No one is safe from cooking disasters, not even celebs. Neha Sharma speaks with some stars about their worst kitchen memories.
I have actually done a 3 year chef training program, and I've had many disasters. For my final exam, I had to prepare a German menu. My beef steak turned out like rubber and my apple strudel was like stone. The poor guy who had to evaluate it must have hated it. I passed somehow.
Once I baked a cake for my folks. The cake looked yummy until I cut it in front of them and saw the batter flowing out. Then I realised I had forgotten to add baking powder!
Gauri and I once tried making dal. We kept adding sugar thinking it was salt, because they look so similar. We couldn't understand why it wasn't becoming salty. When we figured it out, we added too much salt. Then we started adding sugar again. It didn't turn out as bad as it sounds, though.
Once I was making dal. I'd just turned to the refrigerator when there was a blast. The pressure cooker had burst and there was dal on the ceiling, walls, everywhere.
I was skewering kebabs on a barbeque grill at a friend's house in Cape Town and put lighter fuel on the meat instead of olive oil. The whole thing went up in flames!
I've never had major disasters except when I first made kaukswe for my husband's friends soon after I got married. I thought it would be a great alternative to the Hyderabadi cuisine they usually got. They thought it was a soup and wanted to skip it, thinking that the main course was waiting. I was horribly upset.


Results of active restoration in Chapada dos Veadeiros National Park, Goiás, Brazil (14°7'2.54″ S 47°38'30.36″ W). The area on the left side (A) was restored by direct seeding, leading to a vegetation structure more similar to a native Cerrado. Two native species can be seen in this area: Lepidaploa aurea, a short-lived shrub, and Aristida riparia, a perennial grass. The area on the right side (B) was not restored and is dominated by the invasive grass Urochloa decumbens. Photo credit: Alexandre Bonesso Sampaio.
Active restoration of savanna ecosystems is more recent compared with forest ecosystems, and, in many cases, it is still difficult to predict if an area under restoration will reach the desired conditions. The final community of species may depend upon several factors: the restoration method used, the abiotic conditions, how many and which species are introduced, and the presence of native and invasive species within or in the surrounding of the restoration area. In our study, we monitored the restoration of an area of Cerrado, the Brazilian savanna, by direct seeding, an active restoration method that has been applied recently for restoring grasslands and savannas. We observed the changes of the proportion of species during two years and verified that the community after this period is affected by the dominant functional group (the characteristics of the dominant species) at the beginning of the monitoring. Species that are short-lived but grows quickly and can cover the ground in a short time were important for the establishment of perennial grasses in the following two years, possibly because they prevented soil erosion and maintained good soil conditions. On the other hand, invasive grasses increased a lot in the restoration site, displacing native species in some localities within the area. This happened because the control of invasive species applied before seeding was not efficient enough to deplete the seed bank of invasive grasses, which were able to re-establish in the restored area.
Our results indicate the importance of introducing different functional groups when restoring severely degraded savannas, where the resprouting ability has been lost. A mixture of fast-growing/short-lived species with perennial species increases the chances of an establishment of native species through a fast species turnover. The inclusion of seeds of trees is also important to create the tree layer typical of savannas. We also recommend a strong control of invasive species, which can be done through the combination of different methods: usage of herbicides, prescribed fire, plowing the soil or topsoil removal. Considering these recommendations should increase the success of restoration strategies in severely degraded savannas.
This is a plain language summary for the paper of André G. Coutinho and colleagues, published in the Applied Vegetation Science.


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GPS 2022 Key Takeaways from Session One: Procurement Transformation In A Covid-19 World
by Admin | Apr 22, 2022 | Blog | 0 comments
Our first session of the excelerateds2p Global Procurement Summit 2022 focuses on procurement transformation in a Covid-19 world. Joining Joe Bellofiore, General Manager APAC at excelerateds2p on this panel discussion are special guests: Chirag Gidwani, Regional Sales Director at SAP and Richard Austin, General Manager at Mutual Marketplace.
The panel share their insights and experiences on implementing procurement transformation projects, both before, during and since the Covid-19 pandemic began. Chirag and Richard also discuss some of the common challenges and expand on ways of working, the impact of the pandemic on suppliers, and what some of their top priorities are for 2022.
We've rounded up the key takeaways from the session, however you can watch the full episode on demand here.
1. Use technology to stay agile
When the pandemic first hit, many organisations realised they did not have the agility they needed to quickly pivot their ways of working. Chirag explains "It created an initial crunch point on specific demand for IT equipment… everyone was working at home, but no one had printers or scanners, so documents could not get signed." He continues "e-signatures were somewhat off-limits at the time, so new legislation had to be brought in to allow for it".
The right technology and equipment will help your business stay agile and productive at short notice
2. Invest in Cloud-based technology
Cloud-based technology also plays a major role in tackling any short or long-term disruption. Richard discusses how Mutual Marketplace operates in "a fully cloud-based environment" that allows for expansion and growth as the business evolves. Chirag also adds that "cloud-based products have many advantages that early adopters have already benefitted from".
Early adoption of cloud-based technology gives you the tools to work and collaborate remotely and successfully navigate disruption
3. Leverage different technology platforms
Following the technology theme, Richard says that through technology "a lot of good change happened which was forced by the pandemic". One of the keys to this is being open to change and leveraging different platforms, including cloud-based. He continues, "By using the SAP platform we had implemented previously, it meant that when the pandemic hit, it did not change the way that we were interacting with our customers or the way we were communicating with suppliers".
Different technology platforms can give you the upper hand and help you move forward quickly and easily
4. Transformation through remote deployment
One of the keys to a successful procurement transformation process via remote deployment is engagement with both customers and internal stakeholders through every phase. Richard says that "our customers understood the insights, the benefit, and the value that it was going to add to them". Chirag agrees, adding "key stakeholder engagement is critical at this stage as it is one of the biggest hurdles to drive digital transformation in procurement".
Breaking down a remote transformation journey into smaller phases over time is easier than trying to complete the project in one go
5. Mitigate supply chain challenges
To mitigate the current global supply chain issues, Richard says businesses are becoming more proactive in their procurement, "They are recognising that, while they might not have a specific need now, they are anticipating a need in six to 12 months based on growth, so are ordering ahead of time". Chirag continues, "As a supplier, we can co-innovate a lot better when we have a strategic mutual understanding with our procurement counterparts. Supplier management is the most important part of procurement because it cuts across all the key objectives."
To mitigate supply chain challenges, work with your suppliers as a partner to plan and help mitigate risk
6. Use data to collaborate with suppliers
Joe looks deeper into the buyer/supplier relationship saying, "All the different elements [of supply chains] are underpinned by a fast, real-time sharing of data between buyers and suppliers". Chirag agrees, commenting, "businesses have real-time data to help make real-time choices and pivot extremely quickly", adding, "procurement teams need that data to deliver what the business needs".
Use data to make informed decisions on how to manage a supplier relationship and forecast demand to achieve supply chain continuity
7. Integrate your systems for the future
Once your transformation journey is complete, integration into any existing systems is crucial. As Chirag explains "Integration between other human experiences and ERP platforms is vital and having that integrated view of all your data, will help your organisation make decisions quicker and more confidently". As Richard says, "It is one thing to have a great tool that you can leverage, but unless you breathe life into it, it defeats the point."
Full integration between all your platforms will add value and enable your business to evolve
Watch this session on demand

redpajama_set_name: RedPajamaCommonCrawl


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Степа́нівка — село в Україні, в Кропивницькому районі Кіровоградської області. Населення становить 517 осіб. Орган місцевого самоврядування — Степанівська сільська рада.

Географія
У селі бере початок Балка Ляпколова.

Населення
Згідно з переписом УРСР 1989 року чисельність наявного населення села становила 533 особи, з яких 239 чоловіків та 294 жінки.

За переписом населення України 2001 року в селі мешкало 517 осіб.

Мова
Розподіл населення за рідною мовою за даними перепису 2001 року:

Примітки

Посилання
 Погода в селі Степанівка
 Про Степанівку на сайті Верховної ради України
 Степанівка на топографічних картах

Села Кіровоградської області

redpajama_set_name: RedPajamaWikipedia


Please don't wait. Find out how much a debt consolidation firm in Okeechobee, FL, could help you save.
There are around 3,320 people in Okeechobee who could use debt consolidation, and most of them would be best served by a debt management plan.
Debt management plans let you pay back your debts in full over time through one easy monthly payment. The advantages are significant: more affordable interest levels, monthly payments, and penalties. Most of the time your card issuers or lenders start providing these perks after three straight installments are submitted. If you're searching for a debt consolidation agency in Okeechobee, FL, this is one of the most inexpensive ways to go. Sign up should cost around $75, and monthly fees $25-40.
Many people try to pay down the money they owe with home equity loans, as there are tax advantages to doing so. Having said that, because this sort of loan is leveraged by your home, the bank or loan provider could get your home if you aren't able to make your payments. Wondering if a debt consolidation loan is best for you?
>> Find Okeechobee Debt Consolidation Solutions Now!
Payday loans have been gaining popularity because of the economic crisis. Close to 2,059 residents of Okeechobee get payday cash advances once or more a year, and roughly 906 of these borrowers are unable to repay their cash advances. This is quite a lot of borrowers who may be able to consolidate their Okeechobee payday loans!
Consolidate two or more payday advances.
Isn't it time to consolidate your Okeechobee payday loans?
If your debt load is over 50%, it is time to contact a debt consolidation expert in Okeechobee, FL.


Mick Jagger is many things. He's a legendary musician, great singer-songwriter, Rolling Stones rocker, ladies man. But did you know he's also a really dorky dad? That's right, the 74-year-old father of eight lets his geek flag fly on Instagram when commenting on his son's photos. He's got (dad) jokes!
There was the time Lucas went to Lollapalooza, something Mick found fun and funny.
Or when Lucas joked about hiding from the sun in a sunny photo, Mick found it amusing!
Mick is a fan of sunset photos — thank goodness since Instagram is filled with them.
The rocker also likes to use emojis every now and then because he's not a regular dad, he's a cool dad.
Mick Jagger… he's just like us.


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UIBM Report 2021: growing trend for patent applications in Italy
The higher number of filings of the last two years is also the result of the government incentives reserved for the innovative start-ups 4 March 2022
The Italian Patent and Trademark Office (UIBM) has recently released statistics about patent filings and grants in the year 2021. Patents for inventions reached the highest number ever of 11.031 patent applications filed. This number is just a little bit higher than the 10.977 patent applications for invention filed in 2020.
Thus, in the last two years, the number of patent applications filed was stable and pretty higher than the filings of the previous years, which in the last decade were always comprised between 9.000 and 10.000 filings.
In 2021, 7.248 patents for invention were granted by the office.
The higher number of filings of the last two years is also the result of the government incentives reserved for the innovative start-ups, which brought them to file almost 2.000 patent applications in 2020 and 2021, thus providing a huge contribution to the increase of filings in the last two-year period.
About the patents for utility model, 2.030 patents of this kind were filed last year. This number is in line with the average number of filings in the last five years, but less than the peak number of 2.389 patents for utility model that were filed in 2020.
The number of European patents validated in Italy dramatically drops in the last two years considering the 44.547 validations of 2019, then dropped to the 41.401 validations of 2020 and finally to the 36.192 validations of 2021.
Waiting for the release of the EPO statistics related to 2021, it should be noted that this trend reflects the decrease of EP patents granted by the EPO, that granted the highest number ever of 137.784 patents in 2019, then decreased to 133.709 patents granted in 2020. However, while the number of EP patents granted dropped about 3% from 2019 to 2020, in Italy the number of EP patents validated dropped about 7% in the same period, with a rate of decrease that is almost double than the continental one.


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Int. J. Morphol. vol.33 no.2 Temuco June 2015
http://dx.doi.org/10.4067/S0717-95022015000200044
Int. J. Morphol., 33(2):695-700, 2015.
Localization of Cannabinoid Receptor 1 (CB1) in Submandibular and Sublingual Salivary Glands of Mice throughout Postnatal Development
Localización de los Receptores Cannabinoides 1 (CB1) en Glándulas Salivales Submandibulares y Sublinguales de Ratones Durante el Desarrollo Postnatal
Wiphawi Hipkaeo*; Masahiko Watanabe** & Hisatake Kondo*,***
* Department of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
** Department of Anatomy, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
*** Histology Laboratory, Keiai-kai Medical Corporation, Maesawa, Japan.
SUMMARY: In view of the fact that human marijuana users often show dry mouth symptom, the present study was attempted to examine the localization of CB1, which was originally identified in brain, in the submandibular and sublingual salivary glands of postnatal developing male mice by immunohistochemistry. In submandibular gland, CB1-immunoreactivity was positive in a majority of acinar cells in forms of granular appearance in their apical cytoplasm, while it was negative in the ducts at newborn stage. The immunoreactivity decreased in the acinar cells at P1W and no immunoreactivity was detected in the acinar cells at P3W and thereafter. The immunoreactivity was positive in ductal cells at P3W and it remained positive thereafter until P8W stage. The immunoreaction was distinct on the apical plasmalemma of the intercalated ductal cells, while it was distinct on the basal plasmalemma of the granular convoluted ductal cells. The enhanced immunostaining on the lateral plasmalemma of the granular ductal cells was discerned only on P6W. In sublingual gland, CB1-immunoreactivity was detected in the demilune acinar cells and ductal cells only on P4W. Furthermore, CB1-immunoreactivity was shown to occur in the salivary ganglionic neurons, suggesting the CB1-inhibitory action in the saliva secretion through the parasympathetic nervous transmission.
KEY WORDS: Cannabinoid receptor 1; Immunohistochemistry; Submandibular gland; Sublingual gland; Postnatal mice.
RESUMEN: En vista de que los usuarios humanos de la marihuana a menudo presentan síntomas de sequedad oral, en el presente estudio se intentó examinar la localización de CB1, que se identificó originalmente en el cerebro, en las glándulas salivales submandibulares y sublinguales durante el desarrollo postnatal en ratones machos. En la glándula submandibular, la inmunoreactividad CB1 fue positiva en la mayoría de las células acinares de apariencia granular en su citoplasma apical, mientras que fue negativa en los conductos en la etapa de recién nacidos. La inmunorreactividad disminuyó en las células acinares en P1W y no se detectó inmunoreactividad en las células acinares en P3W. La inmunoreactividad fue positiva en las células ductales en P3W y se mantuvo positiva hasta la etapa P8W. La inmunorreacción se observó en el plasmalema apical de las células ductales intercaladas, mientras que fue distinta en el plasmalema basal de las células ductales contorneadas granulares. La inmunotinción mejorada en el plasmalema lateral de las células ductales granulares fue distingible sólo en P6W. En la glándula sublingual, se detectó inmunoreactividad CB1 en las células acinares y se observaron células ductales solamente en P4W. Además, se demostró que la inmunoreactividad CB1 se produce en las neuronas ganglionares salivales, lo que sugiere la acción CB1 inhibitoria en la secreción de saliva a través de la transmisión parasimpática nerviosa.
PALABRAS CLAVE: Receptores de cannabinoides 1; Inmunohistoquímica; Glándula submandibular; Glándula sublingual; Ratón postnatal.
Cannabinoids, natural components derived from the plant Cannabis sativa, have been known for many years as pharmacological properties, psychotropic drugs and medicinal agents with diverse systemic effects. The actions of cannabinoids in mammalian tissues have been clarified to be primarily mediated by two main types of cannabinoid receptor: CB1 and CB2 receptors whose cDNA cloning was already succeeded (Matsuda et al., 1990; Matsuda, 1997; Kano et al., 2009). The CBs belong to the G protein-coupled receptor superfamily. N-arachidonoylethanolamide (anandamide) and 2-arachidonoy- lglycerol (2-AG) have also been identified as endogeneous ligands, commonly termed endocannabinoids (eCB), for these receptors (Busch et al., 2004). CB1 receptors are expressed at high levels in the central and peripheral nervous systems, where their main role is to retrogradely modulate neurotransmitter release (Freund et al., 2003; Osborne et al., 2009; Navarrete & Araque, 2010). CB2 receptors are found in immune cells as well as within the cardiovascular gastrointestinal systems (Pertwee, 2001; Sanger, 2007; Wright et al., 2008).
The activation of CB receptors have been demonstrated to inhibit agonist-stimulated salivation and modify saliva contents, in accord with the known fact that marijuana users often decreases saliva secretions (Kopach et al., 2011). There have been several studies demonstrating that CB1 receptor is localized mainly in the ductal system, whereas CB2 receptor is in the acini in immunohistochemistry (Busch et al.; Prestifilippo et al., 2006; Dall'Aglio et al., 2010). Considering the fact that the development and differentiation of the duct-acinus system of the salivary gland progress at early postnatal stages of mice (Zajicek et al., 1985; Denny et al., 1990), and also that the salivary glands are under controlled by their specific parasympathetic nervous system, it is meaningful to examine the localization of CB1 in the parasympathetic ganglion as well as in the glands during the course of postnatal development of mice by immunohistochemistry, which was the main purpose of the present study.
Male albino mice of postnatal 1day (P1D), 1 week (P1W), P3W, P4W, P6W, P8W were perfused with 10 ml PBS, followed by 10 ml 4% paraformaldehyde/0.1 M phosphate buffer. The submandibular and sublingual glands were removed, then postfixed with the same fixative for 2 h. Specimens were dipped into 30% sucrose/0.1 M phosphate buffer for cryoprotection. Cryosections of 20 mm thickness were made and permeabilized with 0.1% TritonX-100/PBS for 20 min at room temperature, incubated with 0.3% H2O2/methanol for 10 min, then 5% normal goat serum/PBS for 30 min. Sections were incubated with mouse CB1 rabbit IgG (1 mg/ml) overnight at room temperature. The specificity of the antibodies was confirmed previously using CB1 gene knockout mice (Uchigashima et al., 2007). The sections were subsequently incubated for 1 h at room temperature with biotinylated anti-rabbit IgG secondary antibody (Vector Laboratories, Burlingame, CA USA) diluted at 1:250 for DAB reaction by VECTASTAIN Elite ABC kit (Vector Laboratories, Burlingame, CA USA). In control experiments, omission of the primary antibody was applied to sections. All procedures were conducted in accordance with Guidelines for the Care and Use of Laboratory Animals at Khon Kaen University. This study was approved by the Animal Ethics Committee of the Khon Kaen University, based on the Ethics of Animal Experimentation of the National Research Council of Thailand (Reference No.AEKKU 4/2014).
Submandibular gland. On postnatal 1 day (P1D), weak immunoreactivity for CB1 was detected in some acinar cells and the immunopositive materials were localized in the apical cytoplasm in forms of fine granules in the submandibular gland. No significant immunoreactivity was detected in the proximal or distal ductal cells throughout the gland (Fig. 1).
On postnatal 1 week (P1W), the weak and granular immunoreactivity in the acinar cells remained although the number of the immunopositive cells decreased. No immunoreactivity was seen in the ductal cells throughout the submandibular gland (data not shown).
Fig. 1. Acini of submandibular gland on postnatal 1 day of mice. Immunoreactive materials
in forms of fine granules are recognized in some acinar cells (arrowheads).
No immunoreactivity is seen in ductal cells (asterisks). Bar represents 20 µm.
On P3W, no immunoreactivity was detected in the acinar cells or ductal cells from the proximal to distal ducts (Fig. 2).
On P4W, while no immunoreactivity was maintained in the acinar cells, distinct immunoreactivity was seen in ductal cells throughout the intercalated, granular and striated portions of the distal ducts as well as the proximal excretory ducts (Fig. 3). In the intercalated portions, the immunoreactivity was distinct along the apical plasmalemma, although the entire cytoplasm was diffusely immunostained (Fig. 3a and 3b). In the granular portions, the immunoreactivity was confined to the basal cytoplasm with the basal plasmalemma distinct, while the lateral plasmalemma was much less distinct (Fig. 4).
Fig. 2. Submandibular gland on P3W of mice. No significant immunoreactivity
was discerned in acinar cells (arrowheads) or ductal cells (asterisks).
Bar represents 20 µm.
Fig. 3. Granular convoluted ducts (GC) of submandibular gland on P4W of mice.
Immunoreactive material was distributed diffusely in the cytoplasm with distinct deposits
along the basal plasmalemma. Note distinct immunoreaction along the apical plasmalemma
(arrowheads) of intercalated ducts enclosed by rectangles, whose higher magnification images
are shown in (a) and (b). A= acinar cell; ED= excretory duct; SD= striated duct. Bar represents 20 µm.
Fig. 4. Higher magnification immuno-light micrograph of granular convoluted ducts
shown in Fig. 3. Note distinct deposits of immunoreaction along the basal plasmalemma
(blank arrowheads), but no immunoreaction along the apical plasmalemma as well as
the apical cytoplasm occupied with secretory granules. Bar represents 20 µm.
On P6W, although the immunoreactivity pattern in the ductal cells was generally similar to the previous stage, the immunoreaction was distinct in the lateral as well as basal plasmalemma of the granular convoluted portions of distal excretory ducts, resulting in clear appearance of immunostained honeycomb patterns for the contours of individual ductal cells when the ducts were cut obliquely (Fig. 5)
Fig. 5. Granular convoluted ducts (*) of submandibular gland on P6W.
Note distinct immunoreactivity along the lateral plasmalemma of individual ductal cells
without significant immunostaining along the apical plasmalemma. Also note polyhedral
networks (thick arrow) of immunostained lateral plasmalemma in
tangentially cut granular ducts. Bar represents 20 µm.
On P8W, the immunoreactivity decreased in the ductal cells and it appeared diffuse with the basal cytoplasm slightly more distinct. However, the lateral plasmalemma was not distinct different from the previous stage (Fig. 6).
No distinct immunoreaction along the lateral plasmalemma of individual ductal
cells although the diffuse immunoreaction is still discerned in the cytoplasm.
Sublingual gland. Whereas no immunoreactivity was detected in any portions of the sublingual gland from P1D till P3W, the immunoreactivity was seen in almost all demilune acinar cells on P4W and the reaction materials were diffusely localized in the cytoplasm, but not in the nucleus (Fig. 7). The immunoreactivity was also seen in ductal cells of excretory ducts with the apical plasmalemma more distinct. On P6W, the immunoreactivity decreased remarkably and no immunopositive cells were detected throughout the gland on P8W.
Parasympathetic salivary ganglia. In addition to the glandular cells, moderate CB1-immunoreactivity was also detected in the submandibular and sublingual ganglia throughout the postnatal development till P8W (Fig. 8). The immunoreactivity was diffused in the cytoplasm of most individual ganglion cells. However, some of the cells were immunonegative. In contrast, no nerve fibers and terminals immunopositive for CB1 were detected to surround the glandular ducts or acini throughout the postnatal development.
In control experiments, omission of the primary antibodies alone resulted in the abolition of all immunostaining (not shown).
Fig. 7. Immunopositive reaction in demilune acinar cells (arrows) of sublingual gland
on P4W of mice. Distinct immunoreaction deposits are seen in the apical
plasmalemma of the intralobular ductal cells (*). Bar represents 20 µm.
Fig. 8. Immunopositive reaction in neurons of parasympathetic salivary ganglion
on P4W of mice. Arrow indicates immunonegative neuron. However, no nerve
fibers/terminals immunopositive for CB1 were found to surround the glandular
ducts and acini throughout the development. Bar represents 20 µm.
In accord with the previous finding in the submandibular gland of adult rats (Prestifilippo et al.), the present study confirmed dominant CB1-immunoreactivity confined to the ductal cells of the proximal and distal intralobular ducts of the submandibular gland in young adult mice on P4W~P8W. Although the site to produce eCB in the gland remains to be elucidated, it is likely that CB1 in the ductal cells causes qualitative and quantitative modifications of the saliva secretion at adult stages. In addition, the well-known fact that human users of marijuana cause a reduction in the amount of saliva is explained in such a way that the effect of exogenous ligands for cannabinoid receptor is mediated through CB1 in the ductal, but not acinar, system.
With regard to the subcellular localization in the ductal cells, the difference between the intercalated portion and granular convoluted portion should be noted: the distinct immunoreactivity in the apical plasmalemma of the intercalated ductal cells versus the basal plasmalemma of the granular ductal cells on P4W. In view of the distinct localization on the apical plasmalemma in the sublingual gland ducts, it is likely that the apical plasmalemmal localization is the prototype for the CB-inhibitory regulation in the ductal excretory function, and the basal plasmalemmal localization is special to the granular convoluted ductal portion which is dominantly involved in the secretion of granule contents. In addition, the transient enhanced appearance in the lateral plasmalemma of the granular ductal cells on P6W is also to be noted. It remains to be elucidated whether or not some enhanced inhibitory responses to eCB stimuli confined to this postnatal stage can occur in terms of the granule secretion in the ductal cells.
On the other hand, the present study disclosed for the first time the occurrence of CB1-immunoreactivity in the demilune acinar cells of the sublingual gland at young adult stages confined to P4W. Although the occurrence of CB-2-immunoreactivity was already reported in the demilune acinar cells of the submandibular gland of adult rats (Prestifilippo et al.), it is unlikely that the present finding is due to a possible cross-reactivity of the present antibody with CB2, because the specificity was already confirmed by employing CB1 gene knockout mice (Uchigashima et al.), and further because no immunoreactivity was detected with the present antibody in corresponding acinar cells in adult mouse submandibular cells. It is possible to consider that CB1 exerts some modifications on the saliva secretion in the sublingual acinar system as well as the excretory system in a way different from the submandibular gland, although confined to the limited young adult stages, at least in mice.
The present study also disclosed the occurrence of CB1-immunoreactivity in the salivary parasympathetic ganglion. Although the localization of CB1mRNA in the otic ganglion, which is another parasympathetic one, has been reported (Buckley et al., 1998), this is the first report demonstrating the occurrence of CB1-protein in the salivary parasympathetic ganglion. This finding suggests that CB1 is localized in the postganglionic neuronal terminals, in which the CB1 plays a regulatory role on the saliva secretion by inhibition of acetylcholine release, in addition to the role of CB1 in the ductal cells. However, no nerve fibers and terminals immunopositive for CB1 were discerned surrounding the glandular acini and ducts. There have been reports demonstrating clearly CB1-immunopositive nerve fibers/terminals in the central nervous system by immunohistochemistry using the same antibody as employed in the present study (Uchigashima et al.). It is possible that CB1 in peripheral parasympathetic nerve fibers/terminals is much lower than the immunohistochemical detection level unlike their neuronal somata, suggesting the main functional exertion at the soma. This possibility remains to be elucidated. With regard to the functional significance of CB1 in autonomic ganglia, the voltage-dependent modulation of natively expressed N-type Ca+2 (CaV2.2) channels has been shown following extracellular application of 2-AG in sympathetic neurons heterologously expressing CB1 receptor (Won et al., 2009). It is necessary to look for the origin of eCBs which could bind with the parasympathetic postganglionic CB1 in the salivary gland.
Finally, the occurrence of CB1-like immunoreactivity in forms of apical secretory granules in the submandibular acinar cells at newborn and P1W stages is briefly noted. The occurrence in forms of apical secretory granules is incompatible with this receptor nature belonging to the superfamily of G-protein-linked membrane receptors. It is crucial to examine first the authenticity of the immunoreactivity for CB1 for consideration of the functional significance of this peculiar localization of CB1-like immunoreactivity.
This work was supported by Invitation Research Grant, Faculty of Medicine, Khon Kaen University (No. I57202) to WH. We sincerely thank Mr. D. Hipkaeo for his technical support.
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Busch, L.; Sterin-Borda, L. & Borda, E. Expression and biological effects of CB1 cannabinoid receptor in rat parotid gland. Biochem. Pharmacol., 68(9):1767-74, 2004. [ Links ]
Dall'Aglio, C.; Mercati, F.; Pascucci, L.; Boiti, C.; Pedini, V. & Ceccarelli, P. Immunohistochemical localization of CB1 receptor in canine salivary glands. Vet. Res. Commun., 34 (Suppl. 1):S9-12, 2010. [ Links ]
Denny, P. C.; Chai, Y.; Pimprapaiporn, W. & Denny, P. A. Three-dimensional reconstruction of adult female mouse submandibular gland secretory structures. Anat. Rec., 226(4):489-500, 1990. [ Links ]
Freund, T. F.; Katona, I. & Piomelli, D. Role of endogenous cannabinoids in synaptic signaling. Physiol. Rev., 83(3):1017-66, 2003. [ Links ]
Kano, M.; Ohno-Shosaku, T.; Hashimotodani, Y.; Uchigashima, M. & Watanabe, M. Endocannabinoid-mediated control of synaptic transmission. Physiol. Rev., 89(1):309-80, 2009. [ Links ]
Kopach, O.; Vats, J.; Netsyk, O.; Voitenko, N.; Irving, A. & Fedirko, N. Cannabinoid receptors in submandibular acinar cells: functional coupling between saliva fluid and electrolytes secretion and Ca2+ signalling. J. Cell. Sci., 125 (Pt. 8):1884-95, 2011. [ Links ]
Matsuda, L. A. Molecular aspects of cannabinoid receptors. Crit. Rev. Neurobiol., 11(2-3):143-66, 1997. [ Links ]
Matsuda, L. A.; Lolait, S. J.; Brownstein, M. J.; Young, A. C. & Bonner, T. I. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature, 346(6284):561-4, 1990. [ Links ]
Navarrete, M. & Araque, A. Endocannabinoids potentiate synaptic transmission through stimulation of astrocytes. Neuron, 68(1):113-26, 2010. [ Links ]
Osborne, K. D.; Lee, W.; Malarkey, E. B.; Irving, A. J. & Parpura, V. Dynamic imaging of cannabinoid receptor 1 vesicular trafficking in cultured astrocytes. A. S. N. Neuro., 1(5):pii:AN20090040, 2009. [ Links ]
Pertwee, R. G. Cannabinoids and the gastrointestinal tract. Gut, 48(6):859-67, 2001. [ Links ]
Prestifilippo, J. P.; Fernández-Solari, J.; de la Cal, C.; Iribarne, M.; Suburo, A. M.; Rettori, V; McCann, S. M. & Elverdin, J. C. Inhibition of salivary secretion by activation of cannabinoid receptors. Exp. Biol. Med. (Maywood), 231(8):1421-9, 2006. [ Links ]
Sanger, G. J. Endocannabinoids and the gastrointestinal tract: what are the key questions? Br. J. Pharmacol., 152(5):663-70, 2007. [ Links ]
Uchigashima, M.; Narushima, M.; Fukaya, M. Katona, I.; Kano, M. & Watanabe, M. Subcellular arrangement of molecules for 2-arachidonoyl-glycerol-mediated retrograde signaling and its physiological contribution to synaptic modulation in the striatum. J. Neurosci., 27(14):3663-76, 2007. [ Links ]
Won, Y. J.; Puhl, H. L. 3rd. & Ikeda, S. R. Molecular reconstruction of mGluR5a-mediated endocannabinoid signaling cascade in single rat sympathetic neurons. J. Neurosci., 29(43):13603-12, 2009. [ Links ]
Wright, K. L.; Duncan, M. & Sharkey, K. A. Cannabinoid CB2 receptors in the gastrointestinal tract: a regulatory system in states of inflammation. Br. J. Pharmacol., 153(2):263-70, 2008. [ Links ]
Zajicek, G.; Yagil, C. & Michaeli, Y. The streaming submandibular gland. Anat. Rec., 213(2):150-8, 1985. [ Links ]
Wiphawi Hipkaeo
Khon Kaen University
Muang, Khon Kaen 40002
Email: wiphawi@kku.ac.th
hipkaeo1@hotmail.com
Received: 10-08-2014
Accepted: 04-03-2015


The political process generates substantive laws governing personal relations, crime, business, and other facets of life. Legislation is a primary vehicle for solving legal problems at a state, national, or international level.
Alternative dispute resolution is not applicable or available for Political Science Research.


Review: Why buy an HTC One M8 Google play Edition instead of a Nexus 5?
HTC's M8 Google Play edition is nice, but is it nice enough to justify the extra cost?
A controversial statement: I don't really care that much for the Nexus 5.
Oh, there's no denying it's a fine phone. It's fast, it gets updates quickly, it's solidly built, and its price is unmatched by any other smartphone vendor. These are the things that make the Nexus 5 (and the rest of the Nexus family) popular among the tech set. It's a really good deal.
And yet, it leaves me feeling a little cold. It's a very plain-looking slab, possessed of no particular style or distinctiveness. Its boxy edges feel awkward in the hand. It is exactly the sum of its parts: on paper it's superior to something like the Moto X in every possible way, but in practice I'd rather carry Motorola's phone than Google's.


Typically, to open a bank account one must go to the local office of their bank of choice, show their ID and spend a good portion of their time on the bank premises. This process, however, is changing as Estonia will soon allow both locals and e-residents to open a bank account via a video call.
Minister of Finance Sven Sester signed an order which will allow banks to open new accounts via video calls. This means that one will be able to open a bank account from a foreign country, or from their desk chair, without the need to ever visit the bank in person.
"Very soon, it will be possible to use a real-time video bridge for identification and verification of a person, which makes it possible to compare the image of a person's face with the data of their identification document and the data of the Police and Border Guard Board. The person will also be interviewed via the video bridge, which will help ascertain the client's risk profile i.e., assess their background, the origin of their financial resources and the purpose of establishing a business relationship. The entire process is recorded and the recording preserved," the Ministry of Finance says.
"Each credit-establishment is itself responsible for the security. The establishment needs to develop IT-systems, that cannot be manipulated by third parties. For privacy, there is a clause: as rule, only a potential client operates in the bank's systems and under their own name. The help of a third party is only possible with a special permit. If doubts arise, the interview may be cancelled and the client-relationship will not be forged," said the Minister of Finance.
"Banks will retain the right to identify a person by being at the same location as them. It will be up to the service provider to decide whether they want to open accounts for clients or conclude transactions using information technology tools. The service is meant for everyone who holds an Estonian ID card, digital ID or e-resident's card," he adds.
It should soon become much easier for both locals and holders of e-resident's cards to open a bank account in Estonia. However, it is clear that the main benefit is for foreigners, as opening a bank account was one of the last things a person physically needed to travel to Estonia for, in order to set up their business here.
The Minister of Finance explained, that enabling the opening of bank accounts via video-bridge will help to better serve the clients abroad who wish to use the services of Estonian financial institutions. He added that, if a foreign financial services provider would like to operate in the Estonian market and offer their clients the same options, it is possible as long as all of the regulations are met.
Kitter said that to begin with only locals will be able to open a bank account via video bridge but as time goes by, e-residents too can use the new option. "Once the service starts to work well, we can also offer it to e-residents," Kitter said.
The Ministry of Finance notes that earlier regulation required people taking part in a transaction, or using a service, to be identified by being present at the same location as the other party or their representative. If all conditions are met, identifying a person with IT tools will be equivalent to the identification of a person by being present at the same location. In the case of monitoring a business relationship, for example, the new and information technological solution is an even stronger measure than being at the same location as the other party or their representative.
"The know-your-client principle is applied differently in various European countries. There are countries, where you need to need present a bank with your utilities bill to prove your place of residence, and there are banks, which send a representative to visit their client at home before forging the client-relationship," the Minister of Finance said.
"There are also clients who do not wish to abandon the traditional visiting of bank offices," he added.
"The Estonian society is technology-friendly and as such, banks need to move to channels that their clients prefer. The private sector is observing and carrying the technological development, so it can be assumed, that different solutions for offering financial-services will emerge in Estonia and elsewhere. We are ready to share our experiences and are interested in the steps others are taking as well," he said.
E-resident? Doing business? Access business banking without leaving your desk!
Estonia's e-Residency programme, which enables anyone in the world to become a digital resident of the country, has exciting news.
According to Funderbeam Start up Investment Report, Estonia is third in Europe regarding the highest number of startups per capita.


text:
export const getScopeId = (vm, defaultValue = null) => {
  return vm ? vm.$options._scopeId || defaultValue : defaultValue
}

redpajama_set_name: RedPajamaGithub


Sorry! Been real busy lately and thus the lack of updates. Been doing lots of bridal nails, and of cos some festive sets and lastly my regular customers. For now, 3 sets of nail pics!
This is a set of bridal nails I did. Bride saw some of the frilly nails I did and said she'd love to have that and ribbons on her nails. And there, this design is created.
This is done on acrylic extension. Lovely frills with pink AB and clear crystals. Pink AB crystals are so sweet and sparkly in real life.
This is done on one of my regular customer. Initially she chose one of the design from Nail Max, then saw another, then combined all she likes into a set of nails. Pink, glittery, hearts, roses and ribbons. All in one set! :) This is done in acrylic as well.
Her thumbs. Overloaded. But we love it! Love the pink stripey hearts!
Ok, a set of sweet and simple gel extension.
Light pink glitter tips, round pink disco ball (remember the Disco Ball nails I did?) flakes, and some holo flakes embedded. Actually, the pink disco ball flakes look very glossy and pinkish at different angles. It's really bad that pics don't show.
Will post more next week. Night night!
i really love your blog, awesome nails!


text:
Helvete (Swedish for "hell") is an album by Swedish grindcore band Nasum, released in 2003.

Mitch Harris (Napalm Death) made a live music video for the song "Scoop". This video can be found on Nasum's website. Shane Embury from Napalm Death plays bass guitar on "Drop Dead" and "Whip".

In February 2009, Helvete was ranked number 2 in Terrorizers list of essential European grindcore albums, with writer Olivier 'Zoltar' Badin describing it as "confirming Nasum as the undisputed kings of the new wave of Swedish grindcore".

Track listing

References

Nasum albums
Relapse Records albums
2003 albums


While there's no topping the fun of marathoning through Halloween movies, paging through scary reads and knocking items off a bucket list of fall fun, sometimes the best activities are the ones that show off how cool nature can be. No, we're not talking hikes, though those are pretty fun too. Today we're tackling meteor showers, an easy fall activity that calls for little more than laying on a blanket or curling up in a lawn chair and gazing into space. Get to know your constellations and mark your calendars — we've got six reasons to lay under the stars with your eyes on the skies.
For extra credit, check out the Ursids in late December. This shower starts up right after the Geminids on December 17 and runs until December 23, peaking just before the winter solstice. On December 21, don't turn on the tree or light the candles in the windows — just head outside and look up. This shower will bring you plenty of twinkling lights.
Which meteor shower will you catch? Let us know in the comments below!


Our Lexington nursery boasts a fresh, urban vibe. Deeply rooted as a wholesale nursery for 20 years, we once catered exclusively to the professionals who shaped Central Kentucky landscapes. Now, we've blended the rugged aesthetic of a wholesale nursery with a classic and artful eye for detail as well as the exceptional plants for which Wilson's is known. Now, our welcome is extended for ALL to experience a new place for plants in Lexington.
Have a question about our Lexington location? Feel free to drop us a line.


We only accept applications when we have open positions. Please check with Laura Marvel to determine if we have open positions.
Click on the link above to open the application in Word.
Fax the completed/signed application to 702-395-0858.


text:
Vicente Fernandez Net Worth, Age, Height, Relationship Status
March 21, 2022 by methew hide
Vicente Fernández Gómez is a retired Mexican singer, actor and film producer. He is considered a cultural icon of Mexico for his work, which includes the creation of more than 50 albums and participation in more than 30 films. As of 2021, Vicente Fernandez's net worth is estimated to be around $25 million.
During his stellar career, Vicente was nicknamed El Ídolo de México, which translates to "The Idol of Mexico." Vicente has won three Grammy Awards and a total of eight Latin Grammy Awards during his career.
Full Name Vicente Fernández Gómez
Birth Date 7 February 1940
Birth Place Guadalajara, Jalisco, Mexico
Profession Retired Singer, Actor, and Film Producer
Net Worth $25 million
Vicente was born in a place called Guadalajara, Jalisco, Mexico. Vicente started playing the guitar when he was only eight years old and was influenced by the films of Pedro Infante, which planted the seeds of music in his mind.
As a child he participated in various festivals and sang, in particular, participating in various competitions. In an interview, he recalled winning 31 pesos at the age of 12 in a contest that gave him confidence in his musical abilities. This prompted him to play for various local clubs and rallies.
His father owned a ranch where Vicente spent most of his childhood. But unfortunately, his father lost the ranch and Vicente dropped out of school when he was only in fifth grade.
Vicente Fernandez Net Worth and Career
Fernández began his career working as a janitor, dishwasher and waiter to make ends meet. However, he pursued his musical ambitions, whatever his life situation might be.
In 1960 Vicente decides to dedicate himself entirely to music. He performed as a busker and also appeared in the musical Kalandria. Thanks to his perseverance, in 1966 he managed to get a contract with CBS Records International in Mexico.
Vicente was involved in a long-term partnership until his retirement with the same label, now called Sony Music Latin.
He also began to make waves over the years with one of his first hits, La ley del monte, released in 1974.
In 1963 Vicente married María del Refugio "Cooka" Abarca Villaseñor. With María, the couple had three sons named Vicente Jr., Gerardo and Alejandro. Regarding political affiliation, Vicente was affiliated with the Institutional Revolutionary Party (PRI) from 1929 to 2000 and again from 2012 to 2018.
Vicente has been the subject of several controversies, but more recently his hand was seen on a fan's chest in a photo that sparked outrage on social media. Vicente later apologized for the incident.
Vicente Fernandez net worth
As of 2021, Vicente Fernandez's net worth is estimated at $25 million. Vicente managed to solidify his place among the best singers in Mexico and became a legend. Vicente has given several concerts that have filled countless stadiums for more than 40 years and over time he has been able to amass a great fortune thanks to his work and dedication.
Alex Zedra Net Worth, Age, Height, Relationship Status
Beyonce Bio Height Weight Net Worth, Age, Height, Relationship Status


text:
1 John 2:6
6 Those who say they live in God should live their lives as Jesus did.
1 John 2:6 — The New International Version (NIV)
6 Whoever claims to live in him must live as Jesus did.
1 John 2:6 — English Standard Version (ESV)
6 whoever says he abides in him ought to walk in the same way in which he walked.
1 John 2:6 — King James Version (KJV 1900)
1 John 2:6 — The New King James Version (NKJV)
6 He who says he abides in Him ought himself also to walk just as He walked.
1 John 2:6 — New Century Version (NCV)
6 Whoever says that he lives in God must live as Jesus lived.
1 John 2:6 — American Standard Version (ASV 1901)
6 he that saith he abideth in him ought himself also to walk even as he walked.
1 John 2:6 — 1890 Darby Bible (DARBY)
6 He that says he abides in him ought, even as he walked, himself also so to walk.
1 John 2:6 — GOD'S WORD Translation (GW)
6 Those who say that they live in him must live the same way he lived.
1 John 2:6 — The Holman Christian Standard Bible (HCSB)
6 The one who says he remains in Him should walk just as He walked.
1 John 2:6 — The New Revised Standard Version (NRSV)
6 whoever says, "I abide in him," ought to walk just as he walked.
1 John 2:6 — The Lexham English Bible (LEB)
6 The one who says that he resides in him ought also to walk just as that one walked.
1 John 2:6 — New International Reader's Version (NIrV)
6 Those who claim to belong to him must live just as Jesus did.
1 John 2:6 — New American Standard Bible: 1995 Update (NASB95)
6 the one who says he abides in Him ought himself to walk in the same manner as He walked.


text:
Fiscal Year 2014 State Department Budget Request
2013-04-17T23:11:50-04:00https://images.c-span.org/Files/aa3/20130417104922001_hd.jpgSecretary of State John Kerry testified before the House Foreign Affairs Committee about the State Department's fiscal year 2014 budget. He said the window for a two-state solution in the Middle East is shutting. He also provided an update on the State Department's investigation into the Benghazi attacks and discussed U.S. efforts to denuclearize North Korea. This was John Kerry's first appearance on Capitol Hill since becoming Secretary of State in February 2013.
Secretary of State John Kerry testified before the House Foreign Affairs Committee about the State Department's fiscal year 2014 budget. He said the… read more
Secretary of State John Kerry testified before the House Foreign Affairs Committee about the State Department's fiscal year 2014 budget. He said the window for a two-state solution in the Middle East is shutting. He also provided an update on the State Department's investigation into the Benghazi attacks and discussed U.S. efforts to denuclearize North Korea. This was John Kerry's first appearance on Capitol Hill since becoming Secretary of State in February 2013. close
Transcript type Closed Captioning Record People Graphical Timeline
Filter by Speaker All Speakers Karen Bass Ami Bera M.D. Mo Brooks Steven Chabot David N. Cicilline Doug Collins Gerry Connolly Tom Cotton Ted Deutch Eliot Engel Lois J. Frankel Tulsi Gabbard Alan M. Grayson Brian Higgins Bill Keating John F. Kerry Adam Kinzinger Michael McCaul Mark Meadows Gregory Meeks Ted Poe Dana Rohrabacher Ileana Ros-Lehtinen Ed Royce Matt Salmon Brad Schneider Brad Sherman Albio Sires Chris Smith Randy Weber Joe Wilson
Karen Bass U.S. Representative [D] California
Ami Bera M.D. U.S. Representative [D] California
Mo Brooks U.S. Representative [R] Alabama
Doug Collins U.S. Representative [R] Georgia
Tom Cotton U.S. Representative [R] Arkansas
Ted Deutch U.S. Representative [D] Florida
Eliot Engel U.S. Representative [D] New York
Lois J. Frankel U.S. Representative [D] Florida
Tulsi Gabbard U.S. Representative [D] Hawaii
Alan M. Grayson U.S. Representative [D] Florida
John F. Kerry Secretary Department of State
Michael McCaul U.S. Representative [R] Texas
Mark Meadows U.S. Representative [R] North Carolina
Gregory Meeks U.S. Representative [D] New York
Ted Poe U.S. Representative [R] Texas
Ileana Ros-Lehtinen U.S. Representative [R] Florida
Ed Royce U.S. Representative [R] California
Matt Salmon U.S. Representative [R] Arizona
Brad Schneider U.S. Representative [D] Illinois
Brad Sherman U.S. Representative [D] California
Albio Sires U.S. Representative [D] New Jersey
Chris Smith U.S. Representative [R] New Jersey
Randy Weber U.S. Representative [R] Texas
House Foreign Affairs CommitteeHouse Foreign Affairs Committee
House Committee
Apr 17, 2013 | 9:30am EDT | C-SPAN.org
Apr 23, 2013 | 5:11am EDT | C-SPAN 2
Apr 17, 2013 | 10:39am EDT | C-SPAN 1
Apr 17, 2013 | 3:24pm EDT | C-SPAN 3
Apr 17, 2013 | 11:11pm EDT | C-SPAN 1
See all on Department of State Benghazi
Benghazi Consulate Attack
Patrick Kennedy testified on State Department internal actions to address its responsibility for the terrorist attack on the U.S. Consulate in…
State Department Fiscal Year 2015 Budget Request
Secretary of State John Kerry appeared before the House Foreign Affairs Committee to discuss the fiscal year 2015…
House Session, Part 1
The House debated a closed rule for H.Res. 567, establishing a select committee to investigate the Sept. 11, 2012…
Secretary of State John Kerry testifed before the House Foreign Affairs Committee on his department's the fiscal year…
Secretary Kerry Defining Backyard Diplomacy
Rep. Tulsi Gabbard questioning Secretary Kerry about North Korea


text:
Q: Print multiple characters, formatted as an integer Whenever I run this program, It gives output 12592.
I couldn't find the logic behind it. It it in C Programming.
#include <stdio.h>

int main()
{

    printf("%d",'10');

    return 0;
}

A: '10' is actually a multi-character constant.
It has a type int, just like say '1', but its actual value is implementation defined.
Quite feasibly its value is '1' * 256 + '0' which is 12592 on your platform which is, from what I can tell, using ASCII encoding.

A: As everyone else has said, you are using a multi-character constant, and their explanations tell you WHY you get the result you get, as asked.
If you intended to print out the integer literal value 10 (so far not commented about directly), use
printf("%d",10);

Note there are no single quotes on the second parameter.
For that matter,
printf("10");

OR
printf("%s","10");

(print the string literal) would do just as well.

A: In C (and C++), the apostrophe character ' is used to form a character constant.  Normally, what goes between the apostrophes is one single character like 'A', or an escape sequence representing one single character, like '\n' or '\001' or '\x01'.
For historical reasons, it's permissible to put multiple actual characters between the apostrophes, as in 'AB', or the case you asked about, '10'.  These are called multi-character character constants.
This is a questionable thing to do.  The result is implementation defined, meaning it may do different things under different compilers (although the documentation should tell you what it does).  It may also be quite different between C and C++.
Since it's not well-defined what it does, and since there are few good uses for it even if it were well-defined, the usual advice is to just not use multi-character character constants.  (And if you don't use them, you don't even have to know what they do.)
Under most C compilers, what you get when you do this is the result of "appending" the two characters in memory -- that is, creating a 16-bit number by putting two 8-bit numbers next to each other. (For now I'm assuming just two characters in the multi-character character constant, although actually there might be even more).  It may be easiest to explain this with an example:
#include <stdio.h>

int main()
{
    printf("%d (%02x) %d (%02x) -> %d (%02x)\n", 'A', 'A', 'B', 'B', 'AB', 'AB');
    printf("%d (%02x) %d (%02x) -> %d (%02x)\n", '1', '1', '0', '0', '10', '10');
}

On my machine this prints
65 (41) 66 (42) -> 16706 (4142)
49 (31) 48 (30) -> 12592 (3130)

(But, side note, on my machine my compiler gives me the message "warning: multi-character character constant", reinforcing the notion that multi-character character constants are usually a bad idea.)
Looking at the second example as bytes in memory; '1' looks like
+------+            +----------+
| 0x31 |     or    | 00110001 |
+------+            +----------+
And '10' looks like
+------+------+            +----------+----------+
| 0x31 | 0x30 |     or    | 00110001 | 00110000 |
+------+------+            +----------+----------+
Where does that number 12592 come from?  It's the decimal representation of the hexadecimal number 0x3130.  Or, stated another way, it's 256 × 49 + 48.

redpajama_set_name: RedPajamaStackExchange


text:
November 19, 2014 2:11PM ET
Official Bob Marley Marijuana Blend On the Way
Marley Natural blend will hit states where weed is legal next year
Bob Marley in concert in Atlanta on November 12th, 1979.
Tom Hill/Getty
The world's most famous reggae singer is on the verge of becoming the Marlboro Man of Marijuana: The Bob Marley estate has licensed the Legend singer's name and likeness to create a special blend of herb dubbed Marley Natural.
Marley's widow Rita Marley and children Cedella and Rohan have teamed up with Privateer Holdings, a private equity group specializing in the legal marijuana market, to exclusively mass-produce those "heirloom Jamaican cannabis strains" that Marley himself smoked to make the Rock and Roll Hall of Famer the face of the herb revolution. Privateer also owns Tilray, a 60,000-square-foot property on Vancouver Island, British Columbia that ranks as the world's largest marijuana grow farm.
A Bright Green Spot in a Dark Election: Weed Is More Legal Now
50 Best Action Movies of All Time
Although the blend won't hit the States where pot is legal – which now includes Alaska and Oregon – until late-2015, Marley is now positioned to become the face of a movement to legalize weed not just in America but worldwide. "Bob Marley started to push for legalization more than 50 years ago. We're going to help him finish it," Privateer Holdings CEO Brendan Kennedy told NBC News.
"It just seems natural that Daddy should be part of this conversation," Cedella Marley, 47, the reggae legend's first-born daughter, told NBC News in a taped statement. "As Daddy would say, 'make way for the positive day.'" Son Rohan Marley added, "Herb is for the healing of the nation; herb is for the meditation; herb is for the higher vibrations."
Rita Marley, who was once a member of Marley's backup singing group the I Threes, said in a statement, "You can depend on Bob, too. He's 100 percent behind what is happening. He's happy because this is what we dreamed of," referring to marijuana legalization. "It was unruly for them to call it weed or drugs. We saw it as a spiritual thing, given to us by God." The Marley family also shared a commercial for the Marley Natural, as well as the blend's logo, a dread lion positioned between two pot leaves.
Marley finished ninth on Forbes' most recent list of the top-earning dead celebrities, with annual earnings of around $20 million for his estate (not including all the bootlegged clothing and paraphernalia featuring the singer's likeness). With the release of Marley Natural Fine Cannabis, and with the legal weed industry in America already at $50 billion and climbing with every state that decriminalizes marijuana, Marley's estate can expect to rocket up the posthumous earnings list in the near future.
Check out the NBC News report on Marley Natural:
In This Article: Bob Marley


Queen of Puddings is a traditional British pudding that brings together a thick breadcrumb custard, raspberry jam and a fluffy crown of meringue.
This easy Queen of Puddings recipe is a simple way to make the traditional British pudding. Layers of thick breadcrumb custard, raspberry jam and pillowy meringue all come together in a delicious dessert.
This is a wonderful comfort dessert that's enjoying a resurgence in popularity. Rightly so! The thickened custard is a great base and the breadcrumbs turn the custard into an almost cake-like texture, with the jam adding a sweet sharpness. The meringue is a crowning glory on this most regal of desserts. I've teamed up a2 Milk™ to bring you this recipe and I hope you enjoy it!
What is Queen of Puddings?
You may have heard of this traditional dessert on Bake Off or perhaps you've had it before. It's an old fashioned British pudding – and it's experiencing a bit of a revival! Queen of Puddings is easy to make and it brings together some of the best components of puds – custard, jam and fluffy baked meringue.
Legend (ie the internet) has it that Queen Victoria was visiting Manchester, tasted a similar breadcrumb custard and meringue pudding and loved it so much that they named it after her.
There are many breadcrumb desserts, from bread pudding to Christmas pudding. They're a great way to use up stale bread and I often try to reduce food waste by blitzing bread ends and saving them in the freezer.
This is a simple and straightforward dessert to make, but it tastes very special indeed.
Just follow the below steps to make this regal Queen of Puddings!
How to Make Queen of Puddings. Step 1: Heat the milk, add breadcrumbs, vanilla and lemon zest. Allow to sit for 10 minutes, then beat in the egg yolks and pour into the baking dish.
How to Make Queen of Puddings. Step 2: Bake for 30 minutes or until the custard is set but still a bit wobbly.
How to Make Queen of Puddings. Step 3: Melt the jam in a saucepan slightly, allow to cool a bit and then spread over the baked custard.
How to Make Queen of Puddings. Step 4: Beat the egg whites and remaining sugar until stiff and glossy. Spoon onto the jam, right to the edges, and use the back of a spoon to create swirls and peaks. Sprinkle with the remaining 1 tsp of sugar. Bake until golden.
If you make this Queen of Puddings recipe, please tag it with #veggiedesserts on Instagram or other social media. I LOVE seeing your recreations of my recipes!
This Queen of Puddings is easy to make and a fantastic traditional British dessert. It has a base of baked breadcrumb custard topped with raspberry jam and a crown of fluffy meringue.
Preheat the oven to 160C. Generously butter a 1.5 litre/9" pie dish.
Bring the milk in a saucepan just about to the boil. Remove the pan from the heat, then mix in the breadcrumbs, half of the sugar, butter, lemon zest and vanilla, stirring until the sugar is dissolved.
Leave for approximately 10 minutes to cool and for the breadcrumbs to thicken the custard. Beat in the egg yolks (save the whites for the meringue), then pour the mixture into the prepared pie dish.
Bake for 30 minutes until the custard is set, but still wobbles slightly. Leave the oven on.
Meanwhile, melt the jam in a small saucepan, then set aside to cool slightly.
For the meringue, use an electric whisk to beat the egg whites until stiff peaks form, adding the remaining sugar slowly a teaspoon at a time to form a thick and glossy meringue.
Spread the jam over the custard evenly.
Starting at the outer edge, spoon the meringue in large heaps over the jam, ensuring that it reaches the edge and is fully covered. With the back of a spoon, delicately tap the meringue to form decorative peaks. (Optionally, you can use a piping bag to pipe the meringue onto the dish). Sprinkle the top with the remaining teaspoon of sugar.
Return the dish to the oven and cook for 10-15 minutes or until the meringue is golden. Enjoy warm or at room temperature.
To make this gluten-free, just substitute gluten free breadcrumbs.
I've been working with a2 Milk™ over the past year to bring you recipes using their fresh cows' milk that's naturally easy to digest.
Many people with issues digesting milk may not need to live lactose free. The solution to their symptoms could be as simple as choosing a milk that is naturally free from the A1 protein, such as a2 Milk™ which has no compromise on taste or nutrition.
New research was published in November which suggests that the true cause of the symptoms of lactose intolerance for many people could in fact be the A1 protein found in most regular cows' milk. The clinical trial, conducted in China and involving 600 adult Han Chinese participants with self-reported lactose intolerance, has reported that consumption of a2 Milk™ containing only A2 beta casein reduced acute gastrointestinal symptoms compared to consuming conventional milk containing A1 and A2 beta casein proteins. The study authors say that their findings demonstrate that, in some individuals with self-reported lactose intolerance, the adverse gastrointestinal symptoms following consumption of regular milk may be related to the presence of A1 beta casein protein rather than lactose itself. You can read more about the study on a2 Milk™.
a2 Milk™ is not suitable for cows' milk protein allergy. If you have been medically diagnosed with any milk intolerance, seek advice from your doctor before use.
Disclosure: This Easy Queen of Puddings recipe was commissioned by a2 Milk™. All opinions are my own. Thanks for supporting the brands that make it possible for me to be a UK food blogger and write Veggie Desserts.
I didn't have any raspberry jam, but made it with strawberry and it was yum! Made it for my grandmother's birthday because it's her favourite pudding.
Oh this looks so good, that meringue looks amazing. I can't wait to try this out. Thanks so much for sharing.
I'm bookmarking this for later, looks so easy to make and so tasty!
This looks so easy and sounds delicious!
I would be very interested in trying this. That meringue and raspberry jam oozing out of there looks so delicious!
I've never tasted a pudding like this but it looks really good! Perfect for a fancy dinner party!
This pudding looks delicious and I love the step by step directions!
What a delicious looking dessert. I love the meringue topping.
This looks delicious! I\m always looking for good new pudding recipes to try.
I could eat the whole thing – right now!!
This looks delicious! And it's good to know there's alternatives to soya milk for people with lactose intolerance!
I've not heard of Queen of Pudding before but it looks amazing. I love meringue so will have to try this myself.
This looks so so good. I have also loved meringue puddings too. Thanks for sharing.
I love Queen of Puddings! Anything with meringue in it gets my vote.
This looks delicious! It also seems super easy to make too as there are only 6 ingredients that are all easy to get hold of! I can't wait to try this recipe out, thank you so much for sharing!
This would be my daughter's ideal Pudding. I might have to treat her and make it over Christmas.
I hope you get the chance to make it for her!


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An Entertaining Ride With Not Enough Horsepower
It was the dream vehicle of every kid living in the '70s. It's the car that goes hand in hand with Back to the Future. Yep, we're talking about the DeLorean. Everyone knows something about the famous car but what do you know about its creator John DeLorean?
Whether it's nothing or a lot, you will certainly know more about him after watching "Driven". This latest work from director Nick Hamm sputters ("The Journey", "Killing Bono") at some times but overall it's a very pleasant watch.
The film starts very promisingly. A few men in suits, walking into the courthouse to the tunes of upbeat music. We see Special Agent Benedict Tisa (Corey Stoll) giving some last-minute advice to Jim Hoffman (Jason Sudeikis).
Nerve-wracking times are ahead for Hoffman. Why? Well, because Tisa caught him with a massive amount of drugs and a pile of unfilled taxes. This could be the beginning of Hoffman's time behind bars… if it wasn't for a secret deal with Tisa.
He walks free if he snitches on multiple people who were involved in the drug deal. 'A drugs dealer making a deal with an FBI agent. Where is DeLorean coming in?' Let us tell you. John DeLorean (Lee Pace) is one of the many people that are on the FBI wanted list. This would be the perfect opportunity for Tisa to catch him and for Hoffman to walk free.
After (strategically) moving next door to DeLorean, Hoffman is infiltrating his life, the world of decadence and luxury cars. It might be because of adoration and the need for friendship but mostly because Hoffman has his hidden agenda.
It will take a lot of patience and meticulously planned strategy to pull it off. How? Hamm will show you. From DeLorean and Hoffman becoming friends and starting their shady business to the FBI closing in on them and from the emotional impact this has on Hoffman's family to being caught up in a web full of lies and betrayal.
Who will walk away with the brand new car, the biggest amount of money and most importantly as a free man and who will sadly have to face time in jail?
The story about DeLorean is more than about manufacturing brand new and unique cars. It's a thrilling one in which politics, drugs, a lot of money and undercover operations collide.
What a shame that the story in "Driven" becomes a little bit too bland and we get that 'yes, we've seen it all' feeling. When it comes to the storyline, this movie could have benefited from much more horsepower. The unique idea is there, the written story not for a full 100%.
We have to admit that, despite that average story, we enjoyed this movie. More than we should have. There are a handful of reasons why "Driven" is worth the watch.
We don't know how many actors would get away with wearing an (obviously) fake wig and moustache but Sudeikis ("Booksmart", "Colossal") is certainly one of them. Just as always he's pleasant and charming to watch as the amiable guy next door.
The fact that Hoffman is leading a double life gives Sudeikis the chance to be even more funny and witty. Another reason or better said another person that brings the best out of Sudeikis is Pace ("Captain Marvel", "Guardians of the Galaxy").
He just oozes that 'I'm the man' vibe as the typical businessman with the American dream, multiple pool parties, and many wives. Pace puts DeLorean and his egocentric attitude on screen with a lot of charisma, skill, and attitude. Even when this movie seems to be running out of gas, it's the chemistry between Sudeikis and Pace that keeps it going.
Stoll ("The Seagull", "Ant-Man") joins those wonderful actors with his fine acting as the determined and on-edge special agent who's certainly not afraid to play a dirty game.
To make sure that "Driven" isn't only filled with boys and their toys, there's female power in the form of Judy Greer ("Ant-Man", "War for the Planet of the Apes"). Her role as Hoffman's nagging wife might be a bit of an ungrateful role but she still shows us an emotional acting performance.
What makes from this film one that doesn't take itself too seriously is without a doubt the clothes and props. Wigs in many different colours, many clothing styles that don't make any sense and flashy glasses just for the show. It might seem like a bit over the top but it fits into "Driven" perfectly.
Even more so because of the setting of the story. Hamm takes you to southern California in the '70s and '80s during which sunshine, happiness, and good vibes were present. All the excessive clothing and gadgets were probably just fashion during that time.
We also have to mention the cinematography from Karl Walter Lindenlaub ("Revolt", "Nine Lives") and music by Geronimo Mercado ("Speed Kills", "Sacred Family"). Right from the start, they draw us to the screen with very craftily made wide shots and an upbeat and thrilling score.
Earlier this year, DeLorean came to the big screen in the documentary "Framing John DeLorean". If you still want to know more about the egocentric man behind one of the most fascinating cars then you're in luck.
Thanks to Hamm, you can now again relive the American dream DeLorean had (and what eventually really happened). The story itself doesn't get faster than the 2nd gear. Once Sudeikis, Pace and Stoll come together, "Driven" certainly accelerates in the right direction.
"Driven" is in cinemas now and is available via digital download.
Intense thriller where politics, big business and narcotics collide.
Nick Hamm
Colin Bateman
Colin Bateman, Jason Sudeikis, Judy Greer, Lee Pace, Nick Hamm


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Home » Firm behind BlueIndy car-sharing service kicked to curb in Paris
Firm behind BlueIndy car-sharing service kicked to curb in Paris
June 22, 2018 | Bloomberg News
Keywords Automotive / BlueIndy / Distribution & Logistics / Government / Government & Economic Development / Local Government / Transportation
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Paris was a pacesetter in shared transport, launching Velib, the first large-scale urban bike share, in 2007 and an electric-car system called Autolib in 2011. Now, both ventures have skidded off course.
The city of Paris and other local governments on Thursday canceled their contract with Autolib's operator, Bollore SA, after the company predicted losses totaling 300 million euros ($348 million) over the next five years and asked for taxpayers to pick up much of the cost. Users also complained about dirty, poorly maintained cars.
Bollore, a French conglomerate that also manufactures Autolib's 4,000 electric minicars, still wants to find an agreement to keep the system operating, the company said in a statement late Thursday.
The dispute could raise questions about the viability of car-share programs that Bollore supplies in several other cities, including Indianapolis. Bollore is the parent company of car-sharing service BlueIndy, which launched in Indianapolis in September 2015.
A spokesman for Bollore said its car-share programs in other cities were functioning well and continuing to grow. Bollore also operates car-sharing services in Los Angeles, and Singapore.
Velib has suffered an even more humbling fall. As recently as last year it was one of the world's biggest and most popular bike shares. With daily ridership topping 100,000, it inspired similar programs across Europe and the U.S. But with the operating contract held by French advertising giant JCDecaux SA expiring, local governments chose a new vendor, a startup called Smovengo that ran smaller bike-share systems in about two dozen European cities and promised more electric bikes and other innovations.
The new operator has struggled, though. By January Smovengo had managed to get fewer than 100 stations in operation around the city and suburbs, compared with 1,200 previously. The number has since increased to more than 700, but in the meantime dockless bike operators such Ofo and Mobike have moved aggressively into the city, often parking rows of cycles near empty Velib stands. Smovengo has blamed the delays on technical problems and on legal disputes with former operator JCDecaux. Smovengo declined to comment.
The woes of Autolib and Velib are a blow to Paris Mayor Anne Hidalgo, who has tried to tackle air pollution by encouraging people to use bikes and electric cars instead of gas- and diesel-powered vehicles.
The debacle also holds lessons for other cities, said Adam Cohen, a research associate at the Transportation Sustainability Research Center at the University of California in Berkeley.
Autolib, which lets users pick up and drop off electric cars at charging stations around the city, "is one of the most challenging models" for car sharing, Cohen said. Infrastructure costs are higher because electric vehicles require charging stations. With one-way rentals, such stations have to be built at multiple locations. And cars remain out of service for hours while being charged — unlike conventional vehicles that can be rapidly hired out to other users.
"All of these things create a lot of financial strain on the system," Cohen said.
Autolib operator Bollore, owned by French billionaire Vincent Bollore, had asked local governments to help cover a projected 46-million-euro annual deficit until 2023 when its contract originally was set to expire. Paris officials pushed back, saying they had received inquiries from other automakers who could provide the service without subsidies. Among the companies expressing interest: Renault SA, PSA Group, BMW AG and Daimler AG.
It's unclear when the Autolib cars will disappear from Paris's streets. While Bollore said it hoped to still be able to find an agreement with the local governments, the city said discussions are under way with the company to determine a date to end the operation. Paris will seek to rapidly develop new car-sharing services and the city has had "very constructive discussions" with automakers, rental companies and startups in recent days, it said.