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The Embryo Project Encyclopedia
Recording and contextualizing the science of embryos, development, and reproduction.
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Displaying 51 - 75 of 698 items.
John Bertrand Gurdon (1933- )
Sir John Bertrand Gurdon further developed nuclear transplantation, the technique used to clone organisms and to create stem cells, while working in Britain in the second half of the twentieth century. Gurdon's research built on the work of Thomas King and Robert Briggs in the United States, who in 1952 published findings that indicated that scientists could take a nucleus from an early embryonic cell and successfully transfer it into an unfertilized and enucleated egg cell.
Format: Articles
Subject: People
California Proposition 71 (2004)
The California Stem Cell Research and Cures Act, also called Proposition 71, was a ballot
initiative proposed by California voters in 2004 to allocate three billion dollars of state
funds for stem cell research over ten years. Endorsed by California scientists and
patient-advocates, Prop 71 passed on 2 November 2004, amending the state constitution to make
stem cell research a constitutional right. In addition, Prop 71 led to the creation of the
California Institute for Regenerative Medicine (CIRM), in San Francisco, California to allocate
Subject: Legal
ABO Blood Type Identification and Forensic Science (1900-1960)
The use of blood in forensic analysis is a method for identifying individuals suspected of committing some kinds of crimes. Paul Uhlenhuth and Karl Landsteiner, two scientists working separately in Germany in the early twentieth century, showed that there are differences in blood between individuals. Uhlenhuth developed a technique to identify the existence of antibodies, and Landsteiner and his students showed that humans had distinctly different blood types called A, B, AB, and O.
Subject: Theories, Legal, Technologies
William Thornton Mustard (1914-1987)
William Thornton Mustard was a surgeon in Canada during the twentieth century who developed surgical techniques to treat children who had congenital heart defects. Mustard has two surgeries named after him, both of which he helped to develop. The first of these surgeries replaces damaged or paralyzed muscles in individuals who have polio, a virus that can cause paralysis. The other technique corrects a condition called the transposition of the great arteries (TGA) that is noticed at birth.
Subject: People, Disorders, Disorders
San Diego Zoo Institute for Conservation Research
The San Diego Zoo Institute for Conservation Research (SDZICR) in San Diego, California, is a research organization that works to generate, use, and share information for the conservation of wildlife and their habitats. In 1975, Kurt Benirschke, a researcher at the University of California, San Diego (UCSD) who studied human and animal reproduction, and Charles Bieler, the director of the San Diego Zoo, collaborated to form the Center for Reproduction of Endangered Species (CRES).
Subject: Organizations
Mesenchyme is a type of animal tissue comprised of loose cells embedded in a mesh of proteins and fluid, called the extracellular matrix. The loose, fluid nature of mesenchyme allows its cells to migrate easily and play a crucial role in the origin and development of morphological structures during the embryonic and fetal stages of animal life. Mesenchyme directly gives rise to most of the body's connective tissues, from bones and cartilage to the lymphatic and circulatory systems.
Subject: Processes
Exchange Transfusion for Jaundiced Newborns in the United States
Exchange transfusion is the replacement of blood from newborn infants with elevated bilirubin level in their blood stream with donor blood containing normal bilirubin levels. Newborn infants that experience jaundice, the yellowing of the skin and eyes, have a buildup of bilirubin, a chemical that occurs during red blood cell breakdown, or hemolysis. Exchange transfusion is a therapy developed throughout the 1940s by Louis Diamond and a group of surgeons at the Children's Medical Center in Boston, Massachusetts.
Subject: Technologies
Keith Henry Stockman Campbell (1954-2012)
Keith Henry Stockman Campbell studied embryo growth and cell differentiation during the twentieth and twenty-first centuries in the UK. In 1995, Campbell and his scientific team used cells grown and differentiated in a laboratory to clone sheep for the first time. They named these two sheep Megan and Morag. Campbell and his team also cloned a sheep from adult cells in 1996, which they named Dolly. Dolly was the first mammal cloned from specialized adult (somatic) cells with the technique of somatic cell nuclear transfer (SCNT).
Robert Alan Good (1922-2003)
Robert Alan Good was an American physician and scientific researcher who explored the cellular mechanisms of immunity. His research and discoveries earned him the label of "father of modern immunology." Though his work in immunology is considered his greatest scientific achievement, Good is also well known for his work with tissue engineering. From his research on immunology, Good was able to perform the first successful allogeneic (donor and recipient are unrelated) bone marrow transplant.
Somatic Cell Nuclear Transfer in Mammals (1938-2013)
In the second half of the
twentieth century, scientists learned how to clone organisms in some
species of mammals. Scientists have applied somatic cell nuclear transfer to clone human and
mammalian embryos as a means to produce stem cells for laboratory
and medical use. Somatic cell nuclear transfer (SCNT) is a technology applied in cloning, stem cell
research and regenerative medicine. Somatic cells are cells that
have gone through the differentiation process and are not germ
cells. Somatic cells donate their nuclei, which scientists
Subject: Theories, Technologies, Processes
The First Successful Cloning of a Gaur (2000), by Advanced Cell Technology
Advanced Cell Technology (ACT), a stem cell biotechnology company in Worcester, Massachusetts, showed the potential for cloning to contribute to conservation efforts. In 2000 ACT researchers in the United States cloned a gaur (Bos gaurus), an Asian ox with a then declining wild population. The researchers used cryopreserved gaur skin cells combined with an embryo of a domestic cow (Bos taurus). A domestic cow also served as the surrogate for the developing gaur clone.
Subject: Experiments
Intraspecies Chimeras Produced in Laboratory Settings (1960-1975)
When cells-but not DNA-from two or more genetically distinct individuals combine to form a new individual, the result is called a chimera. Though chimeras occasionally occur in nature, scientists have produced chimeras in a laboratory setting since the 1960s. During the creation of a chimera, the DNA molecules do not exchange genetic material (recombine), unlike in sexual reproduction or in hybrid organisms, which result from genetic material exchanged between two different species. A chimera instead contains discrete cell populations with two unique sets of parental genes.
Subject: Organisms, Processes
Using Digital PCR to Detect Fetal Chromosomal Aneuploidy in Maternal Blood (2007)
In 2007, Dennis Lo and his colleagues used digital polymerase chain reaction or PCR to detect trisomy 21 in maternal blood, validating the method as a means to detect fetal chromosomal aneuploidies, or an abnormal number of chromosomes in a cell. The team conducted their research at the Chinese University of Hong Kong in Hong Kong, Hong Kong, and at the Boston University in Boston, Massachusetts.
Frank Rattray Lillie (1870-1947)
Frank R. Lillie was born in Toronto, Canada, on 27 June 1870. His mother was Emily Ann Rattray and his father was George Waddell Little, an accountant and co-owner of a wholesale drug company. While in high school Lillie took up interests in entomology and paleontology but went to the University of Toronto with the aim of studying ministry. He slowly became disillusioned with this career choice and decided to major in the natural sciences. It was during his senior year that he developed his lifelong interest in embryology.
Gene Transfer Strategy Used to Treat Tay - Sachs Disease (2005), by Sabata Martino's Research Group
In the early 2000s, Sabata Martino and a team of researchers in Italy and Germany showed that they could reduce the symptoms of Tay-Sachs in afflicted mice by injecting them with a virus that infected their cells with a gene they lacked. Tay-Sachs disease is a fatal degenerative disorder that occurs in infants and causes rapid motor and mental impairment, leading to death at the ages of three to five. In gene therapy, researchers insert normal genes into cells that have missing or defective genes in order to correct genetic disorders.
Seed Banking 1979-1994
In the early twentieth century, scientists and agriculturalists collected plants in greenhouses, botanical gardens, and fields. Seed collection efforts in the twentieth century coincided with the professionalization of plant breeding. When scientists became concerned over the loss of plant genetic diversity due to the expansion of a few agricultural crops around mid-century, countries and organizations created seed banks for long-term seed storage.
Nuclear Transplantation
Nuclear transplantation is a method in which the nucleus of a donor cell is relocated to a target cell that has had its nucleus removed (enucleated). Nuclear transplantation has allowed experimental embryologists to manipulate the development of an organism and to study the potential of the nucleus to direct development. Nuclear transplantation, as it was first called, was later referred to as somatic nuclear transfer or cloning.
Shoukhrat Mitalipov and Masahito Tachibana's Mitochondrial Gene Replacement in Primate Offspring and Embryonic Stem Cells (2009)
Shoukhrat Mitalipov, Masahito Tachibana, and their team of researchers replaced the mitochondrial genes of primate embryonic stem cells via spindle transfer. Spindle replacement, also called spindle transfer, is the process of removing the genetic material found in the nucleus of one egg cell, or oocyte, and placing it in another egg that had its nucleus removed. Mitochondria are organelles found in all cells and contain some of the cell's genetic material. Mutations in the mitochondrial DNA can lead to neurodegenerative and muscle diseases.
Effect of Prenatal Alcohol Exposure on Radial Glial Cells
Prenatal alcohol (ethanol) exposure can have dramatic effects on the development of the central nervous system (CNS), including morphological abnormalities and an overall reduction in white matter of the brain. The impact of ethanol on neural stem cells such as radial glia (RG) has proven to be a significant cause of these defects, interfering with the creation and migration of neurons and glial cells during development.
Subject: Disorders, Reproduction
Interspecies SCNT-derived Humanesque Blastocysts
Since the 1950s, scientists have developed interspecies blastocysts in laboratory settings, but not until the 1990s did proposals emerge to engineer interspecies blastocysts that contained human genetic or cellular material. Even if these embryos were not permitted to mature to fetal stages, their ethical and political status became debated within nations attempting to use them for research.
Subject: Theories
Telomeres and Telomerase in Cellular Aging (Senescence)
Telomeres are sequences of DNA on the ends of chromosomes that protect chromosomes from sticking to each other or tangling, which could cause irregularities in normal DNA functions. As cells replicate, telomeres shorten at the end of chromosomes, which correlates to senescence or cellular aging. Integral to this process is telomerase, which is an enzyme that repairs telomeres and is present in various cells in the human body, especially during human growth and development.
Alexis Carrel's Immortal Chick Heart Tissue Cultures (1912-1946)
In an effort to develop tissue culture techniques for long-term tissue cultivation, French surgeon and biologist Alexis Carrel, and his associates, produced and maintained a series of chick heart tissue cultures at the Rockefeller Institute in New York City. From 1912 to 1946, this series of chick heart tissue cultures remained alive and dividing. Since the duration of this culture greatly exceeded the normal chick life span, the cells were deemed immortal.
Robert Lanza (1956- )
During the twentieth and twenty-first centuries, Robert Paul Lanza studied embryonic stem cells, tissues,
and endangered species as chief scientific officer of Advanced Cell
Technology, Incorporated in Worcester, Massachusetts. Lanza's team cloned
the endangered species of gaur Bos gaurus.
Although the gaur did not survive long, Lanza successfully cloned
another cow-like creature, called the banteng
(Bos
javanicus). Lanza also worked on cloning human embryos
to harvest stem cells, which could be used to treat dieases. While
Hypertensive Disorders in Pregnancy (1978), by Leon Chesley
Leon Chesley published Hypertensive Disorders in Pregnancy in 1978 to outline major and common complications that occur during pregnancy and manifest in abnormally high blood pressures in pregnant women. The book was published by Appleton-Century-Crofts in New York, New York. Chesley compiled his book as a tool for practicing obstetricians and teachers.
Subject: Publications
Hydrocephalus During Infancy
Hydrocephalus is a congenital or acquired disorder characterized by the abnormal accumulation of cerebrospinal fluid within the cavities of the brain, called ventricles. The accumulation of cerebrospinal fluid, the clear fluid surrounding the brain and spinal cord, causes an abnormal widening of the ventricles. The widening creates potentially harmful pressure on the tissues of the brain that can result in brain damage or death.
Subject: Disorders
© 2019 Arizona Board of Regents
The Embryo Project at Arizona State University, 1711 South Rural Road, Tempe Arizona 85287, United States


The Interfaith Hospitality Network is an organization that unites the religious community in an effort to serve and nurture homeless families regardless of income and family structure. Twenty-six congregations, many with assistance from additional congregations, provide meals, shelter and hospitality. Families receive case management, assistance with housing and employment search, accessing support services and advocacy at the IHN day center.


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Demystifying the golden thread
Published On: February 25th, 2022Categories: White-papers23.2 min read
In this white paper, we will look at what we know so far about the golden thread and offer advice on what organisations can be doing now to prepare themselves for the changes ahead.
What you will learn from this white paper:
What is the Golden Thread and who is affected by it
What clients, consultants and contractors need to do to get ready
How building owners will be impacted
Dame Judith Hackitt's recommendations and the Building Safety Bill
Download Golden Thread White Paper
To this day, I vividly remember how as a Computer Science graduate working with Arup all those years ago I was genuinely shocked to learn that there is a big difference between as designed; as-built; and as is representation of a construction project.
A common reason for the discrepancies between the design and the status quo is "value engineering". If I was to explain this to a layperson with a bit of a hyperbole, I would say they shall imagine a famous architect specifying their brand new building with a gold plated facade, only for the contractor to render the exterior in yellow paint, claiming the end result is more or less the same – albeit significantly cheaper! Such a deviation from the original design – the gold plating having a symbolic meaning here – is often celebrated as a great cost saving service that is provided for the benefit of the client. However, we can all imagine a few
problems this can lead to. For one, you would not need to treat a gold plated facade every year, unlike say a painted surface.
These types of design and cost-led changes can be annoying and somewhat damaging to the reputation of the industry, but the real issues come when these changes directly impact the health and wellbeing of the people who build, maintain and use the assets we create.
Digital handover and transparency in decision-making might seem like a sure enough answer to all such problems. Yet, even with the best intentions, those can be badly executed. A case in point would be the new build I moved into a few years back. There, each flat came with a set of manuals both in printed form as well as on a USB stick. All in all, an eclectic mix of countless files that were badly named, impossible to search and I am pretty sure a few were missing, too.
In this white paper, we therefore set out to explain these deeply rooted issues and offer several ways of managing proper data flow, to not only offer post-build auditability and accountability, but also greater collaboration during the process to avoid the issues altogether. Hopefully, you will realise, as we have, that there is more than one way to skin the proverbial golden cat.
Dr Jozef Doboš CEng
Founder and CEO, 3D Repo
It's coming…
There are many reasons for changes to be made to elements of a building's design during its construction. At tender stage, there can be different interpretations of the design and performance specifications, and during construction, changes can occur due to the client changing scope, logistics or supply problems, detailing or interfaces that don't quite work, 'value engineering' or insolvency.
The problem comes when these changes – and the reason for them – are not properly recorded and approved. The building owner can be left with gaps in the information about their asset which will make maintenance and replacement more challenging. And, as the Grenfell Tower fire illustrated, changes that adversely affect the structural or fire safety of a building can be catastrophic.
This is why we need the golden thread of information, a concept introduced by Dame Judith Hackitt in her report that followed on from the Grenfell Tower fire: a clear way to digitally record, store and hand over all the information needed to allow a building to be safely used and operated in the future. Visit 3drepo.com to read white paper: Digitising Health and Safety.
Few people would argue with Hackitt. However, as we wait for secondary legislation, following on from the Building Safety Bill, uncertainties how the industry will deliver its golden threads remain.
A survey¹ of 906 professionals from the built environment about digital construction, published in October 2021 by the NBS, found that 49% of those surveyed were not clear on how they would manage information to play their part in delivering the golden thread. However, there was a strong recognition that digital tools were vital: 78% agreed that they needed to be working digitally to deliver the golden thread and 70% agreed that it was necessary to adopt BIM.
Aside from uncertainty about detail, there are hurdles to overcome, not least the contractual environment in which projects are procured. In a survey² of 156 professionals by i3PT Certification and the Chartered Institute of Building (CIOB), published in December 2020, 75% of respondents identified culture as the biggest blocker to implementing the golden thread.
What is certain is that the golden thread is coming – and that it won't always be limited to highrise residential buildings. In this white paper, we will look at what we know so far about the golden thread and offer advice on what organisations can be doing now to prepare themselves for the changes ahead.
Where did the golden thread come from?
Although the term 'golden thread' is used in other sectors and scenarios, it did not feature in the construction lexicon until December 2017 when Dame Judith Hackitt mentioned it in her interim report³ following the Grenfell Tower fire.
Regulations and Fire Safety4, reinforced that message.
Hackitt's recommendations went on to inform the Building Safety Bill, which was published in draft form in July 2020 and then presented to parliament on 29 June 2021. The Bill mandates that fire and structural safety information should be held digitally to specific standards which will include the need for robust information management.
Although, for now, the Bill and hence the requirement for a golden thread applies only to high-rise residential buildings, hospitals and care homes there is a clear intent that its use will widen. Schools and educational premises, conference centres and arenas, or any publicly procured buildings could be next.
The Building Safety Bill is expected to achieve Royal Assent between April and July 2022, with implementation following on in the 12-to-18 months after that – as early as April 2023. However, obligations linked to planning have already come into force.
The golden thread is also referenced in the Government's construction procurement handbook, the Construction Playbook5, which was published in December 2020 and is mandatory for all central government departments and arms-length bodies. The Playbook requires that projects apply the UK BIM Framework6, to achieve better outcomes and to help implement the golden thread.
The UK BIM Framework is a 'live' explanation of how the UK and international standards linked to BIM – effectively managing building information – should be applied in the UK. Updated regularly, it encompasses the ISO 19650 series, the current BS/PAS 1192 series and the BS 8536 series, along with related guidance. It is likely to feature in the expected Government guidance on how to manage golden thread information.
"There needs to be a golden thread for all complex and high-risk building projects so that the original design intent is preserved and recorded, and any changes go through a formal review process involving people who are competent and who understand the key features of the design."
Dame Judith Hackitt, December 2017
What is the golden thread?
"The golden thread is both the information that allows you to understand a building and the steps needed to keep both the building and people safe, now and in the future."
On 21 July 2021 the Building Regulations Advisory Committee (BRAC) published a report7 which sets out what is meant by the golden thread, in short defining it thus the above quote. In other words, it encompasses both the information and how it is used and managed. A longer, seven-point definition in the report provides further detail (see 'Golden thread at a glance').
The goal is that the person who is given responsibility for the safety of the building – with respect to both fire and structure – will have all the information they need in an accessible digital format. That information should provide evidence that all the relevant risk assessments, certification and safety checks have taken place.
Initially, the golden thread will apply to those buildings covered by the Building Safety Bill. That is buildings that are 18m or seven storeys and higher containing two or more residential units and care homes and hospitals above the same height thresholds. While the golden thread will be required during design, construction and operation for residential buildings, it only applies during the design and construction phases for care homes and hospitals. For these buildings, it is likely that the golden thread will be passed to the responsible person under the Regulatory Reform (Fire Safety) Order 2005, but this policy has yet to be confirmed8.
The Building Safety Bill sets out what the duty-holder roles will be under the new regime. During construction and refurbishment, duty holders will be the client, the principal designer and the principal contractor (and possibly other designers and contractors). Once occupied, the 'accountable person' or owner becomes the duty holder. New standards which set out the competencies required by the principal designer and principal contractor will be published by the British Standards Institution (BSI) by mid-2022.
Duty holders must demonstrate their approach to building safety to the Building Safety Regulator which will sit within the Health and Safety Executive (HSE) at the three gateways (planning, design, completion). The Building Safety Regulator is already working in 'shadow form' and is expected to get up to full speed within 12-to-18 months of the Building Safety Bill receiving Royal Assent.
More specific information on the golden thread setting out what information will be needed and how it must be stored will be provided in secondary legislation and guidance. These are currently being drafted and will be published for consultation, although no date for publication had been announced at the time of writing.
Why do we need the golden thread?
The information about a newly constructed building is handed over from contractor to owner via the building manual or operation and maintenance (O&M) manual.
The contents of the manual are usually set out in the original tender documents and can include a description of the design principles, details about the building's construction, as-built drawings and specifications, instructions on operation and maintenance, an asset register of plant and equipment, commissioning and testing results, warranties and certification and perhaps requirements for demolition9.
Additionally, the CDM (Construction Design and Management) Regulations require that the principal designer prepares a health and safety file10, which should be created at the pre-construction phase and updated through the construction phase. This could contain information such as hazards identified and how they were dealt with, structural principles, information relating to the use of equipment, the location of significant services.
Pre-digitalisation, the O&M manual would have been handed over as multiple lever arch files containing reams of paperwork. Today, although the documents may be delivered electronically, the accessibility of the information in them may not be much better than those fat files of paper.
In 2011, when the UK Government announced its intention to push the adoption of BIM in its Construction Strategy11, one of its core reasons for doing so was to improve asset management. The theory was that by tracking elements of a building from their design through into operation, it would be possible to deliver greater whole-life value. Building owners would have evidence of how products and equipment actually performed and would be able to make future purchasing decisions based on that. A decade on, this largely remains an aspiration.
Even before the Government's drive to BIM began, there were attempts by parts of the industry to improve the handover from construction to operation, of which data handover is an integral part. Back in 2009, BSRIA and the Usable Buildings Trust (UBT) launched the Soft Landings Framework. In 2016, the Government adopted and modified this to become Government Soft Landings. An important requirement of Government Soft Landings is the smooth transition of data and information from the project information model into the asset information model, as detailed in the UK BIM Framework12.
However, that transfer of information from the project information model, or BIM model into the asset information model or computer-aided facilities management (CAFM) system, is still proving challenging, thanks to barriers created by the software being used. A 2020 study13 by Dr Kay Rogage and Professor David Greenwood of Northumbria University tested over 100 building models and found that the way the models had been authored made it impossible for them to be transferred automatically into FM tools.
The researchers comment in their report: "In our research sample there were persistent difficulties with the accuracy of models and their logical organisation: and these appeared to be due to modellers' inexperience, lack of time, incentive or realization of what is required."
For the golden thread to become a reality, there is a huge need to standardise the way that models are created and labelled (see section 'How can building owners get ready?' to see how some are tackling this).
Golden thread at a glance
1. The golden thread will hold the information that those responsible for the building require to:
Show that the building was compliant with applicable building regulations during its construction and provide evidence of meeting the requirements of the new building control route throughout the design and construction and refurbishment of a building.
Identify, understand, manage and mitigate building safety risks in order to prevent or reduce the severity of the consequences of fire spread or structural
collapse throughout the life cycle of a building.
2. The information stored in the golden thread will be reviewed and managed so that the information retained, at all times, achieves these purposes.
3. The golden thread covers both the information and documents and the information management processes (or steps) used to support building safety.
4. The golden thread information should be stored as structured digital information. It will be stored, managed, maintained and retained in line with the golden thread principles. The government will specify digital standards which will provide guidance on how the principles can be met.
5. The golden thread information management approach will apply through design, construction, occupation, refurbishment and ongoing management of buildings. It supports the wider changes in the regime to promote a culture of building safety.
6. Building safety should be taken to include the fire and structural safety of a building and the safety of all the people in or in the vicinity of a building (including
emergency responders).
7. Many people will need to access the golden thread to update and share golden thread information throughout a building's lifecycle, including but not limited to building managers, architects, contractors and many others. Information from the golden thread will also need to be shared by the Accountable Person with other relevant people including residents and emergency responders.
Source: Building Regulations Advisory Committee: golden
thread report
How can building owners get ready?
Some high-rise residential building owners have already started work on their golden thread strategies. Since the Building Safety Bill will require that the relevant safety information is at hand for existing buildings as well as newly built ones, it makes sense for landlords to begin surveying and logging data now.
Social landlord WHG has created digital models of 17 highrise and five over-55s buildings, with residents able to access the digital versions of their buildings, according to an article in Inside Housing16. The local fire service will also have access to the app so that, in the case of a fire, they immediately have information such as the number of floors, building materials, hydrants and occupation. WHG is now making the app it developed available to other housing associations at cost.
For those landlords that are less digitally savvy, it is time to wise up. The Government is clear that golden thread information must be held digitally; landlords need to assess current information management systems and tools, and, where necessary, update and upgrade them.
Building owners are also building up the competency they need to be able to oversee both structural and fire safety, investing in training to create building safety managers – although some will choose to employ outside consultancies to take on this role. CIOB-approved courses17 lead to a Level 6 Diploma in Building Safety Management which is equivalent to a bachelor's degree, giving an indication of the depth and breadth of topics covered.
Landlords must also think about how they procure new build and refurbishment projects. BIM is less widely used in the residential sector than other sectors, but landlords would be well-advised to write the requirement for BIM into the contract. Tenders should also lay out how different databases and software packages are expected to talk to each other (see section 'How best to manage golden thread data?').
Standardisation of data is also important, as underlined by the findings of the Northumbria University researchers referenced above. The Housing Associations' Charitable Trust (HACT) has worked with industry partners to develop UK Housing Data Standards¹8. Launched in 2018, and now on version 3.4, the standards are available to download for free.
One of the big issues to be tackled is who owns the data. The CIOB and i3PT survey referenced earlier found that there was no consensus on who owns the data at each stage of an asset's life. Building owners may want to ensure that they own the data from day one which will have contractual and cultural impacts.
Building owners, just like designers and contractors, are advised to keep up to date with the developing policies, legislation and guidance.
How can contractors get ready?
The message to any designer or contractor is to act now. Clearly those companies working on buildings that fall within the scope of the Building Safety Bill need to move the quickest, but the requirement for an auditable digital information trail on every project is only around the corner.
Leading players may take the opportunity to offer the golden thread before it is mandated as a differentiator and a service to their customers.
One of the big issues to come out of the Hackitt review and the Building Safety Bill is the need to ensure the competence of those professionals working on higher-risk buildings. As mentioned above, new BSI standards will cover competence requirements.
On 14 October 2021, BSI opened a public consultation14 for PAS 8672: Built environment – Framework for competence of Individual Principal Contractors and Designated Individuals working under Organisational Principal Contractors – Specification. The new PAS – publicly available standard – will look at the competence of principal contractors across a raft of areas including building regulations compliance, managing building safety, identifying and managing building safety risks, managing the assembly of buildings and record keeping.
PAS 8671 Built Environment – Framework for competence of individual Principal Designers – Specification had not yet been put out for consultation at the time of writing. It would make sense for both contractors and designers to carry out a skills and competency audit of their teams to work out where the gaps are and to plan and organise training accordingly.
Equally important would be an audit of the processes and tools used to gather and store project-related information now; are these sufficiently robust for demonstrating to the Building Safety Regulator that all the building regulations have been met and all the risks assessed and addressed?
At a strategic level, companies could take this opportunity to address their broader approaches to information management. A study15 for the Centre for Digital Built Britain (CDBB) by KPMG and Atkins published in July 2021 makes the case for construction sector companies to invest in information management. Analysis of eleven case studies suggested that a £1 investment in information management could result in between £5.10 and £6.00 of direct labour productivity gains and between £6.90 and £7.40 on direct cost savings.
It is important for companies to keep abreast of all publications and information related to the golden thread, not least the expected secondary legislation and guidance that will be published for consultation. Larger companies are advised to give an individual responsibility for doing so and for disseminating the information to the right people.
How best to manage golden thread data?
The concept of the golden thread – data flowing through the different stages of a building's life, gathering more connected data as it goes – seems difficult to deliver given the current way information is held and used. Rather than flowing freely, data is very much constrained within discreet boxes.
Often the software or system provider does not want to make the information exportable because they have tools for many stages of the building lifecycle that they want to sell. Or the party creating – and hence probably owning – the data at that point may want to hang onto that data for commercial reasons.
There are currently a number of options for enabling information to flow which are outlined below. But, as stated earlier, clients will need to be very clear in setting out their requirements in this regard.
BIM and IFC
The idea that software systems should be able to talk to each other is not new. Back in 1994, Autodesk with 12 other companies created the Industry Alliance for Interoperability (IAI) which has since become BuildingSMART whose mission is to encourage wider use of openBIM: using open standards so that different software can all use the same data.
The IAI invented Industry Foundation Classes (IFC), a standardized schema – or data model – to allow data to pass between software packages. The first IFC was published in 1996, and has been regularly updated since. BuildingSMART is currently overhauling the IFC, which is set out in international standard ISO 16739.
Some public authorities around the world have mandated the use of IFC¹9. However, although IFC and openBIM seem like a good idea, there can be some practical challenges with their application.
An application programming interface (API) is bespoke software created to allow information to be transferred between one application and another. They may be developed to meet contractual specifications, but more often APIs are created because software companies choose to collaborate for mutual benefit – and to offer added value to their clients.
Unlike openBIM, APIs allow far more tailored and controlled access to data. APIs can be a useful tool in maintaining the strength of the golden thread as they allow automated information transfer between software, reducing the likelihood of errors.
Document management systems
One of the principles set down in the BRAC golden thread report is that golden thread information needs to be stored not only digitally but in a way that makes it easy to read, so that people can find, update or extract the information they need. One option could be a document management system which can read different types of digital records and can also keep a record of new versions and who created or modified them.
Cloud-based systems such as Asite provide a common data environment or central repository where all project information is stored. They also provide an audit trail of updates and changes to information. PAS 1192 and BS 1192 set out how to create a common data environment.
How 3D Repo can help manage golden thread information
Aside from the challenge of removing health and safety risks from construction sites and operational assets, there are other, interdependent hurdles that the construction industry is facing.
3D Repo already uses APIs to transfer data between itself and many other software applications such as Asite, Procore and Power BI. The APIs can also be used to extract data for project dashboards or reporting.
3D Repo was created with collaboration in mind, as an accessible way for multiple parties to access a 3D model through a web browser. One of its features is the Issue Tracker which allows users to pin an item or area that requires input or resolution, with the issue assigned to the relevant person and the actions and conversations related to it automatically recorded.
Another tool with the same collaborative and auditing power is SafetiBase. SafetiBase is widely used during the design and pre-construction phase to examine potential construction and operational health and safety issues and look at how risks can be removed or mitigated, perhaps by changing construction sequences or methods.
By including fire safety experts and fire services in early design discussions around the model, their feedback and the resulting decisions can also be recorded.
This means that on projects where 3D Repo has been utilised, the resulting database acts as a golden thread of information for design decisions and risk mitigations. The audit trail records the discussion and gives full traceability as to how decisions were made, who made them and when were the actions taken. More importantly, by utilising the collaborative power of 3D Repo, the project will have allowed project teams to avoid costly mistakes and mitigate risks
which could have harmed the team and the eventual users of the asset.
Getting ready for the golden thread
Ensuring that those who have responsibility for managing buildings have all the information they need to keep residents and users of that building safe should be a moral imperative – and not just a legislative one.
Creating a strong digital golden thread will require robust information management systems and the ability for data to flow between the tools used during different phases of a project.
Organisations must assess their systems now, work out what changes are needed and create a roadmap of how to get there. Clients must also reconsider contractual arrangements that allow more open access to data.
New ways of working will inevitably require new skill sets and competencies. Clients, contractors and designers may need to upskill or recruit people with different skills, in building safety perspective and in data management.
With the Building Safety Bill expected to come into force as early as 2023, the time to act is now. Although the golden thread will initially only apply to high-rise residential buildings, care homes and hospitals, expect to see it appearing in tenders for projects in other sectors soon.
Getting started with digital health & safety
The industry needs a step change. Technology offers the opportunity for that change.
http://www.thenbs.com/digital-construction-report-2021/_download/NBS_digital_construction_report.pdf
https://www.goldenthread.co.uk/Golden-Thread-Review.pdf
https://www.gov.uk/government/publications/independent-review-of-building-regulations-and-fire-safety-interim-report
https://www.gov.uk/government/publications/independent-review-of-building-regulations-and-fire-safety-final-report
https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/941536/The_Construction_Playbook.pdf
https://www.ukbimframework.org/
https://www.gov.uk/government/publications/building-regulations-advisory-committee-golden-thread-report/buildingregulations-advisory-committee-golden-thread-report#golden-thread-definition
https://www.gov.uk/government/publications/building-safety-bill-factsheets/golden-thread-factsheet
https://www.designingbuildings.co.uk/wiki/Building_owner%27s_manual_-_O_and_M_manual
https://www.designingbuildings.co.uk/wiki/Health_and_safety_file
https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/61152/Government-Construction-Strategy_0.pdf
https://ukbimframework.org/wp-content/uploads/2019/11/GSL_Report_PrintVersion.pdf
https://www.researchgate.net/publication/346208538_Data_transfer_between_digital_models_of_built_assets_and_their_operation_maintenance_systems
https://www.bsigroup.com/en-GB/about-bsi/media-centre/press-releases/2021-press-releases/october/publicconsultation-open-for-pas-8672/
https://www.cdbb.cam.ac.uk/files/cdbb_econ_value_of_im_report.pdf
https://www.insidehousing.co.uk/insight/insight/what-steps-should-landlords-be-taking-on-the-golden-thread-70644
https://housinglms.com/building-safety-manager/ and https://www.ciob.org/learning/finding-courses/ciob-level-6-diploma-building-safety-management
https://www.hact.org.uk/DataStandard
https://en.wikipedia.org/wiki/Industry_Foundation_Classes

redpajama_set_name: RedPajamaCommonCrawl


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SpActrum Studio is a cross-discipline design and art studio founded in 2011. We start from our own observation and contemplation, and undertake research through art and design practice, and build up an extended critical discussion platform through publication. We work on architecture, space, objects, images, culture reading and many other areas. Our thinking territories are expanded from our introspection and interests to the surroundings to more comprehensive fields and subjects, to explore alternative research methods and deepen our critical practice.


text:
Spider-Man Heat Vision Breakdown
Weekend Box Office: 'Halloween' Eyes Another $80M October Record
October 19, 2018 7:24am by Pamela McClintock
'Halloween' | Courtesy of TIFF
Forty years later, Jamie Lee Curtis reprises her role as the iconic Laurie Strode, who once again faces off with Michael Myers.
Blumhouse and Universal's Halloween did terrifying at the Friday box office, earning $33.3 million from 3,928 theaters for a weekend gross of $80.3 million, tying with Venom's launch earlier this month for an October best.
To boot, the pic — a direct sequel to the 1978 classic slasher hit — is scoring the second-best opening of all time for an R-rated horror pic behind New Line's blockbuster It, which opened to $123.4 million in September 2017, not adjusted for inflation. In addition to stellar reviews, Halloween nabbed a B+ CinemaScore, a good grade for the genre.
This Week In Heat Vision breakdown
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Directed by David Gordon Green, Halloween sees the return of Jamie Lee Curtis as the iconic character Laurie Strode, who once again faces off with Michael Myers, the masked figure who has haunted her since she narrowly escaped his killing spree on Halloween night in 1978. (Nick Castle reprises his role as Myers.) After Blumhouse landed rights to the Halloween franchise, Jason Blum tapped horror icon John Carpenter, who directed the 1978 film, to serve as creative consultant.
October box office revenue is running at record levels thanks to Sony's Venom and Warner Bros.' A Star Is Born, both of are still impressing in their third weekends.
A Star Is Born is tipped to narrowly beat Venom for the weekend with $19 million, putting its domestic total at around $126 million through Sunday. Venom looks to score another $18 million-plus for a domestic haul north of $171 million by the time the weekend wraps.
The forecast for First Man in its sophomore outing looks muted. Damien Chazelle's astronaut drama is on course to gross $8.8 million, enough for a fifth-place finish behind holdover Goosebumps 2: Haunted Halloween.
Universal and Blumhouse's Halloween isn't the only new nationwide release this weekend. (Miramax is a partner on the film).
With awards season in full swing, Fox 2000 is expanding its YA police-shooting drama The Hate U Give into roughly 2,300 theaters. The film — earning a coveted A+ CinemaScore — could is on course to gross a strong $8.5 million to place No. 6.
New entries at the specialty box office include Can You Ever Forgive Me? starring Melissa McCarthy, IFC's Wildlife, Bleecker Street's What They Had and A24's Mid90s.
Oct. 19, 12:30 p.m. Updated with revised weekend estimates.
Oct. 20, 7:30 a.m. Updated with revised weekend estimates.
HEAT VISION LATEST NEWS
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July 19, 2019 12:01pm PT
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As an industry analyst, I've been waiting to write this post for a few years, it's fascinating to see the Cambrian Explosion (a prehistoric era where millions of species rapidly emerged on the earth) now turn into consolidated suites, as the ever fragmented Social Business Stack (we found 18 classes of software and service) unmanageable for brands who seek less complexity. Finally, we're starting to see the combination via partnership, as well as consolidation of platforms emerge.
In summary, the state of Social Software Suite (SSS) is immature. The the M&A is just happening across the industry and the integration stories have few proof points or customer case examples, we're in a stage of infancy for social suites. While we've seen many social media proof points, hearing how social integrates into email, advertising, crm, support software, BI, CMS, and beyond is in it's early stages. Without a doubt, we're entering another era of the social space.
Integration occurs after a Cambrian Explosion. When I show brands the social business stack of vendors, they often sigh, get frustrated, as they know they're the ones that must integrate all the pieces together. They seek a common set of vendors to emerge that they don't have to constantly coach on R&D and integration partners, and are waiting for maturity in products and consolidation so they have to analyze less vendors. Secondly, as social integrates with all other incumbent software, the need for suites to emerge are only underscored.
High Valuations Forces Biz Dev and M&A. The industry is feeling a domino effect. As a few acquisitions start happening, large software enterprise players know they need to make their bet on the table to get into this game, after initial innovation was done by startup vendors. With IBM, Adobe, Lithium, Salesforce making some of the early plays this has set off an arms race for other vendors to develop their integrated suite.
Facebooks IPO "Debacle" makes M&A more attractive. With Facebook's IPO not going as well as financial analysts had hoped with initial valuations, the hopes of these startups to go IPO and succeed like 10 years ago have now shifted to M&A deals, where the exit is combining with a large player. The domino effect causes all investors, boards and executive teams to make their deals and moves before potential windows from suitors dries up. It's dating season, and everyone wants to mate.
Suites are Good for Brands Who Tire of Complexity: Brands are tired of dealing with hundreds of vendors, and having data and logins and systems spread across the space. They seek consolidation from their providers, as doing it themselves in a rapidly changing environment is complex, expensive, and frustrating. Expect brands to line up at the C level to embrace vendors that provide high level dashboards that provide real time reporting on these tools, and enable multiple business units to manage social use cases across the company.
The Future is Integration of Paid, Owned, and Earned: Altimeter's current research on the integration of Paid, Owned, and Earned (POE) has already found early indicators that brands, and their agency partners are seeking tools that interwork together, and as a result a new team within a corporation will emerge to lead this charge, agency partners will restructure and new software will emerge to make this come to life.
If you're like me (who's full time job is to track this) this is a confusing space to track, as a result, I'll keep this list updated for a few quarters, till it doesn't make sense to manage this or it's time for me to do a formal vendor rating and ranking. Disclosure: Your trust is important to us, as a result, we want to disclose many of these vendors are clients of Altimeter Group. Vendors are listed in alpha order.
Adobe Ads, Targeting, Analytics, Social Media Management System, Social CMS Adobe was the first to launch a nearly complete suite that spans the entire digital marketing push at their Summit conference. Although mainly marketing, they must bolster into customer support positioning beyond CQ5 this is a strong contender that already has an enterprise marketing footprint via creatives and now with Omniture.
Bazaarvoice Ads (Media), Social integration in .com, analytics Bazaarvoice recently acquired top competitor PowerReviews giving them a lock hold over ratings and reviews across the industry. Recently, the announced a media product that extends social ads beyond .com and even beyond FB and Twitter ads. They must expand to engagement software to cover the full span.
Google Search marketing suite, social network, applications, social media management system (Wildfire) and analytics Google's strengths in search marketing has started to extend to Google+, although adoption numbers are a fraction of other social networks. Expect that Google Analytics combined with collecting of data from Google+ will impact search results in search engine results pages. Now with Wildfire, they can extend into the Facebook platform, as well as deploy Google ads in multiple locations, as well as tie to Google Analytics.
IBM Analytics, Brand Monitoring, Targeting, CRM A strong existing player that acquired Coremetrics, they have a strong background in analytics and intelligence, but need to develop an engagement solution that allows brands to engage in social while aggregating data back to their systems.
Lithium Communities, Engagement software, brand monitoring Traditionally a community vendor on support use case, they've acquired Scout Labs for brand listening and recently announced a white label engagement tool. They must quickly move into the marketing aspect beyond support and launch an advertising platform that converts earned content to paid.
Oracle Social Media Management System (Vitrue), Social Analytics (Collective Intellect) CRM and now Involver New entrant, they acquired Vitrue for an assumed $300m showing the promise of social data into existing CRM systems a reality. The roll-out isn't quite clear for roadmap, I look forward to hearing more. (edit: now that they've acquired Collective Intellect, the pieces fit together: listening, engagement, analytics.
Salesforce Brand Monitoring, CRM, Data.com, lightweight community products Traditionally strong in sales and support use cases, Salesforce (edit: has purchased) BuddyMedia (who purchased ad platform Brighter Option) that would quickly extend them into a new arena, this fast mover is disruptive and is to watch.
Whoever Comes Next TBD: TBD: I'll update this as vendors emerge.


text:
NCCE partners Graphic to run clean Accra campaign
BY: Nana Konadu Agyeman
Mr Victor Avadu, Resource Person, NCCE, Accra Metro, interacting with Mrs Mavis Kitcher, acting Director of Newspapers, GCGL during the visit.
The Accra Metro Office of the National Commission for Civic Education (NCCE) is to partner the Graphic Communications Group Limited (GCCL) to embark on a clean-up campaign in Accra.
The GCGL will offer free publicity on the campaign, christened "Keep Accra Clean," to create public awareness and garner goodwill to sustain the initiative.
The campaign, scheduled to start on November 2, 2018, will initially focus on mobilising stakeholders, traders, market women, schoolchildren and other members of the general public, to clean areas at Kaneshie, Agbogbloshie and the Kwame Nkrumah Interchange.
In pursuit of the partnership, some officials of the Accra Metro office of the NCCE, led by its Resource Person, Mr Ben Victor Avadu, and the acting Director of the NCCE Accra District, Ms Constance Effah, paid a courtesy call on the acting Director of Newspapers of the GCGL, Mrs Mavis Kitcher, at the head office of the company last Friday.
Shared responsibility
Giving details of the initiative, Mr Avadu said the clean-up exercise would be carried out fortnightly.
He said as part of its civic mandate, the commission needed to take education on sanitation seriously, since the sanitation situation in the country, particularly in the national capital, Accra, was not the best.
He said it was for such reason that the President set up the Ministry of Sanitation and Water Resources and called on all members of the public to help make the vision of clean cities and towns in the country a reality.
Mr Avadu said sanitation in most parts of the country left much to be desired, the reason for which the commission had decided to engage in a pre-Christmas sanitation education programme in the last quarter of 2018, saying that, "we cannot celebrate Christmas in a filthy environment."
Lack of funding
He said because the lack of funding and logistics was the major challenge to implementing the exercise, the NCCE had decided to also partner the Zoomlion Ghana, the Accra Metropolitan Assembly and other institutions.
Free publicity
Responding, Mrs Kitcher commended the NCCE for seeking a partnership with the GCGL to help achieve the goal of ridding Accra of filth.
She expressed concern about the inclination of some people to neglect their responsibility to keep their surroundings clean.
"People complain that there are no dustbins in the communities but even where they are, these collection bins pile up and spill over and nobody picks them.
"What we need to do as citizens is to play our part, and the metropolitan assemblies have to ensure that when these dustbins are full, they are picked and emptied to discourage people from dropping garbage on the ground," she said.
Mrs Kitcher said the media could play a major role to help educate the public and sustain the campaign, adding that, "for our part, we are willing to support you to sustain the campaign since we do not want diseases in our communities.
"As a state organisation, we want to support other state institutions that are working to achieve results; so do not stop midway," she urged the NCCE, and asked the commission to set targets that it could achieve.


Here is a list that cross-references which type of magic fruit you get from any specific crop when you use the "Plant Breeding" action. Plant Breeding is an action that you can take when you are breeding new seeds from crops within your own farming fence. Note that this list only applies when using the "Plant Breeding" action. Any other gathering of crops gives a random type of magic fruit.
If you need a single specific fruit, like Fruit of Magic Power, you can use this method to your advantage. Just plant the specific crop from the list below which corresponds to the fruit you need and when ready use the "Plant Breeding" action on all of them. To get Fruit of Magic Power, you would need to plant emperor mushrooms or hump mushrooms.
the Sun Corn, Paprika, Tomato, Wheat.
Missing crops: Acacia, Flax, Penestraria, Dalvenia, Nolina.
Missing mushrooms: Purple, Tiger, Pie, Ancient, Bluffer, Ghost, Bouquet, Amanita, Leccium.


text:
Winning Him Back
By confused33
September 17, 2006 in Ex-boyfriend/girlfriend Relationships
Ive posted on here before but never really to ask this kind of advice.... I really need to know if there is anything I can do to try and win my Ex back. We dated for almost 3 years when we were younger. Then we grew up and remained friends for a while until I met someone else and that person made me stop being friends with my Ex. I ended up getting engaged and then ending my engagement but now I am single and enjoying life. Two months ago when I was having issues I decided to write my ex and he was super excited to hear from me but only because he was having issues with his girlfriend. But now that he is not having issues with his girlfriend he wants me to kinda sit on the back burner. I really care about him and I want advice on how to win him back... Is there anything i can do?
annie24
well, if his problems with his gf are solved, I think you are better off moving on. meet some new guys. if he is single again in the future, he knows where he can find you.
Relationship Coach
Is there anything you can do? No, he has to want to come back. Right now he is involved with someone else, respect that and stay away. Get on with your life and if it is meant to be, it will happen on it's own.
I really think its because I hurt him now he wants to hurt me. But he wrote me two letters after the initial contact telling me that he cant stop thinking about me. I believe him when he says this, because I think he is just scared to break it off with the girl that he dating now. I havent heard the best of things about her.
yeah, but he's still with her isn't he? and that's the only fact that counts.....
So there isnt anything I can do to try and win him back. Hes said that he was only with this girl because he lost hope that I would ever come back.
He asked if I could come see him while she wasnt around so we can see if there is anything that will spark between us...
hm.... i guess if I were in your shoes.... (and this is just me), I might just say to him, "you know, I'd really like to try again with you, but only if you are single. if you want to be with me, let's try again, break up with your gf. if you don't want to be with me, then i'm going to move on."
That is a very good straight forward thing to say.. Thank you
Is my new friend a flirt or is he interested?
By courtney_2001, November 26, 2022
HeartGoesOn
She told me to move on. 1 2
By Zenon1267, September 19, 2022
jul-els
Should this be cause for concern in my relationship? 1 2
By sysnoot, September 11, 2022
ImpulseVindicator
The Love of My Bf's Life Moves Back In
By FortuneNavi, August 20, 2022
disrespect
questionable?
ignoring me
disregarded
Confused by Ex's behaviour
By Eahlswith, August 2, 2022
insecurities
hoovering


text:
Acxiom Expands Partnership with DataXu
First-of-its-kind partnership bridges the gap between television and digital audiences
LITTLE ROCK, Ark., Jan. 31, 2017 /PRNewswire/ -- Acxiom® (Nasdaq: ACXM), the data foundation for the world's best marketers, today announced it has expanded its partnership with DataXu, a leading provider of programmatic marketing software, to allow DataXu to license its third-party data for advanced TV and analytics solutions. The first-of-its-kind partnership will allow advertisers and agencies to engage their own first-party audiences across all addressable channels, including TV, and drive more effective data-driven marketing across all screens.
Prior to this partnership, advertisers lacked the ability to engage consumers in a unified way across all the devices and media channels they use during the buying lifecycle. Now Acxiom and DataXu are partnering to connect the dots between the digital and TV worlds. This enables marketers to achieve greater message consistency and relevance to consumers, as well as overcome the challenges associated with today's increasingly fragmented media landscape. For their most important audiences, advertisers can now bridge the gap between desktop, mobile and TV and control reach and frequency across these channels. Additionally, the expanded Acxiom-DataXu partnership gives advertisers and agencies the ability to gain deeper customer insights into the previously disconnected digital and TV worlds.
"We are pleased to expand our partnership with DataXu to arm marketers with the insights they need to scale media investments across more channels," said Anne Doherty, Senior Vice President of Sales, Acxiom's Audience Solutions division. "Being able to provide such valuable insights underscores the importance of our partner network and validates Acxiom's identity resolution technology – AbiliTec® – as the most powerful in the industry. We look forward to continuing to help platforms, agencies and advertisers engage consumers in a more meaningful way and gain more pertinent insights."
"DataXu's partnership with Acxiom enhances our digital and TV marketing solutions for advertisers and agencies, enabling them to craft more personalized and relevant customer experiences. DataXu's expertise, suite of analytics, cross-device and programmatic marketing technologies, coupled with Acxiom's rich third-party data, is an extremely powerful combination," said Tore Tellefsen, Vice President of TV Solutions at DataXu. "With customers in control of their own cross-device buying journey, it's important for marketers to also be able to break down internal silos between digital and TV channels."
About DataXu
DataXu's mission is to make marketing better using data science. The world's top brands and agencies use DataXu to better understand and engage customers across all devices and media formats. Its solution provides marketers with unparalleled Media Activation, Marketing Analytics and Data Management capabilities. With sixteen offices in eleven countries, DataXu's full-stack solution is powering the marketing transformation of the world's most valuable brands.
About Acxiom
Acxiom provides the data foundation for the world's best marketers. We enable people-based marketing everywhere through a simple, open approach to connecting systems and data that drives seamless customer experiences and higher ROI. A leader in identity and the ethical use of data for more than 45 years, Acxiom helps thousands of clients and partners around the globe work together to create a world where all marketing is relevant. For more information about Acxiom, visit Acxiom.com.
Sherry Hamilton, 501-252-6029
GACXM
Katie Gabriello, 781-354-2380
DataXu PR Manager
SOURCE Acxiom
http://www.acxiom.com


text:
#ifndef _ASM_ARCH_BD82X6X_H
#define _ASM_ARCH_BD82X6X_H

void bd82x6x_sata_init(pci_dev_t dev, const void *blob, int node);
void bd82x6x_sata_enable(pci_dev_t dev, const void *blob, int node);
void bd82x6x_pci_init(pci_dev_t dev);
void bd82x6x_usb_ehci_init(pci_dev_t dev);
void bd82x6x_usb_xhci_init(pci_dev_t dev);
int gma_func0_init(pci_dev_t dev, struct pci_controller *hose,
		   const void *blob, int node);
int bd82x6x_init(void);

/**
 * struct x86_cpu_priv - Information about a single CPU
 *
 * @apic_id: Advanced Programmable Interrupt Controller Identifier, which is
 * just a number representing the CPU core
 *
 * TODO: Move this to driver model once lifecycle is understood
 */
struct x86_cpu_priv {
	int apic_id;
	int start_err;
};

int model_206ax_init(struct x86_cpu_priv *cpu);

#endif

redpajama_set_name: RedPajamaGithub


So you've decided to list your home this winter. Perhaps you've had a job change, need to relocate out of the area, or have financial or family reasons for moving. No matter what is driving the move, you may be concerned about selling at this time of year. But just because you missed the boat on the spring selling season doesn't mean you can't get your home sold quickly, and for a profit. A few tips can help get it moving.
If you can take photos before the trees become barren and the grass goes dormant, do so! The last thing you want is for your home to look blah and depressing in photos. If you can capture a snowy day (with perfectly scraped walkways, of course), that works, too. It never hurts to have your home looking like a winter wonderland.
"Deck the halls, but don't go overboard," said HGTV. "Homes often look their best during the holidays, but sellers should be careful not to overdo it on the decor. Adornments that are too large or too many can crowd your home and distract buyers. Also, avoid offending buyers by opting for general fall and winter decorations rather than items with religious themes."
Just because it's winter doesn't mean you can let things slide out front. Potential buyers won't give you a pass on chipping paint, a fence that needs repair, or a front door that's seen better days just because it's frigid outside.
Shoveling the walk from the street to your home is necessary to make it reachable, make it inviting, and also make it safe. The last thing you want is a slip and fall that could result in an injury, and a lawsuit. "Continually shovel a path through the snow, especially if snowflakes are still falling," said the balance. "Footprints on freshly fallen snow will turn to ice if the temperature is low enough, so scrape the walk. Sprinkle a layer of sand over the sidewalk and steps to ensure your buyers' stable footing. Remember to open a path from the street to the sidewalk so visitors aren't forced to crawl over snowdrifts."
Perhaps you never use a mat for indoors or yours is grubby or tattered from 10 straight years of winter wear. This one super easy move may not be noticed by visitors - but it sure will if it's missing or not in good shape. Little things like a $10 mat can give buyers the impression that your whole house is well cared for, or just the opposite.
If you live in a climate where there is likely to be snow or rain, there are a few more steps you'll probably have to take in order to keep your house looking great inside. How does your coat closet look? If it's stuffed with jackets, scarves, boots, and gloves, relocating some to make room for potential buyers to put their stuff away while touring your home is a good idea - plus, a tidy coat closet gives the impression that there is plenty of storage space in the home. It goes without saying that winter wear and shoes that tend to stack up in the entry should be banished while your house is on the market.
Imagine you live in a climate that stays relatively temperate year-round, and then you have a cold spell. You turn on the heater for the first time the night before your first showing, and…nothing. Same for the fireplace in the living room. Your freezing cold house is probably not going to make a great impression on buyers. As soon as you decide you're going to sell your home, go through it room by room, checking all major appliances and home functions and looking for little things that may escape notice on an everyday basis - cracked light switches, chipped baseboards, light bulbs that need to be replaced - so your home is perfect for showings.
Shorter days with earlier sunsets limit the amount of natural light in your home. Turning on all the lights before showings is more important than ever. Think about the exterior when it comes to lights, too. If you only have a porch light, you might want to consider adding some landscaping lighting, which will help accentuate your outdoor space.
Will you be able to command top dollar for your home and get the same price you would have had you listed in spring or summer? That depends on so many things, including your neighborhood, the available inventory, the condition of the home, and, of course, your listing price. A trusted real estate agent will take all mitigating factors into consideration and use comparables in your area to develop a pricing strategy.
When it comes to offers, remember this tidbit from Realtor.com: "Just because your home's on the market during the slow, chilly months doesn't mean you have to accept a lowball offer. If you make your home attractive in all the right ways, qualified buyers will come."


Recognizing the critical nature of NUT, the NUT Quality Assurance (NQA) effort has been established to improve NUT where necessary, and to maintain software quality as high as it should be.
NQA is present in many aspects and areas of NUT.
The documentation toolchain uses AsciiDoc to output both HTML pages and manual pages (troff). This single point of control fills many gaps, suppresses many redundancies, and optimizes documentation management in general.
The NUT website and HTML documentation are tested for W3C XHTML 1.1 and CSS compliance. This can be counter verified by clicking the W3C XHTML 1.1 and CSS icons, at the bottom of each page.
Documentation source files are spell checked, using Aspell, both interactively (using make spellcheck-interactive) and automatically in Buildbot (using make spellcheck).
A NUT dictionary is also available (docs/nut.dict), providing a glossary of terms related to power devices and management.
a Revision Control System (Git) to track development and ease regression fixes.
Buildbot to automate the compile/test cycle. Any build failure is caught early, and fixed quickly.
piuparts automates the installation, upgrade and removal testing processes.
a runtime testing suite, which automates the inter-layer communication testing (driver - upsd - upsmon / clients), that is part of Ubuntu. The NUT testing script is available in the Ubuntu QA Regression Testing suite. It installs NUT, configures it with the dummy-ups driver, changes a few data and checks that these are well propagated with upsc.
Black Duck Open Hub (formerly Ohloh.net) provides metrics on NUT source code base and activity.
NUT provides many security features to ensure a maximum runtime security level.
Packages use several Hardening methods to protect NUT binaries.


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Farxiga - SGLT2 Inhibitors Mass Tort Lawsuit Lawyers
More and more Americans are being diagnosed with diabetes. According to the Centers for Disease Control and Prevention (CDC), approximately ten percent of the population – over 29 million individuals – have been diagnosed with diabetes, and this number is expected to increase in the future. As the number of diabetics in America increases, so too are the treatment options available to help diabetics manage their condition.
In the past, those diagnosed with diabetes may have only had insulin-based treatments available to help them manage their blood sugar levels. Now, however, there have been a number of other drugs that have been developed and marketed to help diabetics in managing their condition.
Not all of these drugs are safe, however.
Dangers of Certain Drugs for Diabetics
Drugs such as Invokana, Farxiga, Xigduo, Invokamet, Jardiance, and other similar drugs have been marketed to Type II diabetics as a new type of diabetes medicine. (These medications are not to be prescribed for individuals who have been diagnosed with Type I diabetes.) These drugs are classified as sodium-glucose co-transporter-2 (SGLT2) inhibitors. SGLT2 helps the body reabsorb glucose through the kidneys. An SGLT2 blocks this reabsorption process and thereby increases the amount of glucose secreted from the body. This, in turn, lowers the amount of glucose in the bloodstream.
SGLT2 inhibitors may cause serious, even life-threatening, side effects such as:
Diabetic ketoacidosis: This life-threatening condition can develop if the body experiences a shortage of insulin with which the body normally processes glucose. Symptoms of diabetic ketoacidosis include vomiting, dehydration, and confusion. In some cases, the diabetic may fall into a coma. With timely medical intervention, diabetic ketoacidosis can be managed and need not be fatal.
Acute kidney injury or kidney failure: The "filters" of the kidneys (called the glomeruli) can become damaged because of diabetes. High blood sugar levels can cause these "filters" to allow higher-than-normal amounts of the proteins like albumin. If left untreated, this can cause scarring of the kidney tissue, which reduces the ability of the kidneys to function as intended.
Heart attacks: Heart attacks (also known as myocardial infarctions) occur when the supply of oxygen-rich to the blood is slowed or blocked. Without oxygen, muscle cells in the heart begin to quickly die. This causes permanent damage to the heart and can lead to death.
Other complications have been linked to SGLT2 inhibitors, including strokes, urinary tract infections, deep vein thrombosis, and the necessity of removing toes, feet, and/or legs because of damage to the nerve and tissue brought about by abnormal blood sugar levels.
Response of the Food and Drug Administration (FDA)
The Food and Drug Administration (FDA) has cautioned patients about the link between SGLT2 inhibitors and diabetic ketoacidosis. However, in more recent times the FDA has also begun highlighting the potential risks of acute kidney injury and serious urinary tract infections. Some of these conditions are brought about because a person whose diabetes is not controlled well will have too much acid in his or her blood (a byproduct of the body breaking down fat because it is unable to use glucose because of a lack of insulin).
The Role of Drug Manufacturers of Diabetic Medications
Although the FDA controls whether a new medication is able to be marketed and released for sale as a medication, it falls upon the manufacturer of a diabetic drug to conduct sufficient studies and trials before allowing patients to use the drug. The manufacturer is responsible for producing a drug that is reasonably safe for use. The manufacturer must further undertake steps to discover potential side effects (like diabetic ketoacidosis and kidney failure) that normal use of its drug might cause. Where such side effects are possible – even if they are not probable – the manufacturer must provide potential consumers with adequate warnings about these potential side effects.
Have You Experienced Complications from Your Diabetes Prescription Drug?
If you are a diabetic who was prescribed Farxiga or another SGLT2 inhibitor drug and suffered a serious injury or required hospitalization after a heart attack or stroke, you may be entitled to compensation from the manufacturer of that drug. Your ability to obtain compensation will depend in part on showing that the drug manufacturer either knew or should have known that its drug was unreasonably dangerous and/or that the drug manufacturer provided you with inadequate warnings about the drug's side effects. It must also be shown that your diabetes drug caused or contributed to your injury or condition.
When you need experienced and skilled legal representation following a diabetic drug injury, look no further than the knowledgeable law firm of Stern Law, PLLC. We have helped numerous clients recover compensation for medical bills, lost wages, and other losses following a drug-related injury. Learn what our firm can do for you by calling Stern Law, PLLC at (844) 808-7529.
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Bipartisan Group Backs Extension of Carbon Tax Credit
UWUA National July 1, 2017
The bill has the support of both fossil fuel companies and environmental groups. At present, the 45Q provision awards $10 per metric ton of stored industrial CO₂ used in enhanced oil recovery (EOR) projects, and $20 per metric ton for CO₂ stored in underground reservoirs. The new legislation calls for an increase to $35 and $50 per metric ton, respectively.
"I think everyone understands that we need to develop and expand this technology," said Sen. Heidi Heitkamp (D-N.D.), one of the sponsors of the bill, which supports carbon capture utilization and storage (CCUS). Heitkamp and other sponsors of the legislation spoke July 12 at a news conference on Capitol Hill.
"This is one of the rare, bipartisan carbon bills that we believe presents the sweet spot in America for getting the job done," said Heitkamp. "We come with different motivations but with the same vision. We want to provide certainty for our energy community and our environmental community."
The FUTURE Act would extend the 45Q tax credit and incentivize the development of carbon capture technologies, while also reducing emissions. FUTURE stands for Furthering carbon capture, Utilization, Technology, Underground storage, and Reduced Emissions.
Power Mag
ortor vehicula.
UWUA National Pushing to Keep Nuclear Plants Open
Far more is at stake than simply whether a plant such as Perry Nuclear will or will not close. The fate of an entire local economy hangs in the balance of such a decision. Allowing the economics of the moment to push such a plant to closure, ignores both the future of energy economics and the future of an entire community


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Flower Mound-Lewisville-Dallas
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Tickets are available now!
VIP Member Donors receive VIP reserved seating.
Are you a VIP? Annual Memberships start at $25. Click 'Support.'
Check out what's planned for 2020...
4th Annual Play Readers Club
Returns in 2020!
Dates JANUARY 30, FEBRUARY 27, AND MARCH 26, 2020 at the MCL Grand, 100 North Charles Street in Lewisville
Our Productions is happy to announce the continuation of the Play Readers Club. This club will meld both arts patrons and professionals together to explore both new (and classic ) scripts in a "Book Club" style approach. Join us for a new script each month, and take a reader's role…or just listen, as we read a work together and then discuss it, book club style. Donations welcome. Refreshments served. Suggested age 17 and up.
The Play Readers Club will meet at the MCL Grand, 100 North Charles Street, Lewisville, Thursdays at 7:30 p.m. Hosted by Stephanie Riggs, Educational Director of Our Productions Theatre Co. along with special surprise guest co-hosts. No tickets are needed for the Play Readers Club event, which will be FREE with donations accepted at the door. We hope to see you there at this fun, informal, educational community event.
The 2020 Play Readers Club is sponsored in part by The Town of Flower Mound and The City of Lewisville.
For more information or to let us know you are coming visit our Facebook Event:
Script submissions for 2020 is closed. Submissions for 2021 will be accepted for consideration from September 15 - October 31, 2021! Email PDF scripts to
info@ourproductions.org
with your name and the title of your play in the subject line, and include a short biography of yourself in the body of the email. Scripts should be submitted to us no later than October 31, 2020. Any length is fine. The three slots in January/February/March 2021 will be selected by our Board of Directors and Play Reading Committee.
Playwrightes pictured L to R - Lindsay Hayward, Ken Orman, Mikey Abrams
2020 Selections:
Thursday, January 30, 2020 - 7:30 p.m.
PETRICHOR by Lindsay Hayward
A ghost story tucked between the last century's world wars, Petrichor weaves together pairs of sisters, friends, lovers,
and nationalities in order to examine the past's true reality. Set in Pietermaritzburg, South Africa in 1938; the Graffe sisters return home from school to a new home, as well as some unexpected visitors. As darkness falls, the past and present collide while all must confront the spectral of family secrets. Petrichor is more than a straight fable. It's themes of duality, family lore, and social injustice cumulate into a conclusion that proves what lurks in the dark is often far too human.
Thursday, February 27, 2020 - 7:30 p.m.
RETIRED RESTLESS AND WRUNG OUT by Ken Orman
It's December 23rd. Dan and Denise's 50th wedding anniversary party is just hours away, but snow is falling... hard, threatening Denise's dream of having her three kids together for the first time in 20 years.
Thursday, March 26 2020 - 7:30 p.m.
THE JOY OF PUBLIK SKOOL by Mikey Abrams
After fifteen frustrating years in an inner city high school, a gay, Jewish drama teacher swears this year will be his last. His dream: to be a full-time actor. School's out for Mista – or is it? In this tart, too-honest one-man comedy, writer-performer Mikey Abrams doesn't filter reality. Just makes it funnier.
The classic musical GODSPELL book by John Michael Tebelak with Music and Lyrics by Stephen Schwartz will be presented by special arrangement with Music Theatre International and Actors' Equity Association by Our Productions Theatre Co. in conjunction with The Young Artist Training Program.
Performances will be held April 24-25, 2020 at the MCL Grand, 100 North Charles Street in Lewisville. Tickets on sale soon.
The production is directed by Stephanie Riggs with music direction by Mark Mullino. Choreography will be by Alex Altshuler. Sponsored in part by The City of Lewisville and The Town of Flower Mound.
Godspell was the first major musical theatre offering from three-time Grammy and Academy Award winner, Stephen Schwartz (Wicked, Pippin, Children of Eden); and it took the world by storm. Led by the international hit, "Day by Day," Godspell features a parade of beloved songs, including "Prepare Ye the Way of the Lord," "Learn Your Lessons Well," "All for the Best," "All Good Gifts," "Turn Back, O Man" and "By My Side." A small group of people help Jesus Christ tell different parables by using a wide variety of games, storytelling techniques and a hefty dose of comic timing. An eclectic blend of songs, ranging in style from pop to vaudeville, is employed as the story of Jesus' life dances across the stage. This special performance will explore the story through the eyes of the youth in an age of cyber bullying, social pressures, and their own individual communities. Dissolving hauntingly into the Last Supper and the Crucifixion, Jesus' messages of kindness, tolerance and love come vibrantly to life.
This production is suitable for all audiences. Tickets are $25 general admission, $20 for seniors, and $15 for students, children and industry members. Tickets are non-refundable, and exchangeable through email ticket link up to 24 hours prior to performance time. VIP reserved seating is for Donor Members by level. Groups of 10 or more receive a 10% discount.
To Be Announced...a NEW play will make it's debut! Part of Our Productions New Works Initiative. Watch for an announcement in early spring.
Mark your calendars now! The productions will be performed at the MCL Grand September 18-20, 2020.
This production is rated R for language and subject matter and suggested for ages 17 and up. Tickets will be on-sale soon. Sponsored in part by The Town of Flower Mound.
Tickets are $25 general admission, $20 for seniors, and $15 for students, children and industry members. Tickets are non-refundable, and exchangeable through email ticket link up to 24 hours prior to performance time. VIP reserved seating is for Donor Members by level. Groups of 10 or more receive a 10% discount.
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