text:
Strong relationship between cholesterol, low-density lipoprotein receptor, Na+/H+ exchanger, and SARS-COV-2: this association may be the cause of death in the patient with COVID-19
Erkan Cure1 &
Medine Cumhur Cure2
Lipids have a wide variety and vital functions. Lipids play roles in energy metabolism, intracellular and extracellular signal traffic, and transport of fat-soluble vitamins. Also, they form the structure of the cell membrane. SARS-CoV-2 interacts with lipids since its genetic material contains lipid-enveloped ribonucleic acid (RNA). Previous studies have shown that total cholesterol, high-density lipoprotein, and low-density lipoprotein (LDL) levels are lower in patients with severe novel coronavirus disease 2019 (COVID-19) compared to patients with non-severe COVID-19.
Na+/H+ Exchanger (NHE) is an important antiport that keeps the intracellular pH value within physiological limits. When the intracellular pH falls, NHE is activated and pumps H+ ions outward. However, prolonged NHE activation causes cell damage and atherosclerosis. Prolonged NHE activation may increase susceptibility to SARS-CoV-2 infection and severity of COVID-19.
In COVID-19, increased angiotensin II (Ang II) due to angiotensin-converting enzyme-2 (ACE2) dysfunction stimulates NHE. Lipids are in close association with the NHE pump. Prolonged NHE activity increases the influx of H+ ions and free fatty acid (FFA) inward. Ang II also causes increased low-density lipoprotein receptor (LDLR) levels by inhibiting proprotein convertase subtilisin/kexin type 9 (PCSK9). Thus, intracellular atheroma plaque formation is accelerated.
Besides, SARS-CoV-2 may replicate more rapidly as intracellular cholesterol increases. SARS-CoV-2 swiftly infects the cell whose intracellular pH decreases with NHE activation and FFA movement. Novel treatment regimens based on NHE and lipids should be explored for the treatment of COVID-19.
Lipids have a wide variety and crucial functions. Lipids play roles in energy metabolism, intracellular and extracellular signal traffic, and transport of fat-soluble vitamins. Also, they form the structure of the cell membrane [1]. Lipids are used as building blocks and energy sources in the membranes of viral organelles formation, so lipids are vital during viral infection [1]. The regulation of macrophages and many immunomodulatory pathways are associated with lipids, and lipids are involved in pulmonary infection diseases and inflammatory conditions [2]. Ribonucleic acid (RNA) viruses require some particles for viral entry into host cells and to escape the host immune system. Lipids are needed for intercellular and intracellular signaling during the production of particles required for RNA viruses [2]. SARS-CoV-2 interacts with lipids since its genetic material contains lipid-enveloped RNA [3]. Previous studies have shown that total cholesterol, high-density lipoprotein, and low-density lipoprotein (LDL) levels are lower in patients with severe novel coronavirus disease 2019 (COVID-19) compared to patients with non-severe COVID-19 [4].
Na+/H+ exchanger (NHE) is a crucial antiport that keeps the intracellular pH value within certain limits. NHE pumps H+ ions outward when the intracellular pH drops. Recently, it has been suggested that NHE may increase susceptibility to SARS-CoV-2 and the severity of COVID-19 [5, 6]. Interestingly, there is also an interaction between lipids and NHE [7]. Here, we examined whether there is a triple interaction between SARS-CoV-2, lipids, and NHE.
SARS-CoV-2 and cholesterol
Cholesterols act as a conductor during the entry of SARS-CoV-2 into the cell by fusing with angiotensin-converting enzyme-2 (ACE2); therefore, high cholesterol levels may increase susceptibility to SARS-CoV-2 [8]. According to this theory, lowering cholesterol with statin therapy can reduce viral replication. On the other hand, cholesterol plays a vital role in the gathering, replication, and infectivity of the viral RNA of SARS-CoV-2 [9]. A previous study reported that cholesterol metabolism-related proteins such as LDL, LDL receptor (LDLR)-related protein (LRP), Apo B, Apo E were diminished in SARS-CoV-2 infected human colon epithelial carcinoma cells [10]. In most studies investigating lipid levels in patients with COVID-19, it has been shown that low lipid levels increase mortality and disease severity in COVID-19 [11]. The virus can interact intensively with cholesterol, causing it to shift into the cell, and it may use cholesterol, lowering its level.
On the other hand, LDL carries a large percentage of plasma Coenzyme Q10 (CoQ10), which has a significant antioxidant capacity and prevents peroxidative damage to cellular membranes [12]. Low LDL levels may contribute to endothelial dysfunction by causing a decrease in plasma CoQ10 levels. As a result, low serum cholesterol levels may increase the severity and damage of COVID-19.
Lipid raft and SARS-CoV-2
Lipid rafts are dynamic regions in the cell membrane ranging from 10 to 200 nm. They contain sphingolipids, glycosphingolipids, cholesterol, and glycosylphosphatidylinositol-associated proteins [13]. Lipid rafts are involved in tasks like intercellular signal transduction, trafficking, endocytosis, and viral infection [14]. Cholesterol is an essential component of lipid rafts and interferes with various aspects of the virus life cycle, particularly viral entry [15, 16]. Coronavirus and other many enveloped viruses enter cells through cholesterol in viral and cellular membranes [17]. SARS-CoV-2 associates with ACE2 in lipid rafts and starts a signaling cascade that allows virus endocytosis [2, 14]. That is, SARS-CoV-2 enters the cell using lipid rafts.
Statins, Proprotein convertase Subtilisin/Kexin type 9 (PCSK9) inhibitors and COVID-19
Statins have anti-inflammatory, antioxidant, and anti-thrombotic effects [18]. They also lead to ACE2 upregulation in heart and kidney tissue [18]. By lowering cholesterol, statins and PCSK9 inhibitors can block entry of SARS-CoV-2 into the host cell or inhibit its replication [19]. If low cholesterol levels are associated with COVID-19 mortality, then is lowering cholesterol levels the eligible treatment? Detailed studies are needed on this subject.
On the other hand, statins may exert a direct antiviral effect by interacting with the main protease enzyme of SARS-CoV-2 [20]. PCSK9 inhibitors may exert potent antiviral effects against SARS-CoV-2 by increasing type I interferon levels [21].
SARS-CoV-2 and LDLR
LDLR is the structure within the cell containing the type I transmembrane protein family that removes cholesterol-carrying lipoproteins from the plasma circulation [22]. Viruses that settle inside the cell enter the cell through cholesterol, interact with LDLR and cause infection [23]. LRP-1 is a protein belonging to the LDLR family. Human cytomegalovirus can easily fuse with the plasma membrane by increasing the expression of LRP-1 [24]. When the intracellular pH is acidic, the glycoprotein of the vesicular stomatitis virus interacts with the LDLR-domain, thus the virus causes the infection [25]. Some serotypes of human rhinoviruses also enter cells through this family of receptors [26]. Hepatitis C virus increases LDLR expression while suppressing PCSK9 expression. Thus, it effortlessly infects the cell [27]. Same way as the viruses mentioned above, SARS-CoV-2 can also interact with LDLR while using cholesterol for RNA replication. As a result of this interaction, intracellular cholesterol storage may increase. HMG-CoA reductase activity and cholesterol synthesis decrease when intracellular cholesterol storage increases [28]. Therefore, patients with COVID-19 may have low plasma cholesterol, which may be evidence that the virus affects LDLR.
SARS-CoV-2, angiotensin (Ang) II, and LDLR mediated plaque formation
SARS-CoV-2 causes infection by fusing with ACE2. ACE2 converts Ang II to Ang 1–7 and 9des-bradykinin to its metabolites [29]. Ang II causes vasoconstriction and increased oxidative stress, while Ang 1–7 has vasodilator and antioxidant effects [5]. When the virus fuses with ACE2, Ang II degradation stops, and its level increases [29]. Ang II is directly related to lipid metabolism as well as its oxidant effects. Ang II decreases PCSK9 expression in aortic smooth muscle cells and thus increases the number of LDLRs in the membrane [30]. When the number of LDLR increases, lipid accumulation occurs in the cell membrane and within the cell, and the lipid level in the blood decreases [31]. Although this effect seems beneficial, Sendra et al. described a mechanism by which Ang II causes cholesterol infiltration in the arteria intima by upregulating LRP1 [32]. Most COVID-19 patients with mortality have obesity, diabetes, hypertension, and atherosclerotic heart disease. These patients are already predisposed to atherosclerosis, and excessive Ang II levels during COVID-19 may upregulate LDLR, accelerating intimal plaque formation. Since the increase in Ang II also increases the tendency to thrombosis, patients with COVID-19 may die suddenly from a heart attack even though their blood cholesterol is low.
Additionally, acute phase response during COVID-19 may lead to oxide-LDL formation and LDLR upregulation [12]. Oxide-LDL via lectin-like oxidized LDLR-1 (LOX-1) activation leads to ACE gene expression [33]. Upregulation of ACE downregulates ACE2, vice versa [29]. Ang II level may be excessively elevated in patients with COVID-19 since ACE2, which has already fused with the virus, is also dysfunctional. Therefore, Ang II-LDLR-related endothelial dysfunction and arterial plaque formation may be excessively accelerated.
Relationship between lipids, NHE and COVID-19
When the intracellular pH drops, NHE is physiologically activated. NHE pumps 3Na+ ions into the cell and 2H+ out of the cell. NHE rapidly brings the intracellular pH to a physiological level, and its activity ceases [5]. There is a close relationship between NHE and lipids. Megalin is a member of the LDLR family, which is abundant in proximal tubular cells. Also, it is found in type II pneumocyte, brain, epididymis, eye, ear, and thyroid tissues [34]. The virus may infect all tissues containing megalin. Previous work has shown that megalin interacts with NHE3 through the NHE regulatory cofactor. In this way, there is a connection between NHE3 and megalin [34]. This interaction is also likely to occur in other tissues containing megalin. There is a strong interaction between Angiotensinogen, Ang II, and megalin. This interaction accelerates the atherosclerotic process [35]. Since Ang II is the potent activator of NHE, megalin also stimulates NHE indirectly.
Besides, lipid raft affects NHE1 and NHE3 activity [7, 36]. Intestinal NHE3 activity and Na+ absorption increased in the postprandial period [36]. A previous study showed that increased NHE activity in the liver tissue of rats increased the extracellular H+ ion flux. At the end of this event, the transmembrane movement of free fatty acids (FFA) increases and FFA and H+ ions pass into the cell [37]. The influx of H+ ions with the FFA into the cell lowers the intracellular pH and activates NHE again [37]. This process can become a vicious circle in the patient with COVID-19.
On the other hand, in tissues such as the pancreas and adipose tissue, the movement of FFA into the cell acidifies the intracellular pH [38, 39]. Insulin promotes the conversion of FFA to triglycerides and activates NHE [5, 39]. During this event, the intracellular pH increases due to the outflow of H+ ions from the intracellular space. Insulin deficiency or insulin resistance causes an increase in FFA flow into the cell and a decrease in intracellular pH [39]. Intracellular FFA efflux causes inhibition of glycolysis and glucose intolerance [38]. Ang II causes insulin resistance by increasing oxidative stress [40], and patients with COVID-19 have insulin resistance due to the increase in Ang II [41]. As a result of these events, intracellular FFA influx and prolonged NHE activation may accelerate the atherosclerotic process in patients with COVID-19.
SARS-CoV-2 main protease activity is easily affected by intracellular pH, and its infectivity increases at low pH values [42]. Therefore, increasing the intracellular pH has been one of the cornerstones of the treatment of COVID-19. Interestingly, in patients with obesity, diabetes, hypertension, and cardiac disease, the intracellular pH is acidic compared to normal individuals [5]. Ang II level is high in these patients, and there is a prolonged NHE stimulation. During prolonged NHE activation, H+ ions are pumped out of the cell. As a result of prolonged NHE pumping, reactive oxygen radicals increase outside the cell. With the redox reaction, H+ ions are returned to the cell. Thus, the intracellular pH becomes acidic [5]. The interaction between NHE and FFA contributes to intracellular pH reduction by an influx of FFA and H+ into the cell. SARS-CoV-2 can decrease intracellular pH by interacting with lipids and NHE either directly or indirectly by increasing Ang II. Thus, at acidic intracellular pH, the virus can easily invade the cell. On the other hand, extracellular H+ increase and intracellular lipid accumulation can cause accelerated atherosclerosis and sudden heart attack [43, 44].
Physiologically, PCSK9 activity increases as the intracellular pH becomes acidic [45]. PCSK9 binds to and breaks down LDLR in liver cells. LDLR, which cannot return to the cell surface, cannot enter the liver cells, and its level increases within the cell [46]. Interestingly, SARS-CoV-2 may suppress PCSK9 by increasing Ang II and increased LDLR levels. At acidic intracellular pH, LDL dissociates from LDLR. LDLR returns to the cell surface. LDL separated from its receptor is broken down into cholesterols in lysosomes. The released cholesterol is used by the cell [47]. SARS-CoV-2 may use the increased cholesterol within the cells for replication and signal transduction. Prolonged NHE activation and intracellular lipid accumulation can increase the replication of the virus and cause it to spread effortlessly.
Another paramount issue is that LDL reduces platelet functions by inhibiting NHE activation in platelets, thus exerting an antithrombotic effect [48]. However, this effect is only seen in native LDL at a physiological level. In SARS-CoV-2 infection, while native LDL decreases, the oxidized LDL levels increases [49]. In addition to other mechanisms, a decrease in LDL levels in patients with COVID-19 may also cause an increase in thrombotic events.
ACE2 blockade in COVID-19 increases Ang II, leading to prolonged NHE activity. The activity acidifies the intracellular pH with redox reactions. FFAs move into the cell with H+ ions. High cholesterol inside the cell can accelerate atherosclerosis and cause sudden cardiac death. Besides, SARS-CoV-2 may replicate more rapidly as intracellular cholesterol increases. SARS-CoV-2 straightforwardly infects the cell whose intracellular pH decreases with NHE activation and FFA movement. Novel treatment regimens based on NHE and lipids should be explored for the treatment of COVID-19.
Liu P, Bartz R, Zehmer JK, Ying YS, Zhu M, Serrero G, et al. Rab-regulated interaction of early endosomes with lipid droplets. Biochim Biophys Acta. 2007;1773(6):784–93. https://doi.org/10.1016/j.bbamcr.2007.02.004.
Rezaei A, Neshat S, Heshmat-Ghahdarijani K. Alterations of lipid profile in COVID-19: a narrative review. Curr Probl Cardiol. 2021;100907. https://doi.org/10.1016/j.cpcardiol.2021.100907.
Alsobaie S. Understanding the molecular biology of SARS-CoV-2 and the COVID-19 pandemic: a review. Infect Drug Resist. 2021;14:2259–68. https://doi.org/10.2147/IDR.S306441.
Mahat RK, Rathore V, Singh N, Singh N, Singh SK, Shah RK, et al. Lipid profile as an indicator of COVID-19 severity: a systematic review and meta-analysis. Clin Nutr ESPEN. 2021;45:91–101. https://doi.org/10.1016/j.clnesp.2021.07.023.
Cumhur Cure M, Cure E. Effects of the Na+/H+ ion exchanger on susceptibility to COVID-19 and the course of the disease. J Renin-Angiotensin-Aldosterone Syst. 2021;2021:4754440. https://doi.org/10.1155/2021/4754440.
Conrad KP. Might proton pump or sodium-hydrogen exchanger inhibitors be of value to ameliorate SARs-CoV-2 pathophysiology? Physiol Rep. 2021;8(24):e14649. https://doi.org/10.14814/phy2.14649.
Hendus-Altenburger R, Vogensen J, Pedersen ES, Luchini A, Araya-Secchi R, Bendsoe AH, et al. The intracellular lipid-binding domain of human Na+/H+ exchanger 1 forms a lipid-protein co-structure essential for activity. Commun Biol. 2020;3(1):731. https://doi.org/10.1038/s42003-020-01455-6.
Wang H, Yuan Z, Pavel MA, et al. The role of high cholesterol in age-related COVID19 lethality. bioRxiv [Preprint]. 2021:2020.05.09.086249. https://doi.org/10.1101/2020.05.09.086249.
Khanna P, Garg H. Covid and cholesterol (C&C): something to worry about or much ado about nothing? Trends Anaesth Crit Care. 2021;36:39–40. https://doi.org/10.1016/j.tacc.2020.09.003.
Cao X, Yin R, Albrecht H, Fan D, Tan W. Cholesterol: a new game player accelerating vasculopathy caused by SARS-CoV-2? Am J Physiol Endocrinol Metab. 2020;319(1):E197–202. https://doi.org/10.1152/ajpendo.00255.2020.
Zinellu A, Paliogiannis P, Fois AG, Solidoro P, Carru C, Mangoni AA. Cholesterol and triglyceride concentrations, COVID-19 severity, and mortality: a systematic review and Meta-analysis with Meta-regression. Front Public Health. 2021;9:705916. https://doi.org/10.3389/fpubh.2021.705916.
Aparisi Á, Iglesias-Echeverría C, Ybarra-Falcón C, Cusácovich I, Uribarri A, García-Gómez M, et al. Low-density lipoprotein cholesterol levels are associated with poor clinical outcomes in COVID-19. Nutr Metab Cardiovasc Dis. 2021;31(9):2619–27. https://doi.org/10.1016/j.numecd.2021.06.016.
Kraft ML. Sphingolipid Organization in the Plasma Membrane and the mechanisms that influence it. Front Cell Dev Biol. 2017;4:154. https://doi.org/10.3389/fcell.2016.00154.
Fecchi K, Anticoli S, Peruzzu D, Iessi E, Gagliardi MC, Matarrese P, et al. Coronavirus interplay with lipid rafts and autophagy unveils promising therapeutic targets. Front Microbiol. 2020;11:1821. https://doi.org/10.3389/fmicb.2020.01821.
Deng Y, Almsherqi ZA, Ng MM, Kohlwein SD. Do viruses subvert cholesterol homeostasis to induce host cubic membranes? Trends Cell Biol. 2010;20(7):371–9. https://doi.org/10.1016/j.tcb.2010.04.001.
Abu-Farha M, Thanaraj TA, Qaddoumi MG, Hashem A, Abubaker J, Al-Mulla F. The role of lipid metabolism in COVID-19 virus infection and as a drug target. Int J Mol Sci. 2020;21(10):3544. https://doi.org/10.3390/ijms21103544.
Baggen J, Vanstreels E, Jansen S, Daelemans D. Cellular host factors for SARS-CoV-2 infection. Nat Microbiol. 2021;6(10):1219–32. https://doi.org/10.1038/s41564-021-00958-0.
Kiaie N, Gorabi AM, Reiner Ž, Jamialahmadi T, Ruscica M, Sahebkar A. Effects of statins on renin-angiotensin system. J Cardiovasc Dev Dis. 2021;8(7):80. https://doi.org/10.3390/jcdd8070080.
Barkas F, Milionis H, Anastasiou G, Liberopoulos E. Statins and PCSK9 inhibitors: what is their role in coronavirus disease 2019? Med Hypotheses. 2021;146:110452. https://doi.org/10.1016/j.mehy.2020.110452.
Diaz-Arocutipa C, Melgar-Talavera B, Alvarado-Yarasca Á, Saravia-Bartra MM, Cazorla P, Belzusarri I, et al. Statins reduce mortality in patients with COVID-19: an updated meta-analysis of 147 824 patients. Int J Infect Dis. 2021;110:374–81. https://doi.org/10.1016/j.ijid.2021.08.004.
Leggio M, Villano A, Fusco A, Mazza A. Hyperlipidemia management during the COVID-19 pandemic: PCSK9 inhibitors to enhance the antiviral action of interferon. Eur Rev Med Pharmacol Sci. 2021;25(5):2166–7. https://doi.org/10.26355/eurrev_202103_25205.
Brown MS, Goldstein JL. A receptor-mediated pathway for cholesterol homeostasis. Science. 1986;232(4746):34–47. https://doi.org/10.1126/science.3513311.
Sviridov D, Bukrinsky M. Interaction of pathogens with host cholesterol metabolism. Curr Opin Lipidol. 2014;25(5):333–8. https://doi.org/10.1097/MOL.0000000000000106.
Gudleski-O'Regan N, Greco TM, Cristea IM, Shenk T. Increased expression of LDL receptor-related protein 1 during human cytomegalovirus infection reduces virion cholesterol and infectivity. Cell Host Microbe. 2012;12(1):86–96. https://doi.org/10.1016/j.chom.2012.05.012.
Nikolic J, Belot L, Raux H, Legrand P, Gaudin Y, Albertini A. Structural basis for the recognition of LDL-receptor family members by VSV glycoprotein. Nat Commun. 2018;9(1):1029. https://doi.org/10.1038/s41467-018-03432-4.
Verdaguer N, Fita I, Reithmayer M, Moser R, Blaas D. X-ray structure of a minor group human rhinovirus bound to a fragment of its cellular receptor protein. Nat Struct Mol Biol. 2004;11(5):429–34. https://doi.org/10.1038/nsmb753.
Syed GH, Tang H, Khan M, Hassanein T, Liu J, Siddiqui A. Hepatitis C virus stimulates low-density lipoprotein receptor expression to facilitate viral propagation. J Virol. 2014;88(5):2519–29. https://doi.org/10.1128/JVI.02727-13.
Abrass CK. Cellular lipid metabolism and the role of lipids in progressive renal disease. Am J Nephrol. 2004;24(1):46–53. https://doi.org/10.1159/000075925.
Cure E, Cumhur Cure M, Vatansev H. Central involvement of SARS-CoV-2 may aggravate ARDS and hypertension. J Renin-Angiotensin-Aldosterone Syst. 2020;21(4):1470320320972015. https://doi.org/10.1177/1470320320972015.
Schlüter KD, Wolf A, Schreckenberg R. Coming Back to physiology: extra hepatic functions of Proprotein convertase Subtilisin/Kexin type 9. Front Physiol. 2020;11:598649. https://doi.org/10.3389/fphys.2020.598649.
Strickland DK, Gonias SL, Argraves WS. Diverse roles for the LDL receptor family. Trends Endocrinol Metab 2002;13(2):66–74. https://doi.org/10.1016/s1043-2760(01)00526-4.
Sendra J, Llorente-Cortés V, Costales P, Huesca-Gómez C, Badimon L. Angiotensin II upregulates LDL receptor-related protein (LRP1) expression in the vascular wall: a new pro-atherogenic mechanism of hypertension. Cardiovasc Res. 2008;78(3):581–9. https://doi.org/10.1093/cvr/cvn043.
Li D, Singh RM, Liu L, Chen H, Singh BM, Kazzaz N, Mehta JL. Oxidized-LDL through LOX-1 increases the expression of angiotensin converting enzyme in human coronary artery endothelial cells. Cardiovasc Res 2003;57(1):238–243. https://doi.org/10.1016/s0008-6363(02)00674-0.
Slattery C, Jenkin KA, Lee A, Simcocks AC, McAinch AJ, Poronnik P, et al. Na+−H+ exchanger regulatory factor 1 (NHERF1) PDZ scaffold binds an internal binding site in the scavenger receptor megalin. Cell Physiol Biochem. 2011;27(2):171–8. https://doi.org/10.1159/000325219.
Ye F, Wang Y, Wu C, Howatt DA, Wu CH, Balakrishnan A, et al. Angiotensinogen and Megalin interactions contribute to atherosclerosis-brief report. Arterioscler Thromb Vasc Biol. 2019;39(2):150–5. https://doi.org/10.1161/ATVBAHA.118.311817.
Murtazina R, Kovbasnjuk O, Donowitz M, Li X. Na+/H+ exchanger NHE3 activity and trafficking are lipid raft-dependent. J Biol Chem. 2006;281(26):17845–55. https://doi.org/10.1074/jbc.M601740200.
Elsing C, Kassner A, Stremmel W. Effect of surface and intracellular pH on hepatocellular fatty acid uptake. Am J Phys. 1996;271(6 Pt 1):G1067–73. https://doi.org/10.1152/ajpgi.1996.271.6.G1067.
Hamilton JA, Civelek VN, Kamp F, Tornheim K, Corkey BE. Changes in internal pH caused by movement of fatty acids into and out of clonal pancreatic beta-cells (HIT). J Biol Chem. 1994;269(33):20852–6. https://doi.org/10.1016/S0021-9258(17)31900-2.
Civelek VN, Hamilton JA, Tornheim K, Kelly KL, Corkey BE. Intracellular pH in adipocytes: effects of free fatty acid diffusion across the plasma membrane, lipolytic agonists, and insulin. Proc Natl Acad Sci U S A. 1996;93(19):10139–44. https://doi.org/10.1073/pnas.93.19.10139.
Ogihara T, Asano T, Ando K, Chiba Y, Sakoda H, Anai M, et al. Angiotensin II-induced insulin resistance is associated with enhanced insulin signaling. Hypertension. 2002;40(6):872–9. https://doi.org/10.1161/01.hyp.0000040262.48405.a8.
Govender N, Khaliq OP, Moodley J, Naicker T. Insulin resistance in COVID-19 and diabetes. Prim Care Diabetes. 2021;15(4):629–34. https://doi.org/10.1016/j.pcd.2021.04.004.
Jimenez L, Campos Codo A, Sampaio VS, et al. Acid pH Increases SARS-CoV-2 Infection and the Risk of Death by COVID-19. Front Med (Lausanne). 2021;8:637885. https://doi.org/10.3389/fmed.2021.637885.
Sarigianni M, Tsapas A, Mikhailidis DP, Kaloyianni M, Koliakos G, Fliegel L, et al. Na+ H+ exchanger-1: a link with atherogenesis? Expert Opin Investig Drugs. 2010;19(12):1545–56. https://doi.org/10.1517/13543784.2010.532123.
Yamamoto S, Matsui K, Itoh N, Ohashi N. The effect of an Na+/H+ exchange inhibitor, SM-20550, on ischemia/reperfusion-induced endothelial dysfunction in isolated perfused rat hearts. Int J Tissue React. 2001;23(1):1–7.
Benjannet S, Saavedra YG, Hamelin J, Asselin MC, Essalmani R, Pasquato A, et al. Effects of the prosegment and pH on the activity of PCSK9: evidence for additional processing events. J Biol Chem. 2010;285(52):40965–78. https://doi.org/10.1074/jbc.M110.154815.
Tibolla G, Norata GD, Artali R, Meneghetti F, Catapano AL. Proprotein convertase subtilisin/kexin type 9 (PCSK9): from structure-function relation to therapeutic inhibition. Nutr Metab Cardiovasc Dis. 2011;21(11):835–43. https://doi.org/10.1016/j.numecd.2011.06.002.
Schulz R, Schlüter KD. PCSK9 targets important for lipid metabolism. Clin Res Cardiol Suppl. 2017;12(Suppl 1):2–11. https://doi.org/10.1007/s11789-017-0085-0.
Nofer JR, Noll C, Feuerborn R, Assmann G, Tepel M. Low density lipoproteins inhibit the Na+/H+ antiport in human platelets via activation of p38MAP kinase. Biochem Biophys Res Commun. 2006;340(3):751–7. https://doi.org/10.1016/j.bbrc.2005.12.070.
Chang HB, Gao X, Nepomuceno R, Hu S, Sun D. Na(+)/H(+) exchanger in the regulation of platelet activation and paradoxical effects of cariporide. Exp Neurol. 2015;272:11–6. https://doi.org/10.1016/j.expneurol.2014.12.023.
Department of Internal Medicine, Bagcilar Medilife Hospital, 34200, Istanbul, Turkey
Erkan Cure
Department of Biochemistry, Private Kucukcekmece Hospital, Istanbul, Turkey
Medine Cumhur Cure
EC and MCC wrote this editorial entirely. The authors read and approved the final manuscript.
Correspondence to Erkan Cure.
Cure, E., Cumhur Cure, M. Strong relationship between cholesterol, low-density lipoprotein receptor, Na+/H+ exchanger, and SARS-COV-2: this association may be the cause of death in the patient with COVID-19. Lipids Health Dis 20, 179 (2021). https://doi.org/10.1186/s12944-021-01607-5
Na+/H+ exchanger
PCSK9


text:
Thu, 05 Dec, 2019 - 21:15
Cork heroin wholesaler has his jail sentence cut by four years
Garrett Hill: Sentence cut from 17 years to 13 years.Pic Michael Mac Sweeney/Cork Courts
A heroin wholesaler living in Blarney who was 'brazen' in preparing drugs for sale in his kitchen even though he knew gardaí were calling to check his curfew on another drugs case had his sentence of 17 years reduced to 13 years yesterday.
Mr Justice John Edwards said at the Court of Appeal sitting in Cork that the sentence was disproportionate and effectively reduced it by four years today.
Judge Brian O'Callaghan imposed the original sentence on Garrett Hill, 38, at Cork Circuit Criminal Court. Consecutive sentences of seven and ten years were imposed on the accused who had not shown a scintilla of remorse for his crimes which had a devastating effect on society, the judge said.
Garrett Hill of The View, Gleann Na Rí, Tower, Blarney, pleaded at Cork Circuit Criminal Court to charges of having heroin for sale or supply at Cork Builders Providers car park in Togher on August 25, 2016, and having heroin for sale or supply at an apartment at Blarney shopping centre on the same date.
Anthony Sammon defence senior counsel said not enough credit was given for Hill's plea of guilty. He said that even though it came after the trial had opened it obviated the necessity for the State to call evidence from undercover officers whose identity was kept hidden.
Hill was sentenced for two different incidents of drug-dealing – the second happening at a time when gardaí were calling regularly to his house to check he was keeping his curfew. They saw him – through a window – weighing and bagging drugs for sale in his kitchen.
Mr Justice George Birmingham said that showed brazenness. Mr Sammon said he had to agree it showed "a considerable amount of neck." Mr Sammon objected to comments made by Judge Brian O'Callaghan at the sentencing hearing that educational courses taken by Hill in prison might serve to "make him a better criminal." Mr Sammon SC said, "These comments were deeply offensive and should not have been made by the sentencing judge."
Originally from Drogheda and married with a family in Blarney he was described as organiser-in-chief of the drug-dealing detected by gardaí.
Over €7,000 worth of heroin was found in the car in Togher in August 2016 and more than €96,000 worth in an apartment at Blarney shopping centre. In January 2017 at his home gardaí seized almost €13,000 worth of drugs for sale or supply, consisting mainly of cannabis on that occasion but also of cocaine and heroin.
Detective Garda Ian Cahalane testified that when interviewed by gardaí on six separate occasions in relation to drug-dealing in August 2016 and January 2017, Hill replied 'No comment' to every relevant question.
courtcorkdrug dealingsentencegarrett hillcork garda

redpajama_set_name: RedPajamaCommonCrawl


text:
Der Bogenzusammenhang ist ein Grundbegriff der Graphentheorie und eine Verallgemeinerung des Zusammenhangs für gerichtete Graphen (Digraphen). Anschaulich ist der Bogenzusammenhang ein Maß dafür, wie schwer es ist, einen Digraphen durch Löschen von gerichteten Kanten in zwei oder mehr Komponenten zu zerlegen. Ist der Bogenzusammenhang groß, so müssen viele gerichtete Kanten entfernt werden.

Definition

Ein gerichteter Graph , der stark zusammenhängend ist, heißt k-fach bogenzusammenhängend oder k-bogenzusammenhängend, wenn der Graph  für alle Kantenmengen  der Mächtigkeit  stark zusammenhängend ist.

Das größte , so dass  k-fach bogenzusammenhängend ist, heißt Bogenzusammenhangszahl und wird mit  bezeichnet.

Ist  trivial oder nicht stark zusammenhängend, so nennt man ihn 0-fach bogenzusammenhängend und setzt

Beispiel

Betrachte als Beispiel den rechts abgebildeten gerichteten Graphen. Dieser ist nicht trivial und stark zusammenhängend, also ist der Graph auf jeden Fall 1-bogenzusammenhängend. Beginnt man mit dem Löschen von einelementigen Kantenmengen (z. B. der Kante ), so wird der starke Zusammenhang zerstört (Nach dem Löschen der Kante kann der Knoten 1 nicht mehr vom Knoten 4 aus erreicht werden). Demnach ist der Graph nicht 2-bogenzusammenhängend und es ist , da der Graph 0-bogenzusammenhängend und 1-bogenzusammenhängend ist.

Algorithmen

Zur Bestimmung der Bogenzusammenhangszahl gibt es polynomielle Algorithmen. Dazu kann man beispielsweise Flussalgorithmen verwenden. Ist als  der Aufwand, einen minimalen Schnitt im Graphen bestimmen, so hat dieser naive Ansatz immerhin einen Aufwand von . Es gibt noch deutlich effizientere, aber auch kompliziertere Algorithmen.

Verwandte Begriffsbildungen

Ein Analogon des Bogenzusammenhangs für ungerichtete Graphen ist der Kantenzusammenhang. Hier werden ungerichtete Kanten entfernt, bis der Graph in seine Zusammenhangskomponenten zerfällt. Des Weiteren gibt es den Begriff des k-Zusammenhangs, welcher ein Maß dafür ist, wie viele Ecken aus einem Graphen entfernt werden müssen, damit er in seine Komponenten zerfällt.

Literatur

 Lutz Volkmann: Fundamente der Graphentheorie, Springer (Wien) 1996, ISBN 3-211-82774-9 (neuere, Online-Version "Graphen an allen Ecken und Kanten"; PDF; 3,7 MB)

Grundbegriff (Graphentheorie)

redpajama_set_name: RedPajamaWikipedia


text:
CJEU Joined Cases C‑542/18 RX-II and C‑543/18 RX-II / Judgment
Erik Simpson and HG v Council of the European Union and European Commission
Coiurt (Grand Chamber)
ECLI (European case law identifier)
ECLI:EU:C:2020:232
Article 47 - Right to an effective remedy and to a fair trial
Review of the judgments of the General Court of the European Union in Simpson v Council (T‑646/16 P) and HG v Commission (T‑693/16 P) — Civil service — Composition of the panel of judges which delivered the judgments at first instance — Procedure for the appointment of a judge to the European Union Civil Service Tribunal — Article 47 of the Charter of Fundamental Rights of the European Union — Tribunal established by law — Incidental review of legality — Effect on the unity and consistency of EU law.
Outcome of the case:
On those grounds, the Court (Grand Chamber) hereby:
Orders that Cases C‑542/18 RX‑II and C‑543/18 RX‑II be joined for the purposes of the judgment;
Declares that the judgments of the General Court of the European Union (Appeal Chamber) of 19 July 2018, Simpson v Council (T‑646/16 P, not published, EU:T:2018:493) and HG v Commission (T‑693/16 P, not published, EU:T:2018:492) affect the unity and consistency of EU law in so far as the General Court, as court of appeal, held that the composition of the panel of judges of the European Union Civil Service Tribunal which had delivered the order of 24 June 2016, Simpson v Council (F‑142/11 RENV, EU:F:2016:136) and the judgment of 19 July 2016, HG v Commission (F‑149/15, EU:F:2016:155), respectively, had been irregular, on the basis of an irregularity affecting the procedure for the appointment of one of the members of that panel of judges, leading to a breach of the principle of the lawful judge, laid down in the first sentence of the second paragraph of Article 47 of the Charter of Fundamental Rights of the European Union, and set aside those decisions;
Sets aside those judgments;
Refers the cases back to the General Court of the European Union;
Orders Mr Erik Simpson, the Council of the European Union, HG, the European Commission and the Bulgarian Government to bear their own costs in relation to the review proceedings.
4) The review concerns the question whether, having regard, in particular, to the general principle of legal certainty, the judgments under review affect the unity or consistency of EU law in so far as the General Court, as court of appeal, held that the composition of the panel of judges of the Civil Service Tribunal which had made the order of 24 June 2016, Simpson v Council (F‑142/11 RENV, EU:F:2016:136), and the judgment of 19 July 2016, HG v Commission (F‑149/15, EU:F:2016:155) (together, 'the contested decisions'), had been irregular, on the basis of an irregularity affecting the procedure for the appointment of one of the members of that panel of judges, leading to a breach of the principle of the lawful judge, laid down in the first sentence of the second paragraph of Article 47 of the Charter of Fundamental Rights of the European Union ('the Charter').
6) Article 47 of the Charter, entitled 'Right to an effective remedy and to a fair trial', states, in the first and second paragraphs thereof:
'Everyone whose rights and freedoms guaranteed by the law of the Union are violated has the right to an effective remedy before a tribunal in compliance with the conditions laid down in this Article.
Everyone is entitled to a fair and public hearing within a reasonable time by an independent and impartial tribunal previously established by law. Everyone shall have the possibility of being advised, defended and represented.'
43) Thirdly, in paragraph 78 of the judgment of 23 January 2018, FV v Council (T‑639/16 P, EU:T:2018:22), the General Court held that in the light of the importance of observing the rules governing the appointment of a judge with regard to litigants' confidence and that of the public in the independence and impartiality of courts and tribunals, the judge concerned could not be regarded as a judge assigned by law for the purposes of the first sentence of the second paragraph of Article 47 of the [Charter] and, therefore, set aside the judgment of 28 June 2016, FV v Council (F‑40/15, EU:F:2016:137) in its entirety.
46) Accordingly, the order under appeal must be set aside in its entirety on the grounds of infringement of the principle of the right to a judge assigned by law, enshrined in the first sentence of the second paragraph of Article 47 of the [Charter], without it being necessary to examine the grounds of appeal raised by the appellant.'
50) As regards the answer to the question to be reviewed in this case, it is necessary to begin by examining whether, having regard, in particular, to the general principle of legal certainty, the General Court erred in law by setting aside the contested decisions on the ground that the composition of the panel of judges of the Civil Service Tribunal which had delivered those decisions had been irregular because of an irregularity affecting the procedure for the appointment of one of the members of that panel of judges, leading to a breach of the principle of the lawful judge, laid down in the first sentence of the second paragraph of Article 47 of the Charter.
51) In the context of that examination, it is necessary to determine, first, in what circumstances the appointment of a judge may, like acts covered by Article 277 TFEU, form the subject matter of an incidental review of legality. Secondly, the Court must verify whether, in so far as the irregularity concerning the appointment procedure is established, as determined by the General Court, that irregularity did indeed lead to an infringement of the first sentence of the second paragraph of Article 47 of the Charter, justifying the setting aside of those decisions.
55) However, it follows from the fundamental right to an effective remedy before an independent and impartial tribunal previously established by law, guaranteed by Article 47 of the Charter, that everyone must, in principle, have the possibility of invoking an infringement of that right. Accordingly the Courts of the European Union must be able to check whether an irregularity vitiating the appointment procedure at issue could lead to an infringement of that fundamental right.
69) In the judgments under review, the General Court, again relying on the judgment of 23 January 2018, FV v Council (T‑639/16 P, EU:T:2018:22), held that in the light of the importance of observing the rules governing the appointment of a judge with regard to litigants' confidence and that of the public in the independence and impartiality of courts and tribunals, the judge appointed to the third post could not be regarded as a lawful judge for the purposes of the first sentence of the second paragraph of Article 47 of the Charter.
72) Since the first sentence of the second paragraph of Article 47 of the Charter corresponds to the first sentence of Article 6(1) of the Convention for the Protection of Human Rights and Fundamental Freedoms, signed in Rome on 4 November 1950 ('ECHR'), its meaning and scope are, in accordance with Article 52(3) of the Charter, the same as those laid down by that convention. The Court must therefore ensure that the interpretation which it gives to the second paragraph of Article 47 of the Charter safeguards a level of protection which does not fall below the level of protection established in Article 6 ECHR, as interpreted by the European Court of Human Rights (judgment of 19 November 2019, A. K. and Others(Independence of the Disciplinary Chamber of the Supreme Court), C‑585/18, C‑624/18 and C‑625/18, EU:C:2019:982, paragraph 118 and the case-law cited).
75) It follows from the case-law cited in paragraphs 71 and 73 of the present judgment that an irregularity committed during the appointment of judges within the judicial system concerned entails an infringement of the first sentence of the second paragraph of Article 47 of the Charter, particularly when that irregularity is of such a kind and of such gravity as to create a real risk that other branches of the State, in particular the executive, could exercise undue discretion undermining the integrity of the outcome of the appointment process and thus give rise to a reasonable doubt in the minds of individuals as to the independence and the impartiality of the judge or judges concerned, which is the case when what is at issue are fundamental rules forming an integral part of the establishment and functioning of that judicial system.
76) It is in the light of those principles that the Court must examine whether the irregularity committed in the appointment procedure at issue resulted in this instance in an infringement of the parties' right to a hearing by a tribunal previously established by law, as guaranteed by the first sentence of the second paragraph of Article 47 of the Charter.
81) It follows from the foregoing that the Council's disregard for the public call for applications of 3 December 2013 does not constitute an infringement of the fundamental rules of EU law applicable to the appointment of judges to the Civil Service Tribunal that entailed an infringement of the applicants' right to a tribunal established by law, as guaranteed by the first sentence of the second paragraph of Article 47 of the Charter.
82) Consequently, and since the judgments under review do not contain anything else that might cast doubt on compliance with the first sentence of the second paragraph of Article 47 of the Charter, it must be held that the General Court made an error of law in ruling, in those judgments, that that provision had been infringed. The irregularity referred to in the preceding paragraph could not, therefore, by itself justify the setting aside of a judicial decision adopted by the panel of judges to which the judge appointed to the third post was assigned.
85) The judgments under review could constitute precedents for future cases, since the General Court's erroneous interpretation and application of the first sentence of the second paragraph of Article 47 of the Charter could have repercussions for other cases in which the appointment of a member of a panel of judges and, more generally, the right to an independent and impartial tribunal previously established by law is put in issue.
87) In those circumstances, it must be held that the judgments under review affect the unity and consistency of EU law in so far as the General Court, as court of appeal, held that the composition of the panel of judges of the Civil Service Tribunal which had delivered the contested decisions had been irregular, on the basis of an irregularity affecting the procedure for the appointment of one of the members of that panel of judges, leading to a breach of the principle of the lawful judge, laid down in the first sentence of the second paragraph of Article 47 of the Charter, and set aside those decisions.
90) Since, in the judgments under review, the General Court set aside the contested decisions on the basis of an infringement of the first sentence of the second paragraph of Article 47 of the Charter without examining the grounds of appeal which the appellants had put forward in their respective appeals, the judgments under review must be set aside and the cases referred back to the General Court in order for it to rule on those grounds of appeal.
92) Since there are no specific rules governing orders for costs in the case of a review, the parties must be ordered to bear their own costs.


text:
Q: solving the dimensions of a triangular prism 3 rectangular faces of a triangular prism have areas of 30, 40, 50. 2 triangular faces have a combined area of 12. What are the dimensions of the prism?

A: You can deduce that the area of one of the triangles if 6.
You also know the triangle sides are in proportion of $3:4:5$ with each other.  So you could say the lengths are $3x,4x,5x$.
Generally, from there you could use Heron's Formula to find the sides. But, knowing about triangles, you might be able to come up with the sides without using the formula.

redpajama_set_name: RedPajamaStackExchange


Semantic Drupal Page 193: 54 Of À Jour Meuble Mural Chambre. 56 Of À Jour Meuble Semainier. 59 Of Élégant Eclairage sous Meuble Cuisine. 68 Of À Jour Le Bon Coin Meuble Occasion 95. 66 Of À La Mode Meuble Bois Salle De Bain. 72 Of À Jour Creation Meuble.
Thursday 12th, July 2018 15:33:51: PM. Meuble.. Laura Kennedy.
Thursday 12th, July 2018 12:21:51: PM. Meuble.. Danielle Pierce.
Thursday 12th, July 2018 10:24:51: AM. Meuble.. Brenda Williamson.
Thursday 12th, July 2018 08:27:51: AM. Meuble.. Jacob Morales.
Thursday 12th, July 2018 07:32:51: AM. Meuble.. Laura Kennedy.
Thursday 12th, July 2018 06:35:51: AM. Meuble.. sonna alabasta.
Thursday 12th, July 2018 04:51:51: AM. Meuble.. Danielle Pierce.
Thursday 12th, July 2018 04:11:51: AM. Meuble.. Susan Carpenter.
Thursday 12th, July 2018 03:06:51: AM. Meuble.. Laura Kennedy.
Thursday 12th, July 2018 02:12:51: AM. Meuble.. Susan Carpenter.


All Petty Pool students are given the opportunity to get involved in residential trips to further develop core skills in a range of different environments. We organise residentials which include trips to London by train, visits to Ribby Hall Village, Haven Holidays camps and our annual Turkey and Tinsel event in Lytham.
We also provide on-site 'baseline' residentials for all students at the beginning of the year. This enables us to establish baseline skills and capabilities, such as making the bed, packing, on-site safety awareness etc, which we then use to develop targets for the coming year.
Students participate in a range of fun and accessible day trips throughout the year to further develop their independent living skills outside of the college environment. From shopping trips to the local supermarket and pantomimes at Warrington and Vale Royal College, to Christmas carol singing – each provides ample opportunity to practice the core social and independent living skills they need to take them forward into adulthood.
At Petty Pool, we're lucky enough to be surrounded by acres of gorgeous Cheshire countryside, as well as our state of the art Outdoor Centre. Throughout the year, students enjoy many outdoor pursuits, including bushcraft, zip wire and archery – enabling them to enjoy the great outdoors in a safe, nurturing environment.
Special events include an annual ice rink installed in the grounds during the Christmas term, and our annual Halloween party. We've even hosted a Summer music festival in our grounds, at the request of our students – something we plan to repeat in coming years.
We recognise and value the importance of the voice of the students. To facilitate this, we create opportunities for young people to play meaningful roles at an operational level, thereby making young people an integral part of decisions and governance arrangements.
Learner rights and autonomy are actively championed at Petty Pool. At the heart of this is our student council, which consists of two reps from each class who are elected by their peers.
A focus on developing a strong learner voice through the student council and monthly learner forums are key in preparing learners for life after college.
Without a doubt, the highlight of our social calendar at Petty Pool is the annual student prom. This special event is held in July to recognise the achievements of students who are leaving the college, but is open to all students and parents / carers who wants to attend. It's a great opportunity to get dressed up, jump in a limo, dance all night, and most importantly, celebrate our leavers' many achievements. The night includes a presentation to each Petty Pool graduate – and a moment to shine a spotlight on the stars of the show – our students.


Fuel Cell Systems offer high efficiency, quiet, clean, low signature power generation. To be useful for military applications they must use commonly available logistic fuels: JP8 is the primary fuel of choice. This paper reports the results of 1000 hour tests of innovative hardware to desulfurize and reform JP8. Results from early testing of a 6 kW fully integrated PEM fuel cell system operating on JP8 are also presented.


The RAS publishes results of original research in its major journals, Monthly Notices of the Royal Astronomical Society (MNRAS) and Geophysical Journal international (GJI). Astronomy & Geophysics (A&G) is the Society's full-colour news and reviews magazine, distributed to all Fellows.
Meet the team of Editors and Assistant Editors who work on our journals.


SKODA SERVICING, REPAIRS & MOT.
*We will contact your shortly after your booking in order to confirm your requested availability date and time, as well as availability of a courtesy car (if required) in addition to any other details regarding your booking.
Our award winning customer service is with you every single mile you drive. At Rainworth SKODA, we believe in supporting you and your car throughout your ownership, which is why we deliver an extensive range of aftersales services that are second to none.
When you book your service or MOT with Rainworth SKODA, we'll show you exactly what we see in the workshop using our Electronic Visual Health Check system. We'll email you a short video, highlighting the current condition of your car from a technician's eye.
Once you've recieved your Video Health Check, we'll give you a call to discuss our findings and any necessary work we feel needs to be carried out. Any work approved will be then carried out as swiftly as possible, and we'll keep you up to date, every step of the way.
Once we have completed the work, we'll then show you the changes by giving you a full, final health check of your vehicle – so you can be sure your car has a colean bill of health and is as safe to drive as it was when it was new.
The minor service is a comprehensive check to ensure that your vehicle remains at optimal efficiency between routine Major Services, providing you with peace of mind that your vehicle is safe and reliable.
The major service is a complete overhaul, replacing all wear and tear items such as oil and filters. We also check the belts, make adjustments where necessary and give your brakes, gearbox and suspension a full inspection, alongside an extensive diagnostics report.
A simple, fixed, low price of only £39 to provide your car with a full MOT for the year. Give us a call on 01623 709832 to get your car booked in.
Brake pads are available from as little as £115. All prices include supply and fitment by a SKODA technician. If you are experiencing any issues under braking, such as unusual noises, vibrations or any other symptoms you are concerned about, please contact us on 01623 623400 for advice.
Overtime, your car's battery can lose it's capacity, effectiveness and overall charge. A brand new SKODA battery can cost as little as £115 fitted.
A clutch is a vital part of the transmissions system. Their lifespan varies depending on usage and driving style. If the biting point your clutch is low on the pedal, it may mean that your clutch is due for replacement. If you're unsure, contact our after sales team on 01623 623400 who'll help you diagnose any issues.
The cam belt (or timing belt) is fundamental in keeping your engine running. Wear and tear over time means that the rubber can perish and form small cracks. To avoid component failure we always recommend replacement of the cam belt by genuine SKODA parts, fitted by a trained SKODA technician.
A SERVICE PLAN TAILOR-MADE FOR BOTH YOU AND YOUR VEHICLE.
Spread the cost of your servicing with our Platinum Service Club Service Plan. It offers a hassle-free, easy way to budget for all your servicing needs. You can spread the cost of your car insurance and your road tax, now you can spread the cost of your servicing! The best thing? It includes the cost of all your MOT tests too!
You can take out a Service Plan at any time of vehicle ownership, and if you decide to change your vehicle before the end of the term of your plan, you can easily just transfer it straight onto your new car!
Great, Let's get you signed up!
Enter your contact details below, and one of our after sales team will contact you to get you signed up.
The Service Plan covers the complete cost of your annual servicing, including parts and labour, you can also choose to include normal wear and tear parts such as bulbs, brake pads and windscreen wipers etc.
For higher mileage customers that require more than one service per annum, we will prepare a quotation individually.
Prices start from only £17.99 per month with 90% of our customers paying less then £19.95 per month.
You choose whether to include a cambelt, brake fluid change, tyres etc in to your policy.
Platinum Service Plan policies are transferable when buying your car from us.
Secure the value of your part exchange with a Platinum Service Plan.
You can spread the cost with easy monthly payments with no interest to pay – so you won't have to face an inconvenient bill (If you prefer, you can pay in one lump sum).
So, not only will you be able to budget easily for the cost of servicing, you could also save money. The servicing costs of your vehicle are frozen on the say you take out the plan, so you don't need to worry about price rises during the term of your Service Plan.
Contact John Evans on 01623 623400 for full details.
Your vehicle will be maintained and serviced by our professional trained technicians. And what's more, a fully stamped service book will help to maintain your vehicles resale value.
Pay the full amount initially by cash, credit or debit card.
Rainworth SKODA have a vast selection of tyres available to fit your car, requirements and your budget – even if it's not in stock, we'll get it delivered ASAP. From specialists snow and winter tyres, to all season and summer tyres, we can supply and fit them all. We supply a wide range of manufacturers, from Dunlop and Michelin, to Pirrelli and Continental, and best still, our prices start from only £51.99 including balancing and fitting.
Select your tyre size from below to see our highlighted tyres in the range available to suit your car. Remember, we have a wide variety available and supply with experts on hand to advise on the right tyre for you.
*Prices shown are from prices, and are inclusive of VAT, fitting and balancing.
Various brands, sizes and prices are available to order.
*Prices shown are inclusive of VAT.


text:
Q: Find simple text fragment in packets Trying to filter packets with Wireshark. Why it finds nothing when placing filter tcp contains M-SEARCH. I have such value on the third line.

A: SSDP uses UDP as the underlying transport protocol. You are filtering on TCP.
https://en.wikipedia.org/wiki/Simple_Service_Discovery_Protocol#Protocol_transport_and_addressing
Try matching UDP text instead.


text:
Q: AWS SAM CLI local invoke account id not set when --profile is passed as parameter I'm trying to execute aws sam local invoke command in order to test my function locally. The problem occurs when I run this command passing profile parameter. The execution container sets account id as a dummy account like 123456789012
Does anybody knows If there is any thing cached here? When I deploy my project using sam deploy --guided everything runs perfect and code is uploaded to AWS
my ~/.aws/config and ~/.aws/credentials files are filled
credentials
[adm]
aws_access_key_id=XXXXXXXXXXXXXx
aws_secret_access_key=XXXXXXXXXXXXXXXXXX

config
[adm]
region = eu-west-1
output = json

➜  POC sam local invoke "ScheduleBusinessRuleFunction"  --profile adm
Invoking scheduleBusinessRule (go1.x)
Skip pulling image and use local one: amazon/aws-sam-cli-emulation-image-go1.x:rapid-1.18.1.

Mounting /run/media/urkob/projects/Projects/POC/.aws-sam/build/ScheduleBusinessRuleFunction as /var/task:ro,delegated inside runtime container
START RequestId: bc99de19-290b-46fa-908a-744d54547cbe Version: $LATEST
operation error CloudWatch Events: PutTargets, https response error StatusCode: 400, RequestID: 8e335486-de38-49bb-a06e-8090e26e9628, api error AccessDeniedException: Access to the resource arn:aws:lambda:us-east-1:123456789012:function:POC-executeBusinessRule is denied. Reason: Adding cross-account target is not permitted.: OperationError
null
END RequestId: bc99de19-290b-46fa-908a-744d54547cbe
REPORT RequestId: bc99de19-290b-46fa-908a-744d54547cbe  Init Duration: 0.14 ms  Duration: 1415.60 ms    Billed Duration: 1500 ms        Memory Size: 128 MB    Max Memory Used: 128 MB
{"errorMessage":"operation error CloudWatch Events: PutTargets, https response error StatusCode: 400, RequestID: 8e335486-de38-49bb-a06e-8090e26e9628, api error AccessDeniedException: Access to the resource arn:aws:lambda:us-east-1:123456789012:function:POC-executeBusinessRule is denied. Reason: Adding cross-account target is not permitted.","errorType":"OperationError"}%
➜  POC

UPDATED: 21/02/16
I've been searching what could be the problem. I'm using aws-sdk-go-v2 the example they exposed in ther official github documentation to get an instance of configuration:
I tryied two ways of getting config instance as you can see in this piece of code, the line commented and the line that comes after that is not commented.
import (
    "context"

    "github.com/aws/aws-sdk-go-v2/config"
    "github.com/aws/aws-sdk-go-v2/service/cloudwatchevents"
)

//NewCloudWatchService scheduler service
func NewCloudWatchService() CWEPutEventsAPI {
    cfg, err := config.LoadDefaultConfig(context.TODO())
    //Happens the same in local with this line
    // cfg, err := config.LoadDefaultConfig(context.TODO(), config.WithSharedConfigFiles(config.DefaultSharedCredentialsFiles))
    if err != nil {
        panic("configuration error, " + err.Error())
    }

    return cloudwatchevents.NewFromConfig(cfg)
}

This is my template.yaml file. I'm developing usin AWS SAM yaml templates. As you can see I reference ExecuteLambda in ScheduleLambda using GettAtt method but when the code runs in local the region and accountId are always the same: default values.
AWSTemplateFormatVersion: "2010-09-09"
Transform: AWS::Serverless-2016-10-31
Globals:
  Function:
    Timeout: 5

Resources:
  ScheduleBusinessRuleFunction:
    Type: AWS::Serverless::Function
    Properties:
      FunctionName: POC-scheduleBusinessRule
      CodeUri: functions/scheduleBusinessRule/
      Handler: scheduleBusinessRule
      Runtime: go1.x
      MemorySize: 128
      Timeout: 10
      Tracing: Active
      Role: !GetAtt SchedulerRole.Arn
      Environment:
        Variables:
          LAMBDA_ARN: !GetAtt ExecuteBusinessRuleFunction.Arn
          EVENT_BUS: "default"

  ExecuteBusinessRuleFunction:
    Type: AWS::Serverless::Function
    Properties:
      FunctionName: POC-executeBusinessRule
      CodeUri: functions/executeBusinessRule/
      Handler: executeBusinessRule
      Runtime: go1.x
      MemorySize: 128
      Tracing: Active


Helping birth parents in the Grand Canyon state through adoptions is what Lifetime Adoption does best. We have aided with successful adoptions all over the United States for more than 30 years. We want to make your adoption experience a pleasant one. Call us today at 1-800-923-6784 to have all of your questions answered.
Adoption in Arizona is an excellent way to provide a stable home life to a child even if you are not personally able. Adoptive parents go through a rigorous screening process to ensure every adopted child has the best possible family.
You can begin by looking through our online database of hopeful future parents. You will see many couples and singles looking for an open adoption in Arizona, throughout the southwestern United States and beyond. Reading these profiles, you will see that families come from all races, religions, backgrounds, and interests. The one thing they all have in common is the desire to open their homes to a new child.
As the birth mother, you are able to make as many choices as you need. You can choose your baby's adoptive parents. You can decide how involved they are with your pregnancy. You can even sign the baby's original birth certificate, giving him or her the name of your choice before the adoption in Arizona is completed.
An important choice that is yours to make is the scope of the adoption. You can choose to have a closed adoption, which means you and the child have no further contact at the time of the adoption. On the other hand, you can choose an open adoption, which is strongly encouraged by Lifetime Adoption. Open adoptions allow you to continue to have a relationship with the child, even after he or she lives with the new family. This can mean that you receive occasional photos or phone calls. It could also mean that you can visit the child and watch him or her grow. This is entirely up to you.
Lifetime Adoption was founded by an adoptive mother who knows the trials and struggles that sometimes come with adoptions. We thoroughly believe that families are better served by experiencing open adoptions. Adopted children have a higher sense of self-worth and grow up to be more successful when they have early access to birth parents.
When going through the adoption process, birth parents and adoptive parents will work together to ensure all involved feel confident in the decisions made. We encourage you to think about what would be best for your family, but also to remain flexible.
Call us now at 1-800-923-6784 or fill out our free online application to learn more about adoption in Arizona today.


text:
Q: jQuery header click BUT not an anchor inside I have some mark-up like:
Header Filter
and some code like:
$('.uiGridHeader th').click(theadClick); however I want to say if its the anchor that is clicked then DON'T do the function! The trigger also needs to happen on the TH so I can't add an addition span to add the trigger on.
I've had a look at the jquery not api but not quite sure how to use it when passing a function call inside the click method.
I also have some actions on the anchor link so any prevention needs to allow the anchor to still execute code!

A: Either prevent the click event from bubbling when the a element was clicked:
$('.uiGridHeader th a.uiFilter').click(function(event) {
    event.stopPropagation();
});

or test which element was clicked:
$('.uiGridHeader th').click(function(event) {
    if(event.target === this) {
        theadClick.call(this, event)
    }
});

Update: If you bind any event handlers with .live or .delegate, then you have to use the second approach as these methods do not bind the event handler to the element itself, but the some ancestor of the element (or the document root).
Update 2: If you have a more complicated nested structure, such as
Header Filter

you have to use some more jQuery trickery for the testing. For example, in the above case you could do:
$(event.target).closest('a.uiFilter', this).length === 0

This tests whether the clicked element is a.uiFilter itself or inside of it. The expression evaluates to true if not. The second parameter passed to closest restricts the search to the elements inside of this which is the table header element.

A: You can bind a click event handler to the a and stop the propagation of the event:
$(".uiFilter").click(function(e) {
    e.stopPropagation();
});

That will stop the event from bubbling up to the th element, which in turn means that any click event handlers bound to that (or any other ancestor elements) will not be executed.


text:
Prep shops offer easier ways to race
Mazda Motorsports
By MazdaMotorsports.com December 11, 2017 6:54 PM
By MazdaMotorsports.com | December 11, 2017 6:54 PM ET
Prep Shops are spread around the country, offering a variety of ways to concentrate on driving, without worrying about the logistics
A few weeks ago we took a look at the racecar rental market, especially with Spec Miata. There are a ton of shops out there with ready-to-go fleets of rentals. All you have to do is show up and drive.
Still, there are those who prefer to own their own racecar. They want it to fit like a glove and look the way they want it. However, like those who seek to rent, they may not have the time or other necessary resources (shop space, trailer, etc.) to do everything themselves. For them, the prep shop comes into play providing everything but the car.
"I think that with today's mentality, the way people are, nobody has time to play with their own race car," says Dave Wheeler, owner of Advanced Autosports in Beloit, Wis. "So for the people that have the money, it's well worth it. They have all of the advantages of a big-time shop without the commitment." Wheeler says he currently has about 37 cars in his shop that belong to customers – cars he brings to the track and for which he provides trackside support. He says he doesn't know if his program is going to grow for 2018, but he's pretty sure it's not going to shrink.
Adds Nick Leverone of Flatout Motorsports in Massachusetts: "I think as the economy gets better, obviously the expendable cash that people are willing to spend goes up. More people are going to race. In the slow times like 2009 and 2010 we saw a dip in the amount of people that were starting up with us. But, you know, the last couple years have been pretty flat as far as revenue. We seem to be getting new customers."
Read the full story at MazdaMotorsports.com
80 shares23hr ago
1.4k shares5d ago
Herta eager to help Wickens get back to racing in IndyCar with hand controls


Red Skinny Jeans with blue blazer! (Today, I got red skinny jeans & white & blue striped blazer. Can't wait to put the look together!
Deep florals + crisp stripes forever & ever.
Done properly you can pull off a red pant at work, at the park or out on the town.
The colour wheel above offers you a visual representation of every shade and, more importantly, the similar, complementary and contrasting colours of each.


text:
Burrito Catering In San Jose
Make your event a memorable experience with delicious burrito catering from local caterers, food trucks, carts, pop-ups, and restaurants.
Toque y Sazón
Toque y Sazon is a food truck that's got a whole lot in the way of authentic Mexican food on board. And if you happen to be in San Jose, CA, it's a really good excuse to hit the pavement, because they've got drool worthy meals that are sure to curb your hunger on the curb. At Toque y Sazon, they're making all your favorites to order for your enjoyment. From tacos and burritos to quesadillas and so much more, each is stuffed with your choice of meat to sink your teeth into. Get classics like carne asada and the sweet and savory al pastor, or try out their exotic meats of the lengua and tripas variety. But that's not all. You'll find a handful of goodness in their torta loaded with milanesa, not to mention their platos especiales. So why wait until hunger comes calling? Beat it to the punch by finding Toque y Sazon in San Jose, or have 'em out to cater your next event. Either way, this is one food truck you don't want to miss. MUST TRY Chorizo Tacos - this spicy Mexican sausage is chopped up and served in warm tortillas, topped with diced onions and cilantro in classic street food form
Preferred Caterer Tacos Burritos Mexican
Weddings Weddings Corporate Catering
Tacos Los 3 Hermanos
Tacos Los 3 Hermanos is well renowned in San Jose, CA, a taco truck that's been servin' up the best for seven years. By serving foodies with all authentic Mexican cuisine on the go, they've earned a loyal following of fans that would follow them to the ends of the earth for their primo food. Or to the end of the block, at least. Just what sets Tacos Los 3 Hermanos apart from the rest? Their commitment to using the freshest quality ingredients around, with traditional preparation methods to add to that fullbodied flavor. From tacos and burritos to quesadillas and enchiladas, get those classics stuffed with meat: Tacos Los 3 Hermanos' got chicken, al pastor, carnitas, cabeza, shrimp and fish to choose from. But that's not all. Tacos Los 3 Hermanos also offers plates full of lamb, along with breakfast eats to get your day started right. Sound good to you? Us too. All the more reason to find 'em cruising in San Jose, or hire 'em to cater your next event. Trust us. It doesn't get better than this. MUST TRY Super Nachos - these nachos are super delicious, featuring a crispy bed of tortilla chips loaded with your choice of meat, refried beans, cheese, pico de gallo, guacamole, jalapenos and a dollop of sour cream on top
Preferred Caterer Tacos Mexican Sandwiches
Food Truck Full Service Caterer Dropoff Catering
Vegans & Vegetarians Corporate Catering Huge Events
Guanatos Tacos
Guanatos Tacos is a Fremont taco truck, taking pride in both its roots in Mexico and the city it now calls home. The food truck serves up a menu full of authentic Mexican cuisine, with twists and turns that cater specifically to California sensibilities. From tacos and burritos to tortas and quesadillas, each is customizable with traditional meats such as carne asada, el pastor and unique beef cuts of lengua and cabeza. But what Cali foodies want is Mexican food anytime of the day, so Guanatos Tacos has an equally delicious breakfast menu with huevos rancheros and chorizo and eggs, to name a few. Oh, and they've got the staples of All American cuisine in burgers, sandwiches and even BBQ pulled pork. Basically what we're saying is, anything you might be craving, you'll find it here. Guanatos Tacos is completely accommodating to its loyal fan following, so join the crowd and find the truck already. It's a surefire way to satisfaction. MUST TRY Carne Asada Fries - a full bed of french fries is topped with savory carne asada and layered with guacamole, sour cream, cheese and salsa
Burritos Mexican Tacos
Tacos El Gordito
Tacos El Gorditio sticks to Mexican classics and knocks them all out of the park. Tacos, tortas, quesadillas and burritos with the flavor you crave are all on the grill, executed beyond your wildest dreams. For an authentic Mexican experience whose border actually comes to you, track down Tacos El Gordito and let your tastebuds do all the talking for you.
Tacos Burritos Sandwiches
Tacomania To Go
San Jose's got not lack of Mexican options, which means whoever's in the game needs to play to win, in order to simply survive. It should say a lot for Tacomania then, that they're not only surviving but thriving, serving up some of California's freshest, tastiest Mexican available on wheels. Street tacos are obviously the first line of attack, prepped authentically and seasoned to perfection. Massively stuffed burritos, loaded nachos, and joyful tortas bring up the next line, ensuring there's something for every taste and every appetite. Special signatures rotate on and off the menu, so giddy-up and catch Tacomania any day of the week for a different experience than the last. Of course, what they'll all have in common is that they'll taste like nothing else in town, a big claim considering the competition, but one that's backed up taco by taco and pepper by pepper. Jump into the game and hit up Tacomania - consider it a cheat code for winning. MUST TRY * Tacos de Barbacoa - Available only on the weekends, these shredded lamb meat tacos bring a mountain of stewed flavor in every bite, til your tongue is positively spoiled against all lesser barbacoa. Try for yourself - a little snobbery never hurt anyone. * Alambre Hawaiano - Pork al pastor diced with pineapples, sautéed onions, bell peppers and melted cheese. It's texture city with no exit, and no equal
Burritos Sandwiches Tacos
Antojitos Estilo De Jaylah's
We don't know who Jaylah is, but whoever she is, she's got great taste. Antojitos Estilo De Jaylah's gives the good people of Mountain View a great reason to get out on the streets: to sample authentic Mexican street food from the window of her food truck. At Jaylah's, what you're getting is time tested recipes, culled from hundreds of years of Mexico City's traditional late night street cuisine. Importing all the heat and spice from south of the border to the northern most part of California is no easy feat, but Jaylah's got a handle on all Mexican eats. And by all, we mean all. From tacos and burritos to quesadillas, sopes, flautas, tortas and nachos, let Jaylah's transport your tastebuds in every savory bite. Find Antojitos Estilo De Jaylah's to fulfill your little cravings in a big way. Trust us. It's well worth the trip. MUST TRY Pambazos - try finding this antojito anywhere else (don't try, you won't find it.) A crustless white bread is dipped into red guajillo chili sauce, filled with potatoes and chorizo and grilled to perfection
Fiesta Mexicana Taco Truck
There's a party going on in Fremont, and by the looks of it, it's one you're gonna wanna be a part of. Or should we say, fiesta. Fiesta Mexicana Taco Truck's got all of the staples of Mexican food, spreading the joy and the heat and the perfectly seasoned meat wherever it goes on the streets. This isn't your average taco truck. Everything on the menu is steeped in tradition, bringing the authentic taste of late night cuisine from the streets of Mexico City right to the heart of California. From tacos and burritos to tortas and quesadillas, let your tastebuds be transported by south of the border bliss. And you can count on Fiesta Mexicana Taco Truck to be there, any time of the day or night, for you to party on down to. So get dancing and tap your toes to that salsa beat. Or put that salsa on your tacos. We'll leave that up to you. MUST TRY Big Super Burrito - it's not just big, it's not just super, it's super big. A beast of a burrito is stuffed with your choice of meat, rice, beans, onions, cilantro and drizzled in sour cream
Tacos Don Cheo
Tacos Don Cheo is giving Fremont a new reason to get out and hit the pavement. Preferably running. You don't wanna miss a chance to get your hands on this taco truck's all authentic Mexican food, from traditional recipes passed down through generations. Just one look at the menu and you'll start drooling. Or maybe it's because of the spicy aroma the truck leaves in its wake. In any case, you're getting tacos, burritos, quesadillas and tortas from the hands of a talented cocinero who's passion for food is only matched by his commitment to using the freshest quality ingredients and traditionally prepared meats. With a menu that's constantly rotating with other Mexican specialties, especially on the weekends when they're serving the savory birria stew, they're guaranteeing repeat visits. Good on you, guys. So track down Tacos Don Cheo in Fremont, San Jose and beyond, and get to eating the best Mexican food the city has to offer. MUST TRY Alambre - it doesn't get much more traditional than this. Grilled beef is topped with crispy chopped bacon, melted cheese, bell peppers and onions, salsa and fresh avocado slices
La Picosita Azteca
La Picosita Azteca is giving Sunnyvale a taste of authentic Mexican food like they've never had before. You might be thinking, sure, there are a whole bunch of taco trucks that probably also have authentic Mexican food. But trust us. La Picosita Azteca is a cut above the rest. From tacos and burritos to tortas and quesadillas, all the staples of traditional Mexican cuisine are here. But La Picosita Azteca ventures into the rarely seen antojitos menu, offering street snacks and classic comforts you'd only find in Mexico City. Until now. Now, it's La Picosita's territory, and they're dominating with pambazos, tostadas de pata and the over the top savory birria de res. And sopes. And huaraches. And honestly too much to list out here. So get on over to La Picosita Azteca to see just what you've been missing. It's bound to be just what you're looking for. MUST TRY Pambazo - we mentioned it before for good reason. Specialty guajillo de chili red sauce coats white bread for a savory sandwich stuffed with your choice of meat
La Chilindrina
La Chilindrina delights residents of Fremont with Mexican specialties. This isn't your average taco truck. Instead, they're importing tradition from the street food scene in Mexico City, offering up antojitos alongside a menu bursting with authentic south of the border flavor. At La Chilindrina, prepare to wait. Them's the breaks, but trust us, it's well worth it. Everything's made to order, using only the freshest quality ingredients including homemade tortillas hand pressed onto a hot grill. If that's not the very definition of fresh, we don't know what is. From tacos and burritos to quesadillas and tortas, you'll find all the staples of Mexican cuisine. But the food truck's got a whole lot more to offer in the way of gorditas, huaraches and the ever elusive pambazo. So track down La Chilindrina and be sure and get there early. As we said, there's always a line and often they'll run out of your favorites. They're just that popular. MUST TRY Pambazo - La Chilindrina's doing it up their way, using green chili verde salsa instead of the traditional red guajillo chili, dipping bread and stuffing it with cheese and your choice of meat
El Sabroson De La Linea 2
El Sabroson De La Linea 2. It's quite a mouthful, but not quite the mouthful you're gonna get when you dig into their full bodied menu of Mexican cuisine. This is a food truck that tackles only the biggest appetites, transporting your tastebuds to south of the border bliss. In Sunnyvale, foodies of every creed line up to sample a collection of all the best in authentic Mexican food, and it's no small feat. They've got 16 different types of tortas. SIXTEEN! All with ingredients inspired from around the world, from Hawaii and Texas to Germany and Russia. And don't get us started on their super burritos, or tacos filled with every traditional meat Mexico has to offer. It's too much to say, and we've already got our mouths full of their delicious food. So find El Sabroson De La Linea 2, and get stuffed. We mean that in the best way of course. MUST TRY Huitlacoche Quesadilla - a big ol' tortilla features melted cheese and the exotic flavor of corn smut. Trust us. Try it. You won't regret it.
Taqueria Patzcuaro
Ask anyone to describe Taqueria Patzcuaro and you'll get the same response: "the food truck with the really long lines." And for good reason. They're serving up authentic Mexican food, prepared from recipes culled from the streets of Mexico City and served on the streets of Sunnyvale, CA. Taqueria Patzcuaro's got all the makings of a fine Mexican restaurant except for, you know, it's a food truck. But the cocineros on board are trained in the art of tortilla making, hand pressing each and every one flat on the grill to form their exquisite tacos, burritos and quesadillas. And we'd be remiss not to mention their full bodied menu of meats, from the classic asada and al pastor to the exotic lengua and tripa. If you visit on the weekend, they've even got menudo, a traditional Mexican stew, and enchiladas just dripping with red sauce. So track down Taqueria Patzcuaro, and get in line. Trust us. It's well worth the wait. MUST TRY Al Pastor Tacos - cut right from the trompo, savory pork is layered with pineapple bits, on freshly pressed tortillas topped with your choice of salsa, diced onions and cilantro
El Torito Azteca
Whoever said not to take the bull by the horns was clearly mistaken. If your problem is the fact that you can't find good Mexican food in San Jose, well, we invite you to do just that. El Torito Azteca is a food truck you're gonna wanna hunt down, grab by the horns, and never let go. Unless it's to stuff your face with their menu full of authentic south of the border flavor. In that case, keep your hands free. From tacos and burritos to tortas and quesadillas, all your favorites are here. But what sets El Torito Azteca apart from the average taco truck is in their extended menu, offering a myriad of specialty items. With three different types of alambre and the all elusive pambazo, you're being treated to the antojitos found exclusively on the streets of Mexico City and imported right to the curb. And don't get us started on their al pastor. So get out there and live your foodie life to the fullest, grab those horns and sink your teeth into the best Mexican food. Trust us. You'd be hard pressed to find this level of quality anywhere else. MUST TRY Al Pastor Tacos - okay, you got us started on it. Juicy marinated pork is cut right from the trompo, topped with diced onions, cilantro, and a chunky slice of pineapple
Los Chapulines
Los Chapulines leaps its way onto the San Jose food truck scene, serving up authentic Mexican cuisine from a taco truck that's totally hoppin'. So that's enough hopper puns, for now. You're getting a full menu of all your favorites here, with quality that's leaps and bounds above the rest. Darn, there we go again. From tacos and burritos to quesadillas and tortas, each is bursting with south of the border flavor, transporting you right to the streets of Mexico without your feet ever leaving the curb. Treat your tastebuds to all the spice and heat they can muster, with a variety of homemade salsas. After that, cool off with a wave of mariscos and tender shrimp. Or keep your feet firmly planted on land with all the traditional meats, from juicy al pastor to the exotic lengua, tripas and cabeza. What we're saying is, you've got options and Los Chapulines delivers on all fronts. So hop to it and find Los Chapulines on the streets of San Jose and beyond. Trust us. You'll be hopping mad if you don't. MUST TRY Camarones Espanizados Torta - the Mexican version of popcorn shrimp, breaded and fried to golden perfection, fills a telera roll stuffed with Oaxacan cheese, lettuce and salsa
Tacos El Pollo Y El Pollito
If you're looking for the best Mexican food in San Jose, look no further than Tacos El Pollo Y El Pollito. This classic chicken duo is serving up a menu full of your favorites that are often described as clucking good. Ok, we'll stop now. From tacos and burritos to quesadillas, if you're craving some Mex-cellent food, you'll find it here. But Tacos El Pollo Y El Pollito takes it up a notch, offering the rarely seen mulitas. Never had 'em? You're in for a treat. Corn tortillas are made crisp on the outside and doughy on the inside oozing with layers of jack cheese and your choice of meats. And they've got a whole lot of 'em, including asada, al pastor, suadero and of course...pollo. So strut your stuff and find Tacos El Pollo Y El Pollito's taco truck on the streets of San Jose and beyond. They're winging in the best from south of the border up to NorCal where it belongs. MUST TRY Chicken Taco - because obviously. Tender bits of chicken are enveloped by hand pressed corn tortillas, topped with diced onions, cilantro, and melted jack cheese
Tacos La Morenita
At Tacos La Morenita, prepare to be treated with the best Mexican food in Saratoga Springs, along with the best customer service. The lovely couple that owns this taco truck pours passion into every authentic dish, along with a whole lot of heat and spice. Prepare to have your tastebuds transported to south of the border bliss. From tacos and burritos to quesadillas and tortas, you'll find all your favorites here. But where Tacos La Morenita shines is in its rarer menu items, including the elusive pupusa and Mexican style hot dog. The couple's committed to tradition, perfecting the art of seasoned meats in the common and exotic variety. Choose asada, al pastor, carnitas, or if you're feeling adventurous, they've got tripas, lengua and cabeza. Really, it's all good. So get out there and find the goodness yourself, San Jose. Tacos La Morenita is there for you, and also available to bring their first rate Mexican cuisine to your next event. Trust us. The food speaks for itself. MUST TRY Pupusa Chicharron - a fat corn tortilla is infused with crispy pork skin and gooey cheese
Tacos Y Burritos El Chicharron
Tacos Y Burritos El Chicharron is a little misleading. Sure, they've got the best chicharrones in the entirety of San Jose, but they're so much more than that. This taco truck's host to a whole bunch of Mexican goodies, stuffed to the brim with authentic south of the border flavor. All the staples of Mexican cuisine are here, from tacos and burritos to quesadillas, tortas and mulitas. But where Tacos Y Burritos El Chicarron shines is in its full roster of traditional meats, featuring carne asada, el pastor and the exotic lengua. And everything's wrapped in handmade corn tortillas, pressed hot on the grill and made to order. Using the freshest quality ingredients, this taco truck's got a handle on delivering good eats to the streets of San Jose. So hit the pavement and find Tacos Y Burritos El Chicharron already. Your tastebuds thank you in advance. MUST TRY Tacos El Chicharron - bits of crispy pork skin sit atop a fresh corn tortilla topped with diced onions and cilantro
Metro Balderas
Metro Balderas is a taco truck with a pedigree. Let us let you in on a little secret. Any time Mexican food is stamped with D.F., you know you're getting the real deal. They're importing tradition from the streets of Distrito Federal, with all the heat and the spice from south of the border, right to the streets of San Jose. From tacos and burritos to tortas and quesadillas, if its Mexican food you're craving, you've come to the right place. Metro Balderas also has a number of antojitos that are a welcome change to your regular old taco truck fare. Take their huaraches, for example. Each starts from a homemade tortilla, hand pressed hot off the grill, and filled with your choice of perfectly seasoned meat. Oh, and topped with cactus. Don't knock it 'til you've tried it. Go ahead, find Metro Balderas and sample all the best in authentic Mexican cuisine. We'd dare you to find better in San Jose, but we already know the answer. MUST TRY Al Pastor Torta - Metro Balderas takes the torta up a notch by stuffing a telera roll with their primo al pastor, topping it with fresh pineapple and Oaxacan cheese
Julie's Food Service And Catering
We don't know who Julie is, but whoever she is, she's got great taste. Especially when it comes to Mexican food. Julie's Food Service And Catering is giving San Jose a taste of late night cuisine, imported from the streets of Mexico City and as authentic as you've ever had it. Julie knows just how to serve up Mexican cuisine, traditionally preparing each dish with recipes passed down through generations. What you're getting is her years of experience, combined with the freshest quality ingredients to compose a menu of all your favorites. And by all, we mean all. Let's list 'em all out, shall we? Tacos, burritos, tortas, quesadillas, sopes, gorditas, enchiladas, platillos...and that doesn't even cover the rest of the menu, featuring Julie's own Mexican hamburger and four varieties of breakfast burrito. What we're saying is, you've got options, and Julie's is there to deliver. So find Julie's Food Service And Catering in San Jose and beyond, or invite her to cater your next event. It's in the namesake, after all. MUST TRY Nopales Breakfast Burrito - Julie's specialty features a warm handmade tortilla wrapping freshly cut cactus alongside scrambled eggs and melted cheese
Mi Rancherita
Mi Rancherita isn't here to reinvent the classic taco truck model, it's here to perfect it. And San Jose's lucky to have 'em. They're bringing up the classics of Mexican cuisine, importing south of the border flavor in every savory dish. Get ready to treat your tastebuds to a level of heat previously unknown. Mi Rancherita's outfitted with a bevy of homemade salsas, from the mild salsa verde to the hottest orange that's bound to set your mouth on fire. Or choose not to. Honestly, the traditional meats are so perfectly seasoned that you don't need 'em. From carne asada to al pastor and lengua and cabeza, choose a meat and choose your form. They've got tacos, burritos, quesadillas and empanadas to satisfy even the biggest appetites. So get out and hit the pavement, you'll find Mi Rancherita's got just what you're looking for in a taco truck, and so much more. MUST TRY Chile Verde Tacos - handmade tortillas envelop pork in a green chili sauce, topped with diced onions and cilantro
Burrito Food Truck Catering For Any Event In San Jose
Tell us when & where you want Burrito catering.
We'll send you a list of available Burrito caterers.
Explore Other Catering Types In San Jose
Somalian


It has been known in the rumor universe that the US-based online retail giant Amazon is currently working on its first smartphone offering which is reported to be unveiled in a couple of months from today. And to add a little more reality to that speculations and unconfirmed reports, BGR managed to get and leak a photo (above) of the supposed first Amazon smartphone.
Unfortunately, the device is not photographed in ita full physical design as it is enclosed in a protective shell which according to the report is meant to be so unauthorized people will be prevented from accessing or looking or leaking the photo of the actual design of the smartphone. I thought it was the design of the Amazon-branded phone but thank goodness it's covered.
The device does not have a project name or a temporary name right at this point unlike Nokia's first Android phone the Nokia X which was referred to as "Normandy" during its development and rumor days. To me, this looks like a very slim smartphone and the screen is kind of interesting to see it more and check what this gadget has in store for us.
According to the reports, this smartphone will measure around 4.7 inches in its screen and will feature an HD display or 720p resolution. I hope that is not true as the current standard for smartphones and tablets today is 1080p or full HD display. Of course just like any other Amazon tablet like the Kindle Fires, this smartphone here will run a heavily customized Android software.
One of its main selling points is its glassess-free 3D software interface. Part of this technology, according to rumors is the four low-power cameras situated in four corners of the phone's front panel and that's on top of the standard rear and front facing cameras. So we are talking about 6 cameras here overall. These four cameras here will work as sensors to the device, these will detect the position of the user's face and eyes from the screen of the phone so that the display will adjust to the angle of he user's face to continue deliver its 3D features.
If these 3D thing and its cameras functions are true then this is going to be an interesting phone and if performance and pricing are also promising then I think this will also make its own name in a very crowded smartphone market, just like what the first Kindle Fire did when it debuted in the US.


ulao wrote: what's funny about that is I had that same misunderstanding.
Though I completely over looked that.
So... you're saying that I can use an Atmega168 and I should not have any issue like i'm having right now? I'll give it a try, since my PCB is already setup at my PCB fab. I would save some $$$.
Maybe there are 1 or 2 caps missing.
Thanks vouvoume for clarifying that.
Do you know any issues or particularities with atmega328p bootloader versus atmega8 ?
This is something wrong. According to the documentation, for a 328p it should be direct jump with "jmp 0x????" and not an indirect rjump. Do you know how to change that?


text:
Q: Trouble mapping YAML to Java Object I am new to Yaml, and not sure exactly how to map this simple Yaml to a Java Object. Basically, the serialization is all done, I just need a Java object that models the Yaml.
This is my Yaml:
thriftResources:
  - class: MissionWork
    jsonIdField: id
    jsonResource: test
  - class: MissionResource
    jsonIdField: uuid
    jsonResource: test2

So far, I have this as my class:
@Valid
public ThriftResourceConfiguration thriftResources = new ThriftResourceConfiguration();

public class ThriftResourceConfiguration{
    @NotNull
    @JsonProperty
    ????
}

What I am looking for is what the Java object should look like in order to map correctly.

A: YamlBeans can be used to serialize and deserialize Java object graphs to and from YAML.
http://yamlbeans.sourceforge.net/
YamlReader reader = new YamlReader(new FileReader("contact.yml"));
Object object = reader.read();
System.out.println(object);
Map map = (Map)object;
System.out.println(map.get("address"));


Spoiler alert: I got a standing desk. Let's see how it all went down.
The day I arrived back at the office after our vacation, something else arrived at the office as well – my new desk. Standing at work gets lots of press, including a recent article I linked to about how sitting all day can be worse than smoking. In an effort to incorporate more overall wellness into my life, including my life at work, I asked my supervisor if he thought the company would be open to purchasing a standing desk for me to use. When he thought it sounded like a great idea, I began my research in earnest.
An idealized, slightly hipper version of me at my at my potential future desk, courtesy of Wired Magazine.* Illustration by Joel Kimmel.
Our office has a very contemporary, stylish aesthetic. All the desks are a dark wood veneer, with square raw steel legs. A very Room & Board vibe (except ours were custom built and much more affordable; I have a R&B Parsons desk at home, but I couldn't imagine shelling out for an entire office of them). Unfortunately, most adjustable desk options on the market interpret "modern" in a very different way. My desktop options seemed to be birch or black – no rich brown with a beautiful grain – and my base options weren't much better. There are beautiful contemporary options out there (including one from Room & Board), but their $2000+ price tags were less palatable than their more desirable aesthetic.
Another category of options that I found but ruled out were the "desk attachment" models like the Kangaroo Pro. Instead of replacing my current desk, these options would attach to or rest on top of my desk and move my computer workstation up and down as needed. While popular (the Kangaroo Pro and other products from Ergo Desktop get especially great reviews), there were two big drawbacks for me. One was how they look – the aesthetics seem more suited to a hospital or corporate environment than the progressive, predominantly digital creative agency I work for. The other was the amount of workspace. If I type all day, having something that just moved my monitor, keyboard and mouse up and down would make sense. But I also take old-school notes in my notebook, access file folders, use multiple monitors, test things on multiple mobile devices at once… having multiple levels of desktop to move between didn't seem like it would meet my needs.
Enter GeekDesk. Among the nerdy circle I travel in, they're probably the most common standing desk option. Unfortunately, you don't get a lot of style options; birch or black for the top, silver or black for the base. I didn't want to be "that girl" with the desk that didn't match anyone else's. But, while browsing around, I discovered the One Desk Option to Rule Them All: The GeekDesk Frame. I could remove the legs from my nice desktop and attach it to the GeekDesk frame, so at a glance it would still match the rest of the office. It would just happen to move up and down. I went with the cheaper "v3" desk frame option vs. the "Max" option since I didn't need programmable desk positions, and my boss placed the order for a black frame (the silver would definitely have stood out). Easy peasy.
I made the mistake of wearing a dress to work the day I assembled the desk (see above). It was awkward, but I managed to put everything together without any "inappropriate conduct" complaints from my coworkers because they'd been subjected to an unexpected glimpse of my underpants. The desk with motorized legs is much heavier than the desk with static legs, so four of my gentleman coworkers helped me move it into place. And voila! Standing desk! Everyone who visits the office has been treated to a demonstration of the desk's motor (truly a show-stopper for old-school fixed-desk folk), and I think several other coworkers are contemplating asking for a standing desk of their very own. Which means – I'm saving lives, people.
*Thanks for the image, Wired.


A few EMD products idle in the Lawrence yard on a beautiful Memorial Day weekend. Note: taken from a parking lot adjacent to the yard. Luckily for me the fence was partially flattened, presumably damaged from winter plowing.


Rob Lowe is going to send a Zinger into space.
The actor will be the newest version of KFC's Colonel Sanders in ads featuring the Zinger sandwich.
In the ads, the veteran actor and funnyman will wear a spacesuit, talking about sending KFC's Zinger out into space. The ads are set to start on Sunday.
KFC has used a series of advertisements featuring various actors and comedians playing its iconic founder over the past two years. The irreverent ads have helped reinvigorate sales at the Louisville-based chicken chain. Several actors have taken turns playing Sanders.
The latest ads come as the chain has introduced its Zinger to the U.S. The sandwich is popular in KFCs around the world, and the chain is finally bringing it stateside next week. It's served with lettuce and mayonnaise on a toasted sesame seed bun.
First introduced in Trinidad & Tobago in 1984, the sandwich is marinated chicken breast, double-breaded in the chain's Extra Crispy breading with a proprietary spice blend.
It will be available as part of KFC's line of $5 Fill Up boxes, along with potato wedges, a cookie and a drink. An individual sandwich will be priced at $3.99.
KFC is promising more details about its campaign to send one of these sandwiches into space later this spring.


Abstract The global financial crisis clearly started with problems in the U.S. subprime sector and spread across the world from there. But was the direct exposure of foreigners to the U.S. financial system a key driver of the crisis, or did other factors account for its rapid contagion across the world? To answer this question, we assessed whether countries that held large amounts of U.S. mortgage-backed securities (MBS) and were highly dependent on dollar funding experienced a greater degree of financial distress during the crisis. We found little evidence of such direct contagion from the United States to abroad. Although CDS spreads generally rose higher and bank stocks generally fell lower in countries with more exposure to U.S. MBS and greater dollar funding needs, these correlations were not robust, and they fail to explain the lion's share of the deterioration in asset prices that took place during the crisis. Accordingly, channels of indirect contagion may have played a more important role in the global spread of the crisis: a generalized run on global financial institutions, given the opacity of their balance sheets; excessive dependence on short-term funding; vicious cycles of mark-to-market losses driving fire sales of MBS; the realization that financial firms around the world were pursuing similar (flawed) business models; and global swings in risk aversion. The U.S. subprime crisis, rather than being a fundamental driver of the global crisis, may have been merely a trigger for a global bank run and for disillusionment with a risky business model that already had spread around the world.