text:
Events in Vonore
"Years ago, during the time when the whites were coming into this country, things were hard for the Cherokee…"
–Lloyd Sequoyah, 1978, from his testimony at hearings on the building of Tellico Dam
This legend foretells the survival of the Cherokee people, and so it is no surprise that it is located at Old Echota, one of the three original Cherokee mother towns, where the sacred fire burned. Although Old Echota and several Overhill towns have been submerged under Tellico Lake, as has the village of Tugaloo, the location of the sacred fire for the Lower Town; but the Cherokee people still survive and are preserving Kituwah, located in western North Carolina near the town of Cherokee.
Cherokee Heritage Trails in Tennessee bear a markedly different character from those in North Carolina. Because Tennessee has no contemporary Cherokee communities, the living Cherokee heritage is not well represented, although a number of venues offer works by Cherokee artists and crafts people, and periodically scheduled events present Cherokee performers. Neither is the eastern Tennessee landscape well represented in traditional Cherokee stories, many of which derive from the Eastern Band and focus on locales in the North Carolina mountains.
Sites in Vonore
Sequoyah Birthplace Museum
The Sequoyah Birthplace Museum provides an excellent interpretive overview of Overhill Cherokee history, culture, and archaeology, and visitors to the Cherokee Heritage Trail should consider the museum a prerequisite point of departure for touring the Overhill Cherokee landscape of eastern Tennessee.
The museum, owned and operated by the Eastern Band of Cherokee Indians, is situated on the south end of a 500-acre island created by Tellico Lake. In addition to the museum, the 47-acre complex includes a 300-seat amphitheater, a seven-sided open air pavilion, and picnic tables for visitors' use. From the museum, a 150-yard pathway leads southwest across a field to a grassy mound that serves as a mausoleum for the remains of Cherokees exhumed from the town sites excavated for Tellico Lake; visitors may pay their respects to generations of Cherokees who lived and died in the lower Little Tennessee River Valley.
Contact information: The Sequoyah Birthplace Museum
576 TN-360
Vonore, TN 37885
Website: www.sequoyahmuseum.org
Fort Loudoun State Historic Park
"The great King George has ordered his children, the Cherokees, and the English to love each other as Brothers and to live together as one people…"
— Capt. Raymond Demere, commander of Fort Loudoun, 1757
After leaving the Sequoyah Birthplace Museum, visitors should tour nearby Fort Loudoun State Historic Park to become further acquainted with Anglo-Cherokee relations, diplomacy, and trade in the mid-eighteenth century. The state park, which fronts on the former Little Tennessee River channel, shares Great Island with Sequoyah Birthplace Museum, and is located approximately one mile to the northeast. The park features a reconstruction of Fort Loudoun, a state-maintained visitor's center with well developed interpretive exhibits, walking trails, a large picnic area, and access to Tellico Lake.
Fort Loudoun (1756–1760), the first British military outpost west of the southern Appalachians, was founded at the request of pro-British Cherokee factions at Chota, who needed the fort and garrison to deter raiding on the Overhill towns by French allied Indians, to regulate trade and police unscrupulous traders, and to discourage French sentiment in some Overhill towns. The British considered the fort a much needed outpost against the French and "a strong curb upon the Upper Cherokees." Although relations between the Overhill Cherokees and the South Carolina colonial troops were initially amicable, the situation gradually deteriorated, and the Cherokees laid siege to the fort at the outset of the Anglo-Cherokee War of 1760–61. The garrison surrendered after a long siege, under terms that allowed their return to South Carolina, but Cherokee warriors ambushed the garrison about 15 miles south of the fort, killing 25 men in retaliation for the earlier killing of Cherokee hostages at Fort Prince George. After the surrender, the Cherokee warriors sacked the fort, and a number of Cherokee families moved in. When they abandoned the grounds after nearly a year, local Cherokees burned the fort, a reminder of the British military presence in their heartland.
Contact: Fort Loudoun State Historic Area
338 Fort Loudoun Road
Tellico Blockhouse
Across the lake from Fort Loudoun is the site of Tellico Blockhouse, a fort built in 1794 by the U.S. government to preserve the fragile peace between the Cherokees and white Americans. Stone foundations of fort building exposed by archaeological investigations during the 1970s have been stabilized for public visitation and the former wooden fortification walls are now represented by a low enclosure of corseted pilings. Interpretive exhibits interspersed among these ruins tell the story of the Tellico Blockhouse and its role maintaining order along the Cherokee frontier and promoting the "civilization" policy of the U.S. government. Visitors to the site can wander among the foundations and look across the river toward the old Cherokee Nation.
From 1794 until 1806, Federal troops garrisoned at the Tellico Blockhouse guarded the northern Cherokee frontier against encroachment and attack by local white militia and posses. It was here at Tellico Blockhouse that the federal government initiated its new "civilization" program among the Cherokees, a plan to pacify Indian nations by transforming them into communities of yeoman farmers. Agents like Silas Dinsmoor and Return J. Meigs proffered farming equipment, spinning wheels, looms, and other goods to Cherokees throughout the nation, disbursing such wares from their office and warehouse at Tellico Blockhouse. The government also established a trading factory at Tellico, a store that provided goods to Cherokee customers at cost, a policy designed to wean the Cherokees from their trade with the British. Tellico Blockhouse also became a gateway into the Cherokee Nation; all travelers had to stop there to apply to the agent for passports before entering tribal lands. Visitors at Tellico included Louis-Philippe, the future king of France, and Moravian missionaries David Steiner and Abraham deSchweinitz (1799).
Contact: Superintendents Office
Fort Loudoun State Historic Area
Sites Near Vonore
Chota and Tanasi (Memorial sites)
To reach the next town sites, Chota and Tanasi, continue southeast along TN 360 to the intersection with Pine Rd. (Monroe County Road 455) at Ballplay Creek, then travel Piney Flat Road (which becomes Rocky Hollow Road but remains County Road 455) southeast 6.8 miles to Bacon Ferry Road, a gravel road with signs directing visitors to the Chota and Tanasi memorials. Turn left on Bacon Ferry Road, which skirts the bend in the Little Tennessee River that was once home to Chota and Tanasi. The road passes the Tanasi memorial (at .8 miles) and ends in a cul-de-sac with parking lot at the pedestrian trail head to reach the Chota memorial.
Throughout much of the eighteenth century, the Overhill towns of Tanasi and, later, Chota, were recognized as "capitals" of the entire Cherokee Nation, beloved towns where Cherokees from all over the nation gathered for important national councils and religious events. The settlements were adjacent, and their intertwined history is complex. Tanasi (also written Tannassee, Tennessee, Tunasse, Tanassee, Tannassy, Tannassie, and Tennisse), which lends its name to the state and river, preceded Chota by decades as the Mother Town of the Overhill settlements and acknowledged capital of the nation. British colonial diplomats, like Col. George Chicken (1725) and Sir Alexander Cuming (1730), sought out Tanasi as the venue for negotiations with the tribe as a whole. On his mission to Overhill towns, Cuming obtained the "Crown of Tannassy, as an Emblem of universal Sovereignty over the whole Cherokee Nation," along with three eagle tails and four scalps to present to King George II. as a purported gesture of Cherokee allegiance.
P.O. Box 69, Citico Road
Frank H. McClung Museum
A brief, 45-minute drive northeast from Vonore on brings visitors to the regional center of Knoxville, where the Frank H. McClung Museum on the University of Tennessee campus features a new, permanent exhibition, Archaeology and the Native Peoples of Tennessee. This state-of-the art, comprehensive exhibition showcases 65 years of archaeological research by the University of Tennessee, and presents a detailed chronicle of native life in Tennessee (primarily eastern Tennessee) from the end of the Ice Age to modern times. The 3,200-square-foot exhibit hall is dominated by dramatic, life-sized murals by famed muralist Greg Harlin; these vignettes depict native life during the Paleo-Indian, Archaic, Woodland, Mississippian, and historic era Cherokee culture periods. The exhibits combine artifacts, images, and text to examine the changing lifeways of native peoples. The exhibit space is multi-tiered, with ramps and platforms defining different themes. Glass covered cases at floor level recreate excavated archaeological contexts such as a rock-filled fire hearth and an Archaic period dog burial. Pull-out study drawers allow visitors to learn more about particular types of artifacts and topics such as plant domestication, cave art, and mound building. A scale model of the 600-year-old village of Toqua can be explored with a fiber optic key. An education area in the center of the gallery presents five hands-on interactive exhibits where visitors can learn more about archaeology. This open space is also used in docent-led school group instruction.
The archaeological collections of McClung Museum are renowned, and the new exhibit features some of the most impressive examples of native art and craftsmanship in the eastern United States. The engraved shell gorgets, copper work, elaborate tobacco pipes, effigy vessels, and sandstone statues are fascinating for their aesthetic value as well as their cultural meanings. The Duck River cache of eccentric chipped stone objects from the Mississippian period and a 32.5-foot-long dugout canoe dating to 1797 are particularly noteworthy.
Contact: Frank H. McClung Museum
Website: www.mcclungmuseum.utk.edu
Treaty of Holston Park
While in Knoxville, visit the site of the Treaty of Holston Park on the newly developed Knoxville Riverfront on the Tennessee River, a place the Cherokees once knew as Kuwohi, the Mulberry Place. Here, a new statue commemorates the 1791 signing of the Treaty of Holston between the Cherokee Nation and the United States government, an agreement that laid the foundation for relations between the Cherokees and the new federal government. This landmark treaty established the "civilization" program, an early federal policy for pacifying hostile tribes by encouraging farming and settled life.
The treaty ceded a large tract of Cherokee land (including present-day Knoxville) and was generally disadvantageous to the Cherokees, who felt that they had been duped by Governor William Blount, whom they knew as "The Dirt Captain." The agreement barely stemmed white encroachment on Cherokee land; frontier violence between whites and Cherokees continued unabated, and a lasting peace was not concluded for three more years.
Contact: Public Affairs Office
City-County Building
Overhill Towns Driving Loop
After visiting the Sequoyah Birthplace Museum and Fort Loudoun, heritage trail guests are invited to tour the landscapes of the Overhill country by driving a 75-mile circuit that skirts many of the old town sites in the Little Tennessee, Tellico, and Hiwassee river valleys. This driving tour is designed to follow eighteenth century trails as closely as possible, routing visitors through the same hills and valleys that Attakullakulla, Oconostota, Nancy Ward, and thousands of other Overhill Cherokees traversed in their daily lives. Although the Anglo-American occupants of this landscape have wrought many changes over the past 180 years, much of the countryside retains a very rural character that harkens back to the heyday of the Overhill Cherokees and invites travelers to see the land as wayfarers did in the eighteenth century.
The complete circuit, from Vonore to the Hiwassee River and back, requires about two and a half hours of driving; this tour can be cut short at several junctures with access points to major highways. Many of the sites in this tour are located on private lands; these invite roadside viewing but not physical access. Most of the locations are currently unmarked and have no on-site interpretation, but their settings speak volumes about the Overhill world.
The Unicoi Turnpike Trail
"I left Fort Butler on the 19th in charge of 800 Cherokees. I had not an officer along to assist me, and only my own company as a guard…"
— Capt. L.B. Webster, June 28, 1838.
Just as our modern communities, states, and regions are integrated by the interstate highway system, the old Cherokee Nation was interconnected by a network of trails that linked town settlements. For Cherokee villages, these foot trails were conduits to the outside world; people, goods, and information moved constantly over the trail system. In traveling the Cherokee Heritage Trail, visitors follow many ancient pathways that have been supplanted by modern roads. Seldom are these native paths discernible; recent development and road building have obliterated all vestiges of most Cherokee trails. However, much of the Unicoi Turnpike path, one of the main arteries of the Cherokee trail system, can still be retraced across southeastern Tennessee, southwestern North Carolina, and northeastern Georgia. Major segments of this trans-Appalachian route, which was developed as a commercial wagon road in the early nineteenth century, survive intact on national forest lands, and can be experienced by driving and hiking between the heritage trail interpretive hubs at Vonore, Tennessee, and Murphy, North Carolina.
During the eighteenth century, British travelers referred to the Unicoi Turnpike route as the "Tellico Path," the "Overhill Trading Path," or simply, the "great trading path." This ancient route spanned the Cherokee Nation, connecting the Lower Towns in the foothills of South Carolina and Georgia with the Overhill settlements of eastern Tennessee. European traders, soldiers, and diplomats from the Carolina coast who plied this path entered the Cherokee back country along the north side of the Savannah River in South Carolina. The northern branch of the trail passed through the Lower towns of Keowee (now Lake Keowee, S.C.) and Oconee, crossed Oconee Mountain, and passed through Chattooga Town (where U.S. Highway 28 crosses Chattooga River). From the Chattooga River, the trail ascended Warwoman Creek, then descended Tuckaleechee Creek to Stecoah Old Town, near present-day Clayton, Georgia. Here, the path was joined by a southern branch, which ran through the Lower towns of Tugalo (now Lake Hartwell, near Toccoa, Georgia) and Tallulah to Stecoah. The area around Clayton is still known as "The Dividings," a place where paths join and diverge.
Contact information: Tennessee Overhill Heritage Association
L & N Depot
Etowah, TN 37331


If you ever saw the interior part of a plant, the one inside the flower where the pollen grains fall when the busy bees come looking for food, then you can imagine what this Pistillino Lamp looks like. I am not sure if "pestle" is translated "pistillino" in Italian, but the lamp surely looks like one. It has a nice and shiny chrome light bulb in the centre and many other smaller chrome spheres around it that are used to reflect light all over the place.
Even if this beautiful lamp seems very cool and modern, it was actually created by Studio Tetrarch in 1969. Well, the material used is chrome plated plastic and this does give away the period when the lamp was designed, but this Italian icon of the 20th century is still a very nice and modern accessory for your living room or maybe for your desk if you ever think about turning it into a desk lamp. You can purchase it now for just $299.


It is this time of the year when juicy fresh cranberries are everywhere and we can enjoy them as much as possible!
Start with this 3 steps recipe below for freshly made cranberry sauce.
Check out some ideas to use this fruity deliciousness and discover your own.
Add different spices for a new twist along the way with our spice recommendation in the recipe below.
Give a year of dinner with freshly ground spices.
Popular recipes from around the world with freshly ground spices.
Freshly made cranberry sauce is much more delicious than from a can, and it takes no effort with this 3-steps-recipe.
In a small POT, add cranberries and 1/2 cup water.
Bring to boil. Cook over low heat for 10-15 minutes.
Stir in 1-2 tbsp orange juice and agave syrup or honey until it tastes as you prefer it.
How about a new taste for your cranberry sauce?
Try one or two of the following spices.


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Paula Goncalves da Silva
Home/Paula Goncalves da Silva
Known as "Magic Paula" in her homeland for the offensive prowess she displayed while playing on Brazilian National Teams for 22 years
Played on her first national team at the age of 14
A two-time Olympian, helping Brazil earn a silver medal in 1996 in Atlanta after finishing 7 th in 1992 in Barcelona
Averaged 22 ppg on Brazilian National Team that captured the gold medal at 1994 World Championships
Played in six World Championships altogether from 1979 through 1998
Collected three Pan American Games medals, claiming a gold in 1991, a silver in 1987, and a bronze in 1983
Played on five teams that won South American Championship titles

redpajama_set_name: RedPajamaCommonCrawl


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Is Hydrogen Water Actually Good For You?
TIME Health
For more, visit TIME Health.
By now, the science is clear: The healthiest beverage you can drink is water. It's free of sugar, salt and chemicals that can harm and age cells, as long as it's filtered properly.
If H2O is so good for you, then boosting the hydrogen content should make it even healthier—right? That's what more and more beverage companies are banking on. So-called "hydrogen water"—water into which hydrogen gas is dissolved—is increasingly popular. A handful of companies are now selling $3 bottles of the stuff, while others are pushing tablets that you can dissolve into your water to boost its hydrogen content. Plenty more are peddling machines that cost more than $1,000 for people who want to gas up their own home versions. That's all for water that likely won't taste or look any different from what comes out of the tap.
Some of these companies claim that adding more hydrogen to water increases energy, improves recovery after a workout and reduces inflammation, making regular water look like a downright underachiever.
But the science behind those claims is weak, backed only by a few encouraging studies in rats and mice and even fewer—and smaller—trials in people.
Why Your Bottled Water Contains Four Different Ingredients
Dr. Nicholas Perricone, who sells what he calls a natural antioxidant "energy recovery drink" called Dr. Perricone Hydrogen Water for about $3 a can, admits that it's not yet known exactly how added hydrogen in water potentially works on the body. Animal studies and the few human studies that have been conducted, mostly in Japan, suggest that it may work as an antioxidant and to reduce inflammation. Oxidative stress from the sun, normal body processes and exposure to pollutants can damage cells and lead to premature aging and diseases like cancer. Inflammation also contributes to many chronic conditions, from type 2 diabetes to heart problems and brain disorders. Hydrogen appears to reduce both. That means, at least in theory, that hydrogen water could help to reduce everything from diabetes to hardening of the heart vessels to Alzheimer's and cancer. The studies to prove whether that's the case, however, haven't been conducted.
In the U.S., the hydrogen craze is mostly limited to water, and the claims are all over the map. Perricone focuses his on hydrogen's effect on energy, which is based on his own small study of 20 people. He measured energy changes in skin cells after people drank 16 ounces of Dr. Perricone Hydrogen Water and found that people who drank it seemed to have increased activity in the enzymes responsible for producing energy in the cells. (But any water would do that.)
That was enough to convince him to study hydrogen water for its ability to improve energy, which he says may affect not only muscle but the brain as well. "I don't see any downside to drinking hydrogen water," he says. "It's nontoxic, it's not expensive." He also views it as an alternative to energy drinks.
Does Pink Himalayan Salt Have Any Health Benefits?
Still, why not? isn't a compelling enough reason to buy a drink trumpeting health claims. For one, it's not clear how much hydrogen is needed to have therapeutic benefits and how much water you'd have to drink to reap the potential rewards. "We don't know anything about dosing or the frequency you need to drink hydrogen water to get health benefits," says Robin Foroutan, a dietitian and spokesperson for the Academy of Nutrition and Dietetics. The amounts of hydrogen in the various products currently on the shelves vary widely, and there is no regulation to standardize formulas—mainly because there isn't a solid scientific base to determine how much is needed to affect various conditions. Perricone says that the packaging for the water is also important, since hydrogen tends to dissipate very quickly and can diffuse through plastic and glass. Any products in these containers won't likely have much added hydrogen in them, he says. (Perricone says he sells his water packed in a special aluminum coated with a proprietary compound to maintain hydrogen's efficacy.)
"The bottom line is we are not sure, and we don't know yet how helpful it can be for health," says Foroutan. "It doesn't seem like something that is risky to try. But we need more research."


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//@HEADER
// ***************************************************
//
// HPCG: High Performance Conjugate Gradient Benchmark
//
// Contact:
// Michael A. Heroux ( maherou@sandia.gov)
// Jack Dongarra     (dongarra@eecs.utk.edu)
// Piotr Luszczek    (luszczek@eecs.utk.edu)
//
// ***************************************************
//@HEADER

/*!
 @file ComputeSPMV.cpp

 HPCG routine
 */

#include <iostream>

#include "ComputeSPMV.hpp"
#include "ComputeSPMV_ref.hpp"
#include "TxVectorOptimizationDataBase.hpp"
#include "TxMatrixOptimizationDataBase.hpp"

/*!
  Routine to compute sparse matrix vector product y = Ax where:
  Precondition: First call exchange_externals to get off-processor values of x

  This routine calls the reference SpMV implementation by default, but
  can be replaced by a custom, optimized routine suited for
  the target system.

  @param[in]  A the known system matrix
  @param[in]  x the known vector
  @param[out] y the On exit contains the result: Ax.

  @return returns 0 upon success and non-zero otherwise

  @see ComputeSPMV_ref
*/
int ComputeSPMV(const SparseMatrix& A, Vector& x, Vector& y, bool copyIn, bool copyOut) {
  TxMatrixOptimizationDataBase* optData =
      (TxMatrixOptimizationDataBase*)A.optimizationData;
  return optData->ComputeSPMV(A, x, y, copyIn, copyOut);
}

redpajama_set_name: RedPajamaGithub


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Brain delivery of a potent opioid receptor agonist, biphalin during ischemic stroke: Role of organic anion transporting polypeptide (OATP)
Thamer H. Albekairi, Bhuvaneshwar Vaidya, Ronak Patel, Saeideh Nozohouri, Heidi Villalba, Yong Zhang, Yeon Sun Lee, Abraham Al-Ahmad, Thomas J. Abbruscato
Transporters (expressed) at the blood-brain barrier (BBB) can play an essential role in the treatment of brain injury by transporting neuroprotective substance to the central nervous system. The goal of this study was to understand the role of organic anion transporting polypeptide (OATP1; OATP1A2 in humans and oatp1a4 in rodents) in the transport of a potent opioid receptor agonist, biphalin, across the BBB during ischemic stroke. Brain microvascular endothelial cells (BMECs) that were differentiated from human induced pluripotent stem cells (iPSCs) were used in the present study. The effect of oxygen-glucose deprivation (OGD) and reperfusion on the OATP1 expression, uptake, and transport of biphalin was measured in induced pluripotent stem cells differentiated brain microvascular endothelial cells (iPSC-BMECs) in the presence and absence of an OATP1 substrate, estrone-3-sulfate (E3S). Biphalin brain permeability was quantified while using a highly sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method. It was found that iPSC-BMECs expressed OATP1. In vitro studies showed that biphalin BBB uptake and transport decreased in the presence of an OATP1 specific substrate. It was also observed that OGD and reperfusion modulate the expression and function of OATP1 in BMECs. This study strongly demonstrates that OATP1 contributes to the transport of biphalin across the BBB and increased expression of OATP1 during OGD-reperfusion could provide a novel target for improving ischemic brain drug delivery of biphalin or other potential neurotherapeutics that have affinity to this BBB transporter.
https://doi.org/10.3390/pharmaceutics11090467
Biphalin
Organic anion transporting polypeptide
Transport mechanism
10.3390/pharmaceutics11090467
Dive into the research topics of 'Brain delivery of a potent opioid receptor agonist, biphalin during ischemic stroke: Role of organic anion transporting polypeptide (OATP)'. Together they form a unique fingerprint.
biphalin Medicine & Life Sciences 100%
Organic Anion Chemical Compounds 61%
Opioid Receptors Medicine & Life Sciences 54%
Agent Interacting With Transmitter, Hormone or Drug Receptor Chemical Compounds 54%
Estrone 3-Sulfate Chemical Compounds 44%
Polypeptide Chemical Compounds 40%
Blood-Brain Barrier Medicine & Life Sciences 39%
Albekairi, T. H., Vaidya, B., Patel, R., Nozohouri, S., Villalba, H., Zhang, Y., Lee, Y. S., Al-Ahmad, A., & Abbruscato, T. J. (2019). Brain delivery of a potent opioid receptor agonist, biphalin during ischemic stroke: Role of organic anion transporting polypeptide (OATP). Pharmaceutics, 11(9), [467]. https://doi.org/10.3390/pharmaceutics11090467
Brain delivery of a potent opioid receptor agonist, biphalin during ischemic stroke : Role of organic anion transporting polypeptide (OATP). / Albekairi, Thamer H.; Vaidya, Bhuvaneshwar; Patel, Ronak et al.
In: Pharmaceutics, Vol. 11, No. 9, 467, 09.2019.
Albekairi, TH, Vaidya, B, Patel, R, Nozohouri, S, Villalba, H, Zhang, Y, Lee, YS, Al-Ahmad, A & Abbruscato, TJ 2019, 'Brain delivery of a potent opioid receptor agonist, biphalin during ischemic stroke: Role of organic anion transporting polypeptide (OATP)', Pharmaceutics, vol. 11, no. 9, 467. https://doi.org/10.3390/pharmaceutics11090467
Albekairi TH, Vaidya B, Patel R, Nozohouri S, Villalba H, Zhang Y et al. Brain delivery of a potent opioid receptor agonist, biphalin during ischemic stroke: Role of organic anion transporting polypeptide (OATP). Pharmaceutics. 2019 Sep;11(9):467. doi: 10.3390/pharmaceutics11090467
Albekairi, Thamer H. ; Vaidya, Bhuvaneshwar ; Patel, Ronak et al. / Brain delivery of a potent opioid receptor agonist, biphalin during ischemic stroke : Role of organic anion transporting polypeptide (OATP). In: Pharmaceutics. 2019 ; Vol. 11, No. 9.
@article{fc2118763cb04e19a98ab9a8f81d7f54,
title = "Brain delivery of a potent opioid receptor agonist, biphalin during ischemic stroke: Role of organic anion transporting polypeptide (OATP)",
abstract = "Transporters (expressed) at the blood-brain barrier (BBB) can play an essential role in the treatment of brain injury by transporting neuroprotective substance to the central nervous system. The goal of this study was to understand the role of organic anion transporting polypeptide (OATP1; OATP1A2 in humans and oatp1a4 in rodents) in the transport of a potent opioid receptor agonist, biphalin, across the BBB during ischemic stroke. Brain microvascular endothelial cells (BMECs) that were differentiated from human induced pluripotent stem cells (iPSCs) were used in the present study. The effect of oxygen-glucose deprivation (OGD) and reperfusion on the OATP1 expression, uptake, and transport of biphalin was measured in induced pluripotent stem cells differentiated brain microvascular endothelial cells (iPSC-BMECs) in the presence and absence of an OATP1 substrate, estrone-3-sulfate (E3S). Biphalin brain permeability was quantified while using a highly sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method. It was found that iPSC-BMECs expressed OATP1. In vitro studies showed that biphalin BBB uptake and transport decreased in the presence of an OATP1 specific substrate. It was also observed that OGD and reperfusion modulate the expression and function of OATP1 in BMECs. This study strongly demonstrates that OATP1 contributes to the transport of biphalin across the BBB and increased expression of OATP1 during OGD-reperfusion could provide a novel target for improving ischemic brain drug delivery of biphalin or other potential neurotherapeutics that have affinity to this BBB transporter.",
keywords = "Biphalin, Blood-brain barrier, Ischemic stroke, Organic anion transporting polypeptide, Transport mechanism",
author = "Albekairi, {Thamer H.} and Bhuvaneshwar Vaidya and Ronak Patel and Saeideh Nozohouri and Heidi Villalba and Yong Zhang and Lee, {Yeon Sun} and Abraham Al-Ahmad and Abbruscato, {Thomas J.}",
note = "Funding Information: Funding: This research was funded partially by start-up funding from the Blood-Brain Barrier Research Center (T.J.A.) and a research enhancement grant from the Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center School of Pharmacy, Amarillo, TX (B.V.). Publisher Copyright: {\textcopyright} 2019 by the authors. Licensee MDPI, Basel, Switzerland.",
doi = "10.3390/pharmaceutics11090467",
journal = "Pharmaceutics",
T1 - Brain delivery of a potent opioid receptor agonist, biphalin during ischemic stroke
T2 - Role of organic anion transporting polypeptide (OATP)
AU - Albekairi, Thamer H.
AU - Vaidya, Bhuvaneshwar
AU - Patel, Ronak
AU - Nozohouri, Saeideh
AU - Villalba, Heidi
AU - Zhang, Yong
AU - Lee, Yeon Sun
AU - Al-Ahmad, Abraham
AU - Abbruscato, Thomas J.
N1 - Funding Information: Funding: This research was funded partially by start-up funding from the Blood-Brain Barrier Research Center (T.J.A.) and a research enhancement grant from the Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center School of Pharmacy, Amarillo, TX (B.V.). Publisher Copyright: © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
N2 - Transporters (expressed) at the blood-brain barrier (BBB) can play an essential role in the treatment of brain injury by transporting neuroprotective substance to the central nervous system. The goal of this study was to understand the role of organic anion transporting polypeptide (OATP1; OATP1A2 in humans and oatp1a4 in rodents) in the transport of a potent opioid receptor agonist, biphalin, across the BBB during ischemic stroke. Brain microvascular endothelial cells (BMECs) that were differentiated from human induced pluripotent stem cells (iPSCs) were used in the present study. The effect of oxygen-glucose deprivation (OGD) and reperfusion on the OATP1 expression, uptake, and transport of biphalin was measured in induced pluripotent stem cells differentiated brain microvascular endothelial cells (iPSC-BMECs) in the presence and absence of an OATP1 substrate, estrone-3-sulfate (E3S). Biphalin brain permeability was quantified while using a highly sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method. It was found that iPSC-BMECs expressed OATP1. In vitro studies showed that biphalin BBB uptake and transport decreased in the presence of an OATP1 specific substrate. It was also observed that OGD and reperfusion modulate the expression and function of OATP1 in BMECs. This study strongly demonstrates that OATP1 contributes to the transport of biphalin across the BBB and increased expression of OATP1 during OGD-reperfusion could provide a novel target for improving ischemic brain drug delivery of biphalin or other potential neurotherapeutics that have affinity to this BBB transporter.
AB - Transporters (expressed) at the blood-brain barrier (BBB) can play an essential role in the treatment of brain injury by transporting neuroprotective substance to the central nervous system. The goal of this study was to understand the role of organic anion transporting polypeptide (OATP1; OATP1A2 in humans and oatp1a4 in rodents) in the transport of a potent opioid receptor agonist, biphalin, across the BBB during ischemic stroke. Brain microvascular endothelial cells (BMECs) that were differentiated from human induced pluripotent stem cells (iPSCs) were used in the present study. The effect of oxygen-glucose deprivation (OGD) and reperfusion on the OATP1 expression, uptake, and transport of biphalin was measured in induced pluripotent stem cells differentiated brain microvascular endothelial cells (iPSC-BMECs) in the presence and absence of an OATP1 substrate, estrone-3-sulfate (E3S). Biphalin brain permeability was quantified while using a highly sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method. It was found that iPSC-BMECs expressed OATP1. In vitro studies showed that biphalin BBB uptake and transport decreased in the presence of an OATP1 specific substrate. It was also observed that OGD and reperfusion modulate the expression and function of OATP1 in BMECs. This study strongly demonstrates that OATP1 contributes to the transport of biphalin across the BBB and increased expression of OATP1 during OGD-reperfusion could provide a novel target for improving ischemic brain drug delivery of biphalin or other potential neurotherapeutics that have affinity to this BBB transporter.
KW - Biphalin
KW - Blood-brain barrier
KW - Ischemic stroke
KW - Organic anion transporting polypeptide
KW - Transport mechanism
U2 - 10.3390/pharmaceutics11090467
DO - 10.3390/pharmaceutics11090467
JO - Pharmaceutics
JF - Pharmaceutics


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Q: Arriving at the formula for expected value of a random variable I was trying to solve this programming problem but I can't solve it since I am not able to arrive at the right formula for it. I dont want the solution using Dynamic Programming. I just want someone to explain how to get the formula for answering that question. This is not a homework problem. Thanks for helping me.

A: This is a queuing problem with a binomial twist. Wikipedia has some good information about the Binomial Distribution. From this page, we know that the probability of getting exactly $k$ successes in $n$ trials when the probability of success is $p$ is:
$${n \choose k}p^k(1-p)^{n-k}$$
Now, let's assume that $n$ people stand in the queue for the escalator. At each second one of the two following possibilities takes place: either the first person in the queue enters the escalator with probability $p$, or the first person in the queue doesn't move with probability $(1 - p)$, paralyzed by his fear of escalators and making the whole queue wait behind him.
The expected number of people on the escalator after $t$ seconds, then, is:
$$\sum_{x=1}^{\text{min}(n,t)}x \cdot \text{probabilty of $x$ people on the escalator} = \sum_{x=1}^{\text{min}(n,t)} x \cdot {t \choose x}p^x(1-p)^{t-x}$$
Where:
$${t \choose x} = \frac{t!}{x!(t-x)!}$$
Each term in the summation multiplies the probability of $x$ people being on the escalator by $x$. We only sum over the range $1$ to $\text{min}(n,t)$ because once everyone in the queue has been called, no one else can get on the escalator. Similarly, once time $t$ is reached, we are not interested in anyone else who is getting on the escalator.
Of course, this all assumes that the escalator is infinitely long and that no one gets off of it at some later time.

A: It appears that once you reach a person who is scared of the escalator, then no more people enter...forever. Thus, after $t$ seconds (assume $t$ is integer valued), one of two events can happen:

*

*A person with no fear is at the head of the line, call this $N_t$

*A scared person is at the head of the line, call this $F_t$

$N_t$ can only happen if every person up to time $t$ got on the escalator, so:
$$P(N_t)=p^t$$
$F_t$ will happen the if we encountered a scared person at some point up to time $t$, which is equal to $N_t^c$.
$$P(F_t)=1-P(N_t)=1-p^t$$
Now, given $F_t$, the let $T_t$ be the number of people who got on the elevator before the the scared person moved to the head of the line (which we know occurred in the $t$ intervals before time $t$):
$$P(T_t=a)=p^{a}(1-p)\text{ for }0\leq a\leq t,\text{ and } 0\;o.w.$$
This is just an (unnormalized) conditional geometric distribution with parameter $q:=1-p$
Since $T_t$ is a positive random variable, we can exploit a nice trick for getting the expected value:
$$E[T_t]=\frac{\sum_{i=1}^{t} P(T_t\geq i)}{1-p^{t}}=\frac{\sum_{i=1}^{t} p^i }{1-p^{t}}=\frac{\sum_{i=0}^{t} p^i -1}{1-p^{t}}=\frac{\left(\frac{1-p^{t}}{1-p}\right)-1}{1-p^{t}}=\frac{p-p^{t}}{(1-p)(1-p^{t})}$$
So, we now combine our two results:
The expected number of people on the escalator at time $t$, $Z_t$, is the probability that the person at the head of the line at time $t$ is not scared times $(t)$ (since everyone got on up to this point), plus the the probability that a scared person is at the head of the line at time $t$ times the expected value of the number of people on the escalator given we have a scared person at the head of the line at time $t$ (our second result):
$$E[Z_t]=tp^t+(1-p^t)\left(\frac{p-p^{t}}{(1-p)(1-p^{t})}\right) \;\;\;\;\square$$

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El Paso author Ron Stallworth named grand marshal of Sun Bowl Parade
Trish Long
The Oscar Leeser Hyundai of El Paso Sun Bowl Parade will feature El Paso author Ron Stallworth as the grand marshal on Nov. 28, Thanksgiving Day.
The movie "BlacKkKlansman," based on a book by Stallworth and directed by Spike Lee, won the Academy Award for Best Adapted Screenplay on Feb. 24.
The film was based on Stallworth's memoir, "Black Klansman," about his time as a Colorado Springs police officer who infiltrated the KKK. The screenplay also was credited to Charlie Wachtel, David Rabinowitz and regular Lee collaborator Kevin Willmott.
The crowd applauded as presenter Samuel L. Jackson announced the win, and Stallworth joined Lee and the other credited writers on the stage to accept the award.
Here is a look back at past grand marshals.
• Jan. 1, 1936: Capt. John R. Hughes, veteran state law enforcement officer, former Texas Ranger.
• Jan. 1, 1937: Lucile Browne, Hollywood actress
• Jan. 1, 1938: Miss Noel Collier, local actress and great granddaughter of Buck Kilgore, U.S. senator
More:Oscar Leeser's Hyundai of El Paso sponsors Sun Bowl Thanksgiving parade
• Jan. 1, 1939: Neill McKay, representing Utah, granddaughter of Brigham Young
• Jan. 1, 1940: Kathryn Jones, daughter of Arizona Gov. Robert Taylor Jones
• Jan. 1, 1941: Joseph Bentonelli, American lyric tenor
• Jan. 1, 1942: Capt. John R. Hughes, veteran state law enforcement officer, former Texas Ranger
• 1943-1946: No parade
• Jan 1, 1947: Sam D. Myres, a saddle-maker who made saddles for ranchers and Hollywood stars such as Gene Autry and John Wayne.
• Jan 1, 1948: Anna Louise Jagoe, 1946-47 Sun Queen
• Jan 1, 1949: Col. Ray N. Lewis, deputy post commander Fort Bliss
• Jan 1, 1950: Maj. Gen. John L. Homer, commander Fort Bliss
• Jan. 1, 1951: Maj. Gen. John T. Lewis, commander Fort Bliss
• Jan. 1, 1952: Dr. C.M. Hendricks, originator of the Sun Carnival
• Jan. 1, 1953: Karl O. Wyler, owner of KTSM television and radio stations
• Jan. 1, 1954: New Mexico Gov. Edwin L. Mechem
• Jan. 1, 1955: Maj. Gen. Paul W. Rutledge, commander of Fort Bliss, and Mrs. Rutledge
• Jan. 1, 1956: Seaborn Collins, former national commander of the American Legion
• Jan. 1, 1957: El Paso Rotary and Kiwanis Clubs
• Jan. 1, 1958: Hugh M. Milton II, assistant secretary of the Army
• Jan. 1, 1959: Tom Lea, artist and author
• Jan. 1, 1960: New Mexico Gov. John Burroughs
• Jan. 1, 1961: Conrad N. Hilton, president of Hilton Hotel Corp. and director of El Paso National Bank
• Jan. 1. 1962: Richard Lopez, El Paso's National Boy of the Year
• Jan. 1, 1963: Ambassador Raymond Telles, former El Paso mayor
• Jan. 1, 1964: Capt. Mildred L. Clark, Army Nurse Corp.1968
• Jan. 1, 1965: Chris Fox, banker, 1944 Sun Bowl president
• Jan. 1, 1966: Actor Gilbert Roland
• Jan. 1, 1967: UTEP coaches Bobby Dobbs and Don Haskins
• Jan. 1, 1968: Emmett Kelly Jr., world-famous circus clown
• Jan. 1, 1969: Mickey Mouse
• Jan. 1, 1970: Golfer Lee Treviño
• Jan. 1, 1971: Singer Vikki Carr
• Jan. 1, 1973: Miguel Pedraza, governor of the Tigua community
• Jan. 1, 1974: Lt. Cmdr. Aubrey Nichols, Vietnam POW
• Jan. 1, 1975: Mickey Mantle, Major League Baseball Hall of Famer
• Jan. 1, 1976: Maj. Gen. C.J. LeVan, commander Fort Bliss
• Jan. 1, 1977: Pat Summerall and Tom Brookshier, CBS sports broadcasters
• Nov. 22, 1978: General of the Army Omar N. Bradley
• Nov. 22, 1979: Congressman Richard C. White
• Nov. 27, 1980: State Sen. Tati Santiesteban, honorary grand marshal Gen. Omar Bradley
• Nov. 26, 1981: Astronauts Robert Crippen and Joe Engle
• Nov. 25, 1982: Miss Universe Karen Baldwin
• Nov. 24, 1983: Bruce Weitz, actor
• Nov. 22, 1984: Ana Alicia, actress
• Nov. 28, 1985: Miss USA Laura Martinez Herring
• Nov. 27, 1986: Dr. Bonnie Dunbar, astronaut
• Nov. 26, 1987: Don Maynard, NFL Hall of Fame inductee
• Nov. 24, 1988: Patrick Baca, actor
• Nov. 23, 1989: Garfield
• Nov. 22, 1990: Don Haskins, UTEP men's basketball coach
• Nov. 28, 1991: Jim Meskimen, the Jewel Osco Guy
• Nov. 26, 1992: Little Joe Hernandez, singer
• Nov. 24, 1993: Major League Baseball players Frank Castillo and Butch Henry
• Nov. 24, 1994: Jack C. Vowell
• Nov. 23, 1995: Jim Lovell, Apollo 13 commander
Want more news like this? Click here to subscribe to elpasotimes.com.
• Nov. 28, 1996: Buzz Lightyear
• Nov. 27, 1997: Tom Lea, artist and author
• Nov. 26, 1998: El Paso Buzzards President Jim Burlew and team coach Todd Brost
• Nov. 25, 1999: No grand marshal
• Nov. 23, 2000: Andrew Nemeth III, USS Cole Fireman
• Nov. 22, 2001: Sam Donaldson of ABC News
• Nov. 28, 2002: Tristan Gale, Olympic gold medalist
• Nov. 27, 2003: Former POWs Spc. Shoshana Johnson and Cpl. Joseph Hudson
• Nov. 25, 2004: Alejandro Hernandez, actor. UTEP basketball coach Don Haskins, Jessica Silva and Rene Hernandez Armijo were honorary grand marshals.
• Nov. 24, 2005: Bugs Bunny, Sylvester the Cat and Tweety Bird
• Nov. 23, 2006: Ron Capps, a National Hot Rod Association professional funny-car driver
• Nov. 22. 2007: Haywood Jeffries, Houston Oilers wide receiver, and Fort Bliss' 4th Brigade Combat Team, 1st Cavalry Division
• Nov. 26, 2008: Ray Mickens, Andress High School and NFL football star
• Nov. 26, 2009: Dora the Explorer
• Nov. 25, 2010: The city of El Paso for being named the 2010 All American City
• Nov. 24, 2011: Bill Macatee, a 1973 graduate of Burges High School, CBS sportscaster
• Nov. 22, 2012: Iron Man, Thor and Spider-Man
• Nov. 21, 2013: Austin Trout, professional boxer
• Nov. 28, 2014: Nolan Richardson, National Collegiate Basketball Hall of Fame and the Naismith Memorial Basketball Hall of Fame inductee.
• Nov. 26, 2015: Members of the 1966 Texas Western College (now the University of Texas at El Paso) NCAA basketball championship team
• Nov. 24, 2016: Ginger Kerrick, a flight director who serves in the Mission Control Center at the NASA Johnson Space Center in Houston
• Nov. 23, 2017: 14 World War II veterans from El Paso
• Nov. 22, 2018: WWE Superstar Sin Cara, who grew up in El Paso and Juárez
• Nov. 28, 2019: Ron Stallworth, author of "Black Klansman"
Man dies in East El Paso stabbing; one wounded in Lower Valley shooting Burges grad Savannah Marenco makes impact on high-ranked Odessa College volleyball team Human remains found in Castner Range near Border Patrol Station in Northeast El Paso El Paso Times sports scoreboard for March 19


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History of the Alexander Technique
The Alexander Technique was developed by Australian actor and reciter Frederick Matthias Alexander (born Tasmania 1869 – died London 1955).
Alexander began to experience vocal problems during his performances. When doctors were unable to help him he decided to search for a solution himself. He practised reciting in front of mirrors and, over time, he noticed a habitual reaction which caused him to tense his neck. Gradually, he managed to unlearn this habit. As a result, his vocal problems stopped, he moved with greater ease and his overall well-being improved.
Alexander realised the importance of the relationship between the head, neck and back - the spine - and how this affects the whole body. He called this the "primary control". Often, as we grow up, we develop unconscious habits of "mis-use" which interfere with the body's primary control. These can lead to disorders, particularly chronic back, neck and head pain, and shoulder, wrist and knee problems. Alexander continued to refine his theory and, in the 1930s, began to train others to teach what is now known as the Alexander Technique. His four books, Man's Supreme Inheritance (1910), Constructive Conscious Control of the Individual (1923) The Use of the Self (1932) and The Universal Constant In Living (1941) are still widely read.
Today, the Alexander Technique is a well-established practical method of self help that can enable you to avoid pain and manage your life more effectively. Posture Plus in North London offers a simple, clear approach to learning the Alexander Technique.
To find out more about Alexander Technique with Posture Plus in North London call 020 8882 5134 or email [email protected].
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Health and wellness tips for your work, home, and life—brought to you by the insurance and healthcare specialists at eIndividualHealth.
Exercise is a great way to combat stress, lose weight, and boost energy. To get the most from your workouts, you will want to add warming up, cooling down, and stretching to your routine. These three simple steps are proven in helping to prevent painful and costly injuries later.
Most experts agree that the childhood obesity crisis has been caused as much by children's lack of physical activity as it has by their poor diets.


Forget about using Facebook and Twitter to communicate with friends and share messages. The biggest trend hitting Wall Street bankers these days is Snapchat.
Wall Street bankers are using Snapchat to send pictures to one another without the leaving any incriminating evidence online, reported in New York magazine.
\"In an industry where a stray Facebook photo of a drunken escapade can get a junior banker fired on the spot, Snapchat\'s disappearing photos have made it a useful tool for Wall Street\'s party crowd,\" the magazine reported.
Pictures sent using Snapchat disappear within seconds after being opened by the receiver and can\'t be viewed again. Which would explain the firm's mascot: Ghostface Chillah.
Popular among teenagers, this technology is seen as particular useful on Wall Street, where away from the watchful eye of company compliance, young bankers can be free to express themselves without worrying about any incriminating evidence afterward. No one sees the message except the person it\'s sent to, not even Snapchat, according to the firm's private-policy information on its website.
This technology is straight from Hollywood. Remember how Tom Cruise in Mission Impossible had 30 seconds to listen the message before it self-destructed?
It's not clear how many people on Wall Street are using Snapchat, but according to the report, Snapchat transmits about 150 million shared photos a day.
But it's not foolproof. Someone can take screenshot of the photo that is sent.
And reports last month suggested that pictures sent with Snapchat aren\'t actually deleted after they are viewed, but are instead given a \"no media\" file extension, making them easily recoverable by forensics experts, geeks, and law-enforcement officials.
And of course, given recent revelations of National Security Agency surveillance, it seems likely your spontaneous snaps are probably going to live forever on a super secret server somewhere.
The app does let the sender know if a screenshot was taken of their \"eyes-only\" pictures. The app also lets you draw on the photos giving a more personal touch or even takes videos with sound to send to users.


HealthCrowd, text-message-based patient engagement strategy, has completed a pilot with New York Medicaid plan Healthfirst, showing that 86 percent of Healthfirst's Medicaid population was equipped to receive text messages.
"Over 80 percent of the population we intervened on had a mobile phone," Neng "Bing" Doh, HealthCrowd's CEO and cofounder, told MobiHealthNews in an exclusive interview. "Historically, a lot of Medicaid plans have had the preconception that because their members were lower income, that they didn't have mobile phones. Another preconception is that people don't want to pay for these messages or [that they] find them intrusive. We absolutely debunked that as well. Our response rate was anywhere from 30 to 60 percent and our opt out rate was really really low; it was 3.7 percent."
HealthCrowd worked with 941 patients for two and a half months during the study. The target group was pregnant women and families with children and teens, and the interventions were designed to encourage families to get vaccinations, well child visits, and/or prenatal care.
First off, to address concerns Doh says HealthCrowd frequently encounters, they scrubbed Healthfirst's phone database to determine that 62.9 percent of the phone numbers were cellular, 23.5 percent were voice over internet protocol, and only 13.4 percent were landlines. They also reported how many users opted out of the service -- just 34 of the 941 -- and how often the users responded to the interactive messaging. The average response rate was 30.7 percent.
Finally, Doh and her team also wanted to look into whether the text messages were actually successfully driving action, getting parents to bring their children in for a vaccination or checkup.
"We found out with 80 percent confidence, members who responded more, or who were chattier were actually more likely to take action, so that was quite interesting," said Doh. "And in terms of outcomes we were also able to demonstrate that our program was able to get 32 percent of the members that participated to take an action in just a little shy of two and a half months."
The company also projected that, if given a full year, they could get that number up to 86 percent. In terms of cost effectiveness, the study showed that HealthCrowd's text messaging platform was 15 to 100 times more effective than other modalities and provided a three to 30 times better return on investment (ROI) when normalized for cost.
Specifically, it was 100 times more effective than postcards, 50 times more effective than buckslips in mailers, 30 times more effective than voice calls, and 15 times more effective than email. The ROI was 30 times as good as postcards, 35 times as good as buckslips, seven times as good as voice calls, and three times as good as email.
Smartphone apps were not addressed in the study, but just as she asserted when MobiHealthNews talked to HealthCrowd in 2012, Doh maintains that text messaging is still better positioned to reach more patients.
"About 40 percent of these members actually have smartphones," she said. "But as we discussed back in 2012, and I think it's still true, it's really hard to get a patient or a member to actually download an app the health plan wants them to download and it's even harder to get them to use it. So we see text messaging not only as a very strong communications channel, but one that will increase in usage over the next three to five years."
That said, as of a few months ago, HealthCrowd provides options for health plans that don't want to use text messages or exclusively text messages. HealthCrowd 2.0 launched in June and added instant messaging, email, interactive voice response, web and mobile web, social media and paper-based outreach to its portfolio.
"We want to help health plans engage their members in any way in which they want to reach out and any way that patients might respond," Doh said. "There's always going to be a subset of the population that maybe doesn't want to communicate via text and if that's the case, we have a holistic solution."


Since playing grouped sports as a kid, I have been told that "There is no I in Team". The notion was that each member had a role to play and the whole was bigger than an individual. This conjures up the image of the poster that says, "TEAM – Together Everyone Achieves More". I still believe that to be true but I would like to promote a different spin. I believe that there is an I in Team and that "I" stands for Inspiration. This is particularly true for Team In Training.
I am still proud and Inspired fifteen years later by how my father dealt with his diagnosis of CML and with the manner and grace he lived out his shortened final days. His inspiration is what eventually got me into the Team In Training program. I am just as inspired with how my mother, a cancer survivor herself, managed through losing her husband and carrying on alone these last fifteen years.
We are greatly Inspired by our current honored heroes and each of the honored heroes from previous seasons. They have opened up their lives and struggles to us as they manage through what must be a very, very scary thing. Their courage is amazing.
I find Inspiration in my fellow lane one swimmers. You will not find a group with more heart. By the way when my mother asked me how my swim training was going, I proudly told her that I was in lane one. She thought that was great. I chose not to correct her thought that the speedsters were in the other end of the pool. If you see my mother, let's keep that our secret!
Great Inspiration is found by all of our fellow teammates who initially had the courage to commit to raise money while preparing for an endurance sport and then the additional courage to recommit through the event. The dollar tally announced at the Inspiration Dinner that represents the aggregate of all of the hard work from their silent auctions, garage sales, bake sales, car washes, letter writing campaigns, et cetera being still provides goose bumps. Extra inspiration comes from those Alumni that do this season after season after season.
We receive Inspiration by our TNT coaches, mentors and LLS staff, who give so much of themselves, well beyond what is asked but because they want to, so that we may be successful in our journey.
Don't forget the Inspiration by the efforts of the researchers that our raised dollars fund and the progress that is being made every day. We are inspired that some day cancer will be a disease of the past and that we will have a grand last event celebration where we will claim victory.
John Dapper is currently training for The Nation's Triathlon 2010 team and has been involved with Team In Training in a number of roles including participant, mentor and now coach. John brings extensive experience from having participated with various chapters of Team In Training and has a strong passion for the cause.
I've always heard the saying that a lot can happen in five years. So I started thinking, what all can happen in five years? Well, it takes nine months for a baby to be born. You can start and finish college; well at least that's the theory anyway. In my case, you can graduate from college, move to a new city, train for and complete two half-marathons and a marathon with Team In Training. Oh yeah and be in the middle of training for your second marathon. It seems like I've done a lot in those five years and to be honest, I'm not sure where the time has gone. However, in five years, I still have not learned how to come to grips with losing a friend to a blood cancer.
You see, I recently celebrated my seventh year off chemo anniversary in April. While going through chemo, I met a lot of kids who were also fighting the terrible c-word. One of the people that I met who was also battling cancer, Todd, ended up becoming my best friend. I met Todd when I was fifteen and he was sixteen. He was diagnosed in May of 2000 and I was diagnosed in September of 2000. We both had ALL (acute lymphocytic leukemia). As Forest Gump would say, we went together like peas and carrots. We were completely opposite but yet, it worked. I was always really feisty (and still am); Todd was more laid back and would roll with the punches. I was an athlete and he was in the band. I was (and still am) an Ole Miss fan; he was an Auburn fan (which in the state of Alabama, things like that can make or break a friendship). The one main thing we had in common was that we each needed a friend, someone who knew what the other was going through and would take each other's mind off of the reality of what was happening. You see, we didn't need sympathy, we needed normalcy and we provided that for each other.
It took us each about three years to finish chemo. I completed my chemo regiment before graduating high school, but Todd had to enter his freshman year at Auburn still on treatments. I finished with relatively few setbacks. Todd had a harder time. I was lucky enough to have never relapsed. Todd relapsed and needed a bone marrow transplant. He traveled to Boston for his transplant and I remember being a freshman in college and spending my weekends talking to him over the computer so he could have some company, so-to-speak. I remember one Saturday in particular, we talked for twelve straight hours, with only a few breaks to go to the bathroom or get something to eat. Needless to say, he was my best friend and I loved him dearly.
After he finished his transplant, he was allowed to come back to Alabama and start his sophomore year of college. He had decided to transfer to a school closer to his Alabama doctors, so he chose to enroll at Samford University in Birmingham. I was really excited about this, because I too was going to be a sophomore at Samford. That summer, I had to decide to stay at Samford or transfer to another school. I made the painful decision to transfer, but I knew that one day, the stars would finally align and we would find our way back to each other. Todd stayed right on track though and enrolled for the Fall 2004 semester. At least he was right on track until he hit another detour. A few months into the semester, he relapsed for the second time. This was not a good thing. The leukemia started showing up all over his body, not just his blood. I saw him a couple of times during this go-round and we would talk periodically. I just knew he was going to be OK. He would bounce back just like he did the previous two times.
Unfortunately, five years ago today, July 19th, Todd passed away. To say that I was devastated was an understatement. How could this happen? We were Mal and Todd, The Dynamic Chemo Duo. We were supposed to grow old together and conquer the world, because if we could conquer cancer, then the only thing left was the world. But I guess it wasn't in the cards for us. I had to learn a hard lesson in life, that sometimes things don't go the way you plan.
Sometimes I catch myself wondering what could have been and how different the past five years would have been if he were still around. Last Wednesday, I really started thinking about how much I missed him. I called my mom and she told me the one thing I needed to hear. She told me that Todd would be mad at me for being sad and dwelling on it. And she's right. He would've wanted me to take that pain and sadness and turn it in to something good. I have finally started to realize that just because Todd's not here to conquer the world with me, I can still conquer it. People who find out that I run half-marathons and marathons ask me why I run. I usually tell them that I run because I can. What I should probably say is that I run because Todd can't, but more importantly, because I can and that's what he would want me to do.
Mallory Chandler celebrated her seventh year anniversary as a survivor at the 2010 Country Music Marathon. She is now set to do the 2010 Chicago Marathon with Team In Training. Mallory, thank you for continuing to inspire us all! You, Todd and so many others are why we do what we do.
After only a few weeks of group runs and getting to know my new "team" I knew I had found friends for life as well as the courage to switch from my 1/2 marathon to a full marathon. The fundraising it turned out, was the easy part. When I had signed up to run, I didn't think I knew anyone that had battled a blood cancer-most of my family members who have been affected by cancer were usually fighting a different type. Throughout the several months of training I quickly realized how wrong I was and that I knew several people that were my new honored heroes that were battling, have battled, or lost their battle to a blood cancer. I was also really touched by another survivor, one of my new teammates, Ryan Watton.
I knew that once I got to Seattle and began my 26.2 mile adventure that things would be emotional. Seeing the many other TNT'ers from across the country dressed in their purple and hearing "Go Team" cheers along the way really helped get me through my run. I also knew my knee and foot pain wasn't nearly as bad as a chemo treatment and thinking about my honored heroes and what they have been through, or what they are currently going through didn't compare. I knew that all of my training, hard work, and fundraising was for them. Crossing the finish line was an amazing experience that brought me to tears, but what really moved me came later that night.
After the race our team went out to celebrate. We got into the conversation of honored heroes and why we do what we do. Throughout training (and my race) I was asked why I was running and who I was running for. I was doing this for a cause greater than me and didn't think much more about it. Ryan brought it all into perspective. I quickly came to realize that I am a hero too. Our heroes think we are heroes. They are so thankful that we would spend our time and be so dedicated to running for them and are inspired that we would do this in their honor. Throughout the whole experience I never really looked at it this way. I never thought what I did could compare to what they were going through. I was wrong. We both inspire each other, but in different ways.
Team In Training has been a life changing experience that I will never forget. Not only did I make great friends, I learned a lot about myself, my capabilities, and the fight against cancer. I can't wait to do it all again. Big Sur anyone??
Elizabeth Kalifeh is a first time Team In Training participant and we are very proud of her accomplishment. Congratulations Elizabeth! Thank you for your commitment to Team In Training and sharing your story.


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Bill Pardue
Suicidal Blonde (filed in Rated G on February 20, 2012)
A Holiday Warning (filed in Puns, Rated G, Shaggy Puppy on December 20, 2011)
My New Play Toy (filed in Picture Pun, Rated G on August 18, 2011)
Vignettes of When the Fight Started… (filed in Rated G, Rated PG-13, Shaggy Puppy on July 19, 2011)
Alzheimer's Test for Modern Seniors (filed in Rated PG-13 on July 8, 2011)
ChapStick (filed in Rated PG, Shaggy Puppy on February 20, 2011)
Entering Paradise (filed in Rated G, Shaggy Puppy on November 13, 2010)
An Effective Comeback (filed in Adult Theme, Puns, Shaggy Puppy on October 13, 2010)
Texas Wisdom (filed in Rated PG, Shaggy Puppy on July 24, 2010)
Pray for LeRoy (filed in Rated G on May 14, 2010)
A Change in Profession (filed in Rated PG-13, Shaggy Puppy on April 25, 2010)
An Italian Confession (filed in Rated PG, Shaggy Puppy on April 18, 2010)
Blonde's Flat on the Interstate (filed in Puns, Rated PG-13 on April 7, 2010)
Texas Medley (filed in Poetry, Rated G on July 2, 2006)
A Good Pun Is Its Own Reward (One-Liners) (filed in Puns, Rated G on January 16, 2006)
Two Drops of Water (filed in Rated G on November 6, 2005)
Regis and The Blonde's Final Answer (filed in Rated G on August 20, 2005)
Oh Lordy (filed in Rated G on July 18, 2005)
Osama in Heaven (filed in Puns, Rated PG-13 on December 26, 2004)
On a Texas Highway (filed in Politically Incorrect, Rated G, Shaggy Puppy on November 20, 2004)
Deer Hunting in Texas (filed in Rated G, Shaggy Puppy on )
Norwegian Firefighters (filed in Rated PG, Shaggy Puppy on May 22, 2004)
More on the War of the Sexes (filed in Rated G, Shaggy Puppy on )
Politics (But not PC) (filed in Politically Incorrect on January 25, 2004)
Coach Boudreaux (filed in Rated PG, Shaggy Puppy on )


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I have seen bits and pieces of this floating around here, but wanted to see if anyone has actually fully done this. I want to have two text input fields where the user will enter their name and email address accompanied by a submit button. Upon clicking the button I would like to pass those inputs as variables via JS to a php file that will generate and send and email to the instructor. Can anyone point me in the right direction?
Hi Scott! Hopefully someone in the community will be able to assist you with this as this is not a method supported by Articulate.
I think you could get this working using google docs.
See here for details on how to pass data from Storyline to a Google form.
Thanks Matthew. I went the JS pass variable to PHP mail route, but I am going to keep that suggestion in my pocket for a later date.


Competitive. Crowded. Content marketing is tough.
Low barrier of entry… Anyone can write and press the publish button.
High competition… Huge players have already built massive audiences.
So how are you doing? Are you beating your competition at content marketing? It's a tough question to answer. There are lots of ways to measure.
Which brand is more committed to content?
Which brand is getting more traction?
Which brand is likely to win in the future?
This competitive content analysis covers six main areas: content, traffic, search optimization, social media, email marketing and advanced content strategies.
There isn't one, unified dashboard that analyzes your content marketing against your competitors using all of these criteria. So at the bottom of this post, we've invented one. But first, let's drill down into each and find the data.
How big? How fast? First, let's get a sense for the size of their site, then let's look at how often they publish.
LBOW stands for "lifetime body of work" and it matters. Some brands have published tons of content. Others have far fewer useful articles on their domain. More isn't always better, but it's a factor.
To see the total number of pages on your site and the site of any competitor, use the "site" operator while searching in Google. Just search for "site:http://webaddress.com" and you'll see the number of pages on that domain.
I don't know of a tool that measures this, so you'll have to go to their site and start counting posts. It will be easy to find, as long as they have dates on their content.
ProTip: We actually recommend removing the dates from your own blog, unless you publish news. Dates on blog posts are one of 15 things you should remove from your website.
Publishing more often doesn't necessarily mean they're winning, but it's another factor.
There are many tools that estimate traffic, and they're all inaccurate to varying degrees. Alexa is probably the most popular. SimilarWeb is probably the most accurate. So let's use those two.
Alexa ranking doesn't show traffic estimates, but it's a very common way to get a sense for how popular a website is. Higher rankings (as in, a lower number) should indicate more traffic. According the article cited above, the correlation is .702.
Bonus: If the site is popular enough, Alexa will show you demographic data for the visitors.
This is a great tool for all kinds of competitive analysis. And the correlation between SimilarWeb rankings and traffic is higher, .827. It's more accurate.
Bonus: If the site is popular enough, SimilarWeb will show you traffic sources, including referring sites!
Rankings are public, so it's easy to get data on the competition's SEO efforts. We recommend two tools for this, Moz and SEMrush. Moz shows the general likelihood of ranking. SEMrush shows the number of phrases they're raking for.
This is a powerful indicator of the strength of the competition. Domain Authority is the overall ranking potential of you and your competitors. Whoever's higher has more horsepower in search. The quickest way to compare you to them is to enter you both into Open Site Explorer.
Use the "Compare Link Metrics" tab to see the specifics, including the number of sites that link to each of you.
Use SEMrush to check their rankings. Most website rank for hundreds (if not thousands) of phrases. Just enter your websites into this tool and look at the number in the lefthand column.
Of course, you both already rank for your business names, so that doesn't count. What matters is the number of "non-branded" keyphrases. Those are the phrases that don't include the business name. If you have the paid account (worth it!) you can use a filter to remove these branded phrases.
This is another important yardstick. The advantage goes to the brand with the larger, more engaged following. The winner here gets more social traffic and greater networking benefits.
Pick whichever network is important to your brand. That often means Facebook for B2C brands and LinkedIn for B2B. Twitter tends to be relevant to everyone. Next, just compare the size of your following to theirs.
There are tools that measure the growth rate of a Twitter following. They simply show average daily new followers minus average daily unfollowers. User the "Compare Users" feature in FollowerWonk. Make sure to select "Compare Users They Follow" from the dropdown menu.
As we know from previous research, the biggest factor in follower growth isn't activity or "authority," it's the size of the following (source). The rich get richer, it seems.
If you're looking to grow your following fast, here's our Semi-Legit Guide to Getting More Twitter Followers.
Who gets shared the most? Some marketers are good at making sharable content. Some marketers are just good at getting others to share.
Lots of factors contribute to sharing: headlines, visuals, using contributors (see below) and social automation tools. Regardless of how they do it, here's how to find out how much they get shared.
With the BuzzSumo free version, you can see what gets shared the most on your domain and theirs. But in BuzzSumo Pro (or with a free trial), you can do a domain comparison and see the average shares, you versus them, on every social network.
Now you've got a good sense for who's getting more social traffic.
It's a controversial metric, but it does mean something. Klout is based on 400+ signals. It's a measure of "influence" as in the likelihood that others are interacting, responding, answering, favoriting, liking and sharing.
A high Klout score means they're doing more than just dumping links into social streams.
Every serious marketer I know is intensely focused on email marketing. Unlike most traffic sources (Google, Facebook, Twitter and LinkedIn) email is not a company. It's the list you own. It makes you less beholden to those companies to drive traffic.
With email, there's no company acting as the intermediary between the reader and the brand. Here are the two main ways to do a little email marketing competitive analysis.
This is a key comparison. It's also not necessarily visible. If your competition knows how to optimize an email signup form by adding social proof, the number of subscribers might be right there on the blog or in a popup window.
If not, try asking them on social media. They might just send a quick response!
As with publishing on the blog, there isn't an easy way to measure this. Just subscribe to your competitors newsletter and count the emails as they come in.
Content can go far beyond blogging. Some brands are doing much more in creating and promoting their content. Let's give credit to those strategies and show who is giving themselves a competitive edge.
As we've reported already, 75% of content get no links and almost no shares. But one format for content rises above all others: research.
Look for original research that creates new data and statistics: charts, graphs, percentages and sound bites that were published there first, before they appeared anywhere else. These are probably the pages with the most links (according to Open Site Explorer) and shares (according to BuzzSumo).
Including keywords is good for search traffic. Everyone knows that. But here's something most marketers miss: including people is good for social traffic.
Our competitive analysis of content marketing includes a check into collaboration. So browse through recent articles, looking for ego bait; content that includes the faces, names and voices of influencers.
Marketers who collaborate with others on their content get big networking and social media benefits over the long haul.
Tip: Email interviews are a fast, powerful way to get more people involved in your next article.
It's a more aggressive, more effective way to grow an email list. Marketers love popups, even if visitors don't.
Oli also shared the difference between average and excellent. It's all about relevance, value, timing and design.
Are you already using popups? Use these benchmarks as another way to compare your content marketing to others.
As with popups, retargeting is another way to more aggressively improve branding and traffic. A retargeting campaign uses a tracking pixel and a cookie, so after a visitor comes to your website, ads appear on other websites, encouraging them to return.
Advertising isn't content marketing. In fact, it's the opposite. But retargeting works so well with content that we've included it here. Companies that combine content with retargeting have a competitive advantage.
A bad content marketer publishes only blog posts. A good content marketer goes beyond the blog, into more compelling formats. Here are three that lead to a significant competitive advantage.
If the competition is moving into these formats, they may be building a durable advantage in brand awareness, trust, networking and demand generation.
Here's our totally made-up dashboard that compares the content marketing of two companies. This competitive content analysis will be of two companies that we have no connection to: CoSchedule and Divvy.
How did your content do in the final analysis?
If you're content didn't stack up well against your competitor, don't worry. This is a game that's never over. It's not too late to focus and build up your edge in any of these categories.
This scorecard made it look like DivvyHQ is losing. In fact, it's an excellent tool with a huge loyal following and a blog with a lot of great content. Brody Dorland is a champion marketer.
If your competition is ahead of you, they probably started before you.
There is no way to see the conversion rate for a website, but it's critical. If the competitor has twice the conversion rate, they'll get the same results as you, even if they have just half as much traffic.
You can set a Talkwalker Alert to see mentions of their brand name, but it's still hard to tell if they are active guest bloggers or just good at PR. Either way, what happens on other websites is key to content marketing success.
Does their content stink? If so, nothing else really matters much.
This scorecard shows one thing: which brand is better at giving away information. Content is a gift and the brands who are the best at giving it are the brands that win.
So if you plug in your scores, and you you're not winning, give more. Work harder to put free information on the web and work harder to make sure people see it. That's really what it's all about.
Great article Andy! Very helpful!
I wonder, what about social listening? I believe that we can use tools like i.e. BRAND24 internet monitoring for tracking our competitors, analyze their reach and influence, know their influencers, see what their customers saying online about them. This is also a great source of knowledge we can use for our purpose and be few steps before them!
Excellent point, Gloria. It's super smart to listen to your competitors. I've used Talkwalker Alerts, but not Brand24. I've heard good things about it.
Does it quantify things somehow? I'm wondering how this might fit into my imaginary scorecard..
Nice to hear 🙂 I'm sure that it would be useful for you, i.e. you can add informations about interactions and reach, measure the buzz.
In Brand24 you will find analyzes of reach, influence and sentiment, amounts of mentions, analyzes of author's influence and reach, discussions volume charts, comparisons. A lot of powerful data you can filter, compare and export.
Take a look at https://brand24.com/features/ to see dashboards and all features.
Thanks for sharing this blog. Content is the main factor for ranking of a website. But as you mentioned the frequency of blogs for about 5 times a week. Would it be really beneficial? As the blogs which are posted are to be posted in social media as well. So should all the blogs which ever posted (5 times a week) should be shared in the same frequency in social media?


As a former Mayor and Village Trustee of Nyack, no one knows the river communities and neighboring villages better than Nancy. After having worked as a photographer for 12 years, Nancy decided to change careers and became a real estate associate in 1997. Her life long interest in architecture and houses made this transition seamless. She enjoys the challenge of matching client's visions with the right homes.
Nancy's encyclopedic knowledge of the Rivertowns allows her to answer any question a client may have on local resources such as nursery schools, doctors, haircutters, yoga classes, etc. When she represents you in the sale of your home, her goal will always be to maximize the return on your investment.
Her marketing experience, coupled with the tools that Rand Realty has to offer, will get you the most exposure for your home and ultimately the most money for your home.
Whether buying or selling a home the journey is as important as the ultimate destination.


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Conradh na Gaeilge offers language lessons, has a book shop and is a meeting place for different teams. The closest Gaeltacht to Dublin is the County Meath Gaeltacht of Ráth Cairn and Baile Ghib which is 55 km away. Dublin was traditionally a city of two languages, English and Irish, a scenario discovered also in the space around it, The Pale. The Irish of County Dublin represented the easternmost extension of a broad central dialect area which stretched between Leinster and Connacht, however had its personal local characteristics.
In 2011, the town was ranked ninth of main world cities on the Copenhagenize Index of Bicycle-Friendly Cities. The similar index showed a fall to 15th in 2015, and Dublin was outdoors the top 20 in 2017. The Poolbeg Towers are also landmark options of Dublin, and visible from various spots across the metropolis. Government Buildings home the Department of the Taoiseach, the Council Chamber, the Department of Finance and the Office of the Attorney General. It was designed by Thomas Manley Dean and Sir Aston Webb as the Royal College of Science. The Irish Free State government took over the 2 wings of the building to serve as a brief lived house for some ministries, whereas the central building became the College of Technology until 1989.
Dublin grew much more dramatically through the 18th century, with the development of many new districts and buildings, such as Merrion Square, Parliament House and the Royal Exchange. The Wide Streets Commission was established in 1757 at the request of Dublin Corporation to control architectural requirements on the layout of streets, bridges and buildings. In 1759, the Guinness brewery was founded; and would ultimately develop to turn into the largest brewery on the planet and the most important employer in Dublin. Other localities in Ireland additionally bear the name Duibhlinn, variously anglicised as Devlin, Divlin and Difflin. Historically, scribes using the Gaelic script wrote bh with a dot over the b, rendering Duḃlinn or Duiḃlinn.
It can also have been influenced by the east Ulster dialect of County Meath and County Louth to the north. This was the venue for house games of both the Irish Rugby Union Team and the Republic of Ireland nationwide football staff. A three means partnership between the Irish Rugby Football Union, the FAI and the Government, noticed it redeveloped into a new state-of-the-art 50,000 seat Aviva Stadium, which opened in May 2010.
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