and five partial games. Record for a 15-game day is 79 (9/12/69), I believe."
By the end of the 7 p.m. starts, there had been just 40 runs scored in nine completed games. Some extra-inning contests would end up pushing up the day's total, but April 16 was still notable: the third-lowest scoring day of games with at least 15 games played. Here's the top five:
We didn't quite set the record Wednesday, but with three of the five lowest having come in the last eight months of baseball, it seems like we could be in for more challenges. A day of baseball in which we average just five runs, total, per game? Just more evidence that strikeouts are clogging the machine.
(h/t Cory Schwartz and MLBAM)
Excerpt: "State of the Game, Pt. 4"
"If you're going to fix the strikeout problem, one that is most prevalent in the late innings, this is where you start. The people who obsess over the pace of the game often make suggestions that target specialization and batter-by-batter baseball -- usually mandating that a pitcher must face multiple batters before he can be removed. That's a half-measure. The simplest, most elegant and most effective way to start fixing the strikeout problem is with one rule change:
"No pitcher can be removed once an inning has begun, absent evidence of an injury or at least six batters faced in the inning. A pitcher removed due to injury must immediately be placed on the 15-day disabled list."
"For all the numbers I've thrown at you this week, we're dealing with something subjective: what should baseball look like? Is there some kind of balance between offense and defense, between pitchers and hitters, between three true outcomes and balls in play, that represents the best kind of ball? For too long, that balance has been expressed in terms of run environment. But as I've pointed out this week, the 4.17 R/G world of 2013 and the 4.12 R/G world of 1992 have nothing in common but the scoreboard. A simplistic reliance on run levels and home-run counts has led to the conclusion that somehow baseball is "normal" again, when what we actually have is the game from 15 years ago with strikeouts pumped up. Power, as measured in just about every way, hasn't changed all that much."
"It is possible, and I'll admit this is rank speculation, that the increased velocity engineered into today's pitchers is breaking the dimensions of baseball. We've always known that hard-throwing pitchers have had an advantage; the ability to miss bats and generate strikeouts, a statistical proxy for velocity prior to the 2000s, was the best predictor of pitcher success and longevity. However, not everyone could be Nolan Ryan, and on balance, the pool of pitchers couldn't throw hard enough to upset the balance of the game. Now, they can."
"Pitchers are dominating the strike zone like they never have before. After the 1968 season, in which MLB pitchers ran a 2.41 strikeout-to-walk ratio and a 16% strikeout rate (on the heels of similar numbers in 1967), the game's powers that be made radical changes to the rules to restore order. Well, MLB pitchers have set records for K/UIBB in every one of the past three seasons, pushing the mark to 2.7 in 2013, with a 20% strikeout rate. Pitchers are dominating hitters today in the same way they were in 1968, with the difference being masked by the power modern hitters generate when they do make contact. Baseball today is basically baseball in 1968 plus weight training and equipment changes."


text:
Reinhard Morgenstern (* 10. März 1942 in Berlin) ist ein deutscher Physiker.

Leben
Morgenstern lebte von 1952 bis 1961 in Bad Berleburg und absolvierte 1961 sein Abitur am dortigen Johannes-Althusius-Gymnasium. Er studierte ab 1962 in Freiburg im Breisgau. Im Jahre 1971 wurde er mit einer Arbeit über "Ionisationsprozesse beim langsamen Stoss schwerer Teilchen" promoviert. Es folgte ein zweijähriger Aufenthalt am Stanford Research Institute in Kalifornien.

Er arbeitete am Hahn-Meitner-Institut in Berlin und an der Katholischen Universität Löwen. Ab 1986 war er Universitätsprofessor am Kernphysikalischen Beschleuniger Institut KVI an der Rijksuniversiteit Groningen. Im Jahre 2006 wurde er zum Offizier des Ordens von Oranien-Nassau ernannt.

Morgenstern ist seit 2009 ehrenamtlich als Ortsvorsteher von Jechtingen-Sasbach tätig.

Weblinks
 Rijksuniversiteit Groningen: 044 - Koninklijke Onderscheiding voor negen RUG-medewerkers, 1. Mai 2006.

Einzelnachweise

Physiker (20. Jahrhundert)
Physiker (21. Jahrhundert)
Kernphysiker
Träger des Ordens von Oranien-Nassau (Offizier)
Teilchenbeschleuniger-Physiker
Korporierter im Wingolf
Deutscher
Geboren 1942
Mann


When it comes to getting bang for your family vacation buck, there's nothing like scoring a free hotel stay or a nice upgrade. But it's all too easy to get obsessed with chasing points and lose sight of whether you are getting good value.
It's important to understand how loyalty programs rope us in and influence our travel decisions. According to Deloitte, roughly 18 percent of frequent travelers become loyal to a given hotel brand primarily because of its rewards program, and some travelers are willing to pay more to stay at a hotel that belongs to his or her loyalty program. In other words, they lose sight of whether they are making smart decisions.
The quest to amass points can sometimes encourage travelers to make poor choices. Always weigh each purchasing decision carefully, and do comparative pricing in order to know whether it's truly worth staying at a hotel chain solely to rack up points.
Don't have time to research which hotel loyalty programs are worth joining? US News & World Report has done the legwork for you. Its annual rankings identify 28 hotel and airline loyalty programs with the most rewarding perks. In its 2017 study, Marriott Rewards topped the list for the Best Hotel Rewards Programs.
Wyndham Rewards allows members to redeem free nights at more than 7,800 hotels. In the past year, Wyndham has debuted new membership tiers and additional benefits, such as early check-in, late checkout, free amenities and suite upgrades. Choice Privileges and Marriott Rewards tie at No. 2 with both programs offering visitors a variety of lodging options and price ranges.
The Marriott Rewards program lets members earn rewards points for stays in 17 affiliated brands, including The Ritz-Carlton, Courtyard Marriott, Renaissance and more. In addition to hotel stays and room upgrades, you can redeem points for spa and dining gift cards, merchandise or for unique experiences, such as concerts and sporting events. Plus, Marriott Rewards points can be used to pay for TSA Precheck applications and flights through more than 40 airline rewards programs like United MileagePlus and Delta SkyMiles.
Wyndham Rewards was the number one program according to CardHub's 2015 Hotel Rewards Study, which examined the rewards programs offered by the 12 largest US hotel chains based on 21 key metrics, including point expiration policies, the presence of blackout dates, brand exclusions, rewards value, and more.
CardHub's report identified the best and worst hotel rewards programs for three different spending profiles: Light ($487 per year), Moderate ($779 per year), and Heavy ($1,461 per year). Collectively, these three groups collectively represent roughly 60 percent of cardholders.
Want to fast forward to find the best loyalty program for your own family? The report also featured a custom calculator that allows you to personalize the results based on your own hotel budget.
Wyndham Rewards was deemed the best hotel loyalty program for travelers of all spending levels, earning an overall CardHub score of 71.85. When looking at all three spending groups, the next best hotel loyalty programs were Drury Gold and La Quinta.
Best Western is the only hotel chain that offers points that do not expire due to account inactivity. All other hotel points expire after 12 to 24 months of inactivity.
Starwood Preferred Guest is the worst hotel rewards program across all three spending groups followed by the Ritz-Carlton, according to CardHub's study.
None of the hotel rewards programs allows members to earn points on reservations booked through third-party websites, such as Kayak.com, Hipmunk.com, or Expedia.com.
One-third of hotel programs do not allow users to redeem points for award nights at all hotel brands and properties.
Buying points is a generally a bad deal, forcing program members to pay 19 percent more than their points are worth on average. Consumers who do not have enough points to book a room are better off using the "points and cash" option offered by all chains.
US News & World Report's travel rankings are based on an analysis of expert and user opinions for a mix of opinion and data, in an effort to make rankings more useful than simply providing editors' personal opinions.
CardHub compared the loyalty rewards programs based on number of properties, using publicly available information and company policies posted online. To score each program, most of the metrics were first graded on a 100-point scale. Generally, full points were awarded to the best-performing program for that metric, while the zero-point level was set slightly below the worst program's result. Find more details here.


The Wake Forest Center for Retail Innovation provides resources for faculty and student-led academic and practitioner-oriented learning to help drive the future of retail. The Center arranges unparalleled educational opportunities through engagement and collaboration with industry partners, enabling students to have impact through an ability to think strategically, act practically and communicate effectively. Learn more about the Center's vision and mission.
Hear from some of the Center's faculty and students as they share what makes retail an inspiring and innovative industry to work in. This video is part of the National Retail Federation's "This is Retail" campaign, which also involves the North Carolina Retail Merchants Association.


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Q: How to check if my html will print longer than one page? I was wondering if there was a way using php or javascript to see if my webpage will be longer than one page when printed. I have specific elements that need to be at the bottom of the page regardless of how long the content in the middle of the page is, (max one page including footer).
Tried various css elements such as bottom.

A: Have you tried making a separate 'print.css' file that only alters the way a page looks when it is going to be printed? <link rel="stylesheet" type="text/css" href="print.css" media="print">. This can also be done with an @media print { } tag in your regular css file.


All parents make mistakes at some point or another but many of them seem to happen in during baby's first year. Below is a list of tips which will hopefully help you to avoid making them.
Spending the first year of your child's life panicking over everything and anything from vomiting to the frequency of your little angels bowel movements is nether productive or healthy and baby will pick up on that anxiety. Psychoanalyst Dr Leon Hoffman has said this level of worry will only get in the way of enjoying your infant's first year of life. "Babies are far more resilient than we give them credit for."He said.
Unfortunately, parents are hardwired to do everything within their power to prevent distress in their children. Whats also unfortunate is that babies cry…a lot and this is not because we have done something wrong and need to fix it but because it is natural and part of being a baby. However, with that said if your baby is inconsolable for an hour and crying is associated with fever, rash or persistent vomiting, seek medical advice.
Many parents get confused and concerned about the temperate of their newborn. Any temperature of over 38C in a baby under three months (or over 39°C in a child three months or older) is considered serious and medical advice should be sought.
Oral hygiene is not something we naturally associate with newborn babies, but its never early to start encouraging good habits. Try not to give your baby milk in bed once teeth have started appearing as this will increase the risk of cavities developing which is known as 'baby bottle decay'. Another good tip is to wipe down your baby's gums with a wet cloth and start using a tooth brush as soon as the first teeth start developing.
Your new baby will all of a sudden become your first priority with everything else falling at the wayside. However, it's really important that we work at keeping the relationship with our partners strong as a having a child will magnify any weaknesses in the relationship. Make sure you are still making time for yourselves as a couple and never feel selfish for doing so because your child will grow all the more stronger from having a close family as their foundation.


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Karl Groß (* 27. Dezember 1934; † 12. Juli 2019) war ein deutscher Fußballspieler. Er spielte von 1957 bis 1960 für den SC Wismut Karl-Marx-Stadt 29-mal in der der DDR-Oberliga, der höchsten Spielklasse im DDR-Fußball. 1957 und 1959 wurde er mit dem SC Wismut DDR-Meister.

Sportliche Laufbahn
Am 15. Dezember 1957, im letzten Saison-Punktspiel (es wurde im Kalenderjahr-Rhythmus gespielt) des SC Wismut Karl-Marx-Stadt, kam Karl Groß in der 60. Minute als Einwechselspieler zu seinem ersten Oberligaeinsatz. Zusammen mit seiner Mannschaft konnte er den Gewinn der Meisterschaft feiern. In der folgenden Saison spielte Groß vom ersten Punktspieltag an und wurde mit 22 von 26 ausgetragenen Oberligaspielen als rechter Verteidiger Stammspieler des SC Wismut. Von den acht Spielen im Europapokal der Landesmeister 1958/59 bestritt er nur die ersten drei Partien. Als sich der SC Wismut 1959 seine zweite Fußball-Meisterschaft holte, hatte Groß mit nur vier Oberligaspieleinsätzen wieder nur einen marginalen Anteil am Titelgewinn. In der Saison 1960 verringerten sich seine Oberligaeinsätze auf zwei Spiele. Bis 1963 wurde er noch in der Oberliga-Reserve eingesetzt, wo er weiterhin als Abwehrspieler eingesetzt, einen Stammplatz innehatte.

Nach seiner aktiven Laufbahn engagierte sich Groß als Jugendtrainer in Aue.

Literatur
 Deutsches Sportecho: Jahrgänge 1957–1960.
 Hanns Leske: Enzyklopädie des DDR-Fußballs. Verlag Die Werkstatt, Göttingen 2007, ISBN 978-3-89533-556-3, S. 172.
 Andreas Baingo, Michael Horn: Die Geschichte der DDR-Oberliga. Verlag Die Werkstatt, Göttingen 2004, ISBN 3-89533-428-6, S. 290.

Weblinks

 Statistik bei bsg-wismut-aue.de

Einzelnachweise

Fußballspieler (DDR)
DDR-Meister (Fußball)
Deutscher
DDR-Bürger
Geboren 1934
Gestorben 2019
Mann


Keep warm this winter with these gorgeous nappa leather gloves new to the Pierotucci collection. Elasticated at the wrist they will feel cozy and snug and keep your hands warm as toast. The delicate design of the ruching creates a very feminine frill at the bottom of the glove. Exquisitely soft Italian nappa lambskin is almost sensual to the touch and wearing these will definitely make you feel special.


ROCKLAND COUNTY, N.Y. -- More than 100 people turned out Tuesday to watch as Lt. Raymond McCullagh became the 11th Clarkstown Police Chief during a swearing-in ceremony at Town Hall.
McCullagh, a lifetime Clarkstown resident, was selected in a 3-0-2 vote by the Clarkstown Town Board over two higher-ranking candidates who were vying for the position.
"Having worked his way up from patrol, Ray is a cop's cop. I am proud to put him forward as our next Chief of Police and I am confident he will make one of the greatest Police Department's in our country even better," said Supervisor George Hoehmann.
He takes over following the firing two weeks ago of former Chief Michael Sullivan by the Town Board. Sullivan is running against Hoehmann this fall for the Supervisor position.
McCullagh was selected from a list of qualified law enforcement professionals provided by Rockland County that included Capt. Robert Mahon, who has led the department since Sullivan's suspension in 2016, and Capt. Anthony Ovchinnikoff.
A graduate of Clarkstown schools, McCullagh received a bachelor's degree from LaSalle University in Philadelphia. He attended the FBI National Academy and has received numerous awards and recognitions throughout his career.


Sake has over 1,000 years of history, and it is produced by the unique process passed down from early times. The following three aspects are the characteristics of sake brewing.
Since Asia has a monsoonal climate with high-temperatures and humidity, koji is used for saccharification, unlike the western culture which uses malt. Koji is a mold grown in grain. In Japan, granular koji, which is purely grown in rice, is uniquely used.
Rice koji and steamed rice are added to the main fermentation mash in three steps, because saccharification and fermentation gradually progress in open systems to prevent the entry of unwanted bacteria. The unique three steps of addition allow sake to have an original aroma and create an unusually high alcohol content of over 20%, compared to other fermented beverages of the world.
"The song for sake brewing" has been passed down and sung by Toji, the master brewers. Many of the steps in brewing took place at odd hours of the day and night. The sake brewers continuously sung in unison to endure the hard work and to concentrate on producing steps correctly. "Sake is alive and does not wait for us." "The song for sake brewing" expresses the good old tradition that the people struggle with nature. A lesson that people at present day tend to forget.
The set temperatures that are suitable for drinking sake have unique expressions in the Japanese language. All of them are expressions of delicate care by Japanese people. Sake can be enjoyed at any preferred temperature.
the subtle taste and pleasurable aroma.
Glass tokkuri can be cooled in a glass or ceramic bowl with ice to prevent it from becoming tepid. Chilling accelerates the coolness of Ginjo-shu and Nama-zake. The types of sake suitable to be served chilled tend to be in stylish bottles or 720ml bottles. Those bottles of sake can be chilled with ice in a wooden bucket. However, please bear in mind that the certain type of sake, such as Ginjo-shu, may lose its flavor if it is overcooled.
This is the way to drink sake without heating or chilling. It is not always the same as room temperature, but sake may be cooled in summer and slightly warmed in winter. This way of drinking can maximize the taste of sake. The type of sake which is suitable to drink at room temperature has excellent taste and balance and maintains the original taste of sake. That is why sake lovers appreciate this style of sake.
your body both in summer and winter.
TThe temperature of heated sake is widely ranges from 30 centigrade to over 55 centigrade. It is natural and suitable for the body to drink heated sake which suffers from summer heat in summer as well as in the cold season. Heating enriches sake's original taste. Serving sake at body temperature leads you to get tipsy faster because your body absorbs sake faster. So, it leads you to drink the appropriate amount of sake. If you taste heated sake little by little in your favorite cup, it provides you with relaxation.
Sake should be stored in a dark place.
As direct ultraviolet sunlight is not good for the skin, it not good for sake either. Other kinds of lights, such as fluorescent light, are also not good for sake. Sake should be stored in a dark place where it can be protected from light as much possible.
Sake should be stored in a cool place.
We tend to upset our health at the change of seasons when there are big temperature differences between day and night. Since sake does not do well with temperature changes, it should not be stored in a place with high temperatures or big temperature differences.
It is essential to manage stock with the date of delivery, and to follow a first-in first-out order to preserve freshness.
It is best to finish up the bottle soon after it is opened.
After opening a bottle of sake, it is recommended to finish at the earliest possible time. This is because once sake is opened it begins to gradually be damaged due to various bacteria. Once a bottle is opened, it should be properly sealed and stored in a cool and dark place. Finish the bottle as soon as possible after opening.


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Sir George Grove, född 13 augusti 1820, död 28 maj 1900, var en engelsk musikolog, vars namn odödliggjorts genom titeln på Grove Dictionary of Music and Musicians.

Biografi
Grove föddes i Clapham och studerade först till civilingenjör och arbetade i två år i en fabrik nära Glasgow. Han var släkt med Edith M. Bratt som var gift med J.R.R. Tolkien. Mellan 1841 och 1845 arbetade han i Västindien och monterade fyrar i Jamaica och Bermuda. 1849 blev han sekreterare i Society of Arts och 1852 i Kristallpalatset. I dessa befattningar fick han utlopp för sitt intresse och entusiasm för musik och han lade all möda och inflytande på att marknadsföra den bästa musiken av alla slag vid de regelbundna konserterna i Sydenham dit Kristallpalatsets flyttats efter den stora världsutställningen i Hyde Park 1851. Konsertserierna var en väl inarbetad tradition under ledning av dirigenten August Manns.

Utan Grove skulle Manns inte ha lyckats uppmuntra unga tonsättare och ge den brittiska publiken musikundervisning. Den analys av Beethovens symfonier som Grove gjorde, och presenterade vid konserterna, kom att bli standard för hur detta skulle göras. Det var som ett resultat av detta, och det faktum att han också var redaktör på tidningen Macmillan's Magazine mellan 1868 och 1883, som idén till det berömda Dictionary of Music and Musicians, publicerat 1878–1880, växte fram och förverkligades. Hans egna artiklar om Beethoven Mendelssohn och Schubert är monument över ett särskilt slags kunskap, även om resten av boken är ojämn.

Långt tidigare hade Grove bidragit till Dictionary of the Bible och hade också stött grundandet av Palestine Exploration Fund, ett sällskap bildat av bibliska arkeologer och präster. Vid en resa till Wien i sällskap med sin vän Sir Arthur Sullivan, fann de ett stort antal okända verk av Schubert, bland annat musiken till Rosamunda. När Royal College of Music grundades 1882 blev han dess förste chef och upphöjd till riddare. Han byggde upp den nya institutionen i nivå med övriga europeiska konservatorier. När de nya byggnaderna invigts 1894 avgick han som chef, men fortsatte sitt engagemang för skolan under hela sitt liv. Han dog i Sydenham och ligger begravd på Brockley and Ladywell Cemeteries.

Referenser
Fotnoter

Webbkällor
 C.L. Graves and Percy M. Young. "Grove, Sir George." I Grove Music Online. Oxford Music Online. (Läst 12 september 2009. Inloggning krävs.)

Vidare läsning

Externa länkar

 Groves lexikon, A Dictionary of Music and Musicians, komplett version inskannad på Wikimedia Commons.

Brittiska musikförläggare
Brittiska musikologer
Personer i Storbritannien under 1800-talet
Födda 1820
Avlidna 1900
Män


On the streeets of the slums one can find many a weapon that was self-made by self-proclaimed gunsmiths, weapons' amateurs or just men in dire need. More often than not such firearm consists of parts that come from various produced models complemented with random elements of everyday items. It is just to be expected that home workshops aren't mach for professional factories therefore those guns tends to show many defects and flaws.


text:
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All we ever wanted : a novel
Giffin, Emily, author.
Publisher, Date:
New York : Ballantine Books, [2018]
"Nina Browning is living the good life after marrying into Nashville's elite. Her husband's tech business is booming, and her adored son, Finch, is bound for Princeton. Tom Volpe is a single dad working multiple jobs. His adored daughter, Lyla, attends Nashville's most prestigious private school on a scholarship. But amid the wealth and privilege, Lyla doesn't always fit in. Then one devastating photo changes everything. Finch snaps a picture of Lyla passed out at a party, adds a provocative caption, and sends it to a few friends. The photo spreads like wildfire, and before long, an already divided community is buzzing with scandal and assigning blame. In the middle of it all, Nina finds herself relating more to Tom's reaction than her own husband's--and facing an impossible choice"-- Provided by publisher.
Married women -- Fiction.
Single fathers -- Fiction.
Teenagers -- Fiction.
Scandals -- Fiction.
Sexting -- Fiction.
Social conflict -- Fiction.
Nashville (Tenn.) -- Fiction.
Domestic fiction.
Novels.
Please select and request a specific volume by clicking one of the icons in the 'Find It' section below.
Suggestions and more
First Chapter or Excerpt
chapter one NINA It started out as a typical Saturday night. And by typical, I don't mean normal in any mainstream American way. There was no grilling out with the neighbors or going to the movies or doing any of the things I did as a kid. It was simply typical for what we'd become since Kirk sold his software company, and we went from comfortable to wealthy. Very wealthy. Obscene was the description my childhood best friend Julie once used--not about us, but about Melanie, another friend--after Melanie bought herself a diamond Rolex for Mother's Day and then offhandedly remarked at one of our dinner parties that homemade pottery from her kids "wasn't going to cut it." "She could feed a Syrian refugee camp for an entire year with that watch," Julie had groused in my kitchen after the other guests had departed. "It's obscene." I'd nodded noncommittally, hiding my own Cartier under the edge of our marble island, as I silently reassured myself with all the ways my watch, and therefore my life, were different from Melanie's. For one, I didn't buy the watch for myself on a whim; Kirk gave it to me for our fifteenth anniversary. For another, I had always loved when our son, Finch, made me presents and cards in his younger years, and was sad that those had become relics of the past. Most important, I don't think I ever flaunted our wealth. If anything, it embarrassed me. As a result, Julie didn't hold our money against me. She didn't know our exact worth but had a general sense of it, especially after she'd gone house hunting with me when Kirk was too busy, helping me find our home on Belle Meade Boulevard, where we now lived. She and her husband and girls were regular guests at our lake house and our home on Nantucket, just as she happily inherited my gently used designer hand-me-downs. Occasionally Julie would call Kirk out, though, not for being showy like Melanie but for having elitist tendencies. A fourth-generation silver-spoon Nashvillian, my husband grew up ensconced in a private-school, country-club world, so he'd had some practice at being a snob, even back when his money was merely old, and not yet obscene. In other words, Kirk came from a "good family"--that elusive term that nobody ever came out and defined, yet we all knew was code for having old money and a certain well-bred, refined taste. As in: he's a Browning. My maiden name, Silver, held no such status, not even by the standards of Bristol, the town on the Tennessee-Virginia border where I grew up and Julie still lived. We were no slouches--my dad wrote for the Bristol Herald Courier and my mom was a fourth-grade teacher--but we were squarely middle class, and our idea of living large was everyone ordering dessert at a nonchain restaurant. Looking back, I wonder if that may have explained my mom's preoccupation with money. It wasn't that she was impressed with it, but she could always tell you who had it and who did not, who was cheap and who was living beyond their means. Then again, my mom could pretty much tell you anything about anyone in Bristol. She wasn't a gossip--at least not a mean-spirited one--she was simply fascinated by other people's business, from their wealth and health to their politics and religion. Incidentally, my dad is Jewish and my mother Methodist. Live and let live is their mantra, an outlook that was passed on to both my brother, Max, and me, the two of us embracing the more attractive elements of each religion, like Santa Claus and Seders, while punting Jewish guilt and Christian judgment. This was a good thing, especially for Max, who came out during college. My parents didn't miss a beat. If anything, they seemed more uncomfortable with Kirk's money than with my brother's sexuality, at least when we first began to date. My mother had insisted that she was just sad I wouldn't be getting back together with Teddy, my high school boyfriend, whom she adored, but I sometimes sensed a slight inferiority complex, and her worry that the Brownings were somehow looking down on me and my family. To be fair, a half-Jewish girl from Bristol with a gay brother and no trust fund probably wasn't their first choice for their only child. Hell, I probably wasn't Kirk's first choice on paper, either. But what can I say? He picked me anyway. I'd always told myself that he fell in love with my personality--with me--the same way I fell in love with him. But in the past couple of years I had begun to wonder about both of us, and what had brought us together in college. I had to admit that when discussing our relationship, Kirk often referenced my looks. He always had. So I'd be naïve to think that my appearance had nothing to do with why we were together--just as I knew, deep down, that the patina and security of a "good family" had, in part, attracted me to him. I hated everything about that admission, but it was definitely on my mind that Saturday night as Kirk and I took an Uber to the Hermitage Hotel for about our fifth gala of the year. We had become that couple, I remember thinking in the back of that black Lincoln Town Car--the husband and wife in an Armani tux and a Dior gown who were barely speaking. Something was off in our relationship. Was it the money? Had Kirk become too obsessed with it? Had I somehow lost myself as Finch grew older and I spent less time mothering him and more time in the role of full-time philanthropist? I thought about one of my dad's recent remarks, asking why my friends and I didn't just skip the galas--and give all the money to charity. My mom had chimed in that we might be able to accomplish "more meaningful work in blue jeans than black tie." I had gotten defensive, reminding them that I did that sort of hands-on work, too, such as the hours I spent every month answering calls on Nashville's suicide helpline. Of course I hadn't admitted to my parents that Kirk sometimes minimized that kind of volunteering, insisting that I was better off "just writing the check." In his mind, a donation of dollars always trumped time; the fact that it came with more splash and credit was beside the point. Kirk was a good man, I told myself now, as I watched him take a swallow of the bourbon roadie that he'd poured into a red Solo cup. I was being too hard on him. On both of us. "You look fabulous," he suddenly said, looking over at me, softening me further. "That dress is incredible." "Thanks, honey," I said in a low voice. "I can't wait to take it off you," he whispered, so the driver wouldn't hear him. He gave me a seductive look, then took another drink. I smiled, thinking that it had been a while, and resisted the urge to tell him that he might want to slow down on the booze. Kirk didn't have a drinking problem, but it was a rare night that he didn't at least catch a red-wine buzz. Maybe that was it, I thought. We definitely both needed to ease up on our social calendars. Be less distracted. More present. Maybe that would come when Finch went to college in the fall. "So. Who have you told? About Princeton?" he asked, clearly thinking about Finch, too, and the acceptance letter he'd just received the day before. "Other than family, only Julie and Melanie," I said. "What about you?" "Just the guys in my foursome today," he said, rattling off the names of his usual golf buddies. "I didn't want to brag . . . but I couldn't help myself." His expression mirrored the way I felt--a mix of pride and disbelief. Finch was a good student, and had gotten into Vanderbilt and Virginia earlier that winter. But Princeton had been a long shot, and his admittance felt like a culmination and validation of so many parenting decisions, beginning with applying Finch to Windsor Academy, the most rigorous and prestigious private school in Nashville, when he was only five years old. Since then, we had always prioritized our son's education, hiring private tutors when needed, exposing him to the arts, and taking him to virtually every corner of the globe. Over the past three summers, we had sent him on a service trip to Ecuador, to a cycling camp in France, and on a marine biology course in the Galápagos Islands. I recognized, of course, that we were at a distinct financial advantage over so many other applicants, and something about that (especially the check we'd written to Princeton's endowment) made me feel a little guilty. But I told myself that money alone couldn't gain a kid admission to the Ivy League. Finch had worked hard, and I was so proud of him. Focus on that, I told myself. Focus on the positive. Kirk was looking at his phone again, so I pulled mine out, too, checking Instagram. Finch's girlfriend, Polly, had just posted a photo of the two of them, the caption reading: We're both Tigers, y'all! Clemson and Princeton, here we come! I showed the picture to Kirk, then read aloud some of the congratulatory comments from children of our friends who would be in attendance tonight. "Poor Polly," Kirk said. "They won't last a semester." I wasn't sure if he meant the distance between South Carolina and New Jersey or the mere reality of young love, but I murmured my agreement, trying not to think of the condom wrapper that I'd recently found under Finch's bed. The discovery was far from a surprise, but it still made me sad, thinking of how much he had grown up and changed. He used to be such a little chatterbox, a precocious only child regaling me with every detail of his day. There was nothing I hadn't known about him, nothing he wouldn't have shared. But with puberty came an onset of remoteness that never really cleared, and in recent months, we'd talked very little, no matter how hard I tried to break down his barriers. Kirk insisted it was normal, all part of a boy's preparation to leave the nest. You worry too much, he always told me. I put my phone back in my bag, sighed, and said, "Are you ready for tonight?" "Ready for what?" he asked, draining his bourbon as we turned onto Sixth Avenue. "Our speech?" I said, meaning his speech, though I would be standing beside him, offering him moral support. Kirk gave me a blank stare. "Speech? Remind me? Which gala is this, again?" "I hope you're kidding?" "It's hard to keep them all straight--" I sighed and said, "The Hope Gala, honey." "And we are hoping for what, exactly?" he asked with a smirk. "Suicide awareness and prevention," I said. "We're being honored, remember?" "For what?" he asked, now starting to annoy me. "The work we did bringing mental health experts to Nashville," I said, even though we both knew it had much more to do with the fifty-thousand-dollar donation we'd given after a freshman at Windsor took her life last summer. It was too horrible for me to process, even all these months later. "I'm kidding," Kirk said, as he reached out to pat my leg. "I'm ready." I nodded, thinking that Kirk was always ready. Always on. The most confident, competent man I'd ever known. A moment later, we pulled up to the hotel. A handsome young valet swung open my door, issuing a brisk welcome. "Will you be checking in tonight, madame?" he asked. I told him no, we were here for the gala. He nodded, offering me his hand, as I gathered the folds of my black lace gown and stepped onto the sidewalk. Ahead of me, I saw Melanie chatting amid a cluster of friends and acquaintances. The usual crowd. She rushed toward me, giving me air kisses and compliments. "You look amazing, too. Are those new?" I reached up to her face, my fingertips grazing the most gorgeous chandelier diamond earrings. "Newly acquired but vintage," she said. "Latest apology from you know who." I smiled and glanced around for her husband. "Where is Todd, anyway?" Excerpted from All We Ever Wanted by Emily Giffin All rights reserved by the original copyright owners. Excerpts are provided for display purposes only and may not be reproduced, reprinted or distributed without the written permission of the publisher.
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Giffin's stellar latest (following First Comes Love), set in Nashville, concerns the wealthy Brownings and the scandal that ensues when their Princeton-bound son Finch appears to have taken a racy photo of Lyla Volpe, a high school sophomore on scholarship at the prestigious Windsor Academy. Nina's husband Kirk grew up with money, and they're richer than ever now that he's sold his tech company. Though he's confident and charming, Nina's starting to question his character-especially when Kirk doesn't want high school senior Finch to face the consequences of the photo of Lyla unconscious and exposed at a party. Though it's not revealed until later in the book who took the photo, it gets widely spread around, and the fallout is substantial. Nina wants Finch to be a good person above all, and she bristles when she learns that Kirk tried to bribe Lyla's father, Tom, to drop the issue with the school. Nina tries to right things with Tom, a carpenter who also drives an Uber to make extra cash. Tom has a huge chip on his shoulder that's exacerbated by the stresses of single parenthood, but he finds himself liking Nina despite her wealth. Meanwhile, Finch starts dating Lyla and tells her that he's covering for the person who really took the photo. Things come to a head as Nina attempts to find out whether her son is honorable or as untrustworthy as his father. Giffin's plot touches on social class and misogyny while delivering an excellent page-turning story. This satisfying novel will appeal to readers looking for a nuanced, thoughtful take on family and social dynamics. (June) © Copyright PWxyz, LLC. All rights reserved.
NEW YORK TIMES BESTSELLER - In this riveting novel from the #1 bestselling author of Something Borrowed and First Comes Love, three very different people must choose between their families and their most deeply held values. . . .
 "An unpredictable page-turner that unfolds in the voices of three superbly distinct characters."-- The Atlanta Journal-Constitution - "A gripping, thought-provoking journey."--Jodi Picoult
 NAMED ONE OF THE BEST BOOKS OF THE YEAR BY THESKIMM

 Nina Browning is living the good life after marrying into Nashville's elite. More recently, her husband made a fortune selling his tech business, and their adored son has been accepted to Princeton.
Yet sometimes the middle-class small-town girl in Nina wonders if she's strayed from the person she once was.
 Tom Volpe is a single dad working multiple jobs while struggling to raise his headstrong daughter, Lyla. His road has been lonely, long, and hard, but he finally starts to relax after Lyla earns a scholarship to Windsor Academy, Nashville's most prestigious private school.
 Amid so much wealth and privilege, Lyla doesn't always fit in--and her overprotective father doesn't help--but in most ways, she's a typical teenaged girl, happy and thriving.
 Then, one photograph, snapped in a drunken moment at a party, changes everything. As the image spreads like wildfire, the Windsor community is instantly polarized, buzzing with controversy and assigning blame.
 At the heart of the lies and scandal, Tom, Nina, and Lyla are forced together--all questioning their closest relationships, asking themselves who they really are, and searching for the courage to live a life of true meaning.
 Praise for All We Ever Wanted
"Page-turning . . . Timely and thought-provoking, it's Giffin's best yet." -- People
 "Giffin's novel has style and substance . . . . Truly excellent." -- The Washington Post
 "If you're looking for a book club selection, All We Ever Wanted is bound to spark meaningful and meaty discussions." -- The Augusta Chronicle
"A page-turning exploration of wealth and privilege." -- Entertainment Weekly
Librarian's View
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Being at one with nature is truly one of the most serene experiences one can have. There is a certain degree of beauty in the simplicity these places offer which ultimately feels like the greatest beauty that there is. Here are five of the most peaceful holiday destinations where being at one with nature comes naturally.
Even though the Caribbean nation of Cuba is mostly famous for its capital city of Havana, which is beautiful in its own way, it is south of the city in a small community called Las Terrazas where Cuban nature can truly be appreciated. Covering over 5,000 hectors of afforested land planted, this biosphere reserve is the embodiment of finding peace in nature. A holiday in Cuba has so much to offer, you can really make it your own. If you enjoy diving and snorkeling, then the renowned Bay of Pigs is the ideal spot with plenty of sunken cenotes resplendent with exotic species of tropical fish.
What makes the nature experience in Cuba so fulfilling is the availability of vegan dishes made from wholesome grains, beans, and vegetables cultivated without the use of detrimental chemicals. A session along the beach or inside the rainforest, feasting on enigmatic root vegetables and sipping fresh coconut water is as good as it gets.
Rwanda is home to three beautiful national parks, each offering exclusive and diverse species of wildlife and plants. The Nyungwe Forest National Park in South Rwanda hosts 13 highly rare primate species. Leopards, striped jackals, golden cats, and the great African civet are all very common in Rwanda. The forests of Rwanda are some of the most ancient Afro-Montane forests in the world with their roots dating back to the Ice Age. Rwanda may be small in size but the natural experience it offers is tremendous.
Peru's humungous swath of Amazon rainforests is not only special, diverse and exceptionally satisfying to visit – Peru's finest Amazon reserves also offer several species of endemic and endangered fauna and flora to explore. The Manu Biosphere Reserve, for instance, is widely termed the 'mecca' for nature-lovers, since enjoying a nice safari with exotic species of wildlife free to roam in and around the park's borders can't really be topped. Some tourists have even had greetings from wild animals outside their eco-lodge cabin doors early in the morning.
For a more eventful experience Pacaya-Samiria, the flooded segment of the Peruvian Amazon offers peaceful boat trips, fascinating and quiet sessions of paddle boarding. If you are looking to go on a spiritual journey, then you could even go on an ayahuasca retreat where you can spend time reflecting on life and meditating. Peru really is the perfect place to be for people looking to immerse themselves in Mother Nature.
The Scottish Highlands offer some of the best natural experiences in Europe. With a population of less than 230,000 people, the sense of loneliness in this place is blissful and best enjoyed in the beautiful mountain tops and clear lakes. The coastal areas are also beautiful, you can stay in some charming little fishing towns, and enjoy exploring the local areas and looking out at the boats bobbing and the seagulls soaring. A great destination for this is Oban, in western Scotland which is very pretty.
Burgenland in Austria is blessed with over 300 days of warm sunshine in a year, making it a must-visit for people who just want to sit back and enjoy the natural beauty of the Lake Neusiedl region. Enjoying the fresh vegetables from the local produce market and cycling through these beautiful roads up to Vienna – pure bliss!
All of these trips offer something different and are must-visits for people who wish to enjoy nature in every way possible.
WHAT IS YOUR FAVORITE OUTDOOR DESTINATION?