Alaska and subarctic Canada southeast of the Rocky Mountains to central Texas; east to New England and central Florida. Isolated populations in Arizona, New Mexico, and west Texas south into Mexico. The Red-spotted Purple is usually found south of this line. Much hybridization occurs where these forms meet.
The white band is a recessive trait. It could potentially occur in any population. Both forms interbreed where their ranges overlap producing intergrades with partial bands. The Red-spotted Purple has a more southern range, and is a Batesian mimic of the Pipevine Swallowtail. Males perch 3 feet or more above the ground on trees and tall bushes and rarely patrol for females. Eggs are laid singly on tips of hostplant leaves; caterpillars eat leaves. Third instar larvae overwinter.
Upperside is blue to blue-green with much iridescence on the outer part of the hindwing. Underside is dark brown. Forewing has 2 red-orange bars near the base of the leading edge; hindwing has 3 red-orange spots near the base and a submarginal row of red-orange spots. The two forms hybridize where their ranges overlap, creating various intermediate forms which may be found in or near the overlap zone.
Flight periods of both forms overlap. Both appear to have a smaller second generation in August. White Admiral can be incredibly abundant in late June and early July. Extreme dates: Red-spotted Purple – 17 May 2003 in Weybridge (D. Peterson) and 25 August 2002 in Chester (M. Reiter). White Admiral – 24 May 2004 in Pownal (K. Hemeon) and 1 October 2002 in South Burlington.
Red-spotted Purples were found primarily in southern half of Vermont. Hostplants are the leaves of many species of deciduous trees and shrubs. Adults feed from sap flows, rotting fruit, carrion, dung, and occasionally nectar from small white flowers. White Admirals also sip aphid honeydew.


text:
<?php
App::uses('AppController', 'Controller');
/**
 * Badges Controller
 *
 * @property Badge $Badge
 * @property PaginatorComponent $Paginator
 * @property SessionComponent $Session
 */
class BadgesController extends AppController {

/**
 * Components
 *
 * @var array
 */
	public $components = array('Paginator', 'Session');

/**
 * index method
 *
 * @return void
 */
	public function index() {
		$this->Badge->recursive = 0;
		$this->set('badges', $this->Paginator->paginate());
	}

/**
 * view method
 *
 * @throws NotFoundException
 * @param string $id
 * @return void
 */
	public function view($id = null) {
		if (!$this->Badge->exists($id)) {
			throw new NotFoundException(__('Invalid badge'));
		}
		$options = array('conditions' => array('Badge.' . $this->Badge->primaryKey => $id));
		$this->set('badge', $this->Badge->find('first', $options));
	}

/**
 * add method
 *
 * @return void
 */
	public function add() {
		if ($this->request->is('post')) {
			$this->Badge->create();
			if ($this->Badge->save($this->request->data)) {
				$this->Session->setFlash(__('The badge has been saved.'));
				return $this->redirect(array('action' => 'index'));
			} else {
				$this->Session->setFlash(__('The badge could not be saved. Please, try again.'));
			}
		}
		$users = $this->Badge->User->find('list');
		$this->set(compact('users'));
	}

/**
 * edit method
 *
 * @throws NotFoundException
 * @param string $id
 * @return void
 */
	public function edit($id = null) {
		if (!$this->Badge->exists($id)) {
			throw new NotFoundException(__('Invalid badge'));
		}
		if ($this->request->is(array('post', 'put'))) {
			if ($this->Badge->save($this->request->data)) {
				$this->Session->setFlash(__('The badge has been saved.'));
				return $this->redirect(array('action' => 'index'));
			} else {
				$this->Session->setFlash(__('The badge could not be saved. Please, try again.'));
			}
		} else {
			$options = array('conditions' => array('Badge.' . $this->Badge->primaryKey => $id));
			$this->request->data = $this->Badge->find('first', $options);
		}
		$users = $this->Badge->User->find('list');
		$this->set(compact('users'));
	}

/**
 * delete method
 *
 * @throws NotFoundException
 * @param string $id
 * @return void
 */
	public function delete($id = null) {
		$this->Badge->id = $id;
		if (!$this->Badge->exists()) {
			throw new NotFoundException(__('Invalid badge'));
		}
		$this->request->onlyAllow('post', 'delete');
		if ($this->Badge->delete()) {
			$this->Session->setFlash(__('The badge has been deleted.'));
		} else {
			$this->Session->setFlash(__('The badge could not be deleted. Please, try again.'));
		}
		return $this->redirect(array('action' => 'index'));
	}

/**
 * admin_index method
 *
 * @return void
 */
	public function admin_index() {
		$this->Badge->recursive = 0;
		$this->set('badges', $this->Paginator->paginate());
	}

/**
 * admin_view method
 *
 * @throws NotFoundException
 * @param string $id
 * @return void
 */
	public function admin_view($id = null) {
		if (!$this->Badge->exists($id)) {
			throw new NotFoundException(__('Invalid badge'));
		}
		$options = array('conditions' => array('Badge.' . $this->Badge->primaryKey => $id));
		$this->set('badge', $this->Badge->find('first', $options));
	}

/**
 * admin_add method
 *
 * @return void
 */
	public function admin_add() {
		if ($this->request->is('post')) {
			$this->Badge->create();
			if ($this->Badge->save($this->request->data)) {
				$this->Session->setFlash(__('The badge has been saved.'));
				return $this->redirect(array('action' => 'index'));
			} else {
				$this->Session->setFlash(__('The badge could not be saved. Please, try again.'));
			}
		}
		$users = $this->Badge->User->find('list');
		$this->set(compact('users'));
	}

/**
 * admin_edit method
 *
 * @throws NotFoundException
 * @param string $id
 * @return void
 */
	public function admin_edit($id = null) {
		if (!$this->Badge->exists($id)) {
			throw new NotFoundException(__('Invalid badge'));
		}
		if ($this->request->is(array('post', 'put'))) {
			if ($this->Badge->save($this->request->data)) {
				$this->Session->setFlash(__('The badge has been saved.'));
				return $this->redirect(array('action' => 'index'));
			} else {
				$this->Session->setFlash(__('The badge could not be saved. Please, try again.'));
			}
		} else {
			$options = array('conditions' => array('Badge.' . $this->Badge->primaryKey => $id));
			$this->request->data = $this->Badge->find('first', $options);
		}
		$users = $this->Badge->User->find('list');
		$this->set(compact('users'));
	}

/**
 * admin_delete method
 *
 * @throws NotFoundException
 * @param string $id
 * @return void
 */
	public function admin_delete($id = null) {
		$this->Badge->id = $id;
		if (!$this->Badge->exists()) {
			throw new NotFoundException(__('Invalid badge'));
		}
		$this->request->onlyAllow('post', 'delete');
		if ($this->Badge->delete()) {
			$this->Session->setFlash(__('The badge has been deleted.'));
		} else {
			$this->Session->setFlash(__('The badge could not be deleted. Please, try again.'));
		}
		return $this->redirect(array('action' => 'index'));
	}
}

redpajama_set_name: RedPajamaGithub


text:
7 Beautiful and Historic Churches in Philadelphia Worth Visiting
October 10, 2022 September 23, 2015 by Jim Cheney
Given Philadelphia's status as the most important city in the birth of America, it's not surprising that the city was also a focal point for religious life in the young country. Fortunately, many of these historic churches have managed to stay alive into the 21st century and have managed to both retain congregations and keep much of the historical features that made them special.
These buildings span a variety of denominations but all have a beauty and history that's hard to find anywhere else in the country.
So, the next time you are in Philadelphia, here are seven churches, all located in or relatively close to Philadelphia's Old City, that you should make a point to check out:
Cathedral Basilica of Saints Peter and Paul
The beautiful interior of the Cathedral Basilica of Saints Peter and Paul.
The Cathedral Basilica of Saints Peter and Paul is one of the most beautiful churches that you'll find anywhere in the country. Completed in 1864, the cathedral is the head church of the Roman Catholic Archdiocese of Philadelphia and is the largest Catholic church in the state.
Outside, the largest brownstone facade in Philadelphia gives the cathedral a unique look, but inside, it invokes some of the most majestic cathedrals of Europe. The cathedral has beautiful stained glass windows, and many of the striking murals in the church were painted by Constantino Brumidi, who later went on to paint the rotunda of the US Capitol in Washington DC.
The unique exterior of the Cathedral Basilica of Saints Peter and Paul on Logan Square in Philadelphia.
As the main cathedral of the Catholic church in Philadelphia, the cathedral welcomed Pope John Paul II in 1979 and will welcome Pope Francis this month.
For more information, check out my full article with information about visiting the Cathedral Basilica of Saints Peter and Paul.
The Cathedral Basilica of Saints Peter and Paul is located at 1723 Race Street in Philadelphia.
The beautiful interior of Christ Church, Philadelphia's most historic church.
While the Cathedral Basilica is the most beautiful church in Philadelphia, Christ Church is easily the most historic.
Christ Church was completed in 1744, with the steeple being added in 1754. From the steeple's completion until 1810, Christ Church was the tallest building in the country. During the Continental Conventions, Christ Church was the most popular church among the delegates, and many of our Founding Fathers worshipped regularly in the church. In addition, fifteen signers of the Declaration of Independence were members, including Benjamin Franklin.
The historic Christ Church in Philadelphia as seen from Market Street.
While the church was altered in the 1800s, it still retains much of its original appearance, including a pew that was used by George Washington during his presidency. This church was also the first church of the Episcopal church, which broke away from the Church of England after the Revolutionary War.
For more information on Christ Church, check out my full article about the church and its famous graveyard.
Christ Church is located at 20 North American Street in Philadelphia.
Gloria Dei Church
The beautifully restored interior of Pennsylvania's old church.
While Christ Church might be the most historically important church in Philadelphia, it's not the oldest church in the city. That honor goes to Gloria Dei Church (also known as Old Swedes').
The church was built between 1698 and 1700 and held its first service on July 2, 1700. That makes Gloria Dei the oldest church in all of Pennsylvania and the oldest surviving building in the historic boundaries of Philadelphia. The Swedish congregation dates back even further to 1677, five years before the formation of Philadelphia.
The exterior of Gloria Dei Church in South Philly.
The church has gone through renovations in the last few years to bring it back as closely as possible to its original appearance. Visitors can also walk through the church's graveyard, which has burials dating from the church's founding to modern times.
While it's a bit off the radar of many tourists, visiting this amazing piece of history is well worth the effort. You can find out more information about Gloria Dei Church on their website.
Gloria Dei Church is located at 916 S Swanson Street.
Old Pine Street Church
The unique facade of Old Pine Street Presbyterian Church.
The only Presbyterian church in Philadelphia that dates back to the Revolutionary War, Old Pine Street Church was founded in 1768. During the American Revolution, its pastor served as a chaplain for the First Continental Congress in 1774.
The church had many famous attendees, most notably John Adams and Jared Ingersoll, a signer of the US Constitution, though many Founding Fathers passed through the church at various times. This history earned Old Pine Street Church the nickname, "Church of the Patriots," and was one of the reasons the British used it as a hospital during their occupation of the city.
The cemetery surrounding Old Pine Street Presbyterian Church was used as a filming location for the movie "National Treasure."
The cemetery adjacent to the church is quite beautiful and was used as a filming location for the 2005 Disney movie, "National Treasure."
More information on the church and cemetery can be found on the Old Pine Street Church's website. The Church is located at 412 Pine Street in Philadelphia.
Old St. Joseph's National Shrine
The beautiful interior of Old St. Joseph National Shrine.
Old St. Joseph's might be the most hidden church in all of Philadelphia. Tucked away through a narrow passageway along a rarely visited alley, you could walk within feet of the church without ever knowing it was there.
Rumor has it that this secret location was at the encouragement of Benjamin Franklin, who encouraged Father Greaton to hide this church, the first urban Catholic church in the Americas, because of religious discrimination against Catholics. The first church here was built in 1733, and it was rebuilt in 1838.
Despite the outside looking more like a historic apartment block instead of a church, the inside is quite beautiful. What I liked about St. Joseph's was how it mixed colonial American style with the more ornate style you typically see in a Catholic church. This made for a really unique interior that seemed like someone had combined Christ Church with the Cathedral Basilica.
Behind this unremarkable entrance is the beautiful Old St. Joseph's.
This church was visited by the Marquis de Lafayette during his time in America and was the location of a high mass attended by both the American and French armies after the victory at Yorktown.
For more information on visiting the church, head over to its website. Old St. Joseph's National Shrine is located at 321 Willings Alley in Philly.
Mother Bethel American Methodist Episcopal Church
Mother Bethel American Methodist Episcopal Church is the oldest continually owned African American property in America (Photo Credit: Photo by R. Kennedy for Visit Philadelphia®)
One of the first African-American churches in the country, Mother Bethel was founded in 1794 by Richard Allen. Allen was born in 1760 as a slave owned by Benjamin Chew (who served as both the Attorney General of PA and the Chief Justice of Pennsylvania's Supreme Court). When Allen was 20 years old, he was able to buy his freedom.
Allen began to preach in Philadelphia, but drew such a following that he became unwelcome at white churches. So, in 1791, Allen bought property at the corner of 6th Street and Lombard Street with the help of several financial backers, including President George Washington. Three years later, in 1794, Allen first held services on the site. Then, in 1816, Allen started what we know today as the American Methodist Episcopal Church or AME Church.
The exterior of Mother Bethel AME Church as seen from across 6th Street.
The building that currently sits on the site is the fourth building built and was dedicated in 1890. The property has been owned by African Americans continuously since 1791, making it the oldest piece of land continuously owned by African Americans in the United States
The church is not open for self-guided visits as the other churches on this list are, but they offer tours six days a week. See their website for more information.
Mother Bethel American Methodist Episcopal Church is located at 419 South 6th Street in Philadelphia.
St. Peter's Episcopal Church
The beautiful pulpit at St. Peter's Episcopal Church in Philadelphia.
St. Peter's Episcopal Church was founded as an offshoot of Christ Church in 1758 on land donated by William Penn's sons, and worship services began in 1761. The Penn family crest can still be seen above the pulpit in the church.
The interior of the church looks much as it did in the 18th century, when many Founding Fathers worshipped here regularly. While they primarily went to Christ Church, George and Martha Washington worshipped at St. Peter's on many occasions.
The graveyard and exterior of St. Peter's Episcopal Church.
The church has a large cemetery surrounding it, which is the final resting place of Vice President George Dallas, Benjamin Chew, and several lesser-known Founding Fathers.
More information about the church can be found on their website. St. Peter's Episcopal Church is located at 313 Pine Street in Philadelphia.
Looking for other historic places to visit in the Philly area? Check out Bryn Athyn Cathedral, the Glencairn Museum, and the Caleb Pusey House.
See map below for other area attractions.
Visiting Bucks County's Other Ringing Rocks: Stony Garden in State Game Lands 157
Learning History and Smashing Misconceptions by Visiting Washington Crossing Historic Park
Discovering My Inner Child While Visiting the Philadelphia Zoo
Smith Memorial Playground: One of the Best Playgrounds in Philadelphia

redpajama_set_name: RedPajamaCommonCrawl


text:
Home>>World >> Americas
Fidel Castro says Cuban model doesn't work
In a talk with an American journalist, Cuban's Fidel Castro said that the country's economic model didn't work, The Associated Press reported Wednesday.
The fact that things are not working efficiently on the cash-strapped Caribbean island country is hardly news, The AP report said. Fidel's brother Raul Castro, the country's president, has said the same thing repeatedly. But the blunt assessment by the father of Cuba's 1959 revolution is sure to raise eyebrows, the report said.
Jeffrey Goldberg, a national correspondent for The Atlantic magazine, asked if Cuba's economic system was still worth exporting to other countries, and Mr. Castro replied: "The Cuban model doesn't even work for us anymore," Goldberg wrote Wednesday in a post on his Atlantic blog.
He said Castro made the comment casually over lunch following a long talk about the Middle East, and did not elaborate. Julia Sweig, a Cuba expert at the Washington-based Council on Foreign Relations who accompanied Goldberg on the trip, confirmed Castro's comment.
Sweig told The Associated Press she took the remark to be in line with Raul Castro's recent calls for gradual but widespread reform.
Since stepping down from power in 2006, Fidel Castro has focused almost entirely on international affairs and said very little about Cuba and its politics, perhaps to limit the perception he is stepping on his brother's toes, the AP report said.
Goldberg, who traveled to Cuba at Castro's invitation last week to discuss a recent Atlantic article he wrote about Iran's nuclear program, also reported Tuesday that Castro questioned his own actions during the 1962 Cuban Missile Crisis, including his recommendation to Soviet leaders that they use nuclear weapons against the United States.
Even after the fall of the Soviet Union in 1991, Cuba has clung to its political and economic system.
The state controls well over 90 percent of the economy, paying workers salaries of about $20 a month in return for free health care and education, and nearly free transportation and housing. At least a portion of every citizen's food needs are sold to them through ration books at heavily subsidized prices.
President Raul Castro and others have instituted a series of limited economic reforms, and have warned Cubans that they need to start working harder and expecting less from the government. But the president has also made it clear he has no desire to depart from Cuba's socialist system or embrace capitalism.
Fidel Castro stepped down temporarily in July 2006 due to a serious illness.
By People's Daily Online
(Editor:张心意)
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U.S. in "checkmate," says Fidel Castro
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Custom designed invitations and stationery are our passion. We just love hearing the details of your event, and brainstorming creative ways to add a unique touch to each invitation and stationery set we work on.
Below you'll find a selection of some of our favorite invitation designs we've created over the years. Want to see more? Check out some work from the designers we carry as well, make an appointment to come in, or fill our our personal shopper survey and we'll send some images of designs we think you'll love!


This safety video gets it absolutely right. It's charming, amusing, fun, but not comic, which has always seemed wrong to me (Air New Zealand – I'm talking about you).
The video manages to represent the diversity of Australia in terms of people, place, landscape, and terrain. it's relaxed, not too serious, not too laid back, but very Australian. Its full of light, and lightness.
Well done Qantas and your communications agency. This hits it on the nail for both your fellow Australians and for the way we are and would like to be perceived around the world. It a great thing for travellers to see when they get on an A380 to come down and see us.
I'm not always a fan of Qantas, but this time they have it dead right.
PreviousWanna go to Rio, De Janiero?


Digital label printing combines design flexibility with significant production cost savings. The use of digital software not only eliminates the time and costs associated with the production of printing plates but also allows changes to be made to the label design at little or no additional cost. This is ideal for prototypes or small runs, as it enables customers to adjust their labeling as needed as their products evolve. It is also ideal for promotional labels for holidays or special events, as clients can produce labeling in virtually any volume without the initial investment required by conventional printing.
Customers can save when ordering multiple versions of the same label size and material by taking advantage of our "Versions" option.
into one unit, giving you a price break based on the total quantity. You read that right!
You can print entirely different artwork on each "lot" and combine those versions into one order, to get a much lower price.
In order to qualify, versions must be printed on the same material with the same options (size, shape, laminate/varnish).
With digital label printing, customers have the highest level of control over the labels they produce, saving both their budget and resources. Additionally, by increasing the economic viability of short and medium print runs, digital printing produces less overall waste, which helps clients to supplement their cost savings with a more sustainable printing process.
In fact, digital label printing allows us to consider the environment during every step of the production cycle. Digital presses can print on environmentally certified media, such as 100% recycled substrate, and are compatible with environmentally safe adhesives, primers, and biodegradable substrates.
While small print runs rely heavily on digital label printing, our broader digital capabilities are growing all the time. We have multiple HP Indigo digital presses, which provide our customers with a fast turnaround and ensure that Star Label Products will deliver your labels on time!
Both digital presses are capable of print runs that are faster than ever before. Longer production runs that were once taken on almost exclusively by conventional printing methods can now be handled solely through digital processes. This has allowed for expanded savings and flexibility for all varieties of customers — from food and beverage or pharmaceutical clients to cosmetics or appliance manufacturers.
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Flat Bed Embossing — Provides raised areas on labels that attract the eye and touch of potential customers.


Student activist Nathan Law Kwun-chung, 23, has been elected as Hong Kong's youngest-ever legislator, winning 50,818 votes in Sunday's polls to win one of six seats in the Hong Kong Island geographical constituency of the Legislative Council.
Law, a co-founder of the group Demosisto, trailed only top vote-getter Regina Ip of the New People's Party, who amassed 60,760 votes.
But even though most pre-election polls pointed to a relatively easy win for media tycoon Ricky Wong who ran as an independent, he was left on the outside looking in – falling around 2,000 votes short.
Law said he feels both happy and nervous, as he was entering "a new stage of his life" which is going to be a great challenge. He said voters showed that they trusted that he can propel the democratic movement in a new direction. Law – whose group has called for a referendum in ten years' time to determine Hong Kong's future – promised to initiate discussions on the topic in the council.
The remaining four seats went to candidates who picked up the torch from their colleagues. The Horace Cheung from the Democratic Alliance for the Betterment and Progress of Hong Kong and the Federation of Trade Union's Kwok Wai-keung won on the pro-government side, replacing Christopher Chung and Wong Kwok-hing.
For the pan-democrats, newcomer Ted Hui from the Democratic Party won a seat to take over from retiring incumbent Sin Chung-Kai, while the Civic Party's Tanya Chan returned to the council as a legislator after a four-year absence to take over from Kenneth Chan.
Hui said the result was "a bit better than expected", and he will be able to relax a bit now that the campaigning was over.


text:
S-Methylation of D- and L-penicillamine by human erythrocyte membrane thiol methyltransferase
R. A. Keith, D. M. Otterness, A. L. Kerremans, R. M. Weinshilboum
Human red blood cell (RBC) membranes contain a thiol methyltransferase activity that catalyzes the S-methylation of 2-mercaptoethanol (2-ME). These experiments were performed to determine whether human RBC membranes contain enzymes that can catalyze the S-methylation of D- and L-penicillamine, to determine whether those enzymes are similar to the RBC membrane thiol methyltransferase that catalyzes the S-methylation of 2-ME, and to determine whether lipophilic conjugates of the S-methyl metabolites of D- and L-penicillamine are formed by RBC membranes. Human RBC membranes were able to catalyze the S-methylation of D- and L-penicillamine. The apparent Michaelis (K(m)) constants for D- and L-penicillamine were 7.53 and 7.27 mM, respectively. However, the V(max) value for L-penicillamine was more than 2.5 times greater than the V(max) value for D-penicillamine D- and L-penicillamine methyltransferases and 2-ME thiol methyltransferase were with respect to their subcellular distributions, inhibitor sensitivities, and thermal stabilities. In addition, when methyltransferase activities for 2-ME and for D- and L-penicillamine were measured in RBC membranes from 19 individual subjects, there were highly significant correlations among all three activities (r > 0.98, p < 0.001 for all three comparisons). These observations suggest either that a single enzyme in the human RBC membrane catalyzes the S-methylation of all three compounds, or, less likely, that these reactions are catalyzed by three separate enzymes that are regulated in parallel and have similar properties. Experiments were then performed to identify the products of the penicillamine methylation reactions. It was found that alkaline hydrolyzable lipophilic conjugates of the S-methyl derivatives of D- and L-penicillamine were formed during in vitro incubation with RBC membrane preparations. It remains to be determined whether lipophilic conjugates of the S-methyl metabolites of D-penicillamine and of other carboxylic acid sulfhydryl drugs are formed in vivo.
Drug Metabolism and Disposition
Dive into the research topics of 'S-Methylation of D- and L-penicillamine by human erythrocyte membrane thiol methyltransferase'. Together they form a unique fingerprint.
thiol S-methyltransferase Medicine & Life Sciences 100%
L-Penicillamine Chemical Compounds 84%
Penicillamine Medicine & Life Sciences 62%
Methylation Medicine & Life Sciences 44%
Thiol Chemical Compounds 41%
Red Chemical Compounds 29%
Erythrocytes Medicine & Life Sciences 27%
Keith, R. A., Otterness, D. M., Kerremans, A. L., & Weinshilboum, R. M. (1985). S-Methylation of D- and L-penicillamine by human erythrocyte membrane thiol methyltransferase. Drug Metabolism and Disposition, 13(6), 669-676.
S-Methylation of D- and L-penicillamine by human erythrocyte membrane thiol methyltransferase. / Keith, R. A.; Otterness, D. M.; Kerremans, A. L. et al.
In: Drug Metabolism and Disposition, Vol. 13, No. 6, 1985, p. 669-676.
Keith, RA, Otterness, DM, Kerremans, AL & Weinshilboum, RM 1985, 'S-Methylation of D- and L-penicillamine by human erythrocyte membrane thiol methyltransferase', Drug Metabolism and Disposition, vol. 13, no. 6, pp. 669-676.
Keith RA, Otterness DM, Kerremans AL, Weinshilboum RM. S-Methylation of D- and L-penicillamine by human erythrocyte membrane thiol methyltransferase. Drug Metabolism and Disposition. 1985;13(6):669-676.
Keith, R. A. ; Otterness, D. M. ; Kerremans, A. L. et al. / S-Methylation of D- and L-penicillamine by human erythrocyte membrane thiol methyltransferase. In: Drug Metabolism and Disposition. 1985 ; Vol. 13, No. 6. pp. 669-676.
@article{7214f56aadd14a56b4b94448663e363f,
title = "S-Methylation of D- and L-penicillamine by human erythrocyte membrane thiol methyltransferase",
abstract = "Human red blood cell (RBC) membranes contain a thiol methyltransferase activity that catalyzes the S-methylation of 2-mercaptoethanol (2-ME). These experiments were performed to determine whether human RBC membranes contain enzymes that can catalyze the S-methylation of D- and L-penicillamine, to determine whether those enzymes are similar to the RBC membrane thiol methyltransferase that catalyzes the S-methylation of 2-ME, and to determine whether lipophilic conjugates of the S-methyl metabolites of D- and L-penicillamine are formed by RBC membranes. Human RBC membranes were able to catalyze the S-methylation of D- and L-penicillamine. The apparent Michaelis (K(m)) constants for D- and L-penicillamine were 7.53 and 7.27 mM, respectively. However, the V(max) value for L-penicillamine was more than 2.5 times greater than the V(max) value for D-penicillamine D- and L-penicillamine methyltransferases and 2-ME thiol methyltransferase were with respect to their subcellular distributions, inhibitor sensitivities, and thermal stabilities. In addition, when methyltransferase activities for 2-ME and for D- and L-penicillamine were measured in RBC membranes from 19 individual subjects, there were highly significant correlations among all three activities (r > 0.98, p < 0.001 for all three comparisons). These observations suggest either that a single enzyme in the human RBC membrane catalyzes the S-methylation of all three compounds, or, less likely, that these reactions are catalyzed by three separate enzymes that are regulated in parallel and have similar properties. Experiments were then performed to identify the products of the penicillamine methylation reactions. It was found that alkaline hydrolyzable lipophilic conjugates of the S-methyl derivatives of D- and L-penicillamine were formed during in vitro incubation with RBC membrane preparations. It remains to be determined whether lipophilic conjugates of the S-methyl metabolites of D-penicillamine and of other carboxylic acid sulfhydryl drugs are formed in vivo.",
author = "Keith, {R. A.} and Otterness, {D. M.} and Kerremans, {A. L.} and Weinshilboum, {R. M.}",
journal = "Drug Metabolism and Disposition",
publisher = "American Society for Pharmacology and Experimental Therapeutics",
T1 - S-Methylation of D- and L-penicillamine by human erythrocyte membrane thiol methyltransferase
AU - Keith, R. A.
AU - Otterness, D. M.
AU - Kerremans, A. L.
AU - Weinshilboum, R. M.
N2 - Human red blood cell (RBC) membranes contain a thiol methyltransferase activity that catalyzes the S-methylation of 2-mercaptoethanol (2-ME). These experiments were performed to determine whether human RBC membranes contain enzymes that can catalyze the S-methylation of D- and L-penicillamine, to determine whether those enzymes are similar to the RBC membrane thiol methyltransferase that catalyzes the S-methylation of 2-ME, and to determine whether lipophilic conjugates of the S-methyl metabolites of D- and L-penicillamine are formed by RBC membranes. Human RBC membranes were able to catalyze the S-methylation of D- and L-penicillamine. The apparent Michaelis (K(m)) constants for D- and L-penicillamine were 7.53 and 7.27 mM, respectively. However, the V(max) value for L-penicillamine was more than 2.5 times greater than the V(max) value for D-penicillamine D- and L-penicillamine methyltransferases and 2-ME thiol methyltransferase were with respect to their subcellular distributions, inhibitor sensitivities, and thermal stabilities. In addition, when methyltransferase activities for 2-ME and for D- and L-penicillamine were measured in RBC membranes from 19 individual subjects, there were highly significant correlations among all three activities (r > 0.98, p < 0.001 for all three comparisons). These observations suggest either that a single enzyme in the human RBC membrane catalyzes the S-methylation of all three compounds, or, less likely, that these reactions are catalyzed by three separate enzymes that are regulated in parallel and have similar properties. Experiments were then performed to identify the products of the penicillamine methylation reactions. It was found that alkaline hydrolyzable lipophilic conjugates of the S-methyl derivatives of D- and L-penicillamine were formed during in vitro incubation with RBC membrane preparations. It remains to be determined whether lipophilic conjugates of the S-methyl metabolites of D-penicillamine and of other carboxylic acid sulfhydryl drugs are formed in vivo.
AB - Human red blood cell (RBC) membranes contain a thiol methyltransferase activity that catalyzes the S-methylation of 2-mercaptoethanol (2-ME). These experiments were performed to determine whether human RBC membranes contain enzymes that can catalyze the S-methylation of D- and L-penicillamine, to determine whether those enzymes are similar to the RBC membrane thiol methyltransferase that catalyzes the S-methylation of 2-ME, and to determine whether lipophilic conjugates of the S-methyl metabolites of D- and L-penicillamine are formed by RBC membranes. Human RBC membranes were able to catalyze the S-methylation of D- and L-penicillamine. The apparent Michaelis (K(m)) constants for D- and L-penicillamine were 7.53 and 7.27 mM, respectively. However, the V(max) value for L-penicillamine was more than 2.5 times greater than the V(max) value for D-penicillamine D- and L-penicillamine methyltransferases and 2-ME thiol methyltransferase were with respect to their subcellular distributions, inhibitor sensitivities, and thermal stabilities. In addition, when methyltransferase activities for 2-ME and for D- and L-penicillamine were measured in RBC membranes from 19 individual subjects, there were highly significant correlations among all three activities (r > 0.98, p < 0.001 for all three comparisons). These observations suggest either that a single enzyme in the human RBC membrane catalyzes the S-methylation of all three compounds, or, less likely, that these reactions are catalyzed by three separate enzymes that are regulated in parallel and have similar properties. Experiments were then performed to identify the products of the penicillamine methylation reactions. It was found that alkaline hydrolyzable lipophilic conjugates of the S-methyl derivatives of D- and L-penicillamine were formed during in vitro incubation with RBC membrane preparations. It remains to be determined whether lipophilic conjugates of the S-methyl metabolites of D-penicillamine and of other carboxylic acid sulfhydryl drugs are formed in vivo.
JO - Drug Metabolism and Disposition
JF - Drug Metabolism and Disposition


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text:
Q: How can I create two files of identical size and date modified? We are using some backup tooling that copies files from source to destination. Part of this is MD5 checking the files to see if the contents have changed.
How can I create two identical sized and date created files on my machine with different contents? Is there a script or online service I can use? I'd like to use these for a test scenario e.g.

*

*files same size different timestamp = sync files to backup

*files same size different content same timestamp = sync files to backup

Bash or Python is okay script wise. We are looking to use rsync --checksum in combination with aws s3 sync at the moment but need to test specific scenarios to be sure these tools do what we want.
Thanks

A: You can create a file with a specified size and arbitrary content using head --bytes=NUM < /dev/urandom >newfile, where NUM is the filesize in bytes and also accepts a multiplier suffix such as MB or GB (check the manual of head). You can run this command twice to make two files of the same size and different content, or just run it once and then copy the file to get files with the same size and content.
Timestamps can be manipulated with touch --date=STRING. Either touch both using the same date string, or touch them with different date strings to give them different timestamps.

redpajama_set_name: RedPajamaStackExchange


text:
Q: wp7 XNA app - Microsoft ad not coming in downloaded app I am facing very strange issue currently. I have windows phone 7 application, built using XNA framework. I have put microsoft ad control for same.
The issue is, the .XAP file which I submitted to Marketplace; if i deploy that file to my phone, microsoft ads are coming fine.
BUT, when i download the app from marketplace via wi-fi, after the app starts, the ads are not coming.
I verified all and this is really strange. I am clueless and can anyone please tell if has faced such issue?
Thanks,
David

A: Do you see the advertising control on your page? Does it just appear as a black box without ads? I have never used the adevertising SDK with an XNA app before but I know they take a few seconds to appear in my XAML-based apps.
I am including this MSDN link to a sample app that uses XNA and the advertising SDK. Hopefully this will help you out.


text:
Q: Relative path problem in ANT junit task I have setup an ant script as eclipse builder to automatically run all my tests, like below:
<project name="auto-test" default="test">
    <property name="tst-dir" location="C:\STAF\services\custom\TopCoder\bin" />
    <path id="classpath.base" />
    <path id="classpath.test">
        <pathelement location="D:\eclipse\eclipse\plugins\org.junit4_4.3.1\junit.jar" />
        <pathelement location="${tst-dir}" />
        <path refid="classpath.base" />

    </path>
    <target name="test" description="Run the tests">
        <junit>
            <classpath refid="classpath.test" />
            <formatter type="brief" usefile="false" />
            <test name="testDataGenerator.test.AllTests" />
        </junit>
    </target>
</project>

It was all good before I changed a test fixture file from absolute path to relative path:
SAXReader reader = new SAXReader();
Document document = reader.read(new File(".").getCanonicalPath()+"\\conf\\TestData.xml");

The ant task now try to open D:\eclipse\eclipse\conf\TestData.xml, instead of C:\STAF\services\custom\TopCoder\conf\TestData.xml, I've also try to run AllTests manually from Eclipse and it's all good.
Has anyone met similar problem before?
Thanks in advance.
PS. ANT_HOME=D:\eclipse\eclipse\plugins\org.apache.ant_1.7.0.v200706080842
Follow up:
I tried to run the ant script from command line, and find below:

*

*C:\STAF\services\custom\TopCoder>ant -f c:\STAF\services\custom\TopCoder\task\build.xml, the ant script works correctly.

*C:>ant -f c:\STAF\services\custom\TopCoder\task\build.xml, the script will claim: [junit] C:\conf\TestData.xml (The system cannot find the path specified)
I've also checked eclipse builder setting, there seems nothing to change the path to D:\eclipse\eclipse.

A: Java resolves relative paths against the current user directory, which is typically the directory from where the java program was invoked.
One way to overcome this issue is to define an environmental variable for your base path. Then, you could easily use "relative paths" (meaning, create absolute paths by concatenating the base path and the relative path).

A: Here is the solution I find:
Just as kgiannakakis mentioned, Ant also start executing its task from the location it was invoked, so we just need to change the working directory setting of our custom eclipse builder.

*

*In the JRE tab, choose "Execution Environment".

*Change the Working directory to your current workspace.

A: Looks like I've missed the karma but anyway...
We do this:-
Build.xml
<project name="whatever">
  <property file="build.${env.COMPUTERNAME}.properties"/>
  <property file="build.properties"/>

build.properties
project.root=..
build.file.dir=${project.root}/buildfiles
deploy.dir=${project.root}/deploy

which of course you can override by creating your OWN build.computername.properties to allow for developer path differences etc


lay the fabric, right side up, on top of the inside hoop and then put the top hoop over the inside one….pulling tight the fabric.
you will want about a half inch or so of fabric to hang out so you can glue it down….and then trim and then done! now just throw a nail in the wall and yay!
you can get creative and paint on the fabric or even do some stitching. i wanted to keep it simple and enjoy the fabric. i love the new additions. the mister hasn't called it too girly yet so we're doing good!
notes: embroidery hoops/hobby lobby, fabric/vintage, coat hanger/urban outfitters, chalkboard/event design shop, mirror/thrifted.
AHH I LOVE IT!!! When I was preggo (and hence obsessively researching nursery ideas), the one I loved most had these embroidery hoops with fabric in them covering most of an entire wall. Of course, then I realized that we wouldn't actually have a nursery, being as it's NYC and anything over a 1-bedroom is ridiculously expensive, but still. Love.


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Fast & Fresh Pizza Delivery Near Sistersville - Order Domino's Now!
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At Domino's near Sistersville, it's never been easier to get the fast and fresh pizza your tastebuds are begging you for! Order your pizza online or over the phone, or stop by and place a carryout order at the Domino's nearest you.
Get started by selecting your favorite crust. Choose from a hand-tossed crust that's overflowing with buttery flavor, a crispy thin crust, a pan crust featuring two delicious layers of cheese, or even a gluten-free pizza crust! Next, pick your sauce and start piling on your favorite toppings. Don't be shy! Choose as many as you want. Whether you want to combine sausage, bacon, salami and green peppers, or stick to a blend of cheddar, mozzarella, feta, and asiago cheese, your nearest Domino's location has it all.
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When it comes to pizza delivery, we take things pretty seriously at your local Domino's near Sistersville. In fact, we promise your pizza will arrive hot and fresh at your door, right out of our oven. Want to know what's happening with your order like, right now? Use our expertly engineered Domino's TrackerⓇ to follow along as your order is prepped, baked, checked for quality, and sent out our door for delivery... and in the meantime, try not to drool on your phone or computer.
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The Community Health Needs Assessment Report details the process used to collect, disseminate and prioritize the information in the assessment. The Medical Center at Scottsville worked closely with local healthcare and public health leaders throughout the assessment process.
Through this health planning The Medical Center at Scottsville is able to determine our patient's health needs and begin to address some of these needs during treatment and after discharge. Some specific areas of concern to this area are the lack of mammography screenings, the county average is well below the state average, occurrence of lung cancer in this area, Cardiovascular Disease, Obesity, and Motor Vehicle Crash Deaths. Through proper planning and community outreach The Medical Center at Scottsville should be able to make improvements in awareness of these health issues.


text:
Q: Undo-tree style git in terminal There's a package for Emacs which lets you use an undo-tree instead of just going forward and backwards with undo: http://www.emacswiki.org/emacs/UndoTree
Is there a similar thing for git, which would let you look at a tree of commits and select one? Either on the command line or in Emacs?

Note: I'm new to Emacs, and I've installed the excellent Emacs Live - https://github.com/overtone/emacs-live - which seems to include magit. Emacs Live has a system to add customizations - the files go in ~/.live-packs/cannyboy-pack/ . Within that is an init.el file which references files within another folder - config. So I added (live-load-config-file "magit-custom.el") and added a magit-custom.el file in config with @event_jr's code, and then referenced that in ~/.live-packs/cannyboy-pack/init.el by adding (live-load-config-file "magit-custom.el")

A: In Emacs, you can see a file's git commit log tree with magit's magit-file-log
command, and open up the log's diff by pressing RETURN.  We can
build on top of magit and Emacs's internal version control aware features to
visit the file directly.

*

*Download install magit.

*Add to your "init.el"
(defun my-magit-visit-file-at-commit (&optional other-window)
  "Visit current commit's file in another window.

This command makes sense from a `magit-file-log' buffer. "
  (interactive "P")
  (magit-section-action (item info "visit")
    ((commit)
     (let ((filename (expand-file-name (car magit-refresh-args)
                                       (concat (magit-git-dir) "../"))))
       (if (file-readable-p filename)
           (progn
             (find-file-noselect filename)
             (with-current-buffer (find-buffer-visiting filename)
               (vc-revision-other-window info)))
         (message "not able to access %s" filename))))))

(eval-after-load "magit.el"
  '(define-key magit-log-mode-map (kbd "C-c o") 'my-magit-visit-file-at-commit))

*restart Emacs

*open the file whose commit history you're interested in.

*M-x magit-file-log

*go to interesting commit press C-c o
edit fix missing keymap specification.

A: I think that magit is what you are looking for.
Here is a good tutorial showing it's use.
You should also have a look at Egg, which is said to have a better user interface.