text:
Before you head to the couch to watch college football, take a short stroll through some of the MSU-related and maybe-not-so-MSU related miscellany that the internet has to offer.
By EthanLee@leeethanj Sep 17, 2016, 8:30am EDT
Morning Linkage
We predicted week three of the SEC- This is a weekly thing that we do. We pick every outcome for the SEC games that week and then invite you to join us in our endeavors. I promise, we're 100% right this time.
Mississippi State is recognizing former football players in the NFL- First Dak Prescott. Now Malcolm Johnson. Who will be next? Probably a former Mississippi State player, if I had to guess.
Justin Strawn generated a lot of discussion about music- He has since described this as one of his greatest accomplishments. Let's celebrate that.
Shaq wants LSU to find a quarterback- Shaq would also be more enjoyable to watch at quarterback than Danny Etling and Brandon Harris combined. Despite that, he'd probably still be awful. But at least he would be entertaining.
Mississippi State Volleyball is 7-5- The women's volleyball team has run into some tough opponents to open the season up, but they're slowly starting to improve and they found a way to take both matches from Friday. Now they've got another two matches today.
DON'T TRY THIS AT HOME SATURDAYS
DON'T CUT YOUR HAIR WITH A DRONE
Simone Giertz is a goofy individual that makes awful robots that kinda get their job done. She attached hair cutting devices to a drone. I've messed around with a drone before. They're not easy to fly. Don't cut your hair with one. There is some strong language, but it's nothing you wouldn't hear at a college football tailgate.
Saturday's Songs
Today's song? Well it's a very obvious choice. LSU even uses it for their pregame video. Pod Katt of And the Valley Shook has a video of it from the 2014 season. (Hopefully today's game is something like our 2014 game against LSU)
Also, bonus song:
Stressed Out by 21 Pilots. Because we'll all be stressed tonight. Hopefully LSU fans will be more stressed though.


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Recruitment: Police extend deadline, beg Nigerians to apply
The Nigerian Police Force has expanded online registration in the ongoing 2021 recruitment exercise for interested and eligible Nigerians serving the Force as police officers.
Police Public Relations Officer Frank Mba, in a statement on Wednesday, said that the new deadline for registration on the portal is now Saturday, January 22, 2022.
According to him, the extension of the term was informed by the need of the applicants from the Southeast and South-South to fill their quota.
"With this extension, the NPF recruitment portal will remain open until midnight on the new date," added Mba.
"The extension of the online application is based on the need to guarantee equal opportunities and even the dissemination of applications, in particular from the southeast states, the south-south geopolitical zones and the state of Lagos, to allow them to fulfill with the required fee for their respective areas.
"A statistical analysis shows that a total of 81,005 applications were received nationwide as of January 7, 2022. Of this number, only 1,404 applications were received, less than 2 percent of the total applications, from the five southern states. . East and 261 from Lagos State, with Anambra State with the lowest number of 158 applicants.
"Accordingly, the Force directs state and local governments, religious bodies and other interest groups in the affected geopolitical areas and Lagos State to help mobilize and encourage their citizens and wards to seize the opportunity to pursue a career. professional in the Nigerian Police. Force. Interested applicants are urged to log into the NPF recruitment portal to register before the new deadline expires.
"In addition, applicants are recommended to call 08100004507 for any questions, complaints or technical difficulties in using the portal.
"The recruitment exercise is absolutely free."
Short Link: https://wp.me/pcj2iU-3GPR
Related Topics:AnambraLagosNigerNPF
Akeredolu petitioned over Olore Chieftaincy tussle
ICPC secures forfeiture of N110.4m traced to primary school teacher, others
Electoral Bill: Senate will expedite action, expeditiously look into grey areas – Lawan
Nigerian govt to begin nationwide distribution of 10million gas cylinders

redpajama_set_name: RedPajamaCommonCrawl


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Q: Using Orthogonality of Legendre Polynomials to determine a Recurrence Relation This is something that I've been struggling on for a few hours now and would appreciate any help:
Rodrigue's formula:
$P_n(x)$ = $ \frac{1}{2^nn!} \frac{d^n}{dx^n}(x^2-1)^n $
The Legendre polynomials (given by the above formula) $ \{P_0,...,P_n\} $ form an orthogonal basis of the space of all polynomials of degree at most $n$ (integer).
Let $P_n(x) = a_{n,n}x^n +a_{n-1,n}x^{n-1} + ...+ a_{0,n} $
We are given that:
1) The leading coefficient $a_{n,n} = \frac{(2n)!}{2^n(n!)^2}$
2) The polynomial $xP_n(x) $ of degree $n+1$ can be written as:  $xP_n(x) = \frac{n+1}{2n+1}P_{n+1}(x) + Q(x) $
Question: Show that $Q(x)$ is orthogonal to $P_j(x)$ for all $j\geq n-2$.
Conclude that there exists constants A and B such that
$Q(x) = AP_n(x) +BP_{n-1}(x) $
Using the normalisation condition relation $P_n(1)=1$ for all $n \geq 0$, and the fact that $\int_{-1}^{1} x|P_n(x)|^2dx=0$, show that $A=0$ and $B=\frac{n}{2n+1}$. Deduce from this recurrence relation:
$(n+1)P_{n+1}(x) = (2n+1)xP_n(x)-nP_{n-1}(x)$
My attempt:
For orthogonality:
I have considered the inner product of $Q(x)$ and $P_j(x)$ w.r.t weight function $w(x)=1$. However I'm having some issues with the integration and not sure how to proceed with the rest of the question.
$\langle{Q(x)}, {P_j(x)} \rangle$ = $\int_{-1}^{1} Q(x)P_j(x) dx$
=$\int_{-1}^{1} (xP_n(x)-\frac{n+1}{2n+1}P_{n+1}(x))P_j(x) dx$
=$\int_{-1}^{1} xP_n(x)P_j(x) dx - \frac{n+1}{2n+1}\int_{-1}^{1}P_{n+1}(x)P_j(x) dx $
I know that this must equal zero, but how exactly? And also how can we conclude that constants $A$ and $B$ exist such that $Q(x)$ takes the second form?

A: Long ago I answered a similar question detailing these things, see Legendre Equation Properties
.

A: I think $j$ should be equal or less then $n-2$. In fact the actual recurrence formula for legendre polynomials has $Q(x)=\frac{n}{2n+1}P_{n-1}(x)$, so obviously $Q$ can't be orthogonal to $P_{n-1}$.
Since $\{P_0,...,P_n\}$ form a basis of the space of all polynomials of degree at most $n$, wich is orthogonal with respect of the scalar product in $L_2([-1,1])$, we have:
$$<P_{n+1},P_j>_{L_2([-1,1])}=\int_{-1}^1P_{n+1}(x)P_j(x)dx=0$$
for all $j\leq n-2$ for orthogonality. For the other integral consider the term $xP_j(x)$: since $j\leq n-2$ this is at most a polynomial of degree $n-1$ and since $\{P_0,...,P_{n-1}\}$ is a base of the space of all polynomials of degree at most $n-1$ we can rewrite $xP_j(x)=\sum_{i=0}^{n-1}\alpha_iP_i(x)$. Now we use the linearity of the integral and write:
$$\int_{-1}^1xP_n(x)P_j(x)dx=\int_{-1}^1P_n(x)\sum_{i=0}^{n-1}\alpha_iP_i(x)dx=\sum_{i=0}^{n-1}\alpha_i\int_{-1}^1P_n(x)P_i(x)dx=$$
$$=\sum_{i=0}^{n-1}\alpha_i<P_n,P_i>_{L_2([-1,1])}=\sum_{i=0}^{n-1}\alpha_i0=0$$
for orthogonality of $P_n$ on $P_0,...,P_{n-1}$.
This means that $Q(x)$ can't be a polynomial of degree $n-2$ or less , furthermore we have that:
$$0=\int_{-1}^1x|P_n(x)|^2dx=\int_{-1}^1\frac{n+1}{2n+1}P_{n+1}(x)P_n(x)dx+\int_{-1}^1Q(x)P_n(x)dx=\int_{-1}^1Q(x)P_n(x)dx$$
wich means that $Q(x)$ is not of degree $n$. Obviously since $xP_n(x)=\frac{n+1}{2n+1}P_{n+1}(x)+Q(x)$, $Q(x)$ can't have degree higher then $n+1$, so its degree must be $n-1$ or $n+1$ for what we have shown so far.
Now we use the fact that $a_{n,n}=\frac{(2n)!}{2^n(n!)^2}$: since
$$a_{n,n}=\frac{(2n)!}{2^n(n!)^2}=\frac{n+1}{2n+1}\frac{(2n+2)!}{2^{n+1}((n+1)!)^2}=\frac{n+1}{2n+1}a_{n+1,n+1}$$
$Q(x)$ can't have degree $n+1$ or else it would contribute in this equality with the coefficent of its term of power $n+1$, making it false. So $Q(x)$ has degree $n-1$ and must be, for orthogonality properties demonstrated before, $BP_{n-1}$.
Now we conclude observing that $P_n(1)=1$ for all $n\geq 0$, so from the equality $xP_n(x)=\frac{n+1}{2n+1}P_{n+1}(x)+Q(x)$ we have
$$1=\frac{n+1}{2n+1}1+Q(1)=\frac{n+1}{2n+1}+B$$
so $B=\frac{n}{2n+1}$ and we have the recurrence formula.

redpajama_set_name: RedPajamaStackExchange


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English retail entrepreneur and reality TV personality Luisa Zissman leaked nude photos
Luisa Christina Zissman (born Louisa Christina Kalozois; 4 June 1987) is an English retail entrepreneur and reality television personality. She was the runner-up on the ninth series of The Apprentice and appeared in Celebrity Big Brother 13.
Zissman was born in Milton Keynes, Buckinghamshire she went to the Grove Independent school in Loughton Milton Keynes to a Greek father and educated at Northampton School for Girls.
Her first employment was at an estate agent on Saturdays which she took at 16 to pay the upkeep costs for a horse her parents bought for her. One of her first post-school jobs was at Electronic Data Systems, but she later stated that she decided to go into business due to disliking being employed and being told what to do.
Based in St. Albans, Hertfordshire, she owns her own baking website, eBay electronics business and cupcake shop – Dixie's Cupcakery, named after her daughter. Although she claimed on several occasions that these three businesses have a net worth of £1.5 million, The Independent valued the three businesses, all trading names of Boutique Trading Ltd of which Zissman is listed as director and company secretary, at £194. They also noted that the eBay electronics store she owned was a "one-stop shop for several sellers, including electronics, baking and beauty products".
Zissman came to public attention when she appeared on the ninth series of The Apprentice in 2013, where she was runner up. On 23 July 2013, Zissman appeared on BBC Radio 1's Innuendo Bingo. In November 2013 she launched her business, named Bakers Toolkit, at the Cake International Show. Earlier, there had been some debate about whether the name should include an apostrophe. She joined the thirteenth series of Celebrity Big Brother on 3 January 2014. She finished fourth overall behind Jim Davidson, Dappy and Ollie Locke. She has since appeared on Reality Bites and News Thing.
She is divorced from her first husband, entrepreneur Oliver Zissman who co-founded Totally Fitness, a gym equipment rental business with his brother; the couple have a daughter, Dixie, who was born in 2010. While on Celebrity Big Brother, she revealed that she is bisexual, and had sought treatment for sex addiction. Zissman married Irish businessman Andrew Collins in France in July 2015. Their first child together, Indigo Esme Collins, was born on August 2, 2016.
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Over the last few years we've all felt that the risks to our employees when travelling on business has increased. In 2019 a new report has revealed that 47% of organisations believe travel risks are on the rise . Passport to Protection, the new travel safety handbook for business travellers from Cardinus Risk Management, hopes to add another easy way to provide expert safety guidance to travellers to keep them safe.
The travel-size book, which features interactive QR codes and a perforated casualty care card and 'Useful Contacts' sheet, provides easy-to-read, professional guidance for just about any travel situation. It's simple to follow and laid out in a practical and useful way, making it a valuable handbook for travel safety.
Not only does it make an ideal guide for travelling business employees, it's a fun and enjoyable read, ensuring that your employees want to get stuck in and are engaged with the practical advice imparted in the book.
Want some advice staying safe when walking around a foreign city? Perhaps you need advice for working in a potential dangerous part of the world? Or maybe you just want to make sure you don't alarm your hosts with a misplaced handshake? You'll find it all in here in this simple to follow handbook.
Of the book, Andy Neal said, "I wrote this travel safety guide after years of travelling to hostile and not-so-hostile environments and seeing fellow business travellers make mistake after mistake that left them exposed to the risks of a theft, kidnap and other dangers.
The handbook has been launched by Cardinus Risk Management and is available via our website- https://www.cardinus.com/travel-safety-handbook/ - or directly from Cardinus Risk Management. For businesses who would like to discuss white labelling the handbook, it can be requested online.
For more information on Passport to Protection, or to hear more about Cardinus' expertise in organisational and travel safety, speak to Cardinus on 020 7469 0200 or email info@cardinus.com.


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text:
Font of Errors Plagued Awards
M.J. Rose
Loss of funding killed the Frankfurt E-Book Awards, but the concept was flawed from the start. __Also: __New awards on the horizon ... a glut of guilt ... and more in M.J. Rose's notebook.
Last week's announcement that the Frankfurt E-book Awards will be discontinued came as no surprise to the publishing industry. Not much about e-books has met the over-hyped expectations that greeted the birth of the new form in early 2000.
The International eBook Award Foundation (IeBAF), funded 0primarily by Microsoft, blamed the shutdown on the current business environment. "Microsoft told us that their budget did not foresee funding for the foundation," said Alberto Vitale, IeBAF chairman.
While lack of funding killed the awards, the show had a problem that money couldn't resolve: It was an award show created for a new technological form, yet judged on literary merit. That created confusion, especially because, as critics pointed out, many of the judges were unfamiliar with the new technology.
What makes e-books deserving of a separate category is that the new technology has the potential to change the written form by including animated illustrations, video and audio capabilities, and hyperlinks to in-depth annotated notes and alternative text. Often, the judges either didn't or wouldn't recognize these innovations.
The upshot was that 80 percent of the finalists were digital editions of hardcover books from mainstream publishers written by big-name authors. For example, Steven Levy's Crypto (Penguin Putnam) and Amitav Ghosh's The Glass Palace (Random House) were the 2001 grand prize winners.
Problems plagued the awards from the outset. The show got off to a rocky start when many e-publishing companies were ineligible to enter due to requirements that they publish more than 20 titles a year -- which was another blow to the presumed concept of celebrating something new. Protest led to those rules being relaxed, but the damage had been done and many independent publishers boycotted the awards.
"They lost my interest and my support as an e-author (and my publisher's support)," said Pauline B. Jones, whose The Last Enemy was the first e-book to win a Reviewer's Choice award from Romantic Times Magazine. "In my opinion it was just another way for the 'big boys' to ensure the continued survival of the dinosaur of big publishing."
Ed Scorb, one of only two Frankfurt winners not published by a large house, said he was grateful for the $50,000 he won in 2000 for his novel, Paradise Square. But he said the foundation reneged on help it had offered to get the book placed with a larger house.
"It was a terrible experience," Scorb said. "One would think that those involved would have gotten behind the prize-winning book. None did. It's said that the rich, powerful and famous will drop you in five seconds. I can attest to the fact."
E-book awards anew: The good news for the industry is that Microsoft isn't giving up on its support for e-books.
On the heels of pulling funding from the IeBAF, Microsoft announced the launch of the International eBook Association (IeBA), a new e-book organization based in Europe that will work to address critical issues facing the electronic publishing community. Its principal goal will be to facilitate and accelerate the adoption of e-books.
A new set of e-book awards sponsored by the IeBA will be announced shortly.
"As the e-books industry evolves past its first critical years, the need for large monetary awards to attract interest and attention has been replaced by the need to address commercial and technological issues," said Dick Brass, vice president of technology development at Microsoft.
Many publishers will be watching to see what this news means. "The Frankfurt eBook Awards provided needed publicity for the e-book industry, and that was a very good thing," Scott Pendergrast, co-founder of Fictionwise, said.
Got guilt? Author Emma Kaufmann wants to know what you're guilty about and invites you to unload it at her "Guilt Dump" and to enter the "Got Guilt?" contest, which runs until May 12.
It's all part of the promotion the author is doing to introduce Guilt -- a psychological thriller about several characters suffering from, you guessed it. And as far as promotions for novels go, this one seems to be pressing a lot of buttons. Kaufmann is receiving hundreds of entries a day.
"I feel guilty for writing this when I should be studying the World's Most Boring Geology Text for my exam next week," wrote one entrant.
"I feel guilty for reading about the Meg Ryan-Dennis Quaid divorce, because it's none of my business and a waste of my time," wrote another.
Not all the entries are humorous. One war veteran wrote about missing a plane to Khe Sanh, Vietnam, during the 1971 campaign. He was supposed to replace a soldier who was returning home, but because he was a day late, the soldier had to stay one more night.
"My guilt is deep-seated and long-lasting," he wrote. "That night, the enemy attacked and the tank he was on, the one I was suppose to be on, was hit with a rocket-propelled grenade. All on board were killed, and the tank reduced to a burnt-out cinder. When I saw that the next day upon my arrival, I was devastated."
Kaufmann said she is surprised how many people seem to find relief from sending in their guilt trips and thank her for letting them get it off their chest. She hopes in the process they decide to buy her novel.
Even if it is out of guilt.
Lively discussion award: The 2002 BookMuse Awards, for books that stimulate exceptionally lively and satisfying reading group discussions, were announced.
The Feast of Love, by Charles Baxter, and The Hunter, by Julia Leigh, were the two winners in the adult category. The two kids' winners are The Ink Drinker, by Eric Sanvoisin and illustrated by Martin Matje (younger reader category), and Speak, by Laurie Halse Anderson (older reader category).
The idea behind the awards is that many great books can be reading-group flops while less-famous works can be discussion gems, Kristine Ball, BookMuse founder and CEO, said. Winners are chosen by editors and writers who have been leading reading groups for years.
To be eligible, fiction titles must have been in paperback for a year or less and have been featured on the BookMuse.com website.
"The adult book award winners ask unanswerable questions, their characters are multidimensional, and their plots are at once contained and complex," Ball said. "And the kids' winners are unpredictable and provocative in some singular way. With these ingredients great discussions are all but guaranteed."
Color me self-published: Photographs and illustrations are no longer a black-and-white issue in print-on-demand publishing: Xlibris is the first POD publisher to offer color digital publishing.
The Xlibris Picture Book is available in a range of formats, allowing authors to customize the exact book they envision. The books take a few months to produce and can be between 24 and 60 pages in length. Production setup fees cost from $999 to $2,499.
The new technology was developed in conjunction with Berryville Graphics, a book manufacturer in the United States.
"This is a major step for publishing," said Xlibris CEO John Feldcamp. "The ability to publish full-color books on demand changes the landscape of publishing and makes the market accessible to a whole new group of authors."
M.J. Rose's new novel, Flesh Tones, will be published this summer.


text:
The domain within your query sequence starts at position 1585 and ends at position 1620; the E-value for the PBD domain shown below is 7.16e-10.
ISNPTNFNHVAHMGPGDGMQVLMDLPLSAAPTVQEE
PBD
P21-Rho-binding domain
Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also known as the Cdc42/Rac interactive binding (CRIB).
This entry represents the CRIB domain.
Many putative downstream effectors of the small GTPases Cdc42 and Rac contain a GTPase binding domain (GBD), also called p21 binding domain (PBD), which has been shown to specifically bind the GTP bound form of Cdc42 or Rac, with a preference for Cdc42 [ (PUBMED:8107774) (PUBMED:8625410) ]. The most conserved region of GBD/PBD domains is the N-terminal Cdc42/Rac interactive binding motif (CRIB), which consists of about 16 amino acids with the consensus sequence I-S-x-P-x(2,4)-F-x-H-x(2)-H-V-G [ (PUBMED:7493928) ].
Although the CRIB motif is necessary for the binding to Cdc42 and Rac, it is not sufficient to give high-affinity binding [ (PUBMED:9660763) (PUBMED:9601050) ]. A less well conserved inhibitory switch (IS) domain responsible for maintaining the proteins in a basal (autoinhibited) state is located C-terminaly of the CRIB-motif [ (PUBMED:10724160) (PUBMED:10975528) (PUBMED:10966102) ].
GBD domains can adopt related but distinct folds depending on context. Although GBD domains are largely unstructured in the free state, the IS domain forms an N-terminal beta-hairpin that immediately follows the conserved CRIB motif and a central bundle of three alpha-helices in the autoinhibited state. The interaction between GBD domains and their respective G proteins leads to the formation of a high-affinity complex in which unstructured regions of both the effector and the G protein become rigid. CRIB motifs from various GBD domains interact with Cdc42 in a similar manner, forming an intermolecular beta-sheet with strand beta-2 of Cdc42. Outside the CRIB motif, the C-terminal of the various GBD domains are very divergent and show variation in their mode of binding to Cdc42, perhaps determining the specificity of the interaction. Binding of Cdc42 or Rac to the GBD domain causes a dramatic conformational change, refolding part of the IS domain and unfolding the rest [ (PUBMED:9660763) (PUBMED:10724160) (PUBMED:10975528) (PUBMED:10966102) (PUBMED:10360579) ].
Some proteins known to contain a CRIB domain are listed below:
Mammalian activated Cdc42-associated kinases (ACKs), nonreceptor tyrosine kinases implicated in integrin-coupled pathways.
Mammalian p21-activated kinases (PAK1 to PAK4), serine/threonine kinases that modulate cytoskeletal assembly and activate MAP-kinase pathways.
Mammalian Wiskott-Aldrich Symdrom Proteins (WASPs), non-kinase proteins involved in the organisation of the actin cytoskeleton.
Yeast STE20 and CLA4, the homologues of mammalian PAKs. STE20 is involved in the mating/pheromone MAP kinase cascade.
There are 9112 PBD domains in 8652 proteins in SMART's nrdb database.
Taxonomic distribution of proteins containing PBD domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with PBD domain is also avaliable.
Click on the protein counts, or double click on taxonomic names to display all proteins containing PBD domain in the selected taxonomic class.
Cellular role (predicted cellular role)
Cellular role: signalling
Binding / catalysis: Cdc42p-binding, Rho-GTPase-binding
Nimnual AS, Yatsula BA, Bar-Sagi D
Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos.
Science. 1998; 279: 560-3
The Son of Sevenless (Sos) proteins control receptor-mediated activation of Ras by catalyzing the exchange of guanosine diphosphate for guanosine triphosphate on Ras. The NH2-terminal region of Sos contains a Dbl homology (DH) domain in tandem with a pleckstrin homology (PH) domain. In COS-1 cells, the DH domain of Sos stimulated guanine nucleotide exchange on Rac but not Cdc42 in vitro and in vivo. The tandem DH-PH domain of Sos (DH-PH-Sos) was defective in Rac activation but regained Rac stimulating activity when it was coexpressed with activated Ras. Ras-mediated activation of DH-PH-Sos did not require activation of mitogen-activated protein kinase but it was dependent on activation of phosphoinositide 3-kinase. These results reveal a potential mechanism for coupling of Ras and Rac signaling pathways.
Thompson G, Owen D, Chalk PA, Lowe PN
Delineation of the Cdc42/Rac-binding domain of p21-activated kinase.
Biochemistry. 1998; 37: 7885-91
p21-activated kinases (PAKs) serve as effector proteins for the GTP-binding proteins Cdc42 and Rac. They are serine/threonine kinases containing the Cdc42/Rac interactive binding (CRIB) motif. The main aim of this study was to define the minimal domain of alphaPAK required for Cdc42/Rac binding. Eight stable PAK fragments of varying lengths, each containing the CRIB motif (residues 75-88), were expressed in Escherichia coli, and their ability to interact with Cdc42 and Rac was assessed using scintillation proximity assays, isothermal titration calorimetry, and fluorescence techniques. The shortest fragments examined (residues 70-94 and 75-94) bound only weakly to either Cdc42 or Rac. A longer fragment starting at residue 75 and ending at residue 105 showed binding to Q61L Rac.GTP with Kd = 1.9 microM. Highest affinity binding (Kd approximately 0.05 microM) was seen with longer fragments ending at residue 118 or 132. A small increase in affinity was seen with those fragments starting at residue 70 rather than residue 75. PAK fragments bound with approximately 3-10-fold higher affinity to Cdc42 than to Rac and bound Q61L variants with 5-10-fold higher affinity than wild type. The dissociation rates of Q61L Rac.mant-GTP and of Q61L Cdc42. mant-GTP from PAK fragment residues 70-132 were measured to be 0.66 and 0.25 min-1, respectively, which are 100-fold lower than dissociation rates for Ras:Ras-effector domains, although their affinities are similar. Calorimetric measurements revealed that binding was associated with a relatively slow heat change. It is suggested that these PAK fragments (in the absence of Cdc42 or Rac) might exist predominantly in an inactive conformation that slowly interconverts with an active conformation and/or a slow conformational change may occur upon binding to Cdc42/Rac. In conclusion, the PAK CRIB motif itself is insufficient for high-affinity binding to Cdc42/Rac, but a 30 amino acid region of PAK (residues 75-105), containing this motif, is sufficient.
Aspenstrom P
A Cdc42 target protein with homology to the non-kinase domain of FER has a potential role in regulating the actin cytoskeleton.
Curr Biol. 1997; 7: 479-87
BACKGROUND: Members of the Rho family of small GTPases have been shown to have a diverse role in cell signalling events. They were originally identified as proteins that, by regulating the assembly of the actin cytoskeleton, are important determinants of cell morphology, and have recently been shown to be involved in transcriptional activation by the JNK/SAPK signalling pathway. In order to understand the mechanisms underlying the effects of Rho GTPases on these processes, the yeast two-hybrid system has been used to identify proteins that bind to an activated mutant of Cdc42, a Rho-family member. RESULTS: A cDNA encoding a previously unidentified Cdc42 target protein, CIP4, which is 545 amino-acids long and contains an SH3 domain at its carboxyl terminus, was cloned from a human B-cell library. The amino terminus of CIP4 bears resemblance to the non-kinase domain of the FER and Fes/Fps family of tyrosine kinases. In addition, similarities to a number of proteins with roles in regulating the actin cytoskeleton were noticed. CIP4 binds to activated Cdc42 in vitro and in vivo and overexpression of CIP4 in Swiss 3T3 fibroblasts reduces the amount of stress fibres in these cells. Moreover, coexpression of activated Cdc42 and CIP4 leads to clustering of CIP4 to a large number of foci at the dorsal side of the cells. CONCLUSIONS: CIP4 is a downstream target of activated GTP-bound Cdc42, and is similar in sequence to proteins involved in signalling and cytoskeletal control. Together, these findings suggest that CIP4 may act as a link between Cdc42 signalling and regulation of the actin cytoskeleton.
Feltham JL et al.
Definition of the switch surface in the solution structure of Cdc42Hs.
Proteins of the rho subfamily of ras GTPases have been shown to be crucial components of pathways leading to cell growth and the establishment of cell polarity and mobility. Presented here is the solution structure of one such protein, Cdc42Hs, which provides insight into the structural basis for specificity of interactions between this protein and its effector and regulatory proteins. Standard heteronuclear NMR methods were used to assign the protein, and approximately 2100 distance and dihedral angle constraints were used to calculate a set of 20 structures using a combination of distance geometry and simulated annealing refinement. These structures show overall similarity to those of other GTP-binding proteins, with some exceptions. The regions corresponding to switch I and switch II in H-ras are disordered, and no evidence was found for an alpha-helix in switch II. The 13-residue insertion, which is only present in rho-subtype proteins and has been shown to be an important mediator of binding of regulatory and target proteins, forms a compact structure containing a short helix lying adjacent to the beta4-alpha3 loop. The insert forms one edge of a "switch surface" and, unexpectedly, does not change conformation upon activation of the protein by the exchange of GTP analogs for GDP. These studies indicate the insert region forms a stable invariant "footrest" for docking of regulatory and effector proteins.
Leberer E, Wu C, Leeuw T, Fourest-Lieuvin A, Segall JE, Thomas DY
Functional characterization of the Cdc42p binding domain of yeast Ste20p protein kinase.
EMBO J. 1997; 16: 83-97
Ste20p from Saccharomyces cerevisiae belongs to the Ste20p/p65PAK family of protein kinases which are highly conserved from yeast to man and regulate conserved mitogen-activated protein kinase pathways. Ste20p fulfills multiple roles in pheromone signaling, morphological switching and vegetative growth and binds Cdc42p, a Rho-like small GTP binding protein required for polarized morphogenesis. We have analyzed the functional consequences of mutations that prevent binding of Cdc42p to Ste20p. The complete amino-terminal, non-catalytic half of Ste20p, including the conserved Cdc42p binding domain, was dispensable for heterotrimeric G-protein-mediated pheromone signaling. However, the Cdc42p binding domain was necessary for filamentous growth in response to nitrogen starvation and for an essential function that Ste20p shares with its isoform Cla4p during vegetative growth. Moreover, the Cdc42p binding domain was required for cell-cell adhesion during conjugation. Subcellular localization of wild-type and mutant Ste20p fused to green fluorescent protein showed that the Cdc42p binding domain is needed to direct localization of Ste20p to regions of polarized growth. These results suggest that Ste20p is regulated in different developmental pathways by different mechanisms which involve heterotrimeric and small GTP binding proteins.
Osada S, Izawa M, Koyama T, Hirai S, Ohno S
A domain containing the Cdc42/Rac interactive binding (CRIB) region of p65PAK inhibits transcriptional activation and cell transformation mediated by the Ras-Rac pathway.
FEBS Lett. 1997; 404: 227-33
The molecular bases of the versatile functions of Rho-like GTPases are still unknown. Using luciferase assays with rat 3Y1 cells, we found that Rac1 is integrated downstream of Ras in the TRE (TPA response element) activation pathway. Coexpression of a mutant of p65PAK, PAK/RD, lacking the kinase domain but containing the Cdc42/Rac interactive binding (CRIB) region, suppressed the TRE activation and cell transformation caused by constitutively activated forms of Ras (RasV12) and Rac1 (Rac1V12). PAK/RD is a good tool to investigate the signaling pathways in which Rac and Cdc42 are involved.
Rittinger K et al.
Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP.
Nature. 1997; 388: 693-7
Small G proteins transduce signals from plasma-membrane receptors to control a wide range of cellular functions. These proteins are clustered into distinct families but all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of G proteins, which includes Cdc42Hs, activate effectors involved in the regulation of cytoskeleton formation, cell proliferation and the JNK signalling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GTPase-activating proteins (GAPs) that enhance the rate of GTP hydrolysis by up to 10(5) times. We report here the crystal structure of Cdc42Hs, with the non-hydrolysable GTP analogue GMPPNP, in complex with the GAP domain of p50rhoGAP at 2.7A resolution. In the complex Cdc42Hs interacts, mainly through its switch I and II regions, with a shallow pocket on rhoGAP which is lined with conserved residues. Arg 85 of rhoGAP interacts with the P-loop of Cdc42Hs, but from biochemical data and by analogy with the G-protein subunit G(i alpha1), we propose that it adopts a different conformation during the catalytic cycle which enables it to stabilize the transition state of the GTP-hydrolysis reaction.
Zhang B, Wang ZX, Zheng Y
Characterization of the interactions between the small GTPase Cdc42 and its GTPase-activating proteins and putative effectors. Comparison of kinetic properties of Cdc42 binding to the Cdc42-interactive domains.
J Biol Chem. 1997; 272: 21999-2007
The small GTPase Cdc42 interacts with multiple factors to transduce diverse intracellular signals. The factors that preferentially recognize the GTP-bound, active state of Cdc42 include a panel of GTPase-activating proteins (GAPs), the Cdc42/Rac interactive binding (CRIB) motif-containing molecules, and the RasGAP domain containing IQGAP1 and IQGAP2. In the present study, we have determined the kinetic parameters underlying the functional interactions between the Cdc42-binding domains of some of these factors and Cdc42 by monitoring the continuous release of gammaPi and have compared the ability of the domains to bind to Cdc42. The catalytic efficiencies (Kcat/Km) of the GAP domains of Bcr, 3BP-1, and p190 on Cdc42 are found to be 60-, 160-, and over 500-fold less than that of Cdc42GAP, respectively, and the differences are due, to a large part, to differences in Km. The Km values of the GAP domains compare well to the binding affinity to the guanylyl imidodiphosphate-bound Cdc42, suggesting a rapid equilibrium reaction mechanism. The affinity of the Cdc42-binding domains of the CRIB motif of Wiskott-Aldrich Syndrome protein and p21(cdc42/rac)-activated kinase 1, and the RasGAP-related domain of IQGAP1, which all inhibit the intrinsic rate of GTP hydrolysis of Cdc42, are found to be 4, 0.7, and 0.08 microM, respectively. These quantitative analysis provide insight that Cdc42GAP functions as an effective negative regulator of Cdc42 by fast, relatively tight binding to the GTP-bound Cdc42, whereas IQGAP1 interacts with Cdc42 as a putative effector with over 10-fold higher affinity than the CRIB domains and GAPs, and suggest that various GAPs and effectors employ distinct mechanism to play roles in Cdc42-mediated signaling pathways.
Hart MJ, Callow MG, Souza B, Polakis P
IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs.
Proteins that associate with the GTP-bound forms of the Ras superfamily of proteins are potential effector targets for these molecular switches. A 195 kDa protein was purified from cell lysates by affinity chromatography on immobilized cdc42Hs-GTP and a corresponding cDNA was isolated. Sequence analysis revealed localized identities to calponin, the WW domain, unconventional myosins and to the rasGAP-related domain (GRD) contained in IRA, NF-1, SAR1 and rasGAP. p195 was found to be identical to IQGAP1, a protein previously reported to bind ras. Purified recombinant p195/IQGAP1 bound to and inhibited the GTPase activity of cdc42Hs and rac whereas no interaction with ras was detected. The C-terminal half of IQGAP1 containing the GRD bound to cdc42 and rac in a GRD-dependent fashion, but a smaller fragment containing only the GRD did not. Cdc42 was also co-immunoprecipitated from cell lysates with antibody specific to p195/IQGAP1. Calmodulin also co-immunoprecipitated with p195/IQGAP1 and was found to associate with fragments containing the IQ domain. Expression of a cDNA fragment encoding the GRD inhibited the CDC24/CDC42 pathway in yeast, but no effect on ras was observed. In mammalian cells, both endogenous and ectopically expressed p195/IQGAP1 were localized to lamellipodia and ruffling cell membranes, where co-localization with actin was apparent. These results suggest that IQGAP1 is an effector target for cdc42Hs and may mediate the effects of this GTPase on cell morphology.
Symons M et al.
Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization.
Cell. 1996; 84: 723-34
The Rho family of GTPases control diverse biological processes, including cell morphology and mitogenesis. We have identified WASP, the protein that is defective in Wiskott-Aldrich syndrome (WAS), as a novel effector for CDC42Hs, but not for the other Rho family members, Rac and Rho. This interaction is dependent on the presence of the G protein-binding domain. Cellular expression of epitope-tagged WASP produces clusters of WASP that are highly enriched in polymerized actin. This clustering is not observed with a C-terminally deleted WASP and is inhibited by coexpression with dominant negative CDC42Hs-N17, but not with dominant negative forms of Rac or Rho. Thus, WASP provides a novel link between CDC42Hs and the actin cytoskeleton, which suggests a molecular mechanism for many of the cellular abnormalities in WAS. The WASP sequence contains two novel domains that are homologous to other proteins involved in action organization.
Burbelo PD, Drechsel D, Hall A
A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases.
J Biol Chem. 1995; 270: 29071-4
Rho, Rac, and Cdc42 are small GTPases that regulate the formation of a variety of actin structures and the assembly of associated integrin complexes, but little is known about the target proteins that mediate their effects. Here we have used a motif-based search method to identify putative effector proteins for Rac and Cdc42. A search of the GenBankTM data base for similarity with the minimum Cdc42/Rac interactive binding (CRIB) region of a potential effector protein p65PAK has identified over 25 proteins containing a similar motif from a range of different species. These candidate Cdc42/Rac-binding proteins include family members of the mixed lineage kinases (MLK), a novel tyrosine kinase from Drosophila melanogaster (DPR2), a human protein MSE55, and several novel yeast and Caenorhabditis elegans proteins. Two murine p65PAK isoforms and a candidate protein from C. elegans, F09F7.5, interact strongly with the GTP form of both Cdc42 and Rac, but not Rho in a filter binding assay. Three additional candidate proteins, DPR2, MSE55, and MLK3 showed binding to the GTP form of Cdc42 and weaker binding with Rac, and again no interaction with Rho. These results indicate that proteins containing the CRIB motif bind to Cdc42 and/or Rac in a GTP-dependent manner, and they may, therefore, participate in downstream signaling.
Madaule P et al.
A novel partner for the GTP-bound forms of rho and rac.
FEBS Lett. 1995; 377: 243-8
Using the yeast two hybrid system and overlay assays we identified a putative rholrac effector, citron, which interacts with the GTP-bound forms of rho and rac1, but not with cdc42. Extensive homologies to known proteins were not observed. This 183 kDa protein contains a C6H2 zinc finger, a PH domain, and a long coiled-coil forming region including 4 leucine zippers and the rholrac binding site. We recently identified three others putative rho effectors characterized by a common rho binding motif. Citron does not share this motif and displays a distinctive protein organization, thus defining a separate class of rho partners.
Ottilie S et al.
Fission yeast pak1+ encodes a protein kinase that interacts with Cdc42p and is involved in the control of cell polarity and mating.
EMBO J. 1995; 14: 5908-19
A STE20/p65pak homolog was isolated from fission yeast by PCR. The pak1+ gene encodes a 72 kDa protein containing a putative p21-binding domain near its amino-terminus and a serine/threonine kinase domain near its carboxyl-terminus. The Pak1 protein autophosphorylates on serine residues and preferentially binds to activated Cdc42p both in vitro and in vivo. This binding is mediated through the p21 binding domain on Pak1p and the effector domain on Cdc42p. Overexpression of an inactive mutant form of pak1 gives rise to cells with markedly abnormal shape with mislocalized actin staining. Pak1 overexpression does not, however, suppress lethality associated with cdc42-null cells or the morphologic defeat caused by overexpression of mutant cdc42 alleles. Gene disruption of pak1+ establishes that, like cdc42+, pak1+ function is required for cell viability. In budding yeast, pak1+ expression restores mating function to STE20-null cells and, in fission yeast, overexpression of an inactive form of Pak inhibits mating. These results indicate that the Pak1 protein is likely to be an effector for Cdc42p or a related GTPase, and suggest that Pak1p is involved in the maintenance of cell polarity and in mating.
16.47 map04810 Regulation of actin cytoskeleton
12.99 map04012 ErbB signaling pathway
12.99 map04660 T cell receptor signaling pathway
12.99 map05211 Renal cell carcinoma
12.99 map04510 Focal adhesion
12.99 map04360 Axon guidance
4.18 map05120 Epithelial cell signaling in Helicobacter pylori infection
4.18 map04650 Natural killer cell mediated cytotoxicity
0.23 map00562 Inositol phosphate metabolism
This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with PBD domain which could be assigned to a KEGG orthologous group, and not all proteins containing PBD domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.
3D Structures of PBD domains in PDB
1cee SOLUTION STRUCTURE OF CDC42 IN COMPLEX WITH THE GTPASE BINDING DOMAIN OF WASP
1e0a Cdc42 complexed with the GTPase binding domain of p21 activated kinase
1ees SOLUTION STRUCTURE OF CDC42HS COMPLEXED WITH A PEPTIDE DERIVED FROM P-21 ACTIVATED KINASE, NMR, 20 STRUCTURES
1ej5 SOLUTION STRUCTURE OF THE AUTOINHIBITED CONFORMATION OF WASP
1f3m CRYSTAL STRUCTURE OF HUMAN SERINE/THREONINE KINASE PAK1
1t84 Solution structure of the Wiskott-Aldrich Syndrome Protein (WASP) autoinhibited core domain complexed with (S)-wiskostatin, a small molecule inhibitor
2k42 Solution Structure of the GTPase Binding Domain of WASP in Complex with EspFU, an EHEC Effector
2lnh Enterohaemorrhagic E. coli (EHEC) exploits a tryptophan switch to hijack host F-actin assembly
2odb The crystal structure of human cdc42 in complex with the CRIB domain of human p21-activated kinase 6 (PAK6)
2ov2 The crystal structure of the human RAC3 in complex with the CRIB domain of human p21-activated kinase 4 (PAK4)
2qme Crystal structure of human RAC3 in complex with CRIB domain of human p21-activated kinase 1 (PAK1)
4fie Full-length human PAK4
4mit 4MIT


text:
Palmarès

Olimpiadi
1 medaglia:
1 argento (inseguimento a squadre a )

Mondiali distanza singola
 2 medaglie:
 2 bronzi (5000 m e inseguimento a squadre a Heerenveen 2021).

Note

Altri progetti

Collegamenti esterni

redpajama_set_name: RedPajamaWikipedia


The economic capital of Israel is full of trendy bars and excellent food places. For shopping, it's more difficult. Most of the Western brands have their store in newly renovated/built shopping malls, but you may find some interesting stores in the streets too. Short Story is one of them. This concept store combines fashion (for men and women) with beautiful interior design items and a whole basement of shoes. As I'm going to move to the centre of Antwerp, I was very interested about the interior items. I walked out with some fancy golden paper clips in my hand, because this will be one of the main colours of the living room. More about this you can read here, on Matthias' blog.


text:
Crystal Hefner Says She's 'Removed Everything Fake' from Her Body and Purged Her Social Media
Crystal Hefner Says She's 'Removed Everything Fake' from Her Body and Purged Her Social Media.. Hugh Hefner's widow Crystal is opening up about a big transition in her life.
The 35-year-old revealed on Instagram that she "removed everything fake from my body and deleted all my old photos," as she embraces a more modest lifestyle.
Crystal explained, "After the last handful of years staying true to myself on social media, I feel that all the people here with me at this point actually care and are invested in my life in a positive way and for that I thank you."
She spent the past five years transitioning her Instagram from "not always safe for work posts" to her "REAL safe for work life."
A post shared by Crystal Hefner (@crystalhefner)
Crystal says her account now represents "the real me," adding, "I was living for other people before, to make others happy, suffering internally in the process."
READ ALSO; Nigerian Idol: Comfort exit stirs reactions as Akunna, Emmanuel & Kingdom emerge top 3
Looking back at her Playboy years, she isn't sure if she felt empowered or the pressure of expectation to post pictures while "dressing scantily clad, showing cleavage, etc." Regardless, Crystal says, "I can confidently and 100% proudly say, modesty is what empowers me these days, and because it feels so much better internally, it will probably be this way for the rest of my life."
As she moved away from her sexier image, Hefner said, "I saw followers drop by the thousands every day… But now it has shifted… Most days the count is growing. Now my women followers are giving the men followers a run for their money. Now I truly feel I have an army of supporters that care and see an actual soul behind the lens. For that I thank you."
READ ALSO; Paul Rudd Welcomed by Tom Hanks and Tina Fey to the Five-Timers Club During 'SNL' Monologue
Moving forward, she says, "I will make it my mission to try and help in all ways that I can while staying true to myself. I hope all of you can stay true to yourself and to what feels right for you as well, because there's a certain power you get from that you can't find anywhere else. I love you."
Crystal, who was the Playboy Playmate of the month in December 2009, was married to Hugh from 2012 until his death in 2017.
READ ALSO; Rapper Lil Mosey, charged with rape, wanted by police
Tags: celebrity, Crystal Hefner
Speeding, erratic driving led to Geno Smith DUI arrest
Fauci fires back at Rand Paul, accusing him of using attacks for 'political gain'


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Nationally recognized mental health and suicide prevention program coming to IU Southeast
NEW ALBANY, Ind. – Indiana University Southeast Counseling Services has received a $7,500 grant from the Horseshoe Foundation of Floyd County to bring a nationally recognized mental health and suicide prevention event to the IU Southeast campus in the fall of 2018.
"Send Silence Packing" is a public exhibit with the goal of raising awareness of the incidence and impact of suicide, connecting students to needed resources, and bolstering suicide prevention efforts on college campuses.
The exhibit features 1,000 backpacks that represent the more than 1,100 college students who die by suicide each year. Attached to each backpack is a personal story of a college student who has lost his or her life to suicide.
A "Send Silence Packing" exhibit featuring 1,000 backpacks that represent the more than 1,100 college students who die by suicide each year
"'Send Silence Packing' will help us increase understanding of mental health issues and and raise awareness for suicide prevention on our campus and in our community," said Beth Rueschhoff, associate professor of biology at IU Southeast and co-organizer of campus mental health events. "We hope to decrease stigma and create an open dialogue on mental health and wellness."
The exhibit is sponsored by Active Minds, a national nonprofit dedicated to young adult mental health advocacy and awareness. Active Minds is student-driven, with 400 student-led chapters working with parents, families and school administrators to change the conversation on mental health and suicide prevention on college campuses.
"By displaying backpacks with personal stories, Send Silence Packing puts a 'face' to lives lost to suicide and carries the message that preventing suicide is not just about improving statistics, but also about saving the lives of daughters, sons, brothers, sisters and friends across the nation," the organization notes on its website.
Active Minds will have trained staff on hand all day at the IU Southeast event to answer questions and provide resources for students, and a follow-up discussion will be held to allow participants to process and reflect on the experience.
Displayed for the first time in 2008 on the National Mall, "Send Silence Packing" has since traveled to more than 140 cities. It will come to IU Southeast as part of the campus's interdisciplinary Mental Health and Wellness Seminar Series, a series of lectures, discussions, films and events designed to promote dialogue about mental health and provide support and information to those suffering from and affected by mental illness, especially those who may not be comfortable seeking help or may not know where to turn. Past seminars have resulted in 96% of attendees stating that they were more likely to openly discuss the mental health topic covered with family, friends and/or peers following the event.
Over the past three years, a wide range of topics has been covered in the series, including Post Traumatic Stress Disorder (PTSD), heroin and opiate addiction, costs of mental illness for the business community, challenges of mental health management in disenfranchised populations (such as those who are incarcerated), managing stress and anxiety, the biology of mental illness and maintaining mental health while caregiving. The series also presents activities for Suicide Prevention Week, including depression screenings, a resource fair and the Out of the Darkness Community Walk.
The Horseshoe Foundation of Floyd County is a private foundation created to benefit the Floyd County community. The Foundation's philanthropic focus falls into the categories of grant making to charitable non-profit organizations, educational scholarships and program-related investments that encourage economic development. Since its founding, the Horseshoe Foundation of Floyd County has given more than $42 million to the Floyd County Community.
Indiana University Southeast is one of seven campuses of Indiana University. Offering more than 100 degree programs and concentrations, the scenic 180-acre campus is located less than 15 minutes from downtown Louisville, Kentucky. As a public comprehensive university, IU Southeast prepares graduates for productive citizenship in a diverse society, and it contributes to the intellectual, cultural, civic and economic development of the region. It currently has an enrollment of more than 6,000 students and employs more than 400 faculty members. About 400 students now live on campus in five fully furnished, lodge-style residence halls. For more information, visit www.ius.edu. IU Southeast is a tobacco-free campus.
TAGS: advancement, caesars foundation, development, grants, homepage, Office of Advancement, personal counseling


Thanks bro for buying my item ! Til our next deal. HIGHLY RECOMMENDED MEMBER!
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Thank you for buying my item..
Don't hesitate to transact with ungaster..
RE: iPhone 4s 16GB Smart Locked (WHITE) --> Great buyer, had a fast and easy transaction with him! Til next time! Thanks!
smooth and hassle free deal!
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very smooth and hassle free deal.
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Madali ka deal at walang paikot-ikot.
Thanks for buying my phone.


By Washington State law, the act of inspecting for pests, their signs, or conducive conditions requires one to be licensed by the WSDA. In addition, structural pest inspectors must be bonded or insured and must use WSDA-issued Inspection Control Numbers.
All wood destroying organism (WDO) reports that are prepared in conjunction with the transfer, exchange or refinance of any structure must have an inspection control number (ICN) recorded on them.
The Association of Structural Pest Control Regulatory Officials is a professional association comprised of the structural pest control regulatory officials of any of the fifty states.
**Adobe PDF documents require Adobe Acrobat Reader.


text:
Rationalisierung steht für:

 Rationalisierung (Soziologie)
 Rationalisierung (Ökonomie)
 Rationalisierung (Psychologie)
 Rationalisierung (Bruchrechnung)
 Rationalisierung (Gesundheitswesen)
 Post-purchase rationalisation

Siehe auch:


text:
El Museo de las Mujeres () de Dallas fue un museo dedicado a la vida y la historia de las mujeres de Estados Unidos activo de 2000 a 2011.

El museo se ubicaba en el Parque de la Feria, el lugar donde se realiza la Feria de Texas y que acoge a otros museos y pabellones. Estaba conectado al Instituto Smithsoniano.

En 1996 Cathy Bonner expuso la idea de la creación de un museo que recogiera y difundiera la historia de la mujer en Estados Unidos. El proyecto fue asignado a Wendy Evans Joseph, arquitecta que cuenta entre sus obras con el Museo del Holocausto de Washington D.C.

Se inauguró el 29 de septiembre del año 2000. El 5 de octubre del 2011 se anunció el cierre del museo el 31 de octubre del 2011 debido a problemas financieros.

Sus archivos fueron trasladados a la Universidad de la Mujer de Texas en Denton.

Referencias

Enlaces externos
 Página web del museo

Museos de Dallas/Fort Worth
Museos monográficos de Estados Unidos
Museos de Estados Unidos del siglo XXI
Museos inaugurados en 2000
Museos de mujeres


Lydia is a trainee Solicitor currently sitting in the Planning team.
She obtained a first-class honours degree in Human Geography (BA) from the University of Exeter. She then achieved distinctions in both her GDL and LPC (LLM) from the University of Law in Guildford.
Outside of work, Lydia enjoys cooking and she has run several half-marathons raising money for charities including Guide Dogs UK and Cancer Research.


The Attorney General's Department annual report to be presented to parliament reveals that there are over 17 thousand 600 unsettled cases in connection with child abuse has been filed up in the department.
161 convicts of child abuse were imprisoned in 2017 and, it was the least amount of cases reported after 2015.
Among these cases are child sexual abuse, using children for begging and drug peddling.
A senior officer of the Department stated despite measures have been taken to settle these cases, there are several other reasons which cause the delay to settle them.
He said one of the major issues is incomplete details to file action.
Most of the victims are under the age of 16 and, the majority is reluctant to testify before courts.


Have we reached fintech fatigue?
The Commonwealth Bank of Australia (CBA) has overtaken Australia New Zealand Banking Group (ANZ) to become the most valuable brand in banking, according to a survey of Australia's most valuable brands.
Despite issues around trust and scandals confronting the industry, all the major banks ranked in the top ten of the survey by global consultant Brand Finance, with CBA in the number two spot overall behind Telstra.
The findings revealed a nine per cent increase in brand value helped CBA reclaim its position as Australia's most valuable banking brand.
ANZ and National Australia Bank ranked third and fourth respectively, while Westpac experienced the greatest drop, falling from fifth position in 2016 to seventh place overall in 2017. Fifty per cent of the top 10 brands in Australia are banks with the millionaires' factory Macquarie Bank taking tenth spot.
The findings are part of the Brand Finance Global 500 and Australia 100 surveys, which rank brands by monetary value and calculate the most 'powerful' brands, as defined by the companies whose enterprise value is most positively impacted by the strength of the brand. The total value of the 100 most valuable Australian brands is nearly $143 billion.
The survey highlighted the resilience of banks in a time of increased public scrutiny on the way banks have managed their businesses. This has already culminated in an annual parliamentary review into the major banks and a number of industry reviews.
However, public perceptions around bank conduct could eventually have an impact on the banks, according to Brand Finance managing director Mark Crowe.
"The major bank brands have demonstrated significant resilience in recent times. However, it should be noted this year that all the major banks with the exception of NAB have experienced a decline in brand strength," Crowe told AB+F.
"If the decline is not arrested this will invariably put significant pressure on brand value over the next year."
He said the challenge for Australian banks is how to leverage brand strength in terms of market expansion overseas and/or extension into other industries.
The Trump presidency will also effect Australia's banks but, according to the survey, his presidency could provide an opportunity for the sector.
Looking at the international research, financial services companies made up 20 per cent of the Global 500 survey in 2017. The brand value of Wells Fargo fell 6 per cent after a turbulent year for the bank, with the Industrial and Commercial Bank of China replacing it as the most valuable financial brand in the world. However, Wells Fargo retains its position as the most valuable banking brand in the United States.
Payment service providers Visa and Mastercard's brand value grew by 81 per cent and 58 per cent respectively as consumers move to an increasingly cashless society and become reliant on the two companies' services.


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Simple Minds – Sons and Fascination / Sister Feelings Call
40 years ago today, Simple Minds released two albums simultaneously. These albums were a turning point, consolidating the progress they had made on their first three albums. Both albums came with growing sense of ambition, purpose, confidence. Empires & Dance had seen a sea change in Jim Kerr's lyrics, a shift to a more stream of conscious style, rather than trying to tell stories. On both Sons & Fascination and its sibling, Sister Feelings Call, this all came together into a coherent piece of art – cryptic, strange, arch, arty, rock, funky, shouty, haunting, BIG! The rhythm section was loud and upfront, way more prominent than on previous albums, making this new music propulsive, mesmerising.
Sister Feelings Call was released as a free bonus with the first few thousand copies of Sons and Fascination, a spectacularly odd thing to do from a band that hadn't really had a hit and were now 4 or 5 albums into a career. They'd already been ditched by Arista. Rather than go commercial, they ploughed their own path with extraordinary confidence. Jim Kerr says "In retrospect I think we tried to achieve the impossible. We wanted to record a double album on the budget of a single one. But at that moment, we were so full of ideas, and we thought they were all useful. So, we decided to record everything and ended up with a huge mess, a veritable nightmare".
Let's fast forward first though from 1981 to 1985. A confused (about everything) JO'B is starting to find himself. 15 and awkward as fuck, I started to develop some musical taste and quickly developed a habit that I have maintained for 36 years – if I like a band, go back and listen to their earlier stuff.
Simple Minds were one of my first obsessions, though New Order and The Smiths quickly joined them. Once Upon A Time and its preceding single, Don't You (Forget About Me) were my entry point. I loved them, and still do. They were big, loud grandiose pop. But they were also pretentious and political – everything that appealed to a very serious teenager. I quickly went back and bought Sparkle In The Rain and New Gold Dream (81+82+83+84) and was head over heels in love with them. The logo of Once Upon A Time was scrawled on my school bag and my notebook.
That Christmas, I went out with money I earned caddying for my old man, and finding lost golf balls and selling them. I was dragged around Lullingstone, usually sulking but grateful for the cash. I bought cassettes of their first four albums – Life In A Day, Reel To Real Cacophony, Empires & Dance and finally a cassette with both Songs & Fascination and Sister Feelings Call.
I remember sitting in my parents' lounge, with my headphones on, very proud of my new haul and playing them on the "good" stereo. I started with debut Life In A Day and was a bit shocked….this wasn't the majestic, enormous power rock of Once Upon A Time and or even the art synth pop of New Gold Dream. It sounds tinny, punk, odd – I was equally disappointed by the claustrophobic Reel To Real Cacophony. Empires & Dance had its moments but I was very confused. I love all three now, but on first listen this was new to me. I didn't realise bands didn't come fully formed, I had no brothers or sisters and the cool kids were not interested in weird little me. So, all my musical education was down to whatever I could borrow from the library, heard on the radio, read about in Smash Hits (and soon the NME) and checked out on listening posts when I trekked into London to visit the Virgin Megastore.
Despite my initial confusion, Sons & Fascination and Sister Feelings Call grabbed my attention immediately. The opening salvo of In Trance As Mission and Sweat In Bullet had me mesmerised. The former's offbeat bass intro caught my ear immediately, and the latter's Mick Karn-esque bass was frantic and funky. 70 Cities As Love Brings The Fall remains one of the strangest and most oblique song titles I have ever heard, and it includes what can only be described as this weird, honking drill-like synth sound. Yet it's wonderful and has the catchiest chorus "Follows in love, love brings the fall". No idea what it means, but I was hollering along on first listen.
Boys From Brazil was thundering drums, raw and angry, then Love Song takes us down to the disco, but it's nothing like any dance song I had ever heard before. This Earth That You Walk Upon and Sons and Fascination were both cold, stark synth epics, the former all distorted guitars, the latter almost Romanesque with its military, robotic drums.
Closer Seeing Out The Angel is sophisticated, Derek Forbes' slapped bass dominates along with Mick MacNeil's haunting synths and Jim Kerr's finest Bryan Ferry impression. It's the sign of things to come, and could easily fit on New Gold Dream.
The bonus album is just as good, kicking off with one of their perfect moments, Theme For Great Cities, probably the greatest instrumental I have ever heard. It remains in my most played songs on Spotify every year. The American is yet another perfect slice of distorted guitar pop, with more strange, impenetrable, cryptic lyricism:
"Ameri-Ameri-Ameri-Ameri-Amer-American, in collective fame Ameri-Ameri-Ameri-Ameri-Amer-American, Nassau club day"
But who cares? It's an earworm you don't want to remove. 20th Century Promised Land is another huge synth anthem, Wonderful In Young Life is more pounding drums, almost punk in places (original drummer Brian McGee was a massive and underestimated loss). Careful In Career and League Of Nations were the only tracks I would have relegated to B-sides. They could have then crafted one absolutely perfect album, but hey, I love their ambition and self-belief.
After this, they hit the charts with Promised You A Miracle and the perfection of New Gold Dream (81+82+83+84). Sadly, after the brilliant pomp rock of Once Upon A Time, they drifted into mullets, waistcoats, scissor kicks, too much pomp, too much rock, too much "let me see your hands", just too much…There were moments – See The Lights, She's A River, Real Life are great songs, but I lost them for a long time.
In 2012, I saw them as they played songs from their first five albums…I dragged a woman I was seeing who was a few years younger than me. She worried that I was dragging her to see more "old man music", but was suitably impressed. It was a cool show, and the standout moment was seeing Theme For Great Cities live – absolute heaven.
And I discovered the last four albums, Black + White, Graffiti Soul, Big Music and Walk Between Worlds are all wonderful – better than any band 40+ years into their career should be making. They rediscovered the balance between their "rawk" tendencies and some artistic, cool synth sensibility. Jim looks unfeasibly well and his voice is as good as ever and Charlie is a wonderful and vastly underestimated guitarist. I miss Del Forbes, Brian McGee and Mick MacNeil but their ever-rotating line-up of musicians is solid – Cherisse Osai is an AMAZING drummer!
My love for them remains strong and Sons And Fascination / Sister Feelings Call is their perfect moment for me. I remember as a 15-year-old sitting with a school friend in his bedroom playing records. He had bought Touch Me by page 3 glamour model Sam Fox; I had bought the 12-inch single of Sweat In Bullet. I knew then I was hanging out with the wrong crowd…
Sons And Fascination
Sister Feelings Call
Charlie Burchill
Derek Forbes
Mick MacNeil
Brian McGee


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Адриан Видяну е румънски политик, бивш кмет на Букурещ, Румъния и бивш румънски министър на икономиката (2008 – 2010).

Той е вицепрезидент на Демократическа Партия в Румъния, чийто президент е Емил Бок (бивш кмет на Клуж-Напока и настоящ министър-председател на Румъния). Тази политическа партия е сред водещите в държавата.

Бивш бизнесмен на гранит и мрамор, Видяну е избран за кмет през април 2005 г., събирайки 53,01% от гласовете на избирателите.

Видяну има жена Миорица и 2 деца.

Източници
 Официален сайт на румънски

Румънски министри
Румънски политици
Кметове в Румъния
Румънски бизнесмени
Личности (Букурещ)
Окръг Телеорман


Case Managers (CCM), Certified Rehabilitation Counselors (CRCC), Certified Disability Specialists (CDMS), Social Workers, Nursing (TNA) and others interested in case management related to rehabilitation and those with catastrophic illness and/or injury.
Registration 7:30, begins at 8:00 am.
An overall conference guide will be given to attendees at registration desk.
*Pending on line posting to the conference website as available from speaker. The handouts we received will be for your use to download electronically or to print out prior to the course. A Password will be sent out 1 week prior to the conference. The handouts will be attached to the lectures on the Schedule Tab.
Rehab Solutions is an advanced practice case management conference featuring nationally recognized experts in the field of rehabilitation. The one-day program will give you up-to-date information about current treatment and techniques and research initiatives that affect persons with catastrophic injuries and illnesses.
Updates on SCI Best Practices. We will discuss growing interest in revising multiple sets of clinical practice guidelines, creating a consensus on what constitutes quality care for SCI, and policymaking implications.
Watching Difficult Cases: Healthcare Professionals' Moral Distress. Discuss challenges in developing and implementing instruments, approaches, and interventions designed to identify and mitigate moral distress.
Viewing Self in the Mirror after an Amputation: The Unique Role of Healthcare Providers. We will explore a little-known realm of experience of altered body image and interventions needed, from healthcare providers.
Neurobehavioral Changes after Acquired Brain Injury: A Team Approach to Understanding Diagnosis and Interventions. We will identify common behavioral issues that can arise in BI patients and how these behaviors affect patient care.
School Reintegration for Children with Traumatic Brain Injury. This presentation will describe the components of a multidisciplinary approach to returning to school after brain injury including consideration of cognitive and psychosocial issues as well as mechanisms of educational support available to students.
Utilizing Technology in the Post-Acute Setting for Patient Safety. A Discussion of how Tele-Monitoring is being used in post-acute rehabilitation settings.
Courtenay R. Bruce, J.D., M.A., is an assistant professor of Medicine and Medical Ethics at the Center for Medical Ethics and Health Policy at Baylor College of Medicine. She is a lawyer with a background in health law. She also has a master's degree in bioethics, as well as training and certification in mediation and dispute resolution. While completing her master's, she completed a two-year fellowship at the Cleveland Clinic in clinical and transplant ethics.
Professor Bruce's experience in clinical ethics consultation is extensive. She has conducted over 3,500 clinical ethics consultations in tertiary and community hospitals. For 6 years, she was the director of the bioethics program for the Houston Methodist Hospital System. During her directorship tenure, the service grew from 50 ethics consultations a year to consistently conducting 450 ethics consultations a year. During this period, the service and its staff consistently achieved perfect scores on quality assessment surveys.
Professor Bruce currently serves as Director of Community Outreach, where her principal responsibilities include spearheading advance care planning initiatives and ethics education for churches, community hospitals, and schools nationwide.
Kerry has been with TIRR Memorial Hermann since 1995 where she worked as a staff nurse, nurse educator, clinical manager, and her current role as Nursing Director for the BI and Stroke Program. She provides hospital wide education by teaching Positive Behavioral Support classes, and in the Brain Injury family education series. She has published, with her colleagues of the SETx ARN, 2 research articles in the Rehabilitation Nursing Journal (RNJ): "Delegation in Knowledge and Practice Among Rehabilitation Nurses" In 2011 and "A Pilot for Understanding Interdisciplinary Teams in Rehabilitation Practice" in 2013. She currently serves as Treasurer for the SETx ARN Chapter and as Vice-President for Rehabilitation Services Volunteer Project (RSVP), a non-profit providing rehabilitation services to underfunded clients in the community.
Dr. Matt Davis, M.D., an assistant professor of physical medicine and rehabilitation (PM&R) at The University of Texas Health Science Center at Houston (UTHealth) Medical School, joined the medical staff of TIRR Memorial Hermann as an affiliated physician in 2011.
He was previously on the faculty at The University of Texas Health Science Center at San Antonio, where he was an attending physician on the Spinal Cord Injury Service. Dr. Davis earned his medical degree at The University of Texas Southwestern Medical Center in Dallas. He completed his residency in physical medicine and rehabilitation at the University of Colorado Health Sciences Center in Denver, followed by a fellowship in spinal cord injury (SCI) medicine at the University of Washington in Seattle.
Dr. Falco is an attending physician at TIRR Memorial Hermann, completed his residency at the Baylor College of Medicine/ University of Texas Health Science Center-Houston Physical Medicine and Rehabilitation Alliance in June of 2013. He received his medical degree in 2009 at The University of Texas Medical School in Houston, after completing his undergraduate education at The University of Texas at Austin in 2005. As an attending physician at TIRR, Dr. Falco's primary focus is caring for inpatients recovering from brain injury and stroke. He is a member of the American Academy of Physical Medicine and Rehabilitation, the Texas Medical Association and the American Medical Association.
Wyona M. Freysteinson, PhD, MN was born in Saskatchewan, Canada. She is an Associate Professor at the College of Nursing at Texas Woman's University in Houston, where she teaches courses in the undergraduate, graduate, and PhD Nursing Science Program. She is a faculty scholar of the Sigma Theta Tau International Nurse Faculty Leadership Academy 2014-2015 cohort. Her clinical specialties' include emergency, neurosurgery, home health, and hospice. Her unique research focus has been on the study of viewing self in the mirror. She has written several articles on the subject and has spoken to many audiences at a local, national, and international level. Wyona realized her work has culminated in finding the right words for nurses to use when helping patients view self in the mirror after disfiguring trauma or surgery. Her work has led her to research the broader horizon of the language of clinical scholarship.
M. Cullen Gibbs is a licensed Clinical Neuropsychologist and Pediatric Service Line Leader at TIRR Memorial Hermann. He completed a Ph.D. in School and Clinical Child Psychology at Texas A&M University. His pre-doctoral internship and post-doctoral fellowship in clinical neuropsychology were completed at the University of Minnesota Medical School. Dr. Gibbs has previously held positions at Children's National Medical Center in Washington, D.C. and Texas Children's Hospital in Houston. For the past seven years he has worked at TIRR Memorial Hermann performing neuropsychological evaluations, cognitive rehabilitation, and clinical research with persons who have experienced brain injury. His clinical and research interests include cognitive rehabilitation and the neurocognitive and neurobehavioral correlates of traumatic brain injury, stroke, and other neurological and neurodevelopmental conditions of childhood.
Margaret A. Struchen received her B.S. with Honors in Psychology from the University of Iowa. She received a Master's degree in Psychology and a Doctoral degree in Clinical Neuropsychology from the University of Houston. She completed an internship in clinical psychology from Henry Ford Health Systems and then completed a postdoctoral Fellowship in Clinical Neuropsychology and Rehabilitation Psychology at the Rehabilitation Institute of Michigan. Dr. Struchen is a clinical neuropsychologist, and currently serves as Director of Rehabilitation Psychology and Neuropsychology for the TIRR Memorial Hermann Rehabilitation Network in Houston, Texas. She has extensive experience in providing psychological services to inpatients and outpatients with brain injury and other neurological injuries or illnesses, including spinal cord injury and disorders. Dr. Struchen has an extensive record as a Principal Investigator and Co-investigator on numerous federally-funded research projects focused on rehabilitation of persons with traumatic brain injury, with special interest in the areas of community integration, social communication, interpersonal relationships, and understanding and improving outcomes following brain injury.
Lisa W. Thomas, DNP, APRN, CRRN.
Lisa W. Thomas, DNP, RN is a Clinical Nurse Specialist, with over 15 years of experience in the rehabilitation setting, managing staff education needs and clinical consultations for this population. A graduate of the UTSON DNP Executive Nurse Leadership program, she joined the faculty of the Acute and Continuing Care Department in 2016, and continues to pursue clinical practice opportunities with TIRR Memorial Hermann.
Her research interests include facilitating adjustment to disability, and nurses' transition into practice. Optimizing care quality through nurse-initiated projects is a continuing passion.
This course is valid for 6.0 contact hours for Nursing and Social Work; pending application approvals for CCM, CRCC, and CDMS.
*Watching Difficult Cases: Healthcare Professionals' Moral Distress (Ethics): *Is being submitted for 1 contact hour for Ethics/Jurisprudence for CCM, CDMS and CRCC continuing education requirements.
Course participants must complete any & all formal assessments, procedures, and criteria required for credit or certification.
CCMC, CDMS, and CRCC Ethics credit approval is pending for this course. The ANCC, CCMC, CDMS and CRCC Code of Professional Conduct and Ethics will be referenced in this presentation.
Memorial Hermann Health System is an approved provider of continuing nursing education by the Texas Nurses Association - Approver, an accredited approver with distinction by the American Nurses Credentialing Center's Commission on Accreditation.
Attendance, participation, and completion of feedback form.
Monday, February 12, 2017 or at registration capacity. Space is limited and registrations will be accepted in the order received.
Self-parking at the Norris Conference Center is free in the attached garage.
All cancellations must be in writing 14 calendar days prior to the course start date to ContinuingEducationRegistration@memorialhermann.org. Refunds will not be granted past this date. Cancellation of the event by TIRR Memorial Hermann will result in a full refund of monies received. TIRR Memorial Hermann is not responsible for the refund of travel or hotel expenses under any circumstances. TIRR Memorial Hermann reserves the right to cancel or change any programs for due cause. In the event of a course cancellation, participants will be notified via email & contact phone number on the registration form below. Please fill out all information in registration form.
Policy & Procedures exist whereby all speakers must disclose any relationships which may cause a conflict of interest. Any relevant financial and non-financial relationships will be disclosed via speaker agreement, written notification after agreement, and/or prior to presentation.
All participants in Memorial Hermann Continuing Education Courses are entitled to an accessible, accommodating, and supportive teaching and learning environment. Please email or note on registration any specific needs we can work to assist you with.


Through Trends Business Information, Roularta houses all financial and marketing data of every Belgian company. Roularta organises events in the fields of business and lifestyle and develops a whole set of line extensions in support of its strong brands: books and magazine specials, voyages and design.
In Belgium, The Netherlands and Germany RMG (in a 50 % joint venture with French group Bayard) is market leader in the senior magazines market.
Roularta possesses a 50 % participation in Mediafin (business newspapers De Tijd and L'Echo) as well as a 50 % participation in classified sites immovlan.be and autovlan.be/gocar.be.
Roularta employs 1,308 persons and produces a consolidated turnover of 277 million euros. turnover.


text:
Soundwalking the City with David Rothenberg
Shannon Henry Kleiber
The screeching of a fast-stopping car, the ding of an elevator, the flapping of pigeons, the clicks of heels, the whispered voices and voluble shouts. The sounds of a city are real and natural, in a different but no less arresting way from sounds in a forest, jungle, ocean or farm. Or so argues David Rothenberg, who co-produced an episode of "To the Best of Our Knowledge" that makes the case for exploring cities with our ears.
A composer and environmental philosopher, Rothenberg is best known for his work with sounds of nature: birds, whales and bugs, particularly. He said he'd avoided exploring the city — until he realized the sounds people typically try to tune out actually make each block unique.
"Usually people are trying to block out the noise of the city but it's actually interesting if you turn it up," said Rothenberg. "With this heightened sensory information it makes you more alive."
The way to hear the true sounds of a city, he found, is not by seeking out particular noises, but instead walking and wandering, seemingly aimlessly — using recording equipment and headphones to aid in discerning individual sounds from the sonic terroir.
To hone his method, Rothenberg wandered the streets of Manhattan, searching less for specific sounds and more for moments of beauty amidst the bustle you typically hear on the street in New York City.
"I wanted to be surprised," said Rothenberg. In the course of his "soundwalking," surprise had a way of finding him.
At the George Washington Bridge, Rothenberg approaches a construction worker who at first insists he doesn't have anything interesting to share with the microphone. David explains he's just wandering and listening to the city, and the man opens up, musing on what he prefers not to hear in the course of his day: a body falling into the water. He's heard it too many times, this unusual and unmistakable sound of someone jumping off the bridge.
People are not the sole noisemakers in urban space.
In a "tree-listening walk," Rothenberg is joined by David George Haskell, the author of "The Songs of Trees: Stories From Nature's Great Connectors," crunch-walking on mulberry leaves, listening to insects and voices and investigating the arboreal residents of Manhattan. With 20 percent of New York City having tree canopy, Haskell said, the city offers a fascinating urban nature walk.
So how does one listen to trees?
"Part of it is just showing up, year after year, to the same tree," said Haskell.
He listens with his hands, touching the trees. He hears how insects interact with the trees.
"If you put your ear up to the base of the tree, you can hear the scratchings of the woodpeckers in the top, the creaking of branches transmitted through the wood and into your ear," Haskell said.
Haskell and Rothenberg take in the completeness of a pear tree planted on a city block, complete with the sounds of helicopters, chewing insects and talking humans off in the distance. Some of the sounds hearken back to days past in the same place. The sunlight, too, has been shining in these very spots for generations.
Even what is new — cars and honking horns, subway stairwells swollen with riders en route, the bustle of digital bells and dings and alerts emanating from a thousand pockets — have a relative history to the place.
"The traffic is an echo of the energy that was present in the age of dinosaurs," Haskell said.
People have both changed the soundscape and are integral parts of it.
"Humans emerge from another part of the tree of life," Haskell said.
Haskell's insight reminds of his work listening to birds, especially nightingales, in another city, Berlin.
"They are not seeking silence," he said of the nightingales. "They pick territories and trees next to trains and busy spots."
It is this act of coexistence — the humans making sounds that the birds enjoy, and in turn the humans appreciating the nightingale's songs — that shows how people and nature rely on and delight each other.
"I'm interested in the overlap," Rothenberg said. "We're in this all together."
Listening to the City
davidrothenberg.net
itunes.apple.com
David Haskell
dghaskell.com
Survival of the Beautiful: Art, Science, and Evolution
Listening To Trees As Fellow Citizens
Singing The Song of a City
The Great Urban Nature Explorer
Reclaiming the Hidden History of South African Jazz
Can You Hear Segregation and Intolerance?


West Bengal Government invites online application for recruitment of General Medical Officer under Health & Family Welfare Department, West Bengal. There are a total of 1520 Vacancies. Apply the online application form before 1st December 2017 with out missing this golden opportunity.
1. The selection process will be based on the shortlisting done by the West Bengal Government on eligibility criteria.
2. In case of a large number of applications, a preliminary exam will be conducted and the same will be notified to you via email.
Maximum Age: Medical Graduates 36 Years and Medical Post Graduates 40 Years.
1. You should have medical qualifications that are included in the 1st/2nd/3rd schedule of the Indian Medical Council Act, 1956.
2. You should have also registered yourself as Medical Practioner in the Medical Council of India or any State Medical Council.


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50 years of legal gay sex: 1967 and all that by historian Jeffrey Weeks
This issue of Boyz is dated 27 July 2017, which marks exactly 50 years since the Sexual Offences Act 1967 received royal assent. The Act decriminalised homosexual acts in private between two men aged 21 and over. It also applied only to men living in England and Wales, and did not cover the Merchant Navy or the Armed Forces. It is, however, an important milestone in the fight for greater gay rights in the UK, as historian and author Jeffrey Weeks explains.
1967 was the summer of love. Its soundtrack was provided by the Beatle's Sgt. Pepper album and John Lennon's All You Need Is Love. London was still swinging. This was the year when the Sexual Offences Act partially decriminalised male homosexuality. It had taken a huge struggle to get reform through Parliament, but its leading supporter in the House of Lords, Lord Arran, issued an immediate dampener, urging those who had been in bondage to 'show their thanks by comporting themselves quietly and with dignity'. Not much room for love here.
This downbeat advice reflected the limited nature of the reform. Male homosexuality in private was decriminalised, as long as no more than two people were present, both were over 21, neither of you were in the armed forces or merchant navy, and you didn't live in Scotland or Northern Ireland. Homosexuality as such was not legalised, and prosecutions for public acts of indecency between men actually increased five-fold in the next few years. And, of course, change in the law did not affect lesbians or trans people at all.
I graduated from university in London in that summer of 1967. I was a boy from the South Wales valleys who slowly discovered the gay scene in London and had begun to find a circle of friends. I was politically aware and followed the debates about homosexual law reform. But its passage in late July 1967 almost passed me by. I was doing a summer labouring job back in the valleys, and my friendly mates never mentioned it. Nor did I. Like most of my fellow queers, I lived in two different worlds that rarely, if ever, communicated with each other. My gayness was completely separated from the rest of my life. The closet was deeply rooted in queer life and the 1967 reforms did little to change that.
Buggery between men had been illegal since the 16th century and carried the death penalty until 1861 – and after that a maximum sentence of life imprisonment. It was so draconian that increasingly juries had been reluctant to find people guilty. In 1885 a new offence of 'gross indecency' was introduced under the infamous Labouchère Amendment, carrying a prison sentence of two years, and this became a more effective template for prosecution of male homosexuality. It was the clause under which thousands of men had their lives ruined over the next 80 years, either directly through the courts or indirectly through blackmail – it became known as the 'blackmailer's charter' – or through a generalised fear of discovery and exposure. It was the law under which Oscar Wilde was imprisoned in the 1890s and Alan Turing, alongside many others, had their lives destroyed in the 1950s.
Queer life carried on despite the legal situation, and many people, famous and obscure, fell in love, had sex, formed relationships and created viable ways of life. But all the time the law cast its shadow, for women who were not directly affected as much as for men. The law symbolised a deep hostility in British society towards homosexuality and gender nonconformity that forced a double life, self-hatred and a constant anxiety about exposure. A steady increase in prosecutions from the late 1940s, especially in London, signalled that prejudice was increasing rather than decreasing. Britain gained a reputation as one of the most puritanical and anti-gay countries in the world by the 1950s.
Yet there were signs of change. A series of scandals – most notably the prosecution of Lord Montagu and Peter Wildeblood recently dramatised in the BBC's Against The Law – made homosexuality into a public issue. Was prison the best way of limiting and controlling homosexuality? 'Would you lock an alcoholic in a brewery?', the bisexual Lord Boothby famously asked. The Wolfenden Committee was set up by the government in 1954 to find a way through the mess. Three years later it came up with a policy that eventually shaped the 1967 reform.
It took ten years to get the law changed. That this happened was due in large part to the work of the Homosexual Law Reform Society, led by Antony Grey. Grey, like many of the workers and volunteers who led the campaign, was covertly gay, but the society presented itself as a respectable grouping of the great and the good, stuffed full of bishops, retired politicians, psychologists and writers. When it came to the crunch, the society did most of the work, but the kudos went to the (straight) politicians who pushed the law through parliament. It was done for us, not by us, and we should be suitably grateful.
The real change for me came not in 1967 but in 1970, with the emergence of the gay liberation movement, which made modern LGBT life possible. Coming out began to destroy the closet. It took until 1994 before there was any further law reform, when the age of consent was reduced to 18. It took another decade before the great wave of legal reforms occurred under the Blair-led Labour government, culminating in the Gender Recognition and Civil Partnership Acts. The years in between had seen the pain and anguish of the AIDS crisis, which fed into a vicious anti-gay backlash that culminated in the notorious Section 28, which banned the promotion of homosexuality in 1988. The road between 1967 and the achievement of formal equality and equal citizenship for LGBT people in the 2010s was long and erratic. The difference was that there was a new self confidence and public voice, rooted in an ever growing and flourishing LGBT world.
None of this would have happened without that first step in 1967. But from a historical perspective the reforms of that year look more like the end of an era than the start of something new. Fundamental change was to come with the a new sense of identity and consciousness after 1970. We were now doing things for ourselves, loudly and proudly – the beginning of a different world.
Jeffrey Weeks is a historian who has written widely about LGBT history. His pioneering book on LGBT politics and identity, Coming Out, has recently been republished in a revised and updated 40th anniversary edition by Quartet Books (quartetbooks.co.uk).
Related Items:Featured, Jeffrey Weeks


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Riley Jaquin #2
Oswego Girls Lacrosse
Class: Junior | Pos: A, M
2015-2016 29 4
Career Totals: 68 11
Draw Controls
Forced Turnovers
03/29/2016 vs. Syracuse W 9-5 2 — — — —
04/01/2016 @ Homer L 7-17 2 — — — —
04/11/2016 vs. Chittenango L 9-11 2 — — — —
04/13/2016 vs. Auburn L 8-11 — 1 — — —
04/19/2016 vs. Central Square L 7-12 1 1 — — —
04/23/2016 @ Fulton L 9-16 3 — — — —
04/26/2016 @ Mexico L 7-9 1 1 — — —
04/29/2016 @ Jamesville-DeWitt L 10-19 5 — — — —
05/05/2016 @ Jordan-Elbridge L 7-17 2 1 — — —
05/07/2016 @ Central Square L 8-12 3 — — — —
05/16/2016 @ Cortland L 10-15 4 — — — —
05/18/2016 vs. Mexico W 10-9 4 — — — —
Season Totals: 29 4 — — —


In aviation, adaptibilty and speed of response are essential. However it's not always cost effective to remain fully staffed, or to deliver every service in-house. At CAE Parc Aviation we provide flexible solutions to enable our clients to deal with unscheduled work or market demands, manage labour costs and access highly qualified and experienced flight crew and technical personnel.