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This entry was posted in Debit Card Activation on July 28, 2018 by A555.


text:
After Heart Surgery, This Rainbow Baby Gave His Parents the Biggest Smile
He's so happy to be alive.
By Sarah Schreiber
When Courtney Hayes found out the she was expecting for the fifth time, she decided to wait before getting excited. After four miscarriages — involving one failed round of IVF with genetic testing, which doctors told her had been a guarantee — she couldn't know for sure that this baby wouldn't be like the rest.
With a pregnancy journey like hers, those feelings of apprehension were understandable. Courtney and her husband, Josh, never had any trouble getting pregnant — she'd conceive, her hormone levels would rise appropriately and then nothing. There was radio silence during those early ultrasounds — no viable heartbeats, four times in a row. The couple says they were thick in the middle of the adoption process (they were done trying to conceive on their own), when Courtney conceived again.
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At eight weeks, the ultrasound was perfect — and it was perfect again at 11 and 14 weeks, a milestone for Courtney. And then everything came crashing down at 18 weeks. Their rainbow baby was reportedly diagnosed with Type 1 Truncus Arteriosus, a condition in which the heart has only one artery instead of two. Upon arrival, the baby (a boy!) would need immediate open heart surgery and, if he survived, subsequent surgeries over the course of his life.
Courtney and Josh decided to do everything they could for their son (they moved to be close to Children's Hospital of Philadelphia, where their baby would receive treatment) and, despite birth complications, Courtney delivered little Jude Hayes vaginally at the end of March 2017.
Shortly after his birth, doctors came back with shocking news — Jude was diagnosed with 22q.11 deletion (or DiGeorge) syndrome, a genetic disorder which meant that he would be on the spectrum. Courtney claims DiGeorge had been previously ruled out, which had been an error. "My heart breaks for Jude. He is so innocent. I hate life may be harder for him than for someone who has all of their chromosomes," his mom wrote on Facebook, shortly after the diagnosis. "I look at him and I want him to have the world. He is so beautiful to his dad and me."
And then, still upset from the DiGeorge diagnosis, they handed off their three-day-old son to doctors for open heart surgery. The surgery was a success — and the only person happier about it than Courtney and Josh was Jude. Despite recovery and sedation, Jude gave his parents a big smile when they needed it most, to let them know he was okay.
Today, just over a month after Jude's birth, his parents have taken him home. Their son isn't out out of the woods yet, and while settling in to life with a baby is overwhelming for any first-time parents, the Hayes family still has much to face in the coming months (and you can help!). Courtney and Josh are now trying to find medications that work, helping Jude eat without a feeding tube and advocating for their son as he begins his life as a child with special needs. They are facing these challenges as they come, together — with a smiley, optimistic little fighter by their side.
"Jude will write his own story and we are just here to help him write it," Courtney wrote. "Josh and I will give everything we have to help him write any chapter he desires, and I know it will be the most beautiful story I have ever read."
[h/t Babble
Emotional Photos of Dad Holding His Rainbow Baby
What It\'s Really Like to Have a Miscarriage
10 Uplifting Rainbow Baby Pregnancy Announcements
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redpajama_set_name: RedPajamaCommonCrawl


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text:
Our Organization Background/ Journey
A journey of thousand miles starts with a single and step.
The Rapid Action For Human Advancement Tradition(RAHAT) plays a pivotal role in the statewide effort to ameliorate poverty, to generate awareness and capacity building of the marginalized section of the society in general and of women in particular. The Rapid Action For Human Advancement Tradition(RAHAT)philosophy is oriented towards sustainable development through organizing groups of women and youth in target rural areas and judicious use of government resources for the large benefit of the people. Rapid Action For Human Advancement Tradition(RAHAT) a not–for-profit making organization envisages Capacity Building at all level through their Training and Consultancy wing for the development of the Society and Women Empowerment with the focus on sustainable Livelihood Promotion.
Rapid Action For Human Advancement Tradition(RAHAT)is a support institution that is committed to quality in Self-Help Banking registered in 2000 as a non-government public society, Rapid Action For Human Advancement Tradition(RAHAT) has already been recognized as a pioneering technical support organization in the field of promotion of Community Based Organizations (CBO) aiming to meet the needs of the various stakeholders involved in the promotion of member-owned and member-managed microfinance institutions.
The organization was established in 2002 having a team of dedicated professionals working with over 100 Self Help Group's poor households in Kishanganj district. Over the last years, Rapid Action For Human Advancement Tradition(RAHAT)has gained experience in promoting livelihoods initiating various methodologies. Rapid Action For Human Advancement Tradition(RAHAT)has been successful in standardizing intervention through sub-sectoral approach.
Our highly qualified key resource persons, along with their junior team working with a lot of enthusiasm and dedication The organization has imparted training to the adolescent girls of 5 different districts on 'Health, Hygiene & Sanitation and Nutrition, Education' under BEP (Bihar Education Project) supported by ICDS. Apart from this, currently the organization is supporting MAHILA HELP LINE & SHORT STAY HOME hand –holding activities supported by Women Development Corporation (WDC), Child labour Special School under NCLP Thruogh District Administration.
Rapid Action For Human Advancement Tradition(RAHAT) will strive to yield a competitive rate of return to its investors to be able to access mainstream capital and human resources on a continuous basis. The operating design of Rapid Action For Human Advancement Tradition(RAHAT)is geared towards providing a multiple set of services to rural poor households under one umbrella. This includes provision of micro finance, agriculture & business development and institutional development services In addition to this service, the organization has been involved in supporting WDC,UNODC and its project partners in conceptualizing the need, viability and process of building institution for wider impact of their project mandate.
Organizational Profile of Rahat


Eminem, *NSYNC, Macy Gray and BLUR are among the nominations for this year's MTV video music awards.
Eminem has been nominated for six awards, as have US boy band *NSYNC. Both have been nominated for Video Of The Year – Eminem for 'The Real Slim Shady' and 'NSYNC for 'Bye Bye Bye'.
In addition, the controversial rapper has also had his video, which features a cameo performance from Limp Bizkit's Fred Durst, nominated in the Best Male Video, Best Rap Video, Best Direction In A Video and Best Editing categories. *NSYNC have also been nominated for Best Group Video, Best Dance Video, Best Pop Video and Best Choreography In A Video.
Macy Gray, riding on the success of her debut album 'On How Life Is', has been nominated for four awards – Best Female Video, Best New Artist In A Video, Best Art Direction and Best Cinematography, while Blur have received a nomination for Best Breakthrough Video for their single 'Coffee + TV'.
Other artists nominated for awards include Britney Spears, Moby, Ricky Martin, Rage Against The Machine and Christina Aguilera.
The awards will take place on September 7 at Radio City Music Hall in New York.


Most deliveries will take 2-4 working days to reach you. For standard size items, if you need hand delivery service, please let us know and we will arrange it for you.
Any orders with a total purchase amount of over S$100, the delivery will be FREE!
We charge a flat rate of either $9.00 / $15.00 (depending on the item) on hand delivery service for total purchase amount of under S$100.
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Louise only had a short 30 km test in the car before the rally.
On the 2nd stage of Saturday Louise lost a little time when catching the car in front that started with a 2 minute gap. Louise was having difficulty seeing the road with all the dust from the car in front and trying to find a way past.
2nd loop of leg 3 Louise had a hard landing on the man-made jump in Coiluna.


Troubled insurance outsourcer Quindell has drawn the scrutiny of Lord Myners, the former City minister, who asked the Government whether the company, its board and its advisers were being investigated or if there were plans for a probe.
Lord Myners's query, which was first reported by the Financial Times, was answered at the start of December by Baroness Neville-Rolfe, the former Tesco director of corporate affairs, who noted that "any enquiry relating to possible market abuse sits within the remit of the Financial Conduct Authority".
The Baroness said: "The Government's Insolvency Service has discretionary powers under the Companies Acts to conduct enquiries on behalf of the Secretary of State where it appears that there has been misconduct in relation to the affairs of any company, including those not subject to formal insolvency.
What next for investors in Quindell?
"For the investigation process to be effective it is essential to maintain confidentiality at all stages and there is also a need to protect the commercial interest of companies against the danger of damage from malicious complaints.
"For these reasons there are legal restrictions on disclosing information obtained during an enquiry and The Service does not confirm or deny whether an investigation of a particular company is taking place.
Mr Terry was forced from the board of the Aim-listed group last month when it emerged that he had effectively sold shares to an American stock lending firm, Equities First Holdings (EFH), as part of a complex financing deal.
The arrangement was initially described as a loan to help him raise funds to increase his Quindell stake. However, the company was later forced to admit the agreement was a sale and repurchase deal and that Mr Terry's net shareholding in the company had decreased, news that sent the stock plummeting.
The shares fell further when it was revealed that one of Quindell's house brokers had resigned.
Canaccord Genuity gave notice of its resignation to Quindell in October. But Quindell only publicly announced the broker's exit in November, after the trio had struck the EFH agreement.
The insurance outsourcer disclosed Canaccord's resignation when it decided, following advice from its remaining broker Cenkos Securities, that the information was market-sensitive.


text:
Q: Strange x-axis in histogram for discrete variable in R I have some discrete data that I'm trying to plot in a histogram in R. I'm using the built in hist() function, which works fine most of the times for the data I have. However, when it comes to a discrete variable it looks somewhat strange (unfortunately I cannot add the picture). I interpret it as "since the bin for 0 and 1 children must fit between 0 and 1 it determines the width of all bins and thus the "from 1.5 to 2" result". How can I put the numbers on the x-axis centered underneath each bin instead?
Thanks in advance!

A: You might want to consider drawing the axis in a second step:
Prevent x-axis with xaxt="n":
hist(cars$speed, xaxt="n")

Draw x-axis and adjust label position with hadj=:
axis(1, at=seq(0,25,5), hadj=2.5, labels = c("",seq(5,25,5)))

redpajama_set_name: RedPajamaStackExchange


I Just Got a Spy Earpiece…Now How Do I Wear it?
In simplest terms, the loop goes around your neck and the small earpiece goes inside of your ear. It is important, however, to ensure that the loop is well concealed, otherwise it can totally give the game away. Wear a high collared shirt or blouse in order to hide the loop around your neck.
The earpiece itself is usually flesh coloured (different shades and skin colours are available), but even if it isn't, the earpiece is so small that people are unlikely to even notice it.
The microphone needs to be positioned near to your mouth, but not so near that people can see it. Once again, a high collar will be of some service here, because you can place it underneath the collar line (spy earpiece microphones tend to be rather powerful for their size – but remember to test the whole setup first before you go into the field). If you happen to be wearing a tie, then so much the better, because the microphone can be easily clipped behind the tie (where it is very unlikely to be noticed).
Next, take the loop (making sure that it is under your clothing) and ensure that you can easily access the battery, beeper button and any other attached gadgets. You can run the battery straight into your pocket, provided your shirt is long enough, or, if you're feeling particularly clever, you could even cut a small hole inside of your jeans pocket and thread the beeper/battery through the inside of both your shirt and your jeans (this will also work for your phone).
The hardest things to hide will be your attached cellphone or two-way radio. The cell can sit, quite happily, in your pocket (in fact, people generally expect you to be carrying one anyway), but the earpiece's connection to the headphone socket must not be seen (keep it under your clothes, as discussed above). The two-way radio option is a little more difficult. Two-ways can be hidden on your belt (underneath loose-fitting garments), around your back (again, covered by clothing) or even strapped to your leg. It is definitely harder to hide a two-way, so it isn't the ideal option for prolonged covert usage.
Finally, we advise you to check the whole thing out in the mirror first. Make sure that outside influences such as wind, rain, pushy crowds or actions such as running to catch a train are not going to expose your subtle setup. If you think you are too exposed, try different permutations on the advice provided, until you find something that works for you.


text:
Holma bispicata, unique représentant du genre Holma, est une espèce d'araignées aranéomorphes de la famille des Linyphiidae.

Distribution
Cette espèce est endémique d'Angola.

Publication originale
 Locket, 1974 : Notes on some African linyphiid spiders. Publicações culturais, Companhia de Diamantes de Angola, , .

Liens externes
 genre Holma :

 espèce Holma bispicata :

Notes et références

Linyphiidae
Espèce d'araignées (nom scientifique)
Faune endémique d'Angola

redpajama_set_name: RedPajamaWikipedia


text:
package org.apache.xmlrpc;

import java.util.Vector;

/**
 * An XML-RPC handler that also handles user authentication.
 *
 * @author Hannes Wallnoefer
 * @see org.apache.xmlrpc.AuthenticationFailed
 * @version $Id: ContextXmlRpcHandler.java,v 1.2 2005/04/22 10:25:57 hgomez Exp $
 * @since 1.2
 */
public interface ContextXmlRpcHandler
{
    /**
     * Return the result, or throw an Exception if something went wrong.
     *
     * @throws AuthenticationFailed If authentication fails, an
     * exception of this type must be thrown.
     * @see org.apache.xmlrpc.AuthenticationFailed
     */
    public Object execute(String method, Vector params, XmlRpcContext context)
            throws Exception;
}

redpajama_set_name: RedPajamaGithub


Just a few hours after the debate in the House Commons on whether Britain should bomb Syria, British bombers made their first strikes on the so-called Islamic State in Syria, today, Thursday December 3rd 2015.
The strikes targeted oil fields that Prime Minister (PM) David Cameron says are being used to fund attacks on the West.
Tornado bombers took off from the RAF Akrotiri air base in Cyprus just hours after British lawmakers voted 397 – 223 to support Cameron's plan for air strikes.
Several hours later, the bombers returned to base safely. Cameron has already warned that the campaign will "take time", meaning there are more jets that will be flying to Syria.
Leading the opposition to the strikes, Labour leader Jeremy Corbyn stated, "David Cameron's case was not convincing, lacking either credible ground troops or a plan for a diplomatic settlement".
"Since he first made his case for airstrikes in Syria, last Thursday [26 November 2015], opposition has mounted; in the country, in parliament and in the Labour Party".
Protesters in London against Britain going into "yet another war", have been saying "#DontBombSyria"; citing lessons to be taken from previous conflicts in the region. The issue that bombing Syria will inevitably involve civilian deaths just like in Afghanistan, Libya and Iraq, was the common point shared across those opposing the airstrikes.
In a closed-door meeting, Cameron reportedly called MPs who opposed airstrikes, "a bunch of terrorist sympathisers" – much to the disapproval and outrage both in parliament and social media.
Despite over 12 calls from MPs in the debate during the Commons debate for the PM to retract his comments, Cameron did not apologise.
Twitter was sent into a paroxysm of rage as users shared their anger over Cameron's comments. Isa Guha wrote, "This is getting a bit ridiculous now. How can you be a terrorist sympathiser for not wanting innocent people to die??? #DontBombSyria".


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The pursuit of excellence is no accident. Greatness has never been achieved by anyone overnight. Explore the lives of people who demonstrate brilliance in their fields, and what you will find is people who passionately and committedly make consistent efforts towards their goals.
Every great journey begins with the first step, but we only arrive at our destinations by taking the next, and the next, and the next … you get the idea.
Read an autobiography of someone you admire and see what it took for them to succeed. Google your favorite business leader, athlete or performer to discover how they got where they are today.
Where could you be even more consistent in your effort to more quickly and completely realize your priority goals?


Covert police officers have been patrolling the streets of Leighton Buzzard for 24 hours a day over recent weeks.
Beds Police says it is taking burglary in the town extremely seriously following a spike in offences. The force's intelligence department identified the rise in dwelling burglaries, resulting in the extra patrols.
The initiative has resulted in nine arrests - seven boys and two men – and several warrants conducted on properties.
Three people have been charged, four are currently on police bail, one was dealt with by a neighbouring force, and one was released with no further action.
Overt community police officers and PCSOs are continuing visible patrols in the town to assist with public reassurance.
Residents are encouraged to speak to police and report any suspicious activity they see, as well as take advantage of helpful home security and personal safety advice.
Det Insp Duncan Young, from the force intelligence department, said: "Intelligence is an invaluable tool in the fight against crime and it is vital that we continue to work with the public to gather a picture of offending in the county.
"Those with information about crime or suspicious activity are reminded that they can report useful details using the police non-emergency number 101, anonymously through Crimestoppers, or through their local Neighbourhood Watch.
Dwelling burglary across Bedfordshire is down by26.4% in the financial year to date compared with the same period in 2014.
Additionally, the rate of solved crime has increased by 4.1 per cent over the same period.
Have you been affected by burglary? Email news@lbobserver.co.uk and tell us your story.


These dark chocolate avocado truffles are tasty, but have the added benefit of actually being pretty good for you, considering what a delicious sweet treat they are! I'm making these as a snack, and may take some more to a new years party we are attending if they go down well.
Break chocolate into chunks and place in a glass mixing bowl above a pot of water. Just simmer the water and stir the chocolate as it's melting. Once fully melted stir in the agave syrup (or sugar). Set aside to cool.
Scoop out the avocado flesh, add the salt and using a fork mash to a pulp.
Gently fold the avocado into the melted chocolate. Put in the fridge for at least 30 minutes, or until it firms up. When nearly ready put your chosen coatings in small bowls.
Roll the chocolate mixture into balls, dip the balls into the coatings and cover. Continue until all the chocolate mixture is used up.
Put truffles in an airtight container and chill for another 30 minutes. Use within two days.
I will update with pictures once I've made them, but I have made similar truffles previously and they were delicious! Here you can see my full christmas menu and feel free to follow me on facebook, twitter and instagram.
I was walking through the supermarket today and I saw some nice looking rhubarb, and the weather is decidedly wintery, (and having a couple of packets of blueberries in the fridge), I decided on a whim to knock up some vegan rhubarb and blueberry crumble.
Pre-vegan days, I used to eat a fair whack of hot deserts, but the unavailability of vegan offerings in the supermarkets has lead to me pretty much giving them up entirely. Therefore, I was looking forward to this for pudding!
Chop rhubarb into thumb sized chunks. Put in saucepan with blueberries, Golden Caster Sugar and a little water. Cover and simmer for 15 minutes on a really low heat. Be careful because the rhubarb can easily lose it's shape if overcooked.
When soft pour into a baking dish. Heat oven. Rub flour mix and margarine together. Add sugar.Mix up with your hands. Scatter on top of the rhubarb and blueberry mix.
Cool in the oven at 180C for a fan oven for about 30 minutes. I had mine with Alpro soya single cream.
Here you can see more of my food and this is the recipe that inspired this crumble. It was lovely! Simple, comforting food, recommended!
As my first proper post I thought I may as well start with a biggie, I faced a huge challenge this week, creating a Vegan Birthday Cake for my daughter's 8th Birthday. After trying a number of recipes I found that one using aquafaba gave the best bake. Honestly, since going vegan the resourcefulness of the bakers and cooks out there still surprises me, chickpea brine for egg replacer sounds insane but really works, there is no taste but it gives the correct texture for a cruelty free vegan birthday cake. I can't say this would work well for my weight loss, but it definitely did the job in satisfying the kids, friends and family. Pictures are at the bottom of the post.
The following recipe which was found originally here was used for each layer of the cake ( three times in total) with a couple of small differences.
Preheat Oven to 160 Degrees (fan) or 180 Degrees.
Using a large bowl add vinegar to aquafaba and whip using an electric hand blender. Whipping has to continue for around ten minutes until the mixture resembles egg whites, forming peaks. I found that I struggled to get the aquafaba whipped enough, and after some googling found some suggestion it may have been due to my blender being rather basic (not strong enough), so added half a teaspoon of cream of tartar which seemed to do the job.
Sugar should be added until the mix goes glossy. Next add in the oil and vanilla. At this point for each of the three layers I added in around a third to a half of a tube of food colouring.
Next I sifted the flour, baking powder and bicarbonate of soda into the frothy mixture and gently folded this in.
I used a single 7 inch baking tin which gave a good rise, this needed to be lined and greased.
The cake was put in the oven for 25 – 35 minutes, when a toothpick comes out clean I left the cake in the tin for 5 minutes then transferred to a rack.
After the cakes had began to cool I mixed up sugar syrup by boiling one cup of water and one cup of sugar until it was a thick syrup. I poked small holes in the top of the cakes then using a brush, brushed the syrup all over the cakes. I was worried that the cakes would be dry as a few test cakes I made had been a weird dry texture but the sugar syrup really seemed to help.
Buttercream was 100g dairy free spread mixed with 200g Icing Sugar and some vanilla essence.
Finally, pre made fondant icing was used for the panda. I need to improve my decorating skills! However, the cake tasted delicious. All of the kids at my daughters birthday party loved it, and even the parents, and my family and friends were shocked when they tasted it and knew it was a vegan birthday cake made with chickpea juice!
To see more recipes relating to baking please click the link. Also, you can view my overall food page which also has links to other meal sections.


Please include your phone number if you would like for us to call you. We're here to make it as easy as possible to get quality insurance coverage today.
Whedbee Insurance Agency provides email quotes for our full lines Commercial Insurance. All information collected here goes directly to Whedbee Insurance for the sole purpose of sending you a quote for insurance. No small print here - Your information will only be used by us (Whedbee Insurance Agency) for this quote.
We have been clients of Whedbee Insurance Company for over almost 20 years. They are a family owned business, and provide excellent service. Over the years, we have had some auto accidents, thefts, and claims for our home. During these incidents, Whedbee Insurance was just one phone call away!


In Slovyansk during the antiterrorist operation confirmed the information about the killing of three terrorists. Two of them are citizens of the Russian Federation. Also, according to radio intercepts there are some kolichesvto killed and wounded, according to sources in the Interior Ministry.


A panel discussion at the 1992 national Evangelical Theological Society between Drs. Greg Bahnsen (postmill/reconstructionist), Jack Deere (charasmatic/Vineyard), George Knight (amillennial/Reformed), Robert Saucy (Dispensationalist) - Four Views of the Kingdom of God. A very interesting presentation of the kingdom, touching upon millennial issues, timing and effect of the kingdom.


text:
Churches of New Mexico
Farming & Ranching
Tribes of New Mexico
Photo Conservation
Rights & Use
A Pictorial History of New Mexico
curated from public archives
and personal collections
The historic pictures in this archive chronicle life in New Mexico up through the early 20th-century. Old photographs, vintage documents and ephemera, and other materials form a narrative of the people, places, and events that have shaped New Mexico's cultural identity.
Clara Belle Williams, c. 1900
Clara Belle Williams (1885–1994) was the first African-American graduate of New Mexico State University, in 1937. She was born Clara Belle Drisdale, the daughter of sharecroppers in Plum, Texas, in 1885. She graduated from Prairie New Normal and Independent College (now Prairie View A & M University) in 1905 as valedictorian of her class. In 1917 she married Jasper Williams, and eventually the couple settled in Las Cruces, New Mexico.
While teaching at Booker T. Washington Elementary School in Las Cruces, Williams began to take classes in the summer of 1928 at New Mexico College of Agriculture and Mechanic Arts (now New Mexico State University). Professors would not allow her in the classrooms because she was black, so she took notes from the hallways—standing up, as she was not even provided a chair. Williams persevered, and in 1937, at the age of 51, she graduated with a B.A. in English. She was not allowed to walk with her class in the graduation ceremony, which did not stop some of the other graduates from boycotting the event. Williams continued to take graduate classes well into the 1950s.
Grant's Opera House Fire, Albuquerque, 1898
In June, 1898, a fire broke out at the Grant Building, on the northwest corner of Railroad Ave. (now Central Ave.) and Third Street in Albuquerque. Volunteer firemen fought the flames, but the building was destroyed. The Grant building housed several stores on the first floor, and the Grant's Opera House on the second floor. It was later rebuilt, but without the opera house.
Insurance Office, Albuquerque, 1897
Selling insurance, 1897 Albuquerque style. The New York Life Insurance office was located in the N. T. Armijo building, on Second Street just north of Central Ave. It's an interesting look at an office of the time—the rolltop desks packed full of papers, the wooden swivel chairs on rollers (I had no idea they existed back then, but it turns out swivel chairs were invented by Thomas Jefferson in the 1770s), and the stove with its long pipe. The carved doorframe is still a familiar sight today in many Albuquerque homes and buildings. And of course, no office is complete without a small dog napping in front of the stove. This photo is one of a series taken by William H. Cobb of Cobb Studios in Albuquerque.
1867 Map of Arizona and New Mexico
This beautiful map of Arizona and New Mexico was produced by S. Augustus Mitchell in 1867, probably as part of Mitchell's New General Atlas published by his company (this is not stated in the Library of Congress notes on it, but is the same map used in later volumes of the atlas). In addition to counties and towns, the map notes Native tribal territories and pueblos, Indian and Spanish trails, military routes, and wagon and caravan routes. Mitchell's hand-colored maps were known for their pastel colors, vine borders, and detailed geographical features.
Goyathlay (Geronimo), 1887
This portrait of Goyathlay (aka Geronimo, Spanish for Jerome) was taken by Ben Wittick in 1887, after the Apache leader's third and final surrender and deportment to Florida. Goyathlay led the last Native American fighting force to formally surrender to the United States, after nearly 30 years of fighting against Mexican and American troops. His daring raids, numerous escapes, and ability to evade thousands of troops for decades made him one of the most famous, and feared, Natives of the time.
Goyathlay ("One Who Yawns") was born in 1829 to the Bedonkohe band of Apache near Turkey Creek, in the Gila Mountain region of what is today New Mexico, but was then still Mexican territory. Goyathlay was not a chief, but after marrying into the Nednhi band of Chiricahua Apache he became a spokesman for their chief, his brother-in-law Juh, who had a speech impediment. As a result, he was often mistakenly assumed to be the leader by outsiders.
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1927 Map of Route 66, New Mexico
George McJunkin, Discoverer of Folsom Man Site
Old Variety Stores in Albuquerque, 1895
Stagecoach in Los Griegos, New Mexico, 1883
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All visions of finishing the work I had planned went out the window. But luckily for me, my husband agreed to work from home for an hour while I went and grabbed the files I was working on for the blog. Love you Honey!
I was asked to take some photos for Eastwood's walkathon today. It was super fun to see all the kids so excited.
I am thrilled that Spring is officially here. It has been feeling like Spring on and off for weeks now, but we can officially celebrate now. Yes, I know it may still snow. This is Northeast Ohio.
One of the coolest thing about living in a place like Oberlin is taking advantage of the amazing talent the College brings to town. Last night we got to listen to Brian Greene give a talk about Physics and String Theory, for free.
Sometimes I just need to get out and take a walk with my camera. It helps me to refocus on my eye, my art and my self.
I am so thankful for my family and friends in Ohio, Massachusetts and everywhere! But I am truly grateful that we made the leap to Ohio and our new life here. It feels right. I love our home and our community and I am excited to see what comes next for us.
The Big Move is Here!
Well, it is finally here. I am shoving off. Our house is sold, our things are in storage. B is already in Ohio at his new job and I am taking off on a road trip with the boys. I had to try to pack everything we would need for 7 weeks of living without our stored items. Not so easy to come up with this list. I also had to have room in the car for my computer, monitor, hard drives, cameras, and US of course.
If you live in the Boston area, you HAVE to stop into their shop in Watertown. You walk in and are hit by these incredible smells of roasted nuts and chocolate. OMG!
My big guy graduated from preschool today. He started at Learn and Play Preschool when he was 2 years old, going 2 mornings a week. It was just the break we both needed. He always had a blast there and the teachers are amazing. They somehow managed to teach my son all his letters and the sounds they make without him ever "wanting" to sit and learn these things. Usually he would build with blocks, building his inventions. But the teachers really make learning fun and they encorporate learning into all kinds of activities. So he was learning without actually realizing it. Amazing.
Asa turned 3 today and we celebrated with a Pink Party. He is obsessed with the color pink and I wanted to let him have a big pink party while he still could. We told everyone to come dressed in pink or red.
So today's "fill in the blank" was going to Davis Farm Land in Sterling, MA. This place is awesome. They have animals and fun activities including a big water park. The kids always have a blast here.
I have been super busy this past weekend. I took a quick trip to Ohio to look at houses (I didn't see any that blew me away), but I did love checking out our new town by myself. I even saw a movie by myself (all you new moms know this NEVER happens). Very enjoyable.
OH MY GOSH! B got the job! We are still silly with the news. I can't believe it. Thank you to the committee for seeing B's potential. I think he is going to do so many incredible things in this position.
Life has been really crazy around here lately. My husband has found his dream job. There is just one catch, it is a job working for our alma mater, in Ohio. Big changes, big move. The timing is great for our kids because they haven't started school yet, but it is always scary starting over in life. I can't imagine leaving all my wonderful clients behind, not to mention our friends.
Well, she called me up the other day and asked if I would lend my artistic eye to a beautiful and unique house that she is representing (she is a realtor). I made no promises (since architectural photography, in my opinion, is the most difficult type of photography) but agreed to give it a go. Well, this house is AMAZING and it wasn't hard to capture its incredible lines and beautiful spaces and artwork.
Okay, so I know this isn't the "normal way" to celebrate Valentine's Day, but it was definitely memorable, and I was with two men (well boys) that I love.
These seminars are a great way for photographers to get together to learn from each other, see new products and push each other to be better photographers. I try to attend seminars and classes as often as I can.
Thanks to my mother-in-law for the great present of tickets to see the show Rent.


text:
Horn anvendes i flere sammenhænge:

I dyreriget
 Horn (anatomi) – en udvækst på et dyrs hoved.
 Drikkehorn - et horn fra eksempelvis en okse til at drikke af
 Horn (materiale) – det stof, (keratin), som fx kohorn er lavet af.

Geografi
 Horn (geografi) – en betegnelse for et "fremspringende" landområde, f.eks.
 Afrikas Horn.
 Kap Horn – Sydamerikas sydligste spids.
 Horn (Tvilum Sogn) – en landsby
 Horn (Island) – en by på Island
 Horn (Schweiz) – en schweizisk by ved Bodensøen
 Horn (Brønnøy) -
 Horn (Hamborg) -
 Horn (Hunsrück) -
 Horn (Kinda kommun) -
 Horn (Limburg) -
 Horn (Niederösterreich) -
 Horn (Östergötland) -
 Horn (fjeld) - et 591 m højt fjeld på den færøske ø Eysturoy

Lyd og Musik
 Horn (musikinstrument)
 Signalhorn
 Jagthorn
 Valdhorn
 Lur (horn)
 Gjallarhornet – fra nordisk mytologi.
 Horn (apparat) til signalgivning på motorkøretøjer og skibe. I gamle dage udformet som båthorn på biler.

Navne
 Horn (efternavn)
 Horn (adelsslægt) – en svensk adelsslægt

Medier og underholdning
 Horn (film) – en dansk dokumentarfilm fra 1986
 Horn (band) – et norsk band

Andet
 Horn (brød) – et stykke morgenbrød, som har navn efter faconen
 Horn bruges om den fremspringende del på en ambolt.


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text:
Mazarredia africana är en insektsart som beskrevs av Bolívar, I. 1909. Mazarredia africana ingår i släktet Mazarredia och familjen torngräshoppor. Inga underarter finns listade i Catalogue of Life.

Källor

Torngräshoppor
africana


text:
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Search title on
Associations of sex-hormone-binding globulin (SHBG) with non-SHBG-bound levels of testosterone and estradiol in independently living men.
Jong, F.H. de;
Pols, H.A.;
Gooren, L.J.;
Grobbee, D.E.;
Muller, M.;
Schouw, Y.T. van der;
Ronde, W. de
text/plain;
image/pdf;
Journal of Clinical Endocrinology and Metabolism 90(1), 157-162 (2005)
http://igitur-archive.library.uu.nl/med/2006-0906-200655/UUindex.html
DSpace at Utrecht University
Jong, F.H. de
Pols, H.A.
Gooren, L.J.
Grobbee, D.E.
Muller, M.
Schouw, Y.T. van der
(c)UU Universiteit Utrecht, 2005
http://retrievo.pt/record?id=oai:dspace.library.uu.nl:1874/12511
Associations of Sex-Hormone-Binding Globulin (SHBG) with Non-SHBG-Bound Levels of Testosterone and Estradiol in Independently Living Men
Willem de Ronde, Yvonne T. van der Schouw, Majon Muller, Diederick E. Grobbee, Louis J. G. Gooren, Huibert A. P. Pols, and Frank H. de Jong
Department of Internal Medicine (W.d.R., H.A.P.P., F.H.d.J.), Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands; Julius Center for Health Sciences and Primary Care (Y.T.v.d.S., M.M., D.E.G.), University Medical Center 3508 GA Utrecht, The Netherlands; Department of Endocrinology (W.d.R., L.J.G.G.), Vrije Universiteit Medical Center, 1007 MB Amsterdam, The Netherlands; and Department of Epidemiology and Biostatistics (H.A.P.P.), Erasmus Medical Center, 3000 DR Rotterdam, Netherlands
Results of in vitro experiments indicate that with increasing concentrations of SHBG, testosterone (T) is preferentially bound to SHBG in comparison with estradiol (E2). In these studies, the ratio of non-SHBG-bound E2 (non-SHBG-E2) to non-SHBG-T increasedwith increasing levels of SHBG. SHBG has consequently been regarded as an estrogen amplifier. In this cross-sectional study in 399 men aged between 40 and 80 yr we tested whether higher levels of SHBG are associated with a higher estrogen/androgen ratio in vivo. The mean T level of thesemenwas in the eugonadal range [536� 152 ng/dl (18.6 � 5.26 nmol/liter), mean � SD]. With increasing SHBG levels the non-SHBG-bound fraction of T decreased from 80 to 36% and that of E2 from 89 to 53%. Higher levels of SHBGwere associated with higher levels of both total T [regression co-
efficient (�) after adjustment for age and body mass index, 286 � 15.8; P < 0.001] and total E2 (� � 4.47 � 0.90; P < 0.001). However, SHBG levels were negatively related with levels of non-SHBG-E2 (� � –1.78 � 0.69; P < 0.001), whereas there was a positive association between levels of SHBG and non- SHBG-T (�� 32.0� 9.78;P� 0.001). Furthermore, we observed a negative relationship between SHBG levels and the E2/T ratio of either total (� � –0.016 � 0.002; P < 0.001) or non- SHBG-bound (� � –0.011 � 0.002; P < 0.001) hormone. There- fore, we conclude that in eugonadal men, higher SHBG levels are associated with lower levels of non-SHBG-E2 but slightly higher levels of non-SHBG-T. Thismeans that SHBGcannot be regarded as an estrogen amplifier in eugonadal men. (J Clin Endocrinol Metab 90: 157–162, 2005)
SHBG, corticosteroid binding globulin, and albumin areimportant steroid hormone binding proteins in human plasma. Although recent evidence shows that SHBG can participate in signal transduction via its own membrane re- ceptor (1), it is best known for its role as a binding protein of sex hormones in human plasma. In normal men and women, between 40 and 65% of circulating testosterone (T) and between 20 and 40%of circulating estradiol (E2) is bound to SHBG (2). Binding of T to SHBG decreases its metabolic clearance rate and its conversion rate to androstenedione (3). Binding to SHBG also prevents bound hormone from dif- fusing out of the bloodstream, thereby preventing hormone binding to the intracellular androgen or estrogen receptors. The non-SHBG-bound fraction of hormone is, therefore, con- sidered to be bioactive (free hormone hypothesis as reviewed in Ref. 4). T and E2 bind to the same binding site on SHBG, but the
binding affinity for T is higher than that for E2 (5). In vitro experiments show that with increasing levels of SHBG and stable levels of T and E2 the ratio of unbound E2 to unbound
T increases (6). On the basis of the relatively greater decrease in the bioavailability of T compared with that of E2, SHBG has been regarded as an estrogen amplifier. This might pro- vide an explanation for the gynecomastia frequently ob- served in thyrotoxicmen because thyrotoxicosis is associated with high concentrations of SHBG (7–9). An alternative ex- planation for this observation might be that levels of LH in these patients are increased, causing an increase in testicular E2 production (10), although others did not detect increased E2 production rates in hyperthyroidism (11, 12). In healthy males, there is a wide variation in SHBG concentrations. In cross-sectional studies, the plasma concentrations of T and SHBG are positively correlated (13). This correlation not only reflects the high binding affinity of SHBG for T, resulting in increased storage of the steroid, but may also be explained by the effect of SHBG levels on the bioavailability of T. Higher SHBG levels would then lead to lower levels of bio- active T, a decreased feedback signal on GnRH and thereby on LH secretion by the pituitary and a subsequent increase of T levels until a new set point is reached. This dependence of total T on variations in SHBG in men in vivo differs from the stable T levels in the in vitro experiments described above. It is, therefore, doubtfulwhether the conclusions drawn from these in vitro experiments apply to the in vivo situation. The aim of this study was to evaluate whether the relationships between T, E2, and SHBG in healthy men support the con- clusions based on the in vitro experiments.
First Published Online October 27, 2004 Abbreviations: BMI, Body mass index; E2, estradiol; HPG, hypo-
thalamo-pituitary-gonadal; non-SHBG-T, non-SHBG-bound T; T, testosterone. JCEM is published monthly by The Endocrine Society (http://www. endo-society.org), the foremost professional society serving the en- docrine community.
0021-972X/05/$15.00/0 The Journal of Clinical Endocrinology & Metabolism 90(1):157–162 Printed in U.S.A. Copyright © 2005 by The Endocrine Society
doi: 10.1210/jc.2004-0422
on August 9, 2006 jcem.endojournals.orgDownloaded from
Subjects and Methods Subjects
The study is a cross-sectional, single-center study of 400 indepen- dently living men aged 40–80 yr. The study was originally designed to study the relationships between endogenous sex hormones and risk factors for, or manifestations of, chronic diseases. The subjects were recruited by asking female participants of other studies conducted by the department whether they knew any man who might be interested in volunteering for the study. Invitation letters were sent to 770 female participants. Eventually, 240 men volunteered for participation.
Subsequently, names and addresses of a randomly selected male population aged 40–80 yr were drawn from the municipal register of Utrecht, a large town in the middle part of The Netherlands. A total of 1230 invitation letters were sent. From this group, 390 men volunteered for participation.
From the 630 volunteers we excluded the subjects who did not live independently and subjects who were not physically or mentally able to visit the study center independently (n � 16). No additional health- related eligibility criteria, other than being physically and mentally able to visit the study center independently, were used. Of the remaining 614 men, 400 men were randomly selected to participate. To obtain equal numbers in each age decade, we sampled 100men in each decade of age. One subject was excluded from analysis because of clear hypogonadism [total testosterone � 6.91 ng/dl (0.24 nmol/liter)]. Data collection took place between March 2001 and April 2002.
All participants gave written informed consent before enrollment, and the Institutional Review Board of the Utrecht University Medical Center approved the study.
Height and weight were measured in the standing position without shoes. Bodymass index (BMI) was calculated as the weight in kilograms divided by the square of the height in meters. Visceral and intraab- dominal fat were assessed using ultrasound measurements (14, 15). Ultrasonography was performed with an HDI 3000 (Philips Medical Systems, Eindhoven, The Netherlands) using a C 4-2 transducer. The distances between the posterior edge of the abdominal muscles and the lumbar spine or psoas muscles were measured using electronic calipers. For all images, the transducer was placed on a straight line drawn between the left and rightmidpoint of lower rib and iliac crest. Distances were measured three times from three different angles: medial, left, and right for intraabdominal fat mass and medial for sc fat mass. Measure- ments were made at the end of quiet expiration, applying minimal pressure without displacement of intraabdominal contents as observed by ultrasound image. Visceral fat wasmeasured as the distance between the skin and the linea alba and intraabdominal fat as the distance be- tween the peritoneum and lumbar spine.
Details on lifestyle and health of the subjects have been published earlier (16).
Fasting blood samples were obtained by venipuncture. Cell-free se- rum was immediately stored at –20 C. T was measured after diethyl extraction using an in-house RIA employing a polyclonal anti-T anti- body (AZG 3290, a gift fromDr. J. J. Pratt, Groningen, The Netherlands). The lower limit of detection of the assay was 0.24 nmol/liter, and interassay variation was 6.0, 5.4, and 8.6% at 2.1, 5.6, and 23 nmol/liter, respectively. SHBGwasmeasured using an immunometric technique on an Immulite analyzer (Diagnostic Products Corp., LosAngeles, CA). The lower limit of detection was 5 nmol/liter, and interassay variation was 6.1, 4.9, and 6.9% at 11.6, 36, and 93 nmol/liter, respectively. E2 was measured after diethylether extraction and Sephadex chromatography using an in-house RIA employing a polyclonal anti-E2 antibody. The lower limit of detection was 20 pmol/liter, and interassay variation was 10 and 3.1% at 81 and 660 pmol/liter, respectively.
Non-SHBG-bound T and E2 were calculated using the method de- scribed by Sodergard et al. (17) using a fixed plasma albumin concen- tration of 40 g/liter. The equations for these calculations are given in Table 1. The association constants we used for the calculation of the binding of T (kt) and E2 (ke) to SHBG were 5.97 � 10
8 and 3.14 � 108, respectively (17). In the literature, various estimates for these binding affinities have been calculated on the basis of various methodologies. Values of 10 � 108 (18), 16 � 108 (2), or 19 � 108 (6) have also been
reported for kt, and values ranging from 3.14 � 10 8 (17) to 6.8 � 108 (2)
have been reported for ke. Changing these constants in the equationswill obviously lead to changes in the calculated levels of unbound hormones and can influence the observed relationships between SHBG and the bioavailable levels of T and E2. Therefore, we repeated the analyses after introducing alternative values for kt and ke in the equations.
All calculations were performed using SPSS 11.0 software. Relations between SHBG and hormone levels were assessed using linear regres- sion for continuous variables described as the linear regression coeffi- cient (�) using SHBG as the independent variable before and after adjustment for age and BMI. Because site-specific differences in aro- matase activity have been described (19), we tested whether adding visceral or abdominal fat mass to the regression analysis had any impact on the results. The linear regression coefficient � indicates the change of the dependent variable for every 1 nmol/liter change in SHBG. Ad- justments for age and BMI were made by adding these parameters as independent variables to the regressionmodel. Adjustments were made because both age and BMI have been shown to be associated with levels of SHBG, T, and E2 in men (13, 16).
The characteristics of the studied men are presented in Table 2. The mean T level was in the eugonadal range. Mean
TABLE 2. Characteristics of the 399 studied men
Characteristic Mean � SD
Age (yr) 60.2 � 11.3 BMI (kg/m2) 26.3 � 3.48 SHBG (�g/dl) 1.01 � 0.36 (40.6 � 14.5) T (ng/dl) 536 � 152 (18.6 � 5.26) Non-SHBG-T (ng/dl) 300 � 75.4 (10.4 � 2.62) E2 (pg/ml) 24.9 � 6.15 (91 � 23) Non-SHBG-E2 (pg/ml) 17.9 � 4.60 (66 � 17) E2 (pg/ml)/T (ng/dl) 0.05 � 0.02 (5.20 � 1.61) Non-SHBG-E2 (pg/ml)/non-SHBG-T (ng/dl)
0.06 � 0.02 (6.57 � 1.94)
Systeme International units are given in parentheses.
TABLE 1. Equations for the calculation of non-SHBG-T and non- SHBG-E2 according to Sodergard et al. (17)
Non-SHBG-T (nmol/liter)
{(kat*[albumin]*[FT])/(1 � kat*[FT])} � [FT]
FT (nmol/liter) {�b � �(b2 � 4a[TT])} /2a, in which a � kat � kt � (kat*kt)([SHBG] � [albumin] � [T]) and b � 1 � kt[SHBG] � kat[albumin] � (kat � kt)[T]
Non-SHBG-E2 (pmol/liter)
[E2] � {ke*[SHBG]*FE2/(1 � ke*[FE2] � kt*[FT])}
FE2 (pmol/liter) {�b � �(b2 � 4ac)}/2a, in which a � (kat*[albumin] � 1)ke, b � ([E2]*ke) � (kae*[albumin] � 1)(1 � kt*[FT]) � (ke*[SHBG]), and c � [E2]*(1 � kt*[FT])
kat, Association constant for binding of T to albumin (4.06*10 4;
liter/mol); kt, association constant for binding of T to SHBG (5.97*10 8;
liter/mol); kae, association constant for binding of E2 to albumin (4.21*104; liter/mol); ke, association constant for binding of E2 to SHBG (3.14*108; liter/mol); [FT], plasma concentration of free (non- albumin-non-SHBGbound)T (mol/liter); [FE2], plasma concentration of free (non-albumin-non-SHBG bound) estradiol (mol/liter); [T], plasma concentration of testosterone (mol/liter); [E2], plasma con- centration of estradiol (mol/liter).
For conversion of (non-SHBG bound)T to ng/dl, multiply by 28.8; for conversion of (non-SHBG-bound) E2 to pg/ml, multiply by 0.27; for conversion of SHBG to �g/dl, multiply by 0.025.
158 J Clin Endocrinol Metab, January 2005, 90(1):157–162 de Ronde et al. • SHGB Is Not an E2 Amplifier
values for abdominal and visceral fat mass as measured by ultrasoundwere 7.52� 2.23 and 2.65� 0.85 cm, respectively. With increasing SHBG concentration, the percentages of
hormone not bound to SHBG decreased from 80 to 36 for T and from 89 to 53 for E2 (Fig. 1). The relationships between SHBG and T and non-SHBG-
bound T (non-SHBG-T) before and after adjustment for age and BMI are presented in Table 3 and in Fig. 2. Higher levels of SHBG were strongly associated with higher levels of T (� � 286 � 15.8; P � 0.001). SHBG and non-SHBG-T were related only after adjustment for age and BMI (� � 32.0 � 9.78; P � 0.001). The relationships between plasma levels of SHBG and E2
andnon-SHBG-E2 are presented inTable 3 and in Fig. 3.High SHBG levels were associated with higher E2 levels (� � 4.47 � 0.90; P � 0.001) but with lower concentrations of non-SHBG-E2 (� � –1.78 � 0.69; P � 0.008). Finally, the relationships between plasma levels of SHBG
and the E2/T ratio and the non-SHBG-E2/non-SHBG-T ratio are presented in Table 3 and Fig. 4. SHBG levels were neg- atively related to both ratios (� � –0.016 � 0.002; P � 0.001 and � � –0.011 � 0.002; P � 0.001, respectively). Adding abdominal or visceral fat mass to the regression analyses did not change the results.
Introducing a kt of 10 � 10 8 into the equations of Table 1
[according to the frequently used Vermeulen method (18)] did not essentially change the relationship between SHBG and non-SHBG-T (�� –2.56� 8.41; P� 0.76 after adjustment for age and BMI). After introducing a ke of 6.8 � 10
8, the inverse relation between SHBG and non-SHBG-E2 was more pronounced (�� –3.76� 0.57; P� 0.001 after adjustment for age and BMI). Only after introducing the highest reported value for kt [19 � 10
8 (6)] and the lowest reported value for ke [3.14 � 10
8 (17)] did the relationship between SHBG and the ratio of non-SHBG-E2/non-SHBG-T appear to be slightly but significantly positive (� � 0.011 � 0.004; P � 0.01 after adjustment for age and BMI). However, it is questionable whether it is allowed to combine these k values, as they were obtained under different circumstances.
In this study, the relationship between SHBG levels and the E2/T ratio was studied in eugonadal healthy men. The concept of SHBG as an estrogen amplifier (6) is based on the observation that with stable T and E2 levels, an increase of SHBG will decrease unbound T more than unbound E2, resulting in an increase of the non-SHBG-E2/non-SHBG-T ratio.However, in eugonadalmen, this theory does not apply because the hypothalamo-pituitary-gonadal (HPG) axis will respond to a decreasing level of non-SHBG-T with an in- crease in LH and T, assuming that non-SHBG-T is driving the feedback inhibition of themale HPG axis. The validity of this hypothesis is supported by our observation that increased levels of SHBG are associated with increased levels of total T but are barely associated with the level of non-SHBG-T. Levels of SHBG show only a modest positive association
with total levels of E2 but are negatively related with those of non-SHBG-E2. As a result, a high concentration of SHBG is associated with a lower (non-SHBG-bound) estrogen/ androgen ratio and vice versa. Endogenous E2 can also have an effect on LH release by the pituitary (20, 21). However, in contrast to T, E2 levels are not directly regulated byHPG axis activity. When bioavailable E2 levels decrease, this might lead to increased LH release by the pituitary with a resulting increase in testicular T production. Total E2 levels will be increased only if T is subsequently aromatized, the extent of which is influenced by parameters such as age and BMI. The regulation of peripheral E2 levels by the HPG axis is indirect and therefore probably not as tight compared with T levels. The fact that an intact HPG axis appears to prevent the
non-SHBG-T concentration to fall with increasing SHBG lev-
FIG. 1. SHBG vs. the percentages of non-SHBG-T (E) and non- SHBG-E2 (F) in 399 men. (For conversion of SHBG to nmol/liter, multiply by 40.)
TABLE 3. Linear regression coefficients (�) for the relationships of SHBG with T, non-SHBG-T, E2, non-SHBG-E2, and estrogen/androgen ratios before and after adjustment for age and BMI
Unadjusted Adjusted for age and BMI
� � SE P � � SE P
T (ng/dl) 252 � 16.8 �0.001 286 � 15.8 �0.001 Non-SHBG-T (ng/dl) 10.2 � 10.4 0.33 32.0 � 9.78 0.001 E2 (pg/ml) 3.22 � 0.84 �0.001 4.47 � 0.90 �0.001 Non-SHBG-E2 (pg/ml) �2.77 � 0.62 �0.001 �1.78 � 0.69 0.008 E2 (pg/ml)/T (ng/dl) �0.016 � 0.002 �0.001 �0.016 � 0.002 �0.001 Non-SHBG-E2 (pg/ml)/non-SHBG-T (ng/dl) �0.011 � 0.002 �0.001 �0.011 � 0.002 �0.001
For �, the result given indicates change of the dependent variable for every 1 �g/dl change in SHBG. For conversion of (non-SHBG-bound) T to nmol/liter, multiply by 0.0347; for conversion of (non-SHBG-bound) E2 to pmol/liter, multiply by 3.67.
de Ronde et al. • SHGB Is Not an E2 Amplifier J Clin Endocrinol Metab, January 2005, 90(1):157–162 159
els makes the in vivo situation in eugonadal men totally different from the in vitro situation where changes in hor- mone binding to SHBG do not evoke adaptations in the HPG axis. This lack of similarity between in vivo and in vitro conditions was already alluded to by Rosner (22) but, to our knowledge, was never formally tested. Our findings in healthy men seem to conflict with condi-
tions associated with high SHBG levels in men such as ad- vanced age, liver disease, hyperthyroidism, and estrogen administration (22). These conditions are associated with increased estrogen/androgen ratios and gynecomastia (23, 24), and they seem to confirm the concept of SHBG as an estrogen amplifier. However, besides the altered SHBG lev-
els, these conditions are also associated with altered gonadal function. Hypogonadism is frequently observed in liver cir- rhosis patients (25, 26). In hyperthyroid men, lower levels of non-SHBG-T are frequently (7–9) but not always (27, 28) reported, which suggests that the HPG axis in these men is not always able to fully compensate for the rise in SHBG concentration. Moreover, the increased estrogen/androgen ratio in hyperthyroid subjects might be caused by increased androgen aromatization (10, 29). The age-associated increase in SHBG is not associated with an increase in T levels (30), which suggests that the HPG axis of older men is not capable of responding to a fall in T levels. Therefore, it is likely that the relative hypogonadism and not the increased SHBG per
FIG. 2. SHBG vs. T (left) and non-SHBG-T (right) in 399 men. The relationship between SHBG and T is given by the formula [T] � 280 � 252[SHBG] and that between SHBG and non-SHBG-T by [non-SHBG-T] � 290 � 10.2[SHBG]. [For conversion of (non-SHBG-bound) T to nmol/liter, multiply by 0.0347; for conversion of SHBG to nmol/liter, multiply by 40.]
FIG. 3. SHBG vs. E2 (left) and non-SHBG-E2 (right) in 399 men The relationship between SHBG and E2 is given by the formula [E2] � 21.6 � 3.22[SHBG] and that between SHBG and non-SHBG-E2 by [non-SHBG-E2] � 20.7 –2.77[SHBG]. [For conversion of (non-SHBG-bound) E2 to pmol/liter, multiply by 3.67; for conversion of SHBG to nmol/liter, multiply by 40.]
se may explain the high estrogen/androgen ratio in these men. The question of the clinical relevance of our observation
arises. In the pathogenesis of gynecomastia, a high estrogen/ androgen balance seems to be of importance (23, 24). Ac- cording to our results, men with low levels of SHBG and a resulting high estrogen/androgen ratio would have a higher risk of developing gynecomastia, although this association has not been reported in the literature. Probably the changes in the estrogen/androgen ratio brought about by SHBG in eugonadal men are too subtle to cause gynecomastia. Our results show that high levels of SHBG are associated
with lower levels of non-SHBG-E2 but normal or even slightly higher levels of non-SHBG-T. The decreased feed- back inhibition of non-SHBG-E2 on the release of LH by the pituitary probably explains the slightly positive relationship between levels of non-SHBG-T and SHBG. It is well known that lower levels of non-SHBG-E2 in men
are associated with lower bone mineral density (31, 32). Ap- parently, even in eugonadal men, elevated SHBG levels might contribute to estrogen deficiency and to conditions such as osteoporosis. One might speculate that while passing through capillar-
ies, a proportion of the bound hormone dissociates from SHBG and in fact becomes bioavailable. In that case, the amount of bioavailable hormone might be underestimated when using the described equations for the calculation of the bioavailable fractions. Consequently, the amount of bioavail- able E2 would be underestimated more in comparison with the amount of bioavailable T because of the weaker binding of E2 to SHBG. However, the validity of this hypothesis remains to be determined. For the calculation of the levels of non-SHBG-E2 and non-
SHBG-T we used the equations as described by Sodergard et al. (Table 1) (17) in which the association constants for the
binding of T (kt) andE2 (ke) to SHBGare 5.97� 10 8 and 3.14�
108, respectively. In the literature, alternative estimates for these binding affinities are reported (2, 6, 18). Use of a higher association constant in the equation will tilt the slope of the regression lines shown in Figs. 2 and 3 (right panels) slightly down and vice versa. Theoretically, combining a high kt with a low ke in the equations of Table 1 can result in a positive relation between SHBG and the non-SHBG-E2/non-SHBG-T ratio. However, when the combination of values as reported byDunn et al. (2) and Burke andAnderson (6) were used, this was not the case. Although the subjects we studied were prone to health
selection bias, this does not undermine the conclusions of this study. In fact, it contributed to the uniformity of the analyses because there were only a few hypogonadal subjects (based on T and non-SHBG-T levels) in this group of men. On the other hand, it prevented us from doing separate analyses on data from eugonadal and hypogonadal men. The conclusion of our study is that in eugonadal men,
higher SHBG levels are associated with lower levels of non- SHBG-E2 but unaltered or even slightly higher levels of non-SHBG-T. This means that SHBG cannot be regarded as an estrogen amplifier in eugonadal men.
Received March 2, 2004. Accepted October 18, 2004. Address all correspondence and requests for reprints to: Frank H. de
Jong, Ph.D., Endocrine Laboratory, RoomEe 516, Department of Internal Medicine, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Neth- erlands. E-mail: f.h.dejong@erasmusmc.nl.
1. Kahn SM, Hryb DJ, Nakhla AM, Romas NA, Rosner W 2002 Sex hormone- binding globulin is synthesized in target cells. J Endocrinol 175:113–120
2. Dunn JF, Nisula BC, Rodbard D 1981 Transport of steroid hormones: binding
FIG. 4. SHBG vs. the ratio of E2 over T (left) and the ratio of non-SHBG-E2 over non-SHBG-T (right) in 399 men. The relationship between SHBG and E2/T ratio is given by the formula E2/T � 0.066 –0.016[SHBG] and that between SHBG and non-SHBG-E2 by non-SHBG-E2/ non-SHBG-T� 0.074 –0.011[SHBG]. (For conversion of T to nmol/liter, multiply by 0.0347; for conversion of E2 to pmol/liter, multiply by 3.67; for conversion of SHBG to nmol/liter, multiply by 40.)
of 21 endogenous steroids to both testosterone-binding globulin and cortico- steroid-binding globulin in human plasma. J Clin Endocrinol Metab 53:58–68
3. Vermeulen A, Ando S 1979 Metabolic clearance rate and interconversion of androgens and the influence of the free androgen fraction. J Clin Endocrinol Metab 48:320–326
4. Mendel CM 1989 The free hormone hypothesis: a physiologically basedmath- ematical model. Endocr Rev 10:232–274
5. RosnerW 1991 Plasma steroid-binding proteins. EndocrinolMetab Clin North Am 20:697–720
6. Burke CW, Anderson DC 1972 Sex-hormone-binding globulin is an oestrogen amplifier. Nature 240:38–40
7. Ford HC, Cooke RR, Keightley EA, Feek CM 1992 Serum levels of free and bound testosterone in hyperthyroidism. Clin Endocrinol (Oxf) 36:187–192
8. Garden GA, Hannan CJ, Spencer CA, Plymate SR 1988 The effect of sex hormone binding globulin (SHBG) on the pituitary testicular axis in hyper- thyroid men. Steroids 52:385–386
9. Abalovich M, Levalle O, Hermes R, Scaglia H, Aranda C, Zylbersztein C, Oneto A, Aquilano D, Gutierrez S 1999 Hypothalamic-pituitary-testicular axis and seminal parameters in hyperthyroid males. Thyroid 9:857–863
10. Ruder H, Corvol P, Mahoudeau JA, Ross GT, Lipsett MB 1971 Effects of induced hyperthyroidism on steroid metabolism in man. J Clin Endocrinol Metab 33:382–387
11. Ridgway EC, Longcope C, Maloof F 1975 Metabolic clearance and blood production rates of estradiol in hyperthyroidism. J Clin Endocrinol Metab 41:491–497
12. Ridgway EC, Maloof F, Longcope C 1982 Androgen and oestrogen dynamics in hyperthyroidism. J Endocrinol 95:105–115
13. Vermeulen A, Kaufman JM, Giagulli VA 1996 Influence of some biological indexes on sex hormone-binding globulin and androgen levels in aging or obese males. J Clin Endocrinol Metab 81:1821–1826
14. Stolk RP, Wink O, Zelissen PM, Meijer R, van Gils AP, Grobbee DE 2001 Validity and reproducibility of ultrasonography for the measurement of intra- abdominal adipose tissue. Int J Obes Relat Metab Disord 25:1346–1351
15. Tornaghi G, Raiteri R, Pozzato C, Rispoli A, Bramani M, Cipolat M, Craveri A 1994 Anthropometric or ultrasonic measurements in assessment of visceral fat? A comparative study. Int J Obes Relat Metab Disord 18:771–775
16. Muller M, den Tonkelaar I, Thijssen JH, Grobbee DE, van der Schouw YT 2003 Endogenous sex hormones in men aged 40–80 years. Eur J Endocrinol 149:583–589
17. Sodergard R, Backstrom T, Shanbhag V, Carstensen H 1982 Calculation of free and bound fractions of testosterone and estradiol-17� to human plasma proteins at body temperature. J Steroid Biochem 16:801–810
18. Vermeulen A, Verdonck L, Kaufman JM 1999 A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 84:3666–3672
19. McTernan PG, Anderson LA, Anwar AJ, Eggo MC, Crocker J, Barnett AH, Stewart PM, Kumar S 2002 Glucocorticoid regulation of p450 aromatase activity in human adipose tissue: gender and site differences. J Clin Endocrinol Metab 87:1327–1336
20. Finkelstein JS, O'Dea LS, Whitcomb RW, Crowley Jr WF 1991 Sex steroid control of gonadotropin secretion in the human male. II. Effects of estradiol administration in normal and gonadotropin-releasing hormone-deficientmen. J Clin Endocrinol Metab 73:621–628
21. Hayes FJ, Seminara SB, Decruz S, Boepple PA, Crowley Jr WF 2000 Aro- matase inhibition in the human male reveals a hypothalamic site of estrogen feedback. J Clin Endocrinol Metab 85:3027–3035
22. Rosner W 1990 The functions of corticosteroid-binding globulin and sex hormone-binding globulin: recent advances. Endocr Rev 11:80–91
23. Ismail AA, Barth JH 2001 Endocrinology of gynaecomastia. AnnClin Biochem 38:596–607
24. Glass AR 1994 Gynecomastia. Endocrinol Metab Clin North Am 23:825–837 25. Pignata S, Daniele B, Galati MG, Esposito G, Vallone P, Fiore F, Ricchi P,
Pergola M 1997 Oestradiol and testosterone blood levels in patients with viral cirrhosis and hepatocellular carcinoma. Eur J Gastroenterol Hepatol 9:283–286
26. NagasueN,OgawaY, YukayaH,OhtaN, Ito A 1985 Serum levels of estrogens and testosterone in cirrhotic men with and without hepatocellular carcinoma. Gastroenterology 88:768–772
27. Hudson RW, Edwards AL 1992 Testicular function in hyperthyroidism. J Androl 13:117–124
28. Kidd GS, Glass AR, Vigersky RA 1979 The hypothalamic-pituitary-testicular axis in thyrotoxicosis. J Clin Endocrinol Metab 48:798–802
29. Chopra IJ 1975 Gonadal steroids and gonadotropins in hyperthyroidism. Med Clin North Am 59:1109–1121
30. Vermeulen A 1991 Androgens in the aging male. J Clin Endocrinol Metab 73:221–224
31. van den Beld AW, de Jong FH, Grobbee DE, Pols HA, Lamberts SW 2000 Measures of bioavailable serum testosterone and estradiol and their relation- ships with muscle strength, bone density, and body composition in elderly men. J Clin Endocrinol Metab 85:3276–3282
32. Szulc P, Munoz F, Claustrat B, Garnero P, Marchand F, Duboeuf F, Delmas PD 2001 Bioavailable estradiol may be an important determinant of osteopo- rosis in men: the MINOS study. J Clin Endocrinol Metab 86:192–199
JCEM is published monthly by The Endocrine Society (http://www.endo-society.org), the foremost professional society serving the endocrine community.
Script para adicionar à lista
Script para remover à lista
Script para submeter tags e comentários
Script para partilhar no Facebook


text:
from __future__ import print_function
import os
import sys

__fileNames = [
	os.path.join(os.path.realpath(__file__).rstrip(os.path.basename(__file__)), '..', 'config.yaml'),
	'/etc/opt/AlexaPi/config.yaml',
]

filename = ''
for fn in __fileNames:
	if os.path.isfile(fn):
		filename = fn
		break

if filename == '':
	print('ERROR: No configuration file found!')
	sys.exit(1)

def set_variable(variable, value):
	# WARNING: this is a silly implementation that doesn't care about YAML sections,
	# therefore a unique variable name is needed for now
	variable = variable[-1]

	lines = []
	with open(filename, 'r') as stream:
		for line in stream:
			strip = line.lstrip()
			if strip.startswith(variable):
				lines.append(line[0:line.find(strip)] + variable + ': "' + value + '"\n')
			else:
				lines.append(line)

	with open(filename, 'w') as stream:
		stream.writelines(lines)


Last year I only published three blog posts; the year before was not much better, with a period of inactivity that spanned almost half the year, followed by occasional attempts to catch up, which had come to mean writing from the backlog, picking the most memorable and notable things that had happened, mostly about our various travels. I enjoy our trips immensely and want to have a permanent written record of them. In the past two years we have gone all over the world, have seen so many beautiful things, and had so many beautiful experiences. I want to have a written record of what has happened, to stir our memories in the distant future. I love the writing process, the space for reflection, but there was something about the state I had arrived at that sapped my motivation and lowered it below the necessary activation threshold, especially with other goals (e.g. working out) that had become a higher priority.
For writing to be a part of my daily routine, I need it to be therapeutic, to regenerate my strength instead of sappping it. I need to put down in words the things that I am thinking about in the moment that I am sitting at the keyboard, instead of having to make the effort to recall and reconstruct events from my memory. I hope that as I return to this approach, there will be times when I am pondering the events that occurred during this blog's fallow period. I am inspired by two very different sources. Matthew Dicks recommends that aspiring storytellers spend five minutes every day trying to understand what happened that day that was part of a great story. Henry B. Eyring was inspired to keep a journal of the ways that he "had seen the hand of God blessing our family." There is a difference between what I need to write, and what I want to have written. In any frame of reference, learning to put needs ahead of wants is an important lesson.


text:
Envision Pharma acquires ProScribe
Posted by Kimberly Henneberg on February 5, 2014 . -- Press Release
Halifax-backed Envision Pharma expands into Asia-Pacific via ProScribe Acquisition
WASHINGTON, DC & HORSHAM, UK – February 5, 2014 – Envision Pharma Group, a global technology and scientific communication company, announced today that it has acquired Queensland, Australia-based ProScribe, a medical writing company. The acquisition will be Envision's first in the Asia-Pacific region. Terms of the transaction were not disclosed. The Halifax Group ("Halifax"), a leading private equity firm, initially partnered with Envision Pharma and its management team in June 2013.
ProScribe is a specialty medical writing company with offices in Australia, China and Japan, providing services to academia, biopharma, and medical device companies . ProScribe takes a leadership role in championing the need for ethical, transparent data dissemination within the Asia-Pacific region and beyond.
Envision Pharma is focused on the pharmaceutical, biotechnology and medical device industries. Along with Envision, Evidence, Excel and Engage, ProScribe will operate as the fifth Scientific Solutions division within the Envision Pharma Group. ProScribe founders Professor Karen Woolley and Dr. Mark Woolley will join the senior management team of Envision and continue to lead ProScribe's dedicated team of medical writers, all of whom are exceptionally well versed in the complex, and often culturally sensitive, environment in which they operate.
Envision co-founder Brian Hepburn remarked, "We are pleased to partner with Professor and Dr. Woolley and their outstanding team. The addition of ProScribe expands our presence and capability within the Asia-Pacific region, and in concert with our existing offices, gives the Envision Pharma Group dedicated resources on three continents, enabling us to provide a truly global service that mirrors our clients' needs in today's environment."
"We found the right partner in EnvisionPharma. The synergy between ProScribe and Envision means that we have created an industry-leading global service group that is unrivalled in terms of scientific knowledge and expertise, regulatory and compliance understanding, ethical publication practices, and industry insight," commented Professor Woolley.
Halifax principal Scott Plumridge added, "We fully appreciate the global nature of the pharmaceutical and biotechnology industry and the strategic importance of the Asia-Pacific region. ProScribe's talented team has developed an enviable position within the scientific communications market, and we are thrilled to have them join the Envision platform."
About Envision Pharma
Founded in 2001, Envision Pharma Group is an innovative global technology and scientific communication company serving pharmaceutical, biotechnology, and medical device companies. Envision offers a unique blend of solutions including strategic publication planning and related data dissemination and consultancy services, enhanced with industry-leading complementary technology solutions. Envision has 5 offices, 2 in the United Kingdom and 3 in the United States. The company now has over 300 team members, including over 145 highly qualified and experienced in-house medical writers and a 55-strong technology solutions team providing platform development and customer support. Envision continues today under the stewardship of the core management team that formed the company in 2001.
The Halifax Group is a private equity firm that partners with managers and entrepreneurs to recapitalize and grow lower middle-market businesses across a variety of industries including health and wellness, infrastructure, business and government services and franchising. The firm maintains offices in Washington, D.C.; Dallas, TX; and Raleigh, NC. For more information, please visit www.thehalifaxgroup.com.


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Froy Gutierrez Wiki: Nationality, Age, Parents, Siblings, Girlfriend, Dating
You rarely find a good-looking and talented guy to be single these days. One of those rare actors is The MTV hit series "Teen Wolf" star, Froy Gutierrez. He is one of the phenomenal and gorgeous actors in Hollywood who marked his success from just a mere stage actor to a heart throbbing megastar within a short period. He now has managed to win millions of hearts from the movies and television series he has starred.
Date of Birth Apr 27, 1998
Social Media Instagram, Twitter
Height 5 Feet 10 Inches (178 cm)
Education Booker T. Washington High School
Siblings One Sister & One Brother
You rarely find a good-looking and talented guy to be single these days. One of those rare actors is The MTV hit series "Teen Wolf" star, Froy Gutierrez. He is one of the phenomenal and gorgeous actors in Hollywood who marked his success from just a mere stage actor to a heart throbbing megastar within a short period. He now has managed to win millions of souls from the movies and television series he has starred.
The Journey from a Stage Actor to a Hollywood Heartthrob:
If you are a fan of the Nickelodeon series, "Bella and the Bulldogs," you are sure to love the character, Charlie. Well, Charlie is the role played by Froy Gutierrez who guest starred on the show. Charlie also appeared in the ABC's "The Goldbergs" as a guest. He then worked in plays such as "Little Woman" and "The Match Maker."
The guest role he played in shows made female fans fall for him but the character of Nolan he played in the hit MTV television show, "Teen Wolf" left them awe-struck! He joined the Teen Wolf pack for season 6B in 2017. He, in an interview with Hollywood Life on April 14, 2017, spilled that he was very excited to be a part of the show and it has been a fantastic experience for him.
Froy, apart from his roles in films and TV series has worked in commercials as well. He contributed to ads for, "AT&T," "Hasbro," "Boys Scouts of America" and "Build a Bear."
Is Froy Gutierrez Single?
It would come out to be a surprise if the hot and sexy guy as Froy Gutierrez is single. But then again it would come out to be a heartbreak if he is dating someone. His female fans who go head over heels for him would definitely feel jealous but eventually would be happy for him. So what is his current relationship status? Does he have a girlfriend? Let's dig in deeper.
The "Teen Wolf" megastar, Froy has engraved himself into thousands of his audience. But it looks like he has not yet found the girl of his dreams. The Mexican star is a bit of an introvert who is all about maintaining his personal space. Despite his popularity, no sources have any idea about his past as well as his present relationship affair.
Gutierrez who has 1.2 million followers on Instagram and 181k followers on twitter share his precious moments to his fans through his posts and tweets. However, it seems like he keeps the information about his girlfriend up close and personal and does not want people to know about it yet.
Nevertheless, he has shared love affairs onscreen with his co-actors. One of his famous roles the one where he plays a love interest of "Bella" played by Brec Bassinger in "Bella and the Bulldogs."
Caption: Froy with his onscreen girlfriend, Brec Bassinger(Bella), published 1st December 2015
Source: J-14
Short Bio on Froy Gutierrez
Froy Gutierrez was born on April 27, 1998, in Dallas, Texas. Currently, aged 19, Froy graduated in Theater for the Performing Arts at Booker T. Washington. As he is a very reserved person, he has not disclosed information about his parents. According to the wiki sources, he is an older child among the three siblings. The Teen Wolf star is American by Nationality and belongs to white ethnicity.


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[Op-Ed] Year of the Formidable Tiger China?
[Op-Ed] Year of the Formidable Tiger China?. January. 02, 2010 08:38. .
Chinese President Hu Jintao in his New Year address Friday pledged to achieve qualitative economic growth through active fiscal measures and appropriate financial policies. He also emphasized the importance of global cooperation to deal with the economic crisis. In particular, Hu said the objective of China's diplomacy is to achieve global peace and grow together with other countries, adding Beijing will consistently take the path of peaceful development. The Japanese media network NHK said Hu's speech aimed to win over the international community, which is increasingly worried over China's growing influence on the global stage. Beijing is taking the leading role in helping the world economy recover from the global economic crisis, lifting itself from the downturn faster than any other country.
The International Monetary Fund projected last year that the world economy would decline 1.1 percent and that the economies of 30 member centuries of the Organization for Economic Cooperation and Development would contract an average 3.4 percent. The U.S. economy declined 2.7 percent, Japan's 5.4 percent, and the European Union's 4.2 percent. By contrast, China's national information center forecast its economy would grow 8.5 percent last year. Its GDP is expected this year to be the world's second largest, overtaking Japan's.
In 1985, the U.S. signed an agreement with Japan and Germany forcing them to appreciate their currencies to reduce the U.S. current account deficit. The Plaza Agreement, the U.S.-led coordination system of the global economy, is no longer effective, however, due to China's rapid rise. Though Washington has repeatedly urged Beijing to appreciate its currency yuan to reduce their trade deficit, China has declined, saying the problem lies in the excessive consumption of the American people. Unlike the Group of Seven, which brings together the seven major economies committed to democracy and market economics, the G2, referring to the U.S. and China, is unstable since both sides have common and conflicting interests.
Korea began pursuing export-driven economic development in the early 1960s ahead of China. Taking advantage of its head start and the political turmoil stemming from China's Cultural Revolution of the 1960s and 1970s, Korea became a wealthier country than China. Things are dramatically changing due to China's rapid growth, however. If Korea fails to wisely respond to the effects of China's emergence, the economy will greatly suffer. The Korean government should remain vigilant and accurately read changes in China.
Editorial Writer Kwon Soon-hwal (shkwon@donga.com)
W재단 "유엔기후변화협약 뉴스레터 통해 HOOXI 캠페인 전 세계에 소개"


text:
local S = factory.S
minetest.register_craftitem("factory:small_steel_gear", {
	description = S("Small Steel Gear"),
	inventory_image = "factory_small_steel_gear.png"
})

minetest.register_craftitem("factory:small_gold_gear", {
	description = S("Small Gold Gear"),
	inventory_image = "factory_small_gold_gear.png"
})

minetest.register_craftitem("factory:small_diamond_gear", {
	description = S("Small Diamond Gear"),
	inventory_image = "factory_small_diamond_gear.png"
})


The human body is an awesomely complicated and interconnected system. Pain in one location of the body can spread out in waves, affecting other parts. It's important to understand not only where the pain comes from, but why it's occurring and what the best long-term treatment method is.
When it comes to issues like scoliosis, disc lesions, or even lower back pain, it's important to integrate the best aspects from multiple disciplines in order to create the ideal treatment plan. At Progressive Health and Rehab, we believe in combining the best of chiropractic treatment, physical therapy, and cutting-edge equipment in order to perform spinal rehabilitation.
Your spine and spinal cord are the control center of the rest of your body. For those with disc damage, our spinal rehabilitation may include a disc decompression procedure where the damaged disc tissue is rehydrated and nutrients are pumped in. For those with damaged ligaments, our vibrational machine may be utilized to cycle nutrition into damaged white tissue which helps it to regain strength. As pain decreases, physical therapy may be administered to help strengthen damaged soft tissue.
If your doctor has recommended surgery or prescription drugs, but you don't feel comfortable with it, contact us. We can help you to avoid drastic or irreversible measures, and greatly improve your well being.
Please contact us today to schedule an initial consultation!


text:
/ Rob Larkin & The Wayward Ones release "Dogwood Roots"
Rob Larkin & The Wayward Ones release "Dogwood Roots"
Dustin 25 February 2014
Artist: Rob Larkin & The Wayward Ones
Album: Dogwood Roots
Rating: 4/5 Stars
URL: www.roblarkinmusic.com
Today I listened to the 10 Track CD by Orange County based Rob Larkin & The Wayward Ones called "Dogwood Roots (Specra Records). Rob Larkin is one artist that cannot and should not be underscored. All music, lyrics, and fretwork invites the listener to sift through a multitude of folk-pop-rock sounds, all of which congeal up a tangible yet gorgeous selection of songs – 10 of them in fact. It's all kicked off by the tasty "Dogwood" which when you listen to the piece is the perfect intro statement to start a musical journey with. There's somewhat of an upbeat, hopeful tone and mood here when one is introduced to this amazing band and Larkin's soulful voice for the first time via this intro track. Larkin's voice is mostly well suited for pop. I have to admit when I saw the pictures of these guys and after listening to this first song – this band was everything I imagined them to be. On "Dogwood Roots" we hear music reflecting the many tongue and cheek offerings provided by past bands like John Mayer, The Michael Stanley Band, The Wood Brothers, The Script, Mathcbox 20, McFly and The 1975. I see this music as mostly Acoustic Pop. This proves to be a very well grounded environment for this collection of songs. Pieces like 'Dogwood", "TLA" and Spills Out"
Despite this Larkin branches off with other tracks like rocking "Tijuana" and my personal favorite "One Rise Up." Artistic expression should never be held to a strict guideline of musical fundamentalism. I hate to use that word "fundamentalism" here but that's the way it feels sometime when we try to categorize artists. Performance based bands like Rob Larkin sad to say are a dying breed as most good bands have been replaced by what I would call sonic garbage. I also don't think "musical fundamentalism" is what traditional Rock n' Roll is about, and yes this album is fundamentally rock based. Having said this "Dogwood Roots" is in a league of its own combining the best modern acoustic pop has to offer. Though these guys are based in LA they could most certainly pull it off in a place like Austin or Nashville. The musicianship is off the charts, the songs are amazing and the catalogue is fully loaded.
"Dogwood Roots" is a strong and epic album. It also refuses to fall into the trap of becoming fundamentally duress-ridden pop. The musical arrangements really differ from song to song and the vocals and emotional latitude tend to remain compatible with that versatility of the artist. All at a constant level throughout. Its music that you could use to watch the clouds go by – but also make you want to jump up, grab your guitar and write a powerful song that could change peoples lives. To inspire someone in on a very sincere and powerful level – yeah that what music is all about?
FACEBOOK: https://www.facebook.com/roblarkinmusic
by Amanda Pearson edited by Markus Druery
Review comments: marktheshark972@gmail.com


Over the last few months we've seen a significant rise in student activism at British universities. Prompted by the anti-privatisation 'Occupy Sussex' protest, students around the country have sought to influence the managers of their institutions in increasingly visible ways.
Last week saw students at my own university occupy one of Warwick's prominent administrative buildings, Senate House. The protesters complained of a 'marketisation' of the university – a process epitomised by the Vice Chancellor's recent pay rise of £42,000 at a time when less well paid staff fear for their jobs.
I discussed the protest with a number of students and it is fair to say that whilst the activists garnered considerable support from their peers, they were also met with cynicism. It was hard to find students who believed that the university should be run more like a business but a far more common criticism of the protest was that it simply wouldn't change anything.
My immediate response to this criticism was perhaps the obvious one. If it weren't for their visible occupation of the university, we wouldn't have have been talking about the issues the protesters wanted to see addressed. A discussion or debate in some SU meeting room or lecture hall would not have so effectively encouraged students and staff to engage with the ongoing transformation of Warwick University and higher education general. In that sense, the occupation very efficiently bought about change – it got people talking.
But the occupation of Senate House has now come to an end. The university refused to constructively engage with the protesters and claimed that their concerns would only be addressed through the officially sanctioned channel of democracy, the Students Union. Critics will now accuse activists of achieving nothing and only wasting time. Their efforts, it will be argued would have been more fruitful had they worked more closely with the university and union.
Apart from the fact that many of the protesters are active in student politics, this response overlooks something rather more important. Radical change rarely comes from the beneficence of the powers-that-be, it comes from visible grassroots activism. This is why student protest is so important. Many feel disenfranchised by the existing channels of engagement and protest provides them with a more direct way to air widely-held grievances.
Were it not for the activists of the past that pushed against rules and regulations to get their voices heard, there would be no union for the university to refer protesters to. Increased representation has historically been the result of precisely this kind of action.
Although the university refused to engage with the protesters on this occasion, this does not mean that in future protests they will not have to. Activism has seldom been met with open arms. Protests like the one at Warwick attempt to open a new dialogue with management on students' terms. At a time when so many feel frustrated and ignored, that should only be encouraged. If cynics ever want to see a day when something can change, they must stop writing student protest off.