text:
Driving drug resistance out of fungi
New gene drive targeting a fungal pathogen enables identification of virulence regulators and potential future combination therapies
(BOSTON) — Candida albicans is a notorious human fungal pathogen that causes thrush and serious systemic infections. Opportunistic C. albicans fungi, which often live inconspicuously in the normal flora of human skin and gut, can switch from their harmless stealth mode to become aggressive pathogens, especially in people whose immune systems are already compromised by pre-existing diseases or harsh drug therapies. They can also form biofilms on medical devices, such as catheters and stents in the human body, leading to infections and sometimes death. The threat posed by both free and biofilm-bound forms of the pathogen is constantly growing, as virulent C. albicans strains are becoming increasingly resistant to the few drugs that are available to treat them.
This image shows multicolored diploid Candida albicans growing on an agar plate with red-colored colonies indicating that two copies of a marker gene have been effectively deleted by the gene drive. Credit: Wyss Institute at Harvard University
Microbiologists are facing tremendous difficulties in their quest to fight C. albicans' drug resistance and biofilm formation. Each C. albicans microbe is a "diploid" organism, as it usually contains two copies of its entire genome and of all the genes encoded within. However, to understand the role that a specific gene plays, researchers need to be able to delete both copies at the same time, allowing them to observe the effects of the gene's total absence, which has been a difficult challenge in C. albicans. In addition, genes often play very similar and sometimes redundant roles in many processes, including drug resistance and biofilm formation, meaning that more than one gene needs to be deleted to identify those genes whose functions are linked.
To approach the gene deletion challenge in C. albicans, a collaborative team led by James Collins and George Church, two Core Faculty members at Harvard's Wyss Institute for Biologically Inspired Engineering, have developed a CRISPR-Cas9-based "gene drive" platform to create diploid strains of the pathogen in which both gene copies could be efficiently deleted. The technique may lead the way toward a better understanding of drug resistance and biofilm-forming mechanisms, and through future research, it could help pinpoint new drug targets and combination therapies. The study is published in Nature Microbiology.
The team took advantage of a recently discovered very rare "haploid" form of C. albicans which, like those of other fungi, only contains one set of chromosomes with one copy of each gene, but they can be mated to easily create the diploid form. "We used haploid C. albicans strains and replaced genes that we wanted to eliminate with a 'gene drive' that we previously developed and adjusted to the specific biology of C. albicans. After mating, these 'selfish genetic elements' proceed to replace the normal copy of the gene in the diploid fungi," said Church, Ph.D., who is a Professor of Genetics at Harvard Medical School and of Health Sciences and Technology at Harvard and MIT. "The approach worked so efficiently that it enabled us to even delete pairs of different genes simultaneously with higher throughput and to explore whether their functions are related."
The new gene drive approach is based on the CRISPR-Cas9 system, in which a DNA-cutting Cas9 enzyme is targeted to two regions that flank a gene in haploid C. albicans fungi by two so-called guide RNAs (gRNAs). After the targeted gene sequence has been cut out, an engineered gene drive cassette expressing all Cas9 and gRNA components is inserted in its place. When two haploid fungi are mated to form diploid offspring, the gene drive will also substitute the gene's counterpart in the other chromosome, effectively deleting the original version from the organism entirely.
By applying their gene deletion approach, the team was able to identify combinations of genes that act synergistically in defying certain drugs, or in triggering biofilm formation. "For example, deleting either the two efflux pump-encoding genes CDR1 and CDR2, or TPO3 and CDR2 together, rendered C. albicans highly sensitive to fluconazole and other antifungal drugs, suggesting that targeting two mechanisms at the same time could help overcome drug resistance," said Rebecca Shapiro, Ph.D., a Postdoctoral Fellow in Collins' team. Shapiro teamed up with Alejandro Chavez, Ph.D., as first co-authors on the publication. Chavez is a former Postdoctoral Fellow who worked with Church and Collins; he is now an Assistant Professor at New York's Columbia University. "In biofilm formation assays, we also found that loss of the ALS3 adhesion factor gene synergizes with the loss of several other adhesion factor genes, which makes it a highly interconnected hub of biofilm adhesion and an interesting candidate to further explore."
The study offers new inroads into understanding the difficult territory of C. albicans pathogenesis and drug resistance. "We can now get a much better handle on how genetic networks that underlie the virulence of C. albicans are organized, see how they respond to specific environmental and drug perturbations, and thereby uncover new vulnerabilities, that in the future may lead to new drug targets and combination therapies," said Collins, Ph.D., who also is the Termeer Professor of Medical Engineering & Science at Massachusetts Institute of Technology (MIT) and a Professor of Biological Engineering at MIT. "Moreover, our gene drive array platform can be a blueprint for similar approaches in other fungal pathogens, such as the newly emerging Candida auris, which is highly drug resistant and has already been marked as a threat by the Centers for Disease Control and Prevention."
"This symbiotic collaboration between faculty leaders of two of the Wyss Institute's Enabling Technology Platforms, Jim Collins and George Church, led to important new insights into the the biology of this infectious fungal pathogen and how it develops resistance, in addition to opening an entirely new path for design of more effective antifungal therapies," said Wyss Institute Founding Director Donald Ingber, M.D., Ph.D., who is also the Judah Folkman Professor of Vascular Biology at HMS and the Vascular Biology Program at Boston Children's Hospital, as well as Professor of Bioengineering at SEAS.
Additional authors on the study are Yue Wang, Ph.D., Professor and Research Director at the Institute of Molecular and Cell Biology in Singapore, his Postdoctoral Fellow Guisheng Zeng, Ph.D., and Research Technician Xiaoli Xu; Natalia Kirienko, Assistant Professor at Rice University, and her Research Technician Alexey Revtovich; as well as past and present members of Collins' team, including Postdoctoral Fellow Caroline Porter, Ph.D., now a Computational Scientist at the Broad Institute, and Research Technician Meagan Hamblin; and of Church's team, including Postdoctoral Fellow Christian Kaas, Ph.D., now a Senior Research Scientist at Novo Nordisk, and James DiCarlo, Ph.D., a former Graduate Student with Church. The work was funded by grants from the National Cancer Institute, the US National Institutes of Health National Human Genome Research Institute, the Wyss Institute for Biologically Inspired Engineering at Harvard University, and the Paul G. Allen Frontiers Group.
PUBLICATION - Nature Microbiology: A CRISPR–Cas9-based gene drive platform for genetic interaction analysis in Candida albicans
James J. Collins
Living Cellular Devices
Harvard Medical School (http://hms.harvard.edu) has more than 7,500 full–time faculty working in 11 academic departments located at the School's Boston campus or in one of 47 hospital–based clinical departments at 16 Harvard–affiliated teaching hospitals and research institutes. Those affiliates include Beth Israel Deaconess Medical Center, Brigham and Women's Hospital, Cambridge Health Alliance, Boston Children's Hospital, Dana–Farber Cancer Institute, Harvard Pilgrim Health Care, Hebrew Senior Life, Joslin Diabetes Center, Judge Baker Children's Center, Massachusetts Eye and Ear Infirmary, Massachusetts General Hospital, McLean Hospital, Mount Auburn Hospital, Schepens Eye Research Institute, Spaulding Rehabilitation Hospital and VA Boston Healthcare System.
Press Release Keeping the genetic code clean
Press Release Profiling the genome hundreds of variations at a time
Press Release Harvard's Wyss Institute welcomes Massachusetts Institute of Technology as a new collaborating institution


text:
Graeme MacKay's Editorial Cartoon Archive
Young Doug Ford
Friday August 11, 2017
August 10, 2017 by Graeme MacKay
Editorial Cartoon by Graeme MacKay, The Hamilton Spectator – Friday August 11, 2017
Canada's Army Builds Tent Camp For Haitian Asylum-Seekers Arriving From U.S.
Featuring a Fire and Fury gallery of Donald Trump cartoons
The Canadian military is building a temporary shelter near the border with the United States, to accommodate hundreds of asylum-seekers crossing illegally from the U.S. into Quebec.
Most of those arrivals are Haitians who were admitted to the U.S. after the earthquake in 2010, and whose future legal status in America is unclear.
Dan Karpenchuk, reporting for NPR, says the Canadian service members are only building the camp, not remaining afterward to staff it.
"The camp will hold as many as 500 seekers, about the number of asylum-seekers waiting to be processed," Karpenchuk reports. "The soldiers will also set up lighting [and] heating, and install flooring. They will not have security roles."
The CBC reports that currently, the Royal Canadian Mounted Police have a tent set up at the border to handle processing — but there are no beds. People spend two to three days waiting on benches and chairs.
The soldiers, at the request of Public Safety Canada, are assembling a camp at a nearby "converted private campsite," the CBC reports.
"Setting up tents, this is something obviously we're quite familiar with, we're pretty good at doing this," Maj. Yves Desbiens, the spokesperson on the ground for the Canadian Armed Forces, told the Canadian broadcaster. "But in terms of these capacities, this is not something we do often."
The tent camp on the border is just the first stop for asylum-seekers.
"After they're processed, the asylum-seekers will be bused to Montreal, where they will be put up in other temporary accommodation, including the Olympic Stadium, a former convent and now a facility at one of the city's hospitals," Karpenchuk says.
As we reported last week, Montreal's Olympic Stadium has just recently been pressed into service to house asylum-seekers, after normal facilities were overwhelmed. But it's only a temporary option, since the stadium won't be available during upcoming events.
The surge has, by all accounts, been dramatic. Last week, a spokesperson for the provincial government organization that helps asylum-seekers told the CBC that the group helped about 180 people last July — and that more than 1,000 people crossed the border this July.
Immigration Canada told the CBC on Wednesday that crossings at one point along the border have quadrupled in just the past two weeks. (Source: NPR)
Posted in: Canada, USA Tagged: Canada, diplomacy, Donald Trump, fire, Fire and Fury, Haiti, Haitian, Immigration, map, refugees, USA
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Gibraltar's 5606EX Concert Height Snare Stand utilizes all professional features in a low mass double-braced stand. The double-braced tripod with cast height assembly and Gibraltar's round rubber feet provide stability without large profile. These stands also feature a gearless basket tilter.


I have been selling Scouting memorabilia on eBay for almost twenty years. So the idea of having a brick and mortar store location for Scouting collectibles might sound a little backwards. However, for several years now I've run with a strategy to have an antique mall booth location where I can sell 7 days/week to anybody while I'm back in the office throwing stuff up on the Internet.
Today my Santeeswapper Store booth is my clearance center. Having accumulated mountains of uniforms, books, and other hard to ship items this booth at The Sleepy Poet is going to help me move inventory while giving collectors, Scouters and parents a bargain. You won't find any "antique mall prices" in my booth. I've got 50+ year old handbooks for $5 and many old uniforms for $10. Believe it or not I have more of this kind of stuff in a storage unit so I discovered the only way to move it quickly was to give people a price that they couldn't find anywhere else. Please follow me on Facebook or find me on Google+ for more updates.


Today's picture is another one along Kebler Pass Road. This one was taken from the road itself – it winds itself right around this peak, which I'm fairly sure is called Marcellina Mountain.
I've realized over the past few days that I'm not going to be able to keep this one-picture-a-day-from-my-Colorado-trip thing going as long as I hoped to, because a lot of my pictures just plain didn't turn out. Multiple equipment malfunctions, it turns out. Specifically, just about every picture I took with my telephoto is complete garbage. Like, not even close to in focus, stuff like that. I think a lot of it has to do with the new polarizer I got for that lens, but I can't yet put my finger quite on why that would have made such a drastic difference. I mean, it's not totally unexpected – since it had been so long since I had really been out taking pictures, I figure there'd be hundreds of little things that I'd just be forgetting about (forgetting to compose pictures in certain ways, forgetting about little tips and tricks to make things come out better, etc), but it's still superbly frustrating, seeing pictures that I was *sure* I had nailed turning out not quite right, or in many cases, not turning out at all. Sad. Very sad. Sigh. Oh well, I think I've got at least a couple more in me, we'll see.
Notes: Canon EOS Rebel T1i, Tamron 17-50mm f/2.8 lens. 1/200s, f/5.6, ISO 200. Focal length: 42mm.


text:
Holy One Thousand Martyrs
Holy Martyr Mardonios
Holy Martyr Stratonikos
Translation of the Relics of Saint Donatos of Euro...
Synaxarion of the Holy Martyr Goudelia of Persia
Holy Martyr Petronia
Holy Martyrs Tryphon, Trophimos and Dorymedon
Holy Hieromartyr Alkison, Bishop of Nicopolis (+ 5...
Saint Herodion, Founder of Iloezersk Monastery (+ ...
Saints Euthymius and Chariton, Abbots of Syanzhema...
Holy Martyr Alexander and the Thirty Martyrs With ...
Holy Martyrs Eustathios the Roman and Kallinikos
Holy New Hieromartyr Anthimos the Iberian, Metropo...
Saint Sabbatius of Solovki the Wonderworker (+ 143...
Holy Apostles Mark, Aristarchus and Zenon of the S...
Holy Marytrs Philemon the Bishop and Fortunianus
Holy Fifteen Martyrs Who Drowned at Sea
Holy Martyr Gaiana
Saint Ephraim of Perekop the Wonderworker (+ 1492)...
Holy Martyr Chera
When Fr. Benedict Petrakis Resurrected his Dead Be...
Saint Euphrosyne of Suzdal (+ 1250)
Saint Arsenius the Great, Catholicos of Georgia (+...
Saint Sergius of Radonezh Resource Page
Holy Martyrs Paul and Tatta and their children Sab...
Monastery of the Panagia of Filerimos in Rhodes
Holy Venerable Martyr Galaction of Vologda (+ 1612...
Saint Nicander of Pskov (+ 1581)
Saint Dorothy of Kashin (+ 1629)
Encomium on the Conception of Saint John the Bapti...
Conception of Saint John the Baptist Resource Page...
A Weeping Icon of the Holy Mandylion in Patmos
Holy Martyrs Isaac and Martin
Holy Martyrs Eusebius, Nestabus and Zeno who were ...
Holy Six Martyrs, who were Armor-Bearers of Empero...
Holy Martyr Eusebius
Holy Prince Oleg of Briansk, who was Tonsured with...
Holy Martyrs Michael the Prince of Chernigov and T...
Holy Venerable Martyr John the Egyptian and the Fo...
Holy Martyrs Artemidoros and Thallos
Oxyrhynchus, the Egyptan City Once Full of Saints
Holy Martyrs Bidzina, Shalva and Elizbar, Princes ...
Holy Martyr Kastor
Holy Martyrs Sophia and Irene of Egypt
Holy Hieromartyrs Herakleides and Myron, Bishops o...
Holy Martyrs Haralambos and Panteleon with their C...
Holy Martyrs Maximos, Theodotos, Hesychios and Ask...
Gospel Commentary for the Sunday After the Holy Cr...
Origins of the Feast of the Exaltation of the Holy...
Why Every Christian Should Wear A Cross
Holy Martyr Valerianos the Infant
Holy Martyr Theokles
Hagia Sophia To Remain a Museum
Saint John of Prislop
The Historical Development of the Feast of the Nat...
Saint Athanasius of Serpukhov the Elder (+ 1401) a...
Saint Bassian of Tiksnensky in Vologda (+ 1624)
Holy Martyrs Macedonios, Theodoulos and Tatian of ...
Holy Martyr Okeanos
Saint Euphrosynos the Cook ... Cooking
Saint Theodora of Vasta Resource Page
Miracles of Saint Theodora of Vasta
Documentary on the Church of Saint Theodora in Vas...
Saint Paul the Obedient of the Kiev Caves
Saint Joasaph of Kubensk, Wonderworker of Vologda ...
Holy Martyr Chariton
Gospel Commentary for the Sunday Before the Holy C...
Saint Sophronios, Bishop of Akhtala in Iberia (+ 1...
Holy Martyr Artemidoros
Holy Martyr Severus
Holy Martyrs Rufus and Rufianus
Synaxarion of Saint Kassiani the Hymnographer
Saints Symeon (1476) and Amphilochius (1570) of Pa...
Saint Macarius of Optina (+ 1860)
Holy Hieromartyr Macarius of Kanev (+ 1678)
Holy New Martyr Lygeri of Chios (+ 1822)
Saint Eleutherius, Abbot of Saint Mark's Abbey in ...
Consecration of the Church of the Most Holy Theoto...
Homily on Saint Babylas of Antioch (St. John Chrys...
Saint Symeon the Wonderworker of Gareja (+ 1773)
Finding of the Sacred Relics of the Holy New Marty...
Holy Three Thousand Six Hundred and Twenty-Eight (...
Holy Martyr Sarbelos
Translation of the Relics of Saint Nektarios the W...
Saint Constantine the New, Emperor of the Romans (...
Holy Hieromartyr Aristion, Bishop of Alexandria
Holy Martyr Archontios
Holy Martyr Zenon
Gospel Commentary for the Fourteenth Sunday of Mat...
The Month of September in the Orthodox Church
Holy 1,000 Martyrs (Feast Day - September 30)
The one thousand in number regiment were decapitated,
As prize for the contest they found innumerable crowns.
The Holy One Thousand Martyrs met their end by the sword.
Labels: Early Christian Martyrs, Saints of September
St. Mardonios the Martyr (Feast Day - September 30)
Bearing the mark of your passion Mardonios,
You bear on your navel the seal of burning.
The Holy Martyr Mardonios met his end by receiving burning coals on his navel.
St. Stratonikos the Martyr (Feast Day - September 30)
Stratonikos by coming to an end through the sword,
Conquered by himself the entire demonic host.
The Holy Martyr Stratonikos met his end by the sword.
Translation of the Relics of Saint Donatos of Euroea from Venice to Paramythia
Saint Donatos reposed in 387 and was buried near a church he built and a grave he prepared in the village of Glyki of Paramythia, which is in Epirus, Greece. For security reasons due to the invasion of various barbaric tribes, the sacred relic was transferred in 604 to Kerkyra, where it was kept in Kassiopi. The refugees from Paramythia accompanying the relic, including Bishop John of Euroea, were welcomed by Bishop Alkison of Kerkyra and hosted in the Castle of Kassiopi.
Read the complete article »
Labels: Ecumenism, Orthodoxy in Italy, Relics, Saints of Mainland Greece, Saints of September
St. Goudelia the Martyr (Feast Day - September 29)
Goudelia by the sword hastened with her head,
To you Christ the head of all.
She lived during the reign of King Shapur of Persia (309-379), and because she converted many unbelieving Persians to the faith of Christ, she was apprehended by the king, and the blessed one was punished with many torments. Unable to be persuaded to sacrifice to the fire, she was put in prison. There she remained for many years, where she starved for lack of food.
Labels: Female Saints, Saints of Persia, Saints of September
Petronia bent her head to the sword,
Fixing the eyes of her soul on the divine rock.
The Holy Martyr Petronia met his end by the sword.
Labels: Early Christian Martyrs, Female Saints, Saints of September
Sumptuous nourishment was found above,
By Trophimos, Tryphon as well as Dorymedon.
We have no information about them in the synaxaria, except that their synaxis was celebrated on September 29th next to the Church of Saint Anna in the Deuteron district of Constantinople. It may be that Trophimos and Dorymedon are the same Holy Martyrs commemorated on September 19th, who were martyred in Phrygia, and Tryphon was the same Holy Martyr commemorated on February 1st, who also was martyred in Phrygia. Perhaps their shrine in Constantinople contained relics of these three Phrygian martyrs.
Holy Hieromartyr Alkison, Bishop of Nicopolis (+ 516)
St. Alkison of Nicopolis (Feast Day - September 28)
Saint Alkison was Bishop of Nicopolis (now Preveza) in Epirus from 491 to 516, and became a valiant opponent of the policy of accommodation with the Monophysites pursued by the Emperor Anastasios I (495-518) and his successors. He firmly resisted every attempt at persuading him to condone heresy and was imprisoned at Constantinople, where he died of the effects of ill-treatment, on 28 September 516.
Labels: Monophysites, Saints of Mainland Greece, Saints of September
Saint Herodion, Founder of Iloezersk Monastery (+ 1541)
St. Herodion of Iloezersk (Feast Day - September 28)
Saint Herodion of Elias Lake (Iloezersk) and Novgorod, was a disciple of Saint Cornelius of Komel (+ May 19, 1537). After the death of his mentor, he settled at Elias Lake, 20 kilometers from White Lake, and there on a peninsula he built himself a cell and established a church in honor of the Nativity of the Most Holy Theotokos, marking the beginning of the Elias Lake Ozadsk Monastery (Iloezersk Monastery).
Labels: Saints of Russia, Saints of September
Saints Euthymius and Chariton, Abbots of Syanzhema Monastery in Vologda (+ 1509)
Sts. Euthymius (Jan. 20) and Chariton (Sept. 28) of Syanzhema
Saint Euthymius and his disciple Saint Chariton lived at the River Syanzhema during the close of the fifteenth and the beginning of the sixteenth centuries. Saint Euthymius came to the Spasokamensk Monastery from the outskirts of Volokolamsk. For a long time he continued as a novice at the monastery, but later he settled on the eastern shore of Lake Kuben near the mouth of the River Kushta.
Labels: Saints of January, Saints of Russia, Saints of September
Holy Martyr Alexander and the Thirty Martyrs With Him
Sts. Alexander the Martyr and the 30 Martyrs with him
(Feast Day - September 28)
Alexander the leader had his end,
Three times ten in number men were decapitated.
The Holy Martyr Alexander and the Thirty Martyrs with him met their end by the sword.
Sts. Eustathios the Roman and Kallinikos (Feast Day - September 28)
A Roman, as well as strong,
Was the Martyr Eustathios who contested towards the sword.
The Holy Martyrs Eustathios the Roman met their end by the sword. Kallinikos is also mentioned with him as a Martyr, but we have no iambic verses for him.
Holy New Hieromartyr Anthimos the Iberian, Metropolitan of Wallachia (+ 1716)
St. Anthimos the Iberian (Feast Day - September 27)
Saint Anthimos was born in Georgia, and his parents were called John and Maria. The child received the name Andrew in Baptism, and his parents raised him in piety as an Orthodox Christian.
Andrew was captured by Turks who invaded Georgia when he was young, and he was one of many who were made slaves in Constantinople. There he learned to speak Greek, Arabic, and Turkish, and also became skilled in woodcarving, embroidery, and painting. After a few years as a slave, Andrew escaped and fled to the Ecumenical Patriarchate for refuge.
Labels: Orthodoxy in Romania, Saints of Georgia, Saints of Romania, Saints of September
Saint Sabbatius of Solovki the Wonderworker (+ 1435)
St. Sabbatius of Solovki (Feast Day - September 27)
Saint Sabbatius of Solovki came to the Saint Cyril of White Lake Monastery (Kirillo-Belozersky Monastery) in the year 1396, where he received the monastic tonsure. He there pursued asceticism for a long time, unquestioningly fulfilling all obediences. His humility, gentle love towards the brethren and his strict life distinguished the monk Sabbatius among his fellow ascetics. He soon became burdened by the attention and esteem of the brethren and laity coming to him, and having learned that on Lake Ladoga is the rocky island of Valaam, he decided to settle there.
Holy Apostles Mark, Aristarchus and Zenon of the Seventy
Sts. Mark, Aristarchus and Zenon of the Seventy (Feast Day - September 27)
To Mark.
He who is boastfully called John and Mark,
Excelled on the path of the Apostles.
To Aristarchus.
Aristarchus was an excellent initiate of the Word,
Beginning in excellency and living the life of a stranger.
To Zenon.
Zenon preached the Word of the living God,
Reviving very many who were dead in error.
Labels: 70 Apostles, Saints of September
Sts. Philemon the Bishop and Fortunianus (Feast Day - September 27)
The friend of Christ Philemon the sacrificer loved,
Fortunianus who contested with him and loved in return.
The Holy Marytrs Philemon the Bishop and Fortunianus were martyred for their confession of Christ. Nothing else is known of their life or death.
Holy Fifteen Martyrs (Feast Day - September 27)
The company of three times fives athletes,
Descended to the bottom of the sea.
The Holy Fifteen Martyrs were drowned after being put out at sea on a ship that had holes in it.
St. Gaiana the Martyr (Feast Day - September 27)
Gaiana gave her back to the flames,
As if she saw the back of the flaming sword.
The Holy Martyr Gaiana met her end by being burnt on her back.
Saint Ephraim of Perekop the Wonderworker (+ 1492)
St. Ephraim of Perekop (Feast Day - September 26)
The Venerable Ephraim of Perekop was born on September 20, 1412 in the city of Kashin. In Holy Baptism he was named Eustathius. His parents, Stephen and Anna, lived not far from the Kashin women's monastery named in honor of the Dormition of the Most Holy Theotokos.
Drawn to the solitary life, Eustathius left his parental home while still in his early years and settled in the Kalyazin Monastery of the Most Holy Trinity. His parents wanted their son to return home, but he persuaded them to leave the world and accept monasticism. Later, they also finished their earthly paths living as hermits.
St. Chera the Martyr (Feast Day - September 26)
Chera was slain for you O Word her bridegroom,
Having written the contract in her blood.
The Holy Martyr Chera met her end by a knife.
When Fr. Benedict Petrakis Resurrected his Dead Benefactor
Archimandrite Benedict Petrakis (+ September 8, 1961) developed a magnificent pastoral activity in the Metropolis of Aitoloakarnania and especially in Agrinio. Many spiritual branches of this region bore fruit through his systematic work and his exceeding love for God and neighbor.
When he was young and wanted to study theology, he was helped financially by a pious woman from Patras, Melpomeni Bulbasakos. And when he became a mature preacher in Aitoloakarnania, he received a phone call informing him that his benefactor was near death and he was requested to go and give her final communion.
Labels: Fr. Benedict Petrakis, Holy Eucharist
St. Euphrosyne of Suzdal (Feast Day - September 25)
Saint Euphrosyne, Princess of Suzdal, was born in the year 1212. In holy baptism she was given the name Theodoulia and she was the eldest daughter of the Holy Martyr Michael, Prince of Chernigov (Sept. 20). Prince Michael and his wife Theophania did not have children and they often visited the Kiev Caves Monastery, where they prayed the Lord to grant them children. Princess Euphrosyne was their first daughter, sent from God in answer to their prayer. Three times the Most Holy Theotokos appeared to them and said that their prayer had been heard and that the Lord would grant them a daughter.
Labels: Female Saints, Saints of Russia, Saints of September
Saint Arsenius the Great, Catholicos of Georgia (+ 887)
St. Arsenius the Great of Georgia (Feast Day - September 25)
Saint Arsenius the Great, a pupil and spiritual son of Gregory of Khandzta, was the youngest son of a certain aristocrat, Mirian, from Meskheti in southern Georgia.
On their way to Abkhazeti, Saint Gregory's companions Theodore and Christopher stopped in Meskheti at the home of Arsenius' family. Mirian and his wife, Kravaia, asked the monks to bless their children and, astonished at the fathers' virtue, they entrusted their youngest son to their care.
Gregory of Khandzta later traveled to Abkhazeti to visit Theodore and Christopher, and on his way back to the monastery he brought with him the young Arsenius, the future catholicos of Georgia, and the youth Ephraim, the future wonderworker and bishop of Atsquri. The monks Theodore and Christopher journeyed with them as well.
Labels: Saints of Georgia, Saints of September
St. Sergius of Radonezh (Feast Day - September 25)
About St. Sergius
Saint Sergius the Wonderworker, Abbot of Radonezh (+ 1392)
Life of our Venerable Father Sergius of Radonezh
Saints Cyril and Maria, Parents of Saint Sergius of Radonezh (+ 1337)
The Appearance of the Most Holy Theotokos to St Sergius of Radonezh
Labels: Saints of Russia, Saints of September, St. Sergius of Radonezh
Holy Martyrs Paul and Tatta and their children Sabinian, Maximos, Rufus, and Eugene
Sts. Paul, Tatta, Sabinian, Maximos, Rufus and Eugene (Feast Day - September 25)
Paul the father was martyred with his children,
Together with Tatta who was arrayed with the same mind.
Saints Paul and Tatta, who were yoked together, with their four children Sabinian, Maximos, Rufus, and Eugene, were from Damascus. Having been accused of being Christians, their feet were fastened in stocks and bound with chains. Having been sentenced, they were harshly beaten. The unbelievers then dislocated the members of their bodies, and by this they delivered their souls into the hands of God, from Whom they received crowns of martyrdom.
Labels: Children Saints, Early Christian Martyrs, Married Saints, Saints of September, Saints of Syria
The stream of the Filerimos Icon floods,
Those who approach it with healings.
On the twenty-fourth we celebrate the Lady Filerimos.
The Holy Monastery of the Panagia of Filerimos is situated amid idyllic scenery on Filerimos hill that dominates the namesake bay at an altitude of 247 meters. Following the main road from Rhodes Town to Ialyssos and turning left on the Ialyssos main crossroad you will reach the foot of Filerimos hill. The site appears to have been attractive from ancient times. The Acropolis of Ialyssos and the ancient temple of Athena Poliados, which, in the 5th century A.D., became a Christian three-aisled basilica, were at the same location. The only remains of this basilica is a cross-shaped font. Passing through the eastern gate, a wide stone staircase, with tall cypress trees right and left, leads us to the Monastery of Panagia Filerimos dedicated to the Zoodochos Pigi (Life-Giving Spring). The church complex was built by the Knights of Saint John over an older Byzantine church and was rebuilt in its present form by Italian archaeologists. Right next to the font is the restored stone Gothic church.
Labels: Orthodoxy in Serbia, Orthodoxy in the Dodecanese, Theotokos Icons
Holy Venerable Martyr Galaction of Vologda (+ 1612)
St. Galaction of Vologda (Feast Day - September 24)
Fearing the wrath of Tsar Ivan the Terrible, kinsmen of the disgraced prince Ivan Ivanovich Belsky secretly brought his seven-year-old son Gabriel to the city of Staritsa. In the years of his growing up, and seeing the malice of the Tsar towards his family, the young prince withdrew to Vologda and lived with a shoemaker, from whom he learned the cobbler's craft. His marriage did not last long, for his wife soon died, leaving Prince Gabriel to raise his infant daughter.
The adversities of his earthly life strengthened in him the intent to devote himself to God. Having sought out a place at the River Sodima, he dug a pit and made his cell near a church named for the Most Holy Trinity. After being tonsured with the name Galaction, he began to labor in fasting and prayer. The ascetic did not give up his cobbler's trade, and the money which he received from the work was divided into three portions. One part he dedicated to God, another portion he gave to the poor, and the third part he kept for his own needs.
St. Nicander of Pskov (Feast Day - September 24)
Saint Nicander of Pskov (in Baptism Nikon) was born on 24 July 1507 into the peasant family of Philip and Anastasia in the village of Videlebo in the Pskov lands.
From childhood he dreamed of continuing the ascetic exploits of his fellow villager, Saint Euphrosynus of Spasoeleazar, the original Pskov wilderness-dweller (May 15). The first in Nikon's family to accept monasticism was his older brother Arsenius. After the death of his father, the seventeen-year-old Nikon was able to convince his mother to dispose of the property and withdraw into a monastery, where she lived until her own end.
St. Dorothy of Kashin (Feast Day - September 24)
By Fr. Seraphim Rose
Saint Dorothy was born in 1549, in the prosperous early part of the reign of Ivan IV (the Terrible), and died in 1629 during the peaceful reign of the first Romanov Tsar, Michael Theodorovich; but her whole life, beginning when she was twelve years old, passed in the midst of the most frightful conditions of rebellion, anarchy, famine, plague, and foreign invasion.
This holy nun of the latter times was of noble blood, and some say that she was of the family of the Princes Korkodinov, but neither her place of birth nor her name before receiving the monastic tonsure are known to us. She was given in marriage to Theodore Ladygin and by him had a son, Michael; they lived in the region north of Moscow, where the city of Kashin is located. In the first decade of the 17th century, Kashin was laid waste by invading Poles and Lithuanians, and St. Dorothy's husband fell on the field of battle in defence of the city.
Labels: Female Saints, Fr. Seraphim Rose, Saints of Russia, Saints of September
Encomium on the Conception of Saint John the Baptist (St. Sophronios of Jerusalem)
By St. Sophronios of Jerusalem
Let us speak of the wonderful conception of the Honorable Forerunner - since it could stand as the beginning of the whole narrative - and put in order what we are triumphantly about to mention, insofar it pleases him whom we are praising today to give us the power of speech. But it might be better to begin our talk with events that preceded the conception. In this way we can demonstrate that, even before his conception, it was clear that he would become a great and important person and that he would meet the expectations of people in matters of salvation, since he would not be exempt from the consequences which the fall of the Adam and Eve had for the whole of humankind. As a result of this fall, we had reached the point where we were living on earth in misery and degeneracy, as the general legatees of God's decision: "You are dust and shall return to dust" (Gen. 3, 19).
Labels: Saints of September, St. John the Baptist, St. Sophronios of Jerusalem
Conception of Saint John the Baptist Resource Page
Conception of St. John the Forerunner (Feast Day - September 23)
The man received a prophetic oracle from the Archangel,
You will beget a Prophet, and even greater than the prophets.
On the twenty-third the Forerunner appeared and received the womb.
Synaxarion for the Conception of the Honorable Prophet, Forerunner and Baptist John
The Conception of Saint John the Forerunner
Labels: Saints of September, St. John the Baptist
On the island of Patmos, in the main church of the Monastery of Saint John the Theologian, is a western-style image of the Holy Mandylion dating to the end of the 18th or beginning of the 19th century. It seems almost out of place inside the old temple filled with Byzantine-styled frescoes. Artistically it is less interesting than anything around it, being a simple image on wood with a wood-carved frame, but it has a fascinating history in and of itself, especially how it came to be displayed in the most sacred church on the island.
Labels: Acheiropoieton, Orthodoxy in the Dodecanese, Weeping Icons
Sts. Isaac and Martin the Martyrs (Feast Day - September 22)
To Isaac.*
Isaac the child of Sarah came short of suffering,
Isaac the new paid in full by being slain.
To Martin.
Inspired from above with the courage of Christ,
Martin hastened to the sword and expired.
The Holy Martyrs Isaac and Martin met their by the sword.
Saint Isaac is also commemorated on December 9th.
Holy Martyrs Eusebius, Nestabus and Zeno who were Brothers
Sts. Eusebius, Nestabus and Zeno of Gaza (Feast Day - September 21)
Eusebius, Nestabus, as well as Zeno,
Died for their pious faith by a sword.
By Sozomen
(Ecclesiastical History, Bk. 5, Ch. 9)
Martyred During the Reign of Emperor Julian the Apostate (361-363).
As I have advanced thus far in my history, and have given an account of the death of George and of Theodoritus, I deem it right to relate some particulars concerning the death of the three brethren, Eusebius, Nestabus, and Zeno. The inhabitants of Gaza, being inflamed with rage against them, dragged them from their house, in which they had concealed themselves and cast them into prison, and beat them. They then assembled in the theater, and cried out loudly against them, declaring that they had committed sacrilege in their temple, and had used the past opportunity for the injury and insult of paganism. By these shouts and by instigating one another to the murder of the brethren, they were filled with fury; and when they had been mutually incited, as a crowd in revolt is wont to do, they rushed to the prison. They handled the men very cruelly; sometimes with the face and sometimes with the back upon the ground, the victims were dragged along, and were dashed to pieces by the pavement. I have been told that even women quitted their distaffs and pierced them with the weaving-spindles, and that the cooks in the markets snatched from their stands the boiling pots foaming with hot water and poured it over the victims, or perforated them with spits. When they had torn the flesh from them and crushed in their skulls, so that the brain ran out on the ground, their bodies were dragged out of the city and flung on the spot generally used as a receptacle for the carcasses of beasts; then a large fire was lighted, and they burned the bodies; the remnant of the bones not consumed by the fire was mixed with those of camels and asses, that they might not be found easily.
Labels: Early Christian Martyrs, Saints of September, Saints of the Holy Land
Holy Six Martyrs, who were Armor-Bearers of Emperor Maximian
Holy Six Martyrs (Feast Day - September 21)
For God who bent his head on the wood,
Six Martyrs bent their heads to the sword.
In the year 298 the Holy Six Martyrs, who were armor-bearers of Emperor Maximian, were beheaded for confessing Christ.
St. Eusebius the Martyr (Feast Day - September 21)
The impious slew Eusebius with a sword,
He who lived piously and was a friend of Christ.
Saint Eusebius appeared of his own free will before the prefect of Phoenicia, and said to him: "What senseless deed are you doing, O prefect, persecuting the flock of Christ?" This enraged the prefect, who ordered for the athlete of Christ to be suspended and lacerated. Then with hair cloths tied together, the wounds of his members were rubbed down. The Martyr rejoiced and was glad, as if it was someone else suffering, and not himself. This bewildered the prefect, and not knowing what to do, he ordered for his beheading. In this way the blessed one ascended into the heavens, in order to receive the unfading crown of martyrdom.
Holy Prince Oleg of Briansk, who was Tonsured with the name Basil (+ 1285)
St. Oleg of Briansk (Feast Day - September 20)
Holy Prince Leontius Oleg Romanovich of Briansk was grandson of the holy martyr Prince Michael of Chernigov. According to the chronicle histories, Prince Oleg together and his father, Prince Roman Mikhailovich of Briansk, participated in a war against Lithuania in 1274.
Holy Martyrs Michael the Prince of Chernigov and Theodore his Boyar (+ 1246)
St. Michael of Chernigov and Theodore his Boyar (Feast Day - September 20)
Saint Michael (Mikhail) of Chernigov was the son of Vsevolod Svyatoslavich (who later became grand prince Vsevolod IV the Red of Kiev), by Anastasia, the daughter of grand duke Casimir II of Poland. The patrimonial domain of his father was located in the northwestern part of the Vyatichi lands where he undoubtedly spent his childhood. He was noted from childhood for his piety and mildness.
Holy Venerable Martyr John the Egyptian and the Forty Martyrs With Him
St. John of Egypt together with Forty Martyrs (Feast Day - September 20)
John together with the decad of four,
Firmly approached decapitation by the sword.
Because the lawless and impious Maximian could not endure the boldness through Christ of Saint John, he ordered that he be killed by a sword with forty others in the year 295. In this way the blessed ones received crowns of martyrdom.
Sts. Artemidoros and Thallos the Martyrs (Feast Day - September 20)
Artemidoros and Thallos were slain by the sword,
For not venerating Artemis the slayer of strangers.
The Holy Martyrs Artemidoros and Thallos met their end by the sword because they refused to deny Christ and worship idols.
Rufinus visited Oxyrhynchus in the 370's, and was the first to describe in the Latin language an Egyptian city so thoroughly Christian, it can be adequately described as a city of God on earth. The city had a population of male and female monastics which were more in number than regular inhabitants, with twelve churches and numerous monasteries. Some believe Rufinus was exaggerating his account to rouse the imaginations of Christians in the West, but we know that the twelve churches he describes in the city of his time had increased to forty or more by 535 A.D. No doubt it was an important Christian center in its time, and the disappearance of its numerous churches and monasteries especially due to the Islamic conquest is much to be regretted. Today relics of its Christian past can still be seen in some pillars in the chief mosque of Behnesa, and a single Corinthian column in the modern Coptic cemetery in the desert to the southwest of the town ruins.
Labels: Desert Fathers, Rufinus of Aquileia
Holy Martyrs Bidzina, Shalva and Elizbar, Princes of Georgia (+ 1661)
Sts. Bidzina, Shalva and Elizbar the Princes of Georgia (Feast Day - September 18)
In the 17th century the Persian aggressors razed churches, monasteries, and fortresses and drove out thousands of Georgian families to resettle them in remote provinces of Persia. The deserted territories were settled by Turkic tribes from Central Asia. In the chronicle The Life of Kartli it is written: "The name of Christ was not allowed to be uttered, except in a handful of mountainous regions: Tusheti, Pshavi, and Khevsureti."
But the All-merciful Lord aroused a strong desire in the valiant prince Bidzina Choloqashvili of Kakheti and, together with Shalva and his uncle Elizbar, princes of Aragvi and Ksani provinces, he led a struggle to liberate Kakheti from the Tatars. (The Persian governor of Kakheti, Salim Khan (1656-1664), had been encouraging the Tatar tribesmen to profane the Christian churches.)
St. Kastor the Martyr (Feast Day - September 18)
Kastor was not a wild beast, but a noble man,
Or rather we should say he was a brave man who was assaulted.
All we know of Saint Kastor is that he was martyred for his faith in Christ.
Sts. Sophia and Irene the Martyrs (Feast Day - September 18)
The heads of Irene and Sophia were cut off,
They beheld You who are peace beyond comprehension O Word.
The Holy Martyrs Sophia and Irene were from Egypt and were beheaded for confessing Christ during the reign of Emperor Aurelian (270-275), when Claudius was governor in Egypt. They are commemorated the day after the Holy Martyr Sophia and her daughters Faith, Hope and Love. There is an Athonite fresco with a scene of their martyrdom from 1547 at Dionysiou Monastery.
Holy Hieromartyrs Herakleides and Myron, Bishops of Tamassos in Cyprus
Sts. Herakleides and Myron of Tamassos (Feast Day - September 17)
Herakleides and Myron were assigned to the fire,
They approached Christ as fragrant myrrh.
Herakleides was the son of a pagan priest and lived in the village Lambadistos, in Cyprus. His father, although a pagan, was hospitable and did not hesitate to accommodate the Apostle Paul together with Barnabas and Mark when they came to Cyprus. The Apostles however refused to dine with one who sacrificed to idols, but instead asked for a guide around the island. Herakleides' father gladly volunteered his son. The Apostles led Herakleides to the faith of Christ, since he was eager to learn, and he in turn, led his parents. It is said that his name was first Herakleon but changed by Saint Paul upon his baptism to Herakleides. Saint Barnabas on his second trip to Cyprus appointed him Bishop of Cyprus and placed him in Tamassos. He is said to have built churches, cured diseases, raised the dead, cast out demons, and worked innumerable wonders. Herakleides worked with great zeal along with his disciple Myron, his successor as Bishop of Tamassos, for the dissemination of Christianity with impressive results, and many pagans believed in Christ. His successes however agitated the unbelievers, who killed them by burning them alive.
Labels: Demonology, Saints of Cyprus, Saints of September
Holy Martyrs Haralambos and Panteleon with their Companions
Sts. Haralambos and Panteleon and those with them
On his way to the slaughter Haralambos rejoiced,
And Panteleon was like a lion on his way to the knife.
The Holy Martyrs Haralambos and Panteleon with their companions suffered martyrdom for Christ. Their synaxis was celebrated in their Martyrium at the Deuteron district of Constantinople.
Labels: Constantinople, Early Christian Martyrs, Saints of September
Holy Martyrs Maximos, Theodotos, Hesychios and Asklepiodota
For September 17
To Maximos, Theodotos and Asklepiodota.
One woman and two young men,
Went to decapitation with one burning heart.
For February 19
To Maximos, Theodotos and Hesychios.
Three strong men contested together,
Being brave even to decapitation for you Trinity.
To Asklepiodota.
Christ crowned Asklepiodota,
She whose head was cut off by the sword.
Labels: Early Christian Martyrs, Saints of February, Saints of September
Gospel Commentary for the Sunday After the Holy Cross (St. Theophylact of Ochrid)
Sunday After the Holy Cross
Mark 8:34-38; 9:1
From the Homilies on the Gospel of Saint Mark
By Blessed Theophylact of Ochrid
34-37. And when He had called the people unto Him with His disciples also, He said unto them, Whosoever desireth to follow after Me, let him deny himself, and take up his cross, and follow Me. For whosoever desireth to save his life, shall lose it; but whosoever shall lose his life for My sake and the Gospels, the same shall save it. For what shall it profit a man, if he shall gain the whole world, and lose his own soul? Or what shall a man give in exchange for his soul?
[In this passage of St. Mark, and in the following commentary, the single Greek word, psyche, has been translated as either "life" or "soul" as it has both these meanings. See also Theophylact's Explanation of St. Matthew, pp. 30, 61, and 193. Tr.]
Since Peter had rebuked Him for wanting to be crucified, the Lord called the people unto Him, and said in the hearing of all, but directing His words mostly towards Peter, "Do you find fault with Me, Peter, because I take up the cross? I say to you, that neither you, nor anyone else, will be saved unless you die for the sake of goodness and truth." See that Christ does not compel a man to die on a cross against his own will. Instead He said, Whosoever desireth. The Lord is saying: "I compel no one. I invite him to something good, not to something bad to which he must be forced. Whoever does not want these things is not worthy of them." We can learn what it means to deny oneself if we understand what it means to deny another. He who denies another is he who, when he sees his brother, or servant, or father, being flogged or even murdered, does not turn towards him and pity him in his suffering, but acts as if he were a stranger to him. In this same manner the Lord wants us to show no pity towards our own bodies, so that even if we are flogged, or worse, let it make no difference to us. Let him take up his cross, that is, accept a most shameful death, for at that time to die on a cross was considered the most shameful of deaths. But since many were crucified for being bandits, the Lord added to the crucifixion something else: that one ought to have virtue. This is what it means to follow Me. Although His command that one give oneself over to death seemed hard and cruel, the Lord straightway shows this commandment is given out of love for mankind. For whosoever shall lose his life for My sake shall find life. (But the death of a condemned man, or of one who hangs himself, is not for Christs sake and brings no such reward.) And, on the contrary, he who appears to have saved his life, far from finding life, shall lose it by not remaining steadfast during his time of martyrdom. Do not say to Me, "But he has saved his life", it means nothing. Even if you say that he has gained the whole world as well, it is of no benefit. No one can exchange money for his salvation, for if that were so, a man who had gained the world but lost his soul, could, while burning in the flames of hell, use his money to buy innocence. But at that time and in that place no such trade can be made. Here let us shut the mouths of those who say, following Origen, that all the souls in hell will be restored [and reunited with those in heaven] after they have been punished in accordance with their sins. (1) Let them hear that there is no exchange that can be made there for ones soul. No one is kept in hell as a punishment. Rather, it is the weight of his own sins which holds him there.
38-9:1. Whosoever therefore shall be ashamed of Me and of My words in this adulterous and sinful generation; of him also shall the Son of Man be ashamed, when He cometh in the glory of His Father with the holy angels. And He said unto. them, Verily I say unto you, that there be some of them that stand here, which shall not taste of death, till they have seen the kingdom of God come with power.
Intellectual faith does not suffice, but confession of faith with ones mouth is required as well. Since man himself is two-fold, let his sanctification be two-fold as well. The soul is sanctified by faith, but the body is sanctified by confessing. Whosoever therefore shall be ashamed to confess that the Crucified One is his God, of him also shall the Crucified One be ashamed. For the Lord shall judge that man to be an unworthy servant, when He comes with glory, escorted by the angels, and no longer in lowly form. At the second coming He will not appear, as He did before, to be of base origin and circumstance, and an object of scorn. Since He speaks of His own glory, He desires to show that He is not vainly boasting, and says, There be some of them that stand here, namely, Peter, James, and John, who shall not die until I have shown them at the Transfiguration the glory with which I shall appear at the second coming. For the Transfiguration was nothing less than a foreshadowing of the second coming, and as He appeared in radiance then, so will He shine at the second coming, as will also all the righteous.
1. This false teaching of Origen, apokotastasis, the general restoration of all fallen creation, was condemned by the Church as heresy at the Fifth Ecumenical Council held at Constantinople in 553 AD.
Labels: Cross, N.T. - Mark, St. Theophylact of Ochrid, Sunday Gospel Readings
Origins of the Feast of the Exaltation of the Holy Cross
By Louis van Tongeren
The roots of the feast of the Exaltation of the Cross lie in Jerusalem and go back to the fourth century. The oldest sources associate the observance with the annual feast of Dedication of two churches built at sacred sites in Jerusalem: the Martyrium on Golgotha and the Anastasis rotunda, located over Jesus' tomb and therefore also called the Church of the Holy Sepulchre or the Church of the Resurrection. According to the oldest stratum of the Armenian Lectionary, which goes back to the liturgical customs of Jerusalem circa 415, the feast of the Dedication of the two churches, which was celebrated for eight days, began on September 13 in the Anastasis. On the second day (September 14) people gathered in the Martyrium and "the venerable, life-giving Holy Cross was displayed for the whole congregation." Here we do not yet find an independent feast of the Cross with a name of its own. The feast focuses on commemorating the Dedication of the two churches. The term "Exaltation" is first used in the sixth century by the monk Alexander of Cyprus (527-565), when he reports that "the Fathers, commanded by the Emperor, determined that the day of the Exaltation of the venerable Cross and of the Dedication should be celebrated annually on September 14, in honor of the Father, the Son and the Holy Spirit." For Alexander too the celebration is a combination of Exaltation and Dedication.
Labels: Cross, Liturgics, Saints of September
By St. Nikodemos the Hagiorite
The Christians of old were accustomed to carry on themselves the Cross of Christ, made either out of wood, gold, silver or some other metal, for their protection and salvation. For this reason Saint Pankratios the Bishop of Taormina, who is celebrated on the ninth of July, when he baptized Christians, he gave to each of them a Cross made from cedar to carry on them. And Gregory the Theologian carried a Cross towards the averting of every adversary. For this reason he spoke to the devil in meter:
Labels: Cross, St. Nikodemos the Hagiorite


The federal government has finally stepped into the Obafemi Awolowo University situation. According to public announcement on NTA Reaching NGschoolz.com Team. The process of VC selection has been suspended and the VC is to hand over all necessary things to the Registrar.
Salami ordered to vacate seat. Federal government dissolves governing body.


Used to neutralize and rinse floors after cleaning with TurboJuice Red or TurboJuice Blue. Safe on almost all surfaces. It can be used as a stand alone maintenance cleaner for manual or automatic scrubbing on resilient floors, linoleum, vinyl tile, marble, concrete, terrazzo and rubber. It dissolves and emulsifies soil, dirt and grease. Keeps your floors shiny clean.


text:
Q: Distorted UI onReceive of Admob Ads
The android UI gets distorted whenever the admob ads show up. And this happens on screens, which have some animations playing. On this screen I have a button animating with android:repeatCount="infinite".
I have observed this behavior since I have changed the admob Ad Id to the new Admob ID (after migrating to new Admob). Please help!!

A: This is an open issue reported to android issue tracker check
Rendering glitch on View since Android 4.4.3.
https://code.google.com/p/android/issues/detail?id=70914
As a workaround which I also have in my apps is setting a layertype
yourView.setLayerType(View.LAYER_TYPE_SOFTWARE, null);

or
 yourView.setLayerType(View.LAYER_TYPE_HARDWARE, null);

In my testing both solved the issue. You may need to add checks for android version as setLayerType was added in API 11 if you are supporting apps all the way to GingerBread

A: Go to  Androidmanifest  file and add the below line of code, it will work

<application
             android:hardwareAccelerated="true"
         <activity
                   android:hardwareAccelerated="false"
         </activity>
</application>

redpajama_set_name: RedPajamaStackExchange


text:
Press Start | What We Played
By: Jennifer Kibble
Published: Nov 4, 2013
Welcome to Press Start! This is a weekly segment where we here at The Game Fanatics share what we've been playing for the past week.
Nick P.:
I've been pillaging away at Assassin's Creed IV. The entire at-sea gameplay is pretty rich that I think it could pass as its own game. Upgrading your ship and fending off opposing vessels is often fun, but the best nautical moments are when you board a ship you've weakened (and the carnage that ensues). Now that makes me feel like a pirate.
Jen:
Since I've finished up with all of the story arc in Star Wars: The Old Republic, I've decided to start playing Dungeons and Dragons Online. My DM and a few other people that I play pen and paper D&D with recommended it. The game is fun but it isn't anything that I would spend actual money on. I played a little bit of Grand Theft Auto V but then the game froze on me again and I gave up. I've already beaten the game I just wanted to mess around. And I, like many others, are still waiting for that money that Rockstar promised.
Tagged: Assassins Creed 4, GTA V, what we played
Filed Under: Features
Jennifer Kibble
In Case You Missed It – Gaming News for the Week of April 17 – 23, 2017
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Déjà vu? GTA V Launch Trailer for PS4, Xbox One Released
Grand Theft Auto Online San Andreas Flight School Update Takes Off, Adds Much Needed Gameplay Changes
Press Start | Here's What We Played
Ten New User-Created Missions for GTA Online


Shed Roll Up Door – Shed doors are one of the most important parts of the ship, as they will be the most used in the structure of the shed and have to be sturdy enough to open and close regularly, and still maintain the safety of the ship. Materials, hinges, thickness and the opening of the capabilities of all that come into play when considering how to build the doors of your shed and help ensure that the product better built.
The decision on the size of the doors is the first step for the manufacture of high-quality doors. Usually, the bigger the better and when you do not know how many things you could end up in your storage shed and, as with most sheds, you often end up storing more things in them in recent years. Consider what can be stored inside and build your doors outside of that. While the doors can be superimposed on the actual shed structure, especially when the hinges are on the outside, the larger the doors usually means the larger the shed.
Most sheds are made of wood or composite wood, but some are made of metal or have aluminum cladding installed on them. Usually, it is good to build your doors out of the same material that the rest of the shed is built from. That said, wood is usually the easiest way to build heavy doors and in the most cost-efficient way. If the ship is covered with metal cladding, then the doors should be covered in the aluminum cladding as well, just so that everything looks uniform. The wooden doors are also good because they are thick enough to actually hang things from the inside, which helps maximize the storage capacity of the shed itself.


There aren't too many comedians who could boast that they have changed the face of comedy, but John Cleese can, even if he is far too modest to make such a claim.
From Monty Python to Fawlty Towers, Cleese has created some of the funniest and most enduring characters of our time.
At the age of 75, he is showing no signs of retiring, having just written an autobiography. While the book explains a lot about Cleese, he cannot explain why he makes us laugh.
"The loveliest thing anyone ever said … was when I watch Monty Python, I cannot then go on and watch the evening news, I cannot take it seriously," Cleese said.
After more than 50 years in the business, Cleese said he is still unsure why some things are just funny.
"I think it's lovely when you can do things that have no meaning that are still funny," he said.
It is a brand of humour that has propelled Cleese to international stardom.
He has played everything from 007's sidekick to a bumbling barrister in A Fish Called Wanda.
He has been a writer, actor and comedian, but right from the start Cleese has used humour to make a point, sending up the very world he lived in.
"If you want to see how to behave as an upper class person, go and watch the baboons," he said.
After Cleese's third marriage ended he was forced to undergo what he called his "Alimony Tour".
"I've had to pay her $20 million, it's not fair," he said.
At 75, Cleese is still going strong, but his legendary role with Monty Python is now done.
He said the reunion made him realise that.
"I remember thinking 'how extraordinary that I don't feel excited'," he said.
For Liz Hayes' full interview with John Cleese, watch in the player above.


You are visiting the placeholder page for Regina Gunter. This page is here because someone used our placeholder utility to look for Regina Gunter. We created this page automatically in hopes Regina Gunter would find it. If you are not Regina Gunter, but are an alumni of Pleasant Hill High School Pleasant Hill, CA, register on this site for free now.


Some users have recently reported that they get stuck on the Windows 10 login screen when attempting to remotely access a machine running on Windows 10 Fall Creators Update (1709). Every time they enter the Windows credentials, they're able to see the remote desktop for a second or two, but then get immediately logged out and have to type in the password again and again.
If you're experiencing the same infinite loop, one of the known solutions to get through it is to reboot the remote computer. Note that you can do this directly from the Windows login screen itself by clicking the Power button, then selecting Restart.
Our support team is still actively investigating this strange behavior, but at this point we suspect that it's attributed to some changes in the Fall Creators Update. Join us on Facebook, Twitter or LinkedIn and stay tuned for updates!


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How do I manage profile pictures for users in my account?
Profile pictures are public and automatically approved when users upload an image in their settings. If a user has a Gravatar, and chooses not to upload a profile picture, the Gravatar will show up. If a users reports an inappropriate profile picture to the administrator, they can choose to approve, lock, or delete the picture.
Click the Manage Profile Pictures button. Using profile pictures can make it easier to see the users in your account and managing them gives you the ability to keep the pictures appropriate.
Submitted which are the pictures that users have submitted but they haven't been approved or deleted.
Reported which are the pictures that have been reported.
Approved, Re-Reported which are the pictures that have been approved and re-reported.
All which are all the pictures within the account.
On individual profile pictures, you can either approve, lock, or delete the picture. Once the picture is approved, a green checkmark will appear next to the picture.


This cart was left unused for the Winter and had trouble starting. We take apart the carb and do a thorough cleaning.
Welcome to Kevin's Golf Carts YouTube Channel. We do golf cart repair videos to help you get your golf cart running again.
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Very informative video and tips.. Great lighting in the video..
What kind of carb cleaner do you use. I used that purple power and made the aluminium turn dark grey/ black. What do you suggest. I just looked at your store and will be ordering a few things. Do you ship to Canada.
Good job on the repair Kevin.
Thought you were building a new shop? Maybe I missed something. Have to catch up on your videos. Great video either way…………..


Ever notice how some folks can't resist touching a surface even though a sign sends a warning? For these individuals, WET PAINT is almost an invitation to ignore the warning. Although your fireplace or stove likely does not have a HOT SURFACE warning sign, dangers loom, especially for children. What can you as a homeowner do to lower risks and add protection related to fireplace and stove glass safety? At Old Smokey's Fireplace & Chimney, our highly trained professionals can help. Whether it is advice or accessories you need, we are ready, able — and smart.
Fireplace and stove glass safety naturally relies on some degree of human intervention. Of course, you want to be careful that young children don't touch the heated glass. Even after the fire is out, glass fronts and surfaces of your stove and fireplace can remain hot for long periods. Use common sense and monitor young ones at all times.
Beyond that, a few simple accessories can add a layer of safety and protection for all. As recommended by the Hearth, Patio & Barbecue Association, or HPBA, free-standing or attached safety screens or gates provide a barrier making it harder for anyone, adult or child, to accidentally touch a hot surface.
There are three different types of protective barriers that are used for protection from harm to you or your family. The first kind are attachable safety screens for fireplaces that is isolated from the fireplace so it does not get hot and keeps anyone or any hands from getting too close to the fire. These are usually exact fit for the manufacturers specific fireplace. The second type are attached safety gates. These gates anchor to the wall and set up secure barriers for little ones to keep away from and you can feel safe that even if your child or pets are left unattended even for a second they will be safe from the fire. The third ind is unattached safety screens that are more decorative allow for easy access to the fire for attending, but are lightweight and do not offer the best security. A screen or protective barrier of any kind should be a must have for anyone with children or pets that will be around a fireplace or stove.
New technologies are being developed all the time, so it is important to know the safety features of fireplace products and the latest safety products available. Many fireplaces have a specific safety device for your unit; so contact the manufacturer with the model number of your appliance. Aftermarket screens and devices are available and you can always check with your local specialty retailer for more information on proper fitting. Always ensure the sturdiness of any screen or barrier so it cannot be removed by a pet or child. Be smart and do not take risks for any loose safety device.
Customers love us and we would be glad to help with any questions about adding safety to your heating appliances. Call the friendly folks at Old Smokey's today at 260-424-0009 or 800-876-6539 or click here any time to schedule an appointment.


This Times article describes the popularity of flexible working arrangements among Dutch workers and how it has become a "powerful tool to attract and retain talent — male and female — in a competitive Dutch labor market." While it suggests the trend has the potential to catch on elsewhere, it seems unlikely to gather real momentum in the United States. To gain widespread traction here (on more than just an individual company basis), businesses and workers would have to truly buy in to the mindset that part-time work is an equally valid lifestyle choice as full-time work and would essentially need to abandon many of the deeply-entrenched values of the competitive workplace. As attractive as this "new world of work" concept sounds, I find it hard to believe it would be acceptable to pass off a court date to a colleague as described in the article without earning a few scoffs in the process. You may be able to fend off the title of "Dutch princess" in the Netherlands, but the breaks are harder to come by when competition among both males and females is fierce and career ambition often trumps carving out quality family time.


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