Could Ford's Rise with Youth Send Toyota the Way of Oldsmobile?
My grandpa drove an Oldsmobile.
Maybe if it had been a cool one, like an old Starfire or something, my perception of the brand would have been different. But his car was anything but cool… an early '90s Cutlass Ciera. Eww.
So it was no real surprise to me when Oldsmobile closed shop. In my mind, it simply ran out of customers. What young person would want to buy a car with "Old" right in the name?
Today I have to wonder if Toyota could follow that same path.
To me, Toyota symbolizes quality and reliability. To younger people, the brand perception is being built around conservative styling, mass recalls, and congressional hearings. Not exactly ways to build trust with Generation Y.
Young people now entering the car-buying world are much less familiar with Toyota's stellar history. Their parents might recommend a Toyota, but that would be like my grandpa telling me to go buy an Olds.
So where are the young people looking today? Ford.
According to a Detroit News story, young car buyers are being drawn into Ford dealerships by the automaker's technology, and they are bringing their parents with them. That's pretty good proof that Ford's gamble to sell technology by partnering with Microsoft and Sony is paying off.
With Ford's Sync technology, drivers can control their cell phones and music players with voice commands. That's the kind of thing that will influence how iPad-obsessed members of Gen Y think about a car company. That, and the fact that Ford was the only U.S. automaker to rebuild its business without government help, bode well for a profitable future.
And no, I don't think Toyota will go out of business, but I do think it has some serious ground to make up with young people if it wants to keep pace with the Blue Oval.
Are there any compelling reasons for American youth to buy a Toyota instead of a Ford? I think in the youth market Ford is the hands-down winner?
Sync is terrible? I thought so at first too. But using voice to link up cell phones and music players in the car is brilliant. The next generation of car buyers want their life integrated to everything. Ford's on top of that and will grow along with Gen Y.
Tim makes good points. I will bet Toyota is well aware of their problems by now, and I would never count out what is still a very strong and successful company. They are using cars like the Scion to find a youth market–how well isn't yet clear. I think electronic gadgetry in cars, like the Ford-MS Sync, is terrible but it seems to win over the younger buyers.
I agree that unless Toyota makes some changes, they could follow GM's Oldsmobile brand, which was heavily discounted as the brand faltered and eventually met with oblivion. Is not Toyota currently heavily discounting their own brand? Although reeling from the current bad publicity, Toyota still leads the pack in terms of global market share.
One of Toyota's problems that is described in this post: they have been deaf to the "voice of the customer." This was not always the case. At one time, Toyota carefully analyzed their customers' needs, bringing to market the innovative Lexus luxury brand. As a result, they grabbed market share away from competitors such as BMW, Mercedes and Cadillac.
3) Revamp its organizational structure.
By fixing the root causes of their problems, Toyota may be able to compete with Ford for the allegiance of younger buyers.
Ford's got a lot of things going for it right now: the Sync system, the Focus Hybrid, improving reliability ratings, the fact that it didn't take bailout bucks, and Americans' desire to help our economy by buying from U.S. companies. And Toyota completely mishandled, at least initially, the PR nightmare of its recent unintended acceleration issues and recalls. I'd say Ford deserves to take some of Toyota's market share, particularly among young people.


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Immersing Wellbeing into the Culture of Work with Dr. Richard Safeer
Where Should Organizations Invest Their Resources to Best Support Well-being? Natalie Johnson and Rebecca Johnson share insights.
Helping Employees Make Better Healthcare Decisions with Tom Vertich
Houston We Have Takeoff: Building Employee Resilience through Benefits with Donna Fernandez
Reimagining Financial Wellness with Robert Kelley
The Evolution of Well-Being with Laura Kirk
The Crucial Role of the Clinical Pharmacist in Improving Healthcare Outcomes with Jessica Lea
Save Billions, Increase Participation Five-Fold, and Put $300 Million Into Employee Pockets – A Cleveland Clinic Case Study with Dr. Michael Roizen
Why Your Healthcare Vendors Need to Guarantee You At Least 2X Returns (Using 5th-Grade Math) with Lee Lewis
The Importance of Telling Your Organization's Well-being Story and How to Tell It, with Mitch Martens
Creating Inclusive Wellness and Well-being Programs That Work for Everyone with Laura Putnam
Why You Are Paying 20,000% More for Less Effective Prescription Drugs with Dr. John Abramson
The Untapped Potential of Paid Time Off with Veetahl Eilat-Raichel
How Happy Employees Create Happy Customers with Bruce Daisley
How Business Can Thrive in 2022 despite COVID-19 with Heather Saunders
What Does the Future of Virtual Care Hold for Businesses with Kate Brown
Predator or Prey – The PBM Games with Terri Dill
How to Cultivate a Winning Company Culture with Shane Green
Why Listening is Key to Organizational Success with Julian Treasure
How Your Company Can Take Advantage of the ERTC with Greg Nussbickel
About Jonathan Edelheit
Dr John Abramson
Dr. JOHN ABRAMSON has been on the faculty of Harvard Medical School for twenty years and is a lecturer in the department of health care policy. A former family doctor, he is the author of the acclaimed book Overdosed America: The Broken Promise of American Medicine and has made more than seventy-five appearances on national television shows, including the Today (twice), CBS Evening News, NBC Nightly News, CNN Morning America, CNN Headline News, Megyn Kelly Fox News, and the Dr. Oz Show. He has also appeared several times on NPR, including All Things Considered and On Point. He has written op-ed pieces in the New York Times, the Los Angeles Times, and other major outlets, and his writing has also appeared in The Lancet, the Journal of the American Medical Association, and other prestigious medical publications. He lives in the Boston area.
Copyright © 2022 Global Healthcare Resources. All Rights Reserved.

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Q: how to create a .aspx page dynamically in asp.net I have one page called First.aspx in website, int his page, I have a simple asp.net button.
What I want is, on the click event of that button, render a new dynamic "page" that can be opened in a new windows or tab.
How can I achieve this?
The new page is not in the website, this page create needs to be created at runtime and needs to be dynamic.

A: I Would suggest NOT to. As You are using server side language. you don't need to physically create a page. you can dynamically display page contents based on the URL Type in by Implementing Routing on your website.

A: protected void Button1_Click(object sender, EventArgs e)
    {

        File.Copy(Server.MapPath("") + "\\abc.aspx", (Server.MapPath("") + "\\" + TextBox1.Text + ".aspx"));
        File.Copy(Server.MapPath("") + "\\abc.aspx.cs", (Server.MapPath("") + "\\" + TextBox1.Text + ".aspx.cs"));

        //.aspx Page

        StreamReader sr = new StreamReader(Server.MapPath("") + "\\" + TextBox1.Text + ".aspx");
        string fileContent = sr.ReadToEnd();
        sr.Close();
        using (StreamWriter Sw = new StreamWriter(Server.MapPath("") + "\\" + TextBox1.Text + ".aspx"))
        {
            fileContent = fileContent.Replace("abc",  TextBox1.Text);
            Sw.WriteLine(fileContent);
            Sw.Flush();
            Sw.Close();
        }

        //.aspx.cs Page

        StreamReader sr1 = new StreamReader(Server.MapPath("") + "\\" + TextBox1.Text + ".aspx.cs");
        string fileContent1 = sr1.ReadToEnd();
        sr1.Close();
        using (StreamWriter Sw1 = new StreamWriter(Server.MapPath("") + "\\" + TextBox1.Text + ".aspx.cs"))
        {
            fileContent1 = fileContent1.Replace("abc", TextBox1.Text);
            Sw1.WriteLine(fileContent1);
            Sw1.Flush();
            Sw1.Close();
        }

    }

A: Not sure why you would want a physical page created when you could achieve similar results by storing information in a DB and have a generic page 'template' that reads from the db and populates the page depending on some other info such as the URL...
Anyway, here is a solution to your question, albeit somewhat old... creating aspx page dynamically in aspnet

redpajama_set_name: RedPajamaStackExchange


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USS Augusta ha sido el usado por cinco buques de la Armada de los Estados Unidos, los cuatro primeros por la ciudad de Augusta (Georgia),  y el quinto por Augusta (Maine).
 fue un bergantín en servicio desde 1799 hasta 1801.
 fue un barco de vapor, adquirido por la Armada en 1861 y vendido en 1868.
, en servicio desde 1917 a 1918.
 fue un crucero pasado de la clase Northampton, en servicio desde 1931 hasta 1946.
 fue un submarino clase Los Angeles, puesto en servicio en 1985 y dado de baja en 2008.

Nombres de buques de guerra de Estados Unidos

redpajama_set_name: RedPajamaWikipedia


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1990 SP9 (asteroide 35084) é um asteroide da cintura principal. Possui uma excentricidade de 0.13020870 e uma inclinação de 6.06112º.

Este asteroide foi descoberto no dia 22 de setembro de 1990 por Eric Walter Elst em La Silla.

Ver também
 Lista de asteroides
 Asteroide da cintura principal

Ligações externas

Asteroides da cintura principal
Objetos astronômicos descobertos em 1990


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Hans Huber (1852 – 1921) – early works for orchestra and a world premiere recording
- the gentleman of Swiss Romantics
Swiss Romantic composer Hans Huber from Solothurn belonged to the big names of the Swiss music scene at the latest after his composition of the monumental festival "Kleinbasler Gedenkfeier" of 1892: before that, after studies with Carl Reinecke in Leipzig, he had first struggled through with smaller choral compositions and piano lessons in Alsace. The timing for his arrival in Basel was ideal: the music hall at the Steinenberg (today's Casino) had just been completed, followed shortly by the conservatory: Huber performed, composed, conducted and soon directed the music school and the conservatory, he was networked with all of Europe and gifted the culture-crazy citizens of Basel with chamber music, oratorios, nine symphonies and other works.
The new recoding of Schweizer Fonogramm offers French-greek conductor Yannis Pouspourikas a plateforme to dive into these marvellous orchestra pieces together with the Sinfonie Orchester Biel Solothurn . In addition to Huber's two serenades (Summer Nights and Winter Nights), the program includes the Comedy Overture op. 50 and – as a world premiere recording – the Roman Carnival, a humoresque for large orchestra. All works were composed between 1877 and 1895. Musicologist David Rossel traces the compositional process in the booklet, Frédéric Angleraux was responsible for the artistic direction of the recording with his studio ADCSound.
Buy on our shop
Complete symphonies by Joseph Lauber now available
3 CDs full of discoveries of Swiss Romantic Music
3 CDs for the price of 2 – the complete symphonic world premiere edition of Swiss composer Joseph Lauber's compositions have been highly praised by the international press. Kaspar Zehnder conducts the Sinfonie Orchester Biel Solothurn.


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Free Confederate States of America Essays and Papers
The Confederate States of America
The Confederate States of America A culture is the beliefs and interests of a particular group of people. About 150 years ago, a proud and noble culture was created in the Southern portion of the United States. It was created by Southerners from all walks of life, ranging from the gentry to the "good ol' boys." They loved their culture so much that they created a country. It was a country of blue skies, green hills, beautiful meadows and forests, and old-fashioned Southern hospitality. There
The Confederate States of America In February 1861 the American Southerners fearing for the crash of their economy, seceded from the Union. President Lincoln was elected in November of 1861 the Southerners knew their slaves would be abolished and their economy would collapse so they seceded. South Carolina was the first state to succeed from the Union. Ten other states soon followed the same path. The Confederate Army began the Civil War by seizing Fort Sumter in South Carolina, believing they
Confederate States Of America Confederate States of America, the name adopted by the federation of 11 slave holding Southern states of the United States that seceded from the Union and were arrayed against the national government during the American Civil War. Immediately after confirmation of the election of Abraham Lincoln as president, the legislature of South Carolina convened. In a unanimous vote on December 20, 1860, the state seceded from the Union. During the next two months ordinances
the streets of the abandoned Confederate capitol of Richmond in 1865. Although there are several different questions of why the North won the Civil War, factors involving manpower, economy, military tactics and leadership, and presidential leadership, are all parts of a puzzle historians have tried to put together for years. I believe that these four factors should prove to be the most powerful reasons for the Union's destruction of the Confederate States of America. The presidential leadership of
Was War Against The Confederate States of America Justified?
Schweikart, Larry, and Michael Allen. A Patriot's History of the United States: from Columbus's Great Discovery to the War on Terror. Reno, NV: Sentinel, 2004. Print. 289. [7] Schweikart, Larry, and Michael Allen. A Patriot's History of the United States: from Columbus's Great Discovery to the War on Terror. Reno, NV: Sentinel, 2004. Print. 288. [8] Schweikart, Larry, and Michael Allen. A Patriot's History of the United States: from Columbus's Great Discovery to the War on Terror. Reno, NV: Sentinel
The Civil War Of America
From 1861 to 1865 America was in a Civil War. The War was between the Confederacy and the Union and they were fighting over slavery. The Confederacy was made up of eleven states which who were fighting against the Union to have the right to still own slaves in the south. Once the confederates broke off from America they were known as the Confederate States of America. The rest of the other states where with the north and they were known as the Union. Once Lincoln was elected to be president without
weather or not the Civil War was fought over slavery or state rights. There were many violent events that occurred which led up to the civil war, starting rivals between the north and the south. According to Liscow's research (Liscow's,2010) there was more than just a single aspect to the start of the civil war. It was not purely economic nor was it purely about slavery. The article speaks of three possible motives. The first being that the United States wanted to stay ahead of foreign competition in the
The Emancipation Proclamation: The Confederate States Of The United States
keep slavery out of the territories, as a result the states in the south seceded and founded a new nation, the Confederate States of America. The government and most of the northern states refused to recognize the validity of their secession. They feared that the United States was going to drift apart and not be unified. They wanted to preserve the union at any cost. The civil war began
How Civil War Changed And Shaped The United States
Civil War Events The Civil War, the war that changed and shaped the United States. It made the U.S. what it is today. The change it made was exactly what the U.S. needed and it blew up from then. It has never been the same. In March 4, 1861 Abraham Lincoln was sworn in as the 16th president of the United States. Abraham was for the north and did not like slavery at all (Lincoln 1861). He fought against the south and cut off there trading ports so they would end up having a shortage of supplies
Abraham Lincoln's Assassination Research Paper
The Assassination of Abraham Lincoln On the evening of April 15, 1865, America lost one of the greatest presidents of all time. Abraham Lincoln was the sixteenth president of the united states. His most known accomplishment was writing the emancipation proclamation. The emancipation proclamation allowed all slave to be freed in the seceding states. He was assassinated by John Wilkes Booth in ford's theater during his second term in office. Abraham Lincoln's assassination was unjust because he was
Confederate States Army
Synecdoche
The Marriage of Heaven and Hell
Alan Ladd
Obituary poetry
The Celestial Omnibus
Julia A. Moore
Greek chorus
Legalized abortion and crime effect
The Impact of Legalized Abortion on Crime
Right to keep and bear arms
Dilation and evacuation
Intact dilation and extraction
Abortion law


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La grotte de Gournier est située près de Choranche dans le massif du Vercors. La cavité s'ouvre à 572 m d'altitude au pied de la falaise du plateau de Presles. Elle est une des exsurgences du massif des Coulmes et la grotte est considérée par de nombreux spéléologues comme la plus belle rivière souterraine des Alpes.

Historique
Oscar Decombaz en 1899 visite en barque le lac d'entrée. En 1947 une escalade au-dessus du lac par Jean Deudon permet d'accéder à la galerie fossile. Une équipe dont fait partie André Bourgin explore sur près de deux kilomètres cette galerie souvent concrétionnée. Deux accès sont découverts pour rejoindre la rivière sous-jacente. Elle est remontée jusqu'à une cascade de douze mètres en 1949. Cette dernière est franchie en 1952 par Pierre Chevalier et la rivière est suivie jusqu'à une grande salle. Dans les années 1960 le spéléo club de la Seine trouve la suite et s'arrête à la cote +  sur un siphon. Le spéléo club de Lyon en  franchit l'obstacle mais un deuxième siphon se présente. En 1974, il est plongé et en novembre 1975 à 5,3 kilomètres de l'entrée la cote +  est atteinte au pied d'une cascade de 5 mètres. En préparant une sortie pour passer l'obstacle en , trois spéléologues rhodaniens Michel Schmidt, Roland Chenevier et Daniel Trouilleux, sont emportés par une crue.

Le spéléo club de Dijon reprend les explorations en , et après la cascade de 5 mètres, 2200 mètres de galeries sont découvertes jusqu'à la cote + . En 1982 le terminus est atteint à + . Au-dessus de l'extrême amont des spéléologues creusent depuis plusieurs années des dolines en espérant rejoindre les galeries sous-jacentes.

Description
Le porche d'entrée donne sur un lac de 40 mètres de long. Au-dessus une galerie fossile de deux kilomètres, de 10 × 20 mètres de large, présente par endroits de beaux planchers stalagmitiques. Sous cette galerie quatre accès permettent d'atteindre la rivière souterraine. Une belle rivière avec cascades et plans d'eau peut être suivie jusqu'à la salle Chevalier. Après une partie complexe on peut retrouver la rivière. Le siphon Jérôme se présente mais on peut le passer à la nage. Un second siphon peut être évité puis la galerie devient grande avec une section de 20 × 20 mètres. On progresse dans une rue d'eau, l'Aquagalerie et à l'amont de la cascade de 5 mètres on poursuit la rivière. Après la salle des Burgondes la galerie devient plus grande puis le réseau devient méandriforme pour s'arrêter à + .

Géologie
La cavité se développe au contact Urgonien- Hauterivien. La rivière est creusée dans l'Hauterivien et les galeries fossiles dans l'Urgonien. Le réseau se développe sur une faille nord est-sud ouest. La galerie fossile a été vraisemblablement formée au Pliocène sous un climat subtropical, il y a 3-4 millions d'années. L'actif a été creusé lors des épisodes glaciaires du Riss II et du Würm.

Captage
Un captage pour alimenter le village de Presles a été envisagé en 1997 mais une autre solution a été trouvée.

Galerie

Notes et références

Notes

Références

Voir aussi

Bibliographie
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Articles connexes
 Massif du Vercors
 Spéléologie en France
 Liste des plus longues cavités naturelles
 gorges de la Bourne
 Liste des cavités naturelles les plus longues de l'Isère
 Gouffre Mirolda, baptisé du nom des trois victimes de la grotte

Liens externes
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Grotte en Isère
Grotte du massif du Vercors


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Posts Tagged 'bear/skin'
Culture Vulture: the year in review
Top Theater of 2015:
A View from the Bridge – Ivo van Hove's intense Broadway revival of Arthur Miller's, staged within Jan Verseweyveld's evocative stark set and lighting, an excellent cast headed by Mark Strong, Michael Gould, and Nicola Walker
Between Riverside and Crazy – I'm thankful that Second Stage brought back the Atlantic Theater Company's production of Stephen Adly Giurgis's deep, dark well-deserved Pulitzer recipient, full of amazing performances (Stephen McKinley Henderson and Liza Colon-Zayas – pictured below — with Ron Cephas Jones and Victor Almanzar) directed by Austin Pendleton.
An Octoroon – the kind of big, messy, important, risk-taking production that keeps me engaged with theater. Playwright Branden Jacobs-Jenkins had key collaborators in director Sarah Benson, eight brave actors, smart producers (Theatre for a New Audience extended the life of the show that began at Soho Rep), and a design team at the top of their game (especially Mimi Lien, who certainly deserves the MacArthur Foundation fellowship she won this year).
John (Signature Theatre) – Annie Baker's long astonishing play staged by Sam Gold on Mimi Lien's hyperrealistic set with four terrific performances: Georgia Engel, Lois Smith, Christopher Abbott, and Hong Chau.
Ghost Quartet – a sweet and haunting chamber piece from Dave Malloy (above, plaid shirt), composer of Natasha, Pierre, and the Great Comet of 1812, performed in the cozy setting of the bar at the McKittrick Hotel.
And That's How The Rent Gets Paid – Jeff Weiss (below) and Ricardo Martinez's East Village epic revived at the Kitchen featuring a cast of veteran and emerging downtown stars under director Brooke O'Harra's fine-tuned cat-herding.
iOW@ (Playwrights Horizons) — playwright Jenny Schwartz gave herself an amazing amount of freedom with this piece, one of the most aggressively odd-shaped plays I've ever seen in how information is delivered, how characters are introduced, how the story advances, the use of music (gorgeous and scrupulously unpredictable score by Todd Almond), etc. Kudos to director Ken Rus Schmoll and a super-game cast.
Composition…Master-Pieces…Identity (Target Margin Theater) – I don't know how he does it but David Greenspan again inhabited Gertrude Stein's prose with effortless genius.
Gloria (Vineyard Theatre) – another fine example of Branden Jacobs-Jenkins' gift for merging social commentary, shrewd humor, and extraordinary performance opportunities; Evan Cabnet directed the fantastic six-member cast, among whom Jennifer Kim and Ryan Spahn stood out for me.
Hamilton (Public Theatre) – I had my reservations about the most acclaimed musical of the year (the hiphop score is monotonous, the staging is theatrically square, and author Lin-Manuel Miranda's performance struck me as charmless) but there's no denying that this retelling of early American history by black and Latino performers is smart, conceptually ambitious, and fiendishly well-written.
Steve (New Group) – Mark Gerrard's smart, hilarious gay comedy about sad stuff, impeccably directed by Cynthia Nixon with a fine cast and a seriously great performance by Matt McGrath.
Eclipsed (Public Theatre)– Danai Gurira's original play about the experience of women during Liberia's civil war with an exceptional all-female ensemble directed by Liesl Tommy
Ada/Ava (3Legged Dog) – unusual, inventive, emotionally absorbing shadow puppet play created by the Chicago-based Manual Cinema
Spring Awakening – DeafWest Theatre's revelatory revival of Duncan Sheik and Steven Sater's musical adaptation of Frank Wedekind's play with a cast full of impressive Broadway newcomers directed by Michael Arden, noteworthy set by Dane Laffrey.
Grounded (Public Theater) – Julie Taymor brought her theatrical magic to this small honest play starring Anne Hathaway (below) as a disillusioned and war-damaged drone pilot
Preludes (LCT3) – another exceptional eccentric musical event from the team of composer Dave Malloy and director Rachel Chavkin starring Gabriel Ebert (below, with flowers) on another dazzling Mimi Lien set.
Disgraced – Ayad Akhtar's play superbly directed on Broadway by Kimberly Senior.
Living Here (Foundry Theatre) — Gideon Irving's one-man musical performed in living rooms all over NYC (including mine)
Raul Esparza in Cymbeline in Central Park
Keith Hennessy's bear/SKIN in the Abrons Arts Center's American Realness Festival
Bob Crowley's sets and costumes and Robert Fairchild's performance in An American in Paris
Daniel Oreskes, Cameron Scoggins, and Tom Phelan in Taylor Mac's Hir at Playwrights Horizons with a set by David Zinn that screamed "toxic America"
Other Culture Vulture High Points:
South African photographer Zanele Muholi's show Isibonelo/Evidence at the Brooklyn Museum
Anna Teresa de Keersmaker's Partita in the White Light Festival
The new Whitney Museum
Habeas Corpus, Laurie Anderson's collaboration with Guantanamo Bay detainee Mohammed el Gharani at the Park Avenue Armory
Love and Mercy, Bill Pohlad's harrowing, arty, moving, thrilling biopic of Brian Wilson with an incredible performance by Paul Dano – my favorite film of the year
Posted in Culture Vulture | Leave a Comment »
Tags: a view from the bridge, ada/ava, an octoroon, and that's how the rent gets paid, anne hathaway, annie baker, bear/skin, between riverside and crazy, bill pohlad, branden jacobs-jenkins, dani gurira, dave malloy, david greenspan, David Zinn, disgraced, eclipsed, ghost quartet, gideon irving, gloria, grounded, hamilton, iow@, ivo van hove, john, julie taymor, keith hennessy, kimberly senior, living here, love and mercy, mark gerrard, michael arden, preludes, rachel chavkin, raul esparza, spring awakening, steve, zanele muholi
Culture Vulture: Chris Ofili's NIGHT AND DAY and Keith Hennessy's bear/SKIN
My expedition to the Lower East Side began at the New Museum to see "Night and Day," the first retrospective in New York City of paintings by Chris Ofili, the artist of Nigerian descent who was born in London and currently resides in Trinidad. I was very keen to see the show because I'd heard so much about Ofili's work, and Calvin Tompkins' profile of him in the New Yorker recently also whetted my appetite. The show takes up three floors of the New Museum, and the work on the second floor captivated me the most — large, textured, sexy brightly colored witty canvases with other materials collaged in with the paint. They're definitely worth seeing in person, close up.
Of course, Ofili gained some notoriety in New York in 2005 when a work of his called "The Holy Virgin Mary" appeared in a group show at the Brooklyn Museum and was attacked, sight unseen, by Mayor Rudy Giuliani as blasphemous, based on sensationalized descriptions of the piece in the tabloid press. One of Ofili's key materials is elephant dung — he uses dried balls of it like furniture legs to rest many of his large canvases on, and one of the Virgin Mary's breasts was represented by a similar clump of elephant dung. That whole controversy was an embarrassing episode for New York City and Giuliani, and "Night and Day" frames it beautifully by standing "The Holy Virgin Mary," a somewhat provocative young man's piece, far from Ofili's finest work, next to a very strong piece called "No Woman No Cry."
Taking its title from the Bob Marley song, the painting was inspired by yet another episode of a young black man killed by police in London many years ago. You can see here that the mother's necklace and the footrests for the painting are all made of…well, I realize that in the course of Brooklyn Museum controversy the press learned to refer to the material as "dung," a polite word that can be printed in family newspapers. But one of the pieces in "Night and Day" explains how early in his career Ofili made an installation/performance on the street in London selling what he explicitly labeled "Elephant Shit." At the New Museum we see a tiny little piece called "Shithead," featuring elephant shit with baby's teeth and some clumps of Ofili's own hair turning it into a grinning scheisskopf. So all along, Ofili's attitude about the stuff has been witty, not just folkloric. On the second floor there are several canvases depicting a black action hero he invented named Captain Shit. I very much enjoyed this ghostly/amusing one called The Naked Spirit of Captain Shit and the Legend of the Black Stars:
His female figures are fierce, voluptuous goddesses — my favorite is simply titled She:
Strangely, the lighting for this exhibition is shockingly poor — the strong overhead lighting casts a lot of glare on the canvases. On the third floor is a room of recent very dark paintings that are almost impossible to see anyway, and the lighting makes the experience of communing with them worse. On the fourth floor are a series of paintings inspired by Ovid's Metamorphoses, less interesting to me than this piece called Lime Bar, which includes an Ofili self-portrait (apparently in Trinidad he bartends part-time at a friend's bar):
I was fascinated by Ofili's rendition of the Anunciation, a huge sculpture with a black angel and a gold Madonna, fused at the mouth like Rodin's famous sculpture The Kiss:
On the fifth floor is a small sidebar, "When Shadows Were Shortest," about Ofili's sets and costumes for an opera based on the myth of Diana and Acteon — I loved this costume for a shadowy hound-creature :
Afterwards, we went for a quick tasty bite at Pearl & Ash, the cozy wine bar right across the street on the Bowery.
Then it was time to mosey down to the Abrons Arts Center to see the opening night of my friend Keith Hennessy's Bear/Skin in the American Realness festival. Born in Canada and based primarily in San Francisco, Hennessy is a highly skilled dancer, performance artist, and nouveau cirque acrobat; he is also a veteran social activist, community organize, and now credentialed art historian, so his work tends to incorporate an unusual density of verbal commentary and visual imagery. In the American Realness catalogue, here's the description: "Motivated by grand spectacle and ambitious prayer, Bear/Skin appropriates Nijinsky's choreography for Le Sacre du Printemps (1915) to consider Modernism's dependence on appropriations of the indigenous, folk, exotic and oriental to ask questions about ritual and art today." But no such summary does justice to the collage that Hennessy performs or the relentless intellectual dance he does, introducing theoretical points of view and critiquing them at the same time. He starts with a poem about action movies as "medicine," riffing on the screen depiction of violence against cops as both a cathartic response to real-life police brutality and a heroic mythology. While seeming to be very casual about it, Hennessy sets up the conditions for a pagan performance ritual, donning a bear suit in such a way that conjures images both of ancient shaman and contemporary urban homeless person. There's an extended verbal commentary about "the economy of suicide," as it disproportionately impacts the young, the elderly, and the military. Setting up his laptop for occasional glancing reference, Hennessy duplicates a section of Nijinsky's original choreography for Le Sacre du Printemps. Then he changes into an elaborate multilayered costume — a three-minute interval during which the audience is invited to commune with one another under the kind of mylar space blankets marathon runners and park-bench sleepers use to warm themselves — to do an entirely invented sort of shamanic ritual dance of transformation.
Afterwards we had dinner in the warm basement of Galli on Rivington Street and talked about the show and its many sources and layers.
wallpaper in the bathroom at Galli
Tags: american realness, bear/skin, chris ofili, galli, keith hennessy, new museum, night and day, pearl & ash


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Gervonta Davis Spotted Grinding on Ariana Fletcher on the Street After Claiming They Break Up Wiki Biography
"He landed his first US TV music show, "Jamie Foxx: Unpredictable," set to be televised on NBC on January 25, 2006, as his se...
"He landed his first US TV music show, "Jamie Foxx: Unpredictable," set to be televised on NBC on January 25, 2006, as his second song, "Unpredictable," Jamie Foxx quickly discovered the highlight of his singing career, growing to take the top spot on The Billboard 200, then directing him to become the fourth Academy Award candidate and making a number one album o. o. o. With roles in a string of high-profile film performances, including "Miami Vice" (2006),
"Dreamgirls" (2006), "Damage Control" (2007), "The Kingdom" (2007), plus "Blood on the Leaves" as one of the speakers at the coveted 63rd annual Golden Globe Awards on January 16, 2007, this charismatic star is predicted to proceed to deliver another performance (2007).
He was appointed Eric Morlon Bishop in Terrell, Texas, on December 13, 1967, and is referred to by people as the American actor Jamie Foxx. Let Foxx be adopted by her parents, Mark and Esther Talley, in order to leave her boyfriend, his mother Loise, when he was just seven months old. At the age of three, at the urging of his grandma, Foxx, who was able to play the piano, initiated his first piano lessons.
As he was growing up, Foxx went to high school, played quarterback for his high school squad, and he was successful enough to gain press from Dallas newspapers. He moved on to college and entered Julliard in order to begin learning music, to learn classical piano, where he received a music scholarship. Foxx spent two years studying at the United States International University, which is now known as the Alliant International University, from 1986 to 1988, following graduation.
His passion for music eventually resulted in his first solo album "Peep This" released in 1994, before he performed the theme song for his movie "Any Given Sunday." in 1999. Music aside, Foxx, who was so good at cracking tales that he was used as a compliment by his instructor in the second grade, has just set up his career by being a stand up comic. Since a girlfriend of his had convinced him to do so, he created his first appearance on stage in 1989. And so Foxx came to the Comedy Club and took the term 'androgynous' because he learned that on open stage evenings, women had a micro-time preference. "Roc"Roc"In Living Color"In Living Colour (1990).
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Justia Patents Organic Compounds -- Part Of The Class 532-570 Series Patents Organic Compounds (class 532, Subclass 1)Heterocyclic Carbon Compounds Containing A Hetero Ring Having Chalcogen (i.e., Oxygen, Sulfur, Selenium Or Tellurium) Or Nitrogen As The Only Ring Hetero Atoms Patents The Hetero Ring Contains Seven Members Including Nitrogen And Carbon Patents Spiro Patents (Class 540/543)
Spiro Patents (Class 540/543)
Reduction of HMF ethers with metal catalyst
Abstract: Methods of making reduced derivatives of hydroxymethyl furfural using metal catalysts are described. The derivatives may have tetrahydrofuran or furan nucleus with alkoxymethyl ether or ester moieties on the 5? carbon and methanol on the 2? carbon. Suitable metal catalyst include Raney nickel, a nickel catalyst with a zirconium promoter, a chromite catalyst with a barium, a palladium catalyst, such as palladium on carbon, or a ruthenium catalyst. Also provided are a new class of compounds, which are n-alkoxy hexane diols (i.e., 1,2 or 1,5 hexane diol ethers) and methods of making the same by reduction of furan or tetrahydrofuran derivatives.
Assignee: Archer Daniels Midland Co.
Inventors: Paul Bloom, Alexandra Sanborn
Assignee: Archer Daniels Midland Company
Bromodomain inhibitors and uses thereof
Abstract: The present invention relates to compounds useful as inhibitors of bromodomain-containing proteins. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
Assignee: Constellation Pharmaceuticals, Inc.
Inventors: Brian K. Albrecht, James Edmund Audia, Alexandre Côté, Victor S. Gehling, Jean-Christophe Harmange, Michael Charles Hewitt, Christopher G. Nasveschuk, Alexander M. Taylor, Rishi G. Vaswani
BENZO [B] ISOXAZOLOAZEPINE BROMODOMAIN INHIBITORS AND USES THEREOF
Inventors: Brian K. Albrecht, Victor S. Gehling, Alexander M. Taylor, Rishi G. Vaswani
PYRAZOLE INDANYL CARBOXAMIDES
Abstract: The present invention relates to novel 1-methyl-pyrazole(thio)indanyl carboxamides, to processes for preparing these compounds, to compositions comprising these compounds, and to the use thereof as biologically active compounds, especially for control of harmful microorganisms in crop protection and in the protection of materials.
Applicant: Bayer Cropscience AG
Inventors: Pierre-Yves Coqueron, Mazen Es-Sayed, Simon Maechling, Pierre Wasnaire, Peter Dahmen, Ulrike Wachendorff-Neumann, David Bernier, Lionel Carles, Christophe Dubost, Stephane Brunet, Helene Lachaise, Jean-Pierre Vors
AMIDO-BENZYL SULFONE AND SULFOXIDE DERIVATIVES
Abstract: The present invention relates to certain amido-benzyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.
Inventors: Kenneth W. Bair, Timm R. Baumeister, Alexandre J. Buckmelter, Karl H. Clodfelter, Peter Dragovich, Francis Gosselin, Janet Gunzner-Toste, Bingsong Han, Jian Lin, Xiongcai Liu, Dominic J. Reynolds, Chase C. Smith, Zhongguo Wang, Mark Zak, Yamin Zhang, Guiling Zao, Xiaozhang Zheng, Po-Wai Yuen
ISOXAZOLINES AS INHIBITORS OF FATTY ACID AMIDE HYDROLASE
Abstract: The present invention provides isoxazoline FAAH inhibitors of the formula (I): or pharmaceutically acceptable forms thereof, wherein each of G, Ra, Rb, Rc, and Rd are as defined herein. The present invention also provides pharmaceutical compositions comprising a compound of formula (I), or a pharmaceutically acceptable form thereof, and a pharmaceutically acceptable excipient. The present invention also provides methods for treating an FAAH-mediated condition comprising administering a therapeutically effective amount of a compound of formula (I), or pharmaceutically acceptable form thereof, to a subject in need thereof.
Inventors: Mark L. BEHNKE, Alfredo C. CASTRO, Lawrence K. CHAN, Catherine A. EVANS, Louis GRENIER, Michael J. GROGAN, Yves LEBLANC, Tao LIU, Stephane PELUSO, Daniel A. SNYDER, Thomas T. TIBBITTS
PYRROLOPYRIMIDINE COMPOUNDS AS INHIBITORS OF CDK4/6
Abstract: The invention is directed to novel pyrrolopyrimidine compounds of formula (1) wherein R1, R2y, R4, R8-R11, A and L are defined herein and to salts, including pharmaceutically acceptable salts thereof. The compounds of the present invention are CDK4/6 inhibitors and could be useful in the treatment of diseases and disorders mediated by CDK4/6, such as cancer, including mantle cell lymphoma, liposarcoma, non small cell lung cancer, melanoma, squamous cell esophageal cancer and breast cancer. The invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting CDK4/6 activity and to the treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
Applicant: NOVARTIS AG
Inventors: Christopher Thomas BRAIN, Young Shin CHO, John William GIRALDES, Bharat LAGU, Julian Roy LEVELL, Michael Joseph LUZZIO, Lawrence Blas PEREZ, Yaping WANG, Fan YANG
Spirocyclic derivatives as histone deacetylase inhibitors
Abstract: This invention is related to new histone deacetylase inhibitors according to the general formula (I), wherein: m and n are independently zero or an integer from 1 to 4; p is zero or an integer from 1 to 3, with the proviso that when p is zero, n and m cannot be both 1; R is hydrogen; C1-C6 alkyl, optionally substituted by C3-C8 cycloalkyl, C6-C10 aryl or hetero(C2-C9)aryl; (CO)R2; (SO2)R3; C3-C8 cycloalkyl; C6-C10 aryl; or hetero(C2-C9)aryl; R1 is halogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy; Y is CH2 or NR4; Z is C?R5; and R2, R3, R4, and R5 are as further defined in the specification; and pharmaceutical acceptable salts thereof.
Assignee: DAC S.R.L.
Inventors: Mario Varasi, Florian Thaler, Raffaella Amici, Agnese Abate, Maria Carmela Fulco, Saverio Minucci, Ciro Mercurio
Electrolyte synthesis for ultracapacitors
Abstract: A method of forming an electrolyte solution involves combining ammonium tetrafluoroborate and spiro-bi-pyrrolidinium bromide in a liquid solvent to form spiro-bi-pyrrolidinium tetrafluoroborate and an ammonium halide. The ammonium halide precipitate is removed from the solvent to form an electrolyte solution. The reactants can be added step-wise to the solvent, and the method can include using a stoichiometric excess of the ammonium tetrafluoroborate to form a substantially halide ion-free electrolyte solution.
Assignee: Corning Incorporated
Inventors: Kishor Purushottam Gadkaree, Satyanarayana Kodali, Obiefuna Chukwuemeka Okafor, Shivani Rao Polasani
SPIROPYRROLIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
Abstract: The present invention is directed to spiropyrrolidine compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
Applicant: Merck Sharp & Dohme Corp.
Inventors: Kun Liu, Shawn J. Stachel, Craig A. Coburn, Thomas G. Steele, Richard Soll, Hao Wu, Xuanjin Peng, Yaxian Cai, Xiaoxiang Du, Jian Li
HIGHLY SELECTIVE SIGMA RECEPTOR LIGANDS
Abstract: Compounds having the general formula II, III, or IV wherein R1 can be a radical of an optionally substituted C-4 to C-7 N-containing heterocycle or a radical of an optionally substituted cyclic or acyclic tertiary amine or isoindoline-1,3-dione: R2,3,4,5,6 can each independently be any one or combinations of the following moieties, cyano, nitro, acyl, alkyl, amido, azido, isothiocyanate, isocyanate, optionally substituted anilino, halogens, ethers, sulfonamides, thioacyl, nitro, aromatic, heterocyclic, olefinic, acetylene, deuterium, or tritium; Y can be either CH, CH2, O, S, OCH2, N—R, N—Ar, C—R, C—Ar; Z can be either H, O, S, S—R or NR.
Inventors: Christopher R. MCCURDY, Christophe Mesangeau, Bonnie Ann Avery, Ahmed Hassan Amin Abdelazeem, Frederick T. Chin, Jacques Henri Poupaert
Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their use and Manufacture
Abstract: The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.
Applicant: Exelixis, Inc.
Inventor: Kenneth D. Rice
Spirocyclic aminoquinolones as GSK-3 inhibitors
Abstract: Provided herein are spirocyclic aminoquinolones of formula I and compositions containing the compounds. The compounds and compositions provided herein are useful in the prevention, amelioration or treatment of GSK-3 inhibitors mediated diseases.
Assignee: Kyorin Pharmaceutical Co., Ltd.
Inventors: Oana Cociorva, Yasumichi Fukuda, Yasushi Kohno, Bei Li, Kyoko Okada, Ayako Nakamura, Masahiro Nomura, Shigeki Seto, Anna Katrin Szardenings, Kazuhiro Yumoto
Applicant: Sunovion Pharmaceuticals Inc.
Inventors: Larry Wendell Hardy, Michele L.R. Heffernan, Frank Xinhe Wu, Lakshmi D. Saraswat, Kerry L. Spear
Assignee: Merck Sharp & Dohme Corp.
PHARMACEUTICAL COMPOUNDS
Abstract: Benzimidazoles of formula (I): wherein: A is 5- to 12-membered aryl or 5- to 12-membered heteroaryl, each of which is unsubstituted or substituted; Y is a single bond, —(CH2)p—, —X—, —CH2—X—, or —X—CH2—; X is —O—, —S—, —N(R2)—, >C?O, >S(?O), >S(?O)2, —O—C(?O)—, —C(?O)—O—, N(R2)—C(?O)—, or —C(?O)—N(R2)—; each L is independently a single bond, C1-3alkylene, C2-3alkenylene or C2-3alkynylene; R1 is C1-6alkyl, C2-6alkenyl or C2-6alkynyl, each of which is unsubstituted or substituted; each Z is independently —N(R2)2, —OR2, —SR2, —S(?O)R2, —S(?O)2R2; each R2 is independently hydrogen, C1-6alkyl, C2-6alkenyl or C2-6 alkynyl, wherein said alkyl, alkenyl and alkynyl groups are unsubstituted or substituted; m is 0, 1, 2, or 3; n is 1, 2, or 3; and p is 1, 2, or 3; and the pharmaceutically acceptable salt thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection.
Applicant: re: Viral Ltd
Inventors: Stuart Cockerill, Christopher Pilkington, James Lumley, Richard Angell, Neil Mathews
Uses of substituted imidazoheterocycles
Abstract: The present invention provides a method of prophylaxis, treatment or inhibition of a cannabinoid receptor-associated disease, disorder or condition in a mammalian subject, the method comprising administering to the subject a compound having the structure of formula I or a pharmaceutically acceptable salt, acid salt, hydrate or stereoisomer thereof, wherein the cannabinoid receptor-associated disease, disorder or condition is pain or an inflammatory disease, disorder or condition, and wherein formula I is as follows: wherein Rb, Rc, Z, Y and m are defined in the specification.
Assignee: Cara Therapeutics, Inc.
Inventors: R. Paul Beckett, Richard Foster, Christelle Henault, Janet L. Ralbovsky, Carla M. Gauss, Gary G. Gustafson, Zhiyong Luo, Ann-Marie Campbell, Tatiana E. Shelekhin
Spiro-condensed indoline derivatives as pesticides
Abstract: The use of a compound of formula I wherein Y is a single bond, C?O, C?S or S(O)m where m is 0, 1 or 2; R1, R2, R3, R4, R8 and Ra are specified organic groups and p is 0, 1, 2, 3, 4, 5 or 6; q is 0, 1, 2, 3, 4, 5 or 6; provided that when p is 2 then q is not 2; p+q is 1, 2, 3, 4, 5 or 6; or salts or N-oxides thereof or compositions containing them and their using incontrolling insects, acarines, nematodes or molluscs. Novel compounds are also provided.
Assignee: Syngenta Crop Protection LLC
Inventors: Jerome Yves Cassayre, Louis-Pierre Molleyres, Peter Maienfisch, Fredrik Emil Malcolm Cederbaum
CGRP RECEPTOR ANTAGONISTS
Abstract: Compounds of Formula I: (wherein variables A1, A2, A3, ring-B, m, n, J, E1, E2, E3, R5, RPG and Y are as described herein), which are useful as antagonists of CGRP receptors, and useful in the treatment or prevention of diseases in which CGRP receptors are involved, such as headache, and in particular migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising the compounds of formula (I) and the use of these compounds and compositions in the prevention or treatment of diseases in which CGRP receptors are involved.
Inventors: Craig A. Stump, Amy G. Quigley, Cory R. Theberge, Michael R. Wood
BROMODOMAIN LIGANDS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME
Abstract: Described herein are monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g. in vivo) to form a multimer (e.g. a dimer). Contemplated monomers may include a ligand moiety, a linker element, and a connector element that joins the ligand moiety and the linker element. In an aqueous media, such contemplated monomers may join together via each linker element and may thus be capable of modulating one or more biomolecules substantially simultaneously, e.g., modulate two or more binding domains on a protein or on different proteins.
Applicant: Coferon, Inc.
Inventors: Lee Daniel Arnold, Kenneth W. Foreman, Douglas S. Werner
Abstract: A compound useful for treating subjects in need of therapy involving sigma receptors or for alleviation of affects resulting from drug abuse having the general formula I in which R1 can be a radical of an optionally substituted C-4 to C-7 N-containing heterocycle such as, for example, radicals of optionally substituted piperidines, optionally substituted piperazines, optionally substituted tetrahydropyridines, optionally substituted azepanes, tertiary amines (cyclic or acyclic), isoindoline-1,3-dione, or optionally substituted tetrahydroisoquinolones (aromatically substituted): R2,3,4,5,6 can each independently be any one or combinations of the following moieties, cyano, nitro, acyl, alkyl, amido, azido, isothiocyanate, isocyanate optionally substituted anilino, halogens, ethers, sulfonamides, thioacyl, nitro, aromatic, heterocyclic, olefinic, acetylene, deuterium, or tritium; Y can be either CH, CH2, O, S, OCH2, N—R, N—Ar, C—R, C—Ar; Z can be either H, O, S, S—R or NR.
Assignees: The University of Mississippi, L'Universite Catholique de Louvain
Inventors: Christopher R. McCurdy, Christophe Mesangeau, Sanju Narayanan, Rae Reiko Matsumoto, Jacques Henri Poupaert
6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepines
Abstract: The invention relates to 6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepines, in particular for therapeutic purposes, pharmaceutical agents and use thereof in therapy, in particular for the prevention and treatment of tumour diseases.
Applicant: BAYER INTELLECTUAL PROPERTY GMBH
Inventors: Norbert Schmees, Joachim Kuhnke, Bernard Haendler, Philip Lienau, Amaury Ernesto Fernandez-Montalvan, Pascale Lejeune, Stephan Siegel, William Scott
Pyridine and pyrimidine based compounds as Wnt signaling pathway inhibitors for the treatment of cancer
Abstract: The present invention relates to pyridine and pyrimidine based compounds, pharmaceutical compositions comprising these compounds and their potential use as therapeutic agents for the treatment and/or prevention of cancer.
Assignee: Cancer Research Technology Ltd.
Inventors: Edward McDonald, Julian Blagg, Mark Pichowicz, Simon Ross Crumpler
AZA Spiro Alkane Derivatives as Inhibitors of Metalloproteases
Abstract: The present invention provides a compound of Formula I or Formula II: enantiomer, diastereomer, prodrug, solvate, metabolite, or pharmaceutically acceptable salt thereof, wherein constituent variables are provided herein. The compounds of Formula I and II are modulators of metalloproteases and are useful in treating diseases associated with metalloprotease activity such as arthritis, cancer, cardiovascular disorders, skin disorders, inflammation and allergic conditions.
Applicant: INCYTE CORPORATION
Inventors: Wenqing Yao, Jincong Zhuo, Meizhong Xu, Fenglei Zhang, Brian W. Metcalf
DIOXIRANE COMPOUNDS AND USES THEREOF
Abstract: A dioxirane-containing compound has a first substituent that is an alkyl, polyalkoxy, aryl, heteroaryl, or heterocyclyl group, and a second substituent that is an electron withdrawing group, and where the first and second substituents can optionally join to form a cycloalkyl or heterocyclyl group. The dioxirane-containing compound can be used as an oxidant, surfactant, and/or an ionic liquid.
Inventor: Kraig ANDERSON
NITROGEN-CONTAINING SPIROCYCLIC COMPOUNDS AND PHARMACEUTICAL USES THEREOF
Abstract: A compound of the following general formula [I]: wherein each symbol has the same meaning as defined herein, or a pharmaceutically acceptable salt thereof, or a solvate thereof, and a pharmaceutical use of the same in treating organ transplant rejection, graft versus host reaction after transplantation, autoimmune disease, allergic disease and chronic myeloproliferative disease.
Applicant: Japan Tobacco Inc.
Inventors: Satoru Noji, Makoto Shiozaki, Tomoya Miura, Yoshinori Hara, Hiroshi Yamanaka, Katsuya Maeda, Akimi Hori, Masafumi Inoue, Yasunori Hase
HETEROCYCLIC NUCLEAR HORMONE RECEPTOR MODULATORS
Abstract: The invention provides a compound of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
Applicant: ABBVIE INC.
Inventors: Kevin P. Cusack, Thomas D. Gordon, Michael Z. Hoemann, David C. Ihle, Bin Li, Gloria Y. Lo Schiavo, Gagandeep K. Somal, Michael Friedman, Martin E. Hayes, Wouter Iwema Bakker
METABOTROPHIC GLUTAMATE RECEPTOR 5 MODULATORS AND METHODS OF USE THEREOF
Abstract: Compounds that modulate GluR5 activity and methods of using the same are disclosed.
Inventors: Michele L. R. Heffernan, Larry Wendell Hardy, Frank Xinhe Wu, Lakshmi D. Saraswat, Kerry L. Spear
Photochromic material
Abstract: The present invention is a photochromic material formed of a biimidazole compound represented by general formula (1-1): (where, R4 and R5 respectively and independently represent a halogen atom or alkyl group, R1 to R3 and R6 to R8 respectively and independently represent a hydrogen atom, halogen atom, alkyl group, fluoroalkyl group, hydroxyl group, alkoxyl group, amino group, alkylamino group, carbonyl group, alkylcarbonyl group, nitro group, cyano group or aryl group, Ar1 to Ar4 respectively and independently represent a substituted or unsubstituted aryl group, R4 may form a condensed, substituted or unsubstituted aryl ring with R3, and R5 may form a condensed, substituted or unsubstituted aryl ring with R6).
Assignee: Mitsubishi Gas Chemical Company, Inc.
Inventors: Takeru Horino, Atsuhiro Tokita, Toyoji Oshima
CHEMICAL COMPOUNDS 542
Abstract: The present invention relates to compounds of Formula (I): to pharmaceutically acceptable salts thereof, to methods of using them to treat bacterial infections, and to methods for their preparation.
Applicant: ASTRAZENECA AB
Inventors: Kevin BARVIAN, Gregory Steven BASARAB, Madhusudhan Reddy GOWRAVARAM, Sheila Irene HAUCK, Fei ZHOU
Abstract: The invention relates to an ionic liquid composition and a method for preparing the ionic liquid. The ionic liquid comprises a cation containing the Formula I, as herein disclosed, and wherein: n is 2, R1 is selected from the group consisting of: H, C1-C12 alkyl, aryl or together with R2 may form a heterocyclic ring, and R2 is selected from the group consisting of: H, C1-C12 alkyl, aryl or together with R1 may form a heterocyclic ring, and R3 is selected from the group consisting of hydrogen and C1-C12 alkyl, and wherein R1 and R2 are not simultaneously selected from hydrogen.
Assignee: Invista North America S.A R.L.
Inventors: Stewart Forsyth, Kenneth Richard Seddon, Keith Whiston
TRICYCLIC QUINOLINE AND QUINOXALINE DERIVATIVES
Abstract: The present invention relates to tricyclic quinoline and quinoxaline derivatives, to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT2C receptor, their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of 5-HT2C receptor, and to a method for preventing or treating conditions and disorders which respond to the modulation of 5-HT2C receptor.
Inventor: Wilfried Braje
NOVEL BICYCLIC NITROGEN CONTAINING HETEROARYL TGR5 RECEPTOR MODULATORS
Abstract: Novel compounds of Formula I:or an enantiomer, diastereomer, tautomer, prodrug or salt thereof, wherein m, Q, T, U, V, ring A, X, Y, R3, R4, R4a, R5a, R5b, R5c, R5d, R5e, R6a, R6b, and R6c are defined herein, are provided which are TGR5 G protein-coupled receptor modulators. TGR5 G protein-coupled receptor modulators are useful in treating, preventing, or slowing the progression of diseases requiring TGR5 G protein-coupled receptor modulator therapy. Thus, the disclosure also concerns compositions comprising these novel compounds and methods of treating diseases or conditions related to the activity of the TGR5 G protein-coupled receptor by using any of these novel compounds or a composition comprising any of such novel compounds.
Inventors: Jeffrey A. Robl, Jun Li, Lawrence J. Kennedy, Steven J. Walker, Haixia Wang, William N. Washburn, Saleem Ahmad, Khehyong Ngu
Substituted Benzoazepines As Toll-Like Receptor Modulators
Abstract: Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, fibrotic disease, cardiovascular disease, infectious disease, inflammatory disorder, graft rejection, or graft-versus-host disease.
Inventors: James Jeffry Howbert, Robert Hershberg, Laurence E. Burgess, Hong Woon Yang
6,7,8,9-Tetrahydro-5H-1,4,7,10a-tetraaza-cyclohept[f]indene derivatives, pharmaceutical compositions containing these compounds, their use and processes for preparing them
Abstract: The present invention relates to compounds defined by formula I wherein the groups X, Y, W and R1 to R4 are defined as in claim 1, possessing valuable pharmacological activity. Particularly the compounds are agonists of the 5-HT2C receptor, and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this receptor, such as metabolic and CNS-related disorders.
Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Inventors: Stephan-Georg MUELLER, Christopher John BROWN, Alexander HEIFETZ, Bernd NOSSE, Juergen PRESTLE, Natacha PREVOST, Klaus RUDOLF, Stefan SCHEUERER, Marcus SCHINDLER, Dirk STENKAMP, Leo THOMAS, Heather TYE
5-Amino-Oxazepine and 5-Amino-Thiazepane Compounds as Beta Secretase Antagonists and Methods of Use
Abstract: The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula (I); wherein variables A1, A3, A4, A5, A6, A8, R2, R7, X and Y of Formula (I) are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas (II) and sub-formula embodiments of Formula (I) and (II), intermediates and processes and methods useful for the preparation of compounds of Formulas (I)-(II).
Applicant: AMGEN INC.
Inventors: Thomas Dineen, Matthew Weiss, Vinod F. Patel, Xiao Mai Zheng, Ryan White
Azinone-substituted azepino[]indole and pyrido-pyrrolo-azepine MCH-1 antagonists, methods of making, and use thereof
Abstract: Novel MCH-1 receptor antagonists are disclosed. These compounds are used in the treatment of various disorders, including obesity, anxiety, depression, non-alcoholic fatty liver disease, and psychiatric disorders. Methods of making these compounds are also described in the present invention.
Assignee: Albany Molecular Research, Inc.
Inventors: Peter R. Guzzo, Matthew David Surman, James Francis Grabowski, Jr., Emily Elizabeth Freeman
INHIBITORS OF THE INFLUENZA A VIRUS M2 PROTON CHANNEL
Abstract: Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds that have been identified as being capable of interaction with the M2 protein.
Applicant: The Trustees of The University Of Pennsylvania
Inventors: WILLIAM F. DeGRADO, JUN WANG
INDOLE DERIVATIVES USEFUL AS CCR2 ANTAGONISTS
Abstract: Disclosed are the CCR2 antagonists of Formula I: I or pharmaceutically acceptable salt thereof wherein R7, A, X, B, and n are defined herein. Also disclosed are pharmaceutical compositions containing the compounds, methods of treatment using the compounds, and compositions to treat diseases or disorders associated with CCR2 activity.
Inventors: Anilkumar G. Nair, Joseph A. Kozlowski, Jose S. Duca, Stuart B. Rosenblum
Applicant: KYORIN PHARMACEUTICALS CO., LTD.
Applicant: CONSTELLATION PHARMACEUTICALS
Inventors: Brian K. Albrecht, James Edmund Audia, Alexandre Cote, Victor S. Gehling, Jean-Christophe Harmange, Michael Charles Hewitt, Christopher G. Naveschuk, Alexander M. Taylor, Rishi G. Vaswani
Inhibitors of hepatitis C virus
Abstract: A class of compounds that inhibit Hepatitis C Virus (HCV) is disclosed, along with compositions containing the compound, and methods of using the composition for treating individuals infected with HCV.
Assignee: Presidio Pharmaceuticals, Inc.
Inventors: Min Zhong, Leping Li
3-Spirocyclic Piperidine Derivatives as Ghrelin Receptor Agonists
Abstract: The invention relates to derivatives of formula (I), wherein the substituents are as defined in the specification; to processes for the preparation of such derivatives; pharmaceutical compositions comprising such derivatives; such derivatives as a medicament; such derivatives for the treatment of a disorder or a disease mediated by the ghrelin receptor.
Inventors: Ameet Vijay Ambarkhane, Gurdip Bhalay, Martin Beckett, James Dale, Ahmed Hamadi, Alessandro Mazzacani, Jeffrey McKenna, Christopher Thomson
Applicant: Presidio Pharmaceuticals, Inc.
Cephalotaxane derivatives and their processes of preparation and purification
Abstract: The present invention concerns a new general process for asymmetric hemisynthesis of harringtonines and their analogs, that are alkaloids used in chemotherapy. This process comprises direct esterification of a natural cephalotaxine with an acylating compound constituted of a side chain precursor which backbone and functionalization are entirely preformed. The invention also concerns a natural, synthetic or semi-synthetic harringtonines including their tautomeric forms and their salts of the following formula: wherein n=2 (i.e. harringtonine) or n=3 (i.e. homoharringtonine), in which the total content of impurities, possibly including enantiomeric forms, is lower than 1%, and/or the content of the major impurity is lower than 0.9%, and/or the chromatographic assay exhibits a harringtonines content higher than 97.5%.
Assignee: IVAX International GmbH
Inventors: Jean-Pierre Robin, Julie Blanchard, Jean-Pierre Marie, Nina Radosevic


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A History of Us
The Story of Science
DIY Lessons
Her Name was Judge: One of George Washington's slaves wanted to be free. Here is her story.
Ona Maria Judge was born at the most famous plantation in America, George Washington's Mount Vernon. It was about 1773. Judge's mother was black, enslaved, and a talented seamstress; her father was white and an indentured servant. When Ona (who was often called Oney) was 10 she was brought from the slave quarters to live in the mansion house, in part to be a playmate for Martha Washington's granddaughter. Eventually she became a private servant to the First Lady, which means she took care of her clothes, fixed her hair, and did personal tasks.
In the world of slavery, she had it easy. But Ona had a mind and she wanted more. She wanted to be able to read and learn. She wanted to go to a church she could choose. She wanted to be free.
The First President and his family moved to Philadelphia when that city was the nation's capital. (The District of Columbia wasn't ready.) Ona moved with them. That's where she was when Martha Washington told her she planned to give her granddaughter a very useful wedding present. Ona was to be that present. Can you imagine someone giving you away? In Oney's case it meant she would be leaving her friends and family.
Ona didn't want to be a wedding present (and she wasn't fond of the granddaughter). She had friends in Philadelphia, she went to them for help. They helped her make plans. So, while the Washingtons were having a fancy dinner, Ona Judge walked out the door and just kept going. She had saved money to pay for her escape, she had packed her things; she was soon on a ship, the Nancy, sailing north.
When the President and his wife discovered that Ona was gone, they were furious. They thought Ona was ungrateful and that they had treated her well. Washington, who had fought for freedom for his nation, didn't get it. He had cheered those words, "all men are created equal." But he didn't seem to think they meant women or anyone who was enslaved. To him slaves were property, which means they were worth money and had no right to their own selves. Actually he may have known better, but he was a victim of the ideas of his time and of the place where he lived. Most of his friends were doing it--keeping slaves--so he rationalized evil action. (Have you ever used the excuse: Well, everyone else does it.)
On May 24,1796 an advertisement appeared in The Philadelphia Gazette & Universal Daily Advertiser. It said:
Absconded from the household of the President of the United States, ONEY JUDGE, a light mulatto girl, much freckled, with very black eyes and bushy hair. She is of middle stature, slender, and delicately formed, about 20 years of age.
She has many changes of good clothes, of all sorts, but they are not sufficiently recollected to be described—As there was no suspicion of her going off, nor no provocation to do so, it is not easy to conjecture whither she has gone, or fully, what her design is; but as she may attempt to escape by water, all masters of vessels are cautioned against admitting her into them, although it is probable she will attempt to pass for a free woman, and has, it is said, wherewithal to pay her passage.
Ten dollars will be paid to any person who will bring her home, if taken in the city, or on board any vessel in the harbour;—and a reasonable additional sum if apprehended at, and brought from a greater distance, and in proportion to the distance.
The Nancy, piloted by Captain John Bowles, sailed to Portsmouth, New Hampshire. But even there, Ona Judge wasn't safe. She was walking down a street in Portsmouth when a friend of Martha Washington's granddaughter recognized her. It was the teenage daughter of Senator John Langdon.
George Washington soon learned of Judge's whereabouts. The President wrote to Oliver Wolcott, Jr., the Secretary of the Treasury, and asked that she be captured and returned.
Wolcott contacted Joseph Whipple, Portsmouth's collector of customs, and asked him to find Ona Judge. Whipple urged caution. He said that in New Hampshire news of an abduction could cause a riot by supporters of abolition. Whipple decided to talk to Ona Judge and see if she would return. She said she would if George and Martha Washington guaranteed that she would be freed when they died. "A thirst for compleat freedom…had been her only motive for absconding," Wolcott explained to the president.
Oney Judge runaway slave ad
Slaves in South Carolina circa 1862-1863
These lessons are intended for your use at home. They are copyrighted by Joy Hakim and are not for commercial use or redistribution.
There's more if you want to go farther with this story. The Fugitive Slave Act of 1793 had complicated things for runaway slaves and those who wished to help them. Something else: Oney Judge Staines was a "dower" slave. Legally that meant the Washingtons didn't own her directly. Martha Washington's estate owned the slaves who came with Martha from her first marriage. Oney was descended from one of them.
Further Reading: Check out this New York Times article on a recent book about Ona Judge and her story.
George Washington wouldn't agree to free Oney. The man who had fought for freedom for his nation couldn't understand that a black woman might also want to be free. He wrote to Whipple:
"I regret that the attempt you made to restore the Girl (Oney Judge as she called herself while with us, and who, without the least provocation absconded from her Mistress) should have been attended with so little Success. To enter into such a compromise with her, as she suggested to you, is totally inadmissible, for reasons that must strike at first view: for however well-disposed I might be to a gradual abolition, or even to an entire emancipation of that description of People (if the latter was in itself practicable at this moment) it would neither be politic or just to reward unfaithfulness with a premature preference [of freedom]; and thereby discontent beforehand the minds of all her fellow-servants who by their steady attachments are far more deserving than herself of favor."
Whew, faithfulness to him was more important that equality for her (or for others like her). So, Ona Judge stayed in New Hampshire: there she learned to read and was able to go to church. She became a devout Christian. She married Jack Staines, a sailor, and they had three children. Then Staines died and Ona was left to raise their family with almost no income. It wasn't easy. When asked if she was sorry she left the Washington's (where as a house servant she had privileges few enslaved people had), she said, "No, I am free, and have, I trust been made a child of God by the means."
In 1799 Washington wrote a new will saying that all his slaves were to be freed after he and his wife died. Then he directed that any very old or very young slaves were to be taken care of if they couldn't care for themselves in freedom. He said young slaves were to be taught to read and write and helped to find a "suitable occupation."
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Who Needs Courts When You Have President Obama?
Who Needs Courts Or Congress When You Have President Obama?
Liberals love America's checks and balances when the system works for them. But just let courts interfere, and they're immediately illegitimate.
Legal commentator Jeffery Toobin's recent piece in The New Yorker, "The Threat to Obama from the Courts," deserves nomination for Best Hack Performance in a Presidential Supporting Role. Toobin makes clear his take on the final years of this presidency: Obama's aims are laudable and good for the nation, while conservatives' aims are suspect and center mainly on tarnishing Obama's legacy and denying Mount Rushmore a chisel-ready project for January 2017.
In making his case, Toobin all but declares checks and balances on government power are not a crowning feature of America's constitutional formula, but cumbersome relics handed down by Founders who surely would have done better if they had foreseen a leader like Obama.
Before discussing the legacy-threatening courts, Toobin raises and dismisses Congress as a potential check on the president. He explains that fractious Republicans won't be able to pull together or overcome Democrat filibusters to pass significant legislation. Even if they could, Obama would veto anything he doesn't like. Therefore, Congress doesn't play large in this picture.
Toobin's prediction may prove accurate, but it's beside his point. Congress's inability to enact a conservative agenda is different from its ability—or lack of ability—to block Obama's liberal agenda. Toobin spends no time considering the tools Congress could, if so inclined, deploy to challenge the president: investigations, oversight hearings, budget restrictions on controversial initiatives, rejecting extreme nominees, and so forth. Dispirited conservatives might argue that Congress won't effectively check the president because Senate Majority Leader Mitch McConnell and House Speaker John Boehner seem not to have the stomach for a fight.
Congress's inability to enact a conservative agenda is different from its ability—or lack of ability—to block Obama's liberal agenda.
Toobin's tour makes port at Obamacare, immigration, net neutrality, and climate change. Throughout, he scrupulously avoide any fair or balanced description of the issues.
Toobin describes the plaintiffs' argument in King v. Burwell, an Obamacare case, as asserting that "four words in the text of the statute" mean that people in 34 states are ineligible for the Affordable Care Act's federal subsidies. He discernibly shouts, "That's ridiculous! What could be more trifling than four little words?" Presumably, Toobin would argue for executive flexibility in interpreting the difference between "the Secretary shall" and "the Secretary shall not" because after all, the difference is but a single word.
Presumably, Toobin would argue for executive flexibility in interpreting the difference between 'the Secretary shall' and 'the Secretary shall not' because after all, the difference is but a single word.
He renders the controversy over Obama's immigration orders thusly: "Early this year, President Obama used his executive authority to expand his program to allow certain undocumented immigrants who came to the country as children to remain here without the threat of deportation." Well. It's unfortunate 26 states are making a mountain of such a molehill. The president just "used his authority" to spare certain children deportation.
Somewhere in his editing and revising, Toobin must have removed an accurate description of major legal changes Obama's immigration actions have caused, changes that encompass 5 million immigrants: granting them work status, Social Security numbers, and welfare benefits. He also deleted mention of the 22 recorded statements where Obama admitted he doesn't have the authority to do what he just did. Toobin did see fit, however, to retain his description of the judge hearing the case, and the entire Fifth Circuit Court of Appeals, as "hostile" to Obama.
In the Toobin tour, net neutrality is a big win for consumers. Utility-style regulations will prevent big companies from jerking around viewers and content providers alike. It's not an audacious power grab, unauthorized by Congress, to control the Internet, which doesn't seem broken. There's apparently no good reason to oppose it. Still, Toobin sadly notes, a wave of legal challenges is surfacing even before the new regulations go into effect. What could be more mean-spirited?
Climate change is a fitting climax for Toobin's tour of the battle against Obama's legacy. "Industry representatives have brought multiple cases challenging virtually everything the Environmental Protection Agency has done to enforce the Clean Air Act." That's all our poor president is doing—enforcing the Clean Air Act!
The most perverse thing about Toobin's piece is the constitutional elephant in the room. Obama's unilateral agenda is enormously controversial.
Toobin assumes his audience is too dim know carbon is not a conventional pollutant. It doesn't make anyone cough or wheeze or get asthma. It is a plant nutrient that gives us a greener earth. It matters only if the alarmist version of global warming dogma is correct. The EPA's carbon rules will shut down domestic coal power, choke affordable energy, and harm millions of economically marginal Americans with much higher energy costs. Those aren't issues to consider, though. Only the spite of "industry representatives" for clean air merits notice.
The most perverse thing about Toobin's piece is the constitutional elephant in the room. Obama's unilateral agenda is enormously controversial. Public opinion tilts against most of it. Congress has not enacted it. Obama was just repudiated in historic midterm elections that gave Republicans their largest majorities in nearly a century. But to activist scribes like Toobin, it's as natural as the genetically unmodified seeds of heirloom tomatoes that a liberal president should steer the country wherever he wants.
It isn't remarkable that a rebuked, lame-duck president should launch initiatives to rewrite his healthcare law, transform immigration law, seize the Internet, and commandeer the U.S. energy sector without congressional agreement. No, what Toobin finds troubling is that judges might have the effrontery to stand in his way. After all, Obama has a transformative legacy to secure.
Shawn Mitchell served 14 years in the Colorado Legislature: three terms in the House and two in the Senate. He currently practices law in Colorado.


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Texas Chainsaw 3D (2013)
Movie Review by The Cenobite
I want to start off by saying I rented this movie and I did not watch it in 3d but I did see it in Blu-ray. None of that mattered or could save this movie. Now lets be real were not critics here were fans I like that, but man it was hard to sit through this movie as they butchered my baby to pieces. If you didn't catch this movie in theatre you might have missed it there was not much publicity or marketing around it, for petes sake in came out in January. All said and done this baby made 39 million worldwide respectable I guess. So the big question is why? Why make another Texas Chainsaw movie, there is a devoted cult following of the remakes and the originals so maybe they wanted to expand on that. Whatever the reason John Luessenhop took the challenge you may know him from his first directorial effort Takers. The script had so many rewrites it looks like a works cited page from a college thesis, another sign that maybe it should have been left alone. Lets get into the movie, it starts very intriguing with the ending of the first film finalizing what happened to the girl and the sawyer family. Finally tying into nowadays, I think. We have the heroine Heather miller who surprise, inherits a house from a grandma she never knew. The only thing to do is pack up your buddies and go on down to Texas too party at said house. Its no spoiler that Leatherface is in the house or that Heather is a part of the sawyer family. In fact its just plain boring. Many a horror movie has had bad acting that has helped the overall cheese or feel of the movie. Texas Chainsaw 3D falls short of that, its like teeters right on the edge but the acting comes off as just plain idiotic. We all wanna know about Leatherface right? How did they do Leatherface? This movie doesn't do a bad job as far as the looks he grunts, limps, his masks are nasty and perverted. There are a couples scenes where he is portrayed as a crazy simple madman much to my delight. If you have avoided spoilers thus far that's good, my problem is what they did with Leatherface and the heroine, its nonsense. For those who relish in all that is this film franchise Leatherface is a brother, I feel they lost him. Lost sight of what the family and franchise is about, all for cheap money and 3D razzle. Now that's not to say there isn't planty of gore, There is! Fingers, hands, feet, its all chopped off for the delight of gorehounds, but sadly its not enough. For me Texas fell flat and im hoping that they leave it in the ground forever, and let me remember the good times.
» Search Database for Texas Chainsaw 3D (2013)


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Worlds of Adventure
Worlds of Adventure is a weekly improv audio drama series from WLPP-LP 102.9 FM, Palenville NY, powered by DramaSystem. Host Susan Davis and a cast of four main characters create a world and a story each season, starting from a blank sheet of paper and a single sentence. The story might be science fiction, fantasy, horror, historical drama, or even Dogme 95-style literary fiction, but it will definitely be nothing like anything you can hear anywhere else. Nothing is scripted or canned; the story emerges on the fly as we record it
radio play
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Worlds of Adventure Season 1 Episodes
Beate Gördes Favorites
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wlpp-lp fm 102.9, palenville ny
Worlds of Adventure Episode 101A: "Hidden Truths, Part 1"
by WLPP-LP FM 102.9, Palenville NY
FBI agents Denver Winkle and Kate Wilma investigate the murder of a federal judge in the small Catskill mountain town of Lower Clove, New York. Denver clashes with county sheriff Bonnie Heinselmann. CC-BY-SA 4.0; see worldsofadventure.org/credits for full credits.
Topics: audio drama, radio drama, worlds of adventure, dramasystem
Worlds of Adventure Episode 101B: "Hidden Truths, Part 2"
The discovery of a second body complicates the FBI investigation into the murder in Lower Clove, New York. Kate is confronted with an unexplained phenomenon. Denver wants to get close to Bonnie's father, to learn the truth about his past. CC-BY-SA 4.0; see worldsofadventure.org/credits for full credits.
Topics: audio drama, radio drama, radio play, audio play, dramasystem, community radio, wlpp, worlds of...
Worlds of Adventure Episode 102A: "Loss, Part 1"
A trip up North-South Mountain to gather evidence in the murder of Aaron Benjamin goes horribly awry, landing Denver in the hospital, and leaving Kate missing. Bonnie encounters a face from her past. CC-BY-SA 4.0; see http://worldsofadventure.org for credits.
Topics: audio drama, radio drama, radio play, worlds of adventure, dramasystem, sf, science fiction,...
Worlds of Adventure Episode 102B: "Loss, Part 2"
Barney comes to town to search for Kate. Kate's fate is revealed. But who are her new friends? CC-BY-SA 4.0; see http://worldsofadventure.org/credits for full credits.
Topics: audio drama, radio drama, radio play, science fiction, fantasy, sf, sff, sci-fi, community radio,...
In 1987, 11-year-old Bonnie Heinselmann makes a new friend. In the present, a tongue-tied Kate is debriefed by her colleagues. CC-BY-SA 4.0; see worldsofadventure.org/credits.
Topics: audio drama, radio drama, radio play, worlds of adventure, community radio, wlpp
Worlds of Adventure Episode 109B: "Echo Chamber, Part 4"
The truth is revealed as Hank's memory returns. What will Bonnie, Denver, Kate, and Barney do with the information? CC-BY-SA 4.0; see http://worldsofadventure.org/credits for credits.
Topics: audio drama, radio drama, radio play, worlds of adventure, wlpp, community radio
Feb 5, 2016 02/16
In 1987, Bonnie makes and loses a friend, and Barney turns out to have been present when it happened. In the present day, is Kate losing her mind? CC-BY-SA 4.0; see http://worldsofadventure.org/credits for credits.
Topics: radio play, audio play, audio drama, worlds of adventure, community radio, wlpp
Worlds of Adventure Episode 104A: "Trouble in Paradise, Part 1"
Bonnie's father Hank receives a mysterious letter from Denver's parents. Denver gets the lab results he was waiting for. Barney reinstates Kate to duty. CC-BY-SA 4.0; see http://worldsofadventure.org/credits for credits.
Topics: radio drama, radio play, audio drama, community radio, wlpp, worlds of adventure
Worlds of Adventure Episode 104B: "Trouble in Paradise, Part 2"
Kate and Denver follow a mysterious stranger into an even bigger mystery. The FBI makes an arrest in the murder of federal judge Kenneth Laws. CC-BY-SA 4.0; see http://worldsofadventure.org/credits for credits.
Kate meets a strange man. Denver goes shopping. Bonnie reads Barney the riot act. CC-BY-SA 4.0; see http://worldsofadventure.org/credits for credits.
Topics: radio drama, radio play, audio drama, wlpp, community radio, worlds of adventure
Denver and Bonnie have words. Kate makes another friend. The investigation finds itself in the media spotlight, much to Barney's annoyance. CC-BY-SA 4.0; see http://worldsofadventure.org/credits for credits.
Worlds of Adventure Episode 106A: "Reckoning, Part 1"
In 1991, Denver's father warns Hank of upcoming trouble. In the present day, Barney helps Kate with her speech impediment, and cuts off Denver's purse strings. Kate seeks advice from Denise at the Pagan temple. CC-BY-SA 4.0; see http://worldsofadventure.org/credits for credits.
Topics: audio drama, radio drama, radio play, community radio, wlpp, worlds of adventure
Kate goes on a magical trance journey. Denver faces a disciplinary hearing for his actions in the investigation. Denise helps Hank with his memory problems. Barney calls in a favor from an old friend. Kate and Bonnie compare notes. CC-BY-SA 4.0; see http://worldsofadventure.org/credits for credits.
Worlds of Adventure Episode 108A: "Echo Chamber, Part 1"
In 1989, Denver's father saves Barney's life. In the present, Denver and Bonnie discuss family history. Kate and Barney find clues at Aaron Benjamin's house. CC-BY-SA 4.0; see http://worldsofadventure.org/credits for credits.
Worlds of Adventure Episode 107B: "Reckoning, Part 4"
Denver visits his childhood home. The FBI makes an arrest in a bioterrorism case. CC-BY-SA 4.0; see http://worldsofadventure.org/credits for credits.
Kate and Barney go to Woodstock. The FBI interrogates Syed al-Masri. Bonnie and Barney plan a trip to the mountaintop. Denise attempts to heal Hank. CC-BY-SA 4.0; see http://worldsofadventure.org/credits for credits.
Another teenager is missing in Hudson County. Denver holds a press conference about the investigation. Kate returns to duty. Bonnie seeks out Denise's advice. CC-BY-SA 4.0; see http://worldsofadventure.org/credits for credits.
Denver finds a clue at the scene of Judge Laws' murder. Barney and Denise have a heart-to-heart. Kate has words with Barney's boss. A mysterious scruffy man tries to warn Kate off the case. CC-BY-SA 4.0; see http:/worldsofadventure.org/credits for credits.
WorldsOfAdventure


Alexander Bockmayr : Eric Bourreau (Paris 13), Pierre-Etienne Moreau (Nancy).
Nicolas Hermann : Laurent Juban (Nancy).
Claude Kirchner : Christelle Scharff (Nancy), Ian Gamtini (Aix-Marseille).
Hélène Kirchner : Jean-Yves Vion-Dury (Grenoble), Pierre-Etienne Moreau (Nancy), Vincent Schachter (Paris-Sud Orsay).
Michael Rusinowitch : Mathieu Raffinot (Marne-la-Vallée), Nicolas Navet (Nancy), Philippe Balbiani (habilitation, Paris-Nord), Mohamed Tajine (habilitation, Strasbourg).


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Waiting for the U: The Bureaucracy of Obtaining Police Certifications for U-Visas
September 30, 2014 ·	by Samantha Howland ·	in Personal Stories, Politics & Policy	· Leave a comment
There is an art to navigating any government office or department. I would imagine this holds true in any country. That art is developed through careful research and creating social networks, so when the research is unavailable, you can always "ask around." In particular, this "asking around" is all too common when trying to navigate the immigration system in the U.S. This "asking around" can lead to a cumbersome process for even the simplest of tasks and can create delays and frustrations in developing an application for United States Citizenship and Immigration Services (USCIS) or Immigration Courts. While the Department of Homeland Security (DHS) and Department of Justice (DOJ) attempt to develop effective manuals and policies to better streamline procedures, they are not always internalized or successfully implemented by practitioners in the field.
USCIS offers a U-visa for victims of qualifying crimes in the U.S. who aid or are likely to aid in the investigation of the specific crime. Each year there are 10,000 visas available for victims of crimes. These visas serve as incentives for victims of crimes who do not have status to come forward without fear to the police and report crimes and work with both the police and prosecution to investigate and prosecute these crimes. In theory, offering victims a legal status in the U.S., helps keeps our cities and towns safer by reporting more crimes and having better police and judicial efforts for investigation and prosecution.
U-visas are incredibly important and a great resource for individuals without status in the U.S. and for police departments. In order to even apply for a U-visa an applicant must have a "certifying law enforcement agency" sign a certification that states that the victim was helpful, and is currently being helpful, or will likely be helpful in the investigation or prosecution of the case. Without this certification, an applicant is ineligible to apply for the U-visa. In order to help certifying agencies such as town and city police departments understand their role within this process, DHS has issued a U Visa Law Enforcement Certification Resource Guide to outline the process and provide a "how-to" for certifying agencies. Organizations and relevant actors are trained on what U-visas are and how they are awarded, but there seems to be a real lack of coherency in this understanding amongst these actors when it comes time to actually helping an individual obtain a "certifying agency signature." The following story best illustrates this incoherency, "asking around" and the extreme bureaucracy involved with obtaining this certification that may hinder many qualifying immigrants from obtaining this type of visa and continuing to aid in a police investigation.
There is clear room for a more streamlined process and trainings amongst law enforcement officials so that they know to suggest that a victim of a qualifying crime look into applying for a U-visa and that when it comes time for the certification that law enforcement knows exactly who the victims need to be referred to receive the certification.
John* was viciously assaulted and mugged in April of this year on his way home from work. The muggers attacked John with a bottle and broke his eye socket, broke his nose, and stole his wallet. They also attacked John's friend who was walking with him. A witness on the street immediately called the police and when the police arrived John and his friend told the police everything that happened and were transported to the hospital by ambulance. The police officers spoke with John in the hospital and even took photos of his injuries. John spent more than a week in the hospital recovering from 3 surgeries.
Once he was out of the hospital John followed-up with the police that were working on his case. John continued to call the police officer and went numerous times to the police station to see if they had caught his attackers and if they were going to be punished. Unfortunately, the police had not been able to identify his attackers. John was luckily able to recover from his injuries after about a month and a half, but still has a large scar on his face.
John heard from a co-worker, who had also been assaulted, about a U-visa and thought he might be eligible for one. John felt that he was a victim of an eligible crime of "felonious assault" and he had clearly met the definition of having "suffered substantial physical or mental abuse as a result of having been a victim of criminal activity." Additionally, John knew that he had been helping the police with details of the crime despite his fear of being undocumented.
John eventually decided he should apply for the U-visa and went and asked the officer he was working with about signing the police certification portion of the application. The police officer was sincere in his desire to help John, but he was unable to sign the application because he did not feel he was authorized to do so. The officer's supervisor was also hesitant to sign the certification and instead directed John to a totally different office with the hopes that "they handle these applications there." While the officer provided the name of the office, he was unable to provide a specific contact person. John went to this office and was told to go back to the police station and talk to the original officer who investigated his crime. After several trips back and forth, John finally decided to seek the help of a lawyer.
Due to a training on U-visas run by Catholic Charities, the lawyer knew exactly who the contact person for U-visa certifications was in John's city and initiated contact with this person immediately to begin the certification process. This particular office within the city police is highly knowledgeable about U-visas and police certification and John is in the process of obtaining certification.
While John's quest for police certification will hopefully be resolved soon, his story is by far too common Victims without legal knowledge or a knowledgeable social network may not even know that they are eligible for a U-visa and if their contact in the police department does not know who is the correct person sign the certifications, they may never overcome the initial hurdle of obtaining a police certification. Victims may become frustrated with the back and forth of different offices giving conflicting information. Other advocates for the U-visa claim that there are serious inconsistencies in how law enforcement agencies issue their certifications. It would be highly beneficial for police departments to become more knowledgeable about the availability and process of U-visas to better assist victims of crimes and encourage those without documentation to report crimes and actively participate in investigations and prosecutions. It would also be helpful for all town and city police departments to create a designated contact person for U-visas who is well versed in the process and can make accurate assessments of who is eligible for certification and be able to answer any questions victims may have.
The bureaucracy of this process is substantial, but with the right contact person or office, it can be streamlined and U-visas can provide lawful status to undocumented individuals who work with police and prosecutors to keep cities and towns safe in the U.S.
*John's name has been changed to protect his identity through his visa process and explicit permission was given to share his story on the condition of anonymity.
Tags: crimes, immigration, investigation, law enforcement, police, U visa, United States, victims, visas
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« Another week of national shame | Main | Mueller also had accountability, but evaded it »
Trump's pitiful walk-back
Trump soon realized that his foreign bashing of Biden — not to mention his customary cosseting of dictator Kim Jong-un — was a political blunder, born of reptilian spontaneity. But since an apology was out of the question for a self-proclaimed übermensch who can do no wrong, he had to come up with something — and this, pathetically, was it:
I was actually sticking up for Sleepy Joe Biden while on foreign soil. Kim Jong Un called him a "low IQ idiot," and many other things, whereas I related the quote of Chairman Kim as a much softer "low IQ individual." Who could possibly be upset with that?
North Korea's state-run media is more honest, in that unlike Trump, it's sticking by its original protest: "Biden has gone reckless and senseless, seized by ambition for power. [He had] reeled off rhetoric slandering the supreme leadership of the DPRK. What he uttered is just sophism of an imbecile bereft of elementary quality as a human being, let alone a politician." Concluded North Korea's commentary: "[Biden] is a fool of low IQ."
If only our "very smart" POTUS could be as pure of heart and consistently direct as Kim's editorialists.
And if only Trump's party and state-run media could be as honest and openly critical of the president as were two — count 'em, two — Republican congressmen. Adam Kinzinger of Illinois tweeted this to Trump: "It's Memorial Day Weekend and you're taking a shot at Biden while praising a dictator. This is just plain wrong." Added New York's occasionally independent Peter King: "Wrong for @POTUS Trump to criticize @JoeBiden in Japan and to agree with Kim Jong-un…. Never right to side with murderous dictator vs. fellow American."
As far as I know, the other 248 Republican congressfolk have been silent on Trump's utterly unAmerican partisan blather while in Japan.
Joe Biden's campaign, by the way, waited until Trump had returned to the White House before returning fire, which is the old-school, more genteel way of American politics. However with less gentility, his deputy campaign manager, Kate Bedingfield, said, among other things, that Trump's partisan comments while overseas were "part of a pattern of embracing autocrats at the expense of our institutions — whether taking Putin's word at face value in Helsinki or exchanging 'love letters' with Kim Jong Un."
True enough. Yet if Trump didn't embrace autocrats and take Putin's word at face value and exchange love letters with Kim, he'd have no foreign policy agenda at all.