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In 2021, psychedelic medicines moved from the frontiers of scientific research to the front pages of newspapers worldwide.
This was driven by a growing body of research and the results of groundbreaking clinical trials. Studies have demonstrated the potential for psychedelic medicines to treat a wide range of illnesses, where currently available treatments have proven ineffective, which has garnered the support of healthcare providers, patients and the public.
The Psychedelics as Medicine Report: Third Edition revealed two-thirds of Europeans and North Americans support the legalisation of psychedelic-assisted therapy, with jurisdictions enacting legislation to facilitate its adoption. Six states in the United States have decriminalised psychedelic medicines, with 20 loosening regulations to support research into their efficacy.
The tipping point
Dozens of drug development companies are sponsoring clinical trials with psychedelic medicines, many of which are publicly listed. As investment in psychedelic companies has surpassed US$2 billion, resources that can be invested in the research and development of psychedelic-assisted therapies have skyrocketed.
This has created an environment conducive to the accumulation of clinical evidence on the efficacy of psychedelic medicines at an unprecedented rate. Over 300 clinical trials have been conducted since the turn of the century, with over 50 currently taking place, and psychedelic research centres have opened at Imperial College London, Harvard University and Massachusetts General Hospital. The majority of the trials are still in Phase I, which explores the treatment's safety, before moving on to investigate efficacy in phases II and III.
The only psychedelic treatment currently in Phase III clinical trials is MAPS' MDMA-assisted therapy for PTSD, with FDA approval expected in 2023. Earlier this month, COMPASS Pathways released data from its Phase II study to combat treatment-resistant depression, which, although impressive, saw the company's share price fall 22%.
This presented a lucrative opportunity for savvy investors to support a well-funded company at the forefront of psychedelic research. atai Life Sciences, the largest publicly traded psychedelics company with underwriters including CitiGroup, Berenberg and RBC Capital Markets, is COMPASS's largest shareholder and increased its ownership stake in the company from 19.4% to 20.8%, for US$12 million.
Regulatory approval
To support the escalating number of clinical trials, the DEA has bolstered its proposed production quotas for psychedelic medicines – particularly MDMA, psilocybin, DMT and LSD.
The federal agency announced that the quotas for MDMA and DMT production will be increased from 50 grams each in 2021 to 3,200 grams in 2022. Substantial increases in other compounds have also been mooted, with the LSD quota raised from 40 grams in 2021 to 500 grams next year.
This indicates government support for psychedelic medicines and their development, with decriminalisation campaigns sweeping the US. Last year, Oregon became the first state to decriminalise personal possession of all drugs. Washington, Colorado and New Jersey have also enacted reduced penalty legislation for possession of naturally occurring psychedelics, with California expected to go to the polls in 2022.
The majority of North Americans and Europeans now support the regulation of psychedelic-assisted therapy, in a significant shift that could expedite its adoption. In the UK, a recent YouGov survey found overwhelming support for the rescheduling of psilocybin for research purposes, with MP Crispin Blunt championing the campaign alongside the Conservative Drug Policy Reform Group.
Patient and practitioner support
The excitement around the promise of psychedelic medicines has been echoed by health providers, practitioners and their patients. The Psychedelics as Medicine Report found over two-thirds of medical professionals support easing restrictions that hinder research, with 60% hoping to provide psychedelic-assisted therapy in the future.
Patients, for many of whom current treatments don't work, strongly support the availability and accessibility of psychedelic medicines – if proven to be safe and effective. The compounds consumers are most willing to try include MDMA, psilocybin and LSD, with knowledge of their efficacy in clinical trials on the rise.
With a burgeoning number of clinical trials expected to take place in 2022 and 2023, supported by increased investment and revised regulations, the psychedelic healthcare industry is expected to exceed US$2.4 billion by 2026. Following their regulatory approval in 2023 and 2024 respectively, MDMA and psilocybin-assisted therapies are expected to account for the largest share of the emerging market.
For further investor intelligence on the psychedelic science and healthcare industry, download The Psychedelics as Medicine Report: Third Edition, powered by Blossom.


Memphis Tigers coach Tubby Smith says rise in transfers is teaching players "how to quit."
Tubby Smith ranted about the rising number of transfers in college basketball on Sunday. He thinks it's teaching players "how to quit."
Memphis coach Tubby Smith bemoaned the rising number of transfers occurring in college basketball in a rant that drew national attention following Sunday's win over ECU inthe regular season finale.
Memphis was hit particularly hard by transfers after Smith's first year on the job. Six players sought a transfer after the 2016-17 season, including the team's top three scorers. Five landed at other Division-I schools.
Smith's head coaching career includes stops at six different schools, including stints at Tulsa (1991-95), Georgia (1995-97) and Texas Tech (2013-16) that lasted four years or less.
On Sunday, Smith repeated a story he used previously about when he played at High Point College in 1969 and called his father to express a desire to transfer.
"Best thing he ever said to me," Tubby Smith said on Sunday.
Smith noted that he would talk to the players on this year's Memphis roster once the season ends, but that he couldn't control the numerous voices influencing their decisions these days.


The Spencer carbine was a mechanically-complex arm whose manufacture was beyond the capability of Southern industry. These guns were used with great effectiveness by Northern troops.
In 1864, General Sherman captured Atlanta and then began a terrible march through Georgia to the Atlantic. Next, Grant supplied General Phil Sheridan with 10,000 mounted men equipped with Spencer seven-shot carbines, the prototype of which had been personally approved by President Abraham Lincoln. These events ended all hope of a Southern victory.
The Spencer rifle, with its lever action, seven shot tubular magazine and internally-primed metallic-cased cartridge, was a popular wartime breechloader. Its inventor, Christopher Spencer, was a native of Connecticut and a former employee of Samuel Colt. His design was one of the most technologically-advanced arms of the Civil War era, but because of the time required to sell both his idea and his guns to the U.S. government, they were not available until 1863.
These modern arms, in both rifle and carbine configuration, were more than a match for anything that the Confederates could muster. The firepower of the Spencer was used with devastating effect on many Civil War battlefields. In its first combat test, Spencer-armed Union troops under the command of Colonel John Wilder earned the nickname "Lightning Brigade" when they defeated a numerically-superior Confederate force at the Battle of Hoover's Gap, Tennessee on June 24, 1863.
One week later, the Spencer again saw action in the hands of troopers of the 5th Michigan Cavalry Regiment of George Custer's Brigade at the Battle of Gettysburg. Spencers continued to serve through the end of the Civil War, and saw action during the Indian Wars as well.
Christian Minor Spencer was born in Manchester, Connecticut on June 20, 1833. At age 11, he went to live with his maternal grandfather, Josiah Hollister, a veteran of the Revolutionary War. It was there that young Christian learned the rudiments of wood- and metalworking. By the age of 14, Spencer was apprenticed to the Mount Nebo Silk Manufacturing Co., located in South Manchester, Connecticut. This firm was owned by the Cheney family, one of New England's most enterprising and influential families. After a year, he entered a second apprenticeship, this time with local machinist Samuel Loomis.
In late 1850, Spencer returned to the employ of the Cheneys as a machinist. During this period, he perfected several experimental machine designs, and in the process, he developed what would be a lifelong relationship with the Cheneys. At the advice of Frank Cheney, Spencer worked as a toolmaker in Rochester, New York, then as a machinist in the locomotive repair shops of the New York Central Railroad. He also worked briefly for the N. P. Ames Company of Chicopee Falls, Massachusetts, where he received his first formal experience with the manufacture of firearms. His next stop was at the factory of Samuel Colt, where he helped to design many of the specialized machines used in the production of Colt revolvers.
Christian renewed his employment with the Cheney family in 1854 when, at the age of 22, he became superintendent of his benefactor's new silk ribbon manufactory in Hartford. During this period, Spencer designed and patented a machine to attach labels to spools, thus allowing one shop girl to do the work of three. The Cheneys paid Spencer a $25 royalty on every machine he produced. Although working 11 hour days six days per week, Spencer began to experiment with an idea for a breech-loading repeating firearm.
By 1859, with the encouragement of both his father and the Cheneys, he had perfected a lever-action rolling block rifle design, and on March 6, 1860, he was awarded a U.S. patent for his work. With financial backing from his father, Ogden Spencer, a prosperous wool merchant, Christian was able to secure the services of Luke Wheelock, an experienced gunsmith, for the production of prototype firearms. Spencer also befriended Richard S. Lawrence, then superintendent of the Sharps Rifle Manufacturing Company, and this association most likely influenced certain aspects of Spencer's design.
By the spring of 1861, civil war had come to America, and the Cheney family entered into a contract with Spencer in which all rights and patents for Spencer's rifle design would be assigned to them. In return, Spencer would receive a royalty of $1 for every rifle produced. This was later lowered to 50 cents for each military arm produced. The Cheneys had long been friends of Gideon Welles, Secretary of the Navy in Abraham Lincoln's administration, and this gave them, and Spencer's rifle, access to government officials in Washington. At this time, Spencer also contracted with Connecticut ammunition makers Crittenden & Tibbals for the manufacture of a .56 caliber rimfire metallic cartridge for use in his rifle.
In its final form, the Spencer rifle employed a spring-loaded seven-shot tubular magazine which was located in the buttstock, and a lever-action which, when operated, ejected a spent cartridge and chambered a fresh one. Manual cocking of the hammer then readied the rifle for firing. The stage was now set for Spencer's rise to fame. Through the patronage of Secretary Welles, Spencer's rifle was successfully tested by the Navy, resulting in the purchase of 1,000 guns. Army trials followed in the spring of 1862, and this resulted in the sale of an additional 10,000 guns. In addition, President Abraham Lincoln also took part in a demonstration of the Spencer, firing seven shots at a target forty yards away. This demonstration took place on the Mall, near the site of the Washington Monument, and resulted in Lincoln's personal endorsement of the arm.
Spencer now had contracts but no manufacturing facilities. Once again, the Cheney family would prove to be indispensable to Spencer, as Charles Cheney rented a portion of a piano factory in Boston for production of Spencer firearms. After several delays, the first shipment of Spencer carbines was delivered on December 31, 1862. Both Army and Navy placed additional orders during the summer of 1863, and many other Spencer arms were purchased privately.
By the end of the war, more than 144,000 Spencer rifles and carbines had been manufactured; over two-thirds were purchased by the U.S. government. To keep up with demand, Spencer subcontracted some production to the Burnside Rifle Co. of Providence, Rhode Island. Spencer rifles and carbines met with high praise from those who were equipped with them, and with respect from those who faced them in battle. In its first combat test, Spencer-armed Union troops under the command of Colonel John Wilder earned the nickname "Lightning Brigade" when they defeated a numerically superior Confederate force at the Battle of Hoover's Gap, Tennessee on June 24, 1863. One week later, Spencer rifles again saw action in the hands of troopers of the 5th Michigan Cavalry Regiment of General George Armstrong Custer's Brigade at the Battle of Gettysburg.
Wilder's troops were called on again at the Battle of Chickamauga in September, 1863, when they fought to hold the Union center in the face of determined attacks by General James Longstreet's Confederates. Spencer rifles and carbines also saw service with several other Union infantry and cavalry regiments. Although the South lacked the capacity to manufacture metallic cartridges used by the Spencer, captured arms and ammunition saw service with troops under the command of Colonel John Mosby, the famed "Gray Ghost of the Confederacy," as well as with other units and individuals.
The effectiveness of the Spencer was greatly increased by two other inventions, the Blakeslee cartridge box, and the Stabler cut-off device. The Blakeslee cartridge box was invented by Union cavalryman Erastus Blakeslee and consisted of a leather-covered wood box containing six to ten tubes, each of which held seven Spencer cartridges. Troops equipped with these boxes could quickly reload the gun that, in the words of one awed Confederate, could be "loaded on Sunday and fired all week."
Later Spencers, beginning with the Model 1865, were equipped with a cut-off mechanism invented by Edward Stabler which, when engaged, prevented the breechblock from moving far enough to chamber a cartridge from the buttstock magazine. This device permitted the Spencer to be used as a single-shot arm, with a full magazine held in reserve.
Spencer carbines continued to serve on the frontier after the Civil War, but the firm's prodigious wartime output contributed to a large post-war surplus. Declining sales forced the Spencer Repeating Rifle Co. into insolvency, and in October, 1868, all of the company's assets were sold to the Fogerty Rifle Co. of Boston. Within a year, Fogerty's assets were in turn purchased by Oliver Winchester, and Christian Spencer agreed to assign all future repeating rifle designs or improvements to Winchester.
Spencer later returned to the firearms industry with the formation of the Spencer Arms Co., which manufactured his design for the first practical pump-action shotgun. This firm was later sold to noted arms dealer Francis Bannerman. Christian Spencer died on January 14, 1922.


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Eden II Students Dancing Through The Decades
Eden II Students Dancing Through…
Eden II School Program Dance Recital
STATEN ISLAND, NY—Eden II Programs, a not-for-profit agency serving children and adults with autism, choreographed a dance recital on Tuesday, November 19thatTrinity Lutheran Church in Stapleton. Thirty students from Eden II's School Program performed and the presentation was directed by Eden II's Dance Instructor, Mr. Kelly Gilmore. The theme was Dancing through the Decades.
Eden II's Executive Director, Dr. Joanne Gerenser shared, "Thank you to Mr. Gilmore; his presentation of Dancing through the Decades was performed before members of Eden II and their family and friends. The the show was a big success. The students performed well and had a great time. The parents were very happy to see their kids having a good time singing and dancing."
The show began in the 1920's with a Fox Trot and Charleston. The program then ran through various decades and styles, including swing dancing, the Electric Slide, and freestyle dance.
Mr. Gilmore is owner and director of Dance Staten Island in Arrochar, and has been teaching dance to students at Eden II for over two years. This year, his efforts were rewarded with a Premier Art Fund Grant provided by the New York City Department of Cultural Affairs. DCA Grants support both individual Staten Island artists and community arts and cultural organizations in presenting art and cultural programming through projects and public presentations.
Mr. Gilmore stated, "This funding made a huge impact on our program by giving our dancers the chance to attend class twice a week throughout the year. As a teaching artist, I am committed to the continuation and growth of our dance program here at Eden II, and to offering more opportunities for these young performers to express themselves through music and dance."
The grant is funded through the Greater New York Arts Development Fund (GNYADF) of New York City's Department of Cultural Affairs (DCA). The grant program is administered locally by Staten Island Arts.
Mr. Gilmore continued, "The project not only builds upon the students dancing skills, it has also helped them in fulling their potential with regards to communication and social interaction. As their teacher, I am so proud of the accomplishments of our dancers."
About Eden II Programs
Established in 1976, Eden II Programs began with just six students and one special education teacher. Today, the organization serves over 500 participants throughout the five boroughs and Long Island. The mission of Eden II Programs is to support people with autism throughout their lives to achieve their full potential through service, science, and passion. Eden II Programs provides a variety of services using the evidence-based principles of applied behavior analysis (ABA) to treat the specialized learning needs of individuals with autism spectrum disorders.
Currently, 170 individuals and families use Eden II's full-day school program, preschool, special education teacher support services and special education itinerant teacher services in Staten Island. The adult day habilitation programs serve more than 100 individuals. Fifty-one adults with autism reside in seven adult homes located on Staten Island and Long Island. The Genesis School program and adult day program assist a total of 73 participants throughout Long Island. Hundreds benefit from a variety of other services, such as clinical assessments, community habilitation, respite, after-school and a variety of other specialized programs and family supports. To learn more visit eden2.org.
Interview with Randy Horowitz
March 4th: Five Borough Virtual Legislative Breakfast
From Spectrum News NY1: Special needs schools struggling to retain staff amid funding disparities want Hochul's help
Hochul could reduce 'outright discrimination' against special needs kids with the stroke of a pen, says head of Eden II
Eden II School
Eden II is a proud recipient of DYCD funding and support

redpajama_set_name: RedPajamaCommonCrawl


Devon M. Largio is a litigation partner in Kirkland's Chicago office. Her practice focuses on complex commercial litigation, including breach of contract, fraud and fiduciary duty claims, securities, accounting malpractice, and antitrust matters. Devon also has experience in non-competition and ERISA matters. Throughout her career, she has represented a variety of clients across numerous industries, including Honeywell, PwC, Ally Financial, Aon, Health Care Service Corporation, and BP, among others. She also advises and counsels private equity and corporate clients on non-competition and other litigation matters.
Counsel for Honeywell in trade secret misappropriation dispute with former employee.
Counsel for PricewaterhouseCoopers LLP in Bettina M. Whyte v. PricewaterhouseCoopers LLP, a multibillion dollar accounting malpractice action asserted by litigation trustee arising from the failure of the country's largest private midstream oil and gas company, SemGroup, L.P. (a former PwC audit client). Also represented PwC in Madoff-related litigation, and in the Morgan Keegan Funds litigation, including SEC investigation and civil securities claims arising from significant losses in mutual funds invested in CDOs.
Counsel for Ally Securities in FHFA v. Ally Financial, et al., a billion-dollar securities litigation brought by the Federal Housing Finance Agency related to the sale of MBS.
Counsel for Health Care Service Corporation in various ERISA putative class actions.
Counsel for Aon in suit alleging antitrust claims related to receipt of contingent commissions.
Counsel for Exxon in putative dealer class action alleging breach of contract and unfair trade practices claims.
Counsel for former corporate executives in securities fraud class action arising from the Conseco, Inc. bankruptcy.
Counsel for BP in In re Direct and Indirect Purchaser Antitrust Litigation, putative class actions consolidated in the Northern District of Illinois concerning allegations of propane trading manipulation, and related opt-out litigation.
Counsel for R.J. Reynolds in the 2003 NPM Adjustment Proceedings, a nationwide arbitration involving forty-six states and arising from dispute over 1998 Master Settlement Agreement between states and major tobacco companies.
Litigation risk assessment and counsel for private equity and corporate clients.
Represented pro bono clients in immigration and probate proceedings at the trial and appellate court level.
Devon Largio, Teen Dating Violence and Domestic Violence Statutes: Refining the Meaning and Application of "Dating Relationship," 60 Vand. L. Rev. 939 (Apr. 2007).
Scott Althaus & Devon Largio, When Osama Became Saddam: Origins and Consequences of the Change in America's Public Enemy #1, 37 PS: Pol. Sci. & Pol. 795 (2004), reprinted in Quantitative Methods in Practice: Readings from PS (David Rochefort ed., Congressional Quarterly 2005).
Devon Largio, 21 Rationales for War, Foreign Pol'y, Sept.-Oct. 2004, at 18.


Ariela Morgenstern is an educator, business coach, and actor. She is a certified executive coach with the Berkeley Executive Coaching Institute at the Haas School of Business, and has a presentation coaching practice in San Francisco.
She teaches Leadership Communications at the Haas School of Business, as well as improv for MBA students at UC Davis, and Storytelling for Leadership with Arina Isaacson and BECI for companies all around the Bay Area.
Ariela is also an award-winning singer and has spent the last nine years in the professional theatre world in New York, performing in musicals in the city and across the country. She has sung as the soloist for Imant Raminsh's Symphony of Psalms at Carnegie Hall, and was most recently seen in the new musical The Names We Gave Him at The Public Theatre, and playing Diana in Next To Normal at Baltimore Center Stage.
She holds a Bachelor of Music in Opera Performance and Theatre from U.C. Santa Cruz, and is passionate about using vocal technique and the tools of the actor as a bridge to the business world to enable anyone to be more authentically present and vibrant.
"Ariela is one of those memorable teachers whose powerful balance of spontaneous humor and knowledge-driven focus makes for a hugely enjoyable and highly personal learning experience. Her voice and body awareness workshop is an eye-opening plethora of new perspectives, tools and exercises in physical and vocal exploration.


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Limp Bizkit have announced the 2022 U.S. STILL SUCKS tour. The band will be supported by Scowl, WARGASM, $not, Dying Wish and Yung Gravy on select dates.
The tour is in support of the band's latest album, the 2021 release STILL SUCKS.
Read more: 20 nü-metal bands that defined the late '90s and early 2000s
Limp Bizkit was originally planning on touring for the album last year, but they were forced to bow out due to COVID-19 related concerns.
The AEG Presents trek kicks off in the band's home state of Florida April 28, hitting venues across the United States (including Madison Square Garden in New York City May 13) before concluding in California on May 18.
To announce the tour, Limp Bizkit shared a playful video. You can watch it below.
https://media.altpress.com/uploads/2022/03/Limp-Bizkit-SP92951-30-16×9-AV.mp4
Tickets for the tour go on sale March 18 at 10 a.m. local time here. Check out a full list of dates below.
Limp Bizkit Still Sucks tour dates
04/28 – Tampa, FL @ Hard Rock Live* ++
04/30 – Hollywood, FL @ Hard Rock Live* ++
05/03 – Norfolk, VA @ Chartway Arena*
05/04 – Roanoke, VA @ Berglund Center*
05/06 – Atlantic City, NJ @ Hard Rock Casino* ++
05/07 – Wilkes-Barre, PA @ Mohegan Sun Arena at Casey Plaza*
05/10 – Lowell, MA @ Tsongas Center*
05/12 – Uncasville, CT @ Mohegan Sun Arena* ++
05/13 – New York, NY @ Madison Square Garden*
05/15 – Baltimore, MD @ Chesapeake Employers Insurance Arena*
05/18 – Youngstown, OH @ Covelli Centre^
05/19 – Saginaw, MI @ The Dow Event Center^
05/21 – Gary, IN @ Hard Rock Casino^ ++
05/22 – Green Bay, WI @ Resch Center^
05/24 – Kansas City, MO @ Cable Dahmer Arena^
05/26 – Loveland, CO @ Budweiser Events Center^
05/28 – Las Vegas, NV @ The Theater at Virgin Hotels Las Vegas#
05/29 – Reno, NV @ Reno Events Center#
05/31 – Ontario, CA @ Toyota Arena#
*with $not, WARGASM and Scowl
^with Yung Gravy, Dying Wish and WARGASM
#with Dying Wish and WARGASM
++ Non-AEG show
The post Limp Bizkit announce 'STILL SUCKS' tour dates for 2022 appeared first on Alternative Press Magazine.


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Q: wysiwyg or rich text in kivy python so i'm new to kivy and i have kachground from the web dev, and i have to create a rich text.
so i want any idées or solutions or librarys or steps on how to do that in kivy.
my probleme is that i don't know how to select a texte and make changes on it(change his size or it's color ...etc).
as a final result i want somthing like this

redpajama_set_name: RedPajamaStackExchange


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Home Obituaries Molly Chernofsky
Molly Chernofsky
Justin Hopper
Longtime Roslyn resident Molly Chernofsky, age 67, passed away on Nov. 16, after a brief illness. Born in Germany in 1947, Molly immigrated to this country with her parents as a young child and spent her early childhood on Manhattan's Lower East Side. She became a teacher and taught English at Bryant High School in Long Island City for 37 years, retiring in 2006. She was a devoted wife to Irving, the loving mother of daughter Sheryl Saltiel and her husband Joseph, and of daughter Melissa Chernofsky, and the adoring grandmother of the Saltiels' three children: Matilda, Johanna and Harrison. She is also survived by her cherished brother, Sam Mora.
Molly was active in Women's League for Conservative Judaism and, at the time of her death, was an officer on the international board. She was a role model for many women in the community, serving as president of the Sisterhood at Temple Beth Sholom in Roslyn Heights for two terms totaling four years, and then moving on to the presidency of the Brooklyn – Queens – Long Island (BQLI) Region of Women's League.
A strong believer in women's empowerment, Molly encouraged many of her "sisters" to become leaders. She greeted everyone warmly and with a friendly smile. She was also a passionate advocate for Israel, and headed up the temple's delegation to the American Israel Public Affairs (AIPAC) Conference in Washington, D.C., in 2014. Her passing is a great loss to our community, as everyone who knew Molly respected and loved her. She inspired so many people. The Sisterhood of Temple Beth Sholom extends its deepest condolences to Irving and the Chernofsky family.
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Oh no! This Osprey Cam is down with technical issues. Please check out our four other cams in the meantime.
Welcome to Audubon Connecticut's Live Osprey Cam! This live video provides a unique, genuine, and close-up view of Osprey, a migratory bird that breeds in Connecticut in the spring and summer. During the breeding season, you will have a chance to observe nature in action through the daily lives of the Osprey occupying this platform as they build their nest, feed, incubate their eggs, and care for their young.
Thank you for visiting! Stay tuned to see what happens next! You might even see other birds or interesting natural occurrences during other times of the year!
Please note, this camera is powered by solar energy. Expect streaming interruptions during low-light conditions, overcast, and unfavorable weather—when the camera has not received enough sunlight to power up.
You may have noticed there is trash in the nest. Unfortunately, Ospreys collect trash for use in nesting and it is unclear why. This serves as a good reminder for us humans—please remember to properly dispose of trash and to reduce, reuse, and recycle!
The installation of this camera was made possible by a generous anonymous donor. Additional in-kind assistance was provided by the Riverside Yacht Club and Atlantic Marine Construction, along with the Menunkatuck Audubon Society and Audubon volunteers. Thank you to everyone involved for bringing this camera to life—for all to enjoy!
To view Osprey cam video highlights, visit us on YouTube.
Select here to view our cam/nest intervention protocol.
View more wildlife cams on Audubon Live!
We need your ongoing support to continue making a difference for birds, other wildlife, and people of Connecticut! Your gift to Audubon Connecticut helps to connect people with nature, preserve habitat, and protect bird species that are of state, national, and global concern. Please Donate Today!
Through our Cardinal Club Monthly Giving Program, you can provide critical support for our conservation work. Your reliable gift will ensure we have the resources to protect nature in Connecticut.


MINNEAPOLIS (May 10, 2018) – Polaris Slingshot, the open air, three-wheeled roadster that delivers "The Ultimate Joyride™," today announced Club Slingshot, a national owners group that is designed to embrace a strong, growing community and recognize the loyal Slingshot owners across the country. In its inaugural year, more than 25,000 new and used Slingshot owners will receive a complimentary one-year membership, which includes special offers, access to events and rides, as well as a first-edition Slingshot owners magazine.
Join the club and help shape the membership experience for years to come. For more information aboutClub Slingshot, visit ClubSlingshot.com. Follow Slingshot on social media: Facebook.com/PolarisSlingshot,@Slingshot on Twitter and @PolarisSlingshot on Instagram. For information on Polaris Adventures and Slingshot rental locations, visit Adventures.Polaris.com.
Polaris Slingshot®, a product of Polaris Industries Inc. (NYSE: PII), is a three-wheeled motorcycle that delivers a ride like nothing else you've ever experienced. It is "The Ultimate Joyride™." The Slingshot is powered by a 2.4-liter engine with a five-speed manual transmission and comes in a variety of models that will leave you grinning from ear-to-ear. To learn more, visit www.PolarisSlingshot.com.


Skin tone and texture can greatly affect one's appearance. Learn more about skin tone and texture at HowStuffWorks.
Do tanning pills work? We explain how these capsules may or may not boost your skin care routine. Read on to learn the in's and out's of tanning pills.
Nobody's perfect, and even adults with enviable complexions probably have at least a few blemishes they want to correct or hide. Fortunately, a reasonably even skin tone is achievable.
It's a fact of life: Your skin ages just like the rest of you. But there are some steps you can take to lock moisture in for smoother skin.
Thanks to airbrushing and professional makeup artists, most celebrities seem to look perfect all the time. But even in the rarefied air of glamorous stardom, some celebrities are known for gorgeous skin. Check your jealousy at the door for this list.
These getting beautiful skin pictures show some great ways to take care of your skin. Check out beautiful skin pictures here.
The ways to get that sun-kissed glow safely will differ depending on your shade of skin. What kinds of sunscreens and sunless tanning lotions are right for your skin tone?
It's widely known that melanin is produced in response to sun exposure. So why is that skin tones vary from region to region - no matter how close or far away someone is from the equator, where UV radiation is at its highest?
Do you simply look more beautiful when you're wearing certain colors? It's because your skin tone is complimented by particular hues. How do you know which ones?
When flashbulbs start popping, do you cringe instead of saying cheese? We've got the inside scoop on how to get your skin tone ready for its close-up.
Since they're derived from wholesome milk, it's no wonder that lactic acid products can give you smoother, healthier-looking skin. But do your homework -- not all of them are created equal.
Your skin is your armor, and without it, you would be nothing more than a pile of muscles, bones and organs. And the texture of your skin can tell a lot about the way you treat it.
If you've got a skin care regimen that involves a cleanser and a moisturizer, toner might seem a bit superfluous. But if you add the right kind to your routine, your skin will really benefit.
Imperfections come in the form of sunspots, freckles, red blotchy areas and countless others. But lucky for us, there are a few tricks we can use to try and even the tone out.
Our skin does much more than make us look good -- it's our largest organ. Learning how to identify your skin's exact tone will help you protect it from the elements.
If you want to get the flawless skin of a celebrity on a magazine cover, you're probably out of luck -- those photos go through heavy retouching. But there are things you can do to improve your skin texture.
Why do you look your best in some colors, while others make you look washed out, pale or ruddy? The answer may be in your seasonal skin tone.


In presenting 25 industrial sites of national significance in the context of changing techno-economic paradigms, this book considers the development of Danish industrial landscapes and built-up environments in the period 1840-1970.
Three case studies of ports, sugar mills, and cement plants are also presented. The book concludes with two chapters that discuss perceptions and strategies for the conversion of industrial sites, and an overview is given covering the preservation of industrial heritage in Denmark, historically.
The book is published by Aarhus University Press in cooperation with the Danish Agency for Culture, January 2014.


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<TITLE>Review for JFK (1991)</TITLE>
<LINK REL="STYLESHEET" TYPE="text/css" HREF="/ramr.css">

JFK (1991)

reviewed by
Ralph Benner

                                   JFK
                       A film review by Ralph Benner
                        Copyright 1996 Ralph Benner

     In the February 1992 Vanity Fair, no less than Norman Mailer wrote
that despite director Oliver Stone's clumsiness with facts, "The first
thing to be said about JFK is that it is a great movie, and the next is
that it is one of the worst great movies ever made." Leave it to Mailer to
have it both ways, but he's doing nothing that Stone himself is not: JFK
confirms that the Warren Report is bunk; it also has built-in protections
against criticism that Stone's hero, New Orleans district attorney Jim
Garrison, was discredited back in the late 60s when he attempted to prove
a wide conspiracy in John Kennedy's assassination. Clever of Stone to put
those fail-safes into the movie's Garrison. And clever of Mailer to avoid
refuting much of Stone's composite theory. It's been years since I've seen
a movie I consciously fought against seeing -- but ended up loving. Trying
to avoid JFK had nothing to do with what Stone was doing with the
purported facts and the ever-expanding periphery of lies, concoctions,
suppositions; he is, after all, THE movie provocateur of our time and it's
his undisputed right to scorn whatever or whoever he wishes. I hesitated
because I didn't want to see that g.d. Zapruder home movie again, or have
to once again swallow the claims the Warren Commission didn't cover up
what happened. We all feel, no matter what side we take, that whatever the
government not only really knows but also what it doesn't know about
Kennedy's death, it isn't sharing. It's morally unconscionable that an
unelected committee has the authority to deny us files associated with the
assassination and enforce that they be kept from disclosure until 2029 --
when the Kennedy and pre-Kennedy generations will be goners. A simple
question: What are "they" hiding? Considering the torrent of obfuscation,
we the living and -- much worse -- history may never know. (I agree with
Edmund Berkeley's prediction: LBJ, with a little help from J. Edgar,
Dulles, perhaps Nixon, instigated a coup d'etat. And inspite of his
lengthy, detailed "Oswald's Tale: An American Mystery," Mailer himself
concludes that he's only about 75% sure that Oswald did it, and maybe only
60% sure that it did it alone. Not enough for a conviction.) This
inconclusiveness the stuff of conspiracy: the government hasn't any
irrefutable evidence to support the "lone nut with a rifle" theory -- and
Stone's greatest contribution is in destroying, once and for all, Lee
Harvey Oswald's marksmanship: not only do Oswald's own military records
indicate that he was less than average as a shot, but Gerald Ford, the
only living enthusiast-patsy of the Warren Commission, cheerfully embraces
the psychodramaturgy that Oswald was a "failure," "sexually impotent, a
"victim" of his wife's constant berating, all of which suggests an
emotional instability that lessens his chances of being able to fire off,
with trees obstructing his view, three rounds from a cheap 6.5 Italian
Carbine in roughly six seconds. (One round fired in 0.9 of a second after
a previous shot -- an impossibility.) Then there's the "magic" bullet --
the pristine projectile that's the crux of the Warren Report. Ballistics
proved it came from Oswald's rifle, yet in exhaustive tests, it was proved
not to be the bullet that hit John Connally. Neither could ballistics
prove when the bullet was fired nor has anyone explained how it ended up
on a Parkland Hospital stretcher. The commission ignored the ballistics
conclusions. The disturbing multi-part documentary "The Men Who Killed
Kennedy," shown on A & E's "Investigative Reports," produces convincing
eyewitnesses who claim one of the shots that struck the president was
indeed fired from the infamous grassy knoll -- witnesses whose testimony
was omitted from the WR, which also ignored a credible witness who
reported seeing two gunmen aiming from the TBR, and, most discomforting,
accepted an altered autopsy report on Kennedy that's contradictory to what
the Parkland doctors originally claimed. JFK attacks and is an admission
of the fact that we the people have, in the end, zilch power.

     As pure entertainment, JFK is the American movie of its year.
That's its major surprise. Making it inexplicably great is that many of us
still can't figure out how Stone was able to put the jangling disparity
together in such an intensely consumable style. In scene after scene,
we're eating it all up, even when we sense he's gone too far -- especially
with the homosexual and Vietnam angles. He's holding us so rapt that we
get carried along, feeling surges of excitement we haven't felt from movie
viewing in a longer time than we're willing to admit. Of course, if you're
a Warren Report diehard, you'll go crazy; if you're a skeptic, as most
are, submitting to Stone's disputations is rather like reeling from a
pent-up citizenry's vindictive high. The main pleasure is in the acting:
does anyone is this three hour epic give a bad performance? Arguably Joe
Pesci as David Ferry does, if you don't buy into his paranoia. I did: his
performance, like Stone's conspiracy theory, represents a composite of a
tawdry underground; Pesci's style of smoking, eyebrows and hair reek of a
60s effeminacy, yet the internalized fury and craziness are authentic to
the period. (I've met his physical type.) Ed Asner is a square-faced
menace you would think twice about having a drink with; Jack Lemmon does
well his renowned weakling number; Donald Sutherland as -- don't snicker
-- Mr. X is super-riveting as he lists the various possibilities of why
Kennedy got knocked off; Sissy Spacek matches perfectly with megastar
Kevin Costner; John Candy and Kevin Bacon are prime comic relief; and
Tommy Lee Jones, as Clay Shaw/Bertrand, is resurrected as an actor. Even
the real Jim Garrison, looking as if near death (and was), shows up as
Chief Justice Earl Warren.

     Kevin Costner's portrayal of Garrison is not accurate on many
accounts, but Stone's intention is not to depict him as he really was,
because that might have left us with a character not entirely sympathetic.
There was and still is something heroic in Garrison's persistence in
establishing substantial doubt about the excessively wordy Warren Report;
but there was nothing but pity and strange, pathetic ridicule left when in
real life he was denied at every turn his chance to prove his case --
because all of his central witnesses died before the trial. (This irony
supports conspiracy buffs.) Stone sees Costner as a 90s narrator of a
smorgasbord docudrama about alleged facts that have come to light long
after Clay Shaw was acquitted of any links to Kennedy's death. This is the
central reason why Costner's summation runs on and on -- Stone wants to
get every conceivable denunciation he can on the filmic record. With the
exception of BULL DURHAM, in which he was absolutely dead-on, Costner
usually works against himself: he looked like a Playgirl photo op in
SILVERADO; he was puny in and misfitted for NO WAY OUT and THE
UNTOUCHABLES; in DANCES WITH WOLVES his voice-overs wiped out the tanned
romantic illegitimacy of his soldier & Indians fantasy. As executive
producer of REVENGE, he was plucking so hard to save the bomb that he lost
sight of whatever tiny vision of a movie he was making. His voice proves
he's no ROBIN HOOD: PRINCE OF THEIVES. (A rushed movie, the only things
worth commending are Mary Elizabeth Mastrantonio's unexpected
user-friendliness and some top notch action sequences.) Here in JFK,
Costner's vocal limitations are noticeable only in that he's providing a
southern accent as affectation that Garrison didn't have or use. In bad
clothes, pedestrian glasses and with touches of gray in his hair, he's
deglamourized; he's so earnestly bland that while most everyone else
around him leaps with paranoid energy, he gains our respect by his sheer
ordinariness.

     In a speech before the National Press Club in Washington,
televised by C-SPAN, Oliver Stone said of the WR, "Ladies and gentlemen,
this is not history, this is myth. It is myth that a scant number of
American have ever believed. It is a myth that has sustained a generation
of journalists and historians who have refused to examine it, who have
refused to question it, and, above all, who close ranks to criticize and
vilify those who do. Some journalists from the 60s are self-appointed
keepers of the flame. They talk about our history and fight savagely those
who would question it. But confronted with the crime of the century with
no motive and hardly any alleged perpetrators, they stand mute." A few
days after the speech, Andy Rooney, on 60 Minutes, joked that Stone was
this era's Orson Welles looking for his Rosebud. Rooney unwittingly
confirmed Stone's legitimate deploring of our dangerously lazy press: the
Rosebud of JFK may be LBJ. (Perhaps if he lives to be able to complete his
multi-volume biography of Johnson, author Robert A. Caro will corroborate
Stone's contention.) What Stone has really made is his own and much more
horrifying and brutal MANCHURIAN CANDIDATE. Stone's polemic is
counter-myth, a refutist's grand mal that gets carried away with spasms of
conjecture and invective. It's dazzling, work-me-over movie making in the
most flagrant traditions of disreputable press muckraking -- what Ayn
Rand's Ellsworth Toohy might accomplish if he were a frothing liberal let
loose on The Banner. As you watch the movie unfold, and after you leave
the theatre, you think the worst possible thoughts about everybody.
Stone's message is much beyond his multi-layered conspiracy: he's
admonishing all of us for acquiescing to the volumes of prevarication. JFK
makes us feel used, abused and powerless. This combo is the movie's
clarion call.

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rec.arts.movies.reviews newsgroup (de.rec.film.kritiken for German reviews).

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belongs to the author.

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redpajama_set_name: RedPajamaGithub


text:
Faculty of Arts and Sciences
FAS Theses and Dissertations
A Role for Nucleoporin Nup211 in Centromere Structure and Function in Schizosaccharomyces Pombe
Morris_gsas.harvard_0084L_10053.pdf (13.43Mb)
Full text of the requested work is not available in DASH at this time ("dark deposit"). For more information on dark deposits, see our FAQ.
Morris, Corey
Morris, Corey. 2011. A Role for Nucleoporin Nup211 in Centromere Structure and Function in Schizosaccharomyces Pombe. Doctoral dissertation, Harvard University.
Eukaryotic centromeres are the region upon which kinetochores assemble, directing attachment of spindle microtubules and faithful segregation of chromosomes during mitosis and meiosis. Except for a transient disruption in mitosis when chromosomes are segregated, centromeres of fission yeast Schizosaccharomyces pombe remain closely associated with the nuclear periphery. Similar to multicellular eukaryotic centromeres, they also maintain unique chromatin architecture, with a central core defined by the presence of the conserved centromeric histone H3 variant CENP-A, designated Cnp1 in S. pombe, that is flanked by histone H3 containing heterochromatin. While much progress has been made in understanding chromatin-associated factors important for proper centromere function, many questions remain. In order to gain a better understanding of the factors involved in centromeric chromatin structure, we affinity purified and defined by mass spectrometry interactions among select proteins that had been implicated in proper Cnp1 localization and centromere function. These biochemical purifications revealed several proteins that may be involved in Cnp1 localization. Purification and analyses of Cnp1 also led us to the identification of the Mlp1/Tpr nucleoporin homolog Nup211. We have found that Nup211 interacts with components of the inner nuclear basket of the nuclear pore, and co-purifies with centromeric chromatin proteins. Cells lacking Nup211 have substantial chromosome segregation defects, as observed by synthetic growth assay, flow cytometric analysis, and fluorescent microscopy. A series of immunoprecipitation experiments have revealed that Nup211 associates with centromeric DNA, and that, surprisingly, cells lacking Nup211 have increased histone H3 lysine 9 methylation, a marker of heterochromatin, and a reduction in Cnp1 levels at the central core. Moreover, cells lacking Nup211 have decreased transcription at centromeric loci, disruption of the stereotypical nucleosome structure found at the central core of S. pombe, and show striking changes in the distribution of heterochromatic foci in the nucleus. By demonstrating that Nup211 is essential for the maintenance of normal central core chromatin state, these studies have shed light on a novel role for Nup211 in proper centromere structure and function in S. pombe, and suggest that Nup211 may play a role in preventing the invasion of flanking pericentric heterochromatin into the central core of centromeres.
http://nrs.harvard.edu/urn-3:HUL.InstRepos:10336919
FAS Theses and Dissertations [6266]
Contact administrator regarding this item (to report mistakes or request changes)


Bottom Line: Statewide implementation of mandatory policies to screen newborns for the most serious congenital heart defects was associated with an estimated decrease in infant cardiac deaths.
Why The Research Is Interesting: Congenital heart disease accounted for 6 percent of U.S. infant deaths from 1999 to 2006. In 2011, critical congenital heart disease was added to the U.S. Recommended Uniform Screening Panel for newborns but it is not known if the policy requiring screen for the most serious defects is associated with lower infant death rates.
Who and When: Infants born between 2007 and 2013.
What (Study Measures): Before-after comparison of early infant deaths (between 24 hours and 6 months of age) from critical congenital heart disease or other congenital cardiac causes in states with mandatory vs nonmandatory screening policies. As of June 2013, eight states had implemented mandatory screening policies, five states had voluntary screening policies, and nine states had adopted but not yet implemented mandates.
How (Study Design): This is an observational study. Researchers are not intervening for purposes of the study so they cannot control natural differences that could explain the study findings.
Authors: Rahi Abouk, Ph.D., William Paterson University, Wayne, New Jersey, and coauthors.
Results: There was a decrease in estimated infant cardiac death rates for states that implemented mandatory screening policies compared to states that did not.
Study Limitations: Estimates of death rates were imprecise because of the small number of deaths and the small number of states with fully implemented screening mandates.
Study Conclusions: The findings support the use of statewide policies requiring newborn critical congenital heart disease screening as one means to reduce U.S. infant mortality.
The editorial, "The Success of State Newborn Screening Policies for Critical Congenital Heart Disease," by Alex R. Kemper, M.D., M.P.H., M.S., of Nationwide Children's Hospital, Columbus, Ohio, and coauthors.


text:
Short Starts: "Jane Eyre" Director Cary Fukunaga's "Victoria Para Chino"
Short Starts: "Jane Eyre" Director Cary Fukunaga's "Victoria Para Chino"
Daniel Walber
Mar 7, 2011 4:50 am
@@DSWalber
When I heard that Cary Fukunaga was attached as director to Focus Feature's "Jane Eyre" (which opens in limited release this Friday), I have to admit that I was a little surprised. It's not that I don't think he's up to the job; he's an incredibly talented director, whose 2009 debut feature, "Sin Nombre," was one of my favorites of that year. Rather, I was struck because an adaptation of a 19th century English literary classic is a distant jump from his prior work. Both "Sin Nombre" and his award-winning student film "Victoria Para Chino" are gritty and honest explorations of illegal immigration into the US via the Mexican border, powerful stories of humanity on the move. This short film is available on iTunes.
"Victoria Para Chino," a thirteen minute portrayal of the border-crossing experience, is particularly focused and unencumbered by unnecessary stylistic flair. Chino, who we can assume has actually had one of the shorter journeys of his fellow travelers, is in an almost privileged position amongst the group that boards the truck bound for Houston. He, like presumably much of the audience, is unfamiliar with the grand scope of things. But unlike in "Sin Nombre," where Fukunaga has the length of a feature film to show the intricacies of migration across Central and North America, this short film focuses on the sheer impact of a single border crossing.
Chino, naïve but also unassuming, climbs into the truck with 79 other men, women and children. Fukunaga is uncompromising; the darkness is real, and he uses sound to bring the viewer into this cramped and terrifying space in the trailer of this truck. The sense of urgency is palpable, only helped along by the bare bones imagery. As things go wrong and the confusion and panic heightens, there is only the juxtaposition of the trucker and his country radio station; he drives along, completely out of touch with the alarm going on just behind him.
But there is more to this moment than the dichotomy of trucker and immigrant. Fukunaga, like any great short filmmaker, uses the brief length of the film and an almost vérité simplicity of style to pose bold questions as abruptly as they occur outside the film. Which is more important: the health of a single passenger or the urgency of an entire group's drive to make it into the US?
The reality of this tragedy and the scope of its theme give this film a fairly powerful punch, but it's the close and direct filmmaking ability of its director that really drives it home. These thirteen minutes serve as a distilled exploration into a part of our world that is often dealt with only in terms of rhetoric, and do so with a palpable veracity. Check it out.
Follow Spout on Twitter (@Spout) and be a fan on Facebook
Follow Dan Walber on Twitter (@dswalber)
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text:
Giffords Law Center to Prevent Gun Violence. 2023 'State Right to Bear Arms in Florida.' Other Laws & Policies. San Francisco, CA: Giffords Law Center to Prevent Gun Violence. 31 January
[Editor's note: The Giffords Law Center to Prevent Gun Violence regularly updates its webpages with new data as US gun regulation evolves state by state. For the most up-to-date information on US gun laws, please refer to the Giffords URL below]
State Right to Bear Arms in Florida
Article I, § 8(a) of the Florida Constitution provides: "[t]he right of the people to keep and bear arms in defense of themselves and of the lawful authority of the state shall not be infringed, except that the manner of bearing arms may be regulated by law."
The Supreme Court of Florida has held that the Florida Legislature has broad authority to regulate firearms for public health and safety purposes. In Rinzler v. Carson, the court held that a statute prohibiting the possession of a short-barreled long gun or a machine gun, Florida Statutes Annotated § 790.221, was a constitutional exercise of the state's police power. The court established that "the right to keep and bear arms is not an absolute right, but is one which is subject to the right of the people through their legislature to enact valid police regulations to promote the health, morals, safety and general welfare of the people." The court concluded that "the Legislature may prohibit the possession of weapons which are ordinarily used for criminal and improper purposes and which are not among those which are legitimate weapons of defense and protection" within the meaning of Fla. Const. art. I, § 8(a).
The court also held, however, that section 790.221 did not prohibit the possession of "weapons not concealed upon the person, which, although designed to shoot more than one shot semi-automatically, are commonly kept and used by law-abiding people for hunting purposes or for the protection of their persons and property, such as semi-automatic shotguns, semi-automatic pistols and rifles." Although the court stated that an absolute ban on such weapons might violate the people's ability to "keep and bear arms," the court noted that the Legislature "can regulate the use and the manner of bearing certain specific weapons."
Other Florida Supreme Court cases have rejected challenges based on the precursor to Fla. Const. art. 1, § 8(a) (former "§ 20″ of the Declaration of Rights of the Florida Constitution (1885) )…
https://giffords.org/lawcenter/state-laws/state-right-to-bear-arms-in-florida/


When you submit an order to Antiques Buddha, via our web site you are offering to purchase from Antiques Buddha Collection those items set out your order. Payment details must be provided at time of submission. No products will be delivered before full payment is received. All payments must be approved or cleared before orders can be dispatched. As customer, you are liable for any fees or changes imposed for any payments from your nominated card or nominated debit account. All payments will be processed in Euro and converted into Dollar.
We believe that our photographs and description show and describe our products as accurately as possible, however colors of products may differ slightly from appearance online. Antiques Buddha Collection cannot be held responsible for marginal differences in the products. Antiques Buddha Collection sells original Buddha statues and rest assure that each piece that you purchased is valuable and unique.
You state that you have read and agree to the above mentions terms.
Antiques Buddha endeavors to maintain our policies that each of our antique products will be served in a good condition usable and met our customer's satisfaction. However, if you are not satisfied with, please notify us within 7 days and return your piece within 10 days for a full refund, items must be returned in the same condition they were shipped to you and the buyer bears the return shipping charge and must carefully pack the items for return. If the piece arrives broken or damaged, we return the end price only.
Antiques Buddha uses a professional shipping company to carefully pack the merchandise. In order to protect the antique products from any possible damage during handling or in transit. The piece is bubble-wrapped and secured by foam sheets and we use hard cardboard to tightly wrap each item , with this procedure, the possibility of damage is minimized, all shipments are fully insured against loss, we shipping from Bangkok (Thailand).
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text:
NGON & 5G Transport is part of the Informa Tech Division of Informa PLC
Center Expo Congress Mandelieu-La NapouleCote d'Azur
30th May: Pre-Conference Day
31 May - 1 June: Main Conference and Exhibition
Event Features
VIP Programme
Attendee Testimonials
Register interest for 2023
2023 reg
Center Expo Congress Mandelieu-La Napoule,
Advisory Board 2019
We have invited some of the industry leaders to offer their expertise, knowledge and guidance throughout programme creation.
The Advisory Board will help shape the key topics for the agenda, assist with feedback on technical papers submitted, provide perspectives on opinion pieces throughout the run-up to the event, and offer comment on the nominations received for the prestigious NGON & DCI Awards.
Brad Booth, Principal Engineer, Microsoft
Brad Booth is a long-time leader in Ethernet technology development and standardization. Currently heading up the 25/50G Ethernet Consortium and the Consortium for On-Board Optics, he is a Principal Engineer at Microsoft, where he leads the development of hyperscale interconnect strategy for Microsoft's cloud data centers. He is also the founder and past Chairman of the Ethernet Alliance. Brad was previously a Distinguished Engineer in the Office of the CTO at Dell Networking, where he developed Dell's next generation server-storage-networking fabric strategy. He has also held senior strategist and engineering positions at Applied Micro, Intel, and PMC-Sierra. The holder of 14 patents related to networking technologies, he has received awards from the IEEE Standards Association for work on Ethernet standards and awards for his contributions to Gigabit Ethernet, 10 Gigabit Ethernet, Backplane Ethernet and Ethernet in the First Mile. He was listed as one of the 50 most powerful people in networking by Network World magazine.
Heavy Reading
Sterling Perrin, Senior Analyst, Heavy Reading
Sterling has more than 15 years' experience in telecommunications as an industry analyst and journalist. His coverage area at Heavy Reading is optical networking, including packet-optical transport. He also authors Heavy Reading's Packet-Enabled Optical Networking Market Tracker and Next-Gen Core Packet-Optical Market Tracker. Sterling joined Heavy Reading after five years at IDC, where he served as lead optical networks analyst, responsible for the firm's optical networking subscription research and custom consulting activities. Sterling is a frequent speaker at telecom industry events and a highly sought-after source among the business and trade press.
Ralf Kattner, Lead – Optical Networks, Telefonica
Ralf joined Telefónica in 2006. He is currently leading Telefónica Germany's team "Optical Networks" being responsible for the nationwide transmission backbone supporting nearly 50 million subscribers. Before joining Telefónica, Ralf had been with Ericsson and Nokia developing mobile networks and network management systems.
He received his Ph.D. in Computer Science at the Leibniz University of Hannover, Germany, after having successfully completed his Diploma in Electrical Engineering at the Technical University of Munich, Germany. Network architectures including topology, connection points, bandwidth demands, etc. as well as the evaluation and deployment of the most recent WDM technology are within his main focus. Telefónica Germany is currently performing a transformation of its backbone towards partially disaggregated WDM networks.
Xiang Liu, VP Optical Technologies, Huawei
Xiang Liu has more than 20 years of experience in the optical communication industry. At Huawei, he is responsible for advanced optical technologies and industry development for the transmission and access network product line. Before joining Huawei, Xiang had been with Bell Labs working on high-speed optical transmission technologies for 14 years. Xiang has a Ph.D. degree in Applied Physics from Cornell University. He has authored over 340 publications and holds over 85 US patents. He has served as a General Co-Chair of OFC 2018, and is currently serving as a Deputy Editor of Optics Express and an Executive Committee member of the IEEE ON2020 industry connection activity. Dr. Liu is a Fellow of the IEEE and the OSA.
Andrew Lord, Head of Optical Research, BT
Andrew joined BT in 1985 after a BA in Physics from Oxford University. He has helped design a wide range of optical network systems and technologies, including long haul subsea and terrestrial DWDM networks. He has been responsible for optical fibre and systems specifications. He currently leads BT's optical core and access research including optical access, high speed transmission, Software Defined Networking and Quantum Communications. He regularly speaks at conferences and was Technical Program Chair for OFC 2015 and General Chair for OFC 2017. He is an associate Editor of Journal of Optical Communications and Networking (JOCN), is Visiting Professor at Essex University, Senior Member of the IEEE and a Chartered Engineer with the IET. He currently is project manager for the EU Horizon 2020 project 'Metro-Haul'.
ACG Research
Tim Doiron, Principal Analyst - Intelligent Networking, ACG Research
Tim Doiron is Principal Analyst at ACG Research, leading the firm's Intelligent Networking practice. Doiron's work is focused on network innovations and transformations in the areas of packet optical networking, data center inter-connect, transport/multi-layer software-defined networking, mobile anyhaul and enterprise services virtualization with network function virtualization and vCPE/SD-WAN. Tim has ongoing collaborations in areas of network programmability, visibility, telemetry and automation. Tim has more than 25 years of networking and telecommunications experience across business and technical organizations. He has served in executive and managerial roles: VP/general manager, VP of product management, director of marketing, product manager, business development and software engineering manager at vendor and service provider companies Coriant, Tellabs, ARRIS, Cadant, Ericsson and AT&T Mobility. Tim has extensive experience bringing new products to market. Tim is a frequent speaker at industry conferences and has authored numerous articles. He holds a Master of Business Administration, Webster University; a Master of Science in electrical engineering, Virginia Polytechnic Institute and State University; and a Bachelor of Science degree in electrical engineering, Southern Illinois University. Doiron also holds eight patents and is a member of IEEE and the Optical Society (OSA). He is an active member of the Electrical and Computer Engineering Industrial Advisory Board at Southern Illinois University where he serves as an advisor to the department chair.
Ian Redpath, Practise Leader - Components, Transport & Routing, OVUM
Ian is a Principal Analyst with Ovum's Intelligent Networks practice. He leads and supports Ovum's syndicated research and publications on optical networks, optical components and Enterprise Ethernet services. He is currently leading new research on the rapidly growing Data Center interconnect market. He is a regular speaker, panelist and moderator at industry, service provider and system vendor events. He also contributes to setting the agenda for many industry events, including the OFC's Market Watch, MEF's GEN2014-16 Event series and the IIR's WDM and Next Generation Optical Networking conference series. He also conducts custom research and consulting for clients. His clients include communications service providers, rights-of-way owners, system vendors, components vendors and the financial/legal communities. His recent custom efforts have included evaluating service provider market entry strategies; sizing dark fiber markets; competitive analysis of a regional data center market; assessing vertical market opportunities and sizing the data center interconnect market. Prior to his work in the analyst community, Ian started with system vendors: Nortel, Bell-Northern Research and Maryland-based optical start-up Corvis. Ian received his MBA from Queen's University at Kingston, Canada and his BSc in Electrical Engineering from the University of Manitoba.
Meet the speakers
Mervyn Kelly, EMEA Marketing Director, Ciena
Mervyn Kelly is responsible for helping customers and partners improve their business through software and hardware-based network transformation and delivering new revenue streams such as high-performance on-demand cloud services and virtualised IT applications.
He has been in the Telecoms industry for over 20 years, and prior to his current role, Mervyn held EMEA Product Marketing and Business Development senior management positions in the industry covering Carrier Ethernet, Optical, OTN, fibre to the home and IP routing market segments.
Mervyn is a Chartered Engineer and holds a BSc (Hons) degree in Microelectronic Engineering from the University of Ulster.
Heidi Adams, Senior Research Director, IHS Markit
Heidi Adams joined IHS Markit in March 2016, bringing over 20 years of data networking and communications expertise to the team. As the lead analyst for IP & optical network research, she is currently focused on assessing the impact of emerging cloud-centric residential, business and mobile service architectures on the evolution of transport network infrastructure. Throughout her career she has been active in bringing new networking technologies to market for service providers, mobile network operators and large enterprises. Prior to joining IHS Markit, Heidi has held senior roles in product marketing, PLM, technical support, and R&D, at Nokia (Alcatel-Lucent), Nortel Networks, Bell Northern Research and IBM. Heidi holds a Bachelor of Science degree in electrical engineering from Queen's University (Canada) and an MBA from the University of Ottawa.
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Dr. Catherine Cote is a graduate of American International College's Doctor of Physical Therapy program. She is currently pursuing a certification as a Strength and Conditioning Specialist (CSCS) through the National Strength and Conditioning Association. Dr. Cote works on a variety of orthopedic injuries and works with pediatric to geriatric populations. She is a mother of three. When she is not working, she enjoys playing soccer at Allsport in Northampton during the winter season and outdoors in the spring and summer. Dr. Cote also enjoys snowboarding, hiking and all outdoor activities with her family and two rescue dogs.
We at Synergy Physical therapy help to restore the fun in peoples lives through improved movement and function. Make an appointment today.


text:
Q: Using inner join twice Trying to select the Match Table and convert the ID's into the Schools name, but right now I can only get one row to work at a time. What would my select look like instead?
select Match.ID, School, GuestTeamID from Match
inner join Team on team.id = match.HomeTeamID

Match Table
+------------+------------+-------------+
|         ID | HomeTeamID | GuestTeamID |
+------------+------------+-------------+
|          1 |          1 |           2 |
|          2 |          3 |           4 |
+------------+------------+-------------+

Team Table:
+----+----------+
| ID |  School  |
+----+----------+
|  1 | School A |
|  2 | School B |
|  3 | School C |
|  4 | School D |
+----+----------+

A: Join Team table twice with Match table to fetch school name.
Try this:
SELECT M.ID, t1.School AS HomeSchool, t2.School AS GuestSchool
FROM MATCH m
INNER JOIN Team t1 ON t1.id = m.HomeTeamID
INNER JOIN Team t2 ON t2.id = m.GuestTeamID;


Have you ever wanted to work on robots? Do you enjoy getting hands-on with exciting cutting-edge technology? Are you interested in working for a global company right here in Chattanooga? If your answer to any of these questions is "yes," then we want you to come check out the Volkswagen Academy at this year's open house. Come and learn more about the training programs we offer and explore our state-of-the-art training facility.
The Robotronics Technology Expert Apprenticeship is a two-year program that combines academics with hands-on training to prepare future employees for careers at Volkswagen Chattanooga. The Volkswagen Academy is currently recruiting for the 2019 cohort and will accept onsite applications.
The onsite high school program allows 11th and 12th grade students to complete their High School education at the state-of-the-art Volkswagen Academy and prepares them to take the next step into the Volkswagen Apprenticeship program. Hamilton County Schools is accepting students for the 2019-2020 school year.
Volkswagen Chattanooga offers several internships to local college students in various business areas each year.Volkswagen Chattanooga is currently recruiting for summer 2019 and will accept onsite applications.


text:
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Business, Fashion
Why fashion loves to revive heritage brands
Editorial Teamon November 8, 2014 /Comments closed
This article titled "Why fashion loves to revive heritage brands" was written by Lauren Cochrane, for theguardian.com on Friday 7th November 2014 12.26 UTC
Credited with pioneering designer perfume, doing away with the corset and throwing some great parties, Paul Poiret was a giant of Parisian fashion in the 1910s. If his name has been consigned to history – and many a designer's moodboard – in the 100 years since, there are signs it could be about to gain new life. The trademarks for his house have been put up for auction this month, suggesting a revival.
French fashion designer and decorator Paul Poiret, 1922. Photograph: Lipnitzki/Roger Viollet/Getty Images
Poiret 2.0 is part of a wider trend. A glut of fashion houses from the first half of the 20th century have relaunched with great success in the past 10 years, often getting a completely new spin in the process: see Balmain, Carven and Schiaparelli. The heritage that comes with an established name – even if the customer is only vaguely aware of it – bolsters these labels, even if that said heritage isn't in the least plundered. Pierre Balmain, known for buttoned-up elegance and dresses worn by royalty in the 50s, is a long way from Balmain's current preoccupation with sex and social media. Martin Raymond, the co-founder of trends forecasting consultancy The Future Laboratory, believes it's this combination of new and old that appeals to potential investors. "The whole business model is both about heritage fashion and a relatively blank canvas to write new codes," he says. The perfumes that Poiret made are an added bonus – to relaunch these along with a catwalk collection would draw in a consumer who loves the associations but can't afford the clothes.
A model at the Schiaparelli show at Paris Fashion Week. Photograph: Victor Virgile/Gamma-Rapho via Getty Images
Poiret is currently owned by Arnaud de Lummen, of Levanis SA. De Lummen was behind the relaunch of Vionnet – another example of how heritage works now. The house, set up by Madeleine Vionnet in 1912 and famous for draping, was dormant for nearly 75 years but is now a very modern kind of fashion success: on the Paris schedule, owned and designed by Kazakh businesswoman Goga Ashkenazi and worn by well-heeled women around the world. "Ashkenazi is very aware of what women want and how to make them feel elegant," says Sasha Sarokin, the buying manager at Net-a-Porter. "The Vionnet customer wants to wear something special without any fuss."
Carven, another heritage brand that was revived in the 1990s. Photograph: Victor Virgile/Gamma-Rapho via Getty Images
Arguably, this latest cluster of houses are cult references of 20th-century fashion rather than household names such as Chanel or Christian Dior, which means designs have the freedom to reflect something more modern. "Investment companies are looking for a vehicle to potentially create new luxury brands," says Raymond. "It's a name that's in museums, in fashion history books – which shows they're targeting a fashion-literate consumer." Said consumer is likely to be shopping on sites such as Net-a-Porter, so a new Poiret is on Sarokin's radar. "It's always very exciting for us to see new brands emerging and heritage brands being rejuvenated," she says. "Poiret was famous for his feminine and wearable looks, so we're incredibly excited to see what happens with the brand now."
Raymond believes the key to the success is down to the talent taking over the design reins. With John Galliano now in place at Maison Martin Margiela, the obvious choice is taken. "Galliano exemplifies the lushness of colour and the journey of a brand like that," he says. "Roland Mouret could work or Christian Lacroix, perhaps." Paul Poiret 100 years ago was a label familiar to, and loved by, the high-fashion consumer. If the pieces fall into place this month, It's only a matter of time before it is once again.
Tagged: #fashion Article Balmain Balmain relaunched Blogposts Carven Carven relaunched decorator Paul Poiret Fashion blog fashion designer Paul Poiret fashion trends forecasting Features heritage brands heritage fashion heritage fashion brands heritage luxury brands Lauren Cochrane Life and style Madeleine Vionnet Martin Raymond Paris Fashion Week Parisian fashion Paul Poiret Paul Poiret fashion Paul Poiret fashion brand Pierre Balmain Poiret 2.0 revive heritage brands revived heritage luxury brands Schiaparelli Schiaparelli relaunched Schiaparelli show Schiaparelli show at Paris Fashion Week The Future Laboratory trends forecasting consultancy
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british journal of cancer
Article | Published: 22 May 2019
Physical activity during adolescence and risk of colorectal adenoma later in life: results from the Nurses' Health Study II
Leandro Fórnias Machado de Rezende1,2 na1,
Dong Hoon Lee2 na1,
NaNa Keum2,3,
Katharina Nimptsch2,4,
Mingyang Song2,5,6,7,
I-Min Lee7,8,
José Eluf-Neto1,
Shuji Ogino7,9,10,
Charles Fuchs11,
Jeffrey Meyerhardt12,
Andrew T. Chan5,6,10,13,14,
Walter Willett2,7,13,
Edward Giovannucci2,7,13 &
Kana Wu2
British Journal of Cancervolume 121, pages86–94 (2019) | Download Citation
Physical activity during adulthood has been consistently associated with lower risk of colorectal cancers, but whether physical activity during adolescence may also play a role in colorectal carcinogenesis is unclear.
We included 28,250 women in the Nurses' Health Study II who provided data on physical activity during adolescence (ages 12–22 years) in 1997 and underwent lower bowel endoscopy (1998–2011). We used logistic regression models for clustered data to examine the association between physical activity during adolescence and risk of adenoma later in life.
Physical activity during adolescence was inversely associated with risk of colorectal adenoma (2373 cases), independent of physical activity during adulthood. The multivariable-adjusted odds ratio (OR) of adenoma was 0.89 (95% CI 0.77–1.02; Ptrend = 0.03) comparing women with ≥ 72 metabolic equivalent of tasks-hours/week (MET-h/week) to < 21 MET-h/week. Women with high physical activity during both adolescence (≥53.3 MET-h/week) and adulthood (≥23.1 MET-h/week) had significantly lower risk of adenoma (all adenomas: OR 0.76; 95% CI 0.66–0.88; advanced adenoma: OR 0.61; 95% CI 0.45–0.82) compared to women with low physical activity during both stages of life.
Our findings suggest that physical activity during adolescence may lower the risk of colorectal adenoma later in life.
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World Cancer Research Fund/American Institute for Cancer Research. Physical activity and risk of cancer. Continuous Update Project Expert Report 2018. (WCRF/AICR, London, UK, 2018).
Leslie, A., Carey, F. A., Pratt, N. R. & Steele, R. J. The colorectal adenoma-carcinoma sequence. Br. J. Surg. 89, 845–860 (2002).
Vogelstein, B., Fearon, E. R., Hamilton, S. R., Kern, S. E., Preisinger, A. C., Leppert, M. et al. Genetic alterations during colorectal-tumor development. N. Engl. J. Med. 319, 525–532 (1988).
Siegel, R. L., Miller, K. D., Fedewa, S. A., Ahnen, D. J., Meester, R. G. S., Barzi, A. et al. Colorectal cancer statistics, 2017. CA Cancer J. Clin. 67, 177–193 (2017).
Clarke, M. A. & Joshu, C. E. Early Life Exposures and Adult Cancer Risk. Epidemiol. Rev. 39, 11–27 (2017).
Nimptsch, K., Giovannucci, E., Willett, W. C., Fuchs, C. S., Wei, E. K. & Wu, K. Body fatness during childhood and adolescence, adult height, and risk of colorectal adenoma in women. Cancer Prev Res 4, 1710–1718 (2011).
Nimptsch, K., Malik, V. S., Fung, T. T., Pischon, T., Hu, F., Willett, W. et al. Dietary patterns during high school and risk of colorectal adenoma in a cohort of middle-aged women. Int. J. Cancer 134, 2458–2467 (2014).
Nimptsch, K., Bernstein, A. M., Giovannucci, E., Fuchs, C. S., Willett, W. C. & Wu, K. Dietary intakes of red meat, poultry, and fish during high school and risk of colorectal adenomas in women. Am. J. Epidemiol. 178, 172–183 (2013).
International Agency for Research on Cancer (IARC). Weight Control and Physical Activity. (IARC press, Lyon, 2002).
Rezende, L. F. M., Sá, T. H., Markozannes, G., Rey-López J. P., Lee, I. M., Tsilidis, K.K. et al. Physical activity and cancer: an umbrella review of the literature including 22 major anatomical sites and 770 000 cancer cases. Br. J. Sports Med. 52, 826–833 (2018).
Wolin, K. Y., Yan, Y. & Colditz, G. A. Physical activity and risk of colon adenoma: a meta-analysis. Br. J. Cancer 104, 882–885 (2011).
Strum, W. B. Colorectal Adenomas. N. Engl. J. Med. 374, 1065–1075 (2016).
Lee, I. M., Paffenbarger, R. S. Jr. & Hsieh, C. Physical activity and risk of developing colorectal cancer among college alumni. J. Natl. Cancer. Inst. 83, 1324–1329 (1991).
Levi, F., Pasche, C., Lucchini, F., Tavani, A. & La Vecchia, C. Occupational and leisure-time physical activity and the risk of colorectal cancer. Eur. J. Cancer Prev. 8, 487–493 (1999).
Tavani, A., Braga, C., La Vecchia, C., Conti, E., Filiberti, R., Montella, M. et al. Physical activity and risk of cancers of the colon and rectum: an Italian case-control study. Br. J. Cancer 79, 1912–1916 (1999).
Nurses' Health Study [internet]. Available at http://nurseshealthstudy.org/. Acessed Feb 27, 2018 (2018).
Bao, Y., Bertoia, M. L., Lenart, E. B., Stampfer, M. J., Willett, W. C. & Speizer, F. E. Origin, Methods, and Evolution of the Three Nurses' Health Studies. Am. J. Public Health 106, 1573–1581 (2016).
Ainsworth, B. E., Haskell, W. L., Herrmann, S. D., Meckes, N., Bassett, D. R. Jr., Tudor-Locke, C. et al. 2011 Compendium of Physical Activities: a second update of codes and MET values. Med. Sci. Sports. Exerc. 43, 1575–1581 (2011).
Ainsworth, B. E., Haskell, W. L., Leon, A. S., Jacobs, D. R. Jr, Montoye, H. J., Sallis, J. F. et al. Compendium of physical activities: classification of energy costs of human physical activities. Med. Sci. Sports. Exerc. 25, 71–80 (1993).
Wolf, A. M., Hunter, D. J., Colditz, G. A., Manson, J. E., Stampfer, M. J., Corsano, K. A. et al. Reproducibility and validity of a self-administered physical activity questionnaire. Int. J. Epidemiol. 23, 991–999 (1994).
Hu, F. B., Leitzmann, M. F., Stampfer, M. J., Colditz, G. A., Willett, W. C. & Rimm, E. B. Physical activity and television watching in relation to risk for type 2 diabetes mellitus in men. Arch. Intern. Med. 161, 1542–1548 (2001).
Hu, F. B., Li, T. Y., Colditz, G. A., Willett, W. C. & Manson, J. E. Television watching and other sedentary behaviors in relation to risk of obesity and type 2 diabetes mellitus in women. JAMA 289, 1785–1791 (2003).
Maruti, S. S., Willett, W. C., Feskanich, D., Rosner, B. & Colditz, G. A. A prospective study of age-specific physical activity and premenopausal breast cancer. J. Natl Cancer. Inst. 100, 728–737 (2008).
Baer, H. J., Schnitt, S. J., Connolly, J. L., Byrne, C., Willett, W. C., Rosner, B. et al. Early life factors and incidence of proliferative benign breast disease. Cancer Epidemiol. Biomarkers. Prev. 14, 2889–2897 (2005).
Jacobs, D. R. Jr., Ainsworth, B. E., Hartman, T. J. & Leon, A. S. A simultaneous evaluation of 10 commonly used physical activity questionnaires. Med Sci Sports Exerc 25, 81–91 (1993).
Chasan-Taber, S., Rimm, E. B., Stampfer, M. J., Spiegelman, D., Colditz, G. A., Giovannucci, E. et al. Reproducibility and validity of a self-administered physical activity questionnaire for male health professionals. Epidemiology 7, 81–86 (1996).
Yuan, C., Spiegelman, D., Rimm, E. B., Rosner, B. A., Stampfer, M. J., Barnett, J. B. et al. Relative validity of nutrient intakes assessed by questionnaire, 24-hour recalls, and diet records as compared with urinary recovery and plasma concentration biomarkers: findings for women. Am. J. Epidemiol. 187, 1051–1063 (2018).
Yuan, C., Spiegelman, D., Rimm, E. B., Rosner, B. A., Stampfer, M. J., Barnett, J. B. et al. Validity of a Dietary Questionnaire Assessed by Comparison With Multiple Weighed Dietary Records or 24-Hour Recalls. Am. J. Epidemiol. 185, 570–584 (2017).
Maruti, S.S., Feskanich, D., Rockett, H.R., Colditz, G.A., Sampson, L.A. & Willett, W.C. Validation of adolescent diet recalled by adults. Epidemiology 4, 226–229 (2006).
East, J. E., Vieth, M. & Rex, D. K. Serrated lesions in colorectal cancer screening: detection, resection, pathology and surveillance. Gut 64, 991–1000 (2015).
Therneau, T. M. & Grambsch, P. M. Modeling Survival Data: Extending the Cox Model. (Springer, New York, 2000).
World Health Organization (WHO). Global Recommendations on Physical Activity for Health. (World Health Organization, Geneva, 2010).
Bibbins-Domingo, K., Grossman, D. C., Curry, S. J., Davidson, K. W., Epling, J. W. Jr., García, F. A. R. et al. Screening for Colorectal Cancer: US Preventive Services Task Force Recommendation Statement. JAMA 315, 2564–2575 (2016).
Johns, L. E. & Houlston, R. S. A systematic review and meta-analysis of familial colorectal cancer risk. Am. J. Gastroenterol. 96, 2992–3003 (2001).
McTiernan, A. Mechanisms linking physical activity with cancer. Nat. Rev. Cancer 8, 205–211 (2008).
Giovannucci, E. A framework to understand diet, physical activity, body weight, and cancer risk. Cancer Causes Control. https://doi.org/10.1007/s10552-017-0975-y (2018). Epub ahead of print 9 Nov 2017.
Friedenreich, C. M. & Orenstein, M. R. Physical activity and cancer prevention: etiologic evidence and biological mechanisms. J. Nutr. 132, 3456S–3464S (2002).
Giovannucci, E. Insulin, insulin-like growth factors and colon cancer: a review of the evidence. J. Nutr. 131, 3109S–3120S (2001).
Yoon, Y. S., Keum, N., Zhang, X., Cho, E. & Giovannucci, E. L. Hyperinsulinemia, insulin resistance and colorectal adenomas: A meta-analysis. Metabolism 64, 1324–1333 (2015).
Verheggen, R. J., Maessen, M. F., Green, D. J., Hermus, A. R., Hopman, M. T. & Thijssen, D. H. A systematic review and meta-analysis on the effects of exercise training versus hypocaloric diet: distinct effects on body weight and visceral adipose tissue. Obes. Rev. 17, 664–690 (2016).
Clarke, S. F., Murphy, E. F., O'Sullivan, O., Lucey, A. J., Humphreys, M., Hogan, A. et al. Exercise and associated dietary extremes impact on gut microbial diversity. Gut 63, 1913–1920 (2014).
O'Sullivan, O., Cronin, O., Clarke, S. F., Murphy, E. F., Molloy, E. F., Shanahan, F. et al. Exercise and the microbiota. Gut Microbes 6, 131–136 (2015).
Blottière, H. M. The gut microbiota and obesity. In: Energy Balancer and Obesity (eds. Romieu, I., Dossus, L. & Willet, W. C.) 89–94 (IARC press, Lyon, 2017).
Boyle, T., Keegel, T., Bull, F., Heyworth, J. & Fritschi, L. Physical activity and risks of proximal and distal colon cancers: a systematic review and meta-analysis. J. Natl. Cancer. Inst. 104, 1548–1561 (2012).
Murphy, N., Ward, H. A., Jenab, M., Rothwell, J. A., Boutron-Ruault, M.-C., Carbonnel, F. et al. Heterogeneity of colorectal cancer risk factors by anatomical subsite in 10 european countries: a multinational cohort study. Clin. Gastroenterol. Hepatol. https://doi.org/10.1016/j.cgh.2018.07.030 (2018).
The authors would like to thank the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School. The authors would like to thank the participants and staff of the Nurses' Health Study II for their valuable contributions as well as the following state cancer registries for their help: AL, AZ, AR, CA, CO, CT, DE, FL, GA, ID, IL, IN, IA, KY, LA, ME, MD, MA, MI, NE, NH, NJ, NY, NC, ND, OH, OK, OR, PA, RI, SC, TN, TX, VA, WA and WY. The authors assume full responsibility for analyses and interpretation of these data. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
These authors contributed equally: Leandro Fórnias Machado de Rezende, Dong Hoon Lee
Departamento de Medicina Preventiva, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
Leandro Fórnias Machado de Rezende
& José Eluf-Neto
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA
, Dong Hoon Lee
, NaNa Keum
, Katharina Nimptsch
, Mingyang Song
, Walter Willett
, Edward Giovannucci
& Kana Wu
Department of Food Science and Biotechnology, Dongguk University, Goyang, South Korea
Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany
Katharina Nimptsch
Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Mingyang Song
& Andrew T. Chan
Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA
, I-Min Lee
, Shuji Ogino
& Edward Giovannucci
Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
I-Min Lee
Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA
Shuji Ogino
Broad Institute of MIT and Harvard, Cambridge, MA, USA
Yale Cancer Center; Department of Medicine, Yale School of Medicine; Smilow Cancer Hospital, New Haven, CT, USA
Charles Fuchs
Dana Faber Cancer Institute, Boston, MA, USA
Jeffrey Meyerhardt
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA
Andrew T. Chan
Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA
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L.F.M.R., D.H.L. and N.K. had full access to all of the data and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: L.F.M.R., D.H.L., N.K., E.G., K.W. Acquisition, analysis or interpretation of data: L.F.M.R., D.H.L., N.K., E.G., K.W., K.N., M.S., I.L., J.E.N., S.O., C.F., J.M., A.T.C., W.W. Drafting of manuscript: L.F.M.R., D.H.L. Critical revision of the manuscript for important intellectual content: all authors. Statistical analysis: L.F.M.R., D.H.L. and N.K. Obtained funding: W.W. and K.W. Study supervision: K.W.
Correspondence to NaNa Keum.
Dr. Fuchs reports consulting role for Agios, Bain Capital, Bayer, Celgene, Dicerna, Five Prime Therapeutics, Gilead Sciences, Eli Lilly, Entrinsic Health, Genentech, KEW, Merck, Merrimack Pharmaceuticals, Pfizer, Sanofi, Taiho, and Unum Therapeutics. He also serves as a Director for CytomX Therapeutics and owns unexercised stock options for CytomX and Entrinsic Health. Dr. Meyerhardt reports consulting role for Ignyta, COTA, Taiho Pharmaceutical (all <$5 K). All other authors declare no competing interests relevant in relation to the work described.
The study protocol was approved by the institutional review boards of the Brigham and Women's Hospital and Harvard T.H. Chan School of Public Health, and those of participating registries as required. Completion of the questionnaire was considered to imply informed consent.
Consent to publish
Further information including the procedures to obtain and access data from the Nurses' Health Study and Health Professionals Follow-up Study is described at https://www.nurseshealthstudy.org/researchers (email: nhsaccess@channing.harvard.edu) and https://sites.sph.harvard.edu/hpfs/for-collaborators.
This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution 4.0 International (CC BY 4.0).
The Nurses' Health Study II was funded by the National Cancer Institute (NCI), National Institutes of Health (UM1 CA176726 to WW). Leandro Fórnias Machado de Rezende receives a doctoral fellowship from the Coordination for the Improvement of Higher Education Personnel (CAPES) and the Sao Paulo Research Foundation (FAPESP), grant #2016/21390–0 and #2014/25614-4. NCI grants R03 CA197879 to KW, R21 CA222940 to K.W. and Reiko Nishihara, R21 CA230873 to K.W. and S.O., R35 CA197735 to S.O., P50 CA127003 to C.S.F. The American Cancer Society (grant number MRSG-17-220-01 – NEC to M.S.). The National Institutes of Health grants K99 CA215314 and R00 CA215314 to M.S. N.K. was supported by grants from the National Research Foundation of Korea (NRF-2018R1C1B6008822; NRF-2018R1A4A1022589); the Dongguk University Research Grant of 2017. This work was also in part supported by an Investigator Initiated Grant from the American Institute for Cancer Research (AICR) to KW.
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