text:
package com.amazonaws.auth;

import com.amazonaws.AmazonClientException;
import com.amazonaws.AmazonServiceException;
import com.amazonaws.AmazonWebServiceRequest;
import com.amazonaws.ClientConfiguration;
import com.amazonaws.SdkClientException;
import com.amazonaws.retry.PredefinedBackoffStrategies;
import com.amazonaws.retry.RetryPolicy;
import com.amazonaws.retry.RetryUtils;
import com.amazonaws.services.securitytoken.AWSSecurityTokenService;
import com.amazonaws.services.securitytoken.AWSSecurityTokenServiceClient;
import com.amazonaws.services.securitytoken.AWSSecurityTokenServiceClientBuilder;
import com.amazonaws.services.securitytoken.model.AssumeRoleWithWebIdentityRequest;
import com.amazonaws.services.securitytoken.model.AssumeRoleWithWebIdentityResult;
import com.amazonaws.services.securitytoken.model.IDPCommunicationErrorException;
import com.amazonaws.services.securitytoken.model.InvalidIdentityTokenException;
import org.apache.http.impl.client.DefaultBackoffStrategy;

import java.io.BufferedReader;
import java.io.Closeable;
import java.io.FileInputStream;
import java.io.FileNotFoundException;
import java.io.FileReader;
import java.io.IOException;
import java.io.InputStreamReader;
import java.util.concurrent.Callable;

public class STSAssumeRoleWithWebIdentitySessionCredentialsProvider implements AWSSessionCredentialsProvider, Closeable {

    /**
     * The client for starting STS sessions.
     */
    private final AWSSecurityTokenService securityTokenService;

    /**
     * The arn of the role to be assumed.
     */
    private final String roleArn;

    /**
     * An identifier for the assumed role session.
     */
    private final String roleSessionName;

    /**
     * Absolute path to the JWT file containing the web identity token.
     */
    private final String webIdentityTokenFile;

    private final Callable<SessionCredentialsHolder> refreshCallable = new Callable<SessionCredentialsHolder>() {
        @Override
        public SessionCredentialsHolder call() throws Exception {
            return newSession();
        }
    };

    /**
     * Handles the refreshing of sessions. Ideally this should be final but #setSTSClientEndpoint
     * forces us to create a new one.
     */
    private volatile RefreshableTask<SessionCredentialsHolder> refreshableTask;

    private RefreshableTask<SessionCredentialsHolder> createRefreshableTask() {
        return new RefreshableTask.Builder<SessionCredentialsHolder>()
                .withRefreshCallable(refreshCallable)
                .withBlockingRefreshPredicate(new ShouldDoBlockingSessionRefresh())
                .withAsyncRefreshPredicate(new ShouldDoAsyncSessionRefresh()).build();
    }

    /**
     * The following private constructor reads state from the builder and sets the appropriate
     * parameters accordingly
     * <p>
     * When public constructors are called, this constructors is deferred to with a null value for
     * roleExternalId and endpoint The inner Builder class can be used to construct an object that
     * actually has a value for roleExternalId and endpoint
     *
     * @throws IllegalArgumentException if both an AWSCredentials and AWSCredentialsProvider have
     *                                  been set on the builder
     */
    private STSAssumeRoleWithWebIdentitySessionCredentialsProvider(Builder builder) {
        this.roleArn = builder.roleArn;
        this.roleSessionName = builder.roleSessionName;
        this.webIdentityTokenFile = builder.webIdentityTokenFile;
        this.securityTokenService = buildStsClient(builder);
        this.refreshableTask = createRefreshableTask();
    }

    /**
     * Construct a new STS client from the settings in the builder.
     *
     * @param builder Configured builder
     * @return New instance of AWSSecurityTokenService
     * @throws IllegalArgumentException if builder configuration is inconsistent
     */
    private static AWSSecurityTokenService buildStsClient(Builder builder) throws IllegalArgumentException {
        if (builder.sts != null) {
            return builder.sts;
        }

        RetryPolicy retryPolicy = new RetryPolicy(
                new StsRetryCondition(),
                new PredefinedBackoffStrategies.SDKDefaultBackoffStrategy(),
                3,
                true);

        ClientConfiguration clientConfiguration = new ClientConfiguration();
        clientConfiguration.setRetryPolicy(retryPolicy);

        return AWSSecurityTokenServiceClientBuilder.standard().withClientConfiguration(clientConfiguration).build();
    }

    @Override
    public AWSSessionCredentials getCredentials() {
        return refreshableTask.getValue().getSessionCredentials();
    }

    @Override
    public void refresh() {
        refreshableTask.forceGetValue();
    }

    /**
     * Starts a new session by sending a request to the AWS Security Token Service (STS) to assume a
     * Role using the long lived AWS credentials. This class then vends the short lived session
     * credentials for the assumed Role sent back from STS.
     */
    private SessionCredentialsHolder newSession() {
        AssumeRoleWithWebIdentityRequest assumeRoleRequest = new AssumeRoleWithWebIdentityRequest()
                .withRoleArn(roleArn)
                .withWebIdentityToken(getWebIdentityToken())
                .withRoleSessionName(roleSessionName);

        AssumeRoleWithWebIdentityResult assumeRoleResult = securityTokenService.assumeRoleWithWebIdentity(assumeRoleRequest);
        return new SessionCredentialsHolder(assumeRoleResult.getCredentials());
    }

    private String getWebIdentityToken() {
        BufferedReader br = null;
        try {
            br = new BufferedReader(new InputStreamReader(new FileInputStream(webIdentityTokenFile), "UTF-8"));
            return br.readLine();
        } catch (FileNotFoundException e) {
            throw new SdkClientException("Unable to locate specified web identity token file: " + webIdentityTokenFile);
        } catch (IOException e) {
            throw new SdkClientException("Unable to read web identity token from file: " + webIdentityTokenFile);
        } finally {
            try {
                br.close();
            } catch (Exception ignored) {

            }
        }
    }

    /**
     * Shut down this credentials provider, shutting down the thread that performs asynchronous credential refreshing. This
     * should not be invoked if the credentials provider is still in use by an AWS client.
     */
    @Override
    public void close() {
        refreshableTask.close();
    }

    /**
     * Provides a builder pattern to avoid combinatorial explosion of the number of parameters that
     * are passed to constructors. The builder introspects which parameters have been set and calls
     * the appropriate constructor.
     */
    public static final class Builder {

        private final String roleArn;
        private final String roleSessionName;
        private final String webIdentityTokenFile;

        private AWSSecurityTokenService sts;

        /**
         * @param roleArn         Required roleArn parameter used when starting a session
         * @param roleSessionName Required roleSessionName parameter used when starting a session
         */
        public Builder(String roleArn, String roleSessionName, String webIdentityTokenFile) {
            if (roleArn == null || roleSessionName == null || webIdentityTokenFile == null) {
                throw new NullPointerException(
                        "You must specify a value for roleArn, roleSessionName and webIdentityTokenFile");
            }
            this.roleArn = roleArn;
            this.roleSessionName = roleSessionName;
            this.webIdentityTokenFile = webIdentityTokenFile;
        }

        /**
         * Sets a preconfigured STS client to use for the credentials provider. See {@link
         * com.amazonaws.services.securitytoken.AWSSecurityTokenServiceClientBuilder} for an easy
         * way to configure and create an STS client.
         *
         * @param sts Custom STS client to use.
         * @return This object for chained calls.
         */
        public Builder withStsClient(AWSSecurityTokenService sts) {
            this.sts = sts;
            return this;
        }

        /**
         * Build the configured provider
         *
         * @return the configured STSAssumeRoleSessionCredentialsProvider
         */
        public STSAssumeRoleWithWebIdentitySessionCredentialsProvider build() {
            return new STSAssumeRoleWithWebIdentitySessionCredentialsProvider(this);
        }
    }

    private static class StsRetryCondition implements com.amazonaws.retry.RetryPolicy.RetryCondition {

        @Override
        public boolean shouldRetry(AmazonWebServiceRequest originalRequest,
                                   AmazonClientException exception,
                                   int retriesAttempted) {
            // Always retry on client exceptions caused by IOException
            if (exception.getCause() instanceof IOException) return true;

            if (exception.getCause() instanceof InvalidIdentityTokenException) return true;

            if (exception.getCause() instanceof IDPCommunicationErrorException) return true;

            // Only retry on a subset of service exceptions
            if (exception instanceof AmazonServiceException) {
                AmazonServiceException ase = (AmazonServiceException)exception;

                /*
                 * For 500 internal server errors and 503 service
                 * unavailable errors, we want to retry, but we need to use
                 * an exponential back-off strategy so that we don't overload
                 * a server with a flood of retries.
                 */
                if (RetryUtils.isRetryableServiceException(ase)) return true;

                /*
                 * Throttling is reported as a 400 error from newer services. To try
                 * and smooth out an occasional throttling error, we'll pause and
                 * retry, hoping that the pause is long enough for the request to
                 * get through the next time.
                 */
                if (RetryUtils.isThrottlingException(ase)) return true;

                /*
                 * Clock skew exception. If it is then we will get the time offset
                 * between the device time and the server time to set the clock skew
                 * and then retry the request.
                 */
                if (RetryUtils.isClockSkewError(ase)) return true;
            }

            return false;
        }

    }
}


Crack detect stops playback during track 3 of the album Hotel Terminus (what's in a name ) by Erik Bosgraaf.
Until now this is the only album that is showing this behavior.
This never happened before and started since using the Lush^2.
I tried both versions of the album I have (one ripped and one downloaded).
So with an other USB cable this does not happen, everything else the same ?
In order to test it, can I just play that Track 03, or must the track(s) prior to that be played as well ?
See you in the mad house !
Yes, that's the correct album.
Uhhh, mmm, the same thing also happens when I switch back to the standard Lush cable.
Funny thing is it never happend before with this album, so it might be caused by a changed setting in XXHighEnd?
so it might be caused by a changed setting in XXHighEnd?
Stanley, yes. Only 10 days or so ago someone else came up with similar and I/we determined it was the too low Balanced Load setting. At least that is what I recall of it.
Somwhere in here, I'd say : Crack Detect issues using normal Ram OS.
Therefore I assume it's the music and I probably noticed it as off XXHE version 2.10.
So no big deal for now.


A man accused of committing a religiously aggravated assault during a protest against an inter-faith marriage is set to stand trial.
Gursharan Singh is alleged to have assaulted an official at a Sikh temple in Leamington on September 11 last year.
Singh, who gave his address to the court as that of a Coventry law firm, indicated a not guilty plea during a brief appearance today at Leamington Magistrates' Court .
Magistrates granted Singh conditional bail to appear at Warwick Crown Court for a further hearing on February 10.
He will be tried by a jury later in the year.
A total of 55 people were arrested by Warwickshire Police following last year's protest.
Only a handful of people were charged though in connection with the incident.


text:
Shanahan: Griffin III Won't Be Rushed Back
Redskins head coach spoke to the NFL Network earlier this week, offering encouraging news on the rehabilitation and timeline for franchise quarterback Robert Griffin III.
"[Griffin III] is over at the facility rehabbing all the time," Shanahan said with a smile. "He's going to set a record for coming back because that's how hard he works."
Griffin III is recovering from reconstructive surgery on a torn anterior cruciate ligament (ACL) and lateral collateral ligament (LCL), a process that can take upwards of a full year for some athletes.
Shanahan, Griffin III and team physician Dr. James Andrews have stayed in the headlines this offseason by offering remarkable updates that put Griffin III 'way ahead of schedule.'
While Shanahan did not commit to a timeline for his return to game action, there are hopes that his recovery will parallel that of Vikings running back Adrian Peterson, who started Week 1 of last season after less than nine months of recovery.
"[Griffin III] is ahead [of schedule], but there's a process that takes time," Shanahan said. "Robert is doing it the right way and we'll find out in July exactly where he's at."
Griffin III originally injured his LCL in Week 14 vs. the Baltimore Ravens, suffering a Grade 2 strain that held him out of the Week 15 contest.
By injuring the same knee one month later, critics suggested Griffin III was rushed back from injury and may not have been 100 percent. Shanahan assured the NFL Network that this will not happen again.
"He will not come back until he is 100 percent," Shanahan said of Robert Griffin III. "And he will be at that 100 percent level again, it's just a matter of when.
"I don't think anybody knows that until he goes out on a practice field and we can evaluate him on a day-to-day level."
Shanahan reiterated that second-year quarterback Kirk Cousins will take all offseason reps with the starting unit, setting him up as the first option if Griffin III is unable to open the season.
"You're hoping [Griffin III]'s ready, but you can't really plan for him to be ready," he said. "Robert [Griffin III] will have a lot of reps, but it will be mental.
"He'll be in the film room watching people on the practice field during his rehab, but you can get a lot done mentally as well."
Redskins Will Keep The Read-Option
Shanahan also addressed what can be done to protect Griffin III moving forward, but said changing the offensive scheme was not in anyone's best interests.
"I think when most people take a look at Robert, they say 'oh, you can't run the option,'" Shanahan said. "People don't realize that the option protects the quarterback.
"The thing I have to get with Robert is when to slide, when not to take a hit."
Griffin III took several colossal hits last season, including a head shot in the Week 5 game against the Atlanta Falcons and his aforementioned blow to the knee vs. the Ravens.
Shanahan credited his quarterbacks' competitive spirit, but maintained his long-term approach.
"These quarterbacks are so competitive, but they don't realize sometimes how valuable they are to your franchise."

redpajama_set_name: RedPajamaCommonCrawl


You are invited together with your spouse, partner, friends or guests. There will be champagne, buffet and soft drinks – and the opportunity to meet the Headmaster and this year's prefects.
Booking is now open. Tickets are £25 each until 13 January 2018, and £35 thereafter.
Recent Dover College leavers: paid up members of the OD Club get one free ticket during their first 3 years of leaving. Please email OD Admin stating name, house at school and years you were there for more information.
Bookings are not yet open for this event.
Cheque on way to admin before Christmas .Check pse this not double booked.
Ms Davies will be coming with Mrs Robinson Chairman wife!!!
Pse check if RAF Club Ok for room for me as sweeper bupper. This formalised for good orders sake!


Proverbs Quiz 4: Tick the correct answer from the choices given to complete each proverb. Click the lesson 'Examples of Proverbs 2' to find the answers for the incomplete proverbs.
Complete each proverb by filling in the correct missing word. Before you attempt to answer the quiz below you should click to read the lesson 'Examples of Proverbs 2' to find the answers for the incomplete proverbs. Proverbs are popular, memorable and wise sayings expressed in a brief and effective manner. Proverbs often advice about how to live your life. Learn proverbs with our collection of more than 100 famous proverbs that most native English speakers know. Test your knowledge of proverbs with the following quiz. All what you need to do is to complete the proverb using a suggested answer. Test your proverb power with our Proverbs Quiz 4 and use these famous proverbs in your essays to enhance your writing skills. Use these proverbs in your speech and elaborate your speeches. Have fun with learning these interesting proverbs!


text:
Dwyane Wade Is All About These Stylish Prive Revaux Sunglasses
Score these flattering shades uniquely designed by Jamie Foxx.
By Adrianna Freedman
Instagram/Men's Health
As we're closing in on the end of summer, people are trying to take advantage of the last days of the warm weather season and get outside for some good, old-fashioned fun in the sun. There is one accessory which always stays consistent with summer-goers, and that is a pair of sunglasses. While we all want a sturdy pair that hopefully won't break as we throw them around, there's also the concern of the questionable price tag in order to get the specs we want—literally and figuratively.
Well, basketball star Dwyane Wade seems to be on board with the rest of the world, as he flexed a cool, new pair of sunglasses on his Instagram account while encouraging fans to get out and vote this upcoming election season. The best part? Not only is the accessory part of a collaboration with one of favorite Hollywood style icons, they're also extremely affordable by celebrity standards.
A post shared by dwyanewade (@dwyanewade)
The sleek shades are part of the extensive Prive Revaux x Jamie Foxx collection, and given how unique the singer's fashion tastes are, it makes perfect sense why Wade (a fashion icon in his own right) would showcase a pair of his own. The brand prides itself on being fashion forward without breaking the bank, and given that its creative directors are well-known stylists to some of the biggest names in the entertainment industry (including one Jamie Foxx), they know a thing or two about finding the latest fashion trend without having to steep too deeply in their pockets.
Prive Revaux The One Sunglasses
priverevaux.com
If you're still debating whether to order yourself a pair, this might change your mind. Prive Revaux is also proud of its philanthropy, partnering with the organization RestoringVision in order to help people living in under-developed countries get the eye care not easily accessible to them. They're all about changing people's lives to give them a better future—exactly what Wade is doing when wearing the glasses to promote a day that determines the U.S.'s future.
Just as Wade is doing, the brand is more than just selling a pair of sunglasses. It's about creating a better future. And if it means you can look on trend with a reasonably affordable price point while doing it, what's better than that?
Adrianna Freedman Adrianna Freedman is the editorial fellow for Men's Health, where she focuses on entertainment, music, health and fitness.
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Best in Shoe


text:
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      <source src="{{ src }}"/>
    </video>

      <button on:click="togglePlay()">
        {{# if(playing) }} Pause {{ else }} Play {{/ if }}
      </button>
      {{ formatTime(currentTime) }} /
      {{ formatTime(duration) }}

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    playing: "boolean",
    duration: "number",
    currentTime: "number",

    updateTimes(videoElement) {
      this.currentTime = videoElement.currentTime || 0;
      this.duration = videoElement.duration;
    },
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    },
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      this.playing = true;
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      this.playing = false;
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    togglePlay() {
      this.playing = !this.playing;
    },

    connectedCallback(element) {
      this.listenTo("playing", function(event, isPlaying) {
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});

redpajama_set_name: RedPajamaGithub


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text:
Home Education Post-Secondary
The content in the beta is accurate and up to date. Feel free to give us your feedback which will help us to improve it!
Learn more about the post-secondary education landscape and various pathways that students can consider by reading our booklet on Post-Secondary Education (5.4mb .pdf).
Established on 1 April 1992, Institute of Technical Education (ITE) took over the role and functions of the Vocational & Industrial Training Board (VITB). Since its formation in 1992, ITE has focused its effort on establishing the institute as a post-secondary technical institution of excellence. The primary role of ITE is to ensure that its graduates have the technical knowledge and skills that are relevant to industry. ITE is the national authority for the setting of skills standards and the certification of skills in Singapore.
Polytechnics were set up with the mission to train professionals to support the technological and economic development of Singapore. Reflecting the wide range of abilities, aptitudes and interests of their students, the polytechnics seek to train students with relevant and specific skills for the workplace to give Singapore a competitive edge as we move into a knowledge-based economy. Today, polytechnic graduates are valued as practice-oriented and knowledgeable professionals, much sought after by industry.
The polytechnics are also a significant provider of continuing education and post employment professional development programmes and services.
There are currently five polytechnics in Singapore:
Joint Portal of the Polytechnics
Nanyang Polytechnic (NYP)
Ngee Ann Polytechnic (NP)
Republic Polytechnic (RP)
Singapore Polytechnic (SP)
Temasek Polytechnic (TP)
Public-Funded Universities
Autonomous Universities
Singapore's university education aspires to prepare students not only for today's world but also for a world where there will be jobs that have yet to be invented and challenges not yet foreseen.
The National University of Singapore (NUS) and the Nanyang Technological University (NTU) have initiated a number of innovative programmes, including the broadening of undergraduate education, the introduction of a core curriculum, collaborations with top foreign universities, and the establishment of inter-disciplinary centres. The Singapore Management University (SMU) offers a broad-based business curriculum modelled after that of the Wharton School of the University of Pennsylvania.
The Singapore University of Technology and Design (SUTD) nurtures technically grounded leaders and innovators for society and was established in collaboration with the Massachusetts Institute of Technology and Zhejiang University.
To provide further differentiation in the university landscape, the Singapore Institute of Technology (SIT) and the Singapore University of Social Sciences (SUSS) were identified as pioneers to develop an applied degree pathway with a strong nexus with industry, to cater to a broader range of students, learning preferences, and interests.
SIT was established in 2009 to provide industry-focussed university education for polytechnic upgraders, in partnership with renowned overseas universities. SIT became an Autonomous University in 2014 and began offering its own applied degrees in the same year. SUSS, formerly known as SIM University, was restructured into Singapore's sixth Autonomous University in 2017 and will focus on lifelong learning and social sciences. It provides university education to working professionals and adult learners by adopting a flexible learning approach through its part-time degree programmes to enable its learners to balance their career, family, and studies. It also began offering its own full-time applied degree programmes in 2014.
View the latest Joint Graduate Employment Survey results:
The Graduate Employment Survey (GES) is jointly conducted by NTU, NUS, SIT, SMU, SUSS and SUTD annually to survey the employment conditions of graduates about six months after their final examinations. Due to the different academic calendars, the results are available at different times.
The combined outcomes of NTU, NUS, SMU, SIT, SUSS and SUTD by course clusters can be found below. This is a new publication for GES 2018 and provides an industry-centric perspective of employment outcomes based on broad subject disciplines.
Combined Course Cluster-level Outcomes for NTU, NUS, SMU, SIT, SUSS and SUTD (598kb.pdf) [NEW]
Outcomes of degree programmes by individual AUs can be found below.
GES 2018
NTU GES 2018 (684kb.pdf)
NUS GES 2018 (516kb.pdf)
SIT GES 2018 (668kb.pdf)
SMU GES 2018 (475kb.pdf)
SUSS GES 2018 (455kb.pdf)
SUTD GES 2018 (623kb.pdf)
LASALLE College of the Arts & Nanyang Academy of Fine Arts
LASALLE College of the Arts and the Nanyang Academy of Fine Arts (NAFA) are private institutions providing post-secondary education in the arts. Both LASALLE and NAFA offer publicly-funded diploma programmes. The institutions also receive government funding for select degree programmes offered in partnership with reputable overseas universities. Refer to the following links for the lists of publicly-funded programmes for NAFA and LASALLE.
Other Government-Affiliated Educational Institutions
Industry-specific diploma, degree and graduate certificate programmes are also offered by educational institutions affiliated with other government agencies. These educational institutions include:
BCA Academy – the education and research arm of the Building and Construction Authority (BCA) – which offers full-time diploma programmes, as well as other courses, seminars and workshops, in construction, design and engineering.
Singapore Aviation Academy (SAA) – the training arm of the Civil Aviation Authority of Singapore (CAAS) – which offers short courses, diploma, degree and executive programmes relevant to the aviation industry.
IP Academy – the education and training arm of IPOS International (a subsidiary of the Intellectual Property Office of Singapore) – which offers executive programmes, corporate training, and undergraduate and postgraduate courses, in intellectual property and innovation.
These educational institutions and their programmes are not funded or regulated by MOE as they do not come under MOE's purview. More information on these institutions and programmes is available at their respective websites.
We have provided a list of frequently asked questions on Post-Secondary Education.


As co-founder and CTO of SwiftKey, Ben Medlock invented the intelligent keyboard for smartphones and tablets that has transformed typing on touchscreens.
SwiftKey's smart typing technology learns from each user to more accurately autocorrect and predict their most-likely next word, and features on more than 250 million devices worldwide. They were acquired by Microsoft in February 2016, for a rumoured $250 million.
At last month's Deep Learning Summit in London, Ben took to the stage for a fireside chat with writer Sally Davies, to discuss growing a successful startup, reinforcement learning, the Microsoft acquisition and more. Watch the video below for the full interview.
View more video presentations and interviews from the 2016 Deep Learning Summit in London on the RE•WORK video hub.
The next Deep Learning Summit takes place in Singapore next week on 20-21 October. Tickets are now limited, book your pass here.


As a SA, would it be appropriate to give my mentor a gift on my last day? They've really been helpful and have taken alot of time they could have been billing to help me this summer. Thoughts? Is this inappropriate because I am obviously hoping to receive an offer?
Anonymous User wrote: As a SA, would it be appropriate to give my mentor a gift on my last day? They've really been helpful and have taken alot of time they could have been billing to help me this summer. Thoughts? Is this inappropriate because I am obviously hoping to receive an offer?
I don't think it's inappropriate necessarily, but gifts for attorneys may be a fine line for not coming across awkwardly. I think a card with a handwritten thank you inside would suffice if this person is presumably an attorney. Any inexpensive gift like a gift card may seem cheesy since this person makes likely over $200k, and anything too expensive may seem brown-nosy.
Agree with this. I'm sure they have enough mugs, pens, etc. whatever neutral trinkets you might want to get them. Thoughtful (appropriate) card would be more meaningful.
I would forever love a mentee who brought me a nice box of chocolate or some treats from a local bakery, even though it's definitely not necessary or expected. I think that's a nice gesture without being over the top or awkward. Also, I'm hungry.
gingerbread wrote: I would forever love a mentee who brought me a nice box of chocolate or some treats from a local bakery, even though it's definitely not necessary or expected. I think that's a nice gesture without being over the top or awkward. Also, I'm hungry.
This. If an SA brought me a box of donuts, I'd be grateful.
I brought my mentor and his practice group staff cupcakes from his/her favorite bakery on my last day of the summer. They loved them!
When I summered, I gave my secretary a Starbucks gift card on the last day (this was a common practice at my firm). With regard to attorneys, I think a thoughtful note will likely be appreciated more than a tangible gift, but something like a coffee gift card could also be appreciated, depending on the person.
Maybe this was just my experience, but I was very close to my mentor (literally checked in with me every day, organized lunches for me to meet partners, etc.) so I definitely wanted to get him a gift. I understand this isn't a normal dynamic at a lot of big firms, but I made him like a basket of baked things, wine, and a gift card (not for very much) just to show my appreciation. For another associate who was like a unofficial mentor to me, I gave her a nice bottle of wine. The summer associate for our firm last year (I wasn't her mentor but we talked every day) gave me a nice bottle of wine and thoughtful card. It's totally up to you based on your relationship with them.


text:
A Mandatory Reading of Kant's Ethics?
Robert B. Pippin
Philosophical Quarterly 51 (204):386-393 (2001)
Robert Pippin
Kant on Freedom, Law, and Happiness. BY PAUL GUYER. (Cambridge UP, 2000. Pp. xii + 440. Price £12.95 or $19.95.) At the beginning of his Groundwork of the Metaphysics of Morals, Kant claims that an ordinary view of morality would have it that moral experience is essentially the experience of obligation. There are clearly occasions, he notes, when our own and others' interests would be greatly damaged were we to do what is morally required, and when no gain in satisfaction, happiness, well-being or flourishing can be imagined a consequence of the act, yet we understand that we are obliged anyway, unconditionally. We also reserve our highest approval for agents who do what is required just because it is required, who act 'from duty alone'.
Kant: Ethics, Misc in 17th/18th Century Philosophy
Kant: Freedom in 17th/18th Century Philosophy
Kant: Maxims in 17th/18th Century Philosophy
DOI 10.1111/1467-9213.00237
pq.oxfordjournals.org (no proxy)
jstor.org (no proxy)
Epistemic Teleology and the Separateness of Propositions.Selim Berker - 2013 - Philosophical Review 122 (3):337-393.
Consequentialist Kantianism.Michael Ridge - 2009 - Philosophical Perspectives 23 (1):421-438.
Kant-Bibliographie 2001.Margit Ruffing - 2003 - Kant-Studien 94 (4):474-528.
Philosophical Grounding For the Moral Law: In Defense of Kant's Factum der Vernunft.Daniel Paul Dal Monte - 2019 - Con-Textos Kantianos 9:178-195.
Mandatory and Self-Citation; Types, Reasons, Their Benefits and Disadvantages.Mohammad Hemmat Esfe, Somchai Wongwises, Amin Asadi, Arash Karimipour & Mohammad Akbari - 2015 - Science and Engineering Ethics 21 (6):1581-1585.
Ethics Vindicated: Kant's Transcendental Legitimation of Moral Discourse: Ermanno Bencivenga, 2007, Oxford University Press, Pp.Vii-189, ISBN: 978-0-19-530735-1, £32.99, HB. [REVIEW]Gary Banham - 2010 - Ethical Theory and Moral Practice 13 (1):111-112.
The Role and Meaning of Community in Kant's Ethics.Jennifer Mills Moore - 1986 - Dissertation, Harvard University
Imagination in Kant's Critique of Practical Reason.Bernard Freydberg - 2005 - Indiana University Press.
How Not to Argue Against Mandatory Ethics Review.David Hunter - 2013 - Journal of Medical Ethics 39 (8):521-524.
On An Older Dispute: Hegel, Pippin, and the Separability of Concept and Intuition in Kant.Dennis Schulting - 2016 - In Kantian Nonconceptualism. London: Palgrave-Macmillan. pp. 227–255.
Reading Onora o'Neill.David Archard, Monique Deveaux, Neil Manson & Daniel Weinstock (eds.) - 2013 - Routledge.
Do We Always Act on Maxims?Sven Nyholm - 2017 - Kantian Review 22 (2):233-255.
Freedom, Truth, and Possibility in Foucault's Ethics.Réal Fillion - 2005 - Foucault Studies 3:50-64.
The Genesis of Heidegger's Reading of Kant.Garrett Zantow Bredeson - 2014 - Dissertation, Vanderbilt University
Chinese Ethics and Kant.Julia Ching - 1978 - Philosophy East and West 28 (2):161-172.
The Mandatory Corporate Social Responsibility in Indonesia: Problems and Implications. [REVIEW]Patricia Rinwigati Waagstein - 2011 - Journal of Business Ethics 98 (3):455 - 466.
Chapter 1. Reading Kant in Herder's Lecture Notes.Steve Naragon - 2015 - In Robert R. Clewis (ed.), Reading Kant's Lectures. De Gruyter. pp. 37-62.
What We Should Treat as an End in Itself.Richard Curtis Dean - 1999 - Dissertation, The University of North Carolina at Chapel Hill
A Consciência De Si Como Sujeito: Série 2 / The self-consciousness as subject.Roberto Horácio de Sá Pereira - 2009 - Kant E-Prints 4:229-265.


TechHQ focuses on the way small and medium enterprises use technology to grow and prosper. Our content is written for innovators, entrepreneurs, business managers, channel partners, and change makers who are passionate about technology and turning ideas into solutions.
We're constantly in touch with our audience, connecting with them everyday, helping them navigate and leverage technology to grow and scale their business.
Discipline is one of our core values; for us that means process.


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Darktrace platform enhancements provide additional vulnerability insights
Darktrace announced a new update to its flagship platform, empowering human security teams with a simplified, streamlined workflow that allows them to operate at scale under an increasingly demanding cyber security landscape.
With over 80 new features and 70 additional machine learning models, there are three main categories of upgrades:
A new UX/UI design enhancing and streamlining workflows.
Explainable AI that communicates decisions and actions in plain English.
AI capable of making micro-decisions allowing human experts to make macro-decisions.
The Enterprise Immune System, the AI detection "engine," has both significantly improved usability and a streamlined workflow. Customizable filters are now able to display threats by classification, for instance "critical" incidents or those relating to compliance. In addition, users can view model breaches based on device type to help quickly identify those in the most vulnerable position. Threat investigation displays can show model breaches according to where they fit within the MITRE ATT&CK framework and integrations with various third-party CVE providers enrich context and provide additional vulnerability insights.
Darktrace's Cyber AI Analyst product, an automated investigation technology, has also undergone changes to explain the processes behind the AI-powered analysis, investigation, and reporting all of which it does in a more comprehensive way. Cyber AI Analyst's incident display leverages a unique application of natural language processing to clearly outline the steps a human analyst would take if analyzing the same activity, and highlights a concise incident summary outlining each stage, which is easy to understand and quick to triage. It also displays events linked to a particular incident, associated users, destination ports, protocols used, as well as a full breakdown of the actions that were taken by the technology.
Antigena, Darktrace's Autonomous Response technology, has also been extended to new coverage areas within a digital enterprise, including a new configuration area for endpoint devices as well as combined SaaS and email coverage. By establishing areas of the business where Antigena can autonomously neutralize in-progress attacks in real time, without the need for human input, operators are empowered to be more strategic. Machine learning makes thousands of micro-level decisions, allowing human analysts to operate on a macro level, making the important decisions that require business context, while still maintaining full control over their environment.
"The hallmark of a great AI solution is the ability to surpass automation to seamlessly blend into users' everyday work rhythm. With the latest release of Darktrace's Enterprise Immune System, we really kept the user at the forefront of all UX/UI design decisions, from the beginning to the end of the AI product development life cycle," said Jack Stockdale OBE, CTO Darktrace. "When developing Darktrace Cyber AI products, our goal is to augment and uplift the security team to make the task at hand more efficient, so the end product is very intuitive and helps users in their workflow journeys."


Welcome to our music artist profile page.
We profile select musical artists whose recordings have stood the test of time. For each musical artist provide some background information, review their best work, and provide free sources of additional information.
We currently have profiles of the following artists.
Check this out! Seven discs. Limited edition. Sold Out!
2012 - 17 Pine Avenue is the follow-up to Where I Come From.
*Led Zeppelin is planning to re-master their albums with bonus tracks. Hopefully they will start in 2013, we'll see.
Ronnie Hawkins - Info on the albums with The Band and coming in October 2011, the albums that Duane Allman played on that were previously released in Canada.
I found this to be a very nice listen.
Jerry Garcia Collection Vol. 2 : Jerry Garcia Band (Keystone Berkeley, November 17 & 18, 1975) - Nov. 2009 Release Date - The first concert release with Nicky Hopkins in the band.
Gram Parsons - We've expanded our coverage.
David Grisman's new website Acoustic Oasis - Launched in 2010 - Check out the radio and the daily download.
Professor Louie and the Crowmatix - March 9, 2010, release of Whispering Pines on Woodstock Records.


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Our Iceberg Is Melting Book
The book you are looking for "Our Iceberg Is Melting" is available, enjoy it now. Available in PDF, Kindle and Audiobooks. You can read and download via Whatever your device, Very Fast and Easy.
Our Iceberg Is Melting
Author : John Kotter
Genre : Business & Economics
The revised and updated tenth anniversary edition of the classic, beloved business fable that has changed millions of lives in organizations around the world. Our Iceberg Is Melting is a simple story about doing well under the stress and uncertainty of rapid change. Based on the award-winning work of Harvard Business School's John Kotter, it can help you and your colleagues thrive during tough times. On an iceberg near the coast of Antarctica, group of beautiful emperor penguins live as they have for many years. Then one curious bird discovers a potentially devastating problem threatening their home—and almost no one listens to him. The characters in the story—Fred, Alice, Louis, Buddy, the Professor, and NoNo—are like people you probably recognize in your own organization, including yourself. Their tale is one of resistance to change and heroic action, seemingly intractable obstacles and clever tactics for dealing with those obstacles. The penguins offer an inspiring model as we all struggle to adapt to new circumstances. Our Iceberg Is Melting is based on John Kotter's pioneering research into the eight steps that can produce needed change in any sort of group. After finishing the story, you'll have a powerful framework for influencing your own team, no matter how big or small. This tenth anniversary edition preserves the text of the timeless story, together with new illustrations, a revised afterword, and a Q&A with the authors about the responses they've gotten over the past decade. Prepare to be both enlightened and delighted, whether you're already a fan of this classic fable or are discovering it for the first time.
Publisher : Portfolio
"First published in the United States by John Kotter and Holger Rathgeber under the title Our Iceberg Is Melting: Changing and Succeeding Under Adverse Conditions."
That S Not How We Do It Here
File Download : 0 page
What's the worst thing you can hear when you have a good idea at work? "That's not how we do it here!" In their iconic bestseller Our Iceberg Is Melting, John Kotter and Holger Rathgeber used a simple fable about penguins to explain the process of leading people through major changes. Now, ten years later, they're back with another must-read story that will help any team or organization cope with their biggest challenges and turn them into exciting opportunities. Once upon a time a clan of meerkats lived in the Kalahari, a region in southern Africa. After years of steady growth, a drought has sharply reduced the clan's resources, and deadly vulture attacks have increased. As things keep getting worse, the harmony of the clan is shattered. The executive team quarrels about possible solutions, and suggestions from frontline workers face a soul-crushing response: "That's not how we do it here!" So Nadia, a bright and adventurous meerkat, hits the road in search of new ideas to help her troubled clan. She discovers a much smaller group that operates very differently, with much more teamwork and agility. These meerkats have developed innovative solutions to find food and evade the vultures. But not everything in this small clan is as perfect as it seems at first. Can Nadia figure out how to combine the best of both worlds—a large, disciplined, well-managed clan and a small, informal, inspiring clan—before it's too late? This book distills Kotter's decades of experience and award-winning research to reveal why organizations rise and fall, and how they can rise again in the face of adversity.
Author : John P. Kotter
Publisher : Harvard Business Press
Offers advice on how to lead an organization into change, including establishing a sense of urgency, developing a vision and strategy, and generating short-term wins.
Transform your organization with speed and efficiency using this insightful new resource Incremental improvement is no longer sufficient in helping organizations navigate the complexity, uncertainty and volatility of today's world. In Change: How Organizations Achieve Hard-to-Imagine Results in Uncertain and Volatile Times, authors John P. Kotter, Vanessa Akhtar, and Gaurav Gupta explore how to create non-linear, dramatic change in your organization. You'll discover the emerging science of change that teaches us about how to build organizations – from businesses to governments – that change and adapt rapidly. In Change you'll discover: Why the ability of organizations to deal with threats and take advantage of opportunities in the face of ever greater complexity and uncertainty is being severely challenged In-depth, evidence-based, actionable solutions for dealing with institutional resistance to change Case studies and success stories that describe organizations who have successfully built the ability to change quickly into their DNA A universal approach for how to dramatically improve outcomes from various change efforts, including: strategy execution, digital transformation, restructuring, and more Perfect for managers, executives, and leaders at companies of all types and sizes, Change will also prove to be a valuable asset to other professionals who serve these organizations. This book is for anyone seeking a proven approach for delivering fast, sustainable and comprehensive results.
A Sense Of Urgency
In his international bestseller "Leading Change," Kotter provided an action plan for implementing successful transformations. Now, he shines the spotlight on the crucial first step in his framework: creating a sense of urgency by getting people to actually see and feel the need for change.
Publisher : Harvard Business Review Press
You've got a good idea. You know it could make a crucial difference for you, your organization, your community. You present it to the group, but get confounding questions, inane comments, and verbal bullets in return. Before you know what's happened, your idea is dead, shot down. You're furious. Everyone has lost: Those who would have benefited from your proposal. You. Your company. Perhaps even the country. It doesn't have to be this way, maintain John Kotter and Lorne Whitehead. In Buy-In, they reveal how to win the support your idea needs to deliver valuable results. The key? Understand the generic attack strategies that naysayers and obfuscators deploy time and time again. Then engage these adversaries with tactics tailored to each strategy. By "inviting in the lions" to critique your idea--and being prepared for them--you'll capture busy people's attention, help them grasp your proposal's value, and secure their commitment to implementing the solution. The book presents a fresh and amusing fictional narrative showing attack strategies in action. It then provides several specific counterstrategies for each basic category the authors have defined--including: · Death-by-delay: Your enemies push discussion of your idea so far into the future it's forgotten. · Confusion: They present so much data that confidence in your proposal dies. · Fearmongering: Critics catalyze irrational anxieties about your idea. · Character assassination: They slam your reputation and credibility. Smart, practical, and filled with useful advice, Buy-In equips you to anticipate and combat attacks--so your good idea makes it through to make a positive change.
Leading Change With A New Preface By The Author
The international bestseller—now with a new preface by author John Kotter. Millions worldwide have read and embraced John Kotter's ideas on change management and leadership. From the ill-fated dot-com bubble to unprecedented M&A activity to scandal, greed, and ultimately, recession—we've learned that widespread and difficult change is no longer the exception. It's the rule. Now with a new preface, this refreshed edition of the global bestseller Leading Change is more relevant than ever. John Kotter's now-legendary eight-step process for managing change with positive results has become the foundation for leaders and organizations across the globe. By outlining the process every organization must go through to achieve its goals, and by identifying where and how even top performers derail during the change process, Kotter provides a practical resource for leaders and managers charged with making change initiatives work. Leading Change is widely recognized as his seminal work and is an important precursor to his newer ideas on acceleration published in Harvard Business Review. Needed more today than at any time in the past, this bestselling business book serves as both visionary guide and practical toolkit on how to approach the difficult yet crucial work of leading change in any type of organization. Reading this highly personal book is like spending a day with the world's foremost expert on business leadership. You're sure to walk away inspired—and armed with the tools you need to inspire others. Published by Harvard Business Review Press.
Moving beyond the process of change Why is change so hard? Because in order to make any transformation successful, you must change more than just the structure and operations of an organization—you need to change people's behavior. And that is never easy. The Heart of Change is your guide to helping people think and feel differently in order to meet your shared goals. According to bestselling author and renowned leadership expert John Kotter and coauthor Dan Cohen, this focus on connecting with people's emotions is what will spark the behavior change and actions that lead to success. Now freshly designed, The Heart of Change is the engaging and essential complement to Kotter's worldwide bestseller Leading Change. Building off of Kotter's revolutionary eight-step process, this book vividly illustrates how large-scale change can work. With real-life stories of people in organizations, the authors show how teams and individuals get motivated and activated to overcome obstacles to change—and produce spectacular results. Kotter and Cohen argue that change initiatives often fail because leaders rely too exclusively on data and analysis to get buy-in from their teams instead of creatively showing or doing something that appeals to their emotions and inspires them to spring into action. They call this the see-feel-change dynamic, and it is crucial for the success of any true organizational transformation. Refreshingly clear and eminently practical, The Heart of Change is required reading for anyone facing the challenges inherent in leading change.
Describes how organizations can learn to move swiftly to accommodate change while still providing the necessary structures that nurture employees and long-term success.


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B 167 bezeichnet:
 die Bundesstraße 167 in Deutschland
 die Gasteiner Straße in Österreich

Abkürzung

redpajama_set_name: RedPajamaWikipedia


"M.A.M. (My Assyrian Mother)" is a double portrait, starting as a silent portrayal of two similarly dressed woman, obviously related, and differenced in age. Suddenly a discussion develops about the framing and their position within the image.


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Wowhappylife
All CategoriesDiet & Weight LossExercise & FitnessRemediesSupplementsWomens HealthYoga
FMI names ex-Wegmans dietitian to lead its health and wellness initiatives
Home >> Fitness >> FMI names ex-Wegmans dietitian to lead its health and wellness initiatives
June 2, 2020 By donutjam Fitness No Comments on FMI names ex-Wegmans dietitian to lead its health and wellness initiatives
The Food Industry Association (FMI) has appointed Krystal Register to lead the organization's health and well-being policy, operations and communications for FMI members, the trade association announced.
Prior to FMI, Register spent 12 years as a retail dietitian at Wegmans, where she developed and executed company wellness programs, health messaging, employee training and in-store promotions. Register participated in community events like the NBC4 Health and Fitness Expo, DC Gluten-Free Education Day and Smithsonian Food History programming. She also has experience as a media contact for nutrition-related content.
Hilary Thesmar, FMI's chief food and product safety officer and senior vice president of food safety programs, said in a statement that Register will be able to work with "seamlessly" with peers in retail dietetics and dietitians in clinics, public health, nutrition policy and the community. She said these experiences will "augment" FMI's work in representing its grocers' programs.
Grocers across the country have doubled down on their health and wellness initiatives over the past few years. FMI's decision to create this new role and hire an expert like Register to fill it signals the trend isn't slowing down anytime soon.
As grocers implement new health-related programs, FMI and Register will be able to provide members with guidance to develop, implement and evaluate these programs to best fit their company, Thesmar said in a statement. But Register's role could evolve over time. In the statement, Thesmar added that FMI will work with Register to build her role and responsibilities.
Retailers face a new challenge in developing and communicating health and wellness programs during the COVID-19 pandemic. Many have rolled out new programs that connect with shoppers at home. ShopRite began giving customers virtual access to its dietitians in March, and Kroger shoppers can schedule a video chat with a dietitian through the chain's health service. Last month, Giant Food launched a #HealthyAtHome challenge to offer health guidance to shoppers.
FMI has been tracking trends in health and wellness for years through reports like "The Power of Health and Well-Being in Food." In an FMI study last year, 90% of retailers surveyed said they have health and wellness programs in place. The report showed that retailers could do more to integrate these kinds of initiatives into their online and offline strategies. With its new health and wellness internal hire, FMI could help retailers fill this gap.
Pushing health and nutrition further through omnichannel strategies is arguably more important now than ever before. Shoppers are turning to grocery e-commerce in record numbers while at the same time trying to comply with new store safety measures. Practicing healthy habits is important to consumers as well, especially in the midst of a global pandemic.
— to www.grocerydive.com
Nations Best Deals Attributes Growth to Medical, Restaurant and Fitness Markets
Nurse Excellence Award winners announced – Dorchester Banner
September 17, 2020 donutjam
First Responders Allowed Access To Three 24 Hour Fitness Locations Near California Fire Zones For Showering, Relaxation Between Assignments
ROSEVILLE (CBS13) – Emergency responders beginning next week will have courtesy access to three area 24 Hour Fitness locations to shower and wind down before returning back to fire zones, the fitness club announced on Thursday. Beginning Monday, Sept. 21, emergency responders will have access to 24 Hour Fitness locations in Roseville (336 N. Sunrise […]
May 23, 2020 donutjam
Establish your health and wellness goals – News – The Shawnee News-Star
Life can be difficult, and is certainly too short to let complications from poor health habits get in the way. I challenge you to give it everything you've got, and not let this happen to you. Even though following good health habits is not a full proof system for living forever, it certainly makes our […]
July 25, 2020 donutjam
Fitness fans' joy as they can start pumping iron again as gyms reopen today
Gym buffs and locked-down Britons with bulging stomachs can finally pump iron again today as gyms reopen after months of lockdown. Indoor gyms and leisure centres have been among the last businesses to open their doors again to the public during the coronavirus crisis. Fitness fanatics are expected to flock to gyms across the country […]
Trending now: Fitness Equipment Market Growth, Segments, Revenue, Manufacturers & Forecast Research Report
Free activities in north-east to mark National Fitness Day
Rest days are important for fitness – this is why, according to science
BUSINESS NOTE: The Landing adapting to the pandemic | Health and Fitness
Runnin' with Rani: Kona's Winona Chen strives to be the next Ms. Health and Fitness
Welcome to My Store – This is your number one source for all products to improve you health. We're dedicated to giving you the very best of Fitness E-books, with a focus on dependability, customer service and uniqueness.
You'll find several payment methods to purchase your desired ebook from Clickbank. You can use any debit or credit card and Paypal to purchase ebooks from Clickbank.
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Jojo Fletcher is a well-known American television personality and a real estate developer. She has won many hearts with her role in the 20th series of a television show named "The Bachelor". In the show, she competed with other girls to win the heart of business analyst Ben Higgins. Read further to know more about the net worth of Jojo Fletcher in 2019.
Jojo was born on 1st of November, 1990 in Dallas, Texas, the U.S.A. as Joelle Hannah Fletcher. She was born in a doctor family where her parents Soraya Fletcher and Joseph Fletcher were both doctors by profession.
Fletcher has a half-sister and three half-brothers. She has also worked with her half-brother in an episode of Ready for Love. She earned a degree in Medical Humanities from the Baylor University, Texas.
Fletcher dealt with heartbreak when she lost The Bachelor show, as Ben chose Laura over her. Later on, when she was featured on The Bachelorette, she found love again, in Jordan Rogers, who was the winner of the show and also her fiancé.
The couple has been together since 2016 and is deeply in love with each other. When asked about marriage, Jojo has said multiple times that she is wholly committed to Jordan, and is in no hurry to marry. They are enjoying their companionship.
Fletcher first appeared on the first episode of "Ready for Love", with her half-brother, Ben Patton and then she participated as a contestant on Ben Higgins's season of "The Bachelor". Though she lost to Lauren Bushnell, she won many hearts with her appearances.
Later, in 2016, Fletcher was featured in the 12th season of "The Bachelorette" where twenty –six men had to win the heart of Fletcher. She chose Jordan Rogers as the winner of the show. Fletcher also appeared in one of the episodes of The Bachelor Winter Games where she judged a kissing contest on ABC.
Fletcher started working as the new ambassador for Marcus by Goldman Sachs, from April 2018. Recently, in June 2018, she announced her clothing line, Fletch. In September 2018, Fletcher along with her fiancé, Jordan Rodgers appeared in a Kin web series named "Engaged" with Jojo and Jordan.
Fletcher's estimated net worth is more than $1 million, achieving all that at just an age of 27. She participated in three TV shows, and also been a judge in "The Bachelor Winter Games". She will be soon seen in Engaged with Jojo and Jordan series.
Fletcher has also been into real estate development for many years. She also plans to launch her clothing, Fletch. With all these, one thing is clear that Fletcher has been successful throughout her career and has built a legacy of her own, all over the years.
Jojo Fletcher is a charming and successful young lady who is loved and appreciated by the audience very much. She will be seen soon again on the television with her fiancé Jordan Rogers and will win over hearts again.


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Q: How to fill different values in a new column based on different values of another column using dplyr? Here is my data:
a <- data.frame(x=c('A','A','A','B','B','B'),
                y=c('Yes','No','No','Yes','No','No'),
                z=c(1,2,3,4,5,6))

I want to generate a new column this way:

*

*Group by x, so all the As will be in one group and all Bs in another

*For every group, if y=Yes, then keep the z value in the new column. If y=No, then using the z value with y=Yes.

So, the new data should look like this:
x    y   z   z1
A   Yes  1   1
A   No   2   1
A   No   3   1
B   Yes  4   4
B   No   5   4
B   No   6   4

I can use this way to do:
a1 <- a %>%
   filter(y=='Yes') %>%
   distinct(x,y,z)
 a2 <- a %>%
    left_join(a1,by='x') %>%...

But in this way, I have to generate a1 as an intermediate. How to do this just in one pipeline without generating a new variable like a1 in my example?

A: You could combine both pipelines and perform the same functions in one shot.
i.e...
    a <- data.frame(x=c('A','A','A','B','B','B'),
                    y=c('Yes','No','No','Yes','No','No'),
                    z=c(1,2,3,4,5,6))

    a %>% left_join(a %>% filter(y=='Yes') %>% distinct(x,y,z), by='x') %>% select(-y.y)

This results in duplicate columns tagged with .x and .y as a result of the join.

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Q: Creating a 'tab-away' attribute Directive with AngularJS I'm asking this question off the back of:
Dynamically adding an attribute Directive to a transclude Directive in AngularJS
where it was pointed out that the way I was attempting to do something was likely the wrong way to do it. Given that I'm newish to AngularJS, I probably am.
This is what I'm looking to achieve, and how I'm going about it.
If anyone can suggest a more appropriate way - using AngularJS - I'd appreciate it.
The Initial Control/Directive
I'm creating a dropdown panel control using a transcluded directive. It has a button. When you press the button, a div will become visible. The div will contain the transcluded content. I'm fine with all of this.
Tabbing Away
I needed to add functionality so that if you tab away from the control, it closes.
First of all, I attach a 'keypress' event to the document body. This is attached when the dropdown is displayed, and removed when the dropdown is hidden. It must be added/removed at this point to avoid conflict with other instances of the directive (see Handling Click-Aways for two or more of the same directive, which discusses click away, but the scope issues also apply for keypress events).
I then check whether the control has lost focus. To do this, I check whether the directive itself, along with any of it's children has focus following a key press which is tab. The blur logic is as follows:
$scope.directiveHasLostFocus = function () {
  var dropdownWrapper = angular.element("#" + $scope.directiveId + " .dropdown-panel-wrapper");
  if (!dropdownWrapper.is(":focus") && dropdownWrapper.find(":focus").length === 0) {
    return true;
  } else {
    return false;
  }
}

This all works fine.
Refactoring
All the code for this directive is in one directive. It's growing...
I had the thought that I could extract the tab-away functionality into it's own directive.
To do that, I needed to dynamically add/remove the new tab-away directive when the dropdown panel is displayed/hidden (so the events are added/removed appropriately). And that's what led me to:
Dynamically adding an attribute Directive to a transclude Directive in AngularJS
... where I was told I am probably doing it wrong.
Can anyone suggest a better way of going about this using AngularJS? I could not extract it into it's own directive, and it would work fine. But I'm keen to extract it if I can.
Sorry it's such a vague question. I prefer to ask more focused questions, but on this occasion it has to be somewhat high level.
Many thanks.


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Older Entry 'Social Affairs' doors open to all regulatory authorities'.
Newer Entry Kuwait population on decline – Indians top exodus.
Remittance tax back in play.
- Kuwait Local News | Feb 22,2021
The attempt to impose tax on remittances continues with the bill submitted by MP Abdullah Al- Turaiji who proposed taxing the money transfers of foreigners in any currency.
The bill covers remittances of individuals, companies and organizations; excluding the exempted categories stipulated in the treaties on protecting investment and capital transfer.
The bill authorizes the Central Bank of Kuwait to specify the categories according to the amount of transfer and the corresponding tax, as well as the methods of monitoring and collecting tax.
The collected tax will be handed over to the Central Bank, while banks and licensed companies that will not remit the collected tax to the Central Bank will be fined KD 10,000 maximum.
Individuals, companies and societies that violate the law by transferring money through unaccredited exchange centers and banks will be imprisoned for five years or fined double the amount transferred. The Council of Ministers will issue the executive decree of the law within three months after its ratification.
Meanwhile, MP Hassan Jawhar asked all the interim ministers about the procedures they have adopted to strengthen cyber security. He wants to know the number of Kuwaiti and expatriate employees in every ministry who completed training course on cyber security since 2012 when the Central Agency for Information Technology (CAIT) announced the plan to train 5,000 employees from 50 ministries and public institutions.
He asked if every ministry has its own policy or all of them have adopted the unified cyber security strategy of the State, demands of each ministry in light of the international criteria for database protection, department in charge of cyber security in each ministry, if a ministry or any of its subsidiaries have a contract in this regard with a private company, if such a company is capable of transferring the national database outside the country or not, procedures taken to prevent such transfer as it exposes national security to penetration, criteria for providing cyber security, and if a neutral institution has been assigned to evaluate the level of cyber security in each ministry.
MP Mubarak Al-Arow forwarded queries to interim Minister of Oil, Electricity and Water Muhammad Abdullah Al-Fares about the settlement of tender number RFB2066003 in favor of two Egyptian companies – Sino Tharwa Drilling Company and Egyptian Drilling Company (EDC) – for KD 12.944 million while the lowest bid was KD 10.864 million. He asked if there was a recommendation to choose the abovementioned companies or not, why these two companies were not obligated to offer the lowest price especially since the quality of work and adopted criteria are the same, if the ministry is aware that Sino Tharwa Drilling Company incurred losses amounting to $33 million in 2019 and it has yet to start the works stated in tender number JOsc448/w018 which was signed with Gulf Petroleum Company in 2019 because of its problems, and if penalties were imposed on these Egyptian companies for the delayed execution of the works specified in the tender MP Mehalhal Al-Mudaf asked interim Minister of Finance Khalifa Hamada about the number of Build-Operate-Transfer (BOT) projects, which will be handed over to the State by fiscal 2022/ 2023.
He requested for copies of the reports on the operating conditions of every project, action that the ministry will take in case the projects do not meet the criteria, public institution which will monitor the projects, role of the Higher Committee for Partnership Enterprises in this regard, report of the committee on every project, and ways the State will manage the projects. MP Osama Al-Shaheen submitted questions to interim Minister of Health Dr Basel Al-Sabah about the recent decisions of the Directorate General of Civil Aviation (DGCA), such as requiring arriving passengers to undergo institutional quarantine in hotels for seven or 14 days.
Source- Arab Times.
Hailstones likely to hit Kuwait as rain continues.
UAE approves COVID-19 vaccine for health workers.
Bid to curb power theft.
Q8 Admin - Feb 9, 2021 0
Forbes Middle East lists 6 Kuwaitis among 100 most powerful CEOs – Al-Kharafi tops.
Q8 Admin - Jul 7, 2022 0
Coronavirus Kuwait Local News
Almost 60% vaccinated in Kuwait.
Q8 Admin - Jun 6, 2021 0
Municipality allocates new camping sites.
3 Expats trying to escape isolation from Mahboula arrested
Q8 Admin - Jun 13, 2020 0
18,000 Bedouns status amended in last 10 years.
MP proposal tackles parking.
Demographics and ending residence of expats above 60 yrs to break back of real estate sector.


Learn more about the business of making music, audio services, video production, and more when you drop by the Huddle Entertainment Group Inc. blog. Make sure to keep visiting our website to keep yourself in the loop on what we're up to in our studio in Phoenix, Arizona.
Contact us to for more information about our services. We look forward to working with you!


also do a lot more advanced searches - type 'man grep' for details."
вопрос, а как это сделать скриптом shell?
то есть найти сточку и закоментировать.
shell, /etc/profile, or equivalent.) The default is ``yes''.
named ``.hushlogin'' in their home directories or through login.conf(5).


text:
San José Acatempa es un municipio del departamento de Jutiapa de la región sur-oriental del país de Guatemala.

Antecedentes históricos
Se dice que los primeros habitantes del municipio fueron los descendientes de las personas que se dedicaban a la piratería ya que el color de la piel de los primeros habitantes era blanca y sus ojos eran claros. Dicen que su descendencia proviene de Hungría y luego se mezclarían con los españoles que gobernaron todo el país. En el siglo XVIII el municipio se llamaba el "El Valle de Lazacualpa" en la época colonial. No existe una fecha específica que demuestre la fundación oficial del municipio, pero por el decreto del 9 de mayo de 1854, San José Acatempa formó parte del departamento de Santa Rosa con el nombre de Azacultepa. El 22 de marzo de 1941 se declaró municipio oficial de Jutiapa bajo el gobierno del general Jorge Ubico cambiando de nombre a San José Acatempa.

Ubicación
Se encuentra entre límite del departamento de Jutiapa y al sur del departamento de Santa Rosa y es uno de los municipios más cercanos a la ciudad capital con 86 kilómetros de distancia y está a 34 kilómetros de la cabecera departamental. Se localiza entre el norte del municipio de Jalpatagua, al sur del municipio de Casillas del departamento de Santa Rosa, al este de los municipios de Cuilapa y Oratorio del departamento de Santa Rosa y a oeste de Quesada.

División territorial
Es uno de los municipios que menos aldeas tiene debido a su escasa extensión territorial, pero tiene una gran variedad de corrientes de agua, como riachuelos, quebradas y ríos, ya que tiene una zona de vida natural muy abundante. También tiene cerros en sus elevadas tierras a nivel del mar. Contiene 11 aldeas, 8 caseríos de los cuales uno está extinto conocido como El Carrizo, 40 corrientes de agua y 11 cerros que son:

Aldeas
 Llano Grande
 La Carretera
 El Carpintero
 El Copante
 Calderas
 La Ceibita
 Tunillas
 Delicias
 El Cujito
 El Pericón
 El Tablón

Caseríos
 La Cruz
 Los Llanitos
 El Llano
 Quebrada Verde
 El Valle Abajo
 Monte Redondo
 Monte Rico
 Las Vegas
 El Jute
 El chapernal

Cerros
 Cerro Nayes
 Cerro Quedepeque
 Cerro Alto
 Cerro Los Indios
 Cerro El Coyolar
 Cerro Santa Anita
 Cerro La Simona
 Cerro El Gorrión
 Cerro Huehuetepe o Huetepe
 Cerro Las Minas
 Cerro La Torre

Corrientes de agua
Tiene un total de 40 corrientes de agua que se dividen en 9 ríos, 29 quebradas y 2 riachuelos que son:

Ríos
Los ríos son la fuente más importante que tiene el municipio para sus cultivos, entre sus más importantes están el río Naranjo río Blanco, río Grande, río El Ingenio, río El Jute.

Quebradas
Hay una gran variedad de quebradas que solo se pueden mencionar las más importantes que son Quebrada Verde que nace del río Grande, Quebrada Zarca que desemboca del río Grande, Quebrada Seca que se une al río el Ingenio, El Magüey, etc.

Riachuelos
Existen dos riachuelos que provienen de los demás ríos que son riachuelo El Salto y El Rincón.

Comercio
El comercio lo ocupa la agricultura, la producción pecuaria, la artesanía y entre la producción se encuentra una gran fuente de economía del municipio.

Agricultura
El 80% del territorio lo ocupa la agricultura y es por eso que es uno de los municipios más importantes en lo que es la cosecha. Entre los cultivos más importantes están el maíz, frijol, café, maicillo, patatas y arroz.

Producción pecuaria
Los pobladores acostumbran a criar animales de corral así adquiriendo productos lácteos, carnes, huevos y muchas cosas. Entre sus ganados están el ganado vacuno, equino,  bovino, porcino y aviar.

Artesanía
También es un municipio en donde la artesanía es una fuente económica muy sobresaliente, sobre todo al venderlos a otros municipios que no acostumbran a crear objetos artesanos. Entre sus objetos artesanos están la cerámica, muebles de madera, ladrillo y teja de barro.

Enlaces externos
Mijutiapa.com

biblioteca.usac.edu.gt

Referencias

Municipios de Jutiapa


text:
Франтішек Крайняк ( 4 січня 1956, Пряшів — Соливар) — священник Словацької греко-католицької церкви, перекладач, публіцист і культурний діяч русинського середовища у Словаччині. Ініціатор перекладу релігійних текстів русинською мовою, частину яких переклав сам.

Біографія
По закінченні середньої школи у Пряшеві навчався у 1976—1981 рр. на римсько-католицькому богословському факультеті імені Кирила та Мефодія в Університеті Коменського в Братиславі, оскільки у той час Греко-католицька церква в Чехословаччині не мала власної семінарії і богослови зі Словаччини могли навчатися лише на тому факультеті в обмеженій кількості. У 1981 році отримав сан священника і короткий час служив у парафії в Рокитові коло Гуменного. У 1983 році отець Крайняк сформував групу священників і вірян, завданням якої був переклад релігійних і богослужбових текстів з церковнослов'янської мови на русинську. З 1985 року понад два десятиліття служив у парафії в Меджилабірцях.

У 1999 році отримав титул ліценціата теології.

Останні роки є парохом в русинському селі Камйонка старолюбовняньского окресу.

Переклади
Переклав русинською мовою:
 «Малый ґрекокатолицькый катехізм про русиньскы діти», 1992.
 «Євангелія на неділі і свята цілого року», 1999.
 «Євангеліє од св. Йоана», 2003.

Посилання
 П. Медвідь. Отець Франтішек Крайняк дожывать ся 60 років
 http://www.ng.ru/ng_religii/2001-09-26/5_identity.html?id_user=Y

Священики Словацької греко-католицької церкви


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text:
Crew News
Recurring and Guest Stars News
Wayward Sisters (Supernatural spin-off)
Season Twelve Episodes
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[ January 17, 2020 ] Supernatural 15×10 Promo "The Heroes' Journey"	News
[ January 13, 2020 ] Supernatural episode, 'The Gamblers,' airs January 30	Episodes
[ January 8, 2020 ] Promo Photos for Supernatural's January 16 episode, 'The Trap'	News
[ January 6, 2020 ] Supernatural episode, 'The Heroes' Journey' airs January 23 (episode synopsis)	Episodes
[ December 23, 2019 ] Supernatural episode, 'The Trap,' airs January 16 (episode synopsis)	Episodes
HomeEpisodes
Hook Man
The infamous "Hook Man," a vengeful spirit who kills his victims with a shiny hook that serves as his hand, terrorizes a small college town in Iowa. Sam (Jared Padalecki) and Dean (Jensen Ackles) learn that all the victims are connected to the daughter of a local minister and race to find and destroy the Hook Man's bones before he comes for them.… Read More
Sam (Jared Padalecki) and Dean (Jensen Ackles) come to the aid of Sam's old college buddy after he is accused of a murder he swears he didn't commit. The brothers discover a shapeshifter is adopting the likenesses of others and murdering people. The brothers' race to stop the shapeshifter takes a terrifying turn when he shifts into the likeness of Dean.… Read More
In suburban Nebraska, a group of partying high school teens jokingly dare their friend Charlie (guest star Marnette Patterson) to look into the mirror and repeat 'Bloody Mary, Bloody Mary, Bloody Mary," not knowing this will unleash a series of mysterious murders. Sam (Jared Padalecki) and Dean (Jensen Ackles) realize that Bloody Mary has the power to travel through all reflective surfaces when she is hunting a victim. Worried that teens are accidentally summoning Bloody Mary, Sam and Dean race to destroy the violent spirit before she can kill again.… Read More
Phantom Traveler
On TransNational flight 2485, a man possessed by the spirit of the Phantom Traveler causes the plane to crash, leaving only five survivors left alive. Sam (Jared Padalecki) and Dean (Jensen Ackles) must exorcise the angry spirit before it attacks the survivors. The brothers realize the only way to do that is to take the battle to the skies.… Read More
Sam (Jared Padalecki) and Dean (Jensen Ackles) investigate a series of mysterious drownings written off as suicides. They discover the spirit is an angry little boy with the power to travel through water who is taking revenge on certain town inhabitants for a dark secret buried long ago.… Read More
Sam (Jared Padalecki) and Dean (Jensen Ackles) follow the coordinates left in their father's journal and land in the middle of the woods where they investigate the disappearance of several campers. The two brothers soon learn they are dealing with a Wendigo, a creature made famous in Native America legends. A Wendigo is a former human whose cannibalism has transformed him into a creature with superhuman strength and speed that feasts on human flesh.
Two brothers, Sam (Jared Padalecki, "Gilmore Girls") and Dean Winchester (Jensen Ackles, "Smallville"), witness their mother's paranormal death as children and grow up trained to fight by a distraught father who wants nothing more than to hunt down the thing that killed his wife. Sam escapes to college to start a new, normal life, but gets pulled back in after Dean shows up on his doorstep to tell him their father is missing. Following clues from their father's eerie phone message, the boys travel to a small town and encounter a violent and vengeful spirit called the "Woman in White."… Read More
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text:
Acid Storm (Warrior)
Bludgeon (1-Step)
Bumblebee (Deluxe)
Bumblebee (Scout)
Bumblebee (Spark Armor with Ocean Storm)
Bumblebee (Warrior)
Bumblebee (Warrior, 2020)
Cheetor (Deluxe)
Clobber (Ultra)
Gnaw (Warrior Class)
Grimlock (Scout)
Grimlock (Ultimate)
Grimlock (Ultra)
Hammerbyte (Warrior)
Hot Rod (1-Step)
Hot Rod (Warrior)
Hot Rod (Warrior, Stealth)
Megatron (1-Step)
Megatron (1-Step, 2019)
Megatron (Deluxe)
Megatron (Scout)
Megatron (Ultimate)
Megatron (Warrior)
Meteorfire
Optimus Prime (1-Step)
Optimus Prime (1-Step, 2019)
Optimus Prime (Deluxe)
Optimus Prime (Ultimate)
Optimus Prime (Ultra)
Optimus Prime (Warrior)
Optimus Prime (Warrior, Battle Base)
Optimus Prime (Warrior, Mega Axe)
Prowl (Warrior)
Repugnus (1-Step)
Scraplet
Shadow Striker (Ultra)
Shockwave (1-Step)
Shockwave (Deluxe)
Shockwave (Spark Armor with Solar Shot)
Shockwave (Ultra)
Shockwave (Warrior)
Sky-Byte (Spark Armor with Driller Drive)
Slipstream (Ultra)
Slipstream (Warrior)
Soundwave (Warrior)
Starscream (Scout)
Starscream (Ultra)
Starscream (Warrior)
Starscream (Warrior, Cybertronian)
Thundercracker (Warrior)
Volcanicus (Ultimate)
Wheeljack (1-Step)
Whirl (1-Step)
Windblade (Scout)
Windblade (Warrior)
"Cyberverse" Toy Review Index
"Cyberverse" Warrior Class Windblade Toy Review
Price Point: $14.99 (Varies by retailer)
Retailer: General Release (Target, Walmart, Amazon etc.)
*Images and text below from Amazon.com:
"Picture this: me, on Earth, still cooler than everyone this side of Optimus Prime, but I've got zero memories. Now I'm on a mission to recover my memories and discover all of my awesome powers. I'll have to battle Decepticons, outrun an explosion or two, and be heroic- basically, I'm in for one epic ride across the Cyberverse." -Bumblebee
The resourceful Windblade uses her telepathic Cityspeaker powers to defend justice with the heroic Autobots. Convert and attack with Transformers Cyberverse Action Attackers! Change figure from vehicle to robot mode in 7 steps. The last step of conversion automatically activates Windblade figure's signature Cyclone Strike Action Attack move! Once converted, attack move can be repeated through easy reactivation steps.
Look for other Action Attackers figures, each sold separately, to discover the signature attack moves of favorite Cyberverse characters! Transformers and all related characters are trademarks of Hasbro.
In late 2017 it was revealed that a new Transformers cartoon would be replacing "Robots in Disguise". The series focuses on Bumblebee with partial amnesia attempting to regain his memories. A blend of G1 and modern characters combined with a more kid-friendly animation style results in a show that leans more towards a younger audience than even "Robots in Disguise", something which is reflected in the toy line. The toy line was released in countries outside the United States such as Australia around late June 2018. A few weeks later it would be released in North America.
Among the first waves of figures released were the Warrior Class figures. The Warrior Class was first introduced in "Robots in Disguise" as a sort of compromise between the more complex Deluxe Class figures from "Generations" and the simpler figures offered throughout the rest of the "Robots in Disguise" line. This "new" Warrior Class assortment however is not a continuation of that Class of figure despite sharing the same name. Instead, these figures are more akin to the "Power Attackers" from "Age of Extinction" such as Drift focusing on a single action feature or gimmick with some detail that you would have expected from a past Warrior Class figure.
Warrior Class "Cyberverse" figures are packaged on bubble cards. The cards have a new design which takes cues from more recent Transformers packaging. There is still a vertical "Transformers" logo on the right side, above it is a symbol (Autobot or Decepticon based on the character) and the character art is at the top of the packaging with the "Cyberverse" logo under it. Perhaps the most distinctive part of the packaging design are the colors, which utilize yellow and light blue helping them stand out against the black and red colors used for "Generations" packaging on shelves. The back of the packaging features the figure with its action feature called out. In Windblade's case she is shown in both modes with a "7 step transformation" and there is a callout for her "Cyclone Strike Action Attack".
The insert on the packaging notes a recommended age of "6+" which is important to keep in mind with this Class of figure. Contrast that with a "Generations" Deluxe (such as Jazz or Sunstreaker) which have recommended ages of 8+. This age recommendation is more along the lines of "Robots in Disguise" Legion Class figures such as Bisk. This partly explains the slightly more simplified transformation.
Windblade was a "Fan Made" character based on votes taken online years ago. Since then, the character has gone on to be featured in the "Prime Wars Trilogy" cartoon and "Robots in Disguise". Now in "Cyberverse" she is a lead character, helping Bumblebee recover his lost memories. Her appearance in the cartoon is heavily based on her previous incarnations. This includes having a head design based on the Onna Bugeisha from feudal Japan. Her body design includes large shoulder armor, a thin waist area and legs which are slightly exaggerated in size. She also has wings on her back with prominent hover fans in the middle. While her poportions are different than previous versions, this figure is immediately identifiable as Windblade.
This figure is cast in metallic red and black plastic. Most of the figure is red, matching the animation model in the show. White, red, yellow and light blue paint are used on the head to provide a nice amount of detailing. The light blue is also used on the rest of the body including the chest and knees. My favorite detail are a series of mechanical looking lines on the wings that are painted blue. It looks like the wings are lighting up with energy and I love that effect on any Transformers figure. There is a small Autobot symbol on the chest. From a deco standpoint she looks great considering how relatively simple the decos in "Cyberverse" have been.
There are eleven points of articulation on this figure. This includes three in each arm and two in each leg. This is a bit disappointing at this size class (in contrast "Robots in Disguise" Windblade had fourteen. Oddly, she does not have head articulation even though it could have easily been built in without interfering with the transformation. Sadly, Windblade has no accessories, which is a shame because her sword and hover fans are shown as major parts of her personal arsenal in the cartoon. That said, she does have the "Cyclone" attack feature. Push the wings up and down and it exposes the light blue parts and the hover fans spin. It is neat, no doubt, but it is not a replacement for true accessories. That said, her hands are designed to be able to hold swords from other Windblade figures.
Transformation to Vehicle Mode:
Straighten out the arms and legs.
On the back flip out the black panel, then swing the cockpit section over the robot head and swing the black panel back into place.
Push each robot foot up.
Push the robot legs together.
Rotate the waist section around.
Swing the lower legs over the thighs.
Attach the tabs on the forearms into the slots on the hips. There are also openings on the sides of the lower legs to fit Windblade's thumbs.
Windblade's vehicle mode matches up nicely with her animation model. This includes a relatively thick nosecone section, wings with the hover fans in the center and both vertical and horizontal stabilizers in the back. It is a cool looking jet, but it lacks some of the ability of previous versions such as the hover fans being able to move.
This mode has a nice combination of colors. Red and black is one of my favorite color combos with Transformers figures so I always dig it on a figure like this. Blue and light blue on the top help offer some nice color contrast as well. I would have liked a bit more deco say, on the hover fans but overall it looks good.
"Cyberverse" Warrior Class Windblade is a good figure. And by that I mean she just skirts the edge of "good". She's not great and there is wasted potential with the lack of accessories and oddly sacrificed head articulation. If you can get this figure on sale (it was about $9 on Amazon as of this writing) then it is worth it. I would avoid paying full price if you can.
Nice sculpt that is show accurate and pays homage to previous versions of the character.
Deco in robot mode is very nice.
The "Cyclone Attack" is a neat and unique feature.
Very strange choice in removing the head articulation.
Limited articulation for a figure of this size and price point.
No accessories.
Warrior Class


text:
Acute Myeloid Leukemia - Episode 10
Case 3: IDH2-Mutated AML
EP. 1: Case 1: FLT3+ AML
EP. 2: Case 1: Allelic Burden in FLT3+ AML
EP. 3: Case 1: Treatment Recommendations for FLT3+ AML
EP. 4: Case 1: Targeted Therapy in FLT3+ AML
EP. 5: Case 2: AML With Myelodysplasia-Related Changes
EP. 6: Case 2: CPX-351 Treatment for AML With MRC
EP. 7: Case 2: Selecting a Targeted Therapy for AML With MRC
EP. 8: Case 2: CPX-351 Trial Data in AML
EP. 9: Case 2: Novel Therapies for AML With MRC
EP. 10: Case 3: IDH2-Mutated AML
EP. 11: Case 3: Targeting IDH in AML
EP. 12: Case 3: IDH Inhibitors for the Treatment of AML
EP. 13: Case 4: High-Risk de novo AML
EP. 14: Case 4: Treating AML With HMA/Venetoclax
EP. 15: Case 4: Observations of HMA/Venetoclax in Trials
EP. 16: Case 4: Additional Considerations in High-Risk de novo AML
EXPERT PERSPECTIVE VIRTUAL TUMOR BOARD
Naval G. Daver, MD:Moving on to our third case, this is anIDH2-mutated acute myeloid leukemia [AML], and I'm going to ask Dr Gergis to discuss the case, please.
Usama Gergis, MD, MBA:Thank you very much. I think it's very timely to discussIDH2and acute myeloid leukemia. Our case today is a 65-year-old woman who presented with some bruising and fatigue, and she's very fit—much better than most of us around the table. She walks 3 miles every day. She has a past medical history of hypercholesterolemia that is controlled. She presents with pancytopenia, white [blood] count [WBC] of 2.8, hemoglobin of 9, and platelets of 40,000. She now is diagnosed with acute myeloid leukemia—blast percentage 48%, cytogenetics are diploid, next-generation sequencing mutations inIDH2,GATA2, andECH2.
She was appropriately treated with 7+3 [cytarabine/daunorubicin]. Treatment course was complicated, as expected, by mucositis and febrile neutropenia. After resolution of her complications, she received 2 cycles of high dose Ara-C consolidation. In the midst of her consolidation 6 months after initial diagnosis, she presented with fatigue, body ache, and gum bleeding. She was pancytopenic—WBC 1.8, hemoglobin 8, and platelets 28,000—and she had circulating myeloblasts. The bone marrow biopsy was hypercellular with 80% blasts and normal cytogenetics. Next-generation sequencing was done again on relapse, and she has the sameIDH2,but now she hasRUNX1andDNMT3A.
Naval G. Daver, MD:Well, thank you very much. We're moving now more into the pure targeted therapies and salvage, which is where a lot of these drugs are initially getting approval. ForIDH1/2, we have gilteritinib, recently, and others in review like quizartinib. Dr Weinberg, for the molecular testing, are you routinely seeing people check this in the relapsed setting? If they are, are they asking for targeted panels or are you repeating the whole panel? What do you do?
Olga K. Weinberg, MD:Yes, we run the same panel.
Naval G. Daver, MD:Same panel, OK.
Olga K. Weinberg, MD:It is approved in a relapse setting. It's not approved in a day 30 kind of setting, so we don't use it there.
Naval G. Daver, MD:Not in remission.
Olga K. Weinberg, MD:Our panel is not really meant to be a minimal residual disease [MRD] panel. There are other panels that you can use for that, but we don't run those.
Naval G. Daver, MD:Since you brought it up, minimal residual disease, now we're going to stop for 1 hour and discuss this. I'm not going to do that, but I would just like to ask, clinically, does anybody use MRD in treatment decision-making today? At what time point do you use it and for what? James?
James K. McCloskey II, MD:I think we use MRD mostly for risk stratification. We do MRD testing at the time of first remission. We do MRD testing before they proceed to transplant and then subsequently every 3 months from the peripheral blood. I think that everyone will probably comment on this. There are a lot of variables right now in terms of how we measure MRD and how we reliably interpret it even as 1 patient might have different results, depending on the laboratory or depending on the particular aspirate that we send. There's a lot of variability, and in general, we do not alter treatment based on the MRD response at this time. I do think it adds something in terms of risk stratification and it is incorporated into some of our clinical trials.
Naval G. Daver, MD:Anything different, Dr Rizzieri, that you do with MRD?
David Alan Rizzieri, MD:I do it so I can understand if it's going to interrupt my sleep pattern at night, like you said. We know when to worry. It doesn't necessarily mean that I'm going to jump and offer an allotransplant sooner rather than later, though I'm inclined to have that discussion concerning that issue. You can see if Usama agrees.
Naval G. Daver, MD:What do you think? You use it at transplant?
Usama Gergis, MD, MBA:Sure.
Naval G. Daver, MD:Let's say somebody is low MRD-positive. What is your discussion, as a leukemia doctor?
Usama Gergis, MD, MBA:It's a tough discussion because a patient like this, at 65 years old, should come to transplant in CR1 [first complete remission]. Now, with the decision tree, we prefer if she's MRD-negative. If it's MRD-positive coming to transplant, the survival rate is in the range of 20%. That doubles if she's MRD-negative. Transplant does not offer that much for MRD-positive patients. We talk to our leukemia colleagues, and you can only do too much, and sometimes your patient's still MRD-positive after 2, 3, 4 cycles of chemotherapy. Then we have to bite the bullet and transplant, and be more vigilant with MRD monitoring after transplant. How does that really help? You reduce immune suppressive agents and cause more graft versus host disease. You get into another black hole.
Naval G. Daver, MD:Right. I think it will emerge with time. The big thing missing right now is a drug that will alter MRD, and while doing that, also alter the biology and the outcome of the disease. All of us are very familiar and happy about blinatumomab in ALL [acute lymphocytic leukemia], which is able to eradicate MRD, plus give you 3-year EFS [event-free survival] of 80%. I think in AML, we don't have that. I kind of agree with Dr Rizzieri's statement. It's like a red light. It's bad, but we don't know what to do with that. It's bad if you go to transplant; it's bad if you don't. It's been a difficult situation. We won't go into detailed discussion.


How Can I Enforce a Foreign Judgment in Australia by Common Law?
If a foreign court has made a final judgment in your favour against an Australian debtor, you may be thinking about enforcing that judgment in Australia. One way you can do this is through common law enforcement. You will need to satisfy an Australian court that you meet four criteria in order for them to enforce a foreign judgment. This article explains each of these criteria in more detail.
In order to enforce a foreign judgment, an Australian court must recognise the international jurisdiction exercised by the foreign court. Jurisdiction means that the foreign court had the authority to make a decision in your matter.
The table below outlines three factors that may indicate international jurisdiction, with accompanying examples. The examples are based on a hypothetical scenario where an Australian court is considering enforcing a Canadian court's judgment.
submitting to the court's jurisdiction.
has signed a loan contract with you that states that a Canadian court has jurisdiction to settle contractual disputes.
A foreign judgment must be final for an Australian court to consider enforcing it.
A 'final' judgment means that the foreign court has conclusively determined the issues in the judgment. It is different to an interlocutory order, where a court makes temporary orders that operate until a hearing (at which point the court will make final orders).
'Final' does not mean that there are no avenues for appeal available. Nor does it refer to the fact that no appeal has been made.
The parties in the Australian court proceedings must be the same as the parties to the foreign judgment.
However, this does not mean that in cases with multiple defendants, all defendants specified in the foreign judgment must also be defendants in the Australian enforcement proceedings. This is for practical reasons: some of the defendants may be located outside of Australia.
Additionally, the judgment is only enforceable in Australia to the extent that the debt remains unsatisfied. This means that you cannot 'double dip' and receive more money than what is actually outstanding.
the foreign judgment must be for a fixed sum.
If you need legal advice to figure out what foreign enforcement options are available to you, get in touch with LegalVision's debt recovery lawyers on 1300 544 755, or fill out the form on this page.
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