text:
Esthetic-Tunisie
Let's Live Healthy
Start a Healtly Life
Tag: psychological
Guiding Depressed Millennials To Psychological Health
Posted on September 1, 2019 December 18, 2018
In America, there is a rising epidemic of obesity. Medicare now pays for up to 60 days of dwelling health providers if a physician certifies the affected person needs the services and submits a plan of care. Learn extra about how you can be a part of Healthcare Prepared and alternatives to companion with us. One examine discovered that amongst kids and teenagers with diagnosed mental health issues reminiscent of main despair and generalized anxiousness, solely about 10 {b667b7fee7f9e349e3849d7808d8734b30e1c2256b952c1054a03978c4d88e06} had been reported as having acquired any type of remedy or treatment.
For example, Beaumont staff can accrue as much as six weeks of paid trip a 12 months, but the house care nurses have had vacation time scaled back, vacation days down to two from six and quarterly bonuses eliminated, sources stated. For you and your loved ones, we're dedicated to being a folks-centered health care system that enables higher health, better care and lower costs.
6) Moisturize the Penis РAfter cleansing the skin, use a specifically concocted penis health cr̬me (health professionals suggest Man 1 Man Oil, which has been clinically confirmed protected and delicate for pores and skin) to the genital area with a soothing therapeutic massage.
Medical doctors, scientists and medical researchers weigh in on health care and better health practices. Veterinarians take care of the health of animals and work to enhance public health. While the U.S. Division of Health and Human Providers is attempting to spread this message, there are other actions being taken as well.
The main focus of public health interventions is to prevent and handle ailments, injuries and other health conditions by way of surveillance of circumstances and the promotion of healthy conduct , communities , and (in aspects related to human health) environments Its goal is to forestall health problems from happening or re-occurring by implementing educational packages , developing insurance policies , administering services and conducting research 51 In many instances, treating a disease or controlling a pathogen will be important to preventing it in others, resembling during an outbreak Vaccination programs and distribution of condoms to prevent the unfold of communicable ailments are examples of frequent preventive public health measures, as are educational campaigns to promote vaccination and the usage of condoms (together with overcoming resistance to such).
The inhabitants in query might be as small as a handful of individuals or as giant as all of the inhabitants of several continents (as an example, within the case of a pandemic ). Public health has many sub-fields, but typically includes the interdisciplinary classes of epidemiology , biostatistics and health providers Environmental health , neighborhood health , behavioral health , and occupational health are additionally necessary areas of public health.
In 2017, Beaumont Health consolidated its home health, hospice, dwelling infusion, sturdy medical equipment and private-duty nurse providers into Beaumont Home Health. Workplace wellness programs are more and more adopted by corporations for their worth in improving the health and properly-being of their staff, as are college health companies … Read More..
Penis skin health is one thing that always gets ignored. The Health Care Select Sector SPDR (XLV) fell 2 percent. Horvath is a seasoned leader with extensive expertise in healthcare provide chain operations and enterprise continuity. Mission: Defend, promote and improve the health and prosperity of individuals in Tennessee.
The population in question can be as small as a handful of people or as large as all of the inhabitants of a number of continents (as an example, within the case of a pandemic ). Public health has many sub-fields, however typically consists of the interdisciplinary categories of epidemiology , biostatistics and health services Environmental health , neighborhood health , behavioral health , and occupational health are additionally necessary areas of public health.
Doctors, scientists and medical researchers weigh in on health care and higher health practices. Veterinarians take care of the health of animals and work to enhance public health. While the U.S. Division of Health and Human Companies is attempting to unfold this message, there are different actions being taken as nicely.
31, 1987 could also be eligible for medical care via VA for 15 health conditions. Nevertheless, one early signal happened last yr when Beaumont brought back in house some formerly contracted out home health and hospice staff as employees. As represented right here, most program performance data are from the Health Division, but the scorecards continue to involve and show built-in, cross-sector work to enhance health.
Beaumont Health plans to sell as a lot as ninety percent of its seven-county residence health and hospice business and has created a three way partnership referred to as Beaumont Dwelling Health and Hospice LLC with Ohio-primarily based Alternate Solutions Health Community, Crain's has learned.… Read More..
Psychological Health First Aid
Be taught the newest health information along with easy methods to undertake a healthy lifestyle: From diet and weight loss tricks to advice on managing and preventing diabetes, we'll maintain you looking and feeling your finest. This work is overseen by the performance enchancment supervisor and the Performance Administration Committee, which has representation from across the division. The businesses had been beforehand a part of Beaumont Health System, Oakwood Healthcare and Botsford Hospital, legacy organizations that merged in 2014 to form Beaumont Health.
Our drive is to empower Americans to save lots of now and for the long run with a method that unites healthcare and retirement. Yale Occupational and Environmental Drugs Program , CT: Entered alliance to supply medical fellows and residents with steerage on health hazards and chemical exposures.
Britain will spend nearly $200 billion on its nationwide healthcare system in 2020, a sum equivalent to about 7{b667b7fee7f9e349e3849d7808d8734b30e1c2256b952c1054a03978c4d88e06} of GDP. Three sources said greater than 100 of Beaumont's home health and hospice intake staff, high quality assurance employees, medical information, workplace support and at the very least four schooling specialists can be laid off.
Public health has been described as "the science and artwork of preventing illness, prolonging life and promoting health via the organized efforts and knowledgeable selections of society, organizations, private and non-private, communities and people." 50 It's concerned with threats to the general health of a neighborhood based mostly on inhabitants health evaluation.
The President of the United States, with the assistance of the Department of Health and Human Services, is now launching a campaign referred to as "Small Steps." This program's purpose is to help Americans by making 3 small choices about their health to get large outcomes, instead of constructing a drastic way of life change.… Read More..
Penis skin health is one thing that always will get neglected. Britain will spend nearly $200 billion on its national healthcare system in 2020, a sum equal to about 7{b667b7fee7f9e349e3849d7808d8734b30e1c2256b952c1054a03978c4d88e06} of GDP. Three sources mentioned greater than one hundred of Beaumont's home health and hospice intake workers, quality assurance employees, medical information, office assist and a minimum of 4 training specialists could be laid off.
ResearchKit and CareKit Empowering medical researchers, doctors, and you. Crain's also spoke with a Beaumont residence health patient who stated she was told by her caregiver of the coming changes however had not obtained any official notification from Beaumont.
Right now, the Knowledge Explorer does not deal with efficiency but could also be helpful in your information-pushed discussions. Beaumont House Health was profitable, but under finances this 12 months as referrals have been down as a result of referring physicians at system hospitals have been sending more patients to other dwelling health businesses, two sources stated.
Performance-primarily based budgeting ensures that sub-grants and sub-contracts align associate and vendor work with public health priorities. Wait occasions, satisfaction scores, and quality comparisons for VA health care facilities. Convenience at your fingertips Sutter's My Health Online connects over 1 million patients such as you to their docs and health data anytime, wherever.
The inhabitants in query can be as small as a handful of people or as large as all of the inhabitants of a number of continents (for instance, within the case of a pandemic ). Public health has many sub-fields, but typically contains the interdisciplinary categories of epidemiology , biostatistics and health providers Environmental health , neighborhood health , behavioral health , and occupational health are also essential areas of public health.… Read More..
The Art And Science Of Psychological Health Nursing
Employment of healthcare occupations is projected to grow 18 {b667b7fee7f9e349e3849d7808d8734b30e1c2256b952c1054a03978c4d88e06} from 2016 to 2026, a lot sooner than the average for all occupations, adding about 2.4 million new jobs. One other factor for Beaumont and different hospitals to contemplate when changing submit-acute care services is financial losses they will incur due to Medicare's readmission penalties. Ana Gupte, Leerink Companions senior health care providers analyst, additionally expects the ruling to be overturned and sees a shopping for alternative for buyers.
The new bot would go to Babylon's own app users that December, then to patients of Britain's Nationwide Health Service sometime in the future. Cargill said several dwelling health corporations in Michigan have developed a wide range of formal and casual partnerships with hospitals to enhance sufferers' put up-acute care expertise and cut back inpatient readmissions.
Healthcare Prepared announced today the appointment of Erin Horvath to its board of directors. It capabilities on the program, organization, and system level to ensure the Health Division is using performance knowledge in choice making. We help countries obtain high-performing health methods by measuring health outcomes & the use of health system resources in addition to by analysing insurance policies that enhance access, efficiency & high quality of health care.
The Constitution of the One Health Fee is to 'Educate' and 'Create' networks to enhance health outcomes and effectively-being of humans, animals and plants and to promote environmental resilience through a collaborative, world One Health approach.
The Health Department efficiency administration framework helps arrange this effort by integrating with the State Health Evaluation, State Health Enchancment Plan, outcomes-based mostly legislation (Act 186), and core departmental operations. Keep linked together with your docs and entry your medical data, anytime, wherever.… Read More..
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text:
<?xml version="1.0" encoding="ascii"?>
<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN"
          "DTD/xhtml1-transitional.dtd">

  <title>spgl.gevents.GTimerEvent</title>
  <link rel="stylesheet" href="epydoc.css" type="text/css" />

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        Package spgl ::
        Module gevents ::
        Class GTimerEvent

[hide private]

[frames] | no frames]

Class GTimerEvent

source code

GEvent --+
         |
        GTimerEvent

This event subclass represents a timer event.  Timer events are
  generated by a GTimer object, which produces a new event at a fixed
  interval measured in milliseconds.  As an example, the following program
  generates a timer event every two seconds, stopping when the user clicks
  somewhere in the window:

       print "This program generates timer events."
       timer = gtimer.GTimer(2000)
       timer.start()
       while(True):
               e = gevents.waitForEvent(CLICK_EVENT | TIMER_EVENT);
               if (e.getEventType() == MOUSE_CLICKED):
                       break;
       print "Timer ticked"

        Instance Methods
        [hide private]

      void

          __init__(self,
        type=None,
        timer=None)

      Creates a GTimerEvent for the specified timer.

            source code

      GTimer

          getGTimer(self)

      Returns the timer that generated this event.

            source code

      string

          toString()

      Converts the event to a human-readable representation of the event.

            source code

Inherited from GEvent:
      getEventClass,
      getEventTime,
      getEventType,
      getModifiers,
      isValid,
      setEventTime,
      setModifiers

        Method Details
        [hide private]

__init__(self,
        type=None,
        timer=None)

(Constructor)

  	source code

Creates a GTimerEvent for the specified timer.

Parameters:

type (EventType) - the event type

timer (GTimer) - timer associated with event

Returns: void

Overrides:
        GEvent.__init__

toString()

  	source code

Converts the event to a human-readable representation of the
  event.

Returns: string

Overrides:
        GEvent.toString

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    Generated by Epydoc 3.0.1 on Fri May 10 02:58:16 2013

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redpajama_set_name: RedPajamaGithub


As some of you may know hard water gives bathtubs this yellowish/reddish streaks sometimes, not to mention hard water makes them even more difficult to clean. So, here I was cleaning my bathtub, when I decided I will pour some bleach and get it clean. When I came back an hour and a half later I was horrified to find out my bathtub now looks like a scene from a horror movie.
I went the same morning to just clean some light yellow streaks and I ended up with having a rusty red tub. After some research online I found the best ingredient and my best shot at getting rid of the streaks was to use some hydrogen peroxide.
If you can find it in a spray bottle that would be even better! If not, sprinkle, pour or rub, whatever you do just make sure you get it on all red streaks. Open the windows and make sure you ventilate the bathroom as chlorine gas is the by-product you don't want to inhale.
Following the images you will see how the nasty rusty streaks get whiter and whiter 2 minutes and 10 minutes later.


Home / المعرض / PREVIEW: Get ready for SEMA 2014!
Here in the UK the automotive show scene has all but drawn to a close by November (excluding the fantastic NEC Classic Car Show), but across the pond in America the largest tuning event in the world is just about to take place – SEMA 2014. For those unfamiliar with SEMA, this gigantic event takes over the Las Vegas Convention Centre attracting more than 60,000 domestic and international buyers throughout November 4th-7th.
It's the only place you can guarantee to see the latest product developments, demo cars and trade stands under one roof, and as you'd expect Meguiar's always puts on a serious show here!
In addition to the traditional indoor stand (showcasing the entire car cleaning product range), Meguiar's also hosts the 'Car Crazy' stage located in the outside arena of the Las Vegas Convention Centre. As the name suggests, this stage is dedicated to those die-hard automotive fans who take a huge amount of pride in displaying their Meguiar's-prepped rides over the SEMA event.
From classic American muscle to the latest high-performance Japanese imports, the Meguiar's Car Crazy stage covers all aspects of automotive tuning with dozens of cars on display outdoors. Every car has its own unique story, and the Car Crazy stage is the perfect place to hear every one.
With the gates officially opening later today we'll be bringing you SEMA updates throughout the entire week including a closer look at the Meguiar's stand and the unique cars taking centre stage on display. Make sure you check back tomorrow for more!


text:
Nate Berkus Interior Designer Biography, Family, Life & More
Nate Berkus Interior Designer Bio
Name Nathan Jay Berkus (Nate Berkus)
Profession Interior Designer
Date of Birth September 17, 1971
Age 49 (As in 2020)
Height 5′ 9″ (1.75 m) (Approx)
Net Worth 18$ million dollars
Birth Place Orange County, California
Zodiac Sign/Sun Sign Virgo
Religion Jewish
Eye Colour Greenish
Hair Colour Dark Brown
1 Nate Berkus Interior Designer Bio
2 Nate Berkus Childhood
3 Nate Berkus Living
4 Education and Accomplishments
5 Nate Relationship Status
6 Nate Berkus Family
7 Nate Family Journey
8 Nate Berkus Hobbies
9 The Nate Berkus Show
10 Nate Berkus Reads
11 Nate Berkus Design
12 Nate and Jeremiah by Design
13 Nate Berkus Occasions
Nate Berkus Childhood
Nate mentions "If I think back, to the kid in my childhood bedroom hysterically crying like a boy. Knowing it would never happen. Being bullied, being terrified to get on the school bus because this huge guy I mean I was too small. When I was in elementary school and I remember just thinking like what I can't have. Am I supposed to get through this? But even in my darkest moments I just knew that it would get better.
Nate Berkus Living
He was born in Southern California. But he was raised in Minnetonka, Minnesota. Nate went through the Hopkins school district from kindergarten through high school and graduated from Hopkins High School in Minnetonka. He grew up largely in Minneapolis.
Current Living
Los Angeles – Enchanting Nate Berkus Home in L.A. where they now raise their two children, Poppy Brent Berkus, 3, and Oskar Brent Berkus, 6 months, that you can really feel that love. Yes, this house has all the grandeur and architectural beauty you'd expect. From the renowned celebrity designers, but it pulsates with love and energy that can literally feel as you walk through the front door. Their house feels like home.
Education and Accomplishments
Nate Berkus Senior Year at the prestigious Cushing Academy in Massachusetts
Nate Berkus Graduated from Lake Forest College in Illinois with a degree in French and Sociology. However, in 1994, Berkus graduated from Lake Forest College. It is a private liberal arts school 30 minutes north of Chicago. He earned a bachelor's degree in French and Sociology.
Chicago Social Magazine Design Director 2000
House Beautiful's Next Wave Design Talent 2003
Craine Business Magazine's 40 Under 40 To Watch 2003.
First Appearance on The Oprah Winfrey Show in 2002,
Featured Publications including Architectural Digest, House Beautiful, Vogue, InStyle, O, The Oprah Magazine, People, and Elle Decor
He is the author of two New York Times best-selling books: Home Rules and The Things That Matter. However, you probably know him best from his design shows, Burkes has also written two books: Home Rules: Transform the Place You Live into a Place You'll Love, released in 2005, and The Things That Matter, published in 2012. He's dabbled in film, too, executive producing the Oscar-winning movie The Help.
Nate Relationship Status
Sexual Orientation Gay
Affairs/ Boyfriends
His former partner, Fernando Bengoechea, was killed when the tsunami hit Sri Lanka in December 2004. The couple was vacationing there at the time. Nate Berkus and Fernando Bengoechea met for the first time on a photo-shoot for Oh at a home magazine that was in 2003.
Jeremiah Brent reveals their proposal story in an interview. He was asked some of the personal questions in an interview. However, to summarize many things were asked relating to Nate, daughter Poppy etc. The interesting part is Nate Berkus Wedding Proposal story of how Nate proposed Jeremiah to marry him.
Married. Nate married Jeremiah Brent, who is also an interior designer and TV personality. Brent and Berkus made history as the first same-sex couple to marry there, PEOPLE reported. Nate Berkus Wedding took place in May 2014 at the New York Public Library. The interior designer also remembers favorite Nate Berkus wedding memory of that day.
In a 2016 interview, Berkus credited Brent with being open and accepting of his relationship with Bengoechea. "I honor that story. Our daughter will know who he was; We have pictures of him in the home," Brent said.
Nate Berkus Family
Mother (Nancy Golden)
Nate's mother is designer Nancy Golden from the HGTV and DIY networks, and his dad co-founded the National Sports Collectors Convention. His mother received an emotional Nate Berkus tsunami call when he survived the deadliest tsunami back in 2004.
Father (Mike)
Mike co-founded the National Sports Collectors Convention
Siblings (Dave, Barry, Gunther, Josh, Eric, Matt Berkus)
Berkus is related to the venture capitalist Dave Berkus. Also, architect Barry Berkus, musician/artist Gunther Berkus, Josh Berkus of Software in the Public Interest. Finally, casino manager/author Eric David Berkus, and western states lawyer Matt Berkus.
Husband (Jeremiah Brent)
Nate Berkus Relationship with Jeremiah is simply warm-hearted. Here, they both were asked regarding their working relationship as a couple. However, they both Nate and Jeremiah had to respond differently. They both have completed the second season of their show on TLC which is called 'Nate and Jeremiah by Design'.
Children (Poppy, Oskar Brent Berkus)
The Brent-Berkus clan is now a party of four! Their daughter, Poppy Brent-Berkus, was born in March 2015 via a surrogate.
Nate Berkus Surrogacy – Poppy took part in the process all along. Nate Berkus surrogacy process along with Jeremiah Brent was wonderful. The couple tried their level best throughout the pregnancy process to provide many ceremonial experiences for Poppy. Thus she can feel excited and involved for Oskar's arrival.
Nate Family Journey
Nate Berkus and Jeremiah Brent started a family, the couple made the announcement via their respective Facebook pages. It's just become even more beautiful. However, we are happy to announce that we are expecting our first child. Nate surrogate born daughter Poppy Brent Berkus was about to be born. They added while we can't share much we can say that thanks to a surrogate. The support of those we love we will officially be a family in the spring of 2015.
However, In the March of 2018, Jeremiah Brent and Nate Berkus Son Oskar was born. "It is with so much love that we welcome Oskar Brent-Berkus to our family," Berkus wrote on Instagram. "We have waited for you, we already love you, and we as a family stand on the shoulders of so many people who have made it possible for families like ours to continue to grow." Recently Jeremiah Brent uploaded pictures of Oskar Brent Berkus Photoshoot with himself.
Nate Berkus Hobbies
Beautiful woven blankets from Mexico.
Fantastic colonial antiques from Cambodia.
Anything that is indigenous to that area.
Hand tooled leather.
Beads and glass.
The Nate Berkus Show
Audiences have followed Nate through his television shows. Including the daily, syndicated The Nate Berkus Show. In addition to, 2014's American Dream Builders on NBC, and his current hit show Nate & Jeremiah By Design, which had its second season on TLC. He is an artistic advisor for LG Studio. Nate also served as executive producer of the Oscar-winning film The Help. Nate's popular product lines include a home collection sold at Target and a fabric line at JOANN Fabric and Craft Stores.
Nate Berkus Reads
Every month from August 2017 until now Nate has been consistently updating his fans regarding his reading collection. In addition to he introduced his book recommendations by a new hashtag. #NateReads You can check out his previous set of books suggested by him in the past several months in the reverse order.
Nate Berkus December
Nate Berkus November
Reading September
Nate Berkus August
Entire Reads (July 2017-July 2018)
Interior designer Nate Berkus always take out time for the fans. He gives out design styling related Ideas to the fans through social media platforms. Nate Berkus goes live on Facebook and he answers design-related questions. Therefore, questions are asked by fans from all around the world. Nate is always fond of answering questions and helping fans to the best of his abilities when it comes to his Design.
You can check out the design related session in the links below.
Nate Berkus Design Styling
Nate Berkus Design Tips
In addition to, he took on Renovation related QnA, you can check that out as well.
Nate Berkus Target Renovations
Nate and Jeremiah by Design
He used to be a regular on Oprah's show. However, Jeremiah Brent has a design company on both coasts. They combine forces for the TLC show Nate and Jeremiah by Design. So, the two interior designers were in town this weekend checking out their new line of furniture over at living spaces. We found out while their interior design styles are shown in TV shows, movies, magazines, online. They're kind of down-to-earth guys. Most of us can't afford a designer and probably aren't even sure how to arrange our living room furniture.
Nate and Jeremiah by Design Season 3 – A surprise for Nate and Jeremiah fans. A few days ago Jeremiah posted a video on social media regarding a surprise. Jeremiah hinted that it had them years in the making. Fans from all around the world went guessing what the couple is up to.
Nate Berkus Occasions
Nate Berkus Halloween – Nate and Jeremiah posted Halloween pictures and some small chunk of videos on the internet. Letting the fans know how the interior designers are celebrating their Halloween this year.
Nate Berkus tsunami Plea – In addition to a tsunami incident, it reminds Nate Berkus of a flashback. Famous interior designer Nate Berkus has previously survived 2004 tsunami while his former partner Fernando Bengoechea is presumed dead in that incident. As an example, whenever a tsunami incident occurs around the globe, it gives him the opportunity to shout out for help.

redpajama_set_name: RedPajamaCommonCrawl


text:
Media and Internet company IAC is buying Angie's List
Reporting from New York —
Media and Internet company IAC, or InterActiveCorp, on Monday said it is buying Angie's List Inc. with the aim of melding the consumer reviews company with its HomeAdvisor business and creating a new publicly traded enterprise.
The combined company will be called ANGI Homeservices Inc. and will keep both the Angie's List and HomeAdvisor brands.
Founded by Angie Hicks in 1995, Angie's List lets users research, shop for and rate local plumbers, home cleaners and other service providers. HomeAdvisor.com offers resources for home repair and improvement projects, such as helping find the average project cost across the country and finding professionals for the work.
It's a merger IAC first proposed in 2015, which Angie's List rejected, saying the per-share offer of $8.75 was too low. But sales at Angie's List have been sliding, and in November it said it was exploring "strategic alternatives."
Under the deal announced Monday, Angie's List stockholders will get either one share of ANGI Homeservices Inc., or $8.50 in cash, for each share of Angie's List they own. The cash portion of the deal is capped at $130 million.
At $8.50 a share, the deal values Angie's list at about $505 million.
New York-based IAC, which is controlled by media mogul Barry Diller, will own between 87% and 90% of ANGI Homeservices Inc., depending on how many Angie's List shareholders take cash instead of stock in the combined company.
HomeAdvisor CEO Chris Terrill will become chief executive of ANGI Homeservices Inc., which will be based at HomeAdvisor's headquarters in Golden, Colo.
Shares in Indianapolis-based Angie's List surged more than 42% to $8.39 in extended trading after the deal was announced.
Stocks close up, lifted by tech companies and banks
Twitter teams up with Bloomberg on 24/7 streaming news; stock jumps
Tribune Media's shares jump 6% on reports Fox and Blackstone want to buy it


text:
\section{Introduction}

\label{sect-intro}

The assembly of multifunctional units into linear or branched architectures is
a key ingredient of copolymerisation. In turn, the properties of copolymers
depend crucially on how these units are arranged, as in alternating, random or
block copolymers \cite{Hamley:1998}. Examples are manifold, and we mention
just a few: the stacking transition of single-strand DNA \cite{ssDNA}; the
nature of the de-mixing instabilities in both coil-coil \cite{Teixeira:2000}
and coil-rod \cite{Teixeira:2007} polymer blends undergoing polycondensation
reactions; the ability of urethane-urea elastomers to exhibit strain-induced
periodic textures \cite{bookchapter}; the self-healing nature of
poly(methyl methacrylate)/n-butyl acrylate over a narrow range of compositions
\cite{Urban:2018}; and the association of DNA duplexes by stacking
interactions~\cite{stacking1,stacking2,stacking3}.

The actual sequence of building blocks on individual copolymer molecules is
experimentally inaccessible and must be inferred indirectly, e.g., from the
comonomer ratios, or from details of the synthesis method employed. It would
be most desirable to have a predictive theory for this information that might
be used as input to theories for macroscopic properties, e.g., elastic or
rheological. Such a theory could be readily validated by computer simulations
of copolymerisation. From a more practical point of view, this approach would
have the added bonus of enabling the `reverse engineering' of desired polymers:
by elucidating which properties of building blocks (e.g., size, interaction
energies) produce which architectures, polymer synthesis could be more
effectively directed towards specific outcomes.

In this paper  we consider one prime application of the above: the assembly
of DNA chains from two types of monomers, each consisting of one
short nucleotide duplex. Besides its biological
relevance, this has two advantages with respect to testing our theory: first,
it is the simplest case of linear aggregation; second, by tuning the model
parameters we can adjust the interaction energies between different building
blocks and thus generate a large variety of chain architectures, allowing for
a more thorough and detailed comparison between simulation and theoretical
predictions. We start in
section \ref{sect-theory} by expounding a very simple theory of linear
aggregation that forgoes most microscopic detail and treats the bonding of
polymerising units as reversible chemical reactions, governed by reaction
constants.
The reaction constants are taken either from
Santalucia's treatment of the nearest-neighbour model for DNA
\cite{santalucia1998unified,bommarito2000thermodynamic}, or from
Wertheim's thermodynamic perturbation theory of association for spherical
patchy particles \cite{Wertheim:1984a,Wertheim:1984b}. Then in section
\ref{sect-model} we describe the microscopic DNA model used in our simulations.
Results are presented in section \ref{sect-results}, and conclusions drawn in
section \ref{sect-conclusions}.

\section{Theory}

\label{sect-theory}

\subsection{A minimal description of linear aggregation}

\label{subsect-linear}

Our system consists of a binary mixture of $N_A$ particles of species $A$,
each decorated with two bonding sites (`patches') of type $A$, and $N_B$
particles of species $B$, each decorated with two bonding sites of type
$B$, in a volume $V$. The total number of particles is thus $N=N_A+N_B$,
and their mole fractions are $x_A\equiv N_A/N$ and $x_B\equiv N_B/N=1-x_A$.

Each of the two sites can participate in at most one bond to another site, so a
given particle (of species $A$ or $B$) can bond to at most two other particles
(linear aggregation). We shall regard the formation of an $\alpha\beta$ bond
as a reversible chemical reaction between an unreacted  site of type $\alpha$
and one of type $\beta$ ($\alpha,\beta=A,B$). If we now assume that both sites
and bonds behave as ideal gases, then the equilibrium constant for this
reaction is given by \cite{Atkins:2014}
\begin{equation}
\label{eq:Kab}
K_{\alpha\beta}=\frac{P_{\alpha\beta}^*}{P_\alpha^*P^*_\beta}
\equiv\exp\left(-\beta\Delta G_{\alpha\beta}\right),
\end{equation}
where $P^*_k$ is the ratio of the partial pressure of sites or bonds
of type $k$ ($k=\alpha$, $\beta$ or $\alpha\beta$) at equilibrium to some
reference pressure $P_{ref}$, and $\Delta G_{\alpha\beta}$ is the change in Gibbs
free energy on forming an $\alpha\beta$ bond. Because we are assuming that all
sites and bonds $k$ behave as ideal gases, we have
\begin{eqnarray}
\label{eq:pressure1}
P^*_{\alpha\beta}&=&\frac{N_{\alpha\beta}k_BT}{P_{ref}V}, \\
\label{eq:pressure2}
P^*_{\alpha}&=&\frac{M_{\overline{\alpha}}k_BT}{P_{ref}V},
\end{eqnarray}
where $N_{\alpha\beta}$ is the number of $\alpha\beta$ bonds, $M_{\overline{\alpha}}$
is the number of unreacted sites of type $\alpha$,
$k_B$ is Boltzmann's constant and $T$ is the temperature.
Using equations (\ref{eq:pressure1}) and (\ref{eq:pressure2}), equation
(\ref{eq:Kab}) can be rewritten as
\begin{equation}
\label{eq:Kab2}
K_{\alpha\beta}=\frac{N_{\alpha\beta}}{M_{\overline{\alpha}} M_{\overline{\beta}}}
\frac{P_{ref}V}{k_BT}.
\end{equation}
If we further assume that $P_{ref}$ is the pressure of the system when no
``chemical reaction'' has occurred (i.e., when there are no aggregates but the
same total number of sites is present) then $P_{ref} = 2N k_B T/V$ (recall there
are two sites per particle), whence
\begin{equation}
\label{eq:Kab3}
K_{\alpha\beta}=2N\frac{N_{\alpha\beta}}{M_{\overline{\alpha}} M_{\overline{\beta}}}.
\end{equation}
We note that this result can be given a microscopic interpretation: in terms of
the partition functions of species $\alpha$, $Q_\alpha$, and of $\alpha\beta$
dimers $Q_{\alpha\beta}$, the condition for chemical equilibrium is
\cite{Hill:1986,RF}
\begin{equation}
	\label{eq:equilibrium}
	\frac{N_{\alpha\beta}}{M_{\overline\alpha}M_{\overline\beta}} =
	\frac{Q_{\alpha\beta}}{Q_\alpha Q_\beta}=\frac{K_{\alpha\beta}}{2N}
        =\frac{\exp\left(-\beta\Delta G_{\alpha\beta}\right)}{2N},
\end{equation}
i.e., the partition functions of particles and bonds are subsumed in the
equilibrium constants, for which we need some prescription. We shall come
back to this point later.

From the above we can now derive the laws of mass action for the three
reactions: $\overline{A}+\overline{A}\rightleftharpoons AA$,
$\overline{B}+\overline{B}\rightleftharpoons BB$ and
$\overline{A}+\overline{B}\rightleftharpoons AB$,
where the overline denotes an unreacted site. Using the constraints
\begin{eqnarray}
\label{eq:totA}
2N_A=2N_{AA} + N_{AB} + M_{\overline{A}}, \\
\label{eq:totB}
2N_B=2N_{BB} + N_{AB} + M_{\overline{B}},
\end{eqnarray}
and the usual definitions for the fractions of unbonded $A$ and $B$ sites,
\begin{equation}
\label{eq:XAXB}
X_\alpha=\frac{M_{\overline{\alpha}}}{2N_\alpha},
\end{equation}
we arrive at the following laws of mass action:
\begin{eqnarray}
\label{eq:lma01}
1-X_A&=&2x_AK_{AA}X_A^2+2x_BK_{AB}X_AX_B, \\
\label{eq:lma02}
1-X_B&=&2x_BK_{BB}X_B^2+2x_AK_{AB}X_AX_B,
\end{eqnarray}
Note that in the above expressions we are assuming that no rings are formed.
In the thermodynamic limit ($N\to\infty$, $V\to\infty$), $p_\alpha=1-X_\alpha$
is the probability that a site of type $\alpha$ has reacted (i.e., is bonded
to another site). Noting that the total number of sites of type $\alpha$ that
participate in $\alpha\beta$ bonds is $(1+\delta_{\alpha_\beta})N_{\alpha\beta}$
(with $\delta_{\alpha_\beta}$ the Kronecker delta) and the total number of sites
of type $\alpha$ is $2N_\alpha$, then the probability of bonding a site of type
$\alpha$ to one of type $\beta$ is \cite{Tavares:2010}.
\begin{equation}
\label{eqpalphabeta}
p_{\alpha\beta}=(1+\delta_{\alpha_\beta})\frac{N_{\alpha\beta}}{2N_\alpha}.
\end{equation}
(Notice that, although $N_{\alpha\beta} = N_{\beta\alpha}$ always holds,
if $N_\alpha \neq N_\beta$ then $p_{\alpha\beta} \neq p_{\beta\alpha}$.)
From these probabilities, which can be obtained by solving the laws of mass
action, equations (\ref{eq:lma01}) and (\ref{eq:lma02}), we can compute a
number of interesting structural quantities. In particular, we shall derive
the statistics of `blocks', i.e., the probabilities of assembling sequences
of contiguous identical bonds (`blocks') of length $\ell_{\alpha\beta}$, defined
as the number of $\alpha\beta$ bonds in the sequence (block).

Let us consider first blocks of identical particles. To make an $A$
block of length $\ell_{AA}$, one starts with a particle of species $A$
that has one $A$ site not bonded to another $A$ site: there are $N_A(1-p_{AA})$
such particles (notice that an $A$ site that is not bonded to another $A$ site
could be either unbonded to any site, or bonded to a $B$ site). Then one needs
to make $\ell_{AA}$ bonds, each with probability $p_{AA}$, which gives a factor
of $p_{AA}^{\ell_{AA}}$. Finally, the block ends with an $A$ site that is not
bonded to any other $A$ site, hence another factor of $(1-p_{AA})$. It follows
that the number of $A$ blocks of length $\ell_{AA}$ is
\begin{equation}
\label{eq:nAA}
n(\ell_{AA})=N_Ap_{AA}^{\ell_{AA}}\left(1-p_{AA}\right)^2.
\end{equation}
Likewise, the number of $B$ blocks of length $\ell_{BB}$ is
\begin{equation}
\label{eq:nBB}
n(\ell_{BB})=N_Bp_{BB}^{\ell_{BB}}\left(1-p_{BB}\right)^2.
\end{equation}

Now consider $AB$ blocks of block size $\ell_{AB}$, i.e., alternating sequences
of $A$ and $B$ particles. Two cases must be distinguished: blocks with either
$A$ or $B$ sites at both ends have odd $\ell_{AB}$, whereas blocks with an $A$
site at one end and a $B$ site at the other end have even  $\ell_{AB}$.
The number of $AB$ blocks with odd $\ell_{AB}$ is
\begin{equation}
\label{nlABodd}
\begin{split}
n(\ell_{AB},{\rm{odd}}) =&  N_A\left(1-p_{AB}\right)
p_{AB}^{(\ell_{AB}+1)/2}p_{BA}^{(\ell_{AB}-1)/2}\left(1-p_{BA}\right)\\
&
+N_B\left(1-p_{BA}\right)p_{BA}^{(\ell_{AB}+1)/2}
p_{AB}^{(\ell_{AB}-1)/2}\left(1-p_{AB}\right).
\end{split}
\end{equation}
The first term on the right-hand side (rhs) of this equation is derived as
follows: if an $AB$ block starts with an $A$ particle, then one of its $A$
sites is not bonded to an $B$ site, which gives the factor
$N_A\left(1-p_{AB}\right)$;
then, there follow $\left(\ell_{AB}+1\right)/2$ $AB$ bonds alternating with
$\left(\ell_{AB}-1\right)/2$ $BA$ bonds, which gives the factor
$p_{AB}^{(\ell_{AB}+1)/2}p_{BA}^{(\ell_{AB}-1)/2}$; finally, the block ends
with a $B$ site not connected to an $A$ site, which gives the factor
$\left(1-p_{BA}\right)$. The second term is obtained by just exchanging $A$
and $B$ in the preceding argument: it corresponds to counting the $AB$ and
$BA$ bonds for an $AB$ block that starts with a $B$ particle and ends with an
$A$ particle. Equation (\ref{nlABodd}) can be simplified using the definitions
of $p_{AB}$ and $p_{BA}$, with the result
\begin{equation}
\label{nlabodd2}
n(\ell_{AB},{\rm{odd}}) = 2N_A^{1/2} N_B^{1/2}
\left(1-p_{AB}\right)\left(1-p_{BA}\right) p_{AB}^{\ell_{AB}/2}p_{BA}^{\ell_{AB}/2}.
\end{equation}

By the same reasoning, the number of $AB$ blocks with even $\ell_{AB}$ is
\begin{equation}
\label{nlABeven}
\begin{split}
n(\ell_{AB},{\rm{even}})= &N_A\left(1-p_{AB}\right)
\left(p_{AB}p_{BA}\right)^{\ell_{AB}/2}\left(1-p_{AB}\right) +\\
&+N_B\left(1-p_{BA}\right)\left(p_{AB}p_{BA}\right)^{\ell_{AB}/2}
\left(1-p_{BA}\right).
\end{split}
\end{equation}
We reiterate that, in order to fulfil symmetry under sequence inversion,
i.e., the requirement that the identity
of a block should be independent of the order in which its sequence
is read, equations (\ref{nlABodd}) and (\ref{nlABeven}) include a contribution
from both: $AB\ldots AB$ and $BA\ldots BA$ sequences, for $\ell_{AB}$ odd;
and from $AB\ldots BA$ and $BA\ldots AB$ sequences, for $\ell_{AB}$ even.

The mean block lengths can now be calculated. For $AA$ and $BB$ blocks, we have
\begin{eqnarray}
\label{eq:lAav}
\langle \ell_{AA} \rangle &=&\frac{1}{1-p_{AA}}, \\
\label{eq:lBav}
\langle \ell_{BB} \rangle &=&\frac{1}{1-p_{BB}}.
\end{eqnarray}
Notice that these expressions are general, in the sense that they apply even
when $N_A\ne N_B$. The mean length of $AB$ blocks is
\begin{eqnarray}
\langle \ell_{AB} \rangle &=& \frac{ \sum_{i=1}^\infty
\left[(2i-1)n(2i-1,{\rm{odd}})+2i\: n(2i,{\rm{even}})\right]}
{ \sum_{i=1}^\infty \left[n(2i-1,{\rm{odd}})+n(2i,{\rm{even}})\right]}\nonumber\\
\mbox{} &=& \frac{1}{1-p_{AB}p_{BA}}\frac{1+p_{AB}p_{BA}+F(p_{AB},p_{BA})}
{1+\frac{1}{2}F(p_{AB},p_{BA})},
\label{eq:lABav}
\end{eqnarray}
where
\begin{equation}
\label{Fxy}
F(x,y)=\frac{x(1-y)^2+y(1-x)^2}{(1-x)(1-y)}.
\end{equation}
It is readily seen that $\langle \ell_{AA}\rangle $ and $\langle\ell_{BB}\rangle$
are functions of, respectively, $p_{AA}$ and $p_{BB}$ only, whereas
$\langle\ell_{AB}\rangle$  is a function of $p_{AB}$ and $p_{BA}$ only.
It follows that results do not depend on whether these
blocks are isolated or part of longer chains. Further note that, by
construction, the minimum length of an $\alpha\beta$ block is 1, when
$p_{\alpha\beta}\to 0$: this is because, in this limit, $N_{\alpha\beta} \to 0$
and both the number of $\alpha\beta$ blocks and their length $\to 0$,
but the ratio of these two quantities $\to 1$.

If $N_A=N_B$, in which case $p_{AB}=p_{BA}$, equation (\ref{eq:lABav})
simplifies to
\begin{equation}
\langle \ell_{AB} \rangle = \frac{1}{1-p_{AB}}.
\end{equation}
Furthermore, equations (\ref{nlABodd}) and (\ref{nlABeven}) become
identical, leading to
\begin{equation}
n(\ell_{AB})=2N_A\left(1-p_{AB}\right)^2p_{AB}^{\ell_{AB}}.
\end{equation}

\subsection{Extension to multiple species}

The theory of linear aggregation of the preceding section can be
straightforwardly extended to the case where we have $n$ distinct chemical
species $\alpha = S_1, S_2, \ldots, S_n$,
each decorated with two identical bonding sites. If, as before,
$N_\alpha$ is the number of particles of species $\alpha$, the total number
of particles in the system will be $N = \sum_\alpha N_\alpha$, and their mole
fractions $x_\alpha = N_\alpha /N$. Therefore we have a set of $n(n+1)/2$ coupled
chemical reactions:
\begin{equation}
	\overline{\alpha} + \overline{\beta} \rightleftharpoons \alpha\beta,
	\qquad \alpha, \beta = S_1,\ldots,S_n,
\end{equation}
subject to the $n$ constraints
\begin{equation}
	2N_\alpha = M_{\overline\alpha} + 2N_{\alpha\alpha} +
	\sum_{\beta\neq\alpha} N_{\alpha\beta},
	\qquad \alpha = S_1,\ldots,S_n.
\end{equation}
In the ideal gas of clusters approximation, the condition of chemical
equilibrium between any pair of species $\alpha$ and $\beta$ is given by
(\ref{eq:equilibrium}) and similarly the equilibrium constant of each reaction
by (\ref{eq:Kab}). The $n$ laws of mass action are obtained as
\begin{equation}
\label{eq:lmagen}
	1-X_\alpha = \sum_{\beta} \left(1+\delta_{\alpha\beta}\right)
	x_\beta X_\alpha X_\beta K_{\alpha\beta},
\end{equation}
where $X_\alpha = M_{\overline\alpha}/2N_\alpha$.
Accordingly, the results in block statistics could be extended to account
for the assembly of more complex architectures.

As mentioned above, we require some prescription for finding the equilibrium
contants $K_{\alpha\beta}$, and thence the probabilities $p_\alpha$ and
$p_{\alpha\beta}$. For DNA, perhaps the simplest way is to compute them using the
second equality in equation (\ref{eq:Kab}) with $\Delta G_{\alpha\beta}$ given
by Santalucia for the nearest-neighbour model
\cite{santalucia1998unified,bommarito2000thermodynamic}. Alternatively, one
can map a microscopic, off-lattice theory of self-assembly onto the above
minimal description. This we do in the next section; a similar approach
has been proposed by Reinhardt and Frenkel \cite{RF}.

\subsection{Wertheim's thermodynamic perturbation theory}

\label{subsect-Wertheim}

Wertheim's thermodynamic perturbation theory (TPT) is a microsopic theory
for the self-assembly of particles interacting via strong, short-ranged
attractions \cite{Wertheim:1984a,Wertheim:1984b}. It has found novel
applications in the description of the phase behaviour of patchy colloidal
particles~\cite{bianchi,russo,starr}. As in \cite{LocRov},
we rather bluntly approximate the solution of DNA sequences as a binary
mixture of $N_A$ and $N_B$ equisized hard spheres (HSs) of diameter $\sigma$,
contained in a volume $V$; the total number density is thus
$\rho=(N_A+N_B)/V\equiv N/V$. The solvent is not explicitly considered.
Both species are divalent: particles of species $A$ are decorated with two
attractive sites, or `patches', of type $A$, and particles of type $B$ are
decorated with two patches of type $B$: these represent the single strands
at the end of the DNA sequences. We make the usual assumption that the patches
are distributed over the spheres' surfaces in such a way that each patch can
only take part in at most one bond, which is a short-ranged attractive
interaction between two patches, as is appropriate for DNA bases. We take
these inter-patch attractions to be square wells of depth $\epsilon_{\alpha\beta}$
and range chosen such that the volume available to an $\alpha\beta$ bond is
$v_b^{\alpha\beta}$ ($\alpha,\beta=A,B$).

Following \cite{Heras2} the bonding probabilities $p_{\alpha\beta}$ are given by
\begin{eqnarray}
\label{eq:pAA}
p_{AA}&=&2\xi x_A\Delta_{AA}X_A^2, \\
\label{eq:pBB}
p_{BB}&=&2\xi x_B\Delta_{BB}X_B^2, \\
\label{eq:pAB}
p_{AB}&=&2\xi x_B\Delta_{AB}X_AX_B, \\
\label{eq:pBA}
p_{BA}&=&2\xi x_A\Delta_{AB}X_AX_B,
\end{eqnarray}
where $\xi=\rho v_{HS}$, with $v_{HS}=\pi\sigma^3/6$ the volume of a HS, is the
(total) packing fraction, $x_\alpha=N_\alpha/N$ is the mole fraction of component
$\alpha$ ($\alpha=A,B$), and $\Delta_{\alpha\beta}$ are the bond partition
functions. In the low-density, strong-interaction limit, which as we shall see
is appropriate to our simulations, we have
\begin{equation}
\label{eq:Delta}
\Delta_{\alpha\beta}\approx{v_b^{\alpha\beta}\over v_S}\exp(\beta\epsilon_{\alpha\beta}),
\end{equation}
In equations (\ref{eq:pAA})--(\ref{eq:pBA}), $X_\alpha$, the fractions of
unbonded sites of type $\alpha=A,B$, are given by the following laws of
mass action:
\begin{eqnarray}
\label{eq:lma1}
1-X_A&=&2\xi x_B\Delta_{AB}X_AX_B+2\xi x_A\Delta_{AA}X_A^2, \\
\label{eq:lma2}
1-X_B&=&2\xi x_B\Delta_{BB}X_B^2+2\xi x_A\Delta_{AB}X_AX_B.
\end{eqnarray}
Comparing equations (\ref{eq:lma01}) and (\ref{eq:lma1}), (\ref{eq:lma02})
and (\ref{eq:lma2}), and further noting that the fraction of sites of type
$\alpha$ is the same as the mole fraction of particles of species $\alpha$,
we conclude that the reaction constants in our minimal description are very
simply related to the bond partition functions:
\begin{equation}
\label{eq:Kab4}
K_{\alpha\beta}=\xi\Delta_{\alpha\beta}.
\end{equation}

How can we now relate the parameters of Wertheim's TPT to those of Santalucia?
Start by noting that, from equations (\ref{eq:Kab}),(\ref{eq:Delta}) and
(\ref{eq:Kab4}), we have
\begin{equation}
\label{eq:DeltaG}
\beta\Delta G_{\alpha\beta}=-\log\left(\xi\Delta_{\alpha\beta}\right)
=-\log\left(\rho v_b^{\alpha\beta} \right)-\beta\epsilon_{\alpha\beta}.
\end{equation}
Recalling that $\Delta G_{\alpha\beta}=\Delta H_{\alpha\beta}-T\Delta S_{\alpha\beta}$,
where $H_{\alpha\beta}$ and $S_{\alpha\beta}$ are, respectively, the enthalpy and
entropy of an $\alpha\beta$ bond, we can identify
\begin{equation}
\label{eq:deltaH}
\Delta H_{\alpha\beta}=-\epsilon_{\alpha\beta} \qquad , \qquad
\Delta S_{\alpha\beta}=\log\left(\rho v_b^{\alpha\beta} \right),
\end{equation}
i.e., the change in enthalpy is related to the bond strength, and the change
in entropy to the volume available to the bond. In actual systems it is often
the case that the pressure and volume vary very little, and the change in
enthalpy can thus be equated to a change in internal energy
\cite{Sciortino:2007}.

Wertheim's theory thus provides an inexpensive alternative description of the
self-assembly statistics in block copolymer systems, on the basis of very
simple model -- patchy particles --  whose interaction parameters can be
readily related to hybridisation enthalpies and entropies. It has exactly the
same structure as the minimal theory of linear aggregation of the preceding
section, so the same accuracy can be expected.

\section{Model for DNA}

\label{sect-model}

We describe DNA using the oxDNA model \cite{OxDNA1,OxDNA2}. This is a
coarse-grained model with implicit solvent, which has been shown to capture the
basic thermodynamics, as well as the essential structural properties, of DNA.
It consists of rigid nucleotides, interacting via pairwise interactions that
comprise non-linear elastic, stacking, cross-stacking, excluded-volume and
hydrogen bonding contributions; see \cite{OxDNA2} for details.

The system we investigate is a binary mixture
of DNA nanoparticles~\cite{ns1,ns2}.
Each `particle' is made up of a complementary double helix core
${\bf X}$ decorated with identical single strands, of types $a$ or $b$,
at either end, i.e., the two particle species are $A=a{\bf X}a$ and
$B=b{\bf X}b$. The binding enthalpy of the
$a\!-\!a$, $b\!-\!b$ and $a\!-\!b$ pairings
can be tuned via a judicious choice of the sticky-end binding sequences.
In what follows, we shall take $A$ ($B$) to refer interchangeably
to either a single strand of type $a$ ($b$) or a particle of species $A$ ($B$).
To break the symmetry of the model, we want to favour $BB$ bonds over $AA$ or
$AB$ bonds. We thus need to find pairs of short self-complementary DNA
sequences $A$ and $B$ that can bind to each other. Preliminary calculations
using Wertheim's theory suggest rich behaviour is realised if their
hybridisation enthalpies satisfy the conditions
\begin{equation}
\label{eq:enthalpies}
\frac{\Delta H_{AB}}{\Delta H_{AA}} \simeq 1, \quad
\frac{\Delta H_{BB}}{\Delta H_{AA}} \simeq 1.25.
\end{equation}
No condition is set on their hybridisation entropies. The nearest-neighbour
model of SantaLucia \cite{santalucia1998unified} allows us to compute these
quantities for any given sequence:
the values of $\Delta H$ and $\Delta S$ can be assumed to be
temperature-independent at least in a `narrow' range around $T=\SI{310}{\K}$.
In order to fulfil conditions (\ref{eq:enthalpies}), $B$ is chosen to be the
same as $A$ with an extra pair of complementary nucleotides, one at each end,
so that $B$ will bind to $B$ with greater energy than $A$ to $A$, but will
still be able to bind to $A$ with roughly the same energy as $A$ to $A$.
The dangling ends in an $AB$ bond will actually provide an extra contribution,
usually increasing stability of $AB$ with respect to $AA$, as evaluated in
\cite{bommarito2000thermodynamic}; without this stabilizing mechanism there
would be no reason for $A$ and $B$ to form this mixed complex instead of only
$AA$ and $BB$. This also implies that the condition
$\frac{\Delta H_{AB}}{\Delta H_{AA}} \simeq 1$ is not really attainable, so we
should just look for this ratio to be as close as possible to unity. Two
sequences that come close to these target values are $A$=CGATCG and
$B$=TCGATCGA, whose hybridisation enthalpies and entropies are reported in
Table~\ref{table1}. Note that $A$ can bind to $A$
(being `palindromic') with six bases, $B$ can bind to $B$ with eight bases,
and $A$ can bind to $B$ with six bases. A cartoon of a particle is shown in
figure \ref{fig1}.

\section{Results}

\label{sect-results}

We ran constant-volume molecular dynamics (MD) simulations starting with
$N_A=N_B=200$ bifunctional particles of types $a{\bf X}a$ and $b{\bf X}b$,
for a total of 800 sticky ends on 400 particles. The resulting concentration
of single strands of each species in solution is $c \approx 392 \,\mu{\rm M}$.
We mimicked (recall there is no explicit solvent) an
aqueous solution of salt concentration $[\ce{Na+}]=\SI{0.4}{\molar}$, at
temperatures in the range $[40,58]\si{\celsius}$, where binding is expected to
take place and equilibration can be achieved with the available computational
resources.

From the simulation, we estimate the number of $A$ patches unbonded, bonded
with $A$ ($N_{AA}$) and bonded with $B$ ($N_{AB}$). Similar quantities are
calculated for $B$ patches. Using the relations previously introduced we
can then estimate $p_{AA} \equiv N_{AA}/N_A$, $p_{BB} \equiv N_{BB}/N_B$ and
$p_{AB} \equiv \frac{N_{AB}}{N_A}$, as well as $X_{A}$ and $X_{B}$.

The resulting probabilities are shown in figure \ref{fig2} as symbols;
the curves are the theory predictions computed
as explained below. The most difficult part of the
simulation is to `equilibrate' the $BB$ bonds, which, being composed
of more bases, are stronger and rarely break. The next-stronger bonds are $AB$
and $AA$, respectively. However, since forming $AB$ bonds would decrease the
number of $BB$ bonds, the system as a whole prefers to form more $AA$ bonds
than $AB$ bonds, in order to free $B$ patches for the most favourable $BB$
bonds.

From $ p_{AA}$, $p_{BB}$ and $p_{AB}$ we can then predict the chain length
distribution $P(n)$, where $n$ is the number of particles in the chain.
Let $s$ be a sequence of bonded monomers ($A$ or $B$ particles); the
probability of observing that sequence is
\begin{equation}
\label{prob}
	P(s) = \qty( 1-p_A )^{m_{\overline{A}}}\qty( 1-p_B )^{m_{\overline{B}}}
p_{AB}^{n_{AB}} p_{BA}^{n_{BA}} p_{AA}^{n_{AA}} p_{BB}^{n_{BB}} ,
\end{equation}
where $m_{\overline\alpha}$ is the number of free ends of type $\alpha$ and
$n_{\alpha\beta}$ is the number of sites of type $\alpha$ bonded to sites of
type $\beta$ (with the constraints $m_{\overline{A}}+m_{\overline{B}}=2$,
$n_{AA} + n_{AB} +  n_{BB}= n-1$). Then the probability $P(n)$ of observing a
cluster (literally a linear chain) of length $n$) is found by summing $P(s)$
over all possible sequences of $n$ monomers:
\begin{equation}
\label{eqPofn}
P(n)=\sum_{s=1}^{2^n} P(s).
\end{equation}
Figure \ref{fig3} compares theoretical predictions and simulation data for the
chain length distribution at all temperatures studied.

To evaluate $\Delta G_{\alpha\beta}$  we first combine equations (\ref{eq:Kab}),
(\ref{eq:pAA})--(\ref{eq:pAB}) and (\ref{eq:Kab4}) to obtain, for $x_A=x_B=0.5$,
\begin{equation}
\label{boundfractions}
p_{\alpha\beta}=X_\alpha X_\beta\exp\left(-\beta\Delta G_{\alpha\beta}\right).
\end{equation}
Equations (\ref{boundfractions}) can now be solved
using the data in figure \ref{fig2}, at each $T$. Results are plotted
in figure \ref{fig5}. In all cases, a linear dependence of
$\Delta G_{\alpha\beta}$ on $T$ is observed. The slope and intercept provide
the best-fit values for $\Delta H_{\alpha\beta}$ and $\Delta S_{\alpha\beta}$,
which can then be used backwards to predict the bond probabilities. These
predictions are shown as solid lines in figure \ref{fig2}.

Table \ref{table2} compares the best-fit values of $\Delta H_{\alpha\beta}$ and
$\Delta S_{\alpha\beta}$ with the predictions of the SantaLucia model. Though not
excellent, agreement is reasonable, considering that the oxDNA model is a
parametrisation based on SantaLucia estimates for the melting temperature.
Specifically, oxDNA predictions for the melting temperatures have been found
to deviate on average \SI{1.4}{\celsius} from those of SantaLucia
\cite{Sulc:2012}.

Finally, figure \ref{fig6} plots the mean block lengths
$\langle \ell_{\alpha\beta}\rangle$, {\it vs} either temperature
(figure \ref{fig6}a) or bond probability $p_{\alpha\beta}$ (figure \ref{fig6}b).
For our choice of parameters, both $AA$ and $AB$ blocks are very short and
the simulation data are very noisy; agreement between theory and simulation is
encouraging for the longer $BB$ blocks.

\section{Conclusions}

\label{sect-conclusions}

We have proposed a minimal theoretical framework for the assembly of linear
block copolymers. This makes very few assumptions on the nature of the
monomers, namely: (i) assembly is assimilated to reversible chemical reactions
between short-ranged bonding sites; (ii) each site can participate in at most
one bond; and (iii) the overall concentration is low enough that sites and
bonds behave as ideal gases. The theory requires as inputs the reaction
constants for the polymerisation reactions. Importantly, these can be
derived from theories that incorporate only very limited detail of the
actual molecular processes.

The theory was tested against simulation results for the assembly of DNA chains
from two types of short duplexes, as described by the oxDNA model, using
reaction constants calculated from Santalucia's theory of a lattice model
of DNA. This was found to reproduce the equilibrium block size distributions,
mean block sizes, and fractions of unreacted monomers fairly well.

The theory is easily generalised to any number of associating particle species
in any proportion. In our view it has the potential to become a useful tool
to predict or reverse-engineer the architectures of multi-block copolymers or
polycolloids, and even provide some insight into the kinetics of association.

\section*{Conflicts of interest}

There are no conflicts to declare.

\begin{acknowledgments}

R. F. and F. S. acknowledge support from MIUR PRIN 2017 (Project 2017Z55KCW).
J. M. T. and P. I. C. T. acknowledge financial support from the Portuguese
Foundation for Science and Technology (FCT) under Contracts nos.\
UIDB/00618/2020 and UIDP/00618/2020.

\end{acknowledgments}

redpajama_set_name: RedPajamaArXiv


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AT&T to pay $60 million FTC settlement for 'bait-and-switch' unlimited data plan
By Allison Matyus November 5, 2019
The Federal Trade Commission (FTC) has ordered AT&T to pay $60 million in a settlement regarding unlimited data plans and reduced data speeds.
The FTC announced the settlement on Tuesday, November 5, which is a result of a complaint from 2014. The complaint alleges that AT&T didn't fully disclose its policy to its customers with unlimited data plans that data speeds slowed down after a certain amount of data use. The FTC said that more than 3.5 million customers were affected.
The FTC voted 4-0-1 on the settlement. Commissioner Rohit Chopra issued a statement regarding the settlement, saying that "cheating is not competing."
"As detailed in the Commission's complaint, AT&T wanted the rewards without the risks, so it turned its offer of an 'unlimited' data plan into a bait-and-switch scam that victimized millions of Americans," reads Chopra's statement. "Subscribers were lured in with promises of unlimited data service for a fixed fee, trapped into multiple years of service by punitive termination fees, and then forced to switch to a more expensive tiered plan with overage fees to actually receive the unlimited data they were promised."
An AT&T spokesperson told Digital Trends, "We couldn't disagree more with Commissioner Chopra's baseless characterization of the case. None of his allegations were ever proved in court. We were fully prepared to defend ourselves, but decided settling was in the best interests of consumers."
As part of the settlement, AT&T is now required to disclose all restrictions of their plans "prominently and clearly."
"AT&T promised unlimited data — without qualification — and failed to deliver on that promise," Andrew Smith, director of the FTC's Bureau of Consumer Protection, said in Tuesday's press release. "While it seems obvious, it bears repeating that Internet providers must tell people about any restrictions on the speed or amount of data promised."
AT&T's $60 million penalty will go toward refunding current and former customers that signed up for unlimited data plans before 2011. Current customers will receive an automatic credit to their bills and previous customers will receive checks. Customers will not have to submit a claim for their refund.
"Even though it has been years since we applied this network management tool in the way described by the FTC, we believe this is in the best interests of consumers," the AT&T spokesperson said.
AT&T announced three new unlimited data plans last week offering unlimited talk, text, and data, as well as the option to add on high-speed data. On its page promoting the plans, AT&T does have a disclaimer for each plan that the company "may slow speeds."
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Adorable Tots has one of the largest displays of nursery goods and furniture in the UK and are based in Rochdale, Greater Manchester. The showroom on Well l' Th' Ln, Rochdale has over 30 nursery furniture sets on display and a vast range of pushchairs, car seats, accessories and interiors from all the leading brands including Bugaboo, iCandy, Cybex, Uppababy, Besafe, Maxi Cosi, Kidsmill, Boori and many more.
Platting Lane Rochdale, Based in an Old Mill with over 15,000sqft of space which Adorable Tots owners Conrad and Victoria have sensitively renovated to create an amazing showroom, filled with prams, furniture, car seats, baby bedding and much more. Minutes away from the M62 Junction 20 exit, its discreet location and free private parking facilities make it a perfect environment for you to browse with ease and enjoy a personalised service from our team.


text:
LGBT Romance Deals Friday, August 4th
August 4, 2017 ~ Chris McHart
Owned by Tanya Chris
Liam should never have sassed his best friend Kurt's father that way, not when he knows how discipline is handled in the Santino household. Now Liam's got two problems: Mr. Santino's belt and Kurt's bare hand. Or rather, he's got one problem: the fact that all this old-fashioned discipline is making him hornier than hell.
Kurt's determined to make Liam stop perving on his dad. Liam just needs one more punishment. Can the two college students work out an arrangement that satisfies all their desires?
This short story (approximately 15,000 words) features lots of spankings with various implements and a HEA ending.
As Big As The Sky by Amy Aislin
Sam wants nothing to do with his irresponsible, sarcastic neighbor… Or does he?
Sam McAuley is having a rough start to the summer: Not only is he being sued, but the new guy running the animal rehabilitation center next door has no idea what he's doing and his runaway chickens constantly end up in Sam's pristine yard.
Everything is temporary for Bo Novak. For as long as he can remember, it's been one town to the next, one school to the next, one job to the next. Even his current job—running his sister's animal rehab center while she's away on a four-month leave—is temporary. And he does know what he's doing, thank you very much. Sure, things don't always run smoothly, but the stick-in-the-mud next door could be a little nicer about it.
One overheard conversation, an olive branch, and a baseball game might show these guys that being at odds isn't really what they want, and that what they want might just be each other.
Gabriel by RJ Scott
Trapped in darkness, can an escort find a man to help him into the light?
Gabriel Reyes never gave in. He fought and was hurt, was abused but escaped with his life. He made his way in the world using the one thing he was good at: sex. He earned a place with a man who controls everything but Gabriel is safe; he's made it.
Cameron Stafford hires Gabriel for a night, needing nothing more than a pretend boyfriend to get his dysfunctional family off his back. With the money he has in the bank and his own hotel, why won't they just leave him alone? It doesn't matter that a degenerative disease has stolen his vision, or that his last boyfriend was a bastard who tried to steal from him; for now he has purpose.
When Gabriel and Cam fall for each other, can they find real happiness and, maybe, a forever that will save them both?
A new story set in the world of Jack and Riley Campbell-Hayes and the Double D Ranch, Texas.
Please be aware: emotional and physical abuse are depicted on the page in this book
My Demon, My Vampire by Michael Mandrake
Sign up for Sharita's Newsletter and receive a FREE copy of the book!!
Instafreebie
I am obsessed with my pupil. Despite being in love with another immortal, I will continue to pursue the vampire who should be rightfully mine.
Small Steps by Chris McHart
*** Rainbow Awards Honorable Mention***
Ben Amann currently hates everything: The accident that temporarily put him in a wheelchair, the fact that he has to go for rehab and live in an assisted living home as well. Sebastian Hofers, the good looking but equally bad-tempered new assistant to his rehab therapist changes that.
Sebastian has two choices after causing an accident while driving drunk: community service hours or go to jail. The decision is a no-brainer, and so he meets Ben at the rehab center. The two of them hit it off and slowly, Sebastian sees more than just a patient in Ben.
But their growing relationship faces hard trials, not only because of Sebastian's heavy drinking, but also because of the truth: The two of them already met on an icy street, eight months ago.
Can love and forgiveness overcome the overwhelming guilt and resentment?
Contains: Two ill-tempered men, a lot of hang-ups, a shared hope, and a destroyed dream.
Trigger Warning: deals with alcohol abuse and alcoholism
Win a Kindle Fire!
‹ PreviousLGBT Romance Deals Tuesday, August 1st
Next ›LGBT Romance Deals Friday, August 11th


text:
Home Football News Troy Deeney: Watford legend joins boyhood club Birmingham
Troy Deeney: Watford legend joins boyhood club Birmingham
Birmingham has announced the signing of Troy Deeney on a two-year deal from Watford. The striker spent more than a decade at Watford, making more than 400 appearances for the club. Deeney had a year left on his contract but Watford allowed him to leave as a free agent. Birmingham is his hometown team and has agreed to join the club until 2023 with a further option of a year. Deeney joined Watford from Walsall in 2010 and scored 140 goals for the club in 419 appearances.
It's weird being asked to express my feelings on my life at Watford Football Club and the emotions I feel about leaving a club so important to me." Watford legend Troy Deeney said. "I feel sadness and loss, almost like a close family member has just died. I feel excited about my new journey and the rest of my life. Most of all I feel tremendous pride for what I've achieved and the friendships and connections I've made. Watford literally has changed my life."
"The Watford family redeemed me and helped get me back on track when I was at my lowest ebb," he added. "Watford is a small part of planet earth but for some of the most turbulent years of my life it was the centre of my universe and I couldn't have wished for better supporters holding me up and I have been truly honoured to be the captain of that club and the fans' representative on the pitch."
Also, Read Sergio Aguero: Barcelona register forward after pay cuts
Previous articleSergio Aguero: Barcelona register forward after pay cuts
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text:
John Earman
John Earman is Distinguished University Professor Emeritus of History and Philosophy of Science at the University of Pittsburgh. He is the author of World Enough and Space-Time: Absolute vs. Relationship Theories of Space and Time and Bayes or Bust? A Critical Examination of Bayesian Confirmation Theory .
John Earman is Distinguished University Professor Emeritus of History and Philosophy of Science at the University of Pittsburgh. He is the author of World Enough and Space-Time: Absolute vs. Relationship Theories of Space and Time and Bayes or Bust? A Critical Examination of Bayesian Confirmation Theory . See less
John Earman book subjects
Science > Philosophy & Social Aspects
Science > Relativity
Science > History
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Tytus Howard had a few rough moments during the first day of Senior Bowl practices, but the Alabama State offensive lineman was considered among the most intriguing draft prospects.
Howard, who measured at 6-foot-5, 322 pounds and 34½-inch arms, got rave reviews from NFL Draft analysts in Mobile, Alabama.
What observers like about Howard, and what was on display during workouts, is his size, lateral movement and ability to play multiple positions along the offensive line.
At the Senior Bowl South Team practice. I've been impressed with Alabama State OT Tytus Howard thus far. 6-6, 311 pounds. Showing good athleticism. Can play guard too.
Below is Howard impressively continuing to block an edge rusher despite his helmet coming off.


Titan ICT is a trusted partner when it comes to professional advice and strategic guidance for Fibre-to-the-Curb/Home/Business (FTTx) networks in Australia.
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FTTx networks can support traditional or multimedia communications, very high-speed data and internet services, broadcast and interactive television, video-on-demand, and many more applications because it has limitless capacity.
Working closely with clients in choosing the right solution to meet their requirements, our aim is to present a design that provides a complete broadband solution and effectively delivers the path for realisation of the best technology possible.
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For more information on Access Technology contact us or download the Access Technologies brochure.


text:
From 1965 – 2065: The Evolution of Anti-Racial Discrimination Law
School of Law event Thursday 3 December 2015
Date: Thursday 3 December 2015, 6:45 – 8:00
Location: Liberty Building SR (1.11)
December 2015 marks fifty years since the first anti-racial discrimination law was passed in the UK.
Come to a free evening lecture and hear about how anti-racial discrimination legislation has changed society in the UK and abroad.
Click on the link below and complete the registration form to confirm your place.
Registration form for 'From 1965 – 2065: The Evolution of Anti-Racial Discrimination Law'
Join Dr Iyiola Solanke, senior lecturer at Leeds School of Law, as she asks how the 1965 Race Relations Act came into being, and how it has changed law and society in the UK and abroad. Dr Solanke will consider whether it has achieved as much as possible, given the structural limitations inherent in its design, and consider how legal protection from racial discrimination will look in 2065.
The lecture will last for approximately 45 minutes, with time for questions afterwards.
See all School of Law events
Environmental Liabilities and Insolvent Polluters in China
School of Law - Wednesday 20 January 2021
Regulating Digital Currencies: Central Bank-Sponsored and Stablecoins
School of Law - Wednesday 10 February 2021
'Macromedical' Regulation


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Since February 2018 LIS is part of Sanne Group plc. SANNE is a leading global provider of alternative asset and corporate services with more than 1,400 people in 18 offices spread across the Americas, EMEA, Asia-Pacific and Mauritius. SANNE is a FTSE 250 listed business on the London Stock Exchange.


text:
@interface XAAspectKeywordTestClass : NSObject
@end
@implementation XAAspectKeywordTestClass
@end

#undef NSAssertMacroKeywordEqual
#define NSAssertMacroKeywordEqual(Keyword1, Keyword2, message, ...) // Don't make the assertion work in this test file.

// -----------------------------------------------------------------------------
// Change `_isDefinedAtAspectDetected` to `YES` if `AtAspect` is defined.
#undef AtAspect
#define AtAspect AnyThing // Defined

BOOL _isDefinedAtAspectDetected = NO;
#undef _XAAspectNamespaceCheckerDefault
#define _XAAspectNamespaceCheckerDefault (_isDefinedAtAspectDetected = YES)

#define AtAspectOfClass XAAspectKeywordTestClass
@classPatchField(XAAspectKeywordTestClass)
@end
// -----------------------------------------------------------------------------
// Change `isBlankAtAspectDetected` to `YES` if a 'blank' error is detected.
#undef AtAspect
#define AtAspect // Blank

BOOL _isBlankAtAspectDetected = NO;
#undef _XAAspectNamespaceChecker_aspect_
#define _XAAspectNamespaceChecker_aspect_ metamacro_evaluate_push(_isBlankAtAspectDetected = YES)

#undef AtAspectOfClass
#define AtAspectOfClass XAAspectKeywordTestClass
@classPatchField(XAAspectKeywordTestClass)
@end
#undef AtAspectOfClass
// -----------------------------------------------------------------------------
// Change `_isUndefinedAtAspectDetected` to `YES` if an 'undefined' error is detected.
#undef AtAspect // Undefined

BOOL _isUndefinedAtAspectDetected = NO;
#undef _XAAspectNamespaceChecker_aspect_AtAspect
#define _XAAspectNamespaceChecker_aspect_AtAspect metamacro_evaluate_push(_isUndefinedAtAspectDetected = YES)

#undef AtAspectOfClass
#define AtAspectOfClass XAAspectKeywordTestClass
@classPatchField(XAAspectKeywordTestClass)
@end
#undef AtAspectOfClass
// =============================================================================
// Change `_isDefinedAtAspectOfClassDetected` to `YES` if `AtAspectOfClass` is defined.
#undef AtAspect
#define AtAspect DetectAtAspectOfClassKeywordTest
#undef AtAspectOfClass
#undef _XAAspectOfClassNamespaceCheckerDefault
BOOL _isDefinedAtAspectOfClassDetected = NO;
#define _XAAspectOfClassNamespaceCheckerDefault (_isDefinedAtAspectOfClassDetected = YES)

#define AtAspectOfClass XAAspectKeywordTestClass // Defined
@classPatchField(XAAspectKeywordTestClass)
@end
// -----------------------------------------------------------------------------
// Change `_isBlankAtAspectOfClassDetected` to `YES` if a 'blank' error is detected.
#undef AtAspect
#define AtAspect UndefinedAtAspectOfClassKeywordTest

BOOL _isBlankAtAspectOfClassDetected = NO;
#undef _XAAspectOfClassNamespaceChecker_patch_
#define _XAAspectOfClassNamespaceChecker_patch_ metamacro_evaluate_push(_isBlankAtAspectOfClassDetected = YES)

#undef AtAspectOfClass
#define AtAspectOfClass // Blank
@classPatchField(XAAspectKeywordTestClass)
@end
// -----------------------------------------------------------------------------
// Change `_isUndefinedAtAspectOfClassDetected` to `YES` if an 'undefined' error is detected.
#undef AtAspect
#define AtAspect BlankAtAspectOfClassKeywordTest

BOOL _isUndefinedAtAspectOfClassDetected = NO;
#undef _XAAspectOfClassNamespaceChecker_patch_AtAspectOfClass
#define _XAAspectOfClassNamespaceChecker_patch_AtAspectOfClass metamacro_evaluate_push(_isUndefinedAtAspectOfClassDetected = YES)

#undef AtAspectOfClass // Undefined
@classPatchField(XAAspectKeywordTestClass)
@end
// -----------------------------------------------------------------------------

// =============================================================================
#pragma mark - Test Case
// =============================================================================

@interface UserDefinedMacroKeywordTest : XCTestCase

@end

@implementation UserDefinedMacroKeywordTest

- (void)setUp {
  [super setUp];
  // Put setup code here. This method is called before the invocation of each test method in the class.
}

- (void)tearDown {
  // Put teardown code here. This method is called after the invocation of each test method in the class.
  [super tearDown];
}

- (void)testIsDefinedAtAspectDetected {
  XCTAssert(_isDefinedAtAspectDetected,
            "The `@classPatchField()` should detect the defined `AtAspect`.");
}

- (void)testIsBlankAtAspectDetected {
  XCTAssert(_isBlankAtAspectDetected,
            "The `@classPatchField()` should detect the blank `AtAspect`.");
}

- (void)testIsUndefinedAtAspectDetected {
  XCTAssert(_isUndefinedAtAspectDetected,
            "The `@classPatchField()` should detect the undefined `AtAspect`.");
}

- (void)testIsDefinedAtAspectOfClassDetected {
  XCTAssert(_isDefinedAtAspectOfClassDetected,
            "The `@classPatchField()` should detect the defined `AtAspectOfClass`.");
}

- (void)testIsBlankAtAspectOfClassDetected {
  XCTAssert(_isBlankAtAspectOfClassDetected,
            "The `@classPatchField()` should detect the blank `AtAspectOfClass`.");
}

- (void)testIsUndefinedAtAspectOfClassDetected {
  XCTAssert(_isUndefinedAtAspectOfClassDetected,
            "The `@classPatchField()` should detect the undefined `AtAspectOfClass`.");
}

@end


No sound technician should leave home without a cable tester. This handy device allows you to test your audio cables in a flash for things like cable breakage, loose contacts, and short circuits. LED lamps on the housing provide a clear status indication and often, the tester offers a wide variety of plugs so you can check your XLR, mini jack, jack, and RCA cables. If you don't want to discover one of your cables is faulty right before going on stage, these testers are a smart investment! Check out our audio testers & meters as well, which include the decibel meter.
Devine's CABT100 is a cable tester with eleven different connectors on board allowing you to test a wide range of cables. The connectors include XLR, MIDI, RJ45, S-video, USB-B, DIN, mini jack, RCA and jack as well as speakON.
The CT 100 cable tester quickly and easily checks all your cables. It accepts almost every type of connectors: XLR, mono and TRS phone (1/4 inch, 1/8 inch, TT), RCA and MIDI.
This tool is essential for your toolbox! With this cable tester you can easily test six different cables with six different plugs one by one.
With a complete all-in-one cable tester, you'll never have to deal with faulty cables again! The Behringer CT200 allows you to test virtually any cable type in three different ways.
DBX's CT-3 advanced cable tester lets you check a variety of cables with ease. The tester can even be divided into two parts, a transmitter and a receiver, so that pre-installed and long cables can be tested too.
The CT-2 is a compact and shockproof cable tester by DBX. If you're a sound engineer, this invaluable device should be part of your toolbox.
With the Mackie MTEST-1, you'll know right away whether your cable is functioning properly or not. It's suitable for jack, XLR, RCA, Speakon, MIDI and Banana connectors as well as adapter cables with different connectors.
A speaker tester is a handy device for checking how well your speakers are functioning. This Fischer Amps tester is suitable for both active and passive speakers.
Are you suffering from problems with your line or microphone inputs? This A15TG tone generator was designed to track these with a 700Hz tone, so that you can then solve the problem.
Truetone's 1 SPOT mA Meter is a simple device that allows you to measure how much power effects pedals use. It also has a built-in cable tester making it a handy tool for all musicians.


Flowers on the Side is located in the heart of DeWitt, Iowa. We have six talented designers, with combined experience of over 75 years. Two of our designers are Iowa Master Florists and two more are studying for their masters.Whatever the occasion is we'll create the perfect arrangement (fresh or silk), wreath or gift basket for you. We can personalize each arrangement or basket to fit the person or special event.Our shop is very unique, carrying a wide variety of gift items, garden decor, crystal, decorative vases, pottery, Isabel Blooms, sculptures, and much more.We offer free delivery to the local hospital and funeral homes and have reasonable delivery charges for the surrounding areas.


text:
ISU 4U Promise>
CyMath
CyMath-Kids is a virtual mathematics program led by Dr. Namrata Vaswani from Iowa State University. The goal of CyMath is to inspire, motivate, and encourage students to see the joy, beauty, and wonder in mathematics as well as engage and challenge students in mathematics. Research has shown that students who have an increased interest in STEM in their early years of education are more likely to pursue that interest resulting in a STEM-related career (After-School Alliance Report, 1015). On the other hand, if enough encouragement and challenge is not provided in early grades, it can often lead to a loss of interest throughout the school years. CyMath offers extended help and challenge sessions for students to strengthen and deepen their mathematical understanding. Learn more >>
CyMath's Dr. Vaswani and Colleague Awarded NSF grant
ISU 4U Promise Book Study
During the 2019-2020 school year, the ISU 4U Promise hosted a book study with six King and Moulton teachers over The Guide for White Women Who Teach Black Boys. The group met monthly to discuss each of the six sections of the book with topics such as: "Exploring the Self" and "Understanding the Constraints and Challenging the Narratives About Who Black Boys Are and Who White Women Can Be." This fall, there was enthusiasm to continue the conversation with a new book: Stamped: Racism, Antiracism, and You by Jason Reynolds and Dr. Ibram X Kendi. This time, the group expanded to include interested Elementary Education majors from the School of Education at Iowa State. In all, seven teachers and five El Ed majors participated in this book study that met on Zoom three times during fall semester. Learn more >>
ISU 4U Promise Volunteer Program
The ISU 4U Promise volunteer program recruits, trains, and places ISU students in King and Moulton classrooms. Volunteers help classroom teachers by reading with students, helping them with assignments, and talking about college. The goal of the program is to provide role models for college-going and promote an ISU 4U Promise Scholar identity at a young age.
ISU College Partnerships
In an effort to teach King and Moulton students more about the breadth of careers available to them at ISU, grade levels at each school have been paired with an undergraduate college at ISU. Our goal is to connect resources from each college, such as fun, career exploration activities, with its partnered grade level. The pairings are:
Kindergarten/College of Agriculture and Life Sciences
First Grade/College of Design
Second Grade/College of Business
Third Grade/College of Human Sciences
Fourth Grade/College of Liberal Arts and Sciences
Fifth Grade/College of Engineering
This annual event promotes college-going at Iowa State University for students at King and Moulton, as well as for older sixth through 12th grade ISU 4U Promise-eligible students and their families. ISU student organizations and academic units showcase their work through age-appropriate activities.
Middle and High School Outreach
ISU 4U Promise/DMPS Communication Hub
All 6th-12th grade DMPS students who are eligible for and officially enrolled in the ISU 4U Promise are connected to a communication hub through Microsoft Teams. This Team offers a space to share information about upcoming ISU opportunities, as well as a way for students to communicate directly with the ISU 4U Promise office.
11th-12th Grade Outreach
Beginning in 11th grade and continuing through 12th, the ISU Offices of Admissions and Student Financial Aid, in collaboration with the ISU 4U Promise office, will be reaching out to ISU 4U Promise students with information about the admissions process, financial aid, and filling out the FAFSA.
College-Going Curriculum
In 2017 a small curriculum was developed for teachers at King and Moulton to support their efforts to talk about college in the elementary classroom. Lessons in this curriculum explore college basics, and an activity at each grade level explores careers related to a particular ISU college.
King and Moulton Teacher Liaison Teams
Teachers at King and Moulton provide vital input and feedback about the progress of the ISU 4U Promise initiative. Through regular meetings with the ISU 4U Promise Program Coordinator, these teachers take the lead on promoting college-going and the ISU 4U Promise in a variety of ways throughout their schools.
The Community Alliance provides a structure for Iowa State Extension and Outreach, community organizations, agencies, and businesses to participate in the ISU 4U Promise. Given that the long-term objective of the ISU 4U Promise is to maintain a college-going pathway for youth attending King and Moulton elementary schools, the Community Alliance aims to align with support systems for in- and out-of-school education. We believe the community organizations that service the youth and families of these two schools are in integral aspect of the success of the ISU 4U Promise. Learn more >>
Practica Supports
Each semester, pre-service teachers in the School of Education (CHS) have the opportunity to be considered for a practicum placement in classrooms at King or Moulton Elementary. ISU students placed in these schools are given additional supports including an introductory orientation before setting foot in the classroom, a video series based on Diversity Pedagogy, an online Discussion Board where they write reflections and self-reflections (on topics such as Ethnic Identity Development, Implicit Bias, Culturally Inclusive Classrooms, etc.), and feedback sessions with cooperating teachers and the ISU 4U Promise Program Specialist at the end.
Teacher Education Students
Elementary education majors at ISU have the opportunity to do their field experiences at King or Moulton elementary schools. Currently, this opportunity includes additional resources for pre-service teachers to learn about urban education, such as an overview of the communities, neighborhood walks, debriefing conversations and work in community organizations.
ISU's Research Institute for Studies in Education (RISE) is the evaluator for the ISU 4U Promise. RISE's goal is to document and describe the impact and implementation context of the ISU 4U Promise.
ISU 4U Promise
1218 Lagomarcino Hall
901 Stange Road
isu4u@iastate.edu
Key Initiatives and Strategic Plan
Centers, Institutes, and Facilities
College of Human Sciences social media directory
About the Partnership
Announcements and Celebrations
College Partnerships
CyMath Kids
Mini Conference
Scholarly Efforts
News/Archive


text:
Q: xslt tokenize() and "Not a node item" error I use tokenize() function to iterate through set of values, but then I try to use this values in template calls - "Not a node item" error occurs.
        <xsl:for-each select="tokenize($edge_pairs,';')">
                <xsl:if test="number(string-length(.)) > 0">
                    <xsl:variable name="c_row" select="." as="xs:string"/>
                    <xsl:variable name="src" select="substring-before($c_row,':')" as="xs:string"/>
                    <xsl:variable name="dst" select="substring-after($c_row,':')" as="xs:string"/>
                        <xsl:call-template name="links">
                            <xsl:with-param name="src1" select="$src"/>
                            <xsl:with-param name="dst1" select="$dst"/>
                        </xsl:call-template>
                </xsl:if>
            </xsl:for-each>

this is raw that triggers error:
<xsl:for-each select="root()//gml:edge[@source = $src1 and @target = $dst1 or  @source = $dst1 and @target = $src1]">

A: Assuming the code that triggers the error is in the named template links, then the issue is you are no longer in the context of the source XML document. You are inside an xsl:for-each on a tokenised string, so the context is an atomic value (i.e. a single string).
<xsl:for-each select="tokenize(a,';')">

This means the root() function will not work because the context is a string, and not a node in a document object.
The solution is define a global variable (i.e. a child of xsl:stylesheet, outside of any templates), that references the root:
<xsl:variable name="root" select="root()" />

Then you can change your xsl:for-each that is failing to this:
<xsl:for-each select="$root//gml:edge[(@source = $src1 and @target = $dst1) or (@source = $dst1 and @target = $src1)]">

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text:
Q: Is there a way to watch file changes in main js file runned in nodejs? There is a main.js javascript file with programm.
I run it:

node --inspect-brk index.js

Every time when I change something in this file I have to rerun it.
I need some way to let nodejs know that this main.js file was changed and make nodejs rerun it.
Is there a way to watch file changes in main js file runned in nodejs?

A: You can use nodemon. It will detect any changes to your directory and rerun the app.
npm install --save-dev nodemon
nodemon --inspect-brk index.js


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