text:
Effect of two lipid-lowering strategies on high-density lipoprotein function and some HDL-related proteins: a randomized clinical trial
Chan Joo Lee, Seungbum Choi, Dong Huey Cheon, Kyeong Yeon Kim, Eun Jeong Cheon, Soo jin Ann, Hye Min Noh, Sungha Park, Seok Min Kang, Donghoon Choi, Ji Eun Lee, Sang Hak Lee
Background: The influence of lipid-lowering therapy on high-density lipoprotein (HDL) is incompletely understood. We compared the effect of two lipid-lowering strategies on HDL functions and identified some HDL-related proteins. Methods: Thirty two patients were initially screened and HDLs of 21 patients were finally analyzed. Patients were randomized to receive atorvastatin 20 mg (n = 11) or atorvastatin 5 mg/ezetimibe 10 mg combination (n = 10) for 8 weeks. The cholesterol efflux capacity and other anti-inflammatory functions were assessed based on HDLs of the participants before and after treatment. Pre-specified HDL proteins of the same HDL samples were measured. Results: The post-treatment increase in cholesterol efflux capacities was similar between the groups (35.6% and 34.6% for mono-therapy and combination, respectively, p = 0.60). Changes in nitric oxide (NO) production, vascular cell adhesion molecule-1 (VCAM-1) expression, and reactive oxygen species (ROS) production were similar between the groups. The baseline cholesterol efflux capacity correlated positively with apolipoprotein (apo)A1 and C3, whereas apoA1 and apoC1 showed inverse associations with VCAM-1 expression. The changes in the cholesterol efflux capacity were positively correlated with multiple HDL proteins, especially apoA2. Conclusions: Two regimens increased the cholesterol efflux capacity of HDL comparably. Multiple HDL proteins, not limited to apoA1, showed a correlation with HDL functions. These results indicate that conventional lipid therapy may have additional effects on HDL functions with changes in HDL proteins.
Published - 2017 Feb 28
Biochemistry, medical
Fingerprint Dive into the research topics of 'Effect of two lipid-lowering strategies on high-density lipoprotein function and some HDL-related proteins: a randomized clinical trial'. Together they form a unique fingerprint.
Atorvastatin Medicine & Life Sciences
Vascular Cell Adhesion Molecule-1 Medicine & Life Sciences
Ezetimibe Medicine & Life Sciences
Lee, C. J., Choi, S., Cheon, D. H., Kim, K. Y., Cheon, E. J., Ann, S. J., Noh, H. M., Park, S., Kang, S. M., Choi, D., Lee, J. E., & Lee, S. H. (2017). Effect of two lipid-lowering strategies on high-density lipoprotein function and some HDL-related proteins: a randomized clinical trial. Lipids in Health and Disease, 16(1), [49]. https://doi.org/10.1186/s12944-017-0433-6
Lee, Chan Joo ; Choi, Seungbum ; Cheon, Dong Huey ; Kim, Kyeong Yeon ; Cheon, Eun Jeong ; Ann, Soo jin ; Noh, Hye Min ; Park, Sungha ; Kang, Seok Min ; Choi, Donghoon ; Lee, Ji Eun ; Lee, Sang Hak. / Effect of two lipid-lowering strategies on high-density lipoprotein function and some HDL-related proteins : a randomized clinical trial. In: Lipids in Health and Disease. 2017 ; Vol. 16, No. 1.
@article{58ce173decc14a95b93b83dda1eb098f,
title = "Effect of two lipid-lowering strategies on high-density lipoprotein function and some HDL-related proteins: a randomized clinical trial",
abstract = "Background: The influence of lipid-lowering therapy on high-density lipoprotein (HDL) is incompletely understood. We compared the effect of two lipid-lowering strategies on HDL functions and identified some HDL-related proteins. Methods: Thirty two patients were initially screened and HDLs of 21 patients were finally analyzed. Patients were randomized to receive atorvastatin 20 mg (n = 11) or atorvastatin 5 mg/ezetimibe 10 mg combination (n = 10) for 8 weeks. The cholesterol efflux capacity and other anti-inflammatory functions were assessed based on HDLs of the participants before and after treatment. Pre-specified HDL proteins of the same HDL samples were measured. Results: The post-treatment increase in cholesterol efflux capacities was similar between the groups (35.6% and 34.6% for mono-therapy and combination, respectively, p = 0.60). Changes in nitric oxide (NO) production, vascular cell adhesion molecule-1 (VCAM-1) expression, and reactive oxygen species (ROS) production were similar between the groups. The baseline cholesterol efflux capacity correlated positively with apolipoprotein (apo)A1 and C3, whereas apoA1 and apoC1 showed inverse associations with VCAM-1 expression. The changes in the cholesterol efflux capacity were positively correlated with multiple HDL proteins, especially apoA2. Conclusions: Two regimens increased the cholesterol efflux capacity of HDL comparably. Multiple HDL proteins, not limited to apoA1, showed a correlation with HDL functions. These results indicate that conventional lipid therapy may have additional effects on HDL functions with changes in HDL proteins.",
author = "Lee, {Chan Joo} and Seungbum Choi and Cheon, {Dong Huey} and Kim, {Kyeong Yeon} and Cheon, {Eun Jeong} and Ann, {Soo jin} and Noh, {Hye Min} and Sungha Park and Kang, {Seok Min} and Donghoon Choi and Lee, {Ji Eun} and Lee, {Sang Hak}",
note = "Publisher Copyright: {\textcopyright} 2017 The Author(s). Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",
journal = "Lipids in Health and Disease",
Lee, CJ, Choi, S, Cheon, DH, Kim, KY, Cheon, EJ, Ann, SJ, Noh, HM, Park, S, Kang, SM, Choi, D, Lee, JE & Lee, SH 2017, 'Effect of two lipid-lowering strategies on high-density lipoprotein function and some HDL-related proteins: a randomized clinical trial', Lipids in Health and Disease, vol. 16, no. 1, 49. https://doi.org/10.1186/s12944-017-0433-6
Effect of two lipid-lowering strategies on high-density lipoprotein function and some HDL-related proteins : a randomized clinical trial. / Lee, Chan Joo; Choi, Seungbum; Cheon, Dong Huey; Kim, Kyeong Yeon; Cheon, Eun Jeong; Ann, Soo jin; Noh, Hye Min; Park, Sungha; Kang, Seok Min; Choi, Donghoon; Lee, Ji Eun; Lee, Sang Hak.
In: Lipids in Health and Disease, Vol. 16, No. 1, 49, 28.02.2017.
T1 - Effect of two lipid-lowering strategies on high-density lipoprotein function and some HDL-related proteins
T2 - a randomized clinical trial
AU - Lee, Chan Joo
AU - Choi, Seungbum
AU - Cheon, Dong Huey
AU - Kim, Kyeong Yeon
AU - Cheon, Eun Jeong
AU - Ann, Soo jin
AU - Noh, Hye Min
AU - Park, Sungha
AU - Kang, Seok Min
AU - Choi, Donghoon
AU - Lee, Ji Eun
AU - Lee, Sang Hak
N1 - Publisher Copyright: © 2017 The Author(s). Copyright: Copyright 2017 Elsevier B.V., All rights reserved.
N2 - Background: The influence of lipid-lowering therapy on high-density lipoprotein (HDL) is incompletely understood. We compared the effect of two lipid-lowering strategies on HDL functions and identified some HDL-related proteins. Methods: Thirty two patients were initially screened and HDLs of 21 patients were finally analyzed. Patients were randomized to receive atorvastatin 20 mg (n = 11) or atorvastatin 5 mg/ezetimibe 10 mg combination (n = 10) for 8 weeks. The cholesterol efflux capacity and other anti-inflammatory functions were assessed based on HDLs of the participants before and after treatment. Pre-specified HDL proteins of the same HDL samples were measured. Results: The post-treatment increase in cholesterol efflux capacities was similar between the groups (35.6% and 34.6% for mono-therapy and combination, respectively, p = 0.60). Changes in nitric oxide (NO) production, vascular cell adhesion molecule-1 (VCAM-1) expression, and reactive oxygen species (ROS) production were similar between the groups. The baseline cholesterol efflux capacity correlated positively with apolipoprotein (apo)A1 and C3, whereas apoA1 and apoC1 showed inverse associations with VCAM-1 expression. The changes in the cholesterol efflux capacity were positively correlated with multiple HDL proteins, especially apoA2. Conclusions: Two regimens increased the cholesterol efflux capacity of HDL comparably. Multiple HDL proteins, not limited to apoA1, showed a correlation with HDL functions. These results indicate that conventional lipid therapy may have additional effects on HDL functions with changes in HDL proteins.
AB - Background: The influence of lipid-lowering therapy on high-density lipoprotein (HDL) is incompletely understood. We compared the effect of two lipid-lowering strategies on HDL functions and identified some HDL-related proteins. Methods: Thirty two patients were initially screened and HDLs of 21 patients were finally analyzed. Patients were randomized to receive atorvastatin 20 mg (n = 11) or atorvastatin 5 mg/ezetimibe 10 mg combination (n = 10) for 8 weeks. The cholesterol efflux capacity and other anti-inflammatory functions were assessed based on HDLs of the participants before and after treatment. Pre-specified HDL proteins of the same HDL samples were measured. Results: The post-treatment increase in cholesterol efflux capacities was similar between the groups (35.6% and 34.6% for mono-therapy and combination, respectively, p = 0.60). Changes in nitric oxide (NO) production, vascular cell adhesion molecule-1 (VCAM-1) expression, and reactive oxygen species (ROS) production were similar between the groups. The baseline cholesterol efflux capacity correlated positively with apolipoprotein (apo)A1 and C3, whereas apoA1 and apoC1 showed inverse associations with VCAM-1 expression. The changes in the cholesterol efflux capacity were positively correlated with multiple HDL proteins, especially apoA2. Conclusions: Two regimens increased the cholesterol efflux capacity of HDL comparably. Multiple HDL proteins, not limited to apoA1, showed a correlation with HDL functions. These results indicate that conventional lipid therapy may have additional effects on HDL functions with changes in HDL proteins.
JO - Lipids in Health and Disease
JF - Lipids in Health and Disease
Lee CJ, Choi S, Cheon DH, Kim KY, Cheon EJ, Ann SJ et al. Effect of two lipid-lowering strategies on high-density lipoprotein function and some HDL-related proteins: a randomized clinical trial. Lipids in Health and Disease. 2017 Feb 28;16(1). 49. https://doi.org/10.1186/s12944-017-0433-6


Last weekend, my wife, my son, and I went to the opening nights for the Actors' Theatre one-act production 8 Tens @ 8, which runs through February 3.
This year (2019) is their 24th season for this festival, which has grown to 16 one-act plays (8 on A nights, 8 on B nights). The one-act plays are submitted by playwrights, and a committee of five judges select plays from the submissions for production. This year each of the 16 plays had its own director, and there were 26 cast members each of whom played in one or two plays. Three of the directors (Helene Simkin Jara, Marcus Cato, and Nat Robinson) were also serving as actors (though not in the plays they were directing).
The plays are performed at Center Stage, a small theater that seats 89 people (including the one wheelchair spot). Both opening nights were sold out, but we counted 5 empty seats on Saturday night, so some people must have been no-shows.
I won't provide any spoilers in this post, but I will say that both the A and B nights were equally good (sometimes they pack the best plays into the A night, but this year they seem to have distributed them more evenly). The writing, acting, and directing were a bit uneven, as you would expect with 16 different playwrights, sixteen different directors, and sixteen different casts. One of the good things about one-act plays is that if you don't like one, it will be over soon and replaced by a different one. Overall, I think that the quality was pretty high this year, with at least half the plays being well worth seeing.
The plays are performed as two groups of 4 each night, with an intermission between the groups. In the past, we've noticed a tendency to put the best plays at the end of each group, but they don't seem to have done that this year. Somewhat unusually, the three of us agreed on which one we liked best each night. We liked best Tempus Fugit by Greg Atkins (the first play on Night A) and The Rug by Brian Spencer (the 7th play on Night B).
In the past week, I have bought my season tickets for both Santa Cruz Shakespeare and Jewel Theatre. For both, we ended up buying three subscriptions—for my wife, my son, and me, although there is one of the Jewel Theatre performances that my son will not be in town for.
In fact, we're going to Love's Labours Lost twice, because my mother-in-law will be in town during the previews, when our son can't go, so we'll go with her to the preview and with our son to a showing later in the season.
The Jewel Theatre plays look like an interesting season, though I'm a bit worried about Julie James having cast herself as the lead in the first one—she has a habit of casting herself in parts intended for much younger actresses, and she is almost old enough to be playing the mother rather than the daughter in this play. Still, it is less of a stretch than some of the roles she has tried to pull off in previous years.
This weekend, we are going to a non-subscription theater event: WEST Ensemble Players' production of Antigone. WEST Ensemble Players are the grade 10–12 invitation-only troupe for WEST Performing Arts, and they are usually pretty good. We enjoyed the performance of She Kills Monsters that they did in February.


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Tag: Maven
NASA's MAVEN Selfie Marks Four Years in Orbit at Mars
September 23, 2018 September 23, 2018 News 0
This image is a composite selfie taken by MAVEN's Imaging Ultraviolet Spectrograph (IUVS) instrument that normally looks at ultraviolet emissions from the Martian upper atmosphere. Lines are sketched in to show approximately where components of the spacecraft are that were not able to be imaged due to the limited motion of the instrument around its support boom. Thrusters can be seen at the lower left and right, the Electra communications antenna at the bottom toward the left, the magnetometer and sun sensor at the end of the solar-panels at the upper left, the tip of the communications antenna at the top middle. In addition, the shadow of the IUVS and of its support boom can be seen down the middle of the spacecraft body. (Credits: University of Colorado/NASA)
BOULDER, Colo. (NASA PR) — Today, NASA's MAVEN spacecraft celebrates four years in orbit studying the upper atmosphere of the Red Planet and how it interacts with the Sun and the solar wind. To mark the occasion, the team has released a selfie image of the spacecraft at Mars.
Lucy Asteroid Mission Moves Toward 2021 Launch
May 24, 2018 May 20, 2018 News 2
Southwest Research Institute is leading NASA's Lucy mission, which will launch in 2021 for the first reconnaissance of the Trojans, a population of primitive asteroids orbiting in tandem with Jupiter. In this artist's concept (not to scale), the Lucy spacecraft is flying by Eurybates, one of the six diverse and scientifically important Trojans to be studied. (Credit: SwRI)
The first mission to explore Trojan asteroids that orbit in tandem with Jupiter is moving forward toward a late 2021 launch date using heritage hardware that has already been tested in space, according to a Government Accountability Office (GAO) assessment.
"Project officials characterize the Lucy design as low risk because it does not require development of any critical technologies and has a high heritage design," the GAO found. "For example, these officials stated that Lucy's design has the same architecture as prior NASA projects such as Juno and the Mars Atmosphere and Volatile Evolution Mission (MAVEN).
NASA Year in Review
December 28, 2015 December 27, 2015 News 1
WASHINGTON (NASA PR) — In 2015, NASA explored the expanse of our solar system and beyond, and the complex processes of our home planet, while also advancing the technologies for our journey to Mars, and new aviation systems as the agency reached new milestones aboard the International Space Station.
U.S., India to Deepen Cooperation in Space
January 25, 2015 News 4
President Barack Obama is on a state visit to India. The U.S. and Indian governments released a joint statement focusing on areas of cooperation, including enhanced cooperation in space. The following are excerpts from the statement.
The Prime Minister and the President acknowledged and expressed satisfaction at the qualitative reinvigoration of strategic ties and the intensity of substantive interactions since the Prime Minister's visit to Washington in September 2014. They appreciated the focused action and accomplishments by both sides on the decisions taken during the Summit in September and in this regard, they welcomed:
The 30 September 2014 signing of an implementing agreement between the National Aeronautics and Space Administration (NASA) and Indian Space Research Organisation (ISRO) to conduct the joint NASA-ISRO Synthetic Aperture Radar (NISAR) mission.
President Obama and Prime Minister Modi agreed to further promote cooperative and commercial relations between India and the United States in the field of space. The leaders noted the on-going interactions between their space agencies, including towards realizing a dual frequency radar imaging satellite for Earth Sciences, and exploring possibilities for cooperation in studying Mars.
The Leaders took note of ongoing U.S.-India space cooperation, including the first face-to-face meeting of the ISRO-NASA Mars Working Group from 29-31 January 2015 in Bangalore, in which the two sides will consider opportunities for enhanced cooperation in Mars exploration, including potential coordinated observations and analysis between ISRO's Mars Orbiter Mission and NASA's Mars Atmosphere and Volatile EvolutioN mission (MAVEN). The Prime Minister and the President also welcomed continued progress toward enhanced space cooperation via the U.S.-India Civil Space Joint Working Group, which will meet later this year in India.
MAVEN Enters Martian Orbit
Members of the mission team at the Lockheed Martin Mission Support Area in Littleton, Colorado, celebrate after successfully inserting NASA's Mars Atmosphere and Volatile Evolution (MAVEN) spacecraft into orbit around Mars at 10:24 p.m. EDT Sunday, Sept. 21. (Credit: Lockheed Martin)
WASHINGTON, DC (NASA PR) — NASA's Mars Atmosphere and Volatile Evolution (MAVEN) spacecraft successfully entered Mars' orbit at 10:24 p.m. EDT Sunday, Sept. 21, where it now will prepare to study the Red Planet's upper atmosphere as never done before. MAVEN is the first spacecraft dedicated to exploring the tenuous upper atmosphere of Mars.
NASA Planetary Exploration Highlights From 2013
January 12, 2014 January 11, 2014 News 1
This self-portrait of NASA's Mars rover Curiosity combines dozens of exposures taken by the rover's Mars Hand Lens Imager (MAHLI) on Feb. 3, 2013, plus three exposures taken on May 10, 2013. (Credit: NASA)
NASA Takes a Look Back at 2013
Mars is the centerpiece of NASA's planetary exploration. The Curiosity rover continues to explore the planet, and in its first year already has accomplished its primary goal of determining that Mars could indeed have supported life in the past, possibly much later than originally thought. Curiosity's Radiation Assessment Detector instrument is helping scientists assess round-trip radiation doses for a human mission to Mars.
This Week on The Space Show
December 9, 2013 News 0
This week on The Space Show with David Livingston:
1. Monday, Dec. 9, 2013, 2-3:30 PM PST (5-6:30 PM EST, 4-5:30 PM CST): We welcome back MICHELLE EVANTS for updates regarding X-15 and her book on the subject, "The X-15 Rocket Plane: Flying the First Wings into Space."
2. Tuesday, Dec. 10, 2013, 7-8:30 PM PST (10-11:30 PM EST, 9-10:30 PM CST): We welcome back DR. WENDELL MENDELL. Dr. Mendell is a planetary scientist at NASA JSC. We will be discussing the Moon and much more during this program.
3. Friday, Dec. 13, 2013, 9:30-11 AM PST (11:30- 1 PM CST, 12:30PM-2:00 PM EST): We welcome DR. DAVID BRAIN to the program to discuss the MAVEN mission, Mars, and more.
4. Sunday, Dec. 15, 2013, 12-1:30 PM PST (3-4:30 PM EST, 2-3:30 PM CST). We welcome back ERIC LERNER of Focus Fusion. We will be discussion fusion energy updates with our guest.
MAVEN Set for Launch Monday, NASA Schedules Public Viewing Events
November 17, 2013 November 18, 2013 News 0
Atlas V with MAVEN aboard on the launch pad at Cape Canaveral. (Credit: NASA/Kim Shiflett)
The launch teams are starting the steps to load about 50,000 gallons of liquid oxygen into the first stage of the Atlas V. The lines and tanks have been chilled to accept the minus-297 degree propellant. About 26,000 gallons of refined kerosene, or RP-1, flowed into the first stage fuel tanks during the wet dress rehearsal a couple of weeks ago. Since kerosene doesn't have to be kept cold the way the cryogenic liquid oxygen and liquid hydrogen fuel for the Centaur do, the fuel stayed inside the Atlas tank.
Weather Forecast Remains 60 Percent "Go"
November 17, 2013 – 9:45 AM EST
Forecasters from the U.S. Air Force 45th Weather Squadron continue to predict a 60 percent chance of favorable weather for the launch of NASA's Mars Atmosphere and Volatile Evolution (MAVEN) spacecraft at 1:28 p.m. EST Monday from Cape Canaveral Air Force Station Space Launch Complex 41. MAVEN is scheduled to liftoff atop a United Launch Alliance Atlas V at the beginning of a two hour launch window. Teams are working no technical issues and the countdown is targeted to pick up from the T-6 hour, 20 minute mark at 6:28 a.m. Monday.
NASA Public Viewing Events
Five NASA centers in Washington, Maryland, Mississippi, Alabama and West Virginia will host events and activities Monday, Nov. 18, for the public to view the launch of the agency's Mars Atmosphere and Volatile Evolution (MAVEN) spacecraft and learn about its mission.
Busy Launch Week Begins on Monday with MAVEN Flight
Launch of Atlas V NRO satellite on June 20, 2012. (Credit: ULA)
The numbers are impressive.
6 launches
6 launch vehicles
~ 40 satellites
5 spaceports
That is the week in rocketry that will begin on Monday. The highlights include:
NASA's MAVEN orbiter will study Mars' atmosphere and climate (Monday, Nov. 18 at 1:28 p.m. EST — Cape Canaveral, Florida );
Minotaur I will set a new record for the number of satellites launched into space with by sending the military's STPSat 3 and 29 CubeSats into orbit (Tuesday, Nov. 19 from 7:30 to 9:15 pm EST — Mid-Atlantic Regional Spaceport, Virginia);
SpaceX will attempt to put its first communications satellite into geosynchronous orbit using its upgraded Falcon 9 rocket (Monday, Nov. 25 at 5:37 pm EST — Cape Canaveral, Florida).
Three additional launches will take place from Russia and Kazakhstan over that 7-day period. A table with all scheduled launches is below along with a map showing East Coast residents how they can view Minotaur I's night launch on Tuesday.
NASA to Launch MAVEN Mission to Mars Next Week
Video Caption: Ancient riverbeds, crater lakes and flood channels all attest to Mars's warm, watery past. So how did the Red Planet evolve from a once hospitable world into the cold, dry desert that we see today? One possibility is that Mars lost its early atmosphere, allowing its water to escape into space, and NASA's Mars Atmosphere and Volatile EvolutioN (MAVEN) spacecraft will investigate just that. On September 25, 2013, MAVEN Principal Investigator Bruce Jakosky delivered a presentation at the Smithsonian National Air and Space Museum, discussing NASA's next mission to Mars.
Space 2013: Space Agencies Head for Moon, Mars
Space agencies around the world are planning to launch four missions to other worlds this year, evenly split between the moon and Mars. NASA will orbiters to each destination, while China will attempt to become only the third nation to soft land on the moon. India also looks to make history with its first mission to Mars.
Mistake Costs NASA $10 Million, Two Years and Half of Science Return
NASA awards $485M Mars project delayed by conflict
The Associate Press
"The price of the probe increased by $10 million, its launch was postponed by two years, and the science-gathering mission will be cut in half to one year, an official said. NASA chose the University of Colorado's [MAVEN] proposal to study the Martian atmosphere from 20 other ideas to study Mars that were trimmed to just two before a conflict of interest was declared.
"NASA has not disclosed what the conflict of interest was or who it involved, other than to say last year that it was not created by NASA but by one of the two groups. The space agency said last December that a 'serious' conflict of interest in one of two proposals forced it to disband the board formed to pick the winner, and create a new panel to award the contract."
MAVEN to Challenge Martian Galactic Ghoul
September 16, 2008 News 0
NASA PRESS STATEMENT
NASA has selected a Mars robotic mission that will provide information about the Red Planet's atmosphere, climate history and potential habitability in greater detail than ever before.
Called the Mars Atmosphere and Volatile EvolutioN (MAVEN) spacecraft, the $485 million mission is scheduled for launch in late 2013. The selection was evaluated to have the best science value and lowest implementation risk from 20 mission investigation proposals submitted in response to a NASA Announcement of Opportunity in August 2006.
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Drug-Induced Nutrient Depletion: Beware of medications that rob your body of vital nutrients!
Jun 28, 2013 01:08PM ● By Theresa Luu, M.D.
Are you suffering from a lack of energy? Depression? Memory loss or brain fog? Joint pain and muscle aches? Palpitations? Digestive problems? Chronic pain? Headaches? While these conditions seem unrelated, they may all result from the medications you're taking!
Although prescription and over-the-counter (OTC) drugs can have beneficial and even life-saving effects, millions of Americans suffer from an almost completely ignored epidemic of drug-induced nutrient depletion (DIND) that can cause serious health problems. Most people, including healthcare professionals, are completely unaware of the dangerous side effects these medications create in depleting vital nutrients.In fact, it's estimated that up to 30 percent of pharmaceutical side effects are the result of drug-induced nutrient depletion. Drugscan deplete the body's natural stores of vitamins, minerals, and enzymes. While some of theseside effectsmay be merely unpleasant, others can be life-threatening and can increase the risk of developing other chronic illnesses.
What drugs cause nutrient depletion?
More than 1,000 of the most commonly prescribed prescription drugs and many OTC medications depletethe body of specific vital nutrients. These include the following kinds of drugs:
cholesterol-lowering statins
anti-acid/heartburn
antidiabetic
oral contraceptives and hormone replacement therapy
Who is at risk for drug-induced nutrient depletion?
Most Americans already fall short on their dietary intake of important vitamins and minerals because they regularly eat nutritionally deficient meals, filled with empty calories from high sugar and processed foods, especially fast foods. In fact, a recent study, "What America's Missing: a 2011 Report on the Nation's Nutrient Gap," revealed that 90 percent of Americans are nutrient deficient. Another nutritional survey reported that 80 percent of Americansfail to consume the recommended daily allowance (RDA) for one or more of the essential nutrients on a daily basis. For example, 73 percent of those surveyedwerenot getting enough zinc in their diets, 65 percent were deficient in calcium, 62 percent were low in magnesium, 56 percent in vitamin A, and 54 percent in vitamin B6.If these alreadynutritionally deficient people take medications, thedrugs will further starve their bodies of essential nutrients. And that willincrease their likelihood of developing additional health problems and chronic illnesses, including heart disease, high blood pressure, diabetes, osteoporosis, anemia, and neurologic symptoms.
How many people are at risk of developing drug-induced nutrient depletion?
More Americans than ever are taking prescription drugs; this trendwill continue, along with the increased incidence of chronic illnesses in adults and now even in children, especially obesity, diabetes, gastrointestinal problems, depression and asthma. More than half of all American adults regularly take at least one prescription drug, and one fifth take four or more. One of four children and teenagers is also on a medication for a chronic illness.
Many of the conditions we as physicians see in our everyday practice may actually be related to nutrient depletion. Unfortunately, many physicians try to address the symptoms arising from drug-induced nutrient depletion by prescribing even more drugs, compounding the problem. Therefore, millions of Americans are already suffering from DIND — or at a very high risk of developing it. That depletion has thepotential to create more health problems, leading to more medications, further exacerbating nutritional deficiencies. What a vicious cycle!
Does your doctor know about drug-induced nutrient depletion?
Drug-induced nutrient depletion is a topic that physicians and other healthcare practitioners should be aware of, but most know very little about it. Unfortunately, the subject is rarely part of medical school curricula, so most doctors are unlikely to instruct their patients to supplement the prescriptions they give them. Despite hundreds of scientific studies on DIND that haveappeared in medical journals for decades, throughout the world, most of this information has not been publicized to health professionals or the general public. Fortunately, all this research has been organized and reported in The Drug-Induced Nutrient Depletion Handbook by Ross Pelton, R.Ph., and James Lavelle, R.Ph. More recent books emphasizing DIND are Supplement Your Prescription: What Your Doctor Doesn't Know About Nutrition by Hyla Cass, M.D., and Drug Muggers: Which Medications Are Robbing Your Body of Essential Nutrients —And Natural Ways to Restore Them,by Suzy Cohen, R.Ph.
How do drugs cause nutrient depletion?
Drug-induced nutrient depletion can occur through several mechanisms. Some drugs interfere with the absorption of nutrients, while others may lead to increased excretion. Some drugs may block the action or production of certain nutrients within the cells. Eventually, these nutritional deficiencies can become significant, causing severe side effects, especially when the medications are taken for long periods. Well-known mechanisms are:
1. Absorption – Drugs can change the environment in the gastrointestinal tract in a way that reduces the absorption of needed vitamins and minerals that are in food. For example, anti-acid/heartburn medications decrease the acidic environment in the gut, decreasing calcium absorption that requires an acidic environment for optimal absorption. People who take an acid suppressor can have reduced calcium absorption, leading to risks of osteoporosis and skeletal fractures.
2. Excretion – Some drugs can increase the rate at which the body breaks down a nutrient or eliminates it through the kidneys. Diuretics increase fluid and electrolyte loss through the urine, causing depletion of water-soluble nutrients, including vitamin B, magnesium, and potassium, leading to muscle spasm, cramping, palpitation, and headaches.
3. Metabolism – Drugs can change how the body utilizes certain nutrients or change biochemical pathways involved in the formation of a nutrient. Statin drugs inhibit the pathway of cholesterol production; at the same time, they inhibit the production of coenzyme Q10, which is vital for cellular energy and heart health, causing increased fatigue, muscle aches, or even heart failure.
What can you do to avoid drug-induced nutrient depletion?
Every person who takes or gives prescription drugs needs to know about drug-induced nutrient depletion. The only solution to averting drug-induced nutritional deficiencies is to replace the depleted nutrients through nutritional supplements, dietary sources, or both. If you are one of the many Americans who find yourself needing to takemedications on a long-term basis, then you must supplement the essential nutrients that they steal. Taking a natural supplement along with the medication will replenish the essential vitamins and minerals that are lost. Supplements will not only minimize or prevent unwanted side effects caused by the drug, but also increase the effectiveness and compliance of the medication.
What's the bottom line?
Drug-induced nutrient depletion is a serious issue — and it's not one that's likely to go away, with so many people taking prescription or OTC medications. Patients need to be aware that these medications can lead to severe nutrient deficiencies. And physicians, in evaluating patients' symptoms,need to assess whether those symptoms are due to the illness, to the side effects of the drugs or to nutrient depletions caused by a medication. With appropriate nutritional supplementation, we can controlor at least minimize those side effects andprevent longer-term health complications associated with DIND. It's our chance tolive a longer and healthier life!
Theresa Luu, M.D., a cardiothoracic surgeon, earned a neurobiology degree from the University of Pennsylvania and attended medical school at Emory University, where she completed extensive training and served aschief resident.Through her research in integrative and nutritional medicine and now through the clinical studies she's conducting, she has come to realize the importance of nutritional support for her cardiac patients, both preoperatively and postoperatively, and has seen improved outcomes. She has also led the clinical formulation of the first multivitamin linedeveloped to address drug-induced nutrient depletion (Replenish multivitamins). For more information, visit ReplenishVitamins.com.
Healing Ways Health and Fitness Feature July NCNJ THIS MONTH (Home Page) July 2013 Issue


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Q: vaadin delete row on keyboard event How to handle keyboard event on the selected row in the table?
I mean, for example, I selected a row and I want to delete using keyboard button delete.
How to do it? What listener I should use?

A: You need to use ShortcutListener:
    table.setSelectable(true);
    table.addShortcutListener(new ShortcutListener("", KeyCode.DELETE, new int[10])
    {

        @Override
        public void handleAction(Object sender, Object target)
        {
            table.getValue(); //returns selected rows
            if (getKeyCode() == KeyCode.DELETE)
            {
                System.out.println("Merry Christmas");
            }
        }
    });

redpajama_set_name: RedPajamaStackExchange


Sen. Arlen Specter (R-Pa.) plans to call NFL commissioner Roger Goodell promptly to discuss the Spygate controversy and suggested Sunday that Senate hearings could result from his investigation.
On ESPN's "Outside The Lines", Specter told host Bob Ley that he will call Goodell on Monday morning, just hours after the Patriots and Giants play in Super Bowl XLII.
"It could go to hearings," Specter said. "This is a matter to be considered by the [Senate Judiciary] Committee. I don't want to make any broad assertions or elevate it beyond what I have a factual basis for doing. We're going to follow the facts and if warranted, there could be hearings."
Specter told ESPN's Sal Paolantonio that after hearing Goodell's depiction of why evidence provided by the Patriots was destroyed, he wanted more answers.
"The commissioner's explanation as to why he destroyed the tapes does not ring true," Specter said.
Shortly after Specter's comments Sunday, Goodell said on ESPN's "Mike and Mike in the Morning" that he would be "more than happy to meet with the senator at the earliest possible moment."
Goodell planned to go to the Pro Bowl in Hawaii after the Super Bowl in Arizona, but would adjust his plans if necessary. NFL spokesman Greg Aiello told ESPN's Rachel Nichols on Monday that Goodell would meet with Specter at the end of this week at the earliest, and possible next week if Specter is still interested. Both staffs are working on the arrangements.
Specter wants to know if Goodell spoke to Patriots quarterback Tom Brady to determine if Brady benefited from any of the illegally gathered material.
When asked on "OTL" if he would interview any players, Specter said it was possible, but not a certainty.
it's obviously a very incomplete investigation."
Specter said plans to contact former Patriots video assistant Matt Walsh to see what he knows about the Patriots allegedly videotaping the St. Louis Rams' Super Bowl XXXVI walk-through in 2002. The Patriots have denied they videotaped the practice.
Goodell, who said he reserved the right to address the investigation again if new information arose, said that if Walsh "has information inconsistent with what we have, we want to talk to him."
The commissioner said it's his responsibility to look into any rumor regarding the investigation and dismissed any talk of a cover up.
"People are implying that this is some type of cover up," Goodell said. "... I think it's exactly the opposite.
We were the ones who brought these facts out to light. We were the ones who took the unprecedented discipline to send a very strong message to people [to] don't violate the rules. And I think that's what we want. We want every team playing on a level playing field and I think that's what we have."
After the league investigation into the original Spygate incident after New England's victory over the New York Jets in Week 1, Goodell fined Patriots coach Bill Belichick $500,000, the maximum amount, and docked the team $250,000 and a first-round draft pick. It was the biggest fine for a coach and the first time in NFL history a first-round draft pick was confiscated as a penalty.
"I hope that is not true," Martz said. "I have great respect for Bill Belichick. It's hard to believe that is true. It's a serious allegation and I hope it is not true.
Former Rams quarterback Kurt Warner, currently with the Arizona Cardinals, told Fish that if the league has heard those claims, he is surprised it has not spoken to Walsh. He said if Walsh or any other source has information, it should be investigated.
Walsh has suggested to ESPN.com that he has information that could have exposed the Patriots prior to the Week 1 incident.
"We were aware of the rumor months ago and looked into it. There was no evidence of it on the tapes or in the notes produced by the Patriots, and the Patriots told us it was not true."
Patriots media relations official Stacey James reiterated that sentiment.
"The suggestion that the New England Patriots recorded the St. Louis Rams' walk-through on the day before Super Bowl XXXVI is absolutely false," James said. "Any suggestion to the contrary is untrue."
Rams spokesman Rick Smith, reading a statement from team president John Shaw, said, "At this point, we have no comment."
On Friday, Specter said he had written Goodell seeking an explanation as to why evidence in the NFL's investigation of the Patriots videotaping was destroyed.
"I am very concerned about the underlying facts on the taping, the reasons for the judgment on the limited penalties and, most of all, on the inexplicable destruction of the tapes," Specter wrote.
Specter, the ranking Republican on the Senate Judiciary Committee, said the matter could put the league's antitrust exemption at risk. In a phone interview with The New York Times, which first reported Specter's interest in the matter, he said the committee at some point will call Goodell to address the antitrust exemption as well as the destruction of the tapes.
Goodell, in his previously scheduled news conference Friday from Phoenix, said, "There are very good explanations why the tapes were destroyed by our staff -- there was no purpose for them."
"It's a league matter," he said Friday during his news conference. "I don't know anything about it."
Sal Paolantonio covers the NFL for ESPN. ESPN.com investigative reporter Mike Fish and The Associated Press contributed to this report.


Introducing our April special menu item! The Reuben Dog! Stop by and try! Begins April 2nd!
Here it comes! Keep your eyes out for this during your travels!
Clam digging? Reward your hard work with a delicious Deen Dog!
New addition to our drink menu!
Big News! Our March Special is bringing a Buffalo Chicken Sandwich to our menu! For the month of March, along with our amazing hot dogs, we will be offering a delicious rotisserie chicken sandwich option as well! Don't miss out!
Our Attack of The Mac specials will end February 28th, stop in soon to enjoy any of our 3 Mac Specials before they are gone!
Introducing Deen Dogs "Attack of the Mac" event! Stop in for these delicious specials featuring the ultimate comfort food..Mac and Cheese! Three different items offered for a limited time! Come get your dog on!
Good news! Our equipment is repaired and we will be open our usual hours this Tuesday-Thursday 11am-4:30pm. Stop on by and get your dog on!
Deen Dogs will be closed today, Saturday, February 2nd due to a maintenance issue. Sorry for the inconvenience!
Our "Attack of The Mac" Special Menu items were out of this world! We are thinking of adding one of our Mac Specials to our permanent menu and want your vote! Help us choose the Chili Mac or the BBQ Mac! Not sure, come in and try them both!
Don't forget to join us on Tuesday's and Wednesday's for our Winter Happy Hours! Stop in between 3:30pm-4:30pm and save!
All other dogs only $3.49!
Come get your dog on!
Beginning this Tuesday, January 15th, Deen Dogs will be hosting winter happy hours! Tuesday's and Wednesday's from 3:30-4:30pm, enjoy discounts on all our dogs! Come get your dog on!
Deen Dogs wishes everyone a fantastic New Year! We will be open on New Year's Day from 11am-1:30pm. Come get your dog on before watching the "Dawgs" play the Rose Bowl!
This week only! Stop in and order our German Frischkase dog. If you can pronounce "Frischkase" correctly get a free bag of chips or an extra punch on your Deen Dog Card!
Now through December 22nd, take advantage of our holiday deal! Buy $25 in Deen Dogs Gift Cards, receive a $5 Gift Card FREE!
Thank you for your call in service!!!
In celebration of Small Business Saturday, on Saturday, November 24th we are offering an incredible one day deal-buy $25 in Deen Dogs Gift Cards, Receive a $5 Gift Card FREE! Stock up and save!
Good news! We are now accepting 24hr+ advanced orders! Just call #360-533-8804 to place your orders in advance! Plan ahead and have your order ready at your chosen time!
Reminder! New hours start tomorrow, Tuesday, November 6th!
Stock up now! Not too early! Great gift for the holidays!!! Gift Cards! stocking stuffers, teachers, coaches, babysitters, hairdressers, you name it!!!
Happy Halloween 🎃! Don't forget to stop by for a frightenly good Halloween Dog today!
A spooky treat is coming your way! Order a Halloween Dog! Only available October 31st! While supplies last!
Announcing our updated hours for late fall-winter!
Beginning Tuesday, November 6th, we will be open Tuesday-Saturdays 11am-4:30pm. Thank you for your continued patronage!
Have you tried our Chicago Dog yet?
Reminder: Deen Dogs will be closed this weekend-October 6th-October 7th. Sorry for the inconvenience!
In the summer of 1916, the average New Yorker paid a dime for a Coney Island hot dog.
Beginning this Wednesday, August 1st, enjoy your choice of hot dog, chips, and a drink for only $6! Good on all varieties for a limited time!
Be the first to know and let us send you an email when DEEN DOGS posts news and promotions. Your email address will not be used for any other purpose, and you can unsubscribe at any time.
Chicago Dog Combo Deal! Only $6! Begins this Wednesday, July 11th for a limited time!
Introducing our new regional style hot dogs to our menu, featuring favorite toppings from all over the globe! Beginning Wednesday, June 20th we will offer a different regional favorite, each for a limited time! Come and try our first feature - The Carolina Slaw Dog!
New Saturday Special begins this Saturday-limited time only!
It's what you've been waiting for, starting next week-our summer hours begin!
Check out our new Saturday special! For a limited time only!


Looking for something different to do for a birthday, hen or stag do?
What about booking a private workshop with us?
We can accommodate up to 14 people here at our store in Brixton, for bigger classes we suggest either we come to you or for you to book a private room of a nearby pub - just making sure they are happy with having a drawing workshop held there.
Drink and Draw swings into action with a variety of drawing games from Pictionary to blind drawing, getting everyone to enjoy releasing their inner artist. With the emphasis on speed rather than accuracy, it doesn't matter what level of drawing you have. You will then be introduced to the main event, from still life to vintage keys while being guided by our art teacher. You will get expert tips on shading, tone, composure and more so you build up your drawings step by step.
We tend to start with two games taking 20-30mins then do 3 sketches in charcoal using different techniques that the teacher will demonstrate. All paper, art materials and things to draw are be provided, all you need to bring is yourselves and whatever you would like to drink. The whole class takes 1.5hrs and we ask for 30 mins to prep the area before the class starts and suggest a 30mins tidy up at the end.
The price for a Drink and Draw is £295 for a standard size class of up to 14 people. For a bigger class the price becomes £20 per person. If you are keen to book a date just let us know the day you are ideally after and we'll check the availability of our teacher.
Once a date is set we ask for a £100 nonrefundable deposit to secure it. Unfortunately, should you need to change the date or cancel there is no refund of the deposit as we have already confirmed with our teacher.


Show up dressed to a network meeting in shorts and sandals and you just might lose prospective clients. You knew that, right? Something you might not know… A study published in 2006 conducted by Princeton psychologists revealed that it takes only a tenth of a second to form a first impression.
Another presented at the Society for Personality and Social Psychology in 2014 tells us we are not good at changing our opinions once formed. This can help to explain why, from a young age, we learn to follow basic rules of etiquette when meeting new people. It is all about making people like us within that first tenth of a second.
Ever since Emily Post was a thing, and even before then, there have been rules to help us appear attractive to others. We have hundreds of years of knowledge about polite behavior to draw on to create that great first impression when meeting someone face to face. But today, a good chunk of business takes place online. Ever measured what kind of impression your online presence is making?
What does your website say about you and your business? Here are three points to measure your website against. Along with some tips that will have your business be ready to meet one and all.
By some lucky stroke of fate, a prospective client sees your website URL and clicks on it. And waits… and waits… and leaves. How often have you abandoned a site for taking too long to load? According to KISSmetrics, loading time is one of the leading factors for abandoning a website.
How fast should it load? Akamai Technologies, Inc. says 2 seconds, based on a study they did in 2009. Chances are high that since this study, we have only become more impatient not less.
Is your site within an acceptable load speed range? Pingdom has a tool that allows you to measure website speed and provides a diagnostic test along with its test results.
The takeaway here is: No matter how much money you have spent on getting your site up, if it takes too long to load, you have an ineffective website.
Remember that study we mentioned earlier? Not yet convinced about how fickle we are about how things should look? Ask yourself if you would buy from (A) a sleek, effective website, or (B) a website using Comic Sans font in many different sizes. That flashes. On a patterned background. Not so much.
We like to say that looks don't matter when it comes to telling preteens how to pick their friends. "Personality is what counts," we say. But when it comes to websites, abandon that logic. The design of your website translates into its personality. No design (or poor design) = no personality = no attraction = no upswing in business.
"But my kid's best friend is a website genius! He designed this for me…" If your website has not obtained the results you want, consider hiring someone who does this as their life's work. Nothing beats professionals who know their business.
Ever been to a website and the next thing you knew you were signing up for their service? Guess what caused that? Persuasive words. Words that sold you on the product or service the site was about. Your buy might have appeared impulsive to you, but not so. Rather, it was a careful marketing strategy by someone who knew how to use words to their fullest advantage.
Another way in which words matter is SEO. For example, say you have a business and you want SEO that will help locals in Dallas, TX find you. Hiring a team that understands SEO and web design will take you to that next level.
Give your website and your business the greatest chance for success by adding persuasive copy, enhanced by SEO. If you can't do it yourself, hire someone who understands where you want to take your business. A good one is worth their weight in gold.
Online presence matters. Do not show up poorly dressed.


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Thread: Maximum R&B: The 'Orrible 'Oo
Susan Foreman
Location: Basil Fawlty country: The English Riviera
Maximum R&B: The 'Orrible 'Oo
Use this thread to discuss anything Who releated
Formed in 1964, and consisting of vocalist Roger Daltrey (b. 1944), guitarist Pete Townshend (b. 1945), bassist John Entwistle (b. 1944, d 2002) and drummer Keith Moon (b. 1946 2, 1978) the band became the faces of the fledgling mod movement - strange when you realise that each album release moved them further away from the R&B sound:
My Generation - R&B
A Quick One - Pop
The Who Sell Out - Psychedelia
Tommy - Hard rock
Who's Next - Progressive rock
Quadrophenia - Heavy metal
The Who By Numbers - Melancholia
Who Are You - Rock
They are as well known for their on (and off) stage antics as they are for their music: backstage fights, destroyed equipment, entries in the Guinness Book of Records as 'the world's loudest band', cars-in-swimming-pools, exploding toilets etc!
At time of writing, the surviving members of the band have just started their umpteenth 'farewell' tour, entitled 'Moving On'. For this, they are using a full symphony orchestra on stage with them
People try to put us down
Just because we get around
Golly, Gee! it's wrong to be so guilty
Send a private message to Susan Foreman
Find all posts by Susan Foreman


text:
This Is What A "Normal" Sex Life Looks Like
Hannah Witton On What A "Normal" Sex Life Looks Like
Jess Commons
For those not in the know, Hannah Witton is a YouTuber. A big one.
Hannah has nearly 350,000 subscribers on her YouTube channel and collectively, her videos have been watched nearly 29 million times. That's a lot of eyes on one 25-year-old from Manchester.
What makes Hannah worth checking out, though, is her dogged determination to educate younger generations about all the sex stuff we had to muddle our way through as teenagers. Things like period sex. Which, tbh, is something we could all do with a bit of education on, even now.
In 2016, Hannah was nominated as one of eight Girls Champions for the BBC's 100 Women list, thanks to her work on sexual education. She's been honest and open about contraception, given lessons on anatomy, and been frank about toxic relationships.
Want more proof? Hannah's new book Doing It: Let's Talk About Sex is the manual your sexually inexperienced teenage self was crying out for. Those of you old enough to remember magazines will recall desperately flipping the pages of Sugar, hoping to find a nugget of honest advice about "what to do if you had awkward sex with Liam from Maths in his big sister's bed after too many WKDs" in among the "wait for the right guys" and "check with your doctor firsts".
In Doing It, Hannah covers everything from masturbation ("It's truly magical!"), to sex shaming ("If I had 10p for every time I've been called a slut I could buy myself a luxury sex toy"), to the big, serious issues like consent and what a healthy relationship looks like.
Like the period sex video, there's also plenty in it for those of us that have been having sex for years. Do you know, for instance, the stories of how your best friends first discovered masturbation? How about how deaf people give sexual consent? There are even anatomical diagrams of the female reproductive system for you to peruse because, frankly, I'm not entirely sure many of us could label all the different parts and what they do correctly, now, could we?
"The most common question is always 'Am I normal?'" Hannah says when we ask what her viewers ask her the most. "Whatever it is... their sexual desires, their bodies... whatever they believe isn't normal and are ashamed of talking about."
The answer, she says reassuringly, is nearly always "Yes, you're normal."
I will sing this until the day I die! Everyone is different. The amount or type of sex you're having and who with is entirely your business.
As previously mentioned, masturbation is a key factor in her book. In fact she refers to it, rather wonderfully, as "self-care" – meaning you can now add it to your list of wellness requirements, directly under "yoga", "gym" and "eat lots of grains and whole foods".
"It has loads of health benefits!" she says. "Cleaner, healthier genitals" and, she reminds us, it can help with stress.
So why are some women still more reluctant to talk about masturbation as openly as they talk about their sex lives? "We're not taught about our bodies when we're younger," she explains. "We're not taught about the clitoris!" She continues: "What we are taught through society and culture, though, is that girls just aren't that sexual."
What she does think is super-important is schools providing the right kind of sexual education. "It ensures that everyone is getting the same information and no one is left behind in terms of their understanding of really important topics."
Really important topics like consent, for instance – to which Hannah dedicates an entire section of her book, on top of the chapter on porn and porn addiction, healthy relationships, and sex shaming. One misconception she still hears when it comes to consent is the idea that you can just "assume someone is into it".
"Never assume. Always ask" she reiterates firmly.
Overall, the main takeaway from her book is that, when it comes to sex, as long as you and your partner are both consenting and happy, there is no such thing as "normal".
"I will sing this until the day I die!" she says. "Everyone is different. The amount or type of sex you're having and who with is entirely your business."
She continues, "There is no right or wrong way to enjoy a healthy sex life, it's whatever works for you and the consenting partner or partners."
In short? "You do you, boo."
Doing It: Let's Talk About Sex by Hannah Witton is out now
Hannah Witton Sex Interview Consent Masturbation
Health • Sex
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A Dream business owner is committed and passionate with the desire to create more time and success for the client, make more money for themselves and enjoy life. Dreams can be difficult to attain, however, it is the pinnacle for a small business owner. With a plan, all business dreams can be attained.
Leveling is actually completed. Don't forget to determine the interconnection of all the plumbing and also drinking water outlines. Exchange all of the skirting that has been taken out round the camper.
Lay your t-shirt flat. Pinch the fabric at the center of the shirt between two of your fingers, making sure gather the back layer of fabric as well as the front.
drains backing up toilet bubbling are some of the common complications that homeowners face. The blocked drain affects the smooth operation of the household. Every activity that is related to the drainage system becomes impossible to carry out.
Learning rosetta it a lot more handy for you to be able to clean. Detroit has historically been a metropolis that supports the arts on many fronts. There are beautiful small and bigger award-winning hotels learning rosettaas well as other places to stay that are aimed at every budget level. You will also much like the reality that Pellet Stoves Inserts are straightforward to load.Stone and marble floors were great to unify -both essentially and in practice- living rooms with terraces and if polished perhaps even could reflect the exterior surroundings. You can find unlimited range of shades and tones that will be of your taste and will also go with the furniture inside your house.
Many people have had good results with making use of baking soda, vinegar and hot water to help keep plumbing pipes clean. This process operates in the same way as using a salt water solution in the way that it's more of a preventive measure. Pour a half cup of baking soda then a half cup of vinegar and then hot water to help keep drains gurgling showering clean and free of odors.
If you can prevent your jewelry from tarnishing, it will surely look much more attractive. Don't wear jewelry near water. A lot of metals will rust, tarnish or dull when they come in contact with water. To give jewelry an added layer of protection apply a thin layer of clear nail lacquer.
Any remodel job requires you to figure the approximate cost and double it. Old plumbing or wiring or wall board can bite your budget quickly both in money and in time. If you don't allow enough margin in your budget for a major overrun or two, you better stock up on your nitro pills and Maalox. You will need it.
One of the easiest ways to improve your heating and air condition system is to clean the air vents. You know the air vents are dirty when they look black. Dust the vents thoroughly. Check the vents occasionally because if they turn black quickly, there may be a bigger problem.


Intervals are a great way to improve both your cardiovascular efficiency and your speed and the great thing about them is you can do them in the pool, on your bike, or running. No special equipment is needed for them — all you need is what you normally would use for that particular activity.
In running, they are a great way to teach your legs to turn over more quickly, to help you push through that first blockade of pain, and show you that you CAN run faster. With that in mind, Jake and I set out for one of my favorite interval workouts on foot. Man how I love this workout.
From my house to a local middle school track is 2.0 miles. We ran this as a warm-up, staying between a 8:30-8:45 mile. This portion of your run should really be easy — all you want to do is get your muscles warmed up and your blood pumping. We got to the track in 17:10 and immediately started our workout. Our 5K goal pace is right around 6:30, so we targeted this pace as part of the track workout. We ran 4×400 repeats with an easy lap in between each set and after the last one as well. The easy laps were closer to a 10:30 pace, which was about right to get our heart rate calmed back down.
The intervals really got tougher and tougher. The first was at a 6:20 pace, the second at a 6:30 pace, the third at a 6:38 pace, and the last we decided we needed to speed it up. I would love to report that we pounded a 6:00 pace, but we only were able to get to a 6:20 pace. After the one lap jog, we started on the 2.0 miles home. It was a great workout and a good day.
Of course, we had a good stretching session at the end so as to hopefully improve flexibility. So if you are training for a triathlon, you have to get some intervals worked into your schedule. They hurt, and they stress your body like nothing else, but they will help you improve your speed.
Nice work on the intervals!
Great workout, I used to do 400s all the time in HS/ college( soo, soo many 400 and 800 repeats!), I haven't done them at a track since then. I do perform 1 min on 1 min off intervals which are close to this or sometimes 1 min on 2 min off if I really want to get the most out of the sprint.


An animated Wallpaper gif of Oleander in a witch/sorceress/enchantress costume with a cauldron and spirits flying out of of it one of the spirits is Fred and then he eventually turns into his physical form. After that the cauldron truns to another sinister colour with more deomonic spirits come out of the cauldron as more dark magic is being used for spells.
There could be a trick or treat version of this where Pom opens her bag of goodies from Halloween and Fred pops out the bag and scares Pom and her dogs.
Watch out for Killer Clown Cows tonight. " They're coming to get you".
I wouldn't be surprised if some of the scouts &/or predators start appearing on this forum tonight as Halloween night would have an effect on the lock keeping them in The Hold.
4 horned goat?? Love the look! Demonic goat, wonder if he knows Fred?
One can certainly ... try!
Almost as spooky as the fact that there is a SKELETON INSIDE YOU.
I'm pretty sure Halloween just overtook Christmas in my list of favorite holidays, all the stuff that everyone has been doing is fantastic.
EDIT: Whoever comments below shall be the 13th commenter, the ultimate number of spook.
I have the 13th comment on the halloween thread I am the spookiest!


text:
from swgpy.object import *

def create(kernel):
	result = Creature()

	result.template = "object/mobile/shared_gualama_patriarch.iff"
	result.attribute_template_id = 9
	result.stfName("monster_name","gualama")

	#### BEGIN MODIFICATIONS ####
	####  END MODIFICATIONS  ####

	return result

redpajama_set_name: RedPajamaGithub


The Gates Millennium Scholarship Program is part of the $1 billion Bill and Melinda Gates Foundation. Began in 1999, the foundation concentrates its support to talented racial minority groups with significant financial need.
If you are an academically talented student looking for scholarships for blacks, scholarships for minority women or Hispanic scholarships this may be well worth your time.
The actual award amount varies. After the financial aid amount is determined from your choice college winners can have their unmet cost of college (tuition, fees, books and living expenses) covered. Since this is often a large cost remaining for most students this is an attractive private scholarship to consider.
Financial need is 100% formula driven with Federal Pell Grant Federal Pell Grant eligibility required as well as your FAFSA being filed.
Finally, as with all private scholarships be very aware of filing deadlines.
The Gates Foundation is well known for it's analytical focus on a clearly defined social need. Their private scholarship program is no exception specifically targeting increasing the representation of racial minorities in specific fields.
Targeting mostly math and sciences be sure to visit the recommended scholarship link at the bottom of this page for the complete list of targeted disciplines.
Mirroring the success of Microsoft's rapid rise in the business world, the Gates Millennium Foundation also includes future leadership potential in it's screening process.
To back this level of commitment it also provides funding for post graduate work. The basis for its impressive graduation rate (87%) for its winning scholars can be traced back to a mentoring program throughout their students entire academic career.
While this private scholarship has the most specific criteria you can find along with very high above average awards, the bar is extremely high. Even if you feel you qualify for this award, be sure to hedge your bets by finding out a way to find attractive scholarship sources.
Visit my free webinar to learn how to use your time wisely in finding the most attractive sources of free financial aid.