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Justia Patents US Patent Application for FASTENER APPLICATOR WITH INTERLOCK Patent Application (Application #20200038025)
FASTENER APPLICATOR WITH INTERLOCK
Oct 11, 2019 - DATASCOPE CORP.
The present disclosure relates to a fastener applicator including a handle, a first trigger coupled rotatably with respect to the handle, and a second trigger coupled rotatably with respect to the handle. An interlock is disposed with the second trigger and comprises a cam follower engaged in a cam channel that selectively prevents rotation of the second trigger relative to the first trigger depending on a location of the cam follower within the cam channel. The location of the cam follower in the cam channel is set by a position of the first trigger. Methods of operating the various embodiments disclosed are also provided.
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This application claims the benefit of priority to provisional U.S. Patent Application Ser. No. 61/906,290 filed Nov. 19, 2013, hereby incorporated by reference in its entirety.
FIELD OF THE DISCLOSURE
The present disclosure pertains broadly to the field of fasteners and/or applicators. More specifically, the disclosure relates to surgical applicators of implants and/or fasteners, including but not limited to sterilized fasteners such as staples.
Atrial fibrillation is a relatively common condition characterized by a very rapid heartbeat of the left and right atrium. While atrial fibrillation is not normally fatal itself, it has been associated with an increased risk of stroke. It is believed that the rapid heartbeat causes blood to pool in the left atrial appendage which causes emboli that are released into the left atrium from where they can enter the cerebral vasculature, thus causing a stroke. In addition to stroke, the emboli can enter coronary circulation, potentially causing myocardial infarction, or can enter peripheral circulation, potentially causing peripheral vascular disease.
The risk of stroke in patients suffering from atrial fibrillation can be reduced in a variety of ways. For example, blood thinning drugs can be used to reduce the risk of clot formation. The use of blood thinners, however, is contraindicated in patients at risk of bleeding disorders. More aggressive treatment protocols have been proposed which involve closing the left atrial appendage. Closure and excision may be performed in open surgical procedures, typically requiring the patient to be placed on by-pass and the chest to be opened through the sternum. Alternatively, thoracoscopic and other less invasive procedures have been proposed. U.S. Pat. No. 5,306,234 teaches the performance of beating heart procedures using otherwise conventional surgical techniques. The use of conventional techniques through small chest penetrations while the heart is beating can be difficult to perform. U.S. Pat. No. 5,865,791 describes an intravascular approach where tools are introduced through the vasculature and passed into the left atrium. The tools are used to ablate or fuse the left atrial appendage from the inside using energy, adhesives, or the like. The '791 patent also describes a thoracoscopic procedure where a tether is placed over the neck of the atrial appendage and tied off to achieve isolation. The '791 patent still further suggests other closure elements including sutures, staples, shape-memory wires, biocompatible adhesives, and the like. U.S. Pat. No. 6,488,689 describes a transpericardial procedure where the distal tip of the left atrial appendage is grasped and pulled backwardly through a capture loop which encircles the base of the left atrial appendage.
A compliant closure structure for the sealing bodily structures such as the left atrial appendage is described in co-pending, commonly owned U.S. Patent Publication 2007/0260278 (application Ser. No. 11/744,135), the full disclosure of which is incorporated herein by reference in its entirety. The compliant structure described in the '278 publication comprises an elastomeric body having a pair of opposed legs which may be arranged in an oval or a U-shaped configuration to define an opening therebetween. By placing the opening between the legs over the left atrial appendage and aligning it with the base of the appendage, the structure may be closed to provide the desired sealing. To hold the structure closed, a number of discrete, axially spaced-apart tissue penetrating fasteners are arranged along the lengths of each of the legs. By compressing the legs together to press-fit the closure devices, the compliant structure may be closed to provide a compliant seal which effectively isolates the left atrial appendage.
The '278 publication describes a particular delivery tool for the compliant closure structure. The delivery tool includes jaws which can be inserted into the legs of the closure structure and actuated to close the jaws in the legs over the left atrial appendage. The jaws further include comb studs which engage and press fit the closure devices in order to hold the compliant structure in its closed, sealing configuration. The studs are intended to be retracted to allow the delivery tool to be removed.
Although functional, the delivery tool of the '278 publication has certain shortcomings. For example, the actuation of the jaws and retraction of the comb studs can be performed out of order, increasing the risk that the delivery of the compliant structure will fail. Moreover, positioning and orientation of the delivery tool can be difficult, particularly when the tool is introduced through an intercostal penetration to access the left atrium. Additionally, the jaws in the device of the '278 publication are attached in the axial plane of the device shaft. Such a straight line of attachment can make it more difficult to align the jaws with the base of the appendage and across the os (i.e., ostium) of the atrium leading into the appendage. If the closure device is not aligned across the base to completely close the os, gaps or openings (referred to as "cul-de-sacs") can remain at the site of closure, increasing the risk of thrombus formation in the atrium. The importance of forming a complete seal of the os which is free from such cul-de-sacs is discussed in Salzberg et al. (2008) Eur. J. Cardiothoracic Surg. 34:766-770.
For these reasons, it would be desirable to provide improved delivery tools for use with the tissue closure devices described in U.S. Patent Publication 2007/0260278. It would be further desirable if the delivery tools and methods of their use were compatible with the delivery of other tissue closure devices and for procedures in addition to closure of the left atrial appendage.
A surgical applicator for a fastener according to an example embodiment comprises a handle, a first trigger coupled movably with respect to the handle, and a second trigger coupled movably with respect to the first trigger, but operatively arranged to move in tandem with the first trigger during movement of the first trigger. An interlock is coupled to the second trigger and operatively arranged to selectively prevent movement of the second trigger relative to the first trigger depending on a position of the first trigger with respect to the handle.
According to an example embodiment, the interlock permits movement of the second trigger relative to the first trigger when the first trigger is moved from a first position to a second position, and restricts movement of the second trigger relative to the first trigger when the first trigger is not in the second position.
According to an example embodiment, a second interlock is coupled to the first trigger and operatively arranged to selectively prevent movement of the first trigger relative to the handle depending on a position of second trigger.
According to an example embodiment, a jaw assembly is selectively opened and closed via movement of the first trigger.
According to an example embodiment, movement of the second trigger selectively retracts one or more fastener supporting structures of the jaw assembly with respect to at least one jaw of the jaw assembly.
According to an example embodiment, the interlock includes a cam follower engaged with a cam channel.
According to an example embodiment, the handle includes the cam channel and the second trigger includes the cam follower.
According to an example embodiment, the cam channel has a first leg that permits tandem movement of the second trigger with the first trigger during closing of the first trigger and a shoulder that prevents movement of the second trigger relative to the first trigger until the first trigger is closed.
According to an example embodiment, the cam channel has a second leg that permits tandem movement of the second trigger with the first trigger during re-opening of the first trigger after the second trigger has been closed relative to the first trigger.
According to an example embodiment, the cam channel includes at least one leg formed concentrically with respect to a first pivot about which the first trigger is rotatably coupled to the handle and a transverse portion formed concentrically with respect to a second pivot about which the second trigger is rotatably coupled to the first trigger.
According to an example embodiment, the at least one leg includes two legs, and the transverse portion is connected between the two legs.
A fastener applicator according to an example embodiment comprises a handle, a first trigger coupled rotatably with respect to the handle, and a second trigger coupled rotatably with respect to the handle. An interlock is disposed with the second trigger and comprises a cam follower engaged in a cam channel that selectively prevents rotation of the second trigger relative to the first trigger depending on a location of the cam follower within the cam channel. The location of the cam follower in the cam channel is set by a position of the first trigger.
A fastener applicator according to an example embodiment comprises a handle, a shaft extending distally from the handle and a jaw assembly at a distal end of the shaft having one or more fastener supporting structures. A first trigger is coupled movably with respect to the handle and to the jaw assembly such that movement of the first trigger relative to the handle selectively closes the jaw assembly. A second trigger is coupled movably with respect to the first trigger, the second trigger coupled to the jaw assembly such that movement of the second trigger relative to the first trigger selectively retracts the one or more fastener supporting structures; and an interlock coupled to the second trigger and operatively arranged to selectively prevent movement of the second trigger relative to the first trigger depending on a position of the first trigger.
According to an example embodiment, the interlock permits movement of the second trigger relative to the first trigger when the first trigger is closed and prevents movement of the second trigger relative to the first trigger when the first trigger is open.
According to an example embodiment, the second trigger is movable in tandem with the first trigger during movement of the first trigger.
A fastener applicator according to an example embodiment comprises a handle, a first trigger movable with respect to the handle between a first position and a second position, and a second trigger movable with respect to the first trigger between an initial position and an actuated position. A first interlock is coupled to the second trigger and operatively arranged to selectively prevent movement of the second trigger relative to the first trigger until the first trigger is moved into the second position. A second interlock is coupled to the first trigger and operatively arranged to selectively prevent movement of the first trigger relative to the handle until the second trigger is moved into the actuated position.
According to an example embodiment, a pair of jaws is included, with the first trigger coupled to the pair of jaws for setting the pair of jaws in an open configuration when the first trigger is in the first position and in a closed configuration when the first trigger is in the second position.
According to an example embodiment, one or more fastener supporting structures are disposed with the pair of jaws. The second trigger is coupled to the one or more fastener supporting structures for setting the one or more fastener supporting structures in a deployed configuration when the second trigger is in the initial position and in a retracted configuration when the second trigger is in the actuated position.
A method of operating a fastener applicator according to an example embodiment comprises: (i) repositioning a first trigger of the fastener applicator with respect to a handle from a first position to a second position, (ii) moving a second trigger in tandem with the first trigger, (iii) preventing repositioning of a second trigger between an initial position and an actuated position relative to the first trigger with an interlock coupled to the second trigger until the first trigger is moved to the second position, and (iv) repositioning the second trigger to the actuated position relative to the first trigger after the first trigger is moved to the second position.
A method of operating a fastener applicator according to an example embodiment comprises: (i) moving a first trigger of the fastener applicator with respect to a handle from a first position to a second position, (ii) preventing movement of a second trigger between an initial position and an actuated position relative to the first trigger with an interlock coupled to the second trigger until the first trigger is moved to the second position, (iii) rearranging a cam follower and a cam channel of the interlock with respect to each other due to the moving of the first trigger to the second position, and (iv) moving the second trigger to the actuated position relative to the first trigger after the first trigger is moved to the second position.
A method of operating a fastener applicator according to an example embodiment comprises: (i) moving a first trigger of the fastener applicator with respect to a handle from a first position to a second position, (ii) preventing movement of a second trigger between an initial position and an actuated position relative to the first trigger with a first interlock coupled to the second trigger until the first trigger is moved to the second position, (iii) moving the second trigger to the actuated position relative to the first trigger after the first trigger is moved to the second position, (iv) preventing movement of the first trigger relative to the handle back to the first position with a second interlock coupled to the first trigger until the second trigger is moved to the actuated position, and (v) moving the first trigger back to the first position relative to the handle after the second trigger is moved to the actuated position.
A method of operating a fastener applicator according to an example embodiment comprises: (i) repositioning a first trigger of the fastener applicator with respect to a handle from a first position to a second position, (ii) closing a jaw assembly coupled to the handle of the fastener applicator due to movement of the first trigger to the second position, (iii) preventing repositioning of a second trigger between an initial position and an actuated position relative to the first trigger with an interlock coupled to the second trigger until the first trigger is moved to the second position, (iv) repositioning the second trigger to the actuated position relative to the first trigger after the first trigger is moved to the second position, and (v) retracting one or more fastener supporting structures comprising at least one protrusion movably extendable and retractable with respect to at least one jaw of the jaw assembly of the fastener applicator due to repositioning of the second trigger to the actuated position.
According to an example embodiment, the fastener applicator comprises a second interlock coupled to the first trigger and the method further comprises preventing movement of the first trigger from the second position to the first position with the second interlock until the second trigger is moved to the actuated position relative to the first trigger, and repositioning the first trigger from the second position back to the first position after the second trigger is moved to the actuated position relative to the first trigger.
According to an example embodiment, rotating the first trigger from the first position to the second position includes traversing the cam follower along a first leg of the channel.
According to an example embodiment, the first leg is formed concentrically with respect to a pivot about which the first trigger rotates.
According to an example embodiment, rotating the second trigger to the actuated position relative to the first trigger includes traversing the cam follower along a portion of the channel transverse to the first leg.
According to an example embodiment, rotating the first trigger from the first position to the second position including moving the second trigger in tandem with the first trigger.
The following descriptions should not be considered limiting in any way. With reference to the accompanying drawings, like elements are numbered alike:
FIG. 1 is a perspective view of a closure device applicator constructed in accordance with to an example embodiment of the present disclosure;
FIG. 2 is a partial cross-sectional elevation view of the closure device applicator of FIG. 1, shown with the jaws open and rotated 90° relative to the position shown in FIG. 1;
FIG. 3 is a partial, cross-sectional elevation view of the device applicator similar to FIG. 2, shown with the first trigger closed relative to the handle in order to close the jaws, and the second trigger open (or spaced apart) with respect to the first trigger;
FIG. 4 is a partial, cross-sectional elevation view of the closure device applicator similar to that shown in FIGS. 2 and 3 with the second trigger closed relative to the first trigger demonstrating a retraction of the closure device-engaging studs;
FIG. 5 is a partial, cross-sectional elevation view of the closure device applicator of FIGS. 2-4, shown with the first trigger re-opened with respect to the handle in order to open the jaws while the closure device-engaging studs remain retracted;
FIG. 6A-6D illustrate the movement of the jaw and stud engagement with the closure devices of a tissue closure device according to an example embodiment of the present disclosure;
FIG. 7 illustrates an exemplary mechanism by which the closure device-engaging studs are retracted within the jaws according to an example embodiment of the present disclosure;
FIG. 8 illustrates an interlock formed between a cam channel, slot, or groove in a handle of the applicator of FIG. 1, shown in cross-section, and a cam follower projecting from a second trigger of the applicator of FIG. 1, shown in a perspective and exploded view orientation according to an embodiment of the present disclosure;
FIGS. 9A-9E illustrate various positions of the cam follower of FIG. 8 along the cam channel of the interlock as first and second triggers of the applicator are moved through the configurations depicted in FIGS. 2-5;
FIG. 10 illustrates operation of the interlock of FIG. 8 with respect to the first and second triggers of the applicator of FIG. 1; and
FIG. 11 illustrates use of the applicator according to an example embodiment of the present disclosure, wherein the applicator is used for closing a closure device over a left atrial appendage.
A detailed description of one or more embodiments of the disclosed apparatus and method are presented herein by way of exemplification and not limitation with reference to the Figures.
Embodiments of the present disclosure provide alternative and improved apparatuses, systems, and methods for deploying one or more closure devices or fasteners to tissue. An exemplary tissue structure of a patient at risk of stroke or other adverse events resulting from emboli released into circulation from the left atrial appendage, may include the left atrial appendage. Patients benefiting from the exemplary procedures disclosed herein will at least partially include those suffering from atrial fibrillation which can cause clot and thrombus formation in the left atrial appendage, thus increasing the chance of emboli release.
Exemplary embodiments of the present disclosure provide a mechanical closure device applicator for introducing the fastener over the tissue structure, which fastener is left in place in order to close and/or seal the tissue structure. A portion of the tissue structure extending beyond the fastener may then be cut, excised, or otherwise removed, although this may be left to the physician's preference. In one embodiment, the tissue fastener comprises a compression body having at least two opposed, compliant tissue-engaging surfaces which are placed over opposite sides of the tissue structure. In this embodiment, the tissue-engaging surfaces are held together by a plurality of axially spaced-apart tissue-penetrating fasteners, which extend from one of the surfaces, through the intermediate tissue, and into the other surface to both hold the compression body in place and to apply a desired level of compression force, which is determined by both the softness of the compression body and the distance between the surfaces when they are fully attached. A well may be provided in the compression body around the tissue-penetrating barb of the fastener such that a gasket seal is formed by the compression body around the puncture site in the tissue. A stabilizing lip may be provided in one leg of the compression body to prevent a rolling motion of one leg with respect to another leg of the compression body in order to keep the two opposing soft members linearly aligned. More detailed descriptions of fasteners suitable for use with embodiments of the present disclosure are found in patent publication U.S. 2007/0260278, the full disclosure of which has been previously incorporated herein by reference.
Referring now to FIG. 1, a fastener applicator 10 constructed in accordance with various embodiments of the present disclosure comprises a shaft 12 having a handle assembly 14 at its proximal end, and a jaw assembly 16 at a distal end, where individual jaws 18 and 20 are adapted to carry a fastener 22, as best illustrated in FIGS. 6A-6D. The fastener 22 is shown in an example embodiment to have a IJ-shaped configuration which defines a V-shaped region 24 for receiving the left atrial appendage or other tissue structure when the jaws are open as shown in FIGS. 1, 2, and 6A. A plurality of studs 26 are formed along the inner surfaces of each jaw 20 and 18 to engage tissue-penetrating fasteners which comprise penetrating components 28 and receptacle components 30, as best shown in FIG. 6A. The handle assembly 14 will include a handle 32, a first trigger 34, and a second trigger 36.
Referring now to FIGS. 2 and 6A, the fastener applicator 10 is shown in its shelf or delivery configuration with the fastener 22 received over the jaw assembly 16 and the V-shaped opening 24 in the device ready to be placed over a tissue structure such as the left atrial appendage (see FIG. 10). The triggers 34 and 36 are each respectively movable between an initial or first position and an actuated or second position. As will be discussed in more detail below, the first trigger 34 is movable between its respective positions relative to the handle 32, while the second trigger 36 is movable between its respective positions relative to the first trigger 34. In one embodiment, in their respective first positions, the first trigger 34 and the second trigger 36 are initially in a fully open position, that is, pivoted fully away from the handle 32. For this reason, it is to be understood that any mention of "opening" the first trigger 34 refers more generally to moving the first trigger 34 toward its first or initial position, while any mention of "closing" the first trigger 34 or the second trigger 36 refers more generally to moving the first trigger 34 or the second trigger 36 towards its respective second or actuated position.
After the fastener 22 is advanced over the left atrial appendage or other target tissue structure, the jaws 18 and 20 are closed by manually pulling the first trigger 34 toward the handle 32, as shown in FIGS. 3 and 6B. The first trigger 34 is mounted on a pin or pivot 40, which is shown to be fixedly secured to the handle assembly 14, thereby rotatably coupling the first trigger 34 to the handle 32. Closing the first trigger 34 with respect to the handle 32, that is, pivoting about the pivot 40 from the first position of the first trigger 34 to the second position, proximally retracts the rod 42 which is linked to the first trigger 34 by a pin or pivot 41 and a lever 43. The rod 42 is attached to a pin 44 (FIG. 6B) which is pivotally attached to the proximal ends of the jaws 18 and 20 and proximally retracts the jaws so that they are closed by the movement of slots 46 over pins 48 in an end frame 50 attached to a stationary sleeve 52. When the jaws 18 and 20 are closed, the studs 26 engage the tissue penetrating components 28 and the tissue penetrating receptacles 30 so that they engage and lock with each other, thus closing the two legs of the fastener 22, as shown in FIG. 6B.
The second trigger 36 may be mounted on the pin 41 so that the second trigger 36 moves, actuates, or closes with respect to the handle 32 in tandem with the first trigger 34. In this way, the second trigger 36 is rotatably coupled to the handle 32, although indirectly via the pin 41 and the first trigger 34. By "in tandem" it is meant that movement of the first trigger 34 translates at least partially into corresponding movement of all or portions of the second trigger 36. In the illustrated embodiment, movement of the first trigger 34 causes a substantially equivalent amount of rotational movement of the second trigger 36, although there could be gears, linkages, springs, or the like to cause a lesser or greater degree of movement of the second trigger 36 to result from corresponding movement of the first trigger 34.
The applicator 10 may optionally include an interlock 60 in some embodiments. According to the illustrated embodiment, as the first trigger 34 and the second trigger 36 are moved in tandem, a ratcheting tooth surface 62 of the interlock 60 is closed against pins 64, as shown in FIG. 3, so that the first trigger 34 cannot be re-opened once the jaw assembly 16 has been closed, either completely or to a certain degree of closure or spacing between the jaws. This is advantageous as described above, since the jaws should not be completely opened prior to retracting the studs 26 by closing the second trigger 36, as will be described below. The ratcheting tooth surface 62 can include any number of ratchets or notches such that the first trigger 34 can be progressively closed (i.e., brought into approximation of the handle 32) by more fully driving the ratcheting tooth surface 62 along the pins 64 in the direction of closure for the first trigger 34 (e.g., from the configuration of FIG. 2 to the configuration of FIG. 3).
Additionally, as the first trigger 34 is moved to its actuated, closed, or second position (i.e., moved or actuated to the configuration of FIG. 3) in order to close the jaws 18 and 20 of the jaw assembly 16, a corner 66 (see FIG. 2) of the interlock 60 will engage an inclined surface 68 on a clicker pin 70 to disengage the clicker pin 70 from a holding pin 72, thus allowing a spring 74 to push the pin 70 downward so that a bottom surface 76 thereof strikes the bottom of the handle 32, thus causing a loud click to audibly alert the physician that the jaws have been closed and the interlock 60 has been engaged. This audible confirmation indicates to the physician or other medical personnel that the fastener 22 has been closed and that the studs 26 can be retracted.
The studs 26 are initially in an extended configuration, as shown in FIGS. 2-3 and 6A-6B, and then retracted by closing second trigger 36 against the first trigger 34, as shown in FIGS. 4 and 6C. Closure of the second trigger 36 relative to the first trigger 34 draws the outer sleeve 54 proximally over the stationary sleeve 52 which draws pull wires 80 proximally to pull stud combs 84 or other fastener supporting structures, proximally, as shown in FIG. 7. The stud combs 84 are mounted on pins 86 which travel in slots 88 formed in each of the jaws 18 and 20. The second trigger 36 is pivotally mounted on, or rotatably coupled to, the first trigger 34 by the pin 41 and is coupled to the stationary sleeve by pins 90 and 91 and a lever 92. It is to be appreciated that the studs 26 can take other shapes or arrangements and/or that other fastener supporting structures (i.e., structures capable of supporting the fasteners 22 during closing and engaging thereof) can be included in lieu of the studs 26 that are either disengaged from or engaged to the fastener 22 upon intentional closure or movement of the second trigger 36. For example, in lieu of a plurality of individual studs 26, a supporting structure in the form of a single unitary rail supporting all of the components 28 can be included in one embodiment.
Movement of the second trigger 36 relative to the first trigger 34, e.g., closure of the second trigger 36, disengages the interlock 60 by engaging a ramped surface 94 attached to the interlock 60 against a fixed pin 96 in the second trigger 36. In this way, the interlock 60 selectively permits or prevents movement, e.g., opening, of the first trigger 34 depending on a position of the second trigger 36. In other words, movement of the second trigger 36 to its corresponding second position, relative to the first trigger 34, releases the interlock 60. The pin 96 follows the path shown in broken line in FIG. 3 to engage the surface 94. The ramped surface 94 is caused to move downwardly, pulling the ratchet teeth 62 away from the fixed pins 64, as shown in FIGS. 4 and 5. The triggers 34 and 36 are now ready to be opened in order to open the jaws, as will now be described.
Referring now to FIGS. 5 and 7C, the jaws 18 and 20 may be opened by releasing manual compression on the first and second triggers 34 and 36, allowing spring 98 which was compressed during closure of the first trigger 34 to push rod 42 (attached to pivot 44) distally forward, opening the jaws and leaving the fastener 22 in place.
FIG. 8 shows a cross-section of the handle 32 as well as the second trigger 36 exploded therefrom. An interlock 100 is included between the handle 32 and the second trigger 36 to selectively permit and prevent rotational movement of the second trigger 36 with respect to the first trigger 34. The first trigger 34 does not form a part of the interlock 100 in the illustrated embodiment, and therefore is not illustrated in FIG. 8. However, it is to be understood that the first trigger 34 in the embodiment of FIG. 8 would be nevertheless be secured to the second trigger 36 at the pivot 41 as described herein with respect to the other Figures. Additionally, the shaft 12 and the jaw assembly 16 are not illustrated in some Figures, including FIG. 8, but can be included as described herein with respect to the other Figures.
More specifically, the interlock 100 includes a cam follower 102 and a channel 104. In the illustrated embodiment, the cam follower 102 is formed as a protrusion or projection extending from or otherwise coupled to the second trigger 36, and is preferably round in cross section but alternatively may be of other shapes. The cam follower 102 can be integrally formed with the second trigger 36 or affixed thereto as a separate component. The channel 104 may be formed as a groove, depression, notch, slot, or the like in the handle 32. The follower 102 is configured to engage with and/or travel along the channel 104 (and thus will be restricted to movement within the channel 104) when the second trigger 36 is assembled with the handle 32. It is noted that the applicator 10 can include other exemplary embodiments of a single follower 102 and a single channel 104 if desired, but for symmetry, balance, etc., the second trigger 36 may include two cam followers 102 (e.g., another follower 102 hidden from view in FIG. 8 on the opposite lateral side of the second trigger 36 and mirroring the illustrated one of the followers 102 about a plane bisecting the second trigger 36), and the handle 32 may correspondingly include two cam grooves 104 (e.g., another channel 104 located in the half of the handle 32 not shown in FIG. 8, which mirrors the illustrated channel 104 about the plane used to form the cross-sectional view of the handle 32 in FIG. 8).
The mechanical coupling of the follower 102 to the second trigger 36 prevents rotation of the second trigger 36 relative to the first trigger 34 when the follower 102 abuts against the walls or shoulders defining the channel 104. For example, FIGS. 9A-9E show various positions of the follower 102 (without the second trigger 36 for clarity) corresponding to the various combinations of positions of the first and second triggers 34 and 36 of the applicator 10. That is, for example, the position of the follower 102 in FIG. 9A corresponds to an initial, shelf, or delivery configuration of the applicator 10 shown in FIG. 2, i.e., before the triggers 34 or 36 have been actuated.
In the position of FIG. 9A, rotation of the second trigger 36 is prevented by interference of the follower 102 with a shoulder 106 of the channel 104. That is, movement of the second trigger 36 relative to the first trigger 34 occurs about the pin 41, which rotationally couples the second trigger 36 to the first trigger 34. Thus, rotation of the second trigger 36 about the pin 41 (if unblocked) would result in the cam follower 102 following an arc defined by a circular path concentric with the pin 41, e.g., illustrated as a circle 107 in FIG. 10. From FIG. 10, it is clear that rotational movement of the cam follower 102 along an arc defined by the circle 107 is not possible due to interference between the cam follower 102 and the shoulder 106. Accordingly, rotation of the second trigger 36 about the pin 41 relative to the first trigger 34 is prevented by the interference between the cam follower 102 and the shoulder 106.
The channel 104 is shaped with a leg 108, which permits the second trigger 36 to travel in tandem with the first trigger 34 as the first trigger 34 is moved toward its second position, i.e., rotated about the pivot 40 toward the configuration of the applicator 10 shown in FIG. 3. That is, again referring to FIG. 10, tandem movement of second trigger 36 due to movement of the first trigger 34 would result in the cam follower 102 traveling along an arc defined by a circular path concentric with the pivot 40, illustrated in FIG. 10 by a circle 109. The first leg 108 is arranged to lie substantially along such an arc formed by the circle 109, thereby enabling the cam follower 102 to travel along the leg 108 during rotation of the first and second triggers 34 and 36 about the pin 40.
FIG. 9B illustrates the position of the follower 102 in the channel 104 when the first trigger 34 is rotated partially toward the configuration of FIG. 3, e.g., with ratcheting tooth surface 62 of the interlock 60 at most only partially driven along and engaged with the pins 64. At the position of FIG. 9B, the shoulder 106 continues to prevent rotation of the second trigger 36 by blocking movement of the follower 104 in the direction necessary to rotate the second trigger 36.
FIG. 9C illustrates the position of the follower 102 after the trigger first 34 has been moved to the configuration of FIG. 3 and the ratcheting tooth surface 62 of the interlock 60 is fully driven along and engaged with the pins 64. It can be appreciated in view of FIGS. 3 and 9C that rotation of the second trigger 36 becomes possible at this position because the shoulder 106 no longer abuts the follower 102. Alternatively stated, it is to be appreciated that tandem movement of the second trigger 36 with the first trigger 34 has shifted the position of the cam follower 102 and the pin 41 relative to the channel 104 (since the pin 41 and the cam follower 102 are directly coupled to the second trigger 36 in the illustrated embodiment). It is to be further understood that this shifting of the position of the pin 41 and the cam follower 102 has also moved the location of the circle 107 to align with a portion 110 of the channel 104 that is transverse to the leg 108 and arranged along an arc that is concentric with respect to the pin 41.
In view of the foregoing it can be seen that the position of the first trigger 34 selectively prevents or permits rotation of the second trigger 36. Again, movement of the first trigger 34 causes tandem movement of the second trigger 36, which results in the follower 102 first traversing along the leg 108 of the channel 104. However, movement of the second trigger 36 relative to the first trigger 34 is prevented due to interference between the cam follower 102 and the shoulder 106. Relative movement of the second trigger 36 with respect to the first trigger 34 is thus prevented until the cam follower 102 is moved to a position at which the cam follower 102 no longer abuts the shoulder 106. FIG. 9D shows the position of the follower 102 after movement of the second trigger 36 relative to the first trigger 34 is permitted and the second trigger 36 has also been actuated to its second position, thereby corresponding to the configuration of the applicator 10 shown in FIG. 4.
The channel 104 is shaped with another leg 112 that enables the follower 102 to continue to traverse the channel 104 such that the second trigger 36 can again move in tandem with the first trigger 34 as the first trigger 34 is moved to reopen the jaw assembly 16, i.e., as the first trigger 34 is moved back toward its first position. It is to be appreciated that the leg 112, similar to the leg 108, is formed along an arc that is concentric to the pivot 40. This accordingly enables the cam follower 102 to travel along the leg 112 as the second trigger 36 moved in tandem with the first trigger 34 as the first trigger 34 is rotated about the pivot 40. FIG. 9E accordingly shows the corresponding location of the follower 102 in the channel 104 when the first trigger 34 is returned to its first or initial position, which may correspond to the applicator 10 assuming the configuration of FIG. 5 in which the jaw assembly 16 is again opened.
It is to be appreciated that the channel 104 can take other shapes in other embodiments depending on the desired relative movement of the first and second triggers 34 and 36 relative to each other and to the handle 32. More specifically, the channel 104 will include a leg or portion for each optionally desired stage of movement of the first trigger 34 and of the second trigger 36, with the legs and/or portions of the channel 104 being concentric with respect to the pivot about which rotation is desired for each stage of movement. Thus, in order to sequentially permit (i) tandem movement of both of the first and second triggers 34 and 36 about a first pivot (e.g., the pivot 40), then (ii) movement of the second trigger 36 relative to the first trigger 34 about a second pivot (e.g., the pivot 41), and then (iii) tandem movement of the first and second triggers 34 and 36 again with respect to the first pivot, the channel 104 will include two legs (e.g., the legs 108 and 112) that are spaced apart but both concentric with respect to the first pivot (e.g., the pivot 40), which enables the movements of stages (i) and (iii), and a transverse portion (e.g., the portion 110) connecting between the two legs (e.g., the legs 108 and 112) that is formed concentrically with respect to the second pivot (e.g., the pivot 41) to enable the movement of stage (ii).
From the above description and the FIGS. 9A-9E, it is clear that the interlock 100 accordingly prevents rotation of the second trigger 36 until after the trigger first 34 is first rotated, preferably fully rotated (i.e., from a first position to a second position). Since full rotation of the first trigger 34 (e.g., as shown in FIG. 3) corresponds to the closing of the jaw assembly 16, the interlock 100 thus advantageously selectively prevents retraction of the studs 26 (due to rotation of the second trigger 36) until after the jaw assembly 16 is closed. Referring again to the above description, it is again noted that the interlock 60 is released depending on the position of the second trigger 36 relative to the first trigger 34. Thus, the location of the first trigger 34 is first used to release the interlock 100, selectively permitting movement of the second trigger 36 relative to the first trigger 34, and thereafter the location of the second trigger 36 relative to the first trigger 34 is used to release the interlock 60, which selectively permits movement of the first trigger 34 relative to the handle 32 back toward the initial position for the first trigger. In this way, the aforementioned order of the steps of (1) closing the jaws, (2) retracting the studs, and (3) opening the jaws is maintained and ensured by use of either or both of the interlocks 60 and 100.
It is to be appreciated that the interlock 100 can take other forms in non-illustrated embodiments. For example, in one embodiment the channel 104 is alternatively formed with the second trigger 36 and the follower 102 with the handle 32. In another embodiment, part of the channel 104 is formed in one of the handle halves while the other is formed in the other of the handle halves.
Referring now to FIG. 11, one specific example of use is illustrated. In this example, the fastener applicator 10 is used to deliver one of the fasteners 22 over the base of a left atrial appendage LAA in an open chest, beating heart procedure. The sternum S is opened, spreading the ribs R to provide a working space over the heart. After opening the pericardial sack, the heart may be lifted and turned, for example using a sheet of gauze or other material which is placed behind the heart, to expose the left atrial appendage within the opening as shown in FIG. 10. After the left atrial appendage LAA is exposed, the jaws 18 and 20 of the fastener applicator are placed around the base of the appendage by manipulating the shaft 12, as shown in FIG. 10. The angle of the jaws 18 and 20 relative to the shaft, typically about 15°, is highly advantageous as it allows the jaws to engage the base of the left atrial appendage so that they arc generally parallel with the os between the appendage and the left atrium LA. If the plane of the jaws was aligned with the shaft, it would be difficult to achieve this orientation and the risk of closing the appendage and leaving a cul-de-sac (an open space beyond the os and into interior of the left atrial appendage) is greatly increased. Such cul-de-sac is problematic as it can be a source of clotting and, if created, must be closed in the same or later procedure. Once the jaws 18 and 20 properly position the fastener 22 about the base of the left atrial appendage, the jaws are actuated and the fastener deployed as described previously.
While the invention has been described with reference to an exemplary embodiment or embodiments, it will be understood by those skilled in the art that various changes may be made and equivalents may be substituted for elements thereof without departing from the scope of the invention. In addition, many modifications may be made to adapt a particular situation or material to the teachings of the invention without departing from the essential scope thereof. Therefore, it is intended that the invention not be limited to the particular embodiment disclosed as the best mode contemplated for carrying out this invention, but that the invention will include all embodiments falling within the scope of the claims. Also, in the drawings and the description, there have been disclosed exemplary embodiments of the invention and, although specific terms may have been employed, they are unless otherwise stated used in a generic and descriptive sense only and not for purposes of limitation, the scope of the invention therefore not being so limited. Moreover, the use of the terms first, second, etc. do not denote any order or importance, but rather the terms first, second, etc. are used to distinguish one element from another. Furthermore, the use of the terms a, an, etc. do not denote a limitation of quantity, but rather denote the presence of at least one of the referenced item.
1-11. (canceled)
12. A fastener applicator comprising:
a handle;
a first trigger coupled rotatably with respect to the handle;
a second trigger coupled rotatably with respect to the handle; and
an interlock disposed with the second trigger, the interlock comprising a cam follower engaged in a cam channel that selectively prevents rotation of the second trigger relative to the first trigger depending on a location of the cam follower within the cam channel, wherein the location of the cam follower in the cam channel is set by a position of the first trigger.
13. The applicator of claim 12, wherein the handle includes the cam channel and the second trigger includes the cam follower.
14. The applicator of claim 12, wherein the cam channel has a first leg that permits tandem movement of the second trigger with the first trigger during closing of the first trigger and a shoulder that prevents movement of the second trigger relative to the first trigger until the first trigger is closed.
15. The applicator of claim 14, wherein the cam channel has a second leg that permits tandem movement of the second trigger with the first trigger during re-opening of the first trigger after the second trigger has been closed relative to the first trigger.
a shaft extending distally from the handle;
a jaw assembly at a distal end of the shaft having one or more fastener supporting structures;
a first trigger coupled movably with respect to the handle, the first trigger coupled to the jaw assembly such that movement of the first trigger relative to the handle selectively closes the jaw assembly;
a second trigger coupled movably with respect to the first trigger, the second trigger coupled to the jaw assembly such that movement of the second trigger relative to the first trigger selectively retracts the one or more fastener supporting structures; and
an interlock coupled to the second trigger and operatively arranged to selectively prevent movement of the second trigger relative to the first trigger depending on a position of the first trigger.
17. The applicator of claim 16, wherein the interlock permits movement of the second trigger relative to the first trigger when the first trigger is closed and prevents movement of the second trigger relative to the first trigger when the first trigger is open.
18. The applicator of claim 16 further comprising a second interlock coupled to the first trigger and operatively arranged to selectively prevent movement of the first trigger relative to the handle depending on a position of second trigger.
19. The applicator of claim 16, wherein the interlock includes a cam follower engaged with a cam channel.
21. The applicator of claim 16, wherein the second trigger is movable in tandem with the first trigger during movement of the first trigger.
a first trigger movable with respect to the handle between a first position and a second position;
a second trigger movable with respect to the first trigger between an initial position and an actuated position;
a first interlock coupled to the second trigger and operatively arranged to selectively prevent movement of the second trigger relative to the first trigger until the first trigger is moved into the second position; and
a second interlock coupled to the first trigger and operatively arranged to selectively prevent movement of the first trigger relative to the handle until the second trigger is moved into the actuated position.
23. The fastener applicator of claim 22 further comprising a pair of jaws, the first trigger coupled to the pair of jaws for setting the pair of jaws in an open configuration when the first trigger is in the first position and in a closed configuration when the first trigger is in the second position.
24. The fastener applicator of claim 23 further comprising one or more fastener supporting structures disposed with the pair of jaws, the second trigger coupled to the one or more fastener supporting structures for setting the one or more fastener supporting structures in a deployed configuration when the second trigger is in the initial position and in a retracted configuration when the second trigger is in the actuated position.
25-32. (canceled)
Applicant: DATASCOPE CORP. (Mahwah, NJ)
Inventors: William K. WHEELER (Berthoud, CO), Ashik A. MOHAN (Petaluma, CA)
International Classification: A61B 17/10 (20060101); A61B 17/128 (20060101); A61B 17/122 (20060101); A61B 17/08 (20060101); A61B 17/072 (20060101); A61B 17/064 (20060101);


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In view of the congestion apparent at many international airports, the ownership of slots at certain airports (the right to take-off or land an aircraft at a particular time of day or night) has become a significant tradable asset for many airlines. Clearly take-off slots at popular times of the day can be critical in attracting the more profitable business traveler to a given airline's flight and in establishing a competitive advantage against a competing airline.
The pattern of ownership has been privatized in the recent years, that is, the ownership has gradually changed from governments to private and individual sectors or organizations. This occurs as regulators permit greater freedom and non-government ownership, in steps that are usually decades apart. This pattern is not seen for all airlines in all regions.[87]
Where to stay in Crete: Adults-only Casa Cook is a chic little number that breaks all the rules about package holidays (you'd never know it was created by Thomas Cook). The Marco Polo is a 15th-century mansion decorated like a pasha's harem, with an enchanting garden restaurant. Ottoman-style suites at Melenos Lindos have hand-painted ceilings and carved platform beds.
The other groups are best tackled individually. For example, the Ionians have no ferry connections to the rest of the Greek islands; the same story with the Sporades and the Argo-Saronics. The NE Aegean islands do have a link to the Dodecanese and the Cyclades but are probably best left for another trip once you have got the feel of the rhythm of the Greek islands.
Bilateral agreements are based on the "freedoms of the air", a group of generalized traffic rights ranging from the freedom to overfly a country to the freedom to provide domestic flights within a country (a very rarely granted right known as cabotage). Most agreements permit airlines to fly from their home country to designated airports in the other country: some also extend the freedom to provide continuing service to a third country, or to another destination in the other country while carrying passengers from overseas.
Considering your interests (great food, hiking, beaches, nightlife unimportant) then Naxos should definitely be your other island. (And Naxos has many daily ferry connections with both Santorini and Athens.) Also, Athens needs at least one full day to explore so you should drop any thoughts about Delphi or Nafplio. Also, I would look into flights from Athens to Santorini on your night of arrival. If you could get to Santorini that night (and move your day in Athens to the end of your trip) you'd almost gain an entire day and could spend two nights on Naxos.
Another South Pacific island group (see a pattern here?), the Cook Islands are pretty far off the map. OK, not too far, but they are considerably less visited than some of their neighbors. These tiny islands are named after James Cook, the intrepid man who discovered them. With few amenities, this is the best place to find your inner castaway and escape modern life. The islands see similar weather to the rest of the area, with temperatures hot and humid all year round.
On 25 August 1919, the company used DH.16s to pioneer a regular service from Hounslow Heath Aerodrome to Le Bourget, the first regular international service in the world. The airline soon gained a reputation for reliability, despite problems with bad weather, and began to attract European competition. In November 1919, it won the first British civil airmail contract. Six Royal Air Force Airco DH.9A aircraft were lent to the company, to operate the airmail service between Hawkinge and Cologne. In 1920, they were returned to the Royal Air Force.[7]
We are wanting to hit 3 islands and have narrowed it down to Corfu, Crete, and Santorini. I was feeling pretty good about this but I haven't seen a lot of hype for Corfu. I was thinking it would be more unique as compared to the other 2 with its proximity to Italy and Turkey and Albania. Am I missing something, do you have any insight you could provide, please?
Which of these great locations would you recommend for a family with teenagers who like to dive and surf? We have been to Hawaii, Costa Rica and Tahiti. We are looking for a safe, yet different, cultural experience with exotic plants, fish and animals. We would prefer to stay in one villa, as opposed to multiple rooms in a hotel. We don't mind if it is far away from Southern California. I realize this may be painful financially.
There are many picturesque villages to explore, and the beaches are always far from crowded. If you like walking, the lush vegetation and cliffs are ideal, while if you like to do some underwater exploration, there are many scuba diving and fishing opportunities, too. Additionally, Dugi Otok is home to one of Croatia's best sandy beaches, Sakarun, which some compare to the beaches of the Caribbean, making it a great family spot.
The United States, Australia, and to a lesser extent Brazil, Mexico, India, the United Kingdom, and Japan have "deregulated" their airlines. In the past, these governments dictated airfares, route networks, and other operational requirements for each airline. Since deregulation, airlines have been largely free to negotiate their own operating arrangements with different airports, enter and exit routes easily, and to levy airfares and supply flights according to market demand. The entry barriers for new airlines are lower in a deregulated market, and so the U.S. has seen hundreds of airlines start up (sometimes for only a brief operating period). This has produced far greater competition than before deregulation in most markets. The added competition, together with pricing freedom, means that new entrants often take market share with highly reduced rates that, to a limited degree, full service airlines must match. This is a major constraint on profitability for established carriers, which tend to have a higher cost base.
Nine weeks in Greece is a dream itinerary it certainly gives you lots of flexibility. As you seem to have Athens and the Peloponnese sorted, you just need to sort out your five weeks on the islands. What you need to realize, however, is that the islands are not all mutually interconnected, but rather they are 'grouped' – both administratively and from the point of view of transport routes. Here are the main groups.
Following World War I, the United States found itself swamped with aviators. Many decided to take their war-surplus aircraft on barnstorming campaigns, performing aerobatic maneuvers to woo crowds. In 1918, the United States Postal Service won the financial backing of Congress to begin experimenting with air mail service, initially using Curtiss Jenny[26] aircraft that had been procured by the United States Army Air Service. Private operators were the first to fly the mail but due to numerous accidents the US Army was tasked with mail delivery. During the Army's involvement they proved to be too unreliable and lost their air mail duties.[27] By the mid-1920s, the Postal Service had developed its own air mail network, based on a transcontinental backbone between New York City and San Francisco.[28] To supplement this service, they offered twelve contracts for spur routes to independent bidders. Some of the carriers that won these routes would, through time and mergers, evolve into Pan Am, Delta Air Lines, Braniff Airways, American Airlines, United Airlines (originally a division of Boeing), Trans World Airlines, Northwest Airlines, and Eastern Air Lines.
In postcard-pretty Artemonas, all roads lead to Theodorou, purveyors of nougat wafers and almond sweets since 1933. You can eat in your bikini at Omega 3, where locally foraged and fished ingredients are given an exotic twist: baby-calamari tempura, smoked eel in chilled melon soup with wasabi, and chickpea sorbet with wild apricot jam and pine nuts. Lobsters are plucked straight from the sea at Heronissos, then served with spaghetti on the jetty. It's just the right balance of low-key luxury and unspoiled authenticity. Rather like Sifnos itself.

redpajama_set_name: RedPajamaCommonCrawl


Use this online American History quiz entitled Reconstruction after The Civil War Quiz to test your knowledge on the era of reconstruction after the American Civil War.
This quiz will also test your knowledge about the efforts of freed slaves and their Republican allies to gain equality in postwar America, and the stubborn attempts of the South to suppress the rights of blacks through elaborate legal codes and intimidation. This online quiz contains 25 questions from a pool of over 100 thereby allowing repeat use. We recommend that students study the relevant videos provided on this site on this subject before attempting this quiz.


The 2018 National Football League (NFL) season kicks off Thursday, September 6th at 8:20 pm. The Atlanta Falcons will be traveling to Pennsylvania to face off against the Philadelphia Eagles at the Lincoln Financial field. The Falcons ended their season last year with a record of 10-6 and they lost to the Eagles in the second round of the playoffs. The Eagles, on the other hand, ended their last season with a record of 13-3 and they defeated the New England Patriots in Super Bowl 52 for the championship. Tune in on NBC Thursday at 8:20 pm to see the Eagles and Falcons go head to head in game one of the 2018-2019 NFL season.


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Kiki Goshay
Goshay Productions
Founder & Filmmaker
Kiki Goshay is the founder of Goshay Productions, where she has worked on both narrative and documentary films. Her passion is to use the media for positive social impact.
Empowered, documentary film celebrating the research, technology, innovation and collaboration that has paved the way for a renewable energy future. Producer/Director 2019
Not Alone, documentary film created to shed light and end the stigma around teen mental illness and prevent youth suicide. Producer/Director 2017
The Job, feature film. Producer, 2008
Shades of Green, television pilot. Producer, 2008
How to Eat Your Watermelon in White Company… and Enjoy It, feature documentary film on the life of black filmmaker, Melvin Van Peebles. Executive Producer, 2004
Kiki is an active advocate for the environment and children. She became a licensed foster care parent in 2012. Raising children who come into foster care, she has become a passionate supporter of organizations that assist underprivileged children with their mental health and education. She is a board member of Greenlight Clinic, a free mental health clinic for 14-26 year olds.
Kiki was a founding Board Member of Cool The Earth, a free, ready-to-run climate change assembly program that educated K-8 students and their families about climate change and inspired them to take simple actions to reduce carbon emissions.
Kiki has demonstrated her strong commitment to a better environment by designing and building a sustainable LEED Gold house (built in 2013).
From 1988 to 2000, Kiki created, manufactured, and marketed a line of organic snack foods through her company Mill Valley Organic & Natural Foods.


Are you looking for commercial sectional garage doors? Potomac Garage Solutions offers a large variety of sectional garage doors and installation options to companies. Our wide selection of sectional garage doors will meet your needs for security, functionality and durability.
Potomac Garage Solutions's doors offer an array of different purposes depending on the design of your facility and its intended use. Our doors are custom installed for and can be motorized upon request for easier use. Models on offer include a large array of options for insulation, panel design and color. Sectional doors come with a variety of options for windows, including insulated glass for better fire and weatherproofing.
If you are uncertain of what type of sectional garage door to install, Potomac Garage Solutions offers free consultations to help you understand your options. The size and shape of your work space, the nature of your business and the types of risks you face will all be evaluated and we will help you find a sectional garage door solution that will be both effective and affordable.
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To request a free quote for sectional garage doors, contact us at 240-650-2622.
Potomac Garage Solutions – Your trusted source for commercial sectional garage doors.


Wizard Framework enables easy switching between two specifications for look and feel: Wizard 97 and Aero Wizard. You can specify that your application switches automatically depending on the version of Windows on which you are running, but the themes look good no matter what environment they are in. You can see some of the appearances below.
Some of the images below have been reduced in quality for thumbnail purposes; click on the images to open the full high-quality versions.
Demonstration Application running on Windows Vista using the Aero Wizard specification. Note Aero Glass in the client area.
Demonstration Application using the Wizard 97 specification.
Demonstration Application using the Aero Wizard specification but running under Windows XP.


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Q: Prove that set of regularisable sample paths is measurable I am currently working through Rogers and Williams Diffusions, Markov Processes and Martingales Volume 1 (or rather lecture notes based on it) and am unable to understand the proof of corollary II.62.12:

If $\{Y_q: q\in\mathbb{Q}^+\}$ is an $\mathbb{R}$-valued stochastic process carried by $(\Omega, \mathcal{G}, \mathbb{P})$ then $G:=\{\omega: q\rightarrow Y_q(\omega)\text{ is regularisable }\}\in\mathcal{G}$

Proof: The previous theorem allows us to exhibit $G$ as a $\sigma$-cylinder, which is then automatically in $\mathcal{G}$. Do think this through.

where the preceding theorem states that

Let $y:\mathbb{Q}^+\rightarrow \mathbb{R}$. Then $y$ is regularisable if and only if whenever $N\in\mathbb{N}$ and $a,b\in\mathbb{Q}$ with $a<b$ we have both $\sup\{|y_q|: q\in\mathbb{Q}^+\cap[0,N]\}<\infty$ and $U_N(y;[a,b])<\infty$

where $U_N(y;[a,b])$ is the number of upcrossings of $y$ in $[a,b]$. Additionally, $\sigma$-cylinders for $\mathbb{R}$-valued processes with $\mathbb{Q}^+$-time are defined as those elements of $\mathcal{B}(\mathbb{R})^{\mathbb{Q}^+}$ that can be written as $\pi_S^{-1}A_S$ where $S$ is a countable subset of $\mathbb{Q}^+$ and $A_S\subseteq \mathcal{B}(\mathbb{R})^S$ (which I'm pretty sure is just any element of $\mathcal{B}(\mathbb{R})^{\mathbb{Q}^+}$)
Whilst I do understand the theorem, I do not understand what the proof of the corollary has to do with it. I also don't see how $G$ can be a $\sigma$-cylinder since it is supposed to be an element of $\mathcal{G}$ and not of $\mathcal{B}(\mathbb{R})^{\mathbb{Q}^+}$. Our professor did say that we have to take countable intersections and then see that these are still in the $\sigma$-algebra, but I do not see which elements of which $\sigma$-algebra we're supposed to be intersecting.
Edit: after thinking about the corollary for a bit I'm fairly certain that the intersections my professor was hinting at were $$\bigcap_{N\in\mathbb{N}, a<b\in\mathbb{Q}}\{\omega: q\rightarrow Y_q(\omega) \text{ satisfies } U_N(y;[a,b])<\infty\}$$ intersected with $$\bigcap_{N\in\mathbb{N}, a<b\in\mathbb{Q}}\{\omega: q\rightarrow Y_q(\omega) \text{ satisfies } \sup\{|y_q|: q\in\mathbb{Q}^+\cap[0,N]\}<\infty\}$$ though that still leaves me unsure how to prove that $\{\omega: q\rightarrow Y_q(\omega) \text{ satisfies } U_N(y;[a,b])<\infty\}\in\mathcal{G}$ for $N\in\mathbb{N}, a<b\in\mathbb{Q}$ (and the same for the other property).

redpajama_set_name: RedPajamaStackExchange


Looking for Travel Agents in Livingstone, Zambia? Find the list of best Travel Agents in Livingstone, Zambia on our business directory.
Hot tires tours and travel is a registered company based in Livingstone,deal with hotel,airpot transfers and activities.


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For Those Who Missed It...
For those who missed Ken Welch's inspiring speech on election night for those who would like to experience it again, here is a transcript.
The Pinellas Democratic Party is incredibly proud of the part we played in electing the most qualified candidate as well as the first African American Mayor in St Petersburg.
Ken Welch's Speech, Election Night, November 2, 2021
You all look wonderful tonight!
This is what our St. Pete looks like...
This is what unity looks like….
This is what progress looks like….
In this campaign, for three years, in Zoom meetings, neighborhood forums, youth summits, in houses of worship and places of business, and yes even while driving Uber and Lyft for 1,000 rides (with a 4.97 rating), we've asked a simple question. What does progress look like?
And the answer from the community is clear — across the spectrum of age, race, gender, orientation, faith, or neighborhood — the response from the people of St. Petersburg was consistent with our vision of Inclusive Progress for all and our guiding principles.
Tonight's election victory confirms the desire of the people of St. Petersburg for leadership that will move us forward, not backward. That's the definition of progress. Assuring that today is better than yesterday and tomorrow is better than today. And that's what the people have clearly stated that they want, in this election!
When we asked the people, "What does progress look like?" — from students last week at Campbell Park Elementary to seniors at Westminster Senior Living and every venue in between — the answers were consistent.
• The people said that progress means affordability for the people who call St. Petersburg home. It means affordable rent and home ownership, affordable water bills, transportation options and taxes.
• The people said that progress means safe and healthy neighborhoods — where every child sees opportunity and hope, and health, education and nutrition disparities are addressed as priorities.
• The people say that progress means smart growth that protects our environment, invests in our infrastructure and preserves St. Pete's character.
• And the people agree with my firmly held belief that facts matter. As our founding father
John Adams said, "Facts are stubborn things."
We will approach every issue Informed by facts, data, science and. importantly, our history. History is important because we must fully understand where we are coming from as a community, to determine where we want to go, and to perfect our path forward.
And importantly all of our work should be built upon a strong foundation of equity, inclusion, diversity and community benefit.
That is how we will build inclusive progress for St. Petersburg.
I want to thank the residents of St. Petersburg for your belief that we live in a great city — but we can be better. To reach our highest potential, we must be better. We must work every day to make sure that our city is great for everyone. From our youth to our seniors, the entrepreneur in the Grand Central District, the Brayboy's next door at Chief Creoles on the Deuces, the emerging artists in the Warehouse Arts District, and our businesses in downtown and the Gateway area, and every neighborhood, business and community in our great city — yes, that includes the West Side Commissioner Justice. (Note: The mayor-elect later explained that this was a mild ribbing of his good friend, Pinellas Commissioner Charlie Justice: "Charlie and I have a good-natured west side/south side rivalry. He's a Boca Ciega High School Pirate. I'm a Lakewood Spartan. It's all in fun.")
I'd like to thank all of the candidates who ran for mayor and City Council. I also want to thank Robert Blackmon for his phone call a few minutes ago conceding the race. I wish him well. It's time to move forward.
We are truly in this together, and our collective potential is only limited by our ability to connect every part of our community with access to opportunity and equitable investment. We will listen, and our administration will be In-Touch with the people whom we serve.
We have to enter this work with a clear-eyed view. The work before us will be challenging — we face the same economic, social, and environmental challenges as any other American city. Some issues, like our changing climate and sea level rise, are particularly pressing issues in our city, and affect everything from housing affordability and growth management to transportation.
But these challenges are not insurmountable — we can and will make real progress through prioritizing, resourcing, partnership and the hard work of long-term strategic decision making. We can't kick the can down the road on the pressing issues — be it climate change, public safety, infrastructure, poverty, or equity. Progress will require honest and sometimes difficult conversations, innovation, and determination. That is the path to progress in these challenging times, and I look forward to our collective work to achieve these goals.
Finally, I want to acknowledge just a few folks.
Any elected official or candidate will tell you that when you run for office, your whole family runs. My family has always supported me, even when our faith was tested. So, I want to thank my wife Donna, daughters Keonna and Kenya, sister Katrina, nephew Tre, nieces Keina and Andressa. And to the hundreds of folks in the Welch, Davis, Brown Mckenzie, Boykins family — thank you for always being there.
Special thanks to our queen, our matriarch, my mother Alletha — she is the beauty and the political brains of the family. To this day, her political instincts and advice is providential. I love you, Ma.
My father was my role model for me — he showed me every day what fatherhood, humility, and public service all about is. 30 years ago, my father ran for mayor. This is his button. When he ran in 1991, he faced death threats — it makes the petty attacks on me during this campaign pale in comparison. Dad's example, and the example of thousands of other pioneers, taught me what real strength and courage looks like, and the value of perseverance.
As I close, I want to thank you all for your support.
I want to thank a tremendous young leader — Kymbriell Finch — for introducing me. Kymbriell is the granddaughter of former St. Petersburg Police Officer Freddie Crawford of the Courageous 12. Kym, you are taking up his mantle of community leadership. Thank you.
I would not be standing here today as mayor-elect of St. Petersburg but for the grace of God, and in my personal faith I believe that certain people are placed in our lives as mentors and role models. I have personally learned from outstanding mentors since I was a boy — leaders like Vyrle Davis, Perkins Shelton, Lonnie Donaldson, Adele Vaughn Jamison, Ernst Fillyau and Winnie Foster to name a few.
There are many giants still with us. Pioneers like Leon Jackson of the Courageous 12 — who led an historic fight for equality for Black police officers in the city. Gwen Reese, keeper of our history and culture, and Watson Haynes, an iconic leader who continues to lead and inspire. And my mentor and former colleague Commissioner Bob Stewart. There are many others that time doesn't permit me time to name but thank you all for your example of leadership.
I want to thank our current mayor, Rick Kriseman, for leading our city to new heights. He's a great leader, and despite the fact that he's a Florida Gator, he's a great friend. He's participating in a Global Climate Summit in Scotland today, and we wish him Godspeed.
To my endorsers — elected, community, faith and business leaders, supporters, volunteers, prayer warriors, friends and voters, thank you for your support, and your hard work. I will need your continued support and collaboration as we get to work — this is the start, not the end of our journey.
Finally, to my team, #TeamWelch, you are the best. You mapped out a plan to reach the voters, and we stayed focused on our positive message of inclusive progress. We knocked doors, called, texted, did our homework and reached the voters through mail, TV, social media and radio.
I'm proud that my team, endorsers, and supporters, reflect our entire community. Black, white, straight, LGBTQ+, Latinx, from different parties, neighborhoods, faith experiences and ages. I'm proud of our partnership, and our unifying goal of progress, equity, and equality for all.
This election has made history in St. Petersburg, and it is my distinct honor to be the first African-American mayor of my hometown. But let me be clear in stating that "making history" in and of itself, has never been the priority of this campaign nor will it be the focus of my administration. One of my guiding principles of governance (available at Kenwelch.com) is community impact, inclusive progress that improves the lives or our residents, the resiliency of our community and links every person with the opportunity to become their best and authentic self — that is inclusive progress and that will be the focus of my administration.
For me "making history" without making a positive impact is an empty achievement. So, our election victory must be followed by a purposeful agenda of opportunity, accountability, and intentional equity for our entire community, and working in partnership with you, and every person and organization who will join our partnership for progress — we will build impactful, inclusive progress for St. Petersburg. Let's get to work. Thank you.


This topic contains 1 reply, has 2 voices, and was last updated by Bruce Peck 3 years, 11 months ago.
There is a gentlemen who repairs transponders that I saw last year at MIS and Mid-Ohio. Does anyone have the contact information for this person? Thanks in advance.
It's not the individual you're talking about, but this guy will replace batteries. He is an RC car enthusiast and mainly does transponders for those, but he will do the Tranx-160's that we use in karting. He did one of the older squared off transponders for me a couple of years ago and it's working great. He runs a HVAC business and doesn't do a lot of these during his peak busy seasons, but contact him from this page and he will tell you if/when he can do yours.


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In the last few months I have worked really hard to put together a introductory course in data coding for those who are new to Data Science. I've selected bash (aka the command line) as the first data language to show you, because I find it easy to interpret – even for first timers.
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text:
Q: OK Button crashes in wxPython I'm working on XP and using WX python As GUI library. Recently I look a lot of problems, for example If I Use a  @MikeDriscoll 's example the code at the second print the python interpreter crashes, and I don't know why and how track this error (more important)...
import wx

########################################################################
class SampleDialog(wx.Dialog):
    """"""

    #----------------------------------------------------------------------
    def __init__(self, parent):
        """Constructor"""
        wx.Dialog.__init__(self, parent, title="Tutorial")
        print "Hello Here"
        btnOk = wx.Button(self, wx.ID_OK)
        print "Hello Here"
        btnCancel = wx.Button(self, wx.ID_CANCEL)
        btnSizer = wx.StdDialogButtonSizer()
        btnSizer.AddButton(btnOk)
        btnSizer.AddButton(btnCancel)
        btnSizer.Realize()
        self.SetSizer(btnSizer)

#----------------------------------------------------------------------
if __name__ == '__main__':
    app = wx.App(False)
    dlg = SampleDialog(None)
    dlg.ShowModal()


text:
John Everett & Sons Funeral Home at Natick Common
Send Flowers for Marie
Marie Welton Thomas
August 8, 1932 ~ January 4, 2021 (age 88)
Marie Welton Thomas, of Medfield MA, went to be with the Lord on January 4, 2021, at the age of 88. Born in Poughkeepsie NY, she was the daughter of the late Robert E. and Johanna (Haverkamp) Welton. Devoted mother of Mark Thomas and his wife Rebecca of Niskayuna NY, Karen Johnson and her husband Kevin of Natick MA, the late John Rogers Thomas, Jr., and his surviving wife Patricia Thomas of Holliston MA. Loving grandmother of Johanna, Harry, Sam, Gregory, Jessica, and Irene Thomas, Jocelyn Moruzzi, and Samuel, Cole, Grace, and Luke Johnson. Sister of the late Barbara Jean Varuzzo.
Marie grew up in the wake of the Great Depression. At the age of 12, Marie cared for her infant sister while her parents worked. She became an accomplished baton twirler and went on to win the New York State baton twirling championship at age 16. Gifted with a beautiful voice, Marie sang as a soloist with the IBM Dance Band and the IBM Mixed Chorus. Marie appreciated beautiful things and had a keen eye for fashion and design. Two of her hobbies included creating stained glass fixtures and restoring antiques. She enjoyed working in the garden, and cultivated an 85-foot flower garden bed. Marie was a Real Estate Agent for many years for C.J. Patrick and Lavery Real Estate in Poughkeepsie NY, and later for Medfield Properties in Medfield MA. She was a member of the choir at her church home, Trinitarian Congregational Church in Wayland MA. Marie's wonderful sense of humor, love of laughter and live-for-the-moment personality did not prevent her from being a shrewd negotiator, and one who rarely lost a contest when "the right thing to do" was at stake. Above all, Marie delighted in spending time with her family, always extending herself to show love and support.
Relatives and friends are kindly invited to attend the visiting hours on Thursday January 7, 2021 from 4-8 PM in the John Everett & Sons Funeral Home, 4 Park St., NATICK COMMON. Funeral service will be private. Interment will take place on Saturday January 9, 2021 at 11 AM at Rural Cemetery in Poughkeepsie NY. Donations in Marie's memory may be made to St. Jude Children's Research Hospital (www.stjude.org/donate).
For directions and guestbook, please visit www.everettfuneral.com.
To send flowers to the family or plant a tree in memory of Marie Welton Thomas, please visit our floral store.
4 Park Street
Poughkeepsie NY, Rural Cemetery
© 2021 John Everett & Sons Funeral Home at Natick Common. All Rights Reserved. Funeral Home website by CFS & TA | Terms of Use | Privacy Policy


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Senate Democratic Caucus Organized
On March 6, 1903, the faction-ridden Senate Democratic caucus decided it was time to get organized. On that day, for the first time in the Senate's history, the caucus formally elected a chairman and a secretary, agreed to keep regular minutes of its proceedings, and took steps toward the adoption of a "binding rule."
When Republican president Theodore Roosevelt called the Senate into special session on March 5, 1903, to consider ratification of a Panama Canal treaty, the Democratic caucus unanimously selected Maryland's Arthur Gorman as chairman. The dominant figure in late 19th-century Maryland political life, Gorman was a masterful legislative strategist and party loyalist. Based on his informal service as Democratic leader in the 1890s, his Senate colleagues believed he was just the man to revitalize their heavily outnumbered party in the early 1900s.
Gorman convened the caucus on March 6, 1903. The newly elected secretary, Tennessee senator Edward Carmack, presumably began to keep regular minutes. Although the formal record of that session has not survived, the following day's Washington Post provided a richly detailed account. The existing minutes begin with the meeting of March 16, 1903. Democratic senators who opposed the pending Panama Canal treaty sought to unite their party by proposing a rule that would bind all 33 members to any decision approved by two-thirds of the caucus. The action, agreed to later that year, marked the first time a party caucus sought to exercise such a binding rule.
Adoption of the binding rule promoted a distinction between the terms "caucus" and "conference." As these words came to be used, senators were in "caucus" when they discussed whether or not to bind the party's vote on a given issue; they were in "conference" when considering election of officers or general legislative business.
Minutes of the U.S. Senate Democratic Conference, 1903-1964


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