During these economically challenging times for public libraries, authors José-Marie Griffiths and Donald W. King provide arguments for continued public funding and support in A Strong Future for Public Library Use and Employment. Libraries have weathered recessions before and have shown consistently that when revenue sources decline, operational adjustments are made to deal with fewer resources. In addition, public libraries provide services that are particularly needed during recessions, so the use of many services increases. Griffiths and King use evidence from Institute of Museum and Library Services (IMLS) studies, statewide return-on-investment data, and survey results to demonstrate the value of public libraries. The book synthesizes research from many sources and provides easy-to-understand statistics, charts, and graphs, all of which are valuable advocacy tools for explaining—to boards, funders, stakeholders, and the public—why libraries still matter.
Further, the book contains a comprehensive assessment of public librarians' education and career paths to date and includes trends in public library employment, such as staff structure and educational level of staff. Early chapters highlight expanded service trends and increased library visits (both in-person and online) during economic recessions. The authors' studies show that, interestingly enough, a rapid increase in online visits has not negatively affected the number of in-person visits and may actually increase them—important data to present to those who say libraries are no longer relevant!
The second half of the book details public library employment trends. During the past three recessions (1980s, 1990s, and 2000s), the number of MLS-level librarians increased, and staff structure remained relatively consistent, yet the type of work done by MLS librarians decreased in reference and research services. Although this information is certainly of interest, the real value to public library administrators, library schools, and the ALA is contained in chapter 8's ten-year forecast of the number of MLS librarians in the workforce. Measures used to forecast include the number of MLS librarians who are expected to remain in the workforce, the number lost through attrition, and the number of current vacancies. These data come from a variety of sources, such as economic models, census information, surveys, and IMLS studies. The authors admit that forecasting is challenging, but results may be used to benchmark for future testing.
Public libraries face the same challenges during recessions that other organizations face: decreased funding, stretched staffing, and the need to do more with less. According to the authors, the current recession is unlike previous recessions in that federal, state, and local funders have accumulated substantial deficits that may require greater cuts and extend the length of the recession. So the question is: how will libraries fare? The answer is up to us.
This book offers useful research from multiple sources and provides valuable tools for advocacy and planning. Using data about trends and funding during previous recessions, the authors help libraries face the challenges of this extended recession. A Strong Future for Public Library Use and Employment belongs on the shelf of every public library administrator and should be shared with public library board members and staff.


GastroGeography of Singapore is an art collective that brings local Singapore flora to the table. During your time with them, the artists Lita and Steve will describe the art project and the edible food discoveries made in urban Singapore. With the artist collective, they have catalogued the spices, fruits, flowers, roots and plants found around the central city, and at every stop you'll have the opportunity to taste personalised samples of the same flora from their kitchen – cook, boiled, blended, fried, or in their purest form.
Part gastronomy, part geography, this food experience was part of the prestigious Singapore Biennale 2016. It is an opportunity for native food discovery and is a botanical treasure trove that intermingles Singapore's natural ecosystem with fragrance and flavours.
Food items are served as degustation pieces in individual tasting vessels. Each item on the menu is available in limited edition, being a vivid work of art unto itself. Vodka-based cocktails infused with the energy of crystals and native flora match the colour of the menu. Fitting the botanical theme, the entire menu is vegan and vegetarian.
Tucked away behind a tree-dense condominium on Arcadia Road, Lita's contemporary apartment is an oasis from the busy streets of Singapore. The decor within speaks of her openness to all cultures and a love for plants and nature. Her balcony filled with local flora which she nurtures and uses in her recipes, and in the evening, guests can enjoy the breeze coming in through the leaves.


Pipeline Emergencies will produce significant safety results in terms of industry, public safety and improved emergency response tactics. It is based upon nationally recognized engineering practices, recommended operating procedures, and training programs.
The Program includes a textbook, DVD and facilitator's guide with interactive pipeline training scenarios. This is the third edition of the program which was completely updated and released in January of 2017. Also, in 2017, the field education (IE classroom) component of the program underwent a third major content review and update to keep the content current given recent issues and events, yet still maintaining its balance with NFPA 472 and 1072.
As the demand for energy continues to grow, so too will the need for pipelines. While pipelines may become a controversial issue, this should not keep responders from training on this high-risk, low frequency event. The scenarios included in the program are designed to cover a wide range of potential incidents, while allowing responders to work through them using the resources available to them, thus allowing them the tools they need for their individual toolbox should such an event occur in or near their jurisdiction.
If you would like to purchase textbooks please visit our online store HERE.
To discuss in-person training opportunities please contact admin@firemarshals.org or call 202-737-1226.


Chance The Rapper recently announced some big news in a unique way.
On the newly released "I Might Need Security," which serves as one of four new tracks released late on Thursday (July 19), Chance revealed he bought the Chicagoist website.
The three-time Grammy winner went on to confirm the lyric in a statement.
Back in November 2017, both Chicagoist and DNAinfo were suddenly shut down by their publisher, Joe Ricketts. The move came a week after employees voted to unionize.
The Chicagoist currently only features archived content.


text:
La Beechcraft King Air es una familia de aviones de doble turbohélice diseñados y producidos por el fabricante aeronáutico estadounidense Beechcraft. Se trata de un desarrollo de la aeronave Beechcraft Queen Air, de la cual se distingue principalmente por el cambio de planta motriz, así como en la incorporación de un fuselaje presurizado.

Diseño y desarrollo

La línea King Air comprende una serie de modelos que inicialmente se dividieron en dos familias: el Model 90 y el Model 100, que se conocen como King Air, mientras que los Model 200 y 300 fueron comercializadas como Super King Air, aunque en 1996 pasaron a denominarse King Air. Del King Air se han llegado a desarrollar también numerosas versiones, tanto para uso civil como militar. Entre las versiones militares están el Beechcraft U-21, una versión híbrida no presurizada, desarrollada específicamente para el Ejército de los Estados Unidos, mientras que los VC-6 y T-44 son versiones derivadas del Model 90. Bajo la denominación Beechcraft C-12 Huron están las versiones derivadas de los Model 200 y 300. Entre los derivados civiles se encuentran los Beechcraft Model 99 y Beechcraft 1900, que son variantes específicas para la aviación comercial.

King Air 90

El desarrollo del King Air 90 se empezó a concebir en el año 1961. En mayo de 1963, Beechcraft dio comienzo a los vuelos de pruebas de una versión de desarrollo, modificada a partir de una aeronave Queen Air, a la que se le añadieron los motores Pratt & Whitney Canada PT6A-6, y que se denominó como Model 87. El 14 de julio, Beechcraft anunció su lanzamiento, y un mes más tarde comenzó a aceptar pedidos para esta versión inicial del King Air, comenzándose las entregas en otoño de 1964. El 24 de enero de 1964, realizó su primer vuelo el prototipo de una variante mejorada, denominada Model 65-90, también equipada con motores PT6A-6. El primer avión de producción se entregó el 8 de octubre, y al final de ese mismo mes, Beechcraft había recibido 152 pedidos de esta variante.

En 1966, después de haberse fabricado 112 unidades del Model 65-90, la producción dio paso al Model 65-A90, equipado con motores PT6A-20.
 NASA

 Fuerza Aérea Iraquí: usado para entrenamiento.

 El "Departamento de Aviación Civil" operó un C90 King Air una serie de años, pero ahora opera un Model 200 Super King Air.
}}

Civiles

Además de su uso por operadores militares y gubernamentales, el King Air también es usado por muchas organizaciones no gubernamentales, así como por operadores privados y corporativos. Incluye el uso comercial por compañías de aerotaxi y chárter.

El Royal Flying Doctor Service operó previamente una gran cantidad de King Air Serie 90, pero retiró el último ejemplar en 2006, estandarizando con el King Air Serie 200 y el Pilatus PC-12 sus requerimientos de flota.

Accidentes

 La tarde del domingo 24 de mayo de 1981, un Beechcraft King Air (FAE 001A) de la Fuerza Aérea Ecuatoriana (FAE), que transportaba al presidente Jaime Roldós Aguilera (había sido adquirido recientemente como avión presidencial), se estrelló contra el cerro de Huayrapungo ("Puerta de los Vientos", en quechua), en la Provincia de Loja. Además del Presidente, murieron todos los pasajeros de la aeronave: su esposa Martha Bucaram, el ministro de Defensa Marco Subía Martínez, Irlanda Sarango, los Tenientes Coroneles Héctor Torres y Armando Navarrete, el piloto y edecán del presidente, Teniente Coronel Marco Andrade, el copiloto Teniente Galo Romo y la azafata Soledad Rosero. La aeronave había salido de Quito poco después de una ceremonia cívico-militar en el Estadio Olímpico Atahualpa, en donde se condecoró a los combatientes de la Guerra de Paquisha. Su destino era la localidad fronteriza de Macará, en donde el Presidente debía tomar un helicóptero que lo trasladaría al cercano pueblo de Zapotillo, donde tenía previsto participar en otra ceremonia. Debía volver a Quito esa misma tarde, para la sesión solemne del Consejo Provincial de Pichincha.
 El 7 de diciembre de 2009, un King Air de la serie 90 colisionó durante la aproximación al aeropuerto de Egelsbach, Hess (Alemania). Al entrar en un banco de niebla, el piloto perdió la visibilidad, descendiendo a demasiada velocidad hacia la pista del aeropuerto. Después de varios toques en el concreto, perdió el control y se salió de la pista, estrellándose en una zona arbolada. Murieron el piloto y los dos pasajeros. El informe del accidente determina como causa principal el fallo humano durante las maniobras de aproximación y descenso, favorecidas por la ingesta de alcohol.
 El 25 de octubre de 2010, el Beechcraft King Air 100 con número de vuelo KBA103 y operado por Kenn Borek Air, se estrellaba en las proximidades del Aeropuerto de Kirby Lake en Alberta, (Canadá), durante las maniobras de aproximación. El avión había salido del Aeropuerto de Edmonton City Centre en Alberta (Canadá). La escasa velocidad en el planeo, con falta de sustentación y el fallo de la alarma de entrada en pérdida fueron determinantes en el accidente. Falleció el piloto. Otro miembro de la tripulación, así como los ocho pasajeros, resultaron heridos de diversa consideración.
 12 de marzo de 2014, un Beechcraft King Air C90 adaptado como ambulancia, construido en 1977, con cinco personas a bordo, colisiona 15 minutos después del despegue. El vuelo había partido del aeropuerto de El Dorado de Bogotá con destino a Araracuara (Caquetá). Tras comunicar problemas técnicos a la torre de Villavicencio, el avión perdió velocidad durante la aproximación y se estrelló. Murieron todos los ocupantes.
 El 19 de marzo de 2015, un Beechcraft King Air B90, operado por Taxi Aéreo Aviajet, se precipitó en las aguas de la laguna del Sauce, en las inmediaciones de la ciudad turística de Punta del Este, al sudeste del Uruguay. En el vuelo viajaban dos tripulantes y ocho pasajeros (siete argentinos y un portugués). Poco después del despegue, los dos motores comenzaron a arder y el avión entró en pérdida, precipitándose en la laguna. En este accidente no hubo supervivientes.
 El 4 de diciembre de 2016, un Beechcraft King Air C90, matriculado en Estados Unidos, se estrellaba en España entre los términos municipales de Sotillo de las Palomas y Segurilla (Toledo). El vuelo privado había partido desde el aeródromo de Cuatro Vientos de Madrid, y tenía como destino Cascais, (Portugal). Sus cuatro ocupantes murieron en el acto.
 19 de diciembre de 2019, un Beechcraft 100 King Air de uso civil se estrella a unas 5 millas del Aeropuerto Caracas, en Charallave, debido a las malas condiciones climáticas, con un saldo total de 9 personas fallecidas, incluyendo tripulación; no hubo supervivientes.

Especificaciones (B100)

Aeronaves relacionadas

Véase también

 Anexo:Aeronaves y armamento del Ejército del Aire de España
 Anexo:Aeronaves históricas del Ejército del Aire de España
 Anexo:Aeronaves de la Fuerza Aérea de los Estados Unidos (históricas y actuales)

Referencias

Bibliografía

 Kaminski, Tom. "Variant File: US Military King Airs: Part 1 Beech/Raytheon U-21 and C-12". International Air Power Review. Volumen 11, Invierno 2003/2004. ISBN 1-880588-60-9. ISSN 1473-9917. pp. 74–93.
 Kaminski, Tom. "Variant File: US Military King Airs Part 2: C-12". International Air Power Review. Volumen 12, Primavera 2004. ISBN 1-880588-77-3. ISSN 1473-9917. pp. 90–98.
 Jackson, Paul.  "Beech King Air B200." Jane's All the World's Aircraft 2003-2004, 2004. ISBN 0-7106-2537-5.
 Phillips, Edward H. Beechcraft - Pursuit of Perfection, A History of Beechcraft Airplanes. Flying Books, Eagan, Minnesota 1992. ISBN 0-911139-11-7.
 Simpson, R.W. Airlife's General Aviation.  Londres: Airlife Publishing, 1991. ISBN 1-85310-104-X
 Taylor, M. J. H. ed. Jane's Encyclopedia of Aviation Studio Editions Ltd. ISBN 1-85170-324-1

Enlaces externos

 National Museum of the US Air Force – Beechcraft VC-6A.
 Línea temporal del Beech King Air por Wings of Kansas.

0087 King Air
Aeronaves de ala baja
Aviones tractores bimotores
Aeronaves bimotoras turbohélice
Aeronaves civiles utilitarias de los Estados Unidos de los años 1960
Aviones entrenadores militares de Estados Unidos de los años 1960
Aviones de transporte militar de los años 1960 de los Estados Unidos
Aviones utilitarios militares de los Estados Unidos de los años 1960
Aeronaves de primer vuelo en 1963

redpajama_set_name: RedPajamaWikipedia


text:
Prince Edward in Marianske Lazne
https://english.radio.cz/prince-edward-marianske-lazne-8629675#player=on
Prince Edward, photo: CTK
The renowned Czech spa town of Marianske Lazne, traditionally known as Marienbad, was on its feet on Monday morning, awaiting the arrival of a British Royal. Prince Edward, the Queen's youngest son, is paying his very first visit to the Czech Republic and he headed straight for Marianske Lazne.
Marianske Lazne is a town that is long accustomed to royal visits - kings, poets and emperors wined, dined and hunted there, soothing their ailments with the curative spa waters. One of those who contributed to the town's development was none other than Prince Edward's great great grandfather, King Edward VIIth.
As a goodwill ambassador for his country, Prince Edward is attending a tournament of the Royal Golf Club in Marianske Lazne, which Edward VIIth opened exactly a century ago. Robert Simpson was in charge of organizing the royal visit and I was able to contact him in Marianske Lazne, shortly before the Prince's arrival:
The Prince is arriving from London today and will be coming directly to the Golf Club. They will be out on the course as the prince arrives and he will greet each individual player competing in the tournament. Then he is expected to visit the newly designed club house that his great-great-grandfather King Edward VIIth inaugurated in 1905. So it's the 100th anniversary of the Golf Club."
What is the mood like at the Royal Golf Club now? This must be a significant event for the town.
"It's actually fascinating. I arrived last night and the whole town is talking about this visit. There's electricity going on here. They are very excited about the fact that the Prince is coming and I think it is really good for the town and the people who live here, they are very excited about it."
You mentioned that the Prince's great-great-grandfather King Edward VIIth opened this very golf club. Do you know how that came about?
"Well, from what I understand, he liked this town. He used to come here to hunt. He liked the air and the spa, the fact that the waters are very special here. That's why he came here and I guess that's how the golf club came into existence - due to his influence."
I understand that the Marianske Lazne Golf Club has also been given the privilege - by the Queen - to use the title "royal". How many such clubs are there?
"As far as I know, there are only two golf clubs outside of Great Britain that have that title."
The second day of Prince Eduard's goodwill visit will be spent in Prague where he will hand out awards to the Czech winners of Duke of Edinburgh Youth Programme and meet with Second World War veterans who fought in the RAF.
Author: Daniela Lazarová
Duke of Edinburgh Award presented to over sixty young people at Czech Senate
Prince Edward awards young Czechs

redpajama_set_name: RedPajamaCommonCrawl


The International Journal of Angiology is a peer-reviewed journal dedicated to the diagnosis, treatment and long-term management of vascular and cardiovascular disease. A multidisciplinary journal, it publishes original research, reviews, case reports, and rapid communications on all aspects of angiology. Articles published cover experimental, clinical and basic science; as well as the outcomes of medical research and clinical trials.
A key publication for all those working in cardiovascular medicine and surgery, the International Journal of Angiology will be of interest to cardiovascular surgeons, vascular surgeons, interventional cardiologists and radiologists, neurosurgeons, internists, cardiology researchers and general physicians.
The International Journal of Angiology is the official journal of the International College of Angiology, and as such is distributed to all members as part of the membership package. The society is committed to improving health and quality of life through the practice of vascular medicine and surgery, and supports extensive research and educational programs.
The International Journal of Angiology is also an official journal of the International College of Surgeons and the Asian Society for Vascular Surgery. The International Journal of Angiology is available in print and online. Articles published ahead of print are available via the eFirst service on the Thieme E-Journals platform.


Area of North Waziristan Agency, on the border between Pakistan and Afghanistan and part of Federally Administered Tribal Areas of Pakistan, is perhaps one of the most dangerous areas in the world. Dandey Darpa khel village lies about five Kilometres north of Miranshah town, administrative headquarters of the North Waziristan Agency. This sleepy village and surrounding areas were once the hub of a terrorist network known as the Haqqani network, led by Pakistani Taliban or Tehreek-e-Taleban Pakistan (TTP) leader Hakimullah Mehsud, a militant faction blamed for some of the most high-profile attacks in Afghanistan in recent years. Hakimullah Mehsud, was killed by a United States drone strike in first week of November 2014.
In spite of his being killed, Mehsud continued to be a hero with his followers in this region. His followers considered it a duty or a honour to keep distinctive long-haired, bearded look and flowing hair locks, just like him. The trend had become so common that, when we think of a person believed to be a terrorist, we naturally assume that he would have a long-haired, bearded look. Over the years, Taliban have terrorised people of north Vaziristan by bombing and maiming thousands of people in their fight to install an austere syariah regime in Pakistan.
Pakistan's federal Government have been trying to open a dialogue with North Vaziristan terrorists for quite some time now. However things have only changed from bad to worst. Pakistani army finally told the Government that they have decided to move in north Vaziristan for the final push to solve the problem once and for all. The recent attack on Karachi airport by terrorists is believed to be in response to the Pakistani army's likely offensive.
However, as the news of imminent Pakistani offensive in North Vaziristan broke out, there was wide spread panic for the ordinary people of North Vaziristan and nearly half a million fled, some to Afghanistan, after crossing the border. Thousands of refugees have poured across the lawless border into ramshackle camps on rugged hills in Afghanistan. Afghan Authorities in Khost province are offering a warm welcome and do whatever little they can to shelter the newcomers.
However their principal worry is that of Taliban militants may be hiding amongst the refugees. Afghan intelligence officers and the army are uneasy because some refugees from North Waziristan province could be actually Islamist activists of the Pakistani Taliban, the target of Pakistan's offensive. It appears that their worry is based on real facts because of the conformation, that has come from somewhere else.
Most of the people who have fled North Vaziristan have actually moved to Bannu, the principal city of the Bannu District in adjoining Khyber Pakhtunkhwa province of Pakistan. About 70% of them are possibly women and children. It is not known whether the displaced people, who include 86 Hindu and Christian families, would be able to return from their camps in Bannu town to their homes. The displaced Hindus and Christians have taken shelter in two missionary schools in the town—Janbaz Catholic Missionary School and Pannell Missionary High School.
I find this very interesting from human behaviour point of view. With the fear of real Pakistani army onslaught on them, these fundamentalist terrorists, who earlier wanted to impose an austere syariah regime on others, actually wanted to suddenly change their appearance, which proves that the fear is the real key to our behaviour even for a terrorist.


text:
Suicidal Man Who Climbed Lekki Electric Cable Was Allegedly A Thief
A Cameroonian, Frederick Gino, was yesterday rescued from committing suicide on a high tension electric pole in Lagos.
The incident, which occurred on Adebisi Ogunniyi Crescent in Lekki Phase One, Lagos around 5:30am attracted motorists and passersby, who called the Fire Service through the emergency toll free numbers.The man was sighted on the pole around 5:30am, and all the efforts to get him down failed. IF YOU MISSED, READ HERE
According to The Nation, he was said to have climbed the pole to avoid being lynched after he was allegedly caught in an attempted burglary.
He was said to have gone up the pole following disconnection of light by the Eko Distribution Company. Gino was said to have attempted to harm himself when operatives of the fire service, Lagos State Emergency Management Agency (LASEMA), the police and the Nigerian Security and Civil Defence Corps (NSCDC) arrive to bring him down.
The Nation gathered that he was injured while been rescued and taken to Oba Yekini Eleguishi Health Centre in Lekki. According to a witness, the Cameroonian said he did not know how he got to Nigeria. He claimed that the victim climbed the pole after he was caught attempting to burgle a nearby mall.
"It is not a suicide attempt. The guy is a thief. He wanted to burgle a mall in the neighbourhood but he was caught and chased. He fled and climbed the electric pole for fear of being lynched.
"He didn't get the close to the cable until Eko Distribution Company was contacted to isolate the area. Even at the hospital, he wanted to run but he was pinned down. He later started begging that he was hungry and needed food. That he has nowhere to go," said the eyewitness.
LASEMA General Manager Michael Akindele said; "Security operatives will conduct proper investigation on the matter. People should be watchful, observe strange faces and other activities around them. Such incidents should also be reported to security agencies or a call placed to either 767


text:
Q: Exibição de uma tabela mysql na página html Bom dia amigos!
Pesquisando, consegui juntar esse código da página 'mostratestem' para expor o conteúdo  da tabela 'testemunho' do BD 'beja_provida'. Todavia, não da o resultado esperado. Alguém me da uma luz, por favor?
Codigo:

    <!DOCTYPE HTML>

  <title>ListaTestem</title>

Exibir dados com PHP/MySql

<?php

$servidor = "localhost"; /*maquina a qual o banco de dados está*/
$usuario = "root"; /*usuario do banco de dados MySql*/
$senha = "joanin21"; /*senha do banco de dados MySql*/
$banco = "beja_provida"; /*seleciona o banco a ser usado*/

$conexao = mysqli_connect($servidor,$usuario,$senha);  /*Conecta no bando de dados MySql*/

mysqli_select_db($banco); /*seleciona o banco a ser usado*/

$res = mysqli_query("SELECT * FROM testemunho ORDER BY nome")or die (mysqli_error($escrever); /*Executa o comando SQL, no caso para pegar todos os usuarios do sistema e retorna o valor da consulta em uma variavel ($res)  */

echo "

ID	Nome	E-mail	Testemunho
";

/*Enquanto houver dados na tabela para serem mostrados será executado tudo que esta dentro do while */
while($escrever=mysqli_fetch_array($res)){

/*Escreve cada linha da tabela*/
echo "
" . $escrever['id_testem'] . $escrever['nome'] . "	" . $escrever['email'] . "	" . $escrever['testemunho'] . "
";

} /*Fim do while*/

echo "
"; /*fecha a tabela apos termino de impressão das linhas*/

mysql_close(conexao);

?>

Resultado:

O HTML que chama a página 'mostratestem' é esta:

<!DOCTYPE HTML>

 <meta charset="UTF-8">
 <title>Savino</title>

 <link href="//netdna.bootstrapcdn.com/font-awesome/3.2.1/css/font-awesome.css" rel="stylesheet">
 <link href="//netdna.bootstrapcdn.com/twitter-bootstrap/2.3.2/css/bootstrap-combined.no-icons.min.css" rel="stylesheet">
 <link rel="stylesheet" href="provida.css">

TESTEMUNHOS

" o Reino de Deus è a coordenação de todas as forças positivas que existem no mundo a fim de que consigam transformar a vida numa nova e apreciável realidade sem dores, sem fome, sem guerras, sem doenças
e   nenhum   outro   mal.".
(Savino Mombelli)

Savino
Histórico
Reflexões
Imagens

 <form action="testemunho.php" method="post">
            Nome: <input type="text" name="nome" size="50" />

            Email: <input type="text" name="email" size="50" />

   Testemunho: <textarea name="testemunho" rows="10" cols="100"></textarea>

            <input type="submit" value="Enviar"/>
        </form>
        <?php include("mostratestem.php"); ?>

  *
Veja os testemunhos registrados

*

PÁGINA EM COSTRUÇÃO

A: Eu estava passando por este problema, mas agora consegui resolver há alguns dias e vou postar meu código aqui é uma tabela com dados trazidos do banco de dados, e desta forma eu tiro somente o cabeçalho do PHP e deixo dentro do HTML mesmo. Meu include no arquivo conn.php é feito pois, este arquivo que faz conexão com o banco de dados.
index.php ( teste isso com valores do seu Banco de Dados )

  ID
  Código Produto
  Tipo
  Descricao

<?php include("conn.php");

$sql_tipo = "SELECT * FROM tipoprod";
$resulta = $conn->query($sql_tipo);

if ($resulta->num_rows > 0){

    while ( $row = $resulta->fetch_assoc()){

        echo '
';
        echo ''. $row['id'] .'	';
        echo ''. $row['codigo_produto'] .'	';
        echo ''. $row['codigo_tipo'] .'	';
        echo ''. $row['descricao'] .'	';
        echo '
';
    }
}
?>

conn.php
<?php
$servername = "localhost"; /* nome da conexão */
$username = "root"; /* nome do usuario da conexãp */
$password = ""; /*senha do banco de dados caso exista */
$dbname = "teste123"; /* nome do seu banco  */

// Create connection
$conn = new mysqli($servername, $username, $password, $dbname);
// Check connection
if ($conn->connect_error) {
die("Connection failed: " . $conn->connect_error);
}
?>

redpajama_set_name: RedPajamaStackExchange


text:
Buy Side Ramps Up Risk-Management Spend
The asset management community is bullish on risk management investments as approximately three-quarters of buy-side firms look to evaluate or implement new risk platforms in the next 12 months, according to recent research from Greenwich Associates.
Although overall technology spending by asset managers have been relatively flat for the past few years, spending on the risk management has grown, Kevin McPartland, managing director, market structure and technology at Greenwich Associates, told Markets Media.
"We were surprised at the increase in spending we found," he said.
The buy side spent an estimated $692 million annually on risk, which represented 6% of its overall IT spending in 2017, McPartland wrote in a recently published study. Greenwich predicted that that would increase to approximately $700 million, or roughly 10% of overall spending, in 2018.
McPartland attributed the rise in spending to a sea change amongst asset managers.
Kevin McPartland, Greenwich Associates
"Right after the financial crisis, spending was cut everywhere except for risk management," he said. "Here we are ten years later, and the jump in risk spending is not about fixing what broke during the crisis. It is about increasing returns and getting into new markets."
If the previous spending on risk was defensive then its offensive now, he added.
The search for better yield has led institutional investors to incorporate instruments that they have not used in the past into their portfolios, such as structured credit vehicles.
"To do that safely is to have the ability to model the risk and make sure that you are taking on the appropriate amount of risk for the risk that you are chasing," said McPartland.
Where and how the buy side plans to invest in their risk infrastructure remains a broad spectrum of approaches, but he noted a steady march towards third-party systems.
"Unlike EMS and OMS platforms a decade ago, when you bought it you bought the same thing as your competitor across the street, risk platforms are so customizable that one implementation does not look like the rest of them," said McPartland.
He also noted that asset managers are driving towards adopting standard platforms across their businesses to obtains a business-level view of their risk exposure.
"Firms will always have their star portfolio managers who need the tools they need to do what they do so firms will make exceptions," said McPartland. "Generally speaking, asset managers are trying to standardize and get away from that."


text:
Race, Politics and Hypocrisy in 21st Century America
Theresa May Resigns as British Prime Minister
May 27, 2019 May 25, 2019 James Edwards
The hateful, duplicitous, barren Theresa May resigned last week.
She droned on about all sorts of politically correct nonsense during her resignation speech, but the cherry on the cake was the crocodile tears that came at the end.
One of TPC's listeners in London wrote that she was the single most incompetent politician he ever had to suffer under.
She quit only because her handlers told her that she had done all she could to scupper Brexit and now they will put another traitor into #10.
Now she will become Dame Theresa May and will make a fortune sitting on many "no show" boards and commissions. Her hideous nose will be deeply in the trough.
Brad Griffin wrote this on the matter:
The UK has been governed by a childless old maid for the past several years who has been destroying the country, but we can now say good riddance to one of the worst Prime Ministers in British history.
I say one of the worst because Tony Blair, Gordon Brown and David Cameron also all presided over the current immigration disaster. I would rank Blair and Churchill ahead of May as worst PM of all time.
We knew that Theresa May was going to be a disaster when she spent her time as Home Secretary banning harmless Americans from traveling to Britain to attend conferences while throwing out the welcome mat for countless jihadists.
There came a point when I just gave up counting the number of terrorist attacks under May after one of them starred in "The Jihadis Next Door."
"Conservatism" has been a global disaster for our people. We're looking forward to seeing if the next PM can top the cringe we were treated to under May.
May, Macron, Trudeau, Trump, Obama, Bush, Clinton, Brown, Blair … this is it? This is the best we can do?
All of England is cheering!
Conservatism Is Dead
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Anti-Asian Discrimination
Suffolk County Bill Would Provide New Ways For Hate Crime Victims To Seek Justice
A new bill from the Suffolk County Legislature aimed at combatting anti-Asian hate would make it illegal to discriminate because of a perceived connection…
Conn. AG Tong Speaks At Anti-Asian Discrimination Summit
Connecticut Attorney General William Tong said the perception of Asian Americans as meek and docile needs to be confronted. He told a summit of states…
Proposed Nassau County Law Would Create New Penalties For Anti-Asian Discrimination
Charles Lane
Democrats in Nassau County are proposing a new law that would extend protections under the county's human rights law that would penalize anyone who…
Schumer Backs Anti-Asian Discrimination Bill
Senate Majority Leader Chuck Schumer from New York has thrown his support behind a bill to combat the surge in anti-Asian hate crimes during the COVID-19…
Asian American Pacific Islander Individuals Weigh In On Biden Discrimination Plan
Cassandra Basler
Members of Connecticut's Asian American and Pacific Islander (AAPI) communities say they are glad to see President Joe Biden's new plan to address the…
Virus Of Hate: 'We Are Not Your Fetish' — Combating Anti-Asian Racism And Sexism
Police have not said whether the killing of eight people in Atlanta, including six Asian women, was a hate crime. Still, the shooting is troubling many…
New England Rallies Planned In Support Of Asian, Pacific Islander Communities
Members of the Asian American and Pacific Islander communities in New England are gathering to remember the six women killed in Atlanta and call for an…
Tong Joins New Haven Rally In Support Of Asian, Pacific Islander Community
Connecticut Attorney General William Tong joined a coalition of local activists in New Haven on Thursday to stand up against attacks Asian Americans. The…
Suffolk County Creates Hate Crime Task Force In Wake Of Anti-Asian Attacks
Terry Sheridan
Suffolk County District Attorney Tim Sini has announced the creation of a Hate Crime Task Force to tackle bias-related incidents."Our nation is in the…
Connecticut Leaders Look To Halt Anti-Asian Discrimination And Other Hate Crimes
Members of the Asian American and Pacific Islander communities in Connecticut say people should not be surprised at the escalation of violence against…


So, I was at a Barbeque the other day and a situation occurred that, well, I'm getting tired of. It happens almost every time I meet a new group of people.
When you meet someone, eventually you come down to finding out what they do for a living.
I'm an engineer and work in the space industry, and after explaining that no, that doesn't mean I'm an astronaut and no, it's not as exciting as it sounds... I seem to end up as a go-to point for anything that they don't understand.
As an example from the weekend, I had to patiently explain why the flat earth movement is nonsense (sorry-not-sorry believers) due to concepts like gravity which I understand - this individual didn't, so I had to explain that.
Kids I'm fine with, it's adults who either weren't listening in school, or perhaps didn't get the education I did, that perceive "has a degree" as "knows everything and wants to discuss it at length at every opportunity".
I don't, I'm having some beers in the sun, and while I fully encourage people to learn more... I'm not a teacher.
How can I, as politely as possible, escape from these kind of situations without playing dumb?
It's a vicious cycle when answering one simple question leads to another, to another - and before I know it a group of people are hanging onto my every word until I run out of steam. It then becomes almost awkward to have a "normal" conversation afterwards - once someone sees you as a font of knowledge the balance of power shifts.
You need multiple strategies here.
First, be more precise about your job. "I work in the space industry" naturally makes people think you're an astronaut or a rocket scientist. "I'm in professional baseball" would make people think you're a player or a coach rather than an accountant, chef, or janitor. So if you develop software, say you develop software. If you're doing research on the Northern Lights, say you do research on the Northern Lights. And so on. You're the one who makes it about your industry by saying what industry you work in, rather than what you do.
Second, if you don't want to explain something, don't. Say someone tells you the earth is flat. You can simply say "I'm convinced it's round." If they argue, don't get into facts and proving. You can say "is it a matter of faith for you, or the word of someone you trust, or you've seen good evidence?" Then no matter which they answer, you can say "it's the same for me" (it will be for the case of a round earth, we have all those things) and then smile and say "enjoy the barbeque" and go to another part of the yard, or inside to get a drink, or whatever.
Third, if you are asked a question you can answer, and want to, pay attention to the asker to see if they want a short or long answer. If you personally only feel like giving a short answer, do that. You can even say "I can't give you the long answer here without a whiteboard, so the short answer is ..." and summarize simply.
Fourth, learn a little catchphrase. A chef I know says "I cook all day and night for work, don't ask me to talk about it too!" and while people laugh, it changes the subject nicely. You can come up with something similar if you're being asked to explain climate change or the like.
"sorry, I'm not a great teacher, but there are some really good explanations [of the basic concepts] online."
"sorry, I know too many trade secrets to be comfortable talking shop with outsiders."
"sorry, I answer technical questions all day at work and just want to relax at parties."
"enough about me, what do you do for a living?"
Make sure that you avoid saying anything that can be construed as "it would be a waste of time to try to explain it to you" even (or especially) if that's what you're actually thinking. This particularly goes for charged subjects like climate change, evolution, vaccination, or even plate tectonics, where you may be running into people who are more interested in reaffirming their commitment to one version rather than listening to actual information.
Interrupt them with a counter question or question about a similar but different topic, or find something else going on around and divert attention to that. This is probably the easiest way to get the focus off of you, where you could slip away or keep the conversation headed away from you.
If I were to go in depth into this topic it would take a lot of time. Right now I just want to (enjoy a beer, eat some food, etc).
Most people would understand that explaining things takes time and effort and won't be offended that you want to relax. They are just interested in learning.
Conversation at BBQs with strangers is all about small talk; these people are trying to make contact with you by showing an interest in your (obviously interesting) job. However they are usually not interested in the answer. They are interested in expressing their own opinion, and/or talking about themselves.
"You know, I just sit at my desk and stare at math formulas all day!"
"Oh well, we're not at work now right?"
"By the way, I really like your shirt. Do you play hockey?"
"I'm thirsty/hungry, can I get you something?"
It's okay not to return to the person if it's a busy BBQ but if not, return with the drink and then tell them you found an old acquaintance you need to catch up with.
Being an Audio and Software Engineer, I can kind of relate. Not so many people are as excited about my field but I do always end up with someone's phone in my hand, working as the free technician of the afternoon, which is extremely annoying in its own right.
Personally, I've found there is no real way around this when at a cookout or similar event without being a little blunt. For example, when someone tries to hand me their phone I simply offer them my email address and tell them to contact me when I'm not relaxing and I'd be more than happy to help them. This allows me to deny the immediate request without completely shutting them down.
When I run into those who want to discuss app ideas or which DAW is best for techno production and so on and so forth... I simply hit them with the same strategy, different dynamic.
Anyways, I hope this helps even a little. Best of luck to you.
I had a friend who was a dentist.
As you can imagine, he soon tired of that.
For the past 30 years he's been telling people who ask what he does that he's a biscuit designer.
Very few people have ever had a follow up question to that, beyond, 'did you design the oreo/hob-nob/rich tea?' etc. to which he would simply answer, 'No.' & the party continues.
This strategy, of course, works best when you are unlikely to ever meet these people again - much harder if it's a circle of friends, although a circle of friends ought to have got the message by now.
These problems are happening because you are sharing your potentially very interesting background. If it was me I would be more vague if I didn't want to talk about it too much, and deflect incoming questions.
You basically have two options for dealing with these kinds of problems; be direct, or be boring.
Oh I don't really want to talk about it. I just want to relax/forget about work/enjoy the party.
I already said I don't want to talk about it. Please respect my wishes.
I work on making sure that the equipment designed by my x company works as efficiently and predictably as possible, so we can reduce costs.
Oh that's interesting. Like what?
Usually I talk with my peers and together we try to think of things that might go wrong. We try and identify common problem that cost a lot of money, and make sure to avoid it. We have to be very precise and most of our time is spent crunching numbers. It sounds interesting but really it is not. We just do the same thing everyday.
You can choose your words differently, but the idea is to deflect as much as possible. You could also be extremely specific when they ask you what you do to the point it is no longer interesting. Basically your simple options are to be direct, or to be boring.
People will stop asking very quickly. You are not giving them any positive reinforcement, which is a concept from behavior analysis to reduce behavior. In ABA terms you would be punishing (reducing) the unwanted behavior by withholding the reinforcement (expected reward that motivates the action). You can read up on the science of this, if you want to understand how to implement this and other forms better.
To the person you are doing this to this is a very natural flow of circumstances that happens everyday. So it won't be rude.
Not the answer you're looking for? Browse other questions tagged conversations awkward-situations politeness or ask your own question.
What methods help to avoid "that awkward silence"?
How to talk to someone about being chronically late - not to fix it, just to get more accurate ETAs?
Attending the 9/11 Memorial next month - how to interact with families that lost loved ones?
How should I ask people to stop over explaining things?


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Tag: scientist
Medical experts and friends of JDRF awarded with Queen's Birthday Honours
JDRF and the Type 1 Diabetes Clinical Research Network (T1DCRN) are proud to congratulate Professor John Shine AO and Professor Peter Colman for receiving Queen's Birthday Honours this month. Read More
Tags : jdrf, Professor, Professor John Shine AO, Professor Peter Colman, researcher, scientist, T1DCRN, type 1 diabetes
T1DCRN awards $14 million for type 1 diabetes clinical research
The Type 1 Diabetes Clinical Research Network (T1DCRN) announced today that over $14 million in grants have been awarded to Australian researchers for clinical research projects commencing in 2016.
This funding forms part of the $35 million funding awarded to the T1DCRN by the Australian Research Council, and will support five innovative programs targeting a broad range of T1D research areas including: Read More
Tags : australia, childhood, clinical research, clinical trial, clinical trials, complications, cure, funding, jdrf, researcher, scientist, t1d, type 1 diabetes
T1DCRN researcher Maria Craig receives prestigious Professorship
"You have been amazing and a blessing for my son since he was diagnosed seven years ago".
"We are so blessed to have this amazing woman as our endocrinologist".
"She's been there since day one for us".
These are just a few of the things Maria Craig's patients and their families say about this popular endocrinologist. What her patients may not know is that Maria Craig is also one of Australia's leading researchers in the field of type 1 diabetes, and in January was conferred with the title of Professor of Paediatric Endocrinology by the University of Sydney and the University of NSW. This highly esteemed title was awarded to Professor Craig in recognition of her leadership in cutting-edge clinical research that is unravelling the causes of type 1 diabetes, and investigating possible ways to prevent it.
Professor Craig first developed an interest in type 1 diabetes research when she was a young medical student. "I volunteered for a children's diabetes camp and have never looked back", she said. She went on to complete her PhD in 2002, a Master of Medical Epidemiology in 2003, and is currently a paediatric endocrinologist specialising in type 1 diabetes at the Children's Hospital in Westmead. Professor Craig says JDRF has been instrumental in helping to establish her research career, "not only funding, but support, and facilitating meetings which in turn have helped to foster vital collaborations and connections". Read More
Tags : endocrinologist, maria craig, Professor, researcher, scientist, westmead


Advise and support the Chief of Party in the development and implementation of a comprehensive vision and strategy to improve forest and conservation area management under TT1, ensuring strong integration across BIJAK's four technical components.
Provide overall technical direction, strategy input, and leadership to project staff assigned to TT1, including defining and overseeing technical quality and schedule performance and coordinating short term technical assistance needs. This will require close and regular communication and collaboration with all relevant project staff, subcontractors, grantees, short term technical assistants, Government of Indonesia (GOI), USAID, and other donors and project partners.
Serve as direct supervisor of the Resource Rights, Governance and Policy Reform Specialist (Component 1) and Environmental Enterprise Development Specialist (Component 3), provide support and mentorship for senior technical staff in developing their strategy, and designing and managing project activities; assess their performance and provide feedback on a continual basis; provide training, coaching, and consistent feedback on technical team work products, presentations, and performance.
Support analysis, capacity building, and other technical assistance provided to GOI stakeholders to create a revised and updated legal, policy, regulatory and operational framework for improved conservation area and forest protection and management.
Develop strong evidence-based, compelling, and credible presentations to demonstrate overall TT1 strategy and activities/activity design justifications. Clearly and concisely articulate key messages, project successes under TT1, and strategic approaches through various communications outlets and publications (e.g. policy briefs, analyses, key activity highlights, activity summaries, etc.).
Contribute to monitoring, evaluation, and learning efforts and oversee and support the preparation of activity reports as required by donors and/or stakeholders, in Indonesian and English.
University degree(s) in Forestry, Environmental Science, International Development, Public Policy, Public Administration, Political Science, or related development field is required.
Must have a minimum of fifteen years of experience working on forest conservation and forest governance issues, including issues related to sustainable palm oil development, primarily in/with the GOI, or equivalent international development agency. Minimum 5-years' professional experience in Indonesia.
Existing networks within GOI agencies are a must and ability to liaise with and communicate effectively with senior government officials, donors, and partners is required. The candidate should also have strong private sector and civil society networks in relation to environmental protection, sustainable palm oil, forest governance, and protected area management.
Experience and a deep understanding of the process of policy and legal reform in Indonesia related to forest governance, forest conservation, sustainable forest management and the environment.
Demonstrated experience working with senior GOI officials, CSOs, and donors on forestry, sustainable palm oil and conservation management initiatives.
Experience with legislative drafting, policy formulation and advocacy, organizational capacity building, cross sector coordination, public engagement, and behavior change campaign activities preferred.
Good judgement, ability to work under tight deadlines.
Ability to maintain financial and technical control of projects.
to bijakrecruitment@gmail.com by October 10, 2017. Please put the code "BIJAK-TT1" on the submission email. Early submission of qualified CVs will be prioritized that might lead to early hiring process.


a joint in which the opposing bony surfaces are covered with a layer of hyaline cartilage or fibrocartilage within a joint cavity that contains synovial fluid, lined with synovial membrane and reinforced by a fibrous capsule and ligaments; and there is some degree of free movement possible.
A freely movable joint in which the contributing (joint-facing) bones are covered by an articular capsule enclosed in a cavity lined by a synovial membrane and filled with synovial fluid.
A joint in which (1) the opposing bony surfaces are covered with a layer of hyaline cartilage or fibrocartilage, (2) there is a joint cavity containing synovial fluid, lined with synovial membrane and reinforced by a fibrous capsule and ligaments, and (3) there is some degree of free movement possible.
Synonym(s): articulatio [TA] , diarthrodial joint, diarthrosis, movable joint.
of the nature of a diarthrosis.
Pain, lack of power, symmetrical synovitis of diarthrodial joints, destructive changes in joints, functional losses, as well as associated cardiovascular, neurological and metabolic problems may be observed in these patients.
Cartilage and diarthrodial joints as paradigms for hierarchical materials and structures.


A stylish navy blue mandarin collar shirt for trendy working women. The high collar elegantly slopes down into a V-neckline, followed by a button down slit. The triple buttons are stylized to give your everyday work wear a supreme dignity and elegance. It has a tailored cut and cuffed long sleeves.


Saint Leo University is committed to ensuring that all students have access to technology to support their educational pursuits . University Campus students including transfer students, Part-Time students, and commuters, may be eligible for the UTS Laptop Rental Program.
Availability for Rental Laptops is on a first come, first served basis. A deposit of $250 is required to rent a laptop. All available laptops meet the Saint Leo University Compliant Device Requirements.
If you have additional questions about the UTS Laptop Rental Program, please enter a helpdesk request. Technology Support Services office hours and contact information are also listed below.


If Iggy Pop had a skate doppelganger, this week's Monday Cover skater, Mark Partain, just might be it. Mark's agility and sinewy style continue to keep him in the upper eschelons of competitive skateboarding. Check out more pics of Mark dominating this year's Oregon Trifecta series after the turn. EPM "ain't got time to make no apologies" Out!
He just sneaks his tricks in. So Sneaky.
So cool to see ya sweep the trifecta this year!
Great shots Rich. Mark inspires a guy my age to skate harder. Ripper!!!!!
Tri-fecta 2011 I can't wait.
He skated the wall at the end of the LC snake run like it was a halfpipe. NUTS!
He looks kind of like Woody Harrelson there.
Cannibal Cyclops is Gonna Eat You!


Alphabet Bingo is a fun way for young learners to develop literacy skills and alphabet recognition! This easy-to-play activity is perfect for reinforcing what children have been learning during lessons – ideal for family fun at home or as an end of lesson activity!
The double-sided bingo game means two times the fun! Matching upper and lowercase letters and identification of initial letter sounds.
The game box includes: a spinner, four caption cards , four game cards, 36 disks and instructions.
Young learners will have fun while racing to be the first to cover a complete row on their game cards. For 2 – 4 players. Recommended for children aged from 4 years.


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PLC Trenching - Clinton, NY
PLC Trenching, LLC, based in Clinton NY, is a contracting company that owns, operates, and maintains specialty trenching and cabling equipment. In 2006, they contacted us to design and build their first building to maintain the equipment. This project, a 13,000 sf custom Butler building had (2) 10-ton bridge cranes, (4) 2-ton jib hoists, with a machine shop, wash bay, storage mezzanine, and support offices, lunch rooms etc.. They quickly outgrew that building and had us return in 2008 to more than double that space to add another 13,000 sf shop with (2) more cranes and jib hoists, as well as a 3,200 sf prep and paint booth that can handle up to 50' equipment. Later in 2008, we continued with a Butler custom-designed, conventionally framed 2-story 10,500 sf Office building attached to the original shop building.
The owner, Mr. David Critelli, wanted to use a "European" style in this building. The timing of the introduction of Butler's Azimuth siding system could not have come at a better time, as that was exactly the look he wanted, in a black color. We worked with our Architects, Alesia and Crewell, New Hartford, NY, to design the building around the Azimuth product and also to utilize the Koreteck wall system, which we have used on several projects. We included butt-glazed strip windows and solar shades to create the sleek look. The interior finishes also follow the European look using polished granite floor tile, manufactured aluminum and cherry wood partitions, cherry wood ceilings, stainless steel railings, specialty lighting, and very high tech furniture systems. The building also uses water source heat pumps for a multi zone energy efficient HVAC system.


Highland Park Tennis Association (HPTA) is an all-volunteer organization founded in October 2004. Our overall goal is to create and foster a safe, friendly environment in Highland Park where tennis can be enjoyed and flourish for generations to come.
Our mission is to utilize tennis as a vehicle to promote and instill the importance of education, social responsibility, healthy lifestyle, proper nutrition, fair competition, respect, high self-esteem and strong character to the participants of our Junior Tennis Program, while providing an alternative source of recreational outlet. With our strategic programming and dedication, we hope to prepare the participants of our program to face and conquer the challenges they may face in life.
Conveniently located on a high plateau that straddles Queens and Brooklyn, Highland Park offers stunning views of Ridgewood Reservoir, the Rockaways, the Atlantic Ocean, and nearby cemeteries.
HPTA's Junior Tennis Program, the centerpiece of the organization, is a tennis themed educational program that serves children 3-17 years of age with a unique blend of tennis instruction, academic enrichment and valuable life skills.
The East New York/ Cypress Hills neighborhood has a reputation of being tough with many of the same problems faced by similar mostly urban, minority neighborhoods. We heard too much about crime, substance abuse, obesity, teen pregnancy, and academic failure. But all that is changing, and Highland Park Tennis Association is playing a big part in the transformation.
Participants learn the rules of the game, etiquette, sportsmanship, positive attitudes, fair play, self-esteem, taking responsibility for choices, and management of emotions. These life skills are integrated throughout the tennis program, and instructors routinely demonstrate how they apply to situations in all aspects of life.
Since its inception, Highland Park Tennis Association's Junior Tennis Program has earned a positive reputation for providing constructive activities that contribute to reducing crime and illicit activity, increasing academic performance, and providing life skills to ensure success in school, in the community and in life.
Looking for Tennis in Brooklyn? Look no further!
Highland Park Tennis Association (HPTA) is non-profit 501(c)3. Donations are tax-deductible to the extent permitted by law.


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A DOSE OF SCIENCE
Regina Kelder
Antibody Screening in the Fast Lane
A next-generation tool that is changing the way therapeutic antibodies are discovered.
Thor, the protector of mankind, is a hammer-wielding god who swoops in to save the world. You could argue that monoclonal antibodies (mAbs) sort of serve the same purpose. Monoclonal antibodies (mAbs), which are manufactured in the laboratory and then cloned, produce custom-designed and uniform antibodies that can attach to specific disease cells — bacteria, viruses or cancer cells—without injuring healthy tissue.
Since 1986, when the US Food and Drug Administration approved the first mAb (in this case to limit organ transplant rejection) more than 70 therapeutic or diagnostic mAbs have been approved. Today, mAbs comprise more than 50 percent of the overall biotherapeutic market, a market that is continuing to grow.
Most large pharmaceutical biopharmaceutical companies are generating candidate antibodies for 10-20 targets per year. As small to mid-sized biotechs and academic drug discovery centers likely add 50-100% to this volume, the estimated global industrial needs for therapeutic antibody generation is in the neighborhood of 300-800 projects per year.
[High-throughput monoclonal antibody library screening has never been faster]
Despite this progression, the fact remains that determining which mAbs do the best job of slinging that hammer is still a rather tedious process. Production of high-quality, functional antibodies remains a major challenge. Over the past 25 years, Phage Display has been the favored way of amassing large amounts of antibodies. The technology is based on the fact that phage phenotype and genotype are physically linked. The phage display technique allows the creation of human libraries which contain up to 1010 different variants. (A variety of immunoglobulin gene sources including blood lymphocytes, bone marrow, and spleen are used for library construction).
The libraries need to be diverse enough in order to achieve a successful outcome and identify the best antibodies for targeted therapies. Historically, libraries were designed to maximize diversity but this came at the expense of non-specific binding and significantly increased pressure on chemistry, manufacturing and control (CMC) activities necessary to successfully advance new monoclonal antibody products from discovery to first-in-human trials and the market as quickly and economically as possible.
As a next-generation approach, Distributed Bio (DBio), a California company whose self-described mission is to "define a new paradigm in revolutionary bioengineered medicines for the entire biotechnology industry" has developed antibody discovery and engineering platforms that maximize structural diversity within the boundaries of naturally occurring antibody sequence landscapes. By joining an advanced computationally optimized human antibody library for antibody discovery (called SuperHuman) with a separate library that provides years of camelid repertoire analysis to inform a computationally optimized synthetic single domain library (called Tungsten) the technologies are able to offer pharmaceutical/biotech companies a differentiated and potentially robust solution that addresses maximum diversity (billions of antibodies) while avoiding known liabilities such as immunogenicity, thermostability and aggregation potential.
[Check it Out: Changing the Way Therapeutic Antibodies are Discovered.]
The efficiency of this system can't be underscored enough. The library contains roughly 76 billion unique antibodies, many orders of magnitude larger than the human naïve antibody repertoire, which should contain enough diversity to yield useful, high affinity hits across a broad range of target classes. At the same time, through a range of design strategies, DBio engineers have avoided inclusion of sequences that could promote CMC liabilities. The single-pass multi-parameter optimization, easy affinity maturation and cross-species optimization means a speedier process all-around. Importantly, are also capable of producing scFv for use in cell therapy and bispecific modalities alongside standard IgG paradigms.
Just think what the power of those hammers would be.
Charles River recently announced an exclusive partnership with Distributed Bio that provides clients access to Distributed Bio's antibody libraries and integrated antibody optimization technologies. The partnership integrates a next-generation antibody library platform in Charles River's biology, PK, pharmacology, biologics and safety services.
The New Era of CNS Discovery
Nov 05, 2020 |
Abandon the Amyloid Hypothesis? Not So Fast
Nancy A. Gillett
Rare Diseases, Common Challenges
Repurposing Drugs for Inflammatory Diseases
Fraser McIntosh
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Why was she still going on about routine, eating patterns and how much I was sleeping?
Why did it matter to her so much when I was struggling so much with flashbacks, nightmares and overwhelming pain?
Couldn't we just get on with talking about the important stuff?
I was broken. Suffering from a severe depressive episode and PTSD for the first time in my life, my world had shattered into billions of pieces. I needed her to rebuild me. Not go on session after session about life's basic needs.
Eighteen months on, at a positive stage of recovery, I get it. I understand her obsession with routine, eating and sleeping. I understand why she insisted, session after session, that I got that right before she was willing to make me face any of my traumas. I also want to shout about it to the outside world. Now I fully recognize that meeting my most basic needs is fundamental to my mental wellness. And I'm wondering if you do too.
Image source: Joshua Seong, Verywell, 2018.
As a teacher, I've often discussed Maslow's Hierarchy of Needs (see image above). It's fundamental to our role as effective educators to understand that students whose basic needs are not being met, aren't going to learn well.
However, it wasn't until I began to emerge out of that deep pit of dealing with depression and PTSD, that I started to understand how important it is for us all.
Look carefully at the bottom section of the pyramid. Food, sleep and breathing are clear physiological needs. They must be fulfilled in order to be physically well. Yet, what I have come to realize and accept is that actually if those needs aren't met, the impact on mental health can also be phenomenal.
My mental illness first began to emerge through nightmares. Actually, nightmare is too tame a word. Night terrors. They haunted me, for months on end. During the night, I re-lived traumas that I thought were long buried. I shouted, trembled and cried in my sleep. One night, I leapt out of bed so violently that I collided with a wardrobe and exhibited a black eye for days afterwards.
By day, I shook them off. Continued to work. And convinced myself that they weren't having an effect on me. Yet I was ignoring one of life's most basic needs: the fundamental requirement of sleep.
This lack of sleep was the first element that sent me on the downward spiral to a complete breakdown. Weary, my coping mechanisms disintegrated. Exhausted, my thoughts became irrational. Shattered, my ability to find the positive in any element of life, totally disintegrated.
I chuckle now at my ignorance and gall. How could I have questioned my therapist's insistence on finding strategies to help me sleep better?!
Lack of sleep and my spiraling mood, had a direct impact on my appetite. It was simple really. I didn't have one. Food no longer interested me. It wasn't that I didn't like anything. It was more that it didn't occur to me to eat.
At the time, I couldn't appreciate the significance of this. My therapist's suggestion that I set an alarm to remind me to have lunch when I was alone seemed excessive. It was no big deal. I missed the odd meal. It wouldn't do me any harm.
Yet it wasn't the odd meal. It became most meals. When I was alone, I didn't think about eating. When I was with my family, the kitchen noise and chaos was too much for me to bear and I sloped off to bed. Within a six weeks, I'd lost seven kilos and weight was still falling off me.
I was so much weaker, lacking the basic energy to function, to make any effort at all. It wasn't only physical energy that I struggled with. Even the energy to think…to begin a line of thought and to reach the end of it…became impossible.
Again, I look back and I'm startled by my ignorance. 'Why does it matter what I've eaten' were the words I wanted to yell at my therapist as she insisted on knowing about my eating patterns; and made suggestions about how I could improve them. Surely my night terrors, my fears and my pain were far more important than that? How wrong I was!
Suffering from PTSD has involved intense moments of panic. Moments in which my breathing becomes irregular and my chest becomes tight. It's a sensation that has often been compared by others to having an elephant sitting on your chest. And that image works well for me. It feels just like that.
Yet I was still skeptical when a mindfulness coach I was working with, emphasized over and over again the importance of breathing. Surely that's just a natural process we all get right without thinking about it, I thought. How on earth can thinking about my breathing change the way I feel about things?
But she planted a seed. And as she repeated it every week, I slowly began to think that maybe this focus on breathing wasn't so daft after all.
Unexpectedly, a friend then sent me a hypnotherapy recording to help me sleep at night. By this point, I'd moved on from night terrors but often found it hard to relax before going to sleep and still dreamed vividly. Believing in this friend, I followed the instructions diligently; even though I struggled to understand how it would make much difference. Breathe in deeply, hold it, breathe out slowly and release the day's stress. Repeat. Do that a few times and then take some random journey down some steps, counting even more slowly from twenty to zero as you go.
Unconvinced (and secretly a bit cynical), I decided I'd try for three nights before giving up. Yet only one night was needed. I began the breathing, then I walked deliberately and slowly down each step, and my head became a bit hazy… and then…well, then it was morning. What? It was morning?
I woke up feeling rested. I hadn't battled my thoughts before falling sleep. I hadn't had vivid dreams. I'd simply drifted off to sleep, without even realizing it.
So, what did I learn from all of this? Well, number one, was that my therapist was absolutely right (that's been the slightly annoying reality I've often had to accept). Much as I was desperate to face the traumas and pain I had experienced, so that I could just get over them and move on very quickly, I couldn't do that until my basic needs were being met.
You see, once I was sleeping properly, eating well and yes, able to breathe, then, and only then, was I in a fit space to face and deal with the issues I was struggling with. Eighteen months on, I am so much stronger than I was and, the minute I feel I am struggling again, I assess if I am meeting those basic needs. Invariably, I realise that sleep hasn't been the priority it should be or that I've been eating the wrong things. So, I take a step back from the busy world I am once again a part of and make sure I redress the balance.
My advice to you? Next time you are struggling mentally*, take a look at Maslow's Hierarchy of Needs. It's faced a fair amount of criticism in its time. But I suggest to you that if you focus on the physiological needs it shows in the first level of the pyramid, then you will be more prepared to confront any mental health difficulties you might experience.
Give it a go. It worked for me. It might just work for you too.
* I must stress that although this is important for everyone, I am not in any way suggesting that it will resolve mental illnesses. Looking after our basic needs is vital, but so too are talking therapies and medication for so many people who are battling mental illnesses. This is a vital piece in a puzzle but it is certainly not the only one.
This entry was posted in Depression and tagged Body, Breathing, Choices, Depression, Empowerment, Healing, Health, Mental Health, Mind, Self love, Sleep, Support, Wellbeing.
thanks for this- I needed a reminder!
Hi! What is the hypnotherapy recording you used? Thanks!
The recording was given to me by a friend but they aren't available to the public. Sorry!


Contents > Author > Jimmy Carter > Inaugural Address, 1977 1924- Pres.
for all he has done to heal our land.
adjust to changing times and still hold to unchanging principles."
only a people can provide it.
excited the founders of this Nation still awaits its consummation.
faith in the old dream.
can help to minimize my mistakes.
can be better. We can be even stronger than before.
united. In those times no prize was beyond our grasp.
must at the same time be both competent and compassionate.
and we are now struggling to enhance equality of opportunity.
persecute the weak, and human dignity must be enhanced.
We have learned that "more" is not necessarily "better,"
we can neither answer all questions nor solve all problems.
Our Nation can be strong abroad only if it is strong at home.
our Nation earns is essential to our strength.
of their own physical condition, but for basic human rights.
to help shape a just and peaceful world that is truly humane.
for success can mean life instead of death.
international policies which reflect our own most precious values.


In late 2008, the financial crisis terminated my 25-year mortgage career and my Inc. 500 company.
I lost everything and was forced to reinvent myself. I began a 5-year journey of rebuilding. Some of my original skills were useful; others I had to develop. I had to take new risks and most of all I had to focus on a path that would support my passion with a good business model. The journey has not always been easy, but I have had many successes and it has been fulfilling in many ways.
This week I enter a big new phase of that journey. I get to use my writing, theatre and producing skills in my new role as Executive Producer and sidekick for Amilya! on 77WABC, Talk Radio, New York. Every week I am now responsible for writing, producing and delivering on air, highly entertaining audio and digital content that will give listeners the Awesome Experience. It's a very rewarding opportunity.
Many people struggle with reinvention whether they are making a small change or really overhauling their life like I did. The thing about reinvention though, is that you get a mulligan, a do-over. You get to start again with a clean slate--only this time with more wisdom. Wouldn't it be great to do things the way that will make you most successful?
That's why it's no coincidence that I brought on Inc. columnist Lewis Schiff, author of Business Brilliant: Surprising Lessons From the Greatest Self-Made Business Icons, as Amilya's very first guest. Schiff studied hundreds of self-made success stories in great detail. Below are the things his subjects did differently to get to the top of the pack. Even if you are not reinventing, these tips from his observations will still help you achieve more success. And if like me, reinvention was thrust upon you, use them to make this reinvention your last.
As my grandmother used to say: "I've been rich and poor, and while there's no shame in being poor, I'd rather be rich." When I first started out, I only followed my passion. Much of my early success was by accident. This time I have been highly focused on activities that lead to wealth and stability. There are lots of good ideas, but great success comes from a well-developed, sustainable business model. Everything else is a waste of time and resources.
There is no sense in trying to reinvent the wheel if you don't have to. In my case, my industry and investors were decimated. I couldn't have done the same business even if I wanted to. But I was able to take the skills and resources I already had to rebuild in a new-but-related direction, which saved me years of exploration and failure.
You are going to fail. It's hard after a massive failure like mine to get over the embarrassment and talk about it. But I did. In fact I shared my failures with my friends and advisors so often even I got tired of hearing about them. (I have very patient friends and advisors.) But all that sharing helped me to analyze and learn from those failures and learn a new and better path. Now I celebrate my failures. I mitigate my risk so I can experiment often and fail safely. This is a big factor in fast reinvention.
When you're reinventing, your network is never big enough. In my case, few in my existing network had the connections and resources to help me. And they didn't know me as a marketer or writer, only as a mortgage and construction guy. Meeting new, dynamic people is part of your rebranding process. You need to strive for bigger, more powerful networks that fit your new business model. As Schiff says, you want to "Know people who know people." And don't hide who you used to be. Be willing to share with others about your past experiences. As my success grows from the ashes of my 2008 failure, I continue to receive more support and respect than if I had been consistently successful from the start. Wear your reinvention as a badge of courage and fortitude.
The year my business collapsed followed one of the best years I ever had. I was I thought in a safe and prosperous place. I was not in growth and opportunity mode; at 44, I was happily cruising. Since losing everything I have been a fierce opportunity generator. I never wait for things to just happen. I learn and inquire, and hunt for opportunities. I also filter them carefully and give them proper energy and weight so they don't distract from my path for success. Capitalizing on opportunities comes from knowledgeable recognition, not chasing bright, shiny objects.
I wouldn't wish my 2008 drama on any other entrepreneur, but looking back it's gratifying to be achieving at a whole new level in a field that fits so well. The lessons were valuable. I think many of you can get those without the hardship if you watch and learn or just read Schiff's book.
Like this post? If so, sign up here and never miss out on Kevin's thoughts and humor. And to hear Lewis and Kevin on the Amilya! Show, click here.


text:
Q: Webkit and SVG filter support I'm trying to get a complex SVG filter to produce results in Webkit. The filter is quite crowded as you will see below, but it renders a nice fractal-generated map, and does it well in Mozilla. I'd like to get Webkit to do the same.
The Wikipedia page on browser support for SVG says that Webkit supports SVG filters on nightly builds, but doesn't say how much it supports on the shipping version. I know filters behave somehow differently on every implementation.
What I'd like to know is;

*

*Is there something I'm missing here in order to get Webkit to render this properly?

*If #1 is no, then is there anything like a JavaScript library or similar that will make Webkit render the filter properly?

Update
I found out that Webkit needs a flag to enable SVG filters. Is there a way to switch this on in Safari and Chrome? Can it be done through some meta tag or javascript?
The filter
  <filter id="elevation" filterUnits="objectBoundingBox" x="0%" y="0%" width="100%" height="100%">
    <feFlood flood-color="black" result="bg"/>
    <feTurbulence type="turbulence" seed="68" stitchTiles="noStitch" numOctaves="8" baseFrequency="0.0025" result="turbulence"/>
    <feBlend in="bg" in2="turbulence" mode="screen"/>
    <feColorMatrix type="saturate" values="0"/>
    <feComponentTransfer>
        <feFuncR type="linear" slope="1.5" intercept=".3"/>
        <feFuncG type="linear" slope="1.5" intercept=".3"/>
        <feFuncB type="linear" slope="1.5" intercept=".3"/>
        <feFuncA type="identity" />
    </feComponentTransfer>
    <feColorMatrix type="matrix"
      values="1 0 0 0 0  0 1 0 0 0  0 0 1 0 0  0.2125 0.7154 0.0721 0 0"/>
    <feGaussianBlur stdDeviation="10" result="height"/>
    <feComponentTransfer result="contour">
        <feFuncR type="discrete" tableValues=" 0  0 .3 .4 .6 .8  1 1"/>
        <feFuncG type="discrete" tableValues=".1 .2 .2 .3 .5 .7 .9 1"/>
        <feFuncB type="discrete" tableValues=".3 .4 .1 .2 .4 .6 .8 1"/>
        <feFuncA type="discrete" tableValues=" 1  1  1  1  1  1  1 1"/>
    </feComponentTransfer>
    <feDiffuseLighting surfaceScale="100" diffuseConstant="1" in="height" result="sun" lighting-color="#FFC">
        <feDistantLight azimuth="-45" elevation="45"/>
    </feDiffuseLighting>
    <feDiffuseLighting surfaceScale="100" diffuseConstant="1" in="height" result="sky" lighting-color="#339">
        <feDistantLight azimuth="-135" elevation="70"/>
    </feDiffuseLighting>
    <feBlend in="sun" in2="sky" mode="screen" result="relief"/>
    <feBlend in="contour" in2="relief" mode="multiply"/>
  </filter>

A: Regarding SVG support, this page has a nice overview of what the browser do and don't:
http://www.codedread.com/svg-support.php (click on the image to get detailed results)
It basically triggers all the W3C SVG Tests in each browser. You can use these tests to see which filters are supported in your browser and have a look at the SVG code.
In our product we have a GaussianBlur for some years now working well in Firefox, but never in Safari. Google Chrome since version 6 might be better.

A: Looks like both Chrome and Safari are now using a version of Webkit that can render this filter.


text:
Libro honours 2016 Student Award recipients
Libro Credit Union honours 2016 Student Award recipients
LONDON, ON – Libro Credit Union today announced that a total of $60,000 has been awarded through Libro's Student Award Program to 20 passionate student leaders across southwestern Ontario, to support building prosperity in local communities.
Libro is honouring each of the 20 youth with a $3,000 award for demonstrating outstanding leadership, commitment and service in their local communities through volunteerism while balancing an outstanding level of academic performance. Since 2012, Libro has awarded more than $245,000 to 104 students, between the ages of 17 and 25, through its Student Award Program.
"These young leaders are stellar examples of the positive impact youth have in our communities across southwestern Ontario," said Tania Goodine, Executive Vice President Engagement at Libro Credit Union. "With their passion and drive, these students will influence the future prosperity of our region and we are very proud of their accomplishments."
The 2016 Student Award recipients are:
Recipients Location
Cole Anderson Sarnia
Danielle Bushey Chatham
Dennis Catt St. Thomas
Julian Donovan London
Kaitlin Endres London
Justin Garabon Harrow
Anna Healey Guelph
Flora Jung London
Taylor Lambert Petersburg
Michelle Liang LaSalle
Ghadeir Madlol London
Harry Orbach Miller London
Jake Poirier York
Madison Ryken London
Rachna Sharma London
Maddie Shiell St. Thomas
Jessica Snyder Harrow
Hayley Voort Stratford
Eileen Woolley Caledonia
Nicole Worozbyt London
Cole Anderson, recipient from Sarnia, is a Student Advisor on the Bluewater Health Community Advisory Council where he advises the senior executive team on the main healthcare concerns of students and youth in the community. Cole is also an active leader within the Lambton Kent District School Board as a Student Senator and Student Trustee, and coaches youth soccer and wrestling. "I seek out leadership opportunities that allow me to give back to my community," Anderson said. "One of my main priorities is to be a strong representative of the needs of youth in this community that has supported my success over the years as a student."
The 2016 recipients collectively logged over 11,000 hours of volunteering in their communities, impacting more than 80 organizations. Learn more about the 2016 Student Award recipients.
About Libro Credit Union
Libro is Ontario's third largest credit union with $4 billion in assets under administration and more than 103,000 Owners across southwestern Ontario and has been recognized as a 2016 & 2017 Platinum Level Aon Best Employer in Canada. As a co-operative financial institution with more than 70 years of history, Libro supports the well-being of people, businesses and communities by providing high-quality financial coaching and profit sharing. Libro is proud to support The Prosperity Project, which aims to grow prosperity in southwestern Ontario by mobilizing and inspiring collaboration, strengthening the financial health of people, families and businesses, and investing in our communities to help the region prosper together. Libro offers a full range of financial products and services for consumers, businesses and farms, including savings and chequing, investing, and borrowing. Great service can be experienced through 31 branches, online, telephone, mobile devices and a network of 4,000 ATMs across Canada.
For further information or to set-up an interview, please contact:
Mike Donachie, Communications Manager
Libro Credit Union
P: 519-672-0130 ext. 4344
Mike.Donachie@libro.ca
Introducing Libro | Downloads


text:
Nokia Announces Lumia 610 to Receive Firmware Upgrade Soon
| Updated: Tuesday, March 26, 2013, 19:26 [IST]
Microsoft has already started sending invites to the tech media world for a special event on October 29 in order to officially release the Windows Phone 8 OS.
Since the announcement of the latest incarnation of the Windows Phone platform, there is much anticipation among the tech enthusiasts regarding the next generation smartphones that will run on the OS and also about its new features.
In the meantime, Lumia 610 – the cheapest Windows Phone based handset, which was unveiled in February during the Mobile World Congress 2012 and released in India in July has managed to appear in the news as Nokia has rolled out a firmware update for the same.
Speaking of update, don't get confused thinking that it is the Windows Phone 7.8 update that will be rolled out to the existing Windows Phone 7 based handsets. This new update will deliver improved system performance, camera performance and usability.
The update will be rolled out to different countries at different times, owners of Lumia 610 will have to look out for a notification message on their smartphones for the availability of the software update, which can be installed using the Microsoft Zune software.
Speaking about the basic specifications, the Lumia 610 sports a 3.7 inch capacitive touchscreen display with a resolution of 480 x 800 pixels. It has a 5 MP camera, 8 GB internal storage and 256 MB RAM. The handset runs on Windows Phone 7.5 OS and is equipped with an 800MHz ARM Cortex A5 processor and a 1,300 mAh BP-3L battery offering 9.5 hours talk time and 720 hours standby.
Priced at Rs 12,999, the handset is pre-loaded with Nokia apps like Music, Maps and Drive. It comes in four different color options like Cyan, Magenta, Black and White.
Huawei P40 Pro Leaked Real-Life Images Confirm Dual Punch-Hole Display
Noida Woman Loses Rs. 1.5 Lakh Via Credit Card Fraud
Realme 6i Gets NBTC Certification: Specifications Still Under Wraps
Oppo Reno 3 Pro With Dual 44MP Selfie Camera To Arrive In India Soon
Read More About: smartphones updates windows phones lumia phones


text:
Q: event parameter and its purpose Hey everyone today i have a question about the event parameter. might sound a bit noobish but there are a few things i would like clarified for myself.
1.) does the (event) parameter or (e) have a default value? as in does javascript already define this within its programming.
2.) if so, in the case of this code snippet from jquery.com, does javascript understand the event that the anchor tag performs and thats where the .preventDefault comes into play.
3.) i ask this obviously to understand but im pretty sure javascript does have some predefined parameters. if not then i think i answer my own question that it is just defined by the value the parameter is given.
thank you for your help
<!doctype html>

  <meta charset="utf-8">
  <title>event.preventDefault demo</title>

default click action is prevented

A:
in the case of this code snippet from jQuery.com, does JavaScript understand the event that the anchor tag performs and that's where the .preventDefault comes into play.

It's worthwhile to first clarify that the anchor tag alone does not perform an event. The anchor tag is just markup that encodes particular uses/functions... mainly, the ability to let the user navigate to a different URL (as specified by the tag's href attribute). Rather, it's you (i.e., the user) that performs the event. The browser only knows to redirect you to that anchor tag's URL when you click on it.
The important point to take away is that certain actions/events on certain elements have default behaviours encoded into them. They are the default behaviors. For example:

*

*a click on an anchor tag (i.e., a link) navigates you to another address

*a click on input elements of either the checkbox or radio types checks the checkbox or filles the radio button, respectively

*a right-click on many elements brings up a context menu

*pressing 'enter' on a form field submits it to the server

So, yes, your question points to the right idea. JavaScript understands to disable those default behaviors (that is, to prevent the default actions) that are ordinarily executed for certain events on certain elements.