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Takeda Receives Positive CHMP Opinion for Maribavir for the Treatment of Adults with Post-transplant Cytomegalovirus (CMV) Refractory (With or Without Resistance) to Prior Therapies
− If Approved, Maribavir Would be the First and Only Inhibitor of CMV-specific UL97 Protein Kinase in the EU for Treatment of Adults with Post-transplant CMV Refractory (With or Without Resistance) to Prior Therapies1
− Positive Opinion Based on Phase 3 SOLSTICE Study Demonstrating Maribavir Was Statistically Superior to Conventional Therapies at Study Week 8, for Primary Endpoint2
− CMV is One of the Most Common and Serious Post-transplant Infections and Can Lead to Loss of Transplanted Organ and Failure of Graft 3,4
September 16, 2022 08:00 AM Eastern Daylight Time
OSAKA, Japan & CAMBRIDGE, Mass.--(BUSINESS WIRE)--Takeda (TSE:4502/NYSE:TAK) today announced the European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (CHMP) has recommended the approval of maribavir for the treatment of cytomegalovirus (CMV) infection and/or disease that are refractory (with or without resistance) to one or more prior therapies, including ganciclovir, valganciclovir, cidofovir or foscarnet in adult patients who have undergone a hematopoietic stem cell transplant (HSCT) or solid organ transplant (SOT).
The European Commission (EC) will consider the CHMP positive opinion and decide upon potential marketing authorization in the coming months. If approved, maribavir would be the first inhibitor of CMV-specific UL97 protein kinase in the European Union (EU) for this indication.1 The positive opinion from the CHMP was based on the SOLSTICE trial, which evaluated the safety and efficacy of maribavir versus conventional antiviral therapies—ganciclovir, valganciclovir, foscarnet or cidofovir—for the treatment of patients with CMV infection refractory, with or without resistance.
"Post-transplant care is critical for transplant recipients, and CMV infection can jeopardize successful outcomes for patients," said Daniel Curran, Head, Rare Diseases Therapeutic Area, Takeda. "The CHMP positive opinion on the marketing authorization of maribavir is a positive step toward redefining the CMV treatment landscape for transplant patients and their healthcare providers across Europe and toward addressing a great unmet need for this community."
CMV is one of the most common infections experienced by transplant patients, with a global estimated incidence rate of 16%–56% in SOT recipients and 30%–70% in HSCT recipients.5,6 More than 34,000 SOTs 7 and more than 48,000 HSCTs 8 were performed in Europe and neighboring countries in 2019.
About CMV
CMV is a beta herpesvirus that commonly infects humans; serologic evidence of prior infection can be found in 40%-100% of various adult populations.9 CMV typically resides latent and asymptomatic in the body but may reactivate during periods of immunosuppression. Serious disease may occur in individuals with compromised immune systems, which includes patients who receive immunosuppressants associated with various types of transplants including HSCT or SOT.5 Out of the estimated 200,000 adult transplants per year globally, CMV is one of the most common viral infections experienced by transplant recipients, with an estimated incidence rate between 16-56% in SOT recipients and 30-70% in HSCT recipients.5,6
In transplant recipients, reactivation of CMV can lead to serious consequences including loss of the transplanted organ and, in extreme cases, can be fatal.3,4 Existing therapies to treat post-transplant CMV infections may demonstrate serious side effects that require dose adjustments or may fail to adequately suppress viral replication.10 Additionally, existing therapies may require or prolong hospitalization due to administration.10,11
About Maribavir
Maribavir, an orally bioavailable anti-CMV compound, is the first and only antiviral agent that targets and inhibits the pUL97 protein kinase and its natural substrates.1
In November 2021, maribavir received U.S. Food and Drug Administration (FDA) approval, under the brand name LIVTENCITYTM, for the treatment of adults and pediatric patients (12 years of age or older and weighing at least 35 kg) with post-transplant cytomegalovirus (CMV) infection/disease that is refractory to treatment (with or without genotypic resistance) with ganciclovir, valganciclovir, cidofovir, or foscarnet. In addition to awaiting a final European Commission decision, regulatory filings are underway with other health authorities worldwide.
About Takeda's SOLSTICE Trial
The TAK-620-303 (SOLSTICE) trial (NCT02931539, EudraCT 2015-004725-13) was a global, multicenter, randomized, open-label, active-controlled superiority trial to assess the efficacy and safety of treatment with either maribavir or conventional antiviral therapy in 352 hematopoietic stem cell transplant and solid organ transplant recipients with CMV infection refractory, with or without resistance, to one or a combination of the conventional antiviral therapies: ganciclovir, valganciclovir, foscarnet or cidofovir. Adult patients underwent a 2-week screening period, followed by randomization 2:1 to maribavir (n=235) (400 mg, twice daily) or conventional antiviral therapies (n=117) (as dosed by the investigator) for up to 8-weeks. After completion of the treatment period, subjects entered a 12-week follow-up phase.2
The trial's primary efficacy endpoint was confirmed CMV DNA level <LLOQ (lower limit of quantification, [i.e. <137 IU/mL] in 2 consecutive samples separated by at least 5 days as assessed by COBAS® AmpliPrep/COBAS® TaqMan® CMV test) at the end of Week 8. The key secondary endpoint was CMV DNA level <LLOQ and CMV infection symptom control* at the end of Study Week 8 with maintenance of this treatment effect through Study Week 16.2
About Takeda
Takeda is a global, values-based, R&D-driven biopharmaceutical leader headquartered in Japan, committed to discover and deliver life-transforming treatments, guided by our commitment to patients, our people and the planet. Takeda focuses its R&D efforts on four therapeutic areas: Oncology, Rare Genetics and Hematology, Neuroscience, and Gastroenterology (GI). We also make targeted R&D investments in Plasma-Derived Therapies and Vaccines. We are focusing on developing highly innovative medicines that contribute to making a difference in people's lives by advancing the frontier of new treatment options and leveraging our enhanced collaborative R&D engine and capabilities to create a robust, modality-diverse pipeline. Our employees are committed to improving quality of life for patients and to working with our partners in health care in approximately 80 countries and regions. For more information, visit https://www.takeda.com.
For the purposes of this notice, "press release" means this document, any oral presentation, any question and answer session and any written or oral material discussed or distributed by Takeda Pharmaceutical Company Limited ("Takeda") regarding this release. This press release (including any oral briefing and any question-and-answer in connection with it) is not intended to, and does not constitute, represent or form part of any offer, invitation or solicitation of any offer to purchase, otherwise acquire, subscribe for, exchange, sell or otherwise dispose of, any securities or the solicitation of any vote or approval in any jurisdiction. No shares or other securities are being offered to the public by means of this press release. No offering of securities shall be made in the United States except pursuant to registration under the U.S. Securities Act of 1933, as amended, or an exemption therefrom. This press release is being given (together with any further information which may be provided to the recipient) on the condition that it is for use by the recipient for information purposes only (and not for the evaluation of any investment, acquisition, disposal or any other transaction). Any failure to comply with these restrictions may constitute a violation of applicable securities laws. The companies in which Takeda directly and indirectly owns investments are separate entities. In this press release, "Takeda" is sometimes used for convenience where references are made to Takeda and its subsidiaries in general. Likewise, the words "we", "us" and "our" are also used to refer to subsidiaries in general or to those who work for them. These expressions are also used where no useful purpose is served by identifying the particular company or companies.
This press release and any materials distributed in connection with this press release may contain forward-looking statements, beliefs or opinions regarding Takeda's future business, future position and results of operations, including estimates, forecasts, targets and plans for Takeda. Without limitation, forward-looking statements often include words such as "targets", "plans", "believes", "hopes", "continues", "expects", "aims", "intends", "ensures", "will", "may", "should", "would", "could" "anticipates", "estimates", "projects" or similar expressions or the negative thereof. These forward-looking statements are based on assumptions about many important factors, including the following, which could cause actual results to differ materially from those expressed or implied by the forward-looking statements: the economic circumstances surrounding Takeda's global business, including general economic conditions in Japan and the United States; competitive pressures and developments; changes to applicable laws and regulations, including global health care reforms; challenges inherent in new product development, including uncertainty of clinical success and decisions of regulatory authorities and the timing thereof; uncertainty of commercial success for new and existing products; manufacturing difficulties or delays; fluctuations in interest and currency exchange rates; claims or concerns regarding the safety or efficacy of marketed products or product candidates; the impact of health crises, like the novel coronavirus pandemic, on Takeda and its customers and suppliers, including foreign governments in countries in which Takeda operates, or on other facets of its business; the timing and impact of post-merger integration efforts with acquired companies; the ability to divest assets that are not core to Takeda's operations and the timing of any such divestment(s); and other factors identified in Takeda's most recent Annual Report on Form 20-F and Takeda's other reports filed with the U.S. Securities and Exchange Commission, available on Takeda's website at: https://www.takeda.com/investors/sec-filings/ or at www.sec.gov. Takeda does not undertake to update any of the forward-looking statements contained in this press release or any other forward-looking statements it may make, except as required by law or stock exchange rule. Past performance is not an indicator of future results and the results or statements of Takeda in this press release may not be indicative of, and are not an estimate, forecast, guarantee or projection of Takeda's future results.
This press release contains information about products that may not be available in all countries, or may be available under different trademarks, for different indications, in different dosages, or in different strengths. Nothing contained herein should be considered a solicitation, promotion or advertisement for any prescription drugs including the ones under development.
*CMV infection symptom control was defined as resolution or improvement of tissue-invasive disease or CMV syndrome for symptomatic patients at baseline, or no new symptoms for patients who were asymptomatic at baseline
1. Avram S, et al. Novel drug targets in 2021. Nature Reviews Drug Discovery. 2022;21(5):328-328.
2. Avery R, et al. Maribavir for refractory cytomegalovirus infections with or without resistance post-transplant: results from a phase 3 randomized clinical trial. Clinical Infectious Diseases. 2022;75(4): 690–701.
3. Ramanan P, Razonable RR. Cytomegalovirus infections in solid organ transplantation: a review. Infection & Chemotherapy. 2013;45(3):260.
4. Camargo JF, Komanduri KV. Emerging concepts in cytomegalovirus infection following hematopoietic stem cell transplantation. Hematology/Oncology and Stem Cell Therapy. 2017;10(4):233-238.
5. Azevedo L, et al. Cytomegalovirus infection in transplant recipients. Clinics. 2015;70(7):515-523.
6. Styczynski J. Who is the patient at risk of cmv recurrence: a review of the current scientific evidence with a focus on hematopoietic cell transplantation. Infect Dis Ther. 2018;7:1-16.
7. Vanholder, R, et al. Organ donation and transplantation: a multi-stakeholder call to action. Nature Reviews Nephrology. 2021;17:554-568.
8. Passweg JR, et al. Hematopoietic cell transplantation and cellular therapy survey of the EBMT: monitoring of activities and trends over 30 years. Bone Marrow Transplant. 2021;56(7):1651-1664.
9. de la Hoz R. Diagnosis and treatment approaches to CMV infections in adult patients. Journal of Clinical Virology. 2002;25:1-12.
10. Chemaly RF, et al. Definitions of resistant and refractory cytomegalovirus infection and disease in transplant recipients for use in clinical trials. Clinical Infectious Diseases. 2019;68(8):1420-1426.
11. Martín-Gandul C, et al. Clinical impact of neutropenia related with the preemptive therapy of CMV infection in solid organ transplant recipients. Journal of Infection. 2014;69(5):500-506.
Japanese Media
Jun Saito
jun.saito@takeda.com
Erin-Marie Beals
erin-marie.beals@takeda.com
Abhi Basu
abhi.basu@takeda.com


The many legislative changes made to try and make freeholders and leaseholders more equal has in fact made a complicated tenure even more complicated although it is fair to say that some of the rights granted to leaseholders have been used successfully. What hasn't changed is that freeholder still owns everything, i.e. the structure, roof, the land the building stands on, foundations, load bearing walls, gardens, landings, paths, gates, fences, drives, stairways, and any other outbuildings as well as anything inside the building such as plant rooms, lift motor rooms, and meter cupboards. These are defined as common areas. Leaseholders on the other hand still only own an 'interest' carved out of the dominant estate of freehold in the form of a lease, a document which acts as a contract to allowing leaseholders to live in the property for a pre-determined amount of years. So the tenancy of long leasehold still falls between that of being a freeholder and a renting tenant.
Covenants still lie at the heart of all leases, which are promises made by the parties to do certain things (positive), and not to do certain things (restrictive). For example, freeholders covenant to repair and maintain the common areas, and place buildings insurance. Leaseholders covenant to pay service charges to enable the freeholders to adhere to their own covenants and to pay ground rent (which is not exactly what it says on the tin). They also covenant not do certain things such as not to sublet without the consent of the freeholder, and not to alter the property without freeholder consent (to name just two) but how many covenants and what they are depend on how the lease is drawn. Covenants are either going to expressly written into the lease or implied and its important to be aware that the latter have just as much force in law as the former.
A lease of a new build property usually starts with a term of 99 or 125 years and each time the lease is sold, the unexpired term (how many years are left) reduces. Other leases in older buildings can be very short, with some having so few left that they are difficult to market due to the criteria demanded by lenders. Others are of a duration of 999 years (where leaseholders have exercised their right to group together to buy the freehold themselves) and other leases fall somewhere between the two due to another leaseholder right having been exercised, that of individual lease extensions.
The initial ground rent is usually £100 to £250 per annum in increments, the rent review frequency is 5 to 33 years with the most common rent review type being a fixed uplift, a regular rise according to the Retail Price Index which allows the rent to track inflation. Other types are the House Price Index or the percentage capital value of the property.
How many unexpired years are there remaining on the lease?
Can the lease be extended?
Have there been any breaches of the lease by the freeholder?
Have any lease breaches been remedied or are they still ongoing?
Does the lease allow the keeping of pets?
Does the lease allow you to use a car park or space and allow access to the gardens?
Are there any other conditions or restrictions in the lease which impacts on how the property is used?
Are there any defects in the lease relating to buildings insurance?
Are the buildings insurance payments up to date?
Are the interests of lessees and their mortgages automatically noted on the buildings insurance Policy?
What is the name and address of the freeholder?
Who are the freeholder's solicitors?
Is the freehold owner deemed a 'absentee landlord' i.e. are his whereabouts known?
Is the freeholder deemed 'absent' i.e. his whereabouts are unknown?
Has the Landlord ever served a Notice on the seller (or to their knowledge their predecessors in Title) in matters relating to the Lease or the use of the flat?
Is there a head lessee?
Is the flat 'share of the freehold'?
Is the company limited by guarantee?
Is the purchaser required to become a member of the company?
Note: If the propety has an absent freeholder it is less attractive to mortgage lenders. If they agree to lend but then have to reposses a mortgaged property the size of the market they can then sell to will be limited. This may result in the property having to be sold at auction and at a loss to the lender. It will also not be possible to exercise the right to buy the freehold during the conveyancing process because a premium needs to. be agreed with the freeholder.
On the other hand if a clear title can be provided (also known as a "clean title," "just title," "good title" and "free and clear title") which is a title without any kind of levy from creditors or other parties, they may lend as there is no question as to legal ownership.
Can a copy receipt be obtained from the landlord showing that the seller has paid the ground rent for the last three years?
Is the ground rent paid to the landlord separately to service charges paid to managing agents?
Is there an up to date health and safety risk assessment?
Is here an up to date fire risk assessment?
Is there a copy of the asbestos survey for the common parts?
What is the name and address of the managing agent?
What is the name of the resident management company (or a Right to Manage Company)?
Is the management company registered at Companies House and still in existence?
Where can the RMC (RTM) Memorandum and Articles be found?
Is the RMC limited by shares?
Has confirmation been obtained that the sellers share certificate will be handed over on completion along with a (signed) stock transfer form?
Does the lender need a copy of the company's Memorandum and Articles of Association?
What do service charge cover?
Are the service charges calculated on a percentage or a square footing?
Are there any interest charges and penalties for late payments?
Will there be a surplus or deficit in the service charge accounts after the financial year-end and are they transferred back across individual leaseholders?
Can the previous 3 years service charge accounts be provided?
Have any problems with the service charges been reported to the lender?
Is there a sinking fund to cover large items of expenditure that come as the building ages?
Are sinking fund payments up to date?
Are reserve fund payments up to date?
If a sinking/reserve fund is held, how much is being held for this particular property?
Is a receipt for rent and service charges required by the lender following completion?
What happens if confirmation of ground rent and service charge receipts cannot be obtained, such as when the freeholder is absent?
Are there any service charge collection dates?
Does it enable the fees of a managing agent to be an allowable service charge expenditure item?
Are there provisions for a reserve fund which is designed to even out normal day to day service charge expenditure?
Are there provisons for a sinking fund to cover large areas of expected (or unexpected) expenditure that comes as the building ages?
Does the lease allow subletting?
Is the consent of the freeholder required?
Does the lease allow the subletting of the property to tenants on housing benefit?
Is there a sitting tenant?
Is the current mortgage a buy-to-let mortgage?
Does the lender need a counter-part or a certified copy of the tenancy agreement?
Whilst some elements of leasehold purchasing is the same as that of freehold, such as checking the property title, and carrying out local authority searches many prospective leaseholders still have no idea what they are purchasing and the long-term financial commitments they are making.
There have been periodic attempts to make the leasehold conveyancing process less complicated and since the introduction of prescribed lease clauses there have been two more leasehold forms created: LPE1 for use from 1st October 2015, which has questions asked on behalf of the buyer, and LPE2, the buyers leasehold information summary which was introduced in response to the Competitions and Market's Authority Market Study on Residential Property Management Services. This study looked to make clearer the ongoing financial obligations leasehold purchasers were committing to making. By that they meant service charges, buildings insurance, ground rent, administration charges and the freeholder granting consents such as subletting and altering the property.
We now have a new Freeholder Enquiries Form created by ARMA in March 2019 with questions to be asked on behalf of the buyer.
The appointed representative for any of the above.
I suppose the real questions are though, will any amount of forms make leasehold conveyancing any easier? Lease aren't the same from development to development and even today, they can be badly written and therefore defective. And what about the knowledge of conveyancing solicitors who are more than likely not very well versed in leasehold? Buyers of new build properties are being kept in the dark on key issues such having to pay for road maintenance and estate services in addition to paying their Council and many of them find their ground rents sold to parties without their knowledge. As a result their ground rents have raised to such a degree as to make their properties unsellable!
Leasehold tenure is now getting a lot of attention from campaign groups and the Government with Commonhold, a third way of purchasing property introduced in the Commonhold and a Leasehold Reform Act 2002 also being revisited (as it has yet to take off) but will consumers ever see the demise of leasehold, as has happened in other countries? Unlikely considering the all the vested interests!


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North Dublin Apartment Block
Source: The Journal.ie
North Dublin apartment block given green light despite objection from local pub
A FIVE STOREY apartment block development on Dublin's Northside has been given the green light by Dublin City Council after being previously rejected by An Bord Pleanála.
Permission for the apartment block at Cross Guns Bridge in Phibsborough was overturned last August after a local pub objected about the potential impact the development would have on its business.
Dublin City Council had originally granted roofing contractor P Rooney Roofing permission to build a five-storey development containing nine apartments, as well as a ground-floor café, last March but this was overturned by An Bord Pleanála after a number of locals objected.
They said that its height was excessive, that it would negatively impact wildlife, that it was out of character with the area and that it would overshadow and overlook other buildings.
The developer intended to provide pedestrian and vehicular access to the apartments via Phibsborough Road and a rear lane called McGuinness' Lane.
The laneway is situated between a snooker hall on Royal Canal Bank, a road adjacent to the Royal Canal, and back of The Bald Eagle pub on Phibsborough Road.
Cross Guns Snooker Hall and The Bald Eagle use the laneway for storing rubbish and the delivery of kegs, and while both businesses have access to it, P Rooney Roofing contended that it had right of way to use it.
In her report last year, planning inspector Sarah Lynch said that if a development had the potential for noise disturbance, it should include measures to reduce noise levels.
However, she noted that no such measures were submitted by the developer as part of its plans, saying this would be necessary to ensure that insulation was provided to ensure both the amenities of future residents and the economic viability of the Bald Eagle pub, which is adjacent to the site.
Lynch also found the development was contrary to the provisions of Dublin City Council's Development Plan.
Following An Bord Pleanála's rejection, the developer submitted revised plans in April.
Under these plans, Dublin City Council's Planning Department noted that there are no balconies, bedrooms, or living areas in immediate proximity to the pub's outdoor seating area, and the more noise-sensitive spaces are located to the north.
"Nonetheless, given the previous reason for refusal on the site, the applicant should be requested to specifically address the issue of noise from the pub outdoor seating area, and its potential impact on the apartments at the east end of the site," it said.
The Council also said that, given that the site is vacant, the reuse of land zoned for residential development in this case is "to be welcomed" and is in line with the Council's Development Plan.
An Bord Pleanála previously noted that a proposed ground floor bedroom window faced directly onto McGuinness' Lane.
Lynch said that this gave minimum potential for daylight to enter the room, and that the window would also open directly onto the McGuinness' Lane where rubbish was stored.
She said the use of the laneway was a legal matter and not one that the authority could determine, but found a number of planning issues relating to its location.
The Council, in granting permission for the revised plans, said the ground floor unit was elevated sufficiently above ground level and that the apartments had been redesigned to provide apartments to the north instead.
With reporting from Stephen McDermott
By admin|2020-07-06T12:13:18+00:00July 6th, 2020|News|0 Comments

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Navigating this site/Finding resources here
Honest and dishonest: a clarification
Honest History's history
Structure and committee
Editorial and moderation policy
Joint action policy
Choice Whizzbangs 2014-15
Centenary Watch
Register with Honest History
Australia's war history
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Inequality in Australia
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Finding resources here…
References by author: A-Z
Wilfred Burchett in Hiroshima: highlights reel
'Wilfred Burchett in Hiroshima: highlights reel', Honest History, 9 August 2015
Today is the 70th anniversary of the dropping of an atomic bomb on Nagasaki, Japan. By the end of 1945 up to 80 000 people in Nagasaki had died as a result of the bomb.
In this article, the distinguished Australian journalist, Wilfred Burchett, writes in the London Daily Express of the effects of the bomb dropped on Hiroshima on 6 August. (The Daily Express knew Burchett as 'Peter'.) The text of the article has been referred to us by Richard Tanter and we reprint it in full, first, because the story of Hiroshima and Nagasaki is as much part of Australia's war history as it is of Japan's and the world's and, secondly, because of Wilfred Burchett's status in Australian journalism.
Tanter himself wrote an article on Burchett and the Hiroshima story. There is more on Burchett's article and on Burchett, a controversial figure, from Amy and David Goodman, Robert Manne, Greg Mitchell, John Pilger and Bob Treasure. Honest History has a miscellany on Hiroshima-Nagasaki (and Lone Pine).
Update 4 September 2015: article from Burchett biographer Tom Heenan in The Conversation.
Daily Express (London) 5 September 1945
30th Day in Hiroshima: Those who escaped begin to die, victims of THE ATOMIC PLAGUE
'I Write this as a Warning to the World'
DOCTORS FALL AS THEY WORK
Poison gas fear: All wear masks
Express Staff Reporter Peter Burchett was the first Allied reporter to enter the atom-bomb city. He travelled 400 miles from Tokyo alone and unarmed, carrying rations for seven meals – food is almost unobtainable in Japan – a black umbrella, and a typewriter. Here is his story from – HIROSHIMA, Tuesday
In Hiroshima, 30 days after the first atomic bomb destroyed the city and shook the world, people are still dying, mysteriously and horribly – people who were uninjured by the cataclysm – from an unknown something which I can only describe as atomic plague.
Hiroshima does not look like a bombed city. It looks as if a monster steamroller had passed over it and squashed it out of existence. I write these facts as dispassionately as I can in the hope that they will act as a warning to the world.
In this first testing ground of the atomic bomb I have seen the most terrible and frightening desolation in four years of war. It makes a blitzed Pacific island seem like an Eden. The damage is far greater than photographs can show.
When you arrive in Hiroshima you can look around and for 25, perhaps 30, square miles you can hardly see a building. It gives you an empty feeling in the stomach to see such man-made devastation.
I picked my way to a shack used as a temporary police headquarters in the middle of the vanished city. Looking south from there I could see about three miles of reddish rubble. That is all the atomic bomb left of dozens of blocks of city streets, of buildings, homes, factories and human beings.
STILL THEY FALL
There is just nothing standing except about 20 factory chimneys ¬ chimneys with no factories. I looked west. A group of half a dozen gutted buildings. And then again nothing.
The police chief of Hiroshima welcomed me eagerly as the first Allied correspondent to reach the city. With the local manager of Domei, a leading Japanese news agency, he drove me through or, perhaps, I should say over, the city. And he took me to hospitals where the victims of the bomb are still being treated.
In these hospitals I found people who, when the bomb fell, suffered absolutely no injuries, but now are dying from the uncanny after-effects.
For no apparent reason their health began to fail. They lost appetite. Their hair fell out. Bluish spots appeared on their bodies. And the bleeding began from the ears, nose and mouth.
At first the doctors told me they thought these were the symptoms of general debility. They gave their patients Vitamin A injections. The results were horrible. The flesh started rotting away from the hole caused by the injection of the needle.
And in every case the victim died.
That is one of the after-effects of the first atomic bomb man ever dropped and I do not want to see any more examples of it. But in walking through the month-old rubble I found others.
THE SULPHUR SMELL
My nose detected a peculiar odour unlike anything I have ever smelled before. It is something like sulphur, but not quite. I could smell it when I passed a fire that was still smouldering, or at a spot where they were still recovering bodies from the wreckage. But I could also smell it where everything was still deserted.
They believe it is given off by the poisonous gas still issuing from the earth soaked with radioactivity released by the split uranium atom.
And so the people of Hiroshima today are walking through the forlorn desolation of their once proud city with gauze masks over their mouths and noses. It probably does not help them physically.
But it helps them mentally.
From the moment that this devastation was loosed upon Hiroshima the people who survived have hated the white man. It is a hate the intensity of which is almost as frightening as the bomb itself.
'ALL CLEAR' WENT
The counted dead number 53,000. Another 30,000 are missing, which means 'certainly dead'. In the day I have stayed in Hiroshima – and this is nearly a month after the bombing – 100 people have died from its effects.
They were some of the 13,000 seriously injured by the explosion. They have been dying at the rate of 100 a day. And they will probably all die. Another 40,000 were slightly injured.
Burchett, 1953 (CPA, The Guardian)
These casualties might not have been as high except for a tragic mistake. The authorities thought this was just another routine Super-Fort raid. The plane flew over the target and dropped the parachute which carried the bomb to its explosion point.
The American plane passed out of sight. The all-clear was sounded and the people of Hiroshima came out from their shelters. Almost a minute later the bomb reached the 2,000 foot altitude at which it was timed to explode – at the moment when nearly everyone in Hiroshima was in the streets.
Hundreds upon hundreds of the dead were so badly burned in the terrific heat generated by the bomb that it was not even possible to tell whether they were men or women, old or young.
Of thousands of others, nearer the centre of the explosion, there was no trace. They vanished. The theory in Hiroshima is that the atomic heat was so great that they burned instantly to ashes – except that there were no ashes.
If you could see what is left of Hiroshima you would think that London had not been touched by bombs.
HEAP OF RUBBLE
The Imperial Palace, once an imposing building, is a heap of rubble three feet high, and there is one piece of wall. Roof, floors and everything else is dust.
Hiroshima has one intact building – the Bank of Japan. This in a city which at the start of the war had a population of 310,000.
Almost every Japanese scientist has visited Hiroshima in the past three weeks to try to find a way of relieving the people's suffering. Now they themselves have become sufferers.
For the first fortnight after the bomb dropped they found they could not stay long in the fallen city. They had dizzy spells and headaches. Then minor insect bites developed into great swellings which would not heal. Their health steadily deteriorated.
Then they found another extraordinary effect of the new terror from the skies.
Many people had suffered only a slight cut from a falling splinter of brick or steel. They should have recovered quickly. But they did not.
They developed an acute sickness. Their gums began to bleed and then they vomited blood. And finally they died.
All these phenomena, they told me, were due to the radio-activity released by the atomic bomb's explosion of the uranium atom.
Hiroshima aftermath with autograph of Enola Gay pilot (Wikimedia Commons/US Navy Public Affairs/Jaybear)
WATER POISONED
They found that the water had been poisoned by chemical reaction. Even today every drop of water consumed in Hiroshima comes from other cities. The people of Hiroshima are still afraid.
The scientists told me they have noted a great difference between the effect of the bombs in Hiroshima and in Nagasaki.
Hiroshima is in perfectly flat delta country. Nagasaki is hilly. When the bomb dropped on Hiroshima the weather was bad, and a big rainstorm developed soon afterwards.
And so they believe that the uranium radiation was driven into the earth and that, because so many are still falling sick and dying, it is still the cause of this man-made plague.
At Nagasaki, on the other hand, the weather was perfect, and scientists believe that this allowed the radio-activity to dissipate into the atmosphere more rapidly. In addition, the force of the bomb explosion was, to a large extent, expended in the sea, where only fish were killed.
To support this theory, the scientists point to the fact that, in Nagasaki, death came swiftly, suddenly, and that there have been no after-effects such as those that Hiroshima is still suffering.
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Home Popular lifehacks Is Colt M4 an AR 15?
on 04/15/2021 04/15/2021 Popular lifehacks
Is Colt M4 an AR 15?
Mell
In reality, the M4 is the carbine version of the M16, the real military version of the AR-15. For one, the M4 is a carbine-length rifle, so it has a smaller, 14.5-inch barrel, but the standard AR-15 barrel is 16 inches.
Is Colt AR 15 good?
One of the longest running contractors to the U.S. military, Colt puts out some amazing rifles. The LE6920 is a competitively priced tactical rifle that is still in active service with many law enforcement units. The barrel length is ideal, and the iron sights work wonders.
Which AR 15 is most like an M4?
The AR-10 is a derivative of the civilian AR-15 rifle, which is functionally identical to the M4A1 — minus the ability to fire fully automatic. The AR-10 is slightly larger and heavier than the AR-15 and is chambered for the 7.62-millimeter round. The Army's version would be capable of fully automatic fire.
How much is a 22 ar worth?
AR 22 rifle PRICE AND HISTORICAL VALUE AN AR 22 rifle is currently worth an average price of $368.22 new and $310.31 used .
What rifle is replacing the M4?
While the M27 will replace the M4 as the standard-issue rifle for the Marine Corps infantry, non-infantry Marines will continue to field the M4 for the foreseeable future.
Is an AR 15 just a 22?
The cartridge on the left is the 5.56 NATO. Both are 22 caliber/diameter bullets, but that is where the similarity ends. Re: "Why is an AR 15 called an assault rifle when it fires a . 22 size (the smallest bullet on the market today) and no one in their right mind would go to war with it?"
Does tippmann make real guns?
The Tippmann family, headed by Dennis Tippmann Senior, originally manufactured collectible, half-scale replica machine guns. In 2010, Tippmann Sports acquired NXe, a manufacturer of soft goods for the paintball industry.
Is the colt m4.22 rimfire the same as the AR 15?
The Colt M4 Ops .22 rimfire AR-15 is a dead ringer for the real deal, and it is pretty close functionally as well. Not to dash hopes of bolting on an Colt M4 Ops .22 Rimfire upper onto your existing AR-15 lower, but the Colt M4 .22 rimfire AR-15 has proprietary internals and functions differently than an AR.
Can a Colt M4 Ops be used as an AR 15?
First, the Colt M4 Ops is a near perfect analog training stand-in for almost any standard carbine length AR-15 on the market from both a weight and configuration perspective.
Which is the best AR 15 for.22lr?
Best AR-15 in .22LR 1 Shooting the M4 .22 Carbine. This .22 long rifle has a design based on the original Colt M4. 2 Two models worthy of consideration. Let's take a look at two models that are currently for sale that will meet (and exceed!) the expectation of those looking for the best 3 Best .22LR Conversions and Uppers. …
Where is the bolt on a colt m4.22lr?
On the M4 .22 Carbine, you do not remove the bolt or anything but the charging handle. At the very top of the "bolt" is a hex bolt that allows you to adjust the bolt speed depending on the ammo you are using.
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The title of the topic is "International touristy processes and Georgia". From the topic we see the meaning of processes of globalisation and trans nationalization in tourism industry, which it is one of the main questions of the modern world.
The perspectives of tourism development in Ureki.
The work represents the perspectives of tourism development in the Black Sea unique resort Ureki. On the basis of treatment questionnaire by German firm `Goppa~ 200 holidaymakers and local inhabitants participated in the analysis of marketing questionnaire which is about social environment and future of resorts. In spite of obstacles of developing of resort Ureki some kind of advances seem to appear.
We reckon that marketing questionnaire and its result will support as the resort administration as private entrepreneurs. The marketing questionnaire and its results give the opportunity of marketing interesting conclusions.
People started to search the world in eighteenth century and are still thirsty for pleasure from knowledge and exotics. All this time women had been setting up their place in society. Now they are examining their opportunities and increasing their knowledge to help communities worldwide. As a result women's travel as a new trend of world tourism has been established.
In the current work such areas as possible reasons for women's travel, women-only services, advices for women to choose the tour correctly, packing for women adventure, travel safety are discussed. The main aspect of my issue is women's travel possible development in Georgia.
The goal of this work is to make people see how important and interesting could be one women-only trip outside the country and how can such new business affect our country.
Problems our Building Up the Territory of Krtsanisi Forest-Park and Its Buffer Zone.
2. Seychelles! Its very name seems to whisper of Paradise. And for most it is as close as they can get on earth. As your plane homes in on those tiny specks of land a thousand miles from anywhere in the glittering waters of the Indian Ocean – and thousands of miles from the strains and pressures of modern life – prepare to witness a miracle. There are deserted beaches of white sand washed by warm, clear seas, and shaded by leafy palms and kindly takamakas. All this in a country where there is no need to fear about your health, tropical diseases, or dodgy drinking water. As you might well expect of Paradise, Seychelles has none of these blights – not even malaria.
The paper is discussing problems on administrative and territorial jointing, of the cities of Tbilisi and Rustavi populations, ecological problems, and creation of a recreation complex between the two cities. The best solutions to be found for the above problems will require not only the area, but certain financial support as well i.e. solid investments to be provided both on the side of the State and private investors.
The Effect of the Tragic Event of September 11 on the Tourism of U.K.
The tragic events of September 11 effected tourism in every region of the world. U.K. is not exception. Britain's top four tour operators cut capacity about 15% before Christmas 2000 when bookings were down by 40%. Since then reservation for summer season has improved. U.K. market is starting to pick up again.
There are a lot of shortcomings in the process of tourism management in Georgia, which can be regulated by means of mutual concordance between the entrepreneurs, involved in the Government of the country and its tourism. It can be said, that the ways of tourism development in the country are in the hands of the Government, which is to solve the problems, such as perfection of legislative basis of tourism, reform of tax policy, training of staff in some extent as well, guarantee of stability etc, i.e. the environment, essential for tourism development is to be provided.
On the other hand, an entrepreneur must provide a world standard of its production, consider the experience of foreign firms and support training of specialists in the relevant field.
The development and caring out of optimal supervision programs in the hotel business, in competitive environment, is the one of the obligatory condition for the organizations that is included in this sphere. Receiving and processing the information about the new products, acceptable for public, and caring out the appropriate actions immediately, delivering appropriate high level products for all categories of people causes the success of organizations included in hotel industry and also makes their service attractive for people.
To obtain different types of information necessary for the preliminary analysis and market planing is essential for the manager in addition to the market research in tourism and hotel business.
Such a type of activity as tourism includes tour organization and hospitality industry. Market relations in the hospitality industry play an essential role particularly in the conditions of market economy.
Entertament occupies one of the important places in Tourizm Industry.
The aim of entertament industry is the creation of amusement conditions i.e. the complex of such conditions which an entertament procces is depended on.
This topic is about travel agencies of Georgia, about their work and connections. Most of them don't have full service, which mainly depends on existing requirements. Georgian travel agencies offer: ticket sales reservation, hotel booking, cargo service, travel insurance, conferences and meetings, visa support, leisure tours, business travels, study tours, adventure tours and others.
Sport and tourism are probably the two activities that have the greatest social and economic repercussion in the world today. "Sport-oriented" tourism is already a global industry. Georgian has a good location, nice climate and beautiful nature, so the country has great abilities for development of different kinds of "Sport-oriented" tourism.
In regards to history and architecture, Mtskheta is the most important treasures of Georgian culture.
It's lustrous historical and cultural monuments: Svetitskhoveli, Samtavro Monastery, Shiomgvime Monastery, Jvari and Armaztsikhe ere the main factors to make the tourists interested in the city. There are more visitors coming in the city than tourists because it doesn't need more than a day to see all the sights of the city.
We can say, that today Mtskheta can get not only visitors, but tourists too, as there are all the necessary objects for their accommodation in Mtskheta.
In future various faces of tourism will be developed in Mtskheta, as there are all the conditions for it, and this situation will be good for life of the city and another regions of Georgia.
One of the important results of social-economic crisis is more and more shortened tourism sphere.Its rehabilitation and development is the aim of the national conception of tourism. Orientation must be taken on national cultural, historical and natural value system and territory and they must be included in the life cycle of Georgian people.
According to the data of January 29, 2002, which was published on the web site of The World Tourism Organization (WTO) growing of tourism, has reduced. Compared to the 2000, the international arrivals slipped by 1,3%, be to the terrorist attacks of September 11 and the International Economical crisis.
The tragic events of September 11 affected tourism in every region of the world, but even before that there was a cooling in growth of outbound travel from countries like Germany, Japan and the USA.
International tourist arrivals totaled 689 million in 2001, compared to 697 million in 2000.
WTO estimates that in 2001, from January to August, arrivals worldwide grew by 3%, but the last four months of 2001 suffered a drop of 11%. Other events that had a negative impact on the tourism industry last year included the outbreak of foot and mouth disease in the United Kingdom, Ireland and the Netherlands, which resulted in drops of 5-6% during the first eight months of 2001; the Israeli-Palestinian conflict, and the economic crisis in Argentina, depressed travel in the Middle East and South America.
Kutaisi A. Tsereteli state University Law faculty.
In the given work the perspectives of development of tourist business security matters and regulation with the certain legislative basis are examined.
The problems connected to the professionalism of people working in the branch of truism are discussed in this theme, and practically and theoretically solve these ones. The main accent is transferred on the preference of students studding in high schools and finances to cut this question.
The term paper is dedicated to Italy and consists of several chapters. In chapter 1 the geographical location of Italy and its peculiarities, the mountains and bordering countries are described. The importance of geographical location of Italy for European trade and economy is emphasized. Chapter 2 is dedicated to the diversity of the nature of Italy. The diversity of natural features is of major importance for national agriculture, which is engaged in growing of great variety of fruit, cereals and vegetables. The seas enveloping Italy are rich in fish and other kinds of sea products, which is of vital importance for the population engaged in fishery. The treasures of soil ensure the functioning of National industry. The people of Italy, various national minorities, their languages, religion, traditions and cuisines as well as the Italian Diaspora abroad are described in chapter 3. Glimpses of Italian history, the political order of today's Italy, its government, the structure of legislative and executive authorities (parliament), political parties and associations are analyzed in chapter 4. The variety of historical monuments of Rome, Vatican, Florence and other famous cities, the worldwide known Coliseum, St. Peters Cathedral, the Church and monastery of San Marco with the masterpiece of the Last Supper of Dominick Girlandaio and the Synagogue of Florence, the famous La Scala and many other places of interest for tourists are reviewed in chapter 5. One of most interesting aspects of every country's life are the holidays and festivals. Italian carnivals and festivals, the way the Italians celebrate them all over the county are reviewed in chapter 6.
Austria is located in Central Europe. Border countries: Czech Republic, Germany, Hungary, Italy, Liechtenstein, Slovakia, Slovenia, and Switzerland. Climate temperate; continental, cloudy; cold winters with frequent rain in lowlands and snow in mountains; cool summers with occasional showers. Terrain in the west and south mostly mountains (Alps); along the eastern and northern margins mostly flat or gently sloping. Natural resources iron ore, oil, timber, magnetite, lead, coal, lignite, copper, and hydropower. Geography note landlocked; strategic location at the crossroads of central Europe with many easily traversable Alpine passes and valleys; major river I the Danube; population is concentrated on eastern lowlands. Population approximately 8 millions. Ethnic groups are German 98%, Creation, Slovene, Hungarians, Czechs, Slovaks, and Italians. Data code AU. Government is type federal republic. Capital Vienna. Administration divisions 9 states Borderland, Corinthian, Lower Austria, Upper Austria, Salzburg, Styria, Tytol, Vorarlberg and Vienna. Economy overview Austria with its well-developed market economy and high standard of living is closely tied to other EU economies, especially Germany's.
So Austria has a great cultural and historical heritage and that's why it is one of the most visited countries in Europe and maybe in the whole world.
From the ancient times Cuba attracted lots of tourists with its culture, history, traditions and pure Cuban architecture. As it is known Cuba has been a colony of Spain during 500 years. This quite a long period has left its traces in Cuban culture. Also slaves from Africa have taken their own traditions and habits with them. It also reflected in the country and at least it became a country with mixture culture.
Cuba is famous with its exotic food, festivals, carnivals and other interesting events.
Therefore this situation makes Cuba one of the important touristy countries in the whole world.
Egypt is one of the famous countries with tourism. Tourism's relation with Egypt will help to Georgia with its development in tourism and culture, which has a great meaning to our economy. Georgia has trading and cultural links with Egypt from ancient time, which continuos now.


MSC Cruises has created a new management position to consolidate its Florida-based operations. Starting February 4, Ken Muskat will return to the company as its EVP Chief Operating Officer for the U.S., where he will directly oversee all major trade- and consumer-facing functions in the market.
"North America is quickly becoming our most important source market, thanks to the investments made in new hardware as well as infrastructure to meet growth in demand for our product by guests from across the U.S. and the overall region," said MSC Cruises' CEO Gianni Onorato in a written statement.
In his new role, Muskat will report to Roberto Fusaro, MSC Cruises' president for North America, and will directly manage all travel trade-facing functions as well as Hotel Operations, Contact Center, Revenue Management, Marketing and Communications. The new position now places the local management in charge of the company's upcoming Ocean Cay MSC Marine Reserve project and the recently-announced development of a new, dedicated MSC Cruises terminal at PortMiami.
"Wanting to ensure that especially the Ocean Cay MSC Marine Reserve gets the necessary attention from our local team to guarantee it meets and exceeds the expectations of North American consumers and travel agent partners made this the next natural step," Onorato added.
Ken Muskat will work together with Fusaro and Rick Sasso, Chairman North America, out of MSC Cruises' U.S. headquarters in Fort Lauderdale.


Samsung's new Galaxy M10 and Galaxy M20 smartphones are now available for purchase in India. Officially announced on January 28th, the Galaxy M10 and M20 are amazingly well priced budget phones from the Korean giant that will take on the competition from Chinese manufacturers such as Xiaomi in the Indian market. Both phones are exclusive to Amazon and Samsung's official online store, which is partly the reason why Samsung has been able to price them so aggressively.
The M10 and M20 get a common rear camera setup with a 13MP primary camera and a 5MP ultra-wide camera. For selfies, there's an 8MP camera on the M20 and a 5MP camera on the M10. The M10 and M20 feature 6.2-inch and 6.3-inch Infinity-V displays (Samsung's brand name for displays with a waterdrop notch) and are powered by the Exynos 7870 and Exynos 7904 chipsets respectively. The Galaxy M20 comes with a gargantuan 5,000 mAh battery with fast charging support while the M10 gets a 3,400 mAh battery but no fast charging. Both phones run Android 8.1 Oreo out of the box and are slated to receive Android Pie in August this year.
The Galaxy M10 is priced at ₹7,990 for the 2GB+16GB configuration and ₹8,990 for the 3GB+32GB variant. The Galaxy M20 costs ₹10,990 for the 3GB+32GB variant and ₹12,990 for the 4GB+64GB model. Samsung has a few launch day offers for the two devices, including additional mobile data and zero-cost EMI plans. Color options for both include Charcoal Black and Ocean Blue.
You can buy the phones on Amazon at the links below and at Samsung's store here; you might want to hurry, as it seems stocks are in limited supply. If you're looking at the Galaxy M20, don't forget to check out review of the phone. Spoiler alert: We like it a lot, and it's a great deal for the asking price.
Update: It seems Samsung has opted for a flash sale model for the Galaxy M10 and M20 on Amazon, with the next sale set to go live on February 7. This is how Chinese OEMs sell their devices in the initial few months, and it looks like Samsung is following the same path.
Best lockscreen ever. It's easy to understand as it is a short summary that tells me the whole story.
What is flash sales model ?
It means you can pay in parts for 6 or 9 or 12 months without paying any interest charges to the lender bank or financial institutions..


text:
Q: How to get the UI behavior when changing mail format to html? The behavior when I change the format of a reply mail from Plain Text using Outlook VBA is not same as when using the Format Text/Format/HTML menu.
My original outgoing mail, just after hitting the Reply button looks as follows:

If I then click the HTML button it remains exactly same ,
except for changing the format to HTML after which I can change the font, size etc.
But if I instead change the format in a macro using
...BodyFormat = olFormatHTML

(see complete code at bottom) then

*

*the leading blank line gets deleted

*the mail headers get deleted

*font changes to Times New Roman 10

Is there a way to get the UI behavior?
The macro body is as follows:
Sub ChangeToTextStyle()
Dim objItem As Object
Dim objMail As MailItem
On Error Resume Next

Set objItem = Application.ActiveInspector.CurrentItem
If Not objItem Is Nothing Then
    If objItem.Class = olMail Then
        Set objMail = objItem
        objMail.BodyFormat = olFormatHTML
    End If
End If
End Sub

UPDATE
Minor problems after following Eugene's answer:
Inserting objMail.Save before changing the format preserves the header and blank lines but the font changes to Times New Roman instead of Lucida Console, which is what I have set in options for composing and reading plain text mail. The original text shows up in 10pt and the cursor is at 12pt. How do I
- Change font to Lucida Console 9.5pt for all the text in mail?
- Change color at cursor to wdDarkRed?

A: It seems you need to Save the mail item and close the inspector window to apply the changes to the UI. Outlook doesn't reflect changes immediately in the UI. Sometimes you need to re-open the message.

A: Try ExecuteMSO - http://msdn.microsoft.com/en-us/library/office/ff862419(v=office.15).aspx
"Works on controls that are built-in buttons..."
Sub ChangeToTextStyleHTML()
Dim objItem As Object
Dim objMail As mailitem
On Error Resume Next

Set objItem = Application.ActiveInspector.currentItem
If Not objItem Is Nothing Then
    If objItem.Class = olMail Then
        ActiveInspector.CommandBars.ExecuteMso ("MessageFormatHtml")
    End If
End If
End Sub

There are other ways but you can see MessageFormatHtml, the IdMso, as the last bit of text when you hover over the selection when adding a built-in button for the Quick Access Toolbar or a ribbon.

A: Otherwise you can just set the email into html format by replacing your code with the below:
Sub ChangeToTextStyle()
Dim objItem As Object

Dim objMail As MailItem
On Error Resume Next

Set objItem = Application.ActiveInspector.CurrentItem
If Not objItem Is Nothing Then
    If objItem.Class = olMail Then
        Set objMail = objItem
        .HTMLBody = .HTMLBody
    End If
End If
End Sub

That worked for me.

A: Below code works for me:
objItem.BodyFormat = olFormatHTML

redpajama_set_name: RedPajamaStackExchange


Republican presidential candidate Donald Trump, and his wife Melania Trump, are interviewed by co-host Matt Lauer, third left, and Savannah Guthrie, right, on the NBC "Today" television program, in New York, Thursday, April 21, 2016.
CLEVELAND (Reuters) - Donald Trump's tough talk on law and order in a time of growing national insecurity appears to be winning over some of his fiercest skeptics - women initially put off by his swaggering tone, his clashes with female critics and past affairs.
But so far those are mostly conservative women. As Trump hones his message, the challenge is to make it also resonate among independent or undecided female voters who are crucial to his hopes of winning the U.S. presidential election in November.
Turmoil on the streets both abroad and at home could give Trump a new opportunity to do just that.
On Monday, Trump tried to seize it with an evening program at the Republican National Convention with several women speakers, including his wife Melania, focused on security. She told the convention that her husband would offer the country new leadership and keep it "safe and secure."
Americans have been rattled by recent attacks in France and Florida, the murder of police officers in Texas and Louisiana, and widespread protests over the killings of unarmed black men, polls show.
"We're not electing a husband, we're not electing a preacher, we're electing a leader," said Kay White, a Republican delegate to the nominating convention from Tennessee who originally supported U.S. Senator Ted Cruz of Texas in the early nominating contests, or primaries.
For White, it's a one-issue election. "Security," she said. "Nothing else matters."
A year ago, Penny Nance, president of Concerned Women for America, a conservative advocacy group, was a blistering critic of the thrice-marriedTrump because of comments he made about Fox News anchor Megyn Kelly that many felt were sexist.
But Nance now supports Trump and says the candidate can fashion an effective message for women centered on national security, she told Reuters on the sidelines of the convention. "Every day we wake up and get our kids ready for school and the television is on and there is another attack," she said.
For Trump, independents will be a tougher sell. A majority of women who identify as "independent" continue to hold an unfavorable opinion of him.
According to a Reuters/Ipsos opinion poll from June 1 to July 15, 64 percent of independent women voters expressed a "very unfavorable" or "somewhat unfavorable" view of Trump. That compares with 89 percent of Democratic women voters and 31 percent of Republican women voters who have a similarly unfavorable view of the New York businessman.
Trump isn't the first candidate whose tough talk on security has won over women voters. George W. Bush used the same message in his re-election campaign in 2004, in the midst of his "war on terror," to appeal to so-called security moms who were concerned about terrorism.
Bush garnered 48 percent of the vote of American women in that election. By comparison, Republican candidate Mitt Romney drew 44 percent in 2012, a full 10 points behind President Barack Obama.
Trump has had trouble convincing women nationally to support him ever since he entered the race in the summer of 2015, according to Reuters/Ipsos polling. Among women who are expected to vote on Nov. 8, a majority expressed an unfavorable opinion of him every time they were asked in the polls.
This month, women appeared to have soured even more on the likely Republican nominee: 69 percent of likely women voters expressed an unfavorable opinion of Trump in the latest July 11-15 Reuters/Ipsos polling, up from 63 percent in the five-day poll that ended on July 1.
Jen Lawless, director of the Women and Politics Institute at American University, said she doubted Trump could rehabilitate his image with most women voters, saying his conflict with Kelly, in particular, had lasting damage.
"I think that ship has sailed," Lawless said.
Trump's problems with women were dramatized on Monday when Women forTrump, a voter-support group, held a sparsely attended event in Cleveland.
The moderator, Jennifer Hulsey, appeared to speak for a lot of women who have found a way to support Trump. "He's not perfect, but neither am I," Hulsey said.
Some of the women delegates interviewed by Reuters at the convention on Monday were scornful of the criticism of Trump's attitude toward women, pointing to his daughter Ivanka, who is a top executive in the TrumpOrganization.
Ivanka and his other daughter Tiffany are due to speak at the convention this week.
"He was not my first choice or even my second choice," said Carol Del Carlo, a Trump supporter. But, "I look at him and I see how he treats his daughters. They're engaged, they look like a real, true family, they work in their father's business, they're advisors."


We will produce a report that a) identifies a set of practices likely to deliver additionality and related outcomes, b) assesses performance of selected programs against these practices, and c) provides guidance to support improvement and scale-up. Information will be generated in a participatory manner, combining in-country dialogues, expert consultations, and a desk review of available information. Our goal is to make recommendations that are politically practical and take into account findings from the best available science.
Interim results will be presented at the ASL Regional Workshop scheduled for May in Leticia, Colombia. A final report will be available in July 2019.
The Amazon Sustainable Landscapes Program (ASL) was approved by the GEF Council in October 2015. With a commitment of US$113 million of GEF resources and an expected US$682 million leveraged in additional financing, the ASL Program aims to protect globally significant biodiversity and implement policies to foster sustainable land use and restoration of native vegetation cover. The Program aims to maintain 73,000,000 hectares (ha) of forest land, promote sustainable land management in 52,700 ha, and support actions that will help reduce CO2 emissions by 300 million tons by 2030.
The ASL Program is a Global Environment Facility (GEF) funded initiative implemented by the World Bank and several other agencies.


Just in time for the Quiltcon deadline, I finished my Hyperspeed quilt for entry! I designed Hyperspeed in response to the All People Quilt – Nine-Patch Challenge, for whatever reason a challenge always put my brain on alert for the perfect idea.
As I was finishing the binding, I was dreaming of the ideal photo for this quilt, and thankfully the weather and my family cooperated! Having the snow to obscure the view and showcase the quilt was just what I was hoping for.
I had designed Placid Curves for my Modern Neutrals book, and loved the movement made with the squares and rectangles. After quite a few steps in EQ7 I had a nine-patch design that I loved and really wanted to make for the challenge. That was in September, and I shared a little bit of my progress here, thankfully I was eager to work on it, since a couple deadlines came and went in the midst of making this one!
Quilting detail – I quilted a nine-patch over each square or rectangle in the quilt. Some of them are wide like this, but in the center they are very close together. The center blocks measure 1 1/2″ x 1 1/2″ so each little square is 1/2″ finished. To quilt in both directions on the long arm, I first quilted in one direction, removed the quilt and trimmed the edges a bit, then reloaded the quilt to quilt in the other direction. This was a first for me, and a good challenge!
To finish the quilt, I wanted the binding to blend into the background. This Dear Stella print had just enough grey, and the tiny print made it a perfect choice.
I backed the quilt with Moda CrossWeave in black, making it very soft and comfy for binding time.
I purposefully used a variety of prints in similar tones, to add interest, and movement in the quilt top. In this photo you can see that the center of the 9-patches are the same in each round radiating out from the center, with the deepest tone in the center of the quilt.
One more shot without the snow. I love the full effect, hopefully Hyperspeed will be hanging at Quiltcon in a few months – I'll keep you updated as I know more It will definitely be hanging at Quiltcon, just got my acceptance email! I'm working on a pattern for Hyperspeed so you can make your own, be sure to add you are signed up for my emails to be notified when it's ready.
Amy, this looks amazing. Love your take on the nine patch challenge.
What a terrific design! It sounds like you finished it up at hyperspeed, too.
I absolutely love this. Definitely one of my favorite quilts of 2016!!! I love the tonal values and the movement. Great choice on that binding fabric too!
Amy love your quilt. May be just the ticket for a quilt for my sister.
Love this, Amy! Can't wait to see it in Savannah!
Great design and beautiful execution! I especially like the nine patch quilting. Congratulations on the acceptance to QuiltCon. I can't wait to examine it in person!
I'm really excited I found this. I'm taking your class at Quiltcon 2018. I can't wait to meet you and see your gorgeous quilt.


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"Andrews pulls out all the stops… and he has masterfully interwoven past, present and future into a story that will have you on the edge of your seat from beginning to end"
Feeling Fictional
"Fun, fast and furious… a huge step-up from Timebomb. It will leave you demanding more"
Escapades of a Bookworm
"a thrilling and well-developed SF adventure, the characterisation is as multi-dimensional as the time-travel plot"
There are risks to tampering with established events… timelines become snarled, histories become tangled… and one false move could destroy time itself!
Jana, Kaz and Dora have escaped from their mysterious enemy, Quil, wounded and scared. Taking refuge in a place outside of time, they devise a plan to change the past, altering Quil's life so that she never meets them.
From the streets of Beirut in 2010 to the domed cities of Mars in 2155 and beyond, the three teenagers fight for their future, and that of all humanity, by trying to rewrite the history of the person who has sworn to destroy them.
What could be more complicated – and important – than trying to save the world? As their feelings for each other grow stronger, though, Jana, Kaz and Dora find themselves at the centre of a different kind of battle. And when it comes to matters of the heart, there can be no real victors.
Buy at Amazon.co.uk
Buy at Amazon.com
Goodreads reviews for Second Lives
More reviews from Goodreads.com


Welcome 2016 I am so glad to see you. Let's get off on the right foot. I would like us to have a wonderful year together. I'd like to remember you in years to come as one of the best years of my life. So here is to you! Let us make it one to remember!!!
I usually choose one word to think about in my year instead of loads of resolutions I will not keep. Yes I know I need to exercise and eat better. I need to slow down and think about the beauty in my life. I need to be much more positive than I am, but all those resolutions just get jumbled in my head and get me nowhere fast. So a word works better for me. The last few years have been hard, really hard if I am honest. Much I talk about but a lot I don't because it is not my story to tell, but I am still here kicking and screaming and looking forward to better things. So instead of one word I am picking four this year because one word is just not going to be enough for me.
I think that sums it up and I think that covers everything. I have those precious words written by my computer, in my closet, on my bathroom mirror and in my car just to remind myself of my 2016 mantra.
Love, Happiness and Abundance in 2016.
Wonderful words! I a hoping for a great 2016!
I will also adopt your words. Now it's about that Hibiscus! Where did you get that? I've wanted to get a super vibrant one like that. I look forward to a whole year of friendship with you!
I'm with you Meredith. I, too, wish for all of us peace, love happiness and abundance.
Just love reading your blog and seeing pictures of little Buddy and any others you share.
I don't blog. Just enjoy others' blogs by way of Pammy Sue.
I'm so glad you're thinking ahead and keeping these important concepts in mind. You will have a good year, I am sure. I wish you and your family all the best in 2016.
Great words for the new year!
I love the words you chose this year Meredith. Can you imagine if everyone adopted and LIVED BY those words? This world would be so much better. I wish each and everyone for you my friend.
Lovely photos and Happy New Year.
I often read but haven't commented. I love your blog!
What a fantastic hibiscus! Great word choice, all four of them. Our world needs to adopt these words, too! Happy 2016!
I wish you all the best in this New year dear Meredith.
Maybe a bit of good luck will work too ? You sure deserve it!!
4 great words that I will also adopt. Have a wonderful New Year.
Abundance ! good one!!! Abundance of knitting!
Wishing you a very Happy New Year Meredith - wishing you much peace and happiness.
Happy New Year dear Meredith.
It is a great idea to bring all those thoughts, feelings and hopes into one, (or a few) special words. If I had to pick a word for myself, it would be clarity. My goal is to see more clearly, understand more thoroughly and be far less judgmental. It is also my hope, that I will feel others judgement towards me, far less.
It will be an interesting journey, and it is so wonderful to be in it together via our little pen-pal-ship.
Wishing you a very happy New year to you and your family, may it indeed bring us all Peace,Love,Happiness and Abundance!! I could not ask for more......Well said!!!
My word for 2016 is joy --- as in "does it bring me joy?"
If it does not.....it must go.
Wishing you and your family a blessed and JOYFUL 2016!
May 2016 bring you all that you wish for dear Meredith.
My year ahead doesn't promise much more than my year behind so I'm expecting nothing from the months to come and shall simply be celebrating small joys.
Happy New Year Mere. Wishing you these four words and so much more. All the best.
Happy New Year! I hope it is your best year yet!
I like your words for the year, Meredith. Wishing you all of these things for 2016. I love the tradition of choosing a word or words for the year. My word for this year is Clarity.


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BOCC rejects BRW Bid
At the regular meeting on September 8, 2020, the Board of County Commissioners rejected BRW Contracting's (BRW) bid on the resurfacing of Snow Hill Road and Jones Road. Despite being the lowest bidder, a verified history of fraud and unsatisfactory work on the Osowaw Blvd resurfacing project was the top reason for the unanimous decision.
The contract will instead be awarded to the second-lowest bidder, Goodwin Bros Construction, though their price for asphalt preparation was higher.
Purchasing and Contracts Manager James Wunderle explained that BRW is not legally barred from Hernando County, however, Commissioner Jeff Holcomb provided a deeper explanation of the past work and contracts from BRW.
After the submission of a police report from a competitor contractor of BRW, Holcomb explained that he started skeptically however, verified the sources. "This report indicated BRW purchased a subpar product from Cemex," after which they were found to have falsified the actual product information and submitted that ticket to the county. Holcomb continued, "None of that is legal, obviously."
Holcomb went on to say that the owner of BRW was "sentenced by the federal government to two years in prison, stemming from an affirmative-action fraud scheme." Holcomb concluded that with the federal fraud charges, charges of fraud in Hernando County, and reported examples of unsatisfactory work from the City of Brooksville, "they will not be getting my vote to work for this county."
John Allocco added, "While there is no legal impediment, according to the legal department, there is no legal requirement, either." Allocco explained his concerns about value over cost, and stated "the numbers (bid prices) are not that much different" and also had concerns about extra staff hours required for supervision of BRW having knowledge of the previous problems.


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We have been contacted by a TV production company – Wonder TV – who have been commissioned by the BBC to make a documentary about people living with dementia. Would you or someone you know be interested in taking part in this film? Please pass on the poster and information below – you can either…
A Walk to Remember 2019…We Raised £2,464!
Thank you to everyone who came along to our Walk to Remember on Sunday 2nd June. We had a wonderful morning walking…despite the drizzly weather! A special thank you to Edmundson Electrical for very kindly sponsoring the event Thank you to Staffordshire Police Cadets for marshalling and their continued support at our…
Approach to Hold Monthly Dementia Information Stalls at The Royal Stoke University Hospital
Approach is pleased to be working in conjunction with the lead Dementia Nurse at University Hospitals of North Midlands NHS Trust to hold monthly dementia information stalls at The Royal Stoke University Hospital to offer patients, carers and relatives support and information. Our first information stall will be in the Hospital Foyer on Thursday 24th…
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Kate's Dream Riders have raised an outstanding £425 for Approach following their ride out to Llandudno. The motorcycle group was initially set up to raise funds to support their name sake, Kate Madeley fund her bucket list dreams after she was diagnosed with cancer. The group also now fundraise to help other local causes continue…
The Association of Mirpur Welfare Fund Generously Donate £250 to Approach
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Has the height issue been resolved that was mentioned in the reviews a number of years ago? Specifically, can we stack these on top of each other in the rack or is the height causing us to skip positions. Evidently someone didn't know what 1U limitations were.
Super heavy duty with hundreds of uses besides racks. Use your imagination. I did, now I cant stop buying them! Made of STEEL! Steel is the ultimate! Know why? It never goes away!
Will be cleaning up my server rack after I do some power line rewiring.
Great deal, work well. One nit.
These are very good for the price. The rings are a little softer than I hoped. I wish they had vertically oriented D-Rings at the ends to help me tidy vertical runs along the edge of the rack but I realize that for 1U, that may not make as much sense. I have now purchased 7 of these!
Shopping online this was the lowest cost. All metal construction.
The part is a good quality part and should do the job just fine. Unfortunately, though, the D rings were too big to be used inside my enclosed rack. If you have a door on your rack be sure and measure that you have about 4" of space between the rack and the inside of the door.
Works great holding my network cables between the patch panel and switch. Will probably order another in the future for my A/V patch panel.
PROS: Feel well built and the prongs can be manually bent to wider/narrower openning to accomodate different sizes of cable.
CONS: It could use 1 or 2 more "prongs" along the length to keep the more flexible cables from leaking out.
Good quality, metal construction. Can't go wrong.
PROS: Really good looking bracket, with the sweet monoprice logo. It's clips are metal, so don't expect it to break like my plastic bracket, on my non monoprice one. I used mine by drilling it to a wall for cable management.


Featured Fiction: "Shall We Dance"
Missy had prodigious aspirations for me and I counted the ticks of her grandfather clock. This got me into a heap of trouble and I hated to be scolded, especially since I was paid by the hour. Missy was married and lonely. Her husband messed around with junk bonds or depressed assets. It kept Missy in mink and Picassos on the walls. The place smacked of good breeding or, at least, had a sharp interior decorator. Trendy made way for style, right down to the snazziest lampshades. She had a chauffeur, a personal masseuse, "a tennis pro," a gardener who tended to the forsythias on the balcony, and metaphysician who helped iron out her wrinkled thoughts. In a pinch, she could score a quartette from the Philharmonic to play Berlioz or Debussy or whatever the heck she wanted in her living room. I was her dance partner.
We hooked up because I answered the ad she'd tacked up at my coffee shop. I was saving to buy a new laptop since my old one stunk. Too many keys were missing and the ones that hung on were wobbly and had muffin crumbs, hiding under their springs. It was a bona fide monstrosity, an antique by today's standards, but I kept it. I've always had a soft spot for clunkers.
Missy didn't pay me the first few times we tangoed. She was too much of an artiste to be bothered by such garish frivolities. Also, she never carried cash. After the third session, she got the sense I wasn't a happy camper so she sent Milty, the valet, out shopping. He brought me back a periwinkle Hermes scarf and a pair of Valentino loafers. The deuce was hands down the nicest gift combo anybody on this mudball had ever given me, but I had a small gripe. I still hadn't been paid.
Perhaps I'm a big creepola for mentioning something so petty, but how could I explain my relationship with Missy if I wasn't on the payroll. For the record, I wasn't sleeping with her either, which doesn't necessarily mean I couldn't have also been on the payroll. Claude, her "tennis pro," boffed her brains out. This was, of course, according to Diego the gardener, Missy's erstwhile paramour (former boffer to the layperson).
Frankly, I didn't care to evince Claude and become Missy's "tennis pro." I wanted some clarity regarding my status. Say I'd planned on counting this dancing stint on my résumé how was I going to explain to my future employers that I didn't receive a salary or an hourly wage. The lady bought me toys. Nice as these trinkets were, I wanted, well, more. Not materialistically speaking. I wanted my input to be considered. Don't get me wrong that scarf and those loafers turned me into a Masterpiece Theatre gentleman. But could I look myself in the mirror? The answer was unequivocally yes. I liked what I saw and I enjoyed the whole kooky experience. So I told myself not to be so petty about the money thing.
For a while this worked. Eventually though my lofty ambitions lost steam. My big qualm was not having a clearly defined incentive and this went right to the very heart of my makeup (DNA for all you science nuts). You see, I'm the kind of person who needs to walk by a shop window and see the shiny blue bicycle before the butterflies start swarming in my belly. I mark Xs on the calendar to know how long it will take to ride off into the sunset. As a matriculated city college student that shiny blue bicycle was a brand new computer.
While my newfangled self continued blossoming, my computer kept crumbling. I took to writing my term papers longhand and my professors started to give me the stinkeye. You probably already know that if a sophomore gets a certain reputation his chances of making the Dean's List are slim to none. I'm not a status person per se, but I needed my professors to respect me. I also tried not showing up to class too foppish. There was no need giving them any ideas that I might be of the trust fund persuasion. I showed up mostly in jeans and t-shirts, but once a week, when I was heading over to Missy's, I was dolled up in Oscar de la Renta.
When we first started dancing she kept adjusting my feet, my hands, my head. She clapped so I'd capture the beat. She made a smashing gadfly. She carried a professional's air though I knew she was merely a passionate enthusiast. Soon our steps began to sync. Missy's spirit was ebullient, her body lithe and sinewy. She kept her cheek a hanky-crease from mine and sometimes looped her leg round my calf when I took her for a dip. Her pecan-brown eyes simmered. We danced to Astor Piazzola who she'd met twice, once while vacationing in Mar de Plata as a twenty-something and again many years later at a benefit in Paris. With a wink, she told me she only let him kiss her hand. We traipsed throughout the ballroom and I felt as if Missy was back on the debutante circuit and I was her mustachioed Tango King.
I had a crush on this new incarnation of myself. Maybe I originally took on this tango challenge as a lark, but the more I danced, the more I was regaled with Missy's passion for this Argentine waltz, the more it became part of me. Whenever my roommate ducked out, I practiced in front of the mirror. Between commercials and breaks from Psych and Macro Economics, I worked on my steps. I bought a jar of hair gel and slicked back my locks.
When I showed up for our sessions, Missy appraised me as I imagined she might, considering a new Picasso. She'd tell me bluntly how many hours I'd practiced during the week and was almost always on the money. We never discussed my studies although I touched upon it a couple of times, mainly to bring up the fact I needed a new computer.
She was deep into one of her South American ruminations, when I decided I'd had enough. If I had to hurt her feelings so be it. How long did I have to suffer writing longhand? We sat at the table, nibbling on cucumber sandwiches. Prescott, the butler, served us herbal tea from a Russian samovar.
"You're not bailing out on me already" Missy said, putting down her teacup.
Her eyes sort've bugged out as I mentioned this vial and detestable piece of news. I might as well have been reciting free verse from a bathroom stall. I knew I couldn't take back what I'd said in that instance, and that in all likelihood, things would be different from that point forward. She caught me completely by surprise, suggesting we go out to dance. It was time.
The following night we met at a lounge over on Stanton. I was so excited on my walk to see her that I didn't even bother fixing the bunch in my right sock. On a plain vanilla day, a bunched sock could be as excruciatingly annoying as walking with a pebble in your shoe, but my reckless glee had me, hovering at least three feet above the cracks and gum splotches in the pavement. When I got there she was already by the bar, sipping on a mojito. For the first time, she let me take the lead and I escorted her to the dance floor. We kept great restrain though I felt a simmering undercurrent, burbling between us. I had on too much cologne and it whisked beyond my open collar and when the strobe light hit my bald cheeks I felt like I was glowing. Nothing in my life topped that glimmering moment until I noticed all the eager, lust-filled mouths, twirling around us. Bright red lips and sweaty cheeks. Still hands without a sense of place. I got antsy and our ages didn't sync. Really though, I was embarrassed to be seen in public, dancing with such passion.
We stopped to catch our breath. Missy slugged back her mojito and I tried not to touch her knee. How strange when we clasped hands and brushed waists as we tangoed. Those were the rules of engagement. Now we lapsed into a hopeless lull, without rhythm. Maybe I was afraid of kissing her or being kissed by her because I hadn't yet explored the fantasy and the moment was unfolding too fast. We sat swathed in mutual curiosity, my long fingers longing for something to roam as her liquid brown eyes studied me. I was ready to trade almost anything to know what she was thinking. How cruel the quiet and selfish mind. She bit her lip gingerly and found repose. Then she removed the cameo from her necklace and slipped it into my closed hand. First time she'd given me a piece of herself. It delighted and unsettled me.
Now I'm left with the wan smile from her cameo. It eyes my typing fingers from the nightstand and makes me wonder.
John's a recovering anthropologist and a Trilobite wonk. He enjoys fried pickles and hoppy beers. His work has appeared in Monkeybicycle, Gravel, Newtown Literary, and Writer's Digest. His debut novel Shades of Luz is called a modern day Don Quixote. He snagged his MFA in Creative Writing from Pacific University.
Featured Poem: "The Language of Love"