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Career profile: Head of Medicine Design – Charlotte Allerton
Charlotte Allerton | Tue, 06/25/2019 - 11:47
Early on in my life, the transformative impact anti-histamine and asthma medicines had on my life awakened a deep curiosity in how medicines work. Eventually I found myself working on teams attempting to design those medicines, most recently within Pfizer's Medicine Design organization.
Discovering and inventing medicines to transform patients' lives is our group's mission, and we aim for this across disease areas such as Oncology, Inflammation and Immunology, Rare Diseases and Internal Medicine (cardiovascular and metabolic diseases, Non-Alcoholic SteatoHepatitis (NASH) etc..). To do this well, many scientists from different disciplines come together to design small molecule compounds with carefully balanced physiochemical and structural properties to ensure they bind to and modulate the biological target selected, can be dosed effectively to reach the required target and survive in the body long enough to have the desired efficacious effect …and do all of this safely (figure 1). Being able to apply our scientific disciplines, as described above, to identify new medicines is such an exciting opportunity – utilizing the science we love to make a difference to patients around the world.
Figure 1: Charlotte Allerton emphasizes that most inventions and breakthroughs come from working in diverse teams of colleagues. Here she is discussing project progress with a colleague in the Pfizer laboratories in Groton, CT.
Describe your present position:
I am fortunate enough to lead the Medicine Design organization in Pfizer. Medicine Design includes three primary focus areas:
Medicinal Chemistry, where colleagues across many branches of chemistry (synthetic chemistry, design chemistry, computational chemistry, chemical biology, analytical chemistry etc) come together to identify new chemical matter on which to start drug discovery projects, and then optimize those molecules into potential drug candidates. This involves using approaches such as structure based drug design to identify the optimal ligand for the target protein, while also building in good oral drug properties and synthetic methodology to underpin an expedited path to clinical testing. For example, our team used a novel approach to design for a lung cancer treatment that crosses the blood-brain barrier, while also addressing some of the resistance mutations that can occur in cancer treatment. This is now an approved drug, Lorbrena, which provides a treatment option to some patients with non-small cell lung cancer.
Pharmacokinetics, Dynamics and Metabolism (PDM) where scientists work to determine the Absorption, Distribution, Metabolism and Elimination (AMDE) profiles of drug molecules, in order to understand "what the body does to the drug", alongside understanding the pharmacology of the drug which dictates "what the drug does to the body". This includes incorporating an understanding of these processes into the design of potential drug molecules as well as describing these characteristics of drug molecules to the regulators during clinical development, to help underpin a drug approval. For example, in designing a potential treatment for the metabolic disease NASH, Pfizer scientists learned that by targeting the liver directly, they could avoid toxicity issues that were seen with systemic dosing.
Discovery Sciences, which encompasses many of the scientific disciplines that underpin the design of small molecule medicines, such as structural biology, to better understand target protein structures in an effort to enable the efficient design of small molecules to bind to the targets, as well as early primary pharmacology and hit identification screening technologies to form predicted "patient relevant" screen sequences that may assist as a guide for drug design.
We work together across all of these areas, with our disease area experts in biology and clinical, to identify new potential medicines and advance them into clinical trials.
Did you get to your present position because of your background in chemistry and area of specialization or did life experience(s) take you there?
My first position within Pfizer was as a synthetic chemist within Medicinal Chemistry working on high throughput synthesis, a technique we use to make large numbers of diverse compounds to expedite the identification of lead compounds, which often form the starting point for further optimization in early discovery programs. So – having a background in chemistry was certainly important in being offered my first job, but it was the continued growth of my chemistry expertise, as well as drug discovery and development knowledge through exposure to projects and through working with very experienced colleagues that kept me hooked on learning more.
After being involved in a number of drug discovery programs, I became fascinated by the relationship between the physiochemical properties of molecules, and how they interact with drug targets and distribute in the human body. The lipophilicity of molecules is one such important property which has to be carefully balanced in drug design. If it is too high, then the molecule may be insoluble or highly metabolized by the liver which is generally not commensurate with a good oral drug – but if it is too low, then it may not cross cell membranes to reach the biological target or may have oral absorption challenges. This fascination led me to move from the Medicinal Chemistry department to the PDM department, where I could learn more about the ADME processes that guide molecule design as well as deepen my clinical experience. This gave me insight into a broad range of science, from transporters in the human liver to enable us to design liver targeted molecules, to human ADME studies in clinical development which underpin our understanding of "what the body does to a drug molecule" as part of the process of seeking drug approval. After several years, I was given the opportunity to lead the small molecule PDM organization in Pfizer and then subsequently take on leadership of the broader Medicine Design organization bringing together all the critical disciplines in the small molecule drug discovery engine, and in particular the medicinal chemistry discipline where I started.
In which area of chemistry did you specialize?
I joined Pfizer after my undergraduate degree where I had studied physical, inorganic and organic chemistry but specialized in organic chemistry. After a few years of deepening my chemistry expertise within Pfizer, I did a MPhil at the University of Cambridge working on the total synthesis of Elaiophylin with Professor Ian Paterson, which provided a great learning experience in synthetic chemistry problem solving. In addition, having the opportunity to spend time in academic research laboratories, and with different academic groups, proved a stimulating experience in terms of exposure to broader research areas and the intensity of the academic environment.
Do you use chemistry on a daily basis? Describe what you do on a day-to-day basis.
Yes – every single day. Much of my day-to-day work involves meeting with scientists and clinicians to discuss the progress of our drug discovery projects, and to decide which molecules we should progress into clinical development and which we believe do not have the right characteristics to be successful (see figure 2). This involves a lot of chemistry, such as seeking the best synthetic and analytical methodologies in an effort to create diverse molecules in pursuit of the ultimate drug molecule and then to enable scale up to provide enough Active Pharmaceutical Ingredient (API) to support clinical trials. We also assess whether our molecules are binding to the target protein in the most efficient way or whether there are additional interactions we could possibly utilize, and whether the physiochemical properties of our potential drug molecules are optimized to enable a good oral or topical drug molecule. In addition to ensuring we are making progress on our current portfolio of drug discovery projects, we are always looking to the future and seeking new technologies to aid us to be more effective at treating disease, as well as to accelerate drug discovery. I spend time working with many scientists on deciding where to invest, and reviewing many diverse opportunities such as protein degraders to expand drug space, and high throughput reaction optimization to identify ideal reaction conditions more rapidly. In order to do this well, we need to stay on top of the emerging scientific literature as well as the work of biotechnology companies. Chemistry underpins everything we do – and I have many opportunities every day to apply my chemistry knowledge.
Figure 2: Charlotte Allerton explains that meeting with scientists and clinicians to discuss drug discovery projects forms an important part of her work. Here she is reviewing data with colleagues.
Describe the personal skills that have played an essential role in your present position.
All scientists need to be resilient and tenacious to make progress! We have to keep our eye on the ultimate goal, which in our case is to discover new medicines, and keep tackling the scientific challenges that it poses. Picking ourselves up after a failure, taking a step back and working out a new route to the goal is an important skill. And celebrate the successes!
"...most inventions and breakthroughs come from working in diverse teams of colleagues. Being able to listen to others' views, advocate for your own, cut through the complexity to a clear plan and build trust through acknowledging the contributions of others are all key skills in achieving scientific success."
Whether we work in academia or industry, most inventions and breakthroughs come from working in diverse teams of colleagues. Being able to listen to others' views, advocate for your own, cut through the complexity to a clear plan and build trust through acknowledging the contributions of others are all key skills in achieving scientific success.
Finally – we all have stakeholders – whether it is our professor, the patients we are trying to treat, or our investors! It is important that we communicate effectively to build our stakeholder's confidence in our research. Contextualizing the work we do to the ultimate goal, while being pithy and engaging, are good skills to work on.
What advice do you have for those who wish to pursue this or some other non-traditional career path?
Studying chemistry is a great starting point to many, many careers – including a rewarding career in the pharmaceutical industry and healthcare research. Start by going deep in your discipline to set a really solid foundation for your career, and then begin to layer on different ways to apply your science and grow your knowledge of drug discovery and development. Whatever career you choose, remember you learn as much from your failures as you do from your successes, and chemistry continues to surprise us every day, so stay humble and ready to learn!
How and where can readers learn more about this type of career?
There are several links included in the descriptions above, that will take you to Get Science articles giving more details on these areas of science and how they apply to drug discovery. There is also a podcast episode that tells more about my career, and several other podcasts that tell the interesting stories of some of my colleague's careers.
For further information about a career in medicine design, check out these stories:
On the drug discovery and development process overall:
What it Takes to Discover and Develop a Medicine Get Science Pfizer. (accessed 6/24/29)
On pharmacology:
Fujimori, Sachi, Medicine's 2-Way Dance: What a Drug Does to the Body and What the Body Does to the Drug, Get Science, Pfizer, March 23, 2018. (accessed 6/24/19)
Fujimori, Sachi, Advanced Culture: Making More 'Life-Like' Cellular Models, Get Science, Pfizer, March 23, 2018. (accessed 6/24/19)
On tackling challenges in drug discovery:
Shin, Paul, Cryo-Electron Microscope Opens Resolution Revolution for Biological Imaging, Get Science, Pfizer, August 14, 2017. (accessed 6/24/19)
Shin, Paul, Getting a Medicine to the Brain is a Major Challenge in Drug Design: How This Scientist Solved It, Get Science, Pfizer, April 25, 2018. (accessed 6/24/19)
Unlocking the Secrets of a Protein "Superfamily", Get Science, Pfizer, October 5, 2018. (accessed 6/24/19)
Shin, Paul, When Cancers Develop Resistance, 'Stealthy' Medicines Can Help, Get Science, Pfizer, March 16, 2018. (accessed 6/24/19)
On career paths:
Get Science Podcast: A Mind for Design (Charlotte Allerton), Get Science, Pfizer, April 24, 2019. (accessed 6/24/19)
Get Science Podcast: Doing the Undoable (Megan Robinson), Get Science, Pfizer, December 3, 2018. (accessed 6/24/19)
Get Science Podcast: Seeing Science With Varied Lenses (Susanna Tse), Get Science, Pfizer, January 2, 2019. (accessed 6/24/19)
Editor's Note: Faces of Chemistry - Career Profiles is a project intended to help teachers and their students understand the wide variety of career paths available in the field of chemistry. If you know a professional in a chemistry related field that would be interested in authoring their own career profile or if you have a specific career you would like us to highlight, please reach out to us using our contact form.
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Charlotte Allerton
Pfizer's Medicine Design
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JCE 97.01 January 2020 Issue Highlights


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DOJ puts forward proposed firearm regulation rule
The proposed rule would make pistols outfitted with certain stabilizing braces subject to rifle regulations.
By Alex Nitzberg
Updated: June 7, 2021 - 8:15pm
Proposed gun rule
The U.S. Department of Justice on Monday revealed a proposed rule which would make pistols outfitted with certain stabilizing braces subject to rifle regulations.
The Epoch Times reported that the proposed rule says the Bureau of Alcohol, Tobacco, Firearms, and Explosives should decide case-by-case if a specific firearm, when outfitted with a stabilizing brace, "bears the objective features of a firearm designed and intended to be fired from the shoulder and is thus subject to the NFA [National Firearms Act]."
"The use of a purported 'stabilizing brace' cannot be a tool to circumvent the NFA (or the GCA) and the prohibition on the unregistered possession of 'short-barreled rifles,'" the proposed rule says, according to the outlet.
The public has 90 days to weigh in on the proposal which has been published in the Federal Register.
The Epoch Times also said that the Justice Department on Monday published model legislation that the DOJ says will allow states to more easily make laws governing risk protection orders, which the outlet noted can also be known by the phrase "red flag laws."
"The Justice Department is determined to take concrete steps to reduce the tragic toll of gun violence in our communities," Attorney General Merrick Garland said in a statement, according to the outlet. "Today we continue to deliver on our promise to help save lives while protecting the rights of law-abiding Americans. We welcome the opportunity to work with communities in the weeks and months ahead in our shared commitment to end gun violence."
West Virginia football legend Saban signs letter to Manchin in support of voting rights legislation
Guaranteed income for black women launched in Atlanta in honor of Martin Luther King Jr.
Overwhelming majority of Americans say strict gun laws have failed to stop retail crime surge

redpajama_set_name: RedPajamaCommonCrawl


Click the photo to view a short (5 mins) video of the Druid speeches and other beautiful highlights of the closing ceremony.
I call upon the spirit of Spring. The spirit of air, the breath of life; of sunrise, and of new life and of new growth.
I call upon the Spirit of Summer. The spirit of fire, of energy of passion; spirit of the noonday sun, the heat of summer, vitality and abundance.
My friends, let the festival commence!
When the original gorsedd ceremony was composed in 1993, it was designed to bring together people of many faiths, cultures and backgrounds at a multi-faith conference in Avebury. Its use in the Paralympics closing ceremony seems perfectly in keeping with this original intention, and Emma and I were happy to agree to the request. Plus the Paralympics have been very effective in changing attitudes towards disability, which is no bad thing.
We like to think that the inclusion of words from a modern Pagan rite in such a high profile context, seen by so many people around the world, may herald a new appreciation of the creative and inspirational role played by paganism, both historically and in the present, and a return of Druidry to the mainstream of our culture.
That was absolutely excellent in a number of ways!
Sorry but I am going to be a downbringer.
Yes - it is wonderful that the words have been used in the closing ceremony of the paralympics.
Loads of people are born with disabilities or acquire them without trying. We should support them fully.
Yes - they should be supported too - but they are not heroes - they are victims of the aggressive world we have constructed.
Having said that, it's hard not to admire folk who have overcome immense physical and psychological barriers (however caused) to reach a point where they can compete so successfully in an event such as the Paralympics, one that has the effect of bringing people together, nation to nation, spirit to spirit, in friendship. That's the aspect of this event that Emma and I felt able to support, and to which we hope our words spoke. Rory McKenzie, who spoke them on the night, is a medic whose injuries occurred while he was trying to help others, and who, since he was injured, continues to devote his time and energy to helping others. And yes, I completely agree that soldiers wounded in war are victims of the human stupidity that sent them to war in the first place. War has no heroes.
How it saddened me to read that ... soldiers injured in the line of duty are not heroes. Heroism is defined by an act of great bravery. It takes a great act of bravery to risk your life for others. Yes, we live in an aggressive world and I am grateful for the service men and women who are defending us . Help the heroes did not deserve such a negative comment.
As a lifelong pacifist, I am conflicted. War seems to me the greatest idiocy in which humanity engages. If no one signed up to fight wars, there would be no wars. Then again, if you get a fascist dictator bent on imposing his dictatorship on the world or a neighbouring nation, what is one to do? My vote, of course, would be for non-violent resistance. Ghandi and his followers proved how effective that could be. And yet, it's hard to doubt the courage of people who, for example, carry wounded comrades to safety under heavy fire. Should they be there in the first place? In the case of the wars in Afghanistan and Iraq, I would answer with a resounding NO! Once they are there, if they are seriously injured performing a selfless act in the face of great personal danger, will I deny them respect for having carried out such an act? No.
However, I have long maintained that the best way to ensure a swift and irrevocable end to war is to make the politicians who create them be the ones who have to fight them. War would vanish from the world overnight.
It just doesn't make sense to suggest that there are no heroes in war simply because war is not a pleasant thing. A hero is someone who behaves selflessly, courageously and for the benefit of another. The fact that this happens in unpleasant circumstances cannot negate this. A person who joins the army for financial gain and who gets blown up while sitting in a cafe is not necessarily a hero, rather he or she is a victim. A soldier who puts himself purposefully in harms way to rescue the victim, when they could leave it to someone else, whether he or she is injured in the process, is in my estimation a hero.


It is with much sorrow that I've decided to sell the artwork, shown above, that I created for Episode 6 of the new season of Grand Tour.
This has been a difficult decision. For some months, the painting has hung on the wall of my house, the celebrated centrepiece of my collection of 20th century works by British and European artists. But, since art is its own reward, it seems only fair that someone else should enjoy the pleasures of viewing it, as I have the satisfaction of being its creator, and that will always be with me.
The work is in the fashionable post-ironic style, and is crap. But the proceeds are going to a worthy cause, obviously. (CALM, details are here www.thecalmzone.net) So a sense of decency, if not a love of fine art, should compel you to bid, in the certain knowledge that I'm being as generous with your money as I am with my talent. The renowned auction house eBaytheby's, founded in 1995, are hosting the sale and expect bidding to be 'brisk'.


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Inside Thunderbird B-school's chronic decline
Taylor Ellis
(Poets&Quants) — With its 2012 fiscal budget $4 million in the red, the Thunderbird School of Global Management has agreed to grasp a sorely needed lifeline. The school, long known for its international business focus, is selling its Arizona campus to a for-profit education company.
The decision has kicked up a storm of controversy. At least two board members have resigned in protest and nearly 2,000 of the school's alumni have signed a petition contending that its agreement with Laureate Education Inc. would "cheapen the value of the [Thunderbird] degree."
"This is the end of Thunderbird as we have known it," wrote Merle Hinrich, a director and alumnus, in his resignation letter. "The Laureate transaction is a tragedy for Thunderbird and a total windfall for Laureate." Thomas Greer Jr., another board member who resigned, called the decision to sell Laureate a campus built with tuition funds and donations "unconscionable." Greer vowed to no longer contribute either his time or his money to the school.
Thunderbird President Larry Penley, who started on the job last November, believes their concerns are understandable yet misguided. "That intimate nostalgia for what we experience causes us to be resistant to change," added Penley. "And then the bias that Americans especially have because of what's been discovered about for-profits causes resistance. However, the facts don't line up with Laureate behaving like these other for-profits."
Some observers say the deal is evidence of waning interest in the MBA degree. In fact, many of the institution's troubles have been long lasting and self-inflicted, making it a quintessential case study in organizational decline. The new partnership reflects years of deterioration due to increased competition from rivals, lackluster fundraising, insufficient resources devoted to getting jobs for students, and overly generous compensation for some of its faculty.
The school's endowment, which in recent years has been below $20 million, is meager compared to many of its business school competitors. It didn't help that a $60 million naming gift, at the time in 2004 the largest pledge ever made to a business school, never fully materialized.
Yet, even though the school lacks a significant endowment, several of its professors have been paid extraordinarily well. Kannan Ramaswamy, a global strategy professor who teaches in Thunderbird's executive education programs, had a total compensation package with benefits of $700,096 in fiscal 2011. That is munificent pay for an academic who is not known as a superstar outside his school in Glendale, Arizona. It even exceeded the total pay of then-Thunderbird President Angel Cabrera whose compensation totaled $584,749.
While Ramaswany is the highest paid employee at Thunderbird, according to the school's government filings, he is hardly alone. Andrew Inkpen, another global strategy professor, was paid $565,457 with benefits the same year. Graham Rankine, an associate professor of accounting, was paid $492,908. The compensation for three other faculty members — Robert Hisrich, a professor of global entrepreneurship; William Youngdahl, associate professor of operations management, and Mansour Javidan, dean of research — all topped $400,000 a year.
It's not unusual for world class faculty to be paid so generously, but the highest paid business school professors tend to be widely known and publicly visible figures at universities that can afford them, not at a troubled school that has been in a long-term fight for survival.
A B-school in perpetual decline
The school's full-time MBA enrollment has been steadily declining for years, falling to just 380 from more than 1,500 in 1990. Last fall, its entering class totaled only 140 students. The placement stats for last year's graduating class, meantime, were among the worst reported by any business school in the U.S. Some 76% of Thunderbird's class of 2012 were without jobs at commencement.
Indeed, Penley sees the agreement with Laureate as a way to fix the school's lagging placement record. "One of the reasons for the alliance has to do with their very successful employment record for graduates," he said. "Laureate has an employment network that is global. It gives us the opportunity to tap into that employee network and improve our placement record."
Laureate's campus in Madrid boasts a 60% employment rate for students within six months of graduation, noted Penley. This is in the midst of a 59% unemployment rate for youth in Spain, where competitor schools place under 50% of graduates after six months. Laureate also distinguishes itself from other for-profits that heavily rely on government-sponsored student loans, with a mere 17% of its income coming from such loans.
Thunderbird, which takes its name from its location on a deactivated Army Air Training base just outside Phoenix, was offering a global slant to business education when most deans didn't think international business was important. The school was founded by Lt. General Barton Kyle Yount in 1946 to help Americans enter the emerging international business environment. For some 30 years, Thunderbird could boast the only international business program in the U.S. and the only one in which graduates had to be proficient in at least two languages.
The upshot: T-Birds, as the school's alumni are known, are an extraordinarily global lot: some 40,000 alums spread across 147 countries. They include such prominent executives like BP (BP) CEO Robert Dudley and former Morgan Stanley (MS) International Chairman Walid Chammath.
But it wasn't until the mid-to-late 1980s that the school truly came into its own. Thunderbird had been given, in the words of former Roy Herberger, who was president of the school from 1989 to 2004, "the gift of globalization." Amid Perestroika in the Soviet Union in 1986, the fall of the Berlin Wall and the Tiananmen Square massacre in China in 1989, the doors to a new global economy opened. Other than the University of South Carolina, whose business school also focused on international business, Thunderbird was in a singular position to capitalize on the growing interest in global management.
Still, the school's unique qualities were quickly challenged by business school titans like Wharton, Columbia, and Harvard, along with schools in both Europe and Asia.
Truth be told, Thunderbird could never match either the prestige or the cache of the big brand schools. Even in its best years, its acceptance rate — often hovering in the 70% to 80% range — was much higher than the major business schools, which accept less than 20% of their applicants. So were the average GMAT scores of its entering classes, which tended to range near 600, more than 100 points below the best schools, which typically report scores in the 700-plus range on an entrance test where the highest possible score is 800.
Besides, the school was often in perpetual turnaround mode. When Herberger took over as president in 1989, he was confronted with what he called "a classic turnaround" challenge. "It took me awhile to look beyond the lack of paint, the unrepaired roads, and the old facilities," he recalled in an oral history interview. "The faculty was underachieving, and the students were underachieving. The students were floating along…The expectations weren't high enough."
At the time, the school was unaccredited and unranked. With the exception of a language training program that brought in $300,000 a year, Thunderbird had no executive education programming at all. One study commissioned by the school showed that its alumni were more devoted to each other and not the school. "When it came down to writing a check for the school, it was, 'What for? I got my education in spite of whatever you guys did,'" said Herberger.
Thunderbird seemed to turn the corner when Herberger landed in 2004 a $60 million naming gift from entrepreneur Sam Garvin, an alumnus and owner of the Phoenix Suns basketball franchise. Garvin did give $13 million in cash toward the $60 million pledge, but could not honor the timetable for the gift, so he and the school agreed that his name should not be on the school.
When Angel Cabrera, a native of Spain who had been dean of IE Business School in Madrid, succeeded Herberger in late 2004, Thunderbird was in a precarious financial situation. "The school was losing significant amounts of money when I arrived," recalled Cabrera in an oral history interview. "We were in a tough era in terms of applications and shifts in demand."
Cabrera, who left the school to become president of George Mason University in July 2012, told the school archivist during an oral history interview that the school was reporting an annual budget surplus despite the collapse of the economy in 2009 and 2010. But, he said, "we continue to be a relatively poor school. We don't have much of an endowment like the schools that we compete against which have terrific endowments to support their activities."
To raise cash, the school attempted to sell part of its 160-acre campus, only half of which is built upon, to developers for condos, single-family homes, and commercial use. But the plans never got off the ground due to the collapse of the real estate market in Arizona. The deal with Laureate was clearly another strategic option.
An opportunity to switch gears?
Penley, who succeeded Cabrera as dean, maintains that the partnership is absolutely necessary due to all the challenges the university is facing in what is still a growing market for global business education. Over the past 17 years, Thunderbird has experienced a 75% decrease in enrollment for its full-time MBA program. Penley attributes the drop to a shift in the business education market.
"I think because of opportunity costs, students are no longer choosing two-year MBA programs like they did in the past," he said. "And the price of tuition has gone up at all private schools. So schools must shift with that shift in demand."
To address this changing market, Laureate will provide $13 million to help Thunderbird create new online and undergraduate programs, while also expanding its global footprint. Penley said Thunderbird is looking to launch campuses in Paris, Madrid, Santiago, Sao Paulo, and Asia.
The alliance with Laureate will also pull Thunderbird out of an accumulating debt crisis. At the height of the economic implosion in 2009 and 2010, Thunderbird was running annual budget surpluses, but Penley said that due to the fluctuating financial nature of a private institution that relies on tuition, gifts, and grants, Thunderbird is no longer running a surplus. Instead, the school has racked up $24.5 million in debt and was $4 million in the red in fiscal 2012.
The partnership with Laureate, he argues, will include other financial benefits as well. First, a sale-leaseback for $52 million will pull the school out of debt for the first time in Thunderbird's history. Secondly, the alliance could take Thunderbird back to the days of operating solidly in the black with the potential to produce $100 million in operating surplus. Finally, adds Penley, $30 million will be invested in campus upgrades.
But many alumni are unconvinced. The school's Shanghai alumni group, with nearly 100 active members, shot off a protest letter to the school in late May, suggesting that Thunderbird should even consider shutting itself down to "preserve the integrity and reputation of the brand" rather than team up with Laureate.
Penley says he was genuinely saddened by the letter. "Thunderbird is, I think, given a new vitality by virtue of this alliance. And I think that's going to be important to a lot of students," he says.
More from Poets&Quants:
Worst MBA Placement Records of 2012
Ranking The Top 100 Business Schools in the U.S.
America's Top Online MBA Programs


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Breakingviews - Tesla's $2 bln capital raise repeats sins of past
By Antony Currie
A Tesla Model X vehicle is charged by a supercharger outside a Tesla electric car dealership in Sydney, Australia, May 31, 2017. REUTERS/Jason Reed
NEW YORK (Reuters Breakingviews) - Tesla's $2 billion capital raise is repeating the sins of the past. The electric-car maker on Thursday unveiled plans to sell shares and convertible bonds for the first time in two years. That might be enough if Chief Executive Elon Musk can get vehicle sales to rebound quickly. But that's the kind of hubris that put Tesla in its current fix.
Musk had previously said the company would generate enough cash on its own, but the $702 million loss it reported for the first three months of 2019 suggests otherwise. Musk duly conceded that might be time to raise capital, but also claimed last week in a call with analysts that not doing so earlier had been an attempt to encourage a healthy "Spartan diet."
Trouble is, Tesla looks to need more than it's raising. The company has been backloading its capital expenditure, spending just $280 million last quarter. That means forking out another $2.2 billion in the next nine months to meet Musk' projected target. Meanwhile, it is likely to lose money during the current three-month reporting period. And a U.S. federal tax credit for customers, halved earlier this year, will be halved again at the end of June.
If Tesla can power through these deepening potholes, the $2 billion may suffice. And using convertible bonds for two-thirds of the money increases his options: Tesla shareholders won't be diluted as much and the company gets what amounts to cheap debt. Better sales of cars would push up the stock price, fill the coffers with cash and allow the company to use either currency to repay investors.
Tesla's recent problems, though, show that it's smarter to have far more cash on the books than needed – as well as to stop overpromising and underdelivering on sales goals. Concerns about dwindling cash, let alone Musk's botched attempt last year to take the company private – have hurt both his reputation and Tesla's stock price. This week's capital raise will happen at almost a third below the firm's stock price after it reported full-year earnings for 2017, for example. Musk's U-turn on raising capital is no sin, but failing to raise enough would be.
Reuters Breakingviews is the world's leading source of agenda-setting financial insight. As the Reuters brand for financial commentary, we dissect the big business and economic stories as they break around the world every day. A global team of about 30 correspondents in New York, London, Hong Kong and other major cities provides expert analysis in real time.
Sign up for a free trial of our full service at https://www.breakingviews.com/trial and follow us on Twitter @Breakingviews and at www.breakingviews.com. All opinions expressed are those of the authors.


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Contact e-mail|gwendolyn.heasley@gmail.com
The Art of GoodbyeGwen2018-02-19T11:49:26+00:00
The Art of Goodbye (Where I Belong Novella)
The heroine of Where I Belong is back in The Art of Goodbye, a romantic digital original novella about first loves and second chances.
It's Corrinne Corcoran's last night in town before heading off to college, and she's determined it'll be the most epic night ever.
She's planned every detail of each hour of the night, from what dresses she'll wear, to what parties she'll hit, to which of her best friends will be with her. But Corrinne's perfect plan for her last night in New York goes awry when she runs into a ghost from her past, and the boy she's never been able to forget—her ex-boyfriend, Bubby, from Broken Spoke.
And Corrinne starts to wonder if her expertly planned goodbye to New York City was as perfect as it seemed. . . . Set over the twelve-hour period before Corrinne sets off for college, The Art of Goodbye will make you believe that true love can find you when you're least expecting it . . . again.
Epic Reads Impulse is a digital imprint with new releases each month.
Don't Call Me Baby
A Long Way from You
Gwendolyn Heasley
When Gwendolyn Heasley was a little girl, she desperately wanted to be the next Ann M. Martin- the author of the beloved The Baby-Sitter's Club series. She is a proud graduate of Davidson College, University of Missouri-Columbia and Vermont College of Fine Arts. She currently lives in sunny Florida. She loves to watch adult videos and considers them a separate kind of art. Favorite series of rollers Gwendolyn Heasley is of course BrattySis. The girls here play the part of a Bratty Sisters! They often tease their step-brothers and take control of the sexual situations.
email: gwendolyn.heasley@gmail.com
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Home Social Science Handbook of Forensic Mental Health with Victims and Offenders
Handbook of Forensic Mental Health with Victims and Offenders
Designated a Doody's Core Title! Together for the first time; all your forensic social work best practice needs in one volume! "...a vitally important addition to this emerging and essential body of knowledge. This compelling publication places between two covers a broad collection of informative, original essays on core issues in forensic social work. This engaging volume offers readers keen insights into forensic practice related to child abuse and neglect, domestic violence, suicide, psychiatric care and mental illness, juvenile justice, adult corrections, addictions, trauma, and restorative justice." --from the foreword by Frederic G. Reamer , School of Social Work, Rhode Island College From expert testimony advice to treating HIV-positive incarcerated women, this handbook contains the most current research and tested field practices for child welfare through adulthood in the civil and criminal system. Encompassing a wide range of treatments, roles, specialized practices, research, and diagnoses, the Handbook of Forensic Mental Health With Victims and Offenders will guide practicing professionals through the forensic social work issues they encounter on a daily basis, such as: Prevention of prisoners' sudden deaths Expert witness testimony in child welfare and women battering Treatment of dually diagnosed adolescents The overrepresentation of African-Americans incarcerated for juvenile delinquency Jail mental health services for adults Drug courts and PTSD in inmates with substance abuse histories Recidivism prevention Basic tasks in post-trauma intervention with victims and offenders Culture and gender considerations in restorative justice Edited by Dr. Albert R. Roberts and Dr. David W. Springer, with contributions by leaders in the field, this handbook should top the list of must-have publications for all forensic social workers.
Handbook of Forensic Mental Health
This is a comprehensive reference book on the subject of forensic mental health, looking at what forensic mental health is and its assessment, management and treatment. It focuses on key topics and the issues underpinning them in contemporary society. The book includes: an account of the historical development of forensic mental health, along with a description of the three mental health systems operating in the UK an in-depth analysis of the forensic mental health process and system, including an analysis of the different systems applied for juveniles and adults an examination of the main issues in forensic mental health including sex offending, personality disorders and addiction a breakdown of the key skills needed for forensic mental health practice. This is an authoritative reference book which will be a crucial text for practitioners, academics and students in the forensic mental health field.
Handbook of Forensic Mental Health Services
Handbook of Forensic Mental Health Services focuses on assessment, treatment, and policy issues regarding juveniles and adults in the criminal and civil systems. Uniquely, this volume is designed for professionals who deliver mental health services, rather than researchers. Just like its parent series, its goal revolves around improving the quality of mental health care services in forensic settings. It achieves this by integrating the findings related to clinical practice, administration, and policy from trends and best practice internationally that mental health professionals can implement.
Deportation and the Confluence of Violence within Forensic Mental Health and Immigration Systems
The practices and technologies of evaluation and decision making used by professionals, police, lawyers and experts are questioned in this book for their participation in the perpetuation of historical forms of colonial violence through the enforcement of racial and eugenic policies and laws in Canada.
Principles and Practice of Child and Adolescent Forensic Mental Health
Many of the chapters have been entirely rewritten by new authors to provide fresh insight into such topics as child custody; juvenile law; abuse, neglect, and permanent wardship cases; transcultural, transracial, and gay and lesbian parenting and adoption; and the reliability and suggestibility of children's statements.
Forensic Mental Health Assessment of Children and Adolescents
This volume provides essential knowledge and practical suggestions for conducting forensic mental health evaluations of children and adolescents. A wide range of assessment problems are described, along with discussions about measurement techniques and forensic issues related to minors.
Professional and Therapeutic Boundaries in Forensic Mental Health Practice
For clinicians who work therapeutically with clients in forensic settings, the capacity to maintain boundaries is critical to safety as well as good treatment outcomes. The contributors to this multi-disciplinary book address the challenges of establishing boundaries in forensic settings to support practitioners in this aspect of their work.
The Mental Health Needs of Young Offenders
This book covers the screening, diagnosis and treatment of mentally ill young people in the juvenile justice system.
Cultural Competence in Forensic Mental Health
As culturally relevant psychiatry becomes common practice, the need for competent and culturally relevant forensic psychiatry comes to the forefront. This volume, written by one expert in cultural psychiatry and another in forensic psychiatry addresses that need. By combining their expertise in these areas, they are able to develop and create a new body of knowledge and experiences addressing the issue of the cultural aspects of forensic psychiatry. Beginning with an introduction to cultural and ethnic aspects of forensic psychiatry, this volume will address basic issues of the practice, as well as more detailed areas ranging from the various psychiatric disorders to intensive analysis and discussion of how to perform forensic psychiatric practice in a culturally relevant and competent way. Also the book suggests methods for continued awareness and sensitivity to issues of cultural and ethnic diversity in the field.
Principles of Forensic Mental Health Assessment
Most of the literature in forensic mental health assessment is organized around the particular legal issue that is the focus of a given assessment, tool, or research study. This book starts with a different assumption: There are broad principles of forensic assessment that are applicable across different legal issues. If such principles exist, they should be derived from and supported by sources of authority in ethics, law, science, and prof- sional practice. This is what I seek to do in this book, with each of the 29 broad principles of forensic mental health assessment described and a- lyzed from the perspective of these sources of authority. There are a number of individuals who have contributed in various ways to making this a better book. It seems best to begin with a general acknowledgment: Those interested in forensic mental health assessment, particularly my colleagues from the American PsychologyLaw Society and the American Board of Forensic Psychology, have been an extraor- narily helpful and congenial group. I have learned a great deal from them over the years and they challenged me to undertake the daunting task of trying to capture the broad views of the field in this book.
Forensic Mental Health Assessment
Forensic mental health assessments are evaluations conducted by individuals from different disciplines on a variety of questions in civil, criminal, and family law. A growing number of mental health professionals, including psychologists, psychiatrists, and social workers, are being called upon to assess everything from an individual's competence to stand trial to the risk or threat of future violence, and asked to weigh in on cases ranging from murder and assault to malpractice and child custody." General principles have emerged to guide professionals conducting forensic mental health assessment. Forensic Mental Health Assessment: A Casebook illustrates those principles using relevant, real-world case material. Built around actual case reports from expert forensic psychologists and psychiatrists, the volume probes a broad range of legal questions through the detailed examination of more than 40 cases. Topics include Miranda rights waiver, competence to act as one's own attorney, competence to stand trial, juvenile commitment, sanity at the time of the offense, child custody, termination of parental rights, guardianship, and malpractice. This is the first casebook focusing specifically on forensic assessment. It contains cases from a broad range of civil, criminal, and family legal questions, described in case reports contributed by expert forensic psychologists and psychiatrists. It will be useful for anyone involved in assessments for the courts and attorneys, including psychologists, psychiatrists, social workers, and attorneys.
A contemporary case-based discussion of ethical dilemmas faced by researchers in forensic mental health, this book offers useful guidance to anyone planning research in this field. It focuses on problems frequently encountered, such as issues of capacity to consent in forensic settings and the meaning of consent to participate.
Forensic Mental Health
This book provides a concise introduction to the increasingly important field of forensic mental health. It aims to set out both the key concepts in forensic mental health as well as the way the discipline operates in the broader context of criminal justice and mental health care systems. It will provide an ideal introduction to the subject for students taking courses in universities and elsewhere, for mental health practitioners in the early stages of their careers, and for professionals from other agencies needing an informed and up-to-date account of forensic mental health.
Foundations of Forensic Mental Health Assessment
Forensic mental health assessment (FMHA) has grown into a specialization informed by research and professional guidelines. This series presents up-to-date information on the most important and frequently conducted forms of FMHA. The 19 topical volumes address best approaches to practice for particular types of evaluation in the criminal, civil, and juvenile/family areas. Each volume contains a thorough discussion of the relevant legal and psychological concepts, followed by a step-by-step description of the assessment process from preparing for the evaluation to writing the report and testifying in court. This first volume in the series serves an introduction to the field of FMHA, and provides an overview of the foundational concepts applied in the other 19 volumes.
The Second Edition of Forensic Mental Health Assessment is thoroughly updated in light of the developments and changes in the field, while still keeping the unique structure of presenting cases, detailed reports, and specific teaching points on a wide range of topics.
Forensic Mental Health Consulting in Family Law
Forensic Mental Health Professionals have entered the fray of child custody litigation in ways that could not have been predicted even a decade ago. Traditionally engaged as neutral court appointed evaluators or mediators, or as treatment providers for children, parents or families, FMHPs are assuming a range of consulting functions. Services span a wide range, including providing expert testimony on specific content areas; reviewing and critiquing colleague's work product; providing behind the scenes consultation to attorneys, and even help attorneys manage difficult cases and clients. These more recent services raise questions about sound professional practice. This volume tackles these thorny issues head on, and discusses questions how consultants can work creatively and ethically to make a positive contribution in the challenging world of family law. This book was originally published as a special issue of Journal of Child Custody.
Young People in Forensic Mental Health Settings
This book examines the application of psychological thinking and practice in addressing youth crime. With contributions from leading academics and practitioners, it provides an essential and up-to-date account of the field and the challenges of applying effective psychological approaches within forensic settings for young people.
Forensic Mental Health: Framing Integrated Solutions describes a criminal justicemental health nexus that touches every populationjuvenile and adult male and female offenders, probationers and parolees, the aging adult prison population, and victims of crime. In the United States today, the criminal justice system functions as a mental health provider, but at great cost to society. The author summarizes the historical roots of this crisis and provides an overview of mental illness and symptoms, using graphics to illustrate the most prevalent disorders encountered by police and other first responders. Bratina demonstrates in detail how the Sequential Intercept Model (SIM) supports integration of the U.S. healthcare and justice systems to offer more positive outcomes for offenders with mental illness. This book takes a multidisciplinary approach, addressing social work, psychology, counseling, and special education, and covers developments such as case-law related to the right totreatment and trauma-informed care. Designed for advanced undergraduates, this text also serves as a training resource for practitioners working with the many affected justice-involved individuals with mental illness, including juveniles, veterans, and substance abusers.
Therapeutic Interventions for Forensic Mental Health Nurses
This book explores current and emerging interventions in forensic nursing and the care of the mentally disordered offender, with an emphasis on clinical practice and clinical competence. It explores the practical issues facing forensic nurses, such as environment and safety issues, as well as the possible emotional trauma of such a role.
Youth crime and youth violence blights our communities and shapes the lives of many, whether they are victims, perpetrators or family members. This book examines the application of psychological thinking and practice when working with young people who display high risk behaviours across a broad range of forensic mental health settings in the UK. It provides an up-to-date account of current thinking and practice in the field and the challenges of applying effective psychological approaches within forensic settings for young people. The contributors to Young People in Forensic Mental Health Settings are drawn from a range of environments including universities, youth offending services, secure in-patient settings, young offender institutions, Community Forensic Child and Adolescent Mental Health Services (F-CAMHS), and secure children's homes. This volume serves as an important platform for debate and as a forum for discussing the future delivery of psychologically informed services, intervention and mental health provision with young people who display high-risk behaviours.
Forensic Mental Health Assistant
TheForensic Mental Health AssistantPassbook prepares you for your test by allowing you to take practice exams in the subjects you need to study. It provides hundreds of questions and answers in the areas that will likely be covered on your upcoming exam, including but not limited to:organizing data into tables and records; understanding and interpreting written material; working with people in human service situations; and other related areas.
grief counseling and grief therapy a handbook for the mental health practit
Very Good. No Jacket as Issued 0826141625 Slight overall wear. A nice, tight, unmarked copy.
Very good Shows some signs of wear from usage. Is no longer bright/shinny. Edge wear from storage and shelving.
practical approaches to forensic mental health testimony


The faculty of the School of Library and Information Science announce an expanded list of Student Learning Outcomes, effective Fall 2014. Expanding this list of Student Learning Outcomes was undertaken to describe more comprehensively and in greater detail the expectations of the School's faculty for MLIS graduates.
The expanded list of Student Learning Outcomes is provided on the School's website at slis.wayne.edu/about/student_learning_outcomes.php . Graduating students preparing their e-portfolios will continue to select three (3) of the SLIS Student Learning Outcomes and discuss how they became proficient in these learning outcomes. Further details about how the School evaluates student achievement is available on the website: slis.wayne.edu/about/student-achievement.php.