text:
The WindAction Group (www.windAction.org)
Facts, analysis, exposure to industrial wind energy's real impacts
Migratory bats hardest hit by wind turbines
Star-Tribune - Christine Peterson - October 30, 2012
Impact on Wildlife Impact on Bats Wyoming
Of Wyoming's 15 resident bat species, three of them are most susceptible to the deadly effects of wind turbines: the hoary bat, the silver-haired bat and the eastern red bat. They are Wyoming's only tree-roosting bats, said Douglas Keinath, senior zoologist with the Wyoming Natural Diversity Database.
Of Wyoming's 15 resident bat species, three of them are most susceptible to the deadly effects of wind turbines: the hoary bat, the silver-haired bat and the eastern red bat.
They are Wyoming's only tree-roosting bats, said Douglas Keinath, senior zoologist with the Wyoming Natural Diversity Database.
Because they roost in trees, they can't protect themselves from the winter cold and wind. This means they are also Wyoming's only migratory bats.
All other bats hibernate, often in caves or mines where they are protected from the elements.
During migration bats seem to suffer most from barotrauma, when changes in pressure near spinning wind turbine blades explodes the capillaries on the edges of bats' lungs. The lungs fill with fluid, and the bats drown, Keinath said.
Hoary, silver-haired and eastern red bats are very light. The hoary, the largest of the three, usually weighs less than one ounce. A robin weighs three times as much even though its wing span is the same size.
The three species also have the most fur of any Wyoming bats. In cool climates, their furry wings wrap around their bodies like sleeping bags, Keinath said.
Here is the breakdown on Wyoming's only... more [truncated due to possible copyright]
Here is the breakdown on Wyoming's only migratory bats, and those most at risk to die of barotrauma.
* Hoary bat: Wyoming's largest bat, its wingspan is more than a foot long. It survives mostly on moths but will also eat large beetles and grasshoppers. Hoary bats roost in conifer trees, often at the edges of clearing. "The bat's size, shape and coloration mimic pine cones," Keinath said.
They are strong fliers and are the most widespread of any American bat. They are also the only bat native to Hawaii. Experts believe the hoary bat flew there from mainland North America.
* Eastern red bat: This small to medium-size bat lives mostly on moths, beetles and mosquitoes. Its wing span is between 11 and 13 inches and it weighs about as much as two nickels. It roosts in leaves of trees and hangs from one foot. "Their size, shape, and red coloration mimic a dead leaf," Keinath said.
* Silver-haired bat: Slightly smaller than the red bat, the silver-haired bat eats small insects such as mosquitoes, flying ants and small moths. Even though it's North America's slowest-flying bat, it is still a strong flier and can migrate long distances. It sleeps in loose bark or cavities of trees.
Source: http://www.redding.com/news...
http://www.windaction.org/posts/35262-migratory-bats-hardest-hit-by-wind-turbines
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The WindAction Group
Lisa Linowes, Executive Director
General Copyright Statement Most of the sourced material posted to WindAction.org is posted according to the Fair Use doctrine of copyright law for non-commercial news reporting, education and discussion purposes. Some articles we only show excerpts, and provide links to the original published material. Any article will be removed by request from copyright owner, please send takedown requests to: info@windaction.org
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Authorities in Vietnam are now granting all U.S. nationals, who travel to the territory for business or tourism purposes, a one-year, multiple entry visa. No formal announcement was made, but the policy took effect on August 28, 2016.
The authority will stop issuing one-month or three-month single/multiple entry visas and one-year multiple entry will be granted automatically upon entry.
The government fee for the new visa is US$ 135 for one-year multiple entry.
Travelers can stay up to a maximum of 90 days on each visit. This remains unchanged.


September 25th 2018 is the release date of "Fall Of The Divine", the new Hell's Crows video taken from their first album "Hell's Crows" released on March 31st 2017 on Valery Recordslabel (www.valeryrecords.com), distributed by Audioglobe www.audioglobe.it/disk.php?code=8032642781605 and the best digital wordlwide stores.
HELL'S CROWS, the Italian melodic-heavy metal band, in collaboration with CROWN METALBooking Agency (www.crownmetal.it) have been involved in the last year and a half around Italy in the promotion of their last studio work, often dividing the stage with colleagues of national and European fame such as PINO SCOTTO, SKW, NECRODEATH, TRICK OR TREAT, SKELETOON, SICK N 'BEAUTIFUL, SOUNDSTORM, EAGLEHEART, STARSICK SYSTEM, SAWTHIS and many others.
The video was directed by Studio Close Up (www.studiocloseup.it) and produced by Studio Close Up (www.studiocloseup.it) and Randy Rush.
The press / promotional office is overseen by the V-PROMOTION Agency (www.v-promotion.com).


text:
from .agent.stateAgent import StateAgent
from . import tools,options

from .dso import DSO
from .tso import TSO
from .retailer import Retailer
from .producer import Producer

## Agent which evaluates quantitatively the state of the system.
class QuantitativeCriteria(StateAgent):

    ## Constructor
    # @param name Name. @see rename()
    def __init__(self,name="Quantitative criteria"):
        StateAgent.__init__(self,name)
        self._users=[]

    def initialize(self, data):
        StateAgent.initialize(self,data)
        data.personal[self.name]['welfare']=[0.0]
        data.personal[self.name]['dsosCosts']=[0.0]
        data.personal[self.name]['protectionsCost']=[0.0]
        data.personal[self.name]['tsosCosts']=[0.0]
        data.personal[self.name]['producersCosts']=[0.0]
        data.personal[self.name]['retailersCosts']=[0.0]
        data.personal[self.name]['statusVariables'].extend(('welfare','dsosCosts','protectionsCost','tsosCosts','producersCosts','retailersCosts'))

    ## Register a user for the quantification.
    # @param name User's name.
    # These users should own the following personal variables:
    #   - costs
    def registerUser(self,name):
        self._users.append(name)

    def act(self,data,layer):
        data.personal[self.name]['welfare']=[0.0]
        data.personal[self.name]['dsosCosts']=[0.0]
        data.personal[self.name]['protectionsCost']=[0.0]
        data.personal[self.name]['tsosCosts']=[0.0]
        data.personal[self.name]['producersCosts']=[0.0]
        data.personal[self.name]['retailersCosts']=[0.0]
        for u in self._users:
            data.personal[self.name]['welfare'][0]-=data.personal[u.name]['costs'][0]
            if isinstance(u, DSO):
                data.personal[self.name]['dsosCosts'][0]+=data.personal[u.name]['costs'][0]
                data.personal[self.name]['protectionsCost'][0]+=data.personal[u.name]['protectionsCost']
            elif isinstance(u, TSO):
                data.personal[self.name]['tsosCosts'][0]+=data.personal[u.name]['costs'][0]
            elif isinstance(u, Producer):
                data.personal[self.name]['producersCosts'][0]+=data.personal[u.name]['costs'][0]
            elif isinstance(u, Retailer):
                data.personal[self.name]['retailersCosts'][0]+=data.personal[u.name]['costs'][0]
        data.personal[self.name]['welfare'][0]-=data.personal[self.name]['protectionsCost'][0]

        if options.DEBUG:
            tools.log("\tWelfare: %s." % (data.personal[self.name]['welfare']), options.LOG, options.PRINT_TO_SCREEN)
            tools.log("\tDSOs costs: %s." % (data.personal[self.name]['dsosCosts']), options.LOG, options.PRINT_TO_SCREEN)
            tools.log("\tTSOs costs: %s." % (data.personal[self.name]['tsosCosts']), options.LOG, options.PRINT_TO_SCREEN)
            tools.log("\tProducers costs: %s." % (data.personal[self.name]['producersCosts']), options.LOG, options.PRINT_TO_SCREEN)
            tools.log("\tRetailers costs: %s." % (data.personal[self.name]['retailersCosts']), options.LOG, options.PRINT_TO_SCREEN)

    ## @var _users
    # List of users to monitor to compute the welfare.
    # These users should own the following personal variables:
    #   - costs

redpajama_set_name: RedPajamaGithub


After 20 years the interior cabin of your car will begin to fade from the sun and different elements. Many times you can not buy hard trim plastics in your factory color. Instead of spending money at repair interior trim shops you CAN redye & repaint your interior at home!
Fbodywarehouse offers a complete line of SEM brand products to assist you in the restoration of your car's interior.


@NABTU : Maryland Governor @GovLarryHogan announced a plan to fund $3.5 billion in school construction projects across the state. This would be the largest investment in school construction in MD history while also resulting in 27000 construction jobs! - JOIN A LABOR UNION - UNION YES !
@NABTU : Maryland Governor @GovLarryHogan announced a plan to fund $3.5 billion in school construction projects across the state. This would be the largest investment in school construction in MD history while also resulting in 27000 construction jobs!
Maryland Governor, @GovLarryHogan, announced a plan to fund $3.5 billion in school construction projects across the state.


Home / Old Try / A month.
Well, it's been a month since we started selling.
And to cap off a great 30 days Mr. Reed of A Trip Down South wrote up a nice post on us. Go there if you'd like to see some more sneak peeks of what we're working on / where we're working on it.
And, while I'm not one to reminisce so soon, I'm going to tell you we've had one heck of a month.
The best part is the support we've gotten from folks.
Below are excepts of some emails we've gotten that can just warm a heart up.
We thank you all & we mean it.


text:
Virgil Bărbuceanu (20 April 1927 – October 2004) was a Romanian equestrian. He competed at the 1956 Summer Olympics and the 1960 Summer Olympics.

Born in Bobaița, Mehedinți County, Bărbuceanu attended high school in Turnu Severin, and graduated in 1952 with the rank of lieutenant from the Cavalry Officer School in Sibiu. He then joined the Army Equestrian Club in Bucharest and later served as colonel in the Romanian Army. In 1986, he founded the Equestrian Base in Piatra Neamț, which now bears his name.

References

External links

1927 births
2004 deaths
Romanian male equestrians
Olympic equestrians of Romania
Equestrians at the 1956 Summer Olympics
Equestrians at the 1960 Summer Olympics
People from Mehedinți County
20th-century Romanian military personnel
Romanian Land Forces officers

redpajama_set_name: RedPajamaWikipedia


The official bicycle of 6'5″, 287 pound, 18 year NFL veteran and 7 time Pro Bowler Lomas Brown and 6'10", 380 pound, 19 year NBA veteran, Piston's power forward and World Champion Rick Mahorn.
WITH A BEEFED UP FRAME, THE ABILITY TO HOLD UP TO 400LBS, AND THE OPTION OF ADDING A 750W OR 1000W MOTOR, THE SAMSON ELECTRIC IS THE PERFECT BIKE FOR PROFESSIONAL ATHLETES LIKE LOMAS AND RICK – OR ANYONE ELSE OVER 300 POUNDS!
Contact your local Day 6 Dealer or give us a call to order the electric Samson.
SEE WHY DAY 6 IS RICK MAHORN'S BICYCLE OF CHOICE!


An entirely new camera system. The brightest, most colourful iPhone display ever. The fastest performance and best battery life in an iPhone. Water and splash resistance.1 And stereo speakers. Every bit as powerful as it looks — this is iPhone 7.
Apple iPhone 8 Plus 64GB - Space..


There was another interesting article from HealthLeaders Media that the nurse staffing factoring specialists at PRN Funding felt would be beneficial for our nurse staffing friends to read. Entitled Nurse Staffing Costs Must Be Weighed Against the Cost of Errors, the article author believes that hospital executives need to pay closer attention to studies that show how nurse staffing affects a hospital's overall performance and base staffing decisions on those findings.
Moreover, Douglas gave an example of looking at things from a bigger perspective. She said that some hospitals that have cut back on staffing may not notice that it is overusing overtime and it might not notice that there's a relationship between the overtime and the number if infections on a unit.


A self leveling compound is a concrete type floor underlayment that is applied to subflooring prior to the installation of tile or wood. Using a self leveling compound is easier than other types of subfloor compounds because it will fill in low spots to make sure that a more complete coverage of the floor takes place. The best time to use a self leveling compound is in conditions that are not too humid or cold in order to allow the compound to set up properly and work as designed.
What Is Self Leveling Compound?
The self leveling compound is a type of quick setting concrete. It is mixed with water into a compound that has a watery consistency. Unlike concrete that is mixed to a consistency of toothpaste or peanut butter, self leveling compound has a consistency that is more like pea soup. This consistency allows you to pour it on the floor and apply it with little work or intervention once the mixture has been prepared.
If the temperature in the room where the self leveling compound is being poured is too hot, it may not properly cure. This may result in a soupy mess on the floor that does not properly level and may need to be cleaned up and poured again. This can be avoided by waiting until the temperatures in the room are less humid or cooler. You may consider using floor fans as a way to bring the temperature down and make the room easier to work in.
If the temperature in the room where the self leveling compound is being poured is too cold, the compound may freeze during the application. This will prevent it from reaching the lower areas of the floor and creating the self leveling effect that you desire. The resulting floor will not be level and you will again find yourself having to remove the material and starting over to achieve a more even or level pour. You can consider using floor heaters and turning up the heat in the room as a way to raise the temperature to a more moderate temperature climate.
When you purchase the self leveling compound for use on the subfloor prior to the laying of a new tile or wood floor, you should check with the manufacturer for any hints or directions on how best to use the material. Following the manufacturer's advice will yield the best results when working with their brand of self leveling compound. Each manufacturer may have specific instructions or directions that should be followed in order to properly use their self leveling compound. Following this advice will help you avoid having to pour the floor again or waste any of the compound because of improper use.
If necessary, ask for advice when purchasing the self leveling compound from the retailer.
The drying time for self-leveling compound varies greatly from one package to the next. The easiest way to check this time would be to look at the installation instructions that accompanied the self-leveling compound. On average, you might have to wait anywhere from 1 to 6 hours for the compound to cure. You must give it ample time to dry completely so it lays flat and remains strong. To speed up drying time and avoid any possible problems, consider some of the tips below.
If you have the chance, just let the self-leveling compound sit overnight. That way you won't have to constantly check if it is dry or not, and the time will seemingly pass a lot faster.
Try to let everything dry in an area that isn't too moist. Humidity will make the process take longer. Obviously you can't control the weather, but try to keep as much moisture out of the area as possible.
Don't blow a fan directly on the self-leveling compound, but you should use one in the room for air circulation. A clean ceiling fan will work fine, as will a fan that sits above the ground. Set it on low or medium speed.
Joist hangers are an important part of the construction of the floor and deck. The hangers reinforce the strength of the joists, keeping the floor strong even as damage sets in over time. Installing masonry joist hangers is not a tasking job, and with the right materials and instructions, you can do it by yourself. At the same time, you need to be careful to avoid mistakes that would compromise the function of your joist hangers. One such mistake is using the wrong size of joist hanger for the joist. Always ensure that you get the right size of hanger guided by the size of the joist. Joist hangers should also not be re-used as this lowers the capacity of load they can support.
Purchasing the right size of joist hangers is the first step in strengthening your floor or deck. Joist hangers are available in different sizes depending on the size of joists. Nails are another important material that you should buy in the right size. Joist hangers usually come with the recommended size of nails that ensure added strength. The nails are long enough to attach to the frame behind the beam for added strength. Galvanized deck screws are unsuitable for joist hangers because they are not of the proper size and strength needed to support joist loads.
Use the tape measure to get the distance across the outer beam. This will help in locating the areas to install the joist hangers. Use the pencil and mark the spacing of the hangers on the beam, which should be spaced 16 inches apart and a ½-inch from the end of the beam.
Take the joist hangers one at a time and put them astride the marks on the beam so that the marks are at the middle of the hangers. Ensure that the hanger is well aligned onto the beam guided by the mark. Then take the hammer together with the nails and firmly fix the hangers onto the beam on both sides.
Since joists usually vary in width, you need to measure the width of each joist first. Depending on the varying width, place each joist hanger at the right height to ensure that the joists are level. Take your joists and fit them into the joist hangers firmly by placing the end of the joists onto the hangers. Take the galvanized nails and use the hammer to drive the nails through the outer beam into the end of the joist.
After securing all the joists with nails, fill in all the nail holes. Leaving the holes unfilled allows the weakening of the joist hangers.
When winter rolls around and your floors turn stone cold, use floor heating mats to take the chill out of going barefoot. Not only will you see heating bills reduced, but you will also get rid of dust and particles that traditional forced air systems spread around the house. There are many pros to electric floor heating mats. Floor mats work like a big electric blanket underfoot.
In the past, it was difficult to install radiant flooring under existing wood or carpet. Usually, heated floor mats were added during construction. Older models often required cement to be installed with the electrical system, but not today. Most floor heating mats on the market are easily installed directly underneath carpet and floating wood.
Note, however, that certain types of tiled flooring will have to be replaced if you want to install heated floor mats. If you are doing a remodel, it would be the perfect time to add radiant flooring under your tile. For the rest of your house, installation should be quick and easy.


Q-ic (Luc Byltiauw), active as DJ and producer since 1996, released his first record in 2000 on the Drought label (Sativae recordings, uk). The real breakthrough followed after his booty remix of 'I Found You', on the Belgian Pocket label (N.E.W.S.) in 2003. Before his career as DJ - producer, Q-ic worked as sound- engineer. At the age of 16, he was a regular sound- engineer for different bands, and from 1992 until 1996 he mixed more than 400 live-performances! He combined this job with his studies into 'Audio-Visual Art' and after his graduation he followed higher education into 'Cinematography' in Brussels. From 1998 until 2003, Q-ic was the driving force behind Creation Tecnologiq, known for their infamous 'AQUA' parties. Bringing several DJ's for the first time to Belgium, made them the founders of a new techno movement in Antwerp. During this period, Q-ic met Axel Stephenson, the guy who recorded legendary tracks like "The first rebirth" and "Love is an ocean". After a year of studio-work, this duo presented their innovating new sound which has been picked up by the majors Virgin and Universal Music! Releases on several renowned labels such Polydor (Universal), Pocket (N.E.W.S), Drought, Horspielmusik, Ghoststyle, Reaktion, ... followed rapidly. In the period from 2004 until 2008, Q-ic claims his place between the Belgian Top DJ's by co-producing some of the biggest names in the techno & jump scene. He releases tracks with Marco Remus (DE), DJ Bam Bam (USA), CJ Bolland, Kamikaze & Mr. Eyez (USA), DJ Ghost, Lethal MG, Coone, Ronald-V, Chicago Zone and many others. This results in several hit releases such as Punk shock, Musique, Fortunate beats, Desire go higher, No Flash, ... and his unique innovating sound becomes Q-ic's trademark. In 4 years Q-ic appears on more than 300 compilat ions and he mixes t he compilat ion CD's of some of the biggest events such as Reverze, Deqon1, Bassleader, Complex, ... Q-ic travels around Europe and he plays at all the major festivals and events such as I Love Techno, Love Parade, Nature One, Defqon1, Ruhr in Love, City Parade, Decibel Outdoor, Hardbass, Frequence Festival, Reverze, Bassleader, Emporium, ... Beside his guest performances, Q-ic playes every Saturday as resident DJ at club Complex. In 2009, Q-ic becomes A&R manager at Zoo Records and he starts up his own publishing house called 'Q-ic Music'. To support the new generation producers in the tek- and jumpstyle scene, Q-ic makes 2 new sublabels at Zoo Records: "Fanatix" & "Sur+". In this way Zoo Records will represent all harder styles. If you would ask Q-ic to define his DJ sets or productions in one word, it would be: diversity! He does not want to limit himself to one style; therefore he integrates his specific sound into different musical genres. Q-ic performed extensively in Europe playing jumstyle, French tek & techno sounds.
Toneshifterz Meetz Nitrouz, Psyko Punkz, The Pitcher, MC Renegade, Headhunterz, Coone, Max Enforcer, Noisecontrollers, Wildstylez, Frontliner, Frequencerz, Blutonium Boy, Sound Freakerz, Zatox, Tatanka, B-Front, Ran-D, Fenix, Lethal MG, Playboyz, Dr Phunk, Dr Rude, Demoniak, Detektor, Mode Seven, Stephan Strube, Shaytek, Q-IC, Itraxx, Bestien, Royal S, Miss Faction, Junior Waxx, D-vision, Def Toys, DJ Liberty, Pat B, Trent Easton, Gave, Dalora, Various Artists.


Please Note: Children must be accompanied by an adult at this event.
This is going to be good….really good ! Paul Cookson has sold over one million books, worked with thousands of schools, played at festivals galore and rip-roariously entertained folks of all ages with his laugh out loud poetry antics for over 30 years. Tonight Paul presents his 100 mile an hour family-friendly audience participatory "Joke Shop Poetry Show" - with added ukuleles. Getting involved is non negotiable and anything could and probably will happen. Bring your family and settle in for a cracking time. It'll be like pantomime but with better rhymes!
As a poet and performer Paul has worked with such luminaries as Henry Normal, Lemn Sissay, Roger McGough and Ian McMillan. He counts amongst his titles being Slade's 'poet laureate' and is currently the Poet in Residence for The National Football Museum - perhaps he'll compose a lament for our local football teams!


Ergon Energy is one of Australia's largest electricity companies.
With increasing awareness of sustainability issues in the corporate environment, there has been growing pressure on Ergon Energy to be able to demonstrate its sustainability credentials in a transparent and complete manner. EcoSTEPS helped develop the corporate sustainability framework best suited to Ergon Energy's needs.
EcoSTEPS worked as a 'critical friend'. We helped to integrate existing projects, programs, strategic planning structures to build a more synergistic platform for growth and continuous improvement. Gaps were identified that highlight opportunities to deliver significant first-mover advantage.
How can my organisation improve its sustainability performance? To find out how EcoSTEPS can help you, please contact us.


text:
Calls for proposals – Closed
New Strategic Programmes for NOFIMA 2021-2024
Published 16 Mar 2020
Application typeSupport from Other Funders
Application deadline25 May 2020, 11:00 CEST
Relevant thematic areas for this callLand-based food, the environment and bioresources
Target groupsResearch organisations
Funding scaleNOK 50 000 000-90 000 000
Amount of funding presumed available for this call for proposalsNOK 300 000 000. The board of Research Funding for Agriculture and the Food Industry has decided to issue a call for proposals with a budgetary framework of NOK 300 million for strategic institute programmes for Nofima.
Project duration48-48 months
Contact for the call
Mona Gravningen RyghMat og bioøkonomimgr@forskningsradet.no+4722037318+4797630301
Download the call
New Strategic Programmes for NOFIMA 2021-2024.pdf
Project description template Researcher Projects NOFIMA.docx
Date call is made active
Application submission deadline
Earliest permitted project start
Latest permitted project start
Latest permitted project completion
The purpose of this call is to register applications for the period 2021–2024 for new strategic programmes for Nofima.
About the call
Who is eligible to apply?
Who can participate in the project?
What can you seek funding for?
Scientific articles and research data
Relevant thematic areas
Land-based food, the environment and bioresources
Requirements for this application type
About the call for proposals
The general principles guiding the Research Funding for Agriculture and the Food Industry (Foundation for Research Levy on Agricultural Products (FFL) and the Agricultural Agreement Research Fund (JA)) involve follow-up of the agricultural policy objectives set out in the white paper on agricultural and food policy (in Norwegian only: Endring og utvikling – En fremtidsrettet jordbruksproduksjon (Meld. St. 11 (2016–2017)) and in the recommendation concerning the white paper (in Norwegian only).
The Foundation for Research Levy on Agricultural Products (FFL) was established pursuant to the Act relating to research duties on agricultural products to ensure the economic basis for research related to agricultural products. The FFL's funds come from research duties levied on Norwegian-produced and imported agricultural products. The board takes decisions on the basis of statutes issued by the Ministry of Agriculture and Food.
Based on these statutes, the FFL has a special responsibility for funding agricultural research at Nofima. This is carried out in part through allocations to the institute's strategic programme initiative.
Grant applications are assessed on the basis of research quality in keeping with the Research Council's guidelines.
The Norwegian-language call for proposals is the legally binding version.
This call for proposals is only open to grant applications from Nofima.
Requirements relating to the Project Owner
The research organisation is to be entered as the Project Owner in the application form, and must have authorised the submission of the grant application.
Requirements relating to the project manager
To qualify as project manager, individuals must hold an approved doctorate or have obtained qualifications at associate professorship level before the date of the application submission deadline. In this context, current or previous employment in the Norwegian research institute sector in a position as forsker 1 (research professor), forsker 2 (senior researcher) or seniorforsker (senior researcher) is considered equivalent qualification.
Requirements relating to partners
Only research organisations are eligible to be partners and receive funding via the research project.
Other types of organisations, such as companies and other undertakings, are not eligible to receive support and may not be project partners, but they may serve as suppliers of R&D services to the project. In such cases, the intellectual property rights related to the result of the supplier's work activities will become the property of the institution procuring the services.
Requirement to incorporate user involvement
The project is required to incorporate user involvement. Grant proposals must explain who the relevant users are for the given project, and how they will be involved in the planning and implementation of the project and application of the results.
It is important that the anticipated benefits of the project are based on user needs and documented knowledge gaps within the thematic areas described in the text of the call. Both short- and long-term impacts and outcomes are to be described in the grant application.
Please see the webpage on "What to enter in the project budget" for details and important information.
Operating expenses, including procurement of R&D services, costs related to the operation and depreciation of scientific equipment, and other operating costs.
Payroll expenses: For academic personnel in the university and university college sector and all doctoral and post-doctoral fellowships in Norway the following rates are to be used. You may apply for funding to cover the following positions:
Doctoral research fellowships for up to three years and post-doctoral research fellowships for up to three years. The amount sought must follow the Research Council's rates for doctoral and post-doctoral fellowships.
Hiring procedures, employment periods, work duties, education plans, etc., must comply with the regulations concerning terms and conditions of employment for the posts of post-doctoral research fellow, research fellow, research assistant and resident laid down by the Ministry of Education and Research.
Academic positions.
Conditions for funding
Companies will not be eligible to receive support to cover projects costs.
The Project Owner (research organisation) is responsible for selecting the archiving solution(s) to use for storing research data generated during the project. The Project Owner must specify the planned solution(s) in connection with the revised grant proposal.
Reporting and disbursement of funding
Funding will be disbursed in arrears, and only actual expenses entered in the institution's accounts will be covered. All reports are to be submitted online.
Relevant thematic areas for this call
The topics addressed under this call are defined based on the project outlines reviewed by the board of Research Funding for Agriculture and the Food Industry. The topics must be followed up in the application.
Food - Green sector, Food - Blue-green sector, Safe food value chain, Food, health and well-being
Grant applications are to be based on a project outline submitted to the FFL by the 17 January 2020 deadline.
You may revise and resubmit your grant application form multiple times up to the application submission deadline. We recommend that you submit your application as soon as you have filled in the application form and included all mandatory attachments. After the deadline, it is the most recently submitted version of the grant application that will be processed.
The grant application, including all attachments, must be submitted in English.
All attachments must be uploaded in PDF format.
Grant applications must fulfil the intentions and objectives of Nofima Mat.
Grant applications must include plans for how important users (in industry, society, research and public administration) will be incorporated into/take part in dissemination activities for the project.
The role and tasks of each project partner must be clearly described.
The project summary must address all key points in the grant application, as the project summary will be a central component of the decision-making process.
The project title, project summary and overall objectives must be submitted in Norwegian as a separate attachment of maximum one page.
To be eligible for funding the project must start on 1 January 2021 and funding for 2021 must be sought from the Research Council. The latest permitted project completion date is 31 December 2024.
Mandatory attachments
A project description of maximum 15 pages using the designated template, found at the bottom of this page.
A CV of maximum 4 pages for the project manager using the designated template, found at the bottom of this page.
Applications that do not satisfy the above requirements will be rejected.
Optional attachments
CVs for key project participants;
A proposal for up to three referees who are presumed to be impartial and qualified to review the grant proposal.
Links to websites and documents, as well as other attachments than those specified above, will not be included in the application review process. There is no technical validation of the content of the attachments you upload, so please make sure that you upload the correct file for the selected type of attachment.
The extent to which the proposed work is ambitious, novel, and goes beyond the state-of-the-art
• Scientific creativity and originality.
• Novelty and boldness of hypotheses or research questions.
• Potential for development of new knowledge beyond the current state-of-the-art, including significant theoretical, methodological, experimental or empirical advancement.
The quality of the proposed R&D activities
• Quality of the research questions, hypotheses and project objectives, and the extent to which they are clearly and adequately specified.
• Credibility and appropriateness of the theoretical approach, research design and use of scientific methods. Appropriate consideration of interdisciplinary approaches.
• The extent to which appropriate consideration has been given to ethical issues, safety issues, gender dimension in research content, and use of stakeholder/user knowledge if appropriate.
Potential impact of the proposed research
• Potential for academic impact:
The extent to which the planned outputs of the project address important present and/or future scientific challenges.
• Potential for societal impact (if addressed by the applicant):
The extent to which the planned outputs of the project address UN Sustainable Development Goals or other important present and/or future societal challenges.
• The extent to which the potential impacts are clearly formulated and plausible.
Communication and exploitation
• Quality and scope of communication and engagement activities with different target audiences, including relevant stakeholders/users.
The quality of the project manager and project group
• The extent to which the project manager has relevant expertise and experience, and demonstrated ability to perform high-quality research (as appropriate to the career stage).
• The degree of complementarity of the participants and the extent to which the project group has the necessary expertise needed to undertake the research effectively.
The quality of the project organisation and management
• Effectiveness of the project organisation, including the extent to which resources assigned to work packages are aligned with project objectives and deliverables.
• Appropriateness of the allocation of tasks, ensuring that all participants have a valid role and adequate resources in the project to fulfil that role.
• Appropriateness of the proposed management structures and governance.
Overall assessment of the referee/panel
Overall assessment of the referee/panel based, on the criteria Excellence, Impact and Implementation.
Relevance to the call for proposals
The extent to which the project satisfies the guidelines and stipulations set out in the call for proposals.
All grant applications will be assessed by international referee panels. Once the panel assessments are completed, the grant applications will be assessed in relation to their relevance to this call. Assessment of the relevance criterion will be carried out by the Research Council in cooperation with the FFL Secretariat. The Research Council administration will then submit its recommendation to the allocating body. The allocating body is responsible for the final decision regarding the approval or rejection of grant proposals.
The final decision regarding funding is expected to be announced end of October/beginning of November 2020.

redpajama_set_name: RedPajamaCommonCrawl


text:
"""
Separate a single genbank file with lots of entries into a directory of single files.
"""

import os
import sys
import argparse
import gzip
import re

if __name__ == '__main__':
    parser = argparse.ArgumentParser(description="Separate a single genbank file with lots of entries into a directory of single files")
    parser.add_argument('-f', help='genbank file to separate', required=True)
    parser.add_argument('-d', help='output directory to write to', required=True)
    parser.add_argument('-v', help='verbose output', action="store_true")
    args = parser.parse_args()

    if not os.path.exists(args.d):
        os.makedirs(args.d)

    if args.f.endswith('.gz'):
        fin = gzip.open(args.f, 'rt')
    else:
        fin = open(args.f, 'r')

    out = None

    for l in fin:
        if '//' == l:
            if out:
                out.write(l)
                out.close()
                out = None
            continue
        if 'LOCUS' in l:
            if out:
                out.close()
            m=re.match('LOCUS\s+(\S+)', l)
            outfilename = m.groups()[0]
            if not outfilename:
                sys.stderr.write("FATAL: Could not parse a filename from {}".format(l))
                sys.exit(-1)
            outfilename += ".gbk"
            if args.v:
                sys.stderr.write("Writing to {}\n".format(outfilename))
            out = open(os.path.join(args.d, outfilename), 'w')
        if out:
            out.write(l)
        elif args.v:
            sys.stderr.write("SKIPPED: {}".format(l))


text:
Syphilitic uveitis and optic neuritis in Sydney, Australia
Luke C Northey Save Sight Institute, Discipline of Ophthalmology, Sydney Eye Hospital Campus, The University of Sydney, Sydney, Australia PubMed articlesGoogle scholar articles
Simon E Skalicky Save Sight Institute, Discipline of Ophthalmology, Sydney Eye Hospital Campus, The University of Sydney, Sydney, Australia PubMed articlesGoogle scholar articles
Avinash Gurbaxani Save Sight Institute, Discipline of Ophthalmology, Sydney Eye Hospital Campus, The University of Sydney, Sydney, Australia PubMed articlesGoogle scholar articles
Peter J McCluskey Save Sight Institute, Discipline of Ophthalmology, Sydney Eye Hospital Campus, The University of Sydney, Sydney, Australia PubMed articlesGoogle scholar articles
Correspondence to Professor Peter J McCluskey, Save Sight Institute, G.P.O. Box 4337, Sydney, NSW 2001, Australia; peter.mccluskey{at}sydney.edu.au
Northey LC, Skalicky SE, Gurbaxani A, et al
British Journal of Ophthalmology 2015;99:1215-1219.
Received September 20, 2014
Revised January 12, 2015
Accepted March 4, 2015
First published March 18, 2015.
Online issue publication
Previous version (18 March 2015).


Intervening on Normal: Trauma, Substance Use, and Counselling in Appalachia will be presented by Darlene Vaughn at the Landcare meeting on Monday, March 18th, 7 pm at the LandCare office.
Services and Counseling for Lindsey Wilson College, School of Professional Counseling.
has published poetry, a book chapter, and journal article.
privilege of growing up with many impoverished Appalachian experiences and rich traditions.
College in Columbia, Kentucky in May 2019.


text:
← Owais Talaat Waheed, Ph.D. (On Leave)
Muhammad Mobeen Movania, Ph.D. →
Ayaz ul Hassan Khan, Ph.D. (On Leave)
Dhanani School of Science & Engineering
ayaz.hassan@sse.habib.edu.pk
Ph.D. in Computer Science and Engineering, King Fahd University of Petroleum and Minerals, Saudi Arabia.
M.S. in Computer Science, Lahore University of Management Sciences (LUMS), Pakistan.
BCIT (Computer Science and IT), NED University of Engineering and Technology, Pakistan.
Oracle Certified Professional (OCP) DBA Track
Microsoft Certified Technology Specialist
Strategic Time Management
Strategic Visions
Strategic Negotiation Skills
Vision Retreat
SAP: Introduction to ABAP Programming Course
SAP Basics Course
4MAT Instructional Design Training
Fundamentals of Accelerated Computing with CUDA C/C++ (NVIDIA Deep Learning Institute)
DLI Platform Course for Instructors (NVIDIA Deep Learning Institute)
NVIDIA DLI Certified Instructor
NVIDIA DLI University Ambassador
Parallel and Distributed Computing
Parallel Computing (MS/PhD Level)
GPGPU Programming (MS/PhD Level)
Concepts of Algorithms and Computer Programming
Assembly Language
Discrete Structures
Distributed Systems (MS Level)
Assistant Professor, College of Computing and Information Sciences, Karachi Institute of Economics and Technology, Spring 2018 to Fall 2019.
Assistant Professor, Computer Science Department, Qassim University, Fall 2015 to Fall 2017.
Conducted Training
CUDA Programming
4MAT Instructional Design (For Faculty)
Enhancing the Efficiency of Massively Parallel Programs in Computational Science and Engineering Applications, Funded By: King Abdulaziz City of Science and Technology, Saudi Arabia (Project No. 12-INF-3008-04), (Project Budget: SAR 955,000)
Enhancing the Efficiency of Deep Learning in Big Data Analytics, Funded By: Deanship of Scientific Research, Qassim University (Project No. 1374-coc-2016-1-12-S), (Project Budget: SAR 50,400)
Dr. Ayaz is a skilled techno master and an accomplished computer scientist. With a diverse experience of 15 years in industry and academics, he contributed positively to several universities and professional organizations with his excellent problem-solving skills. As a technology professional, he is experienced to deal with many international clients including Dubai Financial Market, Dubai Municipality, Emirates, Comets Services, Doha Securities Market, Tensator UK, CreditOne Bank of USA, Quadrem Global Supply Chain Solutions, American Honda Motor Company, BMW, Nautilus Incorporation, Bentley Motors, At&T, and VolksWagen to provide them cutting edge solutions for their day-to-day business processes. Some examples of his services include development of Queuing Management Systems, Online Ticker Systems, Self-Service KIOSKs, ETL processes and reporting, etc.
As a computer scientist with interest in high performance computing, parallel programming, and deep learning, he is an author of 20+ publications in reputed journals and conferences along with a book on parallel processing. He has successfully completed several research funded projects and few more are in process of accumulated worth of about half a million dollars.
Dr. Ayaz ul Hassan Khan holds PHD degree in Computer Science and Engineering from King Fahd University (Saudi Arabia), Bachelor of Computer Science and Information Technology from NED University (Pakistan) with secured 2nd position (90%) and MS Computer Science from Lahore University of Management Sciences with 3.61 CGPA. In addition to these, he possesses a dozen of professional certifications for various technical and soft skills.
Dr. Ayaz is an occasional traveler at both local and international level. He has travelled 60+ cities of 7 countries in 3 different continents. He has achieved a Local Guide – Level 6 on Google maps with 5 star rating and accumulated 1553 points for his travel contributions.
Selected Conferences
Mayez A. Al-Mouhamed, Ayaz H. Khan, and Nazeeruddin Mohammad, "A Review of CUDA Optimization Techniques and Tools for Structured Grid Computing", Computing Journal, Springer, First Online, doi: https://doi.org/10.1007/s00607-019-00744-1, Jul 2019 [Link]
Mayez Al-Mouhamed and Ayaz H. Khan, "SpMV and BiCG-Stab Optimization for a Class of Hepta-Diagonal Sparse Matrices on GPU", The Journal of Supercomputing, pp 1-35, Published Online 24 Mar 2017, DOI: 10.1007/s11227-017-1972-3 [Link]
Ayaz H. Khan, Mayez Al-Mouhamed, Muhammed Al-Mulhem, and Adel F. Ahmed, "RT-CUDA: A Software Tool for CUDA Code Restructuring", International Journal of Parallel Programming, pp 1-44, Published Online 13 May 2016, DOI: 10.1007/s10766-016-0433-6
Ayaz ul Hassan Khan, Mayez Al-Mouhamed, Allam Fatayer, and Nazeeruddin Mohammad, "Optimizing the Matrix Multiplication Using Strassen and Winograd Algorithms with Limited Recursions on Many-Core", International Journal of Parallel Programming, Vol. 44, No. 4, 2016, pp 801-830. DOI: 10.1007/s10766-015-0378-1
Mayez Al-Mouhamed, and Ayaz ul Hassan Khan, "Exploration of Automatic Optimisation for CUDA Programming", International Journal of Parallel, Emergent, and Distributed Systems (IJPEDS), Vol. 30, No. 4, 2015, pp 309-324. DOI: 10.1080/17445760.2014.953158
Basem Al-Madani, Ayaz ul Hassan Khan, and Zubair A. Baig, "A Novel Mobility-Aware Data Transfer Service (MADTS) Based on DDS Standards", The Arabian Journal of Science and Engineering, Vol. 39, No. 4, 2014, pp 2843-2856. DOI: 10.1007/s13369-014-0944-7
A. H. Khan, T. Kazmi, and N. Majeed, "Conflict – Free Replication Datatype using Data Distribution Service", Proceedings of 3rd Asian Conference on Science, Technology and Medicine, Dubai UAE, Feb-2019.
Ayaz ul Hassan Khan, Mayez Al-Mouhamed, and Allam Fatayar, "Optimizing Strassen Matrix Multiply on GPUs", 16th IEEE/ACIS International Conference on Software Engineering, Artificial Intelligence, Networking and Parallel/Distributed Computing (SNPD 2015).
Ayaz ul Hassan Khan, Mayez Al-Mouhamed, and Lutfi A. Firdaus, "Evaluation of Global Synchronization for Iterative Algebra Algorithms on Many-Core", 16th IEEE/ACIS International Conference on Software Engineering, Artificial Intelligence, Networking and Parallel/Distributed Computing (SNPD 2015).
A. H. Khan, M. A. Al-Mouhamed, A. Almousa, A. Fatayar, A. R. Ibrahim, and A. J. Siddiqui, "AES-128 ECB Encryption on GPUs and Effects of Input Plaintext Patterns on Performance", 15th IEEE/ACIS International Conference on Software Engineering, Artificial Intelligence, Networking and Parallel/Distributed Computing (SNPD 2014), Las Vegas, USA. [link]
A. H. Khan, M. A. Al-Mouhamed, A. Almousa, A. Fatayar, A. Baqais, and M. Assayony, "Padding Free Bank Conflict Resolution for CUDA-Based Matrix Transpose Algorithm", 15th IEEE/ACIS International Conference on Software Engineering, Artificial Intelligence, Networking and Parallel/Distributed Computing (SNPD 2014), Las Vegas, USA. [link]
DSSE Faculty
Syeda Saleha Raza, Ph.D.
Tariq Kamal, Ph.D.
Muhammad Nadeem, Ph.D. (On Leave)
Sajal Sohail Rana, M.A.
Maria Samad, MA.Sc
Muntazir Abidi, Ph.D.
Aeyaz J. Kayani, Ph.D.
Muhammad Umer Tariq, Ph.D.
Muhammad Mobeen Movania, Ph.D.
Owais Talaat Waheed, Ph.D. (On Leave)
Muhammad Qasim Pasta, Ph.D.
Faisal Alvi, Ph.D.
Abdul Basit Memon, Ph.D.
Mohammad Shahid Shaikh, Ph.D.
Farhan Khan, Ph.D.
Neelma Bhatti, Ph.D.
Aatyka Fatima, M.S.
Areeba Aziz Rajput, M.S.
Mohammad Salman, M.Eng
Haleema Qamar, Ph.D.
Anzar Khaliq, Ph.D.
Aamir Hasan, Ph.D.
Sameena Shah Zaman, Ph.D.
Shafayat Abrar, Ph.D.
Abdul Samad, Ph.D.
Ahmad Usman, Ph.D.
Hassaan Furqan Khan, Ph.D.
Humaira Jamshed, Ph.D.
Humaira Qureshi, Ph.D.


text:
Course Title: Designing Policy
POLI1089
Course Coordinator: Peter Norden
Course Coordinator Email:peter.norden@rmit.edu.au
Course Coordinator Location: 37.4.12
This course is a third year core social science course that introduces you to the role played by key values and ethical ideas like justice, individual rights, respect, fairness, and truth-telling, in both making and implementing public policy. The course is designed to introduce you to something of the traditions of ethical debate in the West, the key vocabulary deployed in rational value analysis, the discernment and critical evaluation of the role played by certain values in a range of contemporary policies and the development of innovative policy ideas that draws on alternative values to those currently informing social and public policy.
By the end of this course you will be able to: use the vocabulary of a number of ethical traditions and to identify, analyse, evaluate and compare the role played by a number of values (like 'good' and 'bad', 'justice', 'respect', deliberative democracy', 'truth-telling' and 'equity') in a longer tradition of ethical and political debate and discussion in the West; to identify this values and ethical vocabulary at work in contemporary policy making and programs and to understand and show how these values shape the kind of policies under examination, and/or be able to identify the issues involved in a policy or professional dilemma where competing values and interests are at stake, such as a case of organisational malfeasance and the risks associated with 'whistleblowing'.
You will be able to engage in a variety of lectures and smaller classes.
You will be able to use a prescribed text.
You will be able to prepare assessment tasks with a total word length or equivalent of 4,000 words.


CHARLESTON, W.Va. (AP) — West Virginia residents can ski or snowboard for free at three state resorts on Sunday.
The West Virginia Ski Areas Association says in a news release the offer involves most of the trail systems at Canaan Valley Ski Area, Snowshoe Mountain and Winterplace Ski Resort.
Skiers must show proof of state residency.
Sunday will mark the last day of the ski season at Canaan Valley. Snowshoe Mountain plans to close its slopes on March 31. Winterplace has not determined a closing date for the season.


text:
You're staying here
Coach John Bunting and his team showed an incredible amount of improvement this year, which is why he deserves a contract extension.
November 23, 2004 | 12:00am EST
Football coach John Bunting experienced two personal victories Saturday. One was beating Duke in convincing fashion to reclaim the Victory Bell, which the Blue Devils snatched away from the Tar Heels last season.
The second was a Saturday announcement by UNC Chancellor James Moeser that he would recommend a two-year contract extension for Bunting to the University's Board of Trustees. Any rumors about Bunting's job going to someone else next year effectively have been quashed.
Though the last two seasons were trying, Bunting certainly earned the extension this year. UNC crossed the finish line with a 6-5 record overall and a 5-3 record in the ACC. This is the first year since 2001 that the Tar Heels have been eligible for a bowl game, which will translate into more money and publicity for the program and the University.
The amazing upset win against Miami on Oct. 30 was the first time that a UNC football team has ever beaten an opponent ranked among the top five teams in the nation - it is sure to go down in history as one of the football program's greatest achievements.
After throwing in a satisfying win against N.C. State in a contest that went down to the wire, a strong performance in the Virginia Tech game and the crushing 23-point victory against Duke this past weekend, the season has turned out to be pretty good.
UNC's five losses were to good teams, and for the most part, they were nothing to be ashamed of. Utah, which thrashed the Tar Heels, has finished the regular season undefeated. Virginia, Louisville, Florida State and Virginia Tech are all bowl-bound.
Although UNC is improving, there are still a number of areas that need polishing, such as the defensive line. But the team has come such a long way in a relatively short amount of time that this past season has been nothing short of miraculous.
This season saw more wins for UNC than the last two combined. Even if the bar was pretty low to begin with, the team and its coaches have shown remarkable progress.
Bunting has shown that he deserves more time to try to take the team even further. The players obviously have responded well to him, so it's reassuring that administrators likely will do the same.
To get the day's news and headlines in your inbox each morning, sign up for our email newsletters.
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The National Institute of Nursing Research hosted a two-day Summit to gather a variety of stakeholder perspectives on the spectrum of caregiving issues and research for conditions and illnesses that may occur across the lifespan.
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text:
CM Punk, Bryan Danielson, NXT, WWE Videos, Rhodes, PWG, Dark, Roman Reigns, McIntyre, Ric Flair, Lethal - Tuesday #2 (5 ET)
Tues. #1 is HERE. To help out the site subscribe to Mistah MegaManFan or support us on Patreon. Don't miss all of today's news updates! With the cheap plugs out of the way here's Tuesday's latest wrestling news.
Both CM Punk and Bryan Danielson are scheduled for matches on AEW Dynamite this Wednesday. Here's the current card. (AEW)
* Battle of the two undefeated teams: Gunn Club vs. Sting & Darby Allin
* Bryan Danielson vs. Alan "V" Angels
Tonight's announced NXT 2.0 lineup is below. (WWE)
* WarGames Advantage Ladder Match: Opponents determined by WWE fan poll
* WarGames Advantage Ladder Match: Dakota Kai vs. Kay Lee Ray
* Kyle O'Reilly & Von Wagner vs. Legado del Fantasma (winning team will receive NXT tag team title shot)
* Joe Gacy invites you to his all-inclusive invitational
* Cameron Grimes vs. Andre Chase
The Cody Rhodes reality series Rhodes to the Top has been renewed for a second season on TNT. (WO)
PWG is bringing back the Battle of Los Angeles on January 29th and 30th.
Three matches have been added to AEW Dark at 7 PM ET on YouTube. (AEW)
* Ray Jaz vs. Infinito
* Leyla Hirsch vs. Sahara Seven
* Aaron Solo & Nick Comoroto vs. Varsity Blonds
Roman Reigns & The Usos faced Drew McIntyre & The New Day in a post-Raw dark match. McIntyre won the match with a Claymore Kick. (PWI)
Ric Flair talks about his trademark dispute with WWE: "I owned the trademark 'To Be the Man,' if I own that trademark and then they use that trademark to create 'The Man' (for Becky Lynch), which has been my label my entire career. I thought it up, it's mine and I own it and I'm one of the few guys that own my intellectual property. Steve doesn't own Stone Cold, believe it or not, I don't think it's right and he should have it but when they get a hold of it, they're going to keep it. They have their reasons and I'm not the one making those calls. I own my stuff."
New Ring of Honor videos are available below.
In this interview Jeff Jarrett talks about AEW signing Jay Lethal: "As the proverbial saying goes, when one door closes another one opens and I could not be happier for my man, Jay Lethal I could not be happier. He is one of the guys that I would be asked, 'who is out there on the Ring Of Honor roster?' Or really just out there. But Jay always re-upped with those guys and he had a sense of loyalty, so hats off to him. But I believe, and my track record speaks for itself when I was part of a decision-making team, Jay has unbelievable talent. He's diverse, he can not just get it done in the ring, he can tell a story in the ring so many different ways, but he can talk. His impersonations are hilarious but they're compelling. But that just shows sort of the range, like a singer. Jay can do a lot of things, and he can do a lot of things well. So I could not be happier for him."
Rok-C will make her promotional debut at MLW Blood & Thunder.
Last week's Impact Wrestling on AXS did all time lows for the show -- a 0.01 18-49 demo and 48,000 viewers -- but hardly surprising given it was on Thanksgiving night. (Wrestlenomics)
Speaking of Impact here's a press release.
IMPACT Wrestling World Champions Hit Dallas
MEDIA TOUR IN ADVANCE OF HARD TO KILL PAY-PER-VIEW ON JAN. 8
IMPACT Wrestling World Champion Moose and IMPACT Wrestling Knockouts World Champion Mickie James will be in Dallas for a two-day Media Tour, December 8-9, in advance of the annual HARD TO KILL pay-per-view, which is scheduled for Saturday night, January 8, originating from The Factory in Deep Ellum.
Moose is in his first World Championship title reign after winning the championship on October 23rd at the Bound For Glory pay-per-view in Las Vegas. Also that night, Mickie James defeated Deonna Purrazzo to win the Knockouts World Championship, marking her fourth reign with the Knockouts title.
Moose & Mickie James will be in Dallas and appearances around the DFW area.
Quinn Ojinnaka, the real-life Moose, played for four teams over seven seasons in the National Football League, including the New England Patriots. His NFL career included time as teammates with legendary quarterback Tom Brady while playing for one of the best NFL head coaches in history, Bill Belichick.
An offensive tackle/guard, Ojinnaka played in 62 NFL games after playing at Syracuse University. He was selected in the fifth-round of the 2006 NFL Draft by the Atlanta Falcons.
Moose transitioned to pro wrestling in 2012. He and Bill Goldberg are the only former NFL players from the modern era to have gone from the NFL to become a pro wrestling World Champion.
In fact, only a handful of football stars in history have ever gone on to win a pro wrestling World Championship. The others are Bronko Nagurski, who is a charter member of the Pro Football Hall of Fame, along with Ernie Ladd, Dick the Bruiser and Gus Sonnenberg.
Sports Illustrated on November 17th spotlighted Moose and his record-setting journey from the NFL to IMPACT World Champion at http://tinyurl.com/r8hdutuy .
Mickie James is one of the most accomplished and decorated female wrestlers of the past two decades. She is a five-time WWE Women's Champion and a two-time winner of Pro Wrestling Illustrated's Woman Wrestler of the Year Award. She also has been ranked No. 1 of the top 50 female wrestlers in the PWI Female 50.
Mickie is an accomplished country music singer, well-known for her single "Hardcore Country," which is used as her wrestling entrance music.
Mickie is an inductee into The Native American Music Awards Hall of Fame and winner of "Best Single Recording" for her song "Left Right Left" at the Native American Music Awards.
A full list of the matches for the HARD TO KILL pay-per-view will be announced over the coming weeks on IMPACT's flagship weekly TV show, Impact!, airing every Thursday night (8-10 p.m. ET) on AXS TV and on IMPACT Wrestling's YouTube Membership.
Both Moose and Mickie James will be in action at HARD TO KILL.
And here's a new vlog from the Good Brothers.
1:00 PM ET. Trish Stratus will host a live event for WWE on Dec. 29th when they come to Toronto.
Danhausen says his leg is doing much better post surgery.
2:00 PM ET. Will Ospreay says nothing can stop him from being at Wrestle Kingdom 16 and New Japan President Takami Obari seemed to confirm the same -- saying that even though foreigners are barred from Japan due to the new COVID strain, those who already have work visas previously would be allowed to enter the country.
Mick Foley is warning people he will NOT be in Philadelphia on Dec. 11th and that any indication to the contrary is false advertising. He's already booked for Irving, Texas on the same day and obviously can't be in two places at once.
Dustin Rhodes recalls his blade job from AEW Double or Nothing 2019 in a match with his brother Cody: "We didn't do that in WWE, unless you got busted open by the corner of the post or something for real. It was a hard way bleeding. It had been a long time and I was out of practice, let's put it like that. I went deep, I hit a vein and it was excessive. I was actually scared at one point, and Cody looked at me and said 'are you okay?' I said 'yeah, I'm fine.' But I'm looking down, and I've looked at the pictures from some of the photographers that took the shots. And they've caught it in mid stream where the thing is shooting out, and it's dripping out of my head. And it's constant; it did not stop. It would not stop and I'm like 'holy shit.' At one point, where I gave Cody a top rope superplex, we almost fell. We almost fell, and it was because I was dizzy and it was slippery up there. It was like 'we've got to go now.' If I had waited another second, I would've superplexed him onto the rope, so we would've landed kind of diagonal onto the ropes. And it wouldn't have been good. It might've created some problems."
Bryan Danielson talks about his lack of AEW merch: "So AEW came up with a very nice 'The American Dragon Is Back' t-shirt. I think one of the things that has confused their merchandising people, and also confused the WWE merchandising people, is that I don't wanna sell people things. So it's a choice. It also makes my life simpler in the sense of I don't have to worry about what I'm going to wear to tv right now. So it's a white shirt and some joggers. There's Steve Jobs who was infamous for, he would just do the black turtleneck and he didn't have to worry. I don't wanna waste my time thinking about what I'm going to wear. Anyways, there's a certain aspect of that but part of my service is this idea of how do we benefit the planet and all that kind of stuff. One of the things that is hard for me is 'okay, if I'm trying to sell people stuff, am I actually trying to help the issues that are facing the world today, especially from a climate/environment perspective?' There are some places that need stuff, so it's like when you say consume less it's like 'what about the people in the forest countries of the world? What about the bottom one billion?' I'm not telling them to consume less. But I also don't want to be pushing people to consume more. I don't want to say 'hey, buy my shirt!' unless purchasing the shirt does more good than harm."
4:00 PM ET. Jake Hager says he's never working for or with Josh Barnett: "I would definitely want to dabble into anything wrestling, especially without striking. Getting punched just sucks, it just does. I would definitely want to dabble in that, but if you're talking about a certain guy's promotion, I'm not working with that guy. Desperation is a stinky cologne Renee, and everyone wants to be a pro wrestler."
The updated Final Battle 2021 card is below. (ROH)
* ROH World Title: (c) Bandido vs. Jonathan Gresham
* ROH Tag Team Titles: (c) The OGK (Matt Taven & Mike Bennett) vs. The Briscoes (Mark & Jay Briscoe)
* ROH Pure Title: (c) Josh Woods vs. Brian Johnson
* ROH Six-Man Tag Team Titles: (c) Shane Taylor Promotions vs. The Righteous
* ROH Women's Title: Rok-C (c) vs. Willow or Mandy Leon
* Shane Taylor vs. Kenny King
Kairi Sane is opening her own 24 hour gym.
5:00 PM ET. The former Nia Jax is already teasing she'll do Renee Paquette's podcast.
The final numbers for Rampage are 431,000 viewers and a 0.18 demo in 18-49, the lowest viewership and second lowest demo ever for the show. The previous show did 556,000 and a 0.22. (Wrestlenomics)
SmackDown did 2.149 million viewers, the highest number since Oct. 22nd, up from 1.988 million the week before. The 18-49 demo was 0.57, also up from 0.52. (Wrestlenomics)


text:
Tigers Lock-up Verlander through 2014
The Associated Press is reporting that the Tigers have signed Justin Verlander to a five year $80 million contract. Without the contract, Verlander would have become a free agent after the the 2011 season. So, this contract takes him through his final two arbitration years and three years beyond that.
I am usually wary of pitchers being signed up long term because they are such a big injury risks. However, Verlander is the type of pitcher where you don't mind seeing a team take a risk. Last year, the 26 year old right-hander emerged as the ace of the staff leading the majors in both innings (240) and strikeouts (269). He also finished sixth in the league with a 3.45 ERA and was third in K/BB ratio (4.27).
Some have expressed concern about his 840 innings at age 26 and the fact that his 3,937 pitches were 300 more than any pitcher in the majors last year. However, he experienced no loss of velocity or command over the course of the season and has never had a serious injury. By most accounts, he also has a clean delivery which should help protect him from injuries.
The other good thing is that he'll only be 31 in 2014 which means the contract covers his prime years. So, while a pitcher's contract is never a safe one, this one is a reasonable deal. It's a move I think the Tigers had to make if they have aspirations of being a perennial contender over the next several years.
Labels: transactions
Kathleen February 03, 2010
The key to Verlander's continued success is how much he has to throw this year. Every study shows that a pitcher who is worked as hard as he was TWO years in a row suffers very high probability of injury and ineffectiveness in the third. So Leyland should NOT work him 125 pitches every game again this year. Perhaps a deeper bullpen will help.
Good thoughts in the story Lee, and also by what Kathleen said about the high pitch count and total pitches. Verlander is a horse and is very strong through the trunk and legs, with a fluid delivery. Just the same, with some good bullpen depth, it would behoove Leyland to keep the 125 and more pitched games to a minimum. Ron KC
Damon Among Best Baserunners in 2009
Busy Schedule
Casey Fien Removed from Roster
Internet Radio Interview
Tigers sign Damon to One Year Deal
SIERA makes Verlander, Scherzer Look Good
Johnny Damon Rumors Heating Up
Damon would Address Major Tigers Flaw


Reporting Technical Problems | Gurneys Seeds & Nursery Co.
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Anthony joined 3e Consulting Engineers in October 2014 and became a Director in September 2015. As a Chartered Engineer with over 20 years engineering experience Anthony has developed a good commercial understanding of the construction industry.
He has experience in delivering projects of various sizes from small classroom extensions through to large retail and leisure facilities, and has worked with a variety of different public and private clients including Nestlé, Asda, BUPA, Wakefield MBC, University of Leeds, Outwood Grange Academies Trust and Transport for Greater Manchester.
Anthony has detailed knowledge of working to tight programmes whilst helping to ensuring that facilities can remain in use during the construction period with little disrupton as possible.


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If you haven't seen it already a new A0 large scale poster printer was purchased and installed in the Park Library reception area in November. If you have any group work to do and would like to produce some good quality posters then why not try the new printer.
It is connected to any of the PCs or Macs in the library reception area. If you would like to use it ask library staff at the service desk for more information.
Have your say on the future of the University Library and enter a prize draw to win a Kindle (better odds than the lottery).
We are holding student Focus Groups on the following dates to gather feedback on our library services. You are all very welcome to come along to come along and have your say – this is your library service and your opinion really matters. The Park session below is on the 2nd May.
Please email marketresearch@glos.ac.uk to secure a place.
There will be cake and juice!
ACM journals database – now available off-campus!!!!
The popular full text computing journals database ACM Digital Library is now available both on and off-campus. This should help improve access to key journals online. Rather than having to use computers in the library or labs you can access titles in the comfort of your own home…..
Access through the Resources – Online Databases link from the Library homepage.
Library – 'Like us on Facebook' and New Books!!!!!!
Just a reminder that the Library has its own Facebook page; 'Like us' to be kept in the loop about all our new services and activities: https://www.facebook.com/UniversityOfGloucestershireLibraries.


Stay at Homewood Suites by Hilton Bel Air during your extended stay in Bel Air, MD. This modern hotel features all the comforts of home and conveniences of the office. Our suites include a full kitchen, hot full breakfast daily, evening social Monday-Thursday, business center and internet access.
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Enjoy our onsite fitness center or take a dip in the indoor pool at Homewood Suites Bel Air.


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text:
The Corps Berlin is a fraternity (Studentenverbindung) in Berlin, Germany, founded on February 9, 2009 with roots dating back to December 2, 1859. It is one of 162 German Student Corps in Germany, Austria, Switzerland, Belgium, Latvia and Hungary today. The Corps is a member of the Weinheimer Senioren-Convent (WSC), the second oldest federation of classical European fraternal corporations, with roots dating back to the 15th century and fraternities founded in several European countries.

Membership in the fraternity is open to honorable men studying at one of Berlin's universities and is based exclusively on personality, good moral standing, and strength of character. Members of the Corps Berlin value and engage in the tradition of academic fencing as a way to sharpen and prove their character under pressure. Continuing a practice dating back into the 1700s, Corps Berlin's members wear the traditional couleur, colored stripes, in green-white-black. The fraternity teaches and expects tolerance from its members, stemming from diverse ethnic, national, religious and political backgrounds.

Fundamentals and principles
Like all German Student Corps, Corps Berlin expects tolerance from its members in political, scientific and religious affairs. Members are encouraged to have their own point of view about the world and be able to argue it, but Corps Berlin as an entity always remains neutral. This neutrality is a fundamental pillar of all Corps and differentiates them from fraternities who require a certain political or religious affinity. The fraternity encourages freshly admitted (pledging "fox") members with diverse ethnic, national, religious and political backgrounds to prove themselves as valuable Corps brothers, purely on the basis of personal character and merit, before becoming eligible to be fully incorporated (Rezeption). The fraternity has about 220 members of all ages (including alumni) coming from or currently residing in Europe, Asia, the Americas and Africa. Every full member is a member for life.

Members of the Corps Berlin value and practice the tradition of engagements in academic fencing, or "Mensur" in German, with members of other old-school fraternities. Academic fencing, originating in the German school of fencing, is understood as a way to exercise good judgement and prove character, allowing participants to show determination by standing their ground under pressure, while enhancing the bonds between the Corps brothers at the same time. Mark Twain described one of these fencing duels/challenges in his day and age; his description is remarkably similar to current practices. Corps Berlin's members identify themselves wearing the traditional couleur, colored stripes, as well as caps and/or other specific garments at official occasions. This tradition, known as "wearing colors" (German: Farben tragen), provides means to recognize members of other fraternities and, likewise, identification for the Corps brothers with each other and their traditions.

Activity and responsibility are two fundamental expectations for fraternity members. With the goal to achieve members who are prepared to become active leaders in society, every Corps brother is expected to hold a leadership position at least once for a term ("Semester") while a student. Members are further encouraged to organize internal and open fraternity events that draw attention from other fraternities and guests from industry, academia, politics and other active societies. Allocating the necessary resources appropriately and living up to set expectations teaches responsibility. All members must show active participation in the regular fraternity Convents, providing the foundation for the fraternity's members to meet and discuss past, present and future developments. Decisions are cast in a democratic manner, sometimes after intense debates. Participation at such Convents teaches a better understanding of proper argumentation, group dynamics and critical analysis of other members' views, plans and arguments, thereby preparing its participants to become active members of society. Similarly, every member must finish his higher educational degree with good academic standing in order to advance to the status of Alter Herr (alumnus).

Long-term guidance is expected from and provided by said Alte Herren, who often remain very engaged and well connected with the fraternity. Every year at the end of May, student and alumni members of all German Student Corps meet in one of two cities (Weinheim and Bad Kösen) for three days to refresh their bonds with their fraternity and friends from the entire Corps network (WSC/KSCV). In addition to these international meetings once a year, alumni join the student members for multiple local meetings, lasting an evening or a weekend. These regular meetings result in strong bonds spanning the generations within the fraternity.

History

Foundation

The fraternity was founded by joining three Corps on February 9, 2009: Corps Cheruscia with its original founding date December 2, 1859; Corps Rheno-Guestphalia with its original founding date February 4, 1870; and Corps Teutonia with its original founding date July 1, 1870.

Today
The fraternity has official relationships with the Corps Altsachsen Dresden, Corps Saxo-Thuringia München in Munich and Corps Hannoverania in Hanover, forming the Blaues Kartell of four fraternities throughout Germany that understand the cartel as one large fraternity in four different cities.

Relationships with other fraternities
Corps Berlin is a member of the "Blaues Kartell", a circle of four German Student Corps that understand the union as "one fraternity spanning four cities" (Berlin, Dresden, Hanover, and Munich).
In chronological order. Links to the German Wikipedia are in process of being translated and currently indicated with "ge".
 Corps Saxo-Thuringia München in Munich
 Corps Hannoverania Hannover
 Corps Altsachsen Dresden

Literature

 Lees Knowles: A day with corps-students in Germany
Mark Twain describes his encounters with German corps students in chapters IV to VII of his travelogue A Tramp Abroad.
Mark Twain describes specifically the fencing scene in A Tramp Abroad.
Secondary web source of Mark Twain's descriptions of his encounters with German corps students in chapters IV to VII of his travelogue A Tramp Abroad.

 Paulgerhard Gladen: Die Kösener und Weinheimer Corps. Ihre Darstellung in Einzelchroniken. WJK-Verlag, Hilden 2007, , S. 91–92.
 Hans Schüler: Weinheimer S.C.-Chronik, Darmstadt 1927, S. 434-454
 Michael Doeberl u. a. (Hrsg.): Das akademische Deutschland, Band 2: Die deutschen Hochschulen und ihre akademischen Bürger, Berlin 1931, S. 735
 Rolf-Joachim Baum: "Wir wollen Männer, wir wollen Taten!" – Deutsche Corpsstudenten 1848 bis heute. Berlin 1998, S. 7–12.
 Paulgerhard Gladen: Geschichte der studentischen Korporationsverbände, Band 1, S. 53, Würzburg 1981

References

External links

Weinheimer Senioren-Convent
1859 establishments in Germany
Tourist attractions in Berlin
Student societies in Germany
Academic culture
Swordsmanship
Philosophy of education
Organizations established in 1859


text:
Large Dutch Ovens
Dutch ovens do it all. But which pot makes "it all" easiest?
More on the Best Dutch Ovens
We also tested and recommend the small and medium versions of these Dutch ovens.
Is there anything you can't do with a Dutch oven? We use these large, heavy-duty pots for boiling, searing, frying, braising, and baking food and for sous vide cooking. We turn them into smokers, steamers, coolers, and panini presses. They might just be the busiest pots in our kitchen.
Our longtime favorite, the Le Creuset 7¼ Quart Round Dutch Oven, works perfectly, but at $367.99, it costs a pretty penny. At the other end of the spectrum is a classic cast-iron model that costs seven times less—and there's a pot in every price bracket in between. So how much do you need to spend to get a Dutch oven that will last for years, is capable of cooking everything you throw at it, and makes said cooking as easy as possible?
To find out, we surveyed the options and chose 11 widely available Dutch ovens priced from $54.31 to $367.99, including the Le Creuset and our top inexpensive option, the Cuisinart Chef's Classic Enameled Cast Iron Covered Casserole ($83.70). Each held at least 6.5 quarts, a capacity that works well for all our recipes. We put them through a litany of tests, rating each pot on the quality of its food, how easy it was to use and clean, and how durable it was. At the end of testing—after a whole lot of cooking and eating—we concluded that all of these pots are capable of making good food, but some were much easier to use. Here's what mattered.
Material Differences
Lighter, thinner Dutch ovens tend to scorch food because the heat zips right through them. With that in mind, we focused on heavier ceramic and cast-iron models. The only ceramic model we tested weighed 9.75 pounds; the cast-iron pots ranged from 13.7 to 18.15 pounds. We had hoped that the ceramic might provide a lighter alternative to cast iron, but it proved too fragile for such a workhorse pot. We were nervous handling it, and the lid cracked when we firmly set it on the base from a mere 2 inches above. This left us with the cast-iron models and our next question: coated or uncoated?
All but one of the cast-iron pots were coated with enamel, a type of glass; we tested one uncoated Dutch oven from Lodge, the maker of our winning traditional cast-iron skillet. Like the skillet, it arrived fully seasoned but required extra care, as it has to be dried and oiled immediately after washing. This isn't particularly hard, but it was more work.
In the past, when we tested the uncoated Lodge Dutch oven, we found that food cooked in it sometimes tasted metallic. This time around, though, we were pleasantly surprised. Tasters didn't notice any off-flavors in the food, even after we simmered an acidic tomato sauce (acid can strip the pot's seasoning) and then cooked fairly neutral white rice and French fries. A representative from Lodge said that the company is constantly improving its equipment, so newer pots may have more-durable seasoning.
Seeing the Light: Interior Color Is Key
Like the uncoated model, four of the enameled Dutch ovens had dark interiors. This made it difficult to monitor browning and to see how dark our fond got as we seared beef. It also made it more challenging to use our remote thermometer, which we often clip onto our Dutch oven to track the temperature of oil while frying. Dark interiors prevented us from easily spotting the tip of the probe to ensure that it wasn't touching the pot, which can cause it to give a false reading. Overall, lighter interiors provided better visibility and were easier to cook in.
Broader Pots Are More Efficient
Some pots were tall and narrow; others were short and broad. We preferred those with generous cooking surfaces—at least 9 inches across. More usable surface area meant we could work faster, particularly when browning in batches. We also preferred low, straight sides, as tall or curved sides tended to partially block our view into the pot.
A Helping Handle
Because we prefer heavier Dutch ovens, handles are hugely important, particularly when the pot is weighed down with stew or quarts of frying oil. There were two handle styles in our lineup: flat and looped. The flat handles stuck out from the sides of the pot like tabs, the looped ones like semicircles. We much preferred the latter style because the loops allowed for a fuller, more secure grip; bigger loops were even better, especially when oven mitts were in the mix.
A Pot for Every Kitchen
In the end, we're able to recommend all but two models; however, the Le Creuset 7¼ Quart Round Dutch Oven ($367.99) is still the best. At 13.7 pounds, it was the lightest of the cast-iron models, yet it was still heavy enough to conduct heat well. With a broad, light-colored cooking surface; low, straight sides; and large looped handles, it was also exceptionally easy to use.
For a less expensive option, we again recommend the Cuisinart Chef's Classic Enameled Cast Iron Covered Casserole ($83.70) as our Best Buy. It's shaped very similarly to the Le Creuset, with a broad cooking surface and low, straight sides for maximum efficiency and easy maneuvering. It's 3 pounds heavier than our winner and has smaller handles, but it costs almost $300.00 less. Like most of the models in our lineup, both of these pots come with a limited lifetime warranty. But the Le Creuset held up better to the kind of everyday wear and tear not covered by the warranty; the rim and lid of the Cuisinart model chipped cosmetically during our durability tests, while our winner emerged from testing looking as good as new.
We tested 11 Dutch ovens, priced from $54.31 to $367.99: nine made from enamel-coated cast iron, one from uncoated cast iron, and another from ceramic. We used each to boil water, cook rice, braise beef, make French fries, bake bread, sear meatballs, and simmer the meatballs in tomato sauce. To test durability, we scrubbed each pot clean with an abrasive sponge 10 times, whacked the rim of each pot with a metal spoon 50 times, and firmly settled each lid onto the base 25 times. We measured and weighed each pot (total weight includes lid). Prices are what we paid online, and the pots are listed in order of preference.
Rating Criteria
Cooking: We boiled water, cooked rice, braised beef, fried French fries, seared meatballs, simmered sauce, and baked bread. All the pots we tested were able to make properly cooked food.
Ease of Use: We evaluated the pots on how easy they were to cook in, clean, and move around. Medium-weight pots with large, comfortable handles; broad, light-colored cooking surfaces; smooth lids; and low, straight sides rated highest.
Durability: We beat up the pots to make sure they could withstand years of heavy use. Those that didn't chip or crack rated highest.


text:
Pharmaco Vigilance
focus / Thursday, June 3, 2021
The hypoglycemia of little Osvaldo
Osvaldo is 14 months old and suffers from long QT syndrome, treated since the first month of life with nadolol 10 mg/day.
One morning his parents found him sweating and immobile in bed, with hypotonic arms and legs. He was immediately taken to the emergency room, where he appeared extremely pale, with reduced consciousness (Glasgow Coma Scale: 9), ketonuria, hypoglycemia (11 mg/dl) and metabolic acidosis with normal lactates.
An immediate administration of glucose is made, thanks to which hypoglycemia and ketonuria are promptly resolved.
The numerous investigations Osvaldo underwent excluded metabolic, endocrine, neurological disorders and infections as possible causes of hypoglycemia. It is therefore hypothesized that the hypoglycemic episode is related to the administration of nadolol, so the drug is suspended and replaced with propranolol, which is well tolerated, without further hypoglycemic episodes.1
Hypoglycemia and beta-blockers: new evidence from the real world and the scientific literature
Hypoglycemia is a known adverse reaction to beta-blockers. The hypothesized mechanism includes direct inhibition of hepatic gluconeogenesis and pancreatic glucagon release, probably mediated by antagonism on β-2 adrenergic receptors.2,3,4,5,6
Infants and children are at higher risk for hypoglycemia because of increased glucose utilization in fasting states and lower glycogen stores.7
To date, it remains unclear which drugs in this class are most frequently associated with the induction of hypoglycemia and whether their pharmacological characteristics play a potential role in the induction of this adverse reaction. With the aim of quantifying the association between exposure to different beta-blockers and the risk of hypoglycemia reporting in pediatric patients, we performed a nested case-control analysis of suspected adverse reaction reports notified in the US FAERS spontaneous reporting database.
We, therefore, extracted reports entered from 2000 to 2019 in which at least one beta-blocker was involved. Of the 117,963 cases identified, after manually excluding reports with incomplete information and duplicates, 83,954 reports were selected; among these, 1,465 reported hypoglycemia, of which more than 20% involved the pediatric population.
For each individual beta-blocker, the Reporting Odds Ratio (ROR) and its 95% confidence interval (IC95) were estimated. The ROR, based on what was spontaneously reported during pharmacovigilance activities, measures the risk of experiencing an adverse drug reaction. It is therefore a parameter capable of quantifying the association between the use of a drug in daily clinical practice and the increase (statistically significant or not) of the reporting activity. If the ROR is statistically significant, it means that the number of reports of adverse reactions involving that drug exceeds what we would have expected on the basis of previous knowledge; this concept of disproportionality is an indication of a possible "signal" of safety.
Statistically significant RORs were found for nadolol (ROR: 6.98, IC95 5.40 to 9.03), followed by celiprolol (ROR: 2.35, IC95 1.35 to 4.10), propranolol (ROR: 2.14, IC95 1.87 to 2.46), and bisoprolol (ROR: 1.42, IC95 1.25 to 1.61).
After removal of reports with other suspected drugs besides beta-blockers or concomitant drugs for which the hypoglycemic effect is known, nadolol and propranolol not only maintained statistical significance but the disproportionate signal increased, albeit with wide confidence intervals, 14.95 (IC95 10.62 to 21.06) and 5.67 (IC95 4.53 to 7.11), respectively.
To investigate which pharmacodynamic and pharmacokinetic parameters of beta-blockers are potentially associated with the induction of hypoglycemia, a novel statistical approach was employed by coupling data from pharmacovigilance analyses with the different selectivity for β-1 receptors and the different half-life of each drug belonging to this class.
Because pediatric reports were found to be significantly statistically more associated with hypoglycemia than adults (p=0.0001), only cases and noncases that emerged in children were selected and paired 1:1 for age, sex, and concomitant hypoglycemic drugs.
On this selected cohort, the possible association between the two pharmacological parameters and the risk of hypoglycemia reporting was estimated by logistic regression in the form of an adjusted Odds Ratio (aOR). It was found that a half-life longer than 10 hours was positively associated with the risk of hypoglycemia reporting (aOR: 2.23). In contrast, selectivity for β-1 was found to be associated with a decreased risk of hypoglycemia.
Finally, a systematic review of the literature was conducted to compare evidence from a clinical practice setting with data provided by clinical trials. Because of the high heterogeneity of the studies, a wide variation in the frequency of occurrence of hypoglycemia (0.5% to 10%) was observed, with the incidence rate decreasing as the sample size increased.
Thus, the FAERS analysis suggests that nadolol is associated with a 6-fold increased risk of hypoglycemia reporting compared with other beta-blockers. In this regard, no data exist in the literature: to date, this is the first analysis to demonstrate hypoglycemia induced by this class of drugs in the pediatric population, coupling pharmacovigilance data with characterization of the pharmacokinetic profile of individual beta-blockers.
The results of our study support the hypothesis that nonselective beta-blockers are more likely to induce hypoglycemia,8 and the risk of signaling was also found to be increased as the half-life of the drug increased. Despite the inherent limitations of this type of analysis, such as the inability to estimate absolute risk because of the lack of total prescription data, this study provides useful insights to support clinicians in choosing the most appropriate drug.9
Further large-scale prospective observational studies are needed to confirm these findings.
Greta Guarnieri1, Michele Gringeri1, Giulia Mosini1, Gianluca Cammarata1, Vera Battini1, Francesco Bergamaschi2, Marta Fumagalli2, Valentina Fabiano2 Carla Carnovale1, Sonia Radice1
Pharmacovigilance Service, UO Clinical Pharmacology, Department of Biomedical and Clinical Sciences, ASST-Fatebenefratelli-Sacco, University of Milan
Pediatric Clinic, Children's Hospital - V. Buzzi, Department of Biomedical and Clinical Sciences, ASST-Fatebenefratelli-Sacco, University of Milan
Bergamaschi F, Fumagalli M, et al. Severe hypoglycemia in children treated with nadolol: a case report and FDA adverse event reporting system (FAERS) database analysis. Int J Clin Pharmacol Ther 2021;59:333-40. CDI
Bain A. Beta-blocker use in cardiovascular disease. Br J Card Nurs 2018;13(10).
Vishal K, Aregullin O, et al. Trends in the off-label use of beta-blockers in pediatric patients. Pediatr Int 2019;61:1071-80. CDI
Vue M, Setter S. Drug-induced glucose alterations Part 1; Drug-induced hypoglycemia. Diabetes Spectr 2011;24:171-7. NS
Pépin V, Gagné N, et al. Recurrent hypoglycaemia in a toddler on β-blocker therapy. Cardiol Young 2018;28:511-3. CDI
Sherwin R, Saccà L. Effect of epinephrine on glucose metabolism in humans: contribution of the liver. Am J Physiol 1984;247:E157-65.
Holland K, Frieden I, et al. Hypoglycemia in children taking propranolol for the treatment of infantile hemangioma. Arch Dermatol 2010;146:775-8.
Ahrén B. Autonomic regulation of islet hormone secretion - implications for health and disease. Diabetologia 2000;43:393-410. CDI
Carnovale C, Gringeri M, et al. Beta-blocker-associated hypoglycaemia: New insights from a real-world pharmacovigilance study. Br J Clin Pharmacol 2021;DOI:10.1111/bcp.14754. CDI
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A syndrome known in literature, but underestimated and underdiagnosedAllergic angina, or Kounis...
Luisa's dark urine
Hepatic toxicity of macrolidesLiver damage caused by ingesting a drug is denoted by the acronym...
Camilla has one bra size up
A possible explanationLiterature and pre-marketing phase do not report any cases of mammary...
Matteo's sudden jaundice
Intrahepatic bile ducts breakageChlorpromazine damages to biliary tree have been described in the...
Paola's unexpected madness
Different pathogenic hypothesisPrucalopride has been commercialized in Europe since 2009 as...
Camilla was disoriented in space
A possible explanationIfosfamide is an alkylating agent1 whose toxic manifestations include: myelo-...
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