text:
Home » Health News » Glycyrrhizic acid as a drug candidate for COVID-19
Glycyrrhizic acid as a drug candidate for COVID-19
08.25-2021 Health News Comments Off on Glycyrrhizic acid as a drug candidate for COVID-19
Therapies to counteract the damage caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been few and far between, despite efforts to discover new drugs and repurpose already approved drugs that may target the viral proteins.
Without effective therapeutics, clinicians have extended their search into areas of plant-derived compounds. Traditional Chinese medicine (TCM), for example, has yielded several effective compounds against the earlier SARS-CoV and is currently part of the treatment approach of the coronavirus disease 20198 (COVID-19) in China.
Study: Glycyrrhizic Acid: A Natural Plant Ingredient as a Drug Candidate to Treat COVID-19. Image Credit: mirzamlk / Shutterstock.com
The swift development of COVID-19 vaccines and their subsequent rollout in many parts of the world has made considerable progress in reducing the number and severity of COVID-19 cases. Despite their utility, the emergence of new SARS-CoV-2 variants that are less susceptible to neutralizing antibodies (nAbs) elicited by the parental Wuhan strain has challenged the success of these vaccines.
In addition to challenging the efficacy of current vaccines, many of these new SARS-CoV-2 strains are also more transmissible than the wild-type SARS-CoV-2 strain. As a result, there has been a significant rise in COVID-19 infections in many areas around the world, particularly those which have yet to vaccinate a majority of their populations.
In the current study, which was published in Frontiers in Pharmacology, the researchers focused on licorice, which has the active compound glycyrrhizic acid (GA). GA has been found to have antiviral activity, particularly against SARS-CoV-2.
GA benefits in COVID-19
In the current study, GA was found to have both protein-targeting properties and immunomodulatory properties. It also has synergistic activity with many drugs that enhanced its antiviral potential against SARS-CoV-2. This indicates the potential role of GA as a COVID-19 therapy.
In severe and critical COVID-19, the cytokine storm has been well documented and is associated with an increased risk of multi-organ dysfunction or failure, coupled with acute respiratory distress syndrome, and death. In the clinical setting, the potent anti-inflammatory drug dexamethasone, which is a corticosteroid, has been found to improve survival outcomes in this group of COVID-19 patients.
TCM has been widely used in the SARS outbreak of 2002, with claims that it has reduced the mortality rate when used along with Western medicine. Among the most commonly used herbal medicines in TCM is licorice, which is known to have antiviral and antibacterial properties.
GA has been shown in silico to bind to many key SARS-CoV-2 proteins, including the spike, receptor-binding domain, ribonucleic acid (RNA) polymerase, as well as to the angiotensin-converting enzyme 2 (ACE2) receptor, which is the host cell receptor that SARS-CoV-2 binds to when entering cells.
GA and the immune response
The current study shows that GA is an adjuvant to immune activation, and thus enhances the immune antiviral response while the virus is in the incubation period. GA also mutes the cytokine storm caused by SARS-CoV-2, while modulating viral invasion via its effect on steroid metabolism.
In view of its synergistic effect on SARS-CoV-2, GA might reduce the mortality rate of COVID-19. However, further studies are needed to explore its utility as an adjuvant in treating this condition.
SARS-CoV-2 activates CD4+ T-lymphocytes after entering the host cell; however, it also triggers several immune escape mechanisms. This, coupled with the delayed adaptive immune response and the long period required to clear the virus, causes lymphopenia. By promoting T-cell proliferation and by virtue of its adjuvant activity on T-helper type 1 (Th1) cells, GA increases the immune response to SARS-CoV-2.
Secondly, GA causes infected host cells that contain the latent virus to undergo apoptosis, which could help prevent the further spread of the virus.
The Th1-secreted cytokine called granulocyte-macrophage colony-stimulating factor (GM-CSF) is implicated in the release of inflammatory factors and the rapid onset of pneumonia. This involves the expression of interleukin 6 (IL-6), perhaps by the hyper-activation of nuclear factor-κB (NF-κB), which induces a vicious cascade of inflammatory mediator release.
SARS-CoV-2 may bind to lipopolysaccharide (LPS) antigens, further intensifying this NF-κB response, and thus leading to the cytokine storm and ARDS. By inhibiting NF-κB expression, GA could prevent hyper-inflammatory phenomena in COVID-19.
GA can also bind to high mobility group box-1 (HMGB1), which is a biomarker that is associated with acute lung injury (ALI) characteristically seen in severe COVID-19, as well as of severe systemic inflammation. HMGB1 reduces the antimicrobial response of the body and thus increases the risk of death, as well as promotes SARS-CoV-2 invasion and replication. Thus, GA can disrupt these damaging pathways as well, thereby preventing inflammation and ARDS.
GA and COVID-19 comorbidities
Diabetes is a risk factor for severe COVID-19, as it promotes cholesterol uptake into lipid rafts, or cell membrane microdomains rich in lipids. These rafts are attachment points for the virus, thus promoting viral entry into the host cells. GA appears to reduce the invasion of SARS-CoV-2 by reducing lipid raft size.
Cholesterol builds up within the endothelium in hypertension and hypercholesterolemia, which can promote blood clots. Cholesterol also drives platelet aggregation and clot formation.
GA can reduce the cholesterol domain size on the endothelial cell membrane, thus inhibiting these effects. Since GA may cause pseudoaldosteronism and hypertension following its long-term use, spironolactone may be required in these patients.
In metabolic syndrome, a clinical constellation comprising obesity, hyperglycemia, hypertension, and dyslipidemia, the risk of severe COVID-19 and ARDS is high, while LPS levels in the blood are increased. Thus, GA may play a major role in preventing this deterioration.
GA and inflammation
GA also inhibits tumor necrosis factor (TNF)-α, which may prevent severe intestinal inflammation in patients with COVID-19 and irritable bowel syndrome. Further, GA may protect the nervous system through its ability to inhibit apoptosis and HMGB1 activity, which may prevent inflammation and ischemic injury to the brain.
Activating transcription factor 2 (ATF2), which is an inflammatory mediator, mediates the pain associated with inflammation. GA appears to inhibit ATF2 downstream of its activity on P38, thus modulating the pain associated with COVID-19.
GA and steroids
GA can reduce steroid metabolism, which can increase the plasma steroid level, thus preventing shock, as demonstrated in animal models. Thus, corticosteroids and GA could be a synergistic therapeutic approach for COVID-19.
Protective effect of GA in COVID-19
Diabetics are at higher risk for COVID-19; however, new-onset diabetes occurs in about one in seven COVID-19 patients. Perhaps SARS-CoV-2 causes pancreatic islet damage, with resulting failure of insulin secretion and diabetes. Some of the drugs used to treat this infection can also contribute or cause diabetes as a result of their propensity to cause autoimmune disease to the pancreatic islets.
GA has anti-diabetic activity, which enhances its attractiveness in this condition. Moreover, this compound may upregulate the production of inducible nitric oxide synthase enzyme (iNOS), thus promoting the production of NO. This is important, as NO reduces viral replication and ALI due to inflammation, as well as relaxes the pulmonary blood vessels.
This activity by GA may lead to clearing of extracellular fluid from the lung bed, reduce the resistance in the lung vascular bed, and ultimately mitigate ARDS.
GA also protects the liver, and may thus prevent liver injury from the various drugs used at present to treat COVID-19, making it a valuable addition to such protocols.
Schematic diagram of the molecular mechanisms of GA in treating COVID-19. (1) GA promotes the proliferation of T cells and has Th1 cell immune adjuvant activity. (2) GA inhibits the production of IL-6 and the activation of NF-kB. (3) GA inhibits the activity of HMGB1 and the signal transduction of the HMGB1-TLR4 pathway. (4) GA induces the apoptosis of host cells latent with SARS-CoV-2. (5) GA stimulates macrophages to produce NO. (6) GA inhibits the inflammatory response induced by LPS. (7) GA prevents the invasion of SARS-CoV-2 by reducing the domain of lipid rafts.
GA has been used in TCM for a long time as an antiviral and anti-inflammatory compound. Recent research shows its ability to suppress SARS-CoV-2 invasion and replication.
GA appears to bind many SARS-CoV-2 proteins while also having the ability to suppress viral replication. Its ability to assist in the immune response to viruses during the incubation period, dampen the excessive cytokine release, and modulate steroid metabolism make this drug worthy of study in the current attempts to treat COVID-19 more effectively.
Sun, Z., He, G., Huang, N., et al. (2021). Glycyrrhizic Acid: A Natural Plant Ingredient as a Drug Candidate to Treat COVID-19. Frontiers in Pharmacology. doi:10.3389/fphar.2021.707205. https://www.frontiersin.org/articles/10.3389/fphar.2021.707205/full
Posted in: Medical Science News | Medical Research News | Disease/Infection News | Pharmaceutical News
Tags: ACE2, Acute Respiratory Distress Syndrome, Angiotensin, Angiotensin-Converting Enzyme 2, Antibodies, Anti-Inflammatory, Apoptosis, Autoimmune Disease, Biomarker, Blood, Blood Vessels, Brain, CD4, Cell, Cell Membrane, Cell Proliferation, Cholesterol, Compound, Coronavirus, Coronavirus Disease COVID-19, Corticosteroid, Cytokine, Dexamethasone, Diabetes, Drugs, Dyslipidemia, Efficacy, Endothelial cell, Enzyme, Hypercholesterolemia, Hyperglycemia, Immune Response, Immunomodulatory, Inflammation, Insulin, Irritable Bowel Syndrome, Lipids, Liver, Lymphopenia, Macrophage, Medicine, Membrane, Metabolic Syndrome, Metabolism, Mortality, Necrosis, Nervous System, Nitric Oxide, Obesity, Pain, Pharmacology, Platelet, Pneumonia, Polymerase, Proliferation, Protein, Receptor, Research, Respiratory, Ribonucleic Acid, RNA, SARS, SARS-CoV-2, Severe Acute Respiratory, Severe Acute Respiratory Syndrome, Steroid, Syndrome, T-Cell, Therapeutics, Transcription, Tumor, Vascular, Virus
Dr. Liji Thomas
Dr. Liji Thomas is an OB-GYN, who graduated from the Government Medical College, University of Calicut, Kerala, in 2001. Liji practiced as a full-time consultant in obstetrics/gynecology in a private hospital for a few years following her graduation. She has counseled hundreds of patients facing issues from pregnancy-related problems and infertility, and has been in charge of over 2,000 deliveries, striving always to achieve a normal delivery rather than operative.
coronavirusCoronavirus Disea
Previous Post:Xeris Pharmaceuticals Announces Approval of Supplemental New Drug Application (sNDA) of Gvoke Kit for the Treatment of Severe Hypoglycemia
Next Post:The Black Girls Hike guide to the 5 hikes that walkers of all levels can enjoy


text:
Amy Winehouse's new album inspired by Wizard of Oz
Marie Claire August 18, 2008 1:57 pm
Marie Claire News: Amy Winehouse
Amy Winehouse follows yellow brick road for new album
Troubled singer Amy Winehouse has revealed the inspiration behind her
upcoming album – the Wizard of Oz.
Winehouse's follow-up to her Grammy award-winning album Back to Black
will reportedly include samples of the original tracks from the 1939
Judy Garland film.
Along with the title theme song, well-known tracks from the musical
include Over the Rainbow, composed by Harold Arlen.
Winehouse's work on her third album has been delayed by her ongoing
battle with drugs.
Harry and Meghan reportedly plan to produce feature films, comedies and dramas
Melania Trump is coming under fire for 'victimising' herself in the Capitol Hill Riots
She was due to work on the theme tune for the new James Bond film with
DJ Mark Ronson but had to halt work due to health problems.
The commission was given to the American singer Alicia Keys and Jack
White, frontman of The White Stripes instead.
Winehouse's 2006 album was influenced by 1960s soul music while Frank,
her debut album, had a jazz feel. It was nominated for two Brits and the
Mercury Music Prize, and won her an Ivor Novello songwriting award.

redpajama_set_name: RedPajamaCommonCrawl


text:
Q: ArcMap Field Calculator Python string concatenation malfunction I am trying to concatenate three fields into one using Python with the rjust padding function.
My function in the code box is the following:
def AutoSchluessel(gmk, zae, nen):
       return "{}0{}{}".format(gmk, str(zae).rjust(7,"0"), str(nen).rjust(5,"0"))

And the Expression is:
flcode = AutoSchluessel( !gmkgcode!, !zaehler!, !nenner!)

What i am getting is for the fields is the following result:

gmkgcode = 5902;
  zaehler = 32;
  nenner = 17
flcode = 5902.0000032.0017.0

It should in my opinion though result in something without points (59020000003200017).
What am I missing?

A: You need to force the number to not having any decimal digits. Adding int() will solve the problem I think. If the field that holds the original numbers has type of double, it is better to round the number to whole number before add int() function to them.
Here is a code that worked for me, but I tested it on two fields not three fields, as in your case, but you can add another field in the same way:
def AutoSchluessel(x,y):
    return "{0}{1}".format(str(int(round(x,0))).rjust(10,"0"), str(int(round(y,0))).rjust(12,"0"))

I have 2 Fields X = 246715.91 and Y = 4172742.24
After running the above code, I got 0000246716000004172742 (The desired output)
Without int(), I got the same results as yours 00246716.00004172742.0, which is incorrect

A: Your Python code seems valid because when I run:
def AutoSchluessel(gmk, zae, nen):
       return "{}0{}{}".format(gmk, str(zae).rjust(7,"0"), str(nen).rjust(5,"0"))

gmk = 5902
zae = 32
nen = 17

flcode = AutoSchluessel(gmk, zae, nen)

print flcode

it prints out 59020000003200017
If your three input fields are integer then I would expect the same result within the field calculator.
However, if one of those fields is a float or double then I could imagine the points being introduced.

redpajama_set_name: RedPajamaStackExchange


text:
A Million Little Things Season 3 Episode 5: Updates!
Abhijeet Pawar
Hey there! A Million Little Things is an American family drama television series. DJ Nash created this series for ABC. Nash, Aaron Kaplan, Dana Honor, and James Griffiths serve as executive producers on the series. ABC Studios and Kapital Entertainment produced the series.
The series features an ensemble cast including David Giuntoli, Romany Malco, Allison Miller, Christina Moses, Christina Ochoa, Grace Park, James Roday Rodriguez, Stéphanie Szostak, Tristan Byon and Lizzy Greene.
The series received a put pilot commitment at ABC in August 2017. A Million Little Things was ordered to series in May 2018 and premiered on September 26, 2018. In October 2018, the show was picked for a full season of 17 episodes. Later, in February 2019, ABC renewed the series for a second season which premiered on September 26, 2019. In May 2020, ABC renewed the series for a third season which premiered on November 19, 2020.
What is the show about? Will we be having another episode of Season 3? If we are, when is it going to come out? Is it worth watching? Well, you got to keep on reading more to find out! So, let us get started! Here are the answers to your questions!
Also Read: The Falcon and the Winter Soldier: Release Date, Cast and More Updates!
What is the show about?
Set in Boston, a tight-knit circle of friends is shocked after a member of the group unexpectedly dies by suicide. The friends realize that they need to finally start living life as they cope with their loss. The title is a reference to the saying "Friendship isn't a big thing – it's a million little things".
Also Read: The Resident 4: Release Date, Cast and More!
Is A Million Little Things coming back with its Season 3 Episode 5?
A Million Little Things is already back with its Season 3! The first episode aired on 19 November 2020. The latest episode was The Talk which came out on 17 December 2020. We will soon be having another episode coming up. Stay tuned!
Click Here to Visit the Official Site
A Million Little Things Season 3 Episode 5: Official Release Date
Season 3 premiered on 19 November 2020. The next episode, that is the fifth episode, will air on 4 March 2021. Save the date!
Also Read: Disenchantment 3: Release Date, Trailer and More!
A Million Little Things Season 3 Episode 5: Promo
A Million Little Things Season 3 Episode 5: Cast and Characters
We will be seeing David Giuntoli as Eddie Saville, Romany Malco as Rome Howard, and Allison Miller as Maggie Bloom. Also, we have Christina Moses as Regina Howard, Grace Park as Katherine Kim, and James Roday Rodriguez as Gary Mendez. We will also be having Stéphanie Szostak as Delilah Dixon, Tristan Byon as Theo Saville, and Lizzy Greene as Sophie Dixon. Also, we will see Chance Hurstfield as Danny Dixon, Floriana Lima as Darcy, and James Tupper as Andrew Pollock. We have Drea de Matteo as Barbara Nelson, Chris Geere as Jamie, and many others on the show
Related Topics:A Million Little ThingsA Million Little Things Season 3A Million Little Things Season 3 Episode 5ABCAmerican DramaAmerican Television Seriesfamily drama
Snowfall 4: Release Date, Cast and More Updates!
The Falcon and the Winter Soldier: Release Date, Cast and More Updates!


This Silhouette Crystal design sets the standard for playful yet elegant. Polished stainless steel, the black mother-of-pearl dial and Swarovski crystal mark this as a dress watch, while the oversized 32mm case, subdials and water resistance add touches of sportiness to the design. Featuring our Eco-Drive technology – powered by light, any light. Never needs a battery. Caliber number 8635.


Inspire those close to you and your clients with these beautiful greeting cards with your favorite Breyer Horse Model.
How many Collectors do you know who wouldn't love to receive a card like this from you? Perfect for the Holidays or any time of the year because you are able to fill in your own thoughts. Pack of 20.
You won't find these Greeting Cards anywhere else. They are perfect for the Holiday Season and the card is large enough to be framed as an extra gift. Holiday greeting inside.
When you only need one special card for that one special person. Let Halayi help you with your message. High quality cards can also be framed for desk top or hanging.
Here is a perfect way to spread your holiday wishes this Christmas Season. A special card sent from you is sure to help you stand out in the crowd. Available in a package of 20. Holiday greeting inside.
Greeting Cards with the beautiful West Coast Model Horse Jamboree Indian Pony Prairie Song. Blank on the inside so you can add what you would like, making these perfect for all occasions. Your choice of a pack of 10 or 20.
Year of the Horse Breyer model Jade Greeting Card. What a wonderful way to send a special thank you or invitation to those on your list. Perfect for any occasion.Package of 20.
Breyer San Domingo Mustang: single greeting card with a beautiful picture of this ever popular model. Perfect for any occasion with plenty of room for you to write your own personal message.
Wish friends and family a very Merry Christmas with Wintersong! Blank inside for your own personalized greetings. Package of 10.
Clothing, magnets, mousepads and other Breyer Horse Collector gifts from our store.


text:
BEETLEJUICE on Broadway – a real horror
The dead have arrived at the Winter Garden Theatre in this almost dead on arrival so-called musical comedy called BEETLEJUICE based on the 1988 cult favorite movie of the same title by Tim Burton. I am in deep mourning. My love for musical comedy has just been stabbed to death.
BEETLEJUICE left me stunned into silence. It left me with a splitting headache. It left me never wanting to see another film adaptation musicalized.
Musicalized? There isn't even a song list in the Playbill program. That was my first clue. Second clue was that the so-called songs are by Eddie Perfect. In his dreams perhaps he imagines them as being perfect. This score from the same person who inflicted his music and words on that other forgettable horror called KING KONG.
The only song you will remember is THE BANANA BOAT SONG "Day-O" that has not been penned by Mr. Perfect. It is featured in an engagement party scene that boasts a singing boar (as in pig) who is indeed a highlight.
BEETLEJUICE desperately needs a transfusion. Of music. Of lyrics. Some smart humor. As opposed to gross. Full bodied characters. A plot. Instead of flashy (appropriately) tacky costumes (William Ivey Long) a magnificent off-kilter haunted house set (David Korins) blinding lighting effects (Kenneth Posner) and ear piercing sounds masquerading as songs in this insanity foisted upon us by its creators.
For the record – the aforementioned Eddie Perfect (music and lyrics). Scott Brown & Anthony King (book). Brown and King also penned Gutenberg! The Musical! An off-Broadway two character opus where in my review I warned readers to beware of too many exclamation points.
This weird madhouse of cartoon characters and puppets (Michael Curry) and ridiculous goings-on has been directed by that mad-cap director Alex Timbers. Seeking to fill in the missing plot points with whatever sandworm was handy it seems. What choreography there is can be blamed on Connor Gallagher.
Also in mourning is Sophia Anne Caruso as Lydia who deeply misses her recently deceased mom. Dressed in Gothic widow's weeds she wails away at her loss. We soon encounter our narrator and chief mischief maker Alex Brightman as cocaine snorting Beetlejuice incarnate. He of the raspy voice that quickly becomes grating wearing his Jail House Rock striped uniform wishing he could come back to life if only he could find someone alive to say his name three times in a row. I only wanted to say Be Gone! Be Gone! Be Gone! Sorry for the exclamation points.
Alex Brightman is zany, manic, weird, frenzied and freaky and if that's what you like. Go. The production is exhausting, eye-popping and ear drum bursting loud.
The only person to come out alive is the wonderful Leslie Kritzer who makes a silk purse out of that boar's ear with her portrayal of Lydia's soon to be step mom and a dead Senora – Miss Argentina in the second act where production numbers take the place of the gone to the Netherland plot.
For the record Rob McClure and Kerry Butler are wasted away rather quickly as the owners of the house that…it's just too difficult for me to go on…
After the intermission I didn't think it could get any worse. But it did. And it does. Ending with a Game Show contest – Life or Death…the final nail in the coffin.
For the record this inflated nothingness pleased many in attendance.
www.beetlejuicebroadway.com
Photos: Matthew Murphy


text:
New Balance Names Aimé Leon Dore Founder Teddy Santis as Its Newest Creative Director
The streetwear impresario will lead the brand's Made-in-USA sneaker line.
By Demetrius Simms
Demetrius Simms
Demetrius Simms's Most Recent Stories
Saks Fifth Avenue Unveils the Renovated 40,000-Square-Foot Men's Floor at Its NYC Flagship Store
Breitling's Newest Navitimer Pays Tribute to Boeing's Legendary 747 Jumbo Jet
This New Luxe Treehouse Resort in South Africa Will Actually Make Its Own Drinking Water
Courtesy of New Balance
New Balance's Made in USA category has a new made-in-New York leader.
As founder of lifestyle brand Aimé Leon Dore, Teddy Santis has made a name for himself by burnishing American-made products with a decidedly New York sensibility. So, it seems only fitting that the Queens-bred designer was tapped over the weekend to be creative director of New Balance's premium sneaker line.
The Best of Paris's High-Jewelry Collections, From Cartier to Dior
23 Pairs of Unreleased Notorious B.I.G. x Air Jordan 13 Sneakers Are Heading to Auction
The permanent position is the first of its kind for the Boston-based brand, but it's not the first time the two have worked together. Santis has been designing successful streetwear collaborations with New Balance since 2019, including limited-edition collections released through ALD's website and shop in Soho. In his new role, Santis will design his own Made in USA collections, but don't be surprised to see him tinker with traditional staples in the line. After all, he's already put his stamp on the popular 990, and his current New Balance sneaker collabs sell well above retail on the secondary market.
Teddy Santis as the Creative Director of New Balance's MADE in USA line. Courtesy of New Balance
Santis said he took the job because of the company's commitment to authenticity. "I was drawn to New Balance for the way it has built a business founded on values such as integrity and authenticity, rather than passing hype," he said in a statement. "I see a tremendous opportunity to tell authentic stories with real people at the forefront, creating global campaigns that connect our core values with the world."
The designer may be speaking his truth when it comes to telling "authentic stories," but he also knows a thing or two about hype. His most successful ALD campaigns often eschewed big-budget production in favor of featuring local designers and NY rappers, generating the kind of street-level buzz marketing teams can only dream about. It's easy to imagine that homegrown ethos working well at New Balance, a brand that prides itself on its American heritage bona fides—but clearly wants its kicks to be coveted around the world.
Santis's first Made in USA collection will drop in 2022, and if it looks anything like his P550 Basketball Oxford collab last year, it could mark the start of an exciting new era at the brand. Hey, who says New Yorkers and Bostonians can't get along?
Nike Accuses Bape of Ripping Off Its Sneaker Designs
McLaren and APL Just Dropped 3 New Colorways of Their Supercar-Inspired Shoe Collab
Robb Recommends: These Sleek, Comfortable Chelsea Boots Are as Light and Springy as Sneakers
Latest Galleries in Footwear
15 Stylish Pairs of Mules That Don't Look Like House Slippers
11 Great-Looking Pairs of Espadrilles for When Flip-Flips Won't Make the Cut


text:
Matt DeLima Announces Candidacy To Become Walnut Creek California City Councilman
WALNUT CREEK, CA (January 14, 2014) – Citizen entrepreneur Matt DeLima has announced his candidacy for the Walnut Creek, California City Council. DeLima hopes to become a Walnut Creek City Councilman to being a citizen's voice to the body that he sees as out of touch with the common citizen.
DeLima is a local businessman who has spoken out often about what he considers City Council overreach. He has lent his voice to efforts to reign in the city's treatment of local drivers as well as what he sees as a heavy handed approach to local business leaders.
DeLima began his campaign by speaking about his philosophy that the average citizens is the power in an jurisdiction and that elected officials should always be aware of that and never lose touch with the fact that they too were ordinary citizens at one time. DeLima proudly uses the phrase, "A Citizen – Not A Politician" when speaking to groups or campaigning throughout the community and this one slogan reflects his deeper feeling about the role that citizens play in each other's lives.
DeLima often speaks of the fact that he has been able to achieve success in life and in business because of the help he has received from his fellow citizens, and his approach to government is that elected officials should continually work to better the lives of their fellow citizens and help them attain success rather than constantly put up obstacles to success as is often the case with governmental bodies at all levels.
Local residents in Walnut Creek are familiar with DeLima as a successful business owner and many have encountered his "pay-it-forward," citizen-oriented philosophy when they were often on the receiving end of a free cup of coffee while waiting in line behind him. DeLima is also an advocate of volunteerism and can often be found lending his time to local charities, especially those focused on helping disabled veterans in need.
About: DeLima's campaign will center on the issues of lower taxes, less burdensome regulation, promoting volunteerism and implementing policies that allow fellow citizens to help and support each other. DeLima's campaign office will provide further details about the candidate and his positions to those who contact them.
Name: Matt DeLima
Email: marketing.mattdelima@gmail.com
Location: Walnut Creek, CA
Website: http://www.matt-delima.info/


What's better than one awesome book? A whole series! Have a first helping with an extended excerpt of the first in each series, and then go #BackForSeconds with the sequel, because you always have room for more of your favorite series!
Not sure where to start? Take the quiz at the end to find out which sequel to read first.
Want to read them all? Enter the sweepstakes to win a copy of all four sequels!
Read an extended excerpt of This Mortal Coil!
Read an extended excerpt of The Last Magician!
Read an extended excerpt of The Diabolic!
Noah Shaw confesses all in this second novel, following The Becoming of Noah Shaw, of a chilling new companion series to Michelle Hodkin's New York Times bestselling Mara Dyer trilogy!
Read an extended excerpt of The Becoming of Noah Shaw!
Not sure where to start? Take our quiz!
And don't forget to enter the sweepstakes to win a copy of all four sequels!


text:
Winery Visits
Secret Shopper
Southern Oregon Wine Industry Network
DANCIN Vineyard Barbera Alba Presentation
DANCIN Vineyard Barbera Alba presentation to illustrate Building Community with Barbera at DANCIN Vineyards by Chris Cook of Capiche, a wine marketing, public relations (PR), branding, coaching and consulting firm located in the Rogue Valley of Southern Oregon.
Follow Capiche
Chris Cook
Email | Contact
Capiche Conversations: Interview with Terry Brandborg of Brandborg Vineyard & Winery
Following is the inaugural edition of a new series of interviews featuring Capiche clients. We are delighted to introduce Terry Brandborg of Brandborg Vineyard & Winery, based in Elkton, Oregon.
"I have been working and collaborating with Chris Cook of Capiche for several years now. Her professional yet easygoing demeanor makes for a great flow of ideas and top-notch results. The many photo shoots I have done for Chris are always well-planned and thought out to create the best product for her clients. Chris will be an effective and knowledgeable asset for your marketing campaign regardless of the size of your project."
—David Gibb, Photographer, David Gibb Photography
"When I launched Southern Oregon Wine Scene, surrounding myself with the wine industry's most talented writers and industry advocates was at the top of my list. Working closely with Chris at Capiche has proven to be one of the best business decisions ever made! Not only is her writing engaging and interesting, she always beats deadlines and genuinely cares about me and my clients."
—Whitman Parker, Publisher, Southern Oregon Wine Scene/Jacksonville Review
"Chris rocks! If you are looking for a leader who knows Oregon, knows wine and knows marketing, look no further than Chris Cook of Capiche. I have worked with Chris on projects centered on travel and tourism as well as wine education and marketing. She is steady, savvy and fun to work with. As the Oregon wine business booms, we will see new leaders and entrepreneurs stepping up—as we already have with Chris Cook."
—Randy Harrington, PhD, CEO, Strategic Arts & Sciences and Extreme Arts & Sciences/Co-Founder, Best Practices Media
"We are so grateful for the support you have given us and all of the wineries in Southern Oregon. The two of you add to the many who continue to elevate the Southern Oregon wine brand, and we look forward to being a part of that story."
—Doug & Dionne Irvine, Owners, Irvine & Roberts Vineyards
"Thank you for organizing SO WINS (Southern Oregon Wine Industry Network) for 4 years. It was lots of fun and a great way to get to know you and many in the Southern Oregon wine community. Both Nick and I have enjoyed the connections, the contacts, and the sense of community that you have brought to our industry. I know it has taken a lot of effort and commitment on your parts and believe me, it was much appreciated."
—Emily Mostue, Owner, Dunbar Farms and Rocky Knoll Vineyard
"Thank you, Chris, for working with the UVWA Board on the Strategic Marketing Plan. We now have a very organized plan to focus our efforts on moving forward. You have been very patient with our group and I really appreciate your professionalism in moving us through the process. I like your style!"
—Jean Kurtz, Executive Director, Umpqua Valley Winegrowers Association
"We used Capiche to help us redefine our goals and who we are as a company. Chris was instrumental in helping us come together to create a meaningful strategy through a series of five easy and productive sessions. She not only has extensive knowledge of the wine industry but also seamlessly integrated into our team. We are excited to move forward and have her back to check on our progress!"
—Crissie Olson, Owner/Controller, RoxyAnn Winery
"I first met Chris while we were both students at Southern Oregon Wine Institute. Combining that knowledge with her three decades of marketing experience, Chris has become deeply involved in the Southern Oregon wine industry by advising individual wineries and writing for the Southern Oregon Wine Scene and Oregon Wine Press. Marketing is often the winemaker's least favorite part of the job. Chris is uniquely positioned to help wineries to discover and define their brands and to sell that beautiful bottle of wine."
—Kevin Breck, Owner & Winemaker, North Bar Cellars
"Doing a Wine Club Member Survey with Capiche was a very special gift. We got real answers, real information, confirmation about what we were executing correctly and where we needed improvement. I would highly recommend Capiche Marketing & PR. The team was professional and provided information that we could use immediately. Capiche engaged our staff to discuss ideas and work toward the same goals.… We walked away with several ideas—including recommendations and feedback from our very loyal wine club members. I am so pleased. Thank you."
—Porscha Schiller, Former Marketing Director/Tasting Room Manager, South Stage Cellars
"I have been collaborating with Chris Cook on a range of creative projects—publications, websites, marketing collateral, ads, branding, and graphic identity—for a decade. I am always impressed by her clarity of vision, crisp communication style, astute observations and thoughtful guidance. She is a delight to work with, and the process is not only exceptionally effective but also fun!"
—Melissa L. Michaels, President & Creative Director, Michaels & Michaels Creative
"Working with Chris has been very effective. She took the time to get to know us and our business and didn't waste any time making things happen. In an age where marketing opportunities are everywhere, Chris helped to take the guesswork out of which ones would be beneficial to us. In short time, we found ourselves in feature articles and cover stories in targeted publications and on TV—creating a buzz around 2Hawk's change in ownership and quality. This really helped to set the stage as we introduce a new era of quality wines."
—Jen Allen, Owner & Retail Operations Manager, 2Hawk Vineyard & Winery
"One of the best examples of how connected and committed Chris is to the wine industry can best be illustrated by her recent cover story that featured 2Hawk Winery owners Ross and Jen Allen. The story served to not only capture the essence of their personal story but the emerging story of the entire region. Working with a writer and advocate who truly gets the gist of what's happening here is worth its weight in gold medals!"
Capiche Wine Marketing & PR and Capiche © 2021 All Rights Reserved
Website by Michaels & Michaels Creative, LLC | Principal photography by David Gibb Photography


text:
Joint Investigations Team on Lands Inquiry nab Estates and Valuation Officer
Headlines Joint Investigations Team on Lands Inquiry nab Estates and Valuation Officer
editorhttp://www.lusakatimes.com
A Joint Investigations Team on the Ministry of Lands Inquiry has arrested Samuel Daka, an Estates and Valuation Officer at the Ministry of Lands and his wife for Lucy Chalimba for abuse of office and fraud.
And the Investigations Team has also restricted one hundred and eleven (111) properties as a result of inquiries involving officials in the Minstry of Lands pending further investigations.
The Joint Investigations Team comprises officers from the Anti- Corruption Commission (ACC) Drug Enforcement Commission( DEC) and the Zambia Police Service.
According to a statement issued by ACC Public Relations Manager, Tomothy Moono and
made available to ZANIS this evening, in the first count, Daka is charged with falsifying documents contrary to section 344(a) and (D) and 347 of the penal code chapter 87 of the Laws of Zambia.
Details are that on September 19th 2001, Daka jointly and while acting together with
a known person did make a false document namely Chibombo District Council Minute
number SPWD 218/09/2001 purporting to show it was genuine and signed by J. Muteto, Acting Council Secretary for Chibombo District Counci when infact not.
In the second count, Daka is charged with forgery contrary to section 342 and 347 of
the penal code Chapter 87 of the Laws of Zambia.
Details are that on dates unknown, but between September 19 th 2001 and February
23, 2003 jointly and while acting together with a known person, with intent to defraud or deceive did forge one Lands Department application form in the name of Lucy Chalimba purporting to show that it was genuinely recommended and signed by J. Muteto, Chibombo District Council Executive Secretary when in fact not.
In the third count, Daka is charged with uttering false documents contrary to section 352 of the penal code Chapter 87 of the Laws of Zambia.
Details are that on March 20, 2003,knowingly and fraudulently did utter false documents namely Chibombo District Council Minute number SPWD/218/09/2001 and one Lands Department application form in the name of Lucy Chalimba to one Muketoi
Wamunyima, a senior Lands Officer at Ministry of Lands.
In the forth count, Daka and his wife Lucy Chalimba on dates unknown but between
February 23 2003 and March 31, 2003 jointly and while acting together by means of
false pretences , did fradulently procure Mr Banarby Mulenga, Registrar Lands and
Deeds at Ministry of Lands to sign and issue a certificate of title number 45338 for property number F/8905 located in Chibombo District in the name of Easter Senga.
In the fifth count, Daka is charged with abuse of authority of office contrary to section 37(1) (2) (a) and 41 of the Anti Corruption Commission Act number 42 of 1996.
Dates are that on dates unknown but between September 19 2001 and February 23Â 2003, Daka being a person employed in the Public Service namely Ministry of Lands as
Acting Head of Estates and Valuation, unilaterary and without authority , granted
consent to transfer farm number F/8905 to Lucy Chalimba thereby obtaining advantage, a matter or transaction that concerns the Lands in the Ministry of Lands, a public
Mr Moono says the duo have been remanded in custody and will appear in court tomorrow, May 17, 2007.
Previous articleWater consumers in Nkana want only Nkana Water & Sewerage Company
Next articleDelayed salaries contribute to corruption, Police official
MK(Windhoek) May 17, 2007	At	11:41 am
It was just a matter of time. It's expected that many more will follow suit. We saw these ' boys' join MOL after graduating from CBU. Within just a few years they had amassed a lot of assets in unexplained circumstances. MOL was turned into a money spinner for them and this was done with impunity. State land was in certain cases subdivided and sold at break-neck prices – in millions of kwacha e.g. the land designated for the Civil Servants Recreation Club in the Mass Media area.
I for one propose that all the ill-gotten land at the hands of these 'boys' and 'girls' be forfeited back to the state. As for the culprits, they should be prosecuted to the full extent of the law.
FKC(Atlanta) May 21, 2007	At	2:05 pm
You are right MK. I know some of the MOL guys from CBU and it is suprising how much wealth they have amassed in such a short time. You guys at VD ie late CM, BBC and others were real professionals. Suprisingly, most of the CBU guys were recruited in Chiluba's regime. Is it mere coincidence?
Headlines Chief Editor - January 16, 2021 70
The Zambian government has awarded a six month contract to a UK consultancy to help manage communications regarding the country's debt restructuring process. Highgate Advisory...
Only K29, 448.36 is still owed by Former Ministers who over stayed in Office-Accountant General
The Ministry of Finance has said that a total of K4, 266, 664.10 has been refunded by owing Ministers that stayed in office after...
Schools Opening to be delayed by two weeks-President Lungu
President Edgar Lungu has announced, with caution, that the reopening of schools, slated for Monday, 18th January 2021, will be delayed for two weeks...
Davies Mwila orders PF members not to issue any statement on Pay back Money for Former Ministers
The Patriotic Front (PF) leadership has insisted that well-wishers within the party settled the Four-point Seven million Kwacha bill for the former ministers who...


CCTV preps mobile IP-based field production system for large-scale sports coverage.
Rastatt, Germany (February 8, 2018)—State broadcaster CCTV has launched the first mobile IP-based audio electronic field production (EFP) system in China, having commissioned a setup based around mc² mixing consoles from Lawo with RAVENNA real-time audio transport.
The project is the latest in a longstanding relationship between NDT and CCTV, which serves an audience of over one billion people via 45 TV and radio channels. The move into mobile IP-based audio is intended to enhance CCTV's capabilities for dedicated audio production and broadcast in sports and music programming, especially for large-scale sports coverage.
NDT designed the system using a typical spine-leaf IP switch network, with two Cisco 3850 switches acting as main and backup respectively. A further six Cisco 2960 switches provide main and backup support for three remote stage-boxes on one system. NDT also provided global surveillance software to monitor the status of the PTP master clock and log files of the switches.
CCTV has been using Lawo mixing consoles since 2008, and has seven studios equipped with mc²66 desks plus a small audio OB van outfitted with a Lawo mc²56 console. The new installation of Lawo mc² consoles will bring full IP configuration to CCTV for the first time.


text:
Biografia

Inizi
René Blum nasce a Parigi. All'inizio del secolo è collaboratore del giornale letterario parigino Gil Blas e affermato critico teatrale. Durante la Prima Guerra Mondiale Blum combatte nella battaglia della Somme. Contribuisce a mettere in salvo capolavori minacciati dalle operazioni belliche nella cattedrale di Amiens e per questo viene insignito con la croce di guerra francese.

Montecarlo
Diventa direttore teatrale e di operetta a Montecarlo nel 1924, presso i Balletti Russi di Sergej Diaghilev. Nel 1931, Blum viene incaricato da Luigi II Principe di Monaco allo scopo di creare una compagnia di balletto che continui il lavoro di Diaghilev (morto nel 1929). Nel 1932, con il sostegno del finanziere Serge Denham, Blum e il Colonnello W. de Basil fondano la compagnia Ballet Russe de Monte Carlo.

Blum e de Basil fanno fallimento nel 1934, e il Balletto Russo si scioglie. Tuttavia Blum continua a mantenere vivo il balletto a Montecarlo: ingaggia dapprima la ballerina e coreografa Bronislava Nijinska, e dopo di lei Michel Fokine. Nel 1937 Blum e l'ex coreografo dei Balletti Russi Léonide Massine ottengono finanziamenti da Julius Fleischmann Jr. per creare una nuova compagnia. Nel 1938 la nuova compagnia riprende il nome di "Balletto Russo di Montecarlo", anche se allo scoppio della guerra, nel 1939, si trasferisce definitivamente a New York. La compagnia rimasta a Montecarlo prenderà poi il nome di Nuovi Balletti di Montecarlo nel 1985.

Deportazione e morte
Nell'estate del 1940, dopo l'occupazione tedesca di Parigi, Blum ritorna in Francia per stare vicino alla famiglia. È tra i primi ebrei francesi a essere arrestati dalla polizia francese, il 12 dicembre 1941 nella sua casa di Parigi. Viene portato nel campo di internamento di Beaune-la-Rolande, poi in quello di Drancy. Il 23 settembre 1942 viene trasferito ad Auschwitz. Durante la prigionia è noto fra i compagni per i suoi racconti di vita artistica che contribuiscono a sollevare il morale. Viene ucciso dai nazisti a fine settembre 1942 all'età di 64 anni.

Note

Altri progetti

Collegamenti esterni

Ebrei francesi
Morti nel campo di concentramento di Auschwitz
Balletto

redpajama_set_name: RedPajamaWikipedia


Juliette Binoche and André Benjamin have joined the cast of Claire Denis' "High Life," Variety has learned.
The film revolves around convicts who reduce their time behind bars in exchange for embarking on a dangerous mission to a black hole. Robert Pattinson and Mia Goth were already announced as star rig in the film. In addition, Variety has learned that the cast has added Lars Eidinger ("Clouds of Sils Maria"), Agata Buzek ("Redemption"), Ewan Mitchell ("The Last Kingdom"), Jessie Ross ("The Frankenstein Chronicles") and Claire Tran ("Valerian and the City of a Thousand Planets").
Principal photography will take place in Cologne, Germany. Denis has tapped visual artist Olafur Eliasson to design of the black hole. The original score and sound design comes from her long-time musical collaborator, Stuart Staples. Scientific expertise has been provided by the astrophysicist Aurélien Barrau, as well as the European Space Agency.
Andrew Lauren Productions (ALP) is financing the film and is partnering with Alcatraz Films (Paris), Pandora Film Produktion (Cologne), The Apocalypse Films (London), and Madants (Warsaw) to produce High Life. Andrew Lauren and partner D.J. Gugenheim will produce for ALP, Laurence Clerc & Olivier Thery-Lapiney for Alcatraz, Claudia Steffen & Christoph Friedel for Pandora, and Oliver Dungey for Apocalypse. Klaudia Smieja will co-produce for Madants.
Binoche is represented by Intertalent, Untitled Entertainment, CAA and Artmedia. Benjamin is represented by WME. Buzek is represented by Coolkeyplay and European Talent Network. Mitchell is represented by Independent Talent Group. Tran is represented by Independent Talent Group and Agence Adequat.
The film is supported by Film and Medienstiftung NRW, Medienboard Berlin-Brandenburg, Filmförderungsanstalt, ZDF/ARTE and DFFF in Germany, Arte France Cinema, CNC and Canal+ in France, the BFI, awarding funds from the National Lottery, in the United Kingdom and by the Polish Film Institute in Poland. It was developed with the support of Altaris Partners and the British Film Institute in the United Kingdom and with Medien- und Filmstiftung NRW in Germany.
Wild Bunch is handling international sales while CAA will handle the domestic sale.